WorldWideScience

Sample records for asthma research program

  1. Asthma Research: The NIH–NJRC Connection

    Science.gov (United States)

    ... early life exposures to allergens may help protect children from asthma. Some of NJRC's most important research addresses the ... story. ) In pediatric asthma, doctors are studying and treating the progression of asthma, infant wheezing that leads to asthma, and severe ...

  2. Asthma in Adolescents: A Randomized, Controlled Trial of an Asthma Program for Adolescents and Young Adults with Severe Asthma

    OpenAIRE

    Robert L Cowie; Underwood, Margot F; Little, Cinde B; Ian Mitchell; Sheldon Spier; Ford, Gordon T

    2002-01-01

    BACKGROUND: Asthma is common and is often poorly controlled in adolescent subjects.OBJECTIVE: To determine the impact of an age-specific asthma program on asthma control, particularly on exacerbations of asthma requiring emergency department treatment, and on the quality of life of adolescents with asthma.METHODS: The present randomized, controlled trial included patients who were 15 to 20 years of age and had visited emergency departments for management of their asthma. The interventional gr...

  3. Evaluation of an Educational Program for Adolescents with Asthma

    Science.gov (United States)

    Berg, Jill; Tichacek, Mary J.; Theodorakis, Renee

    2004-01-01

    In addition to challenges of adolescence itself, teens with asthma face demands of asthma management and risks of asthma sequelae, including fatalities. Few asthma educational programs specifically address their needs. In response to school nurse concern, this pilot study evaluated an adolescent asthma education program, the "Power Breathing[TM]…

  4. Researching asthma across the ages: Insights from the NHLBI Asthma Network

    OpenAIRE

    Cabana, Michael D; Kunselman, Susan J.; Nyenhuis, Sharmilee; Wechsler, Michael E.

    2014-01-01

    Clinical asthma studies across different age groups, or ‘cross-age’ studies, can potentially offer insight into the similarities, differences and relationships between childhood and adult asthma. The National Institutes of Health Asthma Research Network (AsthmaNet) is unique and innovative in that it has merged pediatric and adult asthma research into one clinical research network. This combination enhances scientific exchange between pediatric and adult asthma investigators and encourages th...

  5. Leveraging Mobile Technology in a School-Based Participatory Asthma Intervention: Findings from the Student Media-Based Asthma Research Team (SMART) Study

    Science.gov (United States)

    Warren, Christopher M.; Dyer, Ashley; Blumenstock, Jesse; Gupta, Ruchi S.

    2016-01-01

    Background: Asthma places a heavy burden on Chicago's schoolchildren, particularly in low-income, minority communities. Recently, our group developed a 10-week afterschool program, the Student Asthma Research Team (START), which successfully engaged high school youth in a Photovoice investigation of factors impacting their asthma at school and in…

  6. Asthma: NIH-Sponsored Research and Clinical Trials | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... of this page please turn Javascript on. Feature: Asthma Asthma: NIH-Sponsored Research and Clinical Trials Past Issues / Fall 2011 Table of Contents NIH-Sponsored Research Asthma in the Inner City: Recognizing that asthma severity ...

  7. National Asthma Control Program State Profiles

    Science.gov (United States)

    ... physicians' office Health care providers - Medical clinics/physicians' office Health care providers - Other Parents - Home Case Studies Open Airways for Schools Asthma Care Training Wee Wheezers ...

  8. The Awesome Asthma School Days Program: Educating Children, Inspiring a Community.

    Science.gov (United States)

    Meurer, John R.; McKenzie, Sue; Mischler, Elaine; Subichin, Steve; Malloy, Marsha; George, Varghese

    1999-01-01

    Elementary students with asthma from 74 Milwaukee schools participated in the Awesome Asthma School Day program to improve their health. Pre- and post-program surveys indicated that participants lived with many asthma-related problems and lacked asthma self-care tools. The program improved their expectations about play and sleep and their…

  9. Future Research Directions in Asthma. An NHLBI Working Group Report.

    Science.gov (United States)

    Levy, Bruce D; Noel, Patricia J; Freemer, Michelle M; Cloutier, Michelle M; Georas, Steve N; Jarjour, Nizar N; Ober, Carole; Woodruff, Prescott G; Barnes, Kathleen C; Bender, Bruce G; Camargo, Carlos A; Chupp, Geoff L; Denlinger, Loren C; Fahy, John V; Fitzpatrick, Anne M; Fuhlbrigge, Anne; Gaston, Ben M; Hartert, Tina V; Kolls, Jay K; Lynch, Susan V; Moore, Wendy C; Morgan, Wayne J; Nadeau, Kari C; Ownby, Dennis R; Solway, Julian; Szefler, Stanley J; Wenzel, Sally E; Wright, Rosalind J; Smith, Robert A; Erzurum, Serpil C

    2015-12-01

    Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the NHLBI convened a group of extramural investigators for an Asthma Research Strategic Planning workshop on September 18-19, 2014, to accelerate discoveries and their translation to patients. The workshop focused on (1) in utero and early-life origins of asthma, (2) the use of phenotypes and endotypes to classify disease, (3) defining disease modification, (4) disease management, and (5) implementation research. This report summarizes the workshop and produces recommendations to guide future research in asthma. PMID:26305520

  10. Research on psychosocial aspects of asthma in the Arab world: a literature review.

    Science.gov (United States)

    Al-Khateeb, Anas J; Al Khateeb, Jamal M

    2015-01-01

    The importance of psychosocial factors in the management of bronchial asthma has long been recognized. This paper offers a review of research published in the English language related to psychosocial aspects of bronchial asthma in Arab countries. Several databases (PubMed, Science Direct, Springer Link, ERIC, and PsychInfo) were searched using the following keywords: bronchial asthma, Arab countries, Algiers, Bahrain, Comoros, Djibouti, Egypt, Iraq, Jordan, Kuwait, Lebanon, Libya, Mauritania, Morocco, Oman, Palestine (West Bank, Gaza), Qatar, Saudi Arabia, Syria, Tunisia, Sudan, Somalia; United Arab Emirates, and Yemen. Thirty-two studies were conducted in 9 Arab countries. Almost all studies found were published in the last fourteen years with an apparent increasing rate in the last five years. In descending order, these studies addressed: knowledge of and attitudes toward asthma, quality of life, behavioral and emotional problems and factors related to academic achievement. The main results of the studies reviewed were: (a) physicians', school staff's, and parents' knowledge of and attitudes toward asthma were generally unsatisfactory, (b) in-service asthma education programs significantly impacted parent and staff knowledge and attitudes, and asthma management practices, (c) quality of life in children and adolescents was significantly adversely affected by asthma, (d) asthma was a common cause of school absenteeism, and had a significant negative impact on academic achievement of students, and (e) students with asthma had significantly higher rates of behavioral and emotional difficulties compared to students without asthma. The paper concludes with a discussion about the implications of these results and a call for further research in this area.

  11. Efficacy of the I Can Control Asthma and Nutrition Now (ICAN) Pilot Program on Health Outcomes in High School Students with Asthma

    Science.gov (United States)

    Kouba, Joanne; Velsor-Friedrich, Barbarba; Militello, Lisa; Harrison, Patrick R.; Becklenberg, Amy; White, Barb; Surya, Shruti; Ahmed, Avais

    2013-01-01

    Asthma is the most prevalent chronic illness in childhood affecting 7 million youth. Many youth with asthma face another risk factor in obesity. Obesity, in turn, increases disorders such as asthma. Studies have recommended that asthma programs also address weight management in youth. Taking this into consideration, the I Can Control Asthma and…

  12. Asthma

    Science.gov (United States)

    ... it as a kid. What Causes an Asthma Flare-Up? Anything that causes an asthma flare-up (attack) is called an asthma trigger. Different kids ... doctor will think about what causes the asthma flare-ups, how fast the flare-ups happen, and how ...

  13. Asthma

    Science.gov (United States)

    ... by allergens or physical activity. Occasionally, doctors use X-rays to diagnose asthma. Doctors treat each asthma case ... them. If you get flare-ups during a game or workout, stop what you're doing until ...

  14. Asthma

    Directory of Open Access Journals (Sweden)

    Kim Harold

    2011-11-01

    Full Text Available Abstract Asthma is the most common respiratory disorder in Canada. Despite significant improvement in the diagnosis and management of this disorder, the majority of Canadians with asthma remain poorly controlled. In most patients, however, control can be achieved through the use of avoidance measures and appropriate pharmacological interventions. Inhaled corticosteroids (ICSs represent the standard of care for the majority of patients. Combination ICS/long-acting beta2-agonists (LABA inhalers are preferred for most adults who fail to achieve control with ICS therapy. Allergen-specific immunotherapy represents a potentially disease-modifying therapy for many patients with asthma, but should only be prescribed by physicians with appropriate training in allergy. Regular monitoring of asthma control, adherence to therapy and inhaler technique are also essential components of asthma management. This article provides a review of current literature and guidelines for the appropriate diagnosis and management of asthma.

  15. Asthma Is More Severe in Older Adults

    OpenAIRE

    Zein, Joe G.; Dweik, Raed A.; Comhair, Suzy A.; Bleecker, Eugene R.; Moore, Wendy C.; Peters, Stephen P.; Busse, William W.; Jarjour, Nizar N.; Calhoun, William J.; Castro, Mario; Chung, K. Fan; Fitzpatrick, Anne; Israel, Elliot; Teague, W. Gerald; Sally E. Wenzel

    2015-01-01

    Background: Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration. Methods: This is a cross-sectional study of prospectively collected data from adult participants (N=1130; 454 with severe asthma) enrolled from 2002 – 2011 in the Severe Asthma Research Program. Results: The association between age and the probability of severe asthma, which was performed by ap...

  16. The Program for the Prevention of Childhood Asthma: a specialized care program for children with wheezing or asthma in Brazil

    Science.gov (United States)

    Urrutia-Pereira, Marilyn; Avila, Jennifer; Solé, Dirceu

    2016-01-01

    Objective : To present the Programa Infantil de Prevenção de Asma (PIPA, Program for the Prevention of Childhood Asthma) and the characteristics of the patients followed in this program. Methods : Implemented in the city of Uruguaiana, Brazil, PIPA has as its target population children and adolescents ( 3 years of age, respectively. Physician-diagnosed asthma was reported in 26.5% and 82.2%, respectively. In the sample as a whole, the prevalence of passive smoking was high (> 36%), occurring during pregnancy in > 15%; > 40% of the patients had been born by cesarean section; and 30% had a mother who had had < 8 years of schooling. Conclusions : A prevention program for children with asthma is an effective strategy for controlling the disease. Knowledge of local epidemiological and environmental characteristics is essential to reducing the prevalence of the severe forms of asthma, to improving the use of health resources, and to preventing pulmonary changes that could lead to COPD in adulthood. PMID:26982040

  17. New ideas in asthma and allergy research: creating a multidisciplinary graduate school

    OpenAIRE

    Björkstén, Bengt; Graninger, Göran; Ekman, Gunilla Jacobsson

    2003-01-01

    The spring term of 2001 saw the start of a new, unique graduate research training program at the Centre for Allergy Research at the Karolinska Institutet in Stockholm, Sweden. The program was created to bridge the gaps between basic, clinical, social, and behavioral sciences and to establish a global approach to the study of asthma and allergy. A reflection, two years on, discusses the strategies that are key to this model’s success and the challenges in introducing a multidisciplinary resear...

  18. Asthma and Allergy Foundation of America

    Science.gov (United States)

    ... Researchers & Academics Sponsors & Supporters Donate Contact AAFA Asthma Asthma Triggers Allergens and Allergic Asthma Tobacco Smoke Air Pollution ... Feed Subscribe Asthma Capitals Asthma Facts Asthma Research Asthma Triggers Allergy Capitals Allergy Facts Allergy Research Allergy Treatment ...

  19. Pediatric Asthma

    Science.gov (United States)

    ... MD Dept. of Pediatrics View full profile Pediatric Asthma: Overview For some children with asthma, their first ... Calendar Read the News View Daily Pollen Count Asthma Treatment Program At National Jewish Health, we offer ...

  20. [Asthma Update 2015--What Cell Biology in Basic Pulmonary Research Can Offer to the Pneumologist].

    Science.gov (United States)

    Wegmann, M; Fehrenbach, H; Krauss-Etschmann, S

    2016-02-01

    Bronchial asthma is one of the most common chronic inflammatory diseases world-wide causing an enormous socio-economic burden especially in industrialized countries. Currently, asthma is increasingly considered to be a poly-symptomatic disease comprising a variety of different asthma phenotypes and endotypes. This heterogeneity of asthma explains why the standard treatment with corticosteroids and β-agonists cannot achieve full symptom control in all cases, especially not during acute exacerbations. Therefore, current asthma research focuses on primary prevention of asthma as well as on novel approaches towards a phenotype- and endotype-specific asthma therapy.

  1. A Randomized Controlled Trial of a Public Health Nurse-Delivered Asthma Program to Elementary Schools

    Science.gov (United States)

    Cicutto, Lisa; To, Teresa; Murphy, Suzanne

    2013-01-01

    Background: Childhood asthma is a serious and common chronic disease that requires the attention of nurses and other school personnel. Schools are often the first setting that children take the lead in managing their asthma. Often, children are ill prepared for this role. Our study evaluated a school-based, multifaceted asthma program that…

  2. The innovation journey of genomics and asthma research.

    Science.gov (United States)

    Bitsch, Lise; Stemerding, Dirk

    2013-11-01

    This article concerns the transformative potential of medical genomics for common disease research. We analysed 13 review articles in asthma research in the period 1999 to 2008. Our aim was to understand how genomics has emerged in this research field, and the attendant changes. Motivated by Lippman's geneticisation thesis, we use the concept of an 'innovation journey' to trace how expectations of improved understanding, prevention, diagnosis and treatment structure a dynamic co-evolutionary process through which a genome-based discourse emerges. We show how the asthma researchers involved continuously struggle to define their contribution to asthma research, as well as to clinical practice. Along the way, the researchers propose changes to both the definition and the aetiological model of asthma, thus highlighting gene-gene and gene-environment interactions. It is, however, difficult to characterise this discourse as one of geneticisation. With increasing attention being given to epigenetics, metabolomics, proteomics and systems biology, the emerging picture suggests an important, but much less deterministic, role for genes.

  3. Comparative effectiveness of asthma interventions within a practice based research network

    Directory of Open Access Journals (Sweden)

    Hebert Lisa

    2011-08-01

    Full Text Available Abstract Background Asthma is a chronic lung disease that affects more than 23 million people in the United States, including 7 million children. Asthma is a difficult to manage chronic condition associated with disparities in health outcomes, poor medical compliance, and high healthcare costs. The research network coordinating this project includes hospitals, urgent care centers, and outpatient clinics within Carolinas Healthcare System that share a common electronic medical record and billing system allowing for rapid collection of clinical and demographic data. This study investigates the impact of three interventions on clinical outcomes for patients with asthma. Interventions are: an integrated approach to care that incorporates asthma management based on the chronic care model; a shared decision making intervention for asthma patients in underserved or disadvantaged populations; and a school based care approach that examines the efficacy of school-based programs to impact asthma outcomes including effectiveness of linkages between schools and the healthcare providers. Methods/Design This study will include 95 Practices, 171 schools, and over 30,000 asthmatic patients. Five groups (A-E will be evaluated to determine the effectiveness of three interventions. Group A is the usual care control group without electronic medical record (EMR. Group B practices are a second control group that has an EMR with decision support, asthma action plans, and population reports at baseline. A time delay design during year one converts practices in Group B to group C after receiving the integrated approach to care intervention. Four practices within Group C will receive the shared decision making intervention (and become group D. Group E will receive a school based care intervention through case management within the schools. A centralized database will be created with the goal of facilitating comparative effectiveness research on asthma outcomes

  4. Comparative Effectiveness on Cognitive Asthma Outcomes of the SHARP Academic Asthma Health Education and Counseling Program and a Non-Academic Program.

    Science.gov (United States)

    Kintner, Eileen; Cook, Gwendolyn; Marti, C Nathan; Stoddard, Debbie; Gomes, Melissa; Harmon, Phyllis; Van Egeren, Laurie A

    2015-12-01

    Asthma morbidity and mortality is higher among older school-age children and early adolescents than other age groups across the lifespan. NIH recommended expanding asthma education to schools and community settings to meet cognitive outcomes that have an impact on morbidity and mortality. Guided by the acceptance of asthma model, an evidence-guided, comprehensive school-based academic health education and counseling program, Staying Healthy-Asthma Responsible & Prepared™ (SHARP), was developed. The program complements existing school curricula by integrating biology, psychology, and sociology content with related spelling, math, and reading and writing assignments. Feasibility, benefits, and efficacy have been established. We compared the effectiveness of SHARP to a non-academic program, Open Airways for Schools, in improving asthma knowledge and reasoning about symptom management. A two-group, cluster-randomized, single-blinded design was used with a sample of 205 students in grades 4-5 with asthma and their caregivers. Schools were matched prior to randomization. The unit of analysis was the student. Certified elementary school teachers delivered the programs during instructional time. Data were collected from student/caregiver dyads at baseline and at 1, 12, and 24 months after the intervention. In multilevel modeling, students enrolled in the academic SHARP program demonstrated significant (pasthma knowledge and reasoning over students enrolled in the non-academic program. Knowledge advantages were retained at 24 months. Findings support delivery in schools of the SHARP academic health education program for students with asthma.

  5. Asthma Risk Profiles of Children Participating in an Asthma Education and Management Program

    Science.gov (United States)

    Wilson, Candice; Rapp, Kristi Isaac; Jack, Leonard, Jr.; Hayes, Sandra; Post, Robert; Malveaux, Floyd

    2015-01-01

    Background: Focused risk assessment is essential in the effective management of asthma. Purpose: This study identified and examined correlations among areas of pediatric asthma risk and determined associations between these risks and demographic characteristics. Methods: This exploratory study identified risk factors that affect asthma management…

  6. Comparative Effectiveness on Cognitive Asthma Outcomes of the SHARP Academic Asthma Health Education and Counseling Program and a Non-Academic Program.

    Science.gov (United States)

    Kintner, Eileen; Cook, Gwendolyn; Marti, C Nathan; Stoddard, Debbie; Gomes, Melissa; Harmon, Phyllis; Van Egeren, Laurie A

    2015-12-01

    Asthma morbidity and mortality is higher among older school-age children and early adolescents than other age groups across the lifespan. NIH recommended expanding asthma education to schools and community settings to meet cognitive outcomes that have an impact on morbidity and mortality. Guided by the acceptance of asthma model, an evidence-guided, comprehensive school-based academic health education and counseling program, Staying Healthy-Asthma Responsible & Prepared™ (SHARP), was developed. The program complements existing school curricula by integrating biology, psychology, and sociology content with related spelling, math, and reading and writing assignments. Feasibility, benefits, and efficacy have been established. We compared the effectiveness of SHARP to a non-academic program, Open Airways for Schools, in improving asthma knowledge and reasoning about symptom management. A two-group, cluster-randomized, single-blinded design was used with a sample of 205 students in grades 4-5 with asthma and their caregivers. Schools were matched prior to randomization. The unit of analysis was the student. Certified elementary school teachers delivered the programs during instructional time. Data were collected from student/caregiver dyads at baseline and at 1, 12, and 24 months after the intervention. In multilevel modeling, students enrolled in the academic SHARP program demonstrated significant (padvantages were retained at 24 months. Findings support delivery in schools of the SHARP academic health education program for students with asthma. PMID:26296595

  7. Cost-utility of a disease management program for patients with asthma

    NARCIS (Netherlands)

    Steuten, Lotte; Palmer, Stephen; Vrijhoef, Bert; Merode, van Frits; Spreeuwenberg, Cor; Severens, Hans

    2007-01-01

    Objectives: The long-term cost-utility of a disease management program (DMP) for adults with asthma was assessed compared to usual care. Methods: A DMP for patients with asthma has been developed and implemented in the region of Maastricht (The Netherlands). By integrating care, the program aims to

  8. Identification of gaps in the diagnosis and treatment of childhood asthma using a community-based participatory research approach

    OpenAIRE

    Lewis, Toby C.; Robins, Thomas G.; Joseph, Christine L. M.; Parker, Edith A.; Israel, Barbara A; Rowe, Zachary; Edgren, Katherine K.; Salinas, Maria A.; Martinez, Michael E.; Brown, Randall W

    2004-01-01

    The goal of this investigation was to use a community-based participatory research approach to develop, pilot test, and administer an asthma screening questionnaire to identify children with asthma and asthma symptoms in a community setting. This study was conducted as the recruitment effort for Community Action Against Asthma, a randomized trial of a household intervention to reduce exposure to environmental triggers of asthma and was not designed as a classic prevalence study. An asthma scr...

  9. Creation and implementation of SAMPRO™: A school-based asthma management program.

    Science.gov (United States)

    Lemanske, Robert F; Kakumanu, Sujani; Shanovich, Kathleen; Antos, Nicholas; Cloutier, Michelle M; Mazyck, Donna; Phipatanakul, Wanda; Schantz, Shirley; Szefler, Stanley; Vandlik, Renee; Williams, Paul

    2016-09-01

    Clinicians who care for children with asthma have an obligation to coordinate asthma care with the schools. Aside from routine clinical care of asthmatic children, providers must educate the family and child about the need for an asthma treatment plan in school and support the school nurse meeting the needs of the student requiring school-based asthma care. The following article was developed by multiple stakeholders to address this need. It describes the 4 components of the School-based Asthma Management Program (SAMPRO™). SAMPRO™ details elements necessary for the education of children, families, clinicians, and school-based personnel based on a "circle of support" that would enhance multidirectional communication and promote better care for children with asthma within the school setting. PMID:27596707

  10. Perinatal Programming of Childhood Asthma: Early Fetal Size, Growth Trajectory during Infancy, and Childhood Asthma Outcomes

    Directory of Open Access Journals (Sweden)

    Steve Turner

    2012-01-01

    Full Text Available The “fetal origins hypothesis” or concept of “developmental programming” suggests that faltering fetal growth and subsequent catch-up growth are implicated in the aetiology of cardiovascular disease. Associations between reduced birth weight, rapid postnatal weight gain, and asthma suggest that there are fetal origins to respiratory disease. The present paper first summarises the literature relating birth weight and post natal growth trajectories to asthma outcomes. Second, issues regarding the interpretation of antenatal fetal ultrasound measurements are discussed. Finally, recent reports linking antenatal measurement and growth trajectory to early childhood asthma outcomes are discussed. Understanding the nature and timing of factors which influence antenatal growth may give important insight into the antecedents of early-onset asthma with implications for interventions.

  11. Perinatal Programming of Childhood Asthma: Early Fetal Size, Growth Trajectory during Infancy, and Childhood Asthma Outcomes

    OpenAIRE

    Steve Turner

    2012-01-01

    The “fetal origins hypothesis” or concept of “developmental programming” suggests that faltering fetal growth and subsequent catch-up growth are implicated in the aetiology of cardiovascular disease. Associations between reduced birth weight, rapid postnatal weight gain, and asthma suggest that there are fetal origins to respiratory disease. The present paper first summarises the literature relating birth weight and post natal growth trajectories to asthma outcomes. Second, issues regarding t...

  12. Bronchial asthma and chronic obstructive pulmonary disease: research activity in Arab countries

    OpenAIRE

    Sweileh, Waleed M; Al-Jabi, Samah W.; Zyoud, Sa’ed H; Ansam F Sawalha

    2014-01-01

    Background Chronic respiratory diseases, like bronchial asthma and chronic obstructive pulmonary disease (COPD), are a worldwide health problem. Quantitative and qualitative assessment of asthma and COPD-related research from Arab countries has not been explored and there are few internationally published reports on such field. The main objectives of this study were to analyze research output originating from Arab countries in the field of bronchial asthma and COPD. Methods Original scientifi...

  13. Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial.

    OpenAIRE

    Thomson, NC; Rubin, AS; Niven, RM; Corris, PA; Siersted, HC; Olivenstein, R.; Pavord, ID; McCormack, D.; Laviolette, M.; Shargill, NS; Cox, G.

    2011-01-01

    BACKGROUND: Bronchial thermoplasty (BT) is a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle. Treated patients have been followed out to 5 years to evaluate long-term safety of this procedure. METHODS: Patients enrolled in the Asthma Intervention Research Trial were on inhaled corticosteroids ≥200 μg beclomethasone or equivalent + long-acting-beta2-agonists and demonstrated worsening of asthma on long-acting-β2-agonist withdrawal. Following initial...

  14. Long term (5 Year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial

    OpenAIRE

    Thomson, N C; Rubin, A.S.; Niven, R. M.; Corris, P A; Siersted, H. C.; Olivenstein, R.; Pavord, I.D.; McCormick, D.; Laviolette, M.; Shargill, N.S.; Cox, G.

    2011-01-01

    Background: Bronchial thermoplasty (BT) is a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle. Treated patients have been followed out to 5 years to evaluate long-term safety of this procedure. Methods: Patients enrolled in the Asthma Intervention Research Trial were on inhaled corticosteroids ≥200 μg beclomethasone or equivalent + long-acting-beta2-agonists and demonstrated worsening of asthma on long-acting-β2-agonist withdrawal. ...

  15. Asthma and depression: a pragmatic review of the literature and recommendations for future research

    Directory of Open Access Journals (Sweden)

    Wilson Ian

    2005-09-01

    Full Text Available Abstract Background Although the association between asthma and psychosocial factors has long been recognised, it is only in the last decade that the impact of coexisting asthma and depression has become the focus of considerable research interest. However, the findings so far have been confusing and often contradictory. This paper sets out a methodical review and appraisal of the literature to date, including suggestions for future research. Method PubMed and PsycINFO databases were used to search for English-language articles relating to asthma and depression research. The resulting articles were then reviewed and summarised, creating a report that was used to develop research recommendations. Results The main findings from this review included: (a results are mixed as to whether persons with asthma are more likely to be depressed than those without asthma; (b asthma and depression may have an 'additive' adverse effect on the normal asthma-related quality of life reductions; (c subjective measures of asthma severity may be more strongly related to depression than objective measures; (d specific asthma symptoms appear to be linked to depression; (e sadness and depression can produce respiratory effects consistent with asthma exacerbations; (f depression appears to be negatively related to asthma treatment compliance; (g corticosteroid use in asthma treatment has been associated with depression, though it is unclear how common this problem is in real life; (h interventions that address the physical, psychological, and social consequences of asthma are likely to lead to the most successful treatment outcomes; (i treating the depression of individuals with asthma is likely to minimise the negative effects of the coexistence; and (j a number of common methodological problems were observed in the literature. Recommendations There is a large amount of research yet to be undertaken to clarify issues around asthma and depression, with the overdue next

  16. [Research advances in gene polymorphisms in biological pathways of drugs for asthma].

    Science.gov (United States)

    Guo, Dan-Dan; Zheng, Xiang-Rong

    2016-06-01

    The studies on gene polymorphisms in biological pathways of the drugs for the treatment of asthma refer to the studies in which pharmacogenetic methods, such as genome-wide association studies, candidate gene studies, genome sequencing, admixture mapping analysis, and linkage disequilibrium, are used to identify, determine, and repeatedly validate the effect of one or more single nucleotide polymorphisms on the efficacy of drugs. This can provide therapeutic strategies with optimal benefits, least side effects, and lowest costs to patients with asthma, and thus realize individualized medicine. The common drugs for asthma are β2 receptor agonists, glucocorticoids, and leukotriene modifiers. This article reviews the research achievements in polymorphisms in biological pathways of the common drugs for asthma, hoping to provide guidance for pharmacogenetic studies on asthma in future and realize individualized medicine for patients with asthma soon.

  17. Self-management program in treatment of asthma

    Directory of Open Access Journals (Sweden)

    Milenković Branislava

    2007-01-01

    Full Text Available Introduction. Recently published national and international guidelines stress the importance of self-management in asthma. They have recommended that self-management plans should be an essential part of the long-term management of asthmatic patients. These plans essentially focus on the early recognition of unstable or deteoriorating asthma, by monitoring peak flow or symptoms. Objective. The aim of our one-year study was to compare the efficacy of peak-flow based self-management of asthma with traditional treatment. Method. Sixty clinically stable adult patients with mild and moderate persistent asthma were randomly allocated to peakflow based self-management (Group A, n=30 or to conventional treatment (Group B, n=30, with no significant difference between groups in terms of age, sex distribution and initial lung function. The recorded measurements were: lung function, asthma exacerbations, unscheduled ambulatory care facilities (hospital-based emergency department, consultations with general practitioner or pulmonologist, courses of oral prednisolone, courses of antibiotics, days off work. Results. There was a significant difference between groups in number of asthma exacerbations (p<0.05, unscheduled visits to ambulatory care facilities (p<0.005, days off work (p<0.0001, courses of oral prednisolone (p<0.001 and antibiotics (p<0.05. At the final visit, there was a significant improvement in some measurements of asthma severity in group A (reduced unscheduled visits for ambulatory care, reduced treatment requirements for oral corticosteroids and antibiotics, reduced days off work, but a lack of statistical difference in lung function and the maintenance-inhaled corticosteroid dose. There was no significant change in group B. Conclusion. These results suggest that peak-flow based self management is more effective than traditonal treatment in mild and moderate persistent asthma. .

  18. Associated factors to repeated consultations to the urgencies service for asthma in pediatric patient: Implications for an educational program

    International Nuclear Information System (INIS)

    Bronchial asthma is one of the most frequent respiratory diseases in childhood. Recurrent emergency department visits for asthma produce anxiety and high costs for the system of health and for the family. It is important to know the factors related to these recurrent emergency department visits to assist the targeting of appropriate future interventions aimed at reducing this avoidable presentation. The objective of the present study was to identify factors associated with recurrent emergency department visits for asthma in children liable to be modified by means of an education program. Data obtained from a survey of parents of 146 pediatric patients with asthma attending an asthma clinic and educational program were examined. Parents completed an asthma knowledge and attitudes questionnaire that also included other socio demographic and illness-related variables, including the number of consultations to emergency department by their children asthma in the previous 6 months. Of the 146 asthmatic patients enrolled, 41 (28.1%) consulted repeatedly to the emergency department for asthma. After controlling for age of the patient, educational level of the parents, and functional severity of the disease, we found that parents who reported that they attended to emergency room because asthma attacks of their children were severe enough to go elsewhere (OR, 4.57; CL95%, 1.76- 11.85; P = 0.002), parents who reported that asthma medications should be administered only in symptomatic moments (OR 278, CL 95%, 1.05 - 7.33, P = 0.038 and parents that did not recognize the fact that asthma attacks can be avoided if medications are administered when there are no symptoms (between asthma attacks) (OR 2.61; CL95%; 1.03 - 7.02; p = 0,045), had a greater probability to attend rapidly the emergency room because of asthma of their children. The fact that parents of asthmatic patients have thought that asthma medications should be administered only in symptomatic patients, that they hadn

  19. A workshop on asthma management programs and centers in Brazil: reviewing and explaining concepts

    OpenAIRE

    Rafael Stelmach; Alcindo Cerci Neto; Ana Cristina de Carvalho Fernandez Fonseca; Eduardo Vieira Ponte; Gerardo Alves; Ildely Niedia Araujo-Costa; Laura Maria de Lima Belizário Facury Lasmar; Luci Keiko Kuromoto de Castro; Maria Lucia Medeiros Lenz; Paulo Silva; Alberto Cukier; Alexssandra Maia Alves; Aline Silva Lima-Matos; Amanda da Rocha Oliveira Cardoso; Ana Luisa Godoy Fernandes

    2015-01-01

    Objective: To report the results of a workshop regarding asthma management programs and centers (AMPCs) in Brazil, so that they can be used as a tool for the improvement and advancement of current and future AMPCs. Methods: The workshop consisted of five presentations and the corresponding group discussions. The working groups discussed the following themes: implementation of asthma management strategies; human resources needed for AMPCs; financial resources needed for AMPCs; and operational ...

  20. Towards Excellence in Asthma Management: Final Report of an Eight-Year Program Aimed at Reducing Care Gaps in Asthma Management in Quebec

    OpenAIRE

    Louis-Philippe Boulet; Eileen Dorval; Manon Labrecque; Michel Turgeon; Terrence Montague; Thivierge, Robert L

    2008-01-01

    BACKGROUND AND OBJECTIVES: Asthma care in Canada and around the world persistently falls short of optimal treatment. To optimize care, a systematic approach to identifying such shortfalls or ‘care gaps’, in which all stakeholders of the health care system (including patients) are involved, was proposed.METHODS: Several projects of a multipartner, multidisciplinary disease management program, developed to optimize asthma care in Quebec, was conducted in a period of eight years. First, two popu...

  1. Spirometry in Primary Care: An Analysis of Spirometry Test Quality in a Regional Primary Care Asthma Program

    OpenAIRE

    Licskai, Christopher J; Todd W Sands; Lisa Paolatto; Ivan Nicoletti; Madonna Ferrone

    2012-01-01

    BACKGROUND: Primary care office spirometry can improve access to testing and concordance between clinical practice and asthma guidelines. Compliance with test quality standards is essential to implementation.OBJECTIVE: To evaluate the quality of spirometry performed onsite in a regional primary care asthma program (RAP) by health care professionals with limited training.METHODS: Asthma educators were trained to perform spirometry during two 2 h workshops and supervised during up to six patien...

  2. A workshop on asthma management programs and centers in Brazil: reviewing and explaining concepts

    Directory of Open Access Journals (Sweden)

    Rafael Stelmach

    2015-02-01

    Full Text Available Objective: To report the results of a workshop regarding asthma management programs and centers (AMPCs in Brazil, so that they can be used as a tool for the improvement and advancement of current and future AMPCs. Methods: The workshop consisted of five presentations and the corresponding group discussions. The working groups discussed the following themes: implementation of asthma management strategies; human resources needed for AMPCs; financial resources needed for AMPCs; and operational maintenance of AMPCs. Results: The workshop involved 39 participants, from all regions of the country, representing associations of asthma patients (n = 3, universities (n = 7, and AMPCs (n = 29. We found a direct relationship between a lack of planning and the failure of AMPCs. Based on the experiences reported during the workshop, the common assumptions about AMPCs in Brazil were the importance of raising awareness of managers; greater community participation; interdependence between primary care and specialized care; awareness of regionalization; and use of medications available in the public health system. Conclusions: Brazil already has a core of experience in the area of asthma management programs. The implementation of strategies for the management of chronic respiratory disease and their incorporation into health care system protocols would seem to be a natural progression. However, there is minimal experience in this area. Joint efforts by individuals with expertise in AMPCs could promote the implementation of asthma management strategies, thus speeding the creation of treatment networks, which might have a multiplier effect, precluding the need for isolated centers to start from zero.

  3. A workshop on asthma management programs and centers in Brazil: reviewing and explaining concepts*

    Science.gov (United States)

    Stelmach, Rafael; Neto, Alcindo Cerci; Fonseca, Ana Cristina de Carvalho Fernandez; Ponte, Eduardo Vieira; Alves, Gerardo; Araujo-Costa, Ildely Niedia; Lasmar, Laura Maria de Lima Belizário Facury; de Castro, Luci Keiko Kuromoto; Lenz, Maria Lucia Medeiros; Silva, Paulo; Cukier, Alberto; Alves, Alexssandra Maia; Lima-Matos, Aline Silva; Cardoso, Amanda da Rocha Oliveira; Fernandes, Ana Luisa Godoy; de São-José, Bruno Piassi; Riedi, Carlos Antônio; Schor, Deborah; Peixoto, Décio Medeiros; Brandenburg, Diego Djones; Camillo, Elineide Gomes dos Santos; Serpa, Faradiba Sarquis; Brandão, Heli Vieira; Lima, João Antonio Bonfadini; Pio, Jorge Eduardo; Fiterman, Jussara; Anderson, Maria de Fátima; Cardoso, Maria do Socorro de Lucena; Rodrigues, Marcelo Tadday; Pereira, Marilyn Nilda Esther Urrutia; Antila, Marti; Martins, Sonia Maria; Guimarães, Vanessa Gonzaga Tavares; Mello, Yara Arruda Marques; de Andrade, Wenderson Clay Correia; Salibe-Filho, William; Caldeira, Zelina Maria da Rocha; da Cruz-Filho, Álvaro Augusto Souza; Camargos, Paulo

    2015-01-01

    Objective: To report the results of a workshop regarding asthma management programs and centers (AMPCs) in Brazil, so that they can be used as a tool for the improvement and advancement of current and future AMPCs. Methods: The workshop consisted of five presentations and the corresponding group discussions. The working groups discussed the following themes: implementation of asthma management strategies; human resources needed for AMPCs; financial resources needed for AMPCs; and operational maintenance of AMPCs. Results: The workshop involved 39 participants, from all regions of the country, representing associations of asthma patients (n = 3), universities (n = 7), and AMPCs (n = 29). We found a direct relationship between a lack of planning and the failure of AMPCs. Based on the experiences reported during the workshop, the common assumptions about AMPCs in Brazil were the importance of raising awareness of managers; greater community participation; interdependence between primary care and specialized care; awareness of regionalization; and use of medications available in the public health system. Conclusions: Brazil already has a core of experience in the area of asthma management programs. The implementation of strategies for the management of chronic respiratory disease and their incorporation into health care system protocols would seem to be a natural progression. However, there is minimal experience in this area. Joint efforts by individuals with expertise in AMPCs could promote the implementation of asthma management strategies, thus speeding the creation of treatment networks, which might have a multiplier effect, precluding the need for isolated centers to start from zero. PMID:25750669

  4. Childhood asthma and environmental exposures at swimming pools: state of the science and research recommendations.

    OpenAIRE

    Weisel, C P; Richardson, S.D.; Nemery, B.; Aggazzotti, G.; Baraldi, E.; Blatchley, E.R.; Blount, B.C.; Carlsen, K H; Eggleston, P. A.; Frimmel, F.H.; Goodman, M.; Gordon, G.; Grinshpun, S. A.; Heederik, D.J.J.; Kogevinas, M

    2009-01-01

    OBJECTIVES: Recent studies have explored the potential for swimming pool disinfection by-products (DBPs), which are respiratory irritants, to cause asthma in young children. Here we describe the state of the science on methods for understanding children's exposure to DBPs and biologics at swimming pools and associations with new-onset childhood asthma and recommend a research agenda to improve our understanding of this issue. DATA SOURCES: A workshop was held in Leuven, Belgium, 21-23 August ...

  5. Medication exposure in pregnancy risk evaluation program: the prevalence of asthma medication use during pregnancy.

    Science.gov (United States)

    Hansen, Craig; Joski, Peter; Freiman, Heather; Andrade, Susan; Toh, Sengwee; Dublin, Sascha; Cheetham, Craig; Cooper, William; Pawloski, Pamala; Li, De-Kun; Beaton, Sarah; Kaplan, Sigal; Scott, Pamela; Hammad, Tarek; Davis, Robert

    2013-11-01

    Asthma is one of the most common chronic diseases in women of reproductive age, occurring in up to 8 % of pregnancies. The objective of this study is to assess the prevalence of asthma medication use during pregnancy in a large diverse cohort. We identified women aged 15-45 years who delivered a live born infant between 2001 and 2007 across 11 U.S. health plans within the Medication Exposure in Pregnancy Risk Evaluation Program (MEPREP). Using health plans' administrative and claims data, and birth certificate data, we identified deliveries for which women filled asthma medications from 90 days before pregnancy through delivery. Prevalence (%) was calculated for asthma diagnosis and medication dispensing. There were 586,276 infants from 575,632 eligible deliveries in the MEPREP cohort. Asthma prevalence among mothers was 6.7 %, increasing from 5.5 % in 2001 to 7.8 % in 2007. A total of 9.7 % (n = 55,914) of women were dispensed asthma medications during pregnancy. The overall prevalence of maintenance-only medication, rescue-only medication, and combined maintenance and rescue medication was 0.6, 6.7, and 2.4 % respectively. The prevalence of maintenance-only use doubled during the study period from 0.4 to 0.8 %, while rescue-only use decreased from 7.4 to 5.8 %. In this large population-based pregnancy cohort, the prevalence of asthma diagnoses increased over time. The dispensing of maintenance-only medication increased over time, while rescue-only medication dispensing decreased over time.

  6. Results from a community-based program evaluating the effect of changing smoking status on asthma symptom control

    Directory of Open Access Journals (Sweden)

    To Teresa

    2012-04-01

    Full Text Available Abstract Background Cigarette smoking has been associated with accelerated decline in lung function, increased health services use and asthma severity in patients with asthma. Previous studies have provided insight into how smoking cessation improves lung function among asthma patients, however, fail to provide measurable asthma symptom-specific outcomes after smoking cessation. The objective of this study was to measure the effect of changing smoking status on asthma symptom control and health services use in adults with asthma. Methods The study was conducted in eight primary care practices across Ontario, Canada participating in a community-based, participatory, and evidence-based Asthma Care Program. Patients aged 18 to 55 identified with physician-diagnosed mild to moderate asthma were recruited. In addition to receiving clinical asthma care, participants were administered a questionnaire at baseline and 12-month follow-up visits to collect information on demographics, smoking status, asthma symptoms and routine health services use. The effect of changing smoking status on asthma symptom control was compared between smoking groups using Chi-square and Fisher’s exact tests where appropriate. Mixed effect models were used to measure the impact of the change in smoking status on asthma symptom and health services use while adjusting for covariates. Results This study included 519 patients with asthma; 11% of baseline smokers quit smoking while 4% of baseline non-smokers started smoking by follow-up. Individuals who quit smoking had 80% lower odds of having tightness in the chest (Odds ratio (OR = 0.21, 95% CI: 0.06, 0.82 and 76% lower odds of night-time symptoms (OR = 0.24, 95% CI: 0.07, 0.85 compared to smokers who continued to smoke. Compared to those who remained non-smokers, those who had not been smoking at baseline but self-reported as current smoker at follow-up had significantly higher odds of chest tightness (OR = 1

  7. Epidemiology & Genomics Research Program

    Science.gov (United States)

    The Epidemiology and Genomics Research Program, in the National Cancer Institute's Division of Cancer Control and Population Sciences, funds research in human populations to understand the determinants of cancer occurrence and outcomes.

  8. Childhood Asthma

    Science.gov (United States)

    ... Training Grants & Awards Program Directors Practice Resources ASTHMA IQ Consultation and Referral Guidelines Practice Financial Survey Practice ... one child. Unfortunately, there is not a single test that provides all the answers. An allergist / immunologist, ...

  9. Piping research program plan

    International Nuclear Information System (INIS)

    This document presents the piping research program plan for the Structural and Seismic Engineering Branch and the Materials Engineering Branch of the Division of Engineering, Office of Nuclear Regulatory Research. The plan describes the research to be performed in the areas of piping design criteria, environmentally assisted cracking, pipe fracture, and leak detection and leak rate estimation. The piping research program addresses the regulatory issues regarding piping design and piping integrity facing the NRC today and in the foreseeable future. The plan discusses the regulatory issues and needs for the research, the objectives, key aspects, and schedule for each research project, or group of projects focussing of a specific topic, and, finally, the integration of the research areas into the regulatory process is described. The plan presents a snap-shot of the piping research program as it exists today. However, the program plan will change as the regulatory issues and needs change. Consequently, this document will be revised on a bi-annual basis to reflect the changes in the piping research program. (author)

  10. Building evidence for peer-led interventions: assessing the cost of the Adolescent Asthma Action program in Australia.

    Science.gov (United States)

    Otim, Michael E; Jayasinha, Ranmalie; Forbes, Hayley; Shah, Smita

    2015-01-01

    Asthma is the most common chronic illness among adolescents in Australia. Aboriginal and Torres Strait Islander adolescents, in particular, face substantial inequalities in asthma-related outcomes. Triple A (Adolescent Asthma Action) is a peer-led education intervention, which aims to improve asthma self-management and reduce the uptake of smoking among adolescents. The aim of this study was to determine the cost of implementing the Triple A program in Australia. Standard economic costing methods were used. It involved identifying the resources that were utilised (such as personnel and program materials), measuring them and then valuing them. We later performed sensitivity analysis so as to identify the cost drivers and a stress test to test how the intervention can perform when some inputs are lacking. Results indicate that the estimated cost of implementing the Triple A program in five schools was $41060, assuming that the opportunity cost of all the participants and venues was accounted for. This translated to $8212 per school or $50 per target student. From sensitivity analysis and a stress test, it was identified that the cost of the intervention (in practice) was $14 per student. This appears to be a modest cost, given the burden of asthma. In conclusion, the Triple A program is an affordable intervention to implement in high schools. The potential asthma cost savings due to the program are significant. If the Triple A program is implemented nation-wide, the benefits would be substantial. PMID:25230153

  11. American Academy of Allergy, Asthma, and Immunology

    Science.gov (United States)

    ... Training Grants & Awards Program Directors Practice Resources ASTHMA IQ Consultation and Referral Guidelines Practice Financial Survey Practice ... and other information. Access member only materials Latest Research Inhaler adherence by new electronic technology (INCA) satisfactory ...

  12. Asthma pharmacotherapy.

    Science.gov (United States)

    Schofield, Minka L

    2014-02-01

    Asthma is a chronic inflammatory disease of the airway that leads to airway obstruction via bronchoconstriction, edema, and mucus hypersecretion. The National Asthma Education and Prevention Program has outlined evidence-based guidelines to standardize asthma therapy and improve outcomes. The initial recommendation of choice for persistent asthmatic patients is an inhaled corticosteroid (ICS). Long-acting beta-2 agonists in combination with ICS, oral corticosteroids, leukotriene modifiers, and anti-IgE therapeutic options can be considered for patients with persistent or worsening symptoms. Many novel therapies are being developed, with an emphasis on anti-inflammatory mechanisms, gene expression, and cytokine modification.

  13. Evaluation of Diverse Community Asthma Interventions: Balancing Health Outcomes with Developing Community Capacity for Evidence-Based Program Measurement.

    Science.gov (United States)

    Woodhouse, Lynn D; Livingood, William C; Toal, Russ; Keene, DeAnna; Hines, Robert B; Tedders, Stuart; Charles, Simone M; Lawrence, Raymona H; Gunn, Laura H; Williams, Natalie; Kellum, Andrea

    2015-10-01

    The challenge of evaluating community asthma management programs is complicated by balancing the emphasis on health outcomes with the need to build community process capacity for conducting and monitoring evidence-based programs. The evaluation of a Georgia Childhood Asthma Management Program, a Healthcare Georgia Foundation-supported initiative for multiple diverse programs and settings, provides an example of an approach and the results that address this challenge. A "developmental evaluation" approach was applied, using mixed methods of quantitative and qualitative data collection and analysis, to assess the progress of community asthma prevention programs in building community within the context of: where the community is starting, community-level systems changes, and the community's progress toward becoming more outcome measurement oriented and evidence based. Initial evaluation efforts revealed extensive mobilization of community assets to manage childhood asthma. However, there were minimal planned efforts to assess health outcomes and systems changes, and the lack of a logic model-based program design linking evidence-based practices to outcomes. Following developmental technical assistance within evaluation efforts, all programs developed logic models, linking practices to outcomes with data collection processes to assess progress toward achieving the selected outcomes. This developmental approach across diverse projects and communities, along with a quality improvement benchmarking approach to outcomes, created a focus on health status outcome improvement. Specifically, this approach complemented an emphasis on an improved community process capacity to identify, implement, and monitor evidence-based asthma practices that could be used within each community setting. PMID:25658512

  14. Exercise training in asthma.

    Science.gov (United States)

    Satta, A

    2000-12-01

    Asthma is a chronic disease that is often limiting the exercise capacity. Rehabilitation programs are recommended and widely applied in asthmatic patients, and exercise prescription is a keystone of these programs. The impairment of exercise performance in asthmatics, the role of exercise training in such patients, the mechanisms of its beneficial effects and the suggested programs are discussed in a review, accordingly to the current evidence and available data in scientific literature. Exercise performance is impaired in most asthmatics. There is no conclusive evidence that asthma may involve a ventilatory limitation to exercise. The lesser fitness in asthmatics seems mainly due to inactivity and sedentary lifestyle. Exercise induced asthma (EIA) is a significant problem, and the best approach to minimise its effects on exercise capacity is prevention. Exercise training has been proved to have health-related benefits and to improve the quality of life. There is substantial evidence that exercise training increases exercise performance and fitness in asthmatics. It is still unclear whether physical training improves pulmonary function and bronchial responsiveness. Since asthma ranges widely, exercise prescription varies for each patient. The proper selection of the patients and the choice of exercise programs are the steps required. Accordingly with the severity of the disease, exercise strategies may range from sports activities to, when the disease is severe, inpatient hospital programs that overlap with COPD rehabilitation. Further research to clarify some aspects (effects on pulmonary function and EIA, outcomes, cost-benefit relationship) is necessary. PMID:11296996

  15. Fermilab Research Program Workbook

    International Nuclear Information System (INIS)

    The Fermilab Research Program Workbook has been published annually for the past several years to assist the Physics Advisory Committee in the yearly program review conducted during its summer meeting. While this is still a major aim, it is hoped that the Workbook will also prove useful to others seeking information on the current status of Fermilab experiments and the properties of beams at the Laboratory. In addition, short summaries of approved experiments are also included

  16. A Brief Introduction to Researches on Treatment of Hormone-dependent Asthma with Traditional Chinese Medicine

    Institute of Scientific and Technical Information of China (English)

    崔红生; 武维屏

    2001-01-01

    @@In recent years, with the establishment of the theory of air passage inflammation concerning the pathologic mechanism of asthma, the glucocorticoid hormone (referred to hereafter only as hormone for short), a strong inflammation killer, has become a fundamental medication for treatment of asthma. However, long period of hormone administration will result in general side effects in the whole body as well as hormone dependence, which has now become a hard problem for physicians. Now a non-hormone medication of immunosuppressant has been chosen in western medicine to treat asthma as a replacement or partial replacement of hormone. Nevertheless, its therapeutic effect is not reliable and its side effects severe, hence hardly acceptable to patients. Traditional Chinese medicine (TCM) always adheres to the principle of holistic treatment and has a great advantage in the treatment of this disease. TCM doctors have made some trials and researches in this area and obtained some accomplishments. The following is a brief account of general researches on the treatment of asthma with TCM.

