WorldWideScience

Sample records for astatine 218

  1. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production.

  2. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  3. Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Jakobsson, U., E-mail: ulrjak@kth.se; Cederwall, B. [KTH, The Division of Nuclear Physics, AlbaNova University Center, SE-10691 Stockholm (Sweden); Uusitalo, J.; Auranen, K.; Badran, H.; Cox, D. M.; Grahn, T.; Greenlees, P. T.; Julin, R.; Juutinen, S.; Herzáň, A.; Konki, J.; Leino, M.; Mallaburn, M.; Pakarinen, J.; Papadakis, P.; Partanen, J.; Rahkila, P.; Sandzelius, M.; Sarén, J. [University of Jyvaskyla, Department of Physics, P.O. Box 35, FI-40014 University of Jyvaskyla (Finland); and others

    2015-10-15

    Low-lying states in neutron-deficient astatine and francium nuclei have been studied by means of in-beam and delayed spectroscopy. The 13/2{sup +} state has been observed in francium nuclei with a similar down-sloping trend as in neighbouring astatine and bismuth isotopes, as a function of decreasing neutron number. A systematic trend can also now be seen for the 1/2{sup +} state both in astatine and francium nuclei, where the level energy decreases steeply as a function of neutron number when moving further away from the neutron shell closure. This trend is very similar between astatine nuclei and their francium isotones. Moreover, shape coexistence has been observed between the 13/2{sup +} state and the spherical 9/2{sup −} ground state in {sup 203}Fr and {sup 205}Fr.

  4. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom

    2015-01-01

    and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting......To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...

  5. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    NARCIS (Netherlands)

    Rothe, S.; Andreyev, A. N.; Antalic, S.; Borschevsky, A.; Capponi, L.; Cocolios, T. E.; De Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.; Kaldor, U.; Kudryavtsev, Yuri; Koester, U.; Lane, J. F. W.; Lassen, J.; Liberati, V.; Lynch, K. M.; Marsh, B. A.; Nishio, K.; Pauwels, D.; Pershina, V.; Popescu, L.; Procter, T. J.; Radulov, D.; Raeder, S.; Rajabali, M. M.; Rapisarda, E.; Rossel, R. E.; Sandhu, K.; Seliverstov, M. D.; Sjoedin, A. M.; Van den Bergh, P.; Van Duppen, P.; Venhart, M.; Wakabayashi, Y.; Wendt, K. D. A.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviou

  6. 42 CFR 438.218 - Enrollee information.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Enrollee information. 438.218 Section 438.218 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... and Operation Standards § 438.218 Enrollee information. The requirements that States must meet...

  7. 10 CFR 218.12 - Pricing.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Pricing. 218.12 Section 218.12 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Supply Orders § 218.12 Pricing. The price for oil subject to a supply order issued pursuant to this subpart shall be based on the price...

  8. 49 CFR 218.35 - Yard limits.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Yard limits. 218.35 Section 218.35 Transportation... TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Trains and Locomotives § 218.35 Yard limits. (a) After August 1, 1977, yard limits must be designated by— (1) Yard limit signs, and (2) Timetable, train...

  9. 10 CFR 218.11 - Supply orders.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Supply orders. 218.11 Section 218.11 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Supply Orders § 218.11 Supply orders. (a) A supply order shall require that the firm to which it is issued take actions specified therein relating...

  10. 22 CFR 218.33 - Mediation.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Mediation. 218.33 Section 218.33 Foreign... § 218.33 Mediation. (a) Referral of complaints for mediation. The agency will refer to the Federal Mediation and Conciliation Service all complaints that: (1) fall within the jurisdiction of...

  11. 10 CFR 218.32 - Review.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Review. 218.32 Section 218.32 Energy DEPARTMENT OF ENERGY OIL STANDBY MANDATORY INTERNATIONAL OIL ALLOCATION Procedures § 218.32 Review. (a) Purpose and scope. This subpart establishes the procedures for the filing of an application for review of a supply...

  12. 7 CFR 58.218 - Surge tanks.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Surge tanks. 58.218 Section 58.218 Agriculture....218 Surge tanks. If surge tanks are used for hot milk, and temperatures of product including foam being held in the surge tank during processing, is not maintained at a minimum of 150 °F, then two...

  13. 22 CFR 218.11 - Standards.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Standards. 218.11 Section 218.11 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Standards for Determining Age Discrimination § 218.11 Standards. The standards each agency uses to determine whether an age distinction or age-related term...

  14. Dicty_cDB: SLA218 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLA218 (Link to dictyBase) - - - Contig-U16455-1 SLA218Z (Link... to Original site) - - SLA218Z 592 - - - - Show SLA218 Library SL (Link to library) Clone ID SLA218 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLA2-A/SLA218Q.Seq.d/ Representative seq. ID SLA21...8Z (Link to Original site) Representative DNA sequence >SLA218 (SLA218Q) /CSM/SL/SLA2-A/SLA218Q.Seq.d/ XXXXX...TAATAATTTT AA sequence update 1997. 5. 7 Translated Amino Acid sequence ---LSTEVKSVEMHHEQLPEARPGDNVGFNVKNVSV

  15. 36 CFR 21.8 - Employee certification.

    Science.gov (United States)

    2010-07-01

    ... Section 21.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR HOT SPRINGS NATIONAL PARK; BATHHOUSE REGULATIONS § 21.8 Employee certification. (a) Employees engaged as physical therapists must be licensed or certified by a State or territory of the United States to...

  16. 43 CFR 17.218 - New construction.

    Science.gov (United States)

    2010-10-01

    ... Accessibility Standards. (1) Effective as of August 15, 1990, design, construction, or alteration of buildings... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false New construction. 17.218 Section 17.218 Public Lands: Interior Office of the Secretary of the Interior NONDISCRIMINATION IN FEDERALLY...

  17. 42 CFR 93.218 - Person.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Person. 93.218 Section 93.218 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH...

  18. 49 CFR 218.22 - Utility employee.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Utility employee. 218.22 Section 218.22... employee. (a) A utility employee shall be subject to the Hours of Service Act, and the requirements for... parts 217, 219, and 228 of this chapter. (b) A utility employee shall perform service as a member...

  19. 27 CFR 24.218 - Other wine.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Other wine. 24.218 Section... THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.218 Other wine. (a) General. Other than standard wine not included in other sections in this subpart are considered other wine....

  20. Dicty_cDB: SLC218 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLC218 (Link to dictyBase) - - - Contig-U16287-1 SLC218E (Link to Original site) SLC2...18F 569 SLC218Z 279 SLC218P 848 SLC218E 701 Show SLC218 Library SL (Link to library) Clone ID SLC2...nal site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SL/SLC2-A/SLC218Q.Seq.d/ Representative seq. ID SLC2...18E (Link to Original site) Representative DNA sequence >SLC218 (SLC218Q) /CSM/SL/SLC2-A/SLC2...Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SLC218 (SLC2

  1. 28 CFR 2.218 - Revocation decisions.

    Science.gov (United States)

    2010-07-01

    ..., YOUTH OFFENDERS, AND JUVENILE DELINQUENTS District of Columbia Supervised Releasees § 2.218 Revocation... local crime (including a term of imprisonment resulting from a probation, parole, or supervised...

  2. Laser photodetachment of radioactive ions: towards the determination of the electronegativity of astatine

    CERN Multimedia

    Rothe, Sebastian; Welander, Jakob Emanuel; Chrysalidis, Katerina; Day Goodacre, Thomas; Fedosseev, Valentine; Fiotakis, Spyridon; Forstner, Oliver; Heinke, Reinhard Matthias; Johnston, Karl; Kron, Tobias; Koester, Ulli; Liu, Yuan; Marsh, Bruce; Ringvall Moberg, Annie; Rossel, Ralf Erik; Seiffert, Christoph; Studer, Dominik; Wendt, Klaus; Hanstorp, Dag

    2017-01-01

    Negatively charged ions are mainly stabilized through the electron correlation effect. A measure of the stability of a negative ion is the electron affinity, which the energy gain by attaching an electron to a neutral atom. This fundamental quantity is, due to the almost general lack of bound excited states, the only atomic property that can be determined with high accuracy for negative ions. We will present the results of the first laser photodetachment studies of radioactive negative ions at CERN-ISOLDE. The photodetachment threshold for the radiogenic iodine isotope 128I was measured successfully, demonstrating the performance of the upgraded GANDALPH experimental beam line. The first detection of photo-detached astatine atoms marks a milestone towards the determination of the EA of this radioactive element.

  3. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron affinity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photo-detachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral line width of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in off-line tests by the clear observation of the photo-detachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148.

  4. Dicty_cDB: SSH218 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSH218 (Link to dictyBase) - G21005 DDB0185803 Contig-U05324-1 SSH...218E (Link to Original site) - - - - - - SSH218E 360 Show SSH218 Library SS (Link to library) Clone ID SSH...riginal site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSH2-A/SSH218Q.Seq.d/ ...Representative seq. ID SSH218E (Link to Original site) Representative DNA sequence >SSH218 (SSH218Q) /CSM/SS/SSH2-A/SSH...fvf Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SSH218 (SSH218Q) /CSM/SS/SSH2-A/SSH

  5. 40 CFR 98.218 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Miscellaneous Uses of Carbonate § 98.218 Definitions. All terms used in this subpart... Table U-1 to Subpart U of Part 98—CO2 Emission Factors for Common Carbonates Mineral name—carbonate...

  6. 22 CFR 218.23 - Self-evaluation.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Self-evaluation. 218.23 Section 218.23 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Duties of Agency Recipients § 218.23 Self-evaluation. (a... written self-evaluation of its compliance under the act within 18 months of the effective date of...

  7. 37 CFR 2.18 - Correspondence, with whom held.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Correspondence, with whom held. 2.18 Section 2.18 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... Persons § 2.18 Correspondence, with whom held. (a) Establishing the correspondence address. (1) If...

  8. 14 CFR 21.8 - Approval of articles.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Approval of articles. 21.8 Section 21.8 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.8 Approval of articles. If an article is required to...

  9. 18 CFR 2.18 - Phased electric rate increase filings.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Phased electric rate increase filings. 2.18 Section 2.18 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Policy and Interpretations Under the Federal Power Act § 2.18 Phased electric rate increase filings....

  10. 5 CFR 179.218 - Additional administrative collection action.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Additional administrative collection action. 179.218 Section 179.218 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Salary Offset § 179.218 Additional administrative collection...

  11. Ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and ionic radii of element Uus (Z = 117) and astatine.

    Science.gov (United States)

    Chang, Zhiwei; Li, Jiguang; Dong, Chenzhong

    2010-12-30

    Multiconfiguration Dirac-Fock (MCDF) method was employed to calculate the first five ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and radii for the element Uus and its homologue At. Main valence correlation effects were taken into account. The Breit interaction and QED effects were also estimated. The uncertainties of calculated IPs, EAs, and IR for Uus and At were reduced through an extrapolation procedure. The good consistency with available experimental and other theoretical values demonstrates the validity of the present results. These theoretical data therefore can be used to predict some unknown physicochemical properties of element Uus, Astatine, and their compounds.

  12. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  13. 32 CFR 218.3 - Dose reconstruction methodology.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Dose reconstruction methodology. 218.3 Section... ATMOSPHERIC NUCLEAR TEST PROGRAM (1945-1962) § 218.3 Dose reconstruction methodology. (a) Concept. The specific methodology consists of the characterization of the radiation environments to which...

  14. 49 CFR 173.218 - Fish meal or fish scrap.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Fish meal or fish scrap. 173.218 Section 173.218... Fish meal or fish scrap. (a) Except as provided in Column (7) of the HMT in § 172.101 of this subchapter, fish meal or fish scrap, containing at least 6%, but not more than 12% water, is authorized...

  15. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  16. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  17. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  18. Phenotype abnormality: 218 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 218 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u724i decreased size ...in organ named epidermal pavement cell in organ named vascular leaf ... epidermal pavement cell|vascular leaf ... decreased size ...

  19. 18 CFR 157.218 - Changes in customer name.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Changes in customer... CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL... Act for Certain Transactions and Abandonment § 157.218 Changes in customer name. (a)...

  20. 33 CFR 157.218 - Dedicated clean ballast tanks: Alterations.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Dedicated clean ballast tanks... CARRYING OIL IN BULK Dedicated Clean Ballast Tanks on Tank Vessels General § 157.218 Dedicated clean ballast tanks: Alterations. The dedicated clean ballast tanks or equipment on a tank vessel that has...

  1. 20 CFR 725.218 - Conditions of entitlement; child.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Conditions of entitlement; child. 725.218... Conditions of entitlement; child. (a) An individual is entitled to benefits where he or she meets the... the child of a deceased miner who: (1) Was receiving benefits under section 415 or part C of title...

  2. MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Ying-fei [Institute Guangzhou of Advanced Technology, Chinese Academy of Sciences, Guangzhou (China); Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong (China); Zhang, Li [School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (China); Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong (China); Waye, Mary Miu Yee [School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (China); Fu, Wei-ming, E-mail: wm.fu@giat.ac.cn [Institute Guangzhou of Advanced Technology, Chinese Academy of Sciences, Guangzhou (China); School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (China); Zhang, Jin-fang, E-mail: zhangjf06@cuhk.edu.hk [Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong (China); School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (China); Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen (China)

    2015-05-15

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

  3. 36 CFR 223.218 - Consistency with plans, environmental standards, and other management requirements.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Consistency with plans, environmental standards, and other management requirements. 223.218 Section 223.218 Parks, Forests, and Public... Special Forest Products § 223.218 Consistency with plans, environmental standards, and other...

  4. 75 FR 3927 - Proposed Information Collection Request for the ETA 218, Benefit Rights and Experience Report...

    Science.gov (United States)

    2010-01-25

    ... Information Collection Request for the ETA 218, Benefit Rights and Experience Report; Comment Request on... unemployment compensation programs. The data in the ETA 218, Benefit Rights and Experience Report, includes... extension for the collection of the ETA 218, Benefit Rights and Experience report. Comments are...

  5. Electric charge spectrum of recoiling {sup 218}Po

    Energy Technology Data Exchange (ETDEWEB)

    Abou-Khalil, R. [Institut de Radioprotection et de Surete Nucleaire (IRSN)/Service d' Etudes et de Recherches en Aerodispersion des polluants et en Confinement, B.P 68, 91192 Gif-sur-Yvette Cedex (France); Departement de Recherches Subatomiques, Institut Pluridisciplinaire Hubert-Curien, Groupe de Radioprotection et Mesures Environnementales (RaMsEs), Universite Louis Pasteur Strasbourg I, BP 28, 67037 Strasbourg Cedex 2 (France); Michielsen, N., E-mail: nathalie.michielsen@irsn.f [Institut de Radioprotection et de Surete Nucleaire (IRSN)/Service d' Etudes et de Recherches en Aerodispersion des polluants et en Confinement, B.P 68, 91192 Gif-sur-Yvette Cedex (France); Della-Negra, S. [Institut de Physique Nucleaire (IPN), F-91406 Orsay (France); Nourreddine, A.; Baussan, E. [Departement de Recherches Subatomiques, Institut Pluridisciplinaire Hubert-Curien, Groupe de Radioprotection et Mesures Environnementales (RaMsEs), Universite Louis Pasteur Strasbourg I, BP 28, 67037 Strasbourg Cedex 2 (France)

    2009-10-15

    The chemical and physical properties of a radioactive nanometric aerosol are important in determining its behaviour in indoor atmospheres and play a major part in determining its potential health effects. In a well defined experimental system, mass spectrometry coupled to the Time-of-Flight technique, we measured the electric charge of {sup 218}Po at the end of its recoil path. The charge distribution of the recoiling {sup 218}Po is mainly neutral and singly charged with a very small multicharged fraction. In case of radon progeny embedded in solid matter this one can play a major role in the surface ionisation processes versus electron and ion emission induced by the passage of the alpha recoils through the surface.

  6. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  7. 9 CFR 93.218 - Import permits and applications for inspection for poultry.

    Science.gov (United States)

    2010-01-01

    ... inspection for poultry. 93.218 Section 93.218 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND...

  8. MicroRNA-218 modulates activities of glioma cells by targeting HMGB1

    Science.gov (United States)

    Gu, Jianjun; Xu, Rong; Li, Yaxing; Zhang, Jianhe; Wang, Shousen

    2016-01-01

    To explore the effects of microRNA-218 (miR-218) on glioma cell lines and the related mechanism. U251 and U87 cells were transfected with negative control, miR-218 mimic or miR-218 inhibitor using lipofectamine 2000. The expressions of mRNA and proteins were detected with qRT-PCR and Western blotting. The cell proliferation, apoptosis, migration and invasion were studied using MTT, flow cytometry, Transwell assay and scratch-wound assay, respectively. The targeting effect of HMGB1 by miR-218 was measured with luciferase reporter assay. The results showed that miR-218 was significantly downregulated while HMGB1 was upregulated in both glioma cell lines. Transfection of miR-218 significantly reduced the cell viability and colony formation, increased cell apoptosis and arrested cell in G0/G1 phase. Transfection of miR-218 also decreased the invasion and migration of glioma cells. The expressions of HMGB1, RAGE, cyclin D1 and MMP-9 were downregulated while the expression of caspase-9 was upregulated by miR-218. Silencing HMGB1 increased the expression of RAGE, cyclin D1, MMP-9 but decreased the expression of caspase-9 in U251 and U87 cells. Co-transfection with pcHMGB1 and miR-218 significantly decreased the growth inhibition and increased the apoptosis of glioma cells while these effects were abolished in glioma cells co-transfected with HMGB1 siRNA and miR-218 inhibitor. In addition, co-transfection with pcHMGB1 and miR-218 inhibitor increased the invasiveness of U251 and U87 cells. These findings suggested that miR-218 may negatively regulate HMGB-mediated suppression of RAGE to regulate cell proliferation, apoptosis and invasion, and that intervention of miR-218-HMGB1-RAGE may be useful for developing potential clinical strategies. PMID:27725858

  9. MicroRNA-218 Increases the Sensitivity of Bladder Cancer to Cisplatin by Targeting Glut1

    Directory of Open Access Journals (Sweden)

    Peng Li

    2017-02-01

    Full Text Available Background/Aims: MicroRNA-218 (miR-218 is down-regulated in many malignancies that have been implicated in the regulation of diverse processes in cancer cells. However, the involvement of miR-218 in chemo-sensitivity to cisplatin and the precise mechanism of this action remained unknown in bladder cancer. Methods: qRT-PCR was used to detect miR-218 and its target Glut1 expression in bladder cancer cell lines T24 and EJ. CCK-8 method was utilized to measure the cell viability. IC 50 was calculated via a probit regression model. Glut1 was detected by western blotting for analysis of potential mechanism. Luciferase reporter assay was utilized to validate Glut1 as a direct target gene of miR-218. The intracellular level of GSH and ROS were determined using a commercial colorimetric assay kit and 2’, 7’-dichlorodihydro-fluorescein diacetate, respectively. Results: Over-expression of miR-218 significantly reduced the rate of glucose uptake and total level of GSH and enhanced the chemo-sensitivity of bladder cancer to cisplatin. Mechanistically, Glut1 was found to be a direct and functional target of miR-218. Up-regulation of Glut1 could restore chemo-resistance in T24 and EJ cells. On the contrary, knockdown of Glut1 could generate a similar effect as up-regulating the expression of miR-218. Conclusions: MiR-218 increases the sensitivity of bladder cancer to cisplatin by targeting Glut1. Restoration of miR-218 and repression of glut1 may provide a potential strategy to restore chemo-sensitivity in bladder cancer.

  10. microRNA-218 Inhibits Oxygen-induced Retinal Neovascularization via Reducing the Expression of Roundabout 1

    Directory of Open Access Journals (Sweden)

    Shuang Han

    2016-01-01

    Conclusions: Our experiments showed that restoration of miR-218 inhibited retinal angiogenesis via targeting Robo1. MiR-218 contributed to the inhibition of retinal angiogenesis and miR-218 might be a new therapeutic target for preventing RNV.

  11. 50 CFR 218.100 - Specified activity and specified geographical area.

    Science.gov (United States)

    2010-10-01

    ... Figure 1-1 in the Navy's application for MIRC), which is bounded by a pentagon with the following five..., dips, number of exercises) vary from those estimated in § 218.100(c), provided that the variation...

  12. MicroRNA-218在肿瘤中的研究进展

    Institute of Scientific and Technical Information of China (English)

    龙倩; 周航

    2016-01-01

    微小 RNA (microRNA ,miRNA)是一类内源性非编码小 RNA ,可调控不同基因的表达,从而改变细胞和生物体的表型。微小 RNA -218(MicroRNA -218,miR -218)的异常表达可导致细胞的增殖、分化、凋亡异常,与肿瘤的发生发展及预后密切相关。本文简述了 miR -218与女性生殖系统肿瘤、消化道肿瘤、颅内肿瘤、呼吸道肿瘤、泌尿生殖系肿瘤之间的关系,拟出 miR -218可能的调控机制,有助于为肿瘤的诊断和治疗提供新的靶点。%MicroRNAs (miRNAs) are small endogenous non - coding RNAs w hich can regulate gene expression differentlly ,and thus alter cell and biosome phenotype .Abnormal expression of microRNA - 218(miR - 218) can cause disorder of cell's differentiation ,proliferation ,apoptosis ,w hich is closely related to the occurrence and development of tumor .T his paper descripted the relationship between miR - 218 and tumors of female reproduc-tive system ,gastrointestinal tract ,brain ,respiratory and genitourinary ,and prepared some regulatory mechanisms to help provide new targets for cancer diagnosis and treatment .

  13. MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor.

    Directory of Open Access Journals (Sweden)

    Jun Tie

    2010-03-01

    Full Text Available MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and function of miR-218 in gastric cancer (GC metastasis. miR-218 expression is decreased along with the expression of one of its host genes, Slit3 in metastatic GC. However, Robo1, one of several Slit receptors, is negatively regulated by miR-218, thus establishing a negative feedback loop. Decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis. The restoration of miR-218 suppresses Robo1 expression and inhibits tumor cell invasion and metastasis in vitro and in vivo. Taken together, our results describe a Slit-miR-218-Robo1 regulatory circuit whose disruption may contribute to GC metastasis. Targeting miR-218 may provide a strategy for blocking tumor metastasis.

  14. An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211

    Energy Technology Data Exchange (ETDEWEB)

    O’Hara, Matthew J.; Krzysko, Anthony J.; Niver, Cynthia M.; Morrison, Samuel S.; Owsley, Stanley L.; Hamlin, Donald K.; Dorman, Eric F.; Scott Wilbur, D.

    2017-04-01

    Astatine-211 (211At) is a promising cyclotron-produced radionuclide being investigated for use in targeted alpha therapy of blood borne and metastatic cancers, as well as treatment of tumor remnants after surgical resections. The isolation of trace quantities of 211At, produced within several grams of a Bi metal cyclotron target, involves a complex, multi-step procedure: (1) Bi metal dissolution in strong HNO3, (2) distillation of the HNO3 to yield Bi salts containing 211At, (3) dissolution of the salts in strong HCl, (4) solvent extraction of 211At from bismuth salts with diisopropyl ether (DIPE), and (5) back-extraction of 211At from DIPE into NaOH, leading to a purified 211At product. Step (1) has been addressed first to begin the process of automating the onerous 211At isolation process. A computer-controlled Bi target dissolution system has been designed. The system performs in-line dissolution of Bi metal from the target assembly using an enclosed target dissolution block, routing the resulting solubilized 211At/Bi mixture to the subsequent process step. The primary parameters involved in Bi metal solubilization (HNO3 concentration and influent flow rate) were optimized prior to evaluation of the system performance on replicate cyclotron irradiated targets. The results indicate that the system performs reproducibly, having nearly quantitative release of 211At from irradiated targets, with cumulative 211At recoveries that follow a sigmoidal function. The predictable nature of the 211At release profile allows the user to tune the system to meet target processing requirements.

  15. 218 investments companies established by multinationals%跨国公司在中国现已设立218家投资性公司

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    according to data form the Ministry of foreign Trade and Economic Co-operation,multinationals have set up 218 investment companies in China,with registered capital to talling US$12.863 billion,US$12.084 billion from foreign investors.

  16. MiR-218 targets MeCP2 and inhibits heroin seeking behavior

    Science.gov (United States)

    Yan, Biao; Hu, Zhaoyang; Yao, Wenqing; Le, Qiumin; Xu, Bo; Liu, Xing; Ma, Lan

    2017-01-01

    MicroRNAs (miRNAs) are a class of evolutionarily conserved, 18–25 nucleotide non-coding sequences that post-transcriptionally regulate gene expression. Recent studies implicated their roles in the regulation of neuronal functions, such as learning, cognition and memory formation. Here we report that miR-218 inhibits heroin-induced behavioral plasticity. First, network propagation-based method was used to predict candidate miRNAs that played potential key roles in regulating drug addiction-related genes. Microarray screening was also carried out to identify miRNAs responding to chronic heroin administration in the nucleus accumbens (NAc). Among the collapsed miRNAs, top-ranked miR-218 was decreased after chronic exposure to heroin. Lentiviral overexpression of miR-218 in NAc could inhibit heroin-induced reinforcement in both conditioned place preference (CPP) test and heroin self-administration experiments. Luciferase activity assay indicated that miR-218 could regulate 3′ untranslated regions (3′ UTR) of multiple neuroplasticity-related genes and directly target methyl CpG binding protein 2 (Mecp2). Consistently, Mecp2308/y mice exhibited reduced heroin seeking behavior in CPP test. These data reveal a functional role of miR-218 and its target, MeCP2, in the regulation of heroin-induced behavioral plasticity. PMID:28074855

  17. A pri-miR-218 variant and risk of cervical carcinoma in Chinese women

    Directory of Open Access Journals (Sweden)

    Shi Ting-Yan

    2013-01-01

    Full Text Available Abstract Background MicroRNA (miRNA-related single nucleotide polymorphisms (SNPs may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few studies have investigated roles of miRNA-related SNPs in the etiology of cervical carcinoma. Methods In this case–control study of 1,584 cervical cancer cases and 1,394 cancer-free female controls, we investigated associations between two miR-218-related SNPs involved in the LAMB3-miR-218 pathway and the risk of cervical carcinoma in Eastern Chinese women. Results We found that the pri-miR-218 rs11134527 variant GG genotype was significantly associated with a decreased risk of cervical carcinoma compared with AA/AG genotypes (adjusted OR=0.77, 95% CI=0.63-0.95, P=0.015. However, this association was not observed for the miR-218 binding site SNP (rs2566 on LAMB3. Using the multifactor dimensionality reduction analysis, we observed some evidence of interactions of these two SNPs with other risk factors, especially age at primiparity and menopausal status, in the risk of cervical carcinoma. Conclusions The pri-miR-218 rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women. Larger, independent studies are warranted to validate our findings.

  18. B218 Weld Filler Wire Characterization for Al-Li Alloy 2195

    Science.gov (United States)

    Bjorkman, Gerry; Russell, Carolyn

    2000-01-01

    NASA Marshall Space Flight Center, Lockheed Martin Space Systems- Michoud Operations, and McCook Metals have developed an aluminum-copper weld filler wire for fusion welding aluminum lithium alloy 2195. The aluminum-copper based weld filler wire has been identified as B218, a McCook Metals designation. B218 is the result of six years of weld filler wire development funded by NASA, Lockheed Martin, and McCook Metals. The filler wire chemistry was developed to produce enhanced 2195 weld and repair weld mechanical properties over the 4043 aluminum-silicon weld filler wire, which is currently used to weld 2195 on the Super Lightweight External Tank for the NASA Space Shuttle Program. An initial characterization was performed consisting of a repair weld evaluation using B218 and 4043 weld filler wires. The testing involved room temperature and cryogenic repair weld tensile testing along with fracture toughness testing. From the testing, B218 weld filler wire produce enhanced repair weld tensile strength, ductility, and fracture properties over 4043. B218 weld filler wire has proved to be a superior weld filler wire for welding aluminum lithium alloy 2195 over 4043.

  19. miR-218 expression in osteosarcoma tissues and its effect on cell growth in osteosarcoma cells

    Institute of Scientific and Technical Information of China (English)

    Hong-Tai Wang; Ai-Gang Liu; Dao-Shu Luo; Zhang-Nan Zhou; Hong-Guang Lin; Rong-Zi Chen; Jin-Shui He; Kun Chen

    2014-01-01

    Objective:To investigate the expression of miR-218 and its clinical significance in osteosarcoma tissues and explore its effect on proliferation and apoptosis in osteosarcoma cells.Methods:miR-218 expression was detected in76 samples of surgically resected osteosarcoma and matched normal tumor-adjacent tissues using quantitative reverse transcription polymerase chain reaction (qRT-PCR).MiR-218 was over-expressed by exogenous miR-218 plasmids inSaos-2 cells, and thenBrdU cell proliferation assay and flow cytometry were used to determine cell proliferation and apoptosis.Results:The expression of miR-218 in osteosarcoma tissues was significantly lower than those in normal tumor-adjacent tissues(t=8.735,P<0.001).MiR-218 expression in tumor tissues was significantly correlated with tumor size(χ2=5.380,P=0.020), clinical stage (χ2=6.692,P=0.010) and distant metastasis(χ2=4.180,P=0.041).MiR-218 was obviously over-expressed by exogenous miR-218 plasmids(t=19.42,P<0.001), and miR-218 overexpression significantly reduced cell proliferation(t=9.045,P<0.001) and induced apoptosis(t=12.38, P<0.001) inSaos-2 cells.Conclusions:The low-expression of miR-218 is correlated with the poor clinicopathological features in osteosarcoma.Moreover, miR-218 overexpression reduces cancer cell proliferation and induces apoptosis inSaos-2 cells, suggesting that miR-218 may play a key role in the progression of human osteosarcoma.

  20. 218例巨大胎儿相关因素分析%An analysis of related factors contributing to 218 somatomegaly fetuses

    Institute of Scientific and Technical Information of China (English)

    杨彬

    2000-01-01

    @@ 近年来发现巨大胎儿发生率有上升趋势,提高产前诊断水平是降低巨大胎儿分娩并发症的关键,因此,本文对我院近2年来分娩的218例巨大胎儿进行分析,了解巨大胎儿形成的相关因素.

  1. MicroRNA-218 inhibits the proliferation and metastasis of esophageal squamous cell carcinoma cells by targeting BMI1.

    Science.gov (United States)

    Wang, Ting; Chen, Tengfei; Niu, Hua; Li, Chang; Xu, Chun; Li, Yuanyuan; Huang, Rui; Zhao, Jun; Wu, Shuyan

    2015-07-01

    MicroRNAs (miRNAs or miRs) play a pivotal role in esophageal carcinogenesis either as oncogenes or as tumor suppressor genes. In the present study, we found that the expression level of miR-218 was significantly reduced in esophageal squamous cell carcinoma (ESCC) tissues and ESCC cell lines. Moreover, its expression was found to correlate with the clinicopathological stage of ESCC; miR-218 expression was lower in the stage III tissue samples than in the stage I and II tissue samples. Furthermore, the decreased expression of miR-218 was found to be associated with an enhanced ESCC cell proliferation and metastasis. Western blot analysis and luciferase reporter assay revealed that miR-218 decreased BMI1 expression by binding to the putative binding sites in its 3'-untranslated region (3'-UTR). The BMI1 mRNA expression levels were markedly increased and negatively correlated with the miR-218 expression level in the ESCC tissues. Functional analyses revealed that the restoration of miR-218 expression inhibited ESCC cell proliferation, migration and invasion and promoted apoptosis. The knockdown of BMI1 by siRNA showed the same phenocopy as the effect of miR-218 on ESCC cells, indicating that BMI1 was a major target of miR-218. In the present study, our findings confirm miR-218 as a tumor suppressor and identify BMI1 as a novel target of miR-218 in ESCC. Therefore, miR-218 may prove to be a useful biomarker for monitoring the initiation and development of ESCC, and may thus be an effective therapeutic target in ESCC.

  2. 7 CFR 1951.218 - Use of Rural Development loans and grants for other purposes.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Use of Rural Development loans and grants for other... Servicing of Community and Direct Business Programs Loans and Grants § 1951.218 Use of Rural Development... the Consolidated Farm and Rural Development Act, as amended; and (3) Satisfies such...

  3. 20 CFR 218.16 - When a surviving divorced spouse annuity begins.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When a surviving divorced spouse annuity... RAILROAD RETIREMENT ACT ANNUITY BEGINNING AND ENDING DATES When an Annuity Begins § 218.16 When a surviving divorced spouse annuity begins. (a) A surviving divorced spouse annuity begins on the later of either...

  4. China Gold Group Invested 2.18 billion Yuan to Buy Gold Mine

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>Ministry of Finance recently proclaimed that China Gold Group has invested 2.18 billion Yuan to gain the exploration right on the Yang- shan gold mine in Wen County,Gansu Prov- ince.Yangshan is located at the place where

  5. 24 CFR 5.218 - Penalties for failing to disclose and verify Social Security and Employer Identification Numbers.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Penalties for failing to disclose and verify Social Security and Employer Identification Numbers. 5.218 Section 5.218 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development GENERAL HUD...

  6. microRNA-218 Inhibits Oxygen-induced Retinal Neovascularization via Reducing the Expression of Roundabout 1

    Institute of Scientific and Technical Information of China (English)

    Shuang Han; Yi-Chun Kong; Bei Sun; Quan-Hong Han; Ying Chen; Yu-Chuan Wang

    2016-01-01

    Background:The mechanisms of pathological retinal neovascularization (RNV) remain unknown.Several microRNAs were reported to be involved in the process of RNV.Oxygen-induced retinopathy (OIR) is a useful model to investigate RNV.Our present work explored the expression and the role of microRNA-128 (miR-218) in oxygen-induced RNV.Methods:OIR was used to establish RNV model.The expression level ofmiR-218 in the retina from OIR mice was assessed by quantitative real-time reverse transcfiptase polymerase chain reaction.Fluorescein angiography was performed in retinae of OIR mice,and RNV was quantified by hematoxylin and eosin staining to evaluate the effect of pCDH-CMV-miR-218 intravitreal injection on RNV in OIR mice.Roundabout 1 (Robo 1) expression was detected by Western blotting in mouse retinal vascular endothelial cells expressing a high or low level ofmiR-218 and retinal tissues from OIR mice.Cell migration was evaluated by scratch wound assay.Results:In OIR mice,the expression level of miR-218 was significantly down-regulated (P =0.006).Retinal Robo1 expression was significantly increased at both mRNA and protein levels (P =0.001,0.008;respectively),miR-218 intravitreal injection inhibited retinal angiogenesis in OIR mice,and the restoration of miR-218 in retina led to down-regulation of Robo 1.Conclusions:Our experiments showed that restoration of miR-218 inhibited retinal angiogenesis via targeting Robo 1.MiR-218 contributed to the inhibition of retinal angiogenesis and miR-218 might be a new therapeutic target for preventing RNV.

  7. miR-218 suppresses tumor growth and enhances the chemosensitivity of esophageal squamous cell carcinoma to cisplatin.

    Science.gov (United States)

    Tian, Hang; Hou, Lei; Xiong, Yu-Mei; Huang, Jun-Xiang; She, Ying-Jun; Bi, Xiao-Bao; Song, Xing-Rong

    2015-02-01

    A growing body of evidence suggests that microRNA-218 (miR-218) acts as a tumor suppressor and is involved in tumor progression, development and metastasis and confers sensitivity to certain chemotherapeutic drugs in several types of cancer. However, our knowledge concerning the exact roles played by miR-218 in esophageal squamous cell carcinoma (ESCC) and the underlying molecular mechanisms remain relatively unclear. Thus, the aims of this study were to detect the expression of miR-218 in human ESCC tissues and explore its effects on the biological features and chemosensitivity to cisplatin (CDDP) in an ESCC cell line (Eca109), so as to provide new insights for ESCC treatment. Here, we found increased expression of miR-218 in the ESCC tissues compared with that in the matched non-tumor tissues, and its expression level was correlated with key pathological characteristics including clinical stage, tumor depth and metastasis. We also found that enforced expression of miR-218 significantly decreased cell proliferation, colony formation, migration and invasion, induced cell apoptosis and arrested the cell cycle in the G0/G1 phase, as well as suppressed tumor growth in a nude mouse model. In addition, our results showed that miR-218 mimics increased the sensitivity to the antitumor effect of CDDP in the human Eca109 cells. Importantly, this study also showed that miR-218 regulated the expression of phosphorylated PI3K, AKT and mTOR, which may contribute to suppressed tumor growth of ESCC and enhanced sensitivity of ESCC cells. These findings suggest that miR-218 is a potential therapeutic agent for the treatment of ESCC.

  8. China March Apparel Retail Sales Report Retail Sales Vaule + 21.8% Y/Y

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Total retail sales value in major department stores picked up sharply in Mar. 2011, rising by about 25.6 percent y/y to CNY 46.63 billion, according to Na-tion Commercial Information Center of China. Of which, retail sales value of apparel products in major department stores increased 21.8 per cent y/y to CNY 11.89 billion, 3.8% lower than national average. For volume, retail sales volum

  9. An analysis of clinical characteristics,etiologies and prognosis of 218 patients with infective endocarditis

    Institute of Scientific and Technical Information of China (English)

    谢红梅

    2014-01-01

    Objective To describe the profile of patients with infective endocarditis(IE)and assess prognostic factors of IE.Methods Clinical and etiology data of 218 patients with IE were collected retrospectively from January 2011to January 2013.The distribution and antimicrobial susceptibilities of pathogens causing IE were evaluated.Prognostic factors associated with IE were determined by univariate and multivariate regression analysis.Results

  10. 老年贫血218例病因分析%Etiopathogenisis analysis of 218 cases of anemia in the elderly

    Institute of Scientific and Technical Information of China (English)

    高丽霞; 吴克雄; 冀红红; 谢静荣

    2010-01-01

    目的 探讨老年贫血的诊断特点.方法 分析218例老年贫血病例的血常规、骨髓红系增生情况、骨髓形态学及病理学诊断、病因诊断等项目为观察指标.结果 218例老年贫血病例中,男性数量稍多于女性,中位年龄67.9岁.中重度贫血占绝大多数,形态学上以小细胞性贫血比例最高,占42.66%;其次为正细胞性贫血,占35.85%.骨髓红系增生活跃以上者占82.35%;缺铁性贫血为老年贫血最常见的病种(39.44%),其次为巨幼细胞性贫血、骨髓增生异常综合征.缺铁性贫血的病因中摄入不足最常见,占25.66%,肿瘤、溃疡及胃大部切除术后也较多见.骨髓增生异常综合征、巨幼细胞性贫血和慢性再生障碍性贫血为老年全血细胞减少病例的常见病种.结论 老年人属弱势群体,老年贫血病例中缺铁性贫血和营养不良性贫血比例高.%Objective To explore the diagnostic characteristics of anemia in the elderly. Methods To measure and analyze the eric status of bone marrow, diagnosis according to morphology and biopsy of bone marrow, and etiology of anemia(IDA) in 218 cases of anemia in the aged. Results In these 218 cases male patients were slightly more than female patients. Median age was 68.9. Ratio of cases with macrocytic anemia was the highest(42.66%), ratio of cases with active erythropoietic status was 82. 35%. Iron deficiency anemia was the most common anemia in the elderly(39. 44%), and megaloblastic anemia and myelodysplastic syndrome (MDS) were also frequent. Insufficient ingestion was the most common cause of IDA(25.66 %),and tumors,digestive ulcers and postgastrectomy were also the common causes. MDS,megaloblastic anemia and chronic aplastic anemia(CAA) were the common anemia in geriatric population with pancytopenia. Conclusions Geriatric population is the fragile group. Ratio of cases with anemia due to IDA and malnutrition is high in cases of anemia in the elderly.

  11. MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma.

    Directory of Open Access Journals (Sweden)

    Morgan R Davidson

    Full Text Available MicroRNAs (miRNAs are a family of small, non-coding RNA species functioning as negative regulators of multiple target genes including tumour suppressor genes and oncogenes. Many miRNA gene loci are located within cancer-associated genomic regions. To identify potential new amplified oncogenic and/or deleted tumour suppressing miRNAs in lung cancer, we inferred miRNA gene dosage from high dimensional arrayCGH data. From miRBase v9.0 (http://microrna.sanger.ac.uk, 474 human miRNA genes were physically mapped to regions of chromosomal loss or gain identified from a high-resolution genome-wide arrayCGH study of 132 primary non-small cell lung cancers (NSCLCs (a training set of 60 squamous cell carcinomas and 72 adenocarcinomas. MiRNAs were selected as candidates if their immediately flanking probes or host gene were deleted or amplified in at least 25% of primary tumours using both Analysis of Copy Errors algorithm and fold change (≥ ± 1.2 analyses. Using these criteria, 97 miRNAs mapped to regions of aberrant copy number. Analysis of three independent published lung cancer arrayCGH datasets confirmed that 22 of these miRNA loci showed directionally concordant copy number variation. MiR-218, encoded on 4p15.31 and 5q35.1 within two host genes (SLIT2 and SLIT3, in a region of copy number loss, was selected as a priority candidate for follow-up as it is reported as underexpressed in lung cancer. We confirmed decreased expression of mature miR-218 and its host genes by qRT-PCR in 39 NSCLCs relative to normal lung tissue. This downregulation of miR-218 was found to be associated with a history of cigarette smoking, but not human papilloma virus. Thus, we show for the first time that putative lung cancer-associated miRNAs can be identified from genome-wide arrayCGH datasets using a bioinformatics mapping approach, and report that miR-218 is a strong candidate tumour suppressing miRNA potentially involved in lung cancer.

  12. Motor neuron-expressed microRNAs 218 and their enhancers are nested within introns of Slit2/3 genes.

    Science.gov (United States)

    Punnamoottil, Beena; Rinkwitz, Silke; Giacomotto, Jean; Svahn, Adam J; Becker, Thomas S

    2015-05-01

    miR218-1 and miR218-2 are embedded in introns of SLIT2 and SLIT3, respectively, an arrangement conserved throughout vertebrate genomes. Both miR218 genes are predicted to be transcribed in the same orientation as their host genes and were assumed to be spliced from Slit2/3 primary transcripts. In zebrafish miR218 is active in cranial nerve motor nuclei and spinal cord motor neurons, while slit2 and slit3 are expressed predominantly in the midline. This differential expression pattern suggested independent regulation of miR218 genes by distinct enhancers. We tested conserved noncoding elements for regulatory activity by reporter gene transgenesis in zebrafish. Two human enhancers, 76 kb and 130 kb distant from miR218-2, were identified that drove GFP expression in zebrafish in an almost complete miR218 expression pattern. In the zebrafish slit3 locus, two enhancers with identical activity were discovered. In human SLIT2 one enhancer 52 kb upstream of miR218-1 drove an expression pattern very similar to the enhancers of miR218-2. This establishes that miR218-1/-2 regulatory units are nested within SLIT2/3 and that they are duplicates of an ancestral single locus. Due to the strong activity of the enhancers, unique transgenic lines were created that facilitate morphological and gene functional genetic experiments in motor neurons.

  13. LEEP in the Treatment of Cervical Lesions in 218 Cases of Clinical Observation%LEEP治疗宫颈病变218例临床观察

    Institute of Scientific and Technical Information of China (English)

    刘淑芬

    2013-01-01

      目的:观察 LEEP 治疗宫颈病变的临床疗效.方法:对本院妇科门诊发现的各种宫颈病变218例患者,采用 LEEP 宫颈环形电切术诊治,切除组织全部送病检.结果:术后2个月慢性宫颈炎96.43%完全愈合,宫颈湿疣100%愈合,CIN Ⅰ~Ⅱ100%愈合,CIN Ⅲ46.15%愈合,2例持续 CIN Ⅲ行全子宫切除术.结论:LEEP 宫颈环形电切术是目前诊治宫颈病变的理想方法,对早期诊断宫颈原位癌具有较高的临床价值,能有效阻断原位癌病变发展为浸润癌.%Objective:To observe on LEEP in treatment of cervical disease clinical curative effect.Method:The gynecological clinic was found in the 218 cases of various types of cervical lesion patients,using LEEP cervical loop electrosurgical excision procedure for cervical disease diagnosis and treatment,the removal of the tissue were all sent to the pathology examination.Result:2 months later,chronic cervicitis patients 96.43% achieved complete healing,cervical condyloma acuminatum lesions 100% patients achieved healing,cervical intraepithelial neoplasia Ⅰ~ Ⅱ 100% patients achieved healing,cervical intraepithelial neoplasia Ⅲ 46.15% patients achieved healing,2 cases because of persistent cervical intraepithelial neoplasia lesions Ⅲ for total hysterectomy. Conclusion:LEEP is currently the diagnosis and treatment of cervical lesions in the ideal method,for the early diagnosis of cervical carcinoma in situ has high clinical value,can effectively block the carcinoma in situ lesions progress to invasive cancer.

  14. Hemiconvulsion-hemiplegia-epilepsy syndrome associated with CACNA1A S218L mutation.

    Science.gov (United States)

    Yamazaki, Sawako; Ikeno, Kanju; Abe, Tokinari; Tohyama, Jun; Adachi, Yoshiki

    2011-09-01

    Hemiconvulsion-hemiplegia-epilepsy syndrome involves sudden and prolonged unilateral seizures, followed by transient or permanent hemiplegia and epilepsy during infancy or early childhood. Some patients with familial hemiplegic migraine and demonstrating the S218L mutation in CACNA1A experience severe attacks with unilateral cerebral edema after trivial head trauma. We report on a 5-year-old Japanese girl presenting with hemiconvulsion-hemiplegia-epilepsy syndrome after infection with parvovirus B19. Magnetic resonance imaging performed 2 days after admission revealed cerebellar atrophy and marked hyperintensity in the left hemisphere on T(2)-weighted and diffusion-weighted imaging. Magnetic resonance angiography performed 7 days after admission demonstrated obliteration of the left proximal middle cerebral artery in the acute phase. However, this finding was not evident on brain angiography performed 25 hours after magnetic resonance angiography. Genetic analysis of familial hemiplegic migraine revealed a heterozygous S218L mutation in CACNA1A. Taken together, these results suggest that vasospasms of cerebral vascular smooth muscle, with possible cortical spreading depression, may have caused the hemiconvulsions and hemiplegia in the left hemisphere. This case report is the first, to the best of our knowledge, to associate CACNA1A with hemiconvulsion-hemiplegia-epilepsy syndrome and familial hemiplegic migraine, and to suggest that similar pathogenic mechanisms may underlie these two disorders.

