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Sample records for asylum lake mi

  1. Seasonal variations in pore water and sediment geochemistry of littoral lake sediments (Asylum Lake, MI, USA

    Directory of Open Access Journals (Sweden)

    Miller Douglas

    2006-12-01

    Full Text Available Abstract Background Seasonal changes in pore water and sediment redox geochemistry have been observed in many near-surface sediments. Such changes have the potential to strongly influence trace metal distribution and thus create seasonal fluctuations in metal mobility and bioavailability. Results Seasonal trends in pore water and sediment geochemistry are assessed in the upper 50 cm of littoral kettle lake sediments. Pore waters are always redox stratified, with the least compressed redox stratification observed during fall and the most compressed redox stratification observed during summer. A 2-step sequential sediment extraction yields much more Fe in the first step, targeted at amorphous Fe(III (hydroxides (AEF, then in the second step, which targets Fe(II monosulfides. Fe extracted in the second step is relatively invariant with depth or season. In contrast, AEF decreases with sediment depth, and is seasonally variable, in agreement with changes in redox stratification inferred from pore water profiles. A 5-step Tessier extraction scheme was used to assess metal association with operationally-defined exchangeable, carbonate, iron and manganese oxide (FMO, organic/sulfide and microwave-digestible residual fractions in cores collected during winter and spring. Distribution of metals in these two seasons is similar. Co, As, Cd, and U concentrations approach detection limits. Fe, Cu and Pb are mostly associated with the organics/sulfides fraction. Cr and Zn are mostly associated with FMO. Mn is primarily associated with carbonates, and Co is nearly equally distributed between the FMO and organics/sulfide fractions. Conclusion This study clearly demonstrates that near-surface lake sediment pore water redox stratification and associated solid phase geochemistry vary significantly with season. This has important ramifications for seasonal changes in the bioavailability and mobility of trace elements. Without rate measurements, it is not possible to

  2. 78 FR 72706 - Notice of Inventory Completion: Michigan State Police, Houghton Lake Post, Houghton Lake, MI

    Science.gov (United States)

    2013-12-03

    ... National Park Service Notice of Inventory Completion: Michigan State Police, Houghton Lake Post, Houghton Lake, MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Michigan State Police, Houghton Lake Post has completed an inventory of human remains, in consultation with the appropriate...

  3. 78 FR 21260 - Safety Zone; Lubbers Cup Regatta; Spring Lake, MI

    Science.gov (United States)

    2013-04-10

    .... SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice... SECURITY Coast Guard 33 CFR PART 165 RIN 1625-AA00 Safety Zone; Lubbers Cup Regatta; Spring Lake, MI AGENCY... safety zone on Spring Lake in Spring Lake, Michigan. This safety zone is intended to restrict...

  4. 75 FR 35294 - Safety Zone; Marquette 4th of July Fireworks, Marquette Harbor, Lake Superior, Marquette, MI

    Science.gov (United States)

    2010-06-22

    ... Harbor, Lake Superior, Marquette, MI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on Marquette Harbor, Lake Superior, Marquette, MI...: If you have questions on this temporary rule, call or e-mail BMC Gregory Ford, Marine...

  5. 76 FR 22064 - Safety Zone; Michigan Bankers Association Fireworks, Lake Huron, Mackinac Island, MI

    Science.gov (United States)

    2011-04-20

    ... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting, but you may..., Lake Huron, Mackinac Island, MI AGENCY: Coast Guard, DHS. ACTION: Notice of proposed rulemaking...: If you have questions on this proposed rule, call or e-mail BMC Gregory Ford, Prevention...

  6. 75 FR 38721 - Safety Zone; Munising 4th of July Fireworks, South Bay, Lake Superior, Munising, MI

    Science.gov (United States)

    2010-07-06

    ..., Lake Superior, Munising, MI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on South Bay, Lake Superior, Munising, Michigan. This zone... questions on this temporary rule, call or e-mail BMC Gregory Ford, Marine Event Coordinator, U.S....

  7. 75 FR 38723 - Safety Zone; St. Ignace 4th of July Fireworks, East Moran Bay, Lake Huron, St. Ignace, MI

    Science.gov (United States)

    2010-07-06

    ... Moran Bay, Lake Huron, St. Ignace, MI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on East Moran Bay, Lake Huron, St. Ignace... INFORMATION CONTACT: If you have questions on this temporary rule, call or e-mail BMC Gregory Ford,...

  8. 75 FR 34379 - Safety Zone; Mackinac Island 4th of July Fireworks, Lake Huron, Mackinac Island, MI

    Science.gov (United States)

    2010-06-17

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Mackinac Island 4th of July Fireworks, Lake Huron, Mackinac Island, MI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on Lake Huron, Mackinac Island, Michigan. This zone...

  9. Cultural Meromixis: the Influence of Road Salt Deicers on Two Urban Kettle Lakes

    Science.gov (United States)

    Koretsky, C.; Sibert, R.; Wyman, D. A.; Griffey, D.; Krishnamurthy, R. V.

    2014-12-01

    The increasing global use of road salt deicers has led to an influx of salts, particularly NaCl and CaCl2, into urban surface waters. This influx has led to documented salinization of drinking water supplies, as well as damage to ecosystems. There is an increasing recognition that the influx of road salt deciers may also influence the physical mixing of lakes, with dramatic consequences for lake biogeochemistry. In this study, the water column chemistry of two kettle lakes in urban Kalamazoo, MI, USA was monitored for over a year. Woods Lake, an ~9.7 ha, 14 m max depth lake, receives most water from storm water sewers, whereas nearby Asylum Lake, an ~19.8 ha, 15.8 m max depth lake, is primarily groundwater fed. The water columns of both lakes are strongly redox stratified, but exhibit some significant differences in water chemistry. The input of road salt has caused Woods Lake to transition to meromixis, with permanently anoxic bottom waters and significant accumulations of dissolved Mn(II), Fe(II), NH3, PO4-3 and sometimes HS- in the hypolimnion. In contrast, Asylum Lake appears to be monomictic, with turnover occurring in fall, but not spring. During most seasons, the hypolimnion of Asylum Lake has significant levels of dissolved Mn(II), NH3, PO4-3, and sometimes HS-, but dissolved Fe(II) remains below detection limits. A comparison of δ18O and δD with the local meteoric water line demonstrates that both lakes undergo significant evaporation. Woods Lake is considerably more influenced by evaporation than Asylum Lake, presumably due to the longer residence time of water in Woods Lake. The longer residence time, together with the smaller volume of water in Woods Lake, likely explains the more rapid transition to meromixis compared to Asylum Lake. This study demonstrates that road salt deicers can significantly influence the biogeochemistry and physical function of urban lakes, and in some cases can result in dimictic lakes transitioning to cultural meromixis.

  10. Daily Occupations among asylum seekers

    DEFF Research Database (Denmark)

    Morville, Anne-Le

    2014-01-01

    Asylum seekers often find themselves in a situation where the structure and content of daily occupations have been disrupted and they might have limited access to paid work and education. Studies have shown that asylum seekers experience occupational deprivation and a change in daily occupations...... which might even influence their identity. Such deprivation can eventually lead to dissatisfaction with everyday life and to occupational dysfunction, i.e. a decline in ADL ability. Asylum seekers are a group who are more likely to suffer from health problems than the background population. Especially...... torture survivors suffer from ill health. Pain and psychological symptoms are among the most frequent health issues for both asylum seekers and torture survivors and may cause occupation-related problems. The overarching aim of this thesis was to investigate how staying in an asylum centre influenced...

  11. Impact of asylum interviews on the mental health of traumatized asylum seekers

    OpenAIRE

    Katrin Schock; Rita Rosner; Christine Knaevelsrud

    2015-01-01

    Background: Asylum interviews within the asylum procedure are associated with psychological stress for traumatized asylum seekers. This study investigates the impact of asylum interviews on the mental health in a sample of 40 traumatized asylum seekers. The comparison group consisted of refugees (N=10) that had not been invited to an asylum interview. Additionally, the moderating effects of trial-related variables such as perceived justice of the trial, stress of giving testimony, and stress ...

  12. Length of stay in asylum centres and mental health in asylum seekers

    DEFF Research Database (Denmark)

    Hallas, Peter; Hansen, Anne R; Staehr, Mia A;

    2007-01-01

    BACKGROUND: The length of stay in asylum centres is generally mentioned as a possible health risk to asylum seekers. Medical staff working with asylum seekers has claimed that long lengths of stay in asylum centres might cause or aggravate mental disorders. We used records from a large, multiethnic...

  13. Refugee families during asylum seeking.

    Science.gov (United States)

    Sourander, Andre

    2003-01-01

    The mental health of refugee families with children during the asylum period is a neglected research area in psychiatry. The present paper describes the situation of 10 refugee families residing at an asylum centre in Finland. Case vignettes are presented to illustrate the situations of these families. The study shows a high rate of depressive and post-traumatic stress disorder-related symptoms among adult refugees. The case vignettes suggest that during the asylum period, many children and adult members of the family are not in a post-traumatic situation, but they live constantly in a distressing situation. The foremost distress amongst the asylum seekers appeared to be fear of deportation and separation from family members. Most of the adults and all children had not received any psychiatric or psychotherapeutic assessment or treatment. It is likely that current procedures for dealing with the asylum seekers contributes to the level of stress, family confusion and psychiatric problems in already traumatized refugee families. PMID:12775295

  14. Life in dispersal : narratives of asylum, identity and community

    OpenAIRE

    Brown, Philip

    2005-01-01

    This study explores how the immigration status of the 'asylum seeker' impacts upon notions of 'identity', 'community' and 'belonging' whilst claiming asylum in the UK. By taking a narrativedialogical approach this research explores the stories that have been constructed around 'asylum' by policy, those working with 'asylum seekers' and 'asylum seekers' themselves. This research looks at how the 'official' narratives of asylum are operationalised and delivered by workers contrac...

  15. Right to asylum and its protection

    OpenAIRE

    Kuosmanen, Jaakko Niilo

    2012-01-01

    The topic of this thesis is justice and asylum. The central argument in the thesis is that citizens of all states have a moral right that entitles them to asylum in certain circumstances of deprivation. The right to asylum can be understood as a general derivative right, and it is grounded in the more fundamental entitlement to basic needs. More specifically, I argue that all persons whose basic needs are insufficiently protected in their home states have the right to asylum when they cannot ...

  16. Mental health of failed asylum seekers as compared with pending and temporarily accepted asylum seekers

    OpenAIRE

    Mueller, J; Schmidt, M.; Staeheli, A; Maier, T.

    2011-01-01

    BACKGROUND: Asylum seekers (AS) and refugees often suffer from severe psychopathology in the form of post-traumatic stress disorder (PTSD). As PTSD impacts memory functions, and as asylum applications rely on personal accounts, AS with PTSD are at more risk of being rejected than refugees. METHODS: We studied the mental health of failed asylum seekers (FAS, N = 40) and a matched sample of AS (N = 40). Participants were administered structured interviews on sociodemographics, flight, exile and...

  17. Impact of asylum interviews on the mental health of traumatized asylum seekers

    Directory of Open Access Journals (Sweden)

    Katrin Schock

    2015-09-01

    Full Text Available Background: Asylum interviews within the asylum procedure are associated with psychological stress for traumatized asylum seekers. This study investigates the impact of asylum interviews on the mental health in a sample of 40 traumatized asylum seekers. The comparison group consisted of refugees (N=10 that had not been invited to an asylum interview. Additionally, the moderating effects of trial-related variables such as perceived justice of the trial, stress of giving testimony, and stress of waiting for the asylum interview were examined. Method: Participants were assessed on average 10 days before (t1 and 16 days after (t2 the asylum interview. Chi-square tests for dichotomous and categorical variables were used to compare the descriptive statistics of the two groups. To investigate symptom changes from t1 to t2, paired t-tests were calculated. The magnitude of effects was measured by Cohen's effect size d within groups. Hierarchical regression analyses were conducted for demographic and trial variables predicting posttraumatic intrusions, avoidance, and hyperarousal. Results: Data showed a significant increase in posttraumatic intrusions and a significant decrease in posttraumatic avoidance and hyperarousal symptoms from t1 to t2. No significant symptom changes in the posttraumatic stress disorder subscales were found in the comparison group. The results of hierarchical regression analyses revealed perceived justice of the interview to predict the increase of intrusions and the number of experienced traumata and testimony stress to predict posttraumatic avoidance. Conclusions: The present findings underline the stressful impact of asylum interviews on traumatized refugees. They indicate that the asylum interview might decrease posttraumatic avoidance and trigger posttraumatic intrusions, thus highlight the importance of ensuring that the already vulnerable group of traumatized refugees needs to be treated with empathy during their asylum

  18. Age assessment of young asylum seekers

    DEFF Research Database (Denmark)

    Hjern, Anders; Brendler-Lindqvist, Maria; Nørredam, Marie Louise

    2012-01-01

    During 2009, 15,100 unaccompanied children sought asylum in Europe. Many of them came from 'failed states' like Somalia and Afghanistan where official documents with exact birth dates are rarely issued. This has led to requests to health care professionals in many countries to assist migration....... CONCLUSION: To improve care for young asylum seekers with undetermined age, we suggest better legal procedures for the determination of age and a more flexible approach to chronological age....

  19. Asylum for persecuted homosexuals in the Republic of Korea

    Directory of Open Access Journals (Sweden)

    Andrew Wolman

    2013-04-01

    Full Text Available Two recent successful claims for asylum suggest that the Republic of Korea may be prepared to serve in the future as an important country of asylum for those suffering persecution due to their sexual orientation.

  20. EU asylum procedures and the right to an effective remedy

    OpenAIRE

    Reneman, Anne Marcelle

    2013-01-01

    Adequate and fair asylum procedures are a precondition for the effective exercise of rights granted to asylum applicants, in particular the right not be expelled to a country where they face the risk of being subjected to human rights violations. In 1999 the EU Member States decided to work towards a Common European Asylum System. In this context the Procedures Directive was adopted in 2005. This directive provides for important procedural guarantees for asylum applicants, but also leaves muc...

  1. European Asylum Law : and its Relation to International Law

    NARCIS (Netherlands)

    Battjes, H.

    2006-01-01

    In Chapter 1 I introduce the question of enquiry, the relation between Community and international law on asylum. Further, I sketch the content of the Refugee Convention, other relevant international law, the historical background of current Community asylum law (i.e. the asylum acquis from before 2

  2. Occupational deprivation in an asylum centre:

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Erlandsson, Lena-Karin

    2013-01-01

    This article presents a study of three asylum-seeking men from Iran and Afghanistan. It aimed to explore how and if they experienced occupations as occupations in a Danish asylum centre and how their life experience shaped their choice and value of current occupations. In-depth narrative interviews...... explored the participants’ occupational history and its influence on their occupations in the asylum centre. A thematic analysis showed that the participants had been subjected to occupational disruption and deprivation by politically oppressive systems even before their flight. Their occupations in...... Denmark were to a certain extent influenced by their earlier occupations and the current occupational deprivation they all experienced was due to limited possibilities in the centre. Although they tried their best to fill their days and create structure, there was a loss of valued occupations and a...

  3. Haitian Refugees Need Asylum: A Briefing Paper.

    Science.gov (United States)

    National Council of the Churches of Christ of the United States of America, New York, NY. Church World Service.

    Haitian refugees who are seeking political asylum in the United States are finding themselves unwelcome. Although various reports attest to continuing persecution in Haiti under the repressive Duvalier regime, the U.S. Immigration and Naturalization Service claims that the Haitians seek only greater economic opportunity and are not genuine…

  4. Bogus refugees? The determinants of asylum migration to Western Europe

    OpenAIRE

    Neumayer, Eric

    2005-01-01

    This article analyses the determinants of asylum migration to Western Europe. Potential asylum seekers balance the costs of staying versus the costs of migrating. Estimation results confirm that economic hardship and economic discrimination against ethnic minorities lead to higher flows of asylum seekers. However, political oppression, human rights abuse, violent conflict and state failure are also important determinants. Migration networks and geographical proximity are important facilitator...

  5. The externalisation of the asylum function in the European Union

    OpenAIRE

    Morgades Gil, S??lvia

    2010-01-01

    This paper aims to identify and assess the main items in the strategy followed by the EU and its member states on the externalisation of their asylum function. First, it analyses the European harmonisation of the return to safe third countries and to countries of first asylum, which is carried out by means of readmission agreements. Second, it refers to the strategies defined by the Hague and the Stockholm programs concerning the External Aspects of the European Union Asylum Policy, on the de...

  6. Lake

    Science.gov (United States)

    Wien, Carol Anne

    2008-01-01

    The lake is blue black and deep. It is a glaciated finger lake, clawed out of rock when ice retracted across Nova Scotia in a northerly direction during the last ice age. The lake is narrow, a little over a mile long, and deep, 90 to 190 feet in places according to local lore, off the charts in others. The author loves to swim there, with a sense…

  7. LGBTI asylum claims: the Central and Eastern European perspective

    Directory of Open Access Journals (Sweden)

    Krzysztof Śmiszek

    2013-04-01

    Full Text Available Recent research indicates that CEE countries still lag far behind therest of Europe in their asylum practices in relation to LGBTI asylumclaims. Low levels of awareness, lack of guidance and cultural hostility are jeopardising asylum seekers’ prospects for fair treatment.

  8. Outcomes among Asylum Seekers in Atlanta, Georgia, 2003--2012.

    Science.gov (United States)

    Evans, Dabney P; Donato, Caitlin E; Malewezi, Bridget A; Li, Anyie J; Corea, Mario J; Mitchell, Andrew B

    2015-10-01

    INTRODUCTION Asylum seekers face a wide array of challenges, including the need for a fair and just adjudication process. In the state of Georgia, the Atlanta Asylum Network addresses the needs of such individuals by providing them physical, psychological and gynecological assessments, the results of which are presented to the courts in the asylum appeal process. OBJECTIVE As a component of the Network's program evaluation, assess outcomes among asylum seekers using its services, as well as relation of outcomes to type of service provided, the individual's geographic origin and English language proficiency. METHODS A retrospective examination was conducted of program data gathered by the Network between 2003 and 2012. Subjects included asylum seekers who received assessments by the Network during this period. The primary variable of interest was the final case outcome, defined as determination of asylum status: granted, withholding of removal, administrative closure and prosecutorial discretion, denied or voluntary departure. Outcomes were subsequently collapsed into a single positive or negative outcome variable. Positive outcomes included asylum granted, removal withheld, administrative closure and prosecutorial discretion. Negative outcomes included asylum denied and voluntary departure. We conducted bivariate and multivariate analyses, relating final case outcomes to Network services, geographic origin and English language proficiency, among the key variables. RESULTS A total of 69 of 120 asylum seekers in the study had a known final case outcome, and of those, 63.8% (44) had a positive outcome; or 37% of the total number of asylum seekers (n = 120). Among the 20 who received 2 of the 3 types of assessment (physical, psychological, gynecological), 16 (80%) received a positive case outcome. Most persons with a known final outcome came from Africa (41), where 78% (32) of cases resulted positive. Asylum seekers not proficient in English were 2.4 times more likely

  9. Problems Faced by Mexican Asylum Seekers in the United States

    Directory of Open Access Journals (Sweden)

    J. Anna Cabot

    2014-12-01

    Full Text Available Violence in Mexico rose sharply in response to President Felipe Calderón’s military campaign against drug cartels which began in late 2006. As a consequence, the number of Mexicans who have sought asylum in the United States has grown significantly. In 2013, Mexicans made up the second largest group of defensive asylum seekers (those in removal proceedings in the United States, behind only China (EOIR 2014b. Yet between 2008 and 2013, the grant rate for Mexican asylum seekers in immigration court fell from 23 percent to nine percent (EOIR 2013, 2014b. This paper examines—from the perspective of an attorney who represented Mexican asylum seekers on the US-Mexico border in El Paso, Texas—the reasons for low asylum approval rates for Mexicans despite high levels of violence in and flight from Mexico from 2008 to 2013. It details the obstacles faced by Mexican asylum seekers along the US-Mexico border, including placement in removal proceedings, detention, evidentiary issues, narrow legal standards, and (effectively judicial notice of country conditions in Mexico. The paper recommends that asylum seekers at the border be placed in affirmative proceedings (before immigration officials, making them eligible for bond. It also proposes increased oversight of immigration judges.

  10. The leprosy asylum in India: 1886-1947.

    Science.gov (United States)

    Robertson, Jo

    2009-10-01

    Writing against a historical practice that situates the leprosy asylum exclusively within prison-like institutions, this article seeks to show the variation in leprosy asylums, the contingencies of their evolution, and the complexity of their designs, by devoting attention to the characteristics of the leprosy asylum in India from 1886 to 1947, in particular to the model agricultural colony. Drawing upon the travel narratives of Wellesley Bailey, the founder of the Mission to Lepers in India, for three separate periods in 1886, 1890-91, and 1895-96, it argues that leprosy asylums were formed in response to a complex conjunction of impulses: missionary, medical, and political. At the center of these endeavors was the provision of shelter for persons with leprosy that accorded with principles of good stewardship and took the form of judicious use of donations provided by benefactors. As the Mission to Lepers began to bring about improvements and restructuring to asylums, pleasant surroundings, shady trees, sound accommodation, and good ventilation became desirable conditions that would confer physical and psychological benefits on those living there. At the same time, the architecture of the asylum responded to economic imperatives, in addition to religious and medical aspirations, and asylums moved towards the regeneration of a labor force. Leprosy-affected people were increasingly employed in occupations that contributed to their sustenance and self-sufficiency, symbolically reincorporating the body damaged by leprosy into the economic world of productive relations. PMID:19531547

  11. United States refugee and asylum policy: history and current approaches.

    Science.gov (United States)

    Stein, B N

    1986-01-01

    For most of the 4 decades since World War II, US refugee and asylum policy has been generous but ad hoc, discretionary, and highly variable favoring some refugee groups and discriminating against or ignoring others. This paper: 1) tries to clarify some of the terminology of the refugee field and explains the distinctions between asylum and resettlement, 2) provides some of the historical background that has brought the US to its present condition and chronicles the US overseas refugee admission policy, and 3) examines some asylum issues and other refugee issues. Asylum is far more difficult to control than refugee resettlement. As a result of what is perceived to be abuse of the asylum system, the US has joined the growing tendency of states to treat asylum-seekers as illegal migrants. The greatest problem with American asylum policy is its lack of fairness of application; many critics believe that foreign policy factors dominate asylum hearings rather than the individual merits of the case. The 3 classic solutions to this problem are resettlement, voluntary repatriation, and settlement in a country of 1st asylum. Only in the Indochinese refugee crisis has resettlement been widely used as a solution for 3rd World refugees. Nationalism and nation-building conflicts are at the root of many refugee movements; hosts are often no less nationalistic than source countries, thus many non-integrated refugees live in peril. Developed country political will and statesmanship are needed to revive resettlement as a durable solution. Resettlement may be difficult and costly, but the pluralistic western societies do offer an integrated new life. PMID:12178938

  12. Detention in Kenya: risks for refugees and asylum seekers

    Directory of Open Access Journals (Sweden)

    Lucy Kiama

    2013-09-01

    Full Text Available Refugees and asylum seekers detained in Kenya risk multiple convictions and protracted detention due to poor coordination between immigration officials, police and prison officers, coupled with lack of interpreters and low levels of knowledge among government officers.

  13. Usage of psychiatric emergency services by asylum seekers

    DEFF Research Database (Denmark)

    Reko, Amra; Bech, Per; Wohlert, Cathrine;

    2015-01-01

    given at the initial evaluation was ICD-10 F43.9 "reaction to severe stress, unspecified" (50%). Evaluations were made primarily by non-psychiatrists. No standardized screening or diagnostic instrument was used. CONCLUSION: This first description of the use of an acute psychiatric emergency service by......BACKGROUND: Asylum seekers are found to be at high risk of mental health problems. Little is known about the use of acute psychiatric emergency services by asylum seekers. AIM: To describe the usage of an inpatient/outpatient psychiatric emergency service in Denmark by adult asylum seekers, and...... predominantly male and married. The group consisted primarily (61%) of failed asylum seekers. Most patients (81%) presented with relevant mental health problems. The main reasons for presenting to the acute psychiatric emergency service were suicidal ideation and/or behaviour (60%). The most frequent diagnosis...

  14. Strategic asylum law making in Europe: institutional locus

    OpenAIRE

    Monheim, Jenny

    2007-01-01

    Given the background of changing institutional competencies in the European Union, we analyze the choice of asylum law standards of national and European parliaments, the Council of the European Union and codecision between the Council and the European Parliament. In a two country model we nd that the European arrangements maximize neither the welfare of the Member Countries nor the welfare of refugees. For the latter, there has been an improvement in the institutional location of asylum law ...

  15. Setting policy on asylum: Has the EU got it right?

    OpenAIRE

    Hatton, Tim

    2015-01-01

    Policy toward asylum-seekers has been controversial. Since the late 1990s, the EU has been developing a Common European Asylum System, but without clearly identifying the basis for cooperation. Providing a safe haven for refugees can be seen as a public good and this provides the rationale for policy coordination between governments. But where the volume of applications differs widely across countries, policy harmonization is not sufficient. Burden-sharing measures are needed as well, in orde...

  16. Mad Kings, Proper Houses, and an Asylum in Rural Ireland

    OpenAIRE

    Saris, A. Jamie

    1996-01-01

    WHAT IF THEY built an asylum and nobody showed up? By asking this question, I mean to forefront the problem of what sort of a structure it is to which people are committed or present themselves. In the extensive literature on asylums that has developed over the course of the last three decades, most authors assume a needy or dominated population to exist around such buildings who eventually give over their unfortunates to fill them up. Few theorists, moreover, look ser...

  17. Unaccompanied minor asylum seekers and participation in everyday life

    OpenAIRE

    Rajšter, Tina

    2011-01-01

    Unaccompanied minor asylum seekers receive little attention by the media and the general public, which is why I decided to look into and clarify their situation in Slovenia. In the theoretical part legal issues concerning refugee policy, the origin, numbers and vulnerability of asylum seekers in Slovenia and the rest of the world are explained. Furthermore the topic of participation is presented from different points of view. The second, empirical part of the thesis is aimed to find out ...

  18. Toward a Common Asylum Policy for the European Union

    OpenAIRE

    Toni Lluch

    2001-01-01

    In the process of harmonizing EU members states’ asylum policies, as a result of the lack of a common asylum policy, save for the limited Dublin Agreement, we are witnessing a wide variety of non-binding political declarations, at times more the product of fear than of considerations of human rights, that are setting the trend for countries’ actions. This article focuses on an analysis of the Dublin Agreement in terms of its achievements and failures over the years of its implementation.

  19. [Public Health initiative for improved vaccination for asylum seekers].

    Science.gov (United States)

    Brockmann, Stefan O; Wjst, Stephanie; Zelmer, Ursula; Carollo, Stefanie; Schmid, Mirjam; Roller, Gottfried; Eichner, Martin

    2016-05-01

    The number of asylum seekers in Germany has increased dramatically in 2015. Their medical care includes the officially recommended vaccinations; yet, no detailed information on this is yet available in Germany. In light of the rising number of asylum seekers, we have developed a concept to facilitate their vaccination. This concept includes the coordination of different partners, the supply of vaccines and other materials through the local health office, and the cooperation with the local physicians' association. To evaluate and accelerate progress, we compared the number of vaccinations conducted by physicians independently of the vaccination concept with those conducted within the new concept. For the period of investigation, 2,256 new asylum seekers were temporarily accommodated in the facilities. The vaccination concept was applied in only some of the facilities. Twenty-eight percent of all asylum seekers (642) were vaccinated at least once; 89 % of the vaccinees (571) were vaccinated within the newly developed concept. In the facilities that were not included in this concept, only 6 % of the refugees were vaccinated, whereas in the facilities that were included up to 58 % were vaccinated. Even though the new concept has started successfully, further innovations are required to reach sufficient vaccination coverage among asylum seekers. In view of the large number of new asylum seekers expected, the adjustment and expansion of the new concept requires professional planning and coordination. Furthermore, additional resources are required. PMID:27072499

  20. Haiti, insecurity, and the politics of asylum.

    Science.gov (United States)

    James, Erica Caple

    2011-09-01

    In this article, I seek to show how states of insecurity provoked by ongoing social, economic, and political ruptures in Haiti can disorder individual subjectivity and generate the flight of individuals seeking asylum within and across borders. Nongovernmental actors working in Haiti and with Haitians in the diaspora frequently managed the long-term psychosocial effects of insecurity. Their interventions can range from repressive to compassionate and influence the formation of identity and the embodied experiences of trauma for vulnerable Haitians. The case of a young Haitian refugee who was repatriated to Haiti from the United States in the 1990s demonstrates how insecurity is both an existential state reflecting the disordering of embodied experience, as well as a collective sociopolitical condition the effects of which cannot be managed or contained within national borders. The case is emblematic of the plight of thousands of Haitians affected by the January 12, 2010, earthquake. PMID:22007562

  1. Suffering and the struggle for recognition : lived experiences of the U.S. political asylum process

    OpenAIRE

    Haas, Bridget Marie

    2012-01-01

    This dissertation is an ethnographic study of seeking political asylum in the United States. With the implementation of restrictive immigration measures, particularly following September 11, 2001, seeking asylum in the U.S. has become increasingly onerous and protracted. From an institutional standpoint, the goal of the asylum process is to discern 'deserving' migrants ('authentic' refugees) from 'undeserving' migrants ('bogus' asylum seekers, economic migrants), and the process is undergirde...

  2. Refugeeship - A project of justification : Claiming asylum in England and Sweden

    OpenAIRE

    Magnusson, Nicola

    2011-01-01

    The aim of this thesis is to explore the asylum process from an experiential perspective, starting in the country of origin, fleeing, claiming asylum and being granted refugee status. The theoretical interest is to contribute with an understanding of how this asylum process impacts on personal meaning-making, focusing on identification and positioning work of the person forced to flee and make an asylum claim. With this purpose in mind, I have remained close to the experiences of the particip...

  3. 32 CFR 700.939 - Granting of asylum and temporary refuge.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Granting of asylum and temporary refuge. 700.939... Officer Present Contents § 700.939 Granting of asylum and temporary refuge. (a) If an official of the Department of the Navy is requested to provide asylum or temporary refuge, the following procedures...

  4. Neomodern insecurity in Haiti and the politics of asylum.

    Science.gov (United States)

    James, Erica Caple

    2009-03-01

    The term 'asylum' has a dual connotation that generates opposing but related forms of intervention: providing sanctuary and protection vs. imposing confinement and quarantine. The proliferation of "neomodern insecurity"--intrastate violence and the specter of transnational terrorism, arising within many postcolonial, postauthoritarian and postsocialist states--generates intervention practices that reflect the dual connotations of asylum. In fragile states like Haiti, national insecurity (ensekirite) often results in the flight of traumatized populations across and within national borders. For these individuals, 'asylum' connotes the attainment of political recognition and inclusion outside Haiti's space of ensekirite. Ironically, these vulnerable persons may be viewed as threats to the nations they seek to enter. In so-called secure states like the United States, the threat of insecurity often engenders interventions to contain, manage and rehabilitate states of disorder, as well as their disordered subjects. By chronicling the case of a young Haitian refugee who sought asylum in the United States, was detained and then repatriated after manifesting the disordered signs of insecurity, I argue that the Haitian trope of ensekirite captures and prefigures the subjective experience of neomodernity, one for which there is no asylum. PMID:19116780

  5. THE ASYLUM, BETWEEN HUMANITARIAN RESPONSE AND POLITICAL INSTRUMENT

    Directory of Open Access Journals (Sweden)

    Catrinel BRUMAR

    2012-06-01

    Full Text Available At 9 November 2010, the European Court of Justice, in a preliminary ruling, decided to depart from the interpretation promoted by the United Nations High Commissioner for Refugees, in the matter of the application of the exclusion clauses. The European Court considered that no proportionality test between human rights protection and gravity of a crime is to be applied in the case of a person suspected of having committed an act contrary to the principles and purposes of the United Nations. By eliminating this test, the Court is sending a signal on rethinking the asylum institution, from a humanitarian tool that it became, to a political instrument. This decision could not be read alone; corroborated to the concerns already raised on the suitable use of the asylum instrument to address massive humanitarian needs, it would indicate a reorientation in the interpretation of international norms governing the refugee law. Still, the human rights organs and the European Court of Human Rights continue to refer to the asylum as a situation where a humanitarian perspective, reflected in the proportionality test, or for those mechanisms the risk of human rights violation probability test, is still valid. The two apparently divergent directions will need to converge in the implementation of the European Union regulations on asylum. This paper is exploring the possible reinterpretation of the European norms, trying to identify the new trends in the political perspective of asylum and the limitations to these trends that the respect for human rights is establishing.

  6. [Asylum for curing or securing? The confinement of forensic patients as a challenge of asylum psychiatry in Imperial Germany].

    Science.gov (United States)

    Müller, Christian

    2006-01-01

    Asylum for curing or securing? The confinement of forensic patients as a challenge of asylum psychiatry in Imperial Germany. In Imperial Germany psychiatrists sought to give their asylums the character of modern medical hospitals. Due to the increase of insanity defence these efforts were obstructed by the high number of inmates with a criminal background. Special departments for mentally ill criminals were founded both in asylums and in prisons. But the clientele was not welcome in any of these institutions. Thus, there was a high fluctuation between prisons and asylums. A new definition of criminal responsibility was needed. In order to keep criminals out of their hospitals psychiatrists developed the medical concept of psychopathy referring to a mental defect without lack of responsibility. On the other hand penal law reformers plead to introduce preventive measures, such as security confinement, into the criminal law book. Since the resolution of the 'law against habitual criminals' in November 1933 judges are allowed to sentence mentally ill offenders to indefinite confinement in psychiatric institutions. PMID:17144371

  7. Psychological evaluation of asylum seekers as a therapeutic process.

    Science.gov (United States)

    Gangsei, David; Deutsch, Anna C

    2007-01-01

    Torture survivors are often reluctant to tell their stories. They typically make every effort to forget this painful, traumatic experience. Often they do not share with family, friends or healthcare professionals the fact that they have been beaten, raped or subjected to electrical shocks and other terrors. Talking means retrieving memories, triggering the feelings and emotions that accompanied the torture itself. Furthermore, refugee torture survivors feel that people won't understand or believe their experiences. However, survivors who escape their country may need to reveal their torture experience as they apply for asylum in the host country. When they prepare for the asylum process, it may well be the first time that they talk about the torture. Mental health professionals are often called upon to evaluate survivors and prepare affidavits for the asylum process, documenting the effects of torture. This creates a unique and priviliged opportunity to help survivors to address the devastating consequences of torture. Winning asylum is essential to recovery for a torture survivor in a country of refuge. Psychological evaluations of the consequences of torture can present information and evidence to asylum adjudicators which significantly increases understanding of the survivors' background and experiences as well as their manner of self-presentation in the courtroom or interview. They can empower the torture survivor to present his/her experiences more fully and confidently. Even apart from winning asylum, the process of the evaluation has many potential benefits for the survivor's emotional well-being. This includes helping the survivor understand the necessity of telling the story, illuminating the often poorly perceived link between current emotional suffering and past torture, facilitating the development of cognitive and emotional control, and healing the wounds of mistrust, humiliation, marginalization and fear. PMID:17728485

  8. Church Asylum - new strategies, alliances and modes of resistance

    DEFF Research Database (Denmark)

    Jørgensen, Martin Bak

    2013-01-01

    This article discusses the possibilities for democratic transformation in a landscape of political closure. Taking the case of Church Asylum [Kirkeasyl] as an example of new ways of resistance and participation in contemporary Denmark the articles argues that although the established political...... channels are characterised by closure alternatives may be formulated outside the parliamentarian system. Using contemporary perspectives on social critique and mobilization the article looks back at Church Asylum in 2009 and discuss the alliances, strategies and modes of resistance used during the event....... The article draws on a framework derived from political sociology and critical theory....

  9. Australian health policy on access to medical care for refugees and asylum seekers

    OpenAIRE

    Correa-Velez, Ignacio; Gifford, Sandra M; Bice, Sara J

    2005-01-01

    Since the tightening of Australian policy for protection visa applicants began in the 1990s, access to health care has been increasingly restricted to asylum seekers on a range of different visa types. This paper summarises those legislative changes and discusses their implications for health policy relating to refugees and asylum seekers in Australia. Of particular concern are asylum seekers on Bridging Visas with no work rights and no access to Medicare. The paper examines several key quest...

  10. Asylum Seekers in Europe: The Warm Glow of a Hot Potato

    OpenAIRE

    Giovanni Facchini; Oliver Lorz; Gerald Willmann

    2005-01-01

    The Common European Asylum System calls for increased coordination of the EU countries’ policies towards asylum seekers and refugees. In this paper, we provide a formal analysis of the effects of coordination, explicitly modelling the democratic process through which policy is determined. In a symmetric, two-country citizen-candidate setup, in which accepting asylum seekers in one country generates a cross-border externality in the other, we show that coordination is desirable. Internalizing ...

  11. Tradable Refugee-admission Quotas: a Policy Proposal to Reform the EU Asylum Policy

    OpenAIRE

    Hillel Rapoport; Jesús Fernández-Huertas Moraga

    2014-01-01

    he current EU Asylum policy is widely seen as ineffective and unfair. We propose an EU-wide market for tradable quotas on both refugees and asylum-seekers coupled with a matching mechanism linking countries' and migrants' preferences. We show that the proposed system can go a long way towards addressing the shortcomings of the existing system. We illustrate this claim using the recent problems regarding relocation faced by the European Asylum Support Office (EASO) in Malta.

  12. Experiences of asylum seeking women on housing and health care services in Bradford

    OpenAIRE

    Fuseini, Sulemana

    2009-01-01

    The purpose of this study was to look at housing and health care services provided for asylum seeking women in Bradford, and whether service delivery meets their needs and expectations. This study used a qualitative research approach; the method of data collection was focused group interviews. The participants were selected from the Bradford Ecumenical Asylum Concern (BEACON) project. 10 women seeking asylum were interviewed and the interview data was analysed through the method of conten...

  13. Gender Variation in Asylum Experiences in the UK: The Role of Patriarchy and Coping Strategies

    OpenAIRE

    Ruth L Healey

    2010-01-01

    Previous work suggests that female asylum seekers and refugees have more constraints on their actions than their male counterparts, as structural forces from the country of origin are reproduced in the host country. This paper explores the use of structuration theory in interpreting the impact of gender upon asylum seeker and refugee experiences in the UK. The experiences of, and coping strategies used by 8 male and 10 female asylum seekers and refugees from two different cities are analysed....

  14. A Study of Asylum Seeker/Refugee Advocacy: Paradoxes of Helping in a Climate of Hostility.

    OpenAIRE

    Wroe, Lauren

    2013-01-01

    This thesis is concerned with the extent to which hostility towards asylum seekers/refugees frames advocacy talk. Using a dialogical approach, I analyse how the identities of asylum claimants are dealt with by refugee advocates, in order to counter this hostility. My analysis is based on the collection of publicity materials from four refugee organisations, and from Narrative Biographical Interviews conducted with their staff, volunteers and asylum-seeking clients. Using the notion of dialogi...

  15. Narratives of Service Provision: A Dialogical Perspective on the ‘Support’ of Asylum Seekers

    OpenAIRE

    Brown, Philip

    2005-01-01

    This chapter focuses upon some of the narratives of housing and ‘support’ service provision set against the backdrop of the support of asylum seekers in the United Kingdom. Since 1999 specific asylum seeker support teams have been established within a number of local authorities throughout the UK contracted to the Home Office to provide housing and social support to destitute asylum seekers. Currently, the regions of the UK, operate within a national legislative arena led by...

  16. Asylum seekers and refugees in Indonesia: Problems and potentials

    Directory of Open Access Journals (Sweden)

    Muzafar Ali

    2016-07-01

    Full Text Available In the Indonesian West Java town of Cisarua, asylum seekers and refugees face prolonged periods of waiting in limbo. Australian government policies have contributed to the lengthy waiting times, particularly Operation Sovereign Borders. Those in protracted situations have found ways to ensure that during their time in Cisarua their basic needs are met and they demonstrate creativity and resilience in difficult circumstances. Education for children is a priority for asylum seeker and refugee communities and a learning centre developed by the community has provided hope for children and their families. The paper draws on the experiences of Author One during his waiting time in Cisarua and research conducted by Authors Two and Three in late 2013.

  17. [Asylum in Switzerland. Some aspects of refugee migration].

    Science.gov (United States)

    Bolzman, C; Musillo, I

    1987-06-01

    "Switzerland is the European country which, after Sweden, has received the highest number of refugees (30,000) in proportion to its population. Asylum seekers have increased considerably since 1979. They are coming mostly from Third World, politically unsettled countries. The essay presents the results of a survey conducted in Geneva on a sample of 549 asylum seekers assisted by public welfare agencies from 1974 to 1983. These refugees belong to the younger age bracket of the active population. About half of them have completed their secondary or tertiary education. But their professional, social and cultural adjustment poses some problems. The vast majority of them, in fact, are employed in unqualified occupations in the tertiary sectors." (SUMMARY IN ENG) PMID:12315256

  18. Impact of September 11 on refugees and those seeking asylum.

    Science.gov (United States)

    Piwowarczyk, Linda A; Keane, Terence M

    2007-12-01

    September 11, 2001 profoundly affected the American public. We share the views of a cohort of refugees and those seeking asylum from the Boston Center for Refugee Health and Human Rights. Of the 63 individuals from 18 countries interviewed, many had concerns about their personal safety following September 11, as well as fears related to deportation, arrest, detention, imprisonment, discrimination, physical violence and the destruction of property, and war. Asylum seekers were more likely than refugees to have concerns about their safety before their departure and during flight, as well as fear deportation and arrest after September 11. In the wake of September 11, most common coping strategies utilized included prayer (77.8%), speaking with friends from their own social group (47.6%), family (44.4%), and belief in fate (42.9%). PMID:18089639

  19. Asylum seekers and refugees in Indonesia: Problems and potentials

    OpenAIRE

    Ali, Muzafar; Briskman, Linda Ruth; Fiske, Lucy Imogen

    2016-01-01

     Asylum seekers and refugees in Indonesia increasingly experience protracted waiting times for permanent settlement in other countries. They have few, if any, legal rights, coupled with extremely limited financial resources and no access to government provided services. In response to the prospect of living for many years in this difficult and liminal space, a small community of refugees in the West Java town of Cisarua has built relationships, skills and confidence among themselves and with ...

  20. Credibility assessments as "normative leakage": asylum applications, gender and class

    OpenAIRE

    Hanna Wikström; Thomas Johansson

    2013-01-01

    Based on the assumption that credibility assessments function as 'normative leak­age' within the asylum process, we analyse how narratives of gender and class are articulated, rendered meaningful, or silenced in credibility assessments. Two cases concerning male applic­ants are selected in order to illustrate these processes. In relation to the existing concepts of internal/external credibility, we wish to introduce the concept of social credibility, which focuses on how the assessors read ...

  1. Gender-Based Persecution and the (inadequate) use of the Concept of Gender - A textual analysis of the construction of women's gender-based asylum claims in the Swedish asylum determination system

    OpenAIRE

    Johansson, Lovisa Viktoria Maria

    2013-01-01

    Abstract Asylum determination has, historically, not been sensitive to women's gender-based claims. Rather, male experiences and governmental persecution have been held as preferences in asylum determination. There have been international calls to assess gender-based claims in relation to a social constructivist approach towards gender, in order to eradicate the misinterpretations of women's asylum claims. This dissertation analyses the constructions of women's gender-based asylum claims...

  2. Asylum Doctor Extraordinaire: Dr. Thomas Drapes (1847-1919).

    Science.gov (United States)

    Kelly, B D

    2015-09-01

    Dr. Thomas Drapes (1847-1919) was resident medical superintendent of Enniscorthy District Asylum in County Wexford, Ireland from 1883 to 1919, and one of the leading figures in Irish asylum medicine for several decades. Drapes' career was as complex as it was remarkable. Drapes was elected president of the Medico-Psychological Association for the term 1911-12 but had to decline on health grounds. In 1912, however, he was unanimously elected as co-editor of the Journal of Mental Science, to which he devoted his considerable energies and intellect. Drapes published widely, opposing Emil Kraepelin's proposed division of "functional" psychosis into manic-depressive illness and dementia praecox; openly examining the use of "punitive measures" in asylums (Enniscorthy had notably low rates of restraint and seclusion); and publicly bemoaning the folly of "psychophysical parallelism", or the spurious division between mental and physical symptoms in medicine. Although not immune to passing trends in medical thought (e.g. regarding sterilisation of the mentally ill to prevent further mental disorder), Drapes was generally independent-minded, insightful and incisive, and his legacy was to help shape Irish mental health care for many decades. PMID:25833354

  3. An Overview of Pending Asylum and Refugee Legislation in the US Congress

    Directory of Open Access Journals (Sweden)

    Melanie Nezer

    2014-05-01

    Full Text Available There has been no significant legislation related to the asylum process enacted in Congress in nearly a decade.  In 1996, the Illegal Immigration Reform and Immigration Responsibility Act (IIRIRA became law, rolling back protections for asylum seekers by including a one-year deadline for filing asylum applications, subjecting asylum seekers to “expedited removal” procedures, and expanding the detention of asylum seekers. In 2005, Congress enacted the REAL ID Act, which created additional legal barriers to asylum, including new requirements for proving an asylum claim. During the past several sessions of Congress, bills have been introduced that would make significant changes to the country’s asylum laws and refugee admissions program. This paper provides an overview of the pending legislation and the changes proposed.  This overview is instructive in understanding (1 which members of Congress have demonstrated interest and leadership in refugee and asylum issues; (2 which refugee and asylum reform issues have been of most interest to members of Congress in recent years; (3 the different approaches to refugee and asylum issues by members of Congress who have shown leadership on these issues; and (4 which provisions have been enacted, which have gained traction, and which remain pending without significant movement through the legislative process.While it is difficult to imagine in the current partisan climate how any asylum or refugee legislation could be enacted into law, some legislative provisions have been reintroduced over a number of sessions of Congress and some have a history of bipartisan support.  Legislation focused on a group of particular interest or concern to members of Congress could gain traction.  A more comprehensive legislative approach framed by the need generally to improve the system could be less effective, particularly in the context of the years-long stalemate on comprehensive immigration reform

  4. Quality in Dutch asylum law : from ‘strict but fair’, to ‘fast but good’?

    NARCIS (Netherlands)

    Winter, Heinrich; Bolt, Korine

    2007-01-01

    The Aliens Act 2000 aimed to speed up and improve decision-making in asylum cases. To what extent were these objectives attained and what can be said on the basis of the available data about the factors which determine the quality of asylum decisions? Acceleration of the asylum procedure has certain

  5. 8 CFR 209.2 - Adjustment of status of alien granted asylum.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Adjustment of status of alien granted asylum. 209.2 Section 209.2 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS OF REFUGEES AND ALIENS GRANTED ASYLUM § 209.2 Adjustment of status of...

  6. 8 CFR 1209.2 - Adjustment of status of alien granted asylum.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Adjustment of status of alien granted asylum. 1209.2 Section 1209.2 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS ADJUSTMENT OF STATUS OF REFUGEES AND ALIENS GRANTED ASYLUM §...

  7. Occult Genres and the Certification of Madness in a 19th-Century Lunatic Asylum

    Science.gov (United States)

    Berkenkotter, Carol; Hanganu-Bresch, Cristina

    2011-01-01

    Using archival admissions records and case histories of patients at a British asylum from the 1860s to the 1870s, the authors examine the medical certification process leading to the asylum confinement of individuals judged to be "of unsound mind." These institutional texts are, the authors suggest, "occult genres" that function as complex acts of…

  8. Disciplinary power and the role of the subject at a nineteenth-century Danish asylum

    DEFF Research Database (Denmark)

    Hamre, Bjørn

    2010-01-01

    This article reports on the ways in which psychiatric practice and power were constituted in a Danish asylum at the beginning of the nineteenth century. The point of departure will be a complaint by a former patient questioning the practice at the asylum in 1829. In an analysis of this narrative...

  9. 77 FR 76352 - Adjustment of Status of Refugees and Aliens Granted Asylum

    Science.gov (United States)

    2012-12-28

    ... SECURITY 8 CFR Part 209 Adjustment of Status of Refugees and Aliens Granted Asylum CFR Correction In Title..., reinstate paragraphs (b) through (f) to read as follows: Sec. 209.2 Adjustment of status of alien granted asylum. * * * * * ] (b) Inadmissible alien. An applicant who is not admissible to the United States...

  10. Child Poverty as Public Policy: Direct Provision and Asylum Seeker Children in the Republic of Ireland

    Science.gov (United States)

    Fanning, Bryan; Veale, Angela

    2004-01-01

    This paper evaluates responses to asylum seeker children in Ireland from a child poverty perspective and from that of the United Nations Convention on the Rights of the Child. It draws upon research undertaken in early 2001 on behalf of the Irish Refugee Council among asylum seeker families with children in Cork, Limerick and Ennis on their…

  11. Family Support through Childcare Services: Meeting the Needs of Asylum-Seeking and Refugee Families

    Science.gov (United States)

    Dolan, Nicola; Sherlock, Catherine

    2010-01-01

    This article is a summary of the research carried out in relation to the experiences of asylum-seeking and refugee families regarding access and participation in local childcare services. Focus groups and interviews were carried out with 16 refugee and asylum-seeking parents, five childcare practitioners, and two support and development staff in a…

  12. Gender stereotyping in the Dutch asylum procedure: ‘independent’ men versus ‘dependent’ women

    NARCIS (Netherlands)

    P. Mascini; M. van Bochove

    2009-01-01

    Attention for discrimination against women in asylum law has grown considerably during the last few decades. Yet it is male claimants who have had smaller success Rates in the asylum procedures of different countries. Using administrative data from the Dutch INS, we show this difference is caused by

  13. Discursive Representations of Asylum Seekers and Illegal Immigrants in Ireland

    Directory of Open Access Journals (Sweden)

    Elaine Burroughs

    2013-12-01

    Full Text Available Migrants are often referred to as an all encompassing group of people and the “many faces of migration”, the variety of people, legalities and complexities involved, can be overlooked. The same can be said for non-EU migrants in the Irish context. Non-EU migrants (or those that are not Caucasian are generally viewed to be a distinct cohort of comparable migrants. Indeed, these migrants are often portrayed in a broadly negative way by key Irish institutions (such as the parliament or the media, and these representations impact upon how Irish society views non-EU migration and indeed migration in general. While Ireland is by no means the only European country in which this type of practice occurs, this paper aims to draw attention to generalized, inaccurate and misleading representations of non-EU migrants in Ireland, by specifically examining representations of asylum seekers and illegal immigrants. There can be an overlap in how these “types” of migrants are conceptualized and this paper therefore aims to develop an understanding of the implications involved for migrants categorized as an “asylum seeker” or an “illegal immigrant.” Furthermore, these topics are under-researched within the Irish context, yet they receive much political and public attention. At the same time however, this paper aims to challenge the labels assigned to non-EU migrants and the terminology that is used to define their identity so concretely. In the Irish context there is much confusion in relation to the multiple “faces” of non-EU migration, as a range of terminology is used to refer to them. This terminology is often used in an interchangeable manner, in an array of societal contexts. There is a consistent (whether this happens intentionally or unintentionally is debatable misuse of categories and migration terminology in Irish institutional discourses. Quite often those seeking asylum are referred to as illegal immigrants and vice versa

  14. Refugee and asylum law in a time of crisis

    OpenAIRE

    Hills, Hannah Ruth

    2016-01-01

    2015 saw the arrival of over one million asylum seekers in the EU, sparking what is now known as the European refugee crisis. The majority of those coming into the EU were doing so by boat from Turkey to Greece and then heading North, mainly to EU States such as Germany and Sweden. In order to deal with this so-called crisis, from September 2015 to March 2016 a number of EU and non-EU States along the Western Balkans route began to implement deterrence and prevention measures in order to redu...

  15. Activity of daily living performance amongst Danish asylum seekers

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Erlandsson, Lena-Karin; Eklund, Mona; Danneskiold-Samsøe, Bente; Christensen, Robin; Amris, Kirstine

    2014-01-01

    OBJECTIVE: The aim of this study was to evaluate the extent of Activities of Daily Living (ADL) ability impairment in newly arrived Danish asylum seekers. It was hypothesized that exposure to trauma and torture would negatively influence ADL performance and that measures of ADL ability would be...... and Process Skills (AMPS). Interviews were based on questionnaires about torture exposure, WHO-5 Wellbeing Index, Major Depression Inventory and Pain Detect Questionnaire. All participants were interviewed and tested using a linguistic interpreter. RESULTS: Thirty three (77%) participants reported...

  16. A longitudinal study of change in asylum seekers Activities of Daily Living ability while in asylum centre

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Amris, Kirstine; Eklund, Mona;

    2014-01-01

    questionnaire about exposure to torture and trauma. Ten months later, 17 participants were accessible for re-assessment, based on the same instruments as above. The participants took part in the usual activities in a centre during the time between baseline and follow-up. Results: At entrance, the asylum seekers...... impairment that increased during time spent in a centre, and that the increase may be associated with exposure to number of applied torture methods. Contribution to practice/evidence base of occupational therapy: The knowledge contributes to the planning and execution of preventive and rehabilitation...

  17. European Asylum Law and Policy: The EU and Slovak Perspectives The EU and Slovak Perspectives

    OpenAIRE

    Ferguson Sidorenko, O.

    2006-01-01

    textabstractThe right of asylum is rooted in the history of mankind (religious right of asylum (sanctuary)) and since the beginning of the modern State it has been rooted in the sovereignty of the State itself (the right of territorial asylum). The State retains the right to grant its protection to certain non-nationals or stateless persons, as a consequence of its territorial sovereignty, once the conditions laid down by the State have been complied with. In principle, it is the sovereign St...