  17. Behavioral consequences of illness: childhood asthma as a model.

    Science.gov (United States)

    Creer, T L; Stein, R E; Rappaport, L; Lewis, C

    1992-11-01

    Several areas of research on childhood asthma are discussed within a transactional model of asthma. The model emphasizes the multidirectional influences that affect the severity of asthma and associated behavioral disability. The initial focus is on how the clinical presentation and morbidity of asthma are affected both by somatic predisposition and by interactions with multiple internal and external elements. Specific elements include emotional factors, neuroimmunology, temperament, and medication side effects. Second, the impact of asthma on the child, his or her family, and segments of the community are described, as are consequences of the disorder on quality of life. Third, there is a synopsis of preventative interventions for reducing the medical and behavioral impact of childhood asthma. The motif is that the interaction of medical and behavioral procedures can improve the management of asthma while consequences of the disorder are mollified. Finally, as examples of a transactional model of asthma, self-management programs for teaching children to become partners with their physicians in establishing and maintaining control over the disorder are described. A representative of self-management--the ACT (Asthma Care Training) program--is described, along with the impact such programs have on children, their families, and institutions. The conclusion emphasizes that asthma is a complicated and unpredictable disorder that puzzles physicians, behavioral scientists, and patients. Although new treatments may be over the horizon, controlling childhood asthma and its consequences currently rests on the cooperation and increased interaction of medical and behavioral scientists. PMID:1437411

  18. EPRI hydrogen research program

    International Nuclear Information System (INIS)

    The need for near-term research on hydrogen behavior as it applies to water reactor safety requires the parallel efforts of a number of organizations. A program has been initiated by EPRI to help answer the most pressing generic questions involving small and large scale combustion, hydrogen mixing, and burn control. Experiments, model development, and code validation work are involved

  19. Controlled thermonuclear research program

    International Nuclear Information System (INIS)

    The Plasma Physics and Controlled-Fusion Research Program at the Lawrence Berkeley Laboratory is divided into five projects: Plasma Production and Heating Experiments, Plasma Theory, Atomic Physics Studies, the Tormac Project, and Neutral-Beam Development and Technology listed in order of increasing magnitude, as regards manpower and budget. Some cross sections and yields are shown in atomic physics

  20. Marine biosurfaces research program

    Science.gov (United States)

    The Office of Naval Research (ONR) of the U.S. Navy is starting a basic research program to address the initial events that control colonization of surfaces by organisms in marine environments. The program “arises from the Navy's need to understand and ultimately control biofouling and biocorrosion in marine environments,” according to a Navy announcement.The program, “Biological Processes Controlling Surface Modification in the Marine Environment,” will emphasize the application of in situ techniques and modern molecular biological, biochemical, and biophysical approaches; it will also encourage the development of interdisciplinary projects. Specific areas of interest include sensing and response to environmental surface (physiology/physical chemistry), factors controlling movement to and retention at surfaces (behavior/hydrodynamics), genetic regulation of attachment (molecular genetics), and mechanisms of attachment (biochemistry/surface chemistry).

  1. Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

    Science.gov (United States)

    Heaney, Liam G; Djukanovic, Ratko; Woodcock, Ashley; Walker, Samantha; Matthews, John G; Pavord, Ian D; Bradding, Peter; Niven, Robert; Brightling, Chris E; Chaudhuri, Rekha; Arron, Joseph R; Choy, David F; Cowan, Douglas; Mansur, Adel; Menzies-Gow, Andrew; Adcock, Ian; Chung, Kian F; Corrigan, Chris; Coyle, Peter; Harrison, Timothy; Johnston, Sebastian; Howarth, Peter; Lordan, James; Sabroe, Ian; Bigler, Jeannette; Smith, Dirk; Catley, Matthew; May, Richard; Pierre, Lisa; Stevenson, Chris; Crater, Glenn; Keane, Frank; Costello, Richard W; Hudson, Val; Supple, David; Hardman, Tim

    2016-02-01

    The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite biomarker strategy to optimise CS dose; this will also address what proportion of patients with severe asthma have persistent symptoms without eosinophilic airways inflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies.

  2. Wood pellet research program

    Energy Technology Data Exchange (ETDEWEB)

    Sohkansanj, S.; Bi, T. [British Columbia Univ., Vancouver, BC (Canada). Dept. of Chemical and Biological Engineering

    2006-07-01

    Wood pellets are composed of waste wood materials such as sawmill residue, municipal landfill waste and grain crops. Due to the high temperature combustion used to form the waste materials into the pellet, no additives or glues are necessary to bind them. The pellets are typically used for home heating; heat and power production; poultry bedding; and in biorefineries. This presentation provided an outline of the University of British Columbia wood pellet research and development program. Research at the university is being conducted to develop new types of pellets. Researchers at the program also analyze the physical and chemical properties of pellets in order to optimize pellet density and heating values. Wood pellet modelling and simulation studies are carried out, and various training and education programs are also offered. Research is currently being conducted to develop a reactor for off-gassing experiments. This presentation also provided details of a study investigating the economics of wood pellet production and transport. Pellet production costs and feedstock costs were compared. A summary of the costs and energy inputs of pellet production included details of product storage; transportation and transfer; handling; and transportation to energy plants. It was concluded that more than 35 per cent of the energy content of biomass is used up in the processing and transport of Canadian wood pellets to Europe. refs., tabs., figs.

  3. Wood pellet research program

    International Nuclear Information System (INIS)

    Wood pellets are composed of waste wood materials such as sawmill residue, municipal landfill waste and grain crops. Due to the high temperature combustion used to form the waste materials into the pellet, no additives or glues are necessary to bind them. The pellets are typically used for home heating; heat and power production; poultry bedding; and in biorefineries. This presentation provided an outline of the University of British Columbia wood pellet research and development program. Research at the university is being conducted to develop new types of pellets. Researchers at the program also analyze the physical and chemical properties of pellets in order to optimize pellet density and heating values. Wood pellet modelling and simulation studies are carried out, and various training and education programs are also offered. Research is currently being conducted to develop a reactor for off-gassing experiments. This presentation also provided details of a study investigating the economics of wood pellet production and transport. Pellet production costs and feedstock costs were compared. A summary of the costs and energy inputs of pellet production included details of product storage; transportation and transfer; handling; and transportation to energy plants. It was concluded that more than 35 per cent of the energy content of biomass is used up in the processing and transport of Canadian wood pellets to Europe. refs., tabs., figs

  4. Nocturnal Asthma

    Science.gov (United States)

    ... Medical Director, Health Initiatives View full profile Nocturnal Asthma Worsening of asthma at night, or nocturnal asthma, ... give extra protection during the night. More Nocturnal Asthma Information Back to Asthma: Types Print Page Email ...

  5. Asthma Basics

    Science.gov (United States)

    ... Tropical Delight: Melon Smoothie Pregnant? Your Baby's Growth Asthma Basics KidsHealth > For Parents > Asthma Basics Print A ... Asthma Categories en español Asma: aspectos fundamentales About Asthma Asthma is a common lung condition in kids ...

  6. Sandia Combustion Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Johnston, S.C.; Palmer, R.E.; Montana, C.A. (eds.)

    1988-01-01

    During the late 1970s, in response to a national energy crisis, Sandia proposed to the US Department of Energy (DOE) a new, ambitious program in combustion research. Shortly thereafter, the Combustion Research Facility (CRF) was established at Sandia's Livermore location. Designated a ''user facility,'' the charter of the CRF was to develop and maintain special-purpose resources to support a nationwide initiative-involving US inventories, industry, and national laboratories--to improve our understanding and control of combustion. This report includes descriptions several research projects which have been simulated by working groups and involve the on-site participation of industry scientists. DOE's Industry Technology Fellowship program, supported through the Office of Energy Research, has been instrumental in the success of some of these joint efforts. The remainder of this report presents results of calendar year 1988, separated thematically into eleven categories. Referred journal articles appearing in print during 1988 and selected other publications are included at the end of Section 11. Our traditional'' research activities--combustion chemistry, reacting flows, diagnostics, engine and coal combustion--have been supplemented by a new effort aimed at understanding combustion-related issues in the management of toxic and hazardous materials.

  7. Fermilab research program workbook

    International Nuclear Information System (INIS)

    The Fermilab Research Program Workbook has been produced annually for the past several years, with the original motivation of assisting the Physics Advisory Committee in its yearly program review conducted during its summer meeting. While this is still the primary goal, the Workbook is increasingly used by others needing information on the current status of Fermilab experiments, properties of beams, and short summaries of approved experiments. At the present time, considerable changes are taking place in the facilities at Fermilab. We have come to the end of the physics program using the 400 GeV Main Ring, which is now relegated to be just an injector for the soon-to-be commissioned Tevatron. In addition, the experimental areas are in the midst of a several-year program of upgrading to 1000 GeV capability. Several new beam lines will be built in the next few years; some indications can be given of their properties, although with the caveat that designs for some are by no means final. Already there is considerable activity leading to experiments studying anti p p collisions at √s = 2000 GeV

  8. National Heart, Lung, and Blood Institute National Asthma Education and Prevention Program

    Science.gov (United States)

    ... pillows, cloth-covered or upholstered furniture, or stuffed toys that harbor dust mites (tiny bugs too small ... more asthma-friendly to promote student health and education. Asthma cannot be cured, but it can be ...

  9. Base Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Everett Sondreal; John Hendrikson

    2009-03-31

    In June 2009, the Energy & Environmental Research Center (EERC) completed 11 years of research under the U.S. Department of Energy (DOE) Base Cooperative Agreement No. DE-FC26-98FT40320 funded through the Office of Fossil Energy (OFE) and administered at the National Energy Technology Laboratory (NETL). A wide range of diverse research activities were performed under annual program plans approved by NETL in seven major task areas: (1) resource characterization and waste management, (2) air quality assessment and control, (3) advanced power systems, (4) advanced fuel forms, (5) value-added coproducts, (6) advanced materials, and (7) strategic studies. This report summarizes results of the 67 research subtasks and an additional 50 strategic studies. Selected highlights in the executive summary illustrate the contribution of the research to the energy industry in areas not adequately addressed by the private sector alone. During the period of performance of the agreement, concerns have mounted over the impact of carbon emissions on climate change, and new programs have been initiated by DOE to ensure that fossil fuel resources along with renewable resources can continue to supply the nation's transportation fuel and electric power. The agreement has addressed DOE goals for reductions in CO{sub 2} emissions through efficiency, capture, and sequestration while expanding the supply and use of domestic energy resources for energy security. It has further contributed to goals for near-zero emissions from highly efficient coal-fired power plants; environmental control capabilities for SO{sub 2}, NO{sub x}, fine respirable particulate (PM{sub 2.5}), and mercury; alternative transportation fuels including liquid synfuels and hydrogen; and synergistic integration of fossil and renewable resources (e.g., wind-, biomass-, and coal-based electrical generation).

  10. Evaluation of a pilot national online asthma e-learning program for secondary school students.

    LENUS (Irish Health Repository)

    Hughes, Mary

    2014-06-01

    Ireland has the fourth highest incidence of asthma in the world, with Irish children losing on average 10 days of school per annum due to their asthma. It is highly probable that a large percentage of students in each class in Irish schools have asthma and are required to manage symptoms during the out-of-home period. Young people with chronic illnesses such as asthma find themselves labelled and marginalized due to a lack of awareness of others about their condition.

  11. Facilitating the Recruitment of Minority Ethnic People into Research: Qualitative Case Study of South Asians and Asthma

    OpenAIRE

    Sheikh, Aziz; Halani, Laila; Bhopal, Raj; Netuveli, Gopalakrishnan; Partridge, Martyn R; Car, Josip; Griffiths, Chris; Levy, Mark

    2009-01-01

    Background: There is international interest in enhancing recruitment of minority ethnic people into research, particularly in disease areas with substantial ethnic inequalities. A recent systematic review and meta-analysis found that UK South Asians are at three times increased risk of hospitalisation for asthma when compared to white Europeans. US asthma trials are far more likely to report enrolling minority ethnic people into studies than those conducted in Europe. We investigated approach...

  12. Jointly Sponsored Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Everett A. Sondreal; John G. Hendrikson; Thomas A. Erickson

    2009-03-31

    U.S. Department of Energy (DOE) Cooperative Agreement DE-FC26-98FT40321 funded through the Office of Fossil Energy and administered at the National Energy Technology Laboratory (NETL) supported the performance of a Jointly Sponsored Research Program (JSRP) at the Energy & Environmental Research Center (EERC) with a minimum 50% nonfederal cost share to assist industry in commercializing and effectively applying highly efficient, nonpolluting energy systems that meet the nation's requirements for clean fuels, chemicals, and electricity in the 21st century. The EERC in partnership with its nonfederal partners jointly performed 131 JSRP projects for which the total DOE cost share was $22,716,634 (38%) and the nonfederal share was $36,776,573 (62%). Summaries of these projects are presented in this report for six program areas: (1) resource characterization and waste management, (2) air quality assessment and control, (3) advanced power systems, (4) advanced fuel forms, (5) value-added coproducts, and (6) advanced materials. The work performed under this agreement addressed DOE goals for reductions in CO{sub 2} emissions through efficiency, capture, and sequestration; near-zero emissions from highly efficient coal-fired power plants; environmental control capabilities for SO{sub 2}, NO{sub x}, fine respirable particulate (PM{sub 2.5}), and mercury; alternative transportation fuels including liquid synfuels and hydrogen; and synergistic integration of fossil and renewable resources.

  13. Sustaining School-Based Asthma Interventions through Policy and Practice Change

    Science.gov (United States)

    Carpenter, Laurie M.; Lachance, Laurie; Wilkin, Margaret; Clark, Noreen M.

    2013-01-01

    Background: Schools are an ideal setting for implementation of asthma interventions for children; however, sustaining school-based programs can be challenging. This study illustrates policy and practice changes brought about through the Childhood Asthma Linkages in Missouri (CALM) program to sustain such programs. Methods: Researchers analyzed…

  14. Paediatric asthma and obesity.

    Science.gov (United States)

    Lucas, Sean R; Platts-Mills, Thomas A E

    2006-12-01

    None of the explanations proposed for the increase in paediatric asthma have been adequate. It is becoming apparent that the cause of the increase in asthma must be multi-factorial. Increasing attention has been focused on the role of lifestyle in the development of asthma. Lifestyle changes that have occurred in children are those in diet and decreased physical activity, with obesity being the product of these changes. The increase in asthma, obesity and a sedentary lifestyle have occurred together. However, a temporal relationship between asthma, obesity and decreased physical activity has not been determined in the paediatric literature. Limited data suggest that decreased physical activity could be playing a role in the aetiology of asthma independent of obesity. Furthermore, there has been substantial research on the benefits of exercise programmes for paediatric patients with asthma. Longitudinal trials monitoring physical activity, obesity and the development of asthma are needed. PMID:17098637

  15. Children with Asthma and Sports

    OpenAIRE

    Selda Yuzer; Sevinc Polat

    2014-01-01

    Asthma is one of the chronic diseases which have are widely seen among the children. The disease has recently been in the increase all over the world and affects many children. In a study conducted with International Study of Asthma and Allergies in Childhood (ISAAC) method, it was found out that prevalence of childhood asthma was 17.1%. Participation in sportive activities by the children with asthma, which is today considered as a part of asthma treatment program, makes contributions to the...

  16. Component fragility research program

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, N.C.; Mochizuki, G.L.; Holman, G.S. (NCT Engineering, Inc., Lafayette, CA (USA); Lawrence Livermore National Lab., CA (USA))

    1989-11-01

    To demonstrate how high-level'' qualification test data can be used to estimate the ultimate seismic capacity of nuclear power plant equipment, we assessed in detail various electrical components tested by the Pacific Gas Electric Company for its Diablo Canyon plant. As part of our Phase I Component Fragility Research Program, we evaluated seismic fragility for five Diablo Canyon components: medium-voltage (4kV) switchgear; safeguard relay board; emergency light battery pack; potential transformer; and station battery and racks. This report discusses our Phase II fragility evaluation of a single Westinghouse Type W motor control center column, a fan cooler motor controller, and three local starters at the Diablo Canyon nuclear power plant. These components were seismically qualified by means of biaxial random motion tests on a shaker table, and the test response spectra formed the basis for the estimate of the seismic capacity of the components. The seismic capacity of each component is referenced to the zero period acceleration (ZPA) and, in our Phase II study only, to the average spectral acceleration (ASA) of the motion at its base. For the motor control center, the seismic capacity was compared to the capacity of a Westinghouse Five-Star MCC subjected to actual fragility tests by LLNL during the Phase I Component Fragility Research Program, and to generic capacities developed by the Brookhaven National Laboratory for motor control center. Except for the medium-voltage switchgear, all of the components considered in both our Phase I and Phase II evaluations were qualified in their standard commercial configurations or with only relatively minor modifications such as top bracing of cabinets. 8 refs., 67 figs., 7 tabs.

  17. Difficult asthma.

    OpenAIRE

    Ahmet Uslu; Tülay Özdemir

    1989-01-01

    Difficult asthma is a distinct entity of asthma, comprising approximately %5 of asthmatic patients. There is no agreed definition of difficult asthma. It will include asthma uncontrolled by new standard therapy, steroid dependent, steroid resistant and severe asthma. In this study difficult asthma; clinical features, risk factors, pathophysiology and novel therapies are summarized by literatures.

  18. The application of theory in childhood asthma self-help programs.

    Science.gov (United States)

    Bruhn, J G

    1983-11-01

    Theories from research in health education and compliance (adherence) behavior are reviewed and examined for their applicability to studies of self-management of childhood asthma. Specific theories discussed include: (1) the health belief model, (2) models of health, illness, and sick-role behavior, (3) social learning theory, (4) models of physician-patient relationships, (5) self-regulation model, (6) communication theory, (7) attribution, control, and decision-making theory, (8) grounded theory, (9) ecologic theory, and (10) family and social systems theories. A scheme to guide development and testing of theories in children's health and illness behavior is presented. The key common elements in the examined theories on adherence behavior are integrated and organized into a paradigm for the family determinants of the self-management of chronic illness.

  19. Equipment qualification research program: program plan

    International Nuclear Information System (INIS)

    The Lawrence Livermore National Laboratory (LLNL) under the sponsorship of the US Nuclear Regulatory Commission (NRC) has developed this program plan for research in equipment qualification (EQA). In this report the research program which will be executed in accordance with this plan will be referred to as the Equipment Qualification Research Program (EQRP). Covered are electrical and mechanical equipment under the conditions described in the OBJECTIVE section of this report. The EQRP has two phases; Phase I is primarily to produce early results and to develop information for Phase II. Phase I will last 18 months and consists of six projects. The first project is program management. The second project is responsible for in-depth evaluation and review of EQ issues and EQ processes. The third project is responsible for detailed planning to initiate Phase II. The remaining three projects address specific equipment; i.e., valves, electrical equipment, and a pump

  20. "Kickin' Asthma": School-Based Asthma Education in an Urban Community

    Science.gov (United States)

    Magzamen, Sheryl; Patel, Bina; Davis, Adam; Edelstein, Joan; Tager, Ira B.

    2008-01-01

    Background: In urban communities with high prevalence of childhood asthma, school-based educational programs may be the most appropriate approach to deliver interventions to improve asthma morbidity and asthma-related outcomes. The purpose of this study was to evaluate the implementation of "Kickin' Asthma", a school-based asthma curriculum…

  1. Promoting Self-Management in Adults with Asthma: An Overview of the UAB Program.

    Science.gov (United States)

    Bailey, William C.; And Others

    1987-01-01

    A study at the University of Alabama/Birmingham (UAB) compared adult asthma patients receiving a self-care workbook with those receiving only asthma pamphlets. Outcomes were assessed in five areas: (1) health care utilization, (2) functional status, (3) knowledge, (4) adherence, and (5) psychological reactions. (Author/CH)

  2. The primary prevention of asthma in children study: design of a multifaceted prevention program.

    NARCIS (Netherlands)

    Kuiper, S.; Maas, T.; Schayck, C.P. van; Muris, J.W.M.; Schonberger, H.J.; Dompeling, E.C.; Gijsbers, B.; Weel, C. van; Knottnerus, J.A.

    2005-01-01

    The PREVASC study addresses the primary prevention of asthma in infants and small children. The objective of this study is to investigate whether a multifaceted prenatally started intervention strategy in high-risk infants leads to a decrease in the occurrence of (severe) asthma and whether a refine

  3. Preliminary Testing of an Asthma Distance Education Program (ADEP) for School Nurses in Appalachia

    Science.gov (United States)

    Putman-Casdorph, Heidi; Pinto, Susan

    2011-01-01

    Asthma remains one of the most challenging chronic illnesses faced by school nurses both nationally and in the State of West Virginia. There is a clear need to provide ongoing continuing asthma education to school nurses. However, nurses face many barriers to receiving this education. The purpose of this pilot project was to develop and evaluate…

  4. NCI: DCTD: Biometric Research Program

    Science.gov (United States)

    The Biometric Research Program (BRP) is the statistical and biomathematical component of the Division of Cancer Treatment, Diagnosis and Centers (DCTDC). Its members provide statistical leadership for the national and international research programs of the division in developmental therapeutics, developmental diagnostics, diagnostic imaging and clinical trials.

  5. [Survey of clinical and experimental researches on mechanisms of acupuncture treatment of bronchial asthma].

    Science.gov (United States)

    Tan, Cheng; Zhao, Ji-ping; Zhang, Chang

    2011-08-01

    In the present paper, the authors review the development of experimental and clinical studies on acupuncture treatment of bronchial asthma in recent 10 years. Regarding clinical studies, results showed that acupuncture could (1) regulate cardiac-pulmonary function; and (2) adjust immune state and relieve inflammatory reactions in bronchial asthma patients. Animal experiments showed that acupuncture could function in (1) improving pulmonary function; (2) reducing accumulation of the peripheral eosinophile granulocytes (EOS), relieving the infiltration of inflammatory cells in the air-passage mucosa and promoting the apoptosis of EOS in the lung and air-passages; (3) down-regulating the expression of air-passage remodeling-related protein insulin growth factor-1; (4) suppressing the secretion of tumor necrosis factor and endothelin; (5) attenuating allergic reaction; (6) regulating neuroendocrine activity; and (7) modulating intracellular second messenger activities. However, rigorous clinical study design is not enough, so that the reliability of the results is limited. In spite of many indicators of animal experiments have been selected, but their correlations are not in close association, resulting in poor complementation and mutual identification of the acquired findings. For this reason, its clinical efficacies need to be researched further according to principles of evidence-based medicine. PMID:21942186

  6. Radon Research Program, FY-1990

    International Nuclear Information System (INIS)

    The Department of Energy (DOE) Office of Health and Environmental Research (OHER) has established a Radon Research Program with the primary objectives of acquiring knowledge necessary to improve estimates of health risks associated with radon exposure and also to improve radon control. Through the Radon Research Program, OHER supports and coordinates the research activities of investigators at facilities all across the nation. From this research, significant advances are being made in our understanding of the health effects of radon. OHER publishes this annual report to provide information to interested researchers and the public about its research activities. This edition of the report summarizes the activities of program researchers during FY90. Chapter 2 of this report describes how risks associated with radon exposure are estimated, what assumptions are made in estimating radon risks for the general public, and how the uncertainties in these assumptions affect the risk estimates. Chapter 3 examines how OHER, through the Radon Research Program, is working to gather information for reducing the uncertainties and improving the risk estimates. Chapter 4 highlights some of the major findings of investigators participating in the Radon Research Program in the past year. And, finally, Chapter 5 discusses the direction in which the program is headed in the future. 20 figs

  7. Ecological Research Division, Marine Research Program

    Energy Technology Data Exchange (ETDEWEB)

    1980-05-01

    This report presents program summaries of the various projects sponsored during 1979 by the Marine Research Program of the Ecological Research Division. Program areas include the effects of petroleum hydrocarbons on the marine environment; a study of the baseline ecology of a proposed OTEC site near Puerto Rico; the environmental impact of offshore geothermal energy development; the movement of radionuclides through the marine environment; the environmental aspects of power plant cooling systems; and studies of the physical and biological oceangraphy of the continental shelves bordering the United States.

  8. Ecological Research Division, Marine Research Program

    International Nuclear Information System (INIS)

    This report presents program summaries of the various projects sponsored during 1979 by the Marine Research Program of the Ecological Research Division. Program areas include the effects of petroleum hydrocarbons on the marine environment; a study of the baseline ecology of a proposed OTEC site near Puerto Rico; the environmental impact of offshore geothermal energy development; the movement of radionuclides through the marine environment; the environmental aspects of power plant cooling systems; and studies of the physical and biological oceangraphy of the continental shelves bordering the United States

  9. Asthma and air pollution in the Bronx: methodological and data considerations in using GIS for environmental justice and health research.

    Science.gov (United States)

    Maantay, Juliana

    2007-03-01

    This paper examines methods of environmental justice assessment with Geographic Information Systems, using research on the spatial correspondence between asthma and air pollution in the Bronx, New York City as a case study. Issues of spatial extent and resolution, the selection of environmental burdens to analyze, data and methodological limitations, and different approaches to delineating exposure are discussed in the context of the asthma study, which, through proximity analysis, found that people living near (within specified distance buffers) noxious land uses were up to 66 percent more likely to be hospitalized for asthma, and were 30 percent more likely to be poor and 13 percent more likely to be a minority than those outside the buffers.

  10. Human Research Program

    Data.gov (United States)

    National Aeronautics and Space Administration — Strategically, the HRP conducts research and technology development that: 1) enables the development or modification of Agency-level human health and performance...

  11. American Overseas Research Centers Program

    Science.gov (United States)

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The American Overseas Research Centers Program provides grants to overseas research centers that are consortia of U.S. institutions of higher education to enable the centers to promote postgraduate research, exchanges, and area studies. Eligible applicants are those consortia of U.S. institutions of higher education centers that: (1) Receive more…

  12. Psychological aspects of asthma.

    Science.gov (United States)

    Lehrer, Paul; Feldman, Jonathan; Giardino, Nicholas; Song, Hye-Sue; Schmaling, Karen

    2002-06-01

    Asthma can be affected by stress, anxiety, sadness, and suggestion, as well as by environmental irritants or allergens, exercise, and infection. It also is associated with an elevated prevalence of anxiety and depressive disorders. Asthma and these psychological states and traits may mutually potentiate each other through direct psychophysiological mediation, nonadherence to medical regimen, exposure to asthma triggers, and inaccuracy of asthma symptom perception. Defensiveness is associated with inaccurate perception of airway resistance and stress-related bronchoconstriction. Asthma education programs that teach about the nature of the disease, medications, and trigger avoidance tend to reduce asthma morbidity. Other promising psychological interventions as adjuncts to medical treatment include training in symptom perception, stress management, hypnosis, yoga, and several biofeedback procedures. PMID:12090377

  13. Tansmutation Research program

    Energy Technology Data Exchange (ETDEWEB)

    Seidler, Paul

    2011-07-31

    Six years of research was conducted for the United States Department of Energy, Office of Nuclear Energy between the years of 2006 through 2011 at the University of Nevada, Las Vegas (UNLV). The results of this research are detailed in the narratives for tasks 1-45. The work performed spanned the range of experimental and modeling efforts. Radiochemistry (separations, waste separation, nuclear fuel, remote sensing, and waste forms) , material fabrication, material characterization, corrosion studies, nuclear criticality, sensors, and modeling comprise the major topics of study during these six years.

  14. Mouse Models Applied to the Research of Pharmacological Treatments in Asthma.

    Science.gov (United States)

    Marqués-García, Fernando; Marcos-Vadillo, Elena

    2016-01-01

    Models developed for the study of asthma mechanisms can be used to investigate new compounds with pharmacological activity against this disease. The increasing number of compounds requires a preclinical evaluation before starting the application in humans. Preclinical evaluation in animal models reduces the number of clinical trials positively impacting in the cost and in safety. In this chapter, three protocols for the study of drugs are shown: a model to investigate corticoids as a classical treatment of asthma; a protocol to test the effects of retinoic acid (RA) on asthma; and a mouse model to test new therapies in asthma as monoclonal antibodies. PMID:27300543

  15. Radon Research Program, FY 1991

    International Nuclear Information System (INIS)

    The scientific information being sought in this program encompasses research designed to determine radon availability and transport outdoors, modeling transport into and within buildings, physics and chemistry of radon and radon progeny, dose response relationships, lung cancer risk, and mechanisms of radon carcinogenesis. The main goal of the DOE/OHER Radon Research Program is to develop information to reduce these uncertainties and thereby provide an improved health risk estimate of exposure to radon and its progeny as well as to provide information useful in radon control strategies. Results generated under the Program were highlighted in a National Research Council report on radon dosimetry. The study concluded that the risk of radon exposure is 30% less in homes than in mines. This program summary of book describes the OHER FY-1991 Radon Research Program. It is the fifth in an annual series of program books designed to provide scientific and research information to the public and to other government agencies on the DOE Radon Research Program

  16. Fermilab research Program 1976

    Energy Technology Data Exchange (ETDEWEB)

    Lach, J., (Ed.); /Fermilab

    1976-01-01

    This collection of one-page summaries of Fermilab proposals is intended to serve as a way station between the experiment number with its short title and the full proposal. It is not intended to be a review of the Fermilab experimental program. Just as an abstract of a journal article embodies the main points of the article, so these one-page summaries are intended to convey the major points of a proposal. These should include its physics justification, a brief description of the apparatus and the demands that the experiment will make on the Laboratory. Of course these summaries are not intended to take the place of the proposal itself which is the primary document available in the Fermilab library and at SLAC, BNL and CERN. Individual copies should be obtained from the spokesman of the experiment whose name is underlined in these summaries. Summaries for all experiments and pending proposals are included. These comprise approved, unconsidered and deferred proposals. Rejected, withdrawn and inactive proposals are not included. It is the experimenters themselves who are best able to write the summary and in most cases that is what was done. For the early proposals and those cases where repeated cajoling could not produce one from the experimenters, the summary was prepared by a Fermilab staff member and then sent to the spokesman for comment. All proposals submitted before the May 7, 1976 deadline for consideration at the extended summer meeting of our Program Advisory Committee are included. It is not intended that this volume be updated annually but perhaps only reissued when the previous ones becomes hopelessly obsolete.

  17. Geothermal subsidence research program plan

    Energy Technology Data Exchange (ETDEWEB)

    1977-04-01

    A comprehensive research program to investigate subsidence from geothermal energy production was developed from the point of view of a developer of an energy facility and the policy maker who regulates such facilities. The organizational structure, objectives, and time schedule are outlined. Each of the research categories is discussed separately. (MHR)

  18. NASA's computer science research program

    Science.gov (United States)

    Larsen, R. L.

    1983-01-01

    Following a major assessment of NASA's computing technology needs, a new program of computer science research has been initiated by the Agency. The program includes work in concurrent processing, management of large scale scientific databases, software engineering, reliable computing, and artificial intelligence. The program is driven by applications requirements in computational fluid dynamics, image processing, sensor data management, real-time mission control and autonomous systems. It consists of university research, in-house NASA research, and NASA's Research Institute for Advanced Computer Science (RIACS) and Institute for Computer Applications in Science and Engineering (ICASE). The overall goal is to provide the technical foundation within NASA to exploit advancing computing technology in aerospace applications.

  19. Research program plan: steam generators

    International Nuclear Information System (INIS)

    This document presents a plan for research in Steam Generators to be performed by the Materials Engineering Branch, MEBR, Division of Engineering Technology, (EDET), Office of Nuclear Regulatory Research. It is one of four plans describing the ongoing research in the corresponding areas of MEBR activity. In order to answer the questions posed, the Steam Generator Program has been organized with the three elements of non-destructive examination; mechanical integrity testing; and corrosion, cleaning and decontamination

  20. Research Grants Program Office Open Access Policy

    OpenAIRE

    Research Grant Program Office (RGPO)

    2014-01-01

    This is the Open Access Policy for all research funded through the Research Grants Program Office in the University of California Office of the President. Specifically, it applies to all research funded through UC Research Initiatives (UCRI), the California Breast Cancer Prevention Program (CBCRP), the Tobacco-Related Disease Research Program (TRDRP), and the California HIV/AIDS Research Program (CHRP).  

  1. Jointly Sponsored Research Program Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    Western Research Institute

    2009-03-31

    Cooperative Agreement, DE-FC26-98FT40323, Jointly Sponsored Research (JSR) Program at Western Research Institute (WRI) began in 1998. Over the course of the Program, a total of seventy-seven tasks were proposed utilizing a total of $23,202,579 in USDOE funds. Against this funding, cosponsors committed $26,557,649 in private funds to produce a program valued at $49,760,228. The goal of the Jointly Sponsored Research Program was to develop or assist in the development of innovative technology solutions that will: (1) Increase the production of United States energy resources - coal, natural gas, oil, and renewable energy resources; (2) Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; (3) Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and (4) Minimize environmental impacts of energy production and utilization. Under the JSR Program, energy-related tasks emphasized enhanced oil recovery, heavy oil upgrading and characterization, coal beneficiation and upgrading, coal combustion systems development including oxy-combustion, emissions monitoring and abatement, coal gasification technologies including gas clean-up and conditioning, hydrogen and liquid fuels production, coal-bed methane recovery, and the development of technologies for the utilization of renewable energy resources. Environmental-related activities emphasized cleaning contaminated soils and waters, processing of oily wastes, mitigating acid mine drainage, and demonstrating uses for solid waste from clean coal technologies, and other advanced coal-based systems. Technology enhancement activities included resource characterization studies, development of improved methods, monitors and sensors. In general the goals of the tasks proposed were to enhance competitiveness of U.S. technology, increase production of domestic resources, and reduce environmental

  2. Role of Obesity in Asthma Control, the Obesity-Asthma Phenotype

    OpenAIRE

    Shannon Novosad; Supriya Khan; Bruce Wolfe; Akram Khan

    2013-01-01

    Asthma is a disease with distinct phenotypes that have implications for both prognosis and therapy. Epidemiologic studies have demonstrated an association between asthma and obesity. Further studies have shown that obese asthmatics have poor asthma control and more severe asthma. This obese-asthma group may represent a unique phenotype. The mechanisms behind poor asthma control in obese subjects remain unclear, but recent research has focused on adipokines and their effects on the airways as ...

  3. Containment integrity research program plan

    International Nuclear Information System (INIS)

    This report presents a plan for research on the question of containment performance in postulated severe accident scenarios. It focuses on the research being performed by the Structural and Seismic Engineering Branch, Division of Engineering, Office of Nuclear Regulatory Research. Summaries of the plans for this work have previously been published in the ''Nuclear Power Plant Severe Accident Research Plan'' (NUREG-0900). This report provides an update to reflect current status. This plan provides a summary of results to date as well as an outline of planned activities and milestones to the contemplated completion of the program in FY 1989

  4. Exercise and Asthma

    Science.gov (United States)

    ... Training Grants & Awards Program Directors Practice Resources ASTHMA IQ Consultation and Referral Guidelines Practice Financial Survey Practice ... conducting a physical examination and performing a breathing test called spirometry. If your breathing test shows that ...

  5. In Vivo Computed Tomography as a Research Tool to Investigate Asthma and COPD: Where Do We Stand?

    Directory of Open Access Journals (Sweden)

    Gaël Dournes

    2012-01-01

    Full Text Available Computed tomography (CT is a clinical tool widely used to assess and followup asthma and chonic obstructive pulmonary disease (COPD in humans. Strong efforts have been made the last decade to improve this technique as a quantitative research tool. Using semiautomatic softwares, quantification of airway wall thickness, lumen area, and bronchial wall density are available from large to intermediate conductive airways. Skeletonization of the bronchial tree can be built to assess its three-dimensional geometry. Lung parenchyma density can be analysed as a surrogate of small airway disease and emphysema. Since resident cells involve airway wall and lung parenchyma abnormalities, CT provides an accurate and reliable research tool to assess their role in vivo. This litterature review highlights the most recent advances made to assess asthma and COPD with CT, and also their drawbacks and the place of CT in clarifying the complex physiopathology of both diseases.

  6. GA2LEN (Global Allergy and Asthma European Network) addresses the allergy and asthma 'epidemic'

    DEFF Research Database (Denmark)

    Bousquet, J; Burney, P G; Zuberbier, T;

    2009-01-01

    and the first papers are being published. Achievements of the Global Allergy and Asthma European Network can be grouped as follows: (i) those for a durable infrastructure built up during the project phase, (ii) those which are project-related and based on these novel infrastructures, and (iii) the development......Allergic diseases represent a major health problem in Europe. They are increasing in prevalence, severity and costs. The Global Allergy and Asthma European Network (GA(2)LEN), a Sixth EU Framework Program for Research and Technological Development (FP6) Network of Excellence, was created in 2005...... as a vehicle to ensure excellence in research bringing together research and clinical institutions to combat fragmentation in the European research area and to tackle allergy in its globality. The Global Allergy and Asthma European Network has benefited greatly from the voluntary efforts of researchers who...

  7. Research on pharmacological mechanism of the treatment of Asthma by oral Bordetella pertussis

    Institute of Scientific and Technical Information of China (English)

    CHI Shen; SUN Yun; ZHANG Bao-yuan

    2008-01-01

    Objective To examine the effect of oral Bordetella pertussis on the asthma mice sensitized by ovalbumin (OVA), and explore the possible mechanism. Methods Culture the B. pertussis in Bordet-Gengou agar containing 25 % rabbit blood. Collect the bacteria and inactive them at 80 ℃ for 30 min to get whole killed B. pertussis. 32 BALB/C mice were randomly divided into control group, model-control group, model group and treatment group. The mice were sensitized and challenged with OVA to establish asthma model. Asthma mice in treatment group were orally administrated with B. pertussis 7 days before sensitization. The mice in control group and model-control group were challenged with saline. After 24 hours of last challenge, bronchoaveolar lavage fluid (BALF) and peripheral blood were collected. The total cells and eosinophils were counted in BALF. Results Compared with the control group (2.03±0.42, 0.33±0.82)× 105 mL-1 and model-control group (2.16±0.48,0.16±0.41)×105 mL-1, the total cells (10.13±1.33) ×105mL-1 and eosinophils (11.83±4.573)×105 mL-1 in BALF were more in asthma mice (P<0.01). The number of total cells (5.50±1.55)×105 mL-1 and eosinophils(0.66±0.82)×105 mL-1 in BALF were reduced in asthma mice treated with B. pertussis compared with asthma mice(P<0.01 ). Conclusions Oral B. pertussis can inhabit airway inflammation of asthma mice and has the potential of treating asthma.

  8. Army ground robotics research program

    Science.gov (United States)

    Bornstein, Jonathan A.

    2002-07-01

    The U.S. Army has committed to a paradigm shift in the way future ground military operations will be conducted. It envisions highly mobile, lethal, and survivable forces that seamlessly combine manned and unmanned elements. To support this vision, the U.S. Army Research Laboratory, together with an alliance of government, industrial and academic organizations, has embarked upon a concerted research program focusing upon development of the technologies required for autonomous ground mobility by unmanned systems. This paper will discuss technical activities of the past year and research directions for the future.

  9. Subsurface transport program: Research summary

    International Nuclear Information System (INIS)

    DOE's research program in subsurface transport is designed to provide a base of fundamental scientific information so that the geochemical, hydrological, and biological mechanisms that contribute to the transport and long term fate of energy related contaminants in subsurface ecosystems can be understood. Understanding the physical and chemical mechanisms that control the transport of single and co-contaminants is the underlying concern of the program. Particular attention is given to interdisciplinary research and to geosphere-biosphere interactions. The scientific results of the program will contribute to resolving Departmental questions related to the disposal of energy-producing and defense wastes. The background papers prepared in support of this document contain additional information on the relevance of the research in the long term to energy-producing technologies. Detailed scientific plans and other research documents are available for high priority research areas, for example, in subsurface transport of organic chemicals and mixtures and in the microbiology of deep aquifers. 5 figs., 1 tab

  10. Global undersea research program examined

    Science.gov (United States)

    Hotta, /. H.; Hattori, M.; Fujioka, K.; Kusakabe, M.; Matsumoto, T.; Tanaka, T.

    Geological understanding of age and horizontal variations of oceanic plates from mid-ocean ridges to deep-sea trenches, including interactive phenomena between continental and oceanic plates, especially in areas transecting trenches, arcs, and back-arc basins was addressed at the 1992 Workshop on the Global Undersea Research Program, held at the Japan Marine Science and Technology Center (JAMSTEC), Tokyo, Japan, from September 2 to 4, 1992. The meeting was held following a proposal at the 1991 International Symposium to commemorate the 20th anniversary of JAMSTEC to hold a workshop on undersea research to discuss the utilization of undersea devices such as manned submersibles and remotely operated vehicles (ROVs).The goals of the September meeting were to improve research cooperation among organizations using manned submersibles or ROVs; to support more effective research programs by avoiding unnecessary research duplication; and to discuss new technologies, scientific needs, and functional requirements for hardware being developed for manned submersibles and ROVs. About twenty-five scientists participated from the National Science Foundation; National Oceanic and Atmospheric Administration; Woods Hole Oceanographic Institution (WHOI); University of Hawaii; Institut Français de Recherche pour l'Exploitation des Mers (IFREMER), France; Ocean Research Institute, University of Tokyo; Earthquake Research Institute, University of Tokyo; Geological Survey of Japan; Institute of Oceanographic Sciences (IOS), Deacon Laboratory, United Kingdom; and JAMSTEC.

  11. Guidelines for asthma management: a review and comparison of 5 current guidelines.

    Science.gov (United States)

    Myers, Timothy R

    2008-06-01

    The first clinical practice guidelines for the assessment and management of asthma were published over 20 years ago in New Zealand and Australia. During the same period, British and Scottish groups were collaborating on a United Kingdom version of asthma guidelines. Shortly after the introduction of the New Zealand and Canadian guidelines, the National Heart, Lung, and Blood Institute of the United States National Institutes of Health participated in 2 additional asthma guideline endeavors, which were published in the early 1990s. The National Heart, Lung, and Blood Institute formed the National Asthma Education and Prevention Program to develop asthma guidelines for the United States, and participated with an international task force to develop guidelines for the treatment of asthma in all countries, which resulted in the formation of the Global Initiative for Asthma in the mid-1990s. The asthma guidelines issued by professional societies and other groups prior to the late 1990s were primarily based on consensus or expert opinion in each guideline committee, though those opinions were based on the available studies. The early guidelines played a vital role in bridging the gap between various treatment options and recent discoveries in basic science, and served as the vehicle to implementation into daily clinical practice. Asthma guidelines have been published and revised in dozens of countries around the world and have become reputable directives or "road maps" in asthma diagnosis, treatment, and management for patients of all ages. The guidelines have similar formats. The dissemination and implementation of the early guidelines was inconsistent, and they were criticized for not being evidence-based. As the knowledge of asthma pathophysiology continues to expand, along with basic science research on asthma diagnosis, treatment, and management, as well as education of the asthma patient, it is essential that the asthma guidelines be frequently updated and based on

  12. Clean Coal Program Research Activities

    Energy Technology Data Exchange (ETDEWEB)

    Larry Baxter; Eric Eddings; Thomas Fletcher; Kerry Kelly; JoAnn Lighty; Ronald Pugmire; Adel Sarofim; Geoffrey Silcox; Phillip Smith; Jeremy Thornock; Jost Wendt; Kevin Whitty

    2009-03-31

    Although remarkable progress has been made in developing technologies for the clean and efficient utilization of coal, the biggest challenge in the utilization of coal is still the protection of the environment. Specifically, electric utilities face increasingly stringent restriction on the emissions of NO{sub x} and SO{sub x}, new mercury emission standards, and mounting pressure for the mitigation of CO{sub 2} emissions, an environmental challenge that is greater than any they have previously faced. The Utah Clean Coal Program addressed issues related to innovations for existing power plants including retrofit technologies for carbon capture and sequestration (CCS) or green field plants with CCS. The Program focused on the following areas: simulation, mercury control, oxycoal combustion, gasification, sequestration, chemical looping combustion, materials investigations and student research experiences. The goal of this program was to begin to integrate the experimental and simulation activities and to partner with NETL researchers to integrate the Program's results with those at NETL, using simulation as the vehicle for integration and innovation. The investigators also committed to training students in coal utilization technology tuned to the environmental constraints that we face in the future; to this end the Program supported approximately 12 graduate students toward the completion of their graduate degree in addition to numerous undergraduate students. With the increased importance of coal for energy independence, training of graduate and undergraduate students in the development of new technologies is critical.