  15. ADAM9 up-regulates N-cadherin via miR-218 suppression in lung adenocarcinoma cells.

    Directory of Open Access Journals (Sweden)

    Yuh-Pyng Sher

    Full Text Available Lung cancer is the leading cause of cancer death worldwide, and brain metastasis is a major cause of morbidity and mortality in lung cancer. CDH2 (N-cadherin, a mesenchymal marker of the epithelial-mesenchymal transition and ADAM9 (a type I transmembrane protein are related to lung cancer brain metastasis; however, it is unclear how they interact to mediate this metastasis. Because microRNAs regulate many biological functions and disease processes (e.g., cancer by down-regulating their target genes, microRNA microarrays were used to identify ADAM9-regulated miRNAs that target CDH2 in aggressive lung cancer cells. Luciferase assays and western blot analysis showed that CDH2 is a target gene of miR-218. MiR-218 was generated from pri-mir-218-1, which is located in SLIT2, in non-invasive lung adenocarcinoma cells, whereas its expression was inhibited in aggressive lung adenocarcinoma. The down-regulation of ADAM9 up-regulated SLIT2 and miR-218, thus down-regulating CDH2 expression. This study revealed that ADAM9 activates CDH2 through the release of miR-218 inhibition on CDH2 in lung adenocarcinoma.

  16. 手术治疗拇外翻218例的临床症状分析%Clinical Symptoms of 218 Patients with Hallux Valgus Undergoing Operation

    Institute of Scientific and Technical Information of China (English)

    黄加张; 马昕; 王旭; 张超; 顾湘杰; 陈立

    2011-01-01

    Objective To analyze presenting symptoms of hallux valgus and the relationship between presenting symptoms and hallvu valgus stage. Methods All of 218 patients (291 feet) with hallux valgus admitted to Huashan Hospital in 2004~2009 were analyzed. According to presenting symptoms: bunion, less toe deformity, forefoot planter pain. According to X-ray assessment: mild, moderate or severe hallux valgus. Results Many kinds of presenting symptoms were reported:27 feet with bunion, 47 feet with less toe deformity, 14 feet with forefoot planter pain, 205 feet with two or three presenting symptoms. Mild, moderate and severe hallux valgus were 58, 108 and 125 feet respectively. The magnitude of hallux valgus deformity was not related with bunion or fore planter pain (P ≥0.05). Severe hallux valgus was significantly related with less toe deformity (P <0.05). Two or three presenting symptoms were significantly related with moderate or severe hallux valgus (P<0.05). Presenting symptoms of moderate and severe hallux valgus were not significantly related (P ≥0.05). Conclusion There are many presenting symptoms of hallux valgus, each of them with its own particular pathogenesis and problems. Different procedures should depend on not only X-ray assessment but also presenting symptoms and other deformities.%目的 探讨拇外翻患者就诊手术原因及与分度的关系.方法 收集2004年1月~2009年8月复旦大学附属华山医院手术治疗拇外翻218例(291足)的临床资料,根据临床症状分为四类:单纯跖骨头内侧疼痛,单纯小趾畸形,单纯前足胼胝疼痛.根据X线测量拇外翻角、跖骨间角分为轻度、中度、重度.结果 拇外翻患者就诊原因多种多样,其中单纯拇囊炎疼痛27足,单纯小趾畸形疼痛45足,单纯前足疼痛14足,有两项或两项以上症状205足.根据X线分型:轻度拇外翻58足,中度拇外翻108足,重度拇外翻125足.单纯拇囊炎疼痛、单纯前足疼痛与拇外

  17. Numerical modeling of Po-218 deposition in a physiologically realistic lung bifurcation model

    Science.gov (United States)

    Mously-Soroujy, Khalid Ahmad

    Experimental data for lung bifurcations reveals complex geometries and distinct asymmetrical characteristic, which affects the localized distribution of particles deposited in the lung. This study is based on recently published numerical results for a symmetric physiological realistic bifurcation geometry Heistracher and Hofmann (1995) which has been extended here to the case of a asymmetric geometry. The asymmetric PRB model was used to study the flow field and the deposition of ultrafine particles for inspiratory and expiratory conditions. In the present study, we investigated the effect of different flow rates, representing human activity and deposition of different ultrafine particles representing radon daughter (Po-218), in the PRB model. Numerical results were compared with the limited available experimental and numerical data. The fluid dynamic computer program FIDAP was used for this purpose.

  18. Detection of PRRSV in 218 field samples using six molecular methods: What we are looking for?

    DEFF Research Database (Denmark)

    Toplak, Ivan; Štukelj, Marina; Gracieux, Patrice

    2012-01-01

    Objectives The purpose of this study was to determine the sensitivity and the specificity of six molecular methods used for the detection of porcine reproductive and respiratory syndrome virus (PRRSV). Methods 218 field samples (serum, tissues) were collected between 2009 and 2011 from 50 PRRSV...... positive and 45 negative pig herds from Slovenia. Total viral RNA was extracted from original samples and stored in aliquots at -70 °C until analysis. RT-PCR and direct sequencing of positive samples was performed as described previously (Toplak et al., 2012). All field samples were analyzed with five...... commercial real-time RT-PCR kits (named as kit A to E) according to the instructions of producer. Results According to determined 258 nucleotides long sequences (ORF7) 102 PRRSV samples belong to Type I (identification of 12 different lineages of EU subtype 1 (a=1, b=8, c=1, d=1, e=61, f=8, g=2, h=4, i=3, j...

  19. Malignant transformation of oral leukoplakia: a retrospective cohort study of 218 Chinese patients

    Directory of Open Access Journals (Sweden)

    Zhou Zeng-Tong

    2010-12-01

    Full Text Available Abstract Background Oral leukoplakia (OL is the best-known potentially malignant disorder. A new binary system to grade dysplasia was proposed by WHO, but the biological significance in predicting malignant transformation risk is unknown. The objective of this study is to estimate the rate of malignant transformation in a long-term follow-up cohort, explore the usefulness of the new binary system of grading dysplasia and identify significant risk factors of OL malignant transformation in China. Methods A total of 218 patients with clinical and histopathologic diagnosis of OL were retrospectively reviewed. They were selected among all archived files at the Department of Oral Mucosal Diseases, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. The mean follow-up period was 5.3 years. Results Among 218 cases, 39 (17.9% OL patients developed oral cancer, with a mean duration of 5.2 years. Cox regression analysis revealed that dysplasia was an independent risk factor for OL malignant transformation, but age, gender, lesion site, diet habit, smoking and ethanol intake were not risk factors. High-risk dysplastic OL was associated with a 4.57-fold (95% confidence interval, 2.36-8.84; P Conclusions The new binary system's function in predicting OL malignant transformation risk was investigated in this survey. The utilization of high-risk dysplasia as a significant indicator for evaluating malignant transformation risk in patients with OL was suggested, which may be helpful to guide treatment selection in clinical practice.

  20. Spitzer Observations Confirm and Rescue the Habitable-Zone Super-Earth K2-18b for Future Characterization

    CERN Document Server

    Benneke, Björn; Petigura, Erik; Knutson, Heather; Dressing, Courtney; Crossfield, Ian J M; Schlieder, Joshua E; Livingston, John; Beichman, Charles; Christiansen, Jessie; Krick, Jessica; Gorjian, Varoujan; Howard, Andrew W; Sinukoff, Evan; Ciardi, David R; Akeson, Rachel L

    2016-01-01

    The recent detections of two transit events attributed to the super-Earth candidate K2-18b have provided the unprecedented prospect of spectroscopically studying a habitable-zone planet outside the Solar System. Orbiting a nearby M2.5 dwarf and receiving virtually the same stellar insolation as Earth, K2-18b would be a prime candidate for the first detailed atmospheric characterization of a habitable-zone exoplanet using HST and JWST. Here, we report the detection of a third transit of K2-18b near the predicted transit time using the Spitzer Space Telescope. The Spitzer detection demonstrates the periodic nature of the two transit events discovered by K2, confirming that K2-18 is indeed orbited by a super-Earth in a 33-day orbit and ruling out the alternative scenario of two similarly-sized, long-period planets transiting only once within the 75-day K2 observation. We also find, however, that the transit event detected by Spitzer occurred 1.85 hours (7-sigma) before the predicted transit time. Our joint analy...

  1. Bacillus velezensis RC 218 as a biocontrol agent to reduce Fusarium head blight and deoxynivalenol accumulation in wheat

    Science.gov (United States)

    Bacillus velezensis RC 218 was originally isolated for the anthers of wheat as a potential antagonist of Fusarium graminearium, the causal agent of Fusarium head blight. It was demonstrated to have antagonist activity against the plant pathogen with in vitro and greenhouse assays. The current study ...

  2. Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutation

    NARCIS (Netherlands)

    Stam, A. H.; Luijckx, G-J; Poll-The, B. T.; Ginjaar, I. B.; Frants, R. R.; Haan, J.; Ferrari, M. D.; Terwindt, G. M.; van den Maagdenberg, A. M. J. M.

    2009-01-01

    Objective: To study the clinical spectrum of CACNA1A S218L mutation carriers with special attention to "early seizures and cerebral oedema after trivial head trauma (ESCEATHT)", a combination of symptoms which resembles the "juvenile head trauma syndrome". Patients and methods: In two patients with

  3. Association between pri-miR-218 polymorphism and risk of hepatocellular carcinoma in a Han Chinese population.

    Science.gov (United States)

    Zhang, Lu-Shun; Liang, Wei-Bo; Gao, Lin-Bo; Li, Hong-Yu; Li, Li-Juan; Chen, Peng-Yu; Liu, Yun; Chen, Tian-Yi; Han, Jun-Ge; Wei, Yong-Gang; Zhang, Lin

    2012-05-01

    MicroRNAs are noncoding RNA molecules of 18-25 nucleotides that regulate gene expression at the post-transcriptional level. The aim of this study was to investigate whether pri-miR-218 rs11134527 A/G polymorphism influences the risk of hepatocellular carcinoma (HCC) or not. pri-miR-218 rs11134527 A/G was genotyped in 302 HCC patients and 513 control subjects using the polymerase chain reaction-restriction fragment length polymorphism assay. The AG genotype of pri-miR-218 rs11134527 A/G was associated with family history (p=0.018, odds ratio [OR]=2.96, 95% confidence interval [CI]: 1.16-7.56) and elevated serum α-fetoprotein (serum alpha-fetoprotein [AFP]) levels (≥20 ng/mL; p=0.009, OR=1.92, 95% CI: 1.17-3.14) in HCC patients. These findings suggested that the AG genotype of pri-miR-218 rs11134527 might relate to genetic predisposition and be involved in regulating the expression of AFP in Chinese HCC patients.

  4. 77 FR 69503 - Comment Request for Information Collection on the ETA 218, Benefit Rights and Experience Report...

    Science.gov (United States)

    2012-11-19

    ... Employment and Training Administration Comment Request for Information Collection on the ETA 218, Benefit... (ETA), Labor. ACTION: Notice. SUMMARY: The Department of Labor (Department), as part of its continuing... requirements on respondents can be properly assessed. Currently, ETA is soliciting comments concerning...

  5. Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutation

    NARCIS (Netherlands)

    A.H. Stam; G.J. Luijckx; B.T. Poll-Thé; I.B. Ginjaar; R.R. Frants; J. Haan; M.D. Ferrari; G.M. Terwindt; A.M.J.M. van den Maagdenberg

    2009-01-01

    OBJECTIVE: To study the clinical spectrum of CACNA1A S218L mutation carriers with special attention to "early seizures and cerebral oedema after trivial head trauma (ESCEATHT)", a combination of symptoms which resembles the "juvenile head trauma syndrome". PATIENTS AND METHODS: In two patients with

  6. Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-Convergence on axonal guidance

    DEFF Research Database (Denmark)

    Kaalund, Sanne Simone; Venø, Morten T; Bak, Mads

    2014-01-01

    R-204 and miR-218 showed strong changes in expression during fetal development of the hippocampus in pigs, and we identified four target genes, involved in axonal guidance and synaptic plasticity, ROBO1, GRM1, SLC1A2, and GNAI2, as bona fide targets of miR-218. GRM1 was also shown to be a direct target...

  7. Cooked oatmeal consumption is associated with better diet quality, better nutrient intakes, and reduced risk for central adiposity and obesity in Children 2-18 years

    Science.gov (United States)

    The objective of this study was to assess the association between oatmeal consumption and nutrient intake, diet quality, and weight/adiposity of children aged 2-18. A nationally representative sample of children aged 2-18 (N=14,690) participating in National Health and Nutrition Examination Survey 2...

  8. MicroRNA 218 mediates the effects of Tbx5a over-expression on zebrafish heart development.

    Directory of Open Access Journals (Sweden)

    Elena Chiavacci

    Full Text Available tbx5, a member of the T-box gene family, encodes one of the key transcription factors mediating vertebrate heart development. Tbx5 function in heart development appears to be exquisitely sensitive to gene dosage, since both haploinsufficiency and gene duplication generate the cardiac abnormalities associated with Holt-Oram syndrome (HOS, a highly penetrant autosomal dominant disease characterized by congenital heart defects of varying severity and upper limb malformation. It is suggested that tight integration of microRNAs and transcription factors into the cardiac genetic circuitry provides a rich and robust array of regulatory interactions to control cardiac gene expression. Based on these considerations, we performed an in silico screening to identify microRNAs embedded in genes highly sensitive to Tbx5 dosage. Among the identified microRNAs, we focused our attention on miR-218-1 that, together with its host gene, slit2, is involved in heart development. We found correlated expression of tbx5 and miR-218 during cardiomyocyte differentiation of mouse P19CL6 cells. In zebrafish embryos, we show that both Tbx5 and miR-218 dysregulation have a severe impact on heart development, affecting early heart morphogenesis. Interestingly, down-regulation of miR-218 is able to rescue the heart defects generated by tbx5 over-expression supporting the notion that miR-218 is a crucial mediator of Tbx5 in heart development and suggesting its possible involvement in the onset of heart malformations.

  9. Spitzer Observations Confirm and Rescue the Habitable-zone Super-Earth K2-18b for Future Characterization

    Science.gov (United States)

    Benneke, Björn; Werner, Michael; Petigura, Erik; Knutson, Heather; Dressing, Courtney; Crossfield, Ian J. M.; Schlieder, Joshua E.; Livingston, John; Beichman, Charles; Christiansen, Jessie; Krick, Jessica; Gorjian, Varoujan; Howard, Andrew W.; Sinukoff, Evan; Ciardi, David R.; Akeson, Rachel L.

    2017-01-01

    The recent detections of two transit events attributed to the super-Earth candidate K2-18b have provided the unprecedented prospect of spectroscopically studying a habitable-zone planet outside the solar system. Orbiting a nearby M2.5 dwarf and receiving virtually the same stellar insolation as Earth, K2-18b would be a prime candidate for the first detailed atmospheric characterization of a habitable-zone exoplanet using the Hubble Space Telescope (HST)and James Webb Space Telescope (JWST). Here, we report the detection of a third transit of K2-18b near the predicted transit time using the Spitzer Space Telescope. The Spitzer detection demonstrates the periodic nature of the two transit events discovered by K2, confirming that K2-18 is indeed orbited by a super-Earth in a 33 day orbit, ruling out the alternative scenario of two similarly sized, long-period planets transiting only once within the 75 day Kepler Space Telescope (K2) observation. We also find, however, that the transit event detected by Spitzer occurred 1.85 hr (7σ ) before the predicted transit time. Our joint analysis of the Spitzer and K2 photometry reveals that this early occurrence of the transit is not caused by transit timing variations, but the result of an inaccurate ephemeris due to a previously undetected data anomaly in the K2 photometry. We refit the ephemeris and find that K2-18b would have been lost for future atmospheric characterizations with HST and JWST if we had not secured its ephemeris shortly after the discovery. We caution that immediate follow-up observations as presented here will also be critical for confirming and securing future planets discovered by the Transiting Exoplanet Survey Satellite (TESS), in particular if only two transit events are covered by the relatively short 27-day TESS campaigns.

  10. The microRNA-218 and ROBO-1 signaling axis correlates with the lymphatic metastasis of pancreatic cancer.

    Science.gov (United States)

    He, Hang; Di, Yang; Liang, Minrui; Yang, Feng; Yao, Lie; Hao, Sijie; Li, Ji; Jiang, Yongjian; Jin, Chen; Fu, Deliang

    2013-08-01

    Pancreatic cancer is known for its poor prognosis and early lymphatic metastasis is a notable characteristic. microRNAs (miRNAs) have been shown to be involved in the initiation and progression of pancreatic cancer. We, therefore, established a screening strategy to find miRNAs related to the lymphatic metastasis of pancreatic cancer and explored the target genes of miRNAs. miRNA array profiles were analyzed in tissue samples [pancreatic ductal adenocarcinoma (PDAC) and matched adjacent benign tissues (MAT)] and cell lines (BxPC-3-LN and BxPC-3). Combined analysis of profiling data from tissue samples and cell lines was used to identify miRNAs related to the lymphatic metastasis of pancreatic cancer. The expression levels of miRNAs were confirmed by real‑time reverse transcription PCR (RT-PCR) in tissue samples and cell lines. The correlation between miRNAs and clinicopathological characteristics was investigated. The expression features of miRNAs in pancreatic cancer, precursor lesions and metastatic lymph nodes were characterized by in situ hybridization (ISH). Predicted target genes of miRNAs were validated by RT-PCR and the protein levels of target genes were revealed by western blotting. Seventy and 63 miRNAs were differentially expressed in pancreatic cancer and BxPC-3-LN, compared to MAT and BxPC-3, respectively. Combined microarray analysis found 4 co-differentially expressed miRNAs (miRNA-663, miRNA-145, miRNA-218 and let-7) related to the lymphatic metastasis of pancreatic cancer. miRNA-218 was significantly downregulated in BxPC-3-LN (fold-change>10) and the expression levels of miRNA-218 were confirmed by RT-PCR. The group with lymph node metastasis and the elder group (age>64) showed lower expression of miRNA-218 (P=0.003 and 0.002), compared to patients without lymph nodes metastasis and patients in the younger group (age≤64), respectively. The expression of miRNA‑218 showed a decreasing trend from normal acinar/ductal epithelium, intraductal

  11. [Retracted] Slit-miR-218-Robo axis regulates retinal neovascularization.

    Science.gov (United States)

    Kong, Yichun; Sun, Bei; Han, Quanhong; Han, Shuang; Wang, Yuchuan; Chen, Ying

    2016-12-01

    Following the publication of this article, it was brought to our attention that five of the Figures contained in this study were published entirely, or in part, in the following publication, on which several of us were co-authors: Han S, Kong YC, Sun B, Han QH, Chen Y and Wang YC: microRNA-218 inhibits oxygen-induced retinal neovascularization via reducing the expression of roundabout 1. Chin Med J (Engl) 129: 709-715, 2016. While we had intended that these papers offered different research perspectives, we were reminded of the fact that, in submitting the article to International Journal of Molecular Medicine, the work described therein was required to be "original research that has not been published previously, and is not under consideration for publication elsewhere, in whole or in part". Therefore, owing to the redundancy in the data between these publications, the above paper is to be retracted. All the authors have agreed to the retraction. We sincerely apologize for our misunderstanding, and deeply regret any inconvenience this mistake has caused.[the original article was published in the International Journal of Molecular Medicine 37: 1139-1145, 2016; DOI: 10.3892/ijmm.2016.2511].

  12. The historical (218 ± 14 aBP) explosive eruption of Tutupaca volcano (Southern Peru)

    Science.gov (United States)

    Samaniego, Pablo; Valderrama, Patricio; Mariño, Jersy; van Wyk de Vries, Benjamín; Roche, Olivier; Manrique, Nélida; Chédeville, Corentin; Liorzou, Céline; Fidel, Lionel; Malnati, Judicaëlle

    2015-06-01

    The little known Tutupaca volcano (17° 01' S, 70° 21' W), located at the southern end of the Peruvian arc, is a dacitic dome complex that experienced a large explosive eruption during historical times. Based on historic chronicles and our radiometric data, this eruption occurred 218 ± 14 aBP, probably between 1787 and 1802 AD. This eruption was characterised by a large sector collapse that triggered a small debris avalanche (<1 km3) and an associated pyroclastic eruption whose bulk volume was 6.5-7.5 × 107 m3. Both units were emplaced synchronously and spread onto the plain situated to the northeast of Tutupaca volcano. The spatial and temporal relationship between the debris avalanche and the pyroclastic density current deposits, coupled with the petrological similarity between the juvenile fragments in the debris avalanche, the pyroclastic density current deposits and the pre-avalanche domes, indicates that juvenile magma was involved in the sector collapse. Large amounts of hydrothermally altered material are also found in the avalanche deposit. Thus, the ascent of a dacitic magma, coupled with the fact that the Tutupaca dome complex was constructed on top of an older, altered volcanic sequence, probably induced the destabilisation of the hydrothermally active edifice, producing the debris avalanche and its related pyroclastic density currents. This eruption probably represents the youngest debris avalanche in the Andes and was accompanied by one of the larger explosive events to have occurred in Southern Peru during historical times.

  13. Synthesis and biological evaluation of anti-1-amino-2-[18F]fluoro-cyclobutyl-1-carboxylic acid (anti-2-[18F]FACBC) in rat 9L gliosarcoma.

    Science.gov (United States)

    Yu, Weiping; Williams, Larry; Camp, Vernon M; Olson, Jeffrey J; Goodman, Mark M

    2010-04-01

    A new [(18)F] labeled amino acid anti-1-amino-2-[(18)F]fluoro-cyclobutyl-1-carboxylic acid 9 (anti-2-[(18)F]FACBC) was synthesized in 30% decay-corrected yield with high radiochemical purity over 99%. The cyclic sulfamidate precursor was very stable and highly reactive towards nucleophilic radiofluorination. Cell uptake assays with rat 9L gliosarcoma cells showed that [(18)F]9 was transported into tumor cells via multiple amino acid transport systems, including L and A systems. Biodistribution study in rats with intracranial 9L gliosarcoma tumors demonstrated that [(18)F]9 had a rapid and prolonged accumulation in tumors with 26:1 tumor to brain ratio at 120 min post-injection. In this model, [(18)F]9 is a potential PET tracer for brain tumor imaging.

  14. Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis.

    Science.gov (United States)

    Pruszyński, Marek; Bilewicz, Aleksander; Zalutsky, Michael R

    2008-04-01

    The goal of this study was to evaluate a new approach that can be applied for labeling biomolecules with (211)At. Many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking different (211)At labeling strategies. The approach evaluated in this study was to attach astatide anions to soft metal cations, which are also complexed by a bifunctional ligand. Ultimately, this complex could in principle be subsequently conjugated to a biomolecule with the proper selection of ligand functionality. We report here the attachment of (211)At(-) and *I(-) (*I = (131)I or (125)I) anions to the soft metal cations Rh(III) and Ir(III), which are complexed by the 1,5,9,13-tetrathiacyclohexadecane-3,11-diol (16aneS4-diol) ligand. Radioactive *I(-) anions were used for preliminary studies directed at the optimization of reaction conditions and to provide a baseline for comparison of results with (211)At. Four complexes Rh[16aneS4-diol]*I/(211)At and Ir[16aneS4-diol]*I/(211)At were synthesized in high yield in a one-step procedure, and the products were characterized mainly by paper electrophoresis and reversed-phase HPLC. The influences of time and temperature of heating and concentrations of metal cations and sulfur ligand 16aneS4-diol, as well as pH on the reaction yields were determined. Yields of about 80% were obtained when the quantities of Rh(III) or Ir(III) cations and 16aneS4-diol ligand in the solutions were 62.5 nmol and 250 nmol, respectively, and the pH ranged 3.0-4.0. Syntheses required heating for 1-1.5 h at 75-80 degrees C. The influence of microwave heating on the time and completeness of the complexation reaction was evaluated and compared with the conventional method of heating in an oil bath. Microwave synthesis accelerates reactions significantly. With microwave heating, yields of about 75% for Rh[16aneS4-diol](131)I and Ir[16aneS4-diol](131)I complexes were obtained after only 20 min exposure of the reaction mixtures to

  15. miR-218 inhibits the invasion and migration of colon cancer cells by targeting the PI3K/Akt/mTOR signaling pathway.

    Science.gov (United States)

    Zhang, Xiangliang; Shi, Huijuan; Tang, Hongsheng; Fang, Zhiyuan; Wang, Jiping; Cui, Shuzhong

    2015-05-01

    Colon cancer is one of the most common and lethal malignancies worldwide. Despite major advances in the treatment of colon cancer, the prognosis remains very poor. Thus, novel and effective therapies for colon cancer are urgently needed. In the present study, the expression status of miR-218 and the role of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway were investigated in colon cancer samples. Firstly, we observed that miR-218 expression was significantly reduced, while PI3K/Akt/mTOR pathway activity was enhanced. The overexpression of miR-218 suppressed the proliferation, migration and invasion of LoVo colon cancer cells, whereas the inhibition of miR-218 promoted these processes. Furthermore, the PI3K/Akt/mTOR signaling pathway was identified as a direct target of miR-218. The upregulation of miR-218 inhibited the activation of the PI3K/Akt/mTOR signaling pathway, as well as the expression of matrix metalloproteinase (MMP)9. The downregulation of miR-218 activated the PI3K/Akt/mTOR signaling pathway and promoted MMP9 expression. Taken together, our results demonstrate that miR-218 suppresses the proliferation, migration and invasion of LoVo colon cancer cells by targeting the PI3K/Akt/mTOR signaling pathway and MMP9. Our data indicate that miR-218 is a potential target in the treatment of colon cancer.

  16. 218 例残冠用金属烤瓷冠修复效果的临床评价%Evaluation on clinical effect of ceramic alloy crown on treating residual tooth in 218 patients

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective: To evaluate the forward clinical effect of ceramic alloy crown on treating residual tooth. Methods: After the treating residual teeth of 218 patients by ceramic alloy crown, to observed the clinical effect for two to seven years after treatment. Results: The rate of forward success was 98% in all of the 218 patients. Conclusion: It is suggest that many different factors that influence forward successful treatment to avoid failing.%目的:评价用金属烤瓷冠修复残冠的临床效果。方法:对 218 例残冠病人用金属烤瓷冠修复治疗后,经过 2~7a 的随访复查,以观察该项治疗的效果。结果:本组病例修复成功率为 98%。讨论:分析了影响修复成功的各种因素,以便进一步完善该项修复治疗。

  17. A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish.

    Science.gov (United States)

    Fish, Jason E; Wythe, Joshua D; Xiao, Tong; Bruneau, Benoit G; Stainier, Didier Y R; Srivastava, Deepak; Woo, Stephanie

    2011-04-01

    Members of the Slit family of secreted ligands interact with Roundabout (Robo) receptors to provide guidance cues for many cell types. For example, Slit/Robo signaling elicits repulsion of axons during neural development, whereas in endothelial cells this pathway inhibits or promotes angiogenesis depending on the cellular context. Here, we show that miR-218 is intronically encoded in slit2 and slit3 and that it suppresses Robo1 and Robo2 expression. Our data indicate that miR-218 and multiple Slit/Robo signaling components are required for heart tube formation in zebrafish and that this network modulates the previously unappreciated function of Vegf signaling in this process. These findings suggest a new paradigm for microRNA-based control of ligand-receptor interactions and provide evidence for a novel signaling pathway regulating vertebrate heart tube assembly.

  18. Heparin sodium compliance to USP monograph: structural elucidation of an atypical 2.18 ppm NMR signal.

    Science.gov (United States)

    Mourier, Pierre A J; Guichard, Olivier Y; Herman, Fréderic; Viskov, Christian

    2012-01-01

    The ¹H nuclear magnetic resonance (NMR) acceptance criteria in the new heparin US Pharmacopeia (USP) monograph do not take into account potential structural modifications responsible for any extra signals observed in ¹H NMR spectra, some purified heparins may be non-compliant under the proposed new USP guidelines and incorrectly classified as unsuitable for pharmaceutical use. Heparins from the "ES" source, containing an extra signal at 2.18 ppm, were depolymerized under controlled conditions using heparinases I, II, and III. The oligosaccharides responsible for the 2.18 ppm signal were enriched using orthogonal chromatographic techniques. After multiple purification steps, we obtained an oligosaccharide mixture containing a highly enriched octasaccharide bearing the structural modification responsible for the extra signal. Following heparinase I depolymerization, a pure tetrasaccharide containing the fingerprint structural modification was isolated for full structural determination. Using 1D and 2D ¹H NMR spectroscopy, the structural moiety responsible for the extra signal at 2.18 ppm was identified as an acetyl group on the heparin backbone, most likely resulting from a very minor manufacturing process side reaction that esterifies the uronic acid at position 3. Such analytical peculiarity has always been present in this heparin source and it was used safety over the years.

  19. Biological properties of 2'-[18F]fluoroflumazenil for central benzodiazepine receptor imaging.

    Science.gov (United States)

    Chang, Young Soo; Jeong, Jae Min; Yoon, Young Hyun; Kang, Won Jun; Lee, Seung Jin; Lee, Dong Soo; Chung, June-Key; Lee, Myung Chul

    2005-04-01

    A novel positron emitting agent, 2'-[18F]fluoroflumazenil (fluoroethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-benzo-[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate, FFMZ), has been reported for benzodiazepine imaging. In the present study, biological properties of [18F]FFMZ were investigated. Stability tests of [18F]FFMZ in human and rat sera were performed. Biodistribution was investigated in mice and phosphorimages of brains were obtained from rats. A receptor binding assay was performed using rat brain (mixture of cortex and cerebellum) homogenate. A static positron emission tomography (PET) image was obtained from a normal human volunteer. Although [18F]FFMZ was stable in human serum, it was rapidly hydrolyzed in rat serum. The hydrolysis was 39%, 63% and 92% at 10, 30 and 60 min, respectively. According to the biodistribution study in mice, somewhat even distribution (between 2 approximately 3% ID/g) was observed in most organs. Intestinal uptake increased up to 6% ID/g at 1 h due to biliary excretion. Bone uptake slowly increased from 1.5% to 3.5% ID/g at 1 h. High uptakes in the cortex, thalamus and cerebellum, which could be completely blocked by coinjection of cold FMZ, were observed by phosphorimaging study using rats. Determination of Kd value and Bmax using rat brain tissue was performed by Scatchard plotting and found 1.45+/-0.26 nM and 1.08+/-0.03 pmol/mg protein, respectively. The PET image of the normal human volunteer showed high uptake in the following decreasing order: frontal cortex, temporal cortex, occipital cortex, cerebellum, parietal cortex and thalamus. In conclusion, the new FMZ derivative, [18F]FFMZ appears to be a promising PET agent for central benzodiazepine receptor imaging with a convenient labeling procedure and a specific binding property.

  20. Synthesis of 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine as a radioligand for imaging nicotinic acetylcholine receptors

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Nicotinic acetylcholine receptors (nChRs) are involved in the variouspharmacological effects or disease states. In order to study the central nChRs by PETor SPECT, some radioligands have been investigated. In this paper, the procedurefor synthesis of 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine (2-[18F]-A-85380), apotential PET ligand for in vivo imaging nicotinic acetylcholine receptor was described.2-[18F]-A-85380 was prepared from the precursor, 2-nitro-3-[(1-(tert-butoxycarbonyl)-2-(S)-azetidinyl)methoxy]pyridine(4), which was synthesized with commercial (S)-2-azetid- inecarboxylic acid as starting material. The whole procedure for radiosynthesisand purification was executed in about lh and 45-55% of the added fluorine-18 wasfound in the purified 2-[18F]-A-85380, with specific activity of 1.0-2.2 × 1011 Bq/μmol.``

  1. SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung's disease.

    Science.gov (United States)

    Tang, Weibing; Tang, Junwei; He, Jun; Zhou, Zhigang; Qin, Yufeng; Qin, Jingjing; Li, Bo; Xu, Xiaoqun; Geng, Qiming; Jiang, Weiwei; Wu, Wei; Wang, Xinru; Xia, Yankai

    2015-06-01

    Hirschsprung's disease (HSCR) is a rare congenital disease caused by impaired proliferation and migration of neural crest cells. We investigated changes in expression of microRNAs (miRNAs) and the genes they regulate in tissues of patients with HSCR. Quantitative real-time PCR and immunoblot analyses were used to measure levels of miRNA, mRNAs, and proteins in colon tissues from 69 patients with HSCR and 49 individuals without HSCR (controls). Direct interactions between miRNAs and specific mRNAs were indentified in vitro, while the function role of miR-218-1 was investigated by using miR-218 transgenic mice. An increased level of miR-218-1 correlated with increased levels of SLIT2 and decreased levels of RET and PLAG1 mRNA and protein. The reductions in RET and PLAG1 by miR-218-1 reduced proliferation and migration of SH-SY5Y cells. Overexpression of the secreted form of SLIT2 inhibited cell migration via binding to its receptor ROBO1. Bowel tissues from miR-218-1 transgenic mice had nerve fibre hyperplasia and reduced numbers of gangliocytes, compared with wild-type mice. Altered miR-218-1 regulation of SLIT2, RET and PLAG1 might be involved in the pathogenesis of HSCR.

  2. The impact of pri-miR-218 rs11134527 on the risk and prognosis of patients with esophageal squamous cell carcinoma.

    Science.gov (United States)

    Jiang, Lin; Wang, Chaofu; Sun, Canlin; Xu, Yumin; Ding, Zhongqi; Zhang, Xueling; Huang, Junxing; Yu, Hong

    2014-01-01

    MicroRNA-218 (miR-218) acts as a tumor suppressor in numerous types of cancer by regulation of the expression of target genes. The aim of this study was to investigate whether polymorphisms in miR-218 LAMB3 pathway were associated with the risk and prognosis of esophageal squamous cell carcinoma (ESCC). Pri-mir-218 rs11134527 and LAMB3 rs2566 were genotyped in ESCC patients and 745 controls to assess their associations with cancer risk and overall survival. Pri-mir-218 rs11134527 was significantly associated with a decreased risk of ESCC under codominant, recessive and additive models. Although there was a significant association between rs11134527 and better survival of ESCC patients under codominant, recessive and additive models, the association disappeared after adjustment for TNM and LNM. However, further stratified analysis revealed that the association remained significant in patients with TNM stages I and II or non-LNM. Our data suggest that pri-miR-218 rs11134527 may contribute to the genetic susceptibility and prognosis for ESCC in Chinese Han population.

  3. Thermo-chemotherapy Induced miR-218 upregulation inhibits the invasion of gastric cancer via targeting Gli2 and E-cadherin.

    Science.gov (United States)

    Ruan, Qiang; Fang, Zhi-Yuan; Cui, Shu-Zhong; Zhang, Xiang-Liang; Wu, Yin-Bing; Tang, Hong-Sheng; Tu, Yi-Nuo; Ding, Yan

    2015-08-01

    Thermo-chemotherapy has been proven to reduce the invasion capability of cancer cells. However, the molecular mechanism underlying this anti-invasion effect is still unclear. In this study, the role of thermo-chemotherapy in the inhibition of tumor invasion was studied. The results demonstrated that expression of miR-218 was downregulated in gastric cancer tissues, which had a positive correlation with tumor invasion and metastasis. In vitro thermo-chemotherapy increased miR-218 expression in SGC7901 cells and inhibited both proliferation and invasion of cancer cells. Gli2 was identified as a downstream target of miR-218, and its expression was negatively regulated by miR-218. The thermo-chemotherapy induced miR-218 upregulation was also accompanied by increasing of E-cadherin expression. In conclusion, the present study indicates that thermo-chemotherapy can effectively decrease the invasion capability of cancer cells and increase cell-cell adhesion. miR-218 and its downstream target Gli2, as well as E-cadherin, participate in the anti-invasion process.

  4. 218例幼年特发性关节炎血液系统的临床表现

    Institute of Scientific and Technical Information of China (English)

    覃肇源; 徐明; 黄婷婷; 丘小汕; 陈志凤; 刘关娜

    2005-01-01

    幼年特发性关节炎(juvenile idiopathic arthritis,JLA)是儿童常见的结缔组织病之一,常合并慢性病贫血(anemia of chronic disease,ACD)或称炎症性贫血(inflamatory anemia)。1994年6月~2004年8月,我科收住了218例JIA,乃回顾分析本病在血液系统的异常临床表现及实验室检查,以加深JLA导致ACD的认识。

  5. Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes.

    Science.gov (United States)

    Kim, Mirang; Kim, Jong-Hwan; Baek, Su-Jin; Kim, Seon-Young; Kim, Yong Sung

    2016-06-01

    SLIT has been suggested as a key regulator of cancer development and a promising therapeutic target for cancer treatment. Herein, we analyzed expression and methylation of SLIT1/SLIT2/SLIT3 in 11 gastric cancer cell lines, 96 paired gastric tumors and adjacent normal gastric tissues, and 250 gastric cancers provided by The Cancer Genome Atlas. Methylation of SLIT1/SLIT2/SLIT3 was found both in early gastric cancers, and in advanced gastric cancers. Even normal gastric tissue showed increased methylation of SLIT1 and SLIT3 that correlated with patient age. Furthermore, epigenetic inactivation of SLIT occurred in a gastric cancer subtype-dependent manner. SLIT2 and SLIT3 expression was reduced in Epstein-Barr virus-positive and microsatellite instability subtypes, but increased in the genomically stable subtype. Expression of miR‑218 correlated negatively with methylation of SLIT2 or SLIT3. These findings suggest that a molecular subtype-specific therapeutic strategy is needed for targeting SLITs and miR-218 in treatment of gastric cancer.

  6. The First Circumstellar Disk Imaged in Silhouette with Adaptive Optics: MagAO Imaging of Orion 218-354

    CERN Document Server

    Follette, Katherine B; Males, Jared R; Kopon, Derek; Wu, Ya-Lin; Morzinski, Katie M; Hinz, Philip; Rodigas, Timothy J; Puglisi, Alfio; Esposito, Simone; Riccardi, Armando; Pinna, Enrico; Xompero, Marco; Briguglio, Runa

    2013-01-01

    We present high resolution adaptive optics (AO) corrected images of the silhouette disk Orion 218-354 taken with Magellan AO (MagAO) and its visible light camera, VisAO, in simultaneous differential imaging (SDI) mode at H-alpha. This is the first image of a circumstellar disk seen in silhouette with adaptive optics and is among the first visible light adaptive optics results in the literature. We derive the disk extent, geometry, intensity and extinction profiles and find, in contrast with previous work, that the disk is likely optically-thin at H-alpha. Our data provide an estimate of the column density in primitive, ISM-like grains as a function of radius in the disk. We estimate that only ~10% of the total sub-mm derived disk mass lies in primitive, unprocessed grains. We use our data, Monte Carlo radiative transfer modeling and previous results from the literature to make the first self-consistent multiwavelength model of Orion 218-354. We find that we are able to reproduce the 1-1000micron SED with a ~2...

  7. Testing results and analysis of 218 patients with Henoch Schonlein purpura in children with food intolerance%218例过敏性紫癜患儿食物不耐受检测结果及分析

    Institute of Scientific and Technical Information of China (English)

    高健

    2016-01-01

    Objective:To understand about the food allergies of children with HSP by the detection of Henoch Schonlein purpura (HSP) in children with food allergen IgG level in serum,then guiding the HSP children's diet. Method:218 cases of children with HSP were selected for food allergen specific IgG (sIgG) detection.The food allergen specific IgG antibody levels are divided into 4 levels:negative:(IgG0.10~0.20U/L,+++),severe sensitive(IgG>0.20U/L).Results:①There were 181 patients with food intolerance in the 218 cases of HSP;②Animal protein allergenicity was significantly higher than that of plant source;③The children of HSP who had food allergy were absolute fasting corresponding sensitive food in three months,then we found the level of IgG about food allergens and secondary were obviously decreased.Conclusion:Food intolerance IgG levels are higher in children with HSP.Through the detection of food allergens in children with HSP IgG level,it can guide the diet to reduce food borne allergies.%目的:通过检测过敏性紫癜(HSP)患儿血清中食物过敏原IgG(sIgG)水平,了解HSP患儿食物过敏的情况,进而指导HSP患儿的饮食及治疗。方法:选取某医院HSP患儿共218例,进行食物变应原特异性IgG(sIgG)检测,将sIgG水平分为4级:阴性:IgG<0.05U/L,+(轻度敏感):IgG0.05~0.10U/L,++(中度敏感):IgG>0.10~0.20U/L,+++(重度敏感):IgG>0.20U/L。结果:①218例中181例阳性;②动物源蛋白致敏性明显高于植物源;③要求患儿绝对禁食对应敏感食物3月后复测食物IgG水平,可发现sIgG阳性率明显降低。结论:食物不耐受IgG水平在HSP患儿中较高,同时通过检测食物sIgG水平可指导HSP患儿的饮食以达到降低食物源性过敏的目的。

  8. Asociation between hydroxylase gene A218C polymorphism and anger started as well as anger control trait%TPH基因A218C多态性与愤怒启动及控制特质的关系

    Institute of Scientific and Technical Information of China (English)

    侯俊林; 詹向红; 刘永; 闫秀娟; 闫国立; 李伟; 刘胜利; 王淑玲

    2012-01-01

    Objective: To discuss the association of tryptophan hydroxylase gene A218C polymorphism and anger started as well as anger control trait. Methods: After the subjects were selected by STAXI-2 questionnaire, blood of them was sampled, DNA was extracted by phenol-chloroform method, genotyped by PCR-LDR method, and data was statistically analyzed. Results: ①For high trait anger subjects, there was statistical significance of the scores of anger control-out( AC-O) of male in three genotype groups(P<0.05). ②For low trait anger subjects,there was statistical significance of the following scores of the subjects hi three genotype groups(P<0.05): anger control(AC), anger control-out(AC-0). anger control-in(AC-I) and anger control-out of female(AC-0). Conclusion: There was the association of TPH gene A218C polymorphism with anger control-out trait of normal male college students with high trait anger in China. The locus polymorphism was also related to the following anger traits of normal college students with low trait anger in China: anger control trait, anger control-out trait, anger control-in trait,anger control-out trait of female.%目的:探讨TPH基因A218C多态性与愤怒启动及控制特质的关系.方法:采用状态-特质愤怒表达量表2( STAXI-2)筛选被试,经采血、酚-氯仿法提取DNA、PCR-LDR法基因分型后,对数据进行统计分析.结果:①高特质怒被试3个基因型组男性控制发怒(AC-O)得分差异有统计学意义(P<0.05).②低特质怒被试3个基因型组以下得分差异有统计学意义(P<0.05):怒的控制(AC),控制发怒(AC-O),控制郁怒(AC-I),女性控制发怒(AC-O).结论:TPH基因A218C多态性与我国正常大学生中高特质怒男性的控制发怒特质有关,还与我国正常大学生中低特质怒者怒的控制特质、控制发怒特质、控制郁怒特质及低特质怒女性的控制发怒特质有关.

  9. Clinical analysis on 218 children with tic disorder and exploration on causes of misdiagnosis%218例儿童抽动障碍临床分析及误诊原因探讨

    Institute of Scientific and Technical Information of China (English)

    唐渊; 江莲英; 陈若珊; 梁创

    2010-01-01

    目的:总结儿童抽动障碍临床特点,探讨误诊原因,减少误诊误治.方法:对218例儿童抽动障碍患儿的临床资料、诊断、治疗情况进行分析.结果:218例儿童抽动障碍患儿中,男性明显多于女性,多见于学龄儿童,以短暂性抽动症为主,临床表现多样化,容易误诊.该组误诊率高达46.3%,误诊原因主要是家长不重视、医生认识不足以及该病诊断的不确定性.结论:正确认识儿童抽动障碍临床特点并准确评价病情严重程度,做到药物治疗和心理指导个体化,多数患儿经心理和药物治疗,可以治愈.该病临床误诊率很高,医师全面掌握其基本表现和临床特点,呼吁家长和学校要重视儿童的心理健康,对减少误诊甚为重要.

  10. High frequency microphone measurements for transition detection on airfoils. Risø C2-18 appendix report

    DEFF Research Database (Denmark)

    Døssing, Mads

    Time series of pressure fluctuations has been obtained using high frequency microphones distributed over the surface of airfoils undergoing wind tunnel tests in the LM Windtunnel, owned by ’LM Glasfiber’, Denmark. The present report describes the dataanalysis, with special attention given...... to transition detection. It is argued that the transition point can be detected by observing the increase in the mean of the Fourier spectre and that thismethod is very stable froma numerical point of view. Other important issues are also discussed, e.g. the variation of pressure standard deviations (sound...... pressure) and Tollmien-Schlichting frequencies. The tests were made at Reynolds and Mach numbers corresponding to the operating conditions of a typical horizontal axis wind turbine (HAWT). The Risø B1-18, Risø C2-18 and NACA0015 profiles were tested and the measured transition points are reported....

  11. Microwave Absorption Properties of Ni-Foped SiC Powders in the 2-18 GHz Frequency Range

    Science.gov (United States)

    Jin, Hai-Bo; Li, Dan; Cao, Mao-Sheng; Dou, Yan-Kun; Chen, Tao; Wen, Bo; Simeon, Agathopoulos

    2011-03-01

    Ni-doped SiC powder with improved dielectric and microwave absorption properties was prepared by self-propagating high-temperature synthesis (SHS). The XRD analysis of the as-synthesized powders suggests that Ni is accommodated in the sites of Si in the lattice of SiC, which shrinks in the presence of Ni. The experimental results show an improvement in the dielectric properties of the Ni-doped SiC powder in the frequency range of 2-18 GHz. The bandwidth of the reflection loss below -10 dB is broadened from 3.04 (for pure SiC) to 4.56 GHz (for Ni-doped SiC), as well as the maximum reflection loss of produced powders from 13.34 to 22.57 dB, indicating that Ni-doped SiC could be used as an effective microwave absorption material.

  12. Microwave Absorption Properties of Ni-Foped SiC Powders in the 2-18 GHz Frequency Range

    Institute of Scientific and Technical Information of China (English)

    JIN Hai-Bo; LI Dan; CAO Mao-Sheng; DOU Yan-Kun; CHEN Tao; WEN Bo; Simeon Agathopoulos

    2011-01-01

    Ni-doped SiC powder with improved dielectric and microwave absorption properties was prepared by selfpropagating high-temperature synthesis(SHS). The XRD analysis of the asynthesized powders suggests that Ni is accommodated in the sites of Si in the lattice of SiC, which shrinks in the presence of Ni. The experimental results show an improvement in the dielectric properties of the Ni-doped SiC powder in the frequency range of 2-18 GHz. The bandwidth of the reflection loss below-10 dB is broadened from 3.04(for pure SiC) to 4.56 GHz (for Ni-doped SiC), as well as the maximum reflection loss of produced powders from 13.34 to 22.57dB, indicating that Ni-doped SiC could be used as an effective microwave absorption material.

  13. Effect of YM218, a nonpeptide vasopressin V(1A) receptor-selective antagonist, on rat mesangial cell hyperplasia and hypertrophy.