  18. Asylum support for children and young people living in Kirklees: Stories of mothers

    OpenAIRE

    Smith, Kate; Lockwood, Kelly

    2015-01-01

    The report is based on a one-year pilot study by academic practitioners at WomenCentre, Kirklees, funded by the Nationwide Children’s Research Centre. This study has taken a localised approach to the Parliamentary Inquiry (2013) into asylum support for children and young people. We have placed the views of mothers of children who live or have lived in receipt of asylum support in Kirklees at the heart of the study. All of the mothers interviewed said that asylum support (accommodation and/or ...

  19. Asylum applications in the European Union: patterns and trends and the effects of policy measures.

    Science.gov (United States)

    Bocker, A; Havinga, T

    1998-09-01

    "Statistics on asylum applications have been used in a highly selective way in the debates on refugees and asylum policies in Western Europe, to justify restrictive measures. This paper provides a more systematic analysis of these statistics. It focuses on the pattern of origins and destinations for asylum seekers in the European Union in the period 1985-1994.... When the patterns of origin and destinations are compared for separate years, it becomes clear that the destinations of asylum movements have been constantly changing. Though some of the more remarkable shifts were clearly related to policy measures in the relevant countries, many measures produced only limited effects or failed to have any effect at all." PMID:12295700

  20. Ethical and professional considerations providing medical evaluation and care to refugee asylum seekers.

    Science.gov (United States)

    Asgary, Ramin; Smith, Clyde L

    2013-01-01

    A significant number of asylum seekers who largely survived torture live in the United States. Asylum seekers have complex social and medical problems with significant barriers to health care access. When evaluating and providing care for survivors, health providers face important challenges regarding medical ethics and professional codes. We review ethical concerns in regard to accountability, the patient-physician relationship, and moral responsibilities to offer health care irrespective of patient legal status; competing professional responsibility toward society and the judiciary system; concerns about the consistency of asylum seekers' claims; ethical concerns surrounding involving trainees and researching within the evaluation setting; and the implication of broader societal views towards rights and social justice. We discuss contributing factors, including inadequate and insufficient provider training, varying and inadequate institutional commitment, asylum seekers' significant medical and social problems, and the broader health and social system issues. We review existing resources to address these concerns and offer suggestions. PMID:23767428

  1. Moral architecture: the influence of the York Retreat on asylum design.

    Science.gov (United States)

    Edginton, B

    1997-06-01

    Institutional and architectural history places the asylum alongside the prison and other institutional types whose architectural characteristics emphasized confinement and control. This history obfuscates important differences in how ideas about treatment were represented in the particular design of these institutions; in other words, how the structure of a place became part of its discourse. What becomes obvious in nineteenth-century, asylum architecture is the influence of a small Yorkshire private asylum built by a Quaker, William Tuke, in 1796. The York Retreat, in form, solidified the ideas of 'moral treatment' in design and in turn assumed an exalted character in the design of late nineteenth-century asylums. Every researcher working in the field of the history of insanity acknowledges the importance of this event and its impact on the discourse of insanity for the century to follow. Few however talk about how its unique design was incorporated as part of this discourse. PMID:10671006

  2. [Beyond the asylum -An other view on the history of psychiatry in the modern age].

    Science.gov (United States)

    Fauvel, Aude

    2015-07-01

    If one thinks medicine, madness and the past, one image immediately pops into mind: that of the mental asylum. Following the famous work by Michel Foucault, Madness and Civilization: A History of Insanity in the Age of Reason, many historians have thus considered that the medicalization of insanity in the modern age had mostly led to a "great confinement" and a greater segregation of all individuals deemed mentally unfit during the "asylum era': However, new research demonstrates that this classic narrative of the psychiatric past needs to be revised. It discloses that, ever since the 191h century, a whole other medical culture existed as a challenge to asylums, a culture that advocated the integration of the mad and fought to disassociate psychiatry from the dominant model of confinement all throughout the occidental world. This article aims at presenting the results of these historical works that depict another aspect of the psychiatric history, exploring "boarding out" practices, instead of asylum ones. PMID:26111838

  3. [Psychopathology of asylum seekers in Europe, trauma and defensive functioning].

    Science.gov (United States)

    Mazur, V M-L; Chahraoui, K; Bissler, L

    2015-06-01

    Refugees seeking asylum are a particularly vulnerable population. It has been observed that among the most commonly-occurring disorders exhibited in this population, there is a high incidence of post-traumatic stress disorder, generalized anxiety disorder, and depression. These disorders may be linked to the difficult paths that refugees are forced to undertake, as well as to different traumatic events which are particularly destructive psychologically (deliberate physical, sexual and/or psychological violence, traumatic bereavements in the context of war, or social and political instability, socio-economic, familial or administrative difficulties), which compromise their view of their short-term futures. In the face of the weight of these life events, the question of the psychological resources of the individual is at the forefront of our understanding of mental health and the capacity to adjust to trauma. Our study aims to apprehend in a dynamic way, the different strategies used by asylum seekers in our western countries to adjust psychologically to traumatic and stressful events. The aim of this research is to study the links between mental health and anxious and depressive psychopathologies as well as the defensive modalities of these subjects. One hundred and twenty adult asylum seekers, living in refugee centres in Slovakia, France and Norway have agreed to participate in this study. We tried to assess the psychopathological disorders manifesting in these populations, notably PTSD, major depression and generalized anxiety disorder. Using the DSQ-60 we also tried to establish the links between the psychopathologies observed in this population and the defence mechanisms employed. Our results reveal that 60% of subjects do indeed suffer from psychopathological disorders with an important comorbidity of PTSB and depression (64.2%). Furthermore, the seriousness of the symptoms is correlated with less adaptive defence mechanisms (a higher incidence of defence

  4. Punished for Persecution: An Analysis of the Criminalization of the Asylum Seeker in the United Kingdom

    OpenAIRE

    Haglund, Molly Grace

    2012-01-01

    Far from a welcoming and humane reception, those seeking asylum within the United Kingdom are confronted with obstacles at all levels of their search for protection. Rather than fulfill their responsibilities to refugees, the UK has sought to avoid its international legal obligations through the implementation of deterrence policies—practices that seek to evade and deny the offering of protection at various levels of the asylum process. These policies not only actively oppose the best inter...

  5. From commitment to compliance? Norway's international human rights obligations and practice towards asylum seekers

    OpenAIRE

    Hermansen, Tonje Falstad

    2015-01-01

    This dissertation examines what international human rights obligations Norway has towards asylum seekers through international treaties and conventions and its compliance with these obligations. The study applies case study methodology and through four cases it lays out some of the disputes between the Norwegian government and asylum authorities, and human rights advocates such as NGOs and lawyers. The theoretical framework for the dissertation is compliance theory which focuses on how states...

  6. Prejudice against and discrimination of asylum seekers: Their antecedents and consequences in a longitudinal field study

    OpenAIRE

    Geschke, Daniel

    2007-01-01

    Prejudice towards and discrimination of migrants are serious problems in our modern, globalised world. In the present doctoral thesis it was studied how negative attitudes of citizens towards asylum seekers relate to contact experiences, feelings of threat and acculturation orientations. A longitudinal field study with two measurement points was conducted with the German inhabitants (N = 70) of a neighbourhood where an asylum seekers refuge was soon to be opened. Directly before and six month...

  7. Health services for asylum seekers and refugees in Europe: consequences for policymaking.

    OpenAIRE

    Devillé, W.; Goosen, S.

    2006-01-01

    Reception and integration of asylum seekers and refugees are high on the political agenda in most European countries. Reception conditions, including the provision of health care, differ considerably between countries. The European Commission tries to harmonise the reception standards in the European countries. This is done for example by launching the EU Reception Conditions Directive (Directive 2003/9/EC), which defines minimum standards on the reception of asylum applicants. This directive...

  8. Asylum recognition rates in Western Europe : their determinants, variation, and lack of convergence

    OpenAIRE

    Neumayer, Eric

    2005-01-01

    Substantial variation in recognition rates for asylum claims from the same countries of origin and therefore prima facie equal merit subjects refugees to unfair and discriminatory treatment. This article demonstrates the extent of variation and lack of convergence over the period 1980 to 1999 across Western European destination countries. Refugee interest groups also suspect that political and economic conditions in destination countries as well as the number of past asylum claims unduly impa...

  9. Why and how there should be more Europe in asylum policies

    OpenAIRE

    Berger, Melissa; Heinemann, Friedrich

    2016-01-01

    The experiences of the ongoing refugee crisis in Europe highlight the failures of the current model of having the EU and its members states share responsibility for asylum policies. Based on standard criteria of fiscal federalism, this paper analyses the shortcomings of the status quo. We show that European asylum policies stand in sharp contradiction to the optimal assignment of tasks within a federal system. For example, the current system creates substantial incentives for free-riding and ...

  10. EU common policy on illegal immigration and asylum: adding to the copenhagen school

    OpenAIRE

    Karadağ, Sibel; Karadag, Sibel

    2012-01-01

    This study is on the common policy of the European Union on illegal immigration and asylum. It particularly explores the adaptability of the Copenhagen School's securitization theory in the context of European immigration policy. The study examines a central puzzle: although the representation of illegal immigrants and asylum seekers as an existential threat has been securitized at the discursive level, this has not contributed to extraordinary measures in the course of the European integrati...

  11. Mental Health and asylum seekers/refugees – interview based research

    OpenAIRE

    MGuiness, Rachael

    2010-01-01

    Abstract Background The number of asylum seekers, refugees and internally displaced people worldwide is continually growing. Alongside this, increasingly restrictive policies are being developed, limiting access to support and healthcare and also enforcing detention and destitution on those seeking asylum in the U.K. The adverse effects these policies have on a person’s emotional and psychological health can cause further distress to this population who have already experienced overwhe...

  12. Measuring common standards and equal responsibility-sharing in EU asylum outcome data

    OpenAIRE

    Luc Bovens; Chlump Chatkupt; Laura Smead

    2012-01-01

    We construct novel measures to assess (i) the extent to which European Union member states are using common standards in recognizing asylum seekers and (ii) the extent to which the responsibilities for asylum applications, acceptances and refugee populations are equally shared among the member states, taking into account population size, gross domestic product (GDP) and GDP expressed in purchasing power parity (GDP-PPP). We track the progression of these measures since the implementation of t...

  13. School and Community-Based Interventions for Refugee and Asylum Seeking Children: A Systematic Review

    OpenAIRE

    Tyrer, Rebecca A.; Mina Fazel

    2014-01-01

    Background Research for effective psychological interventions for refugee and asylum-seeking children has intensified. The need for interventions in environments more easily accessed by children and families is especially relevant for newly arrived populations. This paper reviews the literature on school and community-based interventions aimed at reducing psychological disorders in refugee and asylum-seeking children. Methods and Findings Comprehensive searches were conducted in seven databas...

  14. A Longitudinal Study of Changes in Asylum Seekers Ability Regarding Activities of Daily Living During Their Stay in the Asylum Center

    DEFF Research Database (Denmark)

    Morville, Anne-Le; Amris, Kirstine; Eklund, Mona; Danneskiold-Samsøe, Bente; Erlandsson, Lena-Karin

    2015-01-01

    The aim was to assess change in activities of daily living (ADL) ability amongst asylum seekers and if there were any difference between tortured and non-torture following a 10 months post-arrival period, and if self-reported health and exposure to torture were factors related to change in ADL......-ability. The study was a combined baseline, follow-up correlational study amongst individuals from Afghanistan, Iran and Syria, living in Danish asylum centers. Forty-three persons aged 20-50, were invited and participated in the baseline study. Twenty-two were still in asylum center at the follow-up and 17 of...... depression increased. Exposure to physical torture and change in ADL motor (r = 0.525) measures were associated, as well as change in current pain and change in ADL process (r = 0.525) measures. Due to preponderance of torture survivors analysis of group difference was not applicable. Health care workers...

  15. [Taking Care of Asylum Seekers: Occupational Health Aspects with a Special Focus on Vaccination].

    Science.gov (United States)

    Kolb, S; Hörmansdorfer, S; Ackermann, N; Höller, C; Brenner, B; Herr, C

    2016-04-01

    Employees and volunteers often feel insecure about the potential transmission of infectious diseases when taking care of asylum seekers. It could be shown that overall only a minor risk of infection emanates from asylum seekers. However, aspects of occupational health and vaccination should be kept in mind.Besides the standard vaccination the Standing Committee on Vaccination (STIKO) recommends for occupational indication, which is given for employees and volunteers in asylum facilities, vaccination against hepatitis A, hepatitis B, polio (if the last vaccination was more than 10 years before) as well as influenza (seasonal).According to the German Occupational Safety and Health Act taking care of the employer has to determine which exposures might occur at the workplace (risk assessment) and define necessary protection measures. Depending on task and exposure when taking care of asylum seekers different acts (e. g. biological agents regulation) and technical guidelines for the handling biological agents (e. g. TRBA 250 or TRBA 500) have to be applied.The Bavarian Health and Food Safety Authority (LGL) has published several information sheets regarding "asylum seekers and health management" for employees and volunteers from the non-medical as well as the medical area (www.lgl.bayern.de search term "Asylbewerber"). With theses publications insecurities in taking care of asylum seekers should be prevented. Furthermore the employer gets support in the implementation of legal obligations to ensure occupational safety for the employees. PMID:27078829

  16. Seroprevalence of Hepatitis B, C and HIV/AIDS in Asylum Seekers in Istanbul

    Directory of Open Access Journals (Sweden)

    Kadriye Kart Yaşar

    2014-03-01

    Full Text Available Objective:This study aimed to determine prevalence of hepatitis B, C and HIV/AIDS in asylum seekers in Istanbul, Turkey. Methods: The data about asylum seekers who applied in Istanbul between March 2008 and March 2010 were evaluated retrospectively. Demographic features and markers of blood borne infections (HBsAg, anti-HCV and anti-HIV results of asylum seekers were reviewed. Results: In total 3043 asylum seekers were included into the study. The leading origin countries of the refugees were from Afghanistan, Turkmenistan and Azerbaijan and majority of them (2328 people, 77% were male. The young adults between 25 and 45 years constituted the most crowded group. Overall prevalence of HCV, HBsAg and HIV/AIDS were 12.2%, 5.9% and 0.7%, respectively. The highest seropositivity rate for anti-HCV, HBsAg and anti-HIV were found in Georgian males (47.1%; in Moldovan males (13.2% and in Somali males (3.1%, respectively. Conclusion:Mostly asylum seekers who have migrated to our country were young adult males from Asia. The highest prevalence rate of HCV was found in Georgian males. Therefore, the increased potential of migration to our country along the recent years necessitates development of an appropriate health approach concerning asylum seekers. J Microbiol Infect Dis 2014;4(1: 20-25

  17. Book review: who is worthy of protection? Gender-based asylum and US immigration politics by Meghana Nayak

    OpenAIRE

    Kao, M. Bob

    2016-01-01

    In Who is Worthy of Protection? Gender-Based Asylum and US Immigration Politics, Meghana Nayak examines gender-based asylum in the United States, focusing on the narratives through which certain asylees are framed as being more ‘worthy’ than others. While M. Bob Kao welcomes Nayak’s recommendations regarding how feminist scholars can productively intervene in the asylum process, he nonetheless questions whether all of these arguments can be equally put into practice by lawyers navigating the ...

  18. ‚Getting Asylum Seekers into Employment‘? – Ein Allheilmittel für die Europäische Einwanderungspolitik?

    OpenAIRE

    Tausch, Arno

    2012-01-01

    The cross-national empirics of the international asylum system are in their infancy. While Hatton, 2009, and Neumayer, 2005, 2006a and 2006b provided important and valuable cross-national insights on the drivers of the asylum seeking process, as yet little is known in terms of hard-core evidence about the effects of asylum-driven migration processes on the recipient countries. But such analyses are necessary, since asylum plays such an important role in the overall South-North migration proce...

  19. After Wilberforce : an independent enquiry into the health and social needs of asylum seekers and refugees in Hull.

    OpenAIRE

    Campion, P; Brown, S. R.; Thornton-Jones, H.

    2010-01-01

    Commissioned by NHS Hull, this project has four aims: a. to gather the views of asylum seekers and refugees in Hull about their lives, and health; b. to consult with all relevant agencies in the city concerned with the health and social care of asylum seekers and refugees; c. to identify best practice in asylum seeker and refugee care in other parts of the country; d. to propose a strategy for the health and social care of asylum seekers and refugees in Hull. We car...

  20. LIFE IN A BACKPACK: THE EU’S ASYLUM POLICIES AND ITS IMPACT ON THE MACEDONIAN ASYLUM LEGISLATION

    Directory of Open Access Journals (Sweden)

    Angelina Stanojoska

    2015-09-01

    Full Text Available Starting the Arab spring in 2010 and going through the latest and ongoing Syrian conflict and crises, Balkans and Macedonian railways have been and are a place where many human destinies cross their paths walking to the Member States of the European Union. On the other side, Macedonia is struggling with an influx of refugees, finding itself in a status quo position, even looking as it does not know how to solve the situation. Migrants were killed on railways every day not being able to use any kind of public transportation; their smuggling became a normal business for organized crime groups; Macedonian citizens started to earn money on refugees’ misfortune. The paper using the comparative method and document analysis, gives an overview of the EU’s legislation in the area, its improvement and current impact on things, all of it concluded with the Macedonian legal solutions regarding asylum and authors’ recommendations.

  1. miRSeqNovel

    DEFF Research Database (Denmark)

    Qian, Kui; Auvinen, Eeva; Greco, Dario;

    2012-01-01

    We present miRSeqNovel, an R based workflow for miRNA sequencing data analysis. miRSeqNovel can process both colorspace (SOLiD) and basespace (Illumina/Solexa) data by different mapping algorithms. It finds differentially expressed miRNAs and gives conservative prediction of novel miRNA candidates...... with customized parameters. miRSeqNovel is freely available at http://sourceforge.net/projects/mirseq/files....

  2. Narrative survival: personal and institutional accounts of asylum confinement.

    Science.gov (United States)

    Hanganu-Bresch, Cristina; Berkenkotter, Carol

    2012-01-01

    This essay has been conceptually eclectic in that we have integrated concepts from genre theory and discourse analysis. In our interpretation of Merivale and Marshall's narratives, we have also drawn upon Frye's Anatomy of criticism, a canonical text in literary genre theory. Such an eclectic approach seems warranted by both the contextual and textual features of Merivale's and Marshall's narratives, and in particular by Merivale's use of Mennipean satire with its encyclopedic detail. In our discussion of Merivale and Marshall's Admissions Records we have drawn on speech act theory to suggest that the Order (to admit a patient), the two medical certificates that follow, and finally, the notice to admit a patient constitute a constellation of texts, a genre suite, with a powerful illocutionary force. These texts are the prelude to and the means of confinement; they are both act and process. At the heart of our comparison of the asylum records of Merivale and Marshall with their "survivor narratives" is our analytic conclusion that the Ticehurst case histories can be said to constitute a linear "chronicle" of what Hayes Newington, the writer of the two case histories observed and inferred about his two patients. As chronicles, the Ticehurst Asylum case histories are linear representations or realistic accounts. As such, these archival documents provide a genuine insight into the "ways that that reality offers itself to perception". The institutional accounts exist in--and mark a--"flat time," equalized by each dated entry depicting the writer's mechanical act of observing/noting in brief, stereotypical sentences, e.g., "Patient is better [or, conversely, no] better today." We dubbed this metronomic time: beating regularly and evenly, flattening out the individual trajectories of each patient's illness. Metronomic time is normative. Each beat is calculated precisely to be the same as next. The dispassionate nature of clinical observations and the metronymic rhythms of

  3. No Time for Nostalgia!: Asylum-Making, Medicalized Colonialism in British Columbia (1859-97) and Artistic Praxis for Social Transformation

    Science.gov (United States)

    Roman, Leslie G.; Brown, Sheena; Noble, Steven; Wainer, Rafael; Young, Alannah Earl

    2009-01-01

    This article asks: How have disability, indigenous arts and cultural praxis transformed and challenged the historical sociological archival research into relationships among asylum-making, medicalized colonialism and eugenics in the Woodlands School, formerly the Victoria Lunatic Asylum, the Provincial Asylum for the Insane in Victoria, BC 1859-72…

  4. The common European asylum system and the rights of the child : an exploration of meaning and compliance

    NARCIS (Netherlands)

    Smyth, Ciara Mary

    2013-01-01

    This thesis addresses the question of whether the EU Common European Asylum System (CEAS) complies with the rights of the child. A significant proportion of people seeking asylum in EU countries are children. These children may be totally alone, with people who are not their customary caregivers o

  5. Credibility Assessments as 'Normative Leakage': Asylum Applications, Gender and Class

    Directory of Open Access Journals (Sweden)

    Hanna Wikström

    2013-10-01

    Full Text Available Based on the assumption that credibility assessments function as 'normative leakage' within the asylum process, we analyse how narratives of gender and class are articulated, rendered meaningful, or silenced in credibility assessments. Two cases concerning male applicants are selected in order to illustrate these processes. In relation to the existing concepts of internal/external credibility, we wish to introduce the concept of social credibility, which focuses on how the assessors read different socio-cultural narratives. While previous research has shown that the postcolonial will to protect women favours women as victims of patriarchal cultures, we wish to point out the continuity of this line of argumentation in relation to male and female applicants by adopting a theoretical generalization: male applicants instead become situated at the other end of the spectrum of postcolonial notions of modernity as non-victims, victims of other circumstances or perpetrators. We argue that these processes are accentuated in relation to credibility assessments. In order to prevent processes of social exclusion and to enhance inclusive practice, authorities need to acknowledge the 'normative leakage' associated with the assessment process.

  6. The Relationship Between Post-Migration Stress and Psychological Disorders in Refugees and Asylum Seekers.

    Science.gov (United States)

    Li, Susan S Y; Liddell, Belinda J; Nickerson, Angela

    2016-09-01

    Refugees demonstrate high rates of post-traumatic stress disorder (PTSD) and other psychological disorders. The recent increase in forcible displacement internationally necessitates the understanding of factors associated with refugee mental health. While pre-migration trauma is recognized as a key predictor of mental health outcomes in refugees and asylum seekers, research has increasingly focused on the psychological effects of post-migration stressors in the settlement environment. This article reviews the research evidence linking post-migration factors and mental health outcomes in refugees and asylum seekers. Findings indicate that socioeconomic, social, and interpersonal factors, as well as factors relating to the asylum process and immigration policy affect the psychological functioning of refugees. Limitations of the existing literature and future directions for research are discussed, along with implications for treatment and policy. PMID:27436307

  7. [Asylum-seekers' mental and physical health problems: practices and recommendations].

    Science.gov (United States)

    Kórász, Krisztián

    2016-01-01

    The Hungarian health care system faces new challenges with the unprecedented increased rate of migration. Asylum-seekers arriving are a heterogeneous group. Their health care needs vary depending on their country of origin and the quality of the health care they received prior to arrival, not to mention the impact of the migration process on their health. Described within this paper are the challenges an asylum seeker might face in obtaining care on arrival into the host country and the challenges clinicians face in providing that care. This review is designed to give health professionals the necessary knowledge to care for asylum-seekers in a culturally aware and clinically informed manner. PMID:26708683

  8. Will a Quota Plan for Asylum Seekers Plan Work —and Why Not?

    DEFF Research Database (Denmark)

    Seeberg, Peter

    The article describes the recent situation in the Mediterranean, where the number of asylum seekers arriving from countries south and east of the Mediterranean Sea is increasing significantly. The European Commission has suggested a plan, “A European Agenda on Migration”, which will redistribute...... idea from the EU-Commission of a mandatory quota plan for asylum seekers will not work, because too many states will pretend, that the problem does not really belong to them. They fear that accepting a system according to which each state has to accept a fixed quota of asylum seekers in a recent...... context might later on lead to a common EU migra-tion policy, which are beyond national control and would make it difficult to avoid responsibilities for internal crisis situations emerging in other parts of the Middle East or North Africa in the future....

  9. Morbidity of asylum seekers in a medium-sized German city.

    Science.gov (United States)

    Führer, Amand; Eichner, Friederike; Stang, Andreas

    2016-07-01

    Asylum seekers constitute a particularly vulnerable group. Not only is their physical and mental health exposed to multiple stresses, but also their access to health care in Germany is legally restricted. Up to now, there is very limited scientific literature investigating the health-outcomes of asylum seekers in Germany. The aim of this study was to provide prevalence data on the morbidity and vaccination status of asylum seekers in a medium-sized German city. We used a structured questionnaire in a cross-sectional study on 214 adult asylum seekers (182 males, 24 females, 8 unknown) in Halle, Germany, 2015. The questionnaire inquired about the respondent's self-reported physical health and vaccination status and assessed their mental health using the Hopkins-Symptom-Checklist-25 and the Harvard Trauma Questionnaire. Pain (37.9 %) and psychological illness (depression: 54.7 %, anxiety disorder: 40.2 %; post-traumatic stress disorder: 18.2 %) were the most prevalent complaints. Among asylum seekers with psychological complaints, co-morbidity was high (64.2 % had more than one psychological disease). 5.6 % of the respondents mentioned suicidal thoughts. The prevalence of chronic diseases was low. We suggest interventions to improve asylum seekers' health on two levels: first, the obligatory initial medical examination after the refugees' arrival at the reception centre should be complemented with questions related to the vaccination status and the most common complaints including pain and psychological diseases. Second, medical infrastructure should be expanded to better serve the needs of culturally and linguistically diverse patient populations, so that those screened positive can be referred for early diagnosis and treatment. PMID:27068422

  10. The European Union and refugees: towards more restrictive asylum policies in the European Union?

    OpenAIRE

    Kaunert, Christian; L??onard, Sarah

    2011-01-01

    Several scholars have argued that European countries have decided to cooperate on asylum and migration matters at the EU level in order to develop more restrictive policies. In particular, it has been argued that European states have ???venue-shopped??? to a new policy-venue in order to escape national constraints. This paper puts this argument to the test by assessing the extent to which the development of EU cooperation on asylum matters has indeed led to the adoption of more restrictive as...

  11. Female genital mutilation, asylum seekers and refugees: the need for an integrated European Union agenda.

    Science.gov (United States)

    Powell, Richard A; Leye, Els; Jayakody, Amanda; Mwangi-Powell, Faith N; Morison, Linda

    2004-11-01

    Asylum seekers and refugees (ASRs) are a heterogeneous population with distinct physical and psychological needs. ASRs with additional health needs are girls and women who have undergone, or are at risk of undergoing, female genital mutilation (FGM). Across the European Union (EU), variation exists in Member States' anti-FGM and asylum legislation, the rigour of existing research programmes, and the operational coherence of the multiple agencies combating the practice. ASRs' needs are, consequently, not being addressed satisfactorily. This paper proposes an integrated future agenda, applicable in all EU countries, capable of meeting these girls' and women's needs. PMID:15364145

  12. The Grassroots Pro-Asylum Seeker Movement in the Republic of Ireland: A Social Movement Perspective

    OpenAIRE

    Moran, Niall

    2011-01-01

    This thesis is an in-depth analysis of the Grassroots Pro-Asylum Seeker Movement in the Republic of Ireland between 1994 and 2004. It seeks to understand and analyse this development of the Grassroots Pro-Asylum Seeker Movement in Ireland from a social movement perspective. The movement itself contains three key phases of mobilisation: 1) Radical Anti-Racism; 2) The Multicultural Support Group and; 3) The Anti-Deportation Group. Each of these phases is described in detail in th...

  13. Pharmaco-miR

    DEFF Research Database (Denmark)

    Rukov, Jakob Lewin; Wilentzik, Roni; Jaffe, Ishai;

    2014-01-01

    MicroRNAs (miRNAs) are short regulatory RNAs that down-regulate gene expression. They are essential for cell homeostasis and active in many disease states. A major discovery is the ability of miRNAs to determine the efficacy of drugs, which has given rise to the field of 'miRNA pharmacogenomics......' through 'Pharmaco-miRs'. miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. These interactions can be described as triplet sets consisting of a miRNA, a target gene and a drug associated with the gene. We have developed a web server which...... links miRNA expression and drug function by combining data on miRNA targeting and protein-drug interactions. miRNA targeting information derive from both experimental data and computational predictions, and protein-drug interactions are annotated by the Pharmacogenomics Knowledge base (Pharm...

  14. How do NGO's influence asylum policies in Norway? : a case study on the White paper, "Children on the run"

    OpenAIRE

    Koschnick, Katharina

    2013-01-01

    To which extent are NGO’s able to influence immigration and asylum policies in Norway? As important actors in Norway’s immigration and asylum politics, NGO’s had huge interests in a new white paper (white paper 27, “Children on the run”) that aimed to improve living situations of child asylum seekers in Norway, and thus used their resources intensively for lobbying politicians. This research paper employed a case study that analyzed NGO’s potential to influence governmental policies versus NG...

  15. Dermatological problems of asylum seekers arriving on boats: a case report from Australia and a brief review.

    Science.gov (United States)

    Cheng, Hui Mei; Kumarasinghe, Sujith Prasad

    2014-11-01

    Assessing the skin of asylum seekers, immigrants, migrant workers, tourists or even locals who return from abroad, can be a confronting task due to the possibility of such people having non-autochthonous diseases. Primary-care physicians and dermatologists need to have a systematic approach in the assessment of such dermatoses. This article describes an interesting case of possible kerosene-induced and diesel-induced skin injury in an asylum seeker arriving on a boat. Dermatological conditions in asylum seekers and a suggested template for skin assessment are discussed. PMID:25178452

  16. Safe in our hands?: a study of suicide and self-harm in asylum seekers.

    Science.gov (United States)

    Cohen, Juliet

    2008-05-01

    This study examined the incidence of suicide and self-harm in asylum seekers in the UK, both those in detention and in the community. The investigation revealed that data recording is seriously flawed or sometimes non-existent. However, the scanty data those were available from Immigration Removal Centres, coroners' records and Prison Ombudsman's reports showed high levels of self-harm and suicide for detained asylum seekers as compared with the United Kingdom prison population. It is suggested that this could be attributed to routine failure to observe and mitigate risk factors. The author makes the following recommendations: coroners should record asylum seeker status and ethnicity of deceased, self-harm monitoring in the community should record asylum seeker status and ethnicity, health care in immigration removal centres should meet the same standards as UK prisons as a minimum, allegation of torture by immigration detainees should trigger a case management review and risk assessment for continued detention, and this process should be open to audit, and interpreters should be used for mental state examinations unless their English has been shown to the fluent. PMID:18423357

  17. Sexual and gender-based violence in the European asylum and reception sector: a perpetuum mobile?

    NARCIS (Netherlands)

    Keygnaert, I.; Dias, S.F.; Degomme, O.; Devillé, W.; Kennedy, P.; Kovats, A.; Meyer, S. de; Vettenburg, N.; Roelens, K.; Temmerman, M.

    2015-01-01

    Background: Refugees, asylum seekers and undocumented migrants are at risk of sexual and gender-based violence (SGBV) and subsequent ill-health in Europe; yet, European minimum reception standards do not address SGBV. Hence, this paper explores the nature of SGBV occurring in this sector and discuss

  18. Sexual and gender-based violence in the European asylum and reception sector: a perpetuum mobile?

    NARCIS (Netherlands)

    I. Keygnaert; S.F. Dias; O. Degomme; W. Devillé; P. Kennedy; A. Kováts; S. De Meyer; N. Vettenburg; K. Roelens; M. Temmerman

    2014-01-01

    Background: Refugees, asylum seekers and undocumented migrants are at risk of sexual and gender-based violence (SGBV) and subsequent ill-health in Europe; yet, European minimum reception standards do not address SGBV. Hence, this paper explores the nature of SGBV occurring in this sector and discuss

  19. Asylum Seekers and Resettled Refugees in Australia: Predicting Social Policy Attitude From Prejudice Versus Emotion

    Directory of Open Access Journals (Sweden)

    Lisa K. Hartley

    2015-07-01

    Full Text Available While most of the world's refugees reside in developing countries, their arrival to western countries is highly politicised, giving rise to questions about the types of entitlements and rights that should, or should not, be granted. In this study, using a mixed-methods community questionnaire (N = 185, we examined attitudes towards social policies aimed at providing assistance to two categories of new arrivals to Australia: resettled refugees (who arrive via its official refugee resettlement program and asylum seekers (who arrive via boat and then seek refugee status. Social policy attitude was examined as a consequence of feelings of anger, fear, and threat, as well as levels of prejudice. Participants felt significantly higher levels of anger, fear, threat, and prejudice towards asylum seekers compared to resettled refugees. For both resettled refugees and asylum seekers, prejudice was an independent predictor of more restrictive social policy attitudes. For resettled refugees, fear and perceived threat were independent predictors for more restrictive social policy whereas for asylum seekers anger was an independent predictor of restrictive social policy. The qualitative data reinforced the quantitative findings and extended understanding on the appraisals that underpin negative attitudes and emotional responses. Practical implications relating to challenging community attitudes are discussed.

  20. Experiences of Young (Minor) Asylum Seekers in Further Education in Malta

    Science.gov (United States)

    Spiteri, Damian

    2015-01-01

    This study appraises the particular challenges that minor asylum-seeking migrants who are in the 16-18 age category confront when pursuing their studies in a vocational college in Malta, a central Mediterranean island which is the smallest EU member state. The study explores how they exercise resilience in their desire to forge a future for…

  1. When Children Seek Asylum from Their Parents: A Canadian Case Study

    Science.gov (United States)

    Bossin, Michael; Demirdache, Laila

    2012-01-01

    When children seek asylum from alleged abuse by a custodial parent, the notion that family reunification is always in the best interests of independent child migrants is undermined. In this chapter, the authors discuss the legal tensions between the Refugee Convention, the Convention on the Civil Aspects of International Child Abduction (the…

  2. Waiting Time: The De-Subjectification of Children in Danish Asylum Centres

    Science.gov (United States)

    Vitus, Kathrine

    2010-01-01

    This article analyses the relationship between time and subjectification, focusing on the temporal structures created within Danish asylum centres and politics, and on children's experiences of and reactions to open-ended waiting. Such waiting leads to existential boredom which manifests in the children as restlessness, fatigue and despair. The…

  3. Unaccompanied adolescents seeking asylum : poorer mental health under a restrictive reception

    NARCIS (Netherlands)

    Reijneveld, S.A.; de Boer, J.B.; Bean, T.; Korfker, D.G.

    2005-01-01

    We assessed the effects of a stringent reception policy on the mental health of unaccompanied adolescent asylum seekers by comparing the mental health of adolescents in a restricted campus reception setting and in a setting offering more autonomy (numbers [response rates]: 69 [93%] and 53 [69%], res

  4. Recording the many face of death at the Denbigh Asylum, 1848-1938.

    Science.gov (United States)

    Michael, Pamela; Hirst, David

    2012-03-01

    The funeral was a symbolic event in Welsh society, and members of staff and relatives of patients at the Denbigh Asylum shared cultural assumptions about the importance of a final resting place for the body. Formal procedures following the death of a patient were governed by asylum rules and regulations. A Denbigh the asylum chaplain played an important role, both in terms of ministering to the dying and I performing the funeral ceremony. During the late nineteenth century the burial ground became a conteste space as nonconformists and Roman Catholics fought against the ascendancy of the Anglican Church in Wale and demanded that patients be buried according to their religious affiliation. The lunatic asylum became a sit for advancing the case for Welsh disestablishment. By the twentieth century, infectious diseases had become a serious concern, and the need to carry out screening and conduct post-mortem examinations resulted in the appointment of a pathologist, whose main role was to conduct biological and histological examinations to identify cases of tuberculosis, syphilis, dysentery, typhoid, influenza and other bodily diseases. PMID:22701926

  5. Policies of exclusion and practices of inclusion: how municipal governments negotiate asylum policies in the Netherlands

    NARCIS (Netherlands)

    S. Kos; M. Maussen; J. Doomernik

    2015-01-01

    There is a major gap in Dutch refugee and immigration control policies between its ambitions and outcomes. It results in considerable numbers of rejected asylum seekers who, while they cannot be expelled from the country, are excluded from government support and from opportunities to work in the bel

  6. Gender Variation in Asylum Experiences in the UK: The Role of Patriarchy and Coping Strategies

    Directory of Open Access Journals (Sweden)

    Ruth L. HEALEY

    2010-11-01

    Full Text Available Previous work suggests that female asylum seekers and refugees have more constraints on their actions than their male counterparts, as structural forces from the country of origin are reproduced in the host country. This paper explores the use of structuration theory in interpreting the impact of gender upon asylum seeker and refugee experiences in the UK. The experiences of, and coping strategies used by 8 male and 10 female asylum seekers and refugees from two different cities are analysed. Their experiences are examined in relation to different patriarchal forces. In comparison to the males, differences are apparent in the level and types of agency of the female asylum seekers and refugees. Within this study certain types of patriarchy are reproduced in British society particularly at the household level, whilst individuals are also influenced by institutional patriarchy within the wider society. The variation in experiences found here suggests the need for policy to recognise the heterogeneity of these groups, so as to provide the most appropriate support for individuals.

  7. Transnational Migration, State Policy and Local Clinician Treatment of Asylum Seekers and Resettled Migrants

    OpenAIRE

    Koehn, Peter H.

    2006-01-01

    Abstract Based on interviews conducted at five Finnish reception centers and in two municipal communes during summer 2002 with 93 migrants, mainly from a variety of Southern and Eastern countries of origin, and their ethnoculturally discordant clinicians, the article compares asylum seekers and foreign-born residents in terms of health care treatment and outcome perspectives. Comparative analysis suggests t...

  8. Politicised Notions of Professional Identity and Psychosocial Practice among Practitioners Working with Asylum Seekers and Refugees

    Science.gov (United States)

    Apostolidou, Zoe

    2015-01-01

    This is the first study undertaken in the UK that investigates the notion of professional identity among practitioners who work with asylum seekers and refugees. Drawing on a social constructionist epistemology and a Foucauldian theoretical and methodological framework of power and discourse, I analysed extracts from semi-structured interviews…

  9. Comparison of self-reported health & healthcare utilisation between asylum seekers and refugees: an observational study.

    LENUS (Irish Health Repository)

    Toar, Magzoub

    2009-01-01

    BACKGROUND: Adult refugees and asylum seekers living in Western countries experience a high prevalence of mental health problems, especially post traumatic stress disorder (PTSD), depression and anxiety. This study compares and contrasts the prevalence of health problems, and potential risk factors as well as the utilisation of health services by asylum seekers and refugees in the Irish context. METHODS: Cross sectional study using validated self reported health status questionnaires of adult asylum seekers (n = 60) and refugees (n = 28) from 30 countries, living in Ireland. Outcome measures included: general health status (SF-36), presence of PTSD symptoms and anxiety\\/depression symptoms. Data on chronic conditions and pre or post migration stressors are also reported. The two groups are compared for utilisation of the health care system and the use of over the counter medications. RESULTS: Asylum seekers were significantly more likely than refugees to report symptoms of PTSD (OR 6.3, 95% CI: 2.2-17.9) and depression\\/anxiety (OR 5.8, 95% CI: 2.2-15.4), while no significant difference was found in self-reported general health. When adjusted by multivariable regression, the presence of more than one chronic disease (OR 4.0, 95%CI: 1.3-12.7; OR 3.4, 95% CI: 1.2-10.1), high levels of pre migration stressors (OR 3.6, 95% CI: 1.1-11.9; OR 3.3, 95% CI: 1.0-10.4) or post migration stressors (OR 17.3, 95% CI: 4.9-60.8; OR 3.9, 95% CI: 1.2-12.3) were independent predictors of self reported PTSD or depression\\/anxiety symptoms respectively, however, residence status was no longer significantly associated with PTSD or depression\\/anxiety. Residence status may act as a marker for other explanatory variables; our results show it has a strong relationship with post migration stressors (chi2 = 19.74, df = 1, P < 0.001).In terms of health care utilisation, asylum seekers use GP services more often than refugees, while no significant difference was found between these groups

  10. Comparison of self-reported health & healthcare utilisation between asylum seekers and refugees: an observational study

    Directory of Open Access Journals (Sweden)

    Fahey Tom

    2009-06-01

    Full Text Available Abstract Background Adult refugees and asylum seekers living in Western countries experience a high prevalence of mental health problems, especially post traumatic stress disorder (PTSD, depression and anxiety. This study compares and contrasts the prevalence of health problems, and potential risk factors as well as the utilisation of health services by asylum seekers and refugees in the Irish context. Methods Cross sectional study using validated self reported health status questionnaires of adult asylum seekers (n = 60 and refugees (n = 28 from 30 countries, living in Ireland. Outcome measures included: general health status (SF-36, presence of PTSD symptoms and anxiety/depression symptoms. Data on chronic conditions and pre or post migration stressors are also reported. The two groups are compared for utilisation of the health care system and the use of over the counter medications. Results Asylum seekers were significantly more likely than refugees to report symptoms of PTSD (OR 6.3, 95% CI: 2.2–17.9 and depression/anxiety (OR 5.8, 95% CI: 2.2–15.4, while no significant difference was found in self-reported general health. When adjusted by multivariable regression, the presence of more than one chronic disease (OR 4.0, 95%CI: 1.3–12.7; OR 3.4, 95% CI: 1.2–10.1, high levels of pre migration stressors (OR 3.6, 95% CI: 1.1–11.9; OR 3.3, 95% CI: 1.0–10.4 or post migration stressors (OR 17.3, 95% CI: 4.9–60.8; OR 3.9, 95% CI: 1.2–12.3 were independent predictors of self reported PTSD or depression/anxiety symptoms respectively, however, residence status was no longer significantly associated with PTSD or depression/anxiety. Residence status may act as a marker for other explanatory variables; our results show it has a strong relationship with post migration stressors (χ2 = 19.74, df = 1, P In terms of health care utilisation, asylum seekers use GP services more often than refugees, while no significant difference was found

  11. Asylum migration and the construction of the European Common Foreign and Security Policy: evidence from the Greek case

    Directory of Open Access Journals (Sweden)

    Silvia Lucía Forero Castañeda

    2015-12-01

    Full Text Available This article examines how the recent evolution of asylum migration has affected the construction of the European Common Foreign and Security Policy (EU-CFSP, taking the Greek case during the 2001-2012 period as a starting point. With this in mind, the normative progress of the EU-CFSP facing the reception of asylum seekers in Greece is analyzed, under the scope of what Barry Buzan and Ole Waever would call Securitization Process. Both legal and political frameworks on asylum migration in Greece and in the European Union are approached, in the context of the evolution of the EU-CFSP in three main areas: Neighborhood Policy, Development and Cooperation Policy, and Human Rights Protection. The conclusión points toward the partial influence of asylum migration in the configuration of the UE-CFSP during the studied period.

  12. "Their Stories Have Changed My Life": Clinicians' Reflections on Their Experience with and Their Motivation to Conduct Asylum Evaluations.

    Science.gov (United States)

    Mishori, Ranit; Hannaford, Alisse; Mujawar, Imran; Ferdowsian, Hope; Kureshi, Sarah

    2016-02-01

    Many clinicians perform asylum evaluations yet no studies describe the motivation to perform them or their perceived rewards. The number of asylum seekers in the US is increasing and more clinicians are needed as evaluators. A survey to an asylum evaluators' network asked participants to qualitatively reflect on their experience and motivation. Answers were analyzed for themes and sentiment. Respondents cited commitment to humanistic and moral values, noted personal and family experiences, having skills, expertise, and career interests as drivers. They found the experience very rewarding personally and professionally, and in their perceived benefit to asylees. Negative sentiment was less frequent and centered on emotions related to client narratives. Process-oriented frustrations were also noted. This is the first published study describing clinicians' motivation and experience with asylum evaluations. It may illuminate clinicians' drive to volunteer, and serve as a resource for organizations for recruitment and education. PMID:25527443

  13. Health literacy and refugees' experiences of the health examination for asylum seekers : a Swedish cross-sectional study

    OpenAIRE

    Wångdahl, Josefin; Lytsy, Per; Mårtensson, Lena; Westerling, Ragnar

    2015-01-01

    Background The purpose of the health examination for asylum seekers in most countries is to identify poor health in order to secure the well-being of seekers of asylum and to guarantee the safety of the population in the host country. Functional health literacy is an individual’s ability to read information and instructions about health and to function effectively as a patient in the health system, and comprehensive health literacy is an individual’s competence in accessing, understanding, ap...

  14. Asylum, immigration restrictions and exploitation: hyper-precarity as a lens for understanding and tackling forced labour

    OpenAIRE

    Lewis, H; Waite, L

    2015-01-01

    The topic of forced labour is receiving a growing amount of political and policy attention across the globe. This paper makes two clear contributions to emerging debates. First, we focus on a group who are seldom explicitly considered in forced labour debates; forced migrants who interact with the asylum system. We build an argument of the production of susceptibility to forced labour through the UK’s asylum system, discussing the roles of compromised socio-legal status resulting from restric...

  15. Adult Asylum Seekers from the Middle East Including Syria in Central Europe: What Are Their Health Care Problems?

    OpenAIRE

    Pfortmüller, Carmen; Schwetlick, Miriam; Müller, Thomas; Lehmann, Beat; Exadaktylos, Aristomenis

    2016-01-01

    Background Forced displacement related to persecution and violent conflict has reached a new peak in recent years. The primary aim of this study is to provide an initial overview of the acute and chronic health care problems of asylum seekers from the Middle East, with special emphasis on asylum seekers from Syria. Methods Our retrospective data analysis comprised adult patients presenting to our emergency department between 01.11.2011 and 30.06.2014 with the official resident sta...

  16. Stool screening of Syrian refugees and asylum seekers in Germany, 2013/2014: Identification of Sabin like polioviruses.

    Science.gov (United States)

    Böttcher, Sindy; Neubauer, Katrin; Baillot, Armin; Rieder, Gabriele; Adam, Maja; Diedrich, Sabine

    2015-10-01

    Germany is a partner of the Global Polio Eradication Initiative. Assurance of polio free status is based on enterovirus surveillance, which focuses on patients with signs of acute flaccid paralysis or aseptic meningitis/encephalitis, representing the key symptoms of poliovirus infection. In response to the wild poliovirus outbreak in Syria 2013 and high number of refugees coming from Syria to Germany, stool samples from 629 Syrian refugees/asylum seekers aged refugees and asylum seekers at that time. PMID:26321005

  17. The common European asylum system and the rights of the child: an exploration of meaning and compliance

    OpenAIRE

    Smyth, Ciara Mary

    2013-01-01

    This thesis addresses the question of whether the EU Common European Asylum System (CEAS) complies with the rights of the child. A significant proportion of people seeking asylum in EU countries are children. These children may be totally alone, with people who are not their customary caregivers or with members of their immediate family. In recognition of this phenomenon, the instruments that make up the CEAS often make specific provision for children, demonstrating an awareness on the part o...

  18. miRMaid

    DEFF Research Database (Denmark)

    Jacobsen, Anders; Krogh, Anders; Kauppinen, Sakari;

    2010-01-01

    ABSTRACT: BACKGROUND: MicroRNAs (miRNAs) are endogenous small RNAs that play a key role in post-transcriptional regulation of gene expression in animals and plants. The number of known miRNAs has increased rapidly over the years. The current release (version 14.0) of miRBase, the central online...... complex questions involving the multitude of miRNA data resources. Furthermore, miRMaid constitutes a basic framework for further programming in which microRNA-interested bioinformaticians can readily develop their own tools and data sources....

  19. HIV positive asylum seekers receiving the order to leave the Belgian territory

    Directory of Open Access Journals (Sweden)

    Remy Demeester

    2014-11-01

    Full Text Available Introduction: In a human rights based approach, the Parliamentary Assembly of the Council of Europe has recently released a resolution about migrants and refugees and the fight against HIV (1. It states that “an HIV positive migrant should never be expelled when it is clear that he will not receive adequate health care and assistance in the country to which he is being sent back. To do otherwise would amount to a death sentence for that person.” Nevertheless, in Belgium, for the last 2 years, none of the HIV-infected migrants in care in the AIDS Reference Centers (ARC received the right to stay in Belgium for medical reasons. Methods: We identified all HIV-infected asylum seekers in care between 1 July 2012 and 1 July 2014 in the ARC of Charleroi, Belgium, and we analyzed their medical and social files. Results: Among the 302 patients in active follow up in our ARC, 45 HIV positive asylum seekers were in care during the last 2 years. Male/female ratio was 0/96. Mean age was 35 years. Countries of origin and reasons for migration are detailed in the Table 1. 18% (8/45 knew their seropositivity before arriving in Europe. All the patients introduced an asylum request, 29 (64% have received a negative answer and an order to leave the territory, 4 (9% were regularized for non-medical reasons (see Table 1, 4 (9% are waiting for an answer and for 8 (18% outcome is unknown due to lost follow up (LFU. 31 (69% patients have also introduced a request to stay for medical reasons: 18 (58% have received a refusal, 7 (23% are still waiting for an answer, and 6 (19% are LFU. Only 23 (51% patients are still in care in our ARC on 1 July 2014 (see Table 1. The immigration office bases its decisions on availability of the treatment in the country even if accessible only to a limited number of patients. Conclusions: Decisions taken by the Belgian authorities for the last two years concerning HIV-infected asylum seekers do not guarantee the continuity of care of

  20. National encounters and institutional states of exception : the US insane asylum and the first-person reform writing of mad women, 1844-1897

    OpenAIRE

    Larson, Trina

    2012-01-01

    Following the mid-nineteenth century, every state in the expanding US founded at least one public insane asylum. Responding to the needs of those with severe cognitive and mental impairments who were poorly housed in prisons and private homes, the asylum promised enlightened management of a seemingly growing social problem. Professional discourse centered both on patients' needs for isolated and restful care and on the threat they posed to the larger community. While asylum superintendents de...

  1. 33 CFR 100.917 - The Old Club Cannonade, Harsens Island, MI.

    Science.gov (United States)

    2010-07-01

    ... Island, MI. 100.917 Section 100.917 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND..., Harsens Island, MI. (a) Regulated Area. A regulated area is established to include all waters of Lake St... creating a triangle shaped safety zone. (NAD 83). This area is near the southern end of Harsens Island...

  2. [Psychiatric family care in the Tapiau/East Prussia Asylum (1907-1940)].

    Science.gov (United States)

    Schmidt-Michel, P O

    1992-03-01

    At the end of the so-called "Weimar Republic" in German between the two world wars, and during the time of the Nazi regime, the psychiatric hospital and asylum in Tapiau near Königsberg/Kaliningrad had the highest incidence of psychiatric patients being looked after on an out-patient basis by host families. Data on this type of psychiatric care by external families were repeatedly published in detail between 1930 and 1937 by Karl Knapp, a psychiatrist who was actively engaged there for many years. After sterilisation of mentally diseased patients had been legally enforced and finances were restricted, family care stagnated, promoting instead a type of family care that was independent of psychiatric hospitals and was carried out on a "district" basis. After 1940, when in the course of enforcement of euthanasia almost all the inmates of psychiatric hospitals and asylums in East Prussia were murdered, the traces of patients entrusted to host family care faded out. PMID:1603867

  3. Making Sense of Pain: Delusions, Syphilis, and Somatic Pain in London County Council Asylums, c. 1900

    Directory of Open Access Journals (Sweden)

    Louise Hide

    2012-12-01

    Full Text Available During the late nineteenth century, a high percentage of male deaths in asylums was attributed to various forms of tertiary syphilis, most notably General Paralysis of the Insane (GPI and tabes dorsalis. It was not unusual for patients to present symptoms of both conditions, the latter of which could be agonizingly painful. Some patients also suffered from persecutory delusions, believing that electricity was running through them or that their limbs were gnawed by lions and wolves at night. Drawing on a theory advanced by a number of key alienists and pathologists of the period, I suggest that these delusions were misinterpretations of felt sensations and, as such, illusions rather than delusions. Despite the well-known problems around using these historical sources, I contend that recorded delusions in asylum case notes can be treated as narratives of pain that provide invaluable insights into patients' subjective experiences.

  4. EMDR versus Stabilization in traumatized Asylum Seekers and Refugees: Results of a pilot-study

    OpenAIRE

    Heide, ter, H.; Mooren, T.M.; Kleyn, W.; de, Jongh, Petra; Kleber, R.J.

    2011-01-01

    Background: Traumatised asylum seekers and refugees are clinically considered a complex population. Discussion exists on whether with this population treatment guidelines for post-traumatic stress disorder (PTSD) should be followed and Trauma-Focused Cognitive-Behavioural Therapy (TF-CBT) or Eye Movement Desensitisation and Reprocessing (EMDR) should be applied, or whether a phased model starting with stabilisation is preferable. Some clinicians fear that trauma-focused interventions may lead...

  5. EMDR versus stabilisation in traumatised asylum seekers and refugees: results of a pilot study

    OpenAIRE

    ter Heide, F. Jackie June; Mooren, Trudy M.; Kleijn, Wim; de Jongh, Ad; Kleber, Rolf J.

    2011-01-01

    Background: Traumatised asylum seekers and refugees are clinically considered a complex population. Discussion exists on whether with this population treatment guidelines for post-traumatic stress disorder (PTSD) should be followed and Trauma-Focused Cognitive-Behavioural Therapy (TF-CBT) or Eye Movement Desensitisation and Reprocessing (EMDR) should be applied, or whether a phased model starting with stabilisation is preferable. Some clinicians fear that trauma-focused interventions may lead...