  13. Radon Research Program, FY 1992

    International Nuclear Information System (INIS)

    The United States Department of Energy, Office of Health and Environmental Research (DOE/OHER) is the principal federal agency conducting basic research related to indoor radon. The scientific information being sought in this program encompasses research designed to determine radon availability and transport outdoors, modeling transport into and within buildings, physics and chemistry of radon and radon progeny, dose response relationships, lung cancer risk, and mechanisms of radon carcinogenesis. There still remains a significant number of uncertainties in the currently available knowledge that is used to estimate lung cancer risk from exposure to environmental levels of radon and its progeny. The main goal of the DOE/OHER Radon Research Program is to develop information to reduce these uncertainties and thereby provide an improved health risk estimate of exposure to radon and its progeny and to identify and understand biological mechanisms of lung cancer development and required copollutants at low levels of exposure. Information useful in radon control strategies is also provided by the basic science undertaken in this program

  14. Asthma and Adolescents: Review of Strategies to Improve Control

    Science.gov (United States)

    Hennessy-Harstad, Ellen

    2013-01-01

    One of every 10 adolescents in the United States has asthma. Adolescents who lack asthma control are at increased risk for severe asthma episodes and death. The National Heart, Lung, and Blood Institute 2007 asthma guidelines and research studies indicated that school nurses are instrumental in assisting adolescents to monitor their asthma, learn…

  15. MINT research reactor safety program

    Energy Technology Data Exchange (ETDEWEB)

    Mohamad Idris bin Taib [Division of Special Project, Malaysian Institute for Nuclear Technology Research (MINT), Bangi (Malaysia)

    2000-11-01

    Malaysian Institute for Nuclear Technology Research (MINT) Research Reactor Safety Program has been done along with Reactor Power Upgrading Project, Reactor Safety Upgrading Project and Development of Expert System for On-Line Nuclear Process Control Project. From 1993 up to date, Neutronic and Thermal-hydraulics analysis, Probabilistic Safety Assessment as well as installation of New 2 MW Secondary Cooling System were done. Installations of New Reactor Building Ventilation System, Reactor Monitoring System, Updating of Safety Analysis Report and Upgrading Primary Cooling System are in progress. For future activities, Reactor Modeling will be included to add present activities. (author)

  16. Asthma: New Information for the Early Interventionist.

    Science.gov (United States)

    Simeonsson, Nancy; And Others

    1995-01-01

    This article highlights key portions of the National Institutes of Health's National Asthma Education Program. Guidelines for understanding asthma triggers and medications are provided, and approaches to controlling environmental factors are suggested. (Author/PB)

  17. Examining intra-rater and inter-rater response agreement: A medical chart abstraction study of a community-based asthma care program

    Directory of Open Access Journals (Sweden)

    Estrabillo Eileen

    2008-05-01

    Full Text Available Abstract Background To assess the intra- and inter-rater agreement of chart abstractors from multiple sites involved in the evaluation of an Asthma Care Program (ACP. Methods For intra-rater agreement, 110 charts randomly selected from 1,433 patients enrolled in the ACP across eight Ontario communities were re-abstracted by 10 abstractors. For inter-rater agreement, data abstractors reviewed a set of eight fictitious charts. Data abstraction involved information pertaining to six categories: physical assessment, asthma control, spirometry, asthma education, referral visits, and medication side effects. Percentage agreement and the kappa statistic (κ were used to measure agreement. Sensitivity and specificity estimates were calculated comparing results from all raters against the gold standard. Results Intra-rater re-abstraction yielded an overall kappa of 0.81. Kappa values for the chart abstraction categories were: physical assessment (κ 0.84, asthma control (κ 0.83, spirometry (κ 0.84, asthma education (κ 0.72, referral visits (κ 0.59 and medication side effects (κ 0.51. Inter-rater abstraction of the fictitious charts produced an overall kappa of 0.75, sensitivity of 0.91 and specificity of 0.89. Abstractors demonstrated agreement for physical assessment (κ 0.88, sensitivity and specificity 0.95, asthma control (κ 0.68, sensitivity 0.89, specificity 0.85, referral visits (κ 0.77, sensitivity 0.88, specificity 0.95, and asthma education (κ 0.49, sensitivity 0.87, specificity 0.77. Conclusion Though collected by multiple abstractors, the results show high sensitivity and specificity and substantial to excellent inter- and intra-rater agreement, assuring confidence in the use of chart abstraction for evaluating the ACP.

  18. Conceiving and Building a Sustainable Research Program.

    Science.gov (United States)

    Scott, James Calvert

    2003-01-01

    Business educators can develop a sustainable research program if they grasp what constitutes well-designed research, recognize the sources of research ideas, know how to refine research ideas, understand how to make a research program integrated and cohesive, realize the importance of replication, and enhance their research productivity using a…

  19. Cooperative IASCC Research (CIR) Program

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, J.L. [Electric Power Research Inst., Palo Alto, CA (United States). Nuclear Power Group

    1998-03-01

    Irradiation assisted stress corrosion cracking (IASCC) describes intergranular environmental cracking of material exposed to ionizing radiation. The implications of IASCC are significant, both in terms of repair and outage costs as well as the potential for cracking in components that may be extremely difficult to repair or replace. Significant advancements have been made in the understanding of IASCC. However, it is clear that major unknowns persist and must be understood and quantified before the life of a reactor component at risk from IASCC can be predicted or significantly extended. Although individual organizations are continuing to effectively address IASCC, it became apparent that a more direct form of cooperation would be more timely and efficient in addressing the technical issues. Thus in 1995 EPRI formed the Cooperative IASCC Research (CIR) Program. This is a cooperative, jointly funded effort with participants from eight countries providing financial support and technical oversight. The efforts of the CIR Program are directed at the highest priority questions in the areas of material susceptibility, water chemistry and material stress. Major research areas of the Program are: (1) evaluation of IASCC mechanisms, (2) development of methodology for predicting IASCC, and (3) quantification of irradiation effects on metallurgy, mechanics and electrochemistry. Studies to evaluate various IASCC mechanisms include work to better understand the possible roles of radiation-induced segregation (RIS), radiation microstructure, bulk and localized deformation effects, overall effects on strength and ductility, hydrogen and helium effects, and others. Experiments are being conducted to isolate individual effects and determine the relative importance of each in the overall IASCC mechanism. Screening tests will be followed by detailed testing to identify the contribution of each effect over a range of conditions. The paper describes the completed and ongoing work being

  20. The Effects of Self-Management Education for School-Age Children on Asthma Morbidity: A Systematic Review

    Science.gov (United States)

    Ahmad, Emily; Grimes, Deanna E.

    2011-01-01

    The effects of asthma self-management education for school-age children on number of school days missed, emergency department visits and hospital admissions were evaluated through a systematic review of the published research. A total of 9 studies on asthma education programs that were conducted in schools by school nurses and health educators and…

  1. Childhood Asthma Prevalence among Puerto Ricans and Mexican Americans: Implications for Behavioral Intervention Research.

    Science.gov (United States)

    Hurtado, A. Magdalena

    1995-01-01

    Data from the Hispanic Health and Nutrition Examination Survey, 1982-84, were used to examine lifetime prevalence (LTP) of childhood asthma among Mexican Americans and Puerto Ricans. LTP was related to Puerto Rican ethnicity, birth outside U.S. mainland, low weight for age, male gender, poverty, urban residence, and single parenthood. Implications…

  2. Childhood Asthma and Environmental Exposures at Swimming Pools: State of the Science and Research Recommendations

    Science.gov (United States)

    Recent studies have explored the potential for swimming pool disinfection byproducts (DBPs) which are respiratory irritants to cause asthma in young children. While these studies raise concerns, gaps still exist in our knowledge regarding the exact causal agents and mechanisms f...

  3. Childhood asthma and environmental exposures at swimming pools: state of the science and research recommendations.

    NARCIS (Netherlands)

    Weisel, C.P.; Richardson, S.D.; Nemery, B.; Aggazzotti, G.; Baraldi, E.; Blatchley, E.R.; Blount, B.C.; Carlsen, K.H.; Eggleston, P.A.; Frimmel, F.H.; Goodman, M.; Gordon, G.; Grinshpun, S.A.; Heederik, D.J.J.; Kogevinas, M.; LaKind, J.S.; Nieuwenhuijsen, M.J.; Piper, F.C.; Sattar, S.A.

    2009-01-01

    OBJECTIVES: Recent studies have explored the potential for swimming pool disinfection by-products (DBPs), which are respiratory irritants, to cause asthma in young children. Here we describe the state of the science on methods for understanding children's exposure to DBPs and biologics at swimming p

  4. Mometasone furoate in the management of asthma: a review

    Directory of Open Access Journals (Sweden)

    Ricardo A Tan

    2008-09-01

    Full Text Available Ricardo A Tan1, Jonathan Corren21California Allergy and Asthma Medical Group, Los Angeles, CA; 2Allergy Research Foundation, Los Angeles, CA, USAAbstract: Inhaled corticosteroids (ICS have proven to be the most effective and essential therapy for the treatment of bronchial asthma. The 2007 National Asthma Education and Prevention Program guidelines recommend ICS as preferred therapy for patients with mild to severe persistent asthma. Mometasone furoate (MF is a relatively new ICS agent with high affinity for the glucocorticoid receptor. It is approved in the US for maintenance treatment of asthma for patients 4 years of age and older. It has been shown to be well tolerated with no significant adverse side effects observed in clinical trials and post-marketing surveillance. The efficacy of mometasone furoate has been established in large, well-designed studies. In patients with persistent asthma previously treated either with short-acting beta-agonists alone or twice-daily maintenance therapy with ICS, once-daily MF has been shown to be superior to placebo in improving lung function, symptom control, and quality of life; and has shown comparable efficacy compared with budesonide, beclomethasone, and fluticasone. Twice-daily dosing with MF has been demonstrated to successfully allow for reduction or elimination of oral corticosteroids in severe asthmatics.Keywords: inhaled steroids, mometasone furoate, once-daily dosing, asthma, stepwise approach

  5. Children with Asthma and Sports

    Directory of Open Access Journals (Sweden)

    Selda Yuzer

    2014-06-01

    Full Text Available Asthma is one of the chronic diseases which have are widely seen among the children. The disease has recently been in the increase all over the world and affects many children. In a study conducted with International Study of Asthma and Allergies in Childhood (ISAAC method, it was found out that prevalence of childhood asthma was 17.1%. Participation in sportive activities by the children with asthma, which is today considered as a part of asthma treatment program, makes contributions to their physical, mental and psychological development and increases their quality of life. The most recommended sports for the children with asthma are swimming and water sports. Sports like tennis and volleyball are too advised. Choice of sports depends on severity of asthma, child and #8217;s choice and whether or not asthma is kept under control. Nursing approaches for the children with asthma include correction of symptoms, training of children and their families, assistance with disease adaptation, continuing asthma care at home and interventions to make children lead healthy activities of daily life of children. With protective measures to be taken by families and children; children should be encourage for sportive activities. [TAF Prev Med Bull 2014; 13(3.000: 241-244

  6. Korean Asthma Guideline 2014: Summary of Major Updates to the Korean Asthma Guideline 2014.

    Science.gov (United States)

    Kim, Deog Kyeom; Park, Yong Bum; Oh, Yeon-Mok; Jung, Ki-Suck; Yoo, Ji Hong; Yoo, Kwang-Ha; Kim, Kwan Hyung

    2016-07-01

    Asthma is a prevalent and serious health problem in Korea. Recently, the Korean Asthma Guideline has been updated by The Korean Academy of Tuberculosis and Respiratory Diseases (KATRD) in an effort to improve the clinical management of asthma. This guideline focuses on adult patients with asthma and aims to deliver up to date scientific evidence and recommendations to general physicians for the management of asthma. For this purpose, this guideline was updated following systematic review and meta-analysis of recent studies and adapting some points of international guidelines (Global Initiative for Asthma [GINA] report 2014, National Asthma Education and Prevention Program [NAEPP] 2007, British Thoracic Society [BTS/SIGN] asthma guideline 2012, and Canadian asthma guideline 2012). Updated issues include recommendations derived using the population, intervention, comparison, and outcomes (PICO) model, which produced 20 clinical questions on the management of asthma. It also covers a new definition of asthma, the importance of confirming various airflow limitations with spirometry, the epidemiology and the diagnostic flow of asthma in Korea, the importance and evidence for inhaled corticosteroids (ICS) and ICS/formoterol as a single maintenance and acute therapy in the stepwise management of asthma, assessment of severity of asthma and management of exacerbation, and an action plan to cope with exacerbation. This guideline includes clinical assessments, and treatment of asthma-chronic obstructive pulmonary disease overlap syndrome, management of asthma in specific conditions including severe asthma, elderly asthma, cough variant asthma, exercise-induced bronchial contraction, etc. The revised Korean Asthma Guideline is expected to be a useful resource in the management of asthma.

  7. The school environment and asthma in childhood

    OpenAIRE

    Hauptman, Marissa; Phipatanakul, Wanda

    2015-01-01

    In this article, we discuss the relationship between environmental exposures within the school environment and pediatric asthma morbidity. This article will conclude by reviewing novel school based asthma education and therapeutic programs and environmental interventions designed to help mitigate pediatric asthma morbidity.

  8. Canadian landmine detection research program

    Science.gov (United States)

    McFee, John E.; Das, Yogadhish; Faust, Anthony A.

    2003-09-01

    Defence R&D Canada (DRDC), an agency within the Department of National Defence, has been conducting research and development (R&D) on the detection of landmines for countermine operations and of unexploded ordnance (UXO) for range clearance since 1975. The Canadian Centre for Mine Action Technologies (CCMAT), located at DRDC Suffield, was formed in 1998 to carry out R&D related to humanitarian demining. The lead group responsible for formulating and executing both countermine and humanitarian R&D programs in detection is the Threat Detection Group at DRDC Suffield. This paper describes R&D for both programs under the major headings of remote minefield detection, close-in scanning detection, confirmation detection and teleoperated systems. Among DRDC's achievements in landmine and UXO detection R&D are pioneering work in electromagnetic and magnetic identification and classification; the first military-fielded multisensor, teleoperated vehicle-mounted landmine detection system; pioneering use of confirmation detectors for multisensor landmine detection systems; the first fielded thermal neutron activation landmine confirmation sensor; the first detection of landmines using a real-time hyperspectral imager; electrical impedance imaging detection of landmines and UXO and a unique neutron backscatter landmine imager.

  9. Precipitating factors of asthma.

    Science.gov (United States)

    Lee, T H

    1992-01-01

    Asthma is characterised by bronchial hyperresponsiveness. This feature of the asthmatic diathesis predisposes patients to wheezing in response to a number of different factors. These precipitating factors include specific allergen acting via sensitised mediator cells through an IgE-dependent mechanism. There are irritants which may work through a non-specific manner, or stimuli such as exercise and hyperventilation, which probably also act through mediator release via a non-IgE-dependent manner. The mechanism whereby physical stimuli such as exercise induce bronchoconstriction is of interest, because it increases the context in which the mast cell may participate in acute asthmatic bronchoconstriction. Respiratory infections also commonly provoke asthma, especially in infants and may, indeed, precipitate the asthmatic state itself. Finally, drugs can often trigger asthma attacks and the mechanisms of asthma precipitated by non-steroidal anti-inflammatory drugs such as aspirin have been the subject of recent research.

  10. Human Research Program Exploration Medical Capability

    Science.gov (United States)

    Barsten, Kristina

    2010-01-01

    NASA s Human Research Program (HRP) conducts and coordinates research projects that provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. The Program is divided into 6 major elements, which a) Provide the Program s knowledge and capabilities to conduct research, addressing the human health and performance risks. b) Advance the readiness levels of technology and countermeasures to the point of transfer to the customer programs and organizations. The National Space Biomedical Research Institute (NSBRI) is a partner with the HRP in developing a successful research program. 3

  11. Effects of a self-management asthma educational program in Taiwan based on PRECEDE-PROCEED model for parents with asthmatic children.

    Science.gov (United States)

    Chiang, Li-Chi; Huang, Jing-Long; Yeh, Kuo-Wei; Lu, Chang-Ming

    2004-04-01

    This study was conducted to evaluate the comparative effectiveness of two different asthma educational programs. One was self-management asthma education based on the PRECEDE-PROCEED model to change the influential factors based on a previous need assessment study in Taiwan. The other consisted of regular outpatient asthma education. The purposes were: 1) to compare differences in the asthma knowledge, self-efficacy, perceived effectiveness, children's cooperation, doctor-patient communication, and self-management behaviors in the experimental and control groups before education, and 2 weeks, 3 months, and 6 months after education; and 2) to compare differences in drug use, medication utilization, asthma severity, signs/symptoms of asthma, school absenteeism, and exercise ability before education, and 2 weeks, 3 months, and 6 months after education. Parents of asthmatic children were recruited from among outpatients of Chang Gung Children's Hospital, Taoyuan, Taiwan. They were grouped by registration number: those with even numbers were assigned to the experimental group, and those with odd numbers were assigned to the control group. Measurements were collected four times from all parents by means of a questionnaire and chart review. The General Linear Model: Repeat Measurement was used to compare variance differences. The following results were found. 1) Asthma knowledge, self-efficacy, perceived effectiveness, children's cooperation, and self-management behaviors significantly improved after the self-management asthma educational program based on PRECEDE-PROCEED. Except for perceived effectiveness, all variables still had good effectiveness after 6 months of follow-up. The experimental group was better than the control group in knowledge, children's cooperation, and self-management behaviors at the 3-month follow up, as well as in knowledge and children's cooperation at the 6-month follow-up. 2) In both the experimental and control groups, the educational program

  12. Interaction between asthma and lung function growth in early life

    DEFF Research Database (Denmark)

    Bisgaard, Hans; Jensen, Signe Marie; Bønnelykke, Klaus

    2012-01-01

    The causal direction between asthma and lung function deficit is unknown, but important for the focus of preventive measures and research into the origins of asthma.......The causal direction between asthma and lung function deficit is unknown, but important for the focus of preventive measures and research into the origins of asthma....

  13. [Asthma, obesity and diet].

    Science.gov (United States)

    Barranco, P; Delgado, J; Gallego, L T; Bobolea, I; Pedrosa, Ma; García de Lorenzo, A; Quirce, S

    2012-01-01

    Asthma and obesity have a considerable impact on public health and their prevalence has increased in recent years. Numerous studies have linked both disorders. Most prospective studies show that obesity is a risk factor for asthma and have found a positive correlation between baseline body mass index (BMI) and the subsequent development of asthma, although these results are not conclusive when studying the association between airway hyperresponsiveness with BMI. Furthermore, several studies suggest that whereas weight gain increases the risk of asthma, weight loss improves the course of the illness. Different factors could explain this association. Obesity is capable of reducing pulmonary compliance, lung volumes and the diameter of peripheral respiratory airways as well as affecting the volume of blood in the lungs and the ventilation-perfusion relationship. Furthermore, the increase in the normal functioning of adipose tissue in obese subjects leads to a systemic proinflammatory state, which produces a rise in the serum concentrations of several cytokines, the soluble fractions of their receptors and chemokines. Many of these mediators are synthesized and secreted by cells from adipose tissue and receive the generic name of adipokines, including IL-6, IL-10, eotaxin, TNF-α, TGF- 1, PCR, leptin y adiponectin. Finally, specific regions of the human genome which are related to both asthma and obesity have been identified. Most studies point out that obesity is capable of increasing the prevalence and incidence of asthma, although this effect appears to be modest. The treatment of obese asthmatics must include a weight control program. PMID:22566313

  14. Facilitating the recruitment of minority ethnic people into research: qualitative case study of South Asians and asthma.

    Directory of Open Access Journals (Sweden)

    Aziz Sheikh

    2009-10-01

    Full Text Available BACKGROUND: There is international interest in enhancing recruitment of minority ethnic people into research, particularly in disease areas with substantial ethnic inequalities. A recent systematic review and meta-analysis found that UK South Asians are at three times increased risk of hospitalisation for asthma when compared to white Europeans. US asthma trials are far more likely to report enrolling minority ethnic people into studies than those conducted in Europe. We investigated approaches to bolster recruitment of South Asians into UK asthma studies through qualitative research with US and UK researchers, and UK community leaders. METHODS AND FINDINGS: Interviews were conducted with 36 researchers (19 UK and 17 US from diverse disciplinary backgrounds and ten community leaders from a range of ethnic, religious, and linguistic backgrounds, followed by self-completion questionnaires. Interviews were digitally recorded, translated where necessary, and transcribed. The Framework approach was used for analysis. Barriers to ethnic minority participation revolved around five key themes: (i researchers' own attitudes, which ranged from empathy to antipathy to (in a minority of cases misgivings about the scientific importance of the question under study; (ii stereotypes and prejudices about the difficulties in engaging with minority ethnic populations; (iii the logistical challenges posed by language, cultural differences, and research costs set against the need to demonstrate value for money; (iv the unique contexts of the two countries; and (v poorly developed understanding amongst some minority ethnic leaders of what research entails and aims to achieve. US researchers were considerably more positive than their UK counterparts about the importance and logistics of including ethnic minorities, which appeared to a large extent to reflect the longer-term impact of the National Institutes of Health's requirement to include minority ethnic people

  15. GA2LEN (Global Allergy and Asthma European Network) addresses the allergy and asthma 'epidemic'.

    Science.gov (United States)

    Bousquet, J; Burney, P G; Zuberbier, T; Cauwenberge, P V; Akdis, C A; Bindslev-Jensen, C; Bonini, S; Fokkens, W J; Kauffmann, F; Kowalski, M L; Lodrup-Carlsen, K; Mullol, J; Nizankowska-Mogilnicka, E; Papadopoulos, N; Toskala, E; Wickman, M; Anto, J; Auvergne, N; Bachert, C; Bousquet, P J; Brunekreef, B; Canonica, G W; Carlsen, K H; Gjomarkaj, M; Haahtela, T; Howarth, P; Lenzen, G; Lotvall, J; Radon, K; Ring, J; Salapatas, M; Schünemann, H J; Szczecklik, A; Todo-Bom, A; Valovirta, E; von Mutius, E; Zock, J P

    2009-07-01

    Allergic diseases represent a major health problem in Europe. They are increasing in prevalence, severity and costs. The Global Allergy and Asthma European Network (GA(2)LEN), a Sixth EU Framework Program for Research and Technological Development (FP6) Network of Excellence, was created in 2005 as a vehicle to ensure excellence in research bringing together research and clinical institutions to combat fragmentation in the European research area and to tackle allergy in its globality. The Global Allergy and Asthma European Network has benefited greatly from the voluntary efforts of researchers who are strongly committed to this model of pan-European collaboration. The network was organized in order to increase networking for scientific projects in allergy and asthma around Europe and to make GA(2)LEN the world leader in the field. Besides these activities, research has also been carried out and the first papers are being published. Achievements of the Global Allergy and Asthma European Network can be grouped as follows: (i) those for a durable infrastructure built up during the project phase, (ii) those which are project-related and based on these novel infrastructures, and (iii) the development and implementation of guidelines. The major achievements of GA(2)LEN are reported in this paper. PMID:19392994

  16. Violence and Asthma: A Review

    Directory of Open Access Journals (Sweden)

    Takeo Fujiwara

    2008-01-01

    Full Text Available Recent research shows that exposure to community violence is, directly and indirectly, associated with asthma. This article reviews the findings on the impact of violence on asthma, and the pathways for the association of violence and asthma are suggested: 1 exposure to violence is directly associated with asthma, mainly through dysregulation of sympathetic-adrenal-medullary (SAM and hypothalamic-pituitary-adrenal (HPA axis, 2 exposure to violence is associated with the change of susceptibility of outdoor air pollution on asthma, probably through the change of an immune response, and 3 behavioral change due to exposure to violence (e.g. keeping children indoors leads to more exposure to indoor pollutants. The suggested framework may be useful to develop health policy on asthma in high-violence communities.

  17. Seismic safety margins research program overview

    International Nuclear Information System (INIS)

    A multiyear seismic research program has been initiated at the Lawrence Livermore Laboratory. This program, the Seismic Safety Margins Research Program (SSMRP) is funded by the U.S. Nuclear Regulatory Commission, Office of Nuclear Regulatory Research. The program is designed to develop a probabilistic systems methodology for determining the seismic safety margins of nuclear power plants. Phase I, extending some 22 months, began in July 1978 at a funding level of approximately $4.3 million. Here we present an overview of the SSMRP. Included are discussions on the program objective, the approach to meet the program goal and objectives, end products, the probabilistic systems methodology, and planned activities for Phase I

  18. Getting control of uncontrolled asthma.

    Science.gov (United States)

    Wechsler, Michael E

    2014-11-01

    Despite various treatment modalities, a large proportion of patients have asthma that remains uncontrolled. These patients remain at an increased risk of developing severe exacerbations, have a poor quality of life, and pose a high economic healthcare burden, with an estimated mean annual cost more than double that of patients with good symptom control. It is therefore important to accurately diagnose asthma and continually assess asthma control. Several validated tools are available to do this, including questionnaires, biomarker analysis, and bronchoscopy. Current guidelines advise physicians to establish a self-management program for the patient to assess and monitor asthma control. A further recommendation is the establishment of an educational action plan to increase treatment adherence and to improve asthma control. National and international guidelines provide long-term management strategies for these patients and recommend a stepwise approach for achieving and maintaining asthma control. Despite availability of a wide range of controller and reliever therapies, uncontrolled asthma remains a challenge and reflects the need for new therapeutic options. This review discusses current global guidelines for the assessment and management of asthma control and summarizes the broad spectrum of novel therapeutic agents currently under development for the treatment of asthma, including anticholinergics, chemoattractant receptor-homologous molecules expressed on T-helper 2 lymphocyte antagonists, and anti-interleukin (IL)-5, anti-IL-13, and anti-IL-4 agents. PMID:24844737

  19. Epidemiologic research program: Selected bibliography

    International Nuclear Information System (INIS)

    This bibliography is a current listing of scientific reports from epidemiologic and related activities sponsored by the Department of Energy. The Office of Epidemiology and Health Surveillance now is the departmental focal point for these activities and any others relating to the study of human health effects. The Office's mission is evolving to encompass the new role of the Department in environmental restoration, weapons dismantlement and nuclear material storage, and development of new energy technologies. Publications in these areas will be included in future editions of the bibliography. The present edition brings the listing up to date, and should facilitate access to specific reports. The program has been divided into several general areas of activity: the Radiation Effects Research Foundation, which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki; mortality and morbidity studies of DOE workers; studies on internally deposited alpha emitters; medical/histologic studies; studies on the genetic aspects of radiation damage; community health surveillance studies; and the development of computational techniques and of databases to make the results as widely useful as possible

  20. Training program attracts work and health researchers

    DEFF Research Database (Denmark)

    Skakon, Janne

    2007-01-01

    to examining work disability prevention issues. An innovative program that attracts international students, the Work Disability Prevention Canadian Institutes of Health Research (CIHR) Strategic Training Program, aims to build research capacity in young researchers and to create a strong network that examines...

  1. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    The programs of the Office of Energy Research, DOE, include several thousand individual projects and hundreds of laboratories, universities, and other research facilities throughout the United States. The major programs and activities are described briefly, and include high energy and nuclear physics, fusion energy, basic energy sciences, and health and environmental research, as well as advisory, assessment, support, and scientific computing activities

  2. AERA Research Training Program 1969. Final Report.

    Science.gov (United States)

    Popham, W. James

    This report describes and evaluates a training program for educational researchers conducted prior to and following the 1969 annual meeting of the American Educational Research Association. The report's description of each of the program's 12 specific training sessions, which served a total of 542 educational researchers, includes the following…

  3. USNRC HTGR safety research program overview

    International Nuclear Information System (INIS)

    An overview is given of current activities and planned research efforts of the US Nuclear Regulatory Commission (NRC) HTGR Safety Program. On-going research at Brookhaven National Laboratory, Oak Ridge National Laboratory, Los Alamos National Laboratory, and Pacific Northwest Laboratory are outlined. Tables include: HTGR Safety Issues, Program Tasks, HTGR Computer Code Library, and Milestones for Long Range Research Plan

  4. LASL's FY 1978 supporting research program

    International Nuclear Information System (INIS)

    This report gives a brief overview of Los Alamos Scientific Laboratory's supporting research program, including philosophy, management and program analysis, funding, and a brief description of the kinds of work currently supported. 10 figures

  5. ANSTO - Program of Research 1993-1994

    International Nuclear Information System (INIS)

    The 1993-1994 Program of Research outlines ANSTO's scientific activities in four key research areas, Advanced Materials, Application of Nuclear Physics, Biomedicine and Health and Environmental Science. The effort has been channeled into applied research and development in partnership with industry and appropriate national and international institutions and into interdisciplinary strategic research projects to enhance the scientific base of the key research activities. A list of scientific publications originated from these program areas is also included. ills

  6. Psychosocial Components of Asthma Management in Children

    OpenAIRE

    Wade, Shari L.

    2000-01-01

    Asthma is a growing health problem that affects 4.8 million children in the US alone. This paper considers empirical studies from the past 20 years examining the relationship between psychosocial factors and asthma management and morbidity. Research indicates that psychosocial factors, including risk and protective factors in the social environment, and knowledge, attitudes and skills pertaining to asthma management, can play an important role in asthma management, adherence and morbidity. Ca...

  7. Progress in the management of childhood asthma

    OpenAIRE

    Vichyanond, Pakit; Pensrichon, Rattana; Kurasirikul, Suruthai

    2012-01-01

    Asthma has become the most common chronic disease in childhood. Significant advances in epidemiological research as well as in therapy of pediatric asthma have been made over the past 2 decades. In this review, we look at certain aspects therapy of childhood asthma, both in the past and present. Literature review on allergen avoidance (including mites, cockroach and cat), intensive therapy with β2-agonists in acute asthma (administering via continuous nebulization and intravenous routes), a r...

  8. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    An overview is given for the DOE research programs in high energy and nuclear physics; fusion energy; basic energy sciences; health and environmental research; and advisory, assessment and support activities

  9. Progeria Research Foundation Diagnostic Testing Program

    Science.gov (United States)

    ... Testing The PRF Diagnostic Testing Program The Progeria Research Foundation, in association with a CLIA-approved diagnostics lab, ... please contact Dr. Leslie Gordon at The Progeria Research Foundation at info@progeriaresearch.org quick links Donate Now ...

  10. Wheezing and Asthma in Infants

    Science.gov (United States)

    ... Cooperate While Using the Nebulizer? Handling an Asthma Flare-Up What's an Asthma Flare-Up? Asthma Center Asthma Basics Managing Asthma When Your ... a Health Problem Asthma Center Handling an Asthma Flare-Up How Do Asthma Medicines Work? Asthma Asthma Center ...

  11. Seismic safety research program plan

    International Nuclear Information System (INIS)

    This plan describes the safety issues, regulatory needs, and the research necessary to address these needs. The plan also discusses the relationship between current and proposed research within the NRC and research sponsored by other government agencies, universities, industry groups, professional societies, and foreign sources

  12. Seismic safety research program plan

    International Nuclear Information System (INIS)

    This document presents a plan for seismic research to be performed by the Structural and Seismic Engineering Branch in the Office of Nuclear Regulatory Research. The plan describes the regulatory needs and related research necessary to address the following issues: uncertainties in seismic hazard, earthquakes larger than the design basis, seismic vulnerabilities, shifts in building frequency, piping design, and the adequacy of current criteria and methods. In addition to presenting current and proposed research within the NRC, the plan discusses research sponsored by other domestic and foreign sources

  13. Research and Development Conference CIEE Program 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    CIEE`s second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director`s discretionary research, and exploratory research will also be featured in this report.

  14. Evaluating the BK 21 Program. Research Brief

    Science.gov (United States)

    Seong, Somi; Popper, Steven W.; Goldman, Charles A.; Evans, David K.; Grammich, Clifford A.

    2008-01-01

    The Brain Korea 21 program (BK21), an effort to improve Korean universities and research, has attracted a great deal of attention in Korea, producing the need to understand how well the program is meeting its goals. RAND developed a logic model for identifying program goals and dynamics, suggested quantitative and qualitative evaluation methods,…

  15. NCI: DCTD: Biometric Research Program: Jianwen Fang

    Science.gov (United States)

    The Biometric Research Program (BRP) is the statistical and biomathematical component of the Division of Cancer Treatment, Diagnosis and Centers (DCTDC). Its members provide statistical leadership for the national and international research programs of the division in developmental therapeutics, developmental diagnostics, diagnostic imaging and clinical trials.

  16. Asthma and allergy - resources

    Science.gov (United States)

    Resources - asthma and allergy ... The following organizations are good resources for information on asthma and allergies : Allergy and Asthma Network Mothers of Asthmatics -- www.aanma.org American Academy of Allergy, Asthma ...

  17. How Is Asthma Diagnosed?

    Science.gov (United States)

    ... page from the NHLBI on Twitter. How Is Asthma Diagnosed? Your primary care doctor will diagnose asthma ... other disease may be causing your symptoms. Diagnosing Asthma in Young Children Most children who have asthma ...

  18. Exercise and Asthma

    Science.gov (United States)

    ... Issues Listen Español Text Size Email Print Share Exercise and Asthma Page Content Article Body Almost every ... children more likely to develop asthma. How does exercise cause asthma symptoms? The symptoms of asthma are ...

  19. Extreme Programming in a Research Environment

    Science.gov (United States)

    Wood, William A.; Kleb, William L.

    2002-01-01

    This article explores the applicability of Extreme Programming in a scientific research context. The cultural environment at a government research center differs from the customer-centric business view. The chief theoretical difficulty lies in defining the customer to developer relationship. Specifically, can Extreme Programming be utilized when the developer and customer are the same person? Eight of Extreme Programming's 12 practices are perceived to be incompatible with the existing research culture. Further, six of the nine 'environments that I know don't do well with XP' apply. A pilot project explores the use of Extreme Programming in scientific research. The applicability issues are addressed and it is concluded that Extreme Programming can function successfully in situations for which it appears to be ill-suited. A strong discipline for mentally separating the customer and developer roles is found to be key for applying Extreme Programming in a field that lacks a clear distinction between the customer and the developer.

  20. Occupational asthma

    Science.gov (United States)

    ... occupational exposure; Irritant-induced reactive airways disease Images Spirometry Respiratory system References Lemiere C, Vandenplas O. Occupational allergy and asthma. In: Adkinson NF Jr., Bochner BS, Burks AW, ...

  1. What Works for Asthma Education Programs: Lessons from Experimental Evaluations of Social Programs and Interventions for Children. Fact Sheet. Publication #2012-01

    Science.gov (United States)

    Chrisler, Alison

    2012-01-01

    Asthma is a chronic respiratory disease that affects millions of children and adolescents each year. In 2009, 7.1 million children ages 0 to 17 years were reported to have asthma. Unfortunately, when children and teens are unable to manage and cope with their disease, it can compromise their physical, academic, and social development. Therefore,…

  2. Implementation of a 12-week disease management program improved clinical outcomes and quality of life in adults with asthma in a rural district hospital: pre- and post-intervention study.

    Science.gov (United States)

    Chamnan, Parinya; Boonlert, Kittipa; Pasi, Wanit; Yodsiri, Songkran; Pong-on, Sirinya; Khansa, Bhoonsab; Yongkulwanitchanan, Pichapat

    2010-03-01

    Despite the availability of effective medical treatment and disease management guidelines, asthma remains a poorly controlled disease in developing countries. There is little evidence of the effectiveness of disease management guidelines in rural clinical practice. The effect of disease management guidelines on clinical outcomes and quality of life in asthmatic patients in a rural community hospital was examined. Fifty-seven patients aged > or = 16 years with physician-diagnosed asthma from a hospital outpatient clinic in Ubon-ratchathani, Thailand, were recruited. Asthma diagnosis was confirmed by reviewing clinical records. We implemented a 12-week disease management program, including the use of written asthma treatment plan and asthma action plan tailored to individual patients. Using one-group pre- and post-intervention design, we compared the average number of emergency visits and hospitalizations from acute asthmatic attacks before and after the implementation of interventions using the Wilcoxon matched-pairs signed-rank test. We also compared patient's asthma quality of life (AQL) scores, measured using the 7-point scaled Mini Asthma Quality of Life Questionnaire. It was found that among the 57 patients, 38 (67%) were women, and the mean age (SD) of the patients was 47.6 (17.0) years. Sixteen patients (28%) had a family history of asthma. Emergency visits decreased from 0.48 (SD = 0.83) per patient before implementation of interventions to 0.11 (0.37) per patient after implementation of interventions (p = 0.003). Hospitalizations with acute asthma attacks reduced from 0.14 (0.35) per patient to 0.04 (0.27) per patient (p = 0.034). Overall AQL scores increased significantly from 3.7 to 5.4 (p management program could reduce emergency visits and hospitalizations, and improve patients' quality of life in a rural practice setting.

  3. Lewis' Educational and Research Collaborative Internship Program

    Science.gov (United States)

    Heyward, Ann; Gott, Susan (Technical Monitor)

    2004-01-01

    The Lewis Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships in addition to summer and winter extensions if funding is available and/or is requested by mentor (no less than 1 week no more than 4 weeks) for undergraduate/graduate students and secondary school teachers. Students who meet the travel reimbursement criteria receive up to $500 for travel expenses. Approximately 178 interns are selected to participate in this program each year and begin arriving the fourth week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, and lectures. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds. The purpose of this report is to document the program accomplishments for 2004.

  4. THE EFFECT OF SELECTED EXERCISE PROGRAM AND CONSUMPTION OF VITAMIN D SUPPLEMENTATION ON PEACE OF PATIENTS WITH ASTHMA

    OpenAIRE

    Mohammad Reza Kordi; Parvaneh Nazarali; Zeynab Razavi Majd; Parichehr Hanachi

    2011-01-01

    The aim of this research; determine of the effect aerobic exercise training program andconsumption Vitamin D supplement on Forced Expiratory Volume in First second(FEV1) inAsthmatic patients.16 Asthmatic patients(8 person in exercise group & 8 person control group)were selected. Asthmatic patients’ group exercise has under taken 8-week aerobic exercisetraining program and consumption Vitamin D supplement and control group have not program.Borg scale for perceived exertion was employed for sel...

  5. Environmental research program: FY 1987, annual report

    Energy Technology Data Exchange (ETDEWEB)

    1988-03-01

    This multidisciplinary research program includes fundamental and applied research in physics, chemistry, engineering, and biology, as well as research on the development of advanced methods of measurement and analysis. The Program's Annual Report contains summaries of research performed during FY 1987 in the areas of atmospheric aerosols, flue gas chemistry, combustion, membrane bioenergetics, and analytical chemistry. The main research interests of the Atmospheric Aerosol Research group concern the chemical and physical processes that occur in haze, clouds, and fogs. For their studies, the group is developing novel analytical and research methods for characterizing aerosol species. Aerosol research is performed in the laboratory and in the field. Studies of smoke emissions from fires and their possible effects on climatic change, especially as related to nuclear winter, are an example of the collaboration between the Atmospheric Aerosol Research and Combustion Research Groups.

  6. Environmental research program: FY 1987, annual report

    International Nuclear Information System (INIS)

    This multidisciplinary research program includes fundamental and applied research in physics, chemistry, engineering, and biology, as well as research on the development of advanced methods of measurement and analysis. The Program's Annual Report contains summaries of research performed during FY 1987 in the areas of atmospheric aerosols, flue gas chemistry, combustion, membrane bioenergetics, and analytical chemistry. The main research interests of the Atmospheric Aerosol Research group concern the chemical and physical processes that occur in haze, clouds, and fogs. For their studies, the group is developing novel analytical and research methods for characterizing aerosol species. Aerosol research is performed in the laboratory and in the field. Studies of smoke emissions from fires and their possible effects on climatic change, especially as related to nuclear winter, are an example of the collaboration between the Atmospheric Aerosol Research and Combustion Research Groups

  7. Accreditation to manage research programs

    International Nuclear Information System (INIS)

    In this report for an accreditation to supervise research, the author proposes an overview of a study of transfers of vanadium towards benthic organisms (i.e. the toxicity of vanadium for sea coastal organisms), of studies of transfer of transuranic elements from sediment to marine benthic species. He presents current researches and perspectives: study of the level of metallic pollutants and physical-chemical characteristics of coastal waters in northern Cotentin, researches in Seine Bay, study of pollution biologic indicators. Numerous articles are provided in appendix

  8. Maryland controlled fusion research program

    International Nuclear Information System (INIS)

    In this paper, we summarize the technical progress in four major areas of tokamak research: (a) L/H transition and edge turbulence and transport; (b) active control of microturbulence and transport; (c) major disruptions; and (d) the sawtooth crash

  9. Maryland controlled fusion research program

    Energy Technology Data Exchange (ETDEWEB)

    Griem, H.R.; Liu, C.S.

    1992-01-01

    In this paper, we summarize the technical progress in four major areas of tokamak research: (a) L/H transition and edge turbulence and transport; (b) active control of microturbulence and transport; (c) major disruptions; and (d) the sawtooth crash.

  10. Epidemiological & Risk Factors In Childhood Bronchial Asthma

    Directory of Open Access Journals (Sweden)

    Singh Harmesh

    1998-01-01

    Full Text Available Research question: What are the epidemiological and risk factors associated with asthma in children. Objective: To determine epidemiological and risk factors in childhood bronchial asthma. Study design: Cross-sectional. Setting Hospital based. Participants: Children suffering from bronchial asthma and their parents/ attendants. Sample size: 235 children. Study variables: Age, sex place of residence, socio-economic status, age of onset of asthma, no of siblings, fuel used for cooking, smoking, asthma in the family seasonal variation etc. Statistical analysis: percentages

  11. Theoretical Particle Physics Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Paz, Gil [Wayne State Univ., Detroit, MI (United States)

    2015-06-23

    This is the final technical report for DOE grant DE-FG02-13ER41997. It contains a brief description of accomplishments: research project that were completed during the period of the grant, research project that were started during the period of the grant, and service to the scientific community. It also lists the publications in the funded period, travel related to the grant, and information about the personal supported by the grant.

  12. Prenatal Stress, Prematurity, and Asthma.

    Science.gov (United States)

    Medsker, Brock; Forno, Erick; Simhan, Hyagriv; Celedón, Juan C

    2015-12-01

    Asthma is the most common chronic disease of childhood, affecting millions of children in the United States and worldwide. Prematurity is a risk factor for asthma, and certain ethnic or racial minorities such as Puerto Ricans and non-Hispanic blacks are disproportionately affected by both prematurity and asthma. In this review, we examine current evidence to support maternal psychosocial stress as a putative link between prematurity and asthma, while also focusing on disruption of the hypothalamic-pituitary-adrenal (HPA) axis and immune responses as potential underlying mechanisms for stress-induced "premature asthma." Prenatal stress may cause not only abnormalities in the HPA axis but also epigenetic changes in the fetal glucocorticoid receptor gene (NR3C1), leading to impaired glucocorticoid metabolism. Moreover, maternal stress can alter fetal cytokine balance, favoring TH2 (allergic) immune responses characteristic of atopic asthma: interleukin 6 (IL-6), which has been associated with premature labor, can promote TH2 responses by stimulating production of IL-4 and IL-13. Given a link among stress, prematurity, and asthma, future research should include birth cohorts aimed at confirming and better characterizing "premature asthma." If confirmed, clinical trials of prenatal maternal stress reduction would be warranted to reduce the burden of these common comorbidities. While awaiting the results of such studies, sound policies to prevent domestic and community violence (eg, from firearms) are justified, not only by public safety but also by growing evidence of detrimental effects of violence-induced stress on psychiatric and somatic health.

  13. Prenatal Stress, Prematurity, and Asthma.

    Science.gov (United States)

    Medsker, Brock; Forno, Erick; Simhan, Hyagriv; Celedón, Juan C

    2015-12-01

    Asthma is the most common chronic disease of childhood, affecting millions of children in the United States and worldwide. Prematurity is a risk factor for asthma, and certain ethnic or racial minorities such as Puerto Ricans and non-Hispanic blacks are disproportionately affected by both prematurity and asthma. In this review, we examine current evidence to support maternal psychosocial stress as a putative link between prematurity and asthma, while also focusing on disruption of the hypothalamic-pituitary-adrenal (HPA) axis and immune responses as potential underlying mechanisms for stress-induced "premature asthma." Prenatal stress may cause not only abnormalities in the HPA axis but also epigenetic changes in the fetal glucocorticoid receptor gene (NR3C1), leading to impaired glucocorticoid metabolism. Moreover, maternal stress can alter fetal cytokine balance, favoring TH2 (allergic) immune responses characteristic of atopic asthma: interleukin 6 (IL-6), which has been associated with premature labor, can promote TH2 responses by stimulating production of IL-4 and IL-13. Given a link among stress, prematurity, and asthma, future research should include birth cohorts aimed at confirming and better characterizing "premature asthma." If confirmed, clinical trials of prenatal maternal stress reduction would be warranted to reduce the burden of these common comorbidities. While awaiting the results of such studies, sound policies to prevent domestic and community violence (eg, from firearms) are justified, not only by public safety but also by growing evidence of detrimental effects of violence-induced stress on psychiatric and somatic health. PMID:26676148

  14. Environment and asthma in adults.

    Science.gov (United States)

    Le Moual, Nicole; Jacquemin, Bénédicte; Varraso, Raphaëlle; Dumas, Orianne; Kauffmann, Francine; Nadif, Rachel

    2013-09-01

    The present review addresses recent advances and especially challenging aspects regarding the role of environmental risk factors in adult-onset asthma, for which the causes are poorly established. In the first part of the review, we discuss aspects regarding some environmental risk factors for adult-onset asthma: air pollution, occupational exposures with a focus on an emerging risk represented by exposure to cleaning agents (both at home and in the workplace), and lifestyle and nutrition. The second part is focused on perspectives and challenges, regarding relevant topics on which research is needed to improve the understanding of the role of environmental factors in asthma. Aspects of exposure assessment, the complexity of multiple exposures, the interrelationships of the environment with behavioral characteristics and the importance of studying biological markers and gene-environment interactions to identify the role of the environment in asthma are discussed. We conclude that environmental and lifestyle exposures play an important role in asthma or related phenotypes. The changes in lifestyle and the environment in recent decades have modified the specific risk factors in asthma even for well-recognized risks such as occupational exposures. To better understand the role of the environment in asthma, the use of objective (quantitative measurement of exposures) or modern tools (bar code, GPS) and the development of multidisciplinary collaboration would be very promising. A better understanding of the complex interrelationships between socio-economic, nutritional, lifestyle and environmental conditions might help to study their joint and independent roles in asthma.

  15. Summer Undergraduate Research Program: Environmental studies

    Energy Technology Data Exchange (ETDEWEB)

    McMillan, J. [ed.

    1994-12-31

    The purpose of the summer undergraduate internship program for research in environmental studies is to provide an opportunity for well-qualified students to undertake an original research project as an apprentice to an active research scientist in basic environmental research. The students are offered research topics at the Medical University in the scientific areas of pharmacology and toxicology, epidemiology and risk assessment, environmental microbiology, and marine sciences. Students are also afforded the opportunity to work with faculty at the University of Charleston, SC, on projects with an environmental theme. Ten well-qualified students from colleges and universities throughout the eastern United States were accepted into the program.

  16. Overview of Gas Research Institute environmental research programs

    International Nuclear Information System (INIS)

    The Gas Research Institute (GRI) is a private not-for-profit membership organization of natural gas pipelines, distribution companies and natural gas producers. GRI's purpose is to plan, to manage and to develop financing for a gas-related research and development (R and D) program on behalf of its members and their customers. GRI does not do any research itself. GRI's R and D program is designed to provide advanced technologies for natural gas supply, transport, storage, distribution and end-use applications in all markets. In addition, basic research is conducted for GRI in these areas to build a foundation for future technology breakthroughs. Work in the Environment and Safety Research Department includes sections interested in: supply related research, air quality research, end use equipment safety research, gas operations safety research, and gas operations environmental research. The Natural Gas Supply Program has research ongoing in such areas as: restoration of pipeline right-of-ways; cleaning up town gas manufacturing sites; the development of methanogenic bacteria for soil and groundwater cleanup; development of biological fluidized carbon units for rapid destruction of carbonaceous compounds; research on liquid redox sulfur recovery for sulfur removal from natural gas; research on produced water and production wastes generated by the natural gas industry; environmental effects of coalbed methane production; and subsurface effects of natural gas operations. The western coalbed methane and ground water programs are described

  17. 糖皮质激素在支气管哮喘治疗中的进展%Research advances on treatment of glncocorticoid in bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    余力; 谢正福

    2008-01-01

    支气管哮喘(简称哮喘)是由多种免疫细胞(如肥大细胞、嗜酸粒细胞、T细胞、中性粒细胞、气道上皮细胞等)和细胞组分参与的变态反应性疾病.目前哮喘的药物治疗中主要包括糖皮质激素,很多研究从糖皮质激素治疗哮喘的机制着手,探讨其作用于哮喘的多个环节.%Bronchial asthma(asthma) is an allergic disorder of lung participated by many sorts of immunocytes and cellular components. Current pharmaceutical treatments for asthma generally include the glucocorticoid,and lots of researches go to further the mechanism of glucocorticoid action,all those results will hopefully approach to the effect on component elements of asthma.

  18. Environmental research program. 1992 annual report

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    The objective of the Environmental Research Program is to contribute to the understanding of the formation, mitigation, transport, transformation, and ecological effects of energy-related pollutants on the environment. The program is multidisciplinary and includes fundamental and applied research in chemistry, physics, biology, engineering, and ecology. The program undertakes research and development in efficient and environmentally benign combustion, pollution abatement and destruction, and novel methods of detection and analysis of criteria and non-criteria pollutants. This diverse group investigates combustion, atmospheric processes, flue-gas chemistry, and ecological systems.