    Science.gov (United States)

    Tahara, Atsuo; Tsukada, Junko; Tomura, Yuichi; Suzuki, Takeshi; Yatsu, Takeyuki; Shibasaki, Masayuki

    2007-06-01

    Mesangial cell growth constitutes a key feature of progressive glomerular injury. Vasopressin (AVP), a potent peptide vasoconstrictor, acts on mesangial cells through the V(1A) receptors, inducing contraction and cell proliferation. This study examined the effects of YM218, a nonpeptide AVP V(1A) receptor-selective antagonist, on the mitogenic and hypertrophic effects of AVP in rat mesangial cells. When added to mesangial cells whose growth was arrested, AVP concentration-dependently induced hyperplasia and hypertrophy. YM218 potently prevented AVP-induced hyperplasia and hypertrophy of these cells. Furthermore, AVP stimulated endothelin (ET)-1 secretion from mesangial cells in a concentration-dependent manner and this effect was potently inhibited by YM218. ET-1 also induced hyperplasia and hypertrophy in mesangial cells and this effect was completely abolished by ET(A) receptor-selective antagonist YM598. In addition, AVP-induced hyperplasia and hypertrophy were partly inhibited by YM598. These results suggest that AVP may modulate mesangial cell growth not only by its direct action but also through the stimulation of ET-1 secretion. YM218 displays high potency in inhibiting the AVP-induced physiologic responses of mesangial cells via the V(1A) receptors and is a potent pharmacologic probe for investigating the physiologic and pathophysiologic roles of AVP in several renal diseases.

  14. 31 CFR 585.218 - Trade in United Nations Protected Areas of Croatia and those areas of the Republic of Bosnia and...

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Trade in United Nations Protected... HERZEGOVINA SANCTIONS REGULATIONS Prohibitions § 585.218 Trade in United Nations Protected Areas of Croatia... importation from, exportation to, or transshipment of goods through the United Nations Protected Areas in...

  15. CRYSTAL-STRUCTURE OF DEOXYGENATED LIMULUS-POLYPHEMUS SUBUNIT-II HEMOCYANIN AT 2.18-ANGSTROM RESOLUTION - CLUES FOR A MECHANISM FOR ALLOSTERIC REGULATION

    NARCIS (Netherlands)

    HAZES, B; MAGNUS, KA; BONAVENTURA, C; BONAVENTURA, J; DAUTER, Z; KALK, KH; HOL, WGJ

    1993-01-01

    The crystal structure of Limulus polyphemus subunit type II hemocyanin in the deoxygenated state has been determined to a resolution of 2.18 angstrom. Phase information for this first structure of a cheliceratan hemocyanin was obtained by molecular replacement using the crustacean hemocyanin structu

  16. Whole-Genome Sequences of the Archetypal K1 Escherichia coli Neonatal Isolate RS218 and Contemporary Neonatal Bacteremia Clinical Isolates SCB11, SCB12, and SCB15.

    Science.gov (United States)

    Day, Michael W; Jackson, Lydgia A; Akins, Darrin R; Dyer, David W; Chavez-Bueno, Susana

    2015-02-26

    Neonatal bacteremia Escherichia coli strains commonly belong to the K1 capsular type. Their ability to cause invasive neonatal disease appears to be determined by other virulence factors that have yet to be identified. We report here the genome sequences of four E. coli neonatal bacteremia isolates, including that of the archetypal strain RS218.

  17. Association between A218C polymorphism of the tryptophan-hydroxylase-1 gene, harm avoidance and binge eating behavior in bulimia nervosa.

    Science.gov (United States)

    Monteleone, Palmiero; Tortorella, Alfonso; Martiadis, Vassilis; Serino, Ismene; Di Filippo, Carmela; Maj, Mario

    2007-06-21

    Genes involved in serotonin transmission are likely involved in the biological predisposition to bulimia nervosa. We investigated whether the A218C polymorphism of the tryptophan-hydroxylase-1 gene was associated to bulimia nervosa and/or to some phenotypic aspects of the disorder. One hundred eighty Caucasian women (91 patients with bulimia nervosa and 89 healthy controls) were enrolled into the study. They underwent a blood sample collection for A218C polymorphism of the tryptophan-hydroxylase-1 genotyping and a clinical evaluation assessing comorbidity for Axis I and II psychiatric disorders, harm avoidance personality dimension and bulimic symptoms. The distribution of both tryptophan-hydroxylase-1 A218C genotypes and alleles did not significantly differ between patients and controls. Bulimic women with the AA genotype exhibited a more severe binge eating behavior and higher harm avoidance scores than those with CC genotype. These findings support the idea that tryptophan-hydroxylase-1 A218C polymorphism does not play a part in the genetic susceptibility to bulimia nervosa, but it seems to be involved in predisposing bulimic patients to a more disturbed eating behavior and higher harm avoidance.

  18. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 218, Revision 1 (FGE.218Rev1): alpha,beta-Unsaturated aldehydes and precursors from subgroup 4.2 of FGE.19: Furfural derivatives

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister;

    .001], for which there was a request for genotoxicity data in FGE.218. Flavouring Group Evaluation 218 (FGE.218) consists of furfural [FL-no: 13.018] and seven substances structurally related to furfural, 5-methylfurfural [FL-no: 13.001], furfuryl alcohol [FL-no: 13.019] and five esters of furfuryl alcohol...... is expected to be oxidised to the alpha,beta-unsaturated aldehyde furfural. However, based on the data then available the Panel concluded that furfural is not of concern with respect to genotoxicity. Furthermore, the Panel concluded that not only furfural but also the structurally related furfuryl alcohol...... to 5-[(sulphoxy)methyl]furfural which shows genotoxic potential in vitro, 5-hydroxymethylfurfural could not be evaluated through the Procedure. Accordingly, the Panel concluded that 5-methylfurfural could not be evaluated through the Procedure either. Industry has submitted additional data on the 5...

  19. 2-deoxy-2-(18F)fluoro-D-glucose positron emission tomography/computed tomography imaging in paediatric oncology

    Institute of Scientific and Technical Information of China (English)

    John; Freebody; Eva; A; Wegner; Monica; A; Rossleigh

    2014-01-01

    Positron emission tomography(PET) is a minimally in-vasive technique which has been well validated for the diagnosis, staging, monitoring of response to therapy, and disease surveillance of adult oncology patients. Tra-ditionally the value of PET and PET/computed tomogra-phy(CT) hybrid imaging has been less clearly defined for paediatric oncology. However recent evidence has emerged regarding the diagnostic utility of these mo-dalities, and they are becoming increasingly important tools in the evaluation and monitoring of children with known or suspected malignant disease. Important indi-cations for 2-deoxy-2-(18F)fluoro-D-glucose(FDG) PET in paediatric oncology include lymphoma, brain tumours, sarcoma, neuroblastoma, Langerhans cell histiocytosis, urogenital tumours and neurofibromatosis type Ⅰ. This article aims to review current evidence for the use of FDG PET and PET/CT in these indications. Attention will also be given to technical and logistical issues, the description of common imaging pitfalls, and dosimetric concerns as they relate to paediatric oncology.

  20. A Tape Method for Fast Characterization and Identification of Active Pharmaceutical Ingredients in the 2-18 THz Spectral Range

    Science.gov (United States)

    Kissi, Eric Ofosu; Bawuah, Prince; Silfsten, Pertti; Peiponen, Kai-Erik

    2015-03-01

    In order to find counterfeit drugs quickly and reliably, we have developed `tape method' a transmission spectroscopic terahertz (THz) measurement technique and compared it with a standard attenuated total reflection (ATR) THz spectroscopic measurement. We used well-known training samples, which include commercial paracetamol and aspirin tablets to check the validity of these two measurement techniques. In this study, the spectral features of some active pharmaceutical ingredients (APIs), such as aspirin and paracetamol are characterized for identification purpose. This work covers a wide THz spectral range namely, 2-18 THz. This proposed simple but novel technique, the tape method, was used for characterizing API and identifying their presence in their dosage forms. By comparing the spectra of the APIs to their dosage forms (powder samples), all distinct fingerprints present in the APIs are also present in their respective dosage forms. The positions of the spectral features obtained with the ATR techniques were akin to that obtained from the tape method. The ATR and the tape method therefore, complement each other. The presence of distinct fingerprints in this spectral range has highlighted the possibility of developing fast THz sensors for the screening of pharmaceuticals. It is worth noting that, the ATR method is applicable to flat faced tablets whereas the tape method is suitable for powders in general (e.g. curved surface tablets that require milling before measurement). Finally, we have demonstrated that ATR techniques can be used to screen counterfeit antimalarial tablets.

  1. 218例40岁以下青年人肺癌临床特征分析%Clinico-pothologic studies on 218 lung cancer patients under 40 years of age

    Institute of Scientific and Technical Information of China (English)

    张颖秋; 蒋鑫; 林建武; 林莉; 庞帅; 王桂芳

    2011-01-01

    Objective To study whether the clinico-pothologic characteristics of young lung cancer patients (≤40 years of age) and compare with those of older lung cancer patients (>40 years of age).Methods Retrospective analysis was carried out to compare the clinico-pathologic features of 218 young patients (young group) with those of 944 older ones (older group). Results Compared with the older group,young group had more female (39% vs 27%, P <0. 001), different constitution of pathological types ( P < 0. 001 ) characterized with more adenocarcinoma (50.9%), more advanced-stage disease (76.0% vs 48.0%, P <0. 001) and less patients underwent surgery ( P <0. 001). Cough was the most common presentation (73.9%),and other symptoms were not common. Combined-modality therapy was not common (20.2%) in the young group. Conclusions Young patients with lung cancer present difference in clinico-pathologic features from the older ones. The younger type of lung cancer should be paid attention to.%目的 探讨≤40岁青年人肺癌的临床及病理特征,并与>40岁的中老年人肺癌进行比较。方法 对218例青年人肺癌(青年组)以及同期的944例中老年人肺癌(中老年组)进行回顾性分析,比较两组临床及病理特征。结果 青年组女性患者比例高(39% vs 27%,P<0.001),以腺癌为主要病理类型(50.9%),病理类型构成与中老年组相比有显著差异(P<0.001)。咳嗽是最常见的症状(73.9%),其他症状的发生率均不高。青年组患者确诊时晚期比例高(76.0% vs 48.0%,P<0.001),接受手术治疗比例显著低于中老年组( P<0.001),接受综合治疗比例也较低(20.2%)。结论 青年人肺癌具有其特殊的临床及病理特征,明显不同于中老年人肺癌,应提高对青年人肺癌的认识。

  2. Fiber Diffraction of the Prion-Forming Domain HET-s(218-289) Shows Dehydration-Induced Deformation of a Complex Amyloid Structure

    Energy Technology Data Exchange (ETDEWEB)

    Wan, William; Stubbs, Gerald [Vanderbilt

    2014-05-01

    Amyloids are filamentous protein aggregates that can be formed by many different proteins and are associated with both disease and biological functions. The pathogenicities or biological functions of amyloids are determined by their particular molecular structures, making accurate structural models a requirement for understanding their biological effects. One potential factor that can affect amyloid structures is hydration. Previous studies of simple stacked β-sheet amyloids have suggested that dehydration does not impact structure, but other studies indicated dehydration-related structural changes of a putative water-filled nanotube. Our results show that dehydration significantly affects the molecular structure of the fungal prion-forming domain HET-s(218–289), which forms a β-solenoid with no internal solvent-accessible regions. The dehydration-related structural deformation of HET-s(218–289) indicates that water can play a significant role in complex amyloid structures, even when no obvious water-accessible cavities are present.

  3. First observation of the beta decay of neutron-rich $^{218}Bi$ by the pulsed-release technique and resonant laser ionization

    CERN Document Server

    De Witte, H; Borzov, I N; Caurier, E; Cederkäll, J; De Smet, A; Eckhaudt, S; Fedorov, D V; Fedosseev, V; Franchoo, S; Górska, M; Grawe, H; Huber, G; Huyse, M; Janas, Z; Köster, U; Kurcewicz, W; Kurpeta, J; Plochocki, A; Van Duppen, P; Van de Vel, K; Weissman, L

    2004-01-01

    The neutron-rich isotope /sup 218/Bi has been produced in proton- induced spallation of a uranium carbide target at the ISOLDE facility at CERN, extracted from the ion source by the pulsed-release technique and resonant laser ionization, and its beta decay is studied for the first time. A half-life of 33(1)s was measured and is discussed in the self-consistent continuum-quasi particle-random- phase approximation framework that includes Gamow-Teller and first- forbidden transitions. A level scheme was constructed for /sup 218 /Po, and a deexcitation pattern of stretched E2 transitions 8/sup +/ to 6/sup +/ to 4/sup +/ to 2/sup +/ to 0/sup +/ to the ground state is suggested. Shell-model calculations based on the Kuo-Herling interaction reproduce the experimental results satisfactorily. (28 refs).

  4. Factors associated with upper respiratory tract disease caused by feline herpesvirus, feline calicivirus, Chlamydophila felis and Bordetella bronchiseptica in cats: experience from 218 European catteries

    OpenAIRE

    Helps, C. R.; Lait, P.; Damhuis, A.; Björnehammar, U.; Bolta, D.; Brovida, C.; Chabanne, L.; Egberink, H; Ferrand, G.; Fontbonne, A.; Pennisi, M G; Gruffydd-Jones, T.; Gunn-Moore, D.; Hartmann, K.; Lutz, H

    2005-01-01

    A full history of the management practices and the prevalence of upper respiratory tract disease (URTD) at 218 rescue shelters, breeding establishments and private households with five or more cats was recorded. Oropharyngeal and conjunctival swabs and blood samples were taken from 1748 cats. The prevalences of feline herpesvirus (FHV), feline calicivirus (FCV), Chlamydophila felis and Bordetella bronchiseptica were determined by PCR on swab samples. An ELISA was applied to determine the prev...

  5. Microwave-assisted synthesis of 3,1,2- and 2,1,8-Re(I) and 99mTc(I)-metallocarborane complexes.

    Science.gov (United States)

    Green, Andrew E C; Causey, Patrick W; Louie, Anika S; Armstrong, Andrea F; Harrington, Laura E; Valliant, John F

    2006-07-24

    Microwave heating was used to prepare eta5-rhenium carborane complexes in aqueous reaction media. For carboranes bearing sterically demanding substituents, isomerization of the cage from 3,1,2 to 2,1,8 derivatives occurred concomitantly with complexation. Microwave heating was equally effective at the tracer level using technetium-99m, affording access to a new class of synthons for designing novel molecular imaging agents.

  6. Heterogeneous Seeding of a Prion Structure by a Generic Amyloid Form of the Fungal Prion-forming Domain HET-s(218-289)

    Energy Technology Data Exchange (ETDEWEB)

    Wan, William; Bian, Wen; McDonald, Michele; Kijac, Aleksandra; Wemmer, David E.; Stubbs, Gerald [UCB; (Vanderbilt); (LBNL)

    2013-11-13

    The fungal prion-forming domain HET-s(218–289) forms infectious amyloid fibrils at physiological pH that were shown by solid-state NMR to be assemblies of a two-rung β-solenoid structure. Under acidic conditions, HET-s(218–289) has been shown to form amyloid fibrils that have very low infectivity in vivo, but structural information about these fibrils has been very limited. We show by x-ray fiber diffraction that the HET-s(218–289) fibrils formed under acidic conditions have a stacked β-sheet architecture commonly found in short amyloidogenic peptides and denatured protein aggregates. At physiological pH, stacked β-sheet fibrils nucleate the formation of the infectious β-solenoid prions in a process of heterogeneous seeding, but do so with kinetic profiles distinct from those of spontaneous or homogeneous (seeded with infectious β-solenoid fibrils) fibrillization. Several serial passages of stacked β-sheet-seeded solutions lead to fibrillization kinetics similar to homogeneously seeded solutions. Our results directly show that structural mutation can occur between substantially different amyloid architectures, lending credence to the suggestion that the processes of strain adaptation and crossing species barriers are facilitated by structural mutation.

  7. Retraction Statement: 'MicroRNA-218 increases cellular sensitivity to Rapamycin via targeting Rictor in cervical cancer' by Li J, Wang J, Wang Y, Qiu H.

    Science.gov (United States)

    2017-02-01

    The above article from APMIS, published online on 24 April 2015 in Wiley Online Library (wileyonlinelibrary.com) and in Volume 123, pp. 562-570, has been retracted by agreement between the authors, the journal Editors in Chief, Professors Bodil Norrild, Ben Vainer and Elisabeth Ralfkiaer, and John Wiley & Sons Ltd. The article has been retracted due to errors in the reported results. In this study, the authors used HeLa and SiHa cell lines to investigate the biological roles of miR-218. However, subsequently it emerged that the two cell lines were contaminated in the laboratory by other unknown cell lines. When repeating the experiments, it was found that the functions of miR-218 were not as significant as had been previously reported, especially its effects on rapamycin sensitivity. Reference Li J, Li X, Wang J, Wang Y, Qiu H. MicroRNA-218 increases cellular sensitivity to Rapamycin via targeting Rictor in cervical cancer. APMIS 2015; 123:562-570. doi: 10.1111/apm.12387.

  8. Contribution of plated-out 218Po and 214Po to measurements of airborne 222Rn and daughters with plastic (CR-39) nuclear track detectors

    Science.gov (United States)

    Kahn, Bernd; Wang, Zuoyuan; Sensistaffar, Edwin

    1984-01-01

    The fraction of alpha-particle tracks due to radioactivity plated out on its surface was measured for CR-39 nuclear track detector foils used to determine working level values in air. Bare foils were exposed to known concentrations of airborne 222Rn and its short-lived daughters in a calibration chamber. The amounts of 218Po and 214Po on the foil surface were measured with a calibrated diffused junction detector-spectrometer system immediately after the foils were removed from the chamber. Deposition was mostly by 218Po, with some 214Pb but essentially no 214Bi. The track density due to the plated-out radionuclides and the 222Rn, 218Po, and 214Po in chamber air was calculated and compared to the value measured by electrochemical etching. The calculated values generally were slightly above the measured values. On the basis of these calculations, the deposited radioactivity contributed slightly less than one-half of the total tracks in one test and slightly more than two-thirds in another. This effect complicates calibration of the detector relative to airborne radon daughters.

  9. 2'[(18)F]-fluoroethylrhodamine B is a promising radiotracer to measure P-glycoprotein function.

    Science.gov (United States)

    Trencsényi, György; Kertész, István; Krasznai, Zoárd T; Máté, Gábor; Szalóki, Gábor; Szabó Judit, P; Kárpáti, Levente; Krasznai, Zoltán; Márián, Teréz; Goda, Katalin

    2015-07-10

    In vivo detection of the emergence of P-glycoprotein (Pgp) mediated multidrug resistance in tumors could be beneficial for patients treated with anticancer drugs. PET technique in combination with appropriate radiotracers could be the most convenient method for detection of Pgp function. Rhodamine derivatives are validated fluorescent probes for measurement of mitochondrial membrane potential and also Pgp function. The aim of this study was to investigate whether 2'[(18)F]-fluoroethylrhodamine B ((18)FRB) a halogenated rhodamine derivative previously synthesized for PET assessment of myocardial perfusion preserved its Pgp substrate character. ATPase assay as well as accumulation experiments carried out using Pgp(+) and Pgp(-) human gynecologic (A2780/A2780(AD) and KB-3-1/KB-V1) and a mouse fibroblast cell pairs (NIH 3T3 and NIH 3T3 MDR1) were applied to study the interaction of (18)FRB with Pgp. ATPase assay proved that (18)FRB is a high affinity substrate of Pgp. Pgp(-) cells accumulated the (18)FRB rapidly in accordance with its lipophilic character. Dissipation of the mitochondrial proton gradient by a proton ionophore CCCP decreased the accumulation of rhodamine 123 (R123) and (18)FRB into Pgp(-) cells. Pgp(+) cells exhibited very low R123 and (18)FRB accumulation (around 1-8% of the Pgp(-) cell lines) which was not sensitive to the mitochondrial proton gradient; rather it was increased by the Pgp inhibitor cyclosporine A (CsA). Based on the above data we conclude that (18)FRB is a high affinity Pgp substrate and consequently a potential PET tracer to detect multidrug resistant tumors as well as the function of physiological barriers expressing Pgp.

  10. 非小细胞肺癌血浆miR-223、miR-93和miR-218的表达及其临床意义%Expression and clinical value analysis of plasma miR-223, miR-93 and miR-218 in non-small lung cancer

    Institute of Scientific and Technical Information of China (English)

    蔡静清; 王宁; 张敏

    2014-01-01

    Objective To explore the levels of plasma miR⁃223, miR⁃93 and miR⁃218 in non⁃small lung cancer( NSCLC) and analysis the relationship between the 3 indicators and clinicopathological parameters of NSCLC. Methods Plasma samples from 85 NSCLC patients before treatment were collected as NSCLC group. The real⁃time quantitative RT⁃PCR( qRT⁃PCR) was used to detect the levels of miR⁃223, miR⁃93 and miR⁃218 and the clinicopathological parameters of NSCLC patients were collected. The clinicopatho⁃logical parameters of patients with different levels of miR⁃223, miR⁃93 and miR⁃218 were compared. The receiver operating characteris⁃tic curve( ROC) was employed to analysis the clinical value of plasma miR⁃223, miR⁃93 and miR⁃218 in the diagnosis of NSCLC. Meanwhile, the plasma samples from 90 healthy volunteers at the same time were selected as control( control group) . Results There were higher levels of miR⁃223 and miR⁃93 but lower miR⁃218 in NSCLC group compaired with control group with significant difference ( P<0�05) . The level of miR⁃223 was related with TNM stage and tumor size, and miR⁃93 was related with histological type and lymph node metastasis, and miR⁃218 was related with tumor size and degree of differentiation, showing with significant difference ( P all<0�05) . The plasma level of miR⁃223 was positively correlated with miR⁃93( r=0�411) , but miR⁃223 and miR⁃93 were negatively cor⁃related with miR⁃218(r=-0�361 and r=-0�451)with statistically significance(P<0�05). The AUC, sensitivity and specificity of plasma miR⁃223, miR⁃93 and miR⁃218 in the diagnosis of NSCLC were 0�926, 95�2% and 87�1%, 0�912, 88�4% and 92�5%, and 0�941, 92�7% and 84�4%, higher than 0�774, 75�1% and 66�2% of carcinoembryonic antigen( CEA) . The combined efficiency of miR⁃223, miR⁃93 and miR⁃218 in NSCLC was superior to that alone. Conclusion There are higher expression of miR⁃223 and

  11. Area 3 Support Buildings (A3SB) H5-0992, H5-0996 PRL 218 Confirmatory Sampling Report

    Science.gov (United States)

    Mrdjenovich, Timothy

    2015-01-01

    The Area 3 Support Buildings site (A3SB) consists of two separate areas located on the north side of Beach Road in the northern portion of Kennedy Space Center, Florida (KSC), outside the secured perimeter of KSC. The A3SB areas are approximately 0.6 miles apart, and were developed as Shiffler's Grocery Store and Service Station (west site) and as a residence (east site) prior to acquisition by the National Aeronautics and Space Administration (NASA) in 1963. Both areas were used by the Bendix Company in support of NASA as chemical laboratories from 1963 through 1969. Both of the buildings were demolished by 1987. The west portion of the site was used by the US Fish & Wildlife Service (F&W) in support of the Merritt Island National Wildlife Refuge (MINWR) for parking at the entrance to the Hammock Trails from 1969 to the present. The east portion of the site was used for intermittent suspect materials staging in the early 1990s and is still used as an apiary location, but is otherwise no longer active. In support of the NASA HSWA permit requirements, this site was identified as Potential Release Location (PRL) 218 and a Solid Waste Management Unit (SWMU) Assessment (SA) was conducted in 2013. Confirmatory Sampling (CS) was recommended and approved by the KSC Remediation Team (KSCRT). Three locations of concern (LOCs) were identified and sampled at the site. The LOCs include two former chemical labs and a former suspect staging area. The CS was conducted in March of 2015 at three locations by means of Direct Push Technology (DPT) groundwater sampling and at one location for soil sampling. The samples were collected and analyzed in accordance with the approved CS Work Plan. There were no exceedances of criteria detected in any of the samples from the three LOCs. The results of this investigation indicate that past and/or present operations have not negatively impacted environmental media at the A3SB. Based upon no confirmed groundwater detections above GCTLs and no

  12. Estimation of the release and migration of lead through soils and groundwater at the Hanford Site 218-E-12B Burial Ground

    Energy Technology Data Exchange (ETDEWEB)

    Rhoads, K.; Bjornstad, B.N.; Lewis, R.E.; Teel, S.S.; Cantrell, K.J.; Serne, R.J.; Smoot, J.L.; Kincaid, C.T.; Wurstner, S.K.

    1992-10-01

    This report describes the technical basis for a groundwater transport analysis that was conducted to evaluate migration of potentially hazardous materials from the Hanford Site 218-E-12B burial ground. The analysis characterized the geologic, chemical, and hydrologic properties of the disposal site, and used that information to perform a screening analysis for transport of materials from the burial ground to downgradient groundwater locations and to the Columbia River. Subsequent sections of the appendix describe the geologic setting, geochemistry, and hydrology of the disposal site and their relationship to the transport analysis.

  13. Estimation of the release and migration of lead through soils and groundwater at the Hanford Site 218-E-12B Burial Ground. Volume 2, Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Rhoads, K.; Bjornstad, B.N.; Lewis, R.E.; Teel, S.S.; Cantrell, K.J.; Serne, R.J.; Smoot, J.L.; Kincaid, C.T.; Wurstner, S.K.

    1992-10-01

    This report describes the technical basis for a groundwater transport analysis that was conducted to evaluate migration of potentially hazardous materials from the Hanford Site 218-E-12B burial ground. The analysis characterized the geologic, chemical, and hydrologic properties of the disposal site, and used that information to perform a screening analysis for transport of materials from the burial ground to downgradient groundwater locations and to the Columbia River. Subsequent sections of the appendix describe the geologic setting, geochemistry, and hydrology of the disposal site and their relationship to the transport analysis.

  14. THE FIRST CIRCUMSTELLAR DISK IMAGED IN SILHOUETTE AT VISIBLE WAVELENGTHS WITH ADAPTIVE OPTICS: MagAO IMAGING OF ORION 218-354

    Energy Technology Data Exchange (ETDEWEB)

    Follette, Katherine B.; Close, Laird M.; Males, Jared R.; Wu, Ya-Lin; Morzinski, Katie M.; Hinz, Philip; Rodigas, Timothy J. [Steward Observatory, The University of Arizona, 933 N Cherry Avenue, Tucson, AZ 85721 (United States); Kopon, Derek [Max Planck Institute for Astronomy, Königstuhl 17, D-69117 Heidelberg (Germany); Puglisi, Alfio; Esposito, Simone; Riccardi, Armando; Pinna, Enrico; Xompero, Marco; Briguglio, Runa [INAF - Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy)

    2013-09-20

    We present high-resolution adaptive optics (AO) corrected images of the silhouette disk Orion 218-354 taken with Magellan AO (MagAO) and its visible light camera, VisAO, in simultaneous differential imaging mode at Hα. This is the first image of a circumstellar disk seen in silhouette with AO and is among the first visible light AO results in the literature. We derive the disk extent, geometry, intensity, and extinction profiles and find, in contrast with previous work, that the disk is likely optically thin at Hα. Our data provide an estimate of the column density in primitive, ISM-like grains as a function of radius in the disk. We estimate that only ∼10% of the total submillimeter derived disk mass lies in primitive, unprocessed grains. We use our data, Monte Carlo radiative transfer modeling, and previous results from the literature to make the first self-consistent multiwavelength model of Orion 218-354. We find that we are able to reproduce the 1-1000 μm spectral energy distribution with a ∼2-540 AU disk of the size, geometry, small versus large grain proportion, and radial mass profile indicated by our data. This inner radius is a factor of ∼15 larger than the sublimation radius of the disk, suggesting that it is likely cleared in the very interior.

  15. Interactions of Neuropathogenic Escherichia coli K1 (RS218 and Its Derivatives Lacking Genomic Islands with Phagocytic Acanthamoeba castellanii and Nonphagocytic Brain Endothelial Cells

    Directory of Open Access Journals (Sweden)

    Farzana Abubakar Yousuf

    2014-01-01

    Full Text Available Here we determined the role of various genomic islands in E. coli K1 interactions with phagocytic A. castellanii and nonphagocytic brain microvascular endothelial cells. The findings revealed that the genomic islands deletion mutants of RS218 related to toxins (peptide toxin, α-hemolysin, adhesins (P fimbriae, F17-like fimbriae, nonfimbrial adhesins, Hek, and hemagglutinin, protein secretion system (T1SS for hemolysin, invasins (IbeA, CNF1, metabolism (D-serine catabolism, dihydroxyacetone, glycerol, and glyoxylate metabolism showed reduced interactions with both A. castellanii and brain microvascular endothelial cells. Interestingly, the deletion of RS218-derived genomic island 21 containing adhesins (P fimbriae, F17-like fimbriae, nonfimbrial adhesins, Hek, and hemagglutinin, protein secretion system (T1SS for hemolysin, invasins (CNF1, metabolism (D-serine catabolism abolished E. coli K1-mediated HBMEC cytotoxicity in a CNF1-independent manner. Therefore, the characterization of these genomic islands should reveal mechanisms of evolutionary gain for E. coli K1 pathogenicity.

  16. An Ammonia Spectral Map of the L1495-B218 Filaments in the Taurus Molecular Cloud : I. Physical Properties of Filaments and Dense cores

    CERN Document Server

    Seo, Young Min; Goldsmith, Paul; Ward-Thompson, Derek; Kirk, Jason M; Schmalzl, Markus; Lee, Jeong-Eun; Friesen, Rachel; Langston, Glen; Masters, Joe; Garwood, Robert W

    2015-01-01

    We present deep NH$_3$ observations of the L1495-B218 filaments in the Taurus molecular cloud covering over a 3 degree angular range using the K-band focal plane array on the 100m Green Bank Telescope. The L1495-B218 filaments form an interconnected, nearby, large complex extending over 8 pc. We observed NH$_3$ (1,1) and (2,2) with a spectral resolution of 0.038 km/s and a spatial resolution of 31$"$. Most of the ammonia peaks coincide with intensity peaks in dust continuum maps at 350 $\\mu$m and 500 $\\mu$m. We deduced physical properties by fitting a model to the observed spectra. We find gas kinetic temperatures of 8 $-$ 15 K, velocity dispersions of 0.05 $-$ 0.25 km/s, and NH$_3$ column densities of 5$\\times$10$^{12}$ $-$ 1$\\times$10$^{14}$ cm$^{-2}$. The CSAR algorithm, which is a hybrid of seeded-watershed and binary dendrogram algorithms, identifies a total of 55 NH$_3$ structures including 39 leaves and 16 branches. The masses of the NH$_3$ sources range from 0.05 M$_\\odot$ to 9.5 M$_\\odot$. The masses...

  17. ExoMol molecular line lists XIX: high-accuracy computed hot line lists for H218O and H217O

    Science.gov (United States)

    Polyansky, Oleg L.; Kyuberis, Aleksandra A.; Lodi, Lorenzo; Tennyson, Jonathan; Yurchenko, Sergei N.; Ovsyannikov, Roman I.; Zobov, Nikolai F.

    2017-04-01

    Hot line lists for two isotopologues of water, H218O and H217O, are presented. The calculations employ newly constructed potential energy surfaces (PES), which take advantage of a novel method for using the large set of experimental energy levels for H216O to give high-quality predictions for H218O and H217O. This procedure greatly extends the energy range for which a PES can be accurately determined, allowing an accurate prediction of higher lying energy levels than are currently known from direct laboratory measurements. This PES is combined with a high-accuracy, ab initio dipole moment surface of water in the computation of all energy levels, transition frequencies and associated Einstein A coefficients for states with rotational excitation up to J = 50 and energies up to 30 000 cm-1. The resulting HotWat78 line lists complement the well-used BT2 H216O line list. Full line lists are made available online as Supporting Information and at www.exomol.com.

  18. The usefulness of dynamic O-(2-18F-fluoroethyl)-L-tyrosine PET in the clinical evaluation of brain tumors in children and adolescents

    DEFF Research Database (Denmark)

    Dunkl, Veronika; Cleff, Corvin; Stoffels, Gabriele;

    2015-01-01

    UNLABELLED: Experience regarding O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET in children and adolescents with brain tumors is limited. METHODS: Sixty-nine (18)F-FET PET scans of 48 children and adolescents (median age, 13 y; range, 1-18 y) were analyzed retrospectively. Twenty-six scans...... after injection, and time-activity curves of (18)F-FET uptake were assigned to 3 different patterns: constant increase; peak at greater than 20-40 min after injection, followed by a plateau; and early peak (≤ 20 min), followed by a constant descent. The diagnostic accuracy of (18)F-FET PET was assessed...... predictive value, 90%; P = 0.02). During chemotherapy, a decrease of TBRs was associated with a stable clinical course, and in 2 patients PET detected residual tumor after presumably complete tumor resection. CONCLUSION: Our findings suggest that (18)F-FET PET can add valuable information for clinical...

  19. The Atacama Cosmology Telescope: A Measurement of the Cosmic Microwave Background Power Spectrum at 148 and 218 GHz from the 2008 Southern Survey

    CERN Document Server

    Das, Sudeep; Ade, Peter A R; Aguirre, Paula; Amir, Mandana; Appel, John W; Barrientos, L Felipe; Battistelli, Elia S; Bond, J Richard; Brown, Ben; Burger, Bryce; Chervenak, Jay; Devlin, Mark J; Dicker, Simon R; Doriese, W Bertrand; Dunkley, Joanna; Dünner, Rolando; Essinger-Hileman, Thomas; Fisher, Ryan P; Fowler, Joseph W; Hajian, Amir; Halpern, Mark; Hasselfield, Matthew; Hernández-Monteagudo, Carlos; Hilton, Gene C; Hilton, Matt; Hincks, Adam D; Hlozek, Renée; Huffenberger, Kevin M; Hughes, David H; Hughes, John P; Infante, Leopoldo; Irwin, Kent D; Juin, Jean Baptiste; Kaul, Madhuri; Klein, Jeff; Kosowsky, Arthur; Lau, Judy M; Limon, Michele; Lin, Yen-Ting; Lupton, Robert H; Marsden, Danica; Martocci, Krista; Mauskopf, Phil; Menanteau, Felipe; Moodley, Kavilan; Moseley, Harvey; Netterfield, Calvin B; Niemack, Michael D; Nolta, Michael R; Page, Lyman A; Parker, Lucas; Partridge, Bruce; Reid, Beth; Sehgal, Neelima; Sherwin, Blake D; Sievers, Jon; Spergel, David N; Staggs, Suzanne T; Swetz, Daniel S; Switzer, Eric R; Thornton, Robert; Trac, Hy; Tucker, Carole; Warne, Ryan; Wollack, Ed; Zhao, Yue

    2010-01-01

    We present measurements of the cosmic microwave background (CMB) power spectrum made by the Atacama Cosmology Telescope at 148 GHz and 218 GHz, as well as the cross-frequency spectrum between the two channels. Our results clearly show the second through the seventh acoustic peaks in the CMB power spectrum. The measurements of these higher-order peaks provide an additional test of the {\\Lambda}CDM cosmological model. At l > 3000, we detect power in excess of the primary anisotropy spectrum of the CMB. At lower multipoles 500 < l < 3000, we find evidence for gravitational lensing of the CMB in the power spectrum at the 2.8{\\sigma} level. We also detect a low level of Galactic dust in our maps, which demonstrates that we can recover known faint, diffuse signals.

  20. 2-[18F]fluoro-2-deoxyglucose positron-emission tomography in staging, response evaluation, and treatment planning of lymphomas

    DEFF Research Database (Denmark)

    Specht, Lena

    2007-01-01

    2-[18F]fluoro-2-deoxyglucose positron-emission tomography (FDG-PET) is used increasingly in the clinical management of lymphomas. With regard to staging, FDG-PET is more sensitive and specific than conventional staging methods in FDG avid lymphomas (ie, Hodgkin lymphoma and most aggressive non-Hodgkin...... with the planning computed tomography (CT) scan is used increasingly. The availability of PET/CT scanners suited for virtual simulation has aided this process. However, clinical data evaluating this technique are at present sparse....... lymphomas). Despite methodological problems, in particular the lack of a valid reference test, FDG-PET is approved and generally used for this purpose. With regard to response evaluation, FDG-PET at the end of treatment seems to aid considerably in differentiating between residual masses with or without...

  1. Continuous monitoring α-activity on aerosol filters by the pseudo-coincidence-technique. Explicitly taking into account the short lived Po-218 activity; Kontinuierliche Ueberwachung der α-Aktivitaet eines Aerosolfilters mit der Pseudokoinzidenzmesstechnik. Explizite Beruecksichtigung der kurzlebigen Po-218 Aktivitaetsbeitraaege

    Energy Technology Data Exchange (ETDEWEB)

    Kraut, W.; Schwarz, W. [Duale Hochschule Baden-Wuerttemberg (DHBW), Karlsruhe (Germany). Studiengang Sicherheitswesen; Kraut, B. [Berthold Technologies GmbH und Co.KG, Bad Wildbad (Germany)

    2015-07-01

    Pseudo-coincidence-technique is applied to continuous monitoring of α-activity on aerosolfilters by proportional counters. Filter activity can markedly increase or decrease by changing air conditions especially by the amount of short lived Po-218 activity. Conditions of constant proportions of activity concentrations for the short lived species for operating this technique are seldom fulfilled. The dynamic behavior of artificial (long lived) and natural (short lived) activity is mathematically modelled and the measured moving count rates are analyzed under this model by a multivariate regression analysis for activity concentrations of artificial resp. short lived activity. Results are compared to standard recommendations of DIN ISO 11929.

  2. Early interim 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography is prognostically superior to international prognostic score in advanced-stage Hodgkin's lymphoma: a report from a joint Italian-Danish study

    DEFF Research Database (Denmark)

    Loft, Annika; Gallamini, Andrea; Hutchings, Martin

    2007-01-01

    PURPOSE: Starting from November 2001, 260 newly diagnosed patients with Hodgkin's lymphoma (HL) were consecutively enrolled in parallel Italian and Danish prospective trials to evaluate the prognostic role of an early interim 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG...

  3. Pertussis Toxin Exploits Host Cell Signaling Pathways Induced by Meningitis-Causing E. coli K1-RS218 and Enhances Adherence of Monocytic THP-1 Cells to Human Cerebral Endothelial Cells

    Science.gov (United States)

    Starost, Laura Julia; Karassek, Sascha; Sano, Yasuteru; Kanda, Takashi; Kim, Kwang Sik; Dobrindt, Ulrich; Rüter, Christian; Schmidt, Marcus Alexander

    2016-01-01

    Pertussis toxin (PTx), the major virulence factor of the whooping cough-causing bacterial pathogen Bordetella pertussis, permeabilizes the blood–brain barrier (BBB) in vitro and in vivo. Breaking barriers might promote translocation of meningitis-causing bacteria across the BBB, thereby facilitating infection. PTx activates several host cell signaling pathways exploited by the neonatal meningitis-causing Escherichia coli K1-RS218 for invasion and translocation across the BBB. Here, we investigated whether PTx and E. coli K1-RS218 exert similar effects on MAPK p38, NF-κB activation and transcription of downstream targets in human cerebral endothelial TY10 cells using qRT-PCR, Western blotting, and ELISA in combination with specific inhibitors. PTx and E. coli K1-RS218 activate MAPK p38, but only E. coli K1-RS218 activates the NF-κB pathway. mRNA and protein levels of p38 and NF-κB downstream targets including IL-6, IL-8, CxCL-1, CxCL-2 and ICAM-1 were increased. The p38 specific inhibitor SB203590 blocked PTx-enhanced activity, whereas E. coli K1-RS218’s effects were inhibited by the NF-κB inhibitor Bay 11-7082. Further, we found that PTx enhances the adherence of human monocytic THP-1 cells to human cerebral endothelial TY10 cells, thereby contributing to enhanced translocation. These modulations of host cell signaling pathways by PTx and meningitis-causing E. coli support their contributions to pathogen and monocytic THP-1 cells translocation across the BBB. PMID:27754355

  4. Pertussis Toxin Exploits Host Cell Signaling Pathways Induced by Meningitis-Causing E. coli K1-RS218 and Enhances Adherence of Monocytic THP-1 Cells to Human Cerebral Endothelial Cells

    Directory of Open Access Journals (Sweden)

    Laura Julia Starost

    2016-10-01

    Full Text Available Pertussis toxin (PTx, the major virulence factor of the whooping cough-causing bacterial pathogen Bordetella pertussis, permeabilizes the blood–brain barrier (BBB in vitro and in vivo. Breaking barriers might promote translocation of meningitis-causing bacteria across the BBB, thereby facilitating infection. PTx activates several host cell signaling pathways exploited by the neonatal meningitis-causing Escherichia coli K1-RS218 for invasion and translocation across the BBB. Here, we investigated whether PTx and E. coli K1-RS218 exert similar effects on MAPK p38, NF-κB activation and transcription of downstream targets in human cerebral endothelial TY10 cells using qRT-PCR, Western blotting, and ELISA in combination with specific inhibitors. PTx and E. coli K1-RS218 activate MAPK p38, but only E. coli K1-RS218 activates the NF-κB pathway. mRNA and protein levels of p38 and NF-κB downstream targets including IL-6, IL-8, CxCL-1, CxCL-2 and ICAM-1 were increased. The p38 specific inhibitor SB203590 blocked PTx-enhanced activity, whereas E. coli K1-RS218’s effects were inhibited by the NF-κB inhibitor Bay 11-7082. Further, we found that PTx enhances the adherence of human monocytic THP-1 cells to human cerebral endothelial TY10 cells, thereby contributing to enhanced translocation. These modulations of host cell signaling pathways by PTx and meningitis-causing E. coli support their contributions to pathogen and monocytic THP-1 cells translocation across the BBB.

  5. The Ks-band Tully–Fisher Relation – A Determination of the Hubble Parameter from 218 ScI Galaxies and 16 Galaxy Clusters

    Indian Academy of Sciences (India)

    David G. Russell

    2009-06-01

    The value of Hubble parameter (H0) is determined using the morphologically type dependent Ks-band Tully–Fisher Relation (K-TFR). The slope and zero point are determined using 36 calibrator galaxies with ScI morphology. Calibration distances are adopted from direct Cepheid distances, and group or companion distances derived with the Surface Brightness Fluctuation Method or Type Ia Supernova. It is found that a small morphological type effect is present in the K-TFR such that ScI galaxies are more luminous at a given rotational velocity than Sa/Sb galaxies and Sbc/Sc galaxies of later luminosity classes. Distances are determined to 16 galaxy clusters and 218 ScI galaxies with minimum distances of 40.0 Mpc. From the 16 galaxy clusters a weighted mean Hubble parameter of H0 = 84.2 ± 6 km s-1 Mpc-1 is found. From the 218 ScI galaxies a Hubble parameter of H0 = 83.4 ± 8 km s-1 Mpc-1 is found. When the zero point of K-TFR is corrected to account for recent results that find a Large Magellanic Cloud distance modulus of 18.39 × 0.05, a Hubble parameter of 88.0 ± 6 km s-1 Mpc-1 is found. Effects from Malmquist bias are shown to be negligible in this sample as galaxies are restricted to a minimum rotational velocity of 150 km s-1. It is also shown that the results of this study are negligibly affected by the adopted slope for the K-TFR, inclination binning, and distance binning. A comparison with the results of the Hubble Key Project (Freedman et al. 2001) is made. Discrepancies between the K-TFR distances and the HKP I-TFR distances are discussed. Implications for -CDM cosmology are considered with H0 = 84 km s-1 Mpc-1. It is concluded that it is very difficult to reconcile the value of H0 found in this study with ages of the oldest globular clusters and matter density of the universe derived from galaxy clusters in the context of -CDM cosmology.

  6. Association of trytophan hydroxylase gone A218C and serotonin transporter gone polymorphism with essential hypertension in Chinese northern Hart population%色氨酸羟化酶基因A218C及5-羟色胺转运体基因多态性与原发性高血压

    Institute of Scientific and Technical Information of China (English)

    夏大胜; 卢成志; 郭倩玉; 宋衍秋; 李超; 徐建强; 张峰

    2009-01-01

    Objective To investigate the relationship between trytophan hydroxylase (TPH) gene A218C in intren 7 and 5-hydroxytryptamine transporter (5-HTT) gene variable number tandem repeat (VNTR) in intron 2 and gene-linked polymorphic region (LPR) deletion/iusertion polymorphism and essential hypertension (EH) in Chinese northern Han population.Methods A total of 280 EH patients and 200 normoteusive controls were genotyped using polymerase chain reaction-restriction fragment length polymorphism technique.Results There were no significant differences in the frequencies of the genotypes and alleles of TPH gene A218C and 5-HTTVNTR between EH patents and controls (all P > 0.05).The genotype frequencies of SS,LS and LL in the 5-HTTLPR polymorphism was 68%,29% and 3% in EH patients,53% ,37% and 10% in the controls respectively (P 0.05).5-HTTLPR多态的SS、LS及LL基因型在EH组分布频率为68%,29%,3%,在对照组分别为53%,37%和10%(P<0.01);S、L等位基因在EH组分布频率为82%和18%,在对照组分别为72%和28%(P<0.01).与L等位基因携带者(LS+LL)相比,SS纯合子EH患病风险显著增加(OR=1.90,95%CI为1.31~2.77,P=0.001).logistic回归分析校正年龄、性别、体质指数、血脂、空腹血糖及血尿酸水平,5-HTTLPR多态SS基因型仍与EH发病危险显著相关(DR=1.47,95%CI为1.06~2.04,P=0.021).结论 5-HTTLPR的SS基因型可能与中国北方汉族人群EH的发生相关联,而TPH基因A218C和5-HTTVNTR基因多态性在中国北方汉族人群EH的发生不起主要作用.

  7. Preliminary Thermal Modeling of Hi-Storm 100S-218 Version B Storage Modules at Hope Creek Nuclear Power Station ISFSI

    Energy Technology Data Exchange (ETDEWEB)

    Cuta, Judith M.; Adkins, Harold E.