  6. Mental health of asylum seekers: a cross-sectional study of psychiatric disorders

    Directory of Open Access Journals (Sweden)

    Heeren Martina

    2012-08-01

    Full Text Available Abstract Background Asylum procedures are known to be protracted, stretching to over ten years in many host countries. International research shows high levels of distress for asylum seekers. Little is known about actual psychiatric morbidity in this population, especially during the first few years postmigration. Methods The mental health status of two groups of asylum seekers was assessed: Group 1 (n = 43 had arrived in Switzerland 2.9 (SD 1.1 months prior to assessment, while Group 2 (n = 43 had arrived 15.5 (SD 3.2 months prior to assessment. Psychiatric disorders were diagnosed using the Mini International Neuropsychiatric Interview (MINI. Symptom severity of posttraumatic stress disorder (Posttraumatic Diagnostic Scale, anxiety (Hopkins Symptom Checklist, depression (Hopkins Symptom Checklist, and pain (Verbal Rating Scale were assessed using self-report questionnaires. Postmigratory factors such as German language proficiency and social contacts were also assessed. Interviews were conducted with the assistance of trained interpreters. Results Four out of ten participants met diagnostic criteria for at least one DSM-IV disorder. Groups did not differ with respect to psychiatric morbidity or symptom levels. Major depression (31.4% and PTSD (23.3% were diagnosed most frequently. The number of experienced traumatic event types was highly correlated with psychiatric morbidity. Conclusions Psychiatric morbidity in asylum seekers in the first two years after arrival is high, with no indication of a decrease in mental distress over time. Traumatic experiences seem to play a major role in morbidity during this time. Considering the magnitude of clinically relevant distress, a short psychological screening upon arrival with a focus on traumatic experiences may be warranted.

  7. Complex posttraumatic stress disorder in traumatised asylum seekers: a pilot study

    Directory of Open Access Journals (Sweden)

    Madeleine Kissane

    2014-09-01

    Full Text Available Background and Objectives: Complex posttraumatic stress disorder (cPTSD, a construct associated with early onset and repeated interpersonal trauma, has not previously been assessed in asylum seekers who have experienced major human rights violations. The aim of this pilot study was to describe the cPTSD symptom profile in asylum seekers, and to compare this profile between three groups of people who have experienced: human trafficking, domestic violence and/or torture. Methods: Over a period of eight weeks, clinicians working at the Helen Bamber Foundation charity invited 48 patients currently receiving psychotherapy to take part in the study, of whom 30 (62.5% agreed. The structured interview for disorders of extreme stress (SIDES was used to assess cPTSD in 29 asylum seekers, as one patient withdrew during the interview. Results: Participants originated from 18 countries, 72.4% were female, the median age at trauma onset was 17 years and the duration of trauma was ten years. Eight (27.6% participants were found to have cPTSD, defined as having all six symptom clusters, and 15 (51.7% had five or more cPTSD symptom clusters. Age at trauma onset, duration of trauma, last trauma experience, gender and trauma type were not found to be associated with cPTSD presence. Conclusions: Extensive cPTSD symptoms were common in all participants, regardless of the nature of the trauma experienced. Future research is needed to enable generalisability of cPTSD symptom profile in asylum seekers.

  8. Representations of Refugees and Asylum Seekers in the Irish Print Media

    OpenAIRE

    Patterson, Maria

    2001-01-01

    This study examines media representation of asylum seekers and refugees in Ireland. The research is based on a detailed content analysis and discourse analysis of media coverage of the issues involved in immigration in five national newspapers over selected periods. The contention of this work is that much of new public opinion has originated from, and gradually gained strength through, the ideology of the Irish print media.

  9. Transcultural Spirituality: The coping mechanisms of Refugees and Asylum Seekers: A Grounded Theory Study

    OpenAIRE

    Murgatroyd, Tamaryn

    2013-01-01

    There is evidence in the literature to suggest that Spirituality and Culture are neglected in nursing care (Greenstreet, 1999, Fernando, 2004). This has been attributed to lack of understanding and knowledge of how to deliver appropriate spiritual and cultural care, possibly due to the ambiguity of the two concepts. Refugees and Asylum Seekers appear to be vulnerable to mental health problems due to the experiences that they have had, and the lack of social support that they receive in the...

  10. Health and Social Needs of Traumatized Refugees and Asylum Seekers: An Exploratory Study

    OpenAIRE

    Strijk, Patricia; van Meijel, Berno; Gamel, Claudia

    2011-01-01

    The purpose of this study was to describe the care needs of adult traumatized refugees and asylum seekers. DESIGN AND METHODS.  A mixed-methods design was used. A survey was conducted using the Camberwell Assessment of Need (CAN) among 30 patients. Semistructured in-depth interviews were subsequently conducted with eight of these patients. FINDINGS.  Key themes among refugees are loneliness and grief. Refugees are in severe psychological distress. They also encounter all kinds of practical pr...

  11. Safer UK: preventing sexual maltreatment of unaccompanied asylum seeking minors and improving services for them.

    OpenAIRE

    Lay, Margaret; Papadopoulos, Irena; Gebrehiwot, Alem

    2007-01-01

    This report looks at the experiences of sexual abuse of young unaccompanied Ethiopian, Somalian and Eritrean asylum seekers. Based on interviews with these young people and with key professionals it considers the risks of child sexual abuse occurring, the effectiveness of preventive approaches and therapeutic interventions, and issues surrounding cultural competence. It covers the relevant legislation, the culture in the countries of origin, how sexual abuse can happen, disclosure, preventio...

  12. Law, dignity & socio-economic rights: the case of asylum seekers in Europe

    OpenAIRE

    Thornton, Liam

    2014-01-01

    This paper explores the interplay of dignity, law and rights as regards the socio-economic rights of asylum seekers. It does so by posing some questions as regards the extent to which this concept of 'reception' is preferable to the issue of socio-economic rights. This paper is not going to discuss the (rather depressing) situation in different EU member states; rather, this paper considers whether systems and processes of international and European human rights law offer heighted ...

  13. When lives are put on hold: Lengthy asylum processes decrease employment among refugees.

    Science.gov (United States)

    Hainmueller, Jens; Hangartner, Dominik; Lawrence, Duncan

    2016-08-01

    European governments are struggling with the biggest refugee crisis since World War II, but there exists little evidence regarding how the management of the asylum process affects the subsequent integration of refugees in the host country. We provide new causal evidence about how one central policy parameter, the length of time that refugees wait in limbo for a decision on their asylum claim, affects their subsequent economic integration. Exploiting exogenous variation in wait times and registry panel data covering refugees who applied in Switzerland between 1994 and 2004, we find that one additional year of waiting reduces the subsequent employment rate by 4 to 5 percentage points, a 16 to 23% drop compared to the average rate. This deleterious effect is remarkably stable across different subgroups of refugees stratified by gender, origin, age at arrival, and assigned language region, a pattern consistent with the idea that waiting in limbo dampens refugee employment through psychological discouragement, rather than a skill atrophy mechanism. Overall, our results suggest that marginally reducing the asylum waiting period can help reduce public expenditures and unlock the economic potential of refugees by increasing employment among this vulnerable population. PMID:27493995

  14. When lives are put on hold: Lengthy asylum processes decrease employment among refugees

    Science.gov (United States)

    Hainmueller, Jens; Hangartner, Dominik; Lawrence, Duncan

    2016-01-01

    European governments are struggling with the biggest refugee crisis since World War II, but there exists little evidence regarding how the management of the asylum process affects the subsequent integration of refugees in the host country. We provide new causal evidence about how one central policy parameter, the length of time that refugees wait in limbo for a decision on their asylum claim, affects their subsequent economic integration. Exploiting exogenous variation in wait times and registry panel data covering refugees who applied in Switzerland between 1994 and 2004, we find that one additional year of waiting reduces the subsequent employment rate by 4 to 5 percentage points, a 16 to 23% drop compared to the average rate. This deleterious effect is remarkably stable across different subgroups of refugees stratified by gender, origin, age at arrival, and assigned language region, a pattern consistent with the idea that waiting in limbo dampens refugee employment through psychological discouragement, rather than a skill atrophy mechanism. Overall, our results suggest that marginally reducing the asylum waiting period can help reduce public expenditures and unlock the economic potential of refugees by increasing employment among this vulnerable population. PMID:27493995

  15. Between remembrance technology and the production of truth: memory and narrative in asylum politics

    Directory of Open Access Journals (Sweden)

    Elisa Mencacci

    2015-04-01

    Full Text Available In the institutional pathway for recognition of asylum right, the narrative becomes, according to current regulations, the element to be sieved in order to ascertain title to international protection. The aim of this essay is analyzing the various declensions assumed by the narrative in this institutional process. Weaving together clinical and ethnographic data, drawn from the main phases that foreigners have to pass through in this event, I would like to highlight how, in the asylum system, the narrative takes the value of a tool directed, first of all at checking the applicant’s past, and second at co-producing a subject fitting to the media and legal dominant imaginary features. In this specific context, the treatment of traumatic injuries, recognized as basis of interrupted narratives, emerges as issue played in its turn on a double register: as adherence to specific schemes of "therapeutic governance" and as further control of specific events, experienced by asylum seekers in the past.

  16. Tuberculosis screening and follow-up of asylum seekers in Norway: a cohort study

    Directory of Open Access Journals (Sweden)

    Garåsen Helge

    2009-05-01

    Full Text Available Abstract Background About 80% of new tuberculosis cases in Norway occur among immigrants from high incidence countries. On arrival to the country all asylum seekers are screened with Mantoux test and chest x-ray aimed to identify cases of active tuberculosis and, in the case of latent tuberculosis, to offer follow-up or prophylactic treatment. We assessed a national programme for screening, treatment and follow-up of tuberculosis infection and disease in a cohort of asylum seekers. Methods Asylum seekers ≥ 18 years who arrived at the National Reception Centre from January 2005 to June 2006, were included as the total cohort. Those with a Mantoux test ≥ 6 mm or positive x-ray findings were included in a study group for follow-up. Data were collected from public health authorities in the municipality to where the asylum seekers had moved, and from hospital based internists in case they had been referred to specialist care. Individual subjects included in the study group were matched with the Norwegian National Tuberculosis Register which receive reports of everybody diagnosed with active tuberculosis, or who had started treatment for latent tuberculosis. Results The total cohort included 4643 adult asylum seekers and 97.5% had a valid Mantoux test. At least one inclusion criterion was fulfilled by 2237 persons. By end 2007 municipal public health authorities had assessed 758 (34% of them. Altogether 328 persons had been seen by an internist. Of 314 individuals with positive x-rays, 194 (62% had seen an internist, while 86 of 568 with Mantoux ≥ 15, but negative x-rays (16% were also seen by an internist. By December 31st 2006, 23 patients were diagnosed with tuberculosis (prevalence 1028/100 000 and another 11 were treated for latent infection. Conclusion The coverage of screening was satisfactory, but fewer subjects than could have been expected from the national guidelines were followed up in the community and referred to an internist. To

  17. Suicide death and hospital-treated suicidal behaviour in asylum seekers in the Netherlands: a national registry-based study

    Directory of Open Access Journals (Sweden)

    van Oostrum Irene EA

    2011-06-01

    Full Text Available Abstract Background Several suicide and suicidal behaviour risk factors are highly prevalent in asylum seekers, but there is little insight into the suicide death rate and the suicidal behaviour incidence in this population. The main objective of this study is to assess the burden of suicide and hospital-treated non-fatal suicidal behaviour in asylum seekers in the Netherlands and to identify factors that could guide prevention. Methods We obtained data on cases of suicide and suicidal behaviour from all asylum seeker reception centres in the Netherlands (period 2002-2007, age 15+. The suicide death rates in this population and in subgroups by sex, age and region of origin were compared with the rate in the Dutch population; the rates of hospital-treated suicidal behaviour were compared with that in the population of The Hague using indirect age group standardization. Results The study included 35 suicide deaths and 290 cases of hospital-treated suicidal behaviour. The suicide death rate and the incidence of hospital-treated suicidal behaviour differed between subgroups by sex and region of origin. For male asylum seekers, the suicide death rate was higher than that of the Dutch population (N = 32; RR = 2.0, 95%CI 1.37-2.83. No difference was found between suicide mortality in female asylum seekers and in the female general population of the Netherlands (N = 3; RR = 0.73; 95%CI 0.15-2.07. The incidence of hospital-treated suicidal behaviour was high in comparison with the population of The Hague for males and females from Europe and the Middle East/South West Asia, and low for males and females from Africa. Health professionals knew about mental health problems prior to the suicidal behaviour for 80% of the hospital-treated suicidal behaviour cases in asylum seekers. Conclusions In this study the suicide death rate was higher in male asylum seekers than in males in the reference population. The incidence of hospital-treated suicidal behaviour

  18. Seroprevalence of Antibodies against Measles, Rubella and Varicella among Asylum Seekers Arriving in Lower Saxony, Germany, November 2014-October 2015.

    Science.gov (United States)

    Toikkanen, Salla E; Baillot, Armin; Dreesman, Johannes; Mertens, Elke

    2016-01-01

    The number of asylum seekers arriving in Germany has increased rapidly since 2014 and cases of vaccine-preventable diseases at reception centres were reported. Asylum seekers 12 years and older arriving in Lower Saxony were serologically screened for antibodies against measles, rubella and varicella between November 2014 and October 2015. We calculated the seroprevalence from the screening data by disease, country of origin and age group and compared them to literature-based herd immunity thresholds in order to identify immunisation gaps. In total, 23,647 specimens were included in our study. Although the vast majority of asylum seekers tested positive for antibodies against measles, rubella and varicella, the seroprevalences were not sufficient to ensure herd immunity. The seroprevalences varied substantially between countries of origin and increased with age. Immunisation of asylum seekers against measles, rubella and varicella is needed and the detailed information on seroprevalences among subgroups of asylum seekers can be used for targeted immunisations at reception centres. PMID:27376309

  19. Case notes, case histories, and the patient's experience of insanity at Gartnavel Royal Asylum, Glasgow, in the nineteenth century.

    Science.gov (United States)

    Andrews, J

    1998-08-01

    This article is concerned primarily with questions as to how and why case notes were produced and utilized, and how they may (or may not) be used by historians. More specifically, it discusses how the Glasgow Royal Asylum's case notes may be deployed to access patients' experiences of madness and confinement. The deficiencies and biases of the case record are also explored. So too is the relationship of case notes with other asylum based records, including reception order questionnaires, with a separate section on patient writings as part of the case history corpus. This leads into an analysis of how the Asylum's case notes became case histories and for what purposes. These subjects are related to changes and continuities in medical ideologies about insanity, social attitudes to the insane and the nature of medical practice in asylums. Some fundamental shifts in emphasis in the use of the case note and case history occurred in this period. These shifts were associated with an increased emphasis on organic interpretations of mental disease and on clinical approaches to insanity; with the medicalization of asylum records and the wider discourse on insanity, and with declining deference to the public at large in the presentation of cases. The survey concludes by analysing the changing place of patient testimony within the case record. PMID:11620430

  20. The developmental consequences for asylum-seeking children living with the prospect for five years or more of enforced return to their home country

    NARCIS (Netherlands)

    Kalverboer, M.E.; Zijlstra, A.E.; Knorth, E.J.

    2009-01-01

    This study examines the European legal framework and policy on children's rights and on the development and developmental risks of children from asylum-seeking families who have lived in asylum centres for over five years with the prospect of being forced to return to their home country. The legal p

  1. The Quality of the Childrearing Environment of Refugee or Asylum-Seeking Children and the Best Interests of the Child : Reliability and Validity of the BIC-Q

    NARCIS (Netherlands)

    Zijlstra, A. Elianne; Kalverboer, Margrite E.; Post, Wendy J.; Knorth, Erik J.; Ten Brummelaar, Mijntje D. C.

    2012-01-01

    The Best Interest of the Child Questionnaire (BIC-Q) has been designed as an instrument for screening the quality of the rearing situation of asylum-seeking or refugee children. It is intended to aid legal decisions in asylum procedures. The aim of this study was to determine the reliability and the

  2. High Prevalence of Infectious Diseases and Drug-Resistant Microorganisms in Asylum Seekers Admitted to Hospital; No Carbapenemase Producing Enterobacteriaceae until September 2015

    NARCIS (Netherlands)

    Ravensbergen, Sofanne J.; Lokate, Mariette; Cornish, Darren; Kloeze, Eveline; Ott, Alewijn; Friedrich, Alex W.; van Hest, Rob; Akkerman, Onno W.; Lange, de Wiel C.; van der Werf, Tjip S.; Bathoorn, Erik; Stienstra, Ymkje

    2016-01-01

    Introduction The current refugee crisis emphasizes the need for information on infectious diseases and resistant microorganisms in asylum seekers with possible consequences for public health and infection control. Methods We collected data from asylum seekers admitted to our university hospital or w

  3. Dianchi Lake

    OpenAIRE

    Gipouloux, François

    2012-01-01

    This photo is taken in Dianchi lake of Kunming city. After 1970, the industrial zones and farmland areas around Kunming evacuated waste water into Dianchi Lake, resulting in a significant growth of cyanobacteria and serious eutrophication in Dianchi Lake. Although the Kunming city government has been actively trying to solve the problem of pollution in Dianchi Lake, in order to significantly improve water quality, the lake is still at a pollution level far below the level of drinkable water.

  4. [Communication and mental health: a discursive analysis of posters of the National Anti-Asylum Campaign Movement in Brazil].

    Science.gov (United States)

    Espirito Santo, Wanda; Araujo, Inesita Soares de; Amarante, Paulo

    2016-01-26

    The article analyzes two posters that with the same slogan - "Asylums nevermore" - promote National Anti-Asylum Day. The analysis was based on principles of the symptomatology of social discourse, articulating analytical concepts and practices arising from the French School and the pragmatic dimension of discourse analysis. The results revealed affirmation strategies of the movement for the qualification and exacerbation of the issues of the enunciation and other enunciators, namely political actors of the anti-asylum movement and their allies. It also reveals the attempt to disqualify competitive discourse, especially that which discloses the serious problems of its institutional models, but also by juxtaposing the positive presence of the issuers and enunciators of the posters. PMID:27276046

  5. MiNube

    OpenAIRE

    Villanueva Hernández, Yarilo David

    2015-01-01

    [ES]MiNube es una solución de almacenamiento de datos online enfocada en la privacidad, seguridad y control del usuario final. A diferencia de otras plataformas de almacenamiento en la nube en el que se depende de agentes externos, MiNube cede el control de los datos al usuario, permitiéndole configurar su propio entorno y definiendo políticas de encriptación en las que el propio usuario es el único agente capaz de acceder a sus datos. MiNube se compone de tres partes: Un servidor web para s...

  6. Non-clinicians’ judgments about asylum seekers’ mental health: how do legal representatives of asylum seekers decide when to request medico-legal reports?

    Directory of Open Access Journals (Sweden)

    Lucy Wilson-Shaw

    2012-10-01

    Full Text Available Background : Procedures for determining refugee status across Europe are being speeded up, despite the high prevalence of mental health difficulties among asylum seekers. An assurance given is that ‘‘vulnerable applicants’’ will be identified and excluded from accelerated procedures. Although experts have recommended assessments to be undertaken by experienced clinicians, this is unlikely to happen for political and financial reasons. Understanding how non-clinically qualified personnel perform assessments of mental health issues is timely and crucial. Misrecognition of refugees due to the inappropriate use of accelerated procedures involves the risk of returning the very people who have the right to protection from further persecution. Objective : To examine the decision making of immigration lawyers, who are an example of a group of nonclinicians who decide when and whether to refer asylum-seekers for psychiatric assessment. Method : Semi-structured interviews were conducted with 12 legal representatives working with people seeking refugee or human rights protection in the United Kingdom. The resultant material was analysed using Framework Analysis. Results : Themes clustered around the legal case, the client, the representative and the systems, all with sub-themes. A mapping exercise integrated these themes to show how representatives brought together questions of (1 evidential reasons for a report, influenced by their legal, psychological and case law knowledge, and (2 perceived evidence of mental distress, influenced by professional and personal experiences and expectations. Conclusions : The legal representatives interviewed were well-informed and trained in psychological issues as well as clearly dedicated to their clients. This helped them to attempt quasi-diagnoses of common mental health problems. They nonetheless demonstrated stereotypical understanding of post-traumatic stress disorder and other possible diagnoses and the

  7. "What if No One Had Spoken out Against this Policy?" The Rise of Asylum Seeker and Refugeee Advocacy in Australia

    Directory of Open Access Journals (Sweden)

    Diane Gosden

    2006-02-01

    Full Text Available This paper examines the rise of an asylum seeker and refugee advocacy movement in Australia in recent years. It situates this phenomenon within Alberto Melucci's understanding of social movements as variable and diffuse forms of social action involved in challenging the logic of a system. Following this theoretical framework, it explores the empirical features of this particular collective action, as well as the struggle to redefine the nature of the relationship between citizens of a sovereign state and 'the other' in the personage of asylum seekers and refugees.

  8. Turning Asylum Seekers into ‘Dangerous Criminals’: Experiences of the Criminal Justice System of those Seeking Sanctuary

    OpenAIRE

    Monish Bhatia

    2015-01-01

    Since the events of 9/11 in the US in 2001 and, four years later, the 7/7 London bombings in the UK, warnings of terrorist attacks are high on the public agenda in many western countries. Politicians and tabloid press in the UK have continued to make direct and indirect connections between asylum seekers, terrorism and crime. This has increasingly resulted in harsh policy responses to restrict the movement of ‘third-world’ nationals, criminalisation of immigration and asylum policy, and makin...

  9. Adult Asylum Seekers from the Middle East Including Syria in Central Europe: What Are Their Health Care Problems?

    OpenAIRE

    Pfortmueller, Carmen Andrea; Schwetlick, Miriam; Mueller, Thomas; Lehmann, Beat; Exadaktylos, Aristomenis Konstantinos

    2016-01-01

    Background Forced displacement related to persecution and violent conflict has reached a new peak in recent years. The primary aim of this study is to provide an initial overview of the acute and chronic health care problems of asylum seekers from the Middle East, with special emphasis on asylum seekers from Syria. Methods Our retrospective data analysis comprised adult patients presenting to our emergency department between 01.11.2011 and 30.06.2014 with the official resident status of an “a...

  10. School and community-based interventions for refugee and asylum seeking children: a systematic review.

    Directory of Open Access Journals (Sweden)

    Rebecca A Tyrer

    Full Text Available Research for effective psychological interventions for refugee and asylum-seeking children has intensified. The need for interventions in environments more easily accessed by children and families is especially relevant for newly arrived populations. This paper reviews the literature on school and community-based interventions aimed at reducing psychological disorders in refugee and asylum-seeking children.Comprehensive searches were conducted in seven databases and further information was obtained through searching reference lists, grey literature, and contacting experts in the field. Studies were included if they reported on the efficacy of a school or community-based mental health intervention for refugee or asylum-seeking children. Two independent reviewers made the final study selection, extracted data, and reached consensus on study quality. Results were summarized descriptively. The marked heterogeneity of studies excluded conducting a meta-analysis but study effect-sizes were calculated where possible. Twenty one studies met inclusion criteria for the review reporting on interventions for approximately 1800 refugee children. Fourteen studies were carried out in high-income countries in either a school (n = 11 or community (n = 3 setting and seven studies were carried out in refugee camps. Interventions were either primarily focused on the verbal processing of past experiences (n = 9, or on an array of creative art techniques (n = 7 and others used a combination of these interventions (n = 5. While both intervention types reported significant changes in symptomatology, effect sizes ranged from 0.31 to 0.93 and could mainly be calculated for interventions focusing on the verbal processing of past experiences.Only a small number of studies fulfilled inclusion criteria and the majority of these were in the school setting. The findings suggest that interventions delivered within the school setting can be successful in

  11. Pro-asylum Advocacy in the EU: Challenging the State of Exception

    OpenAIRE

    Hintjens, Helen; Kumar, Rajiv; Pouri, Ahmed

    2011-01-01

    textabstractIntroduction. This chapter explores examples of how pro-asylum advocates challenge the harsh measures used to punish those who try to enter or reside in the EU illegally, taking examples from The Netherlands and the UK. We explore organized resistance to the ‘3-Ds’, which are so typical of EU-wide migration policies: destitution, detention and deportation. Together these are the backbone of policies of deterrence. Sections 2 and 3 explore how ‘global apartheid’ and the ‘state of e...

  12. Asylum, Refuge and Public Policy: Current Trends and Future Dilemmas in the UK

    OpenAIRE

    Schuster, L; Solomos, J.

    2001-01-01

    Britain is a signatory of the 1950 European Convention on Human Rightsand Fundamental Freedoms and the 1951 Convention Relating to the Status of Refugees. It is only in the last decade, however, with the passage of the 1993 Asylum and Immigration Appeal Act and the 1998 Human Rights Act, that these two Conventions have became part of British law. This paper begins by exploring the impact of the incorporation of the 1951 Convention and then moves on to look at the hopes that are now pinned on ...

  13. The Intersection of Statelessness and Refugee Protection in US Asylum Policy

    Directory of Open Access Journals (Sweden)

    Maryellen Fullerton

    2014-07-01

    Full Text Available More than ten million people are stateless today. In a world of nation states, they live on the margins without membership in any state, and, as a consequence, have few enforceable legal rights. Stateless individuals face gaps in protection and in many cases experience persecution that falls within the refugee paradigm. However, US asylum policy does not adequately address the myriad legal problems that confront the stateless, who have been largely invisible in the jurisprudence and academic literature. Two federal appellate court opinions shed new light on the intersection of statelessness and refugee law in the United States. In 2010, Haile v. Holder examined the asylum claim of a young man rendered stateless when the Ethiopian government issued a decree denationalizing ethnic Eritreans.  In a 2011 case, Stserba v. Holder, the court reviewed an asylum claim by a woman who became stateless when the Soviet Union collapsed, and the successor state of Estonia enacted citizenship legislation that included a language requirement. This article analyzes the opinions which suggest that state action depriving residents of citizenship on ethnic and other protected grounds warrants a presumption of persecution.  This article also identifies additional circumstances in which stateless individuals may have a well-founded fear of persecution that qualifies them for asylum in the United States.In addition, this article notes that although far too many stateless individuals face persecution, not all of them do. Stateless persons who do not fear persecution, however, are also vulnerable. The absence of state protection condemns them to a precarious existence and their inability to obtain passports or other travel documents often prevents their return to states where they formerly resided. The refusal of most states to admit noncitizens frequently keeps stateless persons in limbo. Stateless individuals stranded in the United States live under a supervisory

  14. A mixed-method study of expert psychological evidence submitted for a cohort of asylum seekers undergoing refugee status determination in Australia.

    Science.gov (United States)

    Tay, Kuowei; Frommer, Naomi; Hunter, Jill; Silove, Derrick; Pearson, Linda; San Roque, Mehera; Redman, Ronnit; Bryant, Richard A; Manicavasagar, Vijaya; Steel, Zachary

    2013-12-01

    The levels of exposure to conflict-related trauma and the high rates of mental health impairment amongst asylum seekers pose specific challenges for refugee decision makers who lack mental health training. We examined the use of psychological evidence amongst asylum decision makers in New South Wales, Australia, drawing on the archives of a representative cohort of 52 asylum seekers. A mixed-method approach was used to examine key mental health issues presented in psychological reports accompanying each asylum application, including key documents submitted for consideration of asylum at the primary and review levels. The findings indicated that the majority of decision makers at both levels did not refer to psychological evidence in their decision records. Those who did, particularly in the context of negative decisions, challenged the expert findings and rejected the value of such evidence. Asylum seekers exhibiting traumatic stress symptoms such as intrusive thoughts and avoidance, as well as memory impairment, experienced a lower acceptance rate than those who did not across the primary and review levels. The findings raise concern that trauma-affected asylum seekers may be consistently disadvantaged in the refugee decision-making process and underscore the need to improve the understanding and use of mental health evidence in the refugee decision-making setting. The study findings have been used to develop a set of guidelines to assist refugee decision makers, mental health professionals and legal advisers in improving the quality and use of psychological evidence within the refugee decision-making context. PMID:24331888

  15. Gender and offender status predicting treatment success in refugees and asylum seekers with PTSD

    Directory of Open Access Journals (Sweden)

    Håkon Stenmark

    2014-01-01

    Full Text Available Background: Current knowledge is limited regarding patient characteristics related to treatment outcome of posttraumatic stress disorders (PTSD in refugees and asylum seekers. Objective: Gender, torture status, offender status, level of anger, and level of depression were investigated for possible effects on the treatment outcome. Method: Patient characteristics were explored in 54 refugees and asylum seekers who had completed a treatment program for PTSD. Non-responders (10, those who had the same or higher levels of symptom severity after treatment, were compared with responders, those who had lower symptom severity after treatment (44. Symptom severity was measured by Clinician-Administered PTSD Scale. The non-responders and responders constituted the dichotomous, dependent variable. The independent variables were gender, torture status, offender status, level of anger, and level of depression. T-tests and Exact Unconditional Homogeneity/Independence Tests for 2X2 Tables were used to study the relationship to treatment outcome. Results: Being male and reporting to have been a violent offender were significantly more frequent characteristics among the non-responders compared to the responders. The levels of pretreatment anger, depression and torture status did not affect the treatment outcome. Conclusions: The study adds support to findings that females benefit more from treatment of PTSD than males and that violent offenders are difficult to treat within the standard treatment programs.

  16. Social factors ameliorate psychiatric disorders in community-based asylum seekers independent of visa status.

    Science.gov (United States)

    Hocking, Debbie C; Kennedy, Gerard A; Sundram, Suresh

    2015-12-15

    The impact of industrialised host nations' deterrent immigration policies on the mental health of forced migrants has not been well characterised. The present study investigated the impact of Australia's refugee determination process (RDP) on psychiatric morbidity in community-based asylum-seekers (AS) and refugees. Psychiatric morbidity was predicted to be greater in AS than refugees, and to persist or increase as a function of time in the RDP. The effect on mental health of demographic and socio-political factors such as health cover and work rights were also investigated. Psychiatric morbidity was measured prospectively on five mental health indices at baseline (T1, n=131) and an average of 15.7 months later (T2, n=56). Psychiatric morbidity in AS significantly decreased between time points such that it was no longer greater than that of refugees at T2. Caseness of PTSD and demoralisation reduced in AS who gained protection; however, those who maintained asylum-seeker status at T2 also had a significant reduction in PTS and depression symptom severity. Reduced PTS and demoralisation symptoms were associated with securing work rights and health cover. Living in the community with work rights and access to health cover significantly improves psychiatric symptoms in forced migrants irrespective of their protection status. PMID:26518226

  17. Sleeping patterns of Afghan unaccompanied asylum-seeking adolescents: a large observational study.

    Science.gov (United States)

    Bronstein, Israel; Montgomery, Paul

    2013-01-01

    Unaccompanied asylum-seeking children (UASC) have experienced multiple traumas and are a high-risk group for posttraumatic stress disorder (PTSD). The effects of trauma are known to be associated with sleep problems; indeed sleeping problems are core features of PTSD. However, there has been no systematic research examining the sleep of this high risk group of children. This study presents the first evidence on the sleeping patterns of Afghan UASC living in the UK. A total of 222 male Afghan children, aged 13-18, were interviewed using validated self-report questionnaires measuring sleeping patterns and PTSD. Overall, UASC patterns for bed time and rise time appear acculturated to the country of asylum. Mean UASC sleep onset latency scores were approximately 20 minutes greater compared with normative scores, which may be a reflection of UASC pre-migration and post-migration experiences. As expected, UASC who screened above the clinical cut-off for PTSD reported significantly greater sleep onset latency, increased nightmares, and less total sleep time compared to the non-PTSD group. The results may be of particular interest to clinicians given that, compared to screening for PTSD, screening for sleep problems may be a less culturally disputed form of initial assessment indicating distress in UASC. Similarly, the field of UASC and refugee child interventions is largely focused on trauma, yet sleep may provide a novel avenue for equally or more effective treatment. PMID:23457517

  18. Seeking asylum in Denmark: Refugee children's mental health and exposure to violence

    DEFF Research Database (Denmark)

    Montgomery, Edith; Foldspang, Anders

    2005-01-01

    Aims: The aim of this study was to compare profiles of present mental health and previous exposure to violence among refugee children from the Middle East, whose asylum seeking families either did or did not obtain permission to stay in Denmark. Methods: Shortly after arrival in Denmark, the pare...... exposure to violence and their present mental health. There seems to be good reason to systematically integrate evidence on the children of refugee families in the treatment of applications for permission to stay.......Aims: The aim of this study was to compare profiles of present mental health and previous exposure to violence among refugee children from the Middle East, whose asylum seeking families either did or did not obtain permission to stay in Denmark. Methods: Shortly after arrival in Denmark......, the parents of 311 Middle-Eastern children answered a structured interview on their children’s exposure to organized violence and their mental health. The families were followed-up as concerns receipt of a residence permit. Results: At arrival in Denmark, the children’s patterns of previous exposure...

  19. LIMNOLOGY, LAKE BASINS, LAKE WATERS

    Directory of Open Access Journals (Sweden)

    Petre GÂŞTESCU

    2009-06-01

    Full Text Available Limnology is a border discipline between geography, hydrology and biology, and is also closely connected with other sciences, from it borrows research methods. Physical limnology (the geography of lakes, studies lake biotopes, and biological limnology (the biology of lakes, studies lake biocoenoses. The father of limnology is the Swiss scientist F.A. Forel, the author of a three-volume entitled Le Leman: monographie limnologique (1892-1904, which focuses on the geology physics, chemistry and biology of lakes. He was also author of the first textbook of limnology, Handbuch der Seenkunde: allgemeine Limnologie,(1901. Since both the lake biotope and its biohydrocoenosis make up a single whole, the lake and lakes, respectively, represent the most typical systems in nature. They could be called limnosystems (lacustrine ecosystems, a microcosm in itself, as the American biologist St.A. Forbes put it (1887.

  20. The association between acculturation patterns and mental health symptoms among Eritrean and Sudanese asylum seekers in Israel.

    Science.gov (United States)

    Nakash, Ora; Nagar, Maayan; Shoshani, Anat; Lurie, Ido

    2015-07-01

    Past research has documented the role acculturation plays in the process of adjustment to new cultures among migrants. Yet little attention has been paid thus far to the role of acculturation in the context of forced migration. In this study we examined the association between acculturation patterns and mental health symptoms among a convenience sample of Eritrean and Sudanese asylum seekers (n = 118) who accessed health services at the Physicians for Human Rights Open-Clinic in Israel. Participants completed measures on sociodemographic information as well as detention history, mental health symptoms, exposure to traumatic events, and acculturation pattern, in their native language upon accessing services. Consistent with our predictions, findings showed that acculturation predicted depressive symptoms among asylum seekers beyond the effect of history of detention and reports of experiences of traumatic events. Assimilated compared with integrated asylum seekers reported higher depressive symptoms. Findings draw attention to the paradox of assimilation, and the mental health risks it poses among those wishing to integrate into the new culture at the expanse of their original culture. Asylum seekers may be particularly vulnerable to the risks of assimilation in the restrictive policies that characterize many industrial countries in recent years. PMID:25090150

  1. Monitoring for Equality? Asylum Seekers and Refugees' Retention and Achievement in English for Speakers of Other Languages (ESOL)

    Science.gov (United States)

    Phillimore, Jenny

    2011-01-01

    Interest in the integration of refugees has grown with the increase in numbers of asylum seekers dispersed across the UK. The ability to communicate effectively in English is seen as the key priority in facilitating integration, while a lack of English language is seen as one of the major barriers to refugee employment. Some 267 million British…

  2. Refugees and Asylum Seekers in the UK: The Challenges of Accessing Education and Employment. NIACE Briefing Sheet 91

    Science.gov (United States)

    National Institute of Adult Continuing Education, 2009

    2009-01-01

    This briefing paper endeavours to highlight the challenges facing refugees and asylum seekers in the United Kingdom in accessing education, training and employment. It does not claim to cover all the issues but is intended as a starting point for providers of adult learning and/or advice. It initially sets out the facts about definitions and…

  3. Local Conceptualisations of the Education of Asylum-Seeking and Refugee Students: From Hostile to Holistic Models

    Science.gov (United States)

    Pinson, Halleli; Arnot, Madeleine

    2010-01-01

    Sociological research on the presence and yet invisibility of asylum-seeking and refugee pupils in the educational system in the UK is noticeably absent. This article offers insights into the ways in which the presence and the needs of such pupils are conceptualised by local authorities and schools. It draws on the results of a survey of 58…

  4. Could the BIC-Q be a decision-support tool to predict the development of asylum-seeking children?

    NARCIS (Netherlands)

    Zijlstra, A. Elianne; Kalverboer, Margrite E.; Post, Wendy J.; Ten Brummelaar, Mijntje D. C.; Knorth, Erik J.

    2013-01-01

    The Best Interest of the Child Questionnaire (BIC-Q) is an instrument to measure the quality of the childrearing environment. We used a sample of asylum-seeking children (N = 79) in the Netherlands to determine the relationship between the quality of the childrearing environment and the child's inte

  5. LIMNOLOGY, LAKE BASINS, LAKE WATERS

    OpenAIRE

    Petre GÂŞTESCU

    2009-01-01

    Limnology is a border discipline between geography, hydrology and biology, and is also closely connected with other sciences, from it borrows research methods. Physical limnology (the geography of lakes), studies lake biotopes, and biological limnology (the biology of lakes), studies lake biocoenoses. The father of limnology is the Swiss scientist F.A. Forel, the author of a three-volume entitled Le Leman: monographie limnologique (1892-1904), which focuses on the geology physics, chemistry a...

  6. Mi Pueblo Food Center

    Directory of Open Access Journals (Sweden)

    Alexis A. Babb

    2016-04-01

    Full Text Available This case describes a current growth opportunity for Mi Pueblo Food Center, a Hispanic grocery chain with locations throughout the Bay Area, California. The CEO of Mi Pueblo is contemplating opening a new store location in East Palo Alto, CA, which has been without a local, full-service grocery store for over 20 years. Case objectives are for students to develop an understanding of how the grocery industry operates, the risks and opportunities associated with opening a new grocery store location, and the impact on social, environmental, and economic sustainability. The SWOT (Strengths, Weaknesses, Opportunities, Threats framework is used to analyze whether or not it is feasible for Mi Pueblo to open a new location in East Palo Alto. This case may be used with students in graduate and advanced undergraduate courses.

  7. Treasury Offset Program (TOP) MI

    Data.gov (United States)

    Social Security Administration — The TOP MI helps OPSOS coordinate TOP case processing in the regions. The MI also helped communicate our progress and findings to BFQM and ORDP, as well as the ACOSS.

  8. Electronic Services Monthly MI Report

    Data.gov (United States)

    Social Security Administration — This electronic services monthly MI report contains monthly MI data for most public facing online online applications such as iClaim, electronic access, Mobile wage...

  9. Protecting and assisting refugees and asylum-seekers in Malaysia : the role of the UNHCR, informal mechanisms, and the 'Humanitarian exception'

    OpenAIRE

    Lego, Jera Beah H.

    2012-01-01

    This paper problematizes Malaysia's apparently contradictory policies – harsh immigration rules applied to refugees and asylum seekers on the one hand, and the continued presence and functioning of the United Nations High Commissioner for Refugees (UNHCR) on the other hand. It asks how it has been possible to protect and assist refugees and asylum seekers in light of such policies and how such protection and assistance is implemented, justified, and maintained. Giorgio Agamben's concept of th...

  10. Seen But Not Heard?:Parallels and Dissonances in the Treatment of Rape Narratives across the Asylum and Criminal Justice Contexts

    OpenAIRE

    Cowan, Sharon; Baillot, Helen; Munro, Vanessa

    2009-01-01

    A significant proportion of women seeking refugee status in the United Kingdom will claim to have been raped in their country of origin. Even where this is not the sole basis of an asylum claim, it may be relevant to its determination. While criminal justice responses to rape have been the subject of extensive academic criticism and legislative reform, the processes of disclosure and credibility assessment in the asylum context have received little attention. This article explores possible pa...

  11. MiDAS

    DEFF Research Database (Denmark)

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads;

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properti...

  12. Lake George

    OpenAIRE

    Mafabi, P.

    2000-01-01

    Uganda ratified the Ramsar Convention in 1988, and designated Lake George a Ramsar site. Located astride the equator, the lake and associated wetlands support a wide variety of biological resources. The reasons for this are varied, ranging from the good climate to shallow stratified waters (average 2.4m) which allow for a thorough mixing of the different layers, and a high alkalinity and photosynthetic activity. The status of Lake George is varied with most of the wetlands fringing the Lak...

  13. Unaccompanied & Denied: Regional Legal Framework for Unaccompanied Minors Asylum Seekers (UMAS

    Directory of Open Access Journals (Sweden)

    Rohaida Nordin

    2015-12-01

    Full Text Available Unaccompanied minor asylum seekers are vulnerable and thus, provided special international law protections. However, in reality, they are being mistreated as illegal immigrants and on thereceiving end of ethnic violence, discrimination, restrictions in enjoyment of their rights duly recognised by international human rights law. This article identifies legislative, policy and supportmechanisms which encompass the minimum UMAS guardianship standards at international law and which are evidence-based from best practice models for the provision of guardians for UMASinternationally. It presents situation of UMAS in relation to human rights violations with emphasis on the legal framework and practices in Australia and five ASEAN State Members. This article also highlights the various stands taken by various countries providing better legal framework and practices regarding the terms for protection and enforcement of human rights for UMAS. Finally, this article provides recommendations for Australia and ASEAN Member States to adopt in order to realise the international human rights of UMAS with respect to guardianship.

  14. Representation of Refugees, Asylum-Seekers and Refugee Affairs In Hungarian Dailies

    Directory of Open Access Journals (Sweden)

    Lilla VICSEK

    2008-11-01

    Full Text Available How does the press in Hungary write about refugees, asylum-seekers and refugee affairs? We sought to answer this question. Articles appearing in 2005 and 2006 in two leading national Hungarian dailies were examined with quantitative content analysis. The results show that the articles analyzed often treat refugee affairs as an “official” political matter. The high proportion of legislation and political positions conveys the image that refugee affairs are a state or intergovernmental matter, an “official”, legal, political issue rather than for example a humanitarian question. Most of the articles published in both papers write about problems and conflicts in connection with refugee affairs. The negative media image has different significance for different topics. We argue that the question of refugee affairs is a topic where the image shown by the media is of great relevance: the media can be a more important source of information on this subject than personal contacts.

  15. Human lead exposure in a late 19th century mental asylum population

    International Nuclear Information System (INIS)

    Lead isotope ratios and lead (Pb) levels were analyzed in 33 individuals from a forgotten cemetery at the Colorado Mental Health Institute at Pueblo, Colorado dating to 1879-1899. Isotopic ratios from healing bone fractures, cortical bone, and tooth dentine provide information about sources of Pb exposures over a range of time that illuminates individual's life histories and migration patterns. Historical records and Pb production data from the 19th century were used to create a database for interpreting Pb exposures for these African, Hispanic and European Americans. The analysis of these individuals suggests that Pb exposure noticeably impacted the mental health of 5-10% of the asylum patients in this frontier population, a high number by standards today, and that differences exist in the three ancestral groups' exposure histories

  16. Human lead exposure in a late 19th century mental asylum population.

    Science.gov (United States)

    Bower, Nathan W; McCants, Sarah A; Custodio, Joseph M; Ketterer, Michael E; Getty, Stephen R; Hoffman, J Michael

    2007-01-01

    Lead isotope ratios and lead (Pb) levels were analyzed in 33 individuals from a forgotten cemetery at the Colorado Mental Health Institute at Pueblo, Colorado dating to 1879-1899. Isotopic ratios from healing bone fractures, cortical bone, and tooth dentine provide information about sources of Pb exposures over a range of time that illuminates individual's life histories and migration patterns. Historical records and Pb production data from the 19th century were used to create a database for interpreting Pb exposures for these African, Hispanic and European Americans. The analysis of these individuals suggests that Pb exposure noticeably impacted the mental health of 5-10% of the asylum patients in this frontier population, a high number by standards today, and that differences exist in the three ancestral groups' exposure histories. PMID:17126382

  17. Human lead exposure in a late 19th century mental asylum population

    Energy Technology Data Exchange (ETDEWEB)

    Bower, Nathan W. [Department of Chemistry, Colorado College, Colorado Springs, CO 80903-3294 (United States)]. E-mail: nbower@coloradocollege.edu; McCants, Sarah A. [Department of Chemistry, Colorado College, Colorado Springs, CO 80903-3294 (United States); Custodio, Joseph M. [Department of Chemistry, Colorado College, Colorado Springs, CO 80903-3294 (United States); Ketterer, Michael E. [Departments of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ 86011-5698 (United States); Getty, Stephen R. [Biological Sciences Curriculum Study, Colorado Springs, CO 80918 (United States); Hoffman, J. Michael [Department of Anthropology, Colorado College, Colorado Springs, CO 8090-3294 (United States)

    2007-01-01

    Lead isotope ratios and lead (Pb) levels were analyzed in 33 individuals from a forgotten cemetery at the Colorado Mental Health Institute at Pueblo, Colorado dating to 1879-1899. Isotopic ratios from healing bone fractures, cortical bone, and tooth dentine provide information about sources of Pb exposures over a range of time that illuminates individual's life histories and migration patterns. Historical records and Pb production data from the 19th century were used to create a database for interpreting Pb exposures for these African, Hispanic and European Americans. The analysis of these individuals suggests that Pb exposure noticeably impacted the mental health of 5-10% of the asylum patients in this frontier population, a high number by standards today, and that differences exist in the three ancestral groups' exposure histories.

  18. The City of Others: Photographs from the City of London Asylum Archive

    Directory of Open Access Journals (Sweden)

    Caroline Bressey

    2011-09-01

    Full Text Available This photographic essay presents images from the City of London Asylum archive as a example of how the visual can be used to expand our investigations of social histories of Victorian London, particularly the multi-cultural nature of the city. The essay argues that images are an essential part of the research process, but also discusses some of the disadvantages and ethical tensions encountered through the use of such portraits for historical recovery. Despite these caveats, the paper concludes that we have much to learn from the images that present images of the city that would otherwise be difficult, if not impossible, for twenty-first-century researchers to access.

  19. Adult Asylum Seekers from the Middle East Including Syria in Central Europe: What Are Their Health Care Problems?

    Directory of Open Access Journals (Sweden)

    Carmen Andrea Pfortmueller

    Full Text Available Forced displacement related to persecution and violent conflict has reached a new peak in recent years. The primary aim of this study is to provide an initial overview of the acute and chronic health care problems of asylum seekers from the Middle East, with special emphasis on asylum seekers from Syria.Our retrospective data analysis comprised adult patients presenting to our emergency department between 01.11.2011 and 30.06.2014 with the official resident status of an "asylum seeker" or "refugee" from the Middle East.In total, 880 patients were included in the study. Of these, 625 (71.0% were male and 255 (29.0% female. The median age was 34 (range 16-84. 222 (25.2% of our patients were from Syria. The most common reason for presentation was surgical (381, 43.3%, followed by medical (321, 36.5% and psychiatric (137, 15.6%. In patients with surgical presentations, trauma-related problems were most common (n = 196, 50.6%. Within the group of patients with medical presentation, acute infectious diseases were most common (n = 141, 43.9%, followed by neurological problems (n = 70, 21.8% and gastrointestinal problems (n = 47, 14.6%. There were no differences between Syrian and non-Syrian refugees concerning surgical or medical admissions. The most common chronic disorder of unclear significance was chronic gastrointestinal problems (n = 132, 15%, followed by chronic musculoskeletal problems (n = 108, 12.3% and chronic headaches (n = 78, 8.9%. Patients from Syria were significantly younger and more often suffered from a post-traumatic stress disorder than patients of other nationalities (p<0.0001, and p = 0.05, respectively.Overall a remarkable number of our very young group of patients suffered from psychiatric disorders and unspecified somatic symptoms. Asylum seekers should be carefully evaluated when presenting to a medical facility and physicians should be aware of the high incidence of unspecified somatic symptoms in this patient population

  20. miRTargetLink—miRNAs, Genes and Interaction Networks

    Science.gov (United States)

    Hamberg, Maarten; Backes, Christina; Fehlmann, Tobias; Hart, Martin; Meder, Benjamin; Meese, Eckart; Keller, Andreas

    2016-01-01

    Information on miRNA targeting genes is growing rapidly. For high-throughput experiments, but also for targeted analyses of few genes or miRNAs, easy analysis with concise representation of results facilitates the work of life scientists. We developed miRTargetLink, a tool for automating respective analysis procedures that are frequently applied. Input of the web-based solution is either a single gene or single miRNA, but also sets of genes or miRNAs, can be entered. Validated and predicted targets are extracted from databases and an interaction network is presented. Users can select whether predicted targets, experimentally validated targets with strong or weak evidence, or combinations of those are considered. Central genes or miRNAs are highlighted and users can navigate through the network interactively. To discover the most relevant biochemical processes influenced by the target network, gene set analysis and miRNA set analysis are integrated. As a showcase for miRTargetLink, we analyze targets of five cardiac miRNAs. miRTargetLink is freely available without restrictions at www.ccb.uni-saarland.de/mirtargetlink. PMID:27089332

  1. Mi-spillet

    DEFF Research Database (Denmark)

    Larsen, Lea Lund; Hejlesen, Stine

    2003-01-01

    MI-spillet er et undervisningsspil til folkeskolens mellemtrin og udskolingen. Spillet omformer Howard Gardners teori om de mange intelligenser til et praktisk og håndgribeligt værktøj til brug i folkeskolen. Spillet indeholder et undervisningsmateriale bestående af lærervejledning og kopimappe...... emnebaseret eller tværfagligt arbejde. Alt materialet ligger samlet på en cd-rom, hvorfra materialet printes. Skolen kan derfor ved køb af én cd-rom printe og producere et ubegrænset antal spil. Cd-rommen indeholder: 1. Lærervejledning 2. MI-spillet * Gulvpladerne * Spørgsmål til spillet * Bilag til...

  2. High mycobacterial diversity in recreational lakes.

    Science.gov (United States)

    Roguet, A; Therial, C; Saad, M; Boudahmane, L; Moulin, L; Lucas, F S

    2016-05-01

    Although nontuberculous mycobacteria (NTM) are natural inhabitants of freshwater ecosystems, few studies have focused on their distribution in these habitats. Thus, the knowledge about the abundance as well as the composition of NTM remains limited and patchy in these environments. In this context, a prospective study was performed to identify favourable habitats for mycobacteria in two recreational lakes. Mycobacterial density and diversity were measured using quantitative real-time PCR and the MiSeq Illumina platform. For both lakes, five compartments were investigated, i.e. water column, air-water interface, sediment, epilithon and epiphyton biofilms. Nontuberculous mycobacteria were detected in all compartments in large densities and displayed a remarkable diversity. NTM were dominated by fast-growing species. Lakes and compartments appeared to shape mycobacteria assemblage composition as well as their densities. In both lakes, some OTUs assigned to the species level were identified as related to known opportunistic pathogens. PMID:26873594

  3. Violence Against Women and Asylum Seeking: Global Problems and Local Practices Applied to Guatemalan Women Immigrating for Safety

    OpenAIRE

    Roselyn Costantino; Karen Smith Rotabi; Debra H. Rodman

    2012-01-01

    This paper, based on broader discussions surrounding gender violence and immigration in the U.S., provides critical information on the historical context of extreme violence against women and femicide plaguing Central American societies today. Drawing on experiences of precedent setting cases of Guatemalan women, the authors offer suggestions for culturally specific treatment of and support for women who seek asylum in the U.S. out of justified fear for their and their family members’ lives s...

  4. Acts of Citizenship as a Politics of Resistance? Reflections on realizing concrete rights within the Israeli asylum regime

    OpenAIRE

    Müller, T.R.

    2016-01-01

    This paper investigates how Eritrean refugees in Israel and civil society organisations who engage with refugee issues contest the exclusionary politics of asylum in Israel. It presents various acts of claims-making initiated by Eritrean refugees themselves or in response to hostility by others, as well as acts inaugurated by Israeli civil society organisations on behalf of or with refugee populations. Drawing on the concept of activist acts of citizenship developed by Engin Isin, the paper s...

  5. [Social history of open care of the mentally ill--from the municipal asylum to social psychiatric care].

    Science.gov (United States)

    Haselbeck, H

    1985-09-01

    Outpatient psychiatric care linked to a hospital or institution is as old as psychiatry defining itself as a science. During the time of the Liberal Movement in Germany and the various revolutions that took place in several European countries (including Austria and various German states) in 1848, people were full of ideas and sociorevolutionary projects. It was then that they became conscious of the need to meet mentally ill persons in their own environment in order to help them in an adequate manner. Griesinger described in great detail such work as envisaged by him for his projected "municipal asylum" or "city asylum". However, all efforts in this direction were quashed in 1868 by a majority decision on the part of psychiatrics in favour of large-scale lunatic asyluma located far away from the densely populated areas. At the turn of the century, social awareness again began to grow; the asylums were overcrowded; and costs had risen tremendously. This resulted in building up a non-institutionalised "open service and care" for the insane. On the one hand, it was an outpatient care system in close co-operation with the asylum, i.e. the patients were looked up in their homes (Erlangen Model), whereas in several big cities the community Public Health Office was responsible for such psychiatric care (Gelsenkirchen Model). In the German Republic that existed from 1919 to 1933, "open" psychiatric care was extended, and the psychiatrist who advocated it were gradually drawn into a maelstrom of a sociodarwinistic type of racialism.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3903811

  6. Refugee education in countries of first asylum: Breaking open the black box of pre-resettlement experiences

    OpenAIRE

    Dryden-Peterson, Sarah Elizabeth

    2015-01-01

    The number of refugees who have fled across international borders due to conflict and persecution is at the highest level in recorded history. The vast majority of these refugees find exile in low-income countries neighboring their countries of origin. The refugee children who are resettled to North America, Europe, and Australia arrive with previous educational experiences in these countries of first asylum. This article examines these pre-resettlement educational experiences of refugee chil...