  19. University Research Consortium annual review meeting program

    International Nuclear Information System (INIS)

    This brochure presents the program for the first annual review meeting of the University Research Consortium (URC) of the Idaho National Engineering Laboratory (INEL). INEL is a multiprogram laboratory with a distinctive role in applied engineering. It also conducts basic science research and development, and complex facility operations. The URC program consists of a portfolio of research projects funded by INEL and conducted at universities in the United States. In this program, summaries and participant lists for each project are presented as received from the principal investigators

  20. University Research Consortium annual review meeting program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    This brochure presents the program for the first annual review meeting of the University Research Consortium (URC) of the Idaho National Engineering Laboratory (INEL). INEL is a multiprogram laboratory with a distinctive role in applied engineering. It also conducts basic science research and development, and complex facility operations. The URC program consists of a portfolio of research projects funded by INEL and conducted at universities in the United States. In this program, summaries and participant lists for each project are presented as received from the principal investigators.

  1. Natural and accelerated bioremediation research program plan

    International Nuclear Information System (INIS)

    This draft plan describes a ten-year program to develop the scientific understanding needed to harness and develop natural and enhanced biogeochemical processes to bioremediate contaminated soils, sediments and groundwater at DOE facilities. The Office of Health and Environmental Research (OHER) developed this program plan, with advice and assistance from DOE's Office of Environmental Management (EM). The program builds on OHER's tradition of sponsoring fundamental research in the life and environmental sciences and was motivated by OHER's and Office of Energy Research's (OER's) commitment to supporting DOE's environmental management mission and the belief that bioremediation is an important part of the solution to DOE's environmental problems

  2. 2016 Research Outreach Program report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hye Young [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kim, Yangkyu [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-13

    This paper is the research activity report for 4 weeks in LANL. Under the guidance of Dr. Lee, who performs nuclear physics research at LANSCE, LANL, I studied the Low Energy NZ (LENZ) setup and how to use the LENZ. First, I studied the LENZ chamber and Si detectors, and worked on detector calibrations, using the computer software, ROOT (CERN developed data analysis tool) and EXCEL (Microsoft office software). I also performed the calibration experiments that measure alpha particles emitted from a Th-229 source by using a S1-type detector (Si detector). And with Dr. Lee, we checked the result.

  3. Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007.

    Science.gov (United States)

    2007-11-01

    instructions for daily treatment and ways to recognize and handle worsening asthma. New recommendations encourage expanding educational opportunities to reach patients in a variety of settings, such as pharmacies, schools, community centers, and patients' homes. A new section addresses the need for clinician education programs to improve communication with patients and to use system-wide approaches to integrate the guidelines into health care practice. The guidelines describe new evidence for using multiple approaches to limit exposure to allergens and other substances that can worsen asthma; research shows that single steps are rarely sufficient. EPR-3 also expands the section on common conditions that can affect asthma and notes that management of these conditions may help to improve asthma control. Expert Panel Report 3 continues the use of a stepwise approach to control asthma. When assessing the level of asthma control to determine the need for adjusting therapy, EPR-3 reconfirms the importance of assessing patient adherence to medication, inhaler technique, and environmental control measures before making a step up in therapy. The stepwise approach expands from 4 steps to 6 steps of care. Medications have been repositioned within these 6 steps. Recommendations on medications are updated to reflect the latest evidence on effectiveness and safety. EPR-3 reaffirms that patients with persistent asthma need both long-term control medications to control asthma and prevent exacerbations and quick-relief medication for symptoms, as needed. EPR-3 also reaffirms that inhaled corticosteroids are the most effective long-term control medication across all age groups. New recommendations on treatment options such as leukotriene receptor antagonists and cromolyn for long-term control; long-acting beta-agonists as adjunct therapy with inhaled corticosteroids; omalizumab for severe asthma; and albuterol, levalbuterol, and corticosteroids for acute exacerbations are included. PMID

  4. Small business innovation research program solicitation

    Science.gov (United States)

    1994-01-01

    The National Aeronautics and Space Administration invites eligible small business concerns to submit Phase 1 proposals for its 1994 Small Business Innovation Research (SBIR) Program, which is described in this twelfth annual NASA SBIR Program Solicitation. The 1994 solicitation period for Phase 1 proposals begins April 4, 1994 and ends June 15, 1994. Eligible firms with research or research and development capabilities (R/R&D) in any of the listed topic and subtopic areas are encouraged to participate. Through SBIR, NASA seeks innovative concepts addressing the program needs described in the SBIR solicitation subtopics and offering commercial application potential. This document contains program background information, outlines eligibility requirements for SBIR participants, describes the three SBIR program phases, and provides the information qualified offerors need to prepare and submit responsive proposals.

  5. Breast Cancer and the Environment Research Program

    Science.gov (United States)

    The Breast Cancer and the Environment Research Program supports a multidisciplinary network of scientists, clinicians, and community partners to examine the effects of environmental exposures that may predispose a woman to breast cancer throughout her life.

  6. Environmental Research Division's Data Access Program (ERDDAP)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — ERDDAP (the Environmental Research Division's Data Access Program) is a data server that gives you a simple, consistent way to download subsets of scientific...

  7. Human Research Program Integrated Research Plan. Revision A January 2009

    Science.gov (United States)

    2009-01-01

    The Integrated Research Plan (IRP) describes the portfolio of Human Research Program (HRP) research and technology tasks. The IRP is the HRP strategic and tactical plan for research necessary to meet HRP requirements. The need to produce an IRP is established in HRP-47052, Human Research Program - Program Plan, and is under configuration management control of the Human Research Program Control Board (HRPCB). Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological and behavioral effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes HRP s approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and how they are integrated to provide a risk mitigation tool. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

  8. Research and Development Conference CIEE Program 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    CIEE's second annual Research and Development Conference will introduce you to some of the results achieved to date through CIEE-sponsored multiyear research performed in three programs: Building Energy Efficiency, Air Quality Impacts of Energy Efficiency, and End-Use Resource Planning. Results from scoping studies, Director's discretionary research, and exploratory research will also be featured in this report.

  9. Localizing Transnational Composition Research and Program Design

    Science.gov (United States)

    Zenger, Amy

    2016-01-01

    As an American-trained compositionist working in the Middle East, Amy Zenger questioned the ways she and others in her position conduct research and construct, revise, or administer composition programs outside of the U.S., particularly when these programs purport to adhere to American models of liberal arts education. Universities and programs…

  10. NASA Small Business Innovation Research program

    Science.gov (United States)

    Johnson, Harry W.

    1985-01-01

    NASA activities in the framework of the 11-agency federal Small Business Innovation Research program are outlined in tables and graphs and briefly characterized. Statistics on the program are given; the technical topics covered are listed; and the procedures involved in evaluating applications for support are discussed. A number of typical defects in proposals are indicated, and recommendations for avoiding them are provided.

  11. AECL programs in basic physics research

    International Nuclear Information System (INIS)

    This report describes the CRNL program of research into the basic properties of atomic nuclei and condensed matter (liquids and solids). Brief descriptions are given of some of the current experimental programs done principally at the NRU reactor and MP tandem accelerator, the associated theoretical studies, and some highlights of past achievements

  12. New energy technologies. Research program proposition

    International Nuclear Information System (INIS)

    This document presents the most promising program propositions of research and development and the public financing needed for their realization. The concerned technologies are: the hydrogen and the fuel cell PAN-H, the separation and the storage of the CO2, the photovoltaic solar electricity, the PREBAT program of the building energy recovery and the bio-energies. (A.L.B.)

  13. AECL programs in advanced systems research

    International Nuclear Information System (INIS)

    The AECL program in advanced systems research is directed in the long term to securing the option of obtaining fissile fuel by electronuclear breeding (accelerator breeder or fusion breeder) and to providing a basis from which AECL might move into stand alone fusion energy if warranted. In the short term the program is directed to reaping benefits from electronuclear technology. This report outlines the main activities and research facilities in both the long-term and short-term subprograms

  14. The research progress of the relationship between vitamin A and asthma%维生素A与哮喘关系的研究进展

    Institute of Scientific and Technical Information of China (English)

    庄丽丽

    2015-01-01

    Vitamin A deficiency is a risk factor for asthma.Vitamin A plays important roles in maintaining airway epithelium phenotype,suppressing airway hyperresponsiveness,inducing immune tolerance and regulating airway inflammation,etc.The value of Vitamin A in asthma prevention and treatment has received wild attention but is still controverial.Vitamin A receptors are wildly expressed and the mechanisms are complex,more studies are needed to further clarify the relationship between Vitamin A and asthma.Besides,asthma is a polygenetic disease caused by environmental and genetic factors,and the current clinical studies of Vitamin A for prevention and treatment of asthma are not consistent.New epidemiologic studies about Vitamin A and asthma should take environmental and genetic factors into consideration.This article gives an overview about the research progress of the relationship between Vitamin A and asthma.%维生素A缺乏是哮喘发病的危险因素之一.维生素A具有拮抗气道氧化性损伤、促进气道损伤的修复、抑制气道高反应、诱导免疫耐受、调节气道炎症等功能.维生素A用于哮喘防治成为研究热点,但其效益性仍存在争议.维生素A的受体广泛表达、信号通路复杂,维生素A与哮喘发病相关机制有待更深入的研究.目前,维生素A用于哮喘防治的临床研究已有报道,但结果尚不一致.哮喘是一种由环境和遗传因素共同作用的多基因遗传病,今后维生素A用于哮喘防治的基础和临床研究可结合遗传和环境的群体差异.该文就维生素A与哮喘关系的研究进展进行综述.

  15. Research Progress of the Pathogenesis of Bronchial Asthma%支气管哮喘发病机制的研究进展

    Institute of Scientific and Technical Information of China (English)

    李学良; 许朝霞; 王忆勤

    2012-01-01

    随着分子免疫学和分子遗传学的发展,人们对支气管哮喘发病机制的研究有了进一步发展.中医学认为,哮喘属于中医哮病范畴,痰阻气道、气机失调为本病的基本病机.现代医学认为TH1/TH2类细胞因子失衡、细胞因子、基质金属蛋白酶( matrix metalloproteinase,MMP)及其组织抑制剂(tissue inhibitor of metalloproteinase,TIMP)、遗传学因素、神经调节等在哮喘的发生发展过程中起着重要作用.阐明哮喘的发病机制,能为其治疗提供依据.%With the development of molecular immunology and molecular genetics, the research on the pathogenesis of bronchial asthma has been further developed. Chinese medicine believes that asthma belongs to the Wheezing illness. The etiology and pathogenesis of asthma are the sputum obstructing airway and qi imbalance. Modern medicine believes that the imbalance of cytokines TH1/TH2,cytokines,matrix metalloproteinase( MMP)and its tissue inhibitor of metalloprotein-ase(TIMP) ,genetic factors, neural regulation, et al,plays an important role in the development and progression of asthma. Clarifying the pathogenesis of asthma can provide the basis for its treatment.

  16. GAS INDUSTRY GROUNDWATER RESEARCH PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    James A. Sorensen; John R. Gallagher; Steven B. Hawthorne; Ted R. Aulich

    2000-10-01

    The objective of the research described in this report was to provide data and insights that will enable the natural gas industry to (1) significantly improve the assessment of subsurface glycol-related contamination at sites where it is known or suspected to have occurred and (2) make scientifically valid decisions concerning the management and/or remediation of that contamination. The described research was focused on subsurface transport and fate issues related to triethylene glycol (TEG), diethylene glycol (DEG), and ethylene glycol (EG). TEG and DEG were selected for examination because they are used in a vast majority of gas dehydration units, and EG was chosen because it is currently under regulatory scrutiny as a drinking water pollutant. Because benzene, toluene, ethylbenzene, and xylenes (collectively referred to as BTEX) compounds are often very closely associated with glycols used in dehydration processes, the research necessarily included assessing cocontaminant effects on waste mobility and biodegradation. BTEX hydrocarbons are relatively water-soluble and, because of their toxicity, are of regulatory concern. Although numerous studies have investigated the fate of BTEX, and significant evidence exists to indicate the potential biodegradability of BTEX in both aerobic and anaerobic environments (Kazumi and others, 1997; Krumholz and others, 1996; Lovely and others, 1995; Gibson and Subramanian, 1984), relatively few investigations have convincingly demonstrated in situ biodegradation of these hydrocarbons (Gieg and others, 1999), and less work has been done on investigating the fate of BTEX species in combination with miscible glycols. To achieve the research objectives, laboratory studies were conducted to (1) characterize glycol related dehydration wastes, with emphasis on identification and quantitation of coconstituent organics associated with TEG and EG wastes obtained from dehydration units located in the United States and Canada, (2) evaluate

  17. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    The purpose of this research has been to support the energy technology development programs by providing insight into fundamental science and associated phenomena and developing new or advanced concepts and techniques. Today, this responsibility rests with the Office of Energy Research (ER), DOE, whose present programs have their origins in pioneering energy-related research which was initiated nearly 40 years ago. The Director, Office of Energy Research, also acts as the chief scientist and scientific advisor to the Secretary of Energy for the entire spectrum of energy research and development (R and D) programs of the Department. ER programs include several thousand individual projects and hundreds of laboratories, universities, and other research facilities throughout the United States. The current organization of ER is shown. The budgets for the various ER programs for the last two fiscal years are shown. In the following pages, each of these programs and activities are described briefly for the information of the scientific community and the public at large

  18. FDA's recommendations on the use of long-acting {beta}2 agonists in the management of asthma.

    Science.gov (United States)

    Robinson, Christie A

    2010-10-01

    The revised labeling for long-acting β(2) agonists (LABAs) by the Food and Drug Administration (FDA) is controversial and in part is inconsistent with the 2007 National Asthma Education and Prevention Program asthma guidelines. Two large randomized controlled studies, the Serevent Nationwide Surveillance (SNS) study and the Salmeterol Multicenter Asthma Research Trial (SMART), and a 2008 meta-analysis conducted by the FDA were the main sources of information used to determine the label changes. A paucity of large, well-designed, controlled, prospective studies evaluating the asthma-related risks associated with LABAs makes it difficult to reach a consensus regarding how best to use LABAs in patients with asthma. PMID:20841520

  19. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    The programs of the Office of Energy Research provide basic science support for energy technologies as well as advancing understanding in general science and training future scientists. Energy Research provides insights into fundamental science and associated phenomena and develops new or advanced concepts and techniques. Research of this type has been supported by the Department of Energy and its predecessors for over 40 years and includes research in the natural and physical sciences, including high energy and nuclear physics; magnetic fusion energy; biological and environmental research; and basic energy sciences research in the materials, chemical, and applied mathematical sciences, engineering and geosciences, and energy biosciences. These basic research programs help build the science and technology base that underpins energy development by Government and industry

  20. Bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008049 Activation ralated genes of memory CD+4 T cells in asthma patients. PI Weifeng(皮卫峰),et al. Dept Respir Med, Xinhua Hosp, Sch Med, Shanghai Jiaotong Univ, Shanghai 200092. Chin J Tuberc Respir Dis 2007;30(12):932-935. Objective To screen and identify the genes of activated memory CD+4 T cells in asthma. Methods Differential display polymerase chain reaction(DDPCR) was utilized to identify genes of memory CD+4 T cells after activation from asthmatic patients and normal individuals,

  1. Creating an Asthma-Friendly School

    Centers for Disease Control (CDC) Podcasts

    2007-11-08

    This podcast features real-life success stories of students with asthma who, thanks to their schools' implementation of asthma-friendly policies and programs, now have their asthma under control.  Created: 11/8/2007 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Adolescent and School Health (DASH).   Date Released: 5/20/2008.

  2. Regulatory research program for 1987/88

    International Nuclear Information System (INIS)

    The regulatory research program of Canada's Atomic Energy Control Board (AECB) is intended to augment the AECB's research program beyond the capability of in-house resources. The overall objective of the research program is to produce pertinent and independent information that will assist the Board and its staff in making correct, timely and credible decisions on regulating nuclear energy. The program covers the following areas: the safety of nuclear facilities, radioactive waste management, health physics, physical security, and the development of regulatory processes. Sixty-seven projects are planned for 1987/88; as well, there are some projects held in reserve in case funding becomes available. This information bulletin contains a list of the projects with a brief description of each

  3. Multitechnology and supporting research programs

    International Nuclear Information System (INIS)

    This section includes research efforts that provide information applicable to several presently operating technologies as well as those being investigated for the future. In these technologies the nature of the environmental problem is equally applicable to any one technology; e.g., thermal and chemical pollution of water due to operation of steam electric plants, whether nuclear, fossil fuel, or gas fired; or, the statistical design needed for differentiating a general background of industrial pollution from the contributions, if any, arising from operation of an energy facility. The two main groups of projects reported include biomathematical methods for the analysis of natural systems and the quantitative ecology of impact evaluation; and aquatic ecological studies including the effects of water quality alterations on fish behavior; the ecological effects of combined aquatic stressors; the effects of energy systems effluents on coastal ecosystems; the bioavailability of energy effluent materials in coastal ecosystems; the marine chemistry of energy-generated pollutants; and methods for in situ measurement of pollutants

  4. Core Research Program, Year 5

    Science.gov (United States)

    2002-01-01

    Dramatic losses of bone mineral density (BMD) and muscle strength are two of the best documented changes observed in humans after prolonged exposure to microgravity. Recovery of muscle upon return to a 1-G environment is well studied, however, far less is known about the rate and completeness of BMD recovery to pre-flight values. Using the mature tail-suspended adult rat model, this proposal will focus on the temporal course of recovery in tibial bone following a 28-d period of skeletal unloading. Through the study of bone density and muscle strength in the same animal, time-points during recovery from simulated microgravity will be identified when bone is at an elevated risk for fracture. These will occur due to the rapid recovery of muscle strength coupled with a slower recovery of bone, producing a significant mismatch in functional strength of these two tissues. Once the time-point of maximal mismatch is defined, various mechanical and pharmacological interventions will be tested at and around this time-point in attempt to minimize the functional difference of bone and muscle. The outcomes of this research will have high relevance for optimizing the rehabilitation of astronauts upon return to Earth, as well as upon landing on the Martian surface before assuming arduous physical tasks. Further. it will impact significantly on rehabilitation issues common to patients experiencing long periods of limb immobilization or bed rest.

  5. Family-based association analysis of beta(2)-adrenergic receptor polymorphisms in the Childhood Asthma Management Program

    NARCIS (Netherlands)

    Silverman, EK; Kwiatkowski, DJ; Sylvia, JS; Lazarus, R; Drazen, JM; Lange, C; Laird, NM; Weiss, ST

    2003-01-01

    Background: beta(2)-Adrenergic receptor (B2AR) polymorphisms have been associated with a variety of asthma-related phenotypes, but association results have been inconsistent across different studies. Objective: We sought to apply family-based association methods to individual single nucleotide polym

  6. NASA Human Research Program Space Radiation Program Element

    Science.gov (United States)

    Chappell, Lori; Huff, Janice; Patel, Janapriya; Wang, Minli; Hu, Shaowwen; Kidane, Yared; Myung-Hee, Kim; Li, Yongfeng; Nounu, Hatem; Plante, Ianik; Ponomarev, Artem; Hada, Megumi

    2013-01-01

    The goal of the NASA Human Research Program's Space Radiation Program Element is to ensure that crews can safely live and work in the space radiation environment. Current work is focused on developing the knowledge base and tools required for accurate assessment of health risks resulting from space radiation exposure including cancer and circulatory and central nervous system diseases, as well as acute risks from solar particle events. Division of Space Life Sciences (DSLS) Space Radiation Team scientists work at multiple levels to advance this goal, with major projects in biological risk research; epidemiology; and physical, biophysical, and biological modeling.

  7. Program of research 1988-89

    International Nuclear Information System (INIS)

    From 1 July 1988, the research activities of ANSTO have reorganised into five programs: advanced materials; applications of nuclear physics; environmental science; applications of radioisotopes and radiation; biomedicine and health. This structure not only groups the main research activities but also identifies the underpinning of ANSTO's commercial activities. This document describes the projects to be undertaken in the 1988-89 financial year. Each project in a particular program area is defined in terms of background, objective, recent work and achievements, work planned, resources and the project manager is identified. Research is also undertaken in areas of the operational activities of the organisation and these also are detailed

  8. Professional Practices in Undergraduate Research Programs.

    Science.gov (United States)

    Seeling, Joni M; Choudhary, Madhusudan

    2016-05-01

    The undergraduate research experience (URE) is an important avenue within a college trajectory in which students enhance their critical thinking, learn about the scientific process, and develop the knowledge and values that will guide their future scientific and professional careers. Individual institutions, programs, departments, and faculty administer undergraduate research differently, but each should adhere to a common set of guidelines which govern the research mentoring process. Adherence to standard practices will enhance the research experience for both students and mentors. This article examines standards and guidelines for professional practices involving undergraduate research and scholarship, and will discuss lapses and limitations that students and faculty frequently confront. The growth, support, and proper management of undergraduate research programs (URPs) at primarily undergraduate institutions (PUIs) is important for maintaining a talented pool of young scientists, as students benefit greatly from direct interactions with faculty mentors that predominate at PUIs.

  9. Professional Practices in Undergraduate Research Programs

    Directory of Open Access Journals (Sweden)

    Joni M. Seeling

    2016-05-01

    Full Text Available The undergraduate research experience (URE is an important avenue within a college trajectory in which students enhance their critical thinking, learn about the scientific process, and develop the knowledge and values that will guide their future scientific and professional careers. Individual institutions, programs, departments, and faculty administer undergraduate research differently, but each should adhere to a common set of guidelines which govern the research mentoring process. Adherence to standard practices will enhance the research experience for both students and mentors. This article examines standards and guidelines for professional practices involving undergraduate research and scholarship, and will discuss lapses and limitations that students and faculty frequently confront. The growth, support, and proper management of undergraduate research programs (URPs at primarily undergraduate institutions (PUIs is important for maintaining a talented pool of young scientists, as students benefit greatly from direct interactions with faculty mentors that predominate at PUIs.

  10. Professional Practices in Undergraduate Research Programs.

    Science.gov (United States)

    Seeling, Joni M; Choudhary, Madhusudan

    2016-05-01

    The undergraduate research experience (URE) is an important avenue within a college trajectory in which students enhance their critical thinking, learn about the scientific process, and develop the knowledge and values that will guide their future scientific and professional careers. Individual institutions, programs, departments, and faculty administer undergraduate research differently, but each should adhere to a common set of guidelines which govern the research mentoring process. Adherence to standard practices will enhance the research experience for both students and mentors. This article examines standards and guidelines for professional practices involving undergraduate research and scholarship, and will discuss lapses and limitations that students and faculty frequently confront. The growth, support, and proper management of undergraduate research programs (URPs) at primarily undergraduate institutions (PUIs) is important for maintaining a talented pool of young scientists, as students benefit greatly from direct interactions with faculty mentors that predominate at PUIs. PMID:27158305

  11. Natural and accelerated bioremediation research program plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    This draft plan describes a ten-year program to develop the scientific understanding needed to harness and develop natural and enhanced biogeochemical processes to bioremediate contaminated soils, sediments and groundwater at DOE facilities. The Office of Health and Environmental Research (OHER) developed this program plan, with advice and assistance from DOE`s Office of Environmental Management (EM). The program builds on OHER`s tradition of sponsoring fundamental research in the life and environmental sciences and was motivated by OHER`s and Office of Energy Research`s (OER`s) commitment to supporting DOE`s environmental management mission and the belief that bioremediation is an important part of the solution to DOE`s environmental problems.

  12. Minority International Research Training Program: Global Collaboration in Nursing Research.

    Science.gov (United States)

    McElmurry, Beverly J.; Misner, Susan J.; Buseh, Aaron G.

    2003-01-01

    The Minority International Research Training Program pairs minority nursing students with faculty mentors at international sites for short-term research. A total of 26 undergraduate, 22 graduate, and 6 postdoctoral students have participated. Challenges include recruitment, orientation, and preparation of students; identification and preparation…

  13. ANSTO - program of research 1991-1992

    International Nuclear Information System (INIS)

    The direction and priorities of the Australian Nuclear Science and Technology Organisation (ANSTO) research program are outlined. During the period under review. Many of the initiatives of previous years come to fruition, adding significant strength and dimension to the Organisation's research capabilities. The advent of Australian Supercomputing Technology, a joint venture between Fujitsu Australia and ANSTO, will enable the grand challenges of computational science to underpin Ansto research generally but specifically in environmental science. The development of the accelerator mass spectrometry facilities on the tandem accelerator supported new initiatives in environmental research and management. The National Medical Cyclotron opens a new era in radiopharmaceutical research and development. Finally, the recently commissioned hot isostatic press provides a unique national resource for the development of new ceramics and their applications. The direction and priorities of Ansto's research program are determined through a combination of external and internal review. The Program Advisory Committees provide external evaluation against national objectives. New Committees have been formed and membership reflects the national and international nature of the ANSTO research programs. ills

  14. Animal models of asthma

    OpenAIRE

    Akkoç, Tunç

    2014-01-01

    ABSTRACT: Allergic disease such as asthma, rhinitis, and eczema are increasing prevelanceand affect up to 15% of population in Westernized countries. Among them, asthma is achronic inflammatory disease of airways and the underlying physiological and immunologicalprocesses are not fully understood. Mouse models of asthma dupicates many featuresof human asthma, including airway hyperreactivity, andairway inflammation. Therefore, relevantmodels for asthma are important to understand the mechanis...

  15. Base Program on Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    Western Research Institute

    2008-06-30

    The main objective of the Base Research Program was to conduct both fundamental and applied research that will assist industry in developing, deploying, and commercializing efficient, nonpolluting fossil energy technologies that can compete effectively in meeting the energy requirements of the Nation. In that regard, tasks proposed under the WRI research areas were aligned with DOE objectives of secure and reliable energy; clean power generation; development of hydrogen resources; energy efficiency and development of innovative fuels from low and no-cost sources. The goal of the Base Research Program was to develop innovative technology solutions that will: (1) Increase the production of United States energy resources--coal, natural gas, oil, and renewable energy resources; (2) Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; (3) Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and (4) Minimize environmental impacts of energy production and utilization. This report summarizes the accomplishments of the overall Base Program. This document represents a stand-alone Final Report for the entire Program. It should be noted that an interim report describing the Program achievements was prepared in 2003 covering the progress made under various tasks completed during the first five years of this Program.

  16. Thunderstorm asthma.

    Science.gov (United States)

    2014-10-01

    AN ASSOCIATION between asthma and thunderstorms based on retrospective data has been noted in several papers. This study, however, draws on almost-real-time, anonymised attendance data from 35 emergency departments (EDs) in the UK, and lightning-strike plots from the Met Office. PMID:25270814

  17. [Severe asthma].

    Science.gov (United States)

    González, Claudio D

    2016-01-01

    The objectives of this work were to investigate the frequency of severe asthma (SA) according to WHO definition and to compare SA patients' characteristics with those of non-severe asthma (NSA); secondly, to investigate the level of control reached throughout a period of regular treatment. Between 1-1-2005 and 12-31-2014, 471 medical records from patients with bronchial asthma assisted in Buenos Aires City were analyzed. SA frequency was 40.1% (189/471), being significantly higher among patients from the public health system (47.7%, 108/226 vs. 33%, 81/245, p = 0.001). SA patients were older than NSA ones (51.3 ± 17.4 vs. 42.6 ± 17.1 years, p = 0.000), presented longer time since onset of the disease (median 30 vs. 20 years, p = 0.000), lower educational levels (secondary level or higher 41.7% vs. 58.1%, p = 0.000), lower frequency of rhinitis (47% vs. 60.6%, p = 0.004), more severe levels of airway obstruction (FEV% 50.2 ± 13.7 vs. 77.7 ± 12.4, p = 0.000), more frequent antecedents of Near Fatal Asthma (11.1% vs. 2.8%, p = 0.000), higher levels of serum IgE (median of 410 vs. 279 UI/l, p = 0.01) and higher demand of systemic steroids requirements and hospitalizations (68.7% vs. 50.7%, p = 0.000 and 37.5% vs. 15.9%, p = 0.000, respectively). A 30.6% of SA patients (58/189) reached a follow-up period of 12 months, 13 (22.5%) of whom reached the controlled asthma level. The frequency of SA found seems to be considerable. Multicenter studies to investigate the levels of control reached by SA patients with access to proper treatment are recommended.

  18. Teacher Research Programs = Increased Student Achievement

    Science.gov (United States)

    Dubner, J.

    2011-12-01

    Columbia University's Summer Research Program for Science Teachers (SRP), founded in 1990, is one of the largest, best known university professional development programs for science teachers in the U.S. For eight weeks in each of two consecutive summers, teachers participate as a member of a research team, led by a member of Columbia University's research faculty. In addition to the laboratory experience, all teachers meet weekly during the summer for a series of pedagogical activities to assist them in transferring the experience to their classrooms. The primary goal of the program is to provide K-12 science teachers with opportunities to work at the cutting edge of science and engineering, and thus to revitalize their teaching and help them to appreciate the use of inquiry-based methods in their classroom instruction. The secondary goals of the program are to give the pre-college teacher the ability to guide their students toward careers in science and engineering, to develop new teaching strategies, and to foster long-term scholarly collaborations. The last is especially important as it leads to a model of the teacher as active in science yet committed to the pre-college classroom. Since its inception, SRP has focused on an objective assessment of the program's impact on attitudes and instructional practices of participating teachers, on the performance of these teachers in their mentors' laboratories, and most importantly, on the impact of their participation in the program has on student interest and performance in science. Our research resulted in a paper published in the journal Science. SRP also facilitates a multi-site survey-based evaluation of other teacher research programs around the country. The author will present the findings of both studies.

  19. Assessment of asthma control using asthma control test in chest clinics in Cameroon: a cross-sectional study

    Science.gov (United States)

    Hugo, Mbatchou Ngahane Bertrand; Walter, Pefura-Yone Eric; Maïmouna, Mama; Malea, Nganda Motto; Ubald, Olinga; Adeline, Wandji; Bruno, Tengang; Emmanuel, Nyankiyé; Emmanuel, Afane Ze; Christopher, Kuaban

    2016-01-01

    Introduction The goal of asthma treatment is to obtain and maintain a good control of symptoms. Investigating factors associated with inadequately control asthma could help in strategies to improve asthma control. This study aimed to determine the prevalence and factors associated with inadequately controlled asthma in asthma patients under chest specialist care. Methods A cross-sectional study was conducted from November 2012 to May 2013. Physician-diagnosed asthma patients aged 12 years and above were included. A questionnaire was used to collect demographic data, comorbidities, and medical history of asthma. Asthma control was assessed using the Asthma Control Test (ACT), with a score less than 20 for inadequately controlled asthma and a score greater or equal to 20 for controlled asthma. A multivariate analysis was used to identify factors associated with inadequately controlled asthma. Results Overall, 243 patients were included in this study. Asthma was controlled in 141 patients (58%) and inadequately controlled in 102 (42%). The mean duration of asthma was 8 years with an interquartile range of 4 and 18 years. Forty-three participants (17.7%) were not under any controller medication while the mean ACT score was 19.3 ± 4.6. Independent associations were found between inadequately controlled asthma and female gender (OR 1.91; 95% CI 1.06-3.47) and obesity (OR 1.81; 1.01-3.27). Conclusion Asthma remains poorly controlled in a large proportion of asthma patients under specialist care in Cameroon. Educational programs for asthma patients targeting women and based on weight loss for obese patients may help in improving the control of asthma. PMID:27217894

  20. Collaborative applied research programs at AITF

    Energy Technology Data Exchange (ETDEWEB)

    Chow, Ross [Alberta Innovates Technology Futures (Canada)

    2011-07-01

    Alberta Innovates Technology Futures (AITF) is a 600 employee company created in 2010 and owned by the Alberta government; offices are located in Edmonton, Devon, Vegreville and Calgary. The purpose of this document is to present the services provided by AITF. The company provides technical support and advisory services as well as commercialization support, they provide the link between the concept stage and the commercialization stage. AITF proposes collaborative programs which can be consortia made up of a series of projects on general industry issues or joint industry projects which focus on a specific issue. During this presentation, a joint industry project, the fuels and lubricants exchange program, was presented along with several consortia such as the carbonate research program, the materials and reliability in oil sands program, and the AACI program. This presentation highlighted the work carried out by AITF to meet the needs of their clients.

  1. Maryland controlled fusion research program. Volume I

    International Nuclear Information System (INIS)

    This renewal proposal describes the University of Maryland research program on Magnetic Fusion Energy for a three-year period beginning January 1, 1986. This program consists of five tasks: (I) Plasma Theory; (II) Electron Cyclotron Emission Diagnostics for Mirror Machines; (III) Electron Cyclotron Emission Diagnostics on TFTR; (IV) Atomic Physics; and (V) Magnetic Field Measurement by Ion Beams. The four separate tasks of continuing research (Tasks I to IV) and the new experimental task (Task V) are described in detail. The task descriptions contain estimated budgets for CY 86, 87, and 88

  2. Overview of NRC PRA research program

    Energy Technology Data Exchange (ETDEWEB)

    Cunningham, M.A.; Drouin, M.T.; Ramey-Smith, A.M.; VanderMolen, M.T. [Pacific Northwest National Lab., Richland, WA (United States)

    1997-02-01

    The NRC`s research program in probabilistic risk analysis includes a set of closely-related elements, from basic research to regulatory applications. The elements of this program are as follows: (1) Development and demonstration of methods and advanced models and tools for use by the NRC staff and others performing risk assessments; (2) Support to agency staff on risk analysis and statistics issues; (3) Reviews of risk assessments submitted by licensees in support of regulatory applications, including the IPEs and IPEEEs. Each of these elements is discussed in the paper, providing highlights of work within an element, and, where appropriate, describing important support and feedback mechanisms among elements.

  3. Environmental Research Program. 1994 annual report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, N.J.

    1995-04-01

    The objective of the Environmental Research Program is to enhance the understanding of, and mitigate the effects of pollutants on health, ecological systems, global and regional climate, and air quality. The program is multi-disciplinary and includes fundamental research and development in efficient and environmentally-benign combustion, pollutant abatement and destruction, and novel methods of detection and analysis of criteria and non-criteria pollutants. This diverse group conducts investigations in combustion, atmospheric and marine processes, flue-gas chemistry, and ecological systems.

  4. Impact of Physician Asthma Care Education on Patient Outcomes

    Science.gov (United States)

    Cabana, Michael D.; Slish, Kathryn K.; Evans, David; Mellins, Robert B.; Brown, Randall W.; Lin, Xihong; Kaciroti, Niko; Clark, Noreen M.

    2014-01-01

    Objective: We evaluated the effectiveness of a continuing medical education program, Physician Asthma Care Education, in improving pediatricians' asthma therapeutic and communication skills and patients' health care utilization for asthma. Methods: We conducted a randomized trial in 10 regions in the United States. Primary care providers…

  5. Test Your Asthma Knowledge

    Science.gov (United States)

    ... Issue Past Issues Special Section Test Your Asthma Knowledge Past Issues / Fall 2007 Table of Contents For ... Asthma: A Chance to Heal / Test Your Asthma Knowledge Fall 2007 Issue: Volume 2 Number 4 Page ...

  6. Asthma triggers (image)

    Science.gov (United States)

    ... things make your asthma worse. These are called asthma "triggers". Avoiding them is your first step toward feeling better. The most common asthma triggers are mold, pets, dust, grasses, pollen, cockroaches, odors ...

  7. Allergies, asthma, and dust

    Science.gov (United States)

    Reactive airway disease - dust; Bronchial asthma - dust; Triggers - dust ... Things that make allergies or asthma worse are called triggers. Dust is a common trigger. When your asthma or allergies become worse due to dust, you are ...

  8. Allergies, asthma, and molds

    Science.gov (United States)

    Reactive airway - mold; Bronchial asthma - mold; Triggers - mold; Allergic rhinitis - pollen ... Things that make allergies or asthma worse are called triggers. Mold is a common trigger. When your asthma or allergies become worse due to mold, you are ...

  9. Asthma in Children

    Science.gov (United States)

    ... have asthma. Nearly 9 million of them are children. Children have smaller airways than adults, which makes asthma especially serious for them. Children with asthma may experience wheezing, coughing, chest tightness, ...

  10. Asthma and Food Allergies

    Science.gov (United States)

    ... Español Text Size Email Print Share Asthma and Food Allergies Page Content Article Body A family history of ... child may develop asthma . Children with asthma and food allergies are at increased risk for anaphylaxis, a severe ...

  11. Asthma Medications and Pregnancy

    Science.gov (United States)

    ... MD Medical Director, Health Initiatives View full profile Asthma and Pregnancy: Asthma Medications We would like to avoid all medicine ... make sure you are using it correctly. Other Asthma Related Medication Treatment Annual influenza vaccine (flu shot) ...

  12. Exercise-Induced Asthma

    Science.gov (United States)

    ... Melon Smoothie Pregnant? Your Baby's Growth Exercise-Induced Asthma KidsHealth > For Parents > Exercise-Induced Asthma Print A ... previous continue Tips for Kids With Exercise-Induced Asthma For the most part, kids with exercise-induced ...

  13. Asthma action plan

    OpenAIRE

    Public Health Agency

    2014-01-01

    This action plans allow each child (or parent/carer) to record his or her asthma treatment to help manage their asthma when they are well, when their symptoms get worse and when they are suffering an asthma attack.

  14. Research of Asthma Treatment in Ancient Literatures%古医籍哮喘治疗探究

    Institute of Scientific and Technical Information of China (English)

    王康乐; 崔健美; 马树祥; 王洪彬

    2015-01-01

    采用数据挖掘的方法对中医大型电子图书《中华医典》中哮喘文献进行系统归纳总结,探寻古医籍中治疗哮喘具有显著疗效的特异性选穴。发现古医籍中选用聚泉、郁中等经外奇穴治疗哮喘,小儿哮喘常选用治马脾风奇穴等,以灸法为主。%This study was aimed to analyze the specific acupoints for treating asthma in ancient literatures.The data mining methods were used to analyze the asthma literatures in Encyclopedia of TCM.The extra acupoints were used for treating asthma such as Juquan, Yuzhong, et al.Mapifeng extra point was used for children with asthma.Moxibustion was often used in ancient literatures.These experience could guide the modern clinical treatment for asthma.

  15. Laboratory Directed Research ampersand Development Program

    International Nuclear Information System (INIS)

    At Brookhaven National Laboratory the Laboratory Directed Research and Development (LDRD) Program is a discretionary research and development tool critical in maintaining the scientific excellence and vitality of the laboratory. It is also a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor in achieving and maintaining staff excellence, and a means to address national needs, within the overall mission of the Department of Energy and Brookhaven National Laboratory. This report summarizes research which was funded by this program during fiscal year 1993. The research fell in a number of broad technical and scientific categories: new directions for energy technologies; global change; radiation therapies and imaging; genetic studies; new directions for the development and utilization of BNL facilities; miscellaneous projects. Two million dollars in funding supported 28 projects which were spread throughout all BNL scientific departments

  16. Internet-based self-management in asthma

    OpenAIRE

    van der Meer, Victor

    2010-01-01

    This thesis describes the role of internet-based support in the delivery of an asthma self management program. First, the compliance and reliability of home lung function monitoring, one of the key features of asthma self-management, was studied and appeared to be high over a 4-week period. Second, we explored intrinsic barriers to current asthma management and revealed possible benefits from internet-based asthma self-management. Participants considered feasible electronic monitoring, easily...

  17. Attentional bias to respiratory- and anxiety-related threat in children with asthma.

    Science.gov (United States)

    Lowther, Helen; Newman, Emily; Sharp, Kirstin; McMurray, Ann

    2016-08-01

    This study investigated attentional biases in children with asthma. The study aimed at testing whether children with asthma are vigilant to asthma and/or anxiety cues. Thirty-six children (18 with asthma and 18 healthy controls) aged 9-12 completed a computerised dot probe task designed to measure attentional bias to three different categories of words: asthma, anxiety symptom and general negative emotion. Main caregiver anxiety was also assessed, as was frequency of inhaler use for those with asthma. Children with asthma showed an attentional bias towards asthma words but not anxiety or general negative emotion words. Children without asthma showed no significant attentional biases to any word categories. Caregiver anxiety was correlated with asthma word attentional bias in the asthma group. The findings indicate that attentional bias is present in children with asthma. Further research is required to ascertain if this exacerbates or maintains health-related problems. PMID:25966340

  18. Research and development program, fiscal year 1974

    Energy Technology Data Exchange (ETDEWEB)

    1972-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for Fiscal Year 1974 is conducted within the scope of the following categories: Effects of Radiation of Living Organisms; Molecular and Cellular Radiobiology; Land and Fresh Water Environmental Sciences; Radiological and Health Physics and Instrumentation; and Nuclear Medical Research. (ACR)

  19. Crime Laboratory Proficiency Testing Research Program.

    Science.gov (United States)

    Peterson, Joseph L.; And Others

    A three-year research effort was conducted to design a crime laboratory proficiency testing program encompassing the United States. The objectives were to: (1) determine the feasibility of preparation and distribution of different classes of physical evidence; (2) assess the accuracy of criminalistics laboratories in the processing of selected…

  20. The Dental Services Research Scholars Program.

    Science.gov (United States)

    Keenan, Terrance

    1983-01-01

    A foundation program to bring research on health services and policy issues into the domain of clinical scholarship is described. The principal approach is to train young clinicians for academic careers with major responsibilities in health studies at university health sciences centers. (MSE)

  1. ANSTO program of research 1989-1990

    International Nuclear Information System (INIS)

    The 1989-1990 Program of Research of the Australian Nuclear Science and Technology Organization identifies the diversity of the organisation's current activities and the role of nuclear science and technology in achieving national goals. Major program areas continue to be biomedicine and health, advanced materials, applications of nuclear physics, environmental science, isotope technology and nuclear technology. Each project in a particular program area is defined in terms of background, objectives recent work and achievements, work planned and resources. External advisory committees which provide advice on research priorities, are viewed as a fundamental part of the ongoing evaluation process of the organization activities in response to changing priorities in industry, government and the community it serves

  2. Program of research - 1990-1991

    International Nuclear Information System (INIS)

    The 1990-1991 Program of Research reflects the fundamental changes within the Australian Nuclear Science and Technology Organization (ANSTO) over the past three years as it has oriented itself towards being a more commercially driven organization, an organization responding to market demands and pressures. From July 1, 1990 several key projects have been linked together in the new Industrial Technology Program. The Program encompasses projects that have real potential to earn revenue for ANSTO and make measurable improvements in efficiency and productivity for Australian companies. The Isotope Technology project is researching and transferring to industry radioisotope technology for tracing the effectiveness of plant processes, the movement of materials within blast furnaces and leakages and outages in plant pipework. The two important newcomers are the Quality Technology Centre and the Safety and Reliability group. Details about project leaders, project titles and objectives are provided. ills

  3. Safety research programs sponsored by Office of Nuclear Regulatory Research

    International Nuclear Information System (INIS)

    This progress report describes current activities and technical progress in the programs at Brookhaven National Laboratory sponsored by the Division of Regulatory Applications, Division of Engineering, Division of Safety Issue Resolution, and Division of Systems Research of the US Nuclear Regulatory Commission, Office of Nuclear Regulatory Research following the reorganization in July 1988. The previous reports have covered the period October 1, 1976 through September 30, 1988

  4. A research program in empirical computer science

    Science.gov (United States)

    Knight, J. C.

    1991-01-01

    During the grant reporting period our primary activities have been to begin preparation for the establishment of a research program in experimental computer science. The focus of research in this program will be safety-critical systems. Many questions that arise in the effort to improve software dependability can only be addressed empirically. For example, there is no way to predict the performance of the various proposed approaches to building fault-tolerant software. Performance models, though valuable, are parameterized and cannot be used to make quantitative predictions without experimental determination of underlying distributions. In the past, experimentation has been able to shed some light on the practical benefits and limitations of software fault tolerance. It is common, also, for experimentation to reveal new questions or new aspects of problems that were previously unknown. A good example is the Consistent Comparison Problem that was revealed by experimentation and subsequently studied in depth. The result was a clear understanding of a previously unknown problem with software fault tolerance. The purpose of a research program in empirical computer science is to perform controlled experiments in the area of real-time, embedded control systems. The goal of the various experiments will be to determine better approaches to the construction of the software for computing systems that have to be relied upon. As such it will validate research concepts from other sources, provide new research results, and facilitate the transition of research results from concepts to practical procedures that can be applied with low risk to NASA flight projects. The target of experimentation will be the production software development activities undertaken by any organization prepared to contribute to the research program. Experimental goals, procedures, data analysis and result reporting will be performed for the most part by the University of Virginia.

  5. Nuclear Plant Aging Research (NPAR) program plan

    International Nuclear Information System (INIS)

    A comprehensive Nuclear Plant Aging Research (NPAR) Program was implemented by the US NRC office of Nuclear Regulatory Research in 1985 to identify and resolve technical safety issues related to the aging of systems, structures, and components in operating nuclear power plants. This is Revision 2 to the Nuclear Plant Aging Research Program Plant. This planes defines the goals of the program the current status of research, and summarizes utilization of the research results in the regulatory process. The plan also describes major milestones and schedules for coordinating research within the agency and with organizations and institutions outside the agency, both domestic and foreign. Currently the NPAR Program comprises seven major areas: (1) hardware-oriented engineering research involving components and structures; (2) system-oriented aging interaction studies; (3) development of technical bases for license renewal rulemaking; (4) determining risk significance of aging phenomena; (5) development of technical bases for resolving generic safety issues; (6) recommendations for field inspection and maintenance addressing aging concerns; (7) and residual lifetime evaluations of major LWR components and structures. The NPAR technical database comprises approximately 100 NUREG/CR reports by June 1991, plus numerous published papers and proceedings that offer regulators and industry important insights to aging characteristics and aging management of safety-related equipment. Regulatory applications include revisions to and development of regulatory guides and technical specifications; support to resolve generic safety issues; development of codes and standards; evaluation of diagnostic techniques; (e.g., for cables and valves); and technical support for development of the license renewal rule. 80 refs., 25 figs., 10 tabs

  6. Animal models of asthma

    OpenAIRE

    Bates, Jason H.T.; Rincon, Mercedes; Irvin, Charles G.

    2009-01-01

    Studies in animal models form the basis for much of our current understanding of the pathophysiology of asthma, and are central to the preclinical development of drug therapies. No animal model completely recapitulates all features of the human disease, however. Research has focused primarily on ways to generate allergic inflammation by sensitizing and challenging animals with a variety of foreign proteins, leading to an increased understanding of the immunological factors that mediate the in...

  7. Extending the JOVE Program through undergraduate research

    Science.gov (United States)

    Lebo, George R.

    1996-01-01

    The JOVE program was initiated in 1988 to develop NASA-related research capabilities in colleges and universities which had had little or no previous experience with NASA. Any institution which was not currently funded at more than $100 K annually by NASA was eligible. In an open competition six universities were selected for participation in the first year. NASA supplied funds, access to its facilities and data, collaboration with its researchers and a hookup to the internet. In return the university was expected to match NASA's investment by giving its participating faculty members time off of their teaching schedules to perform research during the school year, by waiving it overhead charge and by putting up real funds to match those supplied by NASA. Each school was eligible for three years after which they were expected to seek funds from other sources. Over the span of the program more than 100 colleges and universities have participated. Fifteen have finished their eligiblity. Since one of the strong components of the program was the direct involvement of undergraduate students in active research, it was decided to develop a follow-on program which would provide stipends to undergraduate students at the institutions who had used up their JOVE eligiblity. NASA's desire to transfer its technologies to the private sector now permeates all of its programs. Therefore a Partnering Venture (PAVE) program is now being discussed in which JOVE-like rules will be applied to small companies which do not now do much business with NASA. The JOVE, PAVE, and other summer activities of the author are told here.