    2013-08-30

    This report fulfills the M3 milestone M3FT-13PN0810022, “Report on Inspection 1”, under Work Package FT-13PN081002. Thermal analysis is being undertaken at Pacific Northwest National Laboratory (PNNL) in support of inspections of selected storage modules at various locations around the United States, as part of the Used Fuel Disposition Campaign of the U.S. Department of Energy, Office of Nuclear Energy (DOE-NE) Fuel Cycle Research and Development. This report documents pre-inspection predictions of temperatures for four modules at the Hope Creek Nuclear Generating Station ISFSI that have been identified as candidates for inspection in late summer or early fall/winter of 2013. These are HI-STORM 100S-218 Version B modules storing BWR 8x8 fuel in MPC-68 canisters. The temperature predictions reported in this document were obtained with detailed COBRA-SFS models of these four storage systems, with the following boundary conditions and assumptions.

  8. Early Treatment Response Monitoring Using 2-Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts

    Directory of Open Access Journals (Sweden)

    Jiayi Huang

    2014-01-01

    Full Text Available Background. To determine the optimal timing and analytic method of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (PET imaging during fractionated radiotherapy (RT to predict tumor control. Methods. Ten head neck squamous cell carcinoma xenografts derived from the UT-14-SCC cell line were irradiated with 50 Gy at 2 Gy per day over 5 weeks. Dynamic PET scans were acquired over 70 minutes at baseline (week 0 and weekly for seven weeks. PET data were analyzed using standard uptake value (SUV, retention index (RI, sensitivity factor (SF, and kinetic index (Ki. Results. Four xenografts had local failure (LF and 6 had local control. Eighty scans from week 0 to week 7 were analyzed. RI and SF after 10 Gy appeared to be the optimal predictors for LF. In contrast, SUV and Ki during RT were not significant predictors for LF. Conclusion. RI and SF of PET obtained after the first week of fractionated RT were the optimal methods and timing to predict tumor control.

  9. Estimate of the radiation source term for 18F production via thick H218O targets bombarded with 18 MeV protons

    Science.gov (United States)

    Cruzate, Juan Ángel

    2015-12-01

    The positron-emitting radionuclide most important from the point of view of radiation protection is 18F. This isotope is usually produced by bombarding 18O-enriched water with protons. Currently there are few experimental data on the radiation source term generated during these reactions. In addition, presently there is no theoretical estimates of this source term, for use in radiation protection, validated by experimental data. Up till now this term is calculated by using nuclear interactions' simulation codes, such as ALICE91. An estimate of the energy spectra for neutrons and photons, induced by 18 MeV protons on H218O target, have been calculated by using MCNPX code with cross sections from release 0 of ENDF/B VII library for all materials except 18O, for which TENDL-2012 library was used. This estimate was validated against a recent experiment carried out at the Japan Atomic Energy Agency (JAEA). The calculated spectra have generally well reproduced experiments. The results show that the calculated radiation source term may be used to estimate the neutron activation of the accelerator components and the cyclotron building, to calculate the cyclotron shielding, and to carry out radiation protection evaluations in general, for the case of cyclotrons producing 18F by means of the 18O(p,n)18F nuclear reactions, for proton energies up to 18 MeV.

  10. Tropospheric water vapour isotopologue data (H216O, H218O, and HD16O) as obtained from NDACC/FTIR solar absorption spectra

    Science.gov (United States)

    Barthlott, Sabine; Schneider, Matthias; Hase, Frank; Blumenstock, Thomas; Kiel, Matthäus; Dubravica, Darko; García, Omaira E.; Sepúlveda, Eliezer; Mengistu Tsidu, Gizaw; Takele Kenea, Samuel; Grutter, Michel; Plaza-Medina, Eddy F.; Stremme, Wolfgang; Strong, Kim; Weaver, Dan; Palm, Mathias; Warneke, Thorsten; Notholt, Justus; Mahieu, Emmanuel; Servais, Christian; Jones, Nicholas; Griffith, David W. T.; Smale, Dan; Robinson, John

    2017-01-01

    We report on the ground-based FTIR (Fourier transform infrared) tropospheric water vapour isotopologue remote sensing data that have been recently made available via the database of NDACC (Network for the Detection of Atmospheric Composition Change; MUSICA/" target="_blank">ftp://ftp.cpc.ncep.noaa.gov/ndacc/MUSICA/) and via doi:10.5281/zenodo.48902. Currently, data are available for 12 globally distributed stations. They have been centrally retrieved and quality-filtered in the framework of the MUSICA project (MUlti-platform remote Sensing of Isotopologues for investigating the Cycle of Atmospheric water). We explain particularities of retrieving the water vapour isotopologue state (vertical distribution of H216O, H218O, and HD16O) and reveal the need for a new metadata template for archiving FTIR isotopologue data. We describe the format of different data components and give recommendations for correct data usage. Data are provided as two data types. The first type is best-suited for tropospheric water vapour distribution studies disregarding different isotopologues (comparison with radiosonde data, analyses of water vapour variability and trends, etc.). The second type is needed for analysing moisture pathways by means of H2O, δD-pair distributions.

  11. Magnetocaloric and thermomagnetic properties of Ni2.18Mn0.82Ga Heusler alloy in high magnetic fields up to 140 kOe

    Science.gov (United States)

    Kamantsev, Alexander P.; Koledov, Victor V.; Mashirov, Alexey V.; Dilmieva, Elvina T.; Shavrov, Vladimir G.; Cwik, Jacek; Los, Anton S.; Nizhankovskii, Victor I.; Rogacki, Krzysztof; Tereshina, Irina S.; Koshkid'ko, Yuriy S.; Lyange, Maria V.; Khovaylo, Vladimir V.; Ari-Gur, Pnina

    2015-04-01

    Measurements of the adiabatic temperature change (ΔT) and the specific heat transfer (ΔQ) of Ni2.18Mn0.82Ga Heusler alloy were taken in order to quantify the direct giant magnetocaloric effect of the alloy when it is in the vicinity of magneto-structural phase transition (PT) from paramagnetic austenite to ferromagnetic martensite, and their results are presented. A new vacuum calorimeter was used to simultaneously measure ΔT and ΔQ of magnetocaloric materials with a Bitter coil magnet in fields of up to H = 140 kOe. Other thermomagnetic properties of this alloy were investigated using standard differential scanning calorimetry and PPMS equipment. The maximal values of magnetocaloric effect in H = 140 kOe were found to be ΔT = 8.4 K at initial temperature 340 K and ΔQ = 4900 J/kg at 343 K. Using this direct method, we show that the alloy indeed demonstrates the largest value of ΔQ as compared with previously published results for direct measurements of magnetocaloric materials, even though at 140 kOe the magnetic field-induced magnetostructural PT is still not complete.

  12. Synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine and its biological evaluation in B16 melanoma-bearing mice as PET tracer for tumor imaging

    Institute of Scientific and Technical Information of China (English)

    WANG MingWei; YIN DuanZhi; LI ShiQiang; WANG YongXian

    2007-01-01

    O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), a fluorine-18 labeled analogue of tyrosine, has been synthesized and biologically evaluated in tumor-bearing mice. The whole synthesis procedure is completed within 50 min. The radiochemical yield is about 40% (no decay corrected) and radiochemical purity more than 97% after simplified solid phase extraction. [18F]FET shows rapid, high uptake and long retention in the tumor as well as low uptake in the brain. The ratios of tumor-to-muscle (T/M) and tumor-to-blood (T/B) of [18F]FET are similar to those of [18F]FDG, but the ratios of tumor-to-brain (T/Br)are 2-3 times higher than that of [18F]FDG. Autoradiography of [18F]FET demonstrates a remarkable accumulation in melanoma with high contrast. It appears to be a probable competitive candidate for melanoma imaging with PET.

  13. Synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine and its biological evaluation in B16 melanoma-bearing mice as PET tracer for tumor imaging

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    O-(2-[18F]fluoroethyl) -L-tyrosine([18F]FET) ,a fluorine-18 labeled analogue of tyrosine,has been syn-thesized and biologically evaluated in tumor-bearing mice. The whole synthesis procedure is com-pleted within 50 min. The radiochemical yield is about 40%(no decay corrected) and radiochemical purity more than 97% after simplified solid phase extraction. [18F]FET shows rapid,high uptake and long retention in the tumor as well as low uptake in the brain. The ratios of tumor-to-muscle(T/M) and tumor-to-blood(T/B) of [18F]FET are similar to those of [18F]FDG,but the ratios of tumor-to-brain(T/Br) are 2-3 times higher than that of [18F]FDG. Autoradiography of [18F]FET demonstrates a remarkable accumulation in melanoma with high contrast. It appears to be a probable competitive candidate for melanoma imaging with PET.

  14. Functional analysis of three amino acid residues of purR re-pressor, Trp147, Gln-218 and Gln-292 in Salmonella typhi-murium

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The amber mutation sites of 6 purR(am) mutants were determined bycloning and DNA sequencing. The results showed that the mutations were distributed at three different sites in PurR coding region, G721(→A), C933(→T) and C1155(→T), which respectively turn Trp-147,Gln-218 and Gln-292 of PurR into TAG terminal codon. To determine the effect of the three amino acid residues on regulatory function of PurR protein 5 different kinds of tRNA suppressor genes, Su3, Su4, Su6, Su7 and Su9 were used for creating the PurR protein variants with single amino acid substitution. The results indicated that Cys, Glu, Gly, His and Arg which substituted Trp-147 respectively all could not recover the regulation function of PurR. It confirmed that Trp-147 is a critical amino acid for the PurR function. Gln-292 substituted respectively by the same amino acids also could not recover the PurR function, demonstrating that Gln-292 is also an important amino acid residue in PurR.

  15. Asociation between hydroxylase gene A218C polymorphism and anger started as well as anger expression trait%色氨酸羟化酶基因A218C多态性与愤怒启动及表达特质的关系

    Institute of Scientific and Technical Information of China (English)

    詹向红; 侯俊林; 闫秀娟; 刘永; 李伟; 闫国立; 王友杰; 杨丽萍

    2013-01-01

    目的:探讨色氨酸羟化酶(TPH)基因A218C多态性与愤怒启动及表达特质的关系.方法:用状态特质愤怒表达量表2(STAXI-2)筛选受试者,经采血、酚-氯仿法提取DNA、PCR-LDR法基因分型后,对数据进行统计分析.结果:①高、低特质怒两组中,基因型及等位基因频率分布差异无统计学意义.②高特质怒被试3个基因型组以下得分差异有统计学意义(P<0.05,P<0.01):发怒(AX-O),女性怒的表达(AX),男性郁怒(AX-I).③低特质怒被试3个基因型组AX-I得分差异有统计学意义(P<0.05).结论:TPH基因A218C多态性与中国正常大学生中高特质怒者的发怒特质、高特质怒女性怒的表达特质、高特质怒男性郁怒特质有关,还与低特质怒者的郁怒特质有关.%Objective:To discuss the association of tryptophan hydroxylase gene A218C polymorphism and anger started as well as anger expression trait.Methods:After the subjects were selected by STAXI-2 questionnaire,blood of them was sampled,DNA was extracted by phenol-chloroform method,genotyping by PCR-LDR method,and data was statistically analyzed.Results:①There was no statistical significance of genotype and the allele frequency distribution of the subjects between the high and low trait anger groups.②For high trait anger subjects,there was statistical significance of the following scores of the subjects in three genotype groups (P<0.05):anger expression-out (AX-O),anger expression (AX) of female,anger expression-in (AX-I) of male.③For low trait anger subjects,there was statistical significance of the scores of anger expression-in of the subjects in three genotype groups (P<0.05).Conclusion:There was the association of TPH gene A218C polymorphism with the following anger traits of normal college students with high trait anger in China:anger expression-out trait,anger expression trait of female,anger expression-in trait of male.The locus polymorphlsm was also related to the anger

  16. 孟鲁司特联合沙美特罗替卡松治疗218例支气管炎哮喘的可行性探究%The Feasibility Study of the Treatment of 218 Cases of Bronchitis Asthma by Montelukast Combined with Salmeterol

    Institute of Scientific and Technical Information of China (English)

    高晓婷

    2015-01-01

    目的:探讨孟鲁司特联合沙美特罗替卡松治疗支气管炎哮喘临床疗效。方法选取218例支气管炎患者作为研究对象,分为观察组对照组,各109例。观察组采用孟鲁斯特联合沙美特罗替卡松;对照组采用沙美特罗替卡松。比较两组肺功能情况和不良反应情况。结果观察组治疗有效率为94.4%,对照组为82.6%,差异具有统计学意义(P <0.05)。观察组治疗后肺功能改善情况优于对照组。结论采用孟鲁司特联合沙美特罗替卡松治疗支气管炎哮喘具有临床效果。%Objective To study clinical curative effect of montelukast combined with Shah Mette Lo Tikason to treat bronchitis asthma.MethodsTo choose 218 cases of bronchitis patients as the research object.They were divided into the observation group and the control group.The observation group treated with meng LuSi combined with salmeterol. The control group used salmeterol .Results The observation group treatment effective rate was 94.4%,the control group was 82.6%,and the difference statisticaly significant(P < 0.05).Conclusion The meng LuSi combined with salmeterol for treatment of bronchitis asthma is worthy of popularization and application.

  17. Phase structure and hydrogen storage properties of REMg8.35Ni2.18Al0.21 (RE=La, Ce, Pr, and Nd) hydrogen storage alloys

    Institute of Scientific and Technical Information of China (English)

    刘岩青; 韩树民; 扈琳; 刘宝忠; 赵鑫; 贾彦虹

    2013-01-01

    REMg8.35Ni2.18Al0.21 (RE=La, Ce, Pr, and Nd) alloys were prepared by induction melting and following annealing. X-ray diffraction (XRD) and scanning electron microscopy (SEM) results showed that the alloys were composed of Mg2Ni, (La, Pr, Nd)Mg2Ni, (La, Ce)2Mg17, (Ce, Pr, Nd)Mg12 and Ce2Ni7 phases. The above phases were disproportioned into Mg2NiH4, MgH2 and REHx (x=2.51 or 3) phases in hydriding. CeH2.51 phase transformed into CeH2.29 phase in dehydriding, whereas LaH3, PrH3 and NdH3 phases re-mained unchanged. The PrMg8.41Ni2.14Al0.20 alloy had the fastest hydriding kinetics and the highest dehydriding plateau pressure while the CeMg8.35Ni2.18Al0.21 alloy presented the best hydriding/dehydriding reversibility. The onset hydrogen desorption tempera-ture of the CeMg8.35Ni2.18Al0.21 hydride decreased remarkably owing to the phase transformation between the CeH2.51 and the CeH2.29.

  18. 49 CFR 571.218 - Standard No. 218; Motorcycle helmets.

    Science.gov (United States)

    2010-10-01

    ... specified in S6.4, and tested in accordance with S7.1, S7.2, and S7.3. S5.1Impact attenuation. When an impact attenuation test is conducted in accordance with S7.1, all of the following requirements shall be met: (a) Peak accelerations shall not exceed 400g; (b) Accelerations in excess of 200g shall...

  19. Sick-leave track record and other potential predictors of a disability pension. A population based study of 8,218 men and women followed for 16 years

    Directory of Open Access Journals (Sweden)

    Rosengren Annika

    2009-04-01

    Full Text Available Abstract Background A number of previous studies have investigated various predictors for being granted a disability pension. The aim of this study was to test the efficacy of sick-leave track record as a predictor of being granted a disability pension in a large dataset based on subjects sampled from the general population and followed for a long time. Methods Data from five ongoing population-based Swedish studies was used, supplemented with data on all compensated sick leave periods, disability pensions granted, and vital status, obtained from official registers. The data set included 8,218 men and women followed for 16 years, generated 109,369 person years of observation and 97,160 sickness spells. Various measures of days of sick leave during follow up were used as independent variables and disability pension grant was used as outcome. Results There was a strong relationship between individual sickness spell duration and annual cumulative days of sick leave on the one hand and being granted a disability pension on the other, among both men and women, after adjustment for the effects of marital status, education, household size, smoking habits, geographical area and calendar time period, a proxy for position in the business cycle. The interval between sickness spells showed a corresponding inverse relationship. Of all the variables studied, the number of days of sick leave per year was the most powerful predictor of a disability pension. For both men and women 245 annual sick leave days were needed to reach a 50% probability of transition to disability. The independent variables, taken together, explained 96% of the variation in disability pension grantings. Conclusion The sick-leave track record was the most important predictor of the probability of being granted a disability pension in this study, even when the influences of other variables affecting the outcome were taken into account.

  20. Is 2-deoxy-2-[18F]fluoro-D-glucose PET/CT acquisition from the upper thigh to the vertex of skull useful in oncological patients?

    Science.gov (United States)

    Salvatore, B.; Caprio, M.G.; Fonti, R.; D’Amico, D.; Fraioli, F.; Salvatore, M.; Pace, L.

    2015-01-01

    Aim To assess whether performing routinely 2-deoxy-2-[18F]fluoro-D-glucose PET/CT (18FDG PET/CT) scan from the upper thigh to the vertex of skull is clinically relevant. Materials and Methods: 3502 (1634 female; mean-age 60+16) consecutive patients undergoing 18FDG PET/CT were retrospectively analyzed. Patients were divided in 10 groups according to primary malignancy. Chi-square analysis was used to assess differences among proportions. A p value < 0.05 was considered significant. Results: 18FDG PET/CT was positive in head district in 130/3502 (3,7%) patients. In all patients lesions were unknown before PET/CT examination. PET/CT showed 158 positive brain/head uptake in the 130 patients. The 158 lesions were localized in: brain (43/158; 27%), bone (52/158; 33%), lymph node (1/158; 0,6%), soft tissue (55/158; 35%) and other sites (7/158; 4,4%). According to each group, patients were positive in the head district in 1.0% for Gastrointestinal Cancer (7/690), 3.0 % for Genitourinary Cancer (3/101), 3.7 % for Haemathologic Cancer (59/1590), 2.7 % for Gynaecologic Cancer (3/112), 7.8% for Head-Neck-Thyroid and Parathyroid Cancer (26/331), 3.5% for Breast Cancer (7/200), 2.6% for Lung Cancer (7/271), 3.4% for Melanoma (2/59), 7.4% for Sarcoma (2/27), 11.6% for Unknown Primary Tumour (14/121). Conclusion: Our data show a relatively high incidence of brain/head lesion in patients with Unknown Primary Tumour. PMID:25674547

  1. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.

    Directory of Open Access Journals (Sweden)

    Tuomas O Kilpeläinen

    2011-11-01

    Full Text Available The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166 and nine studies of children and adolescents (n = 19,268.All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2>0.8] and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A- allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26, but PA attenuated this effect (p(interaction  = 0.001. More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio  = 1.22/allele, 95% CI 1.19-1.25 than in the inactive group (odds ratio  = 1.30/allele, 95% CI 1.24-1.36. No such interaction was found in children and adolescents.The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.

  2. Association between Body Mass Index and Health-Related Quality of Life: The "Obesity Paradox" in 21,218 Adults of the Chinese General Population.

    Directory of Open Access Journals (Sweden)

    Yanbo Zhu

    Full Text Available There was no consistent recognition of the association between high or low body mass index (BMI and health related quality of life (HRQL. The aim of this research was to study the association between BMI and HRQL in Chinese adults, and to further explore the stability of that association in the subgroup analysis stratified by status of chronic conditions.A total of 21,218 adults aged 18 and older were classified as underweight, normal weight, overweight, class I obese, and class II obese based on their BMI. HRQL was measured by the SF-36 Health Survey. The independent impact of each BMI category on HRQL was examined through standard least squares regression by comparing the difference of SF-36 scores and the minimum clinically important differences (MCID, which was defined as 3 points.Compared to the normal weight, the class I obese was significantly associated with better HRQL scores in the mental component summary (MCS (75.1 vs. 73.4, P<0.001. The underweight had the lowest score in both the physical components summary (PCS (75.4 vs. 77.5, P<0.001 and mental components summary (MCS (71.8 vs. 73.4, P<0.001. For the MCID, the HRQL score was reduced by more than 3 points in the physical functioning for the class II obese (D=-3.43 and the general health for the underweight (D=-3.71. Stratified analyses showed a similar result in the health subjects and chronic conditions, and it was significant in the chronic conditions.The class I obese showed the best HRQL, especially in the mental domain. The worst HRQL was found in the underweight. The class II obese reduced HRQL in the physical functioning only. "Obesity paradox" was more obvious in the participants with chronic conditions.

  3. Positron Emission Tomography with 2-Deoxy-2-[18F] Fluoro-DGlucose in the Detection of Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas

    Directory of Open Access Journals (Sweden)

    Brian KP Goh

    2007-05-01

    Full Text Available A 79-year-old Indian male was admitted with upper abdominal discomfort of 1-year duration which was associated with loss of weight and appetite. Clinical examination of the abdomen did not reveal any palpable masses. Laboratory investigations including a complete blood count, liver function tests and serum amylase were unremarkable. Standard serum tumor markers were within normal limits: carbohydrate antigen (CA 19-9, 13.4 U/mL (reference range: 3-45 U/mL; carcinoembryonic antigen (CEA, 1.4 μg/L (reference range: 0.5-3.5 μg/L and alphafetoprotein, 1.3 μg/L (reference range: 1-10 μg/L. A contrast-enhanced computed tomographic (CT scan demonstrated a cystically dilated and tortuous pancreatic duct measuring 1.9 cm, suggestive of an intraductal papillary mucinous neoplasm (IPMN. The common bile duct was dilated up to the level of the ampulla and a 3.2x2.0 cm heterogeneous soft tissue mass was observed in the head of the pancreas which extended into the duodenum, suggestive of a malignant lesion (Images 1 and 2. Fusion positron emission tomography/computed tomography (PET/CT was subsequently performed with 12.7 mCi of 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG administered intravenously. A whole body PET/CT scan was performed 60 minutes later with CT data used for attenuation correction and anatomical correlation. This confirmed a metabolically active focus within the pancreatic head mass with a standard uptake value (SUVmax of 3.5 compatible with carcinoma (Image 3.

  4. Intraoperative cardiac arrest during anesthesia:a retrospective study of 218 274 anesthetics undergoing non-cardiac surgery in a US teaching hospital

    Institute of Scientific and Technical Information of China (English)

    AN Jian-xiong; Li-Ming Zhang; Erin A.Sullivan; GUO Qu-lian; John P.Williams

    2011-01-01

    Background Patient safety has been gained much more attention in recent years.The authors reviewed patients who had cardiac arrest in the operating rooms undergoing noncardiac surgery between January 1989 and December 2001 at the University of Pittsburgh Medical Center,USA.The main objectives of the study were to determine the incidence of intraoperative cardiac arrest,to identify possible causes of cardiac arrest and to explore amenable modifications.Methods With approval by the University of Pittsburgh Institutional Review Board,patients experienced cardiac arrest during surgery were retrieved from medical records,surgical operation and anesthesia records and pathological reports by searching the Medical Archival Retrieval System (MARS),a hospital electronic searching system.Cases of cardiac arrest were collected over a period of thirteen years from the Pre byteria University Hospital (PUH),USA.Results We found 23 cases of intraoperative cardiac arrests occurred in 218 274 anesthesia cases (1.1 per 10 000).Fourteen patients (60.8%) died in the operating room,leading to a mortality rate from all causes of 0.64 per 10 000 anesthetics.Immediate overall survival rate after arrest was 39% (9/23).Half of the patients (12/23) were emergency cases with 41% survival rate (5/12).One fourth of the arrests were trauma patients (6/23).Most arrest patients (87%,20/23) were American Society of Anesthesiologists Physical Status (ASA PS) Ⅳ and Ⅴ,while only three patients were ASA PS-Ⅰ,Ⅱ and Ⅲ,respectively.One case was attributable to an anesthesia-related cardiac arrest and recovered after successful resuscitation.Conclusions Most intraoperative cardiac arrests were not due to anesthesia-related causes.Anesthesia-related cardiac arrests might have a higher survival rate when compared to other possible causes of cardiac arrest in the operating room.

  5. 2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography initial staging impacts on survival in Hodgkin lymphoma

    Institute of Scientific and Technical Information of China (English)

    Juliano; J; Cerci; Camila; C; G; Linardi; Luís; F; Pracchia; José; Soares; Junior; Evelinda; Trindade; Dominique; Delbeke; Rodrigo; J; Cerci; Robert; Carr; José; C; Meneghetti; Valeria; Buccheri

    2013-01-01

    AIM:To assess the prognostic value and risk classification improvement of metabolic staging(MS)with Initial2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography(FDG-PET)in initial staging of Hodgkin’s Lymphoma(HL)patients to predict 5 years overall survival(5y-OS)and event free survival(EFS).METHODS:A total of 275 patients were included in this retrospective study,155 patients were staged with conventional anatomical staging(AS),and 120 also submitted to MS(FDG-PET).Prognostic analysis compared 5y-OS and 5y-EFS of patients staged with AS and MS.Risk-adjusted models incorporated clinical risk factors,computed tomography and FDG-PET staging.RESULTS:During the follow up of 267 evaluated patients,220(122 AS and 98 MS)achieved complete remission after first-line therapy(median follow-up:70±29 mo),treatment failure occurred in 79 patients and 34 died.The 5y-EFS for early vs advanced disease in AS patients was 79.3%and 66.7%,and 85.6%and53.6%in MS patients,respectively(P<0.01).The5y-OS for early and advanced disease with AS was91.3%and 81.5%,and 97.5%and 80.7%for patients staged with MS,respectively.Cox proportional hazards analysis demonstrated that FDG-PET added signifcant prognostic information and improved risk prediction(P=0.02).CONCLUSION:Initial staging FDG-PET could be used as an accurate and independent predictor of OS and EFS in HL,with impact in 5y-EFS and OS.

  6. Characterization of Growing Soil Bacterial Communities across a pH gradient Using H218O DNA-Stable Isotope Probing

    Science.gov (United States)

    Welty-Bernard, A. T.; Schwartz, E.

    2014-12-01

    Recent studies have established consistent relationships between pH and bacterial diversity and community structure in soils from site-specific to landscape scales. However, these studies rely on DNA or PLFA extraction techniques from bulk soils that encompass metabolically active and inactive, or dormant, communities, and loose DNA. Dormant cells may comprise up to 80% of total live cells. If dormant cells dominate a particular environment, it is possible that previous interpretations of the soil variables assumed to drive communities could be profoundly affected. We used H218O stable isotope probing and bar-coded illumina sequencing of 16S rRNA genes to monitor the response of actively growing communities to changes in soil pH in a soil microcosm over 14 days. This substrate-independent approach has several advantages over 13C or 15N-labelled molecules in that all growing bacteria should be able to make use of water, allowing characterization of whole communities. We hypothesized that Acidobacteria would increasingly dominate the growing community and that Actinobacteria and Bacteroidetes would decline, given previously established responses by these taxa to soil pH. Instead, we observed the reverse. Actinobacteria abundance increased three-fold from 26 to 76% of the overall community as soil pH fell from pH 5.6 to pH 4.6. Shifts in community structure and decreases in diversity with declining soil pH were essentially driven by two families, Streptomyceaca and Microbacteracea, which collectively increased from 2 to 40% of the entire community. In contrast, Acidobacteria as a whole declined although numbers of subdivision 1 remained stable across all soil pH levels. We suggest that the brief incubation period in this SIP study selected for growth of acid-tolerant Actinobacteria over Acidobacteria. Taxa within Actinomycetales have been readily cultured over short time frames, suggesting rapid growth patterns. Conversely, taxa within Acidobacteria have been

  7. Positron emission tomography with 2-[18F]-Fluoro-2-Deoxy-D-Glucose for initial staging of hodgkin lymphoma: a single center experience in Brazil

    Directory of Open Access Journals (Sweden)

    Juliano Julio Cerci

    2009-06-01

    Full Text Available BACKGROUND: 2-[18F]-Fluoro-2-Deoxy-D-Glucose (FDG-PET is a well established functional imaging modality for the initial staging of Hodgkin lymphoma (HL in patients from Western Europe and North America. The reliability of FDG-PET in populations of different ethnic groups is unclear, as all investigations published to date have come from developed countries. PURPOSE: The aim of the present study was to investigate the effectiveness of FDG-PET in the initial staging of HL patients in a Brazilian population. METHODS: Eighty-two patients with newly diagnosed HL were prospectively included in the study. All patients were staged with both conventional clinical staging (CCS methods, including computed tomography (CT and whole-body FDG-PET methods. A standard of reference for the nodal regions and the extranodal organs was determined using all available information, including the CCS methods, FDG-PET, the diagnostic histology and the follow-up examinations. The results of the CCS were then compared to the FDG-PET results. RESULTS: The sensitivity of FDG-PET was higher for nodal staging than that of CT (87.8% vs. 61.6%, respectively. FDG-PET was also more sensitive than CT in regard to evaluating the extranodal organs for lymphomatous involvement (96.2% vs. 40.0%, respectively. FDG-PET detected all 16 patients who were characterized by a positive bone marrow biopsy and identified an additional 4 patients with bone marrow disease. The incorporation of FDG-PET coupled with CCS in the staging procedure upstaged 20% (17/82 of the patients and downstaged 11% (9/82 of the patients. As a result of these changes in staging, 15% (13/82 of the patients would have received a different therapeutic regimen. CONCLUSIONS: The FDG-PET method is superior to CT for the detection of nodal and extra-nodal HL. The observation that the FDG-PET method upstaged the disease was the most common result (20% of patients brought about by the addition of PET to the staging algorithm

  8. N-(2-18F-氟丙酰基)-L-谷氨酰胺的合成及生物学分布%Synthesis of N-(2-18F-fluoropropionyl)-L-glutamine and its biodistribution study in mice

    Institute of Scientific and Technical Information of China (English)

    唐彩华; 唐刚华; 高思远; 刘少玉; 文富华; 聂大红

    2016-01-01

    Objective To synthesize 18F labeled N-(2-18 F-fluoropropionyl)-L-glutamine (18 F-FPGLN) for tumor PET imaging,and to perform its biodistribution study on normal mice and PC-3 tumorbearing nude mice.Methods 4-nitrophenyl-2-18F-fluoropropionate (18F-NFP) was synthesized on the MF2V-IT-I synthesizer and was purified by semi-preparative HPLC.Anhydrous 18F-NFP was added to a solution of L-glutanine t-butyl ester to synthesize 18F-FPGLN t-butyl ester,which was hydrolyzed by HCl (3 mol/L) and neutralized with NaOH (2 mol/L) solution.18F-FPGLN product was collected for further study.Biodistribution study was performed on normal Kunming mice and PC-3 prostate cancer tumor-bearing nude mice,respectively.Results 18F-FPGLN was synthesized with 10%-15% (decay uncorrected) overall radiochemical yield after 130 min of radiosynthesis.The radiochemical purity was higher than 96%.Rapid and high uptake of radiotracer was observed within the kidneys,and was quickly excreted through the urinary bladder.The uptake in kidney reached (35.0±1.2) %ID/g at 5 min post-injection,and descended to (1.5±0.3) %ID/g at 120 min.The liver,lung,heart and small intestine showed relatively moderate uptake of radioactivity.The uptake in the pancreas,muscle,spleen,stomach and brain was low,and the lowest uptake of (1.5±0.3) %ID/g was found in the brain at 30 min post injection.High accumulation of 18F-FPGLN in PC-3 xenograft was observed,and the tumor/muscle ratio reached 2.07 at 60 min post injection.Conclusion A novel N-position 18F-labeled glutamine analogs 18F-FPGLN,with favorable pharmacokinetic characteristics,is synthesized successfully,which makes it possible to perform tumor PET imaging using 18F-FPGLN subsequently.%目的 合成N端标记新型肿瘤亚氨基酸类PET显像剂N-(2-18F-氟丙酰基)-L-谷氨酰胺(18F-FPGLN),并进行正常小鼠及荷PC-3前列腺癌裸鼠体内生物学分布研究.方法 首先在18F多功能合成仪中合成辅基2-18F

  9. The role of micro RNAs let7c, 100 and 218 expression and their target RAS, C-MYC, BUB1, RB, SMARCA5, LAMB3 and Ki-67 in prostate cancer

    Directory of Open Access Journals (Sweden)

    Sabrina T. Reis

    2013-05-01

    Full Text Available OBJECTIVE: The aim of this study is to verify the expression of proteins that are controlled by miR-let7c, 100 and 218 using immunohistochemistry in tissue microarray representative of localized and metastasized the lymph nodes and bone prostate cancer. METHODS: To verify the expression of proteins that are controlled by miR-let7c (C-MYC, BUB1, RAS 100 (SMARCA5, RB and 218 (LAMB3 and cell proliferation (Ki-67 we used immunohistochemistry and computerized image system ImageJ MacBiophotonics in three tissue microarrays representative of localized prostate cancer and lymph node and bone metastases. miRNA expression was evaluated by qRT-PCR using 60 paraffin blocks to construct the tissue microarray representative of localized disease. RESULTS: RAS expression was increased in localized prostate cancer and bone metastases compared to the lymph nodes (p=0.017. RB showed an increase in expression from localized prostate cancer to lymph node and bone metastasis (p=0.036. LAMB3 was highly expressed in localized and lymph node metastases (p<0.001. Cell proliferation evaluated by Ki-67 showed an increase from localized prostate cancer to metastases (p<0.001. We did not found any relationship between C-MYC (p=0.253, BUB1 (p=0.649 and SMARCA5 (p=0.315 protein expression with prognosis or tumor behavior. CONCLUSION: We found that the expression of RAS, RB, LAMB3 and Ki-67 changed in the different stages of prostate cancer. Furthermore, we confirmed the overexpression of the miRNAs let7c, 100 and 218 in localized prostate cancer but failed to show the control of protein expression by the putative controller miRNAs using immunohistochemistry.

  10. A Fully Automated Radiosynthesis of [18F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[18F]Fluoroethyl Tosylate

    Directory of Open Access Journals (Sweden)

    Gjermund Henriksen

    2013-06-01

    Full Text Available We have developed a new method for automated production of 2-[18F]fluoroethyl tosylate ([18F]FETos that enables 18F-alkylation to provide PET tracers with high chemical purity. The method is based on the removal of excess ethylene glycol bistosylate precursor by precipitation and subsequent filtration and purification of the filtrate by means of solid phase extraction cartridges (SPE. The method is integrated to a single synthesis module and thereby provides the advantage over previous methods of not requiring HPLC purification, as demonstrated by the full radiosynthesis of the potent opioid receptor PET tracer [18F]fluoroethyldiprenorphine.

  11. The H2(18O) enrichment of the leaf water of tropic trees: comparison of species from the tropical rain forest and the semi-arid region in Brazil.

    Science.gov (United States)

    Zundel, G; Miekeley, W; Grisi, B M; Förstel, H

    1978-08-10

    The H2(18O) enrichment, delta, in the water of leaves from four Brazilian trees, was studied. In all trees the leaf water showed a periodic variation in delta, with a maximum in the early afternoon and a minimum around 6 a.m. In general delta was found to be either higher or lower than the stationary enrichment which is supposed to depend only on the relative atmospheric humidity. This effect is due to the slow response of the system to variations of the humidity. For a special case, where steady-state conditions could be anticipated, the kinetic enrichment was obtained to 20 +/- 3%, which agrees with theoretical predictions.

  12. Vapor-liquid equilibrium data for the carbon dioxide and oxygen (CO2 + O2) system at the temperatures 218, 233, 253, 273, 288 and 298 K and pressures up to 14 MPa

    OpenAIRE

    Westman, Snorre Foss; Stang, Hans Georg Jacob; Løvseth, Sigurd W.; Austegard, Anders; Snustad, Ingrid; Ertesvåg, Ivar S.

    2015-01-01

    Accurate thermophysical data for the CO2-rich mixtures relevant for carbon capture, transport and storage (CCS) are essential for the development of the accurate equations of state (EOS) and models needed for the design and operation of the processes within CCS. Vapor-liquid equilibrium measurements for the binary system CO2+O2 are reported at 218, 233, 253, 273, 288 and 298 K, with estimated standard uncertainties of maximum 8 mK in temperature, maximum 3 kPa in pressure, and max...

  13. 电穿孔与脂质体 lipofectamine 转染 miR -218进入肝癌细胞效率的比较%Comparison study of the transfection efficiency between electroporation and lipofectamin-etransfection on human hepatocarcinoma cells

    Institute of Scientific and Technical Information of China (English)

    蔡磊; 李艳; 郭曼; 连肖; 杨学文; 王文斌

    2015-01-01

    目的:比较采用电穿孔和脂质体 lipofectamine 两种方法转染人肝癌细胞的效率优劣。方法:分别采用电穿孔和脂质体转染 miR -218进入人肝癌细胞 HepG2,采用 RT -PCR、Western blot、流式细胞仪、Tunel 检测等方法比较两种方法的转染后对人肝癌细胞的影响。结果:采用两种方法都可以成功将 miR -218转染进人肝癌细胞 HepG2中,降低了 HepG2中 miR -218靶基因 RNA 编辑酶 ADAR1的表达,使得细胞凋亡增加,但电穿孔转染组效率更高。结论:电穿孔转染是一种安全、高效的转染方法,值得推广。%Objective:To compare the transfection efficiencies of miR -218 into human hepatocarcinoma cells HepG2 by electroporation or lipofectamine.Methods:miR -218 was transfected either by electroporation or by lipo-fectamine.Cells were collected,and then the condition of HepG2 cells were detected by RT -PCR,Western blot,Flow Cytometry and Tunel test.Results:Both two methods could transfect miR -218 into HepG2 swimmingly,leading to the increase of apoptosis,with the apporach of electroporation had abetter effect.Conclusion:Electroporation transfection is a safe,effective approach,which is worthy promotion.

  14. Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide.

    Science.gov (United States)

    Morris, Olivia; Gregory, J; Kadirvel, M; Henderson, Fiona; Blykers, A; McMahon, Adam; Taylor, Mark; Allsop, David; Allan, Stuart; Grigg, J; Boutin, Herve; Prenant, Christian

    2016-10-01

    2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [(18)F]RI-OR2-TAT has been measured in Wistar rats.

  15. Synthesis and evaluation of N-(5-fluoro-2-phenoxyphenyl)-N-(2-[(18)F]fluoromethoxy-d(2)-5-methoxybenzyl)acetamide: a deuterium-substituted radioligand for peripheral benzodiazepine receptor.

    Science.gov (United States)

    Zhang, Ming-Rong; Maeda, Jun; Ito, Takehito; Okauchi, Takashi; Ogawa, Masanao; Noguchi, Junko; Suhara, Tetsuya; Halldin, Christer; Suzuki, Kazutoshi

    2005-03-01

    N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(18)F]fluoromethoxy-d(2)-5-methoxybenzyl)acetamide ([(18)F]2) is a potent ligand (IC(50): 1.71 nM) for peripheral benzodiazepine receptor (PBR). However, in vivo evaluation on rodents and primates showed that this ligand was unstable and rapidly metabolized to [(18)F]F(-) by defluorination of the [(18)F]fluoromethyl moiety. In this study, we designed a deuterium-substituted analogue, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[(18)F]fluoromethoxy-d(2)-5-methoxybenzyl)acetamide ([(18)F]5) as a radioligand for PBR to reduce the in vivo metabolic rate of the non-deuterated [(18)F]2. The design principle was based on the hypothesis that the deuterium substitution may reduce the rate of defluorination initiated by cleavage of the C-H bond without altering the binding affinity for PBR. The non-radioactive 5 was prepared by reacting diiodomethane-d(2) (CD(2)I(2), 6) with a phenol precursor 7, followed by treatment with tetrabutylammonium fluoride. The ligand [(18)F]5 was synthesized by the alkylation of 7 with [(18)F]fluoromethyl iodide-d(2) ([(18)F]FCD(2)I, [(18)F]9). Compound 5 displayed a similar in vitro affinity to PBR (IC(50): 1.90 nM) with 2. In vivo evaluation demonstrated that [(18)F]5 was metabolized by defluorination to [(18)F]F(-) as a main radioactive component, but its metabolic rate was slower than that of [(18)F]2 in the brain of mice. The deuterium substitution decreased the radioactivity level of [(18)F]5 in the bone of mouse, augmented by the percentage of specific binding to PBR in the rat brain determined by ex vivo autoradiography. However, the PET image of [(18)F]5 for monkey brain showed high radioactivity in the brain and skull, suggesting a possible species difference between rodents and primates.

  16. Automated production at the curie level of no-carrier-added 6-[(18)F]fluoro-L-dopa and 2-[(18)F]fluoro-L-tyrosine on a FASTlab synthesizer.

    Science.gov (United States)

    Lemaire, C; Libert, L; Franci, X; Genon, J-L; Kuci, S; Giacomelli, F; Luxen, A

    2015-06-15

    An efficient, fully automated, enantioselective multi-step synthesis of no-carrier-added (nca) 6-[(18)F]fluoro-L-dopa ([(18)F]FDOPA) and 2-[(18)F]fluoro-L-tyrosine ([(18)F]FTYR) on a GE FASTlab synthesizer in conjunction with an additional high- performance liquid chromatography (HPLC) purification has been developed. A PTC (phase-transfer catalyst) strategy was used to synthesize these two important radiopharmaceuticals. According to recent chemistry improvements, automation of the whole process was implemented in a commercially available GE FASTlab module, with slight hardware modification using single use cassettes and stand-alone HPLC. [(18)F]FDOPA and [(18)F]FTYR were produced in 36.3 ± 3.0% (n = 8) and 50.5 ± 2.7% (n = 10) FASTlab radiochemical yield (decay corrected). The automated radiosynthesis on the FASTlab module requires about 52 min. Total synthesis time including HPLC purification and formulation was about 62 min. Enantiomeric excesses for these two aromatic amino acids were always >95%, and the specific activity of was >740 GBq/µmol. This automated synthesis provides high amount of [(18)F]FDOPA and [(18)F]FTYR (>37 GBq end of synthesis (EOS)). The process, fully adaptable for reliable production across multiple PET sites, could be readily implemented into a clinical good manufacturing process (GMP) environment.

  17. Investigation of tumor related anemia in 10 218 patients with cancer in the digestive system%10218例消化系恶性肿瘤贫血情况调查

    Institute of Scientific and Technical Information of China (English)

    葛军娜; 于健春; 康维明; 马志强; 古应超

    2011-01-01

    目的 调查总结消化系癌的贫血发生情况.方法 回顾性收集2000年1月至2009年6月在北京协和医院住院治疗且明确诊断的消化系癌10 218例,其中食管癌1118例,胃癌2418例,十二指肠癌134例,小肠癌85例,肝细胞癌1508例,胆管癌546例,胰腺癌1242例,结肠癌1582例,直肠癌1585例.对其贫血发生情况进行分析.结果 按照中国贫血标准(血红蛋白小于120 g/L),接受调查的患者中消化系癌贫血发生率为27.5%(2813/10 218),不同肿瘤贫血发生率由高至低依次为小肠癌(64.7%)、十二指肠癌(60.5%)、结肠癌(42.6%)、胆管癌(36.6%)、胃癌(33.3%)、胰腺癌(22.6%)、直肠癌(20.4%)、肝细胞癌(18.7%)和食管癌(10.0%).在胃癌、胆管癌、胰腺癌、结肠癌和直肠癌中,贫血以高龄患者多见;在小肠癌和胆管癌,贫血以男性患者多见.但在肝细胞癌和胰腺癌中则以女性患者多见(P<0.05).结论 消化系癌易发生贫血,其中以十二指肠癌和小肠癌发生率最高,胃癌和结肠癌次之,食管癌贫血发生率最低.在某些消化系癌中,贫血发生可能与年龄和性别有关.%Objective To study the prevalence of tumor related anemia in patients with cancer in the digestive system. Methods A total of of 10 218 inpatients were diagnosed with cancer in the digestive system at the Peking Union Hospital from Janary 2000 to June 2009, which included esophageal cancer(n=1118), gastric cancer(n=2418), carcinoma of duodenum(n=134), carcinoma of small intestine(n=85), hepatocellular cancer(n= 1508), cholangiocarcinoma (n=546), pancreatic cancer (n=1242), colon cancer (n=1582), and rectal cancer (n=1585). Patients with hemolytic anemia or hepatorenal dysfunction were excluded. Data pertaining to sex, age and hemoglobin were obtained by chart review. Results According to the China criteria of anemia, the overall anemia rate was 27.5% (2813/10 218). The prevalence of anemia was 64.7% for small bowel cancer, 60.5% for duodenal

  18. 安定与胃复安组合术前用药预防和减少麻醉及手术期间呕吐反流218例临床观察

    Institute of Scientific and Technical Information of China (English)

    杨惠良; 杨祖明; 马永; 赵青; 宁选波; 肖乔香

    2004-01-01

    @@ 呕吐与反流伴随发生的大量酸性胃内容物吸入肺内引起的Mendelson综合征,仍为目前麻醉、尤其是急症麻醉手术发生严重意外的重要原因之一.近年来对呕吐与反流的机制进行了深入研究,注意到某些H2受体阻滞剂、多巴胺拮抗剂如胃复安等药可增加下食道括约肌张力(Lower esophageal sphincter LES),降低胃液pH,减少胃内容量,加速胃的排空,防止和减少麻醉手术期间呕吐反流的发生.本院于2003年6~12月对一组急症手术采用安定加胃复安作为术前用药,根据218例患者临床观察,认为效果满意,报告如下.

  19. Request for interim approval to operate Trench 94 of the 218-E-12B Burial Ground as a chemical waste landfill for disposal of polychlorinated biphenyl waste in submarine reactor compartments. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Cummins, G.D.

    1994-06-01

    This request is submitted to seek interim approval to operate a Toxic Substances Control Act (TSCA) of 1976 chemical waste landfill for the disposal of polychlorinated biphenyl (PCB) waste. Operation of a chemical waste landfill for disposal of PCB waste is subject to the TSCA regulations of 40 CFR 761. Interim approval is requested for a period not to exceed 5 years from the date of approval. This request covers only the disposal of small 10 quantities of solid PCB waste contained in decommissioned, defueled submarine reactor compartments (SRC). In addition, the request applies only to disposal 12 of this waste in Trench 94 of the 218-E-12B Burial Ground (Trench 94) in the 13 200 East Area of the US Department of Energy`s (DOE) Hanford Facility. Disposal of this waste will be conducted in accordance with the Compliance 15 Agreement (Appendix H) between the DOE Richland Operations Office (DOE-RL) and 16 the US Environmental Protection Agency (EPA), Region 10. During the 5-year interim approval period, the DOE-RL will submit an application seeking final 18 approval for operation of Trench 94 as a chemical waste landfill, including 19 any necessary waivers, and also will seek a final dangerous waste permit from 20 the Washington State Department of Ecology (Ecology) for disposal of lead 21 shielding contained in the SRCS.