  7. 'Hearing the Right Gaps':Enabling and Responding to Disclosures of Sexual Violence within the UK Asylum Process

    OpenAIRE

    Cowan, Sharon; Baillot, Helen; Munro, Vanessa

    2013-01-01

    The barriers that prevent or delay female victims of sexual assault from disclosing to criminal justice authorities, and the obstacles that often disincline professional and lay decision-makers from finding such narratives credible have been well documented. This article explores the extent to which such difficulties may be replicated, and compounded, in the case of female asylum-seekers; it will examine the complex ways in which the structure and processes, as well as the heavily politicized...

  8. ‘Hearing the Right Gaps’:Enabling and Responding to Disclosures of Sexual Violence within the UK Asylum Process

    OpenAIRE

    Cowan, Sharon; Baillot, Helen; Munro, Vanessa

    2012-01-01

    The barriers that prevent or delay female victims of sexual assault from disclosing to criminal justice authorities, and the obstacles that often disincline professional and lay decision-makers from finding such narratives credible, have been well documented. This article explores the extent to which such difficulties may be replicated, and compounded, in the case of female asylum-seekers; it will examine the complex ways in which the structure and processes, as well as the heavily politicise...

  9. Unaccompanied Asylum-Seeking Refugee Children’s Forced Repatriation: Social Workers’ and Police Officers’ Health and Job Characteristics

    OpenAIRE

    Sundqvist, Johanna; Hansson, Jonas; Ghazinour, Mehdi; Ögren, Kenneth; Padyab, Mojgan

    2015-01-01

    During the past ten years the number of unaccompanied asylum-seeking refugee children has dramatically increased in Sweden. Some of them are permitted to stay in the receiving country, but some are forced back to their country of origin. Social workers and police officers are involved in these forced repatriations, and such complex situations may cause stressful working conditions. This study aimed to bridge the gap in knowledge of the relationship between general mental health and working wi...

  10. Measuring the health impact of human rights violations related to Australian asylum policies and practices: A mixed methods study

    OpenAIRE

    Mulholland Kim; Allotey Pascale; Johnston Vanessa; Markovic Milica

    2009-01-01

    Abstract Background Human rights violations have adverse consequences for health. However, to date, there remains little empirical evidence documenting this association, beyond the obvious physical and psychological effects of torture. The primary aim of this study was to investigate whether Australian asylum policies and practices, which arguably violate human rights, are associated with adverse health outcomes. Methods We designed a mixed methods study to address the study aim. A cross-sect...

  11. Responses to language barriers in consultations with refugees and asylum seekers: a telephone survey of Irish general practitioners.

    LENUS (Irish Health Repository)

    MacFarlane, Anne

    2008-01-01

    BACKGROUND: Refugees and asylum seekers experience language barriers in general practice. Qualitative studies have found that responses to language barriers in general practice are ad hoc with use of both professional interpreters and informal interpreters (patients\\' relatives or friends). However, the scale of the issues involved is unknown. This study quantifies the need for language assistance in general practice consultations and examines the experience of, and satisfaction with, methods of language assistance utilized. METHODS: Data were collected by telephone survey with general practitioners in a regional health authority in Ireland between July-August 2004. Each respondent was asked a series of questions about consulting with refugees and asylum seekers, the need for language assistance and the kind of language assistance used. RESULTS: There was a 70% (n = 56\\/80) response rate to the telephone survey. The majority of respondents (77%) said that they had experienced consultations with refugees and asylum seekers in which language assistance was required. Despite this, general practitioners in the majority of cases managed without an interpreter or used informal methods of interpretation. In fact, when given a choice general practitioners would more often choose informal over professional methods of interpretation despite the fact that confidentiality was a significant concern. CONCLUSION: The need for language assistance in consultations with refugees and asylum seekers in Irish general practice is high. General practitioners rely on informal responses. It is necessary to improve knowledge about the organisational contexts that shape general practitioners responses. We also recommend dialogue between general practitioners, patients and interpreters about the relative merits of informal and professional methods of interpretation so that general practitioners\\' choices are responsive to the needs of patients with limited English.

  12. Turning Asylum Seekers into ‘Dangerous Criminals’: Experiences of the Criminal Justice System of those Seeking Sanctuary

    Directory of Open Access Journals (Sweden)

    Monish Bhatia

    2015-10-01

    Full Text Available Since the events of 9/11 in the US in 2001 and, four years later, the 7/7 London bombings in the UK, warnings of terrorist attacks are high on the public agenda in many western countries. Politicians and tabloid press in the UK have continued to make direct and indirect connections between asylum seekers, terrorism and crime. This has increasingly resulted in harsh policy responses to restrict the movement of ‘third-world’ nationals, criminalisation of immigration and asylum policy, and making the violation of immigration laws punishable through criminal courts. This paper largely highlights the narratives of five asylum seekers who committed ‘crime’ by breaching immigration laws and were consequently treated as ‘dangerous criminals’ by the state authorities. More importantly it shows how these individuals experienced this treatment. The aim of this paper is to give voice to the victims of state abuse, claim space for victim agency, gather victim testimonies, challenge official explanations and in the process confront criminal and racist state practices.

  13. The psychiatric profession and the Australian government: the debate over collective depression syndrome among asylum-seeking detainees

    Directory of Open Access Journals (Sweden)

    William W Bostock

    2009-11-01

    Full Text Available William W BostockSchool of Government, University of Tasmania, Hobart, Tasmania, AustraliaAbstract: Psychiatrists have long had involvement with the political process, both individually and as a profession. They have made valuable contributions to debate over such issues as war, conflict, terrorism, torture, human rights abuse, drug abuse, suicide and other public health issues. However, they have also been complicit in some gross atrocities. Over several years there has been debate over the Australian Government’s treatment of asylum seekers, and the Royal Australian and New Zealand College of Psychiatrists took the unusual step of publicly criticizing the Australian Government’s policy on grounds of its toxicity leading to a diagnosis of collective depression syndrome, particularly among child detainees, but also adult detainees. The official Ministerial response was to deny that collective depression exists and to assert that the concept is meaningless. Can this intervention by psychiatrists be interpreted as a product of earlier political behaviors by psychiatrists? The willingness of psychiatrists to cooperate with other professions, notably psychologists, pediatricians, physicians and lawyers, is noted, as is presence of minority voices within the Australian psychiatric profession. The significance of the debate over the mental condition of asylum-seeking detainees is that its outcome has implications for how Australia sees itself and is seen by the rest of the world, that is, its national identity.Keywords: collective depression syndrome, psychiatric profession, political intervention, asylum seeker, Australian national identity

  14. Protection of human rights of asylum seekers and illegal migrants: Practice of European court of human rights

    Directory of Open Access Journals (Sweden)

    Đukanović Anđela

    2013-01-01

    Full Text Available The European Court of Human Rights plays an important role in protecting the rights of asylum seekers and illegal migrants through a set of different human rights. Requests for interim measures under Rule 39 of the Rules of Court have also great importance. In cases involving illegal migrants and asylum-seekers, the Court was often in a difficult position, given the contradictions that could arise from the protection of human rights and the legitimate aim of the Contracting States to control the entry, residence and expulsion of aliens. The recent Courts judgments in the case of M. S. S. against Belgium and in the case of Jama Hirsi and others v. Italy are particularly important because of their remarkable influence on the perception of the common asylum system in the EU. [Projekat Ministarstva nauke Republike Srbije, br. 179029: Srbija u savremenim međunarodnim odnosima: Strateški pravci razvoja i učvršćivanja položaja Srbije u međunarodnim integrativnim procesima - spoljnopolitički, međunarodni ekonomski, pravni i bezbednosni aspekti

  15. Unaccompanied Asylum-Seeking Refugee Children's Forced Repatriation: Social Workers' and Police Officers' Health and Job Characteristics.

    Science.gov (United States)

    Sundqvist, Johanna; Hansson, Jonas; Ghazinour, Mehdi; Ögren, Kenneth; Padyab, Mojgan

    2015-01-01

    During the past ten years the number of unaccompanied asylum-seeking refugee children has dramatically increased in Sweden. Some of them are permitted to stay in the receiving country, but some are forced back to their country of origin. Social workers and police officers are involved in these forced repatriations, and such complex situations may cause stressful working conditions. This study aimed to bridge the gap in knowledge of the relationship between general mental health and working with unaccompanied asylum-seeking refugee children who are due for forced repatriation. In addition, the role of psychosocial job characteristics in such relationships was investigated. A questionnaire including sociodemographic characteristics, the Swedish Demand-Control-Support Questionnaire, and the 12-item General Mental Health Questionnaire were distributed nationally. Univariate and multivariable regression models were used. Poorer mental health was associated with working with unaccompanied asylum-seeking refugee children among social workers but not among police officers. Psychological job demand was a significant predictor for general mental health among social workers, while psychological job demand, decision latitude, and marital status were predictors among police officers. Findings are discussed with special regard to the context of social work and police professions in Sweden. PMID:26153185

  16. Measurement of the direct <mi>CP> -violating parameter <mi>Ami><mi>CP> in the decay <mi>D>+<mi>Kmi>-<mimi>+<mi>π>+

    Energy Technology Data Exchange (ETDEWEB)

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Borysova, M.; Brandt, A.; Brandt, O.; Brock, R.; Bross, A.; Brown, D.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, V. N.; Fauré, A.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garbincius, P. H.; Garcia-Bellido, A.; García-González, J. A.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Gogota, O.; Golovanov, G.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J. -F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Holzbauer, J. L.; Howley, I.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jayasinghe, A.; Jeong, M. S.; Jesik, R.; Jiang, P.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kajfasz, E.; Karmanov, D.; Katsanos, I.; Kaur, M.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kumar, A.; Kupco, A.; Kurča, T.; Kuzmin, V. A.; Lammers, S.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; Lopes de Sa, R.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Madar, R.; Magaña-Villalba, R.; Malik, S.; Malyshev, V. L.; Mansour, J.; Martínez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; Miconi, F.; Mondal, N. K.; Mulhearn, M.; Nagy, E.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nguyen, H. T.; Nunnemann, T.; Orduna, J.; Osman, N.; Osta, J.; Pal, A.; Parashar, N.; Parihar, V.; Park, S. K.; Partridge, R.; Parua, N.; Patwa, A.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Pleier, M. -A.; Podstavkov, V. M.; Popov, A. V.; Prewitt, M.; Price, D.; Prokopenko, N.; Qian, J.; Quadt, A.; Quinn, B.; Ratoff, P. N.; Razumov, I.; Ripp-Baudot, I.; Rizatdinova, F.; Rominsky, M.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santos, A. S.; Savage, G.; Savitskyi, M.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schwanenberger, C.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shary, V.; Shaw, S.; Shchukin, A. A.; Simak, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Soustruznik, K.; Stark, J.; Stoyanova, D. A.; Strauss, M.; Suter, L.; Svoisky, P.; Titov, M.; Tokmenin, V. V.; Tsai, Y. -T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Verkheev, A. Y.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vilanova, D.; Vokac, P.; Wahl, H. D.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; Williams, M. R. J.; Wilson, G. W.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yamada, R.; Yang, S.; Yasuda, T.; Yatsunenko, Y. A.; Ye, W.; Ye, Z.; Yin, H.; Yip, K.; Youn, S. W.; Yu, J. M.; Zennamo, J.; Zhao, T. G.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zivkovic, L.

    2014-12-01

    We measure the direct mi>Cmi>mi>P>-violating parameter mi>Ami>mi>Cmi>mi>Pmi> for the decay of the charged charm meson, mi>Dmi>+mi>Kmi>-mi>πmi>+mi>πmi>+ (and charge conjugate), using the full 10.4 mi>fbmi>-1 sample of mi>p>mi>p>¯ collisions at mi>smi>=1.96 mi>TeVmi> collected by the D0 detector at the Fermilab Tevatron collider. We extract the raw reconstructed charge asymmetry by fitting the invariant mass distributions for the sum and difference of charge-specific samples. This quantity is then corrected for detector-related asymmetries using data-driven methods and for possible physics asymmetries (from mi>B>mi>D

  17. Playa Lakes

    Data.gov (United States)

    Kansas Data Access and Support Center — This digital dataset provides information about the spatial distribution of soil units associated with playa lakes. Specific soil types have been designated by the...

  18. Consultations by Asylum Seekers: Recent Trends in the Emergency Department of a Swiss University Hospital

    Science.gov (United States)

    Srivastava, David; Exadaktylos, Aristomenis K.

    2016-01-01

    Background Large-scale war-related migration to Switzerland and other European countries is currently challenging European health systems. Little is known about recent patterns and trends in Emergency Department (ED) consultations by Asylum Seekers (AS). Methods A retrospective single-centre analysis was performed of the data from all adult patients with the official status of “Asylum Seeker” or “Refugee” who consulted the ED of Bern University Hospital, Switzerland, between June 2012 and June 2015. Patient characteristics and clinical information, such as triage category, type of referral and discharge, violence-related injury and diagnostic group on discharge, were extracted from the computerised database or determined from the medical reports. Changes in categorical variables between the three studied years were described. Results A total of 1,653 eligible adult patients were identified in the 3-year period. Between the first (06/12–06/13) and third periods (06/14–06/15), the number of presentations per year increased by about 45%. The AS came from 62 different nations, the most common countries being Eritrea (13%), Somalia (13%) and Syria (11%). The mean age was 33.3 years (SD 12.3) and two thirds (65.7%) were male. The proportion of women increased over time. Moreover the relative proportions shifted from patients between 20 and 50 years to patients of under 20 or over 60 years. Nearly two thirds of the patients were walk-in emergencies and this proportion increased over time. The mean triage score was 2.9 (SD 0.7), with more than 90% presenting as “urgent consultation”. About half of the patients were treated for trauma (17.2%), infections (16.8%) or psychiatric problems (14.2%). Trauma was seen in a higher proportion of male than female patients. About 25% of the patients were admitted for in-hospital treatment. Conclusions The recent rise in AS in the population has lead to an increase in AS presenting to EDs. This changes the composition of

  19. Lake Ponkapog

    Institute of Scientific and Technical Information of China (English)

    蓝洋

    2002-01-01

    @@ Thirty years ago,Lake Ponkapog in Hartwell,New Jersey,was full of life.Many birds and animals rived beside the water,which was frill of fish.Now there are few birds.animals and fish.The lake water is polluted(污染的).It is in a colour of dirty brown,and it is filled with strange plants.

  20. Fleeing the Drug War Next Door: Drug-related Violence as a Basis for Refugee Protection for Mexican Asylum-Seekers

    Directory of Open Access Journals (Sweden)

    Holly Buchanan

    2011-02-01

    Full Text Available The death toll in Mexico due to drug-related violence has continued to rise since President Felipe Calderón initiated the Mexican Government's crackdown on drug trafficking organizations in 2006. Pervasive corruption among state and local government officials and alleged human rights violations by the Mexican military have added to the gravity of the endemic drug-related violence in Mexico. In response to the continuous violence in Mexico perpetrated by drug trafficking organiza- tions, a substantial number of Mexican citizens have fled to the United States seeking asylum. Due to the strict requirements for refugee status under international law and asylum protection under U.S. law, individuals seeking protection based on drug-related violence face several legal obstacles. This Article addresses the extent to which drug-related violence may con- stitute a basis for refugee status protection under international refugee law and U.S. asylum law. It seeks to provide insight into the potential viability of claims for refugee status brought by Mexican asylum-seekers fleeing drug-related violence. This Article concludes with a discussion on complementary protection under the Convention Against Torture and Other Cruel, Inhuman or Degrading Treatment or Punishment for Mexican asylum-seekers.

  1. Fleeing the Drug War Next Door: Drug-related Violence as a Basis for Refugee Protection for Mexican Asylum-Seekers

    Directory of Open Access Journals (Sweden)

    Holly Buchanan

    2011-02-01

    Full Text Available The death toll in Mexico due to drug-related violence has continued to rise since President Felipe Calderón initiated the Mexican Government's crackdown on drug trafficking organizations in 2006. Pervasive corruption among state and local government officials and alleged human rights violations by the Mexican military have added to the gravity of the endemic drug-related violence in Mexico. In response to the continuous violence in Mexico perpetrated by drug trafficking organiza- tions, a substantial number of Mexican citizens have fled to the United States seeking asylum. Due to the strict requirements for refugee status under international law and asylum protection under U.S. law, individuals seeking protection based on drug-related violence face several legal obstacles. This Article addresses the extent to which drug-related violence may con- stitute a basis for refugee status protection under international refugee law and U.S. asylum law. It seeks to provide insight into the potential viability of claims for refugee status brought by Mexican asylum-seekers fleeing drug-related violence. This Article concludes with a discussion on complementary protection under the Convention Against Torture and Other Cruel, Inhuman or Degrading Treatment or Punishment for Mexican asylum-seekers.  

  2. Access to Personal Data and the Right to Good Governance during Asylum Procedures after the CJEU’s YS and M. and S. judgment (C-141/12 and C-372/12)

    NARCIS (Netherlands)

    E. Brouwer; F. Zuiderveen Borgesius

    2015-01-01

    In the YS. and M. and S. judgment, the Court of Justice of the European Union ruled on three procedures in which Dutch judges asked for clarification on the right of asylum seekers to have access to the documents regarding the decision on asylum applications. The judgment is relevant for interpretin

  3. Lake Victoria: the Changing Lake.

    OpenAIRE

    Mwirigi, P.; Rutagemwa, D.; Gikuma-Njuru, P.; Njuguna, H.; Matovu, A.; Waya, R.; Mwebaza-Ndawula, L.; Ssenfuma-Nsubuga, M.; Kinobe, J.; Abuodha, J.; Hecky, R

    2005-01-01

    Water quality monitoring activities were carried out on physical-chemical parameters, water chemistry and biotic indices at selected littoral and pelagic stations along north-south and east-west transects over an annual cycle between 2000 and 2005. The activities were aimed at collecting baseline information and data for use to define the current lake conditions and make a water quality assessment of the lake in relation to nutrient/ pollutant loadings as a basis for future monitoring surveys...

  4. The politics of death in Mexico: dislocating human rights and asylum law through hybrid agents.

    Directory of Open Access Journals (Sweden)

    Ariadna Estévez

    2013-12-01

    Full Text Available In 2006 Mexico’s then-president Felipe Calderón declared war on drug trafficking. The human toll was devastating with the loss of over 95,000 lives and the forced disappearance of more than 27,000 people. In addition, two percent of the Mexican population was displaced with families forced to flee their homes in the face of criminal violence. This article offers an explanation of how death, forced disappearances, persecution and exile are in essence the specific effects of governmentalization of the Mexican state. This govern­mentalization includes the shared use, by criminals and authorities, of techniques for dominating the population and controlling the conduct of citizens through the practices of death, that is, by employing the politics of death (necropolitics. The article goes on to discuss how the objectives, rationality and governmentalization of the State serve to dislocate human rights discourse in such a way that its truth politics excludes people suffering serious human rights violations, such as Mexican asylum seekers. This is accompanied by a new mode of subjectivity produced by Mexico's politics of death – the Endriago subject – which operates as a hybrid perpetrator of human rights violations.

  5. The role of social support in the acculturation and mental health of unaccompanied minor asylum seekers.

    Science.gov (United States)

    Oppedal, Brit; Idsoe, Thormod

    2015-04-01

    There is a lack of knowledge about psychosocial resources that may sustain post-resettlement psychological adjustment among unaccompanied minor asylum-seekers. The aim of this study is to investigate the impact of social support from family abroad and friends on acculturation, discrimination, and mental health among these vulnerable children and youth. Questionnaire data were collected from a population-based multi-ethnic sample involving 895 unaccompanied minors resettled in municipalities in all regions of the country. They met in groups in their local communities. The informants were on average 18.6 years, and had an average length of stay in Norway of 3.5 years. The findings showed that the participants suffered from high levels of ongoing war related intrusive symptoms and depression. Still, at the same time they engaged in adaptation processes that are normative to youth with immigrant backgrounds, in terms of constructing supportive networks and developing culture competence. In accordance with the main effect hypothesis, social support had direct effects on depression and indirect effects by increasing culture competence that may aid the young refugees in dealing with discrimination. However, there were no effects of social support on symptoms of PTSD. The findings give direction to areas of interventions, beyond dealing with the sequel of the traumas the unaccompanied minors have been exposed to, not only for clinicians, but also social workers and school personnel. PMID:25614276

  6. Vicarious resilience and vicarious traumatisation: Experiences of working with refugees and asylum seekers in South Australia.

    Science.gov (United States)

    Puvimanasinghe, Teresa; Denson, Linley A; Augoustinos, Martha; Somasundaram, Daya

    2015-12-01

    The negative psychological impacts of working with traumatised people are well documented and include vicarious traumatisation (VT): the cumulative effect of identifying with clients' trauma stories that negatively impacts on service providers' memory, emotions, thoughts, and worldviews. More recently, the concept of vicarious resilience (VR) has been also identified: the strength, growth, and empowerment experienced by trauma workers as a consequence of their work. VR includes service providers' awareness and appreciation of their clients' capacity to grow, maintaining hope for change, as well as learning from and reassessing personal problems in the light of clients' stories of perseverance, strength, and growth. This study aimed at exploring the experiences of mental health, physical healthcare, and settlement workers caring for refugees and asylum seekers in South Australia. Using a qualitative method (data-based thematic analysis) to collect and analyse 26 semi-structured face-to-face interviews, we identified four prominent and recurring themes emanating from the data: VT, VR, work satisfaction, and cultural flexibility. These findings-among the first to describe both VT and VR in Australians working with refugee people-have important implications for policy, service quality, service providers' wellbeing, and refugee clients' lives. PMID:25795221

  7. Toward a European Immigration Policy and a Common Sets of Rules on Asylum

    Directory of Open Access Journals (Sweden)

    Rinaldo Bontempi

    2001-05-01

    Full Text Available This article deals with two Reports on immigration and asylum presented by the Commission in late November of 2000, which represented an important step in the evolution of the functions of the Government of the European Union in relation to issues previously dealt with within the context of the rules of national sovereignty.The Commission here proposes a “comprehensive” policy dealing with all (economic, social, political and humanitarian aspects related to the phenomenon of migration and, as a result, brings to the fore the need for effective coordination between the work of governments on the one hand, and that of social agents, associations, local andregional authorities on the other. According to the Commission, the principal elements of this new comprehensive approach are the following five policies: new channels for legal immigration; combatting illegal immigration; long-term immigration policies;cooperation with countries of origin; admission for humanitarian reasons. Of course, all this is but the beginning of a political process that is complex, difficult and sure to bring out the contradictions between the universalist callings of our democracies and the pressure from some sectors for simple control. Still, the course that has been set is the right one and merits a commitment to follow.

  8. [The emergence of the Québec asylum in the 19th century.].

    Science.gov (United States)

    Paradis, A

    1977-01-01

    This team of five philosophers analyses the 18th and 19th century Quebec discourse on the subject of insanity. The 18th century saw the insane excluded from social contact with the state recognizing only their indigence. They were relegated either to the "Loges", designed to expiate their sins since insanity was linked to an abuse of mind and body, or to prison for appropriate punishment, since madness was considered to lead to crime. But economic pressures produced by the growing number in indigents, including the mentally ill, led to the creation of the Beauport asylum in 1845. The authors then describe how the urban insane, marginal to both the French Canadian and English Canadian communities* were placed in private institutions and subjected to a system of profit maximization controlled by bourgeois physicians. This situation increased the distance between proprietors and occupants, and accounts for the lack of original discourse on the subject of insanity. In addition, the reasoning of the alienist physicians was without scientific foundation, taking root rather in the dominant industrial capitalist ideology. As for the content of the discourse, the Beauport physicians borrowed from moral treatment and restraint system notions, giving them a certain Quebec character. PMID:17093651

  9. Expression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle

    Directory of Open Access Journals (Sweden)

    Uney James B

    2011-06-01

    Full Text Available Abstract Background MicroRNAs (miRNAs are small RNA molecules that post-transcriptionally regulate gene expression and have been shown to play an important role during development. miR-1, miR-133a, miR-133b and miR-206 are expressed in muscle tissue and induced during muscle cell differentiation, a process that directs myoblasts to differentiate into mature myotubes, which are organized into myofibers. Although miR-1, miR-133a, miR-133b and miR-206 are well-studied in muscle, there is no information about their expression and function during human development. The purpose of this study was to determine the profile of these miRNAs in muscle cells isolated from different stages of human development. Results We examined the levels of miR-1, miR-133a, miR-133b and miR-206 during the development of human foetus. All four miRNA levels were found increased during late stages of human foetal muscle development. Increases in the expression levels of these miRNAs were proportional to the capacity of myoblasts to form myotubes. Changes in miRNA levels during human foetal development were accompanied by endogenous alterations in their known targets and also in their inducer, MyoD. Ectopic MyoD expression caused an induction of muscle cell differentiation in vitro, accompanied by an increase in the levels of miR-1, miR-133a, miR-133b and miR-206. Conclusions This study provides data about the profile of four miRNAs in human muscle cells isolated during different stages of foetal development. These results may shed light on the differentiation of muscle cells and regulation of muscle formation through miRNAs, during the development of human foetus.

  10. Medical care of asylum seekers: a descriptive study of the appropriateness of nurse practitioners' care compared to traditional physician-based care in a gatekeeping system

    Directory of Open Access Journals (Sweden)

    Pécoud Alain

    2007-10-01

    Full Text Available Abstract Background Medical care for asylum seekers is a complex and critical issue worldwide. It is influenced by social, political, and economic pressures, as well as premigration conditions, the process of migration, and postmigration conditions in the host country. Increasing needs and healthcare costs have led public health authorities to put nurse practitioners in charge of the management of a gatekeeping system for asylum seekers. The quality of this system has never been evaluated. We assessed the competencies of nurses and physicians in identifying the medical needs of asylum seekers and providing them with appropriate treatment that reflects good clinical practice. Methods This cross-sectional descriptive study evaluated the appropriateness of care provided to asylum seekers by trained nurse practitioners in nursing healthcare centers and by physicians in private practices, an academic medical outpatient clinic, and the emergency unit of the university hospital in Lausanne, Switzerland. From 1687 asylum seeking patients who had consulted each setting between June and December 2003, 450 were randomly selected to participate. A panel of experts reviewed their medical records and assessed the appropriateness of medical care received according to three parameters: 1 use of appropriate procedures to identify medical needs (medical history, clinical examination, complementary investigations, and referral, 2 provision of access to treatment meeting medical needs, and 3 absence of unnecessary medical procedures. Results In the nurse practitioner group, the procedures used to identify medical needs were less often appropriate (79% of reports vs. 92.4% of reports; p Conclusion Although the nursing gatekeeping system provides appropriate treatment to asylum seekers, it might be improved with further training in recording medical history and performing targeted clinical examination.

  11. Limited Resettlement and Ongoing Uncertainty: responses to and experiences of people seeking asylum in Australia and Indonesia

    Directory of Open Access Journals (Sweden)

    Caroline Fleay

    2016-07-01

    Full Text Available In the wake of the Coalition Government’s narrow victory in the first Australian election since the adoption of policies known as Operation Sovereign Borders, this special edition of Cosmopolitan Civil Societies focuses its attention on the treatment of refugees and asylum seekers1 . It explores some of the experiences of people both in Australia and Indonesia who are seeking a life of safety, as well as the responses of civil society groups and governments, following the commencement of policies that have vastly reduced the opportunities for refugee resettlement in Australia.

  12. Koontz Lake

    OpenAIRE

    Zebell, Dennis A; Medors, Sky K; Delgado, Dan G

    2013-01-01

    A case study of the SR 23 replacement at the Koontz Lake Dam will be presented. The dam replacement, road re-alignment, and labyrinth spillway will be discussed. The design criteria and processes associated with each of those items will be discussed as well as the coordination with and expectations of the multiple owners involved with the project.

  13. Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients

    Directory of Open Access Journals (Sweden)

    Qiu Shuwei

    2013-01-01

    Full Text Available Abstract Background Glioblastoma multiforme (GBM is the most common and aggressive brain tumor with poor clinical outcome. Identification and development of new markers could be beneficial for the diagnosis and prognosis of GBM patients. Deregulation of microRNAs (miRNAs or miRs is involved in GBM. Therefore, we attempted to identify and develop specific miRNAs as prognostic and predictive markers for GBM patient survival. Methods Expression profiles of miRNAs and genes and the corresponding clinical information of 480 GBM samples from The Cancer Genome Atlas (TCGA dataset were downloaded and interested miRNAs were identified. Patients’ overall survival (OS and progression-free survival (PFS associated with interested miRNAs and miRNA-interactions were performed by Kaplan-Meier survival analysis. The impacts of miRNA expressions and miRNA-interactions on survival were evaluated by Cox proportional hazard regression model. Biological processes and network of putative and validated targets of miRNAs were analyzed by bioinformatics. Results In this study, 6 interested miRNAs were identified. Survival analysis showed that high levels of miR-326/miR-130a and low levels of miR-323/miR-329/miR-155/miR-210 were significantly associated with long OS of GBM patients, and also showed that high miR-326/miR-130a and low miR-155/miR-210 were related with extended PFS. Moreover, miRNA-323 and miRNA-329 were found to be increased in patients with no-recurrence or long time to progression (TTP. More notably, our analysis revealed miRNA-interactions were more specific and accurate to discriminate and predict OS and PFS. This interaction stratified OS and PFS related with different miRNA levels more detailed, and could obtain longer span of mean survival in comparison to that of one single miRNA. Moreover, miR-326, miR-130a, miR-155, miR-210 and 4 miRNA-interactions were confirmed for the first time as independent predictors for survival by Cox regression model

  14. The recovering Dian Lake

    OpenAIRE

    Ai, Chi-Han

    2013-01-01

    Dian Lake, also known as Kunming Lake, is the largest freshwater lake in Yunnan Province. However, the value of tourism isn't a perpetual blessing for Dian Lake. Since 1980, due to the rapid urbanization in China, water pollution in Dian Lake has worsened year by year.

  15. Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer

    International Nuclear Information System (INIS)

    MicroRNAs (miRNAs) regulate gene expression by binding to mRNA, and can function as oncogenes or tumor suppressors depending on the target. In this study, using qRT-PCR, we examined the expression of six miRNAs (miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145) in tumors from 193 prospectively recruited patients with colorectal cancer, and associations with clinicopathological parameters and patient outcome were analyzed. The miRNAs were chosen based on previous studies for their biomarker potential and suggested biological relevance in colorectal cancer. The miRNA expression was examined by qRT-PCR. Associations between miRNA expression and clinicopathological variables were explored using Mann–Whitney U and Kruskal-Wallis test while survival was estimated using the Kaplan-Meier method and compared using the log-rank test. MiR-101 was hardly expressed in the tumor samples, while for the other miRNAs, variable expression levels and expression ranges were observed, with miR-21 being most abundantly expressed relative to the reference (RNU44). In our study cohort, major clinical significance was demonstrated only for miR-31, as high expression was associated with advanced tumor stage and poor differentiation. No significant associations were found between expression of the investigated miRNAs and metastasis-free or overall survival. Investigating the expression of six miRNAs previously identified as candidate biomarkers in colorectal cancer, few clinically relevant associations were detected in our patient cohort. Our results emphasize the importance of validating potential tumor markers in independent patient cohorts, and indicate that the role of miRNAs as colorectal cancer biomarkers is still undetermined

  16. The institutional response to mental disorder in Ireland: censuses of Irish asylums, psychiatric hospitals and units 1844-2014.

    Science.gov (United States)

    Walsh, D; Daly, A; Moran, R

    2016-08-01

    Before the eighteenth century, there was limited response to the problem of psychiatric illness in Ireland as in many other countries. The asylums of the 1820s and 1830s were no sooner opened than they were overcrowded. A second wave of asylum building commenced in the second half of the nineteenth century continuing up to the early twentieth century. In 1966, the Report of the Commission on Mental Illness noted that the rate of psychiatric beds in Ireland per 1,000 was one of the highest in the world. The report called for a change in the policy of caring for the mentally ill in psychiatric hospitals to more community-based settings and in psychiatric units located in general hospital settings, along with a call for more research into mental illness. The result of the latter was the establishment of the first census of psychiatric patients resident in psychiatric hospitals. Thus began fifty years of census reporting and the subsequent establishment of the National Psychiatric Inpatient Reporting System (NPIRS). PMID:26667467

  17. Factors associated with latent tuberculosis among asylum seekers in Switzerland: a cross-sectional study in Vaud County

    Directory of Open Access Journals (Sweden)

    Sarivalasis Apostolos

    2012-11-01

    Full Text Available Abstract Background Screening and treatment of latent tuberculosis infection (LTBI in asylum seekers (AS may prevent future cases of tuberculosis. As the screening with Interferon Gamma Release Assay (IGRA is costly, the objective of this study was to assess which factors were associated with LTBI and to define a score allowing the selection of AS with the highest risk of LTBI. Methods In across-sectional study, AS seekers recently arrived in Vaud County, after screening for tuberculosis at the border were offered screening for LTBI with T-SPOT.TB and questionnaire on potentially risk factors. The factors associated with LTBI were analyzed by univariate and multivariate regression. Results Among 393 adult AS, 98 (24.93% had a positive IGRA response, five of them with active tuberculosis previously undetected. Six factors associated with LTBI were identified in multivariate analysis: origin, travel conditions, marital status, cough, age and prior TB exposure. Their combination leads to a robust LTBI predictive score. Conclusions The prevalence of LTBI and active tuberculosis in AS is high. A predictive score integrating six factors could identify the asylum seekers with the highest risk for LTBI.

  18. Sexual Maltreatment of Unaccompanied Asylum-Seeking Minors from the Horn of Africa: A Mixed Method Study Focusing on Vulnerability and Prevention

    Science.gov (United States)

    Lay, Margaret; Papadopoulos, Irena

    2009-01-01

    Objectives: The study described in this paper sought to identify the social, cultural, and political factors that effect African unaccompanied asylum-seeking minors' (UASM) vulnerability to sexual maltreatment in England. It aimed to illuminate how child protection measures could be strengthened for this highly marginalized group. Methods: A mixed…

  19. A Lie More Disastrous than the Truth: Asylum and the identification of trafficked women in the UK

    Directory of Open Access Journals (Sweden)

    Abigail Stepnitz

    2012-09-01

    Full Text Available This article explores the impact that nationality can have on a person’s experience of being identified as a victim of trafficking in the UK. Responses to individuals and disparities in rates of recognition depending on nationality are cause for great concern. The rhetoric and the response to women who have experienced trafficking varies considerably depending upon the citizenship, residency and documentation status of the individual, particularly highlighting the differential treatment of trafficking cases of British women, European Union nationals, and third-country (non UK, non EU nationals, the majority of whom are also asylum seekers. This differential treatment is played out in multiple ways, many of which result in women’s inability to realise procedural and substantive rights. The article examines the use of official “identification” mechanisms that place women into the administrative category of “victim”, and the central role of the asylum system in all areas of UK anti-trafficking responses. This above all, to refuse to be a victim. Unless I can do that I can do nothing. I have to recant, give up the old belief that I am powerless... A lie which was always more disastrous than the truth would have been. The word games, the winning and losing games are finished; at the moment there are no others but they will have to be invented, withdrawing is no longer possible. — Margaret Atwood, Surfacing1 The response to human trafficking into and within the United Kingdom is a complicated and yet incomplete combination of strategies, interventions and rhetoric, focused predominantly on immigration control and crime reduction, with support to individuals and prevention of exploitation as convenient outputs but not drivers of policy or practice. The introduction of human rights-based approaches has only emerged over the last decade, with discussions about the rights and entitlements of the trafficked beginning in earnest only in the

  20. Global warming alters carbon sink and source situation of the Tibetan lakes

    Science.gov (United States)

    Jiang, H.; Ni, Q.; Yang, J.; Liu, W.

    2015-12-01

    Global warming would accelerate glacier retreat and permafrost degeneration on the Tibetan Plateau. The carbon stored in permafrost would be released to nearby lakes. However, little is known about how the carbon sink and source situation could be altered and what role the microbial community could play in Tibetan lakes in response to global warming. To fill this knowledge gap, six lakes (Erhai Lake, Qinghai Lake, Tuosu Lake, Gahai Lake, Xiaochaidan Lake and Lake Chaka) on the Tibetan Plateau were studied. In order to compare the seasonal variations in geochemistry and microbial communities, two sampling cruises were performed (May and July of 2015, corresponding to dry and wet seasons, respectively). For each lake, salinity, pH, dissolved organic carbon (DOC), total nitrogen (TN), and chlorophyll were measured for water samples, and salinity and total organic carbon (TOC) were measured for sediments. Chamber-based greenhouse gas flux measurement were performed on the surface of each lake. Microbial communities were analyzed by using MiSeq sequencing technique. The results showed that in response to seasonal variation (from dry to set season), lake surface increased by 5-20% (calculated on the basis of satellite data) and salinity decreased by 4-30% for the studied lakes, suggesting the studied lakes were diluted by precipitations. The DOC contents of the lake waters were almost stable for the studied lakes, whereas TN increased by more than 70% for the lakes with salinity less than 100g/L. In the meanwhile, chlorophyll content increased by more than 180% for lakes with low salinities (Erhai Lake, Qinghai Lake, and Tuosu Lake) and decreased by 17-94% for lakes with high salinities (Gahai Lake, Xiaoxhaidan Lake, and Lake Chaka. This indicated that desalination (precipitation plus glacier melt) would increase carbon fixation potential in Tibetan lakes. Microbial community analyses showed that microbial diversity increased in response to desalination. All in all

  1. miREE: miRNA recognition elements ensemble

    Directory of Open Access Journals (Sweden)

    Reyes-Herrera Paula H

    2011-11-01

    Full Text Available Abstract Background Computational methods for microRNA target prediction are a fundamental step to understand the miRNA role in gene regulation, a key process in molecular biology. In this paper we present miREE, a novel microRNA target prediction tool. miREE is an ensemble of two parts entailing complementary but integrated roles in the prediction. The Ab-Initio module leverages upon a genetic algorithmic approach to generate a set of candidate sites on the basis of their microRNA-mRNA duplex stability properties. Then, a Support Vector Machine (SVM learning module evaluates the impact of microRNA recognition elements on the target gene. As a result the prediction takes into account information regarding both miRNA-target structural stability and accessibility. Results The proposed method significantly improves the state-of-the-art prediction tools in terms of accuracy with a better balance between specificity and sensitivity, as demonstrated by the experiments conducted on several large datasets across different species. miREE achieves this result by tackling two of the main challenges of current prediction tools: (1 The reduced number of false positives for the Ab-Initio part thanks to the integration of a machine learning module (2 the specificity of the machine learning part, obtained through an innovative technique for rich and representative negative records generation. The validation was conducted on experimental datasets where the miRNA:mRNA interactions had been obtained through (1 direct validation where even the binding site is provided, or through (2 indirect validation, based on gene expression variations obtained from high-throughput experiments where the specific interaction is not validated in detail and consequently the specific binding site is not provided. Conclusions The coupling of two parts: a sensitive Ab-Initio module and a selective machine learning part capable of recognizing the false positives, leads to an improved

  2. Bathymetry of Lake Ontario

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Bathymetry of Lake Ontario has been compiled as a component of a NOAA project to rescue Great Lakes lake floor geological and geophysical data and make it more...

  3. Designated Wildlife Lakes - points

    Data.gov (United States)

    Minnesota Department of Natural Resources — This is a point shapefile of Designated Wildlife Lakes in Minnesota. This shapefile was created by converting lake polygons from the Designated Wildlife Lakes...

  4. Bathymetry of Lake Michigan

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Bathymetry of Lake Michigan has been compiled as a component of a NOAA project to rescue Great Lakes lake floor geological and geophysical data and make it more...

  5. Bathymetry of Lake Huron

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Bathymetry of Lake Huron has been compiled as a component of a NOAA project to rescue Great Lakes lake floor geological and geophysical data and make it more...

  6. Hydrography - Lakes Assessments - Attaining

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This layer shows only attaining lakes of the Integrated List. The Lakes Integrated List represents lake assessments in an integrated format for the Clean Water Act...

  7. Bathymetry of Lake Superior

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Bathymetry of Lake Superior has been compiled as a component of a NOAA project to rescue Great Lakes lake floor geological and geophysical data and make it more...

  8. Great Lakes Bathymetry

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Bathymetry of Lakes Michigan, Erie, Saint Clair, Ontario and Huron has been compiled as a component of a NOAA project to rescue Great Lakes lake floor geological...

  9. EMDR versus stabilisation in traumatised asylum seekers and refugees: results of a pilot study

    Directory of Open Access Journals (Sweden)

    Rolf J. Kleber

    2011-08-01

    Full Text Available Traumatised asylum seekers and refugees are clinically considered a complex population. Discussion exists on whether with this population treatment guidelines for post-traumatic stress disorder (PTSD should be followed and Trauma-Focused Cognitive-Behavioural Therapy (TF-CBT or Eye Movement Desensitisation and Reprocessing (EMDR should be applied, or whether a phased model starting with stabilisation is preferable. Some clinicians fear that trauma-focused interventions may lead to unmanageable distress or may be ineffective. While cognitive-behavioural interventions have been found to be effective with traumatised refugees, no studies concerning the efficacy of EMDR with this population have been conducted as yet.In preparation for a randomised trial comparing EMDR and stabilisation with traumatised refugees, a pilot study with 20 participants was conducted. The objective was to examine feasibility of participation in a randomised trial for this complex population and to examine acceptability and preliminary efficacy of EMDR.Participants were randomly allocated to 11 sessions of either EMDR or stabilisation. Symptoms of PTSD (SCID-I, HTQ, depression and anxiety (HSCL-25, and quality of life (WHOQOL-BREF were assessed at pre- and post-treatment and 3-month follow-up.Participation of traumatised refugees in the study was found feasible, although issues associated with complex traumatisation led to a high pre-treatment attrition and challenges in assessments. Acceptability of EMDR was found equal to that of stabilisation with a high drop-out for both conditions. No participants dropped out of the EMDR condition because of unmanageable distress. While improvement for EMDR participants was small, EMDR was found to be no less efficacious than stabilisation. Different symptom courses between the two conditions, with EMDR showing some improvement and stabilisation showing some deterioration between pre-treatment and post-treatment, justify the conduct

  10. The Tumor Cytosol miRNAs, Fluid miRNAs and Exosome miRNAs in Lung Cancer

    Directory of Open Access Journals (Sweden)

    Xin eQin

    2015-01-01

    Full Text Available The focus of this review is to provide an update on the progress of microRNAs (miRNAs as potential biomarkers for lung cancer. miRNAs are single-stranded, small noncoding RNAs that regulate gene expression and show tissue-specific signatures. Accumulating evidence indicates that miRNA expression patterns represent the in vivo status in physiology and disease. Moreover, miRNAs are stable in serum and other clinically convenient and available tissue sources, so they are being developed as biomarkers for cancer and other diseases. Cancer is currently the primary driver of the field, but miRNA biomarkers are being developed for many other diseases such as cardiovascular and central nervous system diseases. Here we examine the framework and scope of the miRNA landscape as it specifically relates to the translation of miRNA expression patterns/signatures into biomarkers for developing diagnostics for lung cancer. We focus on examining tumor cytosol miRNAs, fluid miRNAs, and exosome miRNAs in lung cancer, the connections among these miRNAs, and the potential of miRNA biomarkers for the development of diagnostics. In lung cancer, miRNAs have been studied in both cell populations and in the circulation. However, a major challenge is to develop biomarkers to monitor cancer development and to identify circulating miRNAs that are linked to cancer stage. Importantly, the fact that miRNAs can be successfully harvested from biological fluids allows for the development of biofluid biopsies, in which miRNAs as circulating biomarkers can be captured and analyzed ex vivo. Our hope is that these minimally invasive entities provide a window to the in vivo milieu of the patients without the need for costly, complex invasive procedures, rapidly moving miRNAs from research to the clinic.

  11. miRNA-Based Therapeutic Strategies

    OpenAIRE

    Ishida, Masaharu; Selaru, Florin M.

    2012-01-01

    Micro-RNAs (miRNAs) are short non-coding RNA species, thought to act primarily through downregulation of target mRNA species with subsequent decrease in encoded proteins. Recent studies revealed that miRNAs play pivotal roles in physiology and disease, and therapeutic targeting has started being investigated. Generally, the up-regulation of miRNAs is achieved through administration of synthetic miRNAs or administration of miRNA expressing vectors. The down-regulation of miRNAs is achieved thr...

  12. Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression

    Czech Academy of Sciences Publication Activity Database

    Aherne, S.T.; Madden, S.F.; Hughes, D. J.; Pardini, B.; Naccarati, A.; Levý, M.; Vodička, Pavel; Neary, P.; Dowling, P.; Clynes, M.

    2015-01-01

    Roč. 15, apr 30 (2015), s. 2-13. ISSN 1471-2407 R&D Projects: GA ČR GAP304/10/1286 Institutional support: RVO:68378041 Keywords : colorectal cancer * circulating miRNAs * miR-34a * miR-150 * miR-923 Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.362, year: 2014

  13. The Association Between Postnatal Depression, Acculturation and Mother-Infant Bond Among Eritrean Asylum Seekers in Israel.

    Science.gov (United States)

    Nakash, Ora; Nagar, Maayan; Lurie, Ido

    2016-10-01

    We examined the association between postnatal depression (PND), acculturation and mother-infant bond among 38 Eritrean asylum seekers in Israel, who were within 6 months of delivery. Participants completed a survey in their native language. A high rate of women (81.6 %) met the clinical threshold for PND on the Edinburgh Postnatal Depression Scale. Higher severity of PND (partial r = -.64, p < .001), higher identification with Israeli culture (partial r = -.45, p = .02), and lower quality of romantic relationship were associated with impaired mother-infant bond (partial r = .58, p = .002). Findings highlight the need to establish services to screen and treat PND among this vulnerable population in the receiving countries. PMID:26864379

  14. [Sequential traumatization, trauma-related disorders and psychotherapeutic approaches in war-traumatized adult refugees and asylum seekers in Germany].

    Science.gov (United States)

    Böttche, Maria; Heeke, Carina; Knaevelsrud, Christine

    2016-05-01

    The impact of war and violence on the mental and physical health of the civilian population is immense. Traumatization is often experienced sequentially, which leads to a higher risk for developing trauma-related disorders (PTSD, depression, chronic pain).Refugees traumatized by war experience specific stressors related to their status of residence (e. g., application hearing, length of the asylum procedure). Together with limited access to health care, these constitute additional risk factors for developing somatic and psychological illnesses.Adequate treatment for this highly vulnerable group requires a multimodal approach facilitated by translators. According to the S3 guidelines (S3-Richtlinien), trauma-adapted psychotherapeutic treatment has to be complemented by the activities of social workers, by medical treatment, and by legal advice. PMID:27072498

  15. Violence Against Women and Asylum Seeking: Global Problems and Local Practices Applied to Guatemalan Women Immigrating for Safety

    Directory of Open Access Journals (Sweden)

    Roselyn Costantino

    2012-05-01

    Full Text Available This paper, based on broader discussions surrounding gender violence and immigration in the U.S., provides critical information on the historical context of extreme violence against women and femicide plaguing Central American societies today. Drawing on experiences of precedent setting cases of Guatemalan women, the authors offer suggestions for culturally specific treatment of and support for women who seek asylum in the U.S. out of justified fear for their and their family members’ lives should they return to their country of origin. The arguments presented are predicated on the belief that women worldwide share experiences of myriad forms of male domination and gender inequality which, however, play out differently on their bodies and lives in ways that must be accounted for in our attempt to offer them appropriate care and assist them in creating the tools they need to change their circumstances.

  16. Longevity of Lake Superior lake trout

    Science.gov (United States)

    Schram, Stephen T.; Fabrizio, Mary C.

    1998-01-01

    The age structure of mature lake trout Salvelinus namaycush from the Wisconsin waters of Lake Superior increased following a population recovery that has taken place since the 1960s. As the population aged, it became apparent that scales were unreliable aging structures. Beginning in 1986, we examined both scale and sagittal otolith ages from tagged fish with a known period at liberty. We found large discrepancies in scale and sagittal otolith ages of mature fish, such that scale ages were biased low. We estimated lake trout living up to 42 years, which is greater than previously reported from Lake Superior. Investigators studying lake trout population dynamics in the Great Lakes should be aware that lake trout can live longer than previously thought.

  17. Challenges in the miRNA research

    DEFF Research Database (Denmark)

    Singh, Tiratha Raj; Gupta, Arun; Suravajhala, Prashanth

    2013-01-01

    While it is known that the human genes are regulated by microRNAs (miRNAs), recent links with cancer and other diseases have widely caught interest. With several bioinformatics platforms and approaches on rise that has led to discovery of human miRNAs, validation and need for understanding mi...

  18. miRConnect:Identifying effector genes of miRNAs and miRNA families in cancer cells

    DEFF Research Database (Denmark)

    Hua, Youjia; Duan, Shiwei; Murmann, Andrea E;

    2011-01-01

    biological state of the cell and, hence, of the function of the expressed miRNAs. We have compared the large amount of available gene array data on the steady state system of the NCI60 cell lines to two different data sets containing information on the expression of 583 individual miRNAs. In addition, we......) in addition to the known EMT regulators of the miR-200 miRNA family. In addition, an analysis of gene signatures associated with EMT, c-MYC activity, and ribosomal protein gene expression allowed us to assign different activities to each of the functional clusters of miRNAs. All correlation data are...

  19. miRNAs in brain development

    International Nuclear Information System (INIS)

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function

  20. Environmental impact of Hurricane Katrina on Lake Pontchartrain: Chapter 7G in Science and the storms-the USGS response to the hurricanes of 2005

    Science.gov (United States)

    Heitmuller, Thomas; Perez, Brian C.

    2007-01-01

    Hurricane Katrina slammed the Louisiana-Mississippi Gulf Coast with 135-mi/hour (217-km/hour) winds and up to a 30-ft (9-m) storm surge. Lake Pontchartrain was further subjected to environmental threat by way of the millions of gallons of contaminated flood water that were pumped daily from the city of New Orleans into the lake.

  1. Bathymetry of Lake Erie and Lake Saint Clair

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Bathymetry of Lake Erie and Lake Saint Clair has been compiled as a component of a NOAA project to rescue Great Lakes lake floor geological and geophysical data and...

  2. Potential role of miR-9 and miR-223 in recurrent ovarian cancer

    Directory of Open Access Journals (Sweden)

    McGuinness Eamonn

    2008-04-01

    Full Text Available Abstract Background MicroRNAs (miRNAs are small, noncoding RNAs that negatively regulate gene expression by binding to target mRNAs. miRNAs have not been comprehensively studied in recurrent ovarian cancer, yet an incurable disease. Results Using real-time RT-PCR, we obtained distinct miRNA expression profiles between primary and recurrent serous papillary ovarian adenocarcinomas (n = 6 in a subset of samples previously used in a transcriptome approach. Expression levels of top dysregulated miRNA genes, miR-223 and miR-9, were examined using TaqMan PCR in independent cohorts of fresh frozen (n = 18 and FFPE serous ovarian tumours (n = 22. Concordance was observed on TaqMan analysis for miR-223 and miR-9 between the training cohort and the independent test cohorts. Target prediction analysis for the above miRNA "recurrent metastatic signature" identified genes previously validated in our transcriptome study. Common biological pathways well characterised in ovarian cancer were shared by miR-9 and miR-223 lists of predicted target genes. We provide strong evidence that miR-9 acts as a putative tumour suppressor gene in recurrent ovarian cancer. Components of the miRNA processing machinery, such as Dicer and Drosha are not responsible for miRNA deregulation in recurrent ovarian cancer, as deluded by TaqMan and immunohistochemistry. Conclusion We propose a miRNA model for the molecular pathogenesis of recurrent ovarian cancer. Some of the differentially deregulated miRNAs identified correlate with our previous transcriptome findings. Based on integrated transcriptome and miRNA analysis, miR-9 and miR-223 can be of potential importance as biomarkers in recurrent ovarian cancer.

  3. Physiological roles of miR-155.

    Science.gov (United States)

    Mashima, Ryuichi

    2015-07-01

    miR-155 is involved in non-coding microRNAs found in humans, mice and chickens of which the sequence is conserved. Historically, miR-155 was identified as a B-cell integration cluster (bic), which induces B-cell leucosis in chickens, by its activation through viral promoter insertion. Subsequent studies have shown that transgenic mice expressing miR-155 in B cells generated lymphoma, showing that miR-155 is oncogenic. Biochemical investigation identifies many substrates of miR-155, and one of them in B cells and macrophages is the SH2-domain containing inositol-5'-phosphatase 1. A deficiency of miR-155 in the immune system causes attenuated immune functions. Clinically, several types of malignancy including diffuse large B-cell lymphoma have high miR-155 expression levels. PMID:25829072

  4. Sexual health is dead in my body: participatory assessment of sexual health determinants in refugees, asylum seekers and undocumented migrants in Belgium and the Netherlands

    OpenAIRE

    Keygnaert, Ines; Vettenburg, Nicole; Roelens, Kristien; Temmerman, Marleen

    2014-01-01

    Background: Although migrants constitute an important proportion of the European population, little is known about migrant sexual health. Existing research mainly focuses on migrants' sexual health risks and accessibility issues while recommendations on adequate sexual health promotion are rarely provided. Hence, this paper explores how refugees, asylum seekers and undocumented migrants in Belgium and the Netherlands define sexual health, search for sexual health information and perceive sexu...

  5. Paraprofessional counselling within asylum seekers' groups in the Netherlands: transferring an approach for a non-western context to a European setting.