  8. Coordinated Research Project: Relationship between recurrent lower respiratory tract infection, bronchial asthma and gastroesophageal reflux in children

    International Nuclear Information System (INIS)

    Gastroesophageal reflux may cause or contribute to different respiratory problems such as bronchial asthma (BA), recurrent lower respiratory tract infection (rLRTI), among others. There is no clear cut explanation of mechanisms responsible for the respiratory symptoms in children with recurrent GER, and how beneficial GER treatment could be in the management of this children. The aim of this prospective coordinate research project was to evaluated the presence of GER, esophageal transit (ET) abnormalities and lung aspiration (LA) in children with recurrent respiratory symptoms. So far we had evaluated 309 children; 173 boys and 136 girls, between 15 days and 15 years old of age. Under standard and protocolized procedures all children underwent gastroesophageal scintigraphic study. Esophageal transit scintigraphy (ETS) was performed in 127 and LA scintigraphy in 205. The scintigraphic study was positive for GER in 160/309 (51.8%) of the total group. We found an abnormal ETS in 13.4% and a LA scintigraphy positive for aspiration of gastric content in 3.9% of the studied patients. According to clinical features, 75% of asthmatic children with persistent symptoms had GER and 30.7% of children with rLRTI. Follow-up studies were performed in 85 children after treatment of GER and there was a normalization of the scintigraphic study, associated with clinical improvement in 69.4% of them. These results show that GER prevalence in children with BA and rLRTI is higher than the reported normal prevalence in infancy, specially in the group of asthmatic patients. In our group, we do not find a significant presence of ET abnormalities neither LA of gastric content. The diagnosis and treatment of GER is mandatory in children with rLRTI or persistent BA. In asthmatic patients the recognition of gastric abnormalities is highly relevant for therapeutic problems when GER is in a sub-clinical stage

  9. NRC hydrogen behavior and mitigation research program

    International Nuclear Information System (INIS)

    To address hydrogen-related issues, the Office of Nuclear Regulatory Research (Divisions of Accident Evaluation and Engineering Technology) has initiated a comprehensive research program whose objective is to quantify the threat posed by hydrogen released during severe reactor accidents, and to generate information, procedures and concepts which will prevent or mitigate that threat. The products of this research program will include: 1) assessment of the threat for several classes of reactors and containment designs; 2) assessment of the adequacy of existing safety systems and mitigation strategies; 3) identification and concept demonstration of improved mitigation and detection systems; 4) publication of manuals and reports on: evaluation of the state-of-the-art; phenomena important to threat assessment; operator strategies and training; and reactor safety issues; 5) development and applications of computer codes for addressing the generation, transport, combustion and mitigation of hydrogen during hypothetical reactor accidents

  10. Comparison of early-, late-, and non-participants in a school-based asthma management program for urban high school students

    Directory of Open Access Journals (Sweden)

    Alexander Gwen

    2011-06-01

    Full Text Available Abstract Background To assess bias and generalizability of results in randomized controlled trials (RCT, investigators compare participants to non-participants or early- to late-participants. Comparisons can also inform the recruitment approach, especially when working with challenging populations, such as urban adolescents. In this paper, we describe characteristics by participant status of urban teens eligible to participate in a RCT of a school-based, web-based asthma management program. Methods The denominator for this analysis was all students found to be eligible to participate in the RCT. Data were analyzed for participants and non-participants of the RCT, as well as for students that enrolled during the initially scheduled recruitment period (early-participants and persons that delayed enrollment until the following fall when recruitment was re-opened to increase sample size (late-participants. Full Time Equivalents (FTEs of staff associated with recruitment were estimated. Results Of 1668 teens eligible for the RCT, 386 enrolled early, and 36 enrolled late, leaving 1246 non-participants. Participants were younger (p Conclusions Recruitment messages attracted youth with moderate-to-severe asthma, but extending enrollment was costly, resulting in potentially less motivated, and certainly less compliant, participants. Investigators must balance internal versus external validity in the decision to extend recruitment. Gains in sample size and external validity may be offset by the cost of additional staff time and the threat to internal validity caused by lower participant follow-up. Trial Registration ClinicalTrials.gov: NCT00201058

  11. DOE (Department of Energy) Epidemiologic Research Program

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    The objective of the Department of Energy (DOE) Epidemiologic Research Program is to determine the human health effects resulting from the generation and use of energy, and of the operation of DOE facilities. The program is divided into seven general areas of activity; the Radiation Effects Research Foundation (RERF) which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki, mortality and morbidity studies of DOE workers, studies on internally deposited alpha emitters, medical/histologic studies, studies on the aspects of radiation damage, community health surveillance studies, and the development of computational techniques and of databases to make the results as widely useful as possible. Excluding the extensive literature from the RERF, the program has produced 340 publications in scientific journals, contributing significantly to improving the understanding of the health effects of ionizing radiation exposure. In addition, a large number of public presentations were made and are documented elsewhere in published proceedings or in books. The purpose of this bibliography is to present a guide to the research results obtained by scientists supported by the program. The bibliography, which includes doctoral theses, is classified by laboratory and by year and also summarizes the results from individual authors by journal.

  12. DOE [Department of Energy] Epidemiologic Research Program

    International Nuclear Information System (INIS)

    The objective of the Department of Energy (DOE) Epidemiologic Research Program is to determine the human health effects resulting from the generation and use of energy, and of the operation of DOE facilities. The program is divided into seven general areas of activity; the Radiation Effects Research Foundation (RERF) which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki, mortality and morbidity studies of DOE workers, studies on internally deposited alpha emitters, medical/histologic studies, studies on the aspects of radiation damage, community health surveillance studies, and the development of computational techniques and of databases to make the results as widely useful as possible. Excluding the extensive literature from the RERF, the program has produced 340 publications in scientific journals, contributing significantly to improving the understanding of the health effects of ionizing radiation exposure. In addition, a large number of public presentations were made and are documented elsewhere in published proceedings or in books. The purpose of this bibliography is to present a guide to the research results obtained by scientists supported by the program. The bibliography, which includes doctoral theses, is classified by laboratory and by year and also summarizes the results from individual authors by journal

  13. Genetics of asthma: a molecular biologist perspective

    Directory of Open Access Journals (Sweden)

    Ghosh Balaram

    2009-05-01

    Full Text Available Abstract Asthma belongs to the category of classical allergic diseases which generally arise due to IgE mediated hypersensitivity to environmental triggers. Since its prevalence is very high in developed or urbanized societies it is also referred to as "disease of civilizations". Due to its increased prevalence among related individuals, it was understood quite long back that it is a genetic disorder. Well designed epidemiological studies reinforced these views. The advent of modern biological technology saw further refinements in our understanding of genetics of asthma and led to the realization that asthma is not a disorder with simple Mendelian mode of inheritance but a multifactorial disorder of the airways brought about by complex interaction between genetic and environmental factors. Current asthma research has witnessed evidences that are compelling researchers to redefine asthma altogether. Although no consensus exists among workers regarding its definition, it seems obvious that several pathologies, all affecting the airways, have been clubbed into one common category called asthma. Needless to say, genetic studies have led from the front in bringing about these transformations. Genomics, molecular biology, immunology and other interrelated disciplines have unearthed data that has changed the way we think about asthma now. In this review, we center our discussions on genetic basis of asthma; the molecular mechanisms involved in its pathogenesis. Taking cue from the existing data we would briefly ponder over the future directions that should improve our understanding of asthma pathogenesis.

  14. Human Research Program Integrated Research Plan. Revision C

    Science.gov (United States)

    Steinberg, Susan

    2011-01-01

    Crew health and performance are critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes (1) HRP's approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and (2) the method of integration for risk mitigation. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

  15. Small business innovation research: Program solicitation

    Science.gov (United States)

    1989-01-01

    This, the seventh annual SBIR solicitation by NASA, describes the program, identifies eligibility requirements, outlines the required proposal format and content, states proposal preparation and submission requirements, describes the proposal evaluation and award selection process, and provides other information to assist those interested in participating in NASA's SBIR program. It also identifies the Technical Topics and Subtopics in which SBIR Phase 1 proposals are solicited in 1989. These Topics and Subtopics cover a broad range of current NASA interests, but do not necessarily include all areas in which NASA plans or currently conducts research. High-risk high pay-off innovations are desired.

  16. Experiencia de un Programa de Control de Asma Bronquial en Puerto Montt, Chile Report of a bronchial asthma control program in Puerto Montt, Chile

    Directory of Open Access Journals (Sweden)

    MAURICIO RIQUELME O

    2006-06-01

    Full Text Available El asma es una patología de comportamiento clínico variable y generalmente sub tratada. Material y métodos: En Puerto Montt se implementó un Programa de Control de Asma Bronquial integrado con el nivel primario de atención, que clasifica los pacientes usando criterios de gravedad. Se analizó la evolución de 135 asmáticos en 6 controles trimestrales cubriendo 18 meses de seguimiento. Resultados: Hubo disminución progresiva y significativa de los niveles de severidad, de síntomas diurnos y nocturnos, aumento de la capacidad de ejercicio (p = 0,001 y del flujo espiratorio máximo (PEF (0,0001. Se identificó un subgrupo de asmáticos graves (12,5% responsables de la gran mayoría de las consultas en urgencia y de las hospitalizaciones. Conclusiones: El manejo organizado de los pacientes asmáticos permitió obtener ventajas clínicas objetivablesAsthma is a disease with a variable clinical behaviour and usually insufficiently treated and managed. Methods: An Asthma Control Program was implemented in Puerto Montt, Chile, with the out patient participation of the primary medical care system. This Program classifies the asthmatic patients by using preestablished criteria of severity. We analyzed the evolution of 135 patients through six quarterly medical controls covering 18 months of follow up. Results: Patients diminished progressively and significantly their severity levels and their daily and nocturnal symptoms. Besides a significant increase of physical capacity (p = 0.001 and peak expiratory flow (PEF (p = 0.0001 was observed. A series of severe asthmatic patients (12.5% was identified. This group concentrated most of the emergency consultations and hospitalizations. Conclusions: An organized management of asthmatic patients has allowed us to show objectively clinical improvements in these patients after entering to this program

  17. Poor communication may impair optimal asthma care : a qualitative study

    NARCIS (Netherlands)

    Moffat, Mandy; Cleland, Jennifer; van der Molen, Thys; Price, David

    2007-01-01

    Background. Despite asthma being primarily managed in general practice and primary care, there is little research into the issues and tools which may impact on managing poorly controlled asthma in this setting. Objective. To explore the views of health care professionals (HCPs) towards asthma guidel

  18. Allergic Rhinitis and its Impact on Asthma (ARIA)

    DEFF Research Database (Denmark)

    Bousquet, J; Schünemann, H J; Samolinski, B;

    2012-01-01

    Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has rec...... workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children....

  19. Screening for childhood asthma using an exercise test.

    OpenAIRE

    Jones, A.; Bowen, M

    1994-01-01

    BACKGROUND. Screening for asthma in children in the community could have advantages at a time when prevalence rates of the condition and associated hospital admission rates are rising. AIM. The aim of this study was to assess the usefulness of a standard exercise test as a marker of asthma or potential asthma in children, and to examine the relationship between asthma and other respiratory tract illnesses. METHOD. In 1985 a cross-sectional research study was undertaken in 10 primary schools i...

  20. The research program at SIS/ESR

    International Nuclear Information System (INIS)

    A varied research program is currently in preparation for the expanded facility. Above one hundred experiments have been proposed following a call for proposals about 1 1/2 year ago, and have been reviewed by an international science committee. About half of the proposals were aimed at research in nuclear and nuclear-matter physics. These are discussed in more detail in the present overview. In addition, about 25% of the proposals were in the area of atomic physics, planning to make use of the capability of the new facility to strip even the heaviest ions into the innermost shells, with the additional possibility of subsequent cooling and deceleration. Biological research, utilizing the larger range of ions at elevated energies and thus deeper penetration and also irradiation in atmosphere, represented about 15% of the proposals; the rest was divided among various projects of applied research. (orig./HSI)

  1. Suborbital Science Program: Dryden Flight Research Center

    Science.gov (United States)

    DelFrate, John

    2008-01-01

    This viewgraph presentation reviews the suborbital science program at NASA Dryden Flight Research Center. The Program Objectives are given in various areas: (1) Satellite Calibration and Validation (Cal/val)--Provide methods to perform the cal/val requirements for Earth Observing System satellites; (2) New Sensor Development -- Provide methods to reduce risk for new sensor concepts and algorithm development prior to committing sensors to operations; (3) Process Studies -- Facilitate the acquisition of high spatial/temporal resolution focused measurements that are required to understand small atmospheric and surface structures which generate powerful Earth system effects; and (4) Airborne Networking -- Develop disruption-tolerant networking to enable integrated multiple scale measurements of critical environmental features. Dryden supports the NASA Airborne Science Program and the nation in several elements: ER-2, G-3, DC-8, Ikhana (Predator B) & Global Hawk and Reveal. These are reviewed in detail in the presentation.

  2. Jointly Sponsored Research Program on Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    No, author

    2013-12-31

    Cooperative Agreements, DE-FC26-08NT43293, DOE-WRI Cooperative Research and Development Program for Fossil Energy-Related Resources began in June 2009. The goal of the Program was to develop, commercialize, and deploy technologies of value to the nation’s fossil and renewable energy industries. To ensure relevancy and early commercialization, the involvement of an industrial partner was encouraged. In that regard, the Program stipulated that a minimum of 20% cost share be achieved in a fiscal year. This allowed WRI to carry a diverse portfolio of technologies and projects at various development technology readiness levels. Depending upon the maturity of the research concept and technology, cost share for a given task ranged from none to as high as 67% (two-thirds). Over the course of the Program, a total of twenty six tasks were proposed for DOE approval. Over the period of performance of the Cooperative agreement, WRI has put in place projects utilizing a total of $7,089,581 in USDOE funds. Against this funding, cosponsors have committed $7,398,476 in private funds to produce a program valued at $14,488,057. Tables 1 and 2 presented at the end of this section is a compilation of the funding for all the tasks conducted under the program. The goal of the Cooperative Research and Development Program for Fossil Energy-Related Resources was to through collaborative research with the industry, develop or assist in the development of innovative technology solutions that will: • Increase the production of United States energy resources – coal, natural gas, oil, and renewable energy resources; • Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; • Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and • Minimize environmental impacts of energy production and utilization. Success of the Program can be measured by

  3. Asthma and obesity

    DEFF Research Database (Denmark)

    Juel, Caroline Trunk-Black; Ali, Zarqa; Nilas, Lisbeth;

    2012-01-01

    Obesity is a major health problem, and obesity is associated with a high incidence of asthma and poor asthma control. The aim of the present paper is to systematically review the current knowledge of the effect on overall asthma control of weight reduction in overweight and obese adults with asthma....

  4. The National Geothermal Energy Research Program

    Science.gov (United States)

    Green, R. J.

    1974-01-01

    The continuous demand for energy and the concern for shortages of conventional energy resources have spurred the nation to consider alternate energy resources, such as geothermal. Although significant growth in the one natural steam field located in the United States has occurred, a major effort is now needed if geothermal energy, in its several forms, is to contribute to the nation's energy supplies. From the early informal efforts of an Interagency Panel for Geothermal Energy Research, a 5-year Federal program has evolved whose objective is the rapid development of a commercial industry for the utilization of geothermal resources for electric power production and other products. The Federal program seeks to evaluate the realistic potential of geothermal energy, to support the necessary research and technology needed to demonstrate the economic and environmental feasibility of the several types of geothermal resources, and to address the legal and institutional problems concerned in the stimulation and regulation of this new industry.

  5. The Nanotoxicology Research Program in NIOSH

    International Nuclear Information System (INIS)

    The National Institute for Occupational Safety and Health through its Nanotechnology Research Center has developed a Strategic Plan for Nanotechnology Safety and Health Research. This Strategic Plan identified knowledge gaps and critical issues, which must be addressed to protect the health and safety of workers producing nanoparticles as well as those incorporating nanoparticles into commercial products or using nanomaterials in novel applications. This manuscript lists the projects that comprise the Nanotoxicology Program in NIOSH and provides a brief description of the goals and accomplishments of these projects.

  6. The Nanotoxicology Research Program in NIOSH

    Energy Technology Data Exchange (ETDEWEB)

    Castranova, Vincent, E-mail: vic1@cdc.go [National Institute for Occupational Safety and Health, Health Effects Laboratory Division (United States)

    2009-01-15

    The National Institute for Occupational Safety and Health through its Nanotechnology Research Center has developed a Strategic Plan for Nanotechnology Safety and Health Research. This Strategic Plan identified knowledge gaps and critical issues, which must be addressed to protect the health and safety of workers producing nanoparticles as well as those incorporating nanoparticles into commercial products or using nanomaterials in novel applications. This manuscript lists the projects that comprise the Nanotoxicology Program in NIOSH and provides a brief description of the goals and accomplishments of these projects.

  7. Sandia combustion research program: Annual report, 1987

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, R.E.; Sanders, B.R.; Ivanetich, C.A. (eds.)

    1988-01-01

    More than a decade ago, in response to a national energy crisis, Sandia proposed to the US Department of Energy a new, ambitious program in combustion research. Our strategy was to apply the rapidly increasing capabilities in lasers and computers to combustion science and technology. Shortly thereafter, the Combustion Research Facility (CRF) was established at Sandia's Livermore location. Designated a ''User Facility,'' the charter of the CRF was to develop and maintain special-purpose resources to support a nationwide initiative--involving US universities, industry, and national laboratories--to improve our understanding and control of combustion. This report includes descriptions of several research projects which have been stimulated by Working Groups and involve the on-site participation of industry scientists. DOE's Industry Technology Fellowship Program has been instrumental in the success of some of the joint efforts. The remainder of this report presents research results of calendar year 1987, separated thematically into nine categories. Refereed journal articles appearing in print during 1987, along with selected other publications, are included at the end of Section 10. In addition to our ''traditional'' research--chemistry, reacting flow, diagnostics, engine combustion, and coal combustion--you will note continued progress in somewhat recent themes: pulse combustion, high temperature materials, and energetic materials, for example. Moreover, we have just started a small, new effort to understand combustion-related issues in the management of toxic and hazardous materials.

  8. Laboratory Directed Research and Development Program

    International Nuclear Information System (INIS)

    This report is compiled from annual reports submitted by principal investigators following the close of fiscal year 1993. This report describes the projects supported and summarizes their accomplishments. The program advances the Laboratory's core competencies, foundations, scientific capability, and permits exploration of exciting new opportunities. Reports are given from the following divisions: Accelerator and Fusion Research, Chemical Sciences, Earth Sciences, Energy and Environment, Engineering, Environment -- Health and Safety, Information and Computing Sciences, Life Sciences, Materials Sciences, Nuclear Science, Physics, and Structural Biology

  9. 76 FR 77505 - Applications for New Awards; Research Fellowships Program

    Science.gov (United States)

    2011-12-13

    ... Applications for New Awards; Research Fellowships Program AGENCY: Office of Special Education and... Education. ACTION: Notice. Overview Information: Research Fellowships Program; Notice inviting applications... seven or more years of research experience in subject areas, methods, or techniques relevant...

  10. Laboratory Directed Research and Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Ogeka, G.J.

    1991-12-01

    Today, new ideas and opportunities, fostering the advancement of technology, are occurring at an ever-increasing rate. It, therefore, seems appropriate that a vehicle be available which fosters the development of these new ideas and technologies, promotes the early exploration and exploitation of creative and innovative concepts, and which develops new fundable'' R D projects and programs. At Brookhaven National Laboratory (BNL), one such method is through its Laboratory Directed Research and Development (LDRD) Program. This discretionary research and development tool is critical in maintaining the scientific excellence and vitality of the Laboratory. Additionally, it is a means to stimulate the scientific community, fostering new science and technology ideas, which is the major factor achieving and maintaining staff excellence, and a means to address national needs, with the overall mission of the Department of Energy (DOE) and the Brookhaven National Laboratory. The Project Summaries with their accomplishments described in this report reflect the above. Aside from leading to new fundable or promising programs and producing especially noteworthy research, they have resulted in numerous publications in various professional and scientific journals, and presentations at meetings and forums.

  11. ASRL core research program 2010 - 2011

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2010-01-15

    This article summarized the core research program of Alberta Sulphur Research Ltd. The high-priority projects are improved liquid sulfur degassing technologies, improved tail gas treatment processes, oxygen consumption in amine systems, formation of hydrogen sulphide (H{sub 2}S) in shale gas reservoirs and during the steam assisted gravity drainage (SAGD) recovery of heavy oil and bitumen, designer hydrocarbon sulfur solvents for sour gas production, determination of the kinetics of H{sub 2}S oxidation in compression systems, H{sub 2}S and sulphur dioxide (SO{sub 2}) solubility in liquid sulfur updating and checking FTIR calibrations, low tonnage sulfur recovery, the effect of BTX on reduction catalysts used in Claus tail gas processing, measurement of acid gas properties at high pressure, catalytic tail gas incineration, and sulfur dust properties. The projects identified as important areas of research are acid gas injection water holding capacity for acid gas mixtures; rate of decomposition of polymeric sulfur; ammonium salt plugging in the Claus Converter Train; re-examination of catalytic partial oxidation for sulfur recovery from low H{sub 2}S content hydrocarbon contaminated acid gas; primary upgrading of oil sands bitumen; prediction of sulfur deposition in sour gas reservoirs; and new extended uses of elemental sulfur. There are two fundamental research programs, which include ongoing research and partial external funding: production of C{sub 3} - C{sub 6} olefins, high octane alkylate, and valuable petrochemicals and computational modeling of catalytic systems. The commercial and specific objectives of each project were described. Two special projects, which aim to take Alberta Sulphur Research Ltd. (ASRL) core research to the commercial demonstration phase, involve injection of SO{sub 2} into disposal reservoirs and above-ground sulfur storage. 1 tab., 22 figs.

  12. Imaging of Asthma.

    Science.gov (United States)

    Richards, John Caleb; Lynch, David; Koelsch, Tilman; Dyer, Debra

    2016-08-01

    Asthma is one of the most common diseases of the lung. Asthma manifests with common, although often subjective and nonspecific, imaging features at radiography and high-resolution computed tomography. The primary role of imaging is not to make a diagnosis of asthma but to identify complications, such as allergic bronchopulmonary aspergillosis, or mimics of asthma, such as hypersensitivity pneumonitis. This article reviews the imaging features of asthma as well as common complications and mimics. PMID:27401624

  13. Advances in asthma pathophysiology: Stepping forward from the maurizio vignola experience

    OpenAIRE

    Maria R. Bonsignore; Mirella Profita; Rosalia Gagliardo; Loredana Riccobono; Giuseppina Chiappara; Elisabetta Pace; Mark Gjomarkaj

    2015-01-01

    Maurizio Vignola was a superb and innovative researcher, who wrote seminal papers on the biology of airway epithelium in asthma. Inflammation and remodelling were the main topics of his research, mostly conducted in biopsy specimens from patients with asthma of variable severity, encompassing the entire spectrum of the disease from mild to severe asthma. His observations contributed to define the biology of asthma as we know it today, and opened the way to the personalised treatment of asthma...

  14. Research and development program, fiscal year 1966

    Energy Technology Data Exchange (ETDEWEB)

    1964-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1966 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Chemical Toxicity; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine program may be summarized as follows: (1) investigation of the effects of ionizing radiation on living organisms and systems of biological significance; (2) investigation of the dynamic aspects of physiological and biochemical processes in man, animals and plants and how these processes are modified by radiation and related pathological states; (3) the assessment and study of the immediate and long term consequences of the operation or detonation of nuclear devices on the fauna, and flora in man's environment and on man; (4) the development of methods of minimizing or preventing the detrimental effects of ionizing radiation; (5) research in, and development of, beneficial uses of ionizing radiation and radioactive substances in medicine and biology; (6) research in the development of new and more efficient radiation detection devices; (7) research, including field studies, as mutually agreed upon by the Commission and the University, in connection with the conduct of weapon tests and biomedical and civil effects experiments at such tests conducted at continental and overseas test sites; and (8) the conduct of training and educational activities in the biological and medical aspects of radiation and related fields.

  15. Heuristic Programming of Educational - Research Activity

    Science.gov (United States)

    Stoev, Alexey

    HEURISTIC PROGRAMMING OF EDUCATIONAL - RESEARCH ACTIVITY OF THE STUDENTS OF ASTRONOMY AT PUBLIC ASTRONOMICAL OBSERVATORIES A.Stoev Yu. Gagarin Public Astronomical Observatory Stara Zagora Bulgaria Seeking for optimal conditions of the students’ investigation skills development is exceptionally actual task in Astronomy school at Public astronomical observatory. The didactic plan of its solving is connected with a realization of the concept of the problematic approach in astronomical education. In addition different means of astronomical educative activity organization are used depending on the didactic task. In some cases they are algorithmic but in others - mainly heuristic. Educational - research skills are defined as skills of scientific method use in the conditions of seeking for educational problem solving the astronomical educational - research task. The influence of the system of heuristic programming didactic means on the process of teaching and the use of system of didactic means for out of the school education on astronomy aimed mainly to this activity rule are analyzed. In conclusion the process of optimization of the didactic conditions for students’ self-organization during the individual or collective completion of the educational - research astronomical tasks at the transition from secondary to high education.

  16. Summer High School Apprenticeship Research Program (SHARP)

    Science.gov (United States)

    1997-01-01

    objectives were consistent with the overall program goals. Modem Technology Systems, Inc., was able to meet the SHARP Apprentices, Coordinators and Mentors during their site visits to Stennis Space Center, Ames Research Center and Dryden Flight Research Center. All three Centers had very efficient programs and adhered to SHARP's general guidelines and procedures. MTSI was able to meet the apprentices from the other Centers via satellite in July during the SHARP Video-Teleconference(ViTS). The ViTS offered the apprentices and the NASA and SHARP Coordinators the opportunity to introduce themselves. The apprentices from each Center presented topical "Cutting Edge Projects". Some of the accomplishments for the 1997 SHARP Program year included: MTSI hiring apprentices from four of the nine NASA Centers, the full utilization of the EDCATS by apprentices and NASA/SHARP Coordinators, the distribution of the SHARP Apprentice College and Scholarship Directory, a reunion with former apprentices from Langley Research Center and the development of a SHARP Recruitment Poster. MTSI developed another exciting newsletter containing graphics and articles submitted by the apprentices and the SHARP Management Team.

  17. Energy Efficient Industrialized Housing Research Program

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    Six area reported progress in the Energy Efficient Industrialized Housing Research Program during FY 1991. As part of Industry Guidance, meetings were held with steering and technical committees in computers, housing design and manufacturing. This task area enables the program to benefit from the expertise of industry representatives and communicate research results directly to them. As part of the Design Process performance specifications were being developed for the future housing system designed last year. These house designs coordinate and optimize predicted and desirable advances in computerized design processes, materials, components, and manufacturing automation to achieve energy efficiency at reduced first cost. Energy design software were being developed for CAD systems, stressed skin insulating core panel manufacturers; and a prototype energy sales tool. A prototype design was to be developed to integrate one or more subsystems with the building skin. As part of the Manufacturing Process we are developing a manufacturing process simulation and data base to help current and new entrants to the industrialized housing industry in assessing the impact of implementing new manufacturing techniques. For Evaluation we are developing testing plans for six units of housing on the UO campus and the stressed skin insulating core house to be constructed in Oregon. The DOW Chemical test structure will be retrofitted with a tile roof and retested to compare to the dome and conventional construction structures. Calibration of the wind tunnel will be completed so that laboratory tests can be conducted to simulate the ventilation cooling efficiency of houses in design. Research utilization and program management were either aspects of this program.

  18. Examining causes of the urban (inner city) asthma epidemic: Implementing new management strategies.

    Science.gov (United States)

    Szefler, Stanley J

    2016-01-01

    Asthma in the inner city contributes to high morbidity and mortality, and, in school children, reduced school attendance and alteration in academic performance. There is a need to improve asthma care in the inner city by reducing asthma exacerbations. Methods are currently available to predict and prevent seasonal exacerbations of asthma. In addition, new medications are being developed that will be effective in improving pulmonary function and reducing asthma exacerbations. School-centered asthma programs can also be helpful to assist children and clinicians in applying asthma treatment plans and assuring optimal adherence to these plans. PMID:26831839

  19. Ocean Margins Programs, Phase I research summaries

    Energy Technology Data Exchange (ETDEWEB)

    Verity, P. [ed.

    1994-08-01

    During FY 1992, the DOE restructured its regional coastal-ocean programs into a new Ocean Margins Program (OMP), to: Quantify the ecological and biogeochemical processes and mechanisms that affect the cycling, flux, and storage of carbon and other biogenic elements at the land/ocean interface; Define ocean-margin sources and sinks in global biogeochemical cycles, and; Determine whether continental shelves are quantitatively significant in removing carbon dioxide from the atmosphere and isolating it via burial in sediments or export to the interior ocean. Currently, the DOE Ocean Margins Program supports more than 70 principal and co-principal investigators, spanning more than 30 academic institutions. Research funded by the OMP amounted to about $6.9M in FY 1994. This document is a collection of abstracts summarizing the component projects of Phase I of the OMP. This phase included both research and technology development, and comprised projects of both two and three years duration. The attached abstracts describe the goals, methods, measurement scales, strengths and limitations, and status of each project, and level of support. Keywords are provided to index the various projects. The names, addresses, affiliations, and major areas of expertise of the investigators are provided in appendices.

  20. The effects of patient education programs on medication use among asthma and COPD patients: a propensity score matching with a difference-in-difference regression approach

    OpenAIRE

    Sari, Nazmi; Osman, Meric

    2015-01-01

    Background Adherence to medication is one of the critical determinants of successful management of chronic diseases including asthma and chronic obstructive pulmonary disease (COPD). Given that poor adherence with self-management medication is very common among asthma and COPD patients, interventions that improve the use of chronic disease management medications for this patient group have potential to generate positive health outcomes. In an effort to improve asthma and COPD care, the Lung A...

  1. 7 CFR 3406.17 - Program application materials-research.

    Science.gov (United States)

    2010-01-01

    ... RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE 1890 INSTITUTION CAPACITY BUILDING GRANTS PROGRAM Preparation of a Research Proposal § 3406.17 Program application materials—research... 7 Agriculture 15 2010-01-01 2010-01-01 false Program application materials-research....

  2. Environmental research program. 1995 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, N.J.

    1996-06-01

    The objective of the Environmental Research Program is to enhance the understanding of, and mitigate the effects of pollutants on health, ecological systems, global and regional climate, and air quality. The program is multidisciplinary and includes fundamental research and development in efficient and environmentally benign combustion, pollutant abatement and destruction, and novel methods of detection and analysis of criteria and noncriteria pollutants. This diverse group conducts investigations in combustion, atmospheric and marine processes, flue-gas chemistry, and ecological systems. Combustion chemistry research emphasizes modeling at microscopic and macroscopic scales. At the microscopic scale, functional sensitivity analysis is used to explore the nature of the potential-to-dynamics relationships for reacting systems. Rate coefficients are estimated using quantum dynamics and path integral approaches. At the macroscopic level, combustion processes are modelled using chemical mechanisms at the appropriate level of detail dictated by the requirements of predicting particular aspects of combustion behavior. Parallel computing has facilitated the efforts to use detailed chemistry in models of turbulent reacting flow to predict minor species concentrations.

  3. Research and development program, fiscal year 1970

    Energy Technology Data Exchange (ETDEWEB)

    1968-04-01

    The biomedical program of the Laboratory of Nuclear Medicine and Radiation Biology for FY 1970 is conducted within the scope of the following categories: Somatic Effects of Radiation; Combating Detrimental Effects of Radiation; Molecular and Cellular Level Studies; Environmental Radiation Studies; Radiological and Health Physics and Instrumentation; Cancer Research; and Selected Beneficial Applications. The overall objectives of the Laboratory within these areas of the Biology and Medicine Program may be summarized as follows: (1) investigation of the effects of ionizing radiation on systems of biological significance and on living organisms; (2) assessment and study of the immediate and long term consequences of the environmental radioactivity on flora, fauna, and man; (3) development of beneficial uses of ionizing radiation and radioactive substances in medicine and biology; and (4) the conduct of training and educational activities in fields related to the biological and medical aspects of radiation.

  4. 76 FR 11765 - Education Research and Special Education Research Grant Programs; Institute of Education Sciences...

    Science.gov (United States)

    2011-03-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION Education Research and Special Education Research Grant Programs; Institute of Education Sciences; Overview Information; Education Research and Special Education Research Grant Programs; Notice Inviting...

  5. Stay away from asthma triggers

    Science.gov (United States)

    Asthma triggers - stay away from; Asthma triggers - avoiding; Reactive airway disease - triggers; Bronchial asthma - triggers ... to them. Have someone who does not have asthma cut the grass, or wear a facemask if ...

  6. 定喘汤治疗毛细支气管炎临床研究%Clinical research on treating bronchiolitis with the asthma-reliving decoction

    Institute of Scientific and Technical Information of China (English)

    王志敏

    2012-01-01

      Objective: To research the clinical effect of asthma-reliving decoction in treating bronchiolitis. Methods: 66 cases of children with bronchiolitis were randomly divided into the treatment group and the control group, 33 cases in each group. The treatment group was given the asthma-reliving decoction for oral use on the basis of western medicine, while the control group was given only western medicine for anti-infection and symptomatic treatment. Compared the pyretolysis time, tussis extinction time, pulmonary rales extinction time and the total efficiency between the two groups. Results: Compared with the control group, the pyretolysis time, tussis extinction time, pulmonary rales extinction time and the total efficiency of the treatment group had significant difference (P<0.05). Conclusion: The asthma-reliving decoction was effective in treating bronchiolitis.%  目的:研究定喘汤治疗毛细支气管炎临床疗效.方法:66例毛细支气管炎患者随机分为治疗组和对照组各33例,对照组用西药抗感染及对症治疗,治疗组在对照组用药的基础上加中药定喘汤口服,对比两组退热时间、咳嗽消失时间、肺部啰音消失时间及综合疗效.结果:治疗组退热时间、咳嗽消失时间、肺部罗音消失时间及总有效率与对照组相比差异有统计学意义(P<0.05).结论:定喘汤治疗毛细支气管炎效果确切.

  7. Gas Hydrates Research Programs: An International Review

    Energy Technology Data Exchange (ETDEWEB)

    Jorge Gabitto; Maria Barrufet

    2009-12-09

    Gas hydrates sediments have the potential of providing a huge amount of natural gas for human use. Hydrate sediments have been found in many different regions where the required temperature and pressure conditions have been satisfied. Resource exploitation is related to the safe dissociation of the gas hydrate sediments. Basic depressurization techniques and thermal stimulation processes have been tried in pilot efforts to exploit the resource. There is a growing interest in gas hydrates all over the world due to the inevitable decline of oil and gas reserves. Many different countries are interested in this valuable resource. Unsurprisingly, developed countries with limited energy resources have taken the lead in worldwide gas hydrates research and exploration. The goal of this research project is to collect information in order to record and evaluate the relative strengths and goals of the different gas hydrates programs throughout the world. A thorough literature search about gas hydrates research activities has been conducted. The main participants in the research effort have been identified and summaries of their past and present activities reported. An evaluation section discussing present and future research activities has also been included.

  8. Obesity and Asthma

    DEFF Research Database (Denmark)

    Juel, Caroline Trunk-Black; Ulrik, Charlotte Suppli

    2013-01-01

    Asthma is more prevalent in obese compared with normal weight subjects. Our aim has been to review current knowledge of the impact of obesity on asthma severity, asthma control, and response to therapy.Several studies have shown that overweight and obesity is associated with more severe asthma...... and impaired quality of life compared with normal weight individuals. Furthermore, obesity is associated with poorer asthma control, as assessed by asthma control questionnaires, limitations in daily activities, breathlessness and wheezing, use of rescue medication, unscheduled doctor visits, emergency...... department visits, and hospitalizations for acute asthma. Studies of the impact of a high body mass index (BMI) on response to asthma therapy have, however, revealed conflicting results. Most studies show that overweight and obesity is associated with less favorable response to asthma therapy with regard...

  9. PISCES Program: Summary of research, 1988

    Energy Technology Data Exchange (ETDEWEB)

    1988-10-01

    This paper discusses the research of the PISCES Program. Topics discussed are: deuterium pumping by C-C composites and graphites; reduced particle recycling from grooved graphite surfaces; surface analysis of graphite tiles exposed in tokamaks; erosion behavior of redeposition layers from tokamaks (tokamakium); high temperature erosion of graphite; collaboration on TFTR probe measurements of implanted D; spectroscopic studies of carbon containing molecules; presheath profile measurements; biased limiter/divertor experiments; particle transport in the CCT tokamak edge plasma; and experimental studies of biased divertors and limiters. 26 refs., 23 figs. (LSP)

  10. Usability testing of AsthmaWise with older adults.

    Science.gov (United States)

    Burns, Pippa; Jones, Sandra C; Iverson, Don; Caputi, Peter

    2013-05-01

    There are many reasons why online self-management education is attractive to both patients and providers. AsthmaWise, an online self-management program, was developed using a Moodle platform, to enable older adults to learn asthma self-management skills. This study aimed to improve AsthmaWise through conducting: usability testing with a sample of end users; a cognitive walk-through undertaken by an independent health researcher; and assessment of content readability. A Perceived Health Web Site Usability Questionnaire score of 67% was achieved, indicating that there were usability issues that needed to be addressed. The cognitive walk-through and readability assessment identified unique issues that were not identified through usability testing with end users. The testing process allowed issues to be identified and rectified before piloting AsthmaWise, creating a more accessible and refined end product. The involvement of the site designer in the testing process was valuable and is highly recommended. This study shows that usability testing involving both end users and experts is an essential part of the design process that is relatively easy and inexpensive to undertake and can be effectively conducted by a nonexpert. PMID:23542306

  11. INEL BNCT research program: Annual report, 1995

    International Nuclear Information System (INIS)

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1995. Contributions from the principal investigators about their individual projects are included, specifically, physics (treatment planning software, real-time neutron beam measurement dosimetry), and radiation biology (large animal models efficacy studies). Design of a reactor based epithermal neutron extraction facility is discussed in detail. Final results of boron magnetic resonance imagining is included for both borocaptate sodium (BSH) and boronophenylalanine (BPA) in rats, and BSH in humans. Design of an epithermal neutron facility using electron linear accelerators is presented, including a treatise on energy removal from the beam target. Information on the multiple fraction injection of BSH in rats is presented

  12. INEL BNCT Research Program annual report 1994

    International Nuclear Information System (INIS)

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1994. Contributions from the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (treatment planning software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of BSH and BPA is presented and results of 21 spontaneous tumor bearing dogs that have been treated with BNCT at Brookhaven National Laboratory (BNL) are discussed. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Highlights from the First International Workshop on Accelerator-Based Neutron Sources for BNCT are included

  13. INEL BNCT research program publications, 1993

    International Nuclear Information System (INIS)

    This document is a collection of the published reports describing research supporting the Idaho National Engineering Laboratory Boron Neutron Capture Therapy Research Program for calendar year 1993. Contributions from the principal investigators are included, covering chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (tissue and efficacy studies of small and large animal models). These reports have previously appeared in the book: Advances in Neutron Capture Therapy, edited by A. H. Soloway, R. F. Barth, D. E. Carpenter, Plenum Press, 1993. Reports have also appeared in three journals: Angewandte Chemie, Strahlentherapie und Onkologie, and Nuclear Science and Engineering. This individual papers have been indexed separately elsewhere

  14. INEL BNCT research program: Annual report, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1996-04-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1995. Contributions from the principal investigators about their individual projects are included, specifically, physics (treatment planning software, real-time neutron beam measurement dosimetry), and radiation biology (large animal models efficacy studies). Design of a reactor based epithermal neutron extraction facility is discussed in detail. Final results of boron magnetic resonance imagining is included for both borocaptate sodium (BSH) and boronophenylalanine (BPA) in rats, and BSH in humans. Design of an epithermal neutron facility using electron linear accelerators is presented, including a treatise on energy removal from the beam target. Information on the multiple fraction injection of BSH in rats is presented.

  15. Jointly Sponsored Research Program on Energy Related Research

    Energy Technology Data Exchange (ETDEWEB)

    No, author

    2013-12-31

    Cooperative Agreements, DE-FC26-08NT43293, DOE-WRI Cooperative Research and Development Program for Fossil Energy-Related Resources began in June 2009. The goal of the Program was to develop, commercialize, and deploy technologies of value to the nation’s fossil and renewable energy industries. To ensure relevancy and early commercialization, the involvement of an industrial partner was encouraged. In that regard, the Program stipulated that a minimum of 20% cost share be achieved in a fiscal year. This allowed WRI to carry a diverse portfolio of technologies and projects at various development technology readiness levels. Depending upon the maturity of the research concept and technology, cost share for a given task ranged from none to as high as 67% (two-thirds). Over the course of the Program, a total of twenty six tasks were proposed for DOE approval. Over the period of performance of the Cooperative agreement, WRI has put in place projects utilizing a total of $7,089,581 in USDOE funds. Against this funding, cosponsors have committed $7,398,476 in private funds to produce a program valued at $14,488,057. Tables 1 and 2 presented at the end of this section is a compilation of the funding for all the tasks conducted under the program. The goal of the Cooperative Research and Development Program for Fossil Energy-Related Resources was to through collaborative research with the industry, develop or assist in the development of innovative technology solutions that will: • Increase the production of United States energy resources – coal, natural gas, oil, and renewable energy resources; • Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; • Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and • Minimize environmental impacts of energy production and utilization. Success of the Program can be measured by

  16. National Research Council Research Associateships Program with Methane Hydrates Fellowships Program/National Energy Technology Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Basques, Eric O. [National Academy of Sciences, Washington, DC (United States)

    2014-03-20

    This report summarizes work carried out over the period from July 5, 2005-January 31, 2014. The work was carried out by the National Research Council Research Associateships Program of the National Academies, under the US Department of Energy's National Energy Technology Laboratory (NETL) program. This Technical Report consists of a description of activity from 2005 through 2014, broken out within yearly timeframes, for NRC/NETL Associateships researchers at NETL laboratories which includes individual tenure reports from Associates over this time period. The report also includes individual tenure reports from associates over this time period. The report also includes descriptions of program promotion efforts, a breakdown of the review competitions, awards offered, and Associate's activities during their tenure.

  17. Know How to Use Your Asthma Inhaler

    Medline Plus

    Full Text Available ... Asthma among Persons with Current Asthma Asthma and Obesity Percentage of People with Asthma who Smoke Insurance ... Asthma NCHS Asthma FastStats Survey Questions Resources for Health Professionals and Schools Healthcare Professionals Public Health Professionals ...

  18. For Parents of Children with Asthma

    Science.gov (United States)

    ... Asthma > Managing Asthma For Parents of Children with Asthma Your Child's Asthma: A Parent's Guide to Better Breathing This step- ... health considerations you should keep in mind. Diagnosing Asthma in Young Children Most children who have asthma ...

  19. Geothermal Research Program of the US Geological Survey

    Energy Technology Data Exchange (ETDEWEB)

    Duffield, W.A.; Guffanti, M.

    1981-01-01

    The beginning of the Geothermal Research Program, its organization, objectives, fiscal history, accomplishments, and present emphasis. The projects of the Geothermal Research Program are presented along with a list of references.

  20. Obesity and asthma: co-morbidity or causal relationship?

    Science.gov (United States)

    van Huisstede, A; Braunstahl, G J

    2010-09-01

    There is substantial evidence that obesity and asthma are related. "Obese asthma" may be a unique phenotype of asthma, characterized by decreased lung volumes, greater symptoms for a given degree of lung function impairment, destabilization or lack of asthma control, lack of eosinophilic inflammation and a different response to controller medication. Whether this relationship between obesity and asthma is causal or represents co-morbidity due to other factors is unclear. In previous reviews concerning the relationship between obesity and asthma, five hypotheses were put forth. One of these hypotheses is that a low grade systemic inflammation caused by adipokines from the fat tissue causes or enhances bronchial inflammation. In animal models, there is an increasing amount of evidence for the role of adipokines derived from fat tissue in the relationship between obesity and asthma. The data are conflicting in humans. Since obesity is a component of the metabolic syndrome and the metabolic syndrome is also a form of systemic inflammation, it is to be expected that there is a relationship between metabolic syndrome and asthma. The few data that are available show that there is no relationship between metabolic syndrome and asthma, but there is one between the metabolic syndrome and asthma-like symptoms. Further research is needed to confirm the relationship between obesity and asthma in humans, where a rigorous approach in the diagnosis of asthma is essential. PMID:21214041

  1. Assessment of problematic severe asthma in children

    DEFF Research Database (Denmark)

    Carlsen, K. C. L.; Hedlin, G.; Bush, A.;

    2011-01-01

    Assessment of problematic severe asthma in children should be performed in a stepwise manner to ensure an optimal approach. A four-step assessment scheme is proposed. First, a full diagnostic work-up is performed to exclude other diseases which mimic asthma. Secondly, a multi-disciplinary assessm......Assessment of problematic severe asthma in children should be performed in a stepwise manner to ensure an optimal approach. A four-step assessment scheme is proposed. First, a full diagnostic work-up is performed to exclude other diseases which mimic asthma. Secondly, a multi...... in our current knowledge in all these steps are highlighted, and recommendations for current clinical practice and future research are made. The lack of good data and the heterogeneity of problematic severe asthma still limit our ability to optimise the management on an individual basis in this small...

  2. 神经生长因子及其在支气管哮喘中的研究进展%Nerve growth factor and its research progress in bronchial asthma

    Institute of Scientific and Technical Information of China (English)

    刘丹琴; 颜孙舜; 戴元荣

    2015-01-01

    支气管哮喘(简称哮喘)作为呼吸系统中呈逐年上升趋势的一种常见病,给人类社会及家庭均带来了严重的经济负担.尽管激素的使用对哮喘患者的症状有所控制,但激素敏感的出现等,使其发病率和病死率只增不减,追根溯源还是对哮喘的发病机制不完全了解所致,故完善其发病机制的研究,将开拓新的诊疗方向.随着现代分子生物学的发展,目前发现神经生长因子在哮喘的发生发展中起着核心作用,有学者提出了哮喘的“免疫-神经-内分泌网络”的概念,通过多系统的联系,使人们对哮喘的发病机制有了更深的认识,或许将开拓哮喘研究及治疗的新领域.%Bronchial asthma (asthma) is a common disease which is being growth trend in the respiratory system,and brought serious economic burden for human' society and families.As the use of hormones,some symptoms of asthma may be controlled.However,its morbidity and mortality is still increasing because of the presence of the hormone sensitive and so on.Tracing the reason is not clearly about the pathogenesis of asthma.So consummating the research of the asthma pathogenesis will develop new therapeutic direction.With the development of modern molecular biology,nerve growth factor was found that it plays a core role in the occurrence and development of asthma.Some scholars proposed the " immune-nerve-endocrine network" of asthma.Through linking with the multiple system may make people had a deeper understanding of pathogenesis of asthma.Perhaps,it will explore the new areas about the research and treatment of asthma.

  3. Randomized controlled study of CBT in bronchial asthma

    Directory of Open Access Journals (Sweden)

    Grover Naveen

    2007-01-01

    Full Text Available The aim of the present study was to find out efficacy of cognitive behavior therapy, as an adjunct to standard pharmacotherapy, in bronchial asthma. In a random-ized two-group design with pre-and post assessments, forty asthma patients were randomly allotted to two groups: self management group and cognitive behavior therapy group. Both groups were exposed to 6-8 weeks of intervention, asthma self management program and cognitive behavior therapy. Assessment measures used were-Semi structured interview schedule, Asthma Symptom Checklist, Asthma di-ary, Asthma Bother Profile, Hospital Anxiety & Depression Scale, AQLQ and Peak Expiratory Flow Rate. Within group comparison showed significant improvement in both groups at the post assessment. Between group comparisons showed that CBT group reported significantly greater change than that of SM group. Cognitive behavior therapy helps in improving the managment of asthma.

  4. Asthma and cystic fibrosis: A tangled web.

    LENUS (Irish Health Repository)

    Kent, Brian D

    2014-03-01

    Successfully diagnosing concomitant asthma in people with cystic fibrosis (CF) is a challenging proposition, and the utility of conventional diagnostic criteria of asthma in CF populations remains uncertain. Nonetheless, the accurate identification of individuals with CF and asthma allows appropriate tailoring of therapy, and should reduce the unnecessary use of asthma medication in broader CF cohorts. In this review, we discuss the diagnostic challenge posed by asthma in CF, both in terms of clinical evaluation, and of interpretation of pulmonary function testing and non-invasive markers of airway inflammation. We also examine how the role of cross-sectional thoracic imaging in CF and asthma can assist in the diagnosis of asthma in these patients. Finally, we critically appraise the evidence base behind the use of asthma medications in CF populations, with a particular focus on the use of inhaled corticosteroids and bronchodilators. As shall be discussed, the gaps in the current literature make further high-quality research in this field imperative. Pediatr Pulmonol. 2014; 49:205-213. © 2014 Wiley Periodicals, Inc.