  20. Lipidomics and H218O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio embryos

    Directory of Open Access Journals (Sweden)

    Melissa Q. McDougall

    2016-08-01

    Full Text Available We hypothesized that vitamin E (α-tocopherol is required by the developing embryonic brain to prevent depletion of highly polyunsaturated fatty acids, especially docosahexaenoic acid (DHA, 22:6, the loss of which we predicted would underlie abnormal morphological and behavioral outcomes. Therefore, we fed adult 5D zebrafish (Danio rerio defined diets without (E− or with added α-tocopherol (E+, 500 mg RRR-α-tocopheryl acetate/kg diet for a minimum of 80 days, and then spawned them to obtain E− and E+ embryos. The E− compared with E+ embryos were 82% less responsive (p<0.01 to a light/dark stimulus at 96 h post-fertilization (hpf, demonstrating impaired locomotor behavior, even in the absence of gross morphological defects. Evaluation of phospholipid (PL and lysophospholipid (lyso-PL composition using untargeted lipidomics in E− compared with E+ embryos at 24, 48, 72, and 120 hpf showed that four PLs and three lyso-PLs containing docosahexaenoic acid (DHA, including lysophosphatidylcholine (LPC 22:6, required for transport of DHA into the brain, p<0.001, were at lower concentrations in E− at all time-points. Additionally, H218O labeling experiments revealed enhanced turnover of LPC 22:6 (p<0.001 and three other DHA-containing PLs in the E− compared with the E+ embryos, suggesting that increased membrane remodeling is a result of PL depletion. Together, these data indicate that α-tocopherol deficiency in the zebrafish embryo causes the specific depletion and increased turnover of DHA-containing PL and lyso-PLs, which may compromise DHA delivery to the brain and thereby contribute to the functional impairments observed in E− embryos.

  1. 29 CFR 1910.218 - Forging machines.

    Science.gov (United States)

    2010-07-01

    ... other identifier, for the forging machine which was inspected. (ii) Scheduling and recording the... other identifier, of the equipment inspected. (iii) Training personnel for the proper inspection...

  2. 50 CFR 218.23 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ... look a little to one side and out of the corners of their eyes, paying attention to the things on the... 12968-D). (E) After sunset and prior to sunrise, lookouts shall employ Night Lookouts Techniques in... (e.g., safety or weather). (H) Naval vessels shall maneuver to keep at least 500 yds (460 m)...

  3. 50 CFR 218.13 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ..., paying attention to the things on the outer edges of their field of vision. Lookouts shall also have... Lookouts Techniques in accordance with the Lookout Training Handbook (NAVEDTRA 12968-D). (F) While in... to keep at least 500 yds (460 m) away from any observed whale and avoid approaching whales...

  4. 50 CFR 218.4 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ..., paying attention to the things on the outer edges of their field of vision. Lookouts shall also have... Lookouts Techniques in accordance with the Lookout Training Handbook (NAVEDTRA 12968-D). (F) While in... maneuver to keep at least 500 yds (460 m) away from any observed whale and avoid approaching whales...

  5. 36 CFR 2.18 - Snowmobiles.

    Science.gov (United States)

    2010-07-01

    ... of total snowmobile noise that exceeds 78 decibels measured on the A-weighted scale measured at 50... decibels on the A-weighted scale at 50 feet. Snowmobiles manufactured prior to July 1, 1973 shall not register more than 86 decibels on the A-weighted scale at 50 feet. All decibel measurements shall be...

  6. 31 CFR 31.218 - Enforcement.

    Science.gov (United States)

    2010-07-01

    ... is of the utmost importance. In the event a retained entity or any individual or entity providing... disqualification of the retained entity from future financial agency agreements. (4) Imposition of any other remedy... employees. In such cases, the Department of Justice may make direct and derivative use of any statements...

  7. 49 CFR 218.5 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... include supplying cabooses, locomotives, or passenger cars with items such as ice, drinking water, tools... sufficiently lighted so as to make the blue signal clearly distinguishable. Camp car means any on-track...

  8. BDML Metadata: 218 [SSBD[Archive

    Lifescience Database Archive (English)

    Full Text Available NC-SA 0.150 2a3c851a-29f8-43da-a783-3c09668238da 0.105 x 0.105 x 0.5 (micrometer), 40 (second) http://ssbd.qbic.riken.jp/data.../source/Ce_KK_P002/RNAi_T20G5.2_040909_01/ http://ssbd.qbic.riken.jp/data.../bdml/Ce_KK_P002/RNAi_T20G5.2_040909_01.bdml0.15.xml http://ssbd.qbic.riken.jp/data/pdpml/Ce_KK_P00...2.pdpml0.05.xml http://ssbd.qbic.riken.jp/search/2a3c851a-29f8-43da-a783-3c09668238da/ http://ssbd.qbic.riken.jp/omero/webclient/?show=dataset-159 ...

  9. 50 CFR 218.104 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ... optical systems (such as night vision goggles) to aid in the detection of marine mammals. (vii) Aircraft...)/Mine Warfare (MIW) helicopter crews shall complete the NMFS-approved Marine Species Awareness Training... employ Night Lookouts Techniques in accordance with the Lookout Training Handbook (NAVEDTRA...

  10. Reference: 218 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available rpenes found in the Arabidopsis floral volatile blend. Two independent mutant lines with T-DNA insertions in...version of farnesyl diphosphate into over 15 sesquiterpenes in similar proportions to those found in the floral volatile blend

  11. 50 CFR 218.183 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ... will check that the Safety Zone radius around the sound source is clear of marine mammals. (x) Sonar...” (20 x 110) binoculars shall be present and in good working order to assist in the detection of marine... prior to sunrise, marine observers shall employ Night Lookout Techniques in accordance with the...

  12. Ferret thoracic anatomy by 2-deoxy-2-(18F)fluoro-D-glucose (18F-FDG) positron emission tomography/computed tomography (18F-FDG PET/CT) imaging.

    Science.gov (United States)

    Wu, Albert; Zheng, Huaiyu; Kraenzle, Jennifer; Biller, Ashley; Vanover, Carol D; Proctor, Mary; Sherwood, Leslie; Steffen, Marlene; Ng, Chin; Mollura, Daniel J; Jonsson, Colleen B

    2012-01-01

    The domestic ferret (Mustela putorius furo) has been a long-standing animal model used in the evaluation and treatment of human diseases. Molecular imaging techniques such as 2-deoxy-2-((18)F)fluoro-D-glucose ((18)F-FDG) positron emission tomography (PET) would be an invaluable method of tracking disease in vivo, but this technique has not been reported in the literature. Thus, the aim of this study was to establish baseline imaging characteristics of PET/computed tomography (CT) with (18)F-FDG in the ferret model. Twelve healthy female ferrets were anesthetized and underwent combined PET/CT scanning. After the images were fused, volumes of interest (VOIs) were generated in the liver, heart, thymus, and bilateral lung fields. For each VOI, standardized uptake values (SUVs) were calculated. Additional comparisons were made between radiotracer uptake periods (60, 90, and >90 minutes), intravenous and intraperitoneal injections of (18)F-FDG, and respiratory gated and ungated acquisitions. Pulmonary structures and the surrounding thoracic and upper abdominal anatomy were readily identified on the CT scans of all ferrets and were successfully fused with PET. VOIs were created in various tissues with the following SUV calculations: heart (maximum standardized uptake value [SUV(Max)] 8.60, mean standardized uptake value [SUV(Mean)] 5.42), thymus (SUV(Max) 3.86, SUV(Mean) 2.59), liver (SUV(Max) 1.37, SUV(Mean) 0.99), right lung (SUV(Max) 0.92, SUV(Mean) 0.56), and left lung (SUV(Max) 0.88, SUV(Mean) 0.51). Sixty- to 90-minute uptake periods were sufficient to separate tissues based on background SUV activity. No gross differences in image quality were seen between intraperitoneal and intravenous injections of (18)F-FDG. Respiratory gating also did not have a significant impact on image quality of lung parenchyma. The authors concluded that (18)F-FDG PET and CT imaging can be performed successfully in normal healthy ferrets with the parameters identified in this study. They

  13. Comparative Oncology: Evaluation of 2-Deoxy-2-[18F]fluoro-D-glucose (FDG Positron Emission Tomography/Computed Tomography (PET/CT for the Staging of Dogs with Malignant Tumors.

    Directory of Open Access Journals (Sweden)

    Stefanie M F Seiler

    Full Text Available 2-Deoxy-2-[18F]fluoro-D-glucose PET/CT is a well-established imaging method for staging, restaging and therapy-control in human medicine. In veterinary medicine, this imaging method could prove to be an attractive and innovative alternative to conventional imaging in order to improve staging and restaging. The aim of this study was both to evaluate the effectiveness of this image-guided method in canine patients with spontaneously occurring cancer as well as to illustrate the dog as a well-suited animal model for comparative oncology.Ten dogs with various malignant tumors were included in the study and underwent a whole body FDG PET/CT. One patient has a second PET-CT 5 months after the first study. Patients were diagnosed with histiocytic sarcoma (n = 1, malignant lymphoma (n = 2, mammary carcinoma (n = 4, sertoli cell tumor (n = 1, gastrointestinal stromal tumor (GIST (n = 1 and lung tumor (n = 1. PET/CT data were analyzed with the help of a 5-point scale in consideration of the patients' medical histories.In seven of the ten dogs, the treatment protocol and prognosis were significantly changed due to the results of FDG PET/CT. In the patients with lymphoma (n = 2 tumor extent could be defined on PET/CT because of increased FDG uptake in multiple lymph nodes. This led to the recommendation for a therapeutic polychemotherapy as a treatment. In one of the dogs with mammary carcinoma (n = 4 and in the patient with the lung tumor (n = 1, surgery was cancelled due to the discovery of multiple metastasis. Consequently no treatment was recommended.FDG PET/CT offers additional information in canine patients with malignant disease with a potential improvement of staging and restaging. The encouraging data of this clinical study highlights the possibility to further improve innovative diagnostic and staging methods with regard to comparative oncology. In the future, performing PET/CT not only for staging but also in therapy control could offer a

  14. Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain.

    Science.gov (United States)

    Zhang, Ming-Rong; Maeda, Jun; Ogawa, Masanao; Noguchi, Junko; Ito, Takehito; Yoshida, Yuichiro; Okauchi, Takashi; Obayashi, Shigeru; Suhara, Tetsuya; Suzuki, Kazutoshi

    2004-04-22

    To develop a positron emission tomography (PET) ligand for imaging the 'peripheral benzodiazepine receptor' (PBR) in brain and elucidating the relationship between PBR and brain diseases, four analogues (4-7) of N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)acetamide (2) were synthesized and evaluated as ligands for PBR. Of these compounds, fluoromethyl (4) and fluoroethyl (5) analogues had similar or higher affinities for PBR than the parent compound 2 (K(i) = 0.16 nM for PBR in rat brain sections). Iodomethyl analogue 6 displayed a moderate affinity, whereas tosyloxyethyl analogue 7 had weak affinity. Radiolabeling was performed for the fluoroalkyl analogues 4 and 5 using fluorine-18 ((18)F, beta(+); 96.7%, T(1/2) = 109.8 min). Ligands [(18)F]4 and [(18)F]5 were respectively synthesized by the alkylation of desmethyl precursor 3 with [(18)F]fluoromethyl iodide ([(18)F]8) and 2-[(18)F]fluoroethyl bromide ([(18)F]9). The distribution patterns of [(18)F]4 and [(18)F]5 in mice were consistent with the known distribution of PBR. However, compared with [(18)F]5, [(18)F]4 displayed a high uptake in the bone of mice. The PET image of [(18)F]4 for monkey brain also showed significant radioactivity in the bone, suggesting that this ligand was unstable for in vivo defluorination and was not a useful PET ligand. Ligand [(18)F]5 displayed a high uptake in monkey brain especially in the occipital cortex, a region with richer PBR than the other regions in the brain. The radioactivity level of [(18)F]5 in monkey brain was 1.5 times higher than that of [(11)C]2, and 6 times higher than that of (R)-(1-(2-chlorophenyl)-N-[(11)C]methyl,N-(1-methylpropyl)isoquinoline ([(11)C]1). Moreover, the in vivo binding of [(18)F]5 was significantly inhibited by PBR-selective 2 or 1, indicating that the binding of [(18)F]5 in the monkey brain was mainly due to PBR. Metabolite analysis revealed that [(18)F]4 was rapidly metabolized by defluorination to [(18)F]F(-) in the plasma and brain of

  15. Synthesis of 2'-deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation. Synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU.

    Science.gov (United States)

    Mangner, Thomas J; Klecker, Raymond W; Anderson, Lawrence; Shields, Anthony F

    2003-04-01

    An efficient and reliable synthesis of 2'-deoxy-2'-[(18)F]fluoro-beta-D-arabinofuranosyl nucleosides is presented. Overall decay-corrected radiochemical yields of 35-45% of 4 analogs, FAU, FMAU, FBAU and FIAU are routinely obtained in >98% radiochemical purity and with specific activities of greater than 3 Ci/micromol (110 MBq/micromol) in a synthesis time of approximately 3 hours. When approximately 220 mCi (8.15 GBq) of starting [(18)F]fluoride is used, 25 -30 mCi (0.93 -1.11 GBq) of product (enough to image two patients sequentially) is typically obtained.

  16. Comparisons between glucose analogue 2-deoxy-2-(18F)fluoro-D-glucose and 18F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions

    Institute of Scientific and Technical Information of China (English)

    Selene Capitanio; Francesca Bongioanni; Arnoldo Piccardo; Claudio Campus; Roberta Gonella; Lucia Tixi; Mehrdad Naseri; Michele Pennone; Vania Altrinetti; Ambra Buschiazzo; Irene Bossert; Francesco Fiz; Andrea Bruno; Andrea DeCensi; Gianmario Sambuceti; Silvia Morbelli

    2016-01-01

    AIM: To compare 2-deoxy-2-(18F)fluoro-D-glucose(18FFDG) and 18F-sodium(18F-NaF) positron emission tomography/computed tomography(PET/CT) accuracy in breast cancer patients with clinically/radiologically suspected or known bone metastases.METHODS: A total of 45 consecutive patients with breast cancer and the presence or clinical/biochemical or radiological suspicion of bone metastatic disease underwent 18F-FDG and 18F-fluoride PET/CT. Imaging results were compared with histopathology when available, or clinical and radiological follow-up of at least 1 year. For each technique we calculated: Sensitivity(Se), specificity(Sp), overall accuracy, positive and negative predictive values, error rate, and Youden’s index. Mc Nemar’s χ2 test was used to test the difference in sensitivity and specificity between the two diagnostic methods. All analyses were computed on a patient basis, and then on a lesion basis, with consideration ofthe density of independent lesions on the coregistered CT(sclerotic, lytic, mixed, no-lesions) and the divergent site of disease(skull, spine, ribs, extremities, pelvis). The impact of adding 18F-Na F PET/CT to the work-up of patients was also measured in terms of change in their management due to 18F-Na F PET/CT findings. RESULTS: The two imaging methods of 18F-FDG and 18F-fluoride PET/CT were significantly different at the patient-based analysis: Accuracy was 86.7% and 84.4%, respectively(Mc Nemar’s χ2 = 6.23, df = 1, P = 0.01). Overall, 244 bone lesions were detected in our analysis. The overall accuracy of the two methods was significantly different at lesion-based analysis(Mc Nemar’s χ2 = 93.4, df = 1, P < 0.0001). In the lesion density-based and site-based analysis, 18F-FDG PET/CT provided more accurate results in the detection of CT-negative metastasis(P < 0.002) and vertebral localizations(P < 0.002); 18F-Na F PET/CT was more accurate in detecting sclerotic(P < 0.005) and rib lesions

  17. Molecular clouds and star formation toward the Galactic plane within 216.25° ≤ l ≤ 218.75° and -0.75° ≤ b ≤ 1.25°

    Science.gov (United States)

    Gong, Y.; Mao, R. Q.; Fang, M.; Zhang, S. B.; Su, Y.; Yang, J.; Jiang, Z. B.; Xu, Y.; Wang, M.; Wang, Y.; Lu, D. R.; Sun, J. X.

    2016-04-01

    Context. Molecular clouds trace the spiral arms of the Milky Way and all its star forming regions. Large-scale mapping of molecular clouds will provide an approach to understand the processes that govern star formation and molecular cloud evolution. Aims: As a part of the Milky Way Imaging Scroll Painting (MWISP) survey, the aim is to study the physical properties of molecular clouds and their associated star formation toward the Galactic plane within 216.25° ≤ l ≤ 218.75° and -0.75° ≤ b ≤ 1.25°, which covers the molecular cloud complex S287. Methods: Using the 3 × 3 Superconducting Spectroscopic Array Receiver (SSAR) at the PMO-13.7m telescope, we performed a simultaneous 12CO (1-0), 13CO (1-0), C18O (1-0) mapping toward molecular clouds in a region encompassing 3.75 square degrees. We also make use of archival data to study star formation within the molecular clouds. Results: We reveal three molecular clouds, the 15 km s-1 cloud, the 27 km s-1 cloud, and the 50 km s-1 cloud, in the surveyed region. The 50 km s-1 cloud is resolved with an angular resolution of ~1' for the first time. Investigating their morphology and velocity structures, we find that the 27 km s-1 cloud is likely affected by feedback from the stellar association Mon OB3 and the 50 km s-1 cloud is characterized by three large expanding molecular shells. The surveyed region is mapped in C18O (1-0) for the first time. We discover seven C18O clumps that are likely to form massive stars, and 15 dust clumps based on the Bolocam Galactic Plane Survey (BGPS) archive data. Using infrared color-color diagrams, we find 56 Class I and 107 Class II young stellar object (YSO) candidates toward a slightly larger region of 5.0 square degrees. Based on the distribution of YSO candidates, an overdensity is found around the HII region S287 and the intersection of two shells; this is probably indicative of triggering. The star formation efficiency (SFE) and rate (SFR) of the 27 km s-1 cloud are

  18. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  19. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  20. Evaluation of Novel Wet Chemistry Separation and Purification Methods to Facilitate Automation of Astatine-­211 Isolation

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott [Univ. of Washington, Seattle, WA (United States)

    2016-07-19

    This research is a collaborative effort between the research groups of the PIs, Dr. D. Scott Wilbur in the Department of Radiation Oncology at the University of Washington (UW) and Matthew O’Hara at the Pacific Northwest National Laboratory (PNNL). In this report only those studies conducted at UW and the budget information from UW will be reported. A separate progress and financial report will be provided by PNNL. This final report outlines the experiments (Tasks) conducted and results obtained at UW from July 1, 2013 thru June 30, 2016 (2-­year project with 1 year no-­cost extension). The report divides the information on the experiments and results obtained into the 5 specific objectives of the research efforts and the Tasks within those objectives. This format is used so that it is easy to see what has been accomplished in each area. A brief summary of the major findings from the studies is provided below. Summary of Major Findings from Research/Training Activities at UW: Anion and cation exchange columns did not provide adequate 211At capture and/or extraction results under conditions studied to warrant further evaluation; PEG-­Merrifield resins containing mPEG350, mPEG750, mPEG2000 and mPEG5000 were synthesized and evaluated; All of the mPEG resins with different sized mPEG moieties conjugated gave similar 211At capture (>95%) from 8M HCl solutions and release with conc. NH4OH (~50-­80%), but very low quantities were released when NaOH was used as an eluent; Capture and release of 211At when loading [211At]astatate appeared to be similar to that of [211At]astatide on PEG columns, but further studies need to be conducted to confirm that; Capture of 211At on PEG columns was lower (e.g. 80-­90%) from solutions of 8M HNO3, but higher capture rates (e.g. 99%) can be obtained when 10M HNO3 is mixed with an equal quantity of 8M HCl; Addition of reductants to the 211At solutions did not appear to change the percent capture, but may have an effect on the % extracted; There was some indication that the PEG-­Merrifield resins could be saturated (perhaps with Bi) resulting in lower capture percentages, but more studies need to be done to confirm that; A target dissolution chamber, designed and built at PNNL, works well with syringe pumps so it can be used in an automated system; Preliminary semi-­automated 211At isolation studies have been conducted with full scale target dissolution and 211At isolation using a PEG column on the Hamilton automated system gave low overall recoveries, but HNO3 was used (rather than HCl) for loading the 211At and flow rates were not optimized; Results obtained using PEG columns are high enough to warrant further development on a fully automated system; Results obtained also indicate that additional studies are warranted to evaluate other types of columns for 211At separation from bismuth, which allow use of HNO3/HCl mixtures for loading and NaOH for eluting 211At. Such a column could greatly simplify the overall isolation process and make it easier to automate.

  1. 7 CFR 2.18 - Under Secretary for Food Safety.

    Science.gov (United States)

    2010-01-01

    ... programs in the agricultural sciences (7 U.S.C. 3318). (2) Related to committee management. Establish and... procurement powers; (iii) Section 104(i)(11) of the Act (42 U.S.C. 9604(i)(11)), with respect to the reduction of exposure to significant risk to human health; (iv) Section 104(j) of the Act (42 U.S.C....

  2. 50 CFR 218.5 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ..., and how many minutes before or after; (J) Distance of marine mammal from actual detonations (or target... participation shall take into account safety, logistics, and operational concerns. (iv) MMOs shall observe...

  3. 50 CFR 218.24 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... actual detonations (or target spot if not yet detonated); (K) Observed behavior—Watchstanders shall..., logistics, and operational concerns. (iv) MMOs shall observe from the same height above water as...

  4. 50 CFR 218.14 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ..., and how many minutes before or after; (J) Distance of marine mammal from actual detonations (or target... participation shall take into account safety, logistics, and operational concerns. (iv) MMOs shall observe...

  5. Dicty_cDB: AFO218 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available a and immune antigen for suppressing growth of plasmodium. 58 4e-19 6 BD183625 |B...D183625.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium. 58 4e-19

  6. 30 CFR 218.51 - How to make payments.

    Science.gov (United States)

    2010-07-01

    ... equal annual installments over a specified number of years. EFT—Electronic Funds Transfer. Any paperless... of Indian Affairs (BIA) agency or area office represented by the leases on your report or invoice document. You must include the name of the applicable BIA agency or area office on your payment. Make...

  7. Dicty_cDB: VFF218 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 124000-223 Immature Ovaries from field-collected Valencia Sweet Orange (Citrus sinensis (L.) Osbeck... USDA-FP_125000-394 Immature Ovaries from field-collected Valencia Sweet Orange (Citrus sinensis (L.) Osbeck

  8. 40 CFR 94.218 - Deterioration factor determination.

    Science.gov (United States)

    2010-07-01

    ... factor shall be established for each engine family and for each emission constituent applicable to that family. (b) Calculation procedures—(1) For engines not utilizing aftertreatment technology (e.g.... (iii) Engineering analysis for established technologies. In the case where an engine family...

  9. Aeronautical Engineering: A Continuing Bibliography with Indexes (Supplement 218)

    Science.gov (United States)

    1987-10-01

    Space Administration. CONFIGURATIONS Ames Research Center, Moffett Field, Calif. G. WEDEKIND and P. MANGOLD In AGARD Integrated Design V/STOL AND STOL...TIWARI, SURENDRA N. over finite wings p 556 A87-41630 p 617 A87-41230 Grid adaption for hypersonic flow VELKOFF, H. R. WEDEKIND , G. IAIAA PAPER 87-11691 p

  10. 1935 15' Quad #218 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  11. Dicty_cDB: VSF218 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available significant alignments: (bits) Value N BD092935 |BD092935.1 Methods and compositions for synthesis of long c...hain polyunsaturated fatty acids in plants. 936 0.0 1 BD082645 |BD082645.1 Methods and composition...s for synthesis of long chain polyunsaturated fatty acids. 936 0.0 1 BD082630 |BD082630.1 Methods and composition

  12. 49 CFR 218.99 - Shoving or pushing movements.

    Science.gov (United States)

    2010-10-01

    ... level of protection to that of a direct visual determination by a crewmember or other qualified employee... crossing or pedestrian crossing except when: (A) Crossing gates are in the fully lowered position; or (B) A designated and qualified employee is stationed at the crossing and has the ability to communicate with...

  13. 50 CFR 218.184 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... Beaufort sea state, wave height, swell direction, wind direction, wind speed, glare, percentage of glare... levels (energy and pressure of discharge based on distance to the source, bathymetry, oceanographic... condition (alive, injured, dead, or degree of decomposition) shall be reported immediately to the Navy...

  14. Dicty_cDB: SHD218 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ATAAAATTTT A sequence update 2002.10.25 Translated Amino Acid sequence pniih*y*infill...igcsplqrgiv**iirgittnl**ekil*sydrnfkksk eiixklkileikiylnkil Frame C: pniih*y*infillhvi***ik*nkik*nkiki*iknkk

  15. 50 CFR 218.105 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... Dead Marine Mammals. Navy personnel shall ensure that NMFS is notified immediately ((see Communication... electronic (preferably) or verbal report within fifteen calendar days after the completion of any Major... include the following information as summarized from non-major training exercises (unit-level...

  16. Body mass index cut-offs for overweight and obesity in Chinese children and adolescents aged 2-18 years%中国2~18岁儿童青少年超重和肥胖筛查体重指数界值点的研究

    Institute of Scientific and Technical Information of China (English)

    李辉; 宗心南; 季成叶; 米杰

    2010-01-01

    Objective To study the body cut-offs of mass index (BMI) for the purpose of screening overweight and obesity for Chinese children and adolescents aged 2-18 years. Methods Based on the BMI growth reference values for Chinese children aged 0-18, using the common methods to establish the BMI cut-offs for screening overweight and obesity. These methods were having the same empirical percentile or Z scores and the BMI value at 18 years consistent with adults.Three sets of BMI cut-offs, including (BMI24, BMI28) , (P85, P95) and (Z1, Z2) , were initially identified. Differences were compared on different cut-off points and prevalence rates of overweight and obesity with different BMI reference, different values and "prevalence" of overweight and obesity based on "2004 Beijing Child and Adolescent Metabolic Syndrome Study ". Cut-offs standards which recommended by the Chinese Working Group on Obesity for Children (WGOC) and by the International Obesity Task Force (IOTF) were also used. Finally the appropriate cut-offs were defined. Results Three sets of BMI cut-offs for screening overweight and obesity for Chinese children and adolescents aged 2-18 years were obtained according to the above mentioned methods for selection. The prevalence rates of overweight and obesity defined by those cut-offs appeared not to be significantly different. Compared with the WGOC, the BMI cut-off points for screening overweight and obesity for both boys and girls from our study were very close to the WGOC', but cut-off points for screening overweight for girls aged 8.5-15.5 y was 0.3-1.0 kg/m2 lower than the WGOC'. Going through the database on screening of "2004 Beijing Children's Metabolic Syndrome Survey ", the prevalence of overweight for girls was about 3.4% higher than using the cut-offs of WGOC. Conclusion Results from this study suggested that the BMI cut-offs passed through the cut-off point of BMI24 and BMI28 at 18 years was appropriate for screening overweight and obesity in

  17. Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

    Energy Technology Data Exchange (ETDEWEB)

    Green, Damian J.; Shadman, Mazyar; Jones, Jon C.; Frayo, Shani; Kenoyer, Aimee L.; Hylarides, Mark; Hamlin, Donald K.; Wilbur, D. Scott; Balkan, Ethan R.; Lin, Yukang; Miller, Brian W.; Frost, Sophia; Gopal, Ajay K.; Orozco, Johnnie J.; Gooley, Ted; Laird, Kelley L.; Till, B. G.; Back, Tom; Sandmaier, B. M.; Pagel, John M.; Press, Oliver W.

    2015-03-26

    Alpha emitting radionuclides release a large amount of energy within a few cell diameters and may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD) conditions in which micrometastatic disease satellites are broadly distributed. To evaluate this hypothesis, 211At conjugated 1F5 mAb (anti-CD20) was studied in both bulky lymphoma tumor xenograft and MRD animal models. Superior treatment responses to 211At conjugated 1F5 mAb were evident in the MRD setting. Lymphoma xenograft tumor bearing animals treated with doses of up to 48µCi of anti-CD20 211At-decaborate [211At-B10-1F5] experienced modest responses (0% cures but 2-3-fold prolongation of survival compared to negative controls). In contrast, 70% of animals in the MRD lymphoma model demonstrated complete eradication of disease when treated with 211At-B10-1F5 at a radiation dose that was less than one-third (15 µCi) of the highest dose given to xenograft animals. Tumor progression among untreated control animals in both models was uniformly lethal. After 130 days, no significant renal or hepatic toxicity is observed in the cured animals receiving 15 µCi of 211At-B10-1F5. These findings suggest that in a MRD lymphoma model, where isolated cells and tumor microclusters prevail, α-emitters may be uniquely efficacious.

  18. Adjustable valves in normal-pressure hydrocephalus: a retrospective study of 218 patients

    DEFF Research Database (Denmark)

    Zemack, G.; Rommer, Bertil Roland

    2008-01-01

    OBJECTIVE: We sought to assess the value of adjusting shunt valve opening pressure, complications, and outcomes with the use of an adjustable shunt valve in the treatment of patients with normal-pressure hydrocephalus (NPH). METHODS: In a single-center retrospective study, 231 adjustable valves...

  19. Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer

    DEFF Research Database (Denmark)

    Hoei-Hansen, Christina E; Holm, Mette; Rajpert-De Meyts, Ewa

    2003-01-01

    patients, areas with immature and morphologically distorted tubules were also noted. Spermatogenesis was qualitatively normal in 51.4%, whereas 11.5% had very poor or absent spermatogenesis. It is concluded that microscopic testicular dysgenesis is a frequent feature in contralateral biopsies from patients...

  20. 30 CFR 250.218 - What air emissions information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... when applicable, nitrogen oxides (NOX), carbon monoxide (CO), and volatile organic compounds (VOC) that... modeling, you must use the guidelines in Appendix W of 40 CFR part 51 with a model approved by the Director...) Modeling report. A modeling report or the modeling results (if § 250.303 requires you to use an...

  1. 23 CFR 450.218 - Self-certifications, Federal findings, and Federal approvals.

    Science.gov (United States)

    2010-04-01

    ... 23 U.S.C., regarding the prohibition of discrimination based on gender; and (10) Section 504 of the... discrimination on the basis of race, color, creed, national origin, sex, or age in employment or business... part 93; (8) The Older Americans Act, as amended (42 U.S.C. 6101), prohibiting discrimination on...

  2. 29 CFR 779.218 - Methods to accomplish “unified operation.”

    Science.gov (United States)

    2010-07-01

    ... many instances where several establishments, persons, corporations, or other business organizations, join together to perform some or all of their activities as a unified business or business system. They may accomplish such unification through agreements, franchises, grants, leases, or other...

  3. Yeast Interacting Proteins Database: YGR218W, YDL065C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available PEX19 Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), bin...ith this bait as prey (0) Prey ORF YDL065C Prey gene name PEX19 Prey description Chaperone and import receptor for newly-synthesized

  4. Heterogeneous seeding of HET-s(218–289) and the mutability of prion structures

    Energy Technology Data Exchange (ETDEWEB)

    Wan, William; Stubbs, Gerald

    2014-02-18

    One fundamental property of prions is the formation of strains—prions that have distinct biological effects, despite a common amino acid sequence. The strain phenomenon is thought to be caused by the formation of different molecular structures, each encoding for a particular biological activity. While the precise mechanism of the formation of strains is unknown, they tend to arise following environmental changes, such as passage between different species. One possible mechanism discussed here is heterogeneous seeding; the formation of a prion nucleated by a different molecular structure. While heterogeneous seeding is not the only mechanism of prion mutation, it is consistent with some observations on species adaptation and drug resistance. Heterogeneous seeding provides a useful framework to understand how prions can adapt to new environmental conditions and change biological phenotypes.

  5. Using Interactive Videodiscs in Open University Courses. I.E.T. Papers on Broadcasting No. 218.

    Science.gov (United States)

    Fuller, Robert G., Ed.

    This nine-paper collection from a June 1983 Open University (OU) campus workshop in Milton Keynes, England, describes an interactive video project developed for an OU undergraduate course, T252, Introduction to Engineering Materials, and discusses varied aspects of interactive videodisc program development. The following papers are included:…

  6. Environmental Assessment: Demolish Buildings 212, 218, 819, 820 at Grand Forks Air Force Base

    Science.gov (United States)

    2007-01-31

    View Nature Preserve” has been developed to restore a part of the native tallgrass prairie that once was dominant in this region. Plants thriving in...and many native wildflower species. The Grand Forks AFB Natural Resources Manager and volunteers installed a butterfly garden in the Prairie View...characterized as typical prairie potholes found within the northern plains ecoregion. Wetlands on Grand Forks AFB occur frequently in drainage

  7. Calibration of ground-based lidar instrument WLS7-218

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Wagner, Rozenn

    This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbine at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement uncertaint......This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbine at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement...... uncertainties provided by measurement standard and corresponding lidar wind speed indications with associated measurement uncertainties. The lidar calibration concerns the 10 minute mean wind speed measurements. The comparison of the lidar measurements of the wind direction with that from wind vanes...

  8. Calibration of ground-based Lidar instrument WLS7-218

    DEFF Research Database (Denmark)

    Yordanova, Ginka; Gómez Arranz, Paula

    This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbines at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement uncertain......This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbines at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement...... uncertainties provided by measurement standard and corresponding lidar wind speed indications with associated measurement uncertainties. The lidar calibration concerns the 10 minute mean wind speed measurements. The comparison of the lidar measurements of the wind direction with that from wind vanes...

  9. Yeast Interacting Proteins Database: YGR218W, YMR124W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available ry, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR12...bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene Rows with this

  10. 38 CFR 1.218 - Security and law enforcement at VA facilities.

    Science.gov (United States)

    2010-07-01

    ... policy of the Government of the United States, or any private group, association, or enterprise. (15) Key... for monetary gain or personal property; the operation of gambling devices, a pool or lottery; or the...-emitting weapons, $200. (41) Unauthorized possession, manufacture, or use of keys or barrier card-type...

  11. Structure of Even-Even 218-230 Ra Isotopes within the Interacting Boson Approximation Model

    Directory of Open Access Journals (Sweden)

    Diab S. M.

    2008-01-01

    Full Text Available A good description of the excited positive and negative parity states of radium nuclei (Z=88, N=130-142 is achieved using the interacting boson approximation model (IBA-1. The potential energy surfaces, energy levels, parity shift, electromagnetic transition rates B(E1, B(E2 and electric monopole strength X(E0/E2 are calculated for each nucleus. The analysis of the eigenvalues of the model Hamiltonian reveals the presence of an interaction between the positive and negative parity bands. Due to this interaction the $Delta I = 1$ staggering effect, between the energies of the ground state band and the negative parity state band, is produced including beat patterns.

  12. 20 CFR 218.44 - When a remarried widow(er) annuity ends.

    Science.gov (United States)

    2010-04-01

    ...(er)— (1) Dies; (2) Becomes entitled to an old age benefit under the Social Security Act that is equal... becomes entitled to an annuity based upon age). (c) Entitlement based on “child in care.” When the... longer in care); (3) The last day of the month before the month in which the child attains age 16,...

  13. 20 CFR 218.43 - When a surviving divorced spouse annuity ends.

    Science.gov (United States)

    2010-04-01

    ... surviving divorced spouse— (1) Dies; (2) Becomes entitled to an old age benefit under the Social Security... upon age). (c) Entitlement based on “child in care.” When the surviving divorced spouse annuity is... spouse annuity ends. (a) Entitlement based on age. When the surviving divorced spouse annuity is based...

  14. 50 CFR 218.10 - Specified activity and specified geographical area and effective dates.

    Science.gov (United States)

    2010-10-01

    ... (Hellfire missile); (B) AGM-65 E/F (Maverick missile); (C) Mine Neutralization (20 lb NEW charges); (D) 5...) Missile Exercise (MISSILEX) (Air-to-Surface; Hellfire missile)—up to 350 exercises over the course of 5 years (an average of 70 per year); (C) Missile Exercise (MISSILEX) (Air-to-Surface; Maverick)—up to...

  15. 50 CFR 218.1 - Specified activity, specified geographical area and effective dates.

    Science.gov (United States)

    2010-10-01

    ... (Hellfire missile) (B) AGM-65 E/F (Maverick missile) (C) MK-83/GBU-32 (1,000 lb High Explosive bomb) (D...)—up to 100 exercises over the course of 5 years (an average of 20 per year); (D) Missile Exercise (MISSILEX) (Air-to-Surface; Hellfire missile)—up to 300 exercises over the course of 5 years (an average...

  16. 50 CFR 218.20 - Specified activity and specified geographical area and effective dates.

    Science.gov (United States)

    2010-10-01

    ... (Hellfire missile); (B) Tube-launched Optically tracked Wire-guided (TOW) missile; (C) Mine Neutralization... NEW charges)—up to 100 exercises over the course of 5 years (an average of 20 per year); (B) Missile Exercise (MISSILEX) (Air-to-Surface; Hellfire missile)—up to 40 exercises over the course of 5 years...

  17. SU-E-J-218: Novel Validation Paradigm of MRI to CT Deformation of Prostate

    Energy Technology Data Exchange (ETDEWEB)

    Padgett, K [University of Miami School of Medicine - Radiation Oncology, Miami, FL (United States); University of Miami School of Medicine - Radiology, Miami, FL (United States); Pirozzi, S; Nelson, A; Piper, J; Horvat, M [MIM Software Inc., Cleveland, OH (United States); Stoyanova, R; Dogan, N; Pollack, A [University of Miami School of Medicine - Radiation Oncology, Miami, FL (United States)

    2015-06-15

    Purpose: Deformable registration algorithms are inherently difficult to characterize in the multi-modality setting due to a significant differences in the characteristics of the different modalities (CT and MRI) as well as tissue deformations. We present a unique paradigm where this is overcome by utilizing a planning-MRI acquired within an hour of the planning-CT serving as a surrogate for quantifying MRI to CT deformation by eliminating the issues of multi-modality comparisons. Methods: For nine subjects, T2 fast-spin-echo images were acquired at two different time points, the first several weeks prior to planning (diagnostic-MRI) and the second on the same day as the planning-CT (planning-MRI). Significant effort in patient positioning and bowel/bladder preparation was undertaken to minimize distortion of the prostate in all datasets. The diagnostic-MRI was rigidly and deformably aligned to the planning-CT utilizing a commercially available deformable registration algorithm synthesized from local registrations. Additionally, the quality of rigid alignment was ranked by an imaging physicist. The distances between corresponding anatomical landmarks on rigid and deformed registrations (diagnostic-MR to planning-CT) were evaluated. Results: It was discovered that in cases where the rigid registration was of acceptable quality the deformable registration didn’t improve the alignment, this was true of all metrics employed. If the analysis is separated into cases where the rigid alignment was ranked as unacceptable the deformable registration significantly improved the alignment, 4.62mm residual error in landmarks as compared to 5.72mm residual error in rigid alignments with a p-value of 0.0008. Conclusion: This paradigm provides an ideal testing ground for MR to CT deformable registration algorithms by allowing for inter-modality comparisons of multi-modality registrations. Consistent positioning, bowel and bladder preparation may Result in higher quality rigid registrations than typically achieved which limits the impact of deformable registrations. In this study cases where significant differences exist, deformable registrations provide significant value.

  18. Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer

    DEFF Research Database (Denmark)

    Hoei-Hansen, Christina E; Holm, Mette; Rajpert-De Meyts, Ewa

    2003-01-01

    This study was prompted by a hypothesis that testicular germ cell cancer may be aetiologically linked to other male reproductive abnormalities as a part of the so-called 'testicular dysgenesis syndrome' (TDS). To corroborate the hypothesis of a common association of germ cell cancer with testicular...... dysgenesis, microscopic dysgenetic features were quantified in contralateral testicular biopsies in patients with a testicular germ cell tumour. Two hundred and eighty consecutive contralateral testicular biopsies from Danish patients with testicular cancer diagnosed in 1998-2001 were evaluated...... presenting with testicular germ cell neoplasms of the adolescent and young type. The findings therefore support the hypothesis that this cancer is part of a testicular dysgenesis syndrome. The presence of contralateral carcinoma in situ was higher in the present study than previously reported....

  19. 10 CFR Appendix C to Part 20 - Quantities 1 of Licensed Material Requiring Labeling

    Science.gov (United States)

    2010-01-01

    ... Polonium-205 1,000 Polonium-207 1,000 Polonium-210 0.1 Astatine-207 100 Astatine-211 10 Radon-220 1 Radon-222 1 Francium-222 100 Francium-223 100 Radium-223 0.1 Radium-224 0.1 Radium-225 0.1 Radium-226...

  20. 46 CFR 67.218 - Optional filing of instruments in portable document format as attachments to electronic mail.

    Science.gov (United States)

    2010-10-01

    ... recording under § 67.200 may be submitted in portable document format (.pdf) as an attachment to electronic... submitted for filing in .pdf format pertains to a vessel that is not a currently documented vessel, a... with the National Vessel Documentation Center or must be submitted in .pdf format with the...

  1. Evaluation study of calves with total artificial heart (TAH) surviving for 218-293 days of pumping.

    Science.gov (United States)

    Vasků, J; Vasků, J; Dostál, M; Guba, P; Gregor, Z; Vasků, A; Urbánek, P; Necas, J; Dolezel, S; Cídl, K

    1990-12-01

    Evaluation of five longest surviving calves among a total of 54 longterm survivors, at the Brno Research Centre was performed. These calves were treated by administration of antihypertensives and partially by electrical stimulation of the right atrium to reduce central venous pressure (CVP). Treatment for CVP was effective, as compared with two groups of 5 calves each not treated in this way, and it is assumed to be an important factor for prolongation of survival. Mineralization of driving diaphragms was present in all these calves. No preventive measures of this pathologic change were performed in this group. Another complication is hemolysis, which is partly caused by immune mechanisms initiated by administration of alpha-methyl dopa and partly by mechanical destruction due to a heavily mineralized driving diaphragm. The prevention of mineralization is another important problem for future research. Other problems, concerning the survival of TAH recipients are discussed.

  2. Raudtee müügirahast läheb 218 mln ettevõtluse toetuseks / Katrin Kurss

    Index Scriptorium Estoniae

    Kurss, Katrin

    2001-01-01

    Ilmunud ka: Delovõje Vedomosti 19. sept., lk. 6. Ettevõtluse Arendamise Sihtasutus jagab sel aastal ettevõtluse projektide toetuseks täiendavalt 160 miljonit, mis laekus Eesti Raudtee erastamisest

  3. 12 CFR 218.721 - Defined terms relating to the trust and fiduciary activities exception from the definition of...

    Science.gov (United States)

    2010-01-01

    ... management; (iv) A flat or capped per order processing fee, paid by or on behalf of a customer or beneficiary...—account-by-account test. Chiefly compensated shall mean the relationship-total compensation percentage for each trust or fiduciary account of the bank is greater than 50 percent. (2) The...

  4. Session 21.8 - Challenges and Solutions to Light Pollution, RFI and Implementing IAU Resolution 2009 B5

    Science.gov (United States)

    Green, Richard

    2016-10-01

    The closing session included a panel on the challenge of raising cultural awareness of the negative effects of light pollution and RFI, and a discussion about the means to implement the IAU Resolution on the Right to Starlight. The strongest arguments to the public are that light pollution wastes precious energy and adds greenhouse gases, and that artificial light at night can be damaging to human health and to the natural environment. As astronomers, our community is concerned that the world is blinding itself to the electromagnetic radiation connecting us to the Universe. An outcome of successful advocacy would be to create demand for commercial products that minimize blue light and upward radiation. Implementation of the resolution on the Right to Starlight has multiple aspects. The IAU, through its site protection commission, should provide a clear technical description of "astronomy friendly" lighting and specifications for protection of the near zones around optical observatories. In addition, the commission should provide reference materials for astronomers giving public presentations, provide a forum for those seeking stronger local or national regulation, seek IAU approval for endorsement of protected status of sites and regions, and support the process of gaining UNESCO World Heritage Status for observatories and their regions.

  5. 12 CFR 218.701 - Exemption from the definition of “broker” for certain institutional referrals.

    Science.gov (United States)

    2010-01-01

    ... with such person's spouse a community property or similar shared ownership interest. (2) Institutional... value of the Personal Consumption Expenditures Chain-Type Price Index (or any successor index...

  6. Compliance matrix for the mixed waste disposal facilities, trenches 31 and 34, burial ground 218-W-5. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, K.D.

    1995-05-03

    This document provides a listing of applicable regulatory requirements to the Mixed Waste Disposal trenches. After the listing of regulations to be followed is a listing of documents that show how the regulations are being implemented and followed for the Mixed Waste trenches.

  7. 12 CFR 218.760 - Exemption from definition of “broker” for banks accepting orders to effect transactions in...

    Science.gov (United States)

    2010-01-01

    ... any Web site, newspaper, magazine or other periodical, radio, television, telephone or tape recording... as defined in section 223(d) of the Internal Revenue Code (26 U.S.C. 223(d)), Archer medical...

  8. VizieR Online Data Catalog: ExoMol line list for H218O and H2

    Science.gov (United States)

    Polyansky, O. L.; Kyuberis, A. A.; Lodi, L.; Tennyson, J.; Yurchenko, S. N.; Ovsyannikov, R. I.; Zobov, N. F.

    2017-01-01

    Two line lists HotWat78 are reported, for H2O-17 and H2O-18. Each line list is in two parts, a states file and transition file. The first contains a list of rovibrational states. Each state is labelled with 3 vibrational (v1, v2, v3), 3 rotational (J, Ka, Kc) quantum numbers and a total symmetry. "-2" indicates that the quantum numbers are not available. The total degeneracy is given to facilitate the intensity calculations. Because of their size, the transitions are listed in 30 separate files (for each molecule), each containing all the transitions in a 1000cm-1 frequency range. These and their contents are ordered by increasing frequency. The name of the file includes the highest frequency in the range and the isotopic number of oxygen; thus the a-060-17.dat file contains all the transitions of H2O17 in the frequency range 5000-6000cm-1 but not including 5000cm-1. The transition files a-xxxxxx.dat contain three columns: the reference number in the energy file of the upper state, that of the lower state and the Einstein A coefficient of the transition. The energy file and the transitions files are bzipped, and need to be extracted before use. We also provide the partition functions for each molecule in the range 0 to 6000K. (5 data files).

  9. 12 CFR 218.700 - Defined terms relating to the networking exception from the definition of “broker.”

    Science.gov (United States)

    2010-01-01

    ... any other person. (c) Nominal one-time cash fee of a fixed dollar amount means a cash payment for a... dollars ($25), as adjusted in accordance with paragraph (f) of this section. (d) Job family means a group...) Inflation adjustment—(1) In general. On April 1, 2012, and on the 1st day of each subsequent 5-year...

  10. CTEPP STANDARD OPERATING PROCEDURE FOR COLLECTION OF DISLODGEABLE RESIDUES -- PUF ROLLER SAMPLES FOR PERSISTENT ORGANIC POLLUTANTS (SOP-2.18)

    Science.gov (United States)

    This SOP describes the method to collect transferable residues from indoor floor surfaces. The sampling procedures described are applicable to bare floors or covered floor surfaces, e.g., carpeting and vinyl flooring. The samples will be collected only in the day care centers o...