    Science.gov (United States)

    Kieft, Barbara; Jordans, Mark J D; de Jong, Joop T V M; Kamperman, Astrid M

    2008-03-01

    This article presents the application of a psychosocial care approach, which has been developed for and in a non-western context, within an asylum seekers' setting in the Netherlands. The project aimed to increase access to basic psychosocial care to a target population that experiences difficulties in entering mental healthcare services, by a group of trained peer asylum seekers and refugees. The development of an informal paraprofessional support system makes better use of existing resources, provides secondary benefits for the participants and helps to overcome the treatment gap between perceived needs and the formal mental healthcare system. The article describes the key components of such an approach, the Dutch context, the project implementation and finishes with a discussion on outcomes, strengths and weaknesses, risks and recommendations. In summary, we found this community approach to be applicable and relevant within an asylum seekers' centre, as it incorporates an additional easy-access level of psychosocial care and social agency, which seemed to empower participants and help prevent psychosocial problems from becoming more severe. PMID:18344254

  6. High Prevalence of Infectious Diseases and Drug-Resistant Microorganisms in Asylum Seekers Admitted to Hospital; No Carbapenemase Producing Enterobacteriaceae until September 2015

    Science.gov (United States)

    Ravensbergen, Sofanne J.; Lokate, Mariëtte; Cornish, Darren; Kloeze, Eveline; Ott, Alewijn; Friedrich, Alex W.; van Hest, Rob; Akkerman, Onno W.; de Lange, Wiel C.; van der Werf, Tjip S.; Bathoorn, Erik

    2016-01-01

    Introduction The current refugee crisis emphasizes the need for information on infectious diseases and resistant microorganisms in asylum seekers with possible consequences for public health and infection control. Methods We collected data from asylum seekers admitted to our university hospital or who presented at the Emergency Department (n = 273). We collected general and demographic characteristics including country of origin, the reason of presentation, and the screening results of multi-drug resistant organisms. Results 67% of the patients were male with a median age of the study group of 24 years (IQR 15–33); 48% of the patients had an infectious disease—predominantly malaria with P. vivax or tuberculosis. Patients also reported with diseases which are less common—e.g. leishmaniasis, or even conditions rarely diagnosed in Europe—e.g. louse borne relapsing fever. A carriage rate of 31% for multi-drug resistant microorganisms (MDRO) was observed, with ESBL-expressing E.coli (n = 20) being the most common MDRO. No carriage of Carbapenemase Producing Enterobacteriaceae was found. Conclusion The current refugee crisis in Europe challenges hospitals to quickly identify and respond to communicable diseases and the carriage of MDRO. A rapid response is necessary to optimize the treatment of infectious diseases amongst asylum seekers to maximize infection control. PMID:27144599

  7. High Prevalence of Infectious Diseases and Drug-Resistant Microorganisms in Asylum Seekers Admitted to Hospital; No Carbapenemase Producing Enterobacteriaceae until September 2015.

    Directory of Open Access Journals (Sweden)

    Sofanne J Ravensbergen

    Full Text Available The current refugee crisis emphasizes the need for information on infectious diseases and resistant microorganisms in asylum seekers with possible consequences for public health and infection control.We collected data from asylum seekers admitted to our university hospital or who presented at the Emergency Department (n = 273. We collected general and demographic characteristics including country of origin, the reason of presentation, and the screening results of multi-drug resistant organisms.67% of the patients were male with a median age of the study group of 24 years (IQR 15-33; 48% of the patients had an infectious disease-predominantly malaria with P. vivax or tuberculosis. Patients also reported with diseases which are less common-e.g. leishmaniasis, or even conditions rarely diagnosed in Europe-e.g. louse borne relapsing fever. A carriage rate of 31% for multi-drug resistant microorganisms (MDRO was observed, with ESBL-expressing E.coli (n = 20 being the most common MDRO. No carriage of Carbapenemase Producing Enterobacteriaceae was found.The current refugee crisis in Europe challenges hospitals to quickly identify and respond to communicable diseases and the carriage of MDRO. A rapid response is necessary to optimize the treatment of infectious diseases amongst asylum seekers to maximize infection control.

  8. MiRNA profiles of prostate carcinoma detected by multi-platform miRNA screening

    DEFF Research Database (Denmark)

    Wach, Sven; Nolte, Elke; Szczyrba, Jaroslaw; Stöhr, Robert; Hartmann, Arndt; Orntoft, Torben; Andersen, Lars Dyrskjøt; Eltze, Elke; Wieland, Wolf; Keck, Bastian; Ekici, Arif B; Grässer, Friedrich; Wullich, Bernd

    MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression via posttranscriptional inhibition of protein synthesis. They play a vital role in tumorigenesis. To characterize the diagnostic potential of miRNAs in prostate cancer, a leading cause of cancer mortality, we performed...... screening of miRNA expression profiles. We used commercially available microarrays to establish miRNA expression profiles from a cohort of 20 cancer samples. The expression of selected miRNAs was analyzed by quantitative real-time PCR and the identity of miRNA expressing cells was determined by miRNA in...... situ hybridization. We identified 25 miRNAs that showed a significant differential expression in cancer samples. The comparison with previously published data generated by deep sequencing of cDNA libraries of small RNA molecules revealed a concordance rate of 47% among miRNAs identified with both...

  9. The regulatory epicenter of miRNAs

    Indian Academy of Sciences (India)

    Ashwani Jha; Mrigaya Mehra; Ravi Shankar

    2011-09-01

    miRNAs are small non-coding RNAs with average length of ∼21 bp. miRNA formation seems to be dependent upon multiple factors besides Drosha and Dicer, in a tissue/stage-specific manner, with interplay of several specific binding factors. In the present study, we have investigated transcription factor binding sites in and around the genomic sequences of precursor miRNAs and RNA-binding protein (RBP) sites in miRNA precursor sequences, analysed and tested in comprehensive manner. Here, we report that miRNA precursor regions are positionally enriched for binding of transcription factors as well as RBPs around the 3′ end of mature miRNA region in 5′ arm. The pattern and distribution of such regulatory sites appears to be a characteristic of precursor miRNA sequences when compared with non-miRNA sequences as negative dataset and tested statistically. When compared with 1 kb upstreamregions, a sudden sharp peak for binding sites arises in the enriched zone near the mature miRNA region. An expression-data-based correlation analysis was performed between such miRNAs and their corresponding transcription factors and RBPs for this region. Some specific groups of binding factors and associated miRNAs were identified. We also identified some of the overrepresented transcription factors and associated miRNAs with high expression correlation values which could be useful in cancer-related studies. The highly correlated groups were found to host experimentally validated composite regulatory modules, in which Lmo2-GATA1 appeared as the predominant one. For many of RBP–miRNAs associations, co-expression similarity was also evident among the associated miRNA common to given RBPs, supporting the Regulon model, suggesting a common role and common control of these miRNAs by the associated RBPs. Based on our findings, we propose that the observed characteristic distribution of regulatory sites in precursor miRNA sequence regions could be critical inmiRNA transcription, processing

  10. ZHOUZHUANG, A "TOWN IN LAKES"

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Zhouzhuang Town islocated in thesouthwestern part ofKunshan City,neighboring WujiangCity, Suzhou City andQingpu District ofShanghai City, andsurrounded by ChengLake, Changbai Lake,Dianshan Lake, BaiyiLake and South Lake, asknown as a "town in lakes".

  11. miRNA-based drought regulation in wheat.

    Science.gov (United States)

    Akdogan, Guray; Tufekci, Ebru Derelli; Uranbey, Serkan; Unver, Turgay

    2016-05-01

    MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs that regulate gene expression by guiding target mRNA cleavage or translational inhibition. Drought is a common environmental stress influencing crop growth and development. To date, it has been reported that a number of plant miRNA are involved in drought stress response. In this study, we comparatively investigated drought stress-responsive miRNAs in the root and leaf of bread wheat (Triticum aestivum cv. Sivas 111/33) by miRNA microarray screening. miRNA microarray analysis showed that 285 miRNAs (207 upregulated and 78 downregulated) and 244 miRNAs (115 upregulated and 129 downregulated) were differentially expressed in leaf and root tissues, respectively. Among the differentially expressed miRNAs, 23 miRNAs were only expressed in the leaf and 26 miRNAs were only expressed in the root of wheat growth under drought stress. Upon drought treatment, expression of miR159, miR160, miR166, miR169, miR172, miR395, miR396, miR408, miR472, miR477, miR482, miR1858, miR2118, and miR5049 were found to be significantly differentiated in bread wheat. The regulatory network analysis showed that miR395 has connections with a number of target transcripts, and miR159 and miR319 share a number of target genes. Drought-tolerant and drought-sensitive wheat cultivars showed altered expression pattern upon drought stress in terms of investigated miRNA and their target transcript expression level. PMID:26141043

  12. National Lakes Assessment Data

    Data.gov (United States)

    U.S. Environmental Protection Agency — The National Lakes Assessment (NLA) is a first-ever statistically-valid survey of the biological condition of lakes and reservoirs throughout the U.S. The U.S....

  13. DNR 24K Lakes

    Data.gov (United States)

    Minnesota Department of Natural Resources — Medium scale lake polygons derived from the National Wetlands Inventory (NWI) polygons and MnDOT Basemap lake delineations. Integrated with the DNR 24K Streams...

  14. Comparative Analysis of Pollution in Farmington Bay and the Great Salt Lake, Utah

    OpenAIRE

    Wurtsbaugh, Wayne A.; Marcarelli, Amy; Christison, Cameron; Moore, Joel; Gross, Donovan; Bates, Sophia; Kircher, Sara

    2002-01-01

    Farmington Bay covers 94 mi2 (260 km2) in the SW comer of the Great Salt Lake, and is essentially a separate lake because it is enclosed by Antelope Island and a causeway leading to the island from the mainland. The bay has received wastes from the adjoining Salt Lake City metropolitan area for decades. Because of water quality concerns for Farmington 8ay, the Aquatic Ecology Laboratory class at Utah State University studied the bay and a nearby control site (Bridger Bay) in the Great Salt La...

  15. Technologies for lake restoration

    OpenAIRE

    Helmut KLAPPER

    2003-01-01

    Lakes are suffering from different stress factors and need to be restored using different approaches. The eutrophication remains as the main water quality management problem for inland waters: both lakes and reservoirs. The way to curb the degradation is to stop the nutrient sources and to accelerate the restoration with help of in-lake technologies. Especially lakes with a long retention time need (eco-) technological help to decrease the nutrient content in the free water. The microbial and...

  16. Measuring the health impact of human rights violations related to Australian asylum policies and practices: a mixed methods study

    Directory of Open Access Journals (Sweden)

    Mulholland Kim

    2009-02-01

    Full Text Available Abstract Background Human rights violations have adverse consequences for health. However, to date, there remains little empirical evidence documenting this association, beyond the obvious physical and psychological effects of torture. The primary aim of this study was to investigate whether Australian asylum policies and practices, which arguably violate human rights, are associated with adverse health outcomes. Methods We designed a mixed methods study to address the study aim. A cross-sectional survey was conducted with 71 Iraqi Temporary Protection Visa (TPV refugees and 60 Iraqi Permanent Humanitarian Visa (PHV refugees, residing in Melbourne, Australia. Prior to a recent policy amendment, TPV refugees were only given temporary residency status and had restricted access to a range of government funded benefits and services that permanent refugees are automatically entitled to. The quantitative results were triangulated with semi-structured interviews with TPV refugees and service providers. The main outcome measures were self-reported physical and psychological health. Standardised self-report instruments, validated in an Arabic population, were used to measure health and wellbeing outcomes. Results Forty-six percent of TPV refugees compared with 25% of PHV refugees reported symptoms consistent with a diagnosis of clinical depression (p = 0.003. After controlling for the effects of age, gender and marital status, TPV status made a statistically significant contribution to psychological distress (B = 0.5, 95% CI 0.3 to 0.71, p ≤ 0.001 amongst Iraqi refugees. Qualitative data revealed that TPV refugees generally felt socially isolated and lacking in control over their life circumstances, because of their experiences in detention and on a temporary visa. This sense of powerlessness and, for some, an implicit awareness they were being denied basic human rights, culminated in a strong sense of injustice. Conclusion Government asylum policies

  17. The Importance of Resources and Security in the Socio-Economic Integration of Refugees. A Study on the Impact of Length of Stay in Asylum Accommodation and Residence Status on Socio-Economic Integration for the Four Largest Refugee Groups in the Netherlands

    NARCIS (Netherlands)

    L. Bakker (Linda); J.M. Dagevos (Jaco); G.B.M. Engbersen (Godfried)

    2013-01-01

    textabstractIn many European countries, including the Netherlands, refugees stay in asylum accommodation pending a decision on their asylum request. While it seems evident that the lack of resources and insecurity about the future experienced during this stay will impact refugees' subsequent ability

  18. Circulating miRNA and cancer diagnosis

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    miRNAs are a class of small RNA molecules with regulatory function, and play an important role in tumor development and progression. It has been demonstrated that tumor-derived miRNAs exist in the circulating nucleic acids of cancer patients. This phenomenon implies that detection of the circulating miRNA may be an effective method for non-invasive diagnosis of cancer. In this review, we summarize the applications of the circulating miRNA as biomarkers in cancer diagnosis, as well as the latest research progress in this area.

  19. Michigan Molecular Interactions (MiMI): putting the jigsaw puzzle together

    OpenAIRE

    Jayapandian, Magesh; Chapman, Adriane; Tarcea, V. Glenn; Yu, Cong; Elkiss, Aaron; Ianni, Angela; Liu, Bin; Nandi, Arnab; Santos, Carlos; Andrews, Philip; Athey, Brian; States, David; Jagadish, H.V.

    2006-01-01

    Protein interaction data exists in a number of repositories. Each repository has its own data format, molecule identifier and supplementary information. Michigan Molecular Interactions (MiMI) assists scientists searching through this overwhelming amount of protein interaction data. MiMI gathers data from well-known protein interaction databases and deep-merges the information. Utilizing an identity function, molecules that may have different identifiers but represent the same real-world objec...

  20. Integrating and annotating the interactome using the MiMI plugin for cytoscape

    OpenAIRE

    Gao, Jing; Ade, Alex S; Tarcea, V. Glenn; Weymouth, Terry E.; Mirel, Barbara R.; Jagadish, H.V.; States, David J.

    2008-01-01

    Summary: The MiMI molecular interaction repository integrates data from multiple sources, resolves interactions to standard gene names and symbols, links to annotation data from GO, MeSH and PubMed and normalizes the descriptions of interaction type. Here, we describe a Cytoscape plugin that retrieves interaction and annotation data from MiMI and links out to multiple data sources and tools. Community annotation of the interactome is supported.

  1. Identification of novel miRNAs and miRNA expression profiling in wheat hybrid necrosis.

    Directory of Open Access Journals (Sweden)

    Jianping Zhou

    Full Text Available MicroRNAs (miRNAs play essential roles in a vast array of biological processes, including growth and development, defense against viral infection, and responses to environmental changes in plant. Wheat hybrid necrosis is an interesting genetic phenomenon observed frequency and it is lethal or semi lethal, resulting in gradual death or loss of productivity. However, the molecular basis and mechanisms associated with hybrid necrosis in wheat are still not well understood. Here, we report the population and expression profiles of miRNAs in wheat hybrid necrosis. We identified a total of 57 conserved miRNA families as well as 182 putative novel miRNAs. Expression profiling revealed that expression of 49 known miRNAs and 165 novel miRNAs was changed in hybrid necrosis. And the expression levels of some miRNAs and their predicated targets have been confirmed by qRT-PCR. These results indicate that these miRNAs, especially miR159, miR166, miR167 and miR5072 could be involved in the extensive regulation of gene expression in response to hybrid necrosis.

  2. A group-based approach to stabilisation and symptom management in a phased treatment model for refugees and asylum seekers

    Directory of Open Access Journals (Sweden)

    Mary E. A. Robertson

    2013-12-01

    Full Text Available Background: Traumatised asylum seekers and refugees may present with significant and complex mental health problems as a result of prolonged, extreme, and multiple traumatic events. This is further complicated by ongoing complex social circumstances. Concepts: In our work at the Traumatic Stress Clinic (TSC, the understanding afforded by the concept of complex posttraumatic stress disorder (PTSD together with the related notion of a phased treatment model, provides a useful framework for organising our work with this population. Clinical Applications: An explication of complex PTSD as it applies to our client group is presented, followed by a description of our phased treatment model and an outline of the core principles, which guide our clinical approach. Our symptom management and stabilisation groups have been developed and refined over time and draw on techniques from a variety of cognitive behavioural therapies. These are described in some detail with illustrative clinical case vignettes. Conclusion: This paper concludes with some reflections on the challenges inherent to working with this complex client group.

  3. Political representation for social justice in nursing: lessons learned from participant research with destitute asylum seekers in the UK.

    Science.gov (United States)

    Cuthill, Fiona

    2016-09-01

    The concept of social justice is making a revival in nursing scholarship, in part in response to widening health inequalities and inequities in high-income countries. In particular, critical nurse scholars have sought to develop participatory research methods using peer researchers to represent the 'voice' of people who are living in marginalized spaces in society. The aim of this paper is to report on the experiences of nurse and peer researchers as part of a project to explore the experiences of people who find themselves destitute following the asylum process in the UK. In seeking to explore social injustice, three challenges are identified: lack of a robust political theory, institutional/professional constraints and an absence of skills to engage with the politics of social (in)justice. Each challenge is presented, opposing voices outlined and some possible solutions are suggested. The work of political theorist Nancy Fraser is used as a conceptual framework, in particular her focus on mis/framing and political representation for social justice. In addition, it is suggested that social justice needs to be further embedded in nursing policy and curriculum. Finally, nurses are encouraged to develop practical political skills to engage with both politics and the media in a neoliberal globalizing world. PMID:27562573

  4. Some Lake Level Control Alternatives for the Great Salt Lake

    OpenAIRE

    Allen, Marvin E.; Christensen, Ronald K.; Riley, J. Paul

    1983-01-01

    Fluctuations of the level of the Great Salt Lake cause large changes in both surface area and shoreline. Developments adjacent to the lake have been damaged by both high and low lake levels; and unless measures are implemented to regulate lake level fluctuations or otherwise to protect these developments, damages will continue. Various possible managment alternatives for mitigating potential damages from lake leve...

  5. MiRNA Biogenesis and Intersecting Pathways

    DEFF Research Database (Denmark)

    Ben Chaabane, Samir

    MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Plant miRNAs are critical for plant growth, development and stress response, and are processed in Arabidopsis from primary miRNA transcripts (pri-miRNAs) by the endonuclease activity of the DICER-LIKE1...... (DCL1) protein complex. Mature miRNAs are loaded onto and guide an ARGONAUTE1 (AGO1) effector complex, leading to target mRNA silencing. The miRNA pathway is under tight temporal and spatial control and is regulated at multiple levels from transcription and precursor processing through miRNA mode of...... action and turnover. During my PhD period we have shown that the STA1 protein, a factor for pre-mRNA splicing and mRNA stability, is specifically involved in the splicing of pri-miRNAs and in the modulation of DCL1 transcript levels. Also, we established a novel and essential regulatory network in which...

  6. Lake retention of manufactured nanoparticles

    NARCIS (Netherlands)

    Koelmans, A.A.; Quik, J.T.K.; Velzeboer, I.

    2015-01-01

    For twenty-five world lakes and three engineered nanoparticles (ENP), lake retention was calculated using a uniformly mixed lake mass balance model. This follows similar approaches traditionally used in water quality management. Lakes were selected such that lake residence times, depths and areal hy

  7. "They think we're OK and we know we're not". A qualitative study of asylum seekers' access, knowledge and views to health care in the UK

    Directory of Open Access Journals (Sweden)

    Mullen Kenneth

    2007-05-01

    Full Text Available Abstract Background The provision of healthcare for asylum seekers is a global issue. Providing appropriate and culturally sensitive services requires us to understand the barriers facing asylum seekers and the facilitators that help them access health care. Here, we report on two linked studies exploring these issues, along with the health care needs and beliefs of asylum seekers living in the UK. Methods Two qualitative methods were employed: focus groups facilitated by members of the asylum seeking community and interviews, either one-to-one or in a group, conducted through an interpreter. Analysis was facilitated using the Framework method. Results Most asylum seekers were registered with a GP, facilitated for some by an Asylum Support nurse. Many experienced difficulty getting timely appointments with their doctor, especially for self-limiting symptoms that they felt could become more serious, especially in children. Most were positive about the health care they received, although some commented on the lack of continuity. However, there was surprise and disappointment at the length of waiting times both for hospital appointments and when attending accident and emergency departments. Most had attended a dentist, but usually only when there was a clinical need. The provision of interpreters in primary care was generally good, although there was a tension between interpreters translating verbatim and acting as patient advocates. Access to interpreters in other settings, e.g. in-patient hospital stays, was problematic. Barriers included the cost of over-the-counter medication, e.g. children's paracetamol; knowledge of out-of-hours medical care; and access to specialists in secondary care. Most respondents came from countries with no system of primary medical care, which impacted on their expectations of the UK system. Conclusion Most asylum seekers were positive about their experiences of health care. However, we have identified issues

  8. The Impact of Direct Provision Accommodation for Asylum Seekers on Organisation and Delivery of Local Primary Care and Social Care Services: A Case Study

    LENUS (Irish Health Repository)

    Pieper, Hans-Olaf

    2011-05-15

    Abstract Background Many western countries have policies of dispersal and direct provision accommodation (state-funded accommodation in an institutional centre) for asylum seekers. Most research focuses on its effect on the asylum seeking population. Little is known about the impact of direct provision accommodation on organisation and delivery of local primary care and social care services in the community. The aim of this research is to explore this issue. Methods In 2005 a direct provision accommodation centre was opened in a rural area in Ireland. A retrospective qualitative case study was designed comprising in-depth interviews with 37 relevant stakeholders. Thematic analysis following the principles of framework analysis was applied. Results There was lack of advance notification to primary care and social care professionals and the community about the new accommodation centre. This caused anxiety and stress among relevant stakeholders. There was insufficient time to plan and prepare appropriate primary care and social care for the residents, causing a significant strain on service delivery. There was lack of clarity about how primary care and social care needs of the incoming residents were to be addressed. Interdisciplinary support systems developed informally between healthcare professionals. This ensured that residents of the accommodation centre were appropriately cared for. Conclusions Direct provision accommodation impacts on the organisation and delivery of local primary care and social care services. There needs to be sufficient advance notification and inter-agency, inter-professional dialogue to manage this. Primary care and social care professionals working with asylum seekers should have access to training to enhance their skills for working in cross-cultural consultations.

  9. IN WHICH DIRECTION DO THE EFFORTS PROCEED? THE EUROPEAN UNION’S ATTEMPTS TO DEVELOP A COMMON IMMIGRATION AND ASYLUM POLICY

    OpenAIRE

    Şirin Öner, N. Aslı

    2015-01-01

    In the period which began in the mid-1980s and continued until today, there has been an increase in the number of refugees, asylum-seekers and irregular migrants. The Central and Eastern Europeans, who had the opportunity to participate in the migration movements with the removal of the political barriers and the persons displaced as a result of bloody conflicts in the Balkans played an important role in the increase in the number of people migrating to the Western Europe. The increase in the...

  10. Pollution at Lake Mariut

    International Nuclear Information System (INIS)

    Lake Mariut, south Alexandria, Egypt suffered in the recent decades from intensive pollution as a result of a continuous discharge of huge amounts of agriculture wastewater that contains a large concentration of the washed pesticides and fertilizers in addition to domestic and industrial untreated wastewater. The over flow from the lake is discharged directly to the sea through El-Max pumping station via EI-Umum drain. Lake Mariout is surrounded by a huge number of different industrial activities and also the desert road is cutting the lake, this means that a huge number of various pollutants cycle through the air and settle down in the lake, by the time and during different seasons these pollutants after accumulation and different chemical interactions will release again from the lake to the surrounding area affecting the surrounding zone

  11. Origins of rainbow smelt in Lake Ontario

    Science.gov (United States)

    Bergstedt, Roger A.

    1983-01-01

    The first rainbow smelt (Osmerus mordax) to enter Lake Ontario were probably migrants from an anadromous strain introduced into New York's Finger Lakes. Since the upper Great Lakes were originally stocked with a landlocked strain from Green Lake, Maine, subsequent migration to Lake Ontario from Lake Erie makes Lake Ontario unique among the Great Lakes in probably having received introductions from two distinct populations.

  12. Mi oíslo

    Directory of Open Access Journals (Sweden)

    Mitja Skubic

    2006-05-01

    Full Text Available Hablando Sancho en su primer encuentro con don Quijote de su mujer Juana Gutiérrez, llamada en seguida Teresa Panza o simplemente Teresa, la nombra mi oíslo y repite lo mismo otras dos veces. Conviene tener presente que de su mujer Sancho habla siempre respetuosamente y con mucho cariño, con excepción de una conversación que llega a ser un litigio, II, 5. Allí, Sancho expresa su idea de cómo y con quién casar a la hija Sanchica y por fin impone su voluntad. Teresa se le opone vigorosamente y esto induce a Sancho, sobreexcitado, a formular una gradación sorprendente: mujer mía; mirad, Teresa; mujer; calla, boba; bestia y mujer de Barrabás; animalia; mentecata e ignorante.

  13. Boat Dwellers of Weishan Lake

    Institute of Scientific and Technical Information of China (English)

    JENNIFER; LIM

    1998-01-01

    IN the south of Shandong Province, Weishan Lake is the largest freshwater lake in northern China. Under the bright blue sky, it gleams like a large mirror. "As the sun is about to set, Weishan Lake is quiet…" Humming

  14. Hydrography - Lakes Assessments - Non Attaining

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This layer shows only non attaining lakes of the Integrated List. The Lakes Integrated List represents lake assessments in an integrated format for the Clean Water...

  15. Benthic diatoms in lakes

    OpenAIRE

    Gottschalk, Steffi

    2014-01-01

    In order to protect or improve surface waters ecosystem response to pressures needs to be quantified. Diatoms are frequently used for assessing ecological status in streams and for reconstructing water quality of lakes. However, ecological status assessment of European lakes based on extant diatom assemblages is rare. The overall aim of this thesis is to facilitate the application of benthic diatoms in water quality assessment of boreal lakes, using methods developed for stream assessmen...

  16. Yellowstone Lake Nanoarchaeota

    OpenAIRE

    Scott eClingenpeel; Jinjun eKan; Rich eMacur; Tanja eWoyke; Dave eLovalvo; John eVarley; Inskeep, William P.; Kenneth eNealson; Tim eMcDermott

    2013-01-01

    Considerable Nanoarchaeota novelty and diversity were encountered in Yellowstone Lake, Yellowstone National Park (YNP), where sampling targeted lake floor hydrothermal vent fluids, streamers and sediments associated with these vents, and in planktonic photic zones in three different regions of the lake. Significant homonucleotide repeats (HR) were observed in pyrosequence reads and in near full-length Sanger sequences, averaging 112 HR per 1349 bp clone and could confound diversity estimates ...

  17. A lake without water

    OpenAIRE

    Nagoli, Joseph

    2016-01-01

    This thesis explores the human-environment interaction within the climate-sensitive socio-ecological system of Lake Chilwa in Malawi. It uses the livelihoods framework to analyse various coping strategies to resource scarcity due to lake recessions. The main aim is to understand the processes by which decision-making takes place and the influence of various agents of change on coping with environmental shocks, i.e. water recessions. Lake Chilwa undergoes periodic water recessions with up to t...

  18. Marine lakes of Indonesia

    OpenAIRE

    Becking, Leontine Elisabeth

    2012-01-01

    The objective of this thesis was to obtain insight into the processes that play a role in biodiversity patterns of tropical marine species by using marine lakes as a model. Marine lakes are landlocked water bodies that maintain a marine character through narrow submarine connections to the sea. Two regions in Indonesia were studied: Berau (East Kalimantan) and Raja Ampat (West Papua). The following questions were addressed: 1. What are the different types of marine lakes in Indonesia? 2. Are ...

  19. A instituição asilar como fator potencializador da disfagia The asylum as worsening factor for dysphagia

    Directory of Open Access Journals (Sweden)

    Ana Maria Furkim

    2010-12-01

    Full Text Available OBJETIVO: verificar se as condições referentes à estrutura geral dos asilos, recursos humanos e rotinas diárias de alimentação em instituições asilares, podem potencializar alterações da dinâmica da deglutição em idosos. MÉTODOS: foi aplicado questionário aos dirigentes de cinco instituições asilares do município do Rio de Janeiro, no qual constavam perguntas em relação aos recursos materiais, humanos e rotina alimentar. RESULTADOS: o asilo do sistema privado foi o único a aproximar-se das condições ideais da estrutura geral para o atendimento do idoso. Em relação aos recursos humanos existentes, nenhum dos asilos possuía todos os profissionais exigidos pela portaria nº810/89. Em relação às rotinas diárias de alimentação, em uma das instituições pesquisadas, cuja maioria dos residentes não faziam uso de próteses dentárias, não havia restrição na consistência alimentar oferecida. Outro fator significativo diz respeito à negligência referente à higiene bucal, favorecendo a colonização de bactérias na cavidade oral, podendo agravar infecções pulmonares no caso de microaspirações. O fato dos idosos deitarem para dormir logo após o término das refeições, como ocorrido em três das instituições pesquisadas, tem grande importância na medida em que favorece a ocorrência de episódios de refluxo gastroesofágico. CONCLUSÃO: foram observados que em todas as instituições pesquisadas há fatores que podem potencializar um distúrbio de deglutição, como problemas em relação à estrutura geral e ou aos recursos humanos e ou relativos à rotina alimentar estabelecida.PURPOSE: to check if the conditions related to general structure, human resources and daily routine of feeding in asylums can increase the chances for an alteration in the deglutition process of the elderlies. METHODS: a questionnaire was elaborated to be applied to the directors of five institutions in the city of Rio de Janeiro

  20. MiMiR – an integrated platform for microarray data sharing, mining and analysis

    Directory of Open Access Journals (Sweden)

    Maratou Klio

    2008-09-01

    Full Text Available Abstract Background Despite considerable efforts within the microarray community for standardising data format, content and description, microarray technologies present major challenges in managing, sharing, analysing and re-using the large amount of data generated locally or internationally. Additionally, it is recognised that inconsistent and low quality experimental annotation in public data repositories significantly compromises the re-use of microarray data for meta-analysis. MiMiR, the Microarray data Mining Resource was designed to tackle some of these limitations and challenges. Here we present new software components and enhancements to the original infrastructure that increase accessibility, utility and opportunities for large scale mining of experimental and clinical data. Results A user friendly Online Annotation Tool allows researchers to submit detailed experimental information via the web at the time of data generation rather than at the time of publication. This ensures the easy access and high accuracy of meta-data collected. Experiments are programmatically built in the MiMiR database from the submitted information and details are systematically curated and further annotated by a team of trained annotators using a new Curation and Annotation Tool. Clinical information can be annotated and coded with a clinical Data Mapping Tool within an appropriate ethical framework. Users can visualise experimental annotation, assess data quality, download and share data via a web-based experiment browser called MiMiR Online. All requests to access data in MiMiR are routed through a sophisticated middleware security layer thereby allowing secure data access and sharing amongst MiMiR registered users prior to publication. Data in MiMiR can be mined and analysed using the integrated EMAAS open source analysis web portal or via export of data and meta-data into Rosetta Resolver data analysis package. Conclusion The new MiMiR suite of software

  1. When the foundations of life have been upset... An integrated clinical and experimental study with refugees an asylum seekers

    Directory of Open Access Journals (Sweden)

    Schiltz, Lony

    2013-06-01

    Full Text Available Aim Recent research results in clinical psychology, health psychology and neurobiology underline the relationship between dissociative states, complex posttraumatic syndromes and borderline functioning [11]. Our study is meant to investigate the traumatic hypothesis of borderline functioning and to develop appropriate psychotherapeutic measures based on artistic mediations.Material and Methods.To estimate the effect of traumatic events, from the beginning of life up to recent stressors, linked to natural catastrophes, war, political persecution and migration, we undertook an integrated clinical and experimental study with a sample of 73 refugees and asylum seekers. In a second stage, those who suffered from PTSD or complex post-traumatic states were offered to attend arts psychotherapeutic sessions.To investigate the personality functioning at the structural level, we used a mixed quantitative and qualitative methodology, combining a semi-structured biographical interview, a projective test, i.e. the Sentences Completion Test, for which we developed a new manner of interpretation, and psychometric scales, i.e. the HADS and the Index of Wellbeing . Furthermore, we analysed the artistic production (pictures, stories written under musical induction with the help of rating scales constructed in the phenomenological and structural tradition.Results. With the help of non parametric multidimensional statistics, we extracted two profiles of personality functioning, linked either to repeated breaks, negligence and maltreatment from the beginningof life, or either to a recent external catastrophe, interrupting a continuous life course. Through the evaluation of the arts therapeutic sessions, we could note the first signs of resumption of the blocked process of subjectivation.Discussion.The results of the study support the traumatogenic hypothesis of borderline functioning, as well as current clinical considerations concerning the defensive role of

  2. The Key Lake project

    International Nuclear Information System (INIS)

    Key Lake is located in the Athabasca sand stone basin, 640 kilometers north of Saskatoon, Saskatchewan, Canada. The three sources of ore at Key Lake contain 70 100 tonnes of uranium. Features of the Key Lake Project were described under the key headings: work force, mining, mill process, tailings storage, permanent camp, environmental features, worker health and safety, and economic benefits. Appendices covering the historical background, construction projects, comparisons of western world mines, mining statistics, Northern Saskatchewan surface lease, and Key Lake development and regulatory agencies were included

  3. Great Lakes Literacy Principles

    Science.gov (United States)

    Fortner, Rosanne W.; Manzo, Lyndsey

    2011-03-01

    Lakes Superior, Huron, Michigan, Ontario, and Erie together form North America's Great Lakes, a region that contains 20% of the world's fresh surface water and is home to roughly one quarter of the U.S. population (Figure 1). Supporting a $4 billion sport fishing industry, plus $16 billion annually in boating, 1.5 million U.S. jobs, and $62 billion in annual wages directly, the Great Lakes form the backbone of a regional economy that is vital to the United States as a whole (see http://www.miseagrant.umich.edu/downloads/economy/11-708-Great-Lakes-Jobs.pdf). Yet the grandeur and importance of this freshwater resource are little understood, not only by people in the rest of the country but also by many in the region itself. To help address this lack of knowledge, the Centers for Ocean Sciences Education Excellence (COSEE) Great Lakes, supported by the U.S. National Science Foundation and the National Oceanic and Atmospheric Administration, developed literacy principles for the Great Lakes to serve as a guide for education of students and the public. These “Great Lakes Literacy Principles” represent an understanding of the Great Lakes' influences on society and society's influences on the Great Lakes.

  4. Jackson Lake Limnology

    OpenAIRE

    Wurtsbaugh, Wayne

    2014-01-01

    The limnology of Jackson Lake has been studied very little, despite the fact that it is the uppermost large lake on the headwaters of the Snake River, one of the larger rivers in the country (Hayden 1969). It is also an important fishery, largely for introduced lake trout. In 2014 we took our incoming graduate students to the Jackson Hole and one part of this introductory course focused on the limnology of the lake. Prior to the arrival of the students, a nutrient addition bioassay was initia...

  5. Paleolimnology of Kluane Lake

    OpenAIRE

    Brahney, Janice Lynne

    2007-01-01

    Causes and consequences of late Holocene fluctuations of Kluane Lake in Yukon Territory have been reconstructed from several sediment cores. In the last 5000 years the level of Kluane Lake has varied from ~27 m below its present level to 12 m above, primarily due to changes in inputs of water from Slims and Duke rivers. Discharge form the Slims River catchment into Kluane Lake is associated with glacial advances. During periods when neither Duke nor Slims rivers flowed into Kluane Lake, the l...

  6. Lake Qinghai, China

    OpenAIRE

    Yu, Junqing

    2006-01-01

    Lake Qinghai lies on the northeast corner of the Tibet-Qinghai Plateau. It is a closed-basin lake and the largest water body in China with an area of about 4437 km2. Aragonite and calcite are precipitating from the brackish (TDS 12-14 g/l) and alkaline water (pH 9.1-9.4). Summer rainfall exerts an important control on changes in both lake level and water chemistry. As the lake today is situated at the outer margin of the Asian summer monsoon, past climate changes were sensitively documented i...

  7. Examining indirect effects of lake trout recovery

    Science.gov (United States)

    With the recovery of lake trout populations in Lake Superior, there are indications of decreased forage fish abundance and density-dependence in lake trout. In Lake Superior, lean lake trout historically occupied depths trout occupied depths > 60 m...

  8. Identification of novel targets for miR-29a using miRNA proteomics.

    Directory of Open Access Journals (Sweden)

    Rhishikesh Bargaje

    Full Text Available MicroRNAs (miRNAs are short regulatory RNA molecules that interfere with the expression of target mRNA by binding to complementary sequences. Currently, the most common method for identification of targets of miRNAs is computational prediction based on free energy change calculations, target site accessibility and conservation. Such algorithms predict hundreds of targets for each miRNA, necessitating tedious experimentation to identify the few functional targets. Here we explore the utility of miRNA-proteomics as an approach to identifying functional miRNA targets. We used Stable Isotope Labeling by amino acids in cell culture (SILAC based proteomics to detect differences in protein expression induced by the over-expression of miR-34a and miR-29a. Over-expression of miR-29a, a miRNA expressed in the brain and in cells of the blood lineage, resulted in the differential expression of a set of proteins. Gene Ontology based classification showed that a significant sub-set of these targets, including Voltage Dependent Anion Channel 1 and 2 (VDAC1 and VDAC2 and ATP synthetase, were mitochondrial proteins involved in apoptosis. Using reporter assays, we established that miR-29a targets the 3' Untranslated Regions (3' UTR of VDAC1 and VDAC2. However, due to the limited number of proteins identified using this approach and the inability to differentiate between primary and secondary effects we conclude that miRNA-proteomics is of limited utility as a high-throughput alternative for sensitive and unbiased miRNA target identification. However, this approach was valuable for rapid assessment of the impact of the miRNAs on the cellular proteome and its biological role in apoptosis.

  9. Deregulation of miR-93 and miR-143 in human esophageal cancer.

    Science.gov (United States)

    Ansari, Mohammad Hossein; Irani, Shiva; Edalat, Houri; Amin, Ruhul; Mohammadi Roushandeh, Amaneh

    2016-03-01

    Esophageal squamous cell carcinoma (ESCC) is the second and third most common malignancy in Iranian males and females, respectively. Treatment of ESCC is largely ineffective due to lack of detection at early stages of the disease. In recent years, miRNA, a small RNA molecule, has drawn much attention to researchers as a potential biomarker for esophageal cancer. miR-93 and miR-143 are two miRNA molecules reported to be frequently deregulated in various cancers, including prostate, stomach, cervix, and etc. The purpose of this study was to investigate the expression levels of these miRNAs and evaluate their diagnostic and therapeutic potential in esophageal squamous cell carcinoma. In this study, total RNA was extracted from 30 tumor tissues and 30 nontumor tissues of esophageal tumor margins, using RNX-plus solution. After validating the quality and quantity of total RNA, cDNAs of interest were synthesized using microRNA-specific cDNA Synthesis Kit. The expression level of miR-93 and miR-143 was evaluated using quantitative real-time PCR with miRNA-specific primers. Finally, the obtained data was analyzed by SPSS ver.20 software and paired t test was performed to observe the significance of difference between groups. The expression level of miR-93 was significantly increased and of miR-143 was significantly decreased in most of the examined tumor tissues, compared to nontumor tissues. Also, our findings did not detect correlation between mir-93 and mir-143 expressions in regard to stage and grade of the samples. These findings suggest that the deregulation of these miRNAs may play an important role in esophageal squamous cell carcinoma. Both miR-93 and miR-143 might be used as potential biomarkers in esophageal squamous cell carcinoma. However, more studies with large population of samples are necessary. PMID:26427659

  10. Diagnostic potential of miR-126, miR-143, miR-145, and miR-652 in malignant pleural mesothelioma

    DEFF Research Database (Denmark)

    Andersen, Morten; Grauslund, Morten; Ravn, Jesper;

    2014-01-01

    RNAs in formalin-fixed, paraffin-embedded, preoperative diagnostic biopsy samples, surgically resected MPM specimens previously treated with chemotherapy, and corresponding non-neoplastic pleura (NNP), from five patients. miR-126, miR-143, miR-145, and miR-652 were significantly down-regulated (≥twofold......) in resected MPM and/or chemotherapy-naïve diagnostic tumor biopsy samples. The miRNA expression pattern was validated by RT-qPCR in a cohort of 40 independent MPMs. By performing binary logistic regression on the RT-qPCR data for the four miRNAs, the established four-miRNA classifier differentiated...... MPM from NNP with high sensitivity and specificity (area under the curve, 0.96; 95% CI, 0.92-1.00). The classifier's optimal logit(P) value of 0.62 separated NNP and MPM samples with a sensitivity of 0.95 (95% CI, 0.89-1.00), a specificity of 0.93 (95% CI, 0.87-0.99), and an overall accuracy of 0...

  11. Inference of Gene Regulation via miRNAs During ES Cell Differentiation Using MiRaGE Method

    Directory of Open Access Journals (Sweden)

    Jun Yasuda

    2011-12-01

    Full Text Available MicroRNA (miRNA is a critical regulator of cell growth, differentiation, and development. To identify important miRNAs in a biological process, many bioinformatical tools have been developed. We have developed MiRaGE (MiRNA Ranking by Gene Expression method to infer the regulation of gene expression by miRNAs from changes of gene expression profiles. The method does not require precedent array normalization. We applied the method to elucidate possibly important miRNAs during embryonic stem (ES cell differentiation to neuronal cells and we infer that certain miRNAs, including miR-200 family, miR-429, miR-302 family, and miR-17-92 cluster members may be important to the maintenance of undifferentiated status in ES cells.

  12. MiBoard: Multiplayer Interactive Board Game

    CERN Document Server

    Dempsey, Kyle B; Jackson, G Tanner; Boonthum, Chutima; Levinstein, Irwin B; McNamara, Danielle S

    2010-01-01

    Serious games have recently emerged as an avenue for curriculum delivery. Serious games incorporate motivation and entertainment while providing pointed curriculum for the user. This paper presents a serious game, called MiBoard, currently being developed from the iSTART Intelligent Tutoring System. MiBoard incorporates a multiplayer interaction that iSTART was previously unable to provide. This multiplayer interaction produces a wide variation across game trials, while also increasing the repeat playability for users. This paper presents a demonstration of the MiBoard system and the expectations for its application.

  13. MI high power operation and future plans

    Energy Technology Data Exchange (ETDEWEB)

    Kourbanis, Ioanis; /Fermilab

    2008-09-01

    Fermilab's Main Injector on acceleration cycles to 120 GeV has been running a mixed mode operation delivering beam to both the antiproton source for pbar production and to the NuMI[1] target for neutrino production since 2005. On January 2008 the slip stacking process used to increase the beam to the pbar target was expanded to include the beam to the NuMI target increasing both the beam intensity and power. The current high power MI operation will be described along with the near future plans.

  14. Great Lakes: Great Gardening.

    Science.gov (United States)

    New York Sea Grant Inst., Albany, NY.

    This folder contains 12 fact sheets designed to improve the quality of gardens near the Great Lakes. The titles are: (1) "Your Garden and the Great Lakes"; (2) "Organic Gardening"; (3) "Fruit and Vegetable Gardening"; (4) "Composting Yard Wastes"; (5) "Herbicides and Water Quality"; (6) "Watering"; (7) "Soil Erosion by Water"; (8) "Soil…

  15. Marine lakes of Indonesia

    NARCIS (Netherlands)

    Becking, Leontine Elisabeth

    2012-01-01

    The objective of this thesis was to obtain insight into the processes that play a role in biodiversity patterns of tropical marine species by using marine lakes as a model. Marine lakes are landlocked water bodies that maintain a marine character through narrow submarine connections to the sea. Two

  16. Beautiful Yamzhog Yumco Lake

    Institute of Scientific and Technical Information of China (English)

    SAMXUBAGONJORYUNDAIN

    2003-01-01

    Yamzhog Yumco Lake is one of the three sacred lakes in Tibetan snow area, located in Nangarze County of Shannan Prefecture.Nangarze County is a semi-agricultural and semi-pastoral district, and because the husbandry prioritizes the agriculture,it was named "Yamzhog (meadow landin high mountains)". The Yamzhog

  17. Lake Wobegon Dice

    Science.gov (United States)

    Moraleda, Jorge; Stork, David G.

    2012-01-01

    We introduce Lake Wobegon dice, where each die is "better than the set average." Specifically, these dice have the paradoxical property that on every roll, each die is more likely to roll greater than the set average on the roll, than less than this set average. We also show how to construct minimal optimal Lake Wobegon sets for all "n" [greater…

  18. If You Want to Go Fast Go Alone, If You Want to Go Far Go Together: On Context-Sensitive Group Treatment of Asylum Seekers and Refugees Traumatized by War and Terror

    NARCIS (Netherlands)

    Drozdek, B.

    2014-01-01

    This thesis presents a model for understanding psychological consequences of exposure to war, torture and political violence in asylum seekers and refugees. This contextual, developmental, and culture-sensitive model is based on theoretical and empirical findings and implies framing and interpreting

  19. Mi-DISCOVERER: A bioinformatics tool for the detection of mi-RNA in human genome.

    Science.gov (United States)

    Arshad, Saadia; Mumtaz, Asia; Ahmad, Freed; Liaquat, Sadia; Nadeem, Shahid; Mehboob, Shahid; Afzal, Muhammad

    2010-01-01

    MicroRNAs (miRNAs) are 22 nucleotides non-coding RNAs that play pivotal regulatory roles in diverse organisms including the humans and are difficult to be identified due to lack of either sequence features or robust algorithms to efficiently identify. Therefore, we made a tool that is Mi-Discoverer for the detection of miRNAs in human genome. The tools used for the development of software are Microsoft Office Access 2003, the JDK version 1.6.0, BioJava version 1.0, and the NetBeans IDE version 6.0. All already made miRNAs softwares were web based; so the advantage of our project was to make a desktop facility to the user for sequence alignment search with already identified miRNAs of human genome present in the database. The user can also insert and update the newly discovered human miRNA in the database. Mi-Discoverer, a bioinformatics tool successfully identifies human miRNAs based on multiple sequence alignment searches. It's a non redundant database containing a large collection of publicly available human miRNAs. PMID:21364831

  20. Some MI-Groups%某些MI群

    Institute of Scientific and Technical Information of China (English)

    宋蔷薇; 崔双双

    2011-01-01

    In this paper, We give a complete metacyclic p-groups and extraspecial p-groups. and MA-groups. classification of MI-groups and MA-groups for And we get some other examples of MI-groups%主要分类了亚循环的MI群及MA群,超特殊的MI群及MA群,并给出了一些一般的MI群和MA群的例子.

  1. The NuMI Neutrino Beam

    CERN Document Server

    Adamson, P; Andrews, M; Andrews, R; Anghel, I; Augustine, D; Aurisano, A; Avvakumov, S; Ayres, D S; Baller, B; Barish, B; Barr, G; Barrett, W L; Bernstein, R H; Biggs, J; Bishai, M; Blake, A; Bocean, V; Bock, G J; Boehnlein, D J; Bogert, D; Bourkland, K; Cao, S V; Castromonte, C M; Childress, S; Choudhary, B C; Coelho, J A B; Cobb, J H; Corwin, L; Crane, D; Cravens, J P; Cronin-Hennessy, D; Ducar, R J; de Jong, J K; Devan, A V; Devenish, N E; Diwan, M V; Erwin, A R; Escobar, C O; Evans, J J; Falk, E; Feldman, G J; Fields, T H; Ford, R; Frohne, M V; Gallagher, H R; Garkusha, V; Gomes, R A; Goodman, M C; Gouffon, P; Graf, N; Gran, R; Grossman, N; Grzelak, K; Habig, A; Hahn, S R; Harding, D; Harris, D; Harris, P G; Hartnell, J; Hatcher, R; Hays, S; Heller, K; Holin, A; Huang, J; Hylen, J; Ibrahim, A; Indurthy, D; Irwin, G M; Isvan, Z; Jaffe, D E; James, C; Jensen, D; Johnstone, J; Kafka, T; Kasahara, S M S; Koizumi, G; Kopp, S; Kordosky, M; Kreymer, A; Lang, K; Laughton, C; Lefeuvre, G; Ling, J; Litchfield, P J; Loiacono, L; Lucas, P; Mann, W A; Marchionni, A; Marshak, M L; Mayer, N; McGivern, C; Medeiros, M M; Mehdiyev, R; Meier, J R; Messier, M D; Michael, D G; Milburn, R H; Miller, J L; Miller, W H; Mishra, S R; Sher, S Moed; Moore, C D; Morfin, J; Mualem, L; Mufson, S; Murgia, S; Murtagh, M; Musser, J; Naples, D; Nelson, J K; Newman, H B; Nichol, R J; Nowak, J A; Connor, J O; Oliver, W P; Olsen, M; Orchanian, M; Osprey, S; Pahlka, R B; Paley, J; Para, A; Patterson, R B; Patzak, T; Pavlovic, Z; Pawloski, G; Perch, A; Peterson, E A; Petyt, D A; Pfutzner, M; Phan-Budd, S; Plunkett, R K; Poonthottathil, N; Prieto, P; Pushka, D; Qiu, X; Radovic, A; Rameika, R A; Ratchford, J; Rebel, B; Reilly, R; Rosenfeld, C; Rubin, H A; Ruddick, K; Sanchez, M C; Saoulidou, N; Sauer, L; Schneps, J; Schoo, D; Schreckenberger, A; Schreiner, P; Shanahan, P; Sharma, R; Smart, W; Smith, C; Sousa, A; Stefanik, A; Tagg, N; Talaga, R L; Tassotto, G; Thomas, J; Thompson, J; Thomson, M A; Tian, X; Timmons, A; Tinsley, D; Tognini, S C; Toner, R; Torretta, D; Trostin, I; Tzanakos, G; Urheim, J; Vahle, P; Vaziri, K; Villegas, E; Viren, B; Vogel, G; Webber, R C; Weber, A; Webb, R C; Wehmann, A; White, C; Whitehead, L; Whitehead, L H; Wojcicki, S G; Wong-Squires, M L; Yang, T; Yumiceva, F X; Zarucheisky, V; Zwaska, R

    2015-01-01

    This paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important design details of individual components are described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  2. The NuMI neutrino beam

    Science.gov (United States)

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; Barish, B.; Barr, G.; Barrett, W. L.; Bernstein, R. H.; Biggs, J.; Bishai, M.; Blake, A.; Bocean, V.; Bock, G. J.; Boehnlein, D. J.; Bogert, D.; Bourkland, K.; Cao, S. V.; Castromonte, C. M.; Childress, S.; Choudhary, B. C.; Coelho, J. A. B.; Cobb, J. H.; Corwin, L.; Crane, D.; Cravens, J. P.; Cronin-Hennessy, D.; Ducar, R. J.; De Jong, J. K.; Devan, A. V.; Devenish, N. E.; Diwan, M. V.; Erwin, A. R.; Escobar, C. O.; Evans, J. J.; Falk, E.; Feldman, G. J.; Fields, T. H.; Ford, R.; Frohne, M. V.; Gallagher, H. R.; Garkusha, V.; Gomes, R. A.; Goodman, M. C.; Gouffon, P.; Graf, N.; Gran, R.; Grossman, N.; Grzelak, K.; Habig, A.; Hahn, S. R.; Harding, D.; Harris, D.; Harris, P. G.; Hartnell, J.; Hatcher, R.; Hays, S.; Heller, K.; Holin, A.; Huang, J.; Hylen, J.; Ibrahim, A.; Indurthy, D.; Irwin, G. M.; Isvan, Z.; Jaffe, D. E.; James, C.; Jensen, D.; Johnstone, J.; Kafka, T.; Kasahara, S. M. S.; Koizumi, G.; Kopp, S.; Kordosky, M.; Kreymer, A.; Lang, K.; Laughton, C.; Lefeuvre, G.; Ling, J.; Litchfield, P. J.; Loiacono, L.; Lucas, P.; Mann, W. A.; Marchionni, A.; Marshak, M. L.; Mayer, N.; McGivern, C.; Medeiros, M. M.; Mehdiyev, R.; Meier, J. R.; Messier, M. D.; Michael, D. G.; Milburn, R. H.; Miller, J. L.; Miller, W. H.; Mishra, S. R.; Moed Sher, S.; Moore, C. D.; Morfín, J.; Mualem, L.; Mufson, S.; Murgia, S.; Murtagh, M.; Musser, J.; Naples, D.; Nelson, J. K.; Newman, H. B.; Nichol, R. J.; Nowak, J. A.; O`Connor, J.; Oliver, W. P.; Olsen, M.; Orchanian, M.; Osprey, S.; Pahlka, R. B.; Paley, J.; Para, A.; Patterson, R. B.; Patzak, T.; Pavlović, Ž.; Pawloski, G.; Perch, A.; Peterson, E. A.; Petyt, D. A.; Pfützner, M. M.; Phan-Budd, S.; Plunkett, R. K.; Poonthottathil, N.; Prieto, P.; Pushka, D.; Qiu, X.; Radovic, A.; Rameika, R. A.; Ratchford, J.; Rebel, B.; Reilly, R.; Rosenfeld, C.; Rubin, H. A.; Ruddick, K.; Sanchez, M. C.; Saoulidou, N.; Sauer, L.; Schneps, J.; Schoo, D.; Schreckenberger, A.; Schreiner, P.; Shanahan, P.; Sharma, R.; Smart, W.; Smith, C.; Sousa, A.; Stefanik, A.; Tagg, N.; Talaga, R. L.; Tassotto, G.; Thomas, J.; Thompson, J.; Thomson, M. A.; Tian, X.; Timmons, A.; Tinsley, D.; Tognini, S. C.; Toner, R.; Torretta, D.; Trostin, I.; Tzanakos, G.; Urheim, J.; Vahle, P.; Vaziri, K.; Villegas, E.; Viren, B.; Vogel, G.; Webber, R. C.; Weber, A.; Webb, R. C.; Wehmann, A.; White, C.; Whitehead, L.; Whitehead, L. H.; Wojcicki, S. G.; Wong-Squires, M. L.; Yang, T.; Yumiceva, F. X.; Zarucheisky, V.; Zwaska, R.