  5. Psychosocial Factors in Severe Pediatric Asthma.

    Science.gov (United States)

    Booster, Genery D; Oland, Alyssa A; Bender, Bruce G

    2016-08-01

    Asthma is the most common chronic illness among children in the United States and can impact nearly all aspects of functioning. Most research suggests that children with severe asthma display more emotional and behavioral problems than their healthy peers. These psychological difficulties are associated with increased risk for functional impairments and problematic disease course. Multidisciplinary teams that assess and treat these psychosocial factors using psychoeducational and behavioral interventions are important for children whose asthma is poorly controlled. Future research should examine the ways in which stress, emotions, and immune functions interact, so as to develop more preventative interventions. PMID:27401618

  6. Psychosocial Factors in Severe Pediatric Asthma.

    Science.gov (United States)

    Booster, Genery D; Oland, Alyssa A; Bender, Bruce G

    2016-08-01

    Asthma is the most common chronic illness among children in the United States and can impact nearly all aspects of functioning. Most research suggests that children with severe asthma display more emotional and behavioral problems than their healthy peers. These psychological difficulties are associated with increased risk for functional impairments and problematic disease course. Multidisciplinary teams that assess and treat these psychosocial factors using psychoeducational and behavioral interventions are important for children whose asthma is poorly controlled. Future research should examine the ways in which stress, emotions, and immune functions interact, so as to develop more preventative interventions.

  7. Severe Accident Research Program plan update

    International Nuclear Information System (INIS)

    In August 1989, the staff published NUREG-1365, ''Revised Severe Accident Research Program Plan.'' Since 1989, significant progress has been made in severe accident research to warrant an update to NUREG-1365. The staff has prepared this SARP Plan Update to: (1) Identify those issues that have been closed or are near completion, (2) Describe the progress in our understanding of important severe accident phenomena, (3) Define the long-term research that is directed at improving our understanding of severe accident phenomena and developing improved methods for assessing core melt progression, direct containment heating, and fuel-coolant interactions, and (4) Reflect the growing emphasis in two additional areas--advanced light water reactors, and support for the assessment of criteria for containment performance during severe accidents. The report describes recent major accomplishments in understanding the underlying phenomena that can occur during a severe accident. These include Mark I liner failure, severe accident scaling methodology, source term issues, core-concrete interactions, hydrogen transport and combustion, TMI-2 Vessel Investigation Project, and direct containment heating. The report also describes the major planned activities under the SARP over the next several years. These activities will focus on two phenomenological issues (core melt progression, and fuel-coolant interactions and debris coolability) that have significant uncertainties that impact our understanding and ability to predict severe accident phenomena and their effect on containment performance SARP will also focus on severe accident code development, assessment and validation. As the staff completes the research on severe accident issues that relate to current generation reactors, continued research will focus on efforts to independently evaluate the capability of new advanced light water reactor designs to withstand severe accidents

  8. DOE-EERC jointly sponsored research program

    Energy Technology Data Exchange (ETDEWEB)

    Hendrikson, J.G.; Sondreal, E.A.

    1999-09-01

    U.S. Department of Energy (DOE) Cooperative Agreement DE-FC21-93MC30098 funded through the Office of Fossil Energy and administered at the Federal Energy Technology Center (FETC) supported the performance of a Jointly Sponsored Research Program (JSRP) at the Energy and Environmental Research Center (EERC) with a minimum 50% nonfederal cost share to assist industry in commercializing and effectively applying efficient, nonpolluting energy technologies that can compete effectively in meeting market demands for clean fuels, chemical feedstocks, and electricity in the 21st century. The objective of the JSRP was to advance the deployment of advanced technologies for improving energy efficiency and environmental performance through jointly sponsored research on topics that would not be adequately addressed by the private sector alone. Examples of such topics include the barriers to hot-gas cleaning impeding the deployment of high-efficiency power systems and the search for practical means for sequestering CO{sub 2} generated by fossil fuel combustion. The selection of particular research projects was guided by a combination of DOE priorities and market needs, as provided by the requirement for joint venture funding approved both by DOE and the private sector sponsor. The research addressed many different energy resource and related environmental problems, with emphasis directed toward the EERC's historic lead mission in low-rank coals (LRCs), which represent approximately half of the U.S. coal resources in the conterminous states, much larger potential resources in Alaska, and a major part of the energy base in the former U.S.S.R., East Central Europe, and the Pacific Rim. The Base and JSRP agreements were tailored to the growing awareness of critical environmental issues, including water supply and quality, air toxics (e.g., mercury), fine respirable particulate matter (PM{sub 2.5}), and the goal of zero net CO{sub 2} emissions.

  9. 75 FR 15756 - Small Business Innovation Research Program Policy Directive

    Science.gov (United States)

    2010-03-30

    ... ADMINISTRATION RIN 3244-AF61 Small Business Innovation Research Program Policy Directive AGENCY: U.S. Small... announces a final amendment to the Small Business Innovation Research (SBIR) Program Policy Directive (PD... the Policy Directive; Small Business Innovation Research Program To: The Directors, Small...

  10. A Survey of Campus Coordinators of Undergraduate Research Programs

    Science.gov (United States)

    Hensley, Merinda Kaye; Shreeves, Sarah L.; Davis-Kahl, Stephanie

    2015-01-01

    Interest in supporting undergraduate research programs continues to grow within academic librarianship. This article presents how undergraduate research program coordinators perceive and value library support of their programs. Undergraduate research coordinators from a variety of institutions were surveyed on which elements of libraries and…

  11. Building Technologies Program Multi-Year Program Plan Research and Development 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan 2008 for research and development, including residential and commercial integration, lighting, HVAC and water heating, envelope, windows, and analysis tools.

  12. Developing Asthma-Friendly Childcare Centers with Online Training and Evaluation

    Directory of Open Access Journals (Sweden)

    Alexandra Catherine Hayes Nowakowski

    2016-03-01

    Full Text Available In 2011, the Florida Asthma Coalition began offering its Asthma-Friendly Childcare Center training online. This course teaches childcare center employees the fundamentals of effective asthma management. It covers basic asthma physiology, ways to recognize asthma attacks, techniques to help children experiencing attacks, and strategies to create healthy environments for asthmatics. A team of health services researchers evaluated both years of the online training. Evaluators used a quasi-experimental design with pretest, posttest, and follow-up assessment. Questions measured knowledge gain and retention, user satisfaction, and implementation of management strategies. Over 650 people from nearly all 67 Florida counties took AFCC training online between 2011 and 2013. Test scores improved by a minimum of 11 percentage points in all program years evaluated. Gains in both knowledge and confidence were substantial and highly significant across years. While individual trainees did forget some content on follow-up, they seemed to retain the specific messages most relevant for their own workplaces. Most trainees also planned to implement multiple management strategies recommended by the training.A large majority of participants rated the training as excellent on all quality metrics, including relevance of content and time efficiency of the online format. Nearly all respondents perceived the training as useful for both providing improved care and fulfilling licensure or certification requirements. Many participants also indicated that their centers would pursue formal certification as AFCCs via the program offered by FAC. The online AFCC course performed strongly in its first years, yielding both high participant satisfaction and substantial improvement in workplace asthma management activity. This training holds promise for introducing and improving multidimensional asthma management strategies at childcare facilities nationwide.

  13. Developing Asthma-Friendly Childcare Centers with Online Training and Evaluation.

    Science.gov (United States)

    Nowakowski, Alexandra Catherine Hayes; Carretta, Henry Joseph; Pineda, Nicole; Dudley, Julie Kurlfink; Forrest, Jamie R

    2016-01-01

    In 2011, the Florida Asthma Coalition (FAC) began offering its Asthma-Friendly Childcare Center (AFCC) training online. This course teaches childcare center employees the fundamentals of effective asthma management. It covers basic asthma physiology, ways to recognize asthma attacks, techniques to help children experiencing attacks, and strategies to create healthy environments for asthmatics. A team of health services researchers evaluated both years of the online training. Evaluators used a quasi-experimental design with pretest, posttest, and follow-up assessment. Questions measured knowledge gain and retention, user satisfaction, and implementation of management strategies. Over 650 people from nearly all 67 Florida counties took AFCC training online between 2011 and 2013. Test scores improved by a minimum of 11% points in all program years evaluated. Gains in both knowledge and confidence were substantial and highly significant across years. While individual trainees did forget some content on follow-up, they seemed to retain the specific messages most relevant for their own workplaces. Most trainees also planned to implement multiple management strategies recommended by the training. A large majority of participants rated the training as excellent on all quality metrics, including relevance of content and time efficiency of the online format. Nearly all respondents perceived the training as useful for both providing improved care and fulfilling licensure or certification requirements. Many participants also indicated that their centers would pursue formal certification as AFCCs via the program offered by FAC. The online AFCC course performed strongly in its first years, yielding both high participant satisfaction and substantial improvement in workplace asthma management activity. This training holds promise for introducing and improving multidimensional asthma management strategies at childcare facilities nationwide. PMID:27014676

  14. [Underdiagnosed asthma in third-grade children].

    Science.gov (United States)

    Walus, I; Richard, G; Laquerrière, B; Perucca, M; Tuveri, R; Einbinder, V; Muller, B; Beydon, N

    2016-01-01

    Undiagnosed asthma has been poorly studied before adolescence since it can go unnoticed by parents and doctors. Moreover, it is unusual to look for undiagnosed asthma by directly questioning children on the presence of current respiratory symptoms. Epidemiologic studies show that more adolescents quote symptoms suggestive of asthma than the prevalence of doctor-diagnosed asthma, but respiratory symptoms compatible with asthma remain undetected by parents of younger children more frequently than doctors diagnose asthma in their children. We attempted to evaluate the relevance of a questionnaire used since 2011 by school doctors in Paris to detect asthma. In this questionnaire, the family history of atopy and asthma were completed by the parents when they met the school doctor (last year of preschool) and questions on current respiratory symptoms were answered by third-grade children seen alone by the school doctor. One hundred and thirty-one children out of 1135 children questioned had a positive questionnaire for suspected asthma. In three-quarters of the cases, questionnaires were positive based on the children's answers on their respiratory symptoms (without a positive answer on personal or family history being necessary). The outcome of 41 children screened by the questionnaire was known. Twenty (49%) children had received a final diagnosis of asthma, of whom 12 were put on asthma controllers. Among these 20 children, two children underwent lung function testing and two others underwent tests for allergy. In eight children, tests had been requested by the child's GP, but no final diagnosis was reported by the parents. None of the 13 children in whom asthma was ruled out had any test performed. It was concluded that it is possible to detect undiagnosed asthma in children as young as 8 years by directly asking them about their respiratory symptoms. The knowledge of personal and family history can improve screening for asthma in these children. A more thorough

  15. Applying the Social Ecological Model to Creating Asthma-Friendly Schools in Louisiana

    Science.gov (United States)

    Nuss, Henry J.; Hester, Laura L.; Perry, Mark A.; Stewart-Briley, Collette; Reagon, Valamar M.; Collins, Pamela

    2016-01-01

    Background: In 2010, the Louisiana Asthma Management and Prevention Program (LAMP) implemented the Asthma-Friendly Schools Initiative in high-risk Louisiana populations. The social ecological model (SEM) was used as a framework for an asthma program implemented in 70 state K-12 public schools over 2 years. Methods: Activities included a needs…

  16. Asthma, guides for diagnostic and handling

    International Nuclear Information System (INIS)

    The paper defines the asthma, includes topics as diagnostic, handling of the asthma, special situations as asthma and pregnancy, handling of the asthmatic patient's perioperatory and occupational asthma

  17. Allergies, asthma, and pollen

    Science.gov (United States)

    Reactive airway - pollen; Bronchial asthma - pollen; Triggers - pollen; Allergic rhinitis - pollen ... Things that make allergies or asthma worse are called triggers. It is important to know your triggers because avoiding them is your first step toward feeling better. ...

  18. Asthma - child - discharge

    Science.gov (United States)

    Pediatric asthma - discharge; Wheezing - discharge; Reactive airway disease - discharge ... Your child has asthma , which causes the airways of the lungs to swell and narrow. In the hospital, the doctors and nurses helped ...

  19. Smoking and asthma

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000504.htm Smoking and asthma To use the sharing features on ... your allergies or asthma worse are called triggers. Smoking is a trigger for many people who have ...

  20. Managing Allergies, Asthma 101

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_158635.html Managing Allergies, Asthma 101 Doctor offers advice to students who will ... 3, 2016 (HealthDay News) -- Teens with allergies or asthma who are heading for college later this year ...

  1. Solar Research Programs at IRSOL, Switzerland

    CERN Document Server

    Ramelli, R; Stenflo, J O; Jetzer, P

    2009-01-01

    The Zurich IMaging POLarimeter (ZIMPOL) developed at ETH Zurich and installed permanently at the Gregory Coude Telescope at Istituto Ricerche Solari Locarno (IRSOL) allows a polarimetric precision down to 10^-5 to be reached. This makes it possible to perform several accurate spectro-polarimetric measurements of scattering polarization and to investigate solar magnetic fields through the signatures of the Hanle and Zeeman effects. The research programs are currently being extended to monochromatic imaging of the Stokes vector with a recently installed Fabry-Perot rapidly tunable filter system with a narrow pass band of about 30mA. The spatial resolution is being improved by the installation of an Adaptive Optics system.

  2. INEL BNCT Research Program annual report, 1992

    International Nuclear Information System (INIS)

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1992. Contributions from all the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor targeting compounds, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented, results of 21 spontaneous-tumor-bearing dogs that have been treated with BNCT at the Brookhaven National Laboratory (BNL) Medical Research Reactor (BMRR) are discussed, and predictions for an epithermal-neutron beam at the Georgia Tech Research Reactor (GTRR) are shown. Cellular-level boron detection and localization by secondary ion mass spectrometry, sputter-initiated resonance ionization spectroscopy, low atomization resonance ionization spectroscopy, and alpha track are presented. Boron detection by ICP-AES is discussed in detail. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors with BNCT is presented. Measurement of the epithermal-neutron flux at BNL and comparison to predictions are shown. Calculations comparing the GTRR and BMRR epithermal-neutron beams are also presented. Individual progress reports described herein are separately abstracted and indexed for the database

  3. INEL BNCT Research Program annual report, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1993-05-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1992. Contributions from all the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor targeting compounds, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented, results of 21 spontaneous-tumor-bearing dogs that have been treated with BNCT at the Brookhaven National Laboratory (BNL) Medical Research Reactor (BMRR) are discussed, and predictions for an epithermal-neutron beam at the Georgia Tech Research Reactor (GTRR) are shown. Cellular-level boron detection and localization by secondary ion mass spectrometry, sputter-initiated resonance ionization spectroscopy, low atomization resonance ionization spectroscopy, and alpha track are presented. Boron detection by ICP-AES is discussed in detail. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors with BNCT is presented. Measurement of the epithermal-neutron flux at BNL and comparison to predictions are shown. Calculations comparing the GTRR and BMRR epithermal-neutron beams are also presented. Individual progress reports described herein are separately abstracted and indexed for the database.

  4. Identifying asthma triggers.

    Science.gov (United States)

    McCarty, Justin C; Ferguson, Berrylin J

    2014-02-01

    Asthma has many triggers including rhinosinusitis; allergy; irritants; medications (aspirin in aspirin-exacerbated respiratory disease); and obesity. Paradoxic vocal fold dysfunction mimics asthma and may be present along with asthma. This article reviews each of these triggers, outlining methods of recognizing the trigger and then its management. In many patients more than one trigger may be present. Full appreciation of the complexity of these relationships and targeted therapy to the trigger is needed to best care for the patient with asthma.

  5. Genetics of asthma

    DEFF Research Database (Denmark)

    Thomsen, Simon F

    2015-01-01

    Asthma runs in families, and children of asthmatic parents are at increased risk of asthma. Prediction of disease risk is pivotal for the clinician when counselling atopic families. However, this is not always an easy task bearing in mind the vast and ever-increasing knowledge about asthma genetics...... of methods and advances in asthma genetics in an attempt to help the clinician keep track of the most important knowledge in the field....

  6. Asthma in Africa

    OpenAIRE

    Emmanuel O D Addo-Yobo; Ashley Woodcock; Adorkor Allotey; Benjamin Baffoe-Bonnie; David Strachan; Adnan Custovic

    2007-01-01

    Editors' Summary Background. The proportion of children with asthma is thought to be increasing worldwide, and particularly among children that live in more developed countries. However, it is not clear why this is, since many different aspects of lifestyle and the environment have been linked with the onset of asthma. In Africa, asthma has typically been thought of as being very uncommon, and indeed in many African dialects there is no word for asthma or the symptoms, such as wheezing, that ...

  7. FY 1995 research highlights: PNL accomplishments in OER programs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    Pacific Northwest Laboratory (PNL) conducts fundamental and applied research in support of the US Department of Energy`s (DOE) core missions in science and technology, environmental quality, energy resources, and national security. Much of this research is funded by the program offices of DOE`s Office of Energy Research (DOE-ER), primarily the Office of Basic Energy Sciences (BES) and the Office of Health and Environmental Research (OHER), and by PNL`s Laboratory Directed Research and Development (LDRD) Program. This document is a collection of research highlights that describe PNL`s accomplishments in DOE-ER funded programs during Fiscal Year 1995. Included are accomplishments in research funded by OHER`s Analytical Technologies, Environmental Research, Health Effects, General Life Sciences, and Carbon Dioxide Research programs; BES`s Materials Science, Chemical Sciences, Engineering and Geoscience, and Applied Mathematical Sciences programs; and PNL`s LDRD Program. Summaries are given for 70 projects.

  8. Antifungals in severe asthma

    NARCIS (Netherlands)

    Parulekar, Amit D.; Diamant, Zuzana; Hanania, Nicola A.

    2015-01-01

    Purpose of review Despite guideline-based treatment, many patients with severe asthma continue to have uncontrolled disease. Fungal allergy is being increasingly recognized in the pathogenesis of severe asthma. Limited data exist on the approach to treatment of fungal asthma. This review summarizes

  9. Obesity and asthma

    DEFF Research Database (Denmark)

    Ali, Zarqa; Ulrik, Charlotte Suppli

    2013-01-01

    Epidemiological data has established increasing adiposity as a risk factor for incident asthma. However, the mechanisms underlying the association between obesity and asthma are incompletely understood. In the present paper, we review current knowledge of possible mechanisms mediating the observed...... association between obesity and asthma....

  10. Do Allergies Cause Asthma?

    Science.gov (United States)

    ... Smoothie Pregnant? Your Baby's Growth Do Allergies Cause Asthma? KidsHealth > For Parents > Do Allergies Cause Asthma? Print A A A Text Size en español ¿Causan asma las alergias? My daughter has asthma and I'm worried that her younger brother ...

  11. Swimming and Persons with Mild Persistant Asthma

    OpenAIRE

    Mirjana Arandelovic; Ivana Stankovic; Maja Nikolic

    2007-01-01

    The aim of our study was to analyze the effect of recreational swimming on lung function and bronchial hyperresponsiveness (BHR) in patients with mild persistent asthma. This study included 65 patients with mild persistent asthma, who were divided into two groups: experimental group A (n = 45) and control group B (n = 20). Patients from both groups were treated with low doses of inhaled corticosteroids (ICS) and short-acting β2 agonists salbutamol as needed. Our program for patients in group ...

  12. INEL BNCT Research Program annual report 1994

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R. [ed.

    1995-11-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Research Program for calendar year 1994. Contributions from the principal investigators about their individual projects are included, specifically, chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (treatment planning software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (small and large animal models tissue studies and efficacy studies). Information on the potential toxicity of BSH and BPA is presented and results of 21 spontaneous tumor bearing dogs that have been treated with BNCT at Brookhaven National Laboratory (BNL) are discussed. Several boron carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Highlights from the First International Workshop on Accelerator-Based Neutron Sources for BNCT are included. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database.

  13. INEL BNCT Research Program Annual Report 1993

    Energy Technology Data Exchange (ETDEWEB)

    Venhuizen, J.R.

    1994-08-01

    This report is a summary of the progress and research produced for the Idaho National Engineering Laboratory Boron Neutron Capture Therapy Research Program for calendar year 1993. Contributions from all the principal investigators are included, covering chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, boron drug analysis), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (tissue and efficacy studies of small and large animal models). Information on the potential toxicity of borocaptate sodium and boronophenylalanine is presented. Results of 21 spontaneous-tumor-bearing dogs that have been treated with boron neutron capture therapy at the Brookhaven National Laboratory are updated. Boron-containing drug purity verification is discussed in some detail. Advances in magnetic resonance imaging of boron in vivo are discussed. Several boron-carrying drugs exhibiting good tumor uptake are described. Significant progress in the potential of treating pituitary tumors is presented. Measurement of the epithermal-neutron flux of the Petten (The Netherlands) High Flux Reactor beam (HFB11B), and comparison to predictions are shown.

  14. Asthma-related emergency department use: current perspectives.

    Science.gov (United States)

    Johnson, Laurie H; Chambers, Patricia; Dexheimer, Judith W

    2016-01-01

    Asthma is one of the most common chronic pediatric diseases. Patients with asthma often present to the emergency department for treatment for acute exacerbations. These patients may not have a primary care physician or primary care home, and thus are seeking care in the emergency department. Asthma care in the emergency department is multifaceted to treat asthma patients appropriately and provide quality care. National and international guidelines exist to help drive clinical care. Electronic and paper-based tools exist for both physicians and patients to help improve emergency, home, and preventive care. Treatment of patients with asthma should include the acute exacerbation, long-term management of controller medications, and controlling triggers in the home environment. We will address the current state of asthma research in emergency medicine in the US, and discuss some of the resources being used to help provide a medical home and improve care for patients who suffer from acute asthma exacerbations. PMID:27471415

  15. Franco-Japanese Research Collaboration on Constraint Programming

    OpenAIRE

    Benhamou, Frédéric; Ceberio, Martine; Codognet, Philippe; Hosobe, Hiroshi; Jermann, Christophe; Satoh, Ken; Ueda, Kazunori

    2006-01-01

    Constraint programming is an emergent technology that allows modeling and solving various problems in many areas such as artificial intelligence, computer programming, computer-aided design, computer graphics, and user interfaces. In this report, we provide recent activities of research collaboration on constraint programming conducted by the authors and other researchers in France and Japan. First, we outline our joint research projects on constraint programming, and then present the backgro...

  16. Asthma phenotypes and IgE responses.

    Science.gov (United States)

    Froidure, Antoine; Mouthuy, Jonathan; Durham, Stephen R; Chanez, Pascal; Sibille, Yves; Pilette, Charles

    2016-01-01

    The discovery of IgE represented a major breakthrough in allergy and asthma research, whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti-IgE biotherapy. Novel facets of the complex link between IgE and asthma have been highlighted by the effect of this treatment and by basic research. In parallel, asthma phenotyping recently evolved to the concept of endotypes, relying on identified/suspected pathobiological mechanisms to phenotype patients, but has not yet clearly positioned IgE among biomarkers of asthma.In this review, we first summarise recent knowledge about the regulation of IgE production and its main receptor, FcεRI. In addition to allergens acting as classical IgE inducers, viral infections as well as air pollution may trigger the IgE pathway, notably resetting the threshold of IgE sensitivity by regulating FcεRI expression. We then analyse the place of IgE in different asthma endo/phenotypes and discuss the potential interest of IgE among biomarkers in asthma.

  17. AECL research programs in life sciences

    International Nuclear Information System (INIS)

    The present report summarizes the current research activities in life sciences in the Atomic Energy of Canada Limited-Research Company. The research is carried out at its two main research sites: the Chalk River Nuclear Laboratories and the Whiteshell Nuclear Research Establishment. The summaries cover the following areas of research: radiation biology, medical biophysics, epidemiology, environmental research and dosimetry. (author)

  18. Center Independent Research & Developments: JPL IRAD Program

    Data.gov (United States)

    National Aeronautics and Space Administration — Innovative projects are sought in the areas of basic research, fundamental research, applied research, development and systems and other concept formulation...

  19. Asthma in the elderly

    OpenAIRE

    Domenico Lorenzo Urso

    2012-01-01

    As the population increases in age, the diseases of older age will have increasing prevalence and place a greater burden on the health system. Despite asthma being usually considered a disease of younger people, asthma mortality is currently greatest in the over 55 age-group. Symptoms and emergency presentations for health care due to asthma place a great burden on the quality of life of those over age 55 with asthma. Asthma in older people is under-diagnosed due to patient and physiological ...

  20. ERDA's bicentennial thermionic research and technology program

    International Nuclear Information System (INIS)

    The status of the ERDA Thermionic Research and Technology Program is addressed. The principal objectives of this program continue to be: (1) to provide very high specific power thermionic systems for NASA nuclear electric propulsion missions, and (2) by the use of thermionic topping cycles for coal-burning steam generating plants, to increase the overall plant efficiency from current values of about 40% to projected values of 50% or higher, without significantly increasing the unit capital cost, the operating and maintenance costs, or the amount of fuel required. Underlying the achievement of these objectives is the successful attainment of the thermionic technology goals viz., (1) low collector work function (approximately 1.0 eV), stable for long lifetime at design operating temperatures, and (2) reduction or elimination of the plasma arc drop, or elimination of the plasma altogether by achieving ionization in some way other than by volume ionization of the cesium by hot electrons from the emitter. Achieving these objectives will result in a converter efficiency of approximately 30% at a lower, more tractable emitter temperature, approximately 1400K. Also of increasing significance are the identification of engineering problems arising out of systems studies and component hardware development, the solutions to which are necessary for the reduction of thermionic technology to sound engineering practice for both space and terrestrial applications. Typical of this class of problems is the development of corrosion-resistant hot shell materials for use in the harsh, high temperature, combustion chamber environment of coal-fired furnaces, for the ERDA thermionic topping cycle application

  1. Occupational and environmental lung disease: occupational asthma.

    Science.gov (United States)

    Stenton, S C

    2010-01-01

    Occupational exposures cause 10-15% of new-onset asthma in adults, and that represents a considerable health and economic burden. Exposure to many causative agents is now well controlled but workplace practices are constantly evolving and new hazards being introduced. Overall, there is no good evidence that the incidence of occupational asthma is decreasing. Evidence-based guidelines such as those published by the British Occupational Health research Foundation and Standards of Care documents should help raise awareness of the problem and improve management. Key targets include the control of occupational exposures, a high index of suspicion in any adult with new onset asthma, and early detailed investigation.

  2. The IRSN research program on corium spreading

    Energy Technology Data Exchange (ETDEWEB)

    Jean-Claude Latche [Institut de Radioprotection et de Surete Nucleaire (IRSN) Major Accident Prevention Division (DPAM) Bat 702, BP3, 13115 St Paul-lez-Durance (France)

    2006-07-01

    Full text of publication follows: Ensuring the corium confinement within the containment is part of the design requirements for the European Pressurized Reactor (EPR). A specific strategy has then been imagined to collect and cool down the corium: it relies on corium retention in the reactor pit up to complete discharge from the vessel, then on spreading in a 170 m{sup 2} large core catcher, followed by flooding by water flowing upon its surface and within a cooling device located under the basemat. As the heat is generated inside the corium as a volumetric power source, the heat flux to be evacuated per basemat surface unit grows with the corium height. Consequently, a research program, aimed at assessing the possibility to widely spread the corium, and correspondingly trying to forecast the maximal possible height of melt that needs to be anticipated, has been lead at the 'Institut de Radioprotection et de Surete Nucleaire' during the last decade. It involved the development of a simulation software, namely the CROCO code, which modelling was consolidated and qualified by various experimental programs. These latter schematically fall into two categories: experiments using simulant fluids, at low - CORINE1 - or high temperature - KATS - and experiments using prototypical melts - e.g. VULCANO2. The CORINE tests were equipped with a very accurate instrumentation, and provided an in-depth characterization of the corium flow, including the knowledge of the local temperature within the melt. The tests program included spreading with crust growth at the contact with the basemat, possibly with gas sparging to simulate the effects of corium/concrete interaction during the spreading. They were complemented by the KATS tests, which simulant material was heated at sufficiently high temperature to observe the effects of heat radiation to the atmosphere and interaction with the substrate. Finally, the VULCANO program, using prototypical corium melts, gave insight

  3. Research undertaken by CAS scientists with support of "973 Program"

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The National Basic Research Program (dubbed as the "973 Program") is China's on-going national keystone basic research program, which was approved by the Chinese government in June 1 997 and is organized and implemented by the Ministry of Science and Technology.

  4. Ecological Research Division Theoretical Ecology Program. [Contains abstracts

    Energy Technology Data Exchange (ETDEWEB)

    1990-10-01

    This report presents the goals of the Theoretical Ecology Program and abstracts of research in progress. Abstracts cover both theoretical research that began as part of the terrestrial ecology core program and new projects funded by the theoretical program begun in 1988. Projects have been clustered into four major categories: Ecosystem dynamics; landscape/scaling dynamics; population dynamics; and experiment/sample design.

  5. Asthma and pregnancy.

    Science.gov (United States)

    Vatti, Rani Reddy; Teuber, Suzanne S

    2012-08-01

    Asthma is probably the most common serious medical disorder that may complicate pregnancy. A third of pregnant women with asthma will experience worsening of their symptoms, a third will see improvement of their symptoms and a third will see no change. The primary goal is to maintain optimal control of asthma for maternal health and well-being as well as fetal maturation. Vital patient education should cover the use of controller medication, avoidance of asthma triggers and early treatment of asthma exacerbations. Proper asthma management should ideally be started in the preconception period. Since smoking is probably the most modifiable risk factor of asthma, pregnant woman should avoid active and passive smoking. Acute asthma exacerbation during the first trimester is associated with an increased risk of congenital malformations. Poorly controlled asthma is associated with low birth weight, preeclampsia, and preterm birth. Medications used for asthma control in the non-pregnant population are generally the same in pregnancy with a few exceptions. Inhaled corticosteroids (ICS) are the preferred controller therapy. Budesonide is the preferred ICS. Long-acting B-agonists (LABA) are the preferred add-on therapy to medium to high dose ICS. Major triggers for asthma exacerbations during pregnancy are viral infections and ICS nonadherence. PMID:21858482

  6. Obesity and asthma

    DEFF Research Database (Denmark)

    Sivapalan, Pradeesh; Diamant, Zuzana; Ulrik, Charlotte Suppli

    2015-01-01

    PURPOSE OF REVIEW: Obesity has significant impact on asthma incidence and manifestations. The purpose of the review is to discuss recent observations regarding the association between obesity and asthma focusing on underlying mechanisms, clinical presentation, response to therapy and effect...... of weight reduction. RECENT FINDINGS: Clinical and epidemiological studies indicate that obese patients with asthma may represent a unique phenotype, which is more difficult to control, less responsive to asthma medications and by that may have higher healthcare utilization. A number of common comorbidities...... have been linked to both obesity and asthma, and may, therefore, contribute to the obese-asthma phenotype. Furthermore, recently published studies indicate that even a modest weight reduction can improve clinical manifestations and outcome of asthma. SUMMARY: Compared with normal-weight patients, obese...

  7. Nuclear Plant Aging Research (NPAR) program plan

    International Nuclear Information System (INIS)

    The nuclear plant aging research described in this plan is intended to resolve issues related to the aging and service wear of equipment and systems at commercial reactor facilities and their possible impact on plant safety. Emphasis has been placed on identification and characterization of the mechansims of material and component degradation during service and evaluation of methods of inspection, surveillance, condition monitoring and maintenance as means of mitigating such effects. Specifically the goals of the program are as follows: (1) to identify and characterize aging and service wear effects which, if unchecked, could cause degradation of structures, components, and systems and thereby impair plant safety; (2) to identify methods of inspection, surveillance and monitoring, or of evaluating residual life of structures, components, and systems, which will assure timely detection of significant aging effects prior to loss of safety function; and (3) to evaluate the effectiveness of storage, maintenance, repair and replacement practices in mitigating the rate and extent of degradation caused by aging and service wear

  8. [Nursing care of a school-age child with asthma: an ecological system theory approach].

    Science.gov (United States)

    Tzeng, Yu-Fen; Gau, Bih-Shya

    2012-02-01

    This research applied the Ecological System Theory of Dr. Bronfenbrenner (1979) to evaluate and analyze the impact of a school-age asthmatic child's ecological environment on the child's development. This project ran from March 16th to April 16th, 2010. A full range of data was collected during clinical care, outpatient follow-up services, telephone interviews, home visits, and school visits and then identified and analyzed. Results indicated that the family, household environment, campus, teachers, classmates, physical education program, and medical staffs comprised the most immediate microsystem and that parents, school nurses, teachers, and classmates formed the child's mesosystem. Researchers found a lack of understanding and appreciation in the mesosystem regarding asthmatic patient care needs. Hidden factors in the environment induced asthma, which eventually caused the child to be unable to obtain necessary medical care assistance. The exosystem reflected adequacy of the family social economy. The father's flexible working hours allowed him to allocate more time to childcare responsibilities. The government Asthma Medical Payment program also facilitated effective care. The macrosystem demonstrated parental cognition related to asthma treatment and caring to be deeply influenced by local customs. Thus, rather than using advanced medical treatments, parents preferred to follow traditional Chinese medicinal practices. Evaluation using the Ecological of Human Development Theory showed the subject's ecology environment relationships as based upon a foundation of family and school. Therefore, active family and school support for an asthma management plan appropriate to the subject's needs was critical. Asthma symptoms were better controlled after the child and his parents invested greater effort in mastering asthma management protocols. PMID:22314656

  9. [Nursing care of a school-age child with asthma: an ecological system theory approach].

    Science.gov (United States)

    Tzeng, Yu-Fen; Gau, Bih-Shya

    2012-02-01

    This research applied the Ecological System Theory of Dr. Bronfenbrenner (1979) to evaluate and analyze the impact of a school-age asthmatic child's ecological environment on the child's development. This project ran from March 16th to April 16th, 2010. A full range of data was collected during clinical care, outpatient follow-up services, telephone interviews, home visits, and school visits and then identified and analyzed. Results indicated that the family, household environment, campus, teachers, classmates, physical education program, and medical staffs comprised the most immediate microsystem and that parents, school nurses, teachers, and classmates formed the child's mesosystem. Researchers found a lack of understanding and appreciation in the mesosystem regarding asthmatic patient care needs. Hidden factors in the environment induced asthma, which eventually caused the child to be unable to obtain necessary medical care assistance. The exosystem reflected adequacy of the family social economy. The father's flexible working hours allowed him to allocate more time to childcare responsibilities. The government Asthma Medical Payment program also facilitated effective care. The macrosystem demonstrated parental cognition related to asthma treatment and caring to be deeply influenced by local customs. Thus, rather than using advanced medical treatments, parents preferred to follow traditional Chinese medicinal practices. Evaluation using the Ecological of Human Development Theory showed the subject's ecology environment relationships as based upon a foundation of family and school. Therefore, active family and school support for an asthma management plan appropriate to the subject's needs was critical. Asthma symptoms were better controlled after the child and his parents invested greater effort in mastering asthma management protocols.

  10. [Asthma clinical practice guidelines: advantages and pitfalls].

    Science.gov (United States)

    Plaza, Vicente; Bellido-Casado, Jesús; Alonso-Coello, Pablo; Rodrigo, Gustavo

    2009-01-01

    The Clinical Practice Guidelines on asthma have contributed towards unifying concepts and reaching a consensus on performances between different professional groups. However, they have failed in the overall improvement in the management of asthma, the final objective that they are meant to achieve. Today, almost 20 years after they appeared, the majority of asthmatic patients are still inadequately controlled, partly due to lack of follow up by doctors and the rest of health care staff who have to look after them. This lack of follow up of these recommendations is probably associated with a lack of well structured planning in their circulation and implementation. Also, although the recommendations of these guidelines agree in what is essential, they differ in other aspects, which in turn could be determining factors in clinical practice. The purpose of this article has been to establish the main differences in the recommendations that the principal clinical practice guidelines on the disease propose on the diagnosis, classification and treatment of asthma. To do this we have compared, The British Guideline on the Management of Asthma 2007, The Global Strategy for Asthma Management and Prevention/Global Initiative for Asthma 2006 (GINA), the National Prevention program for Education on Asthma (Programa Nacional de Prevención para la Educación del Asma) (NAEPP), the Spanish Guide for the Management of Asthma (Guía Española para el Manejo del Asma 2003) (GEMA) and the ALAT y SEPAR guides, Latin-America and Spain. Recommendations for the Prevention and Treatment of Asthma Exacerbation (América Latina y España. Recomendaciones para la Prevención y el Tratamiento de la Exacerbación Asmática 2008) (ALERTA).

  11. DECONTAMINATION SYSTEMS AND INFORMATION RESEARCH PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    Echol E. Cook, Ph.D., PE.

    1998-11-01

    During the five plus years this Cooperative Agreement existed, more than 45 different projects were funded. Most projects were funded for a one year period but there were some, deemed of such quality and importance, funded for multiple years. Approximately 22 external agencies, businesses, and other entities have cooperated with or been funded through the WVU Cooperative Agreement over the five plus years. These external entities received 33% of the funding by this Agreement. The scope of this Agreement encompassed all forms of hazardous waste remediation including radioactive, organic, and inorganic contaminants. All matrices were of interest; generally soil, water, and contaminated structures. Economic, health, and regulatory aspects of technologies were also within the scope of the agreement. The highest priority was given to small businesses funded by the Federal Energy Technology Center (FETC) and Department of Energy (DOE) involved in research and development of innovative remediation processes. These projects were to assist in the removal of barriers to development and commercialization of these new technologies. Studies of existing, underdeveloped technologies, were preferred to fundamental research into remediation technologies. Sound development of completely new technologies was preferred to minor improvements in existing methods. Solid technological improvements in existing technologies or significant cost reduction through innovative redesign were the preferred projects. Development, evaluation, and bench scale testing projects were preferred for the WVU research component. In the effort to fill gaps in current remediation technologies, the worth of the WVU Cooperative Agreement was proven. Two great technologies came out of the program. The Prefabricated Vertical Drain Technology for enhancing soil flushing was developed over the 6-year period and is presently being demonstrated on a 0.10 acre Trichloroethylene contaminated site in Ohio. The Spin

  12. DECONTAMINATION SYSTEMS AND INFORMATION RESEARCH PROGRAM; FINAL

    International Nuclear Information System (INIS)

    During the five plus years this Cooperative Agreement existed, more than 45 different projects were funded. Most projects were funded for a one year period but there were some, deemed of such quality and importance, funded for multiple years. Approximately 22 external agencies, businesses, and other entities have cooperated with or been funded through the WVU Cooperative Agreement over the five plus years. These external entities received 33% of the funding by this Agreement. The scope of this Agreement encompassed all forms of hazardous waste remediation including radioactive, organic, and inorganic contaminants. All matrices were of interest; generally soil, water, and contaminated structures. Economic, health, and regulatory aspects of technologies were also within the scope of the agreement. The highest priority was given to small businesses funded by the Federal Energy Technology Center (FETC) and Department of Energy (DOE) involved in research and development of innovative remediation processes. These projects were to assist in the removal of barriers to development and commercialization of these new technologies. Studies of existing, underdeveloped technologies, were preferred to fundamental research into remediation technologies. Sound development of completely new technologies was preferred to minor improvements in existing methods. Solid technological improvements in existing technologies or significant cost reduction through innovative redesign were the preferred projects. Development, evaluation, and bench scale testing projects were preferred for the WVU research component. In the effort to fill gaps in current remediation technologies, the worth of the WVU Cooperative Agreement was proven. Two great technologies came out of the program. The Prefabricated Vertical Drain Technology for enhancing soil flushing was developed over the 6-year period and is presently being demonstrated on a 0.10 acre Trichloroethylene contaminated site in Ohio. The Spin

  13. Situated Research Design and Methodological Choices in Formative Program Evaluation

    Science.gov (United States)

    Supovitz, Jonathan

    2013-01-01

    Design-based implementation research offers the opportunity to rethink the relationships between intervention, research, and situation to better attune research and evaluation to the program development process. Using a heuristic called the intervention development curve, I describe the rough trajectory that programs typically follow as they…

  14. Perceived Value of Required Research in Orthodontic Postgraduate Programs.

    Science.gov (United States)

    Lancaster, Diana M.; And Others

    Graduates' perceptions concerning the value of required research experience in orthodontic postdoctoral programs were determined. Factors in the postdoctoral research program that provided positive/negative experiences were also identified. Fifteen attitude statements concerning the merits of required research projects and demographic items on the…

  15. 77 FR 20802 - Applications for New Awards; Education Research and Special Education Research Grant Programs...

    Science.gov (United States)

    2012-04-06

    ... Education Research Grant Programs. The chart at the end of the March 6 NIA (see 77 FR 13297, 13302-13303... three competitions contained errors: Research on Statistical and Research Methodology in Education (CFDA... Applications for New Awards; Education Research and Special Education Research Grant Programs;...

  16. Federal Geothermal Research Program Update - Fiscal Year 2001

    Energy Technology Data Exchange (ETDEWEB)

    Laney, P.T.

    2002-08-31

    This Federal Geothermal Program Research Update reviews the specific objectives, status, and accomplishments of DOE's Geothermal Program for Federal Fiscal Year (FY) 2001. The information contained in this Research Update illustrates how the mission and goals of the Office of Geothermal Technologies are reflected in each R&D activity. The Geothermal Program, from its guiding principles to the most detailed research activities, is focused on expanding the use of geothermal energy.

  17. Heavy Truck Clean Diesel Cooperative Research Program

    Energy Technology Data Exchange (ETDEWEB)

    Milam, David

    2006-12-31

    This report is the final report for the Department of Energy on the Heavy Truck Engine Program (Contract No. DE-FC05-00OR22806) also known as Heavy Truck Clean Diesel (HTCD) Program. Originally, this was scoped to be a $38M project over 5 years, to be 50/50 co-funded by DOE and Caterpillar. The program started in June 2000. During the program the timeline was extended to a sixth year. The program completed in December 2006. The program goal was to develop and demonstrate the technologies required to enable compliance with the 2007 and 2010 (0.2g/bhph NOx, 0.01g/bhph PM) on-highway emission standards for Heavy Duty Trucks in the US with improvements in fuel efficiency compared to today's engines. Thermal efficiency improvement from a baseline of 43% to 50% was targeted.

  18. Fatores de risco para visitas à emergência por exacerbações de asma em pacientes de um programa de controle da asma e rinite alérgica em Feira de Santana, BA Risk factors for ER visits due to asthma exacerbations in patients enrolled in a program for the control of asthma and allergie rhinitis in Feira de Santana, Brazil

    Directory of Open Access Journals (Sweden)

    Heli Vieira Brandão

    2009-12-01

    Full Text Available OBJETIVO: Determinar os fatores de risco para atendimentos de emergência por exacerbações da asma em pacientes acompanhados em um centro de referência. MÉTODOS: Estudo de coorte prospectiva de 253 crianças e adultos com asma e monitorados por 12 meses no Centro de Referência do Programa de Controle da Asma e Rinite Alérgica de Feira de Santana, BA. RESULTADOS: As exacerbações foram frequentes, e 36,5% dos pacientes buscaram assistência em serviços de emergência no período de 12 meses. Os fatores de risco associados às exacerbações foram idade > 20 anos (OR = 1,34; IC95%: 1,06-1,70; residência em zona urbana (OR = 1,19; IC95%: 1,06-1,33; baixa escolaridade (OR = 1,53; IC95%: 1,00-2,39; asma grave (OR = 1,65; IC95%: 1,24-2,18; e rinite crônica (OR = 2,20: IC95%: 1,00-4,80. CONCLUSÕES: Ter de rinite crônica, asma mais grave e baixa escolaridade foram os principais fatores de risco para atendimentos de emergência por exacerbações da asma nesta coorte. Esses resultados são semelhantes àqueles descritos para pacientes com asma sem tratamento regular.OBJECTIVE: To determine the risk factors for ER visits due to asthma exacerbations in patients monitored at a referral center. METHODS: Prospective cohort study of 253 outpatients (children and adults with asthma who were monitored for 12 months at the Referral Center of the Program for the Control of Asthma and Allergic Rhinitis in the city of Feira de Santana, Brazil. RESULTS: Exacerbations were common, and 36.5% of the patients sought ER treatment within the twelve-month period. The risk factors for asthma exacerbations were being over 20 years of age (OR = 1.34: (95% CI: 1.06-1.70, residing in an urban area (OR = 1.19; 95% CI: 1.06-1.33; having a low level of education (OR = 1.53: 95% CI: 1.00-2.39; having severe asthma (OR = 1.65; 95% CI: 1.24-2.18; and having chronic rhinitis (OR = 2.20; 95% CI: 1.00-4.80. CONCLUSIONS: In this cohort, having chronic rhinitis, having asthma

  19. Fusion Research Center, theory program. Progress report

    International Nuclear Information System (INIS)

    The Texas FRC theory program is directed primarily toward understanding the initiation, heating, and confinement of tokamak plasmas. It supports and complements the experimental programs on the TEXT and PRETEXT devices, as well as providing information generally applicable to the national tokamak program. A significant fraction of the Center's work has been carried out in collaboration with, or as a part of, the program of the Institute for Fusion Studies (IFS). During the past twelve months, 14 FRC theory reports and 12 IFS reports with partial FRC support have been issued

  20. Asthma & Physical Activity in the School

    Science.gov (United States)

    ... Some students experience asthma symptoms only when they exercise. Asthma varies from student to student and often from ... activities and other regular school activities. Table 1: BENEFITS OF ASTHMA CONTROL With good asthma management, students with asthma ...

  1. Know How to Use Your Asthma Inhaler

    Medline Plus

    Full Text Available ... 1 MB] ASL Asthma Film Asthma Clinical Guidelines Air Pollution & Respiratory Health Know How to Use Your Asthma ... 1 MB] ASL Asthma Film Asthma Clinical Guidelines Air Pollution & Respiratory Health File Formats Help: How do I ...

  2. Know How to Use Your Asthma Inhaler

    Medline Plus

    Full Text Available ... MB] ASL Asthma Film Asthma Clinical Guidelines Air Pollution & Respiratory Health Know How to Use Your Asthma ... MB] ASL Asthma Film Asthma Clinical Guidelines Air Pollution & Respiratory Health File Formats Help: How do I ...

  3. Examining the association between childhood asthma and parent and grandparent asthma status: Implications for Practice

    OpenAIRE

    Valerio, Melissa A.; Andreski, Patricia M.; Schoeni, Robert F.; McGonagle, Katherine A.

    2010-01-01

    Examination of intergenerational asthma beyond maternal asthma has been limited. The association between childhood asthma and intergenerational asthma status among a national cohort of children was examined.

  4. Trends in Asthma Prevalence, Health Care Use, and Mortality in the United States, 2001-2010

    Science.gov (United States)

    ... that [sample child] had asthma?" and "Does [sample child] still have asthma?" Poverty status or percentage of poverty level : Based on ... National Institutes of Health. National Asthma Education and Prevention Program. Expert ... Bureau. Poverty . 2011. Schenker N, Raghunathan TE, Chiu PL, et ...

  5. Pacific Northwest Laboratory Alaska (ARCTIC) research program

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, W.C.; Eberhardt, L.E.