  11. 50 CFR 226.218 - Critical habitat for the U.S. DPS of smalltooth sawfish (Pristis pectinata).

    Science.gov (United States)

    2010-10-01

    ...) located along the southwest coast of peninsular Florida. The northern unit is the Charlotte Harbor Estuary... Preserve, which is bounded on the south by the Lee/Collier County line. Inland waters are bounded by SR-867 (McGregor Boulevard) from Punta Rassa Road to SR-80 near Fort Myers, then by SR-80 (Palm...

  12. 福山厂4号高炉218kg/t的高喷煤比

    Institute of Scientific and Technical Information of China (English)

    Maki.,A; Sakai.,A

    1997-01-01

    1994年4月末,福山厂4号高炉安装了一套能力为72t/h的喷吹煤粉系统,6个月之后,在10月份,实现了最高的喷煤比,最终成功地实现了最大喷煤比230kg/t,月平均218kg/t。之所以能达到如此高的喷煤比,其主要技术特点如下:(1)采用新设计的不同圆心双喷枪,确保高燃烧效率;(2)使用还原与熔化性能良好的球团烧结矿(HPS);(3)优化控制煤气流分布,保持炉内透气性,此外,用固定探针分析下部的

  13. Chronic diseases and life events accounted for 2-18 % population attributable risks for adult hearing loss: UK Adult Psychiatric Morbidity Survey, 2007.

    Science.gov (United States)

    Shiue, Ivy

    2016-01-01

    Links between chronic diseases and hearing loss in adults have emerged. However, previous investigations were not complete, and the role of life events was unclear. Therefore, it was aimed to examine the relationships of common chronic diseases and life events and adult hearing loss in a country-wide and population-based study. Data were retrieved from UK Adult Psychiatric Morbidity Survey, 2007, being cross-sectional, including demographics, self-reported prior health conditions and hearing loss (ever and in the last 12 months), and several major life events. Analyses included Chi square test, t test, logistic regression model, and population attributable risk estimation. People who had prior health conditions including cancer, migraine, dementia, depression, cataracts, chronic bronchitis, allergy, bowel problem, bladder problem, arthritis, muscle problem or skin problem tended to report hearing loss than their counterparts. People who have experienced major life events including post-traumatic stress disorder, serious illness of close relatives, death of family, serious problems with friends, major financial crisis, valuables stolen, being bullied, violence at home, sexual abuse or running away from home were also more likely to experience ever hearing loss problem or that in the last 12 months. 2.0-13.1 % adult hearing loss could be delayed or prevented by managing chronic diseases while 4.1-18.1 % might be delayed or prevented by minimizing the negative effects of life events. Chronic diseases and life events were associated with hearing loss in adults. Better managing lifestyle to minimize detrimental impacts in future health and nursing programs would be suggested.

  14. De Bel-Air Françoise, Migration et politique au Moyen-Orient, Beyrouth, Institut Français du Proche-Orient, 2006, 218 p.

    Directory of Open Access Journals (Sweden)

    Élisabeth Longuenesse

    2008-04-01

    Full Text Available Le fil conducteur de cet ouvrage est dans le titre : il s’agit de considérer la migration comme un phénomène fondamentalement politique, à l’encontre des approches encore largement dominantes dans les travaux portant sur les migrations au Moyen-Orient. Loin de se réduire à une question de gestion ou de régulation du marché de l’emploi d’un côté, de réponse humanitaire au problème des réfugiés fuyant la violence de l’autre, le phénomène migratoire est abordé ici sous l’angle de sa relation ave...

  15. Investigating the impact of light and water status on the exchange of COS, 13CO2, CO18O and H218O from bryophytes

    Science.gov (United States)

    Gimeno, Teresa; Royles, Jessica; Ogee, Jerome; Jones, Samuel; Burlett, Regis; West, Jason; Sauze, Joana; Wohl, Steven; Genty, Bernard; Griffiths, Howard; Wingate, Lisa

    2016-04-01

    Terrestrial surfaces are often covered by photoautotrophic communities that play a significant role in the biological fixation of C and N at the global scale. Bryophytes (mosses, liverworts and hornworts) are key members in these communities and are especially adapted to thrive in hostile environments, by growing slowly and surviving repeated dehydration events. Consequently, bryophyte communities can be extremely long-lived (>1500yrs) and can serve as valuable records of historic climate change. In particular the carbon and oxygen isotope compositions of mosses can be used as powerful proxies describing how growing season changes in atmospheric CO2 and rainfall have changed in the distant past over the land surface. Interpreting the climate signals of bryophyte biomass requires a robust understanding of how changes in photosynthetic activity and moisture status regulate the growth and isotopic composition of bryophyte biomass. Thus theoretical models predicting how changes in isotopic enrichment and CO2 discrimination respond to dehydration and rehydration are used to tease apart climatic and isotopic source signals. Testing these models with high resolution datasets obtained from new generation laser spectrometers can provide more information on how these plants that lack stomata cope with water loss. In addition novel tracers such as carbonyl sulfide (COS) can also be measured at high resolution and precision (rates were low. As the water film on the bryophyte disappeared the net rates of CO2 and COS uptake increased to a steady maximum rate whilst relative water content values remained above 100%. Thereafter, the bryophyte turned from a COS sink to a source. In this talk we will further explore how the COS exchange rate of bryophytes varies with light level and whether there is any evidence for differences in the activity of the enzyme carbonic anhydrase with light and moisture status. We also use the data to develop and test a new theoretical model of COS exchange for astomatous plants for the first time.

  16. Herschel/PACS spectroscopy of NGC 4418 and Arp 220: H2O, H2^{18}O, OH, ^{18}OH, O^0, HCN and NH3

    CERN Document Server

    González-Alfonso, E; Graciá-Carpio, J; Sturm, E; Hailey-Dunsheath, S; Lutz, D; Poglitsch, A; Contursi, A; Feuchtgruber, H; Veilleux, S; Spoon, H W W; Verma, A; Christopher, N; Davies, R; Sternberg, A; Genzel, R; Tacconi, L

    2011-01-01

    Herschel/PACS spectroscopy of the (ultra)luminous infrared galaxies NGC 4418 and Arp 220 reveals high excitation in H2O, OH, HCN, and NH3. In NGC 4418, absorption lines were detected with E_lower>800 K (H2O), 600 K (OH), 1075 K (HCN), and 600 K (NH3), while in Arp 220 the excitation is somewhat lower. While clear outflow signatures are seen in Arp 220 as has been seen in previous studies, in NGC 4418 the lines tracing its outer regions are redshifted relative to the nucleus, suggesting an inflow with Mdot~100 K) nuclear continuum components, together with a more extended and colder component that is much more prominent and massive in Arp 220. A chemical dichotomy is found in both sources: on the one hand, the nuclear regions have high H2O abundances, ~0.5x10^{-5}, and high HCN/H2O and HCN/NH3 column density ratios of 0.2-0.7 and 6-9, respectively, indicating a chemistry typical of evolved hot cores where grain mantle evaporation has occurred. On the other hand, the high OH abundance, with OH/H2O ratios of ~0....

  17. Preliminary Thermal Modeling of HI-Storm 100S-218 Version B Storage Modules at Hope Creek Cuclear Power Station ISFSI

    Energy Technology Data Exchange (ETDEWEB)

    Cuta, Judith M.; Adkins, Harold E.

    2013-08-30

    As part of the Used Fuel Disposition Campaign of the U. S. Department of Energy, Office of Nuclear Energy (DOE-NE) Fuel Cycle Research and Development, a consortium of national laboratories and industry is performing visual inspections and temperature measurements of selected storage modules at various locations around the United States. This report documents thermal analyses in in support of the inspections at the Hope Creek Nuclear Generating Station ISFSI. This site utilizes the HI-STORM100 vertical storage system developed by Holtec International. This is a vertical storage module design, and the thermal models are being developed using COBRA-SFS (Michener, et al., 1987), a code developed by PNNL for thermal-hydraulic analyses of multi assembly spent fuel storage and transportation systems. This report describes the COBRA-SFS model in detail, and presents pre-inspection predictions of component temperatures and temperature distributions. The final report will include evaluation of inspection results, and if required, additional post-test calculations, with appropriate discussion of results.

  18. Characterization of primary prostate carcinoma by anti-1-amino-2-[18F] -fluorocyclobutane-1-carboxylic acid (anti-3-[18F] FACBC) uptake

    Science.gov (United States)

    Schuster, David M; Taleghani, Pooneh A; Nieh, Peter T; Master, Viraj A; Amzat, Rianot; Savir-Baruch, Bital; Halkar, Raghuveer K; Fox, Tim; Osunkoya, Adeboye O; Moreno, Carlos S; Nye, Jonathon A; Yu, Weiping; Fei, Baowei; Wang, Zhibo; Chen, Zhengjia; Goodman, Mark M

    2013-01-01

    Anti-1-amino-3-[18F] fluorocyclobutane-1-carboxylic acid (anti-3-[18F] FACBC) is a synthetic amino acid positron emission tomography (PET) radiotracer with utility in the detection of recurrent prostate carcinoma. The aim of this study is to correlate uptake of anti-3-[18F] FACBC with histology of prostatectomy specimens in patients undergoing radical prostatectomy and to determine if uptake correlates to markers of tumor aggressiveness such as Gleason score. Ten patients with prostate carcinoma pre-radical prostatectomy underwent 45 minute dynamic PET-CT of the pelvis after IV injection of 347.8 ± 81.4 MBq anti-3-[18F] FACBC. Each prostate was co-registered to a separately acquired MR, divided into 12 sextants, and analyzed visually for abnormal focal uptake at 4, 16, 28, and 40 min post-injection by a single reader blinded to histology. SUVmax per sextant and total sextant activity (TSA) was also calculated. Histology and Gleason scores were similarly recorded by a urologic pathologist blinded to imaging. Imaging and histologic analysis were then compared. In addition, 3 representative sextants from each prostate were chosen based on highest, lowest and median SUVmax for immunohistochemical (IHC) analysis of Ki67, synaptophysin, P504s, chromogranin A, P53, androgen receptor, and prostein. 79 sextants had malignancy and 41 were benign. Highest combined sensitivity and specificity was at 28 min by visual analysis; 81.3% and 50.0% respectively. SUVmax was significantly higher (pFACBC SUVmax with Ki-67 or other IHC markers. Since there was no distinct separation between malignant and non-malignant sextants or between Gleason score levels, we believe that anti-3-[18F] FACBC PET should not be used alone for radiation therapy planning but may be useful to guide biopsy to the most aggressive lesion. PMID:23342303

  19. Characterization of primary prostate carcinoma by anti-1-amino-2-[(18)F] -fluorocyclobutane-1-carboxylic acid (anti-3-[(18)F] FACBC) uptake.

    Science.gov (United States)

    Schuster, David M; Taleghani, Pooneh A; Nieh, Peter T; Master, Viraj A; Amzat, Rianot; Savir-Baruch, Bital; Halkar, Raghuveer K; Fox, Tim; Osunkoya, Adeboye O; Moreno, Carlos S; Nye, Jonathon A; Yu, Weiping; Fei, Baowei; Wang, Zhibo; Chen, Zhengjia; Goodman, Mark M

    2013-01-01

    Anti-1-amino-3-[(18)F] fluorocyclobutane-1-carboxylic acid (anti-3-[(18)F] FACBC) is a synthetic amino acid positron emission tomography (PET) radiotracer with utility in the detection of recurrent prostate carcinoma. The aim of this study is to correlate uptake of anti-3-[(18)F] FACBC with histology of prostatectomy specimens in patients undergoing radical prostatectomy and to determine if uptake correlates to markers of tumor aggressiveness such as Gleason score. Ten patients with prostate carcinoma pre-radical prostatectomy underwent 45 minute dynamic PET-CT of the pelvis after IV injection of 347.8 ± 81.4 MBq anti-3-[(18)F] FACBC. Each prostate was co-registered to a separately acquired MR, divided into 12 sextants, and analyzed visually for abnormal focal uptake at 4, 16, 28, and 40 min post-injection by a single reader blinded to histology. SUVmax per sextant and total sextant activity (TSA) was also calculated. Histology and Gleason scores were similarly recorded by a urologic pathologist blinded to imaging. Imaging and histologic analysis were then compared. In addition, 3 representative sextants from each prostate were chosen based on highest, lowest and median SUVmax for immunohistochemical (IHC) analysis of Ki67, synaptophysin, P504s, chromogranin A, P53, androgen receptor, and prostein. 79 sextants had malignancy and 41 were benign. Highest combined sensitivity and specificity was at 28 min by visual analysis; 81.3% and 50.0% respectively. SUVmax was significantly higher (pFACBC SUVmax with Ki-67 or other IHC markers. Since there was no distinct separation between malignant and non-malignant sextants or between Gleason score levels, we believe that anti-3-[(18)F] FACBC PET should not be used alone for radiation therapy planning but may be useful to guide biopsy to the most aggressive lesion.

  20. Dynamic 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography of liver tumours without blood sampling

    DEFF Research Database (Denmark)

    Keiding, S; Munk, O L; Schiøtt, K M

    2000-01-01

    in tissue and arterial blood. We examined whether time-activity curves (TACs) based on arterial blood sampling could be replaced by TACs obtained from the descending aorta in dynamic PET scans of patients with liver tumours. The study was performed in two parts, using data from dynamic liver scans...... with arterial blood sampling in human subjects: First, data from four patients with no liver tumours and five patients with liver tumours were used as a training group. Volumes of interest were defined in the descending aorta (aorta VOIs) by four different methods. K values were calculated based...... on the corresponding TACs and compared with those based on TACs of the arterial blood sample radioactivity concentrations. The aorta VOI which gave K values that were in best agreement with the K values based on the arterial blood sample measurements was called the AORTA-VOI. Use of the AORTA-VOI was subsequently...

  1. Oxidation of methionine 216 in sheep and elk prion protein is highly dependent upon the amino acid at position 218 but is not important for prion propagation

    Science.gov (United States)

    We developed a sensitive mass spectrometry-based method of quantitating the prions present in elk and sheep. Calibration curves relating the area ratios of the selected analyte peptides and their homologous stable isotope labeled internal standards were prepared. This method was compared to the ELIS...

  2. Functional analysis of three amino acid residues of purR re-pressor, Trp147, Gln-218 and Gln-292 in Salmonella typhi-murium

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Hesheng

    2001-01-01

    [1]Zalkin, H., Nygaard, P., Escherichia coli and Salmmella typhimurium Cellular and Molecular Biology, Washington D.C: American Society for Microbiology, 1996, 561-579.[2]Maria, A. S., Choi, K. Y., Lu, F. et al., Mechanism of co-repressor mediated specific DNA binding by the purine repressor, Cell, 1995, 83: 147.[3]Choi, K. Y., Fu, L., Zalkin, H., Mutagenesis of amino acid residues required for binding of co-repressors to the purine repressor, J. Biol. Chem., 1993, 269: 24066.[4]Lu, F., Brennan, R. G., Zalkin, H., Escherichia coli purine repressor: key residues for the allsteic transition between active and inactive conformation and for inter domain signaling, Biochemistry, 1998, 37: 15680.[5]Tang Hua, Qin Junchuan, Wang Aoquan, Regulation of purine biosynthetic genes expression in Salmonella typhimurium (VI)-- Isolation and characterization of superrepressor mutants, Chinese Journal of Genetics (in Chinese), 1998, 25(2): 181.[6]Zhang Hesheng, Wang Aoquan, Regulation of purine biosynthetic genes expression in Salmonella typhimurium (X)--Isola-tion of purR(am) mutant and preliminary study of amino acid substitution, Chinese Journal of Genetics (in Chinese), 2000, 27(2): 170.[7]Davis, R. W., Roth, J. R., Advanced Bacteria Genetics, NY: Cold Spring Harbor Laboratory Press, 1984.[8]Miller, J. H., Experiments in Molecular Genetics, NY: Cold Spring Harbor Laboratory Press, 1972.[9]Sambrook, J., Fritsch, E. F., Maniatis, T., Molecular Cloning, A Laboratory Manual, NY: Cold Spring Harbor laboratory Press, 1989.[10] Katzif, S. D., Lu, C. D., Abdelal, A.T., Salmonela typhimurium purine nucleotide synthesis repressor (purR), GenBank, Ac-cession AF040636, 1998.[11] Weicket,M.J.,Adhya,S., A family of bacteria regulators homologous to Gal and Lac repressors,J.Biol.Chem.,1992,267:15869.

  3. Hyperspectral surface materials map of quadrangle 3770, Faizabad (217) and Parkhaw (218) quadrangles, Afghanistan, showing iron-bearing minerals and other materials

    Science.gov (United States)

    King, Trude V.V.; Hoefen, Todd M.; Kokaly, Raymond F.; Livo, Keith E.; Giles, Stuart A.; Johnson, Michaela R.

    2013-01-01

    This map shows the spatial distribution of selected iron-bearing minerals and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. This map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Goethite and jarosite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  4. Hyperspectral surface materials map of quadrangle 3770, Faizabad (217) and Parkhaw (218) quadrangles, Afghanistan, showing carbonates, phyllosilicates, sulfates, altered minerals, and other materials

    Science.gov (United States)

    Kokaly, Raymond F.; King, Trude V.V.; Hoefen, Todd M.; Livo, Keith E.; Giles, Stuart A.; Johnson, Michaela R.

    2013-01-01

    This map shows the spatial distribution of selected carbonates, phyllosilicates, sulfates, altered minerals, and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. The map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Epidote or chlorite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  5. 75 FR 32773 - Auction of 218-219 MHz Service and Phase II 220 MHz Service Licenses Scheduled for December 7...

    Science.gov (United States)

    2010-06-09

    ... format documents, sign language interpreters, CART, etc.) by e-mail: FCC504@fcc.gov or phone: 202-418... Commission has authorized certain site-based, low power operations on a secondary basis in the 216-220 MHz..., the service rules permit a variety of fixed, mobile, and paging services, though the opportunities...

  6. 30 CFR 218.306 - May I receive a credit against production royalties for in-kind deliveries of electricity I...

    Science.gov (United States)

    2010-07-01

    ... royalties for in-kind deliveries of electricity I provide under contract to a State or county government... electricity I provide under contract to a State or county government? (a) You may receive a credit against royalties for in-kind deliveries of electricity you provide under contract to a State or county...

  7. Investigation at Mach Numbers 2.98 and 2.18 of Axially Symmetric Free-jet Diffusion with a Ram-jet Engine

    Science.gov (United States)

    Hunczak, Henry R

    1952-01-01

    An investigation was conducted to determine the effectiveness of a free-jet diffuser in reducing the over-all pressure ratios required to operate a free jet with a large air-breathing engine as a test vehicle. Efficient operation of the free jet was determined with and without the considerations required for producing suitable engine-inlet flow conditions. A minimum operating pressure ration of 5.5 was attained with a ratio of nozzle-exit to engine-inlet area of 1.85. Operation of the free jet with unstable engine-inlet flow (buzz) is also included.

  8. Rendueles, Cesar. (2015. Capitalismo canalla: una historia del capitalismo a través de la literatura. Seix Barral: Barcelona. 218 pp.

    Directory of Open Access Journals (Sweden)

    Antón Sánchez Testas

    2015-12-01

    Full Text Available El dramático final de Las uvas de la ira, la novela más importante de Steinbeck, ha quedado tristemente olvidado después de que John Ford, en su adaptación al cine, decidiera cambiarlo por uno más apropiado para Hollywood. Después de todas las miserias que vive la familia Joad en su viaje a California, acaban protegidos de una crecida de agua en un endeble cobertizo. Hambrientos y agotados, la Gran Depresión se consuma para ellos en su definitiva desnudez material. Despojados de identidad cultural al ser desahuciados de sus tierras, nihilizados y explotados por el mercado laboral, no tienen otra cosa que sus cuerpos debilitados. Así, Rose of Sharon alimenta, con la leche materna destinada a un bebé que jamás llegará a nacer, al resto de proletarios, nadas sociales, en un alivio inmediato de la miseria, preludio de mayor incertidumbre. [...

  9. 12 CFR 218.740 - Defined terms relating to the sweep accounts exception from the definition of “broker.”

    Science.gov (United States)

    2010-01-01

    ... securities for sales or sales promotion expenses, for personal service, or for the maintenance of shareholder... investment company's securities for sales or sales promotion expenses, for personal service, or for the....S.C. 78c(a)(4)(B)(v)), the following terms shall have the meaning provided: (a) Deferred sales...

  10. Qualidade da carne de frangos de corte submetidos a dietas suplementadas com crômio, criados em diferentes temperaturas ambientais - DOI: 10.4025/actascianimsci.v29i2.218 Meat quality of broiler chicks submeted the supplemented diets with chromium and reared in differents enviromental temperatures - DOI: 10.4025/actascianimsci.v29i2.218

    Directory of Open Access Journals (Sweden)

    Nívea Maria Brancaci Zeoula

    2007-11-01

    Full Text Available Foram realizados dois experimentos. O experimento um objetivou avaliar a composição da carne do peito de frangos alimentados com dietas suplementadas com crômio (0, 400, 800 e 1.200 μg Cr kg-1 complexado a levedura, criados sob diferentes condições de temperatura (quente, termoneutra e fria. O experimento dois objetivou avaliar a qualidade da carne do peito de frangos alimentados com dietas suplementadas com crômio (0 e 400 μg Cr kg-1, criados nas mesmas condições do experimento um e desossados em diferentes períodos (0, 5 e 24 horas. Os resultados mostram que as aves criadas em ambiente frio apresentaram a carne com menor porcentagem de matéria mineral e crômio e maior intensidade de vermelho, enquanto as aves criadas em temperatura termoneutra apresentaram carne com menor porcentagem de umidade, e as aves criadas em temperatura quente, carne com maior luminosidade. Já a suplementação de crômio não proporcionou qualquer efeito na composição e na qualidade de carne, enquanto que o aumento no período de desossa proporcionou um menor comprimento de sarcômero, força de cisalhamento e intensidade de amarelo, porém uma maior luminosidade.Two experiments were conducted being the objective of the first experiment to evaluate the the composition of breast meat of broiler chicks fed with diets supplemented with chromium yeast (0; 400; 800 and 1,200 μg Cr kg-1 reared in different environmental temperatures (hot, thermoneutral and cold. The second experiment aimed to evaluate the quality of breast meat of broiler chicks fed with diets supplemented with chromium yeast (0 and 400 μg Cr kg-1, reared in different environmental temperatures (hot, thermoneutral and cold and deboned in different periods (0, 5 and 24 hours. The results showed that birds reared in cold environmental temperature showed meat with lower mineral matter percentage and chromium and higher values of redness, whereas the birds reared in thermoneutral environment showed breast meat with lower moistness percentage and the birds reared in hot environmental temperature showed increase values of lightness. The supplementation of chromium presented no effect on the composition and meat quality. Whereas the increase in deboned period provided lower sarcomere length, shear force and yellowness, however higher lightness.

  11. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity...

  12. Successful radioimmunotherapy of established syngeneic rat colon carcinoma with 211At-mAb

    DEFF Research Database (Denmark)

    Eriksson, Sophie E; Bäck, Tom; Elgström, Erika

    2013-01-01

    Most carcinomas are prone to metastasize despite successful treatment of the primary tumor. One way to address this clinical challenge may be targeted therapy with α-emitting radionuclides such as astatine-211 (211At). Radioimmunotherapy utilizing α-particle emitting radionuclides is considered...... colon carcinoma with tumor diameters of approximately 10 mm....

  13. Molecular clouds and star formation toward the Galactic plane within 216.25$^{\\rm o}\\le$ l $\\le$218.75$^{\\rm o}$ and $-$0.75$^{\\rm o} \\le$ b $\\le$1.25$^{\\rm o}$

    CERN Document Server

    Gong, Y; Fang, M; Zhang, S B; Su, Y; Yang, J; Jiang, Z B; Xu, Y; Wang, M; Wang, Y; Lu, D R; Sun, J X

    2016-01-01

    As a part of the Milky Way Imaging Scroll Painting (MWISP) survey, we performed a simultaneous 12CO(1-0), 13CO(1-0), C18O(1-0) mapping toward molecular clouds in a region encompassing 3.75 square degrees. We reveal three molecular clouds, the 15 km/s cloud, the 27 km/s cloud, and the 50 km/s cloud, in the surveyed region. The 50 km/s cloud is resolved with an angular resolution of around 1' for the first time. Investigating their morphology and velocity structures, we find that the 27 km/s cloud is likely affected by feedback from the stellar association Mon OB3 and the 50 km/s cloud is characterised by three large expanding molecular shells. The region is mapped in C18O (1-0) for the first time. We discover seven C18O clumps, which are likely to form massive stars, and 15 dust clumps based on the BGPS archival data. Using infrared color-color diagrams, we find 56 Class I and 107 Class II young stellar object (YSO) candidates. According to the distribution of YSO candidates, an overdensity is found around the...

  14. CTD Data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT218-227 during 2010) (NCEI Accession 0087584)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  15. Information Literacy Programs and Research: Reflections on "Information Literacy Programs and Research: An International Review" by Christine Bruce. 2000. "The Australian Library Journal" 49 no. 3: 209-218.

    Science.gov (United States)

    Bruce, Christine

    2011-01-01

    Although in the late 1990s there was much discussion as to whether the idea of information literacy was necessary or had longevity, global interest in the phenomenon has increased rather than diminished. Information literacy standards have been developed and become widely accepted in educational systems. Research centres for information literacy…

  16. Germán Rodas Chaves. Eloy Alfaro y Cuba en el Siglo XIX. La Habana: Fondo Editorial Casa de las Américas, 2013. 218 páginas.

    OpenAIRE

    René Villaboy Zaldivar

    2015-01-01

    A propósito de que la República del Ecuador fuera el país invitado de honor a la XXIII Feria Internacional del Libro de la Habana, numerosas ediciones relacionadas con la literatura, el arte, la historia, la política y, en general, sobre la rica cultura del país andino vieron la luz en febrero de 2014. A una de ellas dedico este comentario. Se trata de Eloy Alfaro y Cuba en el siglo XIX, del historiador ecuatoriano Germán Rodas Chaves, publicada con excelente factura dentro de la colecc...

  17. Germán Rodas Chaves. Eloy Alfaro y Cuba en el Siglo XIX. La Habana: Fondo Editorial Casa de las Américas, 2013. 218 páginas.

    Directory of Open Access Journals (Sweden)

    René Villaboy Zaldivar

    2015-01-01

    Full Text Available A propósito de que la República del Ecuador fuera el país invitado de honor a la XXIII Feria Internacional del Libro de la Habana, numerosas ediciones relacionadas con la literatura, el arte, la historia, la política y, en general, sobre la rica cultura del país andino vieron la luz en febrero de 2014. A una de ellas dedico este comentario. Se trata de Eloy Alfaro y Cuba en el siglo XIX, del historiador ecuatoriano Germán Rodas Chaves, publicada con excelente factura dentro de la colección investigaciones del Fondo Editorial de la Casa de las Américas.

  18. Subtask 2.18 - Advancing CO2 Capture Technology: Partnership for CO2 Capture (PCO2C) Phase III

    Energy Technology Data Exchange (ETDEWEB)

    Kay, John; Azenkeng, Alexander; Fiala, Nathan; Jensen, Melanie; Laumb, Jason; Leroux, Kerryanne; McCollor, Donald; Stanislowski, Joshua; Tolbert, Scott; Curran, Tyler

    2016-03-31

    Industries and utilities continue to investigate ways to decrease their carbon footprint. Carbon capture and storage (CCS) can enable existing power generation facilities to meet the current national CO2 reduction goals. The Partnership for CO2 Capture Phase III focused on several important research areas in an effort to find ways to decrease the cost of capture across both precombustion and postcombustion platforms. Two flue gas pretreatment technologies for postcombustion capture, an SO2 reduction scrubbing technology from Cansolv Technologies Inc. and the Tri-Mer filtration technology that combines particulate, NOx, and SO2 control, were evaluated on the Energy & Environmental Research Center’s (EERC’s) pilot-scale test system. Pretreating the flue gas should enable more efficient, and therefore less expensive, CO2 capture. Both technologies were found to be effective in pretreating flue gas prior to CO2 capture. Two new postcombustion capture solvents were tested, one from the Korea Carbon Capture and Sequestration R&D Center (KCRC) and one from CO2 Solutions Incorporated. Both of these solvents showed the ability to capture CO2 while requiring less regeneration energy, which would reduce the cost of capture. Hydrogen separation membranes from Commonwealth Scientific and Industrial Research Organisation were evaluated through precombustion testing. They are composed of vanadium alloy, which is less expensive than the palladium alloys that are typically used. Their performance was comparable to that of other membranes that have been tested at the EERC. Aspen Plus® software was used to model the KCRC and CO2 Solutions solvents and found that they would result in significantly improved overall plant performance. The modeling effort also showed that the parasitic steam load at partial capture of 45% is less than half that of 90% overall capture, indicating savings that could be accrued if 90% capture is not required. Modeling of three regional power plants using the Carnegie Mellon Integrated Environmental Control Model showed that, among other things, the use of a bypass during partial capture may minimize the size of the capture tower(s) and result in a slight reduction in the revenue required to operate the capture facility. The results reinforced that a one-size-fits-all approach cannot be taken to adding capture to a power plant. Laboratory testing indicated that Fourier transform infrared spectroscopy could be used to continuously sample stack emissions at CO2 capture facilities to detect and quantify any residual amine or its degradation products, particularly nitrosamines. The information gathered during Phase III is important for utility stakeholders as they determine how to reduce their CO2 emissions in a carbon-constrained world. This subtask was funded through the EERC–U.S. Department of Energy (DOE) Joint Program on Research and Development for Fossil Energy-Related Resources Cooperative Agreement No. DE-FC26-08NT43291. Nonfederal funding was provided by the North Dakota Industrial Commission, PPL Montana, Nebraska Public Power District, Tri-Mer Corporation, Montana–Dakota Utilities Co., Basin Electric Power Cooperative, KCRC/Korean Institute of Energy Research, Cansolv Technologies, and CO2 Solutions, Inc.

  19. Niskin Bottle Data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT218-227 during 2010 (NCEI Accession 0087596)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  20. 利用δ18O信息分析冬小麦对浅埋深地下水的利用%Estimation of Groundwater Use of Winter Wheat Using H218O Signatures; A Preliminary Study

    Institute of Scientific and Technical Information of China (English)

    苑晶晶; 袁国富; 罗毅; 孙晓敏; 张娜

    2009-01-01

    黄河下游引黄灌区地下水埋深通常较浅,冬小麦生长季存在对地下水的利用,论文应用稳定同位素方法研究冬小麦对地下水的利用特征.在中国科学院禹城综合试验站开展实验,通过分析不同灌溉处理条件下土壤水和植物茎水δ18O值之间的关系,应用同位素线性混合模型估算了冬小麦不同生育期对地下水的利用比例.研究结果表明,水的18O信息能很好地揭示冬小麦对不同层次土壤水的利用特征,雨养处理、40%田间持水量处理和现行灌溉制度处理下冬小麦在返青后对地下水的利用分别占其总耗水量的28%、22%和4%左右.研究结果显示适度的灌溉有利于促进作物对不同层次土壤水分的稳定利用,而现行的大田灌溉方式则抑制了作物对地下水资源的利用.

  1. Caries dental en niños de 2-18 años con enfermedades hematooncológicas. Hospital Manuel de Jesús Rivera, Managua, Nicaragua. Febrero- agosto 2011

    OpenAIRE

    Espinoza-Palma, Alicia Samanta

    2012-01-01

    El cáncer infantil cada día es más frecuente, y representa un problema de salud pública debido a la elevada tasa de mortalidad y recurrencia que presentan los pacientes tratados. A pesar de que las terapias antineoplásicas han mejorado sustancialmente en los últimos años. Esta población infantil es susceptible a problemas bucodentales como caries, pérdida dental y gingivitis, condición que se agrava por un efecto secundario al tratamiento antineoplásico. La salud bucal en el paciente oncológi...

  2. Multiple bone metastases detected on 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography in a breast cancer patient: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Zeki Dostbil

    2012-09-01

    Full Text Available Bone scintigraphy has been widely used to assess skeletal metastasis in patients with breast cancer. 18F-FDGPET/CT is another imaging modality that has gained previously wide use to determine metastasis based on increased glucose metabolism in malignant cells. Generally, these two modalities give similar results in evaluation of bone metastasis of breast cancer. In this breast cancer case, 99mTc-MDP bone scintigraphy showed normal findings in regards to skeletal metastasis while 18FFDG-PET/CT, contrast-enhanced CT and MRI revealed multiple metastatic focuses. J Clin Exp Invest 2012; 3 (3: 426-429Key words: 18F-fluorodeoxyglucose, bone metastasis, bone scintigraphy, positron emission tomography

  3. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  4. Sp ectroscopy of Low-lying States in Odd-Z Odd-A Nuclei Beyond Lead

    Institute of Scientific and Technical Information of China (English)

    U Jakobsson; S Juutinen; A Herzan; J Konki; M Leino; M Mallaburn; J Pakarinen; P Papadakis; J Partanen; P Rahkila; M Sandzelius; J Uusitalo; J Saren; C Scholey; J Sorri; S Stolze; K Auranen; H Badran; B Cederwall; D M Cox; T Grahn; P T Greenlees; R Julin

    2016-01-01

    Low-lying states in odd-Z odd-mass nuclei at the proton drip-line beyond lead have recently been studied through fusion-evaporation reactions using a gas-filled recoil separator. Isomeric 1/2+ and 13/2+ states have been observed in odd-mass astatine and francium nuclei. The systematic behaviour of the level energies of these states have been studied and a similarity between the 1/2+ state in astatine and francium has been found. Furthermore, the 13/2+ state has been observed in the francium nuclei with an oblate behaviour suggesting a coupling of the i13/2 proton to the 2p−2h intruder excitation.

  5. Two-component relativistic density-functional calculations of the dimers of the halogens from bromine through element 117 using effective core potential and all-electron methods.

    Science.gov (United States)

    Mitin, Alexander V; van Wüllen, Christoph

    2006-02-14

    A two-component quasirelativistic Hamiltonian based on spin-dependent effective core potentials is used to calculate ionization energies and electron affinities of the heavy halogen atom bromine through the superheavy element 117 (eka-astatine) as well as spectroscopic constants of the homonuclear dimers of these atoms. We describe a two-component Hartree-Fock and density-functional program that treats spin-orbit coupling self-consistently within the orbital optimization procedure. A comparison with results from high-order Douglas-Kroll calculations--for the superheavy systems also with zeroth-order regular approximation and four-component Dirac results--demonstrates the validity of the pseudopotential approximation. The density-functional (but not the Hartree-Fock) results show very satisfactory agreement with theoretical coupled cluster as well as experimental data where available, such that the theoretical results can serve as an estimate for the hitherto unknown properties of astatine, element 117, and their dimers.

  6. Valor pronóstico del análisis semicuantitativo del grado de fijación de la 2.[.[18f]fluoro-2-deoxi-d-glucosa mediante tomografía por emisión de positrones en pacientes pediátricos con linfoma

    OpenAIRE

    Borrego Dorado, Isabel

    2016-01-01

    El linfoma es una neoplasia relativamente frecuente en niños y adolescentes jóvenes constituyendo del 10% al 15% de todas las neoplasias que aparecen durante la edad pediátrica1, 2. Su pronóstico ha mejorado gracias al desarrollo de nuevos tratamientos en las 2 últimas décadas3, presentando un amplio rango de supervivencia global a los 5 años, que varía desde el 75% en los linfoma no hodgkin (LNH) hasta el 90% en la en¬fermedad de Hodgkin (EH)4-6. Por otra parte, la duración e intensidad del ...

  7. Study Fails to Link ILL Usage Patterns to Liaison Activities. A Review of: Leykam, Andrew. “Exploring Interlibrary Loan Usage Patterns and Liaison Activities: The Experience at a U.S. University.” Interlending & Document Supply 36.4 (2008: 218-24.

    Directory of Open Access Journals (Sweden)

    Scott Marsalis

    2009-06-01

    Full Text Available Objective - To investigate Interlibrary Loan (ILL usage patterns, and connect them to liaison activities beyond collection development.Design – Pattern analysis of ILL requests.Setting – Library of The College of Staten Island, a mid-size, public university with predominantly undergraduate enrolment.Subjects – 4,875 identifiable requests over a three-year period.Methods – A data set of requests for ILLs of monographs over a period of three years was acquired from OCLC resource sharing statistics. This data was manually reviewed to remove duplicate records of the same request, but not multiple requests for the same item. The data included requestor status, department, publication date and subject classification of requested items.Main Results – Differences in use across user statuses and departments were identified.Conclusion – Usage Patterns can accurately illustrate trends in the borrowing behaviour of patrons, and be used to inform liaison librarians about user needs.

  8. Dicty_cDB: [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VF (Link to library) VFC218 (Link to dictyBase) - - - Contig-U12091-1 VFC218P (Link... to Original site) VFC218F 487 VFC218Z 391 VFC218P 878 - - Show VFC218 Library VF (Link to library) Clone ID VFC218 (Link to dict...yBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U12091-1 Original site URL http://dict... J03515 |J03515.1 Slime mold (D.discoideum) severin mRNA, complete cds. 856 0.0 3 U66525 |U66525.1 Dictyoste...mic 24.0 %: mitochondrial 20.0 %: nuclear 4.0 %: peroxisomal >> prediction for VF

  9. Alpha-decay studies of the new isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At

    CERN Document Server

    Kettunen, H; Grahn, T; Greenlees, P T; Jones, P; Julin, R; Juutinen, S; Keenan, A; Kuusiniemi, P; Leino, M; Leppaenen, A P; Nieminen, P; Pakarinen, J; Rahkila, P; Uusitalo, J

    2003-01-01

    Detailed alpha-decay studies have been performed for the neutron-deficient isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At. The nuclei were produced in fusion-evaporation reactions of sup 5 sup 4 Fe and sup 5 sup 6 Fe ions with a sup 1 sup 4 sup 1 Pr target. The fusion products were separated in-flight using a gas-filled recoil separator and implanted into a position-sensitive silicon detector. The isotopes were identified using position, time and energy correlations between the implants and subsequent alpha-decays. Three alpha-decaying states were identified for sup 1 sup 9 sup 3 At and two for sup 1 sup 9 sup 1 At. The spin and parity of the initial states in the astatine isotopes were deduced based on unhindered alpha-decays to states in the bismuth daughter nuclei. In both astatine isotopes the 1/2 sup + intruder state was determined to be the ground state and a 7/2 sup - state to be the first-excited state. In sup 1 sup 9 sup 3 At the alpha-decay of the 13/2 sup + state was observed in coincidence...

  10. SU-E-T-96: An Analysis of VMAT SBRT Lung Treatment Plans

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, D; James, J; Wang, B; Dunlap, N; Woo, S; Silverman, C; Dragun, A; El-Ghamry, M [Univ Louisville, Louisville, KY (United States)

    2015-06-15

    Purpose: To present an analysis of 218 lung sbrt treatment plans delivered using Varian Eclipse RapidArc software and delivered with Varian linear accelerators. Methods: A retrospective analysis of treatment plans generated using the Varian Eclipse PRO RapidArc VMAT optimization and AAA photon beam calculation algorithms was done for 218 plans delivered using Varian Trilogy and TrueBeam linear accelerators. Some of the patients were enrolled in the RTOG 0813 and RTOG 0915 lung protocols. All of the patients’ plans were optimized using the guidelines outlined by these protocols. The plans presented were normalized so that 95% of the PTV volume received 100% of the prescribed dose. Results: The dose co formality constraints from the RTOG protocols and the number of plans within those constraints were:Tumor dose between 60% of maximum dose and 90% of maximum: 218/218 = 100%.Volume of 105% tumor dose outside put less than 15% of the PTV volume: 218/218 = 100%.Maximum dose 2 cm away from PTV within protocol table guidelines: No minor deviation: 188/218 = 86.2%. No major deviation: 216/218 = 99.1%.Ratio of 50% dose volume to PTV volume less than R50 in protocol table: No minor deviation 148/218 = 67.9%. No major deviation: 213/218 = 97.7%.Percent of lung receiving 20 Gy less than 10% (no minor violation): 218/218 = 100%.99% of PTV receiving at least 90% of the tumor dose: 214/218 = 98.2%. Conclusion: Varian RapidArc VMAT can successfully deliver lung SBRT treatments as outlined in the RTOG 0813 and 0915 protocols. The largest deviations were seen in the R50 constraints for the larger PTV volumes.

  11. Eesti raamatuajaloo almanahh / Hannes Oja

    Index Scriptorium Estoniae

    Oja, Hannes

    2001-01-01

    rets. rmt. : Raamat on ... : Eesti bibliofiilia ja raamatuajaloo almanahh / Eesti Raamatu Aasta Peakomitee, Tallinna Bibliofiilide Klubi; koost. Eerik Teder. Tallinn : Tallinna Bibliofiilide Klubi, 2000. 218 lk.

  12. Raamat on ... I : Eesti Bibliofiilia ja raamatuajaloo almanahh / Ingrid Paju

    Index Scriptorium Estoniae

    Paju, Ingrid

    2001-01-01

    rets. rmt. : Raamat On ... : Eesti bibliofiilia ja raamatuloo almanahh Eesti Raamatu Aasta Peakomitee, Tallinna Bibliofiilide Klubi; koostaja Eerik Teder. Tallinn : Tallinna Bibliofiilide Klubi, 2000. 218 lk.

  13. Low Response Rate and Other Factors Render Academic Health Science Library System Study Ungeneralizable. A Review of: Folb, B. L., Wessel, C. B., & Czechowski, L. J. (2011. Clinical and academic use of electronic and print books: The Health Sciences Library System e-book study at the University of Pittsburgh. Journal of the Medical Library Association, 99(3, 218-228. doi:10.3163/1536-5050.99.3.009

    Directory of Open Access Journals (Sweden)

    Maria Melssen

    2012-06-01

    Full Text Available Objective – To determine the factors, barriersand facilitators, preference, and intended useof e-book compared to print book usage by allpatrons in a health science library system,which serves a university with health sciencedegree programs and a hospital system.Design – Two online surveys.Setting – University of Pittsburgh HealthSciences Library System, which includes theUniversity of Pittsburgh’s six schools of healthsciences (medicine, dental medicine, nursing,pharmacy, public health, and rehabilitationand the University of Pittsburgh MedicalCenter hospitals and programs.Subjects – All health sciences library systemusrers, including faculty, researchers, clinicians,residents, fellows, employees, and students.Methods – Two versions of the survey weredeployed in 2009 using Opinio. There were 46questions for the University of PittsburghMedical Center (UPMC survey and 47questions for the University of Pittsburgh (Pittsurvey. The surveys were pilot tested byHealth Sciences Library System (HSLSlibrarians and graduate students in a surveymethods class. The survey was edited based onthe feedback provided and receivedinstitutional review board approval as anexempt study.A total of 5,292 email addresses wererandomly selected by SPSS from a pool of 9,472 UPMC and Pitt patrons registered with a HSLS remote access password; 2,684 patrons from UPMC and 2,608 patrons from Pitt were selected. HSLS librarians were excluded from the survey. Participants were emailed a link to the survey in March of 2009. Three email reminders were sent at five day intervals. Data was collected for 22 days and exported from Opinio to SPSS statistics software. Survey results were analyzed using basic descriptive statistics and cross-tabulations.Main Results – Of the 5,292 emails sent, 979 surveys were submitted and 871 were completed fully. The 108 partially completed the surveys were analyzed using pair wise deletion. All HSLS user groups were represented and all rated their confidence in computer skills high. The mean age of respondents was 39.9 with the majority of respondents being female.Of the 871 completed surveys, over half (55.4% of the respondents reported using HSLS e-books: 66.7% men and 54.9% women. HSLS e-books were used for in-depth reading by 53.4% of men and 36.8% of women. At UPMC, 70% of attending physicians, interns, residents, fellows, and Pitt postdoctoral/fellows use HSLS e-books. The primary use of the e-books was for clinical care, by 75.3% of attending physicians; 86% of interns, residents, and fellows; and 38.9% of nurses. HSLS e-books are also used by 61.8% of respiratory care and physical therapists, 28.6% of administrators, and 56.8% of researchers.At Pitt, 73% of postdoctoral students or fellows and 64.7% of faculty used HSLS e-books. The primary use of the e-books was to support research. 76.5% of postdoctoral students and fellows and 54.1% of faculty used e-books for this purpose. Only 21.3% of faculty assigned e-books for class readings. Though 14% of undergraduate and 33.5% of medical students responded that they had been assigned readings from e-books, 51% of undergraduates and 62.1% of graduate and medical students used an e-book to complete an assignment.Over half (65.5% of respondents saw information about HSLS e-books on the HSLS website and 55.4% of respondents used an HSLS e-book. When using an e-book, 56.6% look up brief, factual information while 41.9% use e-books for in-depth study.Uses of HSLS e-book search tools were rated: the federated full text search tool was used by 67.2% of respondents and 74.3% of those who use this tool rated it as moderately to extremely useful. Google books and the library catalog were also rated moderately to extremely useful by respondents. The catalog received the lowest rating of the HSLS e-book search tools.More respondents (95.4% use the library’s website than come to the physical library (63.8%; however, 66.9% say they use both the website and physical library. Of the 63.8% of respondents who came to one of the HSLS libraries, 67.2% borrowed or used a HSLS print book. When using a book at the library, 23.4% only use print, 14.8% only use e-books, 44.7% use both, and 17.1% use neither. Fewer respondents (46.4% agreed or completely agreed they could locate an e-book compared to those who agreed or completely agreed they could locate a print book (66.7%.Nearly half (45.3% agreed that both HSLS e-books and print books were accessible where they needed to use them; however, only 27.9% agreed or completely agreed that they had time to go to the library and use a print book when they needed it. The closer a respondent worked to the library the more likely they used the physical library. Those also within one block of the library were greater users of HSLS e-books (67% of respondents than those who worked more than two blocks from the library (52.3% of respondents. When respondents did come to the library, 84.3% used a HSLS print book in the past year and 64.7% used an HSLS e-book. Of the respondents who did not have time to come to the library, 55.3% used a HSLS print book and 55.3% used a HSLS e-book.When using e-books, respondents preferred such features as printing, saving, and searching over features such as bookmarking, highlighting, and annotating. Respondents also preferred e-books for general reference and pharmaceutical reference, and print books for textbooks and handbooks. A finding of significance is that “those preferring print were more flexible about using e-books than those preferring e-books were about using print” (p. 224.Conclusion – HSLS e-book use varied depending on the respondent’s role at their institution (e.g., clinical physician, researcher and type of book (e.g., reference book they used. The heaviest HSLS e-book users were students, postdoctoral fellows, researchers, and clinical physicians. Respondents who used HSLS e-books most often were also those who used print books most often, and respondents within one block of the library were some of the heaviest HSLS e-book users. Respondents felt that reference and pharmaceutical books were more suitable as e-books. Also of note was that though faculty were not using e-books heavily for assigned readings, students were using HSLS e-books to complete assignments.The greatest drive to choosing between a print and e-book was the respondent’s information need and which book format was most convenient to access at that time. Respondents were flexible in their use of print books and e-books: respondents “would be willing to use a less preferred format if it were more convenient at the time of need” (p.226. In light of respondents’ flexibility between e-book and print book usage, the authors suggest that collection development librarians could reduce the duplication of book formats.Regarding awareness of e-books, survey results from this study were comparable to that of other studies. Also, the respondent’s comments indicate that the survey itself prompted e-book awareness: respondents felt that more advertising of e-books should be done. Such responses show that passive advertisement of e-books though the library’s catalog and on the website are not enough. E-books should be advertised during library instructional sessions.Respondents also prefer Web access to HSLS e-books as well as the HSLS federated e-book search rather than to access HSLS e-books from the library catalog. The authors’ recommendation is to make sure users can easily access e-book catalog records through the Web in order to best facilitate patrons’ use of e-books.Despite the conclusions that were drawn, there were several limitations of this study. Though the sample size was large enough and all HSLS users were included, the response rate was very low. Bias could be an issue as well: non-response bias as well as an overestimation of the number of HSLS e-book users could be contributing factors to the low response rate. In addition to the small sample size and possible bias, the lack of completed responses (11% was also a concern. Finally, respondents expressed confusion over how “e-books” were defined in the survey. Because of these issues, results of this survey may not be generalizable to other libraries.