    2016-01-01

    This paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important design details of individual components are described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  3. miRNome of inflammatory breast cancer

    OpenAIRE

    Maltseva, Diana V; Galatenko, Vladimir V; Samatov, Timur R.; Zhikrivetskaya, Svetlana O; Khaustova, Nadezhda A; Nechaev, Ilya N; Shkurnikov, Maxim U; Lebedev, Alexey E; Mityakina, Irina A; Kaprin, Andrey D; Schumacher, Udo; Tonevitsky, Alexander G

    2014-01-01

    Background Inflammatory breast cancer (IBC) is an extremely malignant form of breast cancer which can be easily misdiagnosed. Conclusive prognostic IBC molecular biomarkers which are also providing the perspectives for targeted therapy are lacking so far. The aim of this study was to reveal the IBC-specific miRNA expression profile and to evaluate its association with clinicopathological parameters. Methods miRNA expression profiles of 13 IBC and 17 non-IBC patients were characterized using c...

  4. Knock-down of miR-221 and miR-222 in the radiosensitization of breast cancer cells

    International Nuclear Information System (INIS)

    Objective: To investigate the radiosensitizing effect of knock-down of miR-221 miR-222 on MCF-7 human breast cancer cells and explore the possible mechanism. Methods: Antisense oligonucleotides of miR-221 and miR-222 (AS-miR-221 and AS-miR-222), mediated by lipofectamine, were transfected to MCF-7 cells to knock down miR-221 and miR-222, Northern blotting was conducted to detect the expression of miR-221 and miR-222 in transfected cells. The cell apoptosis was detected by flow cytometry and Caspase-3 and Caspase-7 activity assay. Clonogenic assay was used to measure the sensitizing enhancement ratio. Target genes of miR-221 and miR-222 relevant to radio-sensitivity were searched using bioinformatics analysis. The targeted protein expression was determined by Western blot analysis. Results: The expression of miR-221 and miR-222 in the AS-miR-221/222 cells determined by Northern blotting was significantly reduced. Compared with the control group, the cell apoptosis and mitotic cell death after the radiation were significantly higher in AS-miR-221/222 cells. The sensitizing enhancement ratio was 1.87. Based on bioinformatics analysis, PTEN was a target gene of miR-221 and miR-222 which could enhance the radiosensitivity of MCF-7 cells. In AS-miR-221/222 cells, the expression of PTEN was up-regulated while pAkt down-regulated. Conclusions: AS-miR-221 and AS-miR-222 may enhance the radiosensitivity of MCF-7 breast cancer cells by up-regulating the expression of PTEN. (authors)

  5. Lake metabolism scales with lake morphometry and catchment conditions

    DEFF Research Database (Denmark)

    Stæhr, Peter A.; Baastrup-Spohr, Lars; Jensen, Kaj Sand;

    2012-01-01

    We used a comparative data set for 25 lakes in Denmark sampled during summer to explore the influence of lake morphometry, catchment conditions, light availability and nutrient input on lake metabolism. We found that (1) gross primary production (GPP) and community respiration (R) decline with lake...... area, water depth and drainage ratio, and increase with algal biomass (Chl), dissolved organic carbon (DOC) and total phosphorus (TP); (2) all lakes, especially small with less incident light, and forest lakes with high DOC, have negative net ecosystem production (NEP <0); (3) daily variability of GPP...... decreases with lake area and water depth as a consequence of lower input of nutrients and organic matter per unit water volume; (4) the influence of benthic processes on free water metabolic measures declines with increasing lake size; and (5) with increasing lake size, lake metabolism decreases...

  6. MiR genes in myeloma

    International Nuclear Information System (INIS)

    The control of the expression of key genes involved in the progression of Multiple Myeloma (MM). This mechanism of post-transcriptional control introduced a new level of complexity in the analysis of the molecular mechanisms underlying the stabilization of pre-neoplastic events and the neoplastic transformation of normal cell. In this context, the RU focused its attention on the molecular mechanisms potentially involved in MM by using a myeloma cell line as a model (FG.91) versus the peripheral blood mononuclear cells (PBMC) as normal controls. The experimental data collected highlight some critical points. First of all, in FG.91 a defect in miRNA precursor (Pri-miRNA) processing was observed. In fact, in vitro radio-labeled transcribed Pri-miRNA exposed to a total protein extract from FG.91 cells failed to be processed to mature miRNA. Moreover, we established that the processing process was compromised at nuclear level, as demonstrated by the sequential exposure of Pri-miRNA to nuclear and cytoplasmic protein fraction. In particular, FG.91 cells were unable to generate the Pre-miRNA intermediate products

  7. Lake whitefish and lake herring population structure and niche in ten south-central Ontario lakes

    Science.gov (United States)

    Carl, Leon M.; McGuiness, Fiona

    2006-01-01

    This study compares simple fish communities of ten oligotrophic lakes in south-central Ontario. Species densities and population size structure vary significantly among these lake communities depending on fish species present beyond the littoral zone. Lake whitefish are fewer and larger in the presence of lake herring than in their absence. Diet analysis indicates that lake whitefish shift from feeding on both plankton and benthic prey when lake herring are absent to a primarily benthic feeding niche in the presence of lake herring. When benthic round whitefish are present, lake whitefish size and density decline and they move lower in the lake compared to round whitefish. Burbot are also fewer and larger in lakes with lake herring than in lakes without herring. Burbot, in turn, appear to influence the population structure of benthic coregonine species. Lower densities of benthic lake whitefish and round whitefish are found in lakes containing large benthic burbot than in lakes with either small burbot or where burbot are absent. Predation on the pelagic larvae of burbot and lake whitefish by planktivorous lake herring alters the size and age structure of these populations. As life history theory predicts, those species with poor larval survival appear to adopt a bet-hedging life history strategy of long-lived individuals as a reproductive reserve.

  8. Expression of miR-199a, lum and ets2 in benthic and pelagic Arctic charr morphs at developmental stage 200τ

    OpenAIRE

    Ligthart, Kate, 1992-

    2014-01-01

    MiRNAs play an important role in development by regulating gene expression. They are recruited to RISC complexes, which bind to target mRNAs. This interaction causes silencing of the target mRNAs by repressing translation or by initiating degradation. In lake Þingvallavatn there are four morphs of Arctic charr that are very different in morphology and their feeding apparatus. The different morphs of Arctic charr have different levels of miRNA gene expression during their embryonic development...

  9. Discovery pipeline for epigenetically deregulated miRNAs in cancer: integration of primary miRNA transcription

    Directory of Open Access Journals (Sweden)

    Statham Aaron L

    2011-01-01

    Full Text Available Abstract Background Cancer is commonly associated with widespread disruption of DNA methylation, chromatin modification and miRNA expression. In this study, we established a robust discovery pipeline to identify epigenetically deregulated miRNAs in cancer. Results Using an integrative approach that combines primary transcription, genome-wide DNA methylation and H3K9Ac marks with microRNA (miRNA expression, we identified miRNA genes that were epigenetically modified in cancer. We find miR-205, miR-21, and miR-196b to be epigenetically repressed, and miR-615 epigenetically activated in prostate cancer cells. Conclusions We show that detecting changes in primary miRNA transcription levels is a valuable method for detection of local epigenetic modifications that are associated with changes in mature miRNA expression.

  10. Hydrogeologic Controls on Lake Level at Mountain Lake, Virginia

    OpenAIRE

    Roningen, Jeanne Marie

    2011-01-01

    Mountain Lake in Giles County, Virginia, has a documented history of severe natural lake-level changes involving groundwater seepage [Jansons, 2004] that extend over the past 4200 years [Cawley, 1999], and as of December 2010 the lake was about 2% full by volume. Situated in the Valley and Ridge physiographic province on the axis of a plunging anticline and straddling contacts between three upper Ordovician and lower Silurian formations, the lake is one of two natural lakes in Virginia. ...

  11. The ecology of Bassenthwaite Lake (English Lake District)

    OpenAIRE

    Thackeray, Stephen; Maberly, Stephen; Winfield, Ian

    2005-01-01

    Bassenthwaite Lake is, in many ways, different from the other major lakes in the English Lake District: it is the most northerly, the shallowest, has the largest catchment and the shortest mean retention time. There is also considerable temporal variation in lake level. This article summarises the limnological features of Bassenthwaite Lake, the catchment and physical characteristics before describing the water chemistry, phytoplankton, macrophytes, zooplankton, invertebrates, fish, mammal an...

  12. Yellowstone Lake Nanoarchaeota

    Directory of Open Access Journals (Sweden)

    Scott eClingenpeel

    2013-09-01

    Full Text Available Considerable Nanoarchaeota novelty and diversity were encountered in Yellowstone Lake, Yellowstone National Park, where sampling targeted lake floor hydrothermal vent fluids, streamers and sediments associated with these vents, and in planktonic photic zones in three different regions of the lake. Significant homonucleotide repeats (HR were observed in pyrosequence reads and in near full-length Sanger sequences, averaging 112 HR per 1,349 bp clone and could confound diversity estimates derived from pyrosequencing, resulting in false nucleotide insertions or deletions (indels. However, Sanger sequencing of two different sets of PCR clones (110 bp, 1349 bp demonstrated that at least some of these indels are real. The majority of the Nanoarchaeota PCR amplicons were vent associated; however, curiously, one relatively small Nanoarchaeota OTU (70 pyrosequencing reads was only found in photic zone water samples obtained from a region of the lake furthest removed from the hydrothermal regions of the lake. Extensive pyrosequencing failed to demonstrate the presence of an Ignicoccus lineage in this lake, suggesting the Nanoarchaeota in this environment are associated with novel Archaea hosts. Defined phylogroups based on near full-length PCR clones document the significant Nanoarchaeota 16S rRNA gene diversity in this lake and firmly establish a terrestrial clade distinct from the marine Nanoarcheota as well as from other geographical locations.

  13. LAKE RESTORATION BY DILUTION: MOSES LAKE, WASHINGTON

    Science.gov (United States)

    Dilution water, low in macronutrients, was added to Moses Lake on three occasions in 1977 and once in 1978 during the spring-summer period. The addition resulted in reducing the annual average inflow concentration of phosphorus from about 130-140 micrograms/l to 100 micrograms/l....

  14. miR-29b, miR-205 and miR-221 enhance chemosensitivity to gemcitabine in HuH28 human cholangiocarcinoma cells.

    Directory of Open Access Journals (Sweden)

    Kinya Okamoto

    Full Text Available BACKGROUND AND AIMS: Cholangiocarcinoma (CCA is highly resistant to chemotherapy, including gemcitabine (Gem treatment. MicroRNAs (miRNAs are endogenous, non-coding, short RNAs that can regulate multiple genes expression. Some miRNAs play important roles in the chemosensitivity of tumors. Here, we examined the relationship between miRNA expression and the sensitivity of CCA cells to Gem. METHODS: Microarray analysis was used to determine the miRNA expression profiles of two CCA cell lines, HuH28 and HuCCT1. To determine the effect of candidate miRNAs on Gem sensitivity, expression of each candidate miRNA was modified via either transfection of a miRNA mimic or transfection of an anti-oligonucleotide. Ontology-based programs were used to identify potential target genes of candidate miRNAs that were confirmed to affect the Gem sensitivity of CCA cells. RESULTS: HuCCT1 cells were more sensitive to Gem than were HuH28 cells, and 18 miRNAs were differentially expressed whose ratios over ± 2log2 between HuH28 and HuCCT1. Among these 18 miRNAs, ectopic overexpression of each of three downregulated miRNAs in HuH28 (miR-29b, miR-205, miR-221 restored Gem sensitivity to HuH28. Suppression of one upregulated miRNA in HuH28, miR-125a-5p, inhibited HuH28 cell proliferation independently to Gem treatment. Selective siRNA-mediated downregulation of either of two software-predicted targets, PIK3R1 (target of miR-29b and miR-221 or MMP-2 (target of miR-29b, also conferred Gem sensitivity to HuH28. CONCLUSIONS: miRNA expression profiling was used to identify key miRNAs that regulate Gem sensitivity in CCA cells, and software that predicts miRNA targets was used to identify promising target genes for anti-tumor therapies.

  15. Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 loci.

    Directory of Open Access Journals (Sweden)

    Stefano Comazzetto

    2014-10-01

    Full Text Available Male fertility requires the continuous production of high quality motile spermatozoa in abundance. Alterations in all three metrics cause oligoasthenoteratozoospermia, the leading cause of human sub/infertility. Post-mitotic spermatogenesis inclusive of several meiotic stages and spermiogenesis (terminal spermatozoa differentiation are transcriptionally inert, indicating the potential importance for the post-transcriptional microRNA (miRNA gene-silencing pathway therein. We found the expression of miRNA generating enzyme Dicer within spermatogenesis peaks in meiosis with critical functions in spermatogenesis. In an expression screen we identified two miRNA loci of the miR-34 family (miR-34b/c and miR-449 that are specifically and highly expressed in post-mitotic male germ cells. A reduction in several miRNAs inclusive of miR-34b/c in spermatozoa has been causally associated with reduced fertility in humans. We found that deletion of both miR34b/c and miR-449 loci resulted in oligoasthenoteratozoospermia in mice. MiR-34bc/449-deficiency impairs both meiosis and the final stages of spermatozoa maturation. Analysis of miR-34bc-/-;449-/- pachytene spermatocytes revealed a small cohort of genes deregulated that were highly enriched for miR-34 family target genes. Our results identify the miR-34 family as the first functionally important miRNAs for spermatogenesis whose deregulation is causal to oligoasthenoteratozoospermia and infertility.

  16. Role of miR-27a, miR-181a and miR-20b in gastric cancer hypoxia-induced chemoresistance.

    Science.gov (United States)

    Danza, Katia; Silvestris, Nicola; Simone, Giovanni; Signorile, Michele; Saragoni, Luca; Brunetti, Oronzo; Monti, Manlio; Mazzotta, Annalisa; De Summa, Simona; Mangia, Anita; Tommasi, Stefania

    2016-04-01

    Despite the search for new therapeutic strategies for gastric cancer (GC), there is much evidence of progression due to resistance to chemotherapy. Multidrug resistance (MDR) is the ability of cancer cells to survive after exposure to chemotherapeutic agents. The involvement of miRNAs in the development of MDR has been well described but miRNAs able to modulate the sensitivity to chemotherapy by regulating hypoxia signaling pathways have not yet been fully addressed in GC. Our aim was to analyze miR-20b, miR-27a and miR-181a expression with respect to (epirubicin/oxaliplatin/capecitabine (EOX)) chemotherapy regimen in a set of GC patients, in order to investigate whether miRNAs deregulation may influence GC MDR also via hypoxia signaling modulation. Cancer biopsy were obtained from 21 untreated HER2 negative advanced GC patients, retrospectively analyzed. All patients received a first-line chemotherapy (EOX) regimen. MirWalk database was used to identify miR-27a, miR-181a and miR-20b target genes. The expression of miRNAs and of HIPK2, HIF1A and MDR1 genes were detected by real-time PCR. HIPK2 localization was assessed by immunohistochemistry. Our data showed the down-regulation of miR-20b, miR-27a, miR-181a concomitantly to higher levels of MDR1, HIF1A and HIPK2 genes in GC patients with a progressive disease respect to those with a disease control rate. Moreover, immunohistochemistry assay highlighted a higher cytoplasmic HIPK2 staining, suggesting a different role for it. We showed that aberrant expression of miR-20b, miR27a and miR-181a was associated with chemotherapeutic response in GC through HIF1A, MDR1 and HIPK2 genes modulation, suggesting a possible novel therapeutic strategy. PMID:26793992

  17. A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas

    Science.gov (United States)

    Ng, Kimberly; Steed, Tyler; Nguyen, Thien; Futalan, Diahnn; Akers, Johnny C.; Sarkaria, Jann; Jiang, Tao; Chowdhury, Dipanjan; Carter, Bob S.; Chen, Clark C.

    2014-01-01

    MGMT expression is a critical determinant for therapeutic resistance to DNA alkylating agents. We previously demonstrated that MGMT expression is post-transcriptionally regulated by miR-181d and other miRNAs. Here, we performed a genome-wide screen to identify MGMT regulating miRNAs. Candidate miRNAs were further tested for inverse correlation with MGMT expression in clinical specimens. We identified 15 candidate miRNAs and characterized the top candidate, miR-603. Transfection of miR-603 suppressed MGMT mRNA/protein expression in vitro and in vivo; this effect was reversed by transfection with antimiR-603. miR-603 affinity-precipitated with MGMT mRNA and suppressed luciferase activity in an MGMT-3'UTR-luciferase assay, suggesting direct interaction between miR-603 and MGMT 3'UTR. miR-603 transfection enhanced the temozolomide (TMZ) sensitivity of MGMT-expressing glioblastoma cell lines. Importantly, miR-603 mediated MGMT suppression and TMZ resistance were reversed by expression of an MGMT cDNA. In a collection of 74 clinical glioblastoma specimens, both miR-603 and miR-181d levels inversely correlated with MGMT expression. Moreover, a combined index of the two miRNAs better reflected MGMT expression than each individually. These results suggest that MGMT is co-regulated by independent miRNAs. Characterization of these miRNAs should contribute toward strategies for enhancing the efficacy of DNA alkylating agents. PMID:24994119

  18. Valuing Great Lakes Beaches

    OpenAIRE

    Song, Feng; Lupi, Frank; Kaplowitz, Michael D.

    2010-01-01

    This study aims to estimate the recreational use values of Great Lakes beaches using a two-level nested logit Random Utility Model. The choice set contains all 594 public Great Lakes beaches in Michigan. Beach sites located in the same Great Lakes water body are arranged into a nest. The trip data were obtained from a 2006 online survey using a web-panel of Michigan adults accessed through Survey Sampling International (SSI). The variables that affect the amount of utility derived from a part...

  19. Impact of host genes and strand selection on miRNA and miRNA* expression.

    Directory of Open Access Journals (Sweden)

    Marta Biasiolo

    Full Text Available Dysregulation of miRNAs expression plays a critical role in the pathogenesis of genetic, multifactorial disorders and in human cancers. We exploited sequence, genomic and expression information to investigate two main aspects of post-transcriptional regulation in miRNA biogenesis, namely strand selection regulation and expression relationships between intragenic miRNAs and host genes. We considered miRNAs expression profiles, measured in five sizeable microarray datasets, including samples from different normal cell types and tissues, as well as different tumours and disease states. First, the study of expression profiles of "sister" miRNA pairs (miRNA/miRNA*, 5' and 3' strands of the same hairpin precursor showed that the strand selection is highly regulated since it shows tissue-/cell-/condition-specific modulation. We used information about the direction and the strength of the strand selection bias to perform an unsupervised cluster analysis for the sample classification evidencing that is able to distinguish among different tissues, and sometimes between normal and malignant cells. Then, considering a minimum expression threshold, in few miRNA pairs only one mature miRNA is always present in all considered cell types, whereas the majority of pairs were concurrently expressed in some cell types and alternatively in others. In a significant fraction of concurrently expressed pairs, the major and the minor forms found at comparable levels may contribute to post-transcriptional gene silencing, possibly in a coordinate way. In the second part of the study, the behaved tendency to co-expression of intragenic miRNAs and their "host" mRNA genes was confuted by expression profiles examination, suggesting that the expression profile of a given host gene can hardly be a good estimator of co-transcribed miRNA(s for post-transcriptional regulatory networks inference. Our results point out the regulatory importance of post-transcriptional phases of mi

  20. miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis

    DEFF Research Database (Denmark)

    Coskun, Mehmet; Bjerrum, Jacob Tveiten; Seidelin, Jakob Benedict;

    2013-01-01

    were obtained endoscopically from patients with active UC or CD, quiescent UC or CD, as well as healthy controls. Total RNA was isolated and miRNA expression assessed using the miRNA microarray Geniom Biochip miRNA Homo sapiens (Febit GmbH, Heidelberg, Germany). Data analysis was carried out by...

  1. Discovery of miRNAs and Their Corresponding miRNA Genes in Atlantic Cod (Gadus morhua): Use of Stable miRNAs as Reference Genes Reveals Subgroups of miRNAs That Are Highly Expressed in Particular Organs

    Science.gov (United States)

    Andreassen, Rune; Rangnes, Fredrik; Sivertsen, Maria; Chiang, Michelle; Tran, Michelle; Worren, Merete Molton

    2016-01-01

    Background Atlantic cod (Gadus morhua) is among the economically most important species in the northern Atlantic Ocean and a model species for studying development of the immune system in vertebrates. MicroRNAs (miRNAs) are an abundant class of small RNA molecules that regulate fundamental biological processes at the post-transcriptional level. Detailed knowledge about a species miRNA repertoire is necessary to study how the miRNA transcriptome modulate gene expression. We have therefore discovered and characterized mature miRNAs and their corresponding miRNA genes in Atlantic cod. We have also performed a validation study to identify suitable reference genes for RT-qPCR analysis of miRNA expression in Atlantic cod. Finally, we utilized the newly characterized miRNA repertoire and the dedicated RT-qPCR method to reveal miRNAs that are highly expressed in certain organs. Results The discovery analysis revealed 490 mature miRNAs (401 unique sequences) along with precursor sequences and genomic location of the miRNA genes. Twenty six of these were novel miRNA genes. Validation studies ranked gmo-miR-17-1—5p or the two-gene combination gmo-miR25-3p and gmo-miR210-5p as most suitable qPCR reference genes. Analysis by RT-qPCR revealed 45 miRNAs with significantly higher expression in tissues from one or a few organs. Comparisons to other vertebrates indicate that some of these miRNAs may regulate processes like growth, lipid metabolism, immune response to microbial infections and scar damage repair. Three teleost-specific and three novel Atlantic cod miRNAs were among the differentially expressed miRNAs. Conclusions The number of known mature miRNAs was considerably increased by our identification of miRNAs and miRNA genes in Atlantic cod. This will benefit further functional studies of miRNA expression using deep sequencing methods. The validation study showed that stable miRNAs are suitable reference genes for RT-qPCR analysis of miRNA expression. Applying RT-qPCR we

  2. MDRL lncRNA regulates the processing of miR-484 primary transcript by targeting miR-361.

    Directory of Open Access Journals (Sweden)

    Kun Wang

    2014-07-01

    Full Text Available Long noncoding RNAs (lncRNAs are emerging as new players in gene regulation, but whether lncRNAs operate in the processing of miRNA primary transcript is unclear. Also, whether lncRNAs are involved in the regulation of the mitochondrial network remains to be elucidated. Here, we report that a long noncoding RNA, named mitochondrial dynamic related lncRNA (MDRL, affects the processing of miR-484 primary transcript in nucleus and regulates the mitochondrial network by targeting miR-361 and miR-484. The results showed that miR-361 that predominantly located in nucleus can directly bind to primary transcript of miR-484 (pri-miR-484 and prevent its processing by Drosha into pre-miR-484. miR-361 is able to regulate mitochondrial fission and apoptosis by regulating miR-484 levels. In exploring the underlying molecular mechanism by which miR-361 is regulated, we identified MDRL and demonstrated that it could directly bind to miR-361 and downregulate its expression levels, which promotes the processing of pri-miR-484. MDRL inhibits mitochondrial fission and apoptosis by downregulating miR-361, which in turn relieves inhibition of miR-484 processing by miR-361. Our present study reveals a novel regulating model of mitochondrial fission program which is composed of MDRL, miR-361 and miR-484. Our work not only expands the function of the lncRNA pathway in gene regulation but also establishes a new mechanism for controlling miRNA expression.

  3. MI Gap Clearing Kicker Magnet Design Review

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Chris; /Fermilab

    2008-10-01

    The kicker system requirements were originally conceived for the NOvA project. NOvA is a neutrino experiment located in Minnesota. To achieve the desired neutrino flux several upgrades are required to the accelerator complex. The Recycler will be used as a proton pre-injector for the Main Injector (MI). As the Recycler is the same size as the MI, it is possible to do a single turn fill ({approx}11 {micro}sec), minimizing the proton injection time in the MI cycle and maximizing the protons on target. The Recycler can then be filled with beam while the MI is ramping to extract beam to the target. To do this requires two new transfer lines. The existing Recycler injection line was designed for 10{pi} pbar beams, not the 20{pi} proton beams we anticipate from the Booster. The existing Recycler extraction line allows for proton injection through the MI, while we want direct injection from the Booster. These two lines will be decommissioned. The new injection line from the MI8 line into the Recycler will start at 848 and end with injection kickers at RR104. The new extraction line in the RR30 straight section will start with a new extraction kicker at RR232 and end with new MI injection kickers at MI308. Finally, to reduce beam loss activation in the enclosure, a new gap clearing kicker will be used to extract uncaptured beam created during the slip stack injection process down the existing dump line. It was suggested that the MI could benefit from this type of system immediately. This led to the early installation of the gap clearing system in the MI, followed by moving the system to Recycler during NOvA. The specifications also changed during this process. Initially the rise and fall time requirements were 38 ns and the field stability was {+-}1%. The 38 ns is based on having a gap of 2 RF buckets between injections. (There are 84 RF buckets that can be filled from the Booster for each injection, but 82 would be filled with beam. MI and Recycler contain 588 RF buckets

  4. Characterization of the Merkel Cell Carcinoma miRNome

    Directory of Open Access Journals (Sweden)

    Matthew S. Ning

    2014-01-01

    Full Text Available MicroRNAs have been implicated in various skin cancers, including melanoma, squamous cell carcinoma, and basal cell carcinoma; however, the expression of microRNAs and their role in Merkel cell carcinoma (MCC have yet to be explored in depth. To identify microRNAs specific to MCC (MCC-miRs, next-generation sequencing (NGS of small RNA libraries was performed on different tissue samples including MCCs, other cutaneous tumors, and normal skin. Comparison of the profiles identified several microRNAs upregulated and downregulated in MCC. For validation, their expression was measured via qRT-PCR in a larger group of MCC and in a comparison group of non-MCC cutaneous tumors and normal skin. Eight microRNAs were upregulated in MCC: miR-502-3p, miR-9, miR-7, miR-340, miR-182, miR-190b, miR-873, and miR-183. Three microRNAs were downregulated: miR-3170, miR-125b, and miR-374c. Many of these MCC-miRs, the miR-183/182/96a cistron in particular, have connections to tumorigenic pathways implicated in MCC pathogenesis. In situ hybridization confirmed that the highly expressed MCC-miR, miR-182, is localized within tumor cells. Furthermore, NGS and qRT-PCR reveal that several of these MCC-miRs are highly expressed in the patient-derived MCC cell line, MS-1. These data indicate that we have identified a set of MCC-miRs with important implications for MCC research.

  5. tRFs: miRNAs in disguise.

    Science.gov (United States)

    Venkatesh, Thejaswini; Suresh, Padmanaban S; Tsutsumi, Rie

    2016-04-01

    tRFs and tiRNAs are two new classes of regulatory non-coding small RNAs that are derived from the cleavage of pre-existing tRNAs. tRFs are 18-22 nt long and are classified into the tRF-5, tRF-3, and tRF-1 series. Here, we discuss in detail the regulatory roles of tRFs in translation, viral infections, and carcinogenesis. Moreover, we have reviewed the association of tRFs with Argonaute proteins, including their potential to function as miRNAs. Interestingly, few miRNAs are generated from pre-existing tRNAs. Hence, tRNAs generate similar-sized tRFs and miRNAs, leading to misannotations due to cross mapping of tRFs and tRNA-derived miRNAs during deep sequencing data analysis. Therefore, it is important to catalogue the overlapping sequences between tRNA-derived miRNAs and tRFs. We have catalogued the miRNAs that overlap with tRFs sequences in humans using miRBase. We identified 20 tRNA-derived miRNAs that share sequences with tRFs. Of the 20 miRNAs, 5 miRNAs (miR-3182, miR-4521, miR-1260a, miR-1260b, and miR-7977) showed significant prediction scores. Furthermore, we have identified a lysine degradation pathway as a common regulatory pathway for miR-1260a, miR-1260b, and miR-3182 by using DIANA-mirPath. PMID:26743126

  6. Great Lakes Ice Charts

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Charts show ice extent and concentration three times weekly during the ice season, for all lakes except Ontario, from the 1973/74 ice season through the 2001/2002...

  7. Lake Transect : 1986

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document summarizes transect surveys that were done at four different lakes on St. Vincent National Wildlife Refuge in 1986. Lists of the plant species found...

  8. Lake Transect : 1988

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document summarizes transect surveys that were done at four different lakes on St. Vincent National Wildlife Refuge in 1988. Lists of the plant species found...

  9. Lake Transect : 1987

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document summarizes transect surveys that were done at four different lakes on St. Vincent National Wildlife Refuge in 1987. Lists of the plant species found...

  10. Lake Transect : 1990

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document summarizes transect surveys that were done at four different lakes on St. Vincent National Wildlife Refuge in 1990. Lists of the plant species found...

  11. Lake Transect : 1989

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document summarizes transect surveys that were done at four different lakes on St. Vincent National Wildlife Refuge in 1989. Lists of the plant species found...

  12. Lake Mason trip report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a summary of the August 31, 1998 trip to Lake Mason to review the hydrology, current conditions, habitat and wildlife. This site visit occurred due...

  13. History of Lake Andes

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Information about the history and management of Lake Andes is compiled in this report. It is intended to help future refuge managers become acquainted with the...

  14. Lake Level Reconstructions

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Records of past lake levels, mostly related to changes in moisture balance (evaporation-precipitation). Parameter keywords describe what was measured in this data...

  15. Halls Lake 1990

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Salt marsh habitats along the shoreline of Halls Lake are threatened by wave erosion, but the reconstruction of barrier islands to reduce this erosion will modify...

  16. Analyzing MiRNA-LncRNA Interactions.

    Science.gov (United States)

    Paraskevopoulou, Maria D; Hatzigeorgiou, Artemis G

    2016-01-01

    Long noncoding RNAs (lncRNAs) are noncoding transcripts usually longer than 200 nts that have recently emerged as one of the largest and significantly diverse RNA families. The biological role and functions of lncRNAs are still mostly uncharacterized. Their target-mimetic, sponge/decoy function on microRNAs was recently uncovered. miRNAs are a class of noncoding RNA species (~22 nts) that play a central role in posttranscriptional regulation of protein coding genes by mRNA cleavage, direct translational repression and/or mRNA destabilization. LncRNAs can act as miRNA sponges, reducing their regulatory effect on mRNAs. This function introduces an extra layer of complexity in the miRNA-target interaction network. This chapter focuses on the study of miRNA-lncRNA interactions with either in silico or experimentally supported analyses. The proposed methodologies can be appropriately adapted in order to become the backbone of advanced multistep functional miRNA analyses. PMID:26721498

  17. The Importance of Resources and Security in the Socio-Economic Integration of Refugees. A Study on the Impact of Length of Stay in Asylum Accommodation and Residence Status on Socio-Economic Integration for the Four Largest Refugee Groups in the Netherlands

    OpenAIRE

    Bakker, Linda; Dagevos, Jaco; Engbersen, Godfried

    2013-01-01

    textabstractIn many European countries, including the Netherlands, refugees stay in asylum accommodation pending a decision on their asylum request. While it seems evident that the lack of resources and insecurity about the future experienced during this stay will impact refugees' subsequent ability to integrate with the host society, so far this has hardly been studied in an extensive way. Also, the type of residence status granted can be a source of insecurity that impacts their integration...

  18. Chase Lake Wetland Management District, Chase Lake National Wildlife Refuge, Chase Lake Prairie Project: Annual narrative report: 1997

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Chase Lake WMD, Chase Lake NWR, Chase Lake Prairie Project, and Halfway Lake NWR outlines Refuge accomplishments during the 1997...

  19. Archaea in Yellowstone Lake

    OpenAIRE

    Kan, Jinjun; Clingenpeel, Scott; Macur, Richard E.; Inskeep, William P.; Lovalvo, Dave; Varley, John; Gorby, Yuri; McDermott, Timothy R.; Nealson, Kenneth

    2011-01-01

    The Yellowstone geothermal complex has yielded foundational discoveries that have significantly enhanced our understanding of the Archaea. This study continues on this theme, examining Yellowstone Lake and its lake floor hydrothermal vents. Significant Archaea novelty and diversity were found associated with two near-surface photic zone environments and two vents that varied in their depth, temperature and geochemical profile. Phylogenetic diversity was assessed using 454-FLX sequencing (∼51 ...

  20. Integrated Lake Management Project

    OpenAIRE

    Goverment of Uganda; Department for International Development (DFID) of the UK Government

    2007-01-01

    In 1999, the Integrated Co-management of Lakes through Beach Management Units project was started in an effort to implement a new approach to the management of lake resources in Uganda. The main components of this plan involved decentralization, local community management, and improving the livelihood of the poor. In order to finance the management of these areas, the Beach Management Units (BMU's) are charging user fees to those individuals who obtain benefit from the natural resources. Thes...

  1. Phytoplankton of Lake Kivu

    OpenAIRE

    Sarmento, Hugo; Darchambeau, François; Descy, Jean-Pierre

    2012-01-01

    This chapter reviews taxonomic composition, biomass, production and nutrient limitation of the phytoplankton of Lake Kivu. Present Lake Kivu phytoplankton is dominated by cyanobacteria – mainly Synechococcus spp. and thin filaments of Planktolyngbya limnetica – and by pennate diatoms, among which Nitzschia bacata and Fragilaria danica are dominant. Seasonal shifts occur, with cyanobacteria developing more in the rainy season, and the diatoms in the dry season. Other groups present are cryptop...

  2. AAV-mediated miRNA Delivery and Therapeutics

    OpenAIRE

    Xie, Jun; Burt, Daniel Robert; Gao, Guangping

    2015-01-01

    MicroRNAs are 20-24 nt long, single-stranded RNAs that repress gene expression. Dysregulation of miRNA expression is associated with many human diseases. Modulating the level of endogenous miRNA alters gene profiling and can achieve therapeutic benefits. Here, we reviewed currently used methods of altering miRNA activity in vivo. We focus on the delivery of miRNAs and miRNA inhibitors using recombinant adeno-associated virus (rAAV). In general, rAAV-mediated miRNA inhibition or overexpression...

  3. The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer

    Directory of Open Access Journals (Sweden)

    Jia Yu

    2013-07-01

    Full Text Available The discovery of microRNAs (miRNAs provides a new and powerful tool for studying the mechanism, diagnosis and treatment of human cancers. Currently, the methylation epigenetic silencing of miRNAs with tumor suppressor features by CpG island hypermethylation is emerging as a common hallmark of different tumors. Here we showed that miR-433 and miR-127 were significantly down-regulated in gastric cancer (GC tissues compared with the adjacent normal regions in 86 paired samples. Moreover, the lower level of miR-433 and miR-127 was associated with pM or pTNM stage in clinical gastric cancer patients. The restored expression of miR-433 and miR-127 in GC cells upon 5-Aza-CdR and TSA treatment suggested the loss of miR-433 and miR-127 was at least partly regulated by epigenetic modification in GC. Furthermore, the ectopic expression of miR-433 and miR-127 in gastric cancer cell lines HGC-27 inhibits cell proliferation, cell cycle progression, cell migration and invasion by directly interacting with the mRNA encoding oncogenic factors KRAS and MAPK4 respectively. Taken together, our results showed that miR-433 and miR-127 might act as tumor suppressors in GC, and it may provide novel diagnostic and therapeutic options for human GC clinical operation in the near future.

  4. Resilience and Restoration of Lakes

    Directory of Open Access Journals (Sweden)

    Kathryn L. Cottingham

    1997-06-01

    Full Text Available Lake water quality and ecosystem services are normally maintained by several feedbacks. Among these are nutrient retention and humic production by wetlands, nutrient retention and woody habitat production by riparian forests, food web structures that cha nnel phosphorus to consumers rather than phytoplankton, and biogeochemical mechanisms that inhibit phosphorus recycling from sediments. In degraded lakes, these resilience mechanisms are replaced by new ones that connect lakes to larger, regional economi c and social systems. New controls that maintain degraded lakes include runoff from agricultural and urban areas, absence of wetlands and riparian forests, and changes in lake food webs and biogeochemistry that channel phosphorus to blooms of nuisance al gae. Economic analyses show that degraded lakes are significantly less valuable than normal lakes. Because of this difference in value, the economic benefits of restoring lakes could be used to create incentives for lake restoration.

  5. "Seed-Milarity" confers to hsa-miR-210 and hsa-miR-147b similar functional activity.

    Directory of Open Access Journals (Sweden)

    Thomas Bertero

    Full Text Available Specificity of interaction between a microRNA (miRNA and its targets crucially depends on the seed region located in its 5'-end. It is often implicitly considered that two miRNAs sharing the same biological activity should display similarity beyond the strict six nucleotide region that forms the seed, in order to form specific complexes with the same mRNA targets. We have found that expression of hsa-miR-147b and hsa-miR-210, though triggered by different stimuli (i.e. lipopolysaccharides and hypoxia, respectively, induce very similar cellular effects in term of proliferation, migration and apoptosis. Hsa-miR-147b only shares a "minimal" 6-nucleotides seed sequence with hsa-miR-210, but is identical with hsa-miR-147a over 20 nucleotides, except for one base located in the seed region. Phenotypic changes induced after heterologous expression of miR-147a strikingly differ from those induced by miR-147b or miR-210. In particular, miR-147a behaves as a potent inhibitor of cell proliferation and migration. These data fit well with the gene expression profiles observed for miR-147b and miR-210, which are very similar, and the gene expression profile of miR-147a, which is distinct from the two others. Bioinformatics analysis of all human miRNA sequences indicates multiple cases of miRNAs from distinct families exhibiting the same kind of similarity that would need to be further characterized in terms of putative functional redundancy. Besides, it implies that functional impact of some miRNAs can be masked by robust expression of miRNAs belonging to distinct families.

  6. miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer.

    Science.gov (United States)

    Letelier, Pablo; García, Patricia; Leal, Pamela; Álvarez, Héctor; Ili, Carmen; López, Jaime; Castillo, Jonathan; Brebi, Priscilla; Roa, Juan Carlos

    2014-01-01

    The development of miRNA-based therapeutics represents a new strategy in cancer treatment. The objectives of this study were to evaluate the differential expression of microRNAs in gallbladder cancer (GBC) and to assess the functional role of miR-1 and miR-145 in GBC cell behavior. A profile of miRNA expression was determined using DharmaconTM microarray technology. Differential expression of five microRNAs was validated by TaqMan reverse transcription quantitative-PCR in a separate cohort of 8 tumors and 3 non-cancerous samples. Then, we explored the functional role of miR-1 and miR-145 in tumor cell behavior by ectopic in vitro expression in the GBC NOZ cell line. Several miRNAs were found to be aberrantly expressed in GBC; most of these showed a significantly decreased expression compared to non-neoplastic tissues (Q valueanalysis revealed that the most deregulated miRNAs (miR-1, miR-133, miR-143 and miR-145) collectively targeted a number of genes belonging to signaling pathways such as TGF-β, ErbB3, WNT and VEGF, and those regulating cell motility or adhesion. The ectopic expression of miR-1 and miR-145 in NOZ cells significantly inhibited cell viability and colony formation (P<0.01) and reduced gene expression of VEGF-A and AXL. This study represents the first investigation of the miRNA expression profile in gallbladder cancer, and our findings showed that several miRNAs are deregulated in this neoplasm. In vitro functional assays suggest that miR-1 and miR-145 act as tumor suppressor microRNAs in GBC. PMID:24966896

  7. Is Lake Chabot Eutrophic?

    Science.gov (United States)

    Pellegrini, K.; Logan, J.; Esterlis, P.; Lew, A.; Nguyen, M.

    2013-12-01

    Introduction/Abstract: Lake Chabot is an integral part of the East Bay watershed that provides habitats for animals and recreation for humans year-round. Lake Chabot has been in danger of eutrophication due to excessive dumping of phosphorous and nitrogen into the water from the fertilizers of nearby golf courses and neighboring houses. If the lake turned out to be eutrophified, it could seriously impact what is currently the standby emergency water supply for many Castro Valley residents. Eutrophication is the excessive richness of nutrients such as nitrogen and phosphorus in a lake, usually as a result of runoff. This buildup of nutrients causes algal blooms. The algae uses up most of the oxygen in the water, and when it dies, it causes the lake to hypoxify. The fish in the lake can't breathe, and consequently suffocate. Other oxygen-dependant aquatic creatures die off as well. Needless to say, the eutrophication of a lake is bad news for the wildlife that lives in or around it. The level of eutrophication in our area in Northern California tends to increase during the late spring/early summer months, so our crew went out and took samples of Lake Chabot on June 2. We focused on the area of the lake where the water enters, known on the map as Honker Bay. We also took readings a ways down in deeper water for comparison's sake. Visually, the lake looked in bad shape. The water was a murky green that glimmered with particulate matter that swirled around the boat as we went by. In the Honker Bay region where we focused our testing, there were reeds bathed in algae that coated the surface of the lake in thick, swirling patterns. Surprisingly enough, however, our test results didn't reveal any extreme levels of phosphorous or nitrogen. They were slightly higher than usual, but not by any significant amount. The levels we found were high enough to stimulate plant and algae growth and promote eutrophication, but not enough to do any severe damage. After a briefing with a

  8. “The way the Irish asylum system turns people into un-human is my problem”: An Interview with Ifedinma Dimbo

    Directory of Open Access Journals (Sweden)

    Sara Martín-Ruiz

    2015-03-01

    Ifedinma Dimbo currently lives in Dublin, where she works and researches for her PhD in Medical Sociology. The Nigerian-born, Irish-based writer was kind enough to answer my questions via e-mail between the months of August and October 2014, with some final elaboration in January 2015. Ifedinma Dimbo’s writing, as well as her answers in this interview, are an invaluable testimony to a reality that is currently taking place in Ireland and has often been silenced. Now that Irish society is beginning to be aware of the unfair treatment that refugees and asylum seekers receive at the hands of the Irish system, it is high time to let people who, like Ifedinma Dimbo, have made Ireland their home, have their voices heard in the field of Irish Studies. In this interview, Ifedinma Dimbo very sharply shares her views on writing, immigration, religion and Irish society.

  9. Geographical distribution of torture: An epidemiological study of torture reported by asylum applicants examined at the Department of Forensic Medicine, University of Copenhagen

    DEFF Research Database (Denmark)

    Busch, Johannes Rødbro; Hansen, Steen Holger; Hougen, Hans Petter

    2015-01-01

    Using reports from 154 examinations of alleged torture victims among asylum applicants to Denmark conducted by the Department of Forensic Medicine, Univer- sity of Copenhagen, between 2001 and 2013, we have categorized the victims into four geographical regions, as well as according to the conflict...... that caused them to flee. The torture incidents described by the victims were divided into 12 different categories defined by the Istanbul Protocol. These data were cross referenced in order to identify any differences in the prevalence of the 12 forms of torture. The study showed that crush injuries...... were only reported by refugees from Asia, including Afghanistan and Pakistan, and that incidents of electrical torture were reported twice as frequently by torture victims from Middle Eastern and North African countries, though it was lower  among Iraqis, Iranians and ethnic Kurds. Sexual torture was...

  10. Geographical distribution of torture: An epidemiological study of torture reported by asylum applicants examined at the Department of Forensic Medicine, University of Copenhagen.

    Science.gov (United States)

    Busch, J; Hansen, S H; Hougen, H P

    2015-01-01

    Using reports from 154 examinations of alleged torture victims among asylum applicants to Denmark conducted by the Department of Forensic Medicine, University of Copenhagen, between 2001 and 2013, we have categorized the victims into four geographical regions, as well as according to the conflict that caused them to flee. The torture incidents described by the victims were divided into 12 different categories defined by the Istanbul Protocol. These data were cross referenced in order to identify any differences in the prevalence of the 12 forms of torture. The study showed that crush injuries were only reported by refugees from Asia, including Afghanistan and Pakistan, and that incidents of electrical torture were reported twice as frequently by torture victims from Middle Eastern and North African countries, though it was lower among Iraqis, Iranians and ethnic Kurds. Sexual torture was reported by 78% of females and 25% of males. PMID:26932127

  11. [Power and everyday life in a lunatic asylum environment - a case example from Glasgow at the beginning of the 20th century].

    Science.gov (United States)

    Gründler, Jens

    In this article the focus of analysis lies on power relations in everyday life in one of Glasgow's Pauper Lunatic Asylums at the turn of the twentieth century. Taking a sample of patient case files I examine the daily processes of negotiation between inmates and their relatives, physicians, attendants and nurses as well as the poor law administration. Some cases especially exemplify the complex relationships between the actors. They show which opportunities and boundaries existed for "power brokering" for the more powerless. At the same time these cases illustrate the formal and practical limits of enforcement by doctors and nursing staff. Without turning a blind eve to hierarchies and power imbalances the analysis shows that even in settings like "total institutions" power remains volatile. Even there the more powerful actors have to actualize, seize and prevail on a regular basis. PMID:27501547

  12. Perchlorate in The Great Lakes: Distribution, Isotopic Composition and Origin

    Science.gov (United States)

    Poghosyan, A.; Sturchio, N. C.; Jackson, W. A.; Guan, Y.; Eiler, J. M.; Hatzinger, P. B.

    2013-12-01

    Concentrations, stable chlorine and oxygen isotopic compositions, and 36Cl abundances of perchlorate were investigated in the five Laurentian Great Lakes. Samples were collected during monitoring cruises in 2007 and 2008 of the U.S. EPA's RV Lake Guardian and in 2010 at the water supply intake of Marquette, MI on the southern shore of Lake Superior. Concentrations of perchlorate were measured by IC/MS/MS at 24 locations, including one or two depth profiles in each lake. Mean concentrations (μg/L) are: Superior, 0.06 × 0.01; Michigan, 0.10 × 0.01; Huron, 0.11 × 0.01; Erie, 0.08 × 0.01, and Ontario, 0.09 × 0.01. Concentration vs. depth is nearly constant in each lake, indicating well-mixed conditions. Perchlorate was extracted from near-surface water by passing 15,000 to 80,000 L of water through 1-L cartridges containing Purolite A530E bifunctional anion-exchange resin. In the laboratory, perchlorate was eluted from the resin, purified, and precipitated as a >99% pure crystalline phase. Milligram amounts were recovered from each lake. Chlorine and oxygen isotopic analyses were performed at Caltech using the Cameca 7f-GEO SIMS instrument, following validation of the SIMS method with analyses of USGS-37 and USGS-38 isotopic reference materials. Results indicate a relatively narrow range in δ37Cl values (+2.9 to +3.9 ‰) and a wider range in δ18O values (-4.0 to +4.1 ‰), with a general geographic trend of increasing δ18O from west to east. Oxygen-17 was measured at UIC using dual-inlet IRMS of O2 produced by decomposition of KClO4. Great Lakes perchlorate has mass-independent oxygen isotopic variations with positive Δ17O values (+1.6 ‰ to +2.7 ‰) divided into two distinct groups: Lake Superior (+2.7 ‰) and the other four lakes (~ +1.7 ‰). The isotopic data indicate that perchlorate is dominantly of natural origin, having stable isotopic compositions resembling those of perchlorate from pre-industrial groundwaters in the western USA. The 36Cl

  13. Tewaukon – Clouds LakeLake Elsie – Storm Lake and Wild Rice Refuges Narrative Reports : 1939-1956 : From Sand Lake National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — These narrative reports summarize refuge activities from 1939 to 1956 for Lake Tewaukon Refuge, Clouds Lake Refuge, Lake Elsie Refuge, Storm Lake Refuge, Wild Rice...

  14. miRNA expression during prickly pear cactus fruit development.

    Science.gov (United States)

    Rosas-Cárdenas, Flor de Fátima; Caballero-Pérez, Juan; Gutiérrez-Ramos, Ximena; Marsch-Martínez, Nayelli; Cruz-Hernández, Andrés; de Folter, Stefan

    2015-02-01

    miRNAs are a class of small non-coding RNAs that regulate gene expression. They are involved in the control of many developmental processes, including fruit development. The increasing amount of information on miRNAs, on their expression, abundance, and conservation between various species, provides a new opportunity to study the role of miRNAs in non-model plant species. In this work, we used a combination of Northern blot and tissue print hybridization analysis to identify conserved miRNAs expressed during prickly pear cactus (Opuntia ficus indica) fruit development. Comparative profiling detected the expression of 34 miRNAs, which were clustered in three different groups that were associated with the different phases of fruit development. Variation in the level of miRNA expression was observed. Gradual expression increase of several miRNAs was observed during fruit development, including miR164. miR164 was selected for stem-loop RT-PCR and for a detailed spatial-temporal expression analysis. At early floral stages, miR164 was mainly localized in meristematic tissues, boundaries and fusion zones, while it was more homogenously expressed in fruit tissues. Our results provide the first evidence of miRNA expression in the prickly pear cactus and provide the basis for future research on miRNAs in Opuntia. Moreover, our analyses suggest that miR164 plays different roles during prickly pear cactus fruit development. PMID:25366556

  15. miRviewer: a multispecies microRNA homologous viewer

    Directory of Open Access Journals (Sweden)

    Kiezun Adam

    2012-02-01

    Full Text Available Abstract Background MicroRNAs (miRNAs are short non-coding RNAs that regulate gene expression via binding to the 3' ends of mRNAs. MiRNAs have been associated with many cellular events ascertaining their central role in gene regulation. In order to better understand miRNAs of interest it is of utmost importance to learn about the genomic conservation of these genes. Findings The miRviewer web-server, presented here, encompasses all known miRNAs of currently fully annotated animal genomes in a visual 'birds-eye' view representation. miRviewer provides a graphical outlook of the current miRNA world together with sequence alignments and secondary structures of each miRNA. As a test case we experimentally examined the expression of several miRNAs in various animals. Conclusions miRviewer completes the homologous miRNA space with hundreds of unreported miRNAs and is available at: http://people.csail.mit.edu/akiezun/miRviewer

  16. Inference of Gene Regulation via miRNAs During ES Cell Differentiation Using MiRaGE Method

    OpenAIRE

    Jun Yasuda; Y-h. Taguchi; Masato Yoshizawa

    2011-01-01

    MicroRNA (miRNA) is a critical regulator of cell growth, differentiation, and development. To identify important miRNAs in a biological process, many bioinformatical tools have been developed. We have developed MiRaGE (MiRNA Ranking by Gene Expression) method to infer the regulation of gene expression by miRNAs from changes of gene expression profiles. The method does not require precedent array normalization. We applied the method to elucidate possibly important miRNAs during embryonic stem ...

  17. Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype.

    OpenAIRE

    Isozaki, K; Tsujimura, T; Nomura, S; Morii, E; Koshimizu, U.; Nishimune, Y; Kitamura, Y.

    1994-01-01

    The mi locus of mice encodes a novel member of the basic-helix-loop-helix-leucine zipper protein family of transcription factors (hereafter called mi factor). In addition to microphthalmus, osteopetrosis, and lack of melanocytes, mice of mi/mi genotype are deficient in mast cells. Since the c-kit receptor tyrosine kinase plays an important role in the development of mast cells, and since the c-kit expression by cultured mast cells from mi/mi mice is deficient in both mRNA and protein levels, ...

  18. Evaluation of miR-21 and miR-375 as prognostic biomarkers in esophageal cancer

    DEFF Research Database (Denmark)

    Winther, Mette; Alsner, Jan; Tramm, Trine;

    2015-01-01

    BACKGROUND: MicroRNAs (miRNAs) have been associated with prognosis in esophageal cancer, suggesting a role for miRNAs to help guide treatment decisions. Especially, miR-21 and miR-375 have been investigated as prognostic biomarkers. The aim of this study was to evaluate the prognostic potential of...... miR-21 and miR-375 in primary esophageal squamous cell carcinomas (ESCC) and esophagogastric adenocarcinomas (EAC). MATERIAL AND METHODS: Pre-therapeutic tumor specimens from 195 patients with loco-regional esophageal cancer treated with neoadjuvant or definitive chemoradiotherapy or perioperative...

  19. Stosunki międzynarodowe a kultura

    OpenAIRE

    Kujawińska Courtney, Krystyna

    2016-01-01

    Pomysł na przygotowanie tej monografii pojawił się w związku z chęcią podsumowania bogatego dorobku naukowego samodzielnych pracowników nauki Wydziału Studiów Międzynarodowych i Politologicznych Uniwersytetu Łódzkiego. Publikacja ma na celu ukazanie eksperckiego potencjału tego zespołu, który zajmuje się bardzo szerokim spektrum międzynarodowych problemów politycznych, społecznych, ekonomicznych i kulturowych. Interdyscyplinarność jest traktowana jako ważny atut prowadzonych przez nas bad...

  20. Lake Morphometry for NHD Lakes in Ohio Region 5 HUC

    Data.gov (United States)

    U.S. Environmental Protection Agency — Lake morphometry metrics are known to influence productivity in lakes and are important for building various types of ecological and environmental models of lentic...

  1. Lake Morphometry for NHD Lakes in Tennessee Region 6 HUC

    Data.gov (United States)

    U.S. Environmental Protection Agency — Lake morphometry metrics are known to influence productivity in lakes and are important for building various types of ecological and environmental models of lentic...

  2. Lake Morphometry for NHD Lakes in California Region 18 HUC

    Data.gov (United States)

    U.S. Environmental Protection Agency — Lake morphometry metrics are known to influence productivity in lakes and are important for building various types of ecological and environmental models of lentic...

  3. Winter Lake Breezes near the Great Salt Lake

    Science.gov (United States)

    Crosman, Erik T.; Horel, John D.