    1980-03-01

    The current program continues studies of arctic ecosystems begun in 1959 as part of the Cape Thompson Program. Specific ecosystem aspects include studies of the ecology of arctic and red foxes, small mammel and bird population studies, lichen studies, and radiation ecology studies. (ACR)

  6. Negotiating Researcher Roles in Ethnographic Program Evaluation

    Science.gov (United States)

    Harklau, Linda; Norwood, Rachel

    2005-01-01

    We argue for the value of postmodernism in illuminating the roles or subject positions of ethnographic program evaluators. Drawing upon data from an ethnographic study of a summer college readiness program for African American, Asian American, and Anglo youth, we explore how postmodern theories can provide insights into the multiple roles of…

  7. Th17/Treg role in the pathogenesis of bronchial asthma and research progress%Th17/Treg在支气管哮喘发病机制中的作用及研究进展

    Institute of Scientific and Technical Information of China (English)

    龚臣; 邓静敏

    2013-01-01

    The proposed Th17/Treg breakthrough the limitations of the classical theory Th1/Th2 imbalance,IL-17,IL-10 has caused great concern in the pathogenesis of bronchial asthma (asthma),however,based on the lack of depth systemic between them in the pathogenesis of asthma.This article briefly reviewed Th17/Treg cell and factor IL-17,IL-10,neutrophil relationship with asthma research progress.%Th17/Treg的提出突破了经典理论Th1/Th2失衡的局限性,IL-17、IL-10在支气管哮喘(简称哮喘)中的发生发展已经引起高度关注,然而基于它们之间在哮喘发病机制中缺乏深度和系统性,本文就Th17/Treg细胞及其它们的主要相关因子IL-17、IL-10、中性粒细胞与哮喘关系的研究进展作一简要综述.

  8. U.S. Global Change Research Program Budget Crosscut

    Data.gov (United States)

    Office of Science and Technology Policy, Executive Office of the President — U.S. Global Change Research Program budget authority for Agency activities in which the primary focus is on:Observations, research, and analysis of climate change...

  9. Use motion games in exercise with children with bronchial asthma

    Directory of Open Access Journals (Sweden)

    Viktoriya Polkovnyk-Markova

    2016-02-01

    Full Text Available Purpose: to analyze the possibility of using moving games in the rehabilitation of children with bronchial asthma. Material & Methods: the modern scientific literature on integrated prevention and treatment of children with asthma. Results: A high frequency of morphological and functional deviations at children with asthma. Classification and examples of mobile games, which can be used for this group of children. Conclusions: the results of modern research that show the effectiveness the use of physical rehabilitation, including moving games.

  10. It’s scary, scary, scary …”: the lived experience of asthma.

    OpenAIRE

    Allen-Collinson, Jacquelyn; Owton, Helen; Siriwardena, Aloysius Niroshan

    2015-01-01

    The research presented here contributes to a developing sociological-phenomenological empirical corpus of literature by addressing the lived experience of asthma in non-élite sports participants and committed exercisers. Despite the prevalence of asthma and exercise-induced asthma/bronchoconstriction, there is a distinct lacuna in terms of qualitative research into living with asthma, and specifically in relation to participation in sports and physical cultures. Here we focus upon the aural d...

  11. Asthma and Therapeutics: Recombinant Therapies in Asthma

    OpenAIRE

    Cockcroft Donald W

    2005-01-01

    Abstract Numerous recombinant therapies are being investigated for the treatment of asthma. This report reviews the current status of several of these novel agents. Anti-immunoglobulin (Ig)E (omalizumab, Xolair) markedly inhibits all aspects of the allergen challenge in subjects who have reduction of free serum IgE to undetectable levels. Several clinical studies in atopic asthma have demonstrated benefit by improved symptoms and lung function and a reduction in corticosteroid requirements. E...

  12. Asthma and obesity

    DEFF Research Database (Denmark)

    Ulrik, Charlotte S

    2016-01-01

    PURPOSE OF REVIEW: Obesity has significant negative impact on asthma control and risk of exacerbations. The purpose of this review is to discuss recent studies evaluating the effects of weight reduction on asthma control in obese adults. RECENT FINDINGS: Clinical studies have shown that weight...... reduction in obese patients is associated with improvements in symptoms, use of controller medication, and asthma-related quality of life together with a reduction in the risk for severe exacerbations. Furthermore, several studies have also revealed improvements in lung function and airway responsiveness...... reduction in obese adults with asthma leads to an overall improvement in asthma control, including airway hyperresponsiveness and inflammation. Weight reduction should be a cornerstone in the management of obese patients with asthma....

  13. Monitoring asthma in childhood

    Directory of Open Access Journals (Sweden)

    Karin C. Lødrup Carlsen

    2015-06-01

    Full Text Available The goal of asthma treatment is to obtain clinical control and reduce future risks to the patient. However, to date there is limited evidence on how to monitor patients with asthma. Childhood asthma introduces specific challenges in terms of deciding what, when, how often, by whom and in whom different assessments of asthma should be performed. The age of the child, the fluctuating course of asthma severity, variability in clinical presentation, exacerbations, comorbidities, socioeconomic and psychosocial factors, and environmental exposures may all influence disease activity and, hence, monitoring strategies. These factors will be addressed in herein. We identified large knowledge gaps in the effects of different monitoring strategies in children with asthma. Studies into monitoring strategies are urgently needed, preferably in collaborative paediatric studies across countries and healthcare systems.

  14. Internet-based self-management in asthma

    NARCIS (Netherlands)

    Meer, Victor van der

    2010-01-01

    This thesis describes the role of internet-based support in the delivery of an asthma self management program. First, the compliance and reliability of home lung function monitoring, one of the key features of asthma self-management, was studied and appeared to be high over a 4-week period. Second,

  15. Underlying chemistry research for the nuclear fuel waste management program

    International Nuclear Information System (INIS)

    This document reviews the underlying chemistry research part of the Canadian Nuclear Fuel Waste Management Program, carried out in the Research Chemistry Branch. This research is concerned with developing the basic chemical knowledge and under-standing required in other parts of the Program. There are four areas of underlying research: Waste Form Chemistry, Solute and Solution Chemistry, Rock-Water-Waste Interactions, and Abatement and Monitoring of Gas-Phase Radionuclides

  16. Latino caregiver experiences with asthma health communication.

    Science.gov (United States)

    Riera, Antonio; Ocasio, Agueda; Tiyyagura, Gunjan; Krumeich, Lauren; Ragins, Kyle; Thomas, Anita; Trevino, Sandra; Vaca, Federico E

    2015-01-01

    In this article, we analyze qualitative data from a purposeful sample of limited English proficiency (LEP) asthma health caregivers. We used ethnically concordant, semistructured, in-depth Spanish-language interviews and a follow-up focus group to explore issues related to communication during pediatric asthma encounters in medical settings. Inductive coding of Spanish transcripts by a bilingual research team was performed until thematic saturation was reached. Several key findings emerged. LEP caregivers encountered significant asthma burdens related to emotional stress, observed physical changes, and communication barriers. Language-discordant communication and the use of ad hoc interpreters were common. This finding is complex, and was influenced by perceptions of interpreter availability, delays in care, feelings of mistrust toward others, and individual emotional responses. Language-concordant education and suitable action plans were valued and desired. We discuss a revealing depiction of the LEP caregiver experience with asthma health communication and recommend areas for further inquiry. PMID:25185159

  17. About the Epidemiology and Genomics Research Program

    Science.gov (United States)

    Epidemiology is the scientific study of the causes and distribution of disease in populations. NCI-funded epidemiology research is conducted through research at institutions in the United States and internationally.

  18. Cooperative research program in coal liquefaction

    Energy Technology Data Exchange (ETDEWEB)

    Huffman, G.P. (ed.)

    1991-01-01

    This Quarterly Report on coal liquefaction research includes discussion in the areas of (1) Iron Based Catalysts for Coal Liquefaction; (2) Exploratory Research on Coal Conversion; (3) Novel Coal Liquefaction Concepts; (4) Novel Catalysts for Coal Liquefaction. (VC)

  19. Overview of EPRI's human factors research program

    International Nuclear Information System (INIS)

    The human factors engineering program in the Nuclear Power Division, EPRI is dedicated to the resolution of man-machine interface problems specific to the nuclear power industry. Particularly emphasis is placed on the capabilities and limitations of the people who operate and maintain the system, the tasks they must perform, and what they need to accomplish those tasks. Six human factors R and D projects are being conducted at the present time. In addition, technical consultation is being furnished to a study area, operator aids, being funded by another program area outside the human factors program area. All of these activities are summarized

  20. Basic mechanisms of asthma.

    OpenAIRE

    Boushey, H A; Fahy, J.V.

    1995-01-01

    Results of studies of the epidemiology, physiology, histopathology, and cell biology of asthma have revised our conception of the disease. Epidemiologic studies have shown asthma to be an important cause of death, suffering, and economic hardship. Physiologic studies have shown that asthma is a chronic illness characterized by persistent bronchial hyperreactivity. Histopathologic studies have shown characteristic changes: epithelial damage, deposition of collagen beneath the basement membrane...

  1. Ketotifen and nocturnal asthma.

    OpenAIRE

    Catterall, J R; Calverley, P M; Power, J T; Shapiro, C M; Douglas, N J; Flenley, D. C.

    1983-01-01

    Patients with asthma often wheeze at night and they also become hypoxic during sleep. To determine whether ketotifen, a drug with sedative properties, is safe for use at night in patients with asthma, we performed a double blind crossover study comparing the effects of a single 1 mg dose of ketotifen and of placebo on arterial oxygen saturation (SaO2), breathing patterns, electroencephalographic (EEG) sleep stage, and overnight change in FEV1 in 10 patients with stable asthma. After taking ke...

  2. Epidemiological Trends in Asthma

    OpenAIRE

    Sears, Malcolm R

    1996-01-01

    Many markers of asthma morbidity have shown substantial increases over the past two decades, including family physician visits, use of anti-asthma medications, emergency room visits and hospital admissions. The reported prevalence of diagnosed asthma and of wheezing has increased, especially in children, with accompanying evidence of increased atopy and increased airway responsiveness. Allergen exposure and parental smoking are significant risk factors for childhood wheezing, whereas the infl...

  3. Programmed Death-1 Antibody Blocks Therapeutic Effects of T-Regulatory Cells in Cockroach Antigen-Induced Allergic Asthma

    OpenAIRE

    McGee, Halvor S; Yagita, Hideo; Shao, Zhifei; Devendra K Agrawal

    2009-01-01

    We recently reported that the adoptive transfer of T-regulatory cells (Tregs) isolated from lung and spleen tissue of green fluorescent protein–transgenic mice reversed airway hyperresponsiveness and airway inflammation. Because Programmed Death-1 (PD-1) is a pivotal receptor regulating effector T-cell activation by Tregs, we evaluated whether PD-1 is involved in the therapeutic effect of naturally occurring Tregs (NTregs) and inducible Tregs (iTregs) in cockroach (CRA)-sensitized and challen...

  4. Network for Translational Research - Cancer Imaging Program

    Science.gov (United States)

    Cooperative agreement (U54) awards to establish Specialized Research Resource Centers that will participate as members of a network of inter-disciplinary, inter-institutional research teams for the purpose of supporting translational research in optical imaging and/or spectroscopy in vivo, with an emphasis on multiple modalities.

  5. Applied atmospheric resources research program in Thailand

    Science.gov (United States)

    Medina, J. G.; Rasmussen, R. M.; Dennis, A. S.; Silverman, B. A.

    1989-08-01

    The Royal Thai Government requested assistance of the United States Agency for International Development for the development and implementation of a more comprehensive scientific approach to the design, operation, and evaluation of Thailand's weather modification program. Upon visiting Thailand, a team of American scientists recommended a 5-year developmental program to improve Thai technical capabilities through training, additional equipment, and a demonstration cloud seed project. The program will test for an increase in rainfall from: (1) warm clouds seeded with hygroscopic agents; and (2) cold clouds seeded for dynamic effects with glaciogenic materials. The field program will be conducted in the Nam Mae Tun River Watershed of western Thailand. The primary response variable is rainfall measured by rain-gauge-adjusted radar. Given equal numbers of warm and cold cloud units and typical operations problems and weather variability, at least four seasons of field experimentation are required.

  6. Asthma: Basic Information

    Science.gov (United States)

    ... physicians' office Health care providers - Medical clinics/physicians' office Health care providers - Other Parents - Home Case Studies Open Airways for Schools Asthma Care Training Wee Wheezers ...

  7. Asthma in Olympians.

    Science.gov (United States)

    Carlsen, Kai-Håkon

    2016-01-01

    High prevalence of asthma has been reported repeatedly among elite athletes, especially among endurance athletes. So many athletes used asthma drugs that the objective demonstration of bronchial hyperresponsiveness was required to obtain approval for their use in international sports until 2012 when the most used inhaled asthma drugs was allowed for free use, but with a maximum dose for inhaled β2-agonists. Several factors contribute to the development of asthma among the Olympians causing airways inflammation and bronchial hyper-responsiveness. PMID:26631837

  8. Asthma among mink workers

    DEFF Research Database (Denmark)

    Grøntved, Berit; Carstensen, Ole; Petersen, Rolf;

    2014-01-01

    We report two cases of asthma among mink workers. The first case is about a mink farmer who had asthma that was difficult to treat. In the medical history there was no clear relation to work, and no conclusive work relation with peak flow monitoring. He had a positive histamine release test to mink...... urine. The second case is about a mink farm worker, who had an asthma attack when handling mink furs. Peak flow monitoring showed a clear relation to this work, but there were no signs of allergy. We conclude that these two cases suggest an increased risk of asthma among mink workers....

  9. Pharmacogenomics of pediatric asthma

    Directory of Open Access Journals (Sweden)

    Gupta Sarika

    2010-01-01

    Full Text Available Context: Asthma is a complex disease with multiple genetic and environmental factors contributing to it. A component of this complexity is a highly variable response to pharmacological therapy. Pharmacogenomics is the study of the role of genetic determinants in the variable response to therapy. A number of examples of possible pharmacogenomic approaches that may prove of value in the management of asthma are discussed below. Evidence Acquisition: A search of PubMed, Google scholar, E-Medicine, BMJ and Mbase was done using the key words "pharmacogenomics of asthma", "pharmacogenomics of β-agonist, glucocorticoids, leukotriene modifiers, theophylline, muscarinic antagonists in asthma". Results: Presently, there are limited examples of gene polymorphism that can influence response to asthma therapy. Polymorphisms that alter response to asthma therapy include Arg16Gly, Gln27Glu, Thr164Ile for β-agonist receptor, polymorphism of glucocorticoid receptor gene, CRHR1 variants and polymorphism of LTC4S, ALOX5. Polymorphic variants of muscarinic receptors, PDE4 and CYP450 gene variants. Conclusion: It was concluded that genetic variation can improve the response to asthma therapy. However, no gene polymorphism has been associated with consistent results in different populations. Therefore, asthma pharmacogenomic studies in different populations with a large number of subjects are required to make possible tailoring the asthma therapy according to the genetic characteristic of individual patient.

  10. Biomarkers in Severe Asthma.

    Science.gov (United States)

    Wan, Xiao Chloe; Woodruff, Prescott G

    2016-08-01

    Biomarkers have been critical for studies of disease pathogenesis and the development of new therapies in severe asthma. In particular, biomarkers of type 2 inflammation have proven valuable for endotyping and targeting new biological agents. Because of these successes in understanding and marking type 2 inflammation, lack of knowledge regarding non-type 2 inflammatory mechanisms in asthma will soon be the major obstacle to the development of new treatments and management strategies in severe asthma. Biomarkers can play a role in these investigations as well by providing insight into the underlying biology in human studies of patients with severe asthma. PMID:27401625

  11. Preconference Educational Research Training Program in Music Education. Final Report.

    Science.gov (United States)

    Petzold, Robert; And Others

    The 1970 Preconference Educational Research Training Program (RTP) provided three 3-day sessions of intensive research training for a total of 160 music educators from across the country. The primary purpose of the RTP activity was to provide music education researchers and users of research with intensive training in three major areas (1)…

  12. Human Research Program Science Management: Overview of Research and Development Activities

    Science.gov (United States)

    Charles, John B.

    2007-01-01

    An overview of research and development activities of NASA's Human Research Science Management Program is presented. The topics include: 1) Human Research Program Goals; 2) Elements and Projects within HRP; 3) Development and Maintenance of Priorities; 4) Acquisition and Evaluation of Research and Technology Proposals; and 5) Annual Reviews

  13. Action Research: Effective Marketing Strategies for a Blended University Program

    Science.gov (United States)

    Cook, Ruth Gannon; Ley, Kathryn

    2008-01-01

    This action research study investigated a marketing plan based on collaboration among a program faculty team and other organizational units for a graduate professional program. From its inception through the second year of operation, program enrollment increased due to the marketing plan based on an effective approach grounded in simple marketing…

  14. Assessment Study of an Undergraduate Research Training Abroad Program

    Science.gov (United States)

    Nieto-Fernandez, Fernando; Race, Kathryn; Quarless, Duncan A.

    2013-01-01

    The Old Westbury Neuroscience International Research Program (OWNIP) encourages undergraduate students from health disparities populations and underrepresented minorities to pursue careers in basic science, biomedical, clinical, and behavioral health research fields. To evaluate this program, several measures were used tracked through an online…

  15. Horonobe underground research program. Research report of 2002 FY investigation

    International Nuclear Information System (INIS)

    Main results of investigation about Horonobe deep underground research center in 2002 FY were reported. It consists of six chapters: introduction, main results, selection of research center area, underground science research, R and D of geological disposal, and the environmental survey and research center on the ground. The research center area at about 3 km north of Horonobe (B1) was selected in the four areas: A, B1, B2 and C on the basis of data, researches in the sky, aboveground and underground and other conditions. The model of geological environment was constructed by physical, geological, surface water supply researches. Development of geological environment monitoring techniques, investigation of long stabilization of geological environment and design of underground facilities are reported. The basic design of preparation of research center was investigated. (S.Y.)

  16. Trends and predictors of asthma costs: results from a 10-year longitudinal study.

    Science.gov (United States)

    Tan, Ngiap Chuan; Nguyen, Hai V; Lye, Weng Kit; Sankari, Usha; Nadkarni, Nivedita V

    2016-03-01

    Research on asthma costs often focuses on estimating average asthma costs. Trends in asthma costs and patterns of medication use, especially for those who have been followed up and under treatment, have received much less attention. This study's objective was to document asthma costs over time for asthma patients who are enrolled in an asthma care programme in Singapore and to identify its predictors, using a 10-year longitudinal dataset.The study population comprised different cohorts of 939 asthma patients entering the programme at different times during 2004-2013. Average asthma costs were estimated and the trends over time examined graphically, within and across patient cohorts. Regression analyses were conducted to examine cost predictors, with a focus on the relationship between risk factors at programme enrolment and subsequent asthma costs.The results indicate that 10-year average annual asthma cost was GBP 341 per patient. The main drivers of costs were asthma medications and consultation fees. Use of combined inhaled corticosteroid/long-acting β-agonist medications increased over time, but this was accompanied by declines in controller drug use, doctor visits and total asthma drug costs. Obesity, smoking and asthma severity were the main predictors of subsequent asthma costs, especially for females. PMID:26647437

  17. The research progress on family management and psychotherapy of childhood asthma%儿童哮喘家庭管理和心理治疗研究进展

    Institute of Scientific and Technical Information of China (English)

    顾希茜(综述); 向莉(审校)

    2014-01-01

    哮喘的高患病率及其反复发作、慢性持续、难以治愈的特点对哮喘儿童生理、心理及其家庭都会产生重要影响。该文一方面通过简述儿童哮喘家庭管理的研究现状及其影响因素,深入了解哮喘家庭管理的必要性;另一方面综述行为疗法、认知疗法、认知行为疗法、放松疗法、家庭心理疗法等目前国内外现有的心理治疗措施,以及上述各种心理疗法的实施效果,以期为制定儿童哮喘综合防治体系及实施研究提供思路。%The childhood asthma is characterized as high morbidity,recurrent attack,chronic persistence and refractoriness. So asthma with these features mentioned above can have important effect on children′s emo-tional and physical development as well as their families. This review sketches the studies of children asthma family management present situation and its influencing factors,and stresses the necessity of asthma family man-agement. Methods of psychotherapy used in our country and abroad and its implementation effect are reviewed, including behavior therapy,cognitive therapy,cognitive behavioral therapy,relaxation therapy,family therapy and other existing psychological treatment,in order that these measures can be conductive to the development of pre-vention methods of pediatric asthma and further researches.

  18. Pharmacogenomics and the research progress of personalized medication in asthma%药物基因组学与哮喘个体化给药研究进展

    Institute of Scientific and Technical Information of China (English)

    雷雪春; 朱黎明; 戴爱国

    2014-01-01

    The main drugs used for asthma include β2 -adrenoceptor agonists , corticosteroids and leukotriene modifiers.Clinical and experi-mental studies found that there are individual differences in patient′s response to asthma drugs.The individual differences is associated with asthma-related genes , while some mutant gene loci can affect the pa-tient′s response to drug.These genes include β2 -adrenergic receptor gene (ADRB2), the glucocorticoid receptor gene (NR3C1), leukotriene synthase ( LTC4 S and ALOX5 ) genes and so on.The article will summa-rize asthma-related pharmacogenomics research , hoping to provide help for the future realization of personalized medicine for asthma.%治疗哮喘的主要药物包括β2-肾上腺素受体激动剂、糖皮质激素和白三烯调节剂。患者对哮喘药物的反应存在个体差异,这种差异与哮喘相关基因有关。基因某些位点的突变,影响患者对药物的反应性,这些基因包括β2-肾上腺素受体基因( ADRB2)、糖皮质激素受体基因( NR3C1)及白三烯合成酶(LTC4S和ALOX5)基因等。本文对哮喘相关的药物基因组学研究进行综述,希望为哮喘的个体化治疗提供帮助。

  19. SKB's program for societal research 2004-2011. An evaluation

    International Nuclear Information System (INIS)

    This evaluation of the program of societal research that SKB conducted the years 2004-2011 has been performed on behalf of Swedish Nuclear Fuel and Waste Management Company (SKB). The review has focused on answers to a series of questions as follows: General questions - Why was a program started? - What was SKB's purpose with the program? - Does the result mean that the objective has been achieved? - Has the program had effects (positive or negative) that were not anticipated when the purpose was formulated? - Strengths and weaknesses of the program? Questions about the implementation - How did announcement and selection procedures work? - Which forms were used for reporting results from the research projects? Questions about the continued investment in societal research - Are there such needs? - In that case, is it in SKB's interest to contribute financially to such research? - What forms might be appropriate if SKB sees interest to contribute financially to such research?

  20. Risk of Asthma from Cesarean Delivery Depends on Membrane Rupture

    DEFF Research Database (Denmark)

    Sevelsted, Astrid; Stokholm, Jakob; Bisgaard, Hans

    2016-01-01

    weight, gestational age, multiple births, parity, and maternal factors (age, smoking/antibiotics during pregnancy, employment status, and asthma). RESULTS: In the Copenhagen Prospective Studies on Asthma in Childhood2000 cohort, the adjusted hazard ratio for asthma was increased by cesarean delivery......OBJECTIVE: To assess our prospective mother-child cohort and the national registry data to analyze the risk of asthma by delivery mode and whether cesarean delivery before or after membrane rupture affects this risk differently. STUDY DESIGN: The Copenhagen Prospective Studies on Asthma...... in Childhood2000 is a high-risk birth cohort of 411 Danish children. Asthma was diagnosed prospectively by physicians at the research site, and associations with cesarean delivery were investigated using Cox proportional hazard models. From the Danish national prospective registry we included data from 1997...

  1. Asthma, allergy, and respiratory symptoms in centenarians living in Poland.

    Science.gov (United States)

    Mossakowska, M; Pawlinska-Chmara, R; Broczek, K M

    2008-12-01

    According to National Census, there were 1541 people over the age of 100 years (centenarians) in Poland, in 2002, including 1215 females and 326 males. The aim of the present study was to assess the prevalence of asthma, allergy, and respiratory symptoms in centenarians included in the Polish Centenarians Program, POLSTU 2001, conducted between 2001 and 2004. The study group consisted of 301 subjects including 258 females and 43 males. Research data were gathered in a questionnaire designed exclusively for the study, completed by the interviewer during meetings with the subjects and their families. According to the medical history reported by the subjects, 10 persons (3.3%) suffered from asthma and 41 (13.6%) from allergy. There were no subjects with childhood onset asthma. Allergy to food and medicinal products was the most prevalent. One in four centenarians reported dyspnea and one in eight complained of cough. When analyzed in relation to gender, cough was more prevalent in males, which might have been related to cigarette smoking. Respiratory disorders are frequent in elderly populations, but symptoms may be underreported, especially in the situation of coexisting medical problems. Moreover, it might be difficult to perform full diagnostic procedures in the very elderly due to disability, cognitive impairment, and technical problems. Thus, medical care for the aged should be based on thorough medical evaluation supported by the medical history and reliable information on physician-diagnosed diseases.

  2. Infectious Disease Clinical Research Program (IDCRP)

    Data.gov (United States)

    Federal Laboratory Consortium — Our mission is to conduct infectious disease clinical research of importance to the military through a unique, adaptive, and collaborative network, to inform health...

  3. Laboratory Directed Research and Development Program: FY 2015 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    SLAC,

    2016-04-04

    The Department of Energy (DOE) and the SLAC National Accelerator Laboratory (SLAC) encourage innovation, creativity, originality and quality to maintain the Laboratory’s research activities and staff at the forefront of science and technology. To further advance its scientific research capabilities, the Laboratory allocates a portion of its funds for the Laboratory Directed Research and Development (LDRD) program. With DOE guidance, the LDRD program enables SLAC scientists to make rapid and significant contributions that seed new strategies for solving important national science and technology problems. The LDRD program is conducted using existing research facilities.

  4. Control of asthma in real life: still a valuable goal?

    Directory of Open Access Journals (Sweden)

    Andriana I. Papaioannou

    2015-06-01

    Full Text Available Although studies show that control of asthma can be achieved in the majority of patients, surveys repeatedly show that this is not the case in real life. Important measures to implement in order to achieve asthma control are trained healthcare professionals, a good patient–doctor relationship, patient education, avoidance of exposure to triggers, personalised management and adherence to treatment. These measures help the majority of asthma patients but have not yet been widely implemented and there should be a concerted action for their implementation. Moreover, further and focused research is needed in severe/refractory asthma.

  5. Acceptable respiratory protection program and LASL respirator research

    International Nuclear Information System (INIS)

    A short history is presented on the LASL Respiratory Protection Training Programs. Then a discussion is given on the major points of an acceptable respiratory protection program utilizing the points required by the Occupational, Safety, and Health Administration (OSHA) Regulation 29 CFR 1910.134. Contributions to respirator research are reviewed. Discussion is presented under the following section headings: program administration; respirator selection; respirator use; fitting and training; respirator maintenance; medical clearance and surveillance; special problems; program evaluation; and documentation

  6. Nutrition and Asthma

    Directory of Open Access Journals (Sweden)

    Gupta K

    2007-01-01

    Full Text Available Increase in the asthma prevalence in many countries over the recent decades, highlights the need for a greater understanding of the risk factors for asthma. Be-cause asthma is the result of interaction between genetic and environmental fac-tors, increasing prevalence is certainly the result of changes in environmental fac-tors because of process of wesernization. That is the reason for higher prevalence in countries where a traditional to a westernized lifestyle occurred earlier. This increasing prevalence has affected both rural and urban communities, suggesting that local environmental factors such as exposure to allergens or industrial air pol-lutions are not the sole cause. In the last few years, nutrition has represented an important conditioning factor of many cardiovascular, gastrointestinal and chronic pulmonary diseases. So it has been hypothesized that dietary constituents influence the immune system and thus, may also be actively involved in the onset of asthma and other allergic diseases. Dietary constituents can play beneficial as well as det-rimental role in asthma. The possible role of diet in the development of asthma can be described as follows: first, a food allergen can cause asthma. Second, there is role of breast-feeding for prevention of asthma later in life. Third, a low intake of antioxidative dietary constituents might be a risk factor for asthma. Moreover, role of cations such as sodium, potassium and magnesium has been described in development of asthma. Finally, intake of fatty acids specially the role of omega-3 and omega-6 fatty acids play important role in cause of asthma.

  7. ANSTO - Program of Research 1994-1995

    International Nuclear Information System (INIS)

    The report outlines the planned research and development activities for 1994-1995 in five major research units: Advanced Materials, Applications of Nuclear Physics, Biomedicine and Health, Environmental Sciences and the Safety and Reliability Centre. A list of recent publication originated from ANSTO's scientific and engineering activities is also included. ills

  8. ANSTO - Program of Research 1994-1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    The report outlines the planned research and development activities for 1994-1995 in five major research units: Advanced Materials, Applications of Nuclear Physics, Biomedicine and Health, Environmental Sciences and the Safety and Reliability Centre. A list of recent publication originated from ANSTO`s scientific and engineering activities is also included. ills.

  9. Fiscal year 1978 program of research

    Energy Technology Data Exchange (ETDEWEB)

    Linville, B. (ed.)

    1978-01-01

    The responsibilities of the Bartlesville Energy Research Center in the areas of advanced research on coal, enhanced oil recovery, drilling and offshore technology, product characterization, enhanced gas recovery, waste oil recycling, and alternative fuels are briefly reviewed and the progress made indicated. (JSR)

  10. Programs of the Office of Energy Research

    International Nuclear Information System (INIS)

    The Office of Energy Research sponsors long-term research in certain fundamental areas and in technical areas associated with energy resources, production, use, and resulting health and environmental effects. This document describes these activities, including recent accomplishments, types of facilities, and gives some impacts on energy, science, and scientific manpower development. The document is intended to respond to the many requests from diverse communities --- such as government, education, and public and private research --- for a summary of the types of research sponsored by the Department of Energy's Office of Energy Research. This is important since the Office relies to a considerable extent on unsolicited proposals from capable university and industrial groups, self-motivated interested individuals, and organizations that may wish to use the Department's extensive facilities and resources. By describing our activities and facilities, we hope not only to inform, but to also encourage interest and participation

  11. Epigenetics: The New Frontier in the Landscape of Asthma

    Directory of Open Access Journals (Sweden)

    Bharti Chogtu

    2016-01-01

    Full Text Available Over the years, on a global scale, asthma has continued to remain one of the leading causes of morbidity, irrespective of age, sex, or social bearings. This is despite the prevalence of varied therapeutic options to counter the pathogenesis of asthma. Asthma, as a disease per se, is a very complex one. Scientists all over the world have been trying to obtain a lucid understanding of the machinations behind asthma. This has led to many theories and conjectures. However, none of the scientific disciplines have been able to provide the missing links in the chain of asthma pathogenesis. This was until epigenetics stepped into the picture. Though epigenetic research in asthma is in its nascent stages, it has led to very exciting results, especially with regard to explaining the massive influence of environment on development of asthma and its varied phenotypes. However, there remains a lot of work to be done, especially with regard to understanding how the interactions between immune system, epigenome, and environment lead to asthma. But introduction of epigenetics has infused a fresh lease of life in research into asthma and the mood among the scientific community is that of cautious optimism.

  12. 77 FR 40590 - Applications for New Awards: Disability and Rehabilitation Research Projects and Centers Program...

    Science.gov (United States)

    2012-07-10

    ... Applications for New Awards: Disability and Rehabilitation Research Projects and Centers Program; Disability... Rehabilitation Research Projects and Centers Program--Disability and Rehabilitation Research Projects--Burn Model... Rehabilitation Research Projects and Centers Program-- Disability and Rehabilitation Research...

  13. National Geospatial-Intelligence Agency Academic Research Program

    Science.gov (United States)

    Loomer, S. A.

    2004-12-01

    "Know the Earth.Show the Way." In fulfillment of its vision, the National Geospatial-Intelligence Agency (NGA) provides geospatial intelligence in all its forms and from whatever source-imagery, imagery intelligence, and geospatial data and information-to ensure the knowledge foundation for planning, decision, and action. To achieve this, NGA conducts a multi-disciplinary program of basic research in geospatial intelligence topics through grants and fellowships to the leading investigators, research universities, and colleges of the nation. This research provides the fundamental science support to NGA's applied and advanced research programs. The major components of the NGA Academic Research Program (NARP) are: - NGA University Research Initiatives (NURI): Three-year basic research grants awarded competitively to the best investigators across the US academic community. Topics are selected to provide the scientific basis for advanced and applied research in NGA core disciplines. - Historically Black College and University - Minority Institution Research Initiatives (HBCU-MI): Two-year basic research grants awarded competitively to the best investigators at Historically Black Colleges and Universities, and Minority Institutions across the US academic community. - Director of Central Intelligence Post-Doctoral Research Fellowships: Fellowships providing access to advanced research in science and technology applicable to the intelligence community's mission. The program provides a pool of researchers to support future intelligence community needs and develops long-term relationships with researchers as they move into career positions. This paper provides information about the NGA Academic Research Program, the projects it supports and how other researchers and institutions can apply for grants under the program.

  14. Exploratory Technology Research Program for electrochemical energy storage

    Science.gov (United States)

    Kinoshita, Kim

    1994-09-01

    The U.S. Department of Energy's Office of Propulsion Systems provides support for an Electrochemical Energy Storage Program, that includes research and development (R&D) on advanced rechargeable batteries and fuel cells. A major goal of this program is to develop electrochemical power sources suitable for application in electric vehicles (EV's). The program centers on advanced systems that offer the potential for high performance and low life-cycle costs, both of which are necessary to permit significant penetration into commercial markets. The DOE Electrochemical Energy Storage Program is divided into two projects: the Electric Vehicle Advanced Battery Systems (EVABS) Development Program and the Exploratory Technology Research (ETR) Program. The EVABS Program management responsibility has been assigned to Sandia National Laboratories (SNL); Lawrence Berkeley Laboratory (LBL) is responsible for management of the ETR Program. The EVABS and ETR Programs include an integrated matrix of R&D efforts designed to advance progress on selected candidate electrochemical systems. The United States Advanced Battery Consortium (USABC), a tripartite undertaking between DOE, the U.S. automobile manufacturers and the Electric Power Research Institute (EPRI), was formed in 1991 to accelerate the development of advanced batteries for consumer EV's. The role of the FIR Program is to perform supporting research on the advanced battery systems under development by the USABC and EVABS Program, and to evaluate new systems with potentially superior performance, durability and/or cost characteristics. The specific goal of the ETR Program is to identify the most promising electrochemical technologies and transfer them to the USABC, the battery industry and/or the EVABS Program for further development and scale-up. This report summarizes the research, financial and management activities relevant to the ETR Program in CY 1993.

  15. The NASA computer science research program plan

    Science.gov (United States)

    1983-01-01

    A taxonomy of computer science is included, one state of the art of each of the major computer science categories is summarized. A functional breakdown of NASA programs under Aeronautics R and D, space R and T, and institutional support is also included. These areas were assessed against the computer science categories. Concurrent processing, highly reliable computing, and information management are identified.

  16. Concepts of Research Methods and Statistics Used in Program Evaluation

    Directory of Open Access Journals (Sweden)

    Raluca Antonie (GÂRBOAN

    2009-06-01

    Full Text Available This paper introduces aspects related tothe relation between Evaluation on the oneside and Research methods and Statistics onthe other side. Because of the interdisciplinaryprofile of program evaluation as a theoreticaland practical field, sometimes the importanceof using the appropriate research methods andthe adequate statistical methods is regarded ashaving a secondary importance. Based on our ownobservations and on some other assessments, weare able to state that the use of research methodsand of statistical methods should be at the core of program evaluation.

  17. Fruits Program Area Research Planning and Prioritization: Background Analysis

    OpenAIRE

    Pabuayon, Isabelita

    2000-01-01

    This study addresses the Fruits Program Area research allocation concerns. It provides a background analysis focusing on the fruits industry profile, domestic and export potentials, supply constraints, role of public and private sector R&D, review of past agricultural research, technologies generated by the R&D program, constraints to and consequences of technology adoption, and the strengths and weaknesses in the institutional structure of research and extension linkage. Additionally, it pro...

  18. Risk factors for death in patients with severe asthma

    Directory of Open Access Journals (Sweden)

    Andréia Guedes Oliva Fernandes

    2014-08-01

    Full Text Available OBJECTIVE: To identify risk factors for death among patients with severe asthma. METHODS: This was a nested case-control study. Among the patients with severe asthma treated between December of 2002 and December of 2010 at the Central Referral Outpatient Clinic of the Bahia State Asthma Control Program, in the city of Salvador, Brazil, we selected all those who died, as well as selecting other patients with severe asthma to be used as controls (at a ratio of 1:4. Data were collected from the medical charts of the patients, home visit reports, and death certificates. RESULTS: We selected 58 cases of deaths and 232 control cases. Most of the deaths were attributed to respiratory causes and occurred within a health care facility. Advanced age, unemployment, rhinitis, symptoms of gastroesophageal reflux disease, long-standing asthma, and persistent airflow obstruction were common features in both groups. Multivariate analysis showed that male gender, FEV1 pre-bronchodilator < 60% of predicted, and the lack of control of asthma symptoms were significantly and independently associated with mortality in this sample of patients with severe asthma. CONCLUSIONS: In this cohort of outpatients with severe asthma, the deaths occurred predominantly due to respiratory causes and within a health care facility. Lack of asthma control and male gender were risk factors for mortality.

  19. IAEA Co-ordinated Research Program (CRP)

    International Nuclear Information System (INIS)

    The Coordinated Research Project is a topical collection of research agreements and contracts. The research contracts are awarded with financial support of about 10-20% of the total contract cost. Among the activities of the project is the organization of consultant group meetings and workshops involving several international experts and representatives of users and developers of border radiation monitoring equipment. The project also supports in coordinating the development of equipment and techniques for up-to-date border monitoring and in establishing of a process for providing nuclear forensics support to member states

  20. Management program on radioactive wastes in research

    International Nuclear Information System (INIS)

    This document has the objective to orient and advise the researchers to practice a safety management of radioactive wastes in each research laboratory, based upon the technical norms of the Brazilian Nuclear Energy Commission and the recommendations of the International Atomic Energy Agency. Additionally, basic information on the main radioisotopes used in research are presented, including the processes used for production of radioisotopes, methods for radiation detection, range of alpha and beta particles, background radiation, as well as principles on radioprotection and biological effects of radiation

  1. Laboratory Directed Research and Development Program FY 2006 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sjoreen, Terrence P [ORNL

    2007-04-01

    The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the US Departmental of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2006. The associated FY 2006 ORNL LDRD Self-Assessment (ORNL/PPA-2007/2) provides financial data about the FY 2006 projects and an internal evaluation of the program's management process.

  2. Asthma and Therapeutics: Recombinant Therapies in Asthma

    Directory of Open Access Journals (Sweden)

    Cockcroft Donald W

    2005-03-01

    Full Text Available Abstract Numerous recombinant therapies are being investigated for the treatment of asthma. This report reviews the current status of several of these novel agents. Anti-immunoglobulin (IgE (omalizumab, Xolair markedly inhibits all aspects of the allergen challenge in subjects who have reduction of free serum IgE to undetectable levels. Several clinical studies in atopic asthma have demonstrated benefit by improved symptoms and lung function and a reduction in corticosteroid requirements. Early use in atopic asthmatics may be even more effective. Several approaches target interleukin (IL-4. Soluble IL-4 receptor has been shown to effectively replace inhaled corticosteroid; further studies are under way. Recombinant anti-IL-5 and recombinant IL-12 inhibit blood and sputum eosinophils and allergen-induced eosinophilia without any effect on airway responsiveness, allergen-induced airway responses, or allergen-induced airway hyperresponsiveness. Efalizumab, a recombinant antibody that inhibits lymphocyte trafficking, is effective in psoriasis. A bronchoprovocation study showed a reduction in allergen-induced late asthmatic response and allergen-induced eosinophilia, which suggests that it should be effective in clinical asthma. These exciting novel therapies provide not only promise of new therapies for asthma but also valuable tools for investigation of asthma mechanisms.

  3. Karlsruhe Nuclear Research Center. Research and development program 1992

    International Nuclear Information System (INIS)

    The KfK R and D activities are classified by ten point-of-main-effort projects: 1) low-pollution/low-waste methods, 2) environmental energy and mass transfers, 3) nuclear fusion, 4) nuclear saftey research, 5) radioactive waste management, 6) superconduction, 7) microtechnics, 8) materials handling, 9) materials and interfaces, 10) basic physical research. (orig.)

  4. So You Have Asthma

    Science.gov (United States)

    ... the night every night or competing in the Olympics. In other words, you should be able to live a normal active life! The following list shows what your life could be like if your asthma were controlled: As a rule, you should have: • Few, if any, asthma symptoms • ...

  5. Asthma in childhood.

    Science.gov (United States)

    de Benedictis, Fernando Maria; Attanasi, Marina

    2016-03-01

    Several topics on childhood asthma were addressed in the Paediatric Clinical Year in Review session at the 2015 European Respiratory Society International Congress. With regard to the relationship between lower respiratory tract infections and asthma, it emerges that is the number of respiratory episodes in the first years of life, but not the particular viral trigger, to be associated with later asthma development. Understanding which characteristics of individual patients are associated with an increased risk for asthma exacerbation is a critical step to implement strategies preventing these seasonal events. Recent data suggest the possibility that exhaled volatile organic compounds may qualify as biomarkers in detecting early signs of asthma. Adding information of exhaled volatile organic compounds and expression of inflammation genes to a clinical tool significantly improves asthma prediction in preschool wheezy children. Personal communication with children and adolescents is likely more important than the tools actually used for monitoring asthma. Systemic corticosteroids do not affect the long-term prognosis in children with first viral-induced wheezing episode and should be used cautiously during acute episodes. Finally, stress and a polymorphism upstream of a specific gene are both associated with reduced bronchodilator response in children with asthma.

  6. Asthma in childhood

    Directory of Open Access Journals (Sweden)

    Fernando Maria de Benedictis

    2016-03-01

    Full Text Available Several topics on childhood asthma were addressed in the Paediatric Clinical Year in Review session at the 2015 European Respiratory Society International Congress. With regard to the relationship between lower respiratory tract infections and asthma, it emerges that is the number of respiratory episodes in the first years of life, but not the particular viral trigger, to be associated with later asthma development. Understanding which characteristics of individual patients are associated with an increased risk for asthma exacerbation is a critical step to implement strategies preventing these seasonal events. Recent data suggest the possibility that exhaled volatile organic compounds may qualify as biomarkers in detecting early signs of asthma. Adding information of exhaled volatile organic compounds and expression of inflammation genes to a clinical tool significantly improves asthma prediction in preschool wheezy children. Personal communication with children and adolescents is likely more important than the tools actually used for monitoring asthma. Systemic corticosteroids do not affect the long-term prognosis in children with first viral-induced wheezing episode and should be used cautiously during acute episodes. Finally, stress and a polymorphism upstream of a specific gene are both associated with reduced bronchodilator response in children with asthma.

  7. What Is Asthma?

    Science.gov (United States)

    ... that it is a combination of your family history and your environment. There is no cure for asthma. Once you ... administrators with information, education and resources to incorporate environmental management into clinical practices and standards of care for asthma patients. Top ...

  8. Possible research program on a large scale nuclear pressure vessel

    International Nuclear Information System (INIS)

    The nuclear pressure vessel structural integrity is actually one of the main items in the nuclear plants safety field. An international study group aimed at investigating the feasibility of a ''possible research program'' on a scale 1:1 LWR pressure vessel. This report presents the study group's work. The different research programs carried out or being carried out in various countries of the European Community are presented (phase I of the study). The main characteristics of the vessel considered for the program and an evaluation of activities required for making them available are listed. Research topic priorities from the different interested countries are summarized in tables (phase 2); a critical review by the study group of the topic is presented. Then, proposals for possible experimental programs and combination of these programs are presented, only as examples of possible useful research activities. The documents pertaining to the results of phase I inquiry performed by the study group are reported in the appendix

  9. Advances in Pediatric Asthma in 2013: Coordinating Asthma Care

    OpenAIRE

    Szefler, Stanley J.

    2014-01-01

    Last year’s Advances in Pediatric Asthma: Moving Toward Asthma Prevention concluded that: “We are well on our way to creating a pathway around wellness in asthma care and also to utilize new tools to predict the risk for asthma and take steps to not only prevent asthma exacerbations but also to prevent the early manifestations of the disease and thus prevent its evolution to severe asthma.” This year’s summary will focus on recent advances in pediatric asthma on pre- and postnatal factors alt...

  10. A research Program in Elementary Particle Physics

    Energy Technology Data Exchange (ETDEWEB)

    Sobel, Henry; Molzon, William; Lankford, Andrew; Taffard, Anyes; Whiteson, Daniel; Kirkby, David

    2013-07-25

    Work is reported in: Neutrino Physics, Cosmic Rays and Elementary Particles; Particle Physics and Charged Lepton Flavor Violation; Research in Collider Physics; Dark Energy Studies with BOSS and LSST.

  11. Integrating Research into the MDE Program.

    Science.gov (United States)

    Sanders, Lester E.; Lynd, Robert

    1982-01-01

    Examines a simulation approach to teaching selected research concepts to marketing and distributive education students and to applying these concepts to advertising layout, broadcast media advertising, retail selling, and wholesaling. (CT)

  12. Interleukin 13 and Interleukin 4 Receptor-alpha Polymorphisms in Rhinitis and Asthma

    NARCIS (Netherlands)

    Bottema, Renske W. B.; Nolte, Ilja M.; Howard, Timothy D.; Koppelman, Gerard H.; Dubois, Anthony E. J.; de Meer, Gea; Kerkhof, Marjan; Bleecker, Eugene R.; Meyers, Deborah A.; Postma, Dirkje S.

    2010-01-01

    Background: Asthma and rhinitis may represent two manifestations of the same airway disease. Genetic research can increase our understanding of their common or distinct pathogenesis. IL13 and IL4R polymorphisms are associated with asthma and show gene-gene interaction in asthma. Their role in rhinit

  13. Compliance and noncompliance in asthma.

    Science.gov (United States)

    Kaiser, Harold B

    2007-01-01

    Compliance and noncompliance are big issues in asthma management. It has been well established that compliant patients experience less exacerbations than less compliant patients and that compliance rates often are <50%. The reasons for noncompliance are multiple and complex and not always clearly understood. Methods proposed to improve compliance include patient education, more partnership care, less frequent dosing, simple schedules, diaries, etc. Less dosing and simple schedules are most effective. It is difficult to improve compliance overall and despite extensive research and efforts, rates of compliance remain low. Noncompliance in asthma management is a fact of life and no single compliance-improving strategy probably will be as effective as a good physician-patient relationship. PMID:18034967

  14. The second workshop of neutron science research program

    Energy Technology Data Exchange (ETDEWEB)

    Yasuda, Hideshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Tone, Tatsuzo [eds.

    1997-11-01

    The Japan Atomic Energy Research Institute(JAERI) has been proposing the Neutron Science Research Program to explore a broad range of basic research and the nuclear technology including actinide transmutation with use of powerful spallation neutron sources. For this purpose, the JAERI is conducting the research and development of an intense proton linac, the development of targets, as well as the conceptual design study of experimental facilities required for applications of spallation neutrons and secondary particle beams. The Special Task Force for Neutron Science Initiative was established in May 1996 to promote aggressively and systematically the Neutron Science Research Program. The second workshop on neutron science research program was held at the JAERI Tokai Research Establishment on 13 and 14 March 1997 for the purpose of discussing the results obtained since the first workshop in March 1996. The 27 of the presented papers are indexed individually. (J.P.N.)

  15. Teacher Research Experience Programs = Increase in Student Achievement

    Science.gov (United States)

    Dubner, J.

    2010-12-01

    Columbia University's Summer Research Program for Science Teachers (SRP), founded in 1990, is one of the largest, best known university-based professional development programs for science teachers in the U.S. The program’s basic premise is simple: teachers cannot effectively teach science if they have not experienced it firsthand. For eight weeks in each of two consecutive summers, teachers participate as a member of a research team, led by a member of Columbia University’s research faculty. In addition to the laboratory experience, all teachers meet as a group one day each week during the summer for a series of pedagogical activities. A unique quality of the Summer Research Program is its focus on objective assessment of its impact on attitudes and instructional practices of participating teachers, on the performance of these teachers in their mentors’ laboratories, and most importantly, on the impact of their participation in the program on student interest and performance in science. SRP uses pass rate on the New York State Regents standardized science examinations as an objective measure of student achievement. SRP's data is the first scientific evidence of a connection between a research experience for teachers program and gains in student achievement. As a result of the research, findings were published in Science Magazine. The author will present an overview of Columbia's teacher research program and the results of the published program evaluation.