  14. CAN THE STABILITY OF PROTEIN MUTANTS BE PREDICTED BY FREE-ENERGY CALCULATIONS

    NARCIS (Netherlands)

    YUNYU, S; MARK, AE; WANG, CX; HUANG, FH; BERENDSEN, HJC; VANGUNSTEREN, WF

    1993-01-01

    The use of free energy simulation techniques in the study of protein stability is critically evaluated. Results from two simulations of the thermostability mutation Asn218 to Ser218 in Subtilisin are presented. It is shown that components of the free energy change can be highly sensitive to the comp

  15. Tourism and the coastal zone

    Digital Repository Service at National Institute of Oceanography (India)

    Mascarenhas, A.

    stream_size 1 stream_content_type text/plain stream_name Fish_Curry_Rice_2002_218.pdf.txt stream_source_info Fish_Curry_Rice_2002_218.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  16. Quantum-Limited Image Recognition

    Science.gov (United States)

    1989-12-01

    J. S. Bomba ,’Alpha-numeric character recognition using local operations,’ Fall Joint Comput. Conf., 218-224 (1959). 53. D. Barnea and H. Silverman...for Chapter 6 1. J. S. Bomba ,’Alpha-numeric character recognition using local operations,’ Fall Joint Comput. Conf., 218-224 (1959). 2. D. Bamea and H

  17. Actiniarian Sea anemone fauna of India

    Digital Repository Service at National Institute of Oceanography (India)

    Parulekar, A.H.

    stream_size 11 stream_content_type text/plain stream_name Mar_Biofouling_Power_Plants_1990_218.pdf.txt stream_source_info Mar_Biofouling_Power_Plants_1990_218.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset...

  18. Remote Patient Management in a Mammographic Screening Environment in Underserved Areas

    Science.gov (United States)

    2005-09-01

    of 4,945 paired examinations. Radiology 2001; 218:873-880. 10. Malich A, Marx C, Facius M, Boehm T, Fleck M, Kaiser WA. Tumour 24. Venta LA, Hendrick...218:873-880. KF, Sickles EA. Mammographic character- factor determining the quality of com- 15. Venta LA, Hendrick RE, Adler YT, et al. iSicks of 115

  19. EST Table: FY738861 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY738861 E_FL_famL_06P21_F_0 11/11/04 39 %/218 aa ref|XP_970577.1| PREDICTED: similar to ganglios...006132 11/11/04 n.h 11/11/04 39 %/218 aa gi|91078536|ref|XP_970577.1| PREDICTED: similar to ganglioside-indu

  20. Gclust Server: 201683 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 201683 OSA_@218 Cluster Sequences - 164 no annotation 1 1.00e-80 14.29 0.0 0.0 0.0 0.0 0.0 Show 2016...83 Cluster ID 201683 Sequence ID OSA_@218 Link to cluster sequences Cluster Sequences Link

  1. Is electronegativity a useful descriptor for the pseudo-alkali metal NH4?

    Science.gov (United States)

    Whiteside, Alexander; Xantheas, Sotiris S; Gutowski, Maciej

    2011-11-18

    Molecular ions in the form of "pseudo-atoms" are common structural motifs in chemistry, with properties that are transferrable between different compounds. We have determined one such property--the electronegativity--for the "pseudo-alkali metal" ammonium (NH(4)), and evaluated its reliability as a descriptor versus the electronegativities of the alkali metals. The computed properties of ammonium's binary complexes with astatine and of selected borohydrides confirm the similarity of NH(4) to the alkali metal atoms, although the electronegativity of NH(4) is relatively large in comparison to its cationic radius. We have paid particular attention to the molecular properties of ammonium (angular anisotropy, geometric relaxation and reactivity), which can cause deviations from the behaviour expected of a conceptual "true alkali metal" with this electronegativity. These deviations allow for the discrimination of effects associated with the molecular nature of NH(4).

  2. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

    2013-01-01

    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  3. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: bruce.marsh@cern.ch [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others

    2013-12-15

    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  4. Valproic Acid and Pregnancy

    Science.gov (United States)

    ... Focus on pregnancy (an evidence-based review): II. Teratogenesis and perinatal outcomes: Report of the Quality Standards ... 218. Meador KJ, et al. 2012. Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 ...

  5. Complete Genome Sequence of Xanthomonas arboricola pv. juglandis 417, a Copper-Resistant Strain Isolated from Juglans regia L.

    Science.gov (United States)

    Pereira, Ulisses P; Gouran, Hossein; Nascimento, Rafael; Adaskaveg, James E; Goulart, Luiz Ricardo; Dandekar, Abhaya M

    2015-01-01

    Here, we report the complete genome sequence of Xanthomonas arboricola pv. juglandis 417, a copper-resistant strain isolated from a blighted walnut fruit (Juglans regia L. cv. Chandler). The genome consists of a single chromosome (5,218 kb).

  6. Dicty_cDB: Contig-U09004-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available y: 802 Effective length of database: 97,308,875,965 Effective search space: 78041718523930... Effective search space used: 78041718523930 X1: 11 (21.8 bits) S2: 22 (44.1 bits) protein update 2

  7. WEEKLY WATCH

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    OPINION Popular Majors No More China recently issued its first blue paper on employment. Based on 218,000 valid questionnaires returned by college graduates in 2008, the blue paper says that students majoring in law, IT,

  8. Trapping and Fieldwork Report on the Mammals of Santee National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Introduction and Purpose My 1981 Wofford College Interim Project (independent Project #218) at Santee National Wildlife Refuge was proposed to give me practical f i...

  9. 18 CFR 157.207 - General reporting requirements.

    Science.gov (United States)

    2010-04-01

    ... CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL... specified in § 157.217(b); (g) For each change in customer name authorized under § 157.218, the...

  10. Data of evolutionary structure change: 1ACLA-2C0PB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1ACLA-2C0PB 1ACL 2C0P A B --SELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPV...PMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGC---NDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDG... 0 1ACL AGLU CA 218 LEU CA 292 1ACL A 1ACLA RNLNCNLNSDEEL

  11. Choctaw National Wildlife Refuge Natural Community and Rare Plant Survey

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Choctaw National Wildlife Refuge (CNWR) administers approximately 4,218 acres along theTombigbee River in Choctaw County, Alabama (Figure 1). The Refuge contains a...

  12. Dicty_cDB: Contig-U02167-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 52 1 ( AB031194 ) Ophiocordyceps konnoana mitochondrial gene for sm... 58 0.001 1 ( AF063866 ) Melanoplus sa...e-164 1 ( AU261654 ) Dictyostelium discoideum vegetative cDNA clone:VS... 218 4e-

  13. Keskkonnaministeerium : investeerimine taastuvenergeetikasse on oluline

    Index Scriptorium Estoniae

    2006-01-01

    Keskkonnaministeeriumi andmetel on aastatel 2004-2006 taastuvenergeetikasse kavandatud investeeringuid kokku 218 miljoni krooni ulatuses, mille eest rajatakse nii tuuleparke kui ka hüdroelektrijaamu ning võetakse kasutusele biokütusel köetavaid katlamaju

  14. Läänemere-ruum uurimisainese ja mõistena / Juhan Kreem

    Index Scriptorium Estoniae

    Kreem, Juhan

    2007-01-01

    Rets. rmt.: The Baltic as a Multicultural World : Sea, Region and Peoples. Marko Lehti (ed.). (The Baltic Sea Region : Nordic Dimensions - European Perspectives 4). Berliner Wissenschafts-Verlag, Berlin, 2005. 218 lk.

  15. 77 FR 74006 - Polychlorinated Biphenyls (PCBs); Recycling Plastics From Shredder Residue

    Science.gov (United States)

    2012-12-12

    ...%): 39,000-78,000 tons; other engineering resins, including HIPS (10.9%): 109,000-218,000 tons; polyvinyl...) generally prohibits the manufacture, processing, distribution in commerce and use of PCBs. However, EPA...

  16. Vabaduse Risti vennad - mis on nendest saanud hiljem? / Jaak Pihlak

    Index Scriptorium Estoniae

    Pihlak, Jaak

    2007-01-01

    Teadmata on 218 Vabadusristi kavaleri saatus. Viljandi Muuseumi direktor kutsub üles kõigi Vabadusristi kavaleride saatuse väljaselgitamiseks. Sisaldab teadmata saatusega Vabadusristi kavaleride nimestikku (koost. Mati Strauss ja Jaak Pihlak)

  17. 75 FR 28019 - Resmethrin; Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations

    Science.gov (United States)

    2010-05-19

    ..., recreational, and residential areas to control flying and crawling insects. All remaining resmethrin end use... reproduction 2.1.7 Hershberger (rat) 2.1.8 Female Pubertal (rat) 2.1.9 Male pubertal (rat)...

  18. AcEST: BP918906 [AcEST

    Lifescience Database Archive (English)

    Full Text Available LVKLMDRSGPVIDQLSNEVASETLHACCP 390 Query: 217 LLRQQKYFEICFAWIQQVADLVVS---DGMDFSENVKKELLLSLQE-RVATSMIADSSGT 50...ANELLHTVAH 218 W+ W + ++ DM+SA++EVLST D +LV+LM R+GPV DQL++ A+E LH Sbjct: 331 WTSWTNAMDAFSVGDMDSAFSEVLSTGDDFL

  19. Mineviku varjud / Eerik Purje

    Index Scriptorium Estoniae

    Purje, Eerik, 1927-

    2007-01-01

    rets. rmt.: Soviet deportations in Estonia: impact and legacy : articles and life histories / tlk. Alliki Arro, Madli Puhvel, Lilian Puust; toim. Kristi Kukk, Toivo Raun; eessõna Toivo Raun. Tartu : Tartu Ülikooli Kirjastus, 2007. 218 lk.

  20. Distribution and drug sensitivity of pathogens in diabetic foot ulcer secretions

    Institute of Scientific and Technical Information of China (English)

    李惠琴

    2013-01-01

    Objective To investigate the distribution and drug sensitivity of pathogens isolated from diabetic foot ulcer(DFU) secretions. Methods A retrospective study was carried out on the distribution and drug sensitivity of pathogens isolated from the secretions of 218 DFU

  1. Asthma and American Indians/Alaska Natives

    Science.gov (United States)

    ... Minority Population Profiles > American Indian/Alaska Native > Asthma Asthma and American Indians/Alaska Natives In 2014, 218, ... Native American adults reported that they currently have asthma. American Indian/Alaska Native children are 30% more ...

  2. 77 FR 35424 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Science.gov (United States)

    2012-06-13

    ... review, we cannot guarantee that we will be able to do so. Dated: May 23, 2012. J. Paul Loether, Chief... Company Paper Mill and Sack Factory, 218 Cleveland St., Chagrin Falls, 12000391 Franklin County...

  3. Recruiting Resource and Goal Allocation Decision Model.

    Science.gov (United States)

    1980-01-01

    Number of High Schools AHSS Average High School Size a These variables are available only by flight (i.e., data are not available at the office level...649, 1.96(HSM) . 3 , (INT). I 4 ( AHSS ) - . 9 , (LEAD). 0 4 , (ACO’ 6 9 , (EXP). I I + 5.85(AFB) + 21.8 (3) Where: I. The constant term value 21.8

  4. EA 18G Growler Aircraft (EA 18G)

    Science.gov (United States)

    2015-12-01

    Information Retrieval DoD - Department of Defense DSN - Defense Switched Network EMD - Engineering and Manufacturing Development EVM - Earned Value...Jamming System pods, AN/ALQ- 218 Receiver, Communication Countermeasures Set with functionality equivalent to the USQ-113, and the Multi-Mission Advanced...requirement to conduct LRIP, permit a systematic increase in the production rate of the ALQ- 218 system, and avoid a break in the production line. In LRIP

  5. 77 FR 24228 - Condition Monitoring Techniques for Electric Cables Used in Nuclear Power Plants

    Science.gov (United States)

    2012-04-23

    ...The U.S. Nuclear Regulatory Commission (NRC or the Commission) is issuing a new guide regulatory guide, (RG) 1.218, ``Condition Monitoring Techniques for Electric Cables Used in Nuclear Power Plants.'' This guide describes techniques that the staff of the NRC considers acceptable for condition monitoring of electric cables for nuclear power plants. RG 1.218 is not intended to be prescriptive,......

  6. BWR refill-reflood program: core spray distribution experimental task plan

    Energy Technology Data Exchange (ETDEWEB)

    Eckert, T.

    1981-02-01

    An experimental task plan for the BWR/4 core spray task of the Refill-Reflood Test Program is presented. The test program will provide core spray distribution data for a 30 degree sector of the BWR/4 and 5-218 design. This design uses different nozzle types and different sparger elevations than the BWR/6-218 design which was tested previously. Test parameter ranges are specified; individual tests are defined; and measurement and data utilization plans are defined.

  7. Domain Modeling: NP_001074911.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001074911.1 chr19 EXTRACELLULAR REGION OF THE HUMAN RECEPTOR NKP46 c1p6fa_ chr19/NP_001074911....1/NP_001074911.1_apo_218-419.pdb c1olla_ chr19/NP_001074911.1/NP_001074911.1_holo_218-419.pdb blast 256Y,257K,258E,259G,292Q,293Y,294R,296Y EDO 1 ...

  8. Measurements of the ion fraction and mobility of alpha and beta decay products in liquid xenon using EXO-200

    CERN Document Server

    Albert, J B; Barbeau, P S; Beck, D; Belov, V; Breidenbach, M; Brunner, T; Burenkov, A; Cao, G F; Chambers, C; Cleveland, B; Coon, M; Craycraft, A; Daniels, T; Danilov, M; Daugherty, S J; Davis, C G; Davis, J; Delaquis, S; Der Mesrobian-Kabakian, A; DeVoe, R; Didberidze, T; Dolgolenko, A; Dolinski, M J; Dunford, M; Fairbank, W; Farine, J; Feldmeier, W; Fierlinger, P; Fudenberg, D; Gornea, R; Graham, K; Gratta, G; Hall, C; Hughes, M; Jewell, M J; Jiang, X S; Johnson, A; Johnson, T N; Johnston, S; Karelin, A; Kaufman, L J; Killick, R; Koffas, T; Kravitz, S; Kuchenkov, A; Kumar, K S; Leonard, D S; Licciardi, C; Lin, Y H; Ling, J; MacLellan, R; Marino, M G; Mong, B; Moore, D; Nelson, R; O'Sullivan, K; Odian, A; Ostrovskiy, I; Piepke, A; Pocar, A; Prescott, C Y; Robinson, A; Rowson, P C; Russell, J J; Schubert, A; Sinclair, D; Smith, E; Stekhanov, V; Tarka, M; Tolba, T; Tsang, R; Twelker, K; Vuilleumier, J -L; Waite, A; Walton, J; Walton, T; Weber, M; Wen, L J; Wichoski, U; Wright, J D; Wood, J; Yang, L; Yen, Y -R; Zeldovich, O Ya

    2015-01-01

    Alpha decays in the EXO-200 detector are used to measure the fraction of charged $^{218}\\mathrm{Po}$ and $^{214}\\mathrm{Bi}$ daughters created from alpha and beta decays, respectively. $^{222}\\mathrm{Rn}$ alpha decays in liquid xenon (LXe) are found to produce $^{218}\\mathrm{Po}^{+}$ ions $50.3 \\pm 3.0\\%$ of the time, while the remainder of the $^{218}\\mathrm{Po}$ atoms are neutral. The fraction of $^{214}\\mathrm{Bi}^{+}$ from $^{214}\\mathrm{Pb}$ beta decays in LXe is found to be $76.4 \\pm 5.7\\%$, inferred from the relative rates of $^{218}\\mathrm{Po}$ and $^{214}\\mathrm{Po}$ alpha decays in the LXe. The average velocity of $^{218}\\mathrm{Po}$ ions is observed to decrease for longer drift times. Initially the ions have a mobility of $0.390 \\pm 0.006~\\mathrm{cm}^2/(\\mathrm{kV}~\\mathrm{s})$, and at long drift times the mobility is $0.219 \\pm 0.004~\\mathrm{cm}^2/(\\mathrm{kV}~\\mathrm{s})$. Time constants associated with the change in mobility during drift of the $^{218}\\mathrm{Po}^{+}$ ions are found to be propor...

  9. Analysis of the dry eye syndrome-related factors and outcomes of clinical intervention%眼干燥综合征相关因素分析及临床干预的效果

    Institute of Scientific and Technical Information of China (English)

    张莉莉; 周莉; 徐唐; 周群

    2012-01-01

    目的 探讨眼干燥综合征(干眼症)的相关因素和临床干预效果.方法 干眼症患者218例,随机均分为干预组(A组,常规给予病因治疗、泪液治疗及系统的临床干预)和对照组(B组,仅常规给予病因治疗和泪液治疗),比较两组治疗2周后的泪液功能试验( SIT)、泪膜破裂时间(TBUT)、角膜荧光染色检查(FL)和自我测评等指标.结果 视频终端综合征或看书为干眼症相关的主要因素,占45.41%(99/218),其次分别为闭经或泪腺萎缩老化占37.16%(81/218),眼表手术或用药占33.49%(73/218),户外工作或户外运动者占29.36%(64/218),佩戴隐形眼镜占21.56%(47/218),饮食结构(维生素A缺乏)占7.34%(16/218).A组SIT、TBUT、FL和自我测评评分均明显高于B组(P<0.05).结论 干眼症的相关因素是多方面的,科学、有效的实施临床干预能减轻干眼症患者的症状.%Objective To investigate the dry eye-related factors and the outcomes of clinical intervention. Methods A total of 218 patients with dry eye was randomly divided into two groups of A (given clinical interventions of etiological treatment, tear treatment and the system clinical intervention) and B(treated with etiological treatment and tear treatment only as the control). After treated for two weeks,the Schirmer I test(SIT),tear film break-up time(TBUT),fluorescin staining of cornea(FL) and self-assessment scores were compared between two groups. Results Of the factors related to dry eye syndrome, Vidio end syndrome or reading acounted for 45.41% (99/218), menisschesis and lacrimal atrophy for 37.16%(81/218),surgery or drug administration on the eye surface for 33. 49% (73/218), outdoor working or exercise for 29. 36% (64/218), contact glasses wearing for 21. 56% (47/218), lack of vitamine A for 7. 34% (16/218). The SIT, TBUT, FL and self-assessment scores were all significantly higher in group A than those in group B ( P<0. 05 ) . Conclusion The factors related to

  10. Development of Reagents for Application of At-211 to Targeted Radionuclide Therapy of Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott

    2011-12-23

    This grant covered only a period of 4 months as the major portion of the award was returned to DOE due to an award of funding from NIH that covered the same research objectives. A letter regarding the termination of the research is attached as the last page of the Final Report. The research conducted was limited due to the short period of this grant, but the results obtained in that period are outlined in the Final Report. The studies addressed in the research effort were directed at a problem that is of critical importance to the in vivo application of the alpha-particle emitting radionuclide At-211. That problem, low in vivo stability of many astatinated molecules, severely limits the use of At-211 in therapeutic applications. The advances sought in the studies were expected to expand the types of biomolecules that can be used as carriers of At-211, and provide improved in vivo targeting of the radiation dose compared with the dose delivered to normal tissue.

  11. Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with {sup 211}At-EGF

    Energy Technology Data Exchange (ETDEWEB)

    Sundberg, Aasa Liljegren; Orlova, Anna; Gedda, Lars; Tolmachev, Vladimir; Carlsson, Joergen [Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala (Sweden); Almqvist, Ylva [Division of Radiology, Uppsala University, Uppsala (Sweden); Blomquist, Erik [Division of Oncology, Uppsala University, Uppsala (Sweden); Jensen, Holger J. [Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Rigshospitalet, Copenhagen (Denmark)

    2003-10-01

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib ['Iressa' (trademark of the AstraZeneca group of companies), ZD1839] increases the cellular uptake of radiolabelled epidermal growth factor (EGF). We investigated gefitinib treatment combined with astatine-211 EGF targeting in vitro using two cell lines expressing high levels of EGFR: A431 (sensitive to gefitinib) and U343MGaCl2:1 (resistant to gefitinib). In both cell lines, the uptake of {sup 211}At-EGF was markedly increased by concomitant treatment with gefitinib. Survival was investigated using both a clonogenic survival assay and a cell growth assay. Combined gefitinib and {sup 211}At-EGF treatment reduced the survival of U343 cells 3.5-fold compared with {sup 211}At-EGF alone. In A431 cells, {sup 211}At-EGF treatment resulted in very low survival, but combined treatment with gefitinib increased the survival by about 20-fold. These results indicate that combined treatment with gefitinib might increase the effect of ligand-mediated radionuclide therapy in gefitinib-resistant tumours and decrease the effect of such therapy in gefitinib-sensitive tumours. (orig.)

  12. Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Nestor, Marika, E-mail: marika.nestor@bms.uu.s [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden); Sundstroem, Magnus [Unit of Molecular Pathology, Department of Genetics and Pathology, Uppsala University (Sweden); Anniko, Matti [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Tolmachev, Vladimir [Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden)

    2011-01-15

    Aim: The monoclonal antibody cetuximab, targeting the epidermal growth factor receptor (EGFR), is a promising molecular targeting agent to be used in combination with radiation for anticancer therapy. In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed. Methods: SCC cell lines were characterized and treated with cetuximab in combination with anti-CD44v6 RIT using the astatinated chimeric monoclonal antibody U36 ({sup 211}At-cMAb U36). Effects on {sup 211}At-cMAb U36 uptake, internalization and cell proliferation were then assessed in SCC cells. Results: Cetuximab in combination with {sup 211}At-cMAb U36 mediated increased growth inhibition compared to RIT or cetuximab alone in two cell lines. However, cetuximab also mediated radioprotective effects compared to RIT alone in two cell lines. The radioprotective effects occurred in the cell lines in which cetuximab clearly inhibited cell growth during radiation exposure. Cetuximab treatment also influenced {sup 211}At-cMAb-U36 uptake and internalization, suggesting interactions between CD44v6 and EGFR. Conclusions: Results from this study demonstrate the vast importance of further clarifying the mechanisms of cetuximab and radiation response, and the relationship between EGFR and suitable RIT targets. This is important not only in order to avoid potential radioprotective effects, but also in order to find and utilize potential synergistic effects from these combinations.

  13. Cyclotron production of cesium radionuclides as analogues for francium-221 biodistribution

    Science.gov (United States)

    Finn, R.; McDevitt, M.; Sheh, Y.; Lom, C.; Qiao, J.; Cai, S.; Burnazi, E.; Nacca, A.; Pillarsetty, N.; Jaggi, J.; Scheinberg, D.

    2005-12-01

    In our clinical investigations focussing on improved therapeutic treatment of specific tumors we have concentrated on a targeted therapy approach utilizing designed radiolabeled monoclonal antibodies as the cytotoxic reagent. The physical characteristics of the alpha particle emitting radionuclide bismuth-213 including the short half-life of 45.6 min, has shown promise for the treatment of specific cancers such as leukemias and lymphomas or micrometastatic carcinomas. In an effort to increase the cytocidal effect of the HuM195, a humanized monoclonal antibody carrier to the CD33 antigen expressed on leukemia cells, our focus is directed toward an "internal" nano-generator composed of Ac-225 radionuclide, the parent of the bismuth-213. The actinium-225 radionuclide decays through several short-lived, alpha emitting daughters including francium-221, astatine-217 and bismuth-213. In order to study the biodistribution and the pharmacokinetics of the individual daughter nuclide, francium-221, the cyclotron production and separation of cesium radionuclides, specifically cesium-132, from a natural xenon gas target was undertaken. The choice of cesium as an analogue for francium was predicated upon both elements being in Group 1A alkali metals and cesium radionuclide possesses a sufficient half-life to allow biodistribution studies to be performed. The preliminary experimental results of this investigation are presented.

  14. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  15. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  16. Metalloids, soil chemistry and the environment.

    Science.gov (United States)

    Lombi, Enzo; Holm, Peter E

    2010-01-01

    This chapter reviews physical chemical properties, origin and use ofmetalloids and their relevance in the environment. The elements boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), tellurium (Te), polonium (Po) and astatine (At) are considered metalloids. Metalloids conduct heat and electricity intermediate between nonmetals and metals and they generally form oxides. The natural abundance ofmetalloids varies from Si being the second most common element in the Earth's crust to At as the rarest of natural elements on Earth. The metalloid elements Ge, Te, Po and At are normally present in trace or ultratrace levels in the environment and as such are not considered of relevance in terms of environmental health. The environmental geochemical processes, factors and parameters controlling the partitioning and the speciation of B, Si, As and Sb are reviewed in relation to the bioavailability of these metalloids. Approaches based on the hypothesis that metal toxicity is related to both the metal-ligand complexation processes and the metal interactions with competing cations at the cell surface (biotic ligand) have so far not been successful for assessing metalloid bioavailability. The chapter concludes that our understanding of metalloids toxicity will improve in the future if, in addition to the points discussed above, surface membrane potentials are considered. This should represent a robust approach to the prediction of metalloid toxicity.

  17. SPECT assay of radiolabeled monoclonal antibodies. Progress report, September 1, 1992--August 24, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1993-08-20

    The overall goal of this project is to improve the effectiveness of single photon emission computed tomography (SPECT) to image and quantify radiolabeled monoclonal antibodies. During the past year, we have made significant progress toward this goal, and this report summarizes that work. Our efforts have been mainly directed along three fronts. First, we have developed and tested new reconstruction methods including three-dimensional iterative algorithms that model non-uniform attenuation and distance-dependent detector response. Both fan beam and parallel beam collimator geometries have been modeled and novel ways of improving the efficiency of the computationally intensive methods have been introduced. Second, an ultra-high resolution, small field-of-view pinhole collimator has been constructed and evaluated. Reconstructed spatial resolution of 1 to 3 mm (FWHM) has been achieved in phantom scans with a useful field-of-view of 9 to 10 cm. Finally, we have investigated the ability of SPECT to image and quantify astatine-211 distributions. Reconstructed images of phantom data demonstrated quantitative accuracy to within 10% with proper attenuation and scatter compensation.

  18. Glomerular filtration rate after alpha-radioimmunotherapy with 211At-MX35-F(ab')2: a long-term study of renal function in nude mice

    DEFF Research Database (Denmark)

    Back, T.; Haraldsson, B.; Hultborn, R;

    2009-01-01

    and animals bearing subcutaneous xenografts of the human ovarian cancer cell line, OVCAR-3, were used. The animals received approximately 0.4, 0.8, or 1.2 MBq in one, two, or three fractions. The mean absorbed doses to the kidneys ranged from 1.5 to 15 Gy. The renal function was studied by serial GFR...... of the glomerular filtration rate (GFR). The renal toxicity was evaluated at levels close to the dose limit for the bone marrow and well within the range for therapeutic efficacy on tumors. Astatinated MX35-F(ab')(2) monoclonal antibodies were administered intravenously to nude mice. Both non-tumor-bearing animals...... manifested late. Examination of the kidney sections showed histologic changes that were overall subdued. Following alpha-RIT with (211)At-MX35-F(ab')(2) at levels close to the dose limit of severe myelotoxicity, the effects found on renal function were relatively small, with only minor to moderate reductions...

  19. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  20. Studies of Stable Octupole Deformations in the Radium Region

    CERN Multimedia

    2002-01-01

    The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

  1. Alpha particle emitters in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, D.R.

    1989-09-01

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ({sup 211}At) and natural bismuth-212 ({sup 212}Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ({sup 223}Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

  2. Cyclic nucleotide dependent dephosphorylation of regulator of G-protein signaling 18 in human platelets.

    LENUS (Irish Health Repository)

    Gegenbauer, Kristina

    2013-11-01

    Regulator of G-protein signaling 18 (RGS18) is a GTPase-activating protein that turns off Gq signaling in platelets. RGS18 is regulated by binding to the adaptor protein 14-3-3 via phosphorylated serine residues S49 and S218 on RGS18. In this study we confirm that thrombin, thromboxane A2, or ADP stimulate the interaction of RGS18 and 14-3-3 by increasing the phosphorylation of S49. Cyclic AMP- and cyclic GMP-dependent kinases (PKA, PKG) inhibit the interaction of RGS18 and 14-3-3 by phosphorylating S216. To understand the effect of S216 phosphorylation we studied the phosphorylation kinetics of S49, S216, and S218 using Phos-tag gels and phosphorylation site-specific antibodies in transfected cells and in platelets. Cyclic nucleotide-induced detachment of 14-3-3 from RGS18 coincides initially with double phosphorylation of S216 and S218. This is followed by dephosphorylation of S49 and S218. Dephosphorylation of S49 and S218 might be mediated by protein phosphatase 1 (PP1) which is linked to RGS18 by the regulatory subunit PPP1R9B (spinophilin). We conclude that PKA and PKG induced S216 phosphorylation triggers the dephosphorylation of the 14-3-3 binding sites of RGS18 in platelets.

  3. The Atacama Cosmology Telescope: cross correlation with Planck maps

    Energy Technology Data Exchange (ETDEWEB)

    Louis, Thibaut; Calabrese, Erminia; Dunkley, Joanna; Næss, Sigurd [Department of Astrophysics, Oxford University, Oxford OX1 3RH (United Kingdom); Addison, Graeme E.; Hincks, Adam D. [Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z4 (Canada); Hasselfield, Matthew; Hlozek, Renée [Department of Astrophysical Sciences, Peyton Hall, Princeton University, Princeton, NJ 08544 (United States); Bond, J. Richard; Hajian, Amir [Canadian Institute for Theoretical Astrophysics, University of Toronto, Toronto, ON M5S 3H8 (Canada); Das, Sudeep [Argonne National Laboratory, 9700 S. Cass Ave., Lemont, IL 60439 (United States); Devlin, Mark J. [Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, U.S.A (United States); Dünner, Rolando; Infante, Leopoldo [Departamento de Astronomía y Astrofísica, Facultad de Física, Pontificia Universidad Católica de Chile, Casilla 306, Santiago 22 (Chile); Gralla, Megan; Marriage, Tobias A. [Dept. of Physics and Astronomy, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218-2686 (United States); Huffenberger, Kevin [Department of Physics, Florida State University, Keen Physics Building, 77 Chieftan Way, Tallahassee, Florida (United States); Kosowsky, Arthur [Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA, 15260 (United States); Moodley, Kavilan [Astrophysics and Cosmology Research Unit, School of Mathematical Sciences, University of KwaZulu-Natal, Durban, 4041 (South Africa); Niemack, Michael D., E-mail: Thibaut.Louis@astro.ox.ac.uk [Joseph Henry Laboratories of Physics, Jadwin Hall, Princeton University, Princeton, NJ 08544 (United States); and others

    2014-07-01

    We present the temperature power spectrum of the Cosmic Microwave Background obtained by cross-correlating maps from the Atacama Cosmology Telescope (ACT) at 148 and 218 GHz with maps from the Planck satellite at 143 and 217 GHz, in two overlapping regions covering 592 square degrees. We find excellent agreement between the two datasets at both frequencies, quantified using the variance of the residuals between the ACT power spectra and the ACT × Planck cross-spectra. We use these cross-correlations to measure the calibration of the ACT data at 148 and 218 GHz relative to Planck, to 0.7% and 2% precision respectively. We find no evidence for anisotropy in the calibration parameter. We compare the Planck 353 GHz power spectrum with the measured amplitudes of dust and cosmic infrared background (CIB) of ACT data at 148 and 218 GHz. We also compare planet and point source measurements from the two experiments.

  4. The Atacama Cosmology Telescope: Cross Correlation with Planck maps

    CERN Document Server

    Louis, Thibaut; Hasselfield, Matthew; Bond, J Richard; Calabrese, Erminia; Das, Sudeep; Devlin, Mark J; Dunkley, Joanna; Dünner, Rolando; Gralla, Megan; Hajian, Amir; Hincks, Adam D; Hlozek, Renée; Huffenberger, Kevin; Infante, Leopoldo; Kosowsky, Arthur; Marriage, Tobias A; Moodley, Kavilan; Næss, Sigurd; Niemack, Michael D; Nolta, Michael R; Page, Lyman A; Partridge, Bruce; Sehgal, Neelima; Sievers, Jonathan L; Spergel, David N; Staggs, Suzanne T; Walter, Benjamin Z; Wollack, Edward J

    2014-01-01

    We present the temperature power spectrum of the Cosmic Microwave Background obtained by cross-correlating maps from the Atacama Cosmology Telescope (ACT) at 148 and 218 GHz with maps from the Planck satellite at 143 and 217 GHz, in two overlapping regions covering 592 square degrees. We find excellent agreement between the two datasets at both frequencies, quantified using the variance of the residuals between the ACT power spectra and the ACTxPlanck cross-spectra. We use these cross-correlations to calibrate the ACT data at 148 and 218 GHz, to 0.7% and 2% precision respectively. We find no evidence for anisotropy in the calibration parameter. We compare the Planck 353 GHz power spectrum with the measured amplitudes of dust and cosmic infrared background (CIB) of ACT data at 148 and 218 GHz. We also compare planet and point source measurements from the two experiments.

  5. Core-level X-ray photoemission spectral shift through the successive phase transitions in layered TlInS{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Ishizu, Takahiko [Department of Mathematical Sciences, Graduate School of Engineering, Osaka Prefecture University, Sakai 599-8531 (Japan); Mimura, Kojiro [Department of Mathematical Sciences, Graduate School of Engineering, Osaka Prefecture University, Sakai 599-8531 (Japan)], E-mail: mimura@ms.osakafu-u.ac.jp; Shim, Yong Gu [Department of Physics and Electronics, Graduate School of Engineering, Osaka Prefecture University, Sakai 599-8531 (Japan); Wakita, Kazuki [Department of Electrical, Electronics and Computer Engineering, Chiba Institute of Technology, Narashino 275-0016 (Japan); Mamedov, Nazim [Institute of Physics, Azerbaijan National Academy of Science, Baku, AZ-1143 (Azerbaijan); Taguchi, Yukihiro; Ichikawa, Kouichi [Department of Mathematical Sciences, Graduate School of Engineering, Osaka Prefecture University, Sakai 599-8531 (Japan)

    2008-12-31

    Temperature-dependent change in core-level electronic structures of the layered semiconductor-ferroelectric TlInS{sub 2} with incommensurate phase has been investigated by means of X-ray photoemission spectroscopy. The temperature dependence of the relative peak position for each core level (Tl 4f, In 3d and S 2p) is found to differ very much in the regions bordering each other at the normal-incommensurate phase transition point of 218 K. The obtained data suggest that the charge distribution in TlInS{sub 2} dramatically changes upon passing from the normal phase (T > 218 K) to the spatially modulated incommensurate phase (T < 218 K)

  6. Combined 18F-Fluoride and 18F-FDG PET/CT Scanning for Evaluation of Malignancy: Results of an International Multicenter Trial

    DEFF Research Database (Denmark)

    Iagaru, Andrei; Mittra, Erik; Mosci, Camila;

    2012-01-01

    -FDG PET/CT. The 3 PET/CT scans were performed sequentially within 4 wk of one another for each patient. Results: 18F2/18FFDG PET/CT allowed for accurate interpretation of radiotracer uptake outside the skeleton, with findings similar to those of 18F-FDG PET/CT. In 19 participants, skeletal disease...... was more extensive on 18F2 PET/CT and 18F2/18F-FDG PET/CT than on 18F-FDG PET/CT. In another 29 participants, 18F2 PET/CT and 18F2/18F-FDG PET/CT showed osseous metastases where 18FFDG PET/CT was negative. The extent of skeletal lesions was similar in 18 participants on all 3 scans. Conclusion: This trial...

  7. 18O labeling of chlorophyll d in Acaryochloris marina reveals that chlorophyll a and molecular oxygen are precursors.

    Science.gov (United States)

    Schliep, Martin; Crossett, Ben; Willows, Robert D; Chen, Min

    2010-09-10

    The cyanobacterium Acaryochloris marina was cultured in the presence of either H(2)(18)O or (18)O(2), and the newly synthesized chlorophylls (Chl a and Chl d) were isolated using high performance liquid chromatography and analyzed by mass spectroscopy. In the presence of H(2)(18)O, newly synthesized Chl a and d, both incorporated up to four isotopic (18)O atoms. Time course H(2)(18)O labeling experiments showed incorporation of isotopic (18)O atoms originating from H(2)(18)O into Chl a, with over 90% of Chl a (18)O-labeled at 48 h. The incorporation of isotopic (18)O atoms into Chl d upon incubation in H(2)(18)O was slower compared with Chl a with approximately 50% (18)O-labeled Chl d at 115 h. The rapid turnover of newly synthesized Chl a suggested that Chl a is the direct biosynthetic precursor of Chl d. In the presence of (18)O(2) gas, one isotopic (18)O atom was incorporated into Chl a with approximately the same kinetic incorporation rate observed in the H(2)(18)O labeling experiment, reaching over 90% labeling intensity at 48 h. The incorporation of two isotopic (18)O atoms derived from molecular oxygen ((18)O(2)) was observed in the extracted Chl d, and the percentage of double isotopic (18)O-labeled Chl d increased in parallel with the decrease of non-isotopic-labeled Chl d. This clearly indicated that the oxygen atom in the C3(1)-formyl group of Chl d is derived from dioxygen via an oxygenase-type reaction mechanism.

  8. 18O Labeling of Chlorophyll d in Acaryochloris marina Reveals That Chlorophyll a and Molecular Oxygen Are Precursors*

    Science.gov (United States)

    Schliep, Martin; Crossett, Ben; Willows, Robert D.; Chen, Min

    2010-01-01

    The cyanobacterium Acaryochloris marina was cultured in the presence of either H218O or 18O2, and the newly synthesized chlorophylls (Chl a and Chl d) were isolated using high performance liquid chromatography and analyzed by mass spectroscopy. In the presence of H218O, newly synthesized Chl a and d, both incorporated up to four isotopic 18O atoms. Time course H218O labeling experiments showed incorporation of isotopic 18O atoms originating from H218O into Chl a, with over 90% of Chl a 18O-labeled at 48 h. The incorporation of isotopic 18O atoms into Chl d upon incubation in H218O was slower compared with Chl a with ∼50% 18O-labeled Chl d at 115 h. The rapid turnover of newly synthesized Chl a suggested that Chl a is the direct biosynthetic precursor of Chl d. In the presence of 18O2 gas, one isotopic 18O atom was incorporated into Chl a with approximately the same kinetic incorporation rate observed in the H218O labeling experiment, reaching over 90% labeling intensity at 48 h. The incorporation of two isotopic 18O atoms derived from molecular oxygen (18O2) was observed in the extracted Chl d, and the percentage of double isotopic 18O-labeled Chl d increased in parallel with the decrease of non-isotopic-labeled Chl d. This clearly indicated that the oxygen atom in the C31-formyl group of Chl d is derived from dioxygen via an oxygenase-type reaction mechanism. PMID:20610399

  9. Kinetics of electron recombination of dye-sensitized solar cells based on TiO2 nanorod arrays sensitized with different dyes.

    Science.gov (United States)

    Wang, Hongxia; Liu, Meinan; Zhang, Min; Wang, Peng; Miura, Hidetoshi; Cheng, Yan; Bell, John

    2011-10-14

    The performance and electron recombination kinetics of dye-sensitized solar cells based on TiO(2) films consisting of one-dimensional nanorod arrays (NR-DSSCs) which are sensitized with dyes N719, C218 and D205, respectively, have been studied. It has been found that the best efficiency is obtained with the dye C218 based NR-DSSCs, benefiting from a 40% higher short-circuit photocurrent density. However, the open circuit photovoltage of the N719 based cell is 40 mV higher than that of the organic dye C218 and D205 based devices. Investigation of the electron recombination kinetics of the NR-DSSCs has revealed that the effective electron lifetime, τ(n), of the different dye based NR-DSSCs shows the sequence of C218 > D205 > N719. The higher V(oc) with the N719 based NR-DSSC is originated from the more negative energy level of the conduction band of the TiO(2) film. In addition, in comparison to the DSSCs with the conventional nanocrystalline particles based TiO(2) films, the NR-DSSCs have shown over two orders of magnitude higher τ(n) when employing N719 as the sensitizer. Nevertheless, the τ(n) of the DSSCs with the C218 based nanorod arrays is only ten-fold higher than that of the nanoparticles based devices. The remarkable characteristic of the dye C218 in suppressing the electron recombination of DSSCs is discussed.

  10. Special Inspector General for Iraq Reconstruction Quarterly Report to the United States Congress

    Science.gov (United States)

    2012-04-30

    Iraq Freedom Fund (TFBSO) Nonproliferation, Anti-terrorism, Demining, and Related Programs (NADR)f Department of Justice (DoJ) 37 2 11 Child ...INL, INL/ ACCO is currently staff ed by an unspecifi ed num- ber of U.S. offi cials, one bilingual cultural advisor, and one translator.154 used to...wife, child , and brother killed Tribal sheik • 2/18 Gunman attack on home Killed; son wounded Criminal judge • 2/18 Gunman attack on home Killed

  11. Selected Design Parameters for Reclining Seats Based on Engineering Anthropometry

    Science.gov (United States)

    1977-09-01

    Height 21.8 0.92 Not available Sitting Cervicale Height 25.5 0.86 Not available Sitting Knee Height 21.8 0.83 21.97 0.94 * All linear dimensions in...proper targets were affixed on these landmarks. *A horizontal line at the level of the spinous process of T-4 (4th thoracic vertebra ) was drawn on the... vertebra at upright seated position. Point #13 is the body point of contact with the subject’s back and the back rest. T-4 mark t Tý) 1- 419-- 0 t si g

  12. Uma colaboradora que lhe corresponda?

    Directory of Open Access Journals (Sweden)

    Dellazari, Romano

    2007-01-01

    Full Text Available Este estudo quer verificar na lingua portuguesa, a tradução do sintoma hebraico 'ezer kenegedô (Gn 2,18. 20, traduzido pela Biblia de Jerusalém como "uma auxiliar que lhe corresponda" (Gn 2,18 e "a auxiliar que lhe correspondesse". (Gn 2,20 é a melhor tradução ou se é possível propor uma tradução que condiz mais com o contexto, como p. ex. um(a colaboradora(a que lhe corresponda

  13. Herschel/HIFI spectroscopy of the intermediate mass protostar NGC 7129 FIRS 2

    DEFF Research Database (Denmark)

    Johnstone, D.; Fich, M.; McCoey, C.

    2010-01-01

    Herschel/HIFI observations of water from the intermediate mass protostar NGC 7129 FIRS 2 provide a powerful diagnostic of the physical conditions in this star formation environment. Six spectral settings, covering four H216O and two H218O lines, were observed and all but one H218O line were...... are consistent with emission from water arising in the envelope around the intermediate mass protostar, and the abundance of H2O is constrained to ˜10-7 for the outer envelope. Additionally, the presence of a narrow self-absorption component for the lowest energy lines is likely due to self-absorption from...

  14. Gclust Server: 96142 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 96142 Glv_gvip218=narB Cluster Sequences Related Sequences(208) 692 nitrate reducta...se 1 1.00e-35 0.0 0.0 4.0 0.0 0.0 0.0 Show 96142 Cluster ID 96142 Sequence ID Glv_gvip218=narB Link to cluster sequences Clus...tative annotation nitrate reductase Number of Sequences 1 Homologs 1 Clustering t...r of Sequences for each species Glv: 1 Species not appearing in this cluster ATH: 0 OSA: 0 PoTR: 0 PPT: 0 CR

  15. Mupirocin for the reduction of colonization of internal jugular cannulae: a randomized controlled trial

    NARCIS (Netherlands)

    R.L.R. Hill; A. P. Fisher; R. J. Ware; S. Wilson; M. W. Casewell

    1990-01-01

    textabstractIn a prospective study, 218 cardiothoracic patients, in whom 'Abbocath-T' cannulae had been inserted preoperatively into the internal jugular vein, were randomized to receive skin preparation of the insertion site with tincture of iodine (108 controls) or tincture of iodine followed by a

  16. The genome of melon (Cucumis melo L.). Genome amplification in the absence of recent duplication in an old widely cultivated species

    Science.gov (United States)

    We report the genome sequence of melon (Cucumis melo L.), an important horticultural crop worldwide. We assembled 375 Mb of the double haploid line DHL92, representing 83.3 % of the estimated melon genome. We predicted 27,427 protein-coding genes, which we analyzed by reconstructing 22,218 phylogene...

  17. 47 CFR 95.851 - Certification.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Certification. 95.851 Section 95.851 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES 218-219 MHz Service Technical Standards § 95.851 Certification. Each CTS and RTU transmitter...

  18. 78 FR 69369 - Laminated Woven Sacks From the People's Republic of China: Final Results of the Expedited Sunset...

    Science.gov (United States)

    2013-11-19

    ... method either to an exterior ply of plastic film such as biaxially-oriented polypropylene (BOPP) or to an...'s Republic of China: Countervailing Duty Order, 73 FR 45955 (August 7, 2008). \\2\\ See Initiation of Five-Year (``Sunset'') Reviews, 78 FR 39256 (July 1, 2013). 19 CFR 351.218 (e)(1)(ii)(A) states...