    2016-05-01

    Case studies of lake breezes during wintertime cold air pools in Utah's Salt Lake Valley are examined. While summer breezes originating from the Great Salt Lake are typically deeper, of longer duration, and have higher wind speeds than winter breezes, the rate of inland penetration and cross-frontal temperature differences can be higher during the winter. The characteristics of winter breezes and the forcing mechanisms controlling them (e.g., snow cover, background flow, vertical stability profile, clouds, lake temperature, lake sheltering, and drainage pooling) are more complex and variable than those evident in summer. During the afternoon in the Salt Lake Valley, these lake breezes can lead to elevated pollution levels due to the transport of fine particle pollutants from over the Great Salt Lake, decreased vertical mixing depth, and increased vertical stability.

  4. Meteotsunami in Lake Michigan

    Science.gov (United States)

    Wu, C.; Bechle, A.; Schwab, D. J.; Anderson, E. J.; Roebber, P. J.

    2012-12-01

    Meteotsunamis, or meteorological induced tsunamis, are meteorological in origin but exhibit long-period tsunami characteristics. Both meteotsunamis and seismic tsunamis have wave periods of 2 minutes to 2 hours and undergo resonant amplification that transforms relatively small waves in the open water into destructive forces at the coast. There are a number of amplification mechanisms including Proudman resonance, edge wave Greenspan resonance, as well as shoaling and harbor resonance. In this talk, we discuss several incidences of meteotsunamis in the Great Lakes. In Lake Michigan, an unexpected and destructive meteotsunami event occurred on June 26, 1954 when a 3 meter high wave struck the Chicago waterfront, resulting in seven fatalities. Ten days later on July 6, 1954, another meteotsunami event in southern Lake Michigan resulted in edge waves in excess of 1 m height. Nevertheless, these two events were generated by storms of vastly different size and propagation direction. More recently, in 2008 at least 25 meteotsunamis events with amplitudes of to 30 ~ 45 cm were observed in several major Lake Michigan harbors and were correlated with high-frequency pressure fronts passing along the west coast of Lake Michigan. Historical water level and meteorological records are analyzed to determine the mechanisms responsible for these meteotsunami events. Finally, a three-dimensional hydrodynamic model is employed to simulate select events to further explore in detail the possible meteotsunami mechanisms in the Great Lakes. Our ultimate goal is to provide real-time warning system to assess the coastal hazard and risk areas associated with meteotsunamis in the Great Lakes.

  5. Specific miRNA Stabilization by Gld2-Catalyzed Monoadenylation

    Directory of Open Access Journals (Sweden)

    Andrea D’Ambrogio

    2012-12-01

    Full Text Available MicroRNAs (miRNAs are small, noncoding RNAs that inhibit translation and promote mRNA decay. The levels of mature miRNAs are the result of different rates of transcription, processing, and turnover. The noncanonical polymerase Gld2 has been implicated in the stabilization of miR-122, possibly through catalyzing 3′ monoadenylation; however, there is little evidence that this relationship is one of cause and effect. Here, we biochemically characterize Gld2’s involvement in miRNA monoadenylation and its effect on miRNA stability. We find that Gld2 directly monoadenylates and stabilizes specific miRNA populations in human fibroblasts and that sensitivity to monoadenylation-induced stability depends on nucleotides in the miRNA 3′ end. These results establish a mechanism of miRNA stability and resulting posttranscriptional gene regulation.

  6. Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 Increases Neovascularization and Blood Flow Recovery After Ischemia

    DEFF Research Database (Denmark)

    Welten, S. M. J.; Bastiaansen, Ajnm; de Jong, R. C. M.; de Vries, M. R.; Peters, E. A. B.; Boonstra, M. C.; Sheikh, S. P.; La Monica, N.; Kandimalla, E. R.; Quax, P. H. A.; Nossent, A. Y.

    2014-01-01

    in mice after single femoral artery ligation. Methods and Results: Gene silencing oligonucleotides (GSOs) were used to inhibit 4 14q32 microRNAs, miR-329, miR-487b, miR-494, and miR-495, 1 day before double femoral artery ligation. Blood flow recovery was followed by laser Doppler perfusion imaging...... well as to increased arterial myofibroblast proliferation. Conclusions: The 14q32 microRNA gene cluster is highly involved in neovascularization. Inhibition of 14q32 microRNAs miR-329, miR-487b, miR-494, and miR-495 provides a promising tool for future therapeutic neovascularization....

  7. Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation.

    Science.gov (United States)

    Pisano, Federica; Altomare, Claudia; Cervio, Elisabetta; Barile, Lucio; Rocchetti, Marcella; Ciuffreda, Maria Chiara; Malpasso, Giuseppe; Copes, Francesco; Mura, Manuela; Danieli, Patrizia; Viarengo, Gianluca; Zaza, Antonio; Gnecchi, Massimiliano

    2015-04-01

    Several studies have demonstrated that miRNA are involved in cardiac development, stem cell maintenance, and differentiation. In particular, it has been shown that miRNA133, miRNA1, and miRNA499 are involved in progenitor cell differentiation into cardiomyocytes. However, it is unknown whether different miRNA may act synergistically to improve cardiac differentiation. We used mouse P19 cells as a cardiogenic differentiation model. miRNA499, miRNA1, or miRNA133 were transiently over-expressed in P19 cells individually or in different combinations. The over-expression of miRNA499 alone increased the number of beating cells and the association of miRNA499 with miRNA133 exerted a synergistic effect, further increasing the number of beating cells. Real-time polymerase chain reaction showed that the combination of miRNA499 + 133 enhanced the expression of cardiac genes compared with controls. Western blot and immunocytochemistry for connexin43 and cardiac troponin T confirmed these findings. Importantly, caffeine responsiveness, a clear functional parameter of cardiac differentiation, was increased by miRNA499 in association with miRNA133 and was directly correlated with the activation of the cardiac troponin I isoform promoter. Cyclic contractions were reversibly abolished by extracellular calcium depletion, nifedipine, ryanodine, and IP3R blockade. Finally, we demonstrated that the use of miRNA499 + 133 induced cardiac differentiation even in the absence of dimethyl sulfoxide. Our results show that the areas spontaneously contracting possess electrophysiological and pharmacological characteristics compatible with true cardiac excitation-contraction coupling. The translational relevance of our findings was reinforced by the demonstration that the over-expression of miRNA499 and miRNA133 was also able to induce the differentiation of human mesenchymal stromal cells toward the cardiac lineage. PMID:25534971

  8. miR-24 and miR-205 expression is dependent on HPV onco-protein expression in keratinocytes

    Energy Technology Data Exchange (ETDEWEB)

    McKenna, Declan J., E-mail: dj.mckenna@ulster.ac.uk [Biomedical Sciences Research Institute, University of Ulster, Coleraine, Co. Derry BT52 1SA (United Kingdom); Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen' s University Belfast, Belfast BT9 7BL (United Kingdom); Patel, Daksha, E-mail: d.patel@qub.ac.uk [Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen' s University Belfast, Belfast BT9 7BL (United Kingdom); McCance, Dennis J., E-mail: d.mccance@qub.ac.uk [Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen' s University Belfast, Belfast BT9 7BL (United Kingdom)

    2014-01-05

    A screen of microRNA (miRNA) expression following differentiation in human foreskin keratinocytes (HFKs) identified changes in several miRNAs, including miR-24 and miR-205. We investigated how expression of Human Papilloma Virus Type-16 (HPV16) onco-proteins E6 and E7 affected expression of miR-24 and miR-205 during proliferation and differentiation of HFKs. We show that the induction of both miR-24 and miR-205 observed during differentiation of HFKs is lost in HFKs expressing E6 and E7. We demonstrate that the effect on miR-205 is due to E7 activity, as miR-205 expression is dependent on pRb expression. Finally, we provide evidence that miR-24 effects in the cell may be due to targeting of cyclin dependent kinase inhibitor p27. In summary, these results indicate that expression of both miR-24 and miR-205 are impacted by E6 and/or E7 expression, which may be one mechanism by which HPV onco-proteins can disrupt the balance between proliferation and differentiation in keratinocytes. - Highlights: • miR-24 and miR-205 are induced during keratinocyte differentiation. • This induction is lost in keratinocytes expressing HPV onco-proteins E6 and E7. • miR-205 is dependent upon pRb expression. • miR-24 targets p27 in cycling keratinocytes.

  9. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jong-Kook [College of Pharmacy, Ohio State University, Columbus, OH 43210 (United States); Henry, Jon C. [Department of Surgery, Ohio State University, Columbus, OH 43210 (United States); Jiang, Jinmai [College of Pharmacy, Ohio State University, Columbus, OH 43210 (United States); Esau, Christine [Regulus Therapeutics, Carlsbad, CA (United States); Gusev, Yuriy [Lombardi Cancer Center, Georgetown University, Washington, DC (United States); Lerner, Megan R. [Veterans Affairs Medical Center, Oklahoma City, OK (United States); Postier, Russell G. [Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States); Brackett, Daniel J. [Veterans Affairs Medical Center, Oklahoma City, OK (United States); Schmittgen, Thomas D., E-mail: Schmittgen.2@osu.edu [College of Pharmacy, Ohio State University, Columbus, OH 43210 (United States)

    2011-03-25

    Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

  10. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    International Nuclear Information System (INIS)

    Research highlights: → The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. → miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. → miR-132 and miR-212 expression is increased by a β2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G2/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the β2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The β2 adrenergic pathway may play an important role in this novel mechanism.

  11. Decreased expression of miR-21, miR-26a, miR-29a, and miR-142-3p in CD4⁺ T cells and peripheral blood from tuberculosis patients.

    Directory of Open Access Journals (Sweden)

    Katja Kleinsteuber

    Full Text Available The vast majority of Mycobacterium tuberculosis (M. tuberculosis infected individuals are protected from developing tuberculosis and T cells are centrally involved in this process. MicroRNAs (miRNA regulate T-cell functions and are biomarker candidates of disease susceptibility and treatment efficacy in M. tuberculosis infection. We determined the expression profile of 29 selected miRNAs in CD4(+ T cells from tuberculosis patients and contacts with latent M. tuberculosis infection (LTBI. These analyses showed lower expression of miR-21, miR-26a, miR-29a, and miR-142-3p in CD4(+ T cells from tuberculosis patients. Whole blood miRNA candidate analyses verified decreased expression of miR-26a, miR-29a, and miR-142-3p in children with tuberculosis as compared to healthy children with LTBI. Despite marked variances between individual donor samples, trends of increased miRNA candidate expression during treatment and recovery were observed. Functional in vitro analysis identified increased miR-21 and decreased miR-26a expression after re-stimulation of T cells. In vitro polarized Interleukin-17 positive T-cell clones showed activation-dependent miR-29a up-regulation. In order to characterize the role of miR-29a (a described suppressor of Interferon-γ in tuberculosis, we analyzed M. tuberculosis specific Interferon-γ expressing T cells in children with tuberculosis and healthy contacts but detected no correlation between miR-29a and Interferon-γ expression. Suppression of miR-29a in primary human T cells by antagomirs indicated no effect on Interferon-γ expression after in vitro activation. Finally, classification of miRNA targets revealed only a moderate overlap between the candidates. This may reflect differential roles of miR-21, miR-26a, miR-29a, and miR-142-3p in T-cell immunity against M. tuberculosis infection and disease.

  12. MIGRATION AND POLITICAL ASYLUM

    OpenAIRE

    LUPSA FLORENTINA

    2014-01-01

    Migration is an important topic on the public agenda, as well as in the area of effervescent political debate and public policies, and has been so especially in this past decade, in the national and European plane. The recorded evolutions may easily exemplify the way in which liberal democracies function and the process of European construction, implicitly the process of change in the immigration policy, degree of adaptability and opening to change, the controversial character and the difficu...

  13. Lake Michigan lake trout PCB model forecast post audit

    Science.gov (United States)

    Scenario forecasts for total PCBs in Lake Michigan (LM) lake trout were conducted using the linked LM2-Toxics and LM Food Chain models, supported by a suite of additional LM models. Efforts were conducted under the Lake Michigan Mass Balance Study and the post audit represents th...

  14. Mono Lake Excursion Reviewed

    Science.gov (United States)

    Liddicoat, J. C.; Coe, R. S.

    2007-05-01

    The Mono Lake Excursion as recorded in the Mono Basin, CA, has an older part that is about negative 30 degrees inclination and about 300 degrees declination during low relative field intensity. Those paleomagnetic directions are closely followed by greater than 80 degrees positive inclination and east declination of about 100 degrees during higher relative field intensity. A path of the Virtual Geomagnetic Poles (VGPs) for the older part followed from old to young forms a large clockwise loop that reaches 35 degrees N latitude and is centered at about 35 degrees E longitude. That loop is followed by a smaller one that is counterclockwise and centered at about 70 degrees N latitude and 270 degrees E longitude (Denham & Cox, 1971; Denham, 1974; Liddicoat & Coe, 1979). The Mono Lake Excursion outside the Mono Basin in western North America is recorded as nearly the full excursion at Summer Lake, OR (Negrini et al., 1984), and as the younger portion of steep positive inclination/east declination in the Lahontan Basin, NV. The overall relative field intensity during the Mono Lake Excursion in the Lahontan Basin mirrors very closely the relative field intensity in the Mono Basin (Liddicoat, 1992, 1996; Coe & Liddicoat, 1994). Using 14C and 40Ar/39Ar dates (Kent et al., 2002) and paleoclimate and relative paleointensity records (Zimmerman et al., 2006) for the Mono Lake Excursion in the Mono Basin, it has been proposed that the Mono Lake Excursion might be older than originally believed and instead be the Laschamp Excursion at about 40,000 yrs B.P. (Guillou et al., 2004). On the contrary, we favor a younger age for the Mono Lake Excursion, about 32,000 yrs B.P., using the relative paleointensity in the Mono Basin and Lahontan Basin and 14C dates from the Lahontan Basin (Benson et al., 2002). The age of about 32,000 yrs B.P. is also in accord with the age (32,000- 34,000 yrs B.P.) reported by Channell (2006) for the Mono Lake Excursion at ODP Site 919 in the Irminger Basin

  15. Great Lakes Environmental Database (GLENDA)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Great Lakes Environmental Database (GLENDA) houses environmental data on a wide variety of constituents in water, biota, sediment, and air in the Great Lakes...

  16. Protein-driven inference of miRNA-disease associations

    DEFF Research Database (Denmark)

    Mørk, Søren; Pletscher-Frankild, Sune; Palleja, Albert; Gorodkin, Jan; Jensen, Lars Juhl

    2014-01-01

    MicroRNAs (miRNAs) are a highly abundant class of non-coding RNA genes involved in cellular regulation and thus also diseases. Despite miRNAs being important disease factors, miRNA-disease associations remain low in number and of variable reliability. Furthermore, existing databases and prediction...

  17. Protocol for miRNA isolation from biofluids.

    Science.gov (United States)

    Lekchnov, Evgeny A; Zaporozhchenko, Ivan A; Morozkin, Evgeny S; Bryzgunova, Olga E; Vlassov, Valentin V; Laktionov, Pavel P

    2016-04-15

    MicroRNAs (miRNAs) have been identified as promising biomarkers in cancer and other diseases. Packaging of miRNAs into vesicles and complexes with proteins ensures their stability in biological fluids but also complicates their isolation. Conventional protocols used to isolate cell-free RNA are generally successful in overcoming these difficulties; however, they are costly, labor-intensive, or heavily reliant on the use of hazardous chemicals. Here we describe a protocol that is suitable for isolating miRNAs from biofluids, including blood plasma and urine. The protocol is based on precipitation of proteins, denaturation of miRNA-containing complexes with octanoic acid and guanidine isothiocyanate, and subsequent purification of miRNA on spin columns. The efficacy of miRNA extraction by phenol-chloroform extraction, miRCURY RNA isolation kit--biofluids (Exiqon), and the proposed protocol was compared by quantitative reverse-transcription PCR of miR-16 and miR-126. The proposed protocol was slightly more effective for isolating miRNA from plasma and significantly superior to the other two methods for miRNA isolation from urine. Spectrophotometry and SDS-PAGE data suggest that the disparity in performance between miRCURY Biofluids and the proposed protocol can be attributed to differences in precipitation mechanisms, as confirmed by the retention of different proteins in the supernatant. PMID:26874020

  18. El flamenco en mi obra compositiva

    OpenAIRE

    Rafael Díaz

    2014-01-01

    Siendo andaluz y en contacto casi permanente con el flamenco mi obra musical está marcad por la tradición de la música española cercana al flamenco más la influencia de la música electroacústica que juntas configuran una estética que llamó nuevo nacionalismo.

  19. Mini Networked Screens (MiNeS)

    NARCIS (Netherlands)

    Prins, C.A.; Maris, M.; Breen, P.C.; Versteeg, N.; Terwisga, P.F. van; Ort, C.M.; Blok, J.J.

    2005-01-01

    The forward areas for an LPD in littoral waters can be full of surprises. A novel concept is presented for a networked screen consisting of elements of increasing capability to provide a progressive response to the threat. This MiNeS concept substantially improves the capability of the LPD as an aut

  20. miRNAting control of DNA methylation

    Indian Academy of Sciences (India)

    Ashwani Jha; Ravi Shankar

    2014-06-01

    DNA methylation is a type of epigenetic modification where a methyl group is added to the cytosine or adenine residue of a given DNA sequence. It has been observed that DNA methylation is achieved by some collaborative agglomeration of certain proteins and non-coding RNAs. The assembly of IDN2 and its homologous proteins with siRNAs recruits the enzyme DRM2, which adds a methyl group at certain cytosine residues within the DNA sequence. In this study, it was found that de novo DNA methylation might be regulated by miRNAs through systematic targeting of the genes involved in DNA methylation. A comprehensive genome-wide and system-level study of miRNA targeting, transcription factors, DNA-methylation-causing genes and their target genes has provided a clear picture of an interconnected relationship of all these factors which regulate DNA methylation in Arabidopsis. The study has identified a DNA methylation system that is controlled by four different genes: IDN2, IDNl1, IDNl2 and DRM2. These four genes along with various critical transcription factors appear to be controlled by five different miRNAs. Altogether, DNA methylation appears to be a finely tuned process of opposite control systems of DNA-methylation-causing genes and certain miRNAs pitted against each other.

  1. 78 FR 36631 - Michigan Disaster #MI-00039

    Science.gov (United States)

    2013-06-18

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Michigan Disaster MI-00039 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... INFORMATION CONTACT: A. Escobar, Office of Disaster Assistance, U.S. Small Business Administration, 409...

  2. Differential expression of miR-139, miR-486 and miR-21 in breast cancer patients sub-classified according to lymph node status

    DEFF Research Database (Denmark)

    Rask, Lene; Balslev, Eva; Søkilde, Rolf;

    2014-01-01

    -5p were found to be down-regulated in patients with lymph node metastases, whereas miR-21 was found to be up-regulated in patients with a positive lymph node status. miR-21 expression levels were found to significantly correlate with tumour size (r = 0.403, p = 0.009; Spearman's rank), whereas no...... relation was found between miR-21 and PTEN expression levels (Kruskal-Wallis test). CONCLUSION: Down-regulation of miR-486-5p and miR-139-5p, in conjunction with up-regulation of miR-21, may represent a useful signature for the identification of high-risk breast cancer patients....... the most consistently up-regulated miRNAs is miR-21. Here, we specifically searched for differentially expressed miRNAs in high-risk breast cancer patients as compared to low-risk breast cancer patients. In the same patients, we also compared miR-21 expression with the expression of its presumed...

  3. Microplastic pollution in lakes and lake shoreline sediments - A case study on Lake Bolsena and Lake Chiusi (central Italy).

    Science.gov (United States)

    Fischer, Elke Kerstin; Paglialonga, Lisa; Czech, Elisa; Tamminga, Matthias

    2016-06-01

    Rivers and effluents have been identified as major pathways for microplastics of terrestrial sources. Moreover, lakes of different dimensions and even in remote locations contain microplastics in striking abundances. This study investigates concentrations of microplastic particles at two lakes in central Italy (Lake Bolsena, Lake Chiusi). A total number of six Manta Trawls have been carried out, two of them one day after heavy winds occurred on Lake Bolsena showing effects on particle distribution of fragments and fibers of varying size categories. Additionally, 36 sediment samples from lakeshores were analyzed for microplastic content. In the surface waters 2.68 to 3.36 particles/m(3) (Lake Chiusi) and 0.82 to 4.42 particles/m(3) (Lake Bolsena) were detected, respectively. Main differences between the lakes are attributed to lake characteristics such as surface and catchment area, depth and the presence of local wind patterns and tide range at Lake Bolsena. An event of heavy winds and moderate rainfall prior to one sampling led to an increase of concentrations at Lake Bolsena which is most probable related to lateral land-based and sewage effluent inputs. The abundances of microplastic particles in sediments vary from mean values of 112 (Lake Bolsena) to 234 particles/kg dry weight (Lake Chiusi). Lake Chiusi results reveal elevated fiber concentrations compared to those of Lake Bolsena what might be a result of higher organic content and a shift in grain size distribution towards the silt and clay fraction at the shallow and highly eutrophic Lake Chiusi. The distribution of particles along different beach levels revealed no significant differences. PMID:27104923

  4. The Lake Ohrid SCOPSCO project

    OpenAIRE

    Wagner, Bernd; Wilke, Thomas; Krastel , Sebastien; Zanchetta, Giovanni; Sulpizio, Roberto; Leng, Melanie J.; Francke, Alexander; Baumgarten, Henricke; Cvetkoska, Aleksandra; Giacco, Biagio; Lacey, Jack H.; Leicher, Niklas

    2015-01-01

    The ICDP SCOPSCO project at Lake Ohrid in Macedonia and Albania was one of the most successful lake drilling campaigns worldwide. Drilling took place from April to June 2013 and yielded more than 2000 m of sediments from four different sites in the lake. The maximum penetration was 569 m below lake floor and the overall recovery at all drill sites was > 95 %. Almost two years after the drilling operation, core opening and processing as well as biological and geological analyses ar...

  5. Special Stamps:Qinghai Lake

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    On July 20, 2002, the State Postal Bureau issued a set of three stamps picturing the Qinghai Lake shore, Bird Island, and the distant view.Located on the northeastern Qinghai-Tibet Plateau, in West China’s Qinghai Province, Qinghai Lake is 3,196 meters above sea level, and the biggest inland lake in China. Oils have been used to capture its magnificence.Bird Island on Qinghai Lake is a

  6. The Lake Albert light fishery

    OpenAIRE

    2009-01-01

    Fishing using light to attract fish (The light fishery) was introduced on Lake AIbert from Lake Victoria where it is used to catch mukene Rastrineobola argentea. The light fishery on Lake Albert targets ragoge brycinus nurse and mukene/muziri (Neobola bredoi), These species species now contribute to more than 50% of the catches from this lake. Ragoge and muziri were until the early 1990's not important in the commercial fishery but only served as food to the large predatory fis...

  7. HYDRODYNAMIC CHARACTERISTICS OF LAKE YANAKA

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    As part of a major effort to undersand and quantify the cnvironmental conditions in Lake Yanaka, the circulation patterns in Lake Yanaka were analyzed through the application of a three-dimensional hydrodynamic model. The model was validated with field observation, and then used to study the response of the lake to different forcing. The information on flow structures obtained in the present study is useful for further study of water quality in the lake.

  8. Identification of novel miRNAs and miRNA dependent developmental shifts of gene expression in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Shuhua Zhan

    Full Text Available microRNAs (miRNAs are small, endogenous RNAs of 20 approximately 25 nucleotides, processed from stem-loop regions of longer RNA precursors. Plant miRNAs act as negative regulators of target mRNAs predominately by slicing target transcripts, and a number of miRNAs play important roles in development. We analyzed a number of published datasets from Arabidopsis thaliana to characterize novel miRNAs, novel miRNA targets, and miRNA-regulated developmental changes in gene expression. These data include microarray profiling data and small RNA (sRNA deep sequencing data derived from miRNA biogenesis/transport mutants, microarray profiling data of mRNAs in a developmental series, and computational predictions of conserved genomic stem-loop structures. Our conservative analyses identified five novel mature miRNAs and seven miRNA targets, including one novel target gene. Two complementary miRNAs that target distinct mRNAs were encoded by one gene. We found that genes targeted by known miRNAs, and genes up-regulated or down-regulated in miRNA mutant inflorescences, are highly expressed in the wild type inflorescence. In addition, transcripts upregulated within the mutant inflorescences were abundant in wild type leaves and shoot meristems and low in pollen and seed. Downregulated transcripts were abundant in wild type pollen and seed and low in shoot meristems, roots and leaves. Thus, disrupting miRNA function causes the inflorescence transcriptome to resemble the leaf and meristem and to differ from pollen and seed. Applications of our computational approach to other species and the use of more liberal criteria than reported here will further expand the number of identified miRNAs and miRNA targets. Our findings suggest that miRNAs have a global role in promoting vegetative to reproductive transitions in A. thaliana.

  9. A Lake Dream in Asia

    Institute of Scientific and Technical Information of China (English)

    Yang Wei

    2009-01-01

    @@ When William Wordsworth,representative of Lake Poets wrote his Ode to Night ingale nearby the Lake District of England at the turn of the nine-teenth century,he never imagined a century later,a similar romantic lake dream has been created in China,Asia.

  10. Michigan: The Great Lakes State

    Science.gov (United States)

    McKay, Sandra Lee; La Luzerne-Oi, Sally

    2009-01-01

    Although Michigan is often called the "Wolverine State," its more common nickname is the "Great Lakes State." This name comes from the fact that Michigan is the only state in the United States that borders four of the five Great Lakes. Also referred to as the "Water Wonderland," Michigan has 11,000 additional lakes, 36,000 miles of streams, and…

  11. HYDROMETEOROLGICAL ANALISIS OF DOJRAN LAKE

    Directory of Open Access Journals (Sweden)

    VIOLETA GJESOVSKA

    2011-03-01

    Full Text Available Dojran Lake with its hydrological basin is a closed hydrologicalsystem with natural inflow of water to the lake, but no natural outflow. Rechargeof the lake is from direct surface and underground inflow. Within the period 1950-1960 the lake faced with extremely high water level that was not favorable for thedevelopment of fishing. It was built an artificial channel to regulate the water levelin the lake and control the water use at Greek side of the lake. In the period 1988-2000, the water level in the lake continuously was declining. Water leveldeclination caused ecological catastrophe for the flora and fauna in the lake andlake’s basin that was inconvenience for the basic economy in the region, tourismand fishing. The reasons for declining the water level in the lake are not clearlyidentified, and they are located in unfavorable hydrological conditions expressedthrough longer dried period or uncontrolled usage the water from the lake.In 2002, the Republic of Macedonia finished a project to build a system forbringing water from Gjavato wells near Vardar River with capacity of 1 m3/s. Thewater level in the lake has recently increased. In order to define the causes ofchanges in the lake requires detailed hydrological and meteorological analysis.This paper will present the results of hydrological and meteorological analysis onthe basis of historical data of measured water level, precipitation, and airtemperature from hydrometeorological station New Dojran for the period 1961-2008. Some comments on impact factors will be presented as well.

  12. Sediments of Ypacarai Lake

    International Nuclear Information System (INIS)

    Bottom and sestonic sediments of Ypacarai Lake were investigated with XRF and Moessbauer techniques. The 120 km2 lake, depth averages 1.8 m. In addition to the lakes use for recreation, its basin has economic significance. Sediments play an important role in the distribution of trace elements in the aquatic system and as a sink for metals. Bottom and seston samples were taken from 4 different sampling stations which were selected according the morphology and population sites on the shore. The concentration of toxic metals was found to be low and no adverse ecological impact should be expected. The main metallic ion component is iron (1.68%). Moessbauer studies showed this element appears as Fe3+. Iron2+ was not detected. We suggest that Fe3+ acts as the limiting element which controls the eutrophication process. (author) 13 refs.; 2 tabs

  13. Interesting Ziandao Lake

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    LOCATED in Chun’an County, Zhejiang Province, Qiandao Lake (Lake of a Thousand Isles) is a state-level scenic spot and a bright pearl of the golden tourism line between Hangzhou’s West Lake and Anhui’s Huangshan Mountain. Last autumn, we went to Chun’an. It took only three to four hours by coach to travel from Hangzhou to Chun’an. Flanked by mountains on the west, the small county faces water on the east. A street goes across the county; it takes less than half an hour to walk from one end to the other. Small restaurants and shops line the western side of the road,

  14. Unaccompanied minors - the right to express their views : a study of inter-personal and communicative aspects of the asylum interview with unaccompanied minors as experienced by their guardians

    OpenAIRE

    2009-01-01

    Abstract This study explored inter-personal and communicative aspects of the interviews with unaccompanied minor asylum seekers. The aim was to explore how child-specific aspects are being taken care of through the interview form and guardian’s support. Six persons voluntarily engaged as guardians of unaccompanied minors were individually interviewed with the purpose to address the research question. Data material was collected using qualitative, semi-structured interviews. The researc...

  15. If You Want to Go Fast Go Alone, If You Want to Go Far Go Together: On Context-Sensitive Group Treatment of Asylum Seekers and Refugees Traumatized by War and Terror

    OpenAIRE

    Drozdek, B.

    2014-01-01

    This thesis presents a model for understanding psychological consequences of exposure to war, torture and political violence in asylum seekers and refugees. This contextual, developmental, and culture-sensitive model is based on theoretical and empirical findings and implies framing and interpreting of life events in “the ecological environment” and throughout the life-span of a survivor. The model investigates into both sources of damage and resilience in traumatized individuals in order to ...

  16. Lake Morphometry for NHD Lakes in Great Lakes Region 4 HUC

    Data.gov (United States)

    U.S. Environmental Protection Agency — Lake morphometry metrics are known to influence productivity in lakes and are important for building various types of ecological and environmental models of lentic...

  17. A Toolbox for Herpesvirus miRNA Research: Construction of a Complete Set of KSHV miRNA Deletion Mutants

    Directory of Open Access Journals (Sweden)

    Vaibhav Jain

    2016-02-01

    Full Text Available Kaposi’s sarcoma-associated herpesvirus (KSHV encodes 12 viral microRNAs (miRNAs that are expressed during latency. Research into KSHV miRNA function has suffered from a lack of genetic systems to study viral miRNA mutations in the context of the viral genome. We used the Escherichia coli Red recombination system together with a new bacmid background, BAC16, to create mutants for all known KSHV miRNAs. The specific miRNA deletions or mutations and the integrity of the bacmids have been strictly quality controlled using PCR, restriction digestion, and sequencing. In addition, stable viral producer cell lines based on iSLK cells have been created for wildtype KSHV, for 12 individual miRNA knock-out mutants (ΔmiR-K12-1 through -12, and for mutants deleted for 10 of 12 (ΔmiR-cluster or all 12 miRNAs (ΔmiR-all. NGS, in combination with SureSelect technology, was employed to sequence the entire latent genome within all producer cell lines. qPCR assays were used to verify the expression of the remaining viral miRNAs in a subset of mutants. Induction of the lytic cycle leads to efficient production of progeny viruses that have been used to infect endothelial cells. Wt BAC16 and miR mutant iSLK producer cell lines are now available to the research community.

  18. MiR-24 promotes the survival of hematopoietic cells.

    Directory of Open Access Journals (Sweden)

    Tan Nguyen

    Full Text Available The microRNA, miR-24, inhibits B cell development and promotes myeloid development of hematopoietic progenitors. Differential regulation of cell survival in myeloid and lymphoid cells by miR-24 may explain how miR-24's affects hematopoietic progenitors. MiR-24 is reported to regulate apoptosis, either positively or negatively depending on cell context. However, no role for miR-24 in regulating cell death has been previously described in blood cells. To examine miR-24's effect on survival, we expressed miR-24 via retrovirus in hematopoietic cells and induced cell death with cytokine or serum withdrawal. We observed that miR-24 enhanced survival of myeloid and B cell lines as well as primary hematopoietic cells. Additionally, antagonizing miR-24 with shRNA in hematopoietic cells made them more sensitive to apoptotic stimuli, suggesting miR-24 functions normally to promote blood cell survival. Since we did not observe preferential protection of myeloid over B cells, miR-24's pro-survival effect does not explain its promotion of myelopoiesis. Moreover, expression of pro-survival protein, Bcl-xL, did not mimic miR-24's impact on cellular differentiation, further supporting this conclusion. Our results indicate that miR-24 is a critical regulator of hematopoietic cell survival. This observation has implications for leukemogenesis. Several miRNAs that regulate apoptosis have been shown to function as either tumor suppressors or oncogenes during leukemogenesis. MiR-24 is expressed highly in primary acute myelogenous leukemia, suggesting that its pro-survival activity could contribute to the transformation of hematopoietic cells.

  19. Transient Tsunamis in Lakes

    Science.gov (United States)

    Couston, L.; Mei, C.; Alam, M.

    2013-12-01

    A large number of lakes are surrounded by steep and unstable mountains with slopes prone to failure. As a result, landslides are likely to occur and impact water sitting in closed reservoirs. These rare geological phenomena pose serious threats to dam reservoirs and nearshore facilities because they can generate unexpectedly large tsunami waves. In fact, the tallest wave experienced by contemporary humans occurred because of a landslide in the narrow bay of Lituya in 1958, and five years later, a deadly landslide tsunami overtopped Lake Vajont's dam, flooding and damaging villages along the lakefront and in the Piave valley. If unstable slopes and potential slides are detected ahead of time, inundation maps can be drawn to help people know the risks, and mitigate the destructive power of the ensuing waves. These maps give the maximum wave runup height along the lake's vertical and sloping boundaries, and can be obtained by numerical simulations. Keeping track of the moving shorelines along beaches is challenging in classical Eulerian formulations because the horizontal extent of the fluid domain can change over time. As a result, assuming a solid slide and nonbreaking waves, here we develop a nonlinear shallow-water model equation in the Lagrangian framework to address the problem of transient landslide-tsunamis. In this manner, the shorelines' three-dimensional motion is part of the solution. The model equation is hyperbolic and can be solved numerically by finite differences. Here, a 4th order Runge-Kutta method and a compact finite-difference scheme are implemented to integrate in time and spatially discretize the forced shallow-water equation in Lagrangian coordinates. The formulation is applied to different lake and slide geometries to better understand the effects of the lake's finite lengths and slide's forcing mechanism on the generated wavefield. Specifically, for a slide moving down a plane beach, we show that edge-waves trapped by the shoreline and free

  20. Lakes on Mars

    CERN Document Server

    Cabrol, Nathalie A

    2014-01-01

    On Earth, lakes provide favorable environments for the development of life and its preservation as fossils. They are extremely sensitive to climate fluctuations and to conditions within their watersheds. As such, lakes are unique markers of the impact of environmental changes. Past and current missions have now demonstrated that water once flowed at the surface of Mars early in its history. Evidence of ancient ponding has been uncovered at scales ranging from a few kilometers to possibly that of the Arctic ocean. Whether life existed on Mars is still unknown; upcoming missions may find critic

  1. Lake Way uranium project

    Energy Technology Data Exchange (ETDEWEB)

    Eskell, S.; French, R.R.

    1982-01-01

    Several years ago Lake Way was considered by many to be too small and too low in grade to compete with the larger high grade deposits in other parts of Australia, and particularly in the Northern Territory. The pendulum has now swung and as far as Australian uranium resources are concerned Lake Way now has many advantages over the larger, richer deposits in other parts of Australia. These advantages are set out under appropriate headings (size, location, aboriginals, operating procedures, shipping, equity, and timing).

  2. Technologies for lake restoration

    Directory of Open Access Journals (Sweden)

    Helmut KLAPPER

    2003-09-01

    Full Text Available Lakes are suffering from different stress factors and need to be restored using different approaches. The eutrophication remains as the main water quality management problem for inland waters: both lakes and reservoirs. The way to curb the degradation is to stop the nutrient sources and to accelerate the restoration with help of in-lake technologies. Especially lakes with a long retention time need (eco- technological help to decrease the nutrient content in the free water. The microbial and other organic matter from sewage and other autochthonous biomasses, causes oxygen depletion, which has many adverse effects. In less developed countries big reservoirs function as sewage treatment plants. Natural aeration solves problems only partly and many pollutants tend to accumulate in the sediments. The acidification by acid rain and by pyrite oxidation has to be controlled by acid neutralizing technologies. Addition of alkaline chemicals is useful only for soft waters, and technologies for (microbial alkalinization of very acidic hardwater mining lakes are in development. The corrective measures differ from those in use for eutrophication control. The salinization and water shortage mostly occurs if more water is used than available. L. Aral, L. Tschad, the Dead Sea or L. Nasser belong to waters with most severe environmental problems on a global scale. Their hydrologic regime needs to be evaluated. The inflow of salt water at the bottom of some mining lakes adds to stability of stratification, and thus accumulation of hydrogen sulphide in the monimolimnion of the meromictic lakes. Destratification, which is the most used technology, is only restricted applicable because of the dangerous concentrations of the byproducts of biological degradation. The contamination of lakes with hazardous substances from industry and agriculture require different restoration technologies, including subhydric isolation and storage, addition of nutrients for better self

  3. Reclaiming the lake

    DEFF Research Database (Denmark)

    Rasmussen, Mattias Borg

    2016-01-01

    belonging during a weeklong uprising in defense of Lake Conococha. Highlighting the collective actions and personal narratives from participants in the region-wide blockade, the article therefore seeks to understand how dispossessions of environmental resources perceived as common property are cast in terms...... of individual rights that move well beyond the site of conflict. It is therefore argued that the actions to reclaim Lake Conococha were not only a battle for natural resources and clean water, but more fundamentally an attempt to repossess a citizenship that may be constitutionally secured but all...

  4. Lake contamination models…

    OpenAIRE

    Varekamp, Johan C.

    2005-01-01

    "The time to reach steady state in a perfectly mixed reservoir can be derived from the time that it takes for the term exp[-t/R] go to ≈ zero, which occurs if t = 6R, when 99.75% of Cssp has been reached (600 months in the case of the model lake)." J.C. Varekamp. 2003. Lake contamination models for evolution towards steady state. J. Limnol., 62(Suppl.1): 67-72. The above sentence deserves critical consideration on the grounds of physical and experimental arguments. In an elementary physical s...

  5. Reevaluation of lake trout and lake whitefish bioenergetics models

    Science.gov (United States)

    Madenjian, Charles P.; Pothoven, Steve A.; Kao, Yu-Chun

    2013-01-01

    Using a corrected algorithm for balancing the energy budget, we reevaluated the Wisconsin bioenergetics model for lake trout (Salvelinus namaycush) in the laboratory and for lake whitefish (Coregonus clupeaformis) in the laboratory and in the field. For lake trout, results showed that the bioenergetics model slightly overestimated food consumption by the lake trout when they were fed low and intermediate rations, whereas the model predicted food consumption by lake trout fed ad libitum without any detectable bias. The slight bias in model predictions for lake trout on restricted rations may have been an artifact of the feeding schedule for these fish, and we would therefore recommend application of the Wisconsin lake trout bioenergetics model to lake trout populations in the field without any revisions to the model. Use of the Wisconsin bioenergetics model for coregonids resulted in overestimation of food consumption by lake whitefish both in the laboratory and in the field by between 20 and 30%, on average. This overestimation of food consumption was most likely due to overestimation of respiration rate. We therefore adjusted the respiration component of the bioenergetics model to obtain a good fit to the observed consumption in our laboratory tanks. The adjusted model predicted the consumption in the laboratory and the field without any detectable bias. Until a detailed lake whitefish respiration study can be conducted, we recommend application of our adjusted version of the Wisconsin generalized coregonid bioenergetics model to lake whitefish populations in the field.

  6. Epigenetic architecture and miRNA: reciprocal regulators

    DEFF Research Database (Denmark)

    Wiklund, Erik Digman; Kjems, Jørgen; Clark, Susan

    2010-01-01

    Deregulation of epigenetic and microRNA (miRNA) pathways are emerging as key events in carcinogenesis. miRNA genes can be epigenetically regulated and miRNAs can themselves repress key enzymes that drive epigenetic remodeling. Epigenetic and miRNA functions are thus tightly interconnected......RNAs) are considered especially promising in clinical applications, and their biogenesis and function is a subject of active research. In this review, the current status of epigenetic miRNA regulation is summarized and future therapeutic prospects in the field are discussed with a focus on cancer....

  7. Identification of miRNAs contributing to neuroblastoma chemoresistance

    Directory of Open Access Journals (Sweden)

    Duncan Ayers

    2015-01-01

    Conclusions: Based on the initial miRNA findings, this study elucidates the dys-regulation of four miRNAs in three separate NB chemoresistant cell line models, spanning two cell lines (SH-SY5Y and UKF-NB-3 and two chemotherapeutic agents (doxorubicin and etoposide. These miRNAs may thus be possibly linked to chemoresistance induction in NB. Such miRNAs are good candidates to be novel drug targets for future miRNA based therapies against aggressive tumours that are not responding to conventional chemotherapy.

  8. Isolation and Identification of miRNAs in Jatropha curcas

    OpenAIRE

    Chun Ming Wang, Peng Liu, Fei Sun, Lei Li, Peng Liu, Jian Ye, Gen Hua Yue

    2012-01-01

    MicroRNAs (miRNAs) are small noncoding RNAs that play crucial regulatory roles by targeting mRNAs for silencing. To identify miRNAs in Jatropha curcas L, a bioenergy crop, cDNA clones from two small RNA libraries of leaves and seeds were sequenced and analyzed using bioinformatic tools. Fifty-two putative miRNAs were found from the two libraries, among them six were identical to known miRNAs and 46 were novel. Differential expression patterns of 15 miRNAs in root, stem, leave, fruit and seed ...

  9. miRviewer: a multispecies microRNA homologous viewer

    OpenAIRE

    Kiezun Adam; Artzi Shay; Modai Shira; Volk Naama; Isakov Ofer; Shomron Noam

    2012-01-01

    Abstract Background MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via binding to the 3' ends of mRNAs. MiRNAs have been associated with many cellular events ascertaining their central role in gene regulation. In order to better understand miRNAs of interest it is of utmost importance to learn about the genomic conservation of these genes. Findings The miRviewer web-server, presented here, encompasses all known miRNAs of currently fully annotated animal genomes in ...

  10. HIV-miR-H1 evolvability during HIV pathogenesis

    OpenAIRE

    Lamers, Susanna L.; Fogel, Gary B.; Michael S McGrath

    2010-01-01

    The discovery of microRNAs (miRNAs) in viruses has generated considerable attention into their functional relevance in processes such as cell death, viral proliferation, and oncogenesis. Two early studies found no detectable miRNAs expressed within HIV; however, several studies have verified the existence and function of three HIV miRNAs, most notably HIV-miR-TAR, thus making the earlier results controversial. Although miRNAs are highly conserved within most species, HIV is known to have a hi...

  11. 77 FR 41686 - Safety Zone; Sheffield Lake Fireworks, Lake Erie, Sheffield Lake, OH

    Science.gov (United States)

    2012-07-16

    ... DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed Rulemaking A... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Sheffield Lake Fireworks, Lake Erie, Sheffield Lake, OH AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard...

  12. Hydrology of modern and late Holocene lakes, Death Valley, California

    International Nuclear Information System (INIS)

    Above-normal precipitation and surface-water runoff, which have been generally related to the cyclic recurrence of the El Nino-Southern Oscillation, have produced modern ephemeral lakes in the closed-basin Death Valley watershed. This study evaluates the regional hydroclimatic relations between precipitation, runoff, and lake transgressions in the Death Valley watershed. Recorded precipitation, runoff, and spring discharge data for the region are used in conjunction with a closed-basin, lake-water-budget equation to assess the relative contributions of water from these sources to modern lakes in Death Valley and to identify the requisite hydroclimatic changes for a late Holocene perennial lake in the valley. As part of the Yucca Mountain Site Characterization Program, an evaluation of the Quaternary regional paleoflood hydrology of the potential nuclear-waste repository site at Yucca Mountain, Nevada, was planned. The objectives of the evaluation were (1) to identify the locations and investigate the hydraulic characteristics of paleofloods and compare these with the locations and characteristics of modern floods, and (2) to evaluate the character and severity of past floods and debris flows to ascertain the potential future hazards to the potential repository during the pre-closure period (US Department of Energy, 1988). This study addresses the first of these objectives, and the second in part, by assessing and comparing the sizes, locations, and recurrence rates of modern, recorded (1962--83) floods and late Holocene paleofloods for the 8,533-mi2, closed-basin, Death Valley watershed with its contributing drainage basins in the Yucca Mountain site area

  13. Hydrology of modern and late Holocene lakes, Death Valley, California

    Energy Technology Data Exchange (ETDEWEB)

    Grasso, D.N.

    1996-07-01

    Above-normal precipitation and surface-water runoff, which have been generally related to the cyclic recurrence of the El Nino-Southern Oscillation, have produced modern ephemeral lakes in the closed-basin Death Valley watershed. This study evaluates the regional hydroclimatic relations between precipitation, runoff, and lake transgressions in the Death Valley watershed. Recorded precipitation, runoff, and spring discharge data for the region are used in conjunction with a closed-basin, lake-water-budget equation to assess the relative contributions of water from these sources to modern lakes in Death Valley and to identify the requisite hydroclimatic changes for a late Holocene perennial lake in the valley. As part of the Yucca Mountain Site Characterization Program, an evaluation of the Quaternary regional paleoflood hydrology of the potential nuclear-waste repository site at Yucca Mountain, Nevada, was planned. The objectives of the evaluation were (1) to identify the locations and investigate the hydraulic characteristics of paleofloods and compare these with the locations and characteristics of modern floods, and (2) to evaluate the character and severity of past floods and debris flows to ascertain the potential future hazards to the potential repository during the pre-closure period (US Department of Energy, 1988). This study addresses the first of these objectives, and the second in part, by assessing and comparing the sizes, locations, and recurrence rates of modern, recorded (1962--83) floods and late Holocene paleofloods for the 8,533-mi{sup 2}, closed-basin, Death Valley watershed with its contributing drainage basins in the Yucca Mountain site area.

  14. Fish of Bear Lake, Utah

    OpenAIRE

    Palacios, Patsy; Luecke, Chris; Robinson, Justin

    2007-01-01

    There are 13 species of fish found in the waters of Bear Lake. Of those 13, 4 are endemic (found only in Bear Lake). The 4 endemics species are Bonneville cisco, Bonneville whitefish, Bear Lake whitefish, and Bear Lake sculpin. Five of the remaining 9 fish species are native to the region, and 4 are exotic introductions. These native fishes are the Bonneville cutthroat trout, Utah sucker, redside shiner, speckled dace and Utah chub. The exotic fishes are lake trout, common carp, yellow p...

  15. miR-21, miR-221 and miR-222 expression and prostate cancer recurrence among obese and non-obese cases

    Institute of Scientific and Technical Information of China (English)

    Ernest K Amankwah; Evelyn Anegbe; Hyun Park; Julio Pow-Sang; Ardeshir Hakam; Jong Y Park

    2013-01-01

    Recent evidence shows that certain microRNAs (miRNAs) play a role in both obesity and prostate cancer recurrence,but the association between the expression of these miRNAs and obesity in prostate cancer recurrence is unknown.In this study,we examined the effect of the interaction between obesity and miR-21,miR-221 or miR-222 expression on prostate cancer recurrence among 28 recurrent and 37 non-recurrent prostate cancer cases,miRNA expression was determined using quantitative real-time polymerase chain reaction.Cox proportional hazard models adjusting for age at diagnosis,clinical stage and Gleason score were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for recurrence free survival.A significantly (P=0.014) higher proportion of recurrent cases (78.6%) than non-recurrent cases (48.6%) had a low expression of miR-21 and the difference was more prominent in obese than non-obese patients.Multivariate analysis showed that the expression of miR-21 was an independent risk factor for recurrence in obese (HR=6.15,95% CI=1.04-36.48,P=0.045),but not in non-obese (HR=1.28,95% CI=0.30-5.49,P=0.74) cases.A significant association with recurrence was not observed for the expression of miR-221 and miR-222.In summary,our findings show that miR-21 is associated with prostate cancer recurrence after radical prostatectomy and suggest that the differential expression of miR-21 is more prominent in obese than in non-obese cases.Future larger studies are warranted to confirm these initial findings and to elucidate the mechanisms involved.

  16. Exosomal miRNAs as cancer biomarkers and therapeutic targets.

    Science.gov (United States)

    Thind, Arron; Wilson, Clive

    2016-01-01

    Intercommunication between cancer cells and with their surrounding and distant environments is key to the survival, progression and metastasis of the tumour. Exosomes play a role in this communication process. MicroRNA (miRNA) expression is frequently dysregulated in tumour cells and can be reflected by distinct exosomal miRNA (ex-miRNA) profiles isolated from the bodily fluids of cancer patients. Here, the potential of ex-miRNA as a cancer biomarker and therapeutic target is critically analysed. Exosomes are a stable source of miRNA in bodily fluids but, despite a number of methods for exosome extraction and miRNA quantification, their suitability for diagnostics in a clinical setting is questionable. Furthermore, exosomally transferred miRNAs can alter the behaviour of recipient tumour and stromal cells to promote oncogenesis, highlighting a role in cell communication in cancer. However, our incomplete understanding of exosome biogenesis and miRNA loading mechanisms means that strategies to target exosomes or their transferred miRNAs are limited and not specific to tumour cells. Therefore, if ex-miRNA is to be employed in novel non-invasive diagnostic approaches and as a therapeutic target in cancer, two further advances are necessary: in methods to isolate and detect ex-miRNA, and a better understanding of their biogenesis and functions in tumour-cell communication. PMID:27440105

  17. Entropy-based model for miRNA isoform analysis.

    Directory of Open Access Journals (Sweden)

    Shengqin Wang

    Full Text Available MiRNAs have been widely studied due to their important post-transcriptional regulatory roles in gene expression. Many reports have demonstrated the evidence of miRNA isoform products (isomiRs in high-throughput small RNA sequencing data. However, the biological function involved in these molecules is still not well investigated. Here, we developed a Shannon entropy-based model to estimate isomiR expression profiles of high-throughput small RNA sequencing data extracted from miRBase webserver. By using the Kolmogorov-Smirnov statistical test (KS test, we demonstrated that the 5p and 3p miRNAs present more variants than the single arm miRNAs. We also found that the isomiR variant, except the 3' isomiR variant, is strongly correlated with Minimum Free Energy (MFE of pre-miRNA, suggesting the intrinsic feature of pre-miRNA should be one of the important factors for the miRNA regulation. The functional enrichment analysis showed that the miRNAs with high variation, particularly the 5' end variation, are enriched in a set of critical functions, supporting these molecules should not be randomly produced. Our results provide a probabilistic framework for miRNA isoforms analysis, and give functional insights into pre-miRNA processing.

  18. Exploration of miRNA families for hypotheses generation.

    KAUST Repository

    Kamanu, T.K.

    2013-10-15

    Technological improvements have resulted in increased discovery of new microRNAs (miRNAs) and refinement and enrichment of existing miRNA families. miRNA families are important because they suggest a common sequence or structure configuration in sets of genes that hint to a shared function. Exploratory tools to enhance investigation of characteristics of miRNA families and the functions of family-specific miRNA genes are lacking. We have developed, miRNAVISA, a user-friendly web-based tool that allows customized interrogation and comparisons of miRNA families for hypotheses generation, and comparison of per-species chromosomal distribution of miRNA genes in different families. This study illustrates hypothesis generation using miRNAVISA in seven species. Our results unveil a subclass of miRNAs that may be regulated by genomic imprinting, and also suggest that some miRNA families may be species-specific, as well as chromosome- and/or strand-specific.

  19. MiRNA expression profile and miRNA-mRNA integrated analysis (MMIA) during podocyte differentiation.

    Science.gov (United States)

    Li, Zhigui; Wang, Lifeng; Xu, Jing; Yang, Zhuo

    2015-06-01

    The podocyte is a prominent cell type, which encases the capillaries of glomerulus. Podocyte-selective deletion of Dicer or Drosha was reported to induce proteinuria and glomerulosclerosis, suggesting the essential role of microRNA (miRNA) in podocytes for renal function. However, no comprehensive miRNA expression or miRNA-mRNA integrated analysis (MMIA) can be found during podocyte differentiation. Herein, miRNA and mRNA microarrays are presented, which were carried out in differentiated and undifferentiated mouse podocyte cell lines (MPC5). A total of 50 abnormal miRNAs (26 down-regulated and 24 up-regulated) were identified in differentiated and undifferentiated podocytes. Using MMIA, 80 of the 743 mRNAs (>twofold change) were predicted for potential crosstalk with 30 miRNAs of the 50 abnormal miRNAs. In addition, the gene ontology of mRNAs and the pathway analysis of miRNAs revealed a new potential-regulated network during podocyte differentiation. The expressions of three remarkably changed miRNAs (miR-34c, miR-200a and miR-467e) and four mRNAs (Runx1t1, Atp2a2, Glrp1, and Mmp15), were randomly chosen for further validation by the quantitative real-time polymerase chain reaction, and their expression trends were consistent with the microarray data. Reference searching was also conducted to confirm our data and to find potential new molecules and miRNA-target pairs involved in the podocyte differentiation. The dual luciferase reporter assay for miR-200a/GLRX and let-7b/ARL4D confirmed the prediction of MMIA. The results of this study provide a detailed integration of mRNA and miRNA during podocyte differentiation. The molecular integration mode will open up new perspectives for a better understanding of the mechanism during podocyte differentiation. PMID:25433550

  20. Plutonium in the Great Lakes

    International Nuclear Information System (INIS)

    Since 1971 plutonium concentrations have been measured annually in Lake Michigan and Lake Ontario and at less frequent intervals in the other Great Lakes. The concentrations of plutonium in the water column have decreased only slightly during the 7 y of measurement. The residence times for plutonium in the lakes have been estimated by simple time-concentration models. The apparent sinking rates for plutonium have been found to be essentially constant in all the Great Lakes, which suggest that the basic processes that control the concentrations of dissolved plutonium are similar despite considerable differences in chemical, biological, and physical characteristics of the lakes. Analyses of plutonium in water, suspended solids, material from sediment traps, and sediment cores show that considerable resuspension of previously sedimented material into the hypolimnion occurs throughout a major part of the year. A mechanism is proposed to account for the seasonal cycling of plutonium in the epilimnion of Lake Michigan

  1. Temperature Trends in Montane Lakes

    Science.gov (United States)

    Melack, J. M.; Sadro, S.; Jellison, R.