  16. Lewis' Educational and Research Collaborative Intership Program Grant Closeout Report

    Science.gov (United States)

    2003-01-01

    The Lewis' Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships and 10 or 12-week fellowships for undergraduate/graduate students and secondary school teachers. Approximately 130 interns are selected to participate in this program each year and begin arriving the second week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, lectures and short courses. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds.

  17. Fertility outcomes in asthma

    DEFF Research Database (Denmark)

    Gade, Elisabeth Juul; Thomsen, Simon Francis; Lindenberg, Svend;

    2016-01-01

    Evidence is increasing of an association between asthma and aspects of female reproduction. However, current knowledge is limited and furthermore relies on questionnaire studies or small populations. In a prospective observational cohort study to investigate whether time to pregnancy, the number...... of fertility treatments, and the number of successful pregnancies differ significantly between women with unexplained infertility with and without asthma.245 women with unexplained infertility (aged 23-45 years) underwent questionnaires and asthma and allergy testing while undergoing fertility treatment. 96...... women entering the study had either a former doctor's diagnosis of asthma or were diagnosed with asthma when included. After inclusion they were followed for a minimum of 12 months in fertility treatment, until they had a successful pregnancy, stopped treatment, or the observation ended.The likelihood...

  18. [Distinguishing asthma from COPD].

    Science.gov (United States)

    Ohara, Kouhei; Samukawa, Takuya; Inoue, Hiromasa

    2016-05-01

    Asthma and chronic obstructive pulmonary disease (COPD) are major public health burdens. Asthma is characterized by airway inflammation, airway narrowing with reversibility, and hyperresponsiveness of airways. COPD has been associated with smoking and exposure to environmental fumes, which typically characterized by persistent airflow limitation and chronic inflammation of the airways. These differences are most apparent when young non-smoker with asthma and older smokers with COPD are compared. However, it would be difficult to differentiate asthma from COPD, especially in elderly who currently smoke or have a significant history of smoking. Furthermore, some patients exhibit characteristics of both diseases, this may represent a phenotype known as asthma-COPD overlap syndrome (ACOS). Therefore, the precise understanding of these diseases is important.

  19. Action Research in EdD Programs in Educational Leadership

    Science.gov (United States)

    Osterman, Karen; Furman, Gail; Sernak, Kathleen

    2014-01-01

    This exploratory study gathered information about the use of action research within doctor of education programs in educational leadership and explored faculty understanding of and perspectives on action research. Survey data established that action research is used infrequently to meet dissertation requirements. Contributing factors include lack…

  20. Human Genome Program Report. Part 2, 1996 Research Abstracts

    Science.gov (United States)

    1997-11-01

    This report contains Part 2 of a two-part report to reflect research and progress in the US Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 2 consists of 1996 research abstracts. Attention is focused on the following: sequencing; mapping; informatics; ethical, legal, and social issues; infrastructure; and small business innovation research.

  1. Human genome program report. Part 2, 1996 research abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    This report contains Part 2 of a two-part report to reflect research and progress in the US Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 2 consists of 1996 research abstracts. Attention is focused on the following: sequencing; mapping; informatics; ethical, legal, and social issues; infrastructure; and small business innovation research.

  2. 30 CFR 402.6 - Water-Resources Research Program.

    Science.gov (United States)

    2010-07-01

    ... governments for research concerning any aspect of a water-resource related problem deemed to be in the... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Water-Resources Research Program. 402.6 Section 402.6 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH...

  3. Emerging corticosteroid agonists for the treatment of asthma

    DEFF Research Database (Denmark)

    Westergaard, Christian G; Porsbjerg, Celeste; Backer, Vibeke

    2015-01-01

    on other pathological pathways, research in GRAs for asthma is sparse. However, a few promising agents acting selectively on the GR are currently under investigation and may reach approval for asthma treatment. These drugs exhibit improved pharmacodynamic properties due to selectivity in the mechanism...

  4. Psychosocial Factors and Behavioral Medicine Interventions in Asthma

    Science.gov (United States)

    Ritz, Thomas; Meuret, Alicia E.; Trueba, Ana F.; Fritzsche, Anja; von Leupoldt, Andreas

    2013-01-01

    Objective: This review examines the evidence for psychosocial influences in asthma and behavioral medicine approaches to its treatment. Method: We conducted a systematic review of the literature on psychosocial influences and the evidence for behavioral interventions in asthma with a focus on research in the past 10 years and clinical trials.…

  5. Factors associated with asthma control.

    NARCIS (Netherlands)

    Vries, M.P. de; Bemt, E.A.J.M. van den; Lince, S.; Muris, J.W.M.; Thoonen, B.P.A.; Schayck, C.P. van

    2005-01-01

    The aim of this study was to evaluate which factors are associated with asthma control experienced by asthma patients. In a cross-sectional study patients aged 16-60 years with mild to moderate asthma were selected. The influence of the following factors on asthma control was studied in a multivaria

  6. Asthma control: Patient and environment

    NARCIS (Netherlands)

    L.H.M. Rijssenbeek-Nouwens

    2015-01-01

    Control of asthma, the goal of asthma treatment, seems hard to obtain. However, it is largely unknown why control of asthma remains difficult in many patients in spite of available powerful medication. In this thesis we studied non-pharmacological factors influencing asthma control: patient related

  7. Development of the Stochastic Lung Model for Asthma

    International Nuclear Information System (INIS)

    Complete text of publication follows. The Stochastic Lung Model is a state-of-the-art tool for the investigation of the health impact of atmospheric aerosols. This model has already been tested and applied to calculate the deposition fractions of aerosols in different regions of the human respiratory tract. The health effects of inhaled aerosols may strongly depend on the distribution of deposition within the respiratory tract. In the current study three Asthma Models have been incorporated into the Stochastic Lung Deposition Code. A common new feature of these models is that the breathing cycle may be asymmetric. It means that the inspiration time, the expiration time and the two breath hold times are independent. And the code can simulate the mucus blockage, too. The main characteristics of the models are the followings: a) ASTHMA MODEL I: One input bronchial asthma factor is applied for the whole tracheobronchial region. The code multiplies all tracheobroncial diameters with this single value. b) ASTHMA MODEL II: Bronchial asthma factors have to be given for each bronchial generation as input data (21 values). The program multiplies the diameter of bronchi with these factors. c) ASTHMA MODEL III: Here, only the range of bronchial asthma factors are presented as input data and the code selects randomly the exact factors in pre-described airway generations. In this case the stochastic character appears in the Asthma Model, as well. As an example, Figure 1 shows the deposition fractions in the tracheobronchial and acinar regions of the human lung in the case of healthy and asthmatic adults at sitting breathing conditions as a function of particle size computed by Asthma Model I where the bronchial asthma factor was 30%. These models have been tested and compared for different types of asthma at various breathing conditions and in a wide range of particle sizes. The distribution of deposition in the characteristic regions of the respiratory tract have been computed

  8. Research progress of stress and countermeasures in caregivers of asthma child%哮喘儿童照顾者压力与对策的研究进展

    Institute of Scientific and Technical Information of China (English)

    张显珍; 位珍珍; 侯小妮; 段红梅

    2016-01-01

    Recently,the incidence trend of childhood asthma presented climbing.Because of the long course of disease,recurrent attacks and no cure,asthma brought negative impacts on psychology and physiology in asthma children,and certain burden in caregivers and their family.This article will summarize the research status of national and international literatures and its nursing countermeasures,so as to provide theory for further research and nursing practice.%近年来儿童哮喘的患病率有上升趋势,由于其疾病本身病程漫长、反复发作、不可治愈的特点,不仅对哮喘儿童心理、生理产生负面影响,而且对其照顾者及家庭也带来一定的负担。本文通过综述哮喘儿童照顾者的压力及其产生原因,分析目前国内外相关文献的研究现状及其相应的护理干预措施,以期为日后相关研究及护理实践提供理论依据。

  9. Asthma and chronic obstructive pulmonary disease overlap: asthmatic chronic obstructive pulmonary disease or chronic obstructive asthma?

    Science.gov (United States)

    Slats, Annelies; Taube, Christian

    2016-02-01

    Asthma and chronic obstructive pulmonary disease (COPD) are different disease entities. They are both clinical diagnoses, with diagnostic tools to discriminate between one another. However, especially in older patients (>55 years) it seems more difficult to differentiate between asthma and COPD. This has led to the definition of a new phenotype called asthma COPD overlap syndrome (ACOS). However, our understanding of ACOS is at a very preliminary stage, as most research has involved subjects with existing diagnoses of asthma or COPD from studies with different definitions for ACOS. This has led to different and sometimes opposing results between studies on several features of ACOS, also depending on the comparison with COPD alone, asthma alone or both, which are summarized in this review.We suggest not using the term ACOS for a patient with features of both asthma and COPD, but to describe a patient with chronic obstructive airway disease as completely as possible, with regard to characteristics that determine treatment response (e.g. eosinophilic inflammation) and prognosis (such as smoking status, exacerbation rate, fixed airflow limitation, hyperresponsiveness, comorbidities). This will provide a far more clinically relevant diagnosis, and would aid in research on treatment in more homogenous groups of patients with chronic airways obstruction. More research is certainly needed to develop more evidence-based definitions for this patient group and to evaluate biomarkers, which will help to further classify these patients, treat them more adequately and unravel the underlying pathophysiological mechanism. PMID:26596632

  10. Asthma in Sickle Cell Disease: Implications for Treatment

    Directory of Open Access Journals (Sweden)

    Kathryn Blake

    2011-01-01

    Full Text Available Objective. To review issues related to asthma in sickle cell disease and management strategies. Data Source. A systematic review of pertinent original research publications, reviews, and editorials was undertaken using MEDLlNE, the Cochrane Library databases, and CINAHL from 1947 to November 2010. Search terms were [asthma] and [sickle cell disease]. Additional publications considered relevant to the sickle cell disease population of patients were identified; search terms included [sickle cell disease] combined with [acetaminophen], [pain medications], [vitamin D], [beta agonists], [exhaled nitric oxide], and [corticosteroids]. Results. The reported prevalence of asthma in children with sickle cell disease varies from 2% to approximately 50%. Having asthma increases the risk for developing acute chest syndrome , death, or painful episodes compared to having sickle cell disease without asthma. Asthma and sickle cell may be linked by impaired nitric oxide regulation, excessive production of leukotrienes, insufficient levels of Vitamin D, and exposure to acetaminophen in early life. Treatment of sickle cell patients includes using commonly prescribed asthma medications; specific considerations are suggested to ensure safety in the sickle cell population. Conclusion. Prospective controlled trials of drug treatment for asthma in patients who have both sickle cell disease and asthma are urgently needed.

  11. Heavy liquid metals: Research programs at PSI

    Energy Technology Data Exchange (ETDEWEB)

    Takeda, Y.

    1996-06-01

    The author describes work at PSI on thermohydraulics, thermal shock, and material tests for mechnical properties. In the presentation, the focus is on two main programs. (1) SINQ LBE target: The phase II study program for SINQ is planned. A new LBE loop is being constructed. The study has the following three objectives: (a) Pump study - design work on an electromagnetic pump to be integrated into the target. (b) Heat pipe performance test - the use of heat pipes as an additional component of the target cooling system is being considered, and it may be a way to futher decouple the liquid metal and water coolant loops. (c) Mixed convection experiment - in order to find an optimal configuration of the additional flow guide for window cooling, mixed convection around the window is to be studied. The experiment will be started using water and then with LBE. (2) ESS Mercury target: For ESS target study, the following experimental studies are planned, some of which are exampled by trial experiments. (a) Flow around the window: Flow mapping around the hemi-cylindrical window will be made for optimising the flow channels and structures, (b) Geometry optimisation for minimizing a recirculation zone behind the edge of the flow separator, (c) Flow induced vibration and buckling problem for a optimised structure of the flow separator and (d) Gas-liquid two-phase flow will be studied by starting to establish the new experimental method of measuring various kinds of two-phase flow characteristics.

  12. 儿童哮喘认知功能障碍的研究进展%Research of Cognitive Impairment in Children with Asthma

    Institute of Scientific and Technical Information of China (English)

    贺海兰(综述); 谢庆玲(审校)

    2014-01-01

    Bronchial asthma is a common chronic respiratory disease in children. That of poor control of asthma or uncontrolled asthma may result in cognitive dysfunction. The main clinical manifestations of cogni-tive deficits in children with asthma could be intelligence, attention , vigilance , learning and memory, and executive functions. Asthma-induced intermittent hypoxia and sleep disturbance could be the factors most frequently associated with cognitive deficits in asthmatic children. Neurocognitive impairment can be meas-ured objectively with examinations such as neuropsychological evaluation, electroneurophysiology and brain imaging techniques. Reasonable anti-asthma treatment could improve the clinical symptoms of asthma,which could likely be a positive role to prevent and treat cognitive dysfunction in asthmatic children.%支气管哮喘是儿童常见的慢性呼吸道疾病,哮喘持续控制不佳或迁延不愈可引起哮喘患儿认知功能障碍。儿童哮喘的认知功能障碍主要临床表现为智力、注意力、学习记忆力、执行功能的下降。哮喘症状反复发作引起的间歇性缺氧和睡眠障碍可能与患儿认知功能障碍有关。神经心理学、神经电生理及神经影像学的应用,为哮喘患儿认知功能评估提供了客观的量化依据。合理的抗哮喘治疗可改善临床哮喘症状,对儿童哮喘认知功能障碍有积极防治作用。

  13. Development of Education and Training Programs Using ISIS Research Reactor

    International Nuclear Information System (INIS)

    As a part of the French Alternative Energies and Atomic Energy Commission (CEA), the National Institute for Nuclear Science and Technology (INSTN) carries out various education and training programs on nuclear reactor theory and operation. These programs take advantage of the use of an extensive range of training tools that includes software applications, simulators, as well as the use of research reactors. After a presentation of ISIS reactor, we present the training courses that have been developed on ISIS reactor and their use in education and training programs developed by INSTN. We report on how the training courses carried out on ISIS research reactor ensure a practical and comprehensive understanding of the reactor principle and operation, bringing tremendous benefit to the trainees. We also discuss the future development of education and training programs using the ISIS research reactor as a very powerful tool for the development of the human resources needed by the nuclear industry and the nuclear programs. (author)

  14. The Significance of Asthma Follow-Up Consultations for Adherence to Asthma Medication, Asthma Medication Beliefs, and Asthma Control

    OpenAIRE

    Malin Axelsson; Linda Ekerljung; Bo Lundbäck

    2015-01-01

    Objective. The aim was to investigate adherence to asthma medication treatment, medication beliefs, and asthma control in relation to asthma follow-up consultations in asthmatics in the general population. A further aim was to describe associations between adherence, medication beliefs, and asthma control. Method. In the population-based West Sweden Asthma Study, data allowing calculation of adherence for 4.5 years based on pharmacy records were obtained from 165 adult asthmatics. Additional ...

  15. Screening for asthma in children.

    OpenAIRE

    Jones, A.

    1994-01-01

    The primary health care team is at the forefront of asthma management and there is evidence of improved delivery of care via nurse run, audited, general practice clinics. However, hospital admissions for asthma continue to rise. Screening for childhood asthma would appear to have advantages for patient care. This review looks critically at the literature that addresses important issues in screening for childhood asthma, including the problem of defining asthma, its prevalence rate and the imp...

  16. Obstructive sleep apnea and asthma*

    OpenAIRE

    Cristina Salles; Regina Terse-Ramos; Adelmir Souza-Machado; Cruz, Alvaro A

    2013-01-01

    Symptoms of sleep-disordered breathing, especially obstructive sleep apnea syndrome (OSAS), are common in asthma patients and have been associated with asthma severity. It is known that asthma symptoms tend to be more severe at night and that asthma-related deaths are most likely to occur during the night or early morning. Nocturnal symptoms occur in 60-74% of asthma patients and are markers of inadequate control of the disease. Various pathophysiological mechanisms are related to the worseni...

  17. Energy efficient industrialized housing research program

    Energy Technology Data Exchange (ETDEWEB)

    Berg, R.; Brown, G.Z.; Finrow, J.; Kellett, R.; McDonald, M.; McGinn, B.; Ryan, P.; Sekiguchi, Tomoko (Oregon Univ., Eugene, OR (USA). Center for Housing Innovation); Chandra, S.; Elshennawy, A.K.; Fairey, P.; Harrison, J.; Maxwell, L.; Roland, J.; Swart, W. (Florida Solar Energy Center, Cape Canaveral, FL (USA))

    1990-02-01

    This report summarizes three documents: Multiyear Research Plan, Volume I FY 1989 Task Reports, and Volume II Appendices. These documents describe tasks that were undertaken from November 1988 to December 1989, the first year of the project. Those tasks were: (1) the formation of a steering committee, (2) the development of a multiyear research plan, (3) analysis of the US industrialized housing industry, (4) assessment of foreign technology, (5) assessment of industrial applications, (6) analysis of computerized design and evaluation tools, and (7) assessment of energy performance of baseline and advanced industrialized housing concepts. While this document summarizes information developed in each task area, it doesn't review task by task, as Volume I FY 1989 Task Reports does, but rather treats the subject of energy efficient industrialized housing as a whole to give the reader a more coherent view. 7 figs., 9 refs.

  18. Coconut Program Area Research Planning and Prioritization

    OpenAIRE

    Aragon, Corazon

    2000-01-01

    The coconut industry is one of the country's major pillars in employment generation and foreign exchange earnings. However, local production problems, the expansion in coconut hectarage of neighboring countries, and recent developments in biotechnology research on other competing crops that have high lauric oil content might affect its long-term sustainability and viability. In a highly liberalized global trade environment, innovation and creativity in the country's coconut industry are neede...

  19. Research Breathes New Life Into Senior Travel Program.

    Science.gov (United States)

    Blazey, Michael

    1986-01-01

    A survey of older citizens concerning travel interests revealed constraints to participation in a travel program. A description is given of how research on attitudes and life styles indicated ways in which these constraints could be lessened. (JD)

  20. Northeast Cooperative Research Study Fleet (SF) Program Biological Sampling Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Northeast Cooperative Research Study Fleet (SF) Program partners with a subset of commercial fishermen to collect high quality, high resolution, haul by haul...

  1. Research to protect water infrastructure: EPA's water security research program

    Science.gov (United States)

    Herrmann, Jonathan G.

    2005-05-01

    As the federal lead for water infrastructure security, EPA draws upon its long history of environmental protection to develop new tools and technologies that address potential attacks on drinking water and wastewater systems. The critical research described is improving awareness, preparedness, prevention, response, and recovery from threats or attacks against water systems.

  2. Clean coal technologies: Research, development, and demonstration program plan

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-01

    The US Department of Energy, Office of Fossil Energy, has structured an integrated program for research, development, and demonstration of clean coal technologies that will enable the nation to use its plentiful domestic coal resources while meeting environmental quality requirements. The program provides the basis for making coal a low-cost, environmentally sound energy choice for electric power generation and fuels production. These programs are briefly described.

  3. Programs of the Office of Energy Research: Revision

    International Nuclear Information System (INIS)

    In establishing each of the Federal Agencies that have been successively responsible for energy technologies and their development - the Atomic Energy Commission, the Energy Research and Development Administration, and, currently, the US Department of Energy (DOE) - Congress made specific provisions for the conduct of advanced and fundamental research. The purpose of this research has been to support the energy technology development programs by providing insight into fundamental science and associated phenomena and developing new or advanced concepts and techniques. Today, this responsibility rests with the Office of Energy Research (ER), DOE, whose present programs have their origins in pioneering energy-related research of this nature, which was initiated nearly 40 years ago. The Director, Office of Energy Research, also acts as the chief scientist and scientific advisor to the Secretary of Energy for the entire spectrum of energy research and development (R and D) programs of the Department. ER programs include several thousand individual projects and hundreds of laboratories, universities, and other research facilities throughout the Unites States. In the following pages, each of these programs and activities are described briefly for the information of the scientific community and the public at large. 5 figs., 6 tabs

  4. Tobaksrygning og asthma

    DEFF Research Database (Denmark)

    Ulrik, Charlotte Suppli; Lange, Peter

    2002-01-01

    Cigarette smoking is a well-known health hazard, probably not least for patients suffering from asthma. This review gives a short overview of the effects of passive and active smoking on the inception and outcome with of longitudinal changes in the lung function and mortality of patients with ast......Cigarette smoking is a well-known health hazard, probably not least for patients suffering from asthma. This review gives a short overview of the effects of passive and active smoking on the inception and outcome with of longitudinal changes in the lung function and mortality of patients...... with asthma. Substantial evidence suggests that smoking affects asthma adversely. Exposure to environmental tobacco smoke, especially maternal smoking in children, may be a significant risk factor for asthma. Such exposure in patients with established asthma is not only associated with more severe symptoms......, but also with a poorer quality of life, reduced lung function, and increased utilisation of health care including hospital admissions. Active smoking does not appear to be a significant risk factor for asthma, but is associated with a worse outcome with regard to both longitudinal changes in lung function...

  5. Asthma in adolescent athletes.

    Science.gov (United States)

    Carlsen, Kai-Håkon; Hem, Erlend; Stensrud, Trine

    2011-12-01

    Athletes active in endurance sports are at an increased risk of acquiring asthma through their sports activities, especially so for cross-country skiers, biathlon skiers, swimmers and athletes of other endurance sports. Asthma may be present from early childhood or develop while in active sports. This article focuses on the physical activity and sports activities in children and adolescents. Exercise-induced asthma (EIA) is found in 8-10% of a normal child population of school age and in about 35% of children with current asthma. EIA is caused by the markedly increased ventilation during exercise, with increased heat and water loss through respiration, leading to bronchial constriction. The risk of developing asthma in the young athlete is related to the repeated daily training activity with increased epithelial damage of the airways, delayed repair due to the daily repetition of the training and increased airway mucosal inflammation. The increased environmental exposure through the sports activity to environmental agents, such as cold, dry air in skiers and chlorine compounds in swimmers, increases symptoms and signs of asthma and bronchial hyper-responsiveness, either worsening an existing asthma or leading to a novel disease in a previously healthy athlete. Several specific aspects of daily training life, environmental exposure, diagnostic procedures and aspects of treatment related to the regulations of medication use in sports need particular attention when addressing the adolescent athlete with respiratory symptoms.

  6. Massachusetts Institute of Technology, Plasma Fusion Center, Technical Research Programs

    International Nuclear Information System (INIS)

    A review is given of the technical programs carried out by the Plasma Fusion Center. The major divisions of work areas are applied plasma research, confinement experiments, fusion technology and engineering, and fusion systems. Some objectives and results of each program are described

  7. Program Evaluation and Research Designs. NBER Working Paper No. 16016

    Science.gov (United States)

    DiNardo, John; Lee, David S.

    2010-01-01

    This chapter provides a selective review of some contemporary approaches to program evaluation. One motivation for our review is the recent emergence and increasing use of a particular kind of "program" in applied microeconomic research, the so-called Regression Discontinuity (RD) Design of Thistlethwaite and Campbell (1960). We organize our…

  8. Laboratory Directed Research and Development Program Assessment for FY 2014

    Energy Technology Data Exchange (ETDEWEB)

    Hatton, D. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2014-03-01

    Each year, Brookhaven National Laboratory (BNL) is required to provide a program description and overview of its Laboratory Directed Research and Development Program (LDRD) to the Department of Energy in accordance with DOE Order 413.2B dated April 19, 2006. This report fulfills that requirement.

  9. Massachusetts Institute of Technology, Plasma Fusion Center, Technical Research Programs

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, Ronald C.

    1980-08-01

    A review is given of the technical programs carried out by the Plasma Fusion Center. The major divisions of work areas are applied plasma research, confinement experiments, fusion technology and engineering, and fusion systems. Some objectives and results of each program are described. (MOW)

  10. Next Steps for Research and Practice in Career Programming

    Science.gov (United States)

    Hynes, Kathryn

    2012-01-01

    Career programming is a useful framework for thinking about how to support youth development across schools and multiple out-of-school-time contexts. The articles in this issue of "New Directions for Youth Development" highlight the broad research base relevant to career programming from which policy and practice can draw. This concluding article…

  11. U.S. Nuclear Regulatory Commission natural analogue research program

    Energy Technology Data Exchange (ETDEWEB)

    Kovach, L.A.; Ott, W.R. [Nuclear Regulatory Commission, Washington, DC (United States)

    1995-09-01

    This article describes the natural analogue research program of the U.S. Nuclear Regulatory Commission (US NRC). It contains information on the regulatory context and organizational structure of the high-level radioactive waste research program plan. It also includes information on the conditions and processes constraining selection of natural analogues, describes initiatives of the US NRC, and describes the role of analogues in the licensing process.

  12. The role of research in NRC regulatory programs

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, S.A.

    1996-03-01

    This article is the text of the opening remarks by NRC Chairwoman Shirley Jackson to the Reactor Safety Meeting. In her remarks, Dr. Jackson discusses the role of research in NRC regulatory programs and points out by way of example that many of the research programs provide considerable benefit to the industry as well as to the Commission. She then outlines current activities as well as future plans.

  13. 支气管哮喘控制程度与抑郁相关性研究%Bronchial asthma control degree with depression correlation research

    Institute of Scientific and Technical Information of China (English)

    杜淑珍; 常晓悦

    2011-01-01

    Objective The bronchial asthma (asthma) is a serious harm to the health of the human,and depression play an important role in asthma development and prognosis [1].This study discusses the correlation between asthma control degree and the depression.Methods We made a scale of ACQ and HAMD to test consistency in 50 cases for patients of asthma.And we did dada analysis in SPSS 13.0statistics software.Results ①There exists different degree of depression about 70% of the patients and the heavier asthma with the heavier depression.②After asthma treatment standardized for three months,depression degree and asthma control degree is still a linear positive correlation.Conclusions The asthma not only influence the quality of life serious,and can cause psychological barriers,such as depression,anxiety and fear.That treatment and management asthma standardized can reduce the incidence of depression and improve depression.At the same time,biological,social and psychological depends on each other,mutual penetration,affecting each other in asthma development process.They are form a complex network system,we only study with asthma development in the more broad background allround,multi-level,it will be possible to control asthma effective.%目的 支气管哮喘(简称哮喘)是一种严重危害人类健康的心身疾病,而伴发的抑郁在哮喘的发生、发展和预后中发挥着重要作用[1].本研究诣在探讨哮喘控制程度与抑郁之间存在的相关性.方法 对50例哮喘患者应用制定哮喘控制测试(ACQ)评分表及汉密尔顿抑郁量表(HAMD),作一致性测试.并进行SPSS 13.0统计学软件进行数据分析.结果 ①70%的患者存在不同程度抑郁,而且哮喘越重抑郁的程度越重.②哮喘规范治疗3个月后,抑郁程度与哮喘的控制程度仍呈线性正相关.结论 哮喘不但严重影响患者的生活质量,而且可以引起心理障碍,多表现为抑郁、焦虑和恐惧[2].规范治疗和管理哮喘

  14. The Effects of Combining Web-Based eHealth With Telephone Nurse Case Management for Pediatric Asthma Control: A Randomized Controlled Trial

    OpenAIRE

    Gustafson, David; Wise, Meg; Bhattacharya, Abhik; Pulvermacher, Alice; Shanovich, Kathleen; Phillips, Brenda; Lehman, Erik; Chinchilli, Vernon; Hawkins, Robert; Kim, Jee-Seon

    2012-01-01

    Background Asthma is the most common pediatric illness in the United States, burdening low-income and minority families disproportionately and contributing to high health care costs. Clinic-based asthma education and telephone case management have had mixed results on asthma control, as have eHealth programs and online games. Objectives To test the effects of (1) CHESS+CM, a system for parents and children ages 4–12 years with poorly controlled asthma, on asthma control and medication adheren...

  15. Process and Outcomes of School Nurse Case Management for Students with Asthma

    Science.gov (United States)

    Engelke, Martha Keehner; Swanson, Melvin; Guttu, Martha

    2014-01-01

    There have been many studies that have examined the impact of school-based asthma programs on students with asthma. However, most studies do not provide adequate elaboration on the components of the program. Therefore, replication of these programs is difficult. This study examines the process of school nurse case management, which includes the…

  16. Overview of ARB's Greenhouse Gas Research Program

    Science.gov (United States)

    Falk, M.; Chen, Y.; Kuwayama, T.; Vijayan, A.; Herner, J.; Croes, B.

    2015-12-01

    Since the passage of the California Global Warming Solutions Act (or AB32) in 2006, California Air Resources Board (ARB) has established and implemented a comprehensive plan to understand, quantify, and mitigate the various greenhouse gas (GHG) emission source sectors in the state. ARB has also developed a robust and multi-tiered in-house research effort to investigate methane (CH4), nitrous oxide (N2O) and fluorinated gas emission sources. This presentation will provide an overview of ARB's monitoring and measurement research efforts to study the regional and local emission sources of these pollutants in California. ARB initiated the first subnational GHG Research Monitoring Network in 2010 to study the regional GHG emissions throughout the state. The network operates several high precision analyzers to study CH4, N2O, CO and CO2 emissions at strategically selected regional sites throughout California, and the resulting data are used to study the statewide emission trends and evaluate regional sources using statistical analyses and inverse modeling efforts. ARB is also collaborating with leading scientists to study important emission sources including agriculture, waste, and oil and gas sectors, and to identify "hot spot" methane sources through aerial surveys of high methane emitters in California. At the source level, ARB deploys Mobile Measurement Platforms (MMP) and flux chambers to measure local and source specific emissions, and uses the information to understand source characteristics and inform emissions inventories. Collectively, all these efforts are offering a comprehensive view of regional and local emission sources, and are expected to help in developing effective mitigation strategies to reduce GHG emissions in California.

  17. Research program in elementary particle theory

    International Nuclear Information System (INIS)

    Discussed in this paper is a brief account of the research work of the principal investigators and their co-workers during the past few years. The topics covered include: Topology in Physics; Skyrme Model; High Temperature Superconductivity; fractional statistics, and generalized spin statistics theorem; QCD as a dual chromomagnetic superconductor; confinement and string picture in QCD; quark gluon plasmas; cosmic strings; effective Lagrangians for QCD; ''proton spin,'' ''strange content'' and related topics; physical basis of the Skyrme model; gauge theories and weak interactions; grand unification; Universal ''see saw mechanism''; abelian and non-abelian interactions of a test string

  18. Disparities in Asthma Care, Management, and Education Among Children With Asthma

    Science.gov (United States)

    Holsey, Chanda N.; Collins, Pamela; Zahran, Hatice

    2016-01-01

    Health disparities are pervasive in the United States. Health and health care disparities are the differences or gaps in health (eg, life expectancy, morbidity, risk factors, and quality of life) and health care access and quality between segments of the United States population as related to race/ethnicity and socioeconomic status (eg, income, education). Multiple factors are associated with such disparities in asthma management and education. This article explores some of those factors and summarizes the strategies developed and interventions implemented to address disparities associated with asthma care and education among racial and ethnic minority children. It also discusses the need for further research to identify effective asthma education approaches for improving the management of asthma among racial and ethnic minority children. More exploration of the root causes of health care disparities, including policy studies in the area of social determinates of health and health equity, is also needed.

  19. Breathing Better Through Bugs: Asthma and the Microbiome

    Science.gov (United States)

    Adami, Alexander J.; Bracken, Sonali J.

    2016-01-01

    Asthma is a highly heterogeneous disease characterized by inflammation of the airways, which invokes symptoms such as wheeze, dyspnea, and chest tightness. Asthma is the product of multiple interconnected immunological processes and represents a constellation of related, but distinct, disease phenotypes. The prevalence of asthma has more than doubled since the 1980s, and efforts to understand this increase have inspired consideration of the microbiome as a key player in the pathophysiology and regulation of this disease. While recent years have seen an explosion of new research in this area, researchers are only beginning to untangle to mechanisms by which the microbiome may influence asthma. This review will focus on the relationship between the microbiome and the immune system and how this influences development of asthma. This review will also highlight evidence that may point the way toward new therapies and potential cures for this ancient respiratory foe.

  20. Successfully Integrating Research into Plastic Surgery Training Programs.

    Science.gov (United States)

    Ballard, Tiffany N S; Sando, Ian C; Kasten, Steven J; Cederna, Paul S

    2015-11-01

    Successful integration of research into the educational mission of a plastic surgery residency program requires the support and dedication of the faculty members to create a culture that promotes innovation, discovery, and advancement of the field of plastic surgery. Dedicated research time during plastic surgery training is beneficial to both the resident and training program. Regardless of whether residents plan to pursue an academic career or enter private practice, participating in research provides an opportunity to develop skills to think critically and mature professionally. In this article, we review the benefits of resident research to both the trainee and training program and discuss strategies to overcome barriers to integrating research into the curriculum. PMID:26517468

  1. Eosinophilic Endotype of Asthma.

    Science.gov (United States)

    Aleman, Fernando; Lim, Hui Fang; Nair, Parameswaran

    2016-08-01

    Asthma is a heterogeneous disease that can be classified into different clinical endotypes, depending on the type of airway inflammation, clinical severity, and response to treatment. This article focuses on the eosinophilic endotype of asthma, which is defined by the central role that eosinophils play in the pathophysiology of the condition. It is characterized by elevated sputum and/or blood eosinophils on at least 2 occasions and by a significant response to treatments that suppress eosinophilia. Histopathologic demonstration of eosinophils in the airways provides the most direct diagnosis of eosinophilic asthma; but it is invasive, thus, impractical in clinical practice. PMID:27401626

  2. Research program with no ''measurement problem''

    International Nuclear Information System (INIS)

    The ''measurement problem'' of contemporary physics is met by recognizing that the physicist participates when constructing and when applying the theory consisting of the formulated formal and measurement criteria (the expressions and rules) providing the necessary conditions which allow him to compute and measure facts, yet retains objectivity by requiring that these criteria, rules and facts be in corroborative equilibrium. We construct the particulate states of quantum physics by a recursive program which incorporates the non-determinism born of communication between asynchronous processes over a shared memory. Their quantum numbers and coupling constants arise from the construction via the unique 4-level combinatorial hierarchy. The construction defines indivisible quantum events with the requisite supraluminal correlations, yet does not allow supraluminal communication. Measurement criteria incorporate c, h-bar, and m/sub p/ or (not ''and'') G. The resulting theory is discrete throughout, contains no infinities, and, as far as we have developed it, is in agreement with quantum mechanical and cosmological fact

  3. Human Factors Regulatory Research Program Plan, FY 1989--FY 1992

    International Nuclear Information System (INIS)

    This report describes the currently ongoing (FY 1989) and planned (FY 1989-1992) Human Factors Regulatory Research Program in the NRC Office of Nuclear Regulatory Research (RES). Examples of the influence of human factors on nuclear safety are presented, and the role of personnel is discussed. Current regulatory issues associated with human factors in the nuclear system and the purpose of the research plan are provided. The report describes the research process applied to the human factors research issues and the program activities: Personnel Performance Measurement, Personnel Subsystem, Human-System Interface. Organization and Management, and Reliability Assessment. The research being conducted within each activity is summarized along with the objectives, background information, and expected regulatory products. Budget and personnel forecasts are provided along with a summary of contractors performing some of the ongoing research. Appendices contain a chronology of human factors research at NRC, a description of the research approach, an update on human factors programs and initiatives in RES and other NRC offices, and the integration among these programs. 46 refs., 5 tabs

  4. Energy efficient industrialized housing research program

    Energy Technology Data Exchange (ETDEWEB)

    Berg, R.; Brown, G.Z.; Finrow, J.; Kellett, R.; McDonald, M.; McGinn, B.; Ryan, P.; Sekiguchi, Tomoko (Oregon Univ., Eugene, OR (USA). Center for Housing Innovation); Chandra, S.; Elshennawy, A.K.; Fairey, P.; Harrison, J.; Mazwell, L.; Roland, J.; Swart, W. (Florida Solar Energy Center, Cape Canaveral, FL (USA))

    1989-12-01

    This document describes the research work completed in five areas in fiscal year 1989. (1) The analysis of the US industrialized housing industry includes statistics, definitions, a case study, and a code analysis. (2) The assessment of foreign technology reviews the current status of design, manufacturing, marketing, and installation of industrialized housing primarily in Sweden and Japan. (3) Assessment of industrialization applications reviews housing production by climate zone, has a cost and energy comparison of Swedish and US housing, and discusses future manufacturing processes and emerging components. (4) The state of computer use in the industry is described and a prototype design tool is discussed. (5) Side by side testing of industrialized housing systems is discussed.

  5. Sandia Combustion Research Program: Annual report, 1986

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    This report presents research results of the past year, divided thematically into some ten categories. Publications and presentations arising from this work are included in the appendix. Our highlighted accomplishment of the year is the announcement of the discovery and demonstration of the RAPRENOx process. This new mechanism for the elimination of nitrogen oxides from essentially all kinds of combustion exhausts shows promise for commercialization, and may eventually make a significant contribution to our nation's ability to control smog and acid rain. The sections of this volume describe the facility's laser and computer system, laser diagnostics of flames, combustion chemistry, reacting flows, liquid and solid propellant combustion, mathematical models of combustion, high-temperature material interfaces, studies of engine/furnace combustion, coal combustion, and the means of encouraging technology transfer. 182 refs., 170 figs., 12 tabs.

  6. PERSEUS- European Space Research Program for Students

    Science.gov (United States)

    Oswald, J.; Galeon, A.

    2015-09-01

    PERSEUS is a french acronyme for “Projet Etudiant de Recherche Spatiale Europeen Universitaire et Scientifique”. The PERSEUS project provides the opportunity for motivated students to pool their knowledge to the development of Nano Satellite Launcher. Their applicative work refers to a subscale of a Nano Satellite Launcher which corresponds to a more or less powerful experimental rocket. They can work either through the classical pedagogic frame proposed by their university, either in a space association or as researchers in a laboratory. The CNES (French Space Agency) with the help of partners (AJSEP, Bertin Technologies, GAREF, HERAKLES, IPSA, ISAE-Supaero, MI-GSO, ONERA, Planètes Sciences, ROXEL, UEVE) is coordinating all these activities in order to achieve a complete life cycle of prototypes: objectives, studies, development realization, reviews, ground or flight test and exploitation.

  7. Danish Integrated Antimicrobial Resistance Monitoring and Research Program

    Science.gov (United States)

    Heuer, Ole E.; Emborg, Hanne-Dorthe; Bagger-Skjøt, Line; Jensen, Vibeke F.; Rogues, Anne-Marie; Skov, Robert L.; Agersø, Yvonne; Brandt, Christian T.; Seyfarth, Anne Mette; Muller, Arno; Hovgaard, Karin; Ajufo, Justin; Bager, Flemming; Aarestrup, Frank M.; Frimodt-Møller, Niels; Wegener, Henrik C.; Monnet, Dominique L.

    2007-01-01

    Resistance to antimicrobial agents is an emerging problem worldwide. Awareness of the undesirable consequences of its widespread occurrence has led to the initiation of antimicrobial agent resistance monitoring programs in several countries. In 1995, Denmark was the first country to establish a systematic and continuous monitoring program of antimicrobial drug consumption and antimicrobial agent resistance in animals, food, and humans, the Danish Integrated Antimicrobial Resistance Monitoring and Research Program (DANMAP). Monitoring of antimicrobial drug resistance and a range of research activities related to DANMAP have contributed to restrictions or bans of use of several antimicrobial agents in food animals in Denmark and other European Union countries. PMID:18217544

  8. Pooling birth cohorts in allergy and asthma

    DEFF Research Database (Denmark)

    Bousquet, Jean; Anto, Josep; Sunyer, Jordi;

    2013-01-01

    Long-term birth cohort studies are essential to understanding the life course and childhood predictors of allergy and the complex interplay between genes and the environment (including lifestyle and socioeconomic determinants). Over 100 cohorts focusing on asthma and allergy have been initiated i...... of this paper is to review current and past EU-funded projects in order to make a summary of their goals and achievements and to suggest future research needs of these European birth cohort networks....... in the world over the past 30 years. Since 2004, several research initiatives funded under the EU Framework Program for Research and Technological Development FP6-FP7 have attempted to identify, compare, and evaluate pooling data from existing European birth cohorts (GA(2)LEN: Global Allergy and European...... Network, FP6; ENRIECO: Environmental Health Risks in European Birth Cohorts, FP7; CHICOS: Developing a Child Cohort Research Strategy for Europe, FP7; MeDALL: Mechanisms of the Development of ALLergy, FP7). However, there is a general lack of knowledge about these initiatives and their potentials. The aim...

  9. Rutgers Young Horse Teaching and Research Program: undergraduate student outcomes.

    Science.gov (United States)

    Ralston, Sarah L

    2012-12-01

    Equine teaching and research programs are popular but expensive components of most land grant universities. External funding for equine research, however, is limited and restricts undergraduate research opportunities that enhance student learning. In 1999, a novel undergraduate teaching and research program was initiated at Rutgers University, New Brunswick, NJ. A unique aspect of this program was the use of young horses generally considered "at risk" and in need of rescue but of relatively low value. The media interest in such horses was utilized to advantage to obtain funding for the program. The use of horses from pregnant mare urine (PMU) ranches and Bureau of Land Management (BLM) mustangs held the risks of attracting negative publicity, potential of injury while training previously unhandled young horses, and uncertainty regarding re-sale value; however, none of these concerns were realized. For 12 years the Young Horse Teaching and Research Program received extensive positive press and provided invaluable learning opportunities for students. Over 500 students, at least 80 of which were minorities, participated in not only horse management and training but also research, event planning, public outreach, fund-raising, and website development. Public and industry support provided program sustainability with only basic University infrastructural support despite severe economic downturns. Student research projects generated 25 research abstracts presented at national and international meetings and 14 honors theses. Over 100 students went on to veterinary school or other higher education programs, and more than 100 others pursued equine- or science-related careers. Laudatory popular press articles were published in a wide variety of breed/discipline journals and in local and regional newspapers each year. Taking the risk of using "at risk" horses yielded positive outcomes for all, especially the undergraduate students. PMID:22767090

  10. Radiochemistry Education and Research Program at the Pennsylvania State University

    Science.gov (United States)

    Ünlü, Kenan

    2009-08-01

    A new Radiochemistry Education and Research Program was started at the Pennsylvania University, Radiation Science and Engineering Center. The program was initially supported by the Department of Energy, Radiochemistry Education Award Program (REAP). Using REAP funding as leverage we obtained support from the Los Alamos National Laboratory, Department of Homeland Security, Domestic Nuclear Detection Office, various internal funding from PSU and other entities. The PSU radiochemistry program primarily addresses radiochemistry education and secondarily nuclear and radiochemistry research. The education program consists of bolstering our existing radiochemistry and related courses; Nuclear and Radiochemistry, Radiation Detection and Measurement, Radiological Safety and developing new courses, e.g., Laboratory Experiments in Applied Nuclear and Radiochemistry, and Nuclear Methods in Science. A new laboratory has been created with state of the art equipment for the Laboratory Experiments in Applied Nuclear and Radiochemistry course. We also plan to revitalize the nuclear and radiochemistry research programs. We established a state-of-the-art Neutron Activation Analysis Laboratory and a gamma ray spectroscopy laboratory that has 10 stations including state-of-the-art nuclear spectroscopy hardware and software. In addition, we embarked on an expansion plan that included building a new neutron beam hall and neutron beam ports with a cold neutron source. One of the reasons to have a cold neutron source is for the development of a prompt gamma activation analysis facility. A detailed description of PSU radiochemistry education and research program will be given and the future plans will be discussed.

  11. ROLE OF ENVIRONMENTAL AND PERSONAL FACTORS IN THE INITIATION OF ASTHMA IN SCHOOL-AGED CHILDREN: MICA STUDY

    Science.gov (United States)

    A number of environmental and personal factors have already been associated with the development and exacerbation of childhood asthma, but many aspects of this association require further research. The Mechanistic Indicators of Childhood Asthma (MICA) is an epidemiologic study t...

  12. Know How to Use Your Asthma Inhaler

    Medline Plus

    Full Text Available ... Outdoors Management Asthma Action Plan Flu Shots Inhalers Data, Statistics, and Surveillance Most Recent Asthma Data AsthmaStats Asthma-related Missed School Days among Children ...

  13. Know How to Use Your Asthma Inhaler

    Medline Plus

    Full Text Available ... 1 MB] ASL Asthma Film Asthma Clinical Guidelines Air Pollution & Respiratory Health Know How to Use Your ... 1 MB] ASL Asthma Film Asthma Clinical Guidelines Air Pollution & Respiratory Health File Formats Help: How do ...

  14. Know How to Use Your Asthma Inhaler

    Medline Plus

    Full Text Available ... Breathing Easier [PDF - 1.1 MB] ASL Asthma Film Asthma Clinical Guidelines Air Pollution & Respiratory Health Know ... Breathing Easier [PDF - 1.1 MB] ASL Asthma Film Asthma Clinical Guidelines Air Pollution & Respiratory Health File ...

  15. TCM Differential Treatment of Cough Variant Asthma

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhong-de; DENG Yi-qi; ZHANG Yu; HAN Yun; LIN Lin; CHAO En-xiang

    2010-01-01

    @@ Cough variant asthma (CVA), also called latent asthma or cough asthma, is a special type of asthma. With gradually deepened understanding of CVA in recent years, good curative effect has been achieved in TCM treatment of CVA.

  16. Know How to Use Your Asthma Inhaler

    Medline Plus

    Full Text Available ... PDF - 1.1 MB] ASL Asthma Film Asthma Clinical Guidelines Air Pollution & Respiratory Health Know How to ... PDF - 1.1 MB] ASL Asthma Film Asthma Clinical Guidelines Air Pollution & Respiratory Health File Formats Help: ...

  17. Know How to Use Your Asthma Inhaler

    Medline Plus

    Full Text Available ... J K L M N O P Q R S T U V W X Y Z # Start ... Management Asthma Action Plan Flu Shots Inhalers Data, Statistics, and Surveillance Most Recent Asthma Data AsthmaStats Asthma- ...

  18. Management and research priorities of NASA 'Human Research Program'

    International Nuclear Information System (INIS)

    Research on humans has been the focus of the United States space biomedical research, while 'Human Research Program', as an important project initiated by NASA, aims to reduce the risks to the health and performance of astronauts. This paper analyzed this project in terms of organization and management, funding investment and research directions. (authors)

  19. Nuclear Explosion Monitoring Research and Engineering Program - Strategic Plan

    Energy Technology Data Exchange (ETDEWEB)

    Casey, Leslie A. [DOE/NNSA

    2004-09-01

    The Department of Energy (DOE)/National Nuclear Security Administration (NNSA) Nuclear Explosion Monitoring Research and Engineering (NEM R&E) Program is dedicated to providing knowledge, technical expertise, and products to US agencies responsible for monitoring nuclear explosions in all environments and is successful in turning scientific breakthroughs into tools for use by operational monitoring agencies. To effectively address the rapidly evolving state of affairs, the NNSA NEM R&E program is structured around three program elements described within this strategic plan: Integration of New Monitoring Assets, Advanced Event Characterization, and Next-Generation Monitoring Systems. How the Program fits into the National effort and historical accomplishments are also addressed.

  20. Supporting medical education research quality: the Association of American Medical Colleges' Medical Education Research Certificate program.

    Science.gov (United States)

    Gruppen, Larry D; Yoder, Ernie; Frye, Ann; Perkowski, Linda C; Mavis, Brian

    2011-01-01

    The quality of the medical education research (MER) reported in the literature has been frequently criticized. Numerous reasons have been provided for these shortcomings, including the level of research training and experience of many medical school faculty. The faculty development required to improve MER can take various forms. This article describes the Medical Education Research Certificate (MERC) program, a national faculty development program that focuses exclusively on MER. Sponsored by the Association of American Medical Colleges and led by a committee of established medical education researchers from across the United States, the MERC program is built on a set of 11 interactive workshops offered at various times and places across the United States. MERC participants can customize the program by selecting six workshops from this set to fulfill requirements for certification. This article describes the history, operations, current organization, and evaluation of the program. Key elements of the program's success include alignment of program content and focus with needs identified by prospective users, flexibility in program organization and logistics to fit participant schedules, an emphasis on practical application of MER principles in the context of the participants' activities and interests, consistency in program content and format to ensure standards of quality, and a sustainable financial model. The relationship between the national MERC program and local faculty development initiatives is also described. The success of the MERC program suggests that it may be a possible model for nationally disseminated faculty development programs in other domains.