    2014-12-01

    Long-term temperature trends in lakes integrate hydrological and meteorological factors. We examine temperature trends in a small montane lake with prolonged ice-cover and large seasonal snowfall and in a large saline lake. Emerald Lake, located in the Sierra Nevada (California), is representative of high-elevation lakes throughout the region. No significant trend in outflow temperature was apparent from 1991to 2012. Snowfall in the watershed accounted for 93% of the variability in average summer lake temperatures. Mono Lake (California) lies in a closed, montane basin and is hypersaline and monomictic or meromictic. Temperature profiles have been collected from 1982 to 2010. In the upper water column, the July-August-September water temperatures increased 0.8-1.0°C over the 29 years. This rate of warming is less than published estimates based on satellite-derived skin temperatures and will discussed in the context of general limnological interpretation of temperature trends.

  2. Echoes of Bark Lake.

    Science.gov (United States)

    Duenkel, Nicky; Hemstreet, Jeff

    1997-01-01

    Two former staff members reflect on their feelings about the August 1995 closing of Bark Lake Leadership Centre (Ontario, Canada), which for 49 years had offered outdoor adventure and environmental education courses to youth and adults. They discuss their experiences as both students and teachers at the center, which helped shape their careers in…

  3. Lake Ontario: Nearshore Variability

    Science.gov (United States)

    We conducted a high-resolution survey with towed electronic instrumentation along the Lake Ontario nearshore (720 km) at a 20 meter contour. The survey was conducted September 6-10, 2008 with a shorter 300 km survey conducted August 14-15 for comparing of temporal variability. ...

  4. Kunming-Green Lake

    OpenAIRE

    Ai, Chi-Han

    2012-01-01

    Green Lake of Kunming is near Yunnan University. It is a comfortable place for leisure. As Kunming is known as the "city of eternal spring", its perpetual spring-like weather and its annual average temperature of 15 ° C, it is nice to take a walk in the park.

  5. Cold Lake profitability improvement

    International Nuclear Information System (INIS)

    For the past ten years, Imperial Oil Ltd. has been carrying out a world scale commercial project, using cyclic steam stimulation (CSS) to extract bitumen from the Cold Lake area. Because of the very heavy and viscous nature of Cold Lake bitumen, Imperial Oil has employed CSS as a means of in-situ enhanced recovery. Although this method has been very effective, production has been challenged by the cost of generating and treating steam. To comply with pipeline constraints, Cold Lake bitumen has had to be blended with a diluent. The blended product has been a desirable refinery feedstock, however, it sells for less that light sweet crude, clearly indicating the need for unit cost reduction. Since the start-up of operations nearly a decade ago cost reductions have been achieved in many areas, including production technology, water management, fuel efficiency, services and maintenance, people productivity, electricity costs, and chemical costs. The combined value of these reductions was claimed to be about one third of production costs, resulting in significantly improved competitive position and profitable development of the Cold Lake deposit. 5 figs

  6. Prognostic significance of miR-205 in endometrial cancer.

    Directory of Open Access Journals (Sweden)

    Mihriban Karaayvaz

    Full Text Available PURPOSE: microRNAs have emerged as key regulators of gene expression, and their altered expression has been associated with tumorigenesis and tumor progression. Thus, microRNAs have potential as both cancer biomarkers and/or potential novel therapeutic targets. Although accumulating evidence suggests the role of aberrant microRNA expression in endometrial carcinogenesis, there are still limited data available about the prognostic significance of microRNAs in endometrial cancer. The goal of this study is to investigate the prognostic value of selected key microRNAs in endometrial cancer by the analysis of archival formalin-fixed paraffin-embedded tissues. EXPERIMENTAL DESIGN: Total RNAs were extracted from 48 paired normal and endometrial tumor specimens using Trizol based approach. The expression of miR-26a, let-7g, miR-21, miR-181b, miR-200c, miR-192, miR-215, miR-200c, and miR-205 were quantified by real time qRT-PCR expression analysis. Targets of the differentially expressed miRNAs were quantified using immunohistochemistry. Statistical analysis was performed by GraphPad Prism 5.0. RESULTS: The expression levels of miR-200c (P<0.0001 and miR-205 (P<0.0001 were significantly increased in endometrial tumors compared to normal tissues. Kaplan-Meier survival analysis revealed that high levels of miR-205 expression were associated with poor patient overall survival (hazard ratio, 0.377; Logrank test, P = 0.028. Furthermore, decreased expression of a miR-205 target PTEN was detected in endometrial cancer tissues compared to normal tissues. CONCLUSION: miR-205 holds a unique potential as a prognostic biomarker in endometrial cancer.

  7. Lake level variability in Silver Lake, Michigan: a response to fluctuations in lake levels of Lake Michigan

    Science.gov (United States)

    Fisher, Timothy G.; Loope, Walter L.

    2004-01-01

    Sediment from Silver Lake, Michigan, can be used to constrain the timing and elevation of Lake Michigan during the Nipissing transgression. Silver Lake is separated from Lake Michigan by a barrier/dune complex and the Nipissing, Calumet, and Glenwood shorelines of Lake Michigan are expressed landward of this barrier. Two Vibracores were taken from the lake in February 2000 and contain pebbly sand, sand, buried soils, marl, peat, and sandy muck. It is suggested here that fluctuations in the level of Lake Michigan are reflected in Silver Lake since the Chippewa low phase, and possibly at the end of the Algonquin phase. An age of 12,490 B.P. (10,460±50 14C yrs B.P.) on wood from a buried Entisol may record the falling Algonquin phase as the North Bay outlet opened. A local perched water table is indicated by marl deposited before 7,800 B.P. and peat between 7,760-7,000 B.P. when Lake Michigan was at the low elevation Chippewa phase. Continued deepening of the lake is recorded by the transition from peat to sandy muck at 7,000 B.P. in the deeper core, and with the drowning of an Inceptisol nearly 3 m higher at 6,410 B.P. in the shallower core. A rising groundwater table responding to a rising Lake Michigan base level during the Nipissing transgression, rather than a response to mid-Holocene climate change, explains deepening of Silver Lake. Sandy muck was deposited continually in Silver Lake between Nipissing and modern time. Sand lenses within the muck are presumed to be eolian in origin, derived from sand dunes advancing into the lake on the western side of the basin.

  8. Identification and analysis of miRNAs and their targets in ginger using bioinformatics approach.

    Science.gov (United States)

    Singh, Noopur; Srivastava, Swati; Sharma, Ashok

    2016-01-10

    MicroRNAs (miRNAs) are a large family of endogenous small RNAs derived from the non-protein coding genes. miRNA regulates the gene expression at the post-transcriptional level and plays an important role in plant development. Zingiber officinale is an important medicinal plant having numerous therapeutic properties. Its bioactive compound gingerol and essential oil posses important pharmacological and physiological activities. In this study, we used a homology search based computational approach for identifying miRNAs in Z. officinale. A total of 16 potential miRNA families (miR167, miR407, miR414, miR5015, miR5021, miR5644, miR5645, miR5656, miR5658, miR5664, miR827, miR838, miR847, miR854, miR862 and miR864) were predicted in ginger. Phylogenetic and conserved analyses were performed for predicted miRNAs. Thirteen miRNA families were found to regulate 300 target transcripts and play an important role in cell signaling, reproduction, metabolic process and stress. To understand the miRNA mediated gene regulatory control and to validate miRNA target predictions, a biological network was also constructed. Gene ontology and pathway analyses were also done. miR5015 was observed to regulate the biosynthesis of gingerol by inhibiting phenyl ammonia lyase (PAL), a precursor enzyme in the biosynthesis of gingerol. Our results revealed that most of the predicted miRNAs were involved in the regulation of rhizome development. miR5021, miR854 and miR838 were identified to regulate the rhizome development and the essential oil biosynthesis in ginger. PMID:26392033

  9. Modelling of radiocaesium in lakes - lake sensitivity and remedial strategies

    International Nuclear Information System (INIS)

    A given fallout of radiocesium (e.g. after the Chernobyl accident) will be distributed and taken up by biota very differently in various types of lake. Thus, lakes have different ''sensitivities'' to radiocesium. Important environmental factors regulating the biouptake of 137Cs are the lake water retention time and the K concentration of the water. Several practically useful and ecologically relevant methods exist to remediate lakes contaminated by radiocesium, e.g. liming, potash treatment and fertilization of low-productive lakes. The basic aim of this paper is to use a validated, state-of-the-art model for radiocesium in lakes, the VAMP model, first to illustrate the fact that different lakes have different 'sensitivities' and then to simulate the effects of alternative remedial methods. Target variables in these tests are Cs concentrations in lake water and in predatory fish. These results emanate from IAEAs VAMP project. The lakes included in this work cover a wide range of lake and catchment characteristics. (Author)

  10. miRNA 206 and miRNA 574-5p are highly expression in coronary artery disease

    Science.gov (United States)

    Zhou, Jianqing; Shao, Guofeng; Chen, Xiaoliang; Yang, Xi; Huang, Xiaoyan; Peng, Ping; Ba, Yanna; Zhang, Lin; Jehangir, Tashina; Bu, Shizhong; Liu, Ningsheng; Lian, Jiangfang

    2015-01-01

    Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide. Innovative diagnostic biomarkers are a pressing need for this disease. miRNAs profiling is an innovative method of identifying biomarkers for many diseases and could be proven as a powerful tool in the diagnosis and treatment of CAD. We performed miRNA microarray analysis from the plasma of three CAD patients and three healthy controls. Subsequently, we performed quantitative real-time PCR (qRT-PCR) analysis of miRNA expression in plasma of another 67 CAD patients and 67 healthy controls. We identified two miRNAs (miR-206 and miR-574-5p) that were significantly up-regulated in CAD patients as compared with healthy controls (P<0.05). The receiver operating characteristic (ROC) curves indicated these two miRNAs had great potential to provide sensitive and specific diagnostic value for CAD. PMID:26685009

  11. miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity

    DEFF Research Database (Denmark)

    Moore, Michael J; Scheel, Troels K H; Luna, Joseph M;

    2015-01-01

    microRNAs (miRNAs) act as sequence-specific guides for Argonaute (AGO) proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite their importance in many biological processes, rules governing AGO-miRNA targeting are only partially understood. Here we report a modified...... AGO HITS-CLIP strategy termed CLEAR (covalent ligation of endogenous Argonaute-bound RNAs)-CLIP, which enriches miRNAs ligated to their endogenous mRNA targets. CLEAR-CLIP mapped ∼130,000 endogenous miRNA-target interactions in mouse brain and ∼40,000 in human hepatoma cells. Motif and structural...... analysis define expanded pairing rules for over 200 mammalian miRNAs. Most interactions combine seed-based pairing with distinct, miRNA-specific patterns of auxiliary pairing. At some regulatory sites, this specificity confers distinct silencing functions to miRNA family members with shared seed sequences...

  12. The miRNA world of polyomaviruses

    OpenAIRE

    Lagatie, Ole; Tritsmans, Luc; Stuyver, Lieven J

    2013-01-01

    Polyomaviruses are a family of non-enveloped DNA viruses infecting several species, including humans, primates, birds, rodents, bats, horse, cattle, raccoon and sea lion. They typically cause asymptomatic infection and establish latency but can be reactivated under certain conditions causing severe diseases. MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in several cellular processes by binding to and inhibiting the translation of specific mRNA transcripts. In this rev...

  13. The fisheries resources of Lake Nakivali

    OpenAIRE

    2010-01-01

    Lake Nakivali is one of the four small lakes that form what is known as the koki lake sysyem. It is 14km long,6km wide.26km sqaured in area and has maximum depth of 3.5m at high water level. The lake is located in lake-swamp complex with river Rwizi as the principle inflow, and a number of peripheral lakes among which are four major ones,i.e Lake Nakivali, Mburo, Kachira and Kijanebalola. Lake Nakivali is a controlled lake with four official landing sites, namely: Kikusi, Kahirimbi, Kashojwa ...

  14. miR-375 and miR-30d in the effect of chromium-containing Chinese medicine moderating glucose metabolism.

    Science.gov (United States)

    Zhang, Qian; Xiao, Xinhua; Li, Ming; Li, Wenhui; Yu, Miao; Zhang, Huabing; Ping, Fan; Wang, Zhixin; Zheng, Jia; Xiang, HongDing

    2014-01-01

    In China, TianMai Xiaoke tablet (TM) is used to treat type 2 diabetes. However, the exact mechanism of TM is not clear. This study is to investigate the effect of TM on glucose metabolism in diabetic rats and to identify whether TM takes a direct action through microRNAs on islet. Rats were divided into control group, diabetic group, low dose of TM group (TML), and high dose of TM group (TMH). Pancreas samples were analyzed using microRNA array and Q-PCR. Eight-week treatment with TM significantly decreased fasting blood glucose. The blood glucose was significantly reduced in TM-treated groups before and after oral glucose administration. Fasting insulin and HOMA-IR were suppressed in TM-treated groups. miR-448, let-7b, miR-540, miR-296, miR-880, miR-200a, miR-500, miR-10b, miR-336, miR-30d, miR-208, let-7e, miR-142-5p, miR-874, miR-375, miR-879, miR-501, and miR-188 were upregulated, while miR-301b, miR-134, and miR-652 were downregulated in TMH group. Through target gene analysis and real-time PCR verification, we found that these miRNAs, especially miR-375 and miR-30d, can stimulate insulin secretion in islet. Our data suggest that TM can improve blood glucose in diabetic rats which involved increasing the expression of miR-375 and miR-30d to activate insulin synthesis in islet. PMID:24812635

  15. Potential strategies for recovery of lake whitefish and lake herring stocks in eastern Lake Erie

    Science.gov (United States)

    Oldenburg, K.; Stapanian, M.A.; Ryan, P.A.; Holm, E.

    2007-01-01

    Lake Erie sustained large populations of ciscoes (Salmonidae: Coregoninae) 120 years ago. By the end of the 19th century, abundance of lake whitefish (Coregonus clupeaformis) had declined drastically. By 1925, the lake herring (a cisco) population (Coregonus artedii) had collapsed, although a limited lake herring fishery persisted in the eastern basin until the 1950s. In the latter part of the 20th century, the composition of the fish community changed as oligotrophication proceeded. Since 1984, a limited recovery of lake whitefish has occurred, however no recovery was evident for lake herring. Current ecological conditions in Lake Erie probably will not inhibit recovery of the coregonine species. Recovery of walleye (Sander vitreus) and efforts to rehabilitate the native lake trout (Salvelinus namaycush) in Lake Erie will probably assist recovery because these piscivores reduce populations of alewife (Alosa psuedoharengus) and rainbow smelt (Osmerus mordax), which inhibit reproductive success of coregonines. Although there are considerable spawning substrates available to coregonine species in eastern Lake Erie, eggs and fry would probably be displaced by storm surge from most shoals. Site selection for stocking or seeding of eggs should consider the reproductive life cycle of the stocked fish and suitable protection from storm events. Two potential sites in the eastern basin have been identified. Recommended management procedures, including commercial fisheries, are suggested to assist in recovery. Stocking in the eastern basin of Lake Erie is recommended for both species, as conditions are adequate and the native spawning population in the eastern basin is low. For lake herring, consideration should be given to match ecophenotypes as much as possible. Egg seeding is recommended. Egg seeding of lake whitefish should be considered initially, with fingerling or yearling stocking suggested if unsuccessful. Spawning stocks of whitefish in the western basin of Lake

  16. Lake Mead--clear and vital

    Science.gov (United States)

    Wessells, Stephen M.; Rosen, Michael

    2013-01-01

    Lake Mead – Clear and Vital” is a 13 minute documentary relating the crucial role of science in maintaining high water quality in Lake Mead. The program was produced coincident with release of the Lakes Mead and Mohave Circular a USGS publication covering past and on-going research in the lakes and tributaries of the Lake Mead National Recreation Area.

  17. Predicting Maximum Lake Depth from Surrounding Topography

    Science.gov (United States)

    Lake volume aids understanding of the physical and ecological dynamics of lakes, yet is often not readily available. The data needed to calculate lake volume (i.e. bathymetry) are usually only collected on a lake by lake basis and are difficult to obtain across broad regions. ...

  18. Citizen volunteer water monitoring on Smith Lake

    OpenAIRE

    Alabama Water Watch

    2005-01-01

    Publication includes: Lake Facts and Figures; Long-term Trends in Lake Water Quality; Impacts on the Lake and What's Being Done About It; Trouble Waters; Watershed-level Water Quality Differences; Timeline of AAW (Alabama Water Watch), SLCA (Smith Lake Civic Association) and SLEPC (Smith Lake Environmental Protection Committee); and Alabama's Rich Water Resources and AAW.

  19. Analytical Study of Hexapod miRNAs using Phylogenetic Methods

    CERN Document Server

    Mishra, A K

    2012-01-01

    MicroRNAs (miRNAs) are a class of non-coding RNAs that regulate gene expression. Identification of total number of miRNAs even in completely sequenced organisms is still an open problem. However, researchers have been using techniques that can predict limited number of miRNA in an organism. In this paper, we have used homology based approach for comparative analysis of miRNA of hexapoda group .We have used Apis mellifera, Bombyx mori, Anopholes gambiae and Drosophila melanogaster miRNA datasets from miRBase repository. We have done pair wise as well as multiple alignments for the available miRNAs in the repository to identify and analyse conserved regions among related species. Unfortunately, to the best of our knowledge, miRNA related literature does not provide in depth analysis of hexapods. We have made an attempt to derive the commonality among the miRNAs and to identify the conserved regions which are still not available in miRNA repositories. The results are good approximation with a small number of mis...

  20. Hepatitis C virus RNA functionally sequesters miR-122

    Science.gov (United States)

    Luna, Joseph M.; Scheel, Troels K. H.; Danino, Tal; Shaw, Katharina S.; Mele, Aldo; Fak, John J.; Nishiuchi, Eiko; Takacs, Constantin N.; Catanese, Maria Teresa; de Jong, Ype P.; Jacobson, Ira M.; Rice, Charles M.; Darnell, Robert B.

    2015-01-01

    Summary Hepatitis C virus uniquely requires the liver specific microRNA-122 for replication, yet global effects on endogenous miRNA targets during infection are unexplored. Here, high-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) experiments of human Argonaute (Ago) during HCV infection showed robust Ago binding on the HCV 5′UTR, at known and predicted miR-122 sites. On the human transcriptome, we observed reduced Ago binding and functional mRNA de-repression of miR-122 targets during virus infection. This miR-122 “sponge” effect was relieved and redirected to miR-15 targets by swapping the miRNA tropism of the virus. Single-cell expression data from reporters containing miR-122 sites showed significant de-repression during HCV infection depending on expression level and site number. We describe a quantitative mathematical model of HCV induced miR-122 sequestration and propose that such miR-122 inhibition by HCV RNA may result in global de-repression of host miR-122 targets, providing an environment fertile for the long-term oncogenic potential of HCV. PMID:25768906

  1. MicroRNA fate upon targeting with anti-miRNA oligonucleotides as revealed by an improved Northern-blot-based method for miRNA detection

    OpenAIRE

    Torres, Adrian G.; Fabani, Martin M.; Vigorito, Elena; Gait, Michael J.

    2011-01-01

    MicroRNAs (miRNAs) are small non-coding RNAs involved in fine-tuning of gene regulation. Antisense oligonucleotides (ONs) are promising tools as anti-miRNA (anti-miR) agents toward therapeutic applications and to uncover miRNA function. Such anti-miR ONs include 2′-O-methyl (OMe), cationic peptide nucleic acids like K-PNA-K3, and locked nucleic acid (LNA)-based anti-miRs such as LNA/DNA or LNA/OMe. Northern blotting is a widely used and robust technique to detect miRNAs. However, miRNA quanti...

  2. Molecular characterization of the Great Lakes viral hemorrhagic septicemia virus (VHSV isolate from USA

    Directory of Open Access Journals (Sweden)

    Vakharia Vikram N

    2009-10-01

    Full Text Available Abstract Background Viral hemorrhagic septicemia virus (VHSV is a highly contagious viral disease of fresh and saltwater fish worldwide. VHSV caused several large scale fish kills in the Great Lakes area and has been found in 28 different host species. The emergence of VHS in the Great Lakes began with the isolation of VHSV from a diseased muskellunge (Esox masquinongy caught from Lake St. Clair in 2003. VHSV is a member of the genus Novirhabdovirus, within the family Rhabdoviridae. It has a linear single-stranded, negative-sense RNA genome of approximately 11 kbp, with six genes. VHSV replicates in the cytoplasm and produces six monocistronic mRNAs. The gene order of VHSV is 3'-N-P-M-G-NV-L-5'. This study describes molecular characterization of the Great Lakes VHSV strain (MI03GL, and its phylogenetic relationships with selected European and North American isolates. Results The complete genomic sequences of VHSV-MI03GL strain was determined from cloned cDNA of six overlapping fragments, obtained by RT-PCR amplification of genomic RNA. The complete genome sequence of MI03GL comprises 11,184 nucleotides (GenBank GQ385941 with the gene order of 3'-N-P-M-G-NV-L-5'. These genes are separated by conserved gene junctions, with di-nucleotide gene spacers. The first 4 nucleotides at the termini of the VHSV genome are complementary and identical to other novirhadoviruses genomic termini. Sequence homology and phylogenetic analysis show that the Great Lakes virus is closely related to the Japanese strains JF00Ehi1 (96% and KRRV9822 (95%. Among other novirhabdoviruses, VHSV shares highest sequence homology (62% with snakehead rhabdovirus. Conclusion Phylogenetic tree obtained by comparing 48 glycoprotein gene sequences of different VHSV strains demonstrate that the Great Lakes VHSV is closely related to the North American and Japanese genotype IVa, but forms a distinct genotype IVb, which is clearly different from the three European genotypes. Molecular

  3. Genome-wide analysis for discovery of new rice miRNA reveals natural antisense miRNA (nat-miRNAs)

    Science.gov (United States)

    Small RNAs (21-24nt) are involved in gene regulation through translation inhibition, mRNA cleavage, or directing chromatin modifications. In rice, currently ~240 miRNAs have been annotated. We sequenced more than four million small RNAs from rice and identified another 24 miRNA genes. Among these, w...

  4. Aeolian sand preserved in Silver Lake: a new signal of Holocene high stands of Lake Michigan

    Science.gov (United States)

    Fisher, Timothy G.; Loope, Walter L.

    2005-01-01

    Aeolian sand within lake sediment from Silver Lake, Michigan can be used as a proxy for the timing of high lake levels of Lake Michigan.We demonstrate that the sand record from Silver Lake plotted as percent weight is in-phase with the elevation curve of Lake Michigan since the mid-Holocene Nipissing Phase. Because fluctuations in Lake Michigan's lake level are recorded in beach ridges, and are a response to climate change, the aeolian sand record within Silver Lake is also a proxy for climate change. It appears that increases in dune activity and lake sand are controlled by similar climatic shifts that drive fluctuations in lake level of Lake Michigan. High lake levels destabilize coastal bluffs that drive dune sand instability, and along with greater wintertime storminess, increase niveo-aeolian transport of sand across lake ice. The sand is introduced into the lake each spring as the ice cover melts.

  5. Life history of lake herring in Lake Superior

    Science.gov (United States)

    Dryer, William R.; Beil, Joseph

    1964-01-01

    The average annual commercial catch of lake herring (Coregonus artedi) in U.S. waters of Lake Superior was nearly 12 million pounds in 1929-61. This production contributed 62.4 percent of the total U.S. take of lake herring for the Great Lakes. About 90 percent of the annual catch is taken from small-mesh gill nets during the November-December spawning season. The life-history studies were based on 12,187 fish collected in 1950-62; past growth was computed for 3,779 specimens collected from commercial landings at: Duluth, Minn.; Bayfield, Wis.; and Portage Entry and Marquette, Mich.

  6. Lake Kivu, Limnology and Biogeochemistry of a Tropical Great Lake

    OpenAIRE

    2012-01-01

    In the heart of Africa, a unique lake has attracted the attention of scientists since the beginning of the 20th century. At the foot of the Virunga volcano chain, Lake Kivu harbors a vast amount of dissolved carbon dioxide and methane, making it the most dangerous lake on Earth. But the lake also furnishes many goods and services for surrounding populations and may soon become the most important energy supplier in the area. At the beginning of gas exploitation, the time has come to gather the...

  7. Statistical study of geochemistry and mineralogy of uraniferous lake beds in Oligocene Brule Formation in northwestern Nebraska

    International Nuclear Information System (INIS)

    A small area of uranium enrichment is present in an evaporitic lake deposit of the Oligocene Brule Formation about 16 mi northeast of Chadron in northwestern Nebraska. Detrital sediments in the lake beds consist of quartz, feldspar, montmorillonite, illite, and volcanic shards. Minerals precipitated from lake waters are calcite, dolomite, and gypsum; they represent increasing concentration, in that order, of dissolved solids in lake waters. Diagenetic minerals are mainly opal and chalcedony and some calcite, dolomite, and gypsum. Elements mainly associated with detrital sediments include Al, Fe, K, Ti, Na, Li, and Cu. Elements mainly associated with chemical precipitates and diagenetic minerals are Ca, Sr, Si, Mn, and U. Silica and uranium were probably derived from volcanic ash abundant in the sediments. Uranium was deposited in the most evaporitic lake phases. No zeolites or authigenic clay minerals were found in any lake facies. Altered ash beds within the Brule contain abundant authigenic montmorillonitic clay that was apparently reworked before or during lacustrine deposition. Strontium is associated with gypsum and was apparently deposited in that mineral as a substitute for Ca. Uranium is associated with strontium, but probably only because they were both deposited during the most evaporitic periods of lake deposition. Uranium was not linked to any other element in a factor analysis (for four factors), which accounted for only about 27% of the variation in uranium

  8. miR-17-92 Cluster Promotes Cholangiocarcinoma Growth

    Science.gov (United States)

    Zhu, Hanqing; Han, Chang; Lu, Dongdong; Wu, Tong

    2015-01-01

    miR-17-92 is an oncogenic miRNA cluster implicated in the development of several cancers; however, it remains unknown whether the miR-17-92 cluster is able to regulate cholangiocarcinogenesis. This study was designed to investigate the biological functions and molecular mechanisms of the miR-17-92 cluster in cholangiocarcinoma. In situ hybridization and quantitative RT-PCR analysis showed that the miR-17-92 cluster is highly expressed in human cholangiocarcinoma cells compared with the nonneoplastic biliary epithelial cells. Forced overexpression of the miR-17-92 cluster or its members, miR-92a and miR-19a, in cultured human cholangiocarcinoma cells enhanced tumor cell proliferation, colony formation, and invasiveness, in vitro. Overexpression of the miR-17-92 cluster or miR-92a also enhanced cholangiocarcinoma growth in vivo in hairless outbred mice with severe combined immunodeficiency (SHO-PrkdcscidHrhr). The tumor-suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), was identified as a bona fide target of both miR-92a and miR-19a in cholangiocarcinoma cells via sequence prediction, 3′ untranslated region luciferase activity assay, and Western blot analysis. Accordingly, overexpression of the PTEN open reading frame protein (devoid of 3′ untranslated region) prevented miR-92a– or miR-19a–induced cholangiocarcinoma cell growth. Microarray analysis revealed additional targets of the miR-17-92 cluster in human cholangiocarcinoma cells, including APAF-1 and PRDM2. Moreover, we observed that the expression of the miR-17-92 cluster is regulated by IL-6/Stat3, a key oncogenic signaling pathway pivotal in cholangiocarcinogenesis. Taken together, our findings disclose a novel IL-6/Stat3–miR-17-92 cluster–PTEN signaling axis that is crucial for cholangiocarcinogenesis and tumor progression. PMID:25239565

  9. Expression of miR-155 and miR-126 in situ in cutaneous T-cell lymphoma

    DEFF Research Database (Denmark)

    Kopp, Katharina L; Ralfkiaer, Ulrik; Nielsen, Boye S; Gniadecki, Robert; Andersen, Anders Woetmann; Ødum, Niels; Ralfkiaer, Elisabeth

    2013-01-01

    Recently, miR-155 has been implicated in cutaneous T-cell lymphoma (CTCL). Thus, elevated levels of miR-155 were observed in skin lesions from CTCL patients as judged from qPCR and micro-array analysis and aberrant, high miR-155 expression was associated with severe disease. Moreover, miR-155...... promoted proliferation of malignant T cells in vitro. Little is, however, known about which cell types express miR-155 in vivo in CTCL skin lesions. Here, we study miR-155 expression using in situ hybridization (ISH) with a miR-155 probe, a negative control (scrambled), and a miR-126 probe as a positive...... control in nine patients with mycosis fungoides, the most frequent subtype of CTCL. We provide evidence that both malignant and non-malignant T cells stain weakly to moderately positive with the miR-155 probe, but generally negative with the miR-126 and negative control probes. Reversely, endothelial...

  10. MiPS (Mi Prostate Score Urine test) — EDRN Public Portal

    Science.gov (United States)

    The MiPS assay is a multiplex analysis of T2-ERG gene fusion, PCA3, and serum PSA (KLK3). It is commercially available through the University of Michigan MLabs. The MiPS assay tests for the presence of two prostate cancer biomarkers: a piece of RNA made from the PCA3 gene, found to be overactive in 95 percent of all prostate cancers, and another RNA marker that is found only when TMPRSS2 and ERG abnormally fuse. TMPRSS2:ERG, or T2-ERG, is a strong indicator of prostate cancer.

  11. Great Lakes Energy Institute

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, J. Iwan [Case Western Reserve Univ., Cleveland, OH (United States)

    2012-11-18

    The vision of the Great Lakes Energy Institute is to enable the transition to advanced, sustainable energy generation, storage, distribution and utilization through coordinated research, development, and education. The Institute will place emphasis on translating leading edge research into next generation energy technology. The Institute’s research thrusts focus on coordinated research in decentralized power generation devices (e.g. fuel cells, wind turbines, solar photovoltaic devices), management of electrical power transmission and distribution, energy storage, and energy efficiency.

  12. Zooplankton of Lake Kivu

    OpenAIRE

    Darchambeau, François; Isumbisho, Mwapu; Descy, Jean-Pierre

    2012-01-01

    The dominant species of the crustacean plankton in Lake Kivu are the cyclopoid copepods Thermocyclops consimilis and Mesocyclops aequatorialis and the cladoceran Diaphanosoma excisum. Mean crustacean biomass over the period 2003–2004 was 0.99 g C m−2. The seasonal dynamics closely followed variations of chlorophyll a concentration and responded well to the dry season phytoplankton peak. The mean annual crustacean production rate was 23 g C m−2 year−1. The mean trophic transfer efficiency betw...

  13. Bryozoans of Banyoles lake

    OpenAIRE

    Rieradevall i Sant, Maria; Busquets, Josep M.

    1990-01-01

    Data for bryozoan species from Banyoles lake (NE Spain) are presented. Three species have been recorded: Fredericella sultana, Lophopus crystallinus and Plurnatella repens, the first two for the first time in the Iberian peninsula. An examination of the F. sultana colony and the statoblast observations of L. crystallinus and P. repens with the scanning electron rnicroswpe made possible the identification. Details of the floatoblast structure are given.

  14. Lake Urmia is disappearing

    OpenAIRE

    Khatami, Sina

    2015-01-01

    The present article is a translation—to Farsi—of an article by Dr. Ali Mirchi (postdoctoral research associate at the Department of Civil and Environmental Engineering, Michigan Technological University), Dr. Kaveh Madani (lecturer in Environmental Management at the Centre for Environmental Policy, Imperial College London) and Dr. Amir Aghakouchak (assistant professor at the Department of Civil and Environmental Engineering, University of California, Irvine), entitled "Lake Urmia: how Ir...

  15. The Lake Theatre

    OpenAIRE

    Weller, Samantha Joanne

    2015-01-01

    At the beginnings of this thesis, the importance was solely focused on the design of an independent multipurpose theater and the transitions between the public area and backstage. As the year and project progressed, it changed to become a realization and study of architectural experiences within a space. After choosing a site within the Snoqualmie National Forest in Seattle overlooking Lake Serene, decisions were made to design a theater that would not hinder the natural landscape but im...

  16. O desvio do olhar: dos asilos aos museus de arte The deviation of the glance: from the asylums to the art museums

    Directory of Open Access Journals (Sweden)

    João A. Frayze-Pereira

    1999-01-01

    Full Text Available A relação entre a arte e a loucura é considerada do ponto de vista da exposição em museus de arte de obras que foram produzidas nos asilos. Nessa transição, são analisadas a situação historicamente determinada da loucura no campo da visualidade e as implicações culturais, psicológicas e estéticas dessa situação, sobretudo após o advento da noção de art brut. Finalmente, é também considerado o impacto da art brut, como prática dos excluídos sociais, sobre o próprio criador marginal e sobre o olhar do espectador.The relation between art and madness is considered from the point of view of works of art produced in asylums and exhibited in art museums. In this transition, the historically situation of madness is analyzed concerning visual order and it’s cultural, psychological and aesthetic implications in art history, specially after the emergence of the notion of art brut. Finally, it’s also considered the impact of art brut on the outsider artist and on the spectator’s perception.

  17. Bear Lake-Minidoka - Phragmites Control

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Bear Lake: Phragmites patches were sprayed on the refuge & north of the lake proper. Minidoka: patches along the Snake River & Lake Walcott were treated...

  18. Audubon National Wildlife Refuge, Lake Nettie National Wildlife Refuge, Camp Lake Easement Refuge, Wintering River Easement Refuge, Cottonwood Lake Easement Refuge, Sheyenne Lake Easement Refuge : Narrative report : 1969

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Audubon National Wildlife Refuge including Lake Nettie National Wildlife Refuge, Camp Lake Easement Refuge, Cottonwood Lake...

  19. PALEOCLIMATIC CHANGES IN DABUSU LAKE

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Study on the carbonate content and oxygen isotope of a sediment section in Dabusu Lake revealed that this region has experienced several cold-wet and warm-dry climatic cycles since 15400 a BP. It was about 6740 a BP when the climate in the region reached a relatively stable warm stage, so that the lake water was gradually condensed and finally a saline lake was formed.

  20. On China's lake fisheries development

    OpenAIRE

    Wu, W.; Yang, N.; Jin, L.

    1991-01-01

    An account is given of the current situation regarding the lake fisheries and fish culture practices in China. The modern lake fisheries take advantage of the 3-D spaces of lakes to fully develop the resources. Currently, the fisheries concentrate on the following 3 aspects: bringing the water body into full play; various types of aquaculture enclosures; and selective measures in resources protection, stocking and aquaculture.

  1. Surface seiches in Flathead Lake

    OpenAIRE

    G. Kirillin; Lorang, M. S.; T. C. Lippmann; C. C. Gotschalk; S. Schimmelpfennig

    2014-01-01

    Standing surface waves or seiches are inherent hydrodynamic features of enclosed water bodies. Their two-dimensional structure is important for estimating flood risk, coastal erosion and bottom sediment transport and for understanding shoreline habitats and lake ecology in general. In this work, we present analysis of two-dimensional seiche characteristics in Flathead Lake, Montana, USA, a large intermountain lake known to have high seiche amplitudes. To examine spat...

  2. Lake Evaporation: A Model Study

    OpenAIRE

    Amayreh, Jumah

    1995-01-01

    Reliable evaporation data are an essential requirement in any water and/or energy budget studies. This includes operation and management of both urban and agricultural water resources. Evaporation from large, open water surfaces such as lakes and reservoirs may influence many agricultural and irrigation decisions. In this study evaporation from Bear Lake in the states of Idaho and Utah was measured using advanced research instruments (Bowen Ratio and Eddy Correlation). Actual over-lake evapor...

  3. Resilience and Restoration of Lakes

    OpenAIRE

    Cottingham, Kathryn L.; Carpenter, Stephen R.

    1997-01-01

    Lake water quality and ecosystem services are normally maintained by several feedbacks. Among these are nutrient retention and humic production by wetlands, nutrient retention and woody habitat production by riparian forests, food web structures that cha nnel phosphorus to consumers rather than phytoplankton, and biogeochemical mechanisms that inhibit phosphorus recycling from sediments. In degraded lakes, these resilience mechanisms are replaced by new ones that connect lakes to larger, regi...

  4. miRBase Tracker: keeping track of microRNA annotation changes

    OpenAIRE

    Van Peer, Gert; Lefever, Steve; Anckaert, Jasper; Beckers, Anneleen; Rihani, Ali; Van Goethem, Alan; Volders, Pieter-Jan; Zeka, Fjoralba; Ongenaert, Maté; Mestdagh, Pieter; Vandesompele, Jo

    2014-01-01

    Since 2002, information on individual microRNAs (miRNAs), such as reference names and sequences, has been stored in miRBase, the reference database for miRNA annota- tion. As a result of progressive insights into the miRNome and its complexity, miRBase underwent addition and deletion of miRNA records, changes in annotated miRNA se- quences and adoption of more complex naming schemes over time. Unfortunately, miRBase does not allow straightforward assessment of these ongoing miRNA annota- tion...

  5. The MiPACQ Clinical Question Answering System

    OpenAIRE

    Cairns, Brian L.; Nielsen, Rodney D; Masanz, James J.; Martin, James H.; Palmer, Martha S.; Ward, Wayne H.; Savova, Guergana K

    2011-01-01

    The Multi-source Integrated Platform for Answering Clinical Questions (MiPACQ) is a QA pipeline that integrates a variety of information retrieval and natural language processing systems into an extensible question answering system. We present the system’s architecture and an evaluation of MiPACQ on a human-annotated evaluation dataset based on the Medpedia health and medical encyclopedia. Compared with our baseline information retrieval system, the MiPACQ rule-based system demonstrates 84% i...

  6. miRNA-target prediction based on transcriptional regulation

    Directory of Open Access Journals (Sweden)

    Fujiwara Toyofumi

    2013-02-01

    Full Text Available Abstract Background microRNAs (miRNAs are tiny endogenous RNAs that have been discovered in animals and plants, and direct the post-transcriptional regulation of target mRNAs for degradation or translational repression via binding to the 3'UTRs and the coding exons. To gain insight into the biological role of miRNAs, it is essential to identify the full repertoire of mRNA targets (target genes. A number of computer programs have been developed for miRNA-target prediction. These programs essentially focus on potential binding sites in 3'UTRs, which are recognized by miRNAs according to specific base-pairing rules. Results Here, we introduce a novel method for miRNA-target prediction that is entirely independent of existing approaches. The method is based on the hypothesis that transcription of a miRNA and its target genes tend to be co-regulated by common transcription factors. This hypothesis predicts the frequent occurrence of common cis-elements between promoters of a miRNA and its target genes. That is, our proposed method first identifies putative cis-elements in a promoter of a given miRNA, and then identifies genes that contain common putative cis-elements in their promoters. In this paper, we show that a significant number of common cis-elements occur in ~28% of experimentally supported human miRNA-target data. Moreover, we show that the prediction of human miRNA-targets based on our method is statistically significant. Further, we discuss the random incidence of common cis-elements, their consensus sequences, and the advantages and disadvantages of our method. Conclusions This is the first report indicating prevalence of transcriptional regulation of a miRNA and its target genes by common transcription factors and the predictive ability of miRNA-targets based on this property.

  7. Association of miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms with Ossification of the Posterior Longitudinal Ligament of the Cervical Spine

    Science.gov (United States)

    Jeon, Young Joo; Kumar, Hemant; Sohn, Seil; Min, Hyoung Sik; Lee, Jang Bo; Kuh, Sung Uk; Kim, Keung Nyun; Kim, Jung Oh; Kim, Ok Joon; Ropper, Alexander E.; Kim, Nam Keun; Han, In Bo

    2016-01-01

    Background Ossification of the posterior longitudinal ligament (OPLL) of the spine is considered a multifactorial and polygenic disease. We aimed to investigate the association between four single nucleotide polymorphisms (SNPs) of pre-miRNAs [miR-146aC>G (rs2910164), miR-149T>C (rs2292832), miR-196a2T>C (rs11614913), and miR-499A>G (rs3746444)] and the risk of cervical OPLL in the Korean population. Methods The genotypic frequencies of these four SNPs were analyzed in 207 OPLL patients and 200 controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Findings For four SNPs in pre-miRNAs, no significant differences were found between OPLL patients and controls. However, subgroup analysis based on OPLL subgroup (continuous: continuous type plus mixed type, segmental: segmental and localized type) showed that miR-499GG genotype was associated with an increased risk of segmental type OPLL (adjusted odds ratio = 4.314 with 95% confidence interval: 1.109–16.78). In addition, some allele combinations (C-T-T-G, G-T-T-A, and G-T-C-G of miR-146a/-149/-196a2/-499) and combined genotypes (miR-149TC/miR-196a2TT) were associated with increased OPLL risk, whereas the G-T-T-G and G-C-C-G allele combinations were associated with decreased OPLL risk. Conclusion The results indicate that GG genotype of miR-499 is associated with significantly higher risks of OPLL in the segmental OPLL group. The miR-146a/-149/-196a2/-499 allele combinations may be a genetic risk factor for cervical OPLL in the Korean population. PMID:27454313

  8. Association between single nucleotide polymorphism in miR-499, miR-196a2, miR-146a and miR-149 and prostate cancer risk in a sample of Iranian population.

    Science.gov (United States)

    Hashemi, Mohammad; Moradi, Nazanin; Ziaee, Seyed Amir Mohsen; Narouie, Behzad; Soltani, Mohammad Hosein; Rezaei, Maryam; Shahkar, Ghazaleh; Taheri, Mohsen

    2016-05-01

    MicroRNAs (miRNAs) play an important role in regulating gene expression at the post-transcriptional level and are involved in numerous physiological processes. Accumulating evidence suggests that single-nucleotide polymorphisms (SNPs) in human miRNA genes may affect miRNA biogenesis pathway and influence the susceptibility to several diseases such as cancer. The present study aimed to evaluate the impact of miR-499 rs3746444, miR-196a2 rs11614913, miR-149 rs2292832, and miR-146a rs2910164 polymorphisms on prostate cancer (PCa) risk in a sample of Iranian population. This case-control study was done on 169 patients with pathologically confirmed PCa and 182 benign prostatic hyperplasia (BPH). The genotyping assays were done using T-ARMS-PCR or PCR-RFLP methods. The findings indicated that CC genotype of miR-499 rs3746444 polymorphism increased the risk of PCa (OR = 1.76, 95% CI = 1.12-2.79, P = 0.019) compared to TT genotype. No statistically significant association was found between miR-196a2 rs11614913, miR-149 rs2292832, and miR-146a rs2910164 polymorphisms and PCa risk. In summary, the findings indicated that miR-499 rs3746444 polymorphism increased the risk of PCa in an Iranian population. Further studies with larger sample sizes and different ethnicities are necessary to verify the findings of the present study. PMID:27222754

  9. Algae Bloom in a Lake

    Directory of Open Access Journals (Sweden)

    David Sanabria

    2008-01-01

    Full Text Available The objective of this paper is to determine the likelihood of an algae bloom in a particular lake located in upstate New York. The growth of algae in this lake is caused by a high concentration of phosphorous that diffuses to the surface of the lake. Our calculations, based on Fick's Law, are used to create a mathematical model of the driving force of diffusion for phosphorous. Empirical observations are also used to predict whether the concentration of phosphorous will diffuse to the surface of this lake within a specified time and under specified conditions.

  10. Glacial lakes Buni and Jezerce: Albania

    OpenAIRE

    Milivojević Milovan; Kovačević-Majkić Jelena

    2005-01-01

    The paper presents glacial lakes and glacial relief forms at the foothill of the peak Maja Jezerce in Mt. Prokletije in Albania, near the border with Montenegro. The group of lakes Buni and Jezerce, which consists of six lakes and which genetically belongs to glacial-erosional lakes, is analyzed. Lakes are situated at the cirque bottom, between the moraines and limestone ridges. Except presented morphometric characteristics of lake basins, data about cirque are given, as well as the reconstru...

  11. THE LAKES IN ROMANIA - AN ACTUAL SYNTHESIS

    OpenAIRE

    Petre GÂŞTESCU

    2010-01-01

    The article offers a synthesis of the lakes of Romania. We addressed the following questions: genetic types of lakes, geographical distribution and their use in various fields of activities. Thus, in the territory of Romania is a large genetic diversity of lakes distributed on all major forms of relief and recovery in many economic areas. Romania is particularly present fluvial lakes, glacial lakes and anthropogenic lakes (especially reservoirs).

  12. UMTRA project water sampling and analysis plan, Ambrosia Lake, New Mexico

    International Nuclear Information System (INIS)

    This water sampling and analysis plan (WSAP) provides the basis for ground water sampling at the Ambrosia Lake Uranium Mill Tailings Remedial Action (UMTRA) Project site during fiscal year 1994. It identifies and justifies the sampling locations, analytical parameters, detection limits, and sampling frequency for the monitoring locations and will be updated annually. The Ambrosia Lake site is in McKinley County, New Mexico, about 40 kilometers (km) (25 miles [mi]) north of Grants, New Mexico, and 1.6 km (1 mi) east of New Mexico Highway 509 (Figure 1.1). The town closest to the tailings pile is San Mateo, about 16 km ( 10 mi) southeast (Figure 1.2). The former mill and tailings pile are in Section 28, and two holding ponds are in Section 33, Township 14 North, Range 9 West. The site is shown on the US Geological Survey (USGS) map (USGS, 1980). The site is approximately 2100 meters (m) (7000 feet [ft]) above sea level

  13. UMTRA project water sampling and analysis plan, Ambrosia Lake, New Mexico

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    This water sampling and analysis plan (WSAP) provides the basis for ground water sampling at the Ambrosia Lake Uranium Mill Tailings Remedial Action (UMTRA) Project site during fiscal year 1994. It identifies and justifies the sampling locations, analytical parameters, detection limits, and sampling frequency for the monitoring locations and will be updated annually. The Ambrosia Lake site is in McKinley County, New Mexico, about 40 kilometers (km) (25 miles [mi]) north of Grants, New Mexico, and 1.6 km (1 mi) east of New Mexico Highway 509 (Figure 1.1). The town closest to the tailings pile is San Mateo, about 16 km ( 10 mi) southeast (Figure 1.2). The former mill and tailings pile are in Section 28, and two holding ponds are in Section 33, Township 14 North, Range 9 West. The site is shown on the US Geological Survey (USGS) map (USGS, 1980). The site is approximately 2100 meters (m) (7000 feet [ft]) above sea level.

  14. Isolation and Identification of miRNAs in Jatropha curcas

    Directory of Open Access Journals (Sweden)

    Chun Ming Wang, Peng Liu, Fei Sun, Lei Li, Peng Liu, Jian Ye, Gen Hua Yue

    2012-01-01

    Full Text Available MicroRNAs (miRNAs are small noncoding RNAs that play crucial regulatory roles by targeting mRNAs for silencing. To identify miRNAs in Jatropha curcas L, a bioenergy crop, cDNA clones from two small RNA libraries of leaves and seeds were sequenced and analyzed using bioinformatic tools. Fifty-two putative miRNAs were found from the two libraries, among them six were identical to known miRNAs and 46 were novel. Differential expression patterns of 15 miRNAs in root, stem, leave, fruit and seed were detected using quantitative real-time PCR. Ten miRNAs were highly expressed in fruit or seed, implying that they may be involved in seed development or fatty acids synthesis in seed. Moreover, 28 targets of the isolated miRNAs were predicted from a jatropha cDNA library database. The miRNA target genes were predicted to encode a broad range of proteins. Sixteen targets had clear BLASTX hits to the Uniprot database and were associated with genes belonging to the three major gene ontology categories of biological process, cellular component, and molecular function. Four targets were identified for JcumiR004. By silencing JcumiR004 primary miRNA, expressions of the four target genes were up-regulated and oil composition were modulated significantly, indicating diverse functions of JcumiR004.

  15. miR-1279, miR-548j, miR-548m, and miR-548d-5p Binding Sites in CDSs of Paralogous and Orthologous PTPN12, MSH6, and ZEB1 Genes

    Directory of Open Access Journals (Sweden)

    Anatoliy T. Ivashchenko

    2013-01-01

    Full Text Available Only PTPN12, MSH6, and ZEB1 have significant miR-1279 binding sites among paralogous genes of human tyrosine phosphatase family, DNA mismatch repair family, and zinc finger family, respectively. All miRNA binding sites are located within CDSs of studied mRNAs. Nucleotide sequences of hsa-miR-1279 binding sites with mRNAs of human PTPN12, MSH6, and ZEB1 genes encode TKEQYE, EGSSDE, and GEKPYE oligopeptides, respectively. The conservation of miRNA binding sites encoding oligopeptides has been revealed. MRNAs of many paralogs of zinc finger gene family have from 1 to 12 binding sites coding the same GEKPYE hexapeptide. MRNAs of PTPN12, MSH6, and ZEB1 orthologous genes from different animal species have binding sites for hsa-miR-1279 which consist of homologous oligonucleotides encoding similar human oligopeptides TKEQYE, EGSSDE, and GEKPYE. MiR-548j, miR-548m, and miR-548d-5p have homologous binding sites in the mRNA of PTPN12 orthologous genes which encode PRTRSC, TEATDI, and STASAT oligopeptides, respectively. All regions of miRNA are important for binding with the mRNA.

  16. MicroRNA miR-125b causes leukemia

    OpenAIRE

    Bousquet, Marina; Harris, Marian H.; Zhou, Beiyan; Lodish, Harvey F.

    2010-01-01

    MicroRNA miR-125b has been implicated in several kinds of leukemia. The chromosomal translocation t(2;11)(p21;q23) found in patients with myelodysplasia and acute myeloid leukemia leads to an overexpression of miR-125b of up to 90-fold normal. Moreover, miR-125b is also up-regulated in patients with B-cell acute lymphoblastic leukemia carrying the t(11;14)(q24;q32) translocation. To decipher the presumed oncogenic mechanism of miR-125b, we used transplantation experiments in mice. All mice tr...

  17. Exosomal miRNAs as cancer biomarkers and therapeutic targets

    OpenAIRE

    Arron Thind; Clive Wilson

    2016-01-01

    Intercommunication between cancer cells and with their surrounding and distant environments is key to the survival, progression and metastasis of the tumour. Exosomes play a role in this communication process. MicroRNA (miRNA) expression is frequently dysregulated in tumour cells and can be reflected by distinct exosomal miRNA (ex-miRNA) profiles isolated from the bodily fluids of cancer patients. Here, the potential of ex-miRNA as a cancer biomarker and therapeutic target is critically analy...

  18. MICRORNAs: miRRORS OF HEALTH AND DISEASE

    OpenAIRE

    Montano, Monty

    2011-01-01

    The review articles in this issue provide an improved appreciation for miRNA as an essential feature of lineage commitment and regulatory guidance during tissue development, that when absent or hampered, often lead to disease states. In the coming years, there is much to be learned about adaptive (and maladaptive) states by examining how expression of miRNAs is influenced by the genetic architecture of miR genes, clusters and mirtrons, as well as miRNA polymorphism and polymorphism in their m...

  19. Progress in miRNA target prediction and identification

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Recently, the identification of miRNA targets has received much attention. The strategies to determine miRNA targets include bioinformatic prediction and experimental assays. The bioinformatic prediction methods are mainly based on the confirmed rules of interaction between miRNAs and their targets, and are carried out by programs, such as miRanda, TargetScan, TargetScanS, RNAhybrid, DIANA-microT, PicTar, RNA22 and FindTar, which follow well-known principles. The experimental assays to find miRNA targets employ immunoprecipitation of AGO proteins to identify interacting mRNAs, or the analysis of mRNA or protein levels to identify genes which can be regulated by miRNAs. The improvement of current bioinformatic and experimental assays and the development of novel assays will enable greater efficiency in the identification of miRNA targets and thus facilitate miRNA research. This paper describes progress in the prediction and identification of miRNA targets.

  20. Lake Charles CCS Project

    Energy Technology Data Exchange (ETDEWEB)

    Leib, Thomas [Leucadia Energy, LLC, Salt Lake City, UT (United States); Cole, Dan [Denbury Onshore, LLC, Plano, TX (United States)

    2015-06-30

    In late September 2014 development of the Lake Charles Clean Energy (LCCE) Plant was abandoned resulting in termination of Lake Charles Carbon Capture and Sequestration (CCS) Project which was a subset the LCCE Plant. As a result, the project was only funded through Phase 2A (Design) and did not enter Phase 2B (Construction) or Phase 2C (Operations). This report was prepared relying on information prepared and provided by engineering companies which were engaged by Leucadia Energy, LLC to prepare or review Front End Engineering and Design (FEED) for the Lake Charles Clean Energy Project, which includes the Carbon Capture and Sequestration (CCS) Project in Lake Charles, Louisiana. The Lake Charles Carbon Capture and Sequestration (CCS) Project was to be a large-scale industrial CCS project intended to demonstrate advanced technologies that capture and sequester carbon dioxide (CO2) emissions from industrial sources into underground formations. The Scope of work was divided into two discrete sections; 1) Capture and Compression prepared by the Recipient Leucadia Energy, LLC, and 2) Transport and Sequestration prepared by sub-Recipient Denbury Onshore, LLC. Capture and Compression-The Lake Charles CCS Project Final Technical Report describes the systems and equipment that would be necessary to capture CO2 generated in a large industrial gasification process and sequester the CO2 into underground formations. The purpose of each system is defined along with a description of its equipment and operation. Criteria for selection of major equipment are provided and ancillary utilities necessary for safe and reliable operation in compliance with environmental regulations are described. Construction considerations are described including a general arrangement of the CCS process units within the overall gasification project. A cost estimate is provided, delineated by system area with cost breakdown showing equipment, piping and materials