  19. 18.CONNECTIVE TISSUE DISORDER

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930734 Measurement of serum soluble interleukin—2 receptor in connective tissue diseases.CAI Houronget al.Dept Intern Med,Affili Gulou Hosp,Med School,Nanjing Univ,Nanjing,210008,ShanghaiJ Immunol 1993;13(4):216—218December 1993 Vol 10 No 4

  20. 76 FR 17965 - In the Matter of Certain Mobile Telephones and Wireless Communication Devices Featuring Digital...

    Science.gov (United States)

    2011-03-31

    ... COMMISSION In the Matter of Certain Mobile Telephones and Wireless Communication Devices Featuring Digital... States after importation of certain mobile telephones and wireless communication devices featuring digital cameras, and components thereof, that infringe certain claims of U.S. Patent No. 6,292,218...

  1. 77 FR 43858 - Certain Mobile Telephones and Wireless Communication Devices Featuring Digital Cameras, and...

    Science.gov (United States)

    2012-07-26

    ... COMMISSION Certain Mobile Telephones and Wireless Communication Devices Featuring Digital Cameras, and... States after importation of certain mobile telephones and wireless communication devices featuring digital cameras, and components thereof, that infringe certain claims of U.S. Patent No. 6,292,218...

  2. Domain Modeling: NP_085116.2 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_085116.2 chr5 Solution structure of the tandem four zf-C2H2 domain repeats of mu...rine GLI-Kruppel family member HKR3 c2dlqa_ chr5/NP_085116.2/NP_085116.2_holo_209-322.pdb blast 216C,218E,21

  3. 78 FR 50091 - Notice of Intent To Repatriate Cultural Items: University of Colorado Museum of Natural History...

    Science.gov (United States)

    2013-08-16

    ... Shannon, Curator of Cultural Anthropology, University of Colorado Museum of Natural History, 218 UCB... Museum of Natural History have determined that: Pursuant to 25 U.S.C. 3001(3)(C), the five cultural items... National Park Service Notice of Intent To Repatriate Cultural Items: University of Colorado Museum...

  4. Characterization of marine bacteria highly resistant to mercury exhibiting multiple resistances to toxic chemicals

    Digital Repository Service at National Institute of Oceanography (India)

    De, J.; Ramaiah, N.

    of subjective complaints in a population living in a methylmercury-polluted area. Environ. Res. 81, pp. 100-107. 10. Gerlach, A.S., 1981. Marine Pollution. Diagnosis and Therapy. Springer-Verlag Berlin Heidelberg New York. pp. 218. 11. Hideomi, N...

  5. African-American Parents' Racial and Ethnic Socialization and Adolescent Academic Grades: Teasing out the Role of Gender

    Science.gov (United States)

    Brown, Tiffany L.; Linver, Miriam R.; Evans, Melanie; DeGennaro, Donna

    2009-01-01

    This study examined the relationship of racial and ethnic socialization and academic achievement in a sample of 218 African American adolescents (grades 9-12; 52% girls) attending a public high school in the northeastern United States. Researchers were particularly interested in whether adolescent gender moderated the relationship between racial…

  6. The Ro 15-1788 cue: Evidence for benzodiazepine agonist and inverse agonist properties

    NARCIS (Netherlands)

    Vry, J. De; Slangen, J.L.

    1985-01-01

    Rats discriminating Ro 15–1788 (10 mg/kg, i.p.) from vehicle completely generalized this cue to typical benzodizepines, and partially generalized it to barbiturates, pentylenetetrazol, CGS 8216, β-CCM and PK 8165. CL 218 872, Ro 5–4864, phenytoine, progabide, propranolol, yohimbine and various CNS s

  7. Yeast Extract: Sucrose Ratio Effects on Egg Load, Survival, and Mortality Caused by GF-120 in Western Cherry Fruit Fly

    Science.gov (United States)

    Extrinsic sources of nitrogen are needed by tephritid fruit flies for optimal nutrition. In this study, relationships between yeast extract diets containing 0, 0.109, 0.545, 1.09, 2.18, 3.27, and 5.45% nitrogen (N) and diet intake, survival, egg production, and responses to spinosad bait in western...

  8. AcEST: BP917978 [AcEST

    Lifescience Database Archive (English)

    Full Text Available IC6|VGLG_LNYV Glycoprotein G OS=Lettuce necrotic yellows v... 29 9.4 sp|A6VMF8|MEND_ACTSZ 2-succinyl-5-enolp...SPQKVVIENSWAFRNGINY 259 Query: 218 WKD 210 W D Sbjct: 260 WND 262 >sp|Q9DIC6|VGLG_LNYV Glycoprotein G OS=Lettuce

  9. The Analysis of Organizational Diagnosis on Based Six Box Model in Universities

    Science.gov (United States)

    Hamid, Rahimi; Siadat, Sayyed Ali; Reza, Hoveida; Arash, Shahin; Ali, Nasrabadi Hasan; Azizollah, Arbabisarjou

    2011-01-01

    Purpose: The analysis of organizational diagnosis on based six box model at universities. Research method: Research method was descriptive-survey. Statistical population consisted of 1544 faculty members of universities which through random strafed sampling method 218 persons were chosen as the sample. Research Instrument were organizational…

  10. 41 CFR 102-75.725 - What does the transfer request contain?

    Science.gov (United States)

    2010-07-01

    ... DISPOSAL Surplus Real Property Disposal Property for Displaced Persons § 102-75.725 What does the transfer... property is required to house displaced persons authorized by section 218; that all other options... obtain replacement housing for displaced persons as authorized under title II of the Relocation Act;...

  11. Validity and reproducibility of motion sensors in youth: A systematic update

    NARCIS (Netherlands)

    Vries, S.I. de; Hirtum, H.W.J.E.M. van; Bakker, I.; Hopman-Rock, M.; Hirasing, R.A.; Mechelen, W. van

    2009-01-01

    Purpose: To review recently published studies on the reproducibility, validity, and feasibility of motion sensors used to assess physical activity in healthy children and adolescents (2-18 yr). Methods: On October 2004, a systematic literature search in PubMed, EMBASE, and PsycINFO was performed. Th

  12. Exploring Physical Activity by Ethnicity and Gender in College Students Using Social Cognitive Theory

    Science.gov (United States)

    Nehl, Eric J.; Blanchard, Chris M.; Kupperman, Janet; Sparling, Phillip; Rhodes, Ryan; Torabi, Mohammad R.; Courneya, Kerry S.

    2012-01-01

    Intervention;The psychological determinants of physical activity (PA) among college students may vary by ethnicity and gender, but few studies have considered these characteristics. This study tested constructs from Social Cognitive Theory (SCT) by ethnicity and gender to explain differences in PA. A total of 231 Blacks (70% female) and 218 White…

  13. Recognizing filamentous basidiomycetes as agents of human disease: A review

    NARCIS (Netherlands)

    Chowdhary, A.; Kathuria, S.; Agarwal, K.; Meis, J.F.G.M.

    2014-01-01

    Filamentous basidiomycetes (BM) are common environmental fungi that have recently emerged as important human pathogens, inciting a wide array of clinical manifestations that include allergic and invasive diseases. We reviewed 218 reported global cases of BM fungi. The most common etiologic agent was

  14. Urokinase-Type Plasminogen Activator Receptor as a Potential PET Biomarker in Glioblastoma

    DEFF Research Database (Denmark)

    Persson, Morten; Nedergaard, Mette K; Brandt-Larsen, Malene

    2016-01-01

    an orthotopic xenograft model of glioblastoma. Tumor growth was monitored using bioluminescence imaging. Five to six weeks after inoculation, all mice were scanned with small-animal PET/CT using two new uPAR PET ligands ((64)Cu-NOTA-AE105 and (68)Ga-NOTA-AE105) and, for comparison, O-(2-(18)F...

  15. Serial Multiple Mediation of General Belongingness and Life Satisfaction in the Relationship between Attachment and Loneliness in Adolescents

    Science.gov (United States)

    Yildiz, Mehmet Ali

    2016-01-01

    The current research aims to investigate the serial-multiple mediation of general belongingness and life satisfaction in the relationship between loneliness and attachment to parents and peers in adolescents. The participants of the research consisted of 218 high school students (F = 126, 57.8%; M = 92, 42.2%). Age of the participants' ranged…

  16. Eluruumi kvaliteedi mittevastavus lepingutingimustele müüja ja kinnisvaramaakleri vastutuse alusena : [magistritöö] / Monika Pihlak ; Tartu Ülikool, õigusteaduskond ; juhendaja: Irene Kull

    Index Scriptorium Estoniae

    Pihlak, Monika, 1990-

    2015-01-01

    Kinnisasjadele eluruumidena esitatavatest nõuetest, ostja teadmisest või teadma pidamisest asja mittevastavusest, müüja teavitamiskohustusest, VÕS § 218 lg 1 kui vastutusstandardist ja rikkumisele tuginemisest, maakleri teavitamiskohustusest ja selle rikkumise tagajärgedest

  17. 75 FR 52528 - Mandatory Reliability Standards for the Bulk-Power System; Notice of Technical Conference

    Science.gov (United States)

    2010-08-26

    ... Energy Regulatory Commission Mandatory Reliability Standards for the Bulk-Power System; Notice of... ] 61,053 (2007). \\2\\ Mandatory Reliability Standards for the Bulk Power System, 130 FERC ] 61,218... a frequency response requirement.'' \\3\\ \\1\\ Mandatory Reliability Standards for the...

  18. 77 FR 45490 - Safety Zone, Barrel Recovery, Lake Superior; Duluth, MN

    Science.gov (United States)

    2012-08-01

    ... Avenue SE., Washington, DC 20590, between 9 a.m. and 5 p.m., Monday through Friday, except Federal... Judson Coleman, Chief of Waterways Management, U.S. Coast Guard Marine Safety Unit Duluth; telephone number (218) 720- 5286, extension 111, email at Judson.A.Coleman@uscg.mil . If you have questions...

  19. An Examination of the Impact of Racial and Ethnic Identity, Impostor Feelings, and Minority Status Stress on the Mental Health of Black College Students

    Science.gov (United States)

    McClain, Shannon; Beasley, Samuel T.; Jones, Bianca; Awosogba, Olufunke; Jackson, Stacey; Cokley, Kevin

    2016-01-01

    This study examined ethnic identity, racial centrality, minority status stress, and impostor feelings as predictors of mental health in a sample of 218 Black college students. Ethnic identity was found to be a significant positive predictor of mental health, whereas minority status stress and impostor feelings were significant negative predictors.…

  20. SwissProt search result: AK060335 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK060335 001-008-C02 (Q9Z218) Dipeptidyl aminopeptidase-like protein 6 (Dipeptidylpeptidase VI) (Dipeptidy...lpeptidase 6) (Dipeptidyl peptidase IV-like protein) (Dipeptidyl aminopeptidase-related protein) (DPPX) DPP6_MOUSE 7e-29 ...

  1. SwissProt search result: AK110189 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK110189 002-162-A04 (Q9Z218) Dipeptidyl aminopeptidase-like protein 6 (Dipeptidylpeptidase VI) (Dipeptidy...lpeptidase 6) (Dipeptidyl peptidase IV-like protein) (Dipeptidyl aminopeptidase-related protein) (DPPX) DPP6_MOUSE 1e-52 ...

  2. SwissProt search result: AK100736 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK100736 J023118B01 (Q9Z218) Dipeptidyl aminopeptidase-like protein 6 (Dipeptidylpeptidase VI) (Dipeptidy...lpeptidase 6) (Dipeptidyl peptidase IV-like protein) (Dipeptidyl aminopeptidase-related protein) (DPPX) DPP6_MOUSE 6e-43 ...

  3. Investigation of Pre-Service Teachers' Communication Skills

    Science.gov (United States)

    Kana, Fatih

    2015-01-01

    The purpose of this study is to determine the levels of Turkish language pre-service teachers' communication skills. Descriptive survey model was used in this study. 218 pre-service Turkish language teachers, who are studying at Department of Turkish Language Teaching at a university in the west of Turkey, participated in the study. Criterion…

  4. Exploring Writing Anxiety and Self-Efficacy among EFL Graduate Students in Taiwan

    Science.gov (United States)

    Ho, Mei-ching

    2016-01-01

    This study investigates research writing anxiety and self-efficacy beliefs among English-as-a-Foreign-Language (EFL) graduate students in engineering-related fields. The relationship between the two writing affective constructs was examined and students' perspectives on research writing anxiety were also explored. A total of 218 survey responses…

  5. Odontocete Movements off the Island of Kauai: Results of Satellite Tagging and Photo-Identification Efforts in January 2012

    Science.gov (United States)

    2012-08-27

    structure of island-associated dolphins: evidence from mitochondrial and microsatellite markers for common bottlenose dolphins (Tursiops truncatus... malfunction . The Pacific Missile Range Facility (PMRF) boundary is shown. 7    21.8 21.9 22 22.1 22.2 -160 -159.9 -159.8 -159.7 -159.6 -159.5 La tit

  6. 10 CFR 20.1003 - Definitions.

    Science.gov (United States)

    2010-01-01

    .... Working level (WL) is any combination of short-lived radon daughters (for radon-222: polonium-218, lead-214, bismuth-214, and polonium-214; and for radon-220: polonium-216, lead-212, bismuth-212, and... radioactive material, including radon (except as a decay product of source or special nuclear material);...

  7. Cerebral glucose metabolism in long-term survivors of childhood primary brain tumors treated with surgery and radiotherapy

    DEFF Research Database (Denmark)

    Andersen, Preben B.; Krabbe, Katja; Leffers, Anne M.

    2003-01-01

    a median recurrence free survival of 16 years by MRI and Positron Emission Tomography using the glucose analog 2-18F-fluoro-2-deoxy-D-glucose (18FDG). Three patients were not analyzed further due to diffuse cerebral atrophy, which might be related to previous hydrocephalus. Twenty-one patients were...

  8. The Validity of Project Assessment in an Advanced Level Biology Examination.

    Science.gov (United States)

    Brown, C. R.; And Others

    1995-01-01

    Assessment of practical objectives by means of a project which occurred in an operational Advanced level examination in the United Kingdom is analyzed for construct validity. As in previous research, low correlation were found between scores of (n=218) candidates on the project and on the other components of the examination. (18 references)…

  9. Drug: D03343 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 8 (JP16); MDS (TN) Therapeutic category: 2189 ATC code: B05AA05 map07052 Antidyslipidemic agents Therapeutic... category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 21 Cardiovascular agents 218 Hyperlipidemia agents

  10. Drug: D04269 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available saponifiable matter of soybean oil. map07052 Antidyslipidemic agents Therapeutic category of drugs in Japan ...[BR:br08301] 2 Agents affecting individual organs 21 Cardiovascular agents 218 Hyperlipidemia agents 2189 Others D04269 Soysterol (JAN) PubChem: 47206204 ...

  11. Romantic Relationship Commitment and Its Linkages with Commitment to Parents and Friends during Adolescence

    Science.gov (United States)

    De Goede, Irene H. A.; Branje, Susan; van Duin, Jet; VanderValk, Inge E.; Meeus, Wim

    2012-01-01

    This five-wave longitudinal study examines linkages between adolescents' perceptions of romantic relationship commitment and the development of adolescents' perceptions of commitment to parents and friends. A total of 218 early-to-middle adolescents (39.0 percent boys) and 185 middle-to-late adolescents (30.8 percent boys) participated.…

  12. Profiles of Racial Socialization among African American Parents: Correlates, Context, and Outcome

    Science.gov (United States)

    Caughy, Margaret O'Brien; Nettles, Saundra Murray; Lima, Julie

    2011-01-01

    Self report and observational data on racial socialization practices in a sample of 218 African American parents of young children were used to determine whether or not parents could be characterized in terms of their pattern of racial socialization practices. Parents fell into four groups: silence about race, emphasis on cultural socialization,…

  13. How European American and Taiwanese Mothers Talk to Their Children about Learning

    Science.gov (United States)

    Li, Jin; Fung, Heidi; Bakeman, Roger; Rae, Katharine; Wei, Wanchun

    2014-01-01

    Little cross-cultural research exists on parental socialization of children's learning beliefs. The current study compared 218 conversations between European American and Taiwanese mothers and children (6-10 years) about good and poor learning. The findings support well-documented cultural differences in learning beliefs. European Americans…

  14. 78 FR 33152 - Agency Information Collection Activities; Information Collection Renewal; Submission for OMB...

    Science.gov (United States)

    2013-06-03

    ..., Office of the Comptroller of the Currency, Attention: 1557-0219, 400 7th Street SW., Suite 3E-218, Mail... requirements that members of the public submit reports, keep records, or provide information to a third party... techniques or other forms of information technology; and (e) Estimates of capital or start-up costs and...

  15. 78 FR 60376 - Agency Information Collection Activities; Information Collection Renewal; Submission for OMB...

    Science.gov (United States)

    2013-10-01

    ... Currency, Attention: 1557-0246, 400 7th Street SW., Suite 3E-218, Mail Stop 9W-11,Washington, DC 20219. In... that members of the public submit reports, keep records, or provide information to a third party. With... collection techniques or other forms of information technology; and (e) Estimates of capital or start...

  16. Warm water deuterium fractionation in IRAS 16293-2422 - The high-resolution ALMA and SMA view

    CERN Document Server

    Persson, Magnus V; van Dishoeck, Ewine F

    2012-01-01

    Measuring the water deuterium fractionation in the inner warm regions of low-mass protostars has so far been hampered by poor angular resolution obtainable with single-dish ground- and space-based telescopes. Observations of water isotopologues using (sub)millimeter wavelength interferometers have the potential to shed light on this matter. Observations toward IRAS 16293-2422 of the 5(3,2)-4(4,1) transition of H2-18O at 692.07914 GHz from Atacama Large Millimeter/submillimeter Array (ALMA) as well as the 3(1,3)-2(2,0) of H2-18O at 203.40752 GHz and the 3(1,2)-2(2,1) transition of HDO at 225.89672 GHz from the Submillimeter Array (SMA) are presented. The 692 GHz H2-18O line is seen toward both components of the binary protostar. Toward one of the components, "source B", the line is seen in absorption toward the continuum, slightly red-shifted from the systemic velocity, whereas emission is seen off-source at the systemic velocity. Toward the other component, "source A", the two HDO and H2-18O lines are detecte...

  17. 76 FR 50268 - Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance

    Science.gov (United States)

    2011-08-12

    ... Reporting to Armonk, NY TA-W-73,218A International Business Machines Corporation, Web Strategy and... Armonk, NY. In accordance with Section 223 of the Trade Act of 1974, as amended (``Act''), 19 U.S.C. 2273... various states in the United States reporting to Armonk, New York. The workers are engaged in...

  18. Intergenerational Transmission of Internalizing Problems: Effects of Parental and Grandparental Major Depressive Disorder on Child Behavior

    Science.gov (United States)

    Pettit, Jeremy W.; Olino, Thomas M.; Roberts, Robert E.; Seeley, John R.; Lewinsohn, Peter M.

    2008-01-01

    Effects of lifetime histories of grandparental (G1) and parental (G2) major depressive disorder (MDD) on children's (G3) internalizing problems were investigated among 267 G3 children (ages 2-18 years) who received Child Behavior Checklist (CBCL) ratings and had diagnostic data available on 267 biological G2 parents and 527 biological G1…

  19. Continuous Hyperfractionated Accelerated Radiation Therapy In Head And Neck Cancers- A Pilot Study

    Directory of Open Access Journals (Sweden)

    Thejaswini B

    2014-09-01

    Conclusion:CHART achieves good locoregional response in stages III and IV of head and neck cancer. The acute mucosal reactions were within acceptable limits. The compliance to the treatment was good. [Natl J Med Res 2014; 4(3.000: 218-221

  20. 40 CFR 147.2400 - State-administered program-Class I, II, III, IV, and V wells.

    Science.gov (United States)

    2010-07-01

    ... (Bureau of National Affairs, 1983 Laws), entitled “Oil and Gas Conservation”; (5) Revised Code of... (Bureau of National Affairs, 1983 Laws); (2) Washington Administrative Code sections 173-218-010 to 173...) Other laws. The following statutes and regulations although not incorporated by reference, also are...

  1. High frequency microphone measurements for transition detection on airfoils

    DEFF Research Database (Denmark)

    Døssing, Mads

    pressure) and Tollmien-Schlichting frequencies. The tests were made at Reynolds and Mach numbers corresponding to the operating conditions of a typical horizontal axis wind turbine (HAWT). The Risø B1-18, Risø C2-18 and NACA0015 profiles were tested and the measured transition points are reported....

  2. 76 FR 59125 - Environmental Impacts Statements; Notice of Availability

    Science.gov (United States)

    2011-09-23

    ..., Don Edwards San Francisco Bay National Wildlife Refuge, Bair Island State Ecological Reserve, South... National Forest, Eastern Region, Cook County, MN, Review Period Ends: 10/24/2011, Contact: Peter Taylor 218-626-4368. EIS No. 20110316, Draft EIS, USACE, CA, Pier S Marine Terminal Development and Back...

  3. Effect of Lures and Trap Placement on Sand Fly and Mosquito Traps

    Science.gov (United States)

    2008-01-01

    Phlebotomus guggisbergi, a vector of Leishmania tropica in Kenya. Med. Vet. Entomol. 7:216-218. Killick-Kendrick, R. 1999. The biology and control...Acta Tropica 101:106-114. Hoel, D.E, Butler, J.F., Fawaz, E.Y., Watany, N., El-Hossary, S.S., and Villinski, J. 2007. Response of phlebotomine sand

  4. How accurately do maize crop models simulate the interactions of atmospheric CO2 concentration levels with limited water supply on water use and yield?

    Science.gov (United States)

    This study assesses the ability of 21 crop models to capture the impact of elevated CO2 concentration ([CO218 ]) on maize yield and water use as measured in a 2-year Free Air Carbon dioxide Enrichment experiment conducted at the Thünen Institute in Braunschweig, Germany (Manderscheid et al. 2014). D...

  5. Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors

    DEFF Research Database (Denmark)

    Clausen, Malene M.; Hansen, Anders Elias; af Rosenschold, Per Munck;

    2013-01-01

    Introduction: Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy...

  6. Blunt Head Trauma and Headache

    Directory of Open Access Journals (Sweden)

    Ana B Chelse

    2015-04-01

    Full Text Available Investigators from New York Presbyterian Morgan Stanley Children’s Hospital examined whether having an isolated headache following minor blunt head trauma was suggestive of traumatic brain injury (TBI among a large cohort of children 2-18 years of age.

  7. 47 CFR 95.859 - Antennas.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Antennas. 95.859 Section 95.859... SERVICES 218-219 MHz Service Technical Standards § 95.859 Antennas. (a) The overall height from ground to topmost tip of the CTS antenna shall not exceed the height necessary to assure adequate service....

  8. 42 CFR 57.205 - Health professions student loan funds.

    Science.gov (United States)

    2010-10-01

    ... FOR CONSTRUCTION OF TEACHING FACILITIES, EDUCATIONAL IMPROVEMENTS, SCHOLARSHIPS AND STUDENT LOANS... will be accounted for separately from other funds, providing a clear audit trail for all transactions... noncompliance provisions of § 57.218 and the Department's Claims Collections regulations (45 CFR part 30),...

  9. 76 FR 9047 - Ridgefield National Wildlife Refuge, Clark County, WA; Final Comprehensive Conservation Plan and...

    Science.gov (United States)

    2011-02-16

    ... waterfowl. The Refuge encompasses 5,218 acres of marshes, grasslands, and woodlands on 5 units. We preserve... and wet meadow acreage. Wetlands would be managed to increase productivity and reduce water pumping... would complete habitat assessments to guide stream and tidally influenced wetland restorations. We...

  10. Domain Modeling: NP_001561.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001561.3 chr3 Structural Basis for the Interaction of TAK1 Kinase with its Activ...ating Protein TAB1 p2evaa_ chr3/NP_001561.3/NP_001561.3_holo_194-543.pdb psi-blast 216I,217S,218Q,219G,224V,

  11. Materialism, Sociocultural Appearance Messages, and Paternal Attitudes Predict College Women's Attitudes about Cosmetic Surgery

    Science.gov (United States)

    Henderson-King, Donna; Brooks, Kelly D.

    2009-01-01

    Rates of cosmetic surgery procedures have increased dramatically over the past several decades, but only recently have studies of cosmetic surgery attitudes among the general population begun to appear in the literature. The vast majority of those who undergo cosmetic surgery are women. We examined cosmetic surgery attitudes among 218

  12. We Want You: It Takes a Village To Market the Army

    Science.gov (United States)

    2013-03-01

    corporate/Pages/default.aspx (accessed December 20, 2012). 84 Ibid. 85 Philip Kotler and Nancy Lee, Corporate Social Responsibility: Doing the Most...18. 92 Ibid., 18. 93 Head, 4. 94 Kotler and Lee, 239. 95 Ibid., 209. 96 Ibid., 218. 97 U.S. Army Marketing and Research Group, “Army

  13. Quantification of Kryptofix2.2.2 in ~(18)FDG by HPLC

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    2-deoxy-2-[18F] fluoro-D-glucose (18FDG) is the most commonly used radiopharmaceutical for positron emission tomography (PET). Kryptofix2.2.2 (K-222) is used as a phase-transfer catalyst in the synthesis of 18FDG.Because of its toxicity

  14. Do Children Understand the Basic Relationship Between Speech and Writing? The Mow-Motorcycle Test.

    Science.gov (United States)

    Rozin, Paul; And Others

    School children (N=218) who have not yet attained moderate reading fluency were tested for their awareness of a fundamental relationship between our writing system and speech: that the sounds of speech are represented in writing. Children were shown a long and short word written on a card (e.g., mow and motorcycle), and asked which word…

  15. Mexican American Fathers' Occupational Conditions: Links to Family Members' Psychological Adjustment

    Science.gov (United States)

    Crouter, Ann C.; Davis, Kelly D.; Updegraff, Kimberly; Delgado, Melissa; Fortner, Melissa

    2006-01-01

    To examine the implications of fathers' occupational conditions (i.e., income, work hours, shift work, pressure, workplace racism, and underemployment) for family members' psychological adjustment, home interviews were conducted with fathers, mothers, and two adolescent offspring in each of 218 Mexican American families. Results underscored the…

  16. Study on the Microwave Permittivity of Single-Walled Carbon Nanotube

    Science.gov (United States)

    Liu, Xiaolai; Zhao, Donglin

    2009-01-01

    In this article, we studied the microwave permittivity of the complex of the single-walled carbon nanotube and paraffin in 2-18GHz. In the range, the dielectric loss of single-walled carbon nanotube is higher, and the real part and the imaginary part of the dielectric constant decrease with the increase of frequency, and the dielectric constant…

  17. A Laser Feedback Control Design for Passive Ring Laser Gyros in a Very High Finesse Cavity.

    Science.gov (United States)

    1985-12-01

    14 II. Theory ....................... 16 Optical Cavities ................ 16 Laser Fundamentals ...............24 The Gaussian Beam. ...............28...c 1-(ABC 1h(.8 = (2.18) F = 1 2.19) - (RARCRD) t = = (2.20) C c[i- (RARRc%)] Laser Fundamentals A laser consists of three basic components: a gain

  18. Total synthesis and evaluation of [18F]MHMZ

    DEFF Research Database (Denmark)

    Herth, Matthias M; Debus, Fabian; Piel, Markus;

    2008-01-01

    Radiochemical labeling of MDL 105725 using the secondary labeling precursor 2-[(18)F]fluoroethyltosylate ([(18)F]FETos) was carried out in yields of approximately 90% synthesizing [(18)F]MHMZ in a specific activity of approximately 50MBq/nmol with a starting activity of approximately 3GBq. Overal...

  19. A Study of Strategic Lessons Learned in Vietnam. Volume 6. Conduct of the War. Book 2. Functional Analyses

    Science.gov (United States)

    1980-05-02

    Repaired 77 5) Wells Constructed by US/FWMAF 387 Repaired 218joint w/RVNAF 389 Repaired 36 SOURCE: MACV Command Histo 1067, Volume II. Figurae 14-3. Civic... Publica - tions, Inc. 1972. Corson, William R. The Betrayal. New York: W. W. Norton & Co., 1968. Corson, William R. Consequences of Failure. New York

  20. 18 CFR 1304.2 - Application.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Application. 1304.2 Section 1304.2 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY APPROVAL OF...) 386-2228, Reservoirs: Pickwick, Bear Creek; (8) Suite 218, Heritage Federal Bank Building, 4105...

  1. Torvald Køhls Observatorium

    DEFF Research Database (Denmark)

    Bock, Lars Nicolai; Hyllestad, Nikolaj

    2002-01-01

    .218 tilhørere fordelt på 1823 foredrag. Hans private observationer blev publiceret i førende tyske og amerikanske tidsskrifter. Køhl var inspirator for mange mennesker - bl.a for Møller Nikolajsen, der senere kom til at lave vigtige udgravninger af Tycho Brahes Uranienborg på Hven. Hans private observatorium er...

  2. 75 FR 81565 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Science.gov (United States)

    2010-12-28

    ...... Huzhou Gu's Import & Export Co., Ltd Jiangsu Fengtai Diamond Tool Manufacture Co., Ltd Jiangsu Fengyu... Shengkang Foodstuff Co., Ltd CMEC Engineering Machinery Import & Export Co., Ltd Dongying Shunyifa Chemical... under 19 CFR 351.211 or a determination under 19 CFR 351.218(f)(4) to continue an order or...

  3. F-35 Joint Strike Fighter: Preliminary Observations on Program Progress

    Science.gov (United States)

    2016-03-23

    inefficiencies and requiring workarounds. Engine manufacturing deliveries remain steady and 218 engines have been delivered to date. The labor hours...contractors that build the F-35 airframes and engines continue to report improved manufacturing efficiency and supply chain performance. The F-35...program’s (1) future modernization (2) affordability, remaining development, and ongoing manufacturing plans. GAO analyzed program documentation

  4. [Pertti Virtaranta. Lyydiläisiä tekstejä VI. Anna Vasiljevna Ţesnakovan kerrontaa ja itkuvirsiä] / Paul Alvre

    Index Scriptorium Estoniae

    Alvre, Paul

    1995-01-01

    Arvustus: Pertti Virtaranta. Lyydiläisiä tekstejä VI. Anna Vasiljevna Ţesnakovan kerrontaa ja itkuvirsiä. Suomalais-Ugrilaisen Seuran Toimituksia 218. Helsinki, 1994. 256 s.; Näytteitä karjalan kielestä I. Karjalan Tasavallan ja Sisä-Venäjän karjalaismurteet. Joensuu-Petroskoi, 1994

  5. Dihhotomia / Aksel Tamm ; zapissala Ljudmila Glushkovskaja

    Index Scriptorium Estoniae

    Tamm, Aksel, 1931-

    1996-01-01

    Intervjuu kauaaegse 'Eesti Raamatu' peatoimetajaga nõukogude kirjastamis- ja tõlkepoliitikast ning tsensuurist. Ka Mihhail Bulgakovi romaani 'Meister ja Margarita' tõlkimisest eesti keelde ja avaldamisest (1968). Veaparandus: [Glushkovskaja, Ljudmila]. kotshetovka-kretshetovka-kotshetovka. // Võshgorod (1997) nr. 1-2, lk. 218

  6. 77 FR 9859 - Lifesaving Equipment: Production Testing and Harmonization With International Standards

    Science.gov (United States)

    2012-02-21

    ... Regulations and Standards Directorate, Office of Design and Engineering Standards, Lifesaving and Fire Safety... resolutions MSC.207(81), MSC.218(82), and MSC.272(85)), and the Recommendation on Testing (as amended up... impacts in the SNPRM. We have identified three U.S.-owned entities involved in the manufacture of...

  7. 76 FR 17825 - Initiation of Antidumping Duty Administrative Reviews, Requests for Revocation in Part, and...

    Science.gov (United States)

    2011-03-31

    ... Works, Ltd. Meltroll Engineering Pvt. Ltd. Mukand, Ltd. Sindia Steels Limited Snowdrop Trading Pvt. Ltd...., Ltd. ] Xuzhou Carbon Co., Ltd. Xuzhou Electrode Factory Xuzhou Jianglong Carbon Manufacture Co., Ltd... duty order under 19 CFR 351.211 or a determination under 19 CFR 351.218(f)(4) to continue an order...

  8. Registri järgi on Lääne-Virumaal 3012 ühingut ja ettevõtet

    Index Scriptorium Estoniae

    2005-01-01

    Justiitsministeeriumi andmeil oli Lääne-Virumaal 2005. a. alguses registrisse kantud 218 aktsiaseltsi, 1668 osaühingut, 34 tulundusühingut ja 9 täisühingut, 110 usaldusühingut, samuti 958 mittetulundusühingut ja 15 sihtasutust

  9. 76 FR 82268 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Science.gov (United States)

    2011-12-30

    ... America, Inc. Huzhou Gu's Import & Export Co., Ltd. Jiangsu Fengtai Diamond Tool Manufacture Co., Ltd... Shengkang Foodstuff Co., Ltd. CMEC Engineering Machinery Import & Export Co,. Ltd. Dongying Shunyifa....218(f)(4) to continue an order or suspended investigation (after sunset review), the Secretary,...

  10. Soome ja Karjala uurijate suurtööd : kaks uut tekstikogumikku / Jaan Õispuu

    Index Scriptorium Estoniae

    Õispuu, Jaan

    1996-01-01

    Arvustus: Virtaranta, Pertti. Lyydiläisiä tekstejä. 6, Anna Vassiljevna Tsesnakovan kerrontaa ja itkuvirsiä. Helsinki : Suomalais-ugrilainen seura, 1994. (Suomalais-ugrilaisen Seuran toimituksia ; 218) ; Näytteitä karjalan kielestä. 1, Karjalan Tasavallan ja sisä-venäjän karjalaismurteet. Joensuu ; Petroskoi, 1994

  11. 78 FR 79392 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Science.gov (United States)

    2013-12-30

    ...., Ltd. HXF Saw Co., Ltd. Jiangsu Fengtai Diamond Tool Manufacture Co., Ltd. ] Jiangsu Fengyu Tools Co... Co., Ltd. CMEC Engineering Machinery Import & Export Co., Ltd. Dalian New Century Food Co., Ltd... CFR 351.218(f)(4) to continue an order or suspended investigation (after sunset review), the...

  12. 75 FR 17402 - South Carolina Public Service Authority; Notice of Applications for Amendment of License and...

    Science.gov (United States)

    2010-04-06

    ... following five changes in project land classification: Thornley Subdivision in Berkeley County (-218... commercial lease area; Dingle Pond Area in Berkeley County (-221), 3.4 acres from ``Forest Management'' to ``USFWS'' to correct a ] classification error; and Cross Area in Berkeley County (-222), approximately...

  13. Predicting dropout from intensive outpatient cognitive behavioural therapy for binge eating disorder using pre-treatment characteristics: A naturalistic study

    NARCIS (Netherlands)

    Vroling, M.S.; Wiersma, F.E.; Lammers, M.W.; Noorthoorn, E.O.

    2016-01-01

    Background: Dropout rates in binge eating disorder (BED) treatment are high (17-30%), and predictors of dropout are unknown. Method: Participants were 376 patients following an intensive outpatient cognitive behavioural therapy programme for BED, 82 of whom (21.8%) dropped out of treatment. An explo

  14. The Social and Recreational Characteristics of Adults with Intellectual Disability and Pica Living in Institutions

    Science.gov (United States)

    Ashworth, Melody; Hirdes, John P.; Martin, Lynn

    2009-01-01

    This paper reports on the social life of adults with intellectual disability (ID) who engage in pica behaviour (i.e., ingestion of non-food items). Secondary analyses were conducted on the population of adults residing in Ontario's three remaining specialized institutions for persons with ID (N = 1008); 220 individuals (21.8%) had pica. All…

  15. 76 FR 10560 - Marine Mammals; File No. 15530

    Science.gov (United States)

    2011-02-25

    ... National Oceanic and Atmospheric Administration RIN 0648-XA160 Marine Mammals; File No. 15530 AGENCY... Research, 218 W. 4th Avenue, Olympia, WA 98501, has applied in due form for a permit to take marine mammals... under the authority of the Marine Mammal Protection Act of 1972, as amended (MMPA; 16 U.S.C. 1361 et...

  16. 77 FR 60107 - Marine Mammals; File No. 17298

    Science.gov (United States)

    2012-10-02

    ... National Oceanic and Atmospheric Administration RIN 0648-XC218 Marine Mammals; File No. 17298 AGENCY..., Connecticut 06355 , has applied in due form for a permit to collect, import, export, and receive marine mammal... requested under the authority of the Marine Mammal Protection Act of 1972, as amended (MMPA; 16 U.S.C....

  17. 76 FR 48146 - Marine Mammals; File No. 15330

    Science.gov (United States)

    2011-08-08

    ... National Oceanic and Atmospheric Administration RIN 0648-XA160 Marine Mammals; File No. 15330 AGENCY... Robin Baird, PhD, Cascadia Research, 218\\1/2\\ W. 4th Avenue, Olympia, WA 98501 to take marine mammals in... applicant. The requested permit has been issued under the authority of the Marine Mammal Protection Act...

  18. 77 FR 44069 - Grider Drug #1 & Grider Drug #2; Decision and Order

    Science.gov (United States)

    2012-07-26

    ... 1304.11(c); (8) `` n accountability audit of 50 controlled substances covering period of May 31, 2003... this proceeding. ALJ at 91 & n.46 (citing Ky. Rev. Stat. Sec. 218A.202(8); Sangster v. Kentucky Bd. of... supported by substantial evidence.\\12\\ \\12\\ The Government also introduced data from the DEA ARCOS system...

  19. Data of evolutionary structure change: 1DFFA-3CPMA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1DFFA-3CPMA 1DFF 3CPM A A -----SVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDM...line> 3CPM A 3CPMA THR CA 218 GLY CA 249 ILE CA 245 3CPM... A 3CPMA IKKYSDKLVPFILE CA 305 ARG CA 316 GLN CA 241 3CPM

  20. Data of evolutionary structure change: 1BS5A-3CPMA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1BS5A-3CPMA 1BS5 3CPM A A -----SVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDM...line> 3CPM A 3CPMA THR CA 218 GLY CA 252 ILE CA 234 3CPM... A 3CPMA IKKYSDKLVPFILE CA 320 ARG CA 317 GLN CA 243 3CPM

  1. Structural Equation Models of Management and Decision-Making Styles with Job Satisfaction of Academic Staff in Malaysian Research University

    Science.gov (United States)

    Amzat, Ismail Hussein; Idris, Datuk Abdul Rahman

    2012-01-01

    Purpose: The purpose of this paper is to discuss the effect of management and decision-making styles on the job satisfaction of academic staff in a Malaysian Research University. Design/methodology/approach: The sample consisted of 218 respondents. The instruments used in the study were the Teacher Job Satisfaction Questionnaire and the Decision…

  2. Parental Compliance to Court-Ordered Treatment Interventions in Cases of Child Maltreatment.

    Science.gov (United States)

    Famularo, Richard; And Others

    1989-01-01

    The study of 136 court cases representing 218 parents of abused or neglected children found parental compliance with court ordered treatment significantly lower in parents presenting with substance abuse and in parents who sexually and/or physically maltreated their children. (Author/DB)

  3. Rose Atoll Site 8P 2/19/2012 6-7M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 8P (14 32.282S, 168 09.218W), between 6 and 7 meters along a permanent transect.

  4. Genetic and bibliographic information: ACTG1 [GenLibi

    Lifescience Database Archive (English)

    Full Text Available Hearing Loss (C09.218.458.341) Nervous System Diseases (C10) > Neurologic Manifestations (C10.597) > Sensat...(C10.597.751.418.341) Pathological Conditions, Signs and Symptoms (C23) > Signs and Symptoms (C23.888) > Neurolog

  5. Small Business Innovation Research (SBIR) Program. FY 1991 Program Solicitation 91.2

    Science.gov (United States)

    1991-07-01

    lidar profilers. These one-dimensional measurements and aircraft measurements are extended to a second space dimension using the temporal evolution...production aircraft with proprotors installed in tilting engine nacelles . With its proprotors in the horizontal position, the V-22 can takeoff, hover, and...188, 218 Light Detecting and Ranging ( LIDAR ) technology. .. .. .. .. .. .. ... ... .. ... .. ... ... 240, 242 light sources

  6. Caloric Intake from Fast Food among Children and Adolescents in the United States, 2011-2012. NCHS Data Brief. Number 213

    Science.gov (United States)

    Vikraman, Sundeep; Fryar, Cheryl D.; Ogden, Cynthia L.

    2015-01-01

    Consumption of fast food has been linked to weight gain in adults. Fast food has also been associated with higher caloric intake and poorer diet quality in children and adolescents. From 1994 through 2006, caloric intake from fast food increased from 10% to 13% among children aged 2-18 years. This report presents the most recent data on the…

  7. Business and Technology Students' Preferences for English-Language Accents: Implications for Business Communication.

    Science.gov (United States)

    Scott, James Calvert; Green, Diana J.; Rosewarne, David

    1997-01-01

    Multiple recordings of a message in various accents were heard by 218 college students, including 26 nonnative English speakers. Ranked English accents in descending order were General American, British, Australian, Indian, Estuary, and Japanese. Perceptual differences were related to gender, ethnicity, nationality, and region. Implications for…

  8. Suurte kunstnike teater? / Madli Pesti

    Index Scriptorium Estoniae

    Pesti, Madli, 1980-

    2008-01-01

    2.-18. maini Berliinis toimunud saksakeelse teatri esindusfestivalist "Theatertreffen 2008", mis toimus sel aastal neljakümne viiendat korda. Lavastustest: Simon Stephensi "Pornograafia" (lav. Sebastian Nübling), Signa Sorenseni ja Arthur Köstleri "Martha Rubini ilmumised", Stephan Kimmigi Schilleri-tõlgendus "Maria Stuart", Gerhart Hauptmanni "Rotid" (lav. Michael Thalheimer), Shakespeare "Hamlet" (lav. Jan Bosse), Christoph Marthaleri "Platz Mangel"

  9. A randomized, placebo-controlled trial of three fixed dosages of prolonged-release OROS methylphenidate in adults with attention-deficit/hyperactivity disorder.

    NARCIS (Netherlands)

    Medori, R.; Ramos-Quiroga, J.A.; Casas, M.; Kooij, J.J.; Niemela, A.; Trott, G.E.; Lee, E.; Buitelaar, J.K.

    2008-01-01

    BACKGROUND: There is increasing recognition of attention-deficit/hyperactivity disorder (ADHD) in adults and the need to evaluate efficacy and safety of methylphenidate treatment in these patients. METHODS: In this double-blind trial, 401 adults with ADHD (218 men; 18-63 years) were randomly assigne

  10. A Model to Predict Retention and Attrition of Hispanic-Americans in the Navy.

    Science.gov (United States)

    1980-10-01

    Frame of Reference. Institute of Comparative Social and Cultural Studies, Inc., 1978. Teske , R. H. C., Jr., & Nelson, B. An analysis of differential...assimilation rates among middle-class Mexican-Americans. Sociological Quarterly, 1976, 17, 2, 218-235. Teske , R. H. C., Jr., & Nelson, B. H

  11. ADHESION OF MUTANS STREPTOCOCCI TO GLASS WITH AND WITHOUT A SALIVARY COATING AS STUDIED IN A PARALLEL-PLATE FLOW CHAMBER

    NARCIS (Netherlands)

    BUSSCHER, HJ; DOORNBUSCH, GI; VANDERMEI, HC

    1992-01-01

    Deposition and adhesion to glass with and without a salivary coating in a parallel-plate flow chamber were studied with four strains of mutans streptococci. Stationary-state adhesion of the strains to uncoated glass ranged from 0.3 x 10(6) cm-2 (Streptococcus rattus HG218) to 12.7 x 10(6) cm-2 (Stre

  12. Tennessee Extension Agents' Perceptions of Performance Appraisal

    Science.gov (United States)

    Donaldson, Joseph L.; French, Russell L.

    2013-01-01

    Performance appraisal is necessary for summative decisions about employees, such as merit pay and promotion. The research reported here describes Extension agent perceptions of their performance appraisal system. The population studied consisted of all Tennessee Extension agents (N = 312). Surveys were completed by 218 respondents, for a completed…

  13. Assessment of 6th Grade Elementary School Students, Their Parents' and Branch Teachers' Perspective on Physical Education Classes

    Science.gov (United States)

    Boyraz, Sirin; Ozbar, Nurper; Yetgin, Meral Kucuk; Koksalan, Burke

    2015-01-01

    A total of 437 volunteers including 54 teachers, 218 6th grade students and 102 parents from Beykoz Elementary Schools participated in this study to understand the perspectives of students, families and teachers on Physical Education classes. The perspectives of students, families and teachers of other branches are identified by survey method.…

  14. The effect of yeast cell wall supplementation on the physiological and acute phase responses of crossbred heifers to endotoxin challenge

    Science.gov (United States)

    A study was conducted to determine the effect of feeding yeast cell wall (YCW) products on the physiological and acute phase responses of crossbred newly-received heifers to endotoxin (lipopolysaccharide; LPS) challenge. Heifers (n=24; 218.9+/-2.4 kg) were obtained from commercial sale barns and tra...

  15. The effect of yeast cell wall supplementation on the metabolic responses of crossbred heifers to endotoxin challenge

    Science.gov (United States)

    This study examined the effect of feeding yeast cell wall (YCW) products on the metabolic responses of newly-received heifers to endotoxin (lipopolysaccharide; LPS) challenge. Heifers (n=24; 218.9±2.4 kg) were obtained from commercial sale barns and transported to the Texas Tech University Beef Cent...

  16. Dried citrus pulp modulates the physiological and acute phase responses of crossbred heifers to an endotoxin challenge

    Science.gov (United States)

    This study examined the effect of feeding dried citrus pulp (CP) pellets on the physiological and acute phase responses (APR) of newly-received crossbred heifers to an endotoxin (lipopolysaccharide; LPS) challenge. Heifers (n=24; 218.3±2.4 kg) were obtained from commercial sale barns and transported...

  17. Vector-Based Ground Surface and Object Representation Using Cameras

    Science.gov (United States)

    2009-12-01

    abbreviation of Conditional Density Propagation [ Isard 1998]. The Particle filter is a model estimation technique using probability distribution...Proceedings of the, 1992, pp. 213-218. M. Isard and A. Blake, "CONDENSATION—Conditional Density Propagation for Visual Tracking," International Journal

  18. Fluorinated amino acids for tumour imaging with positron emission tomography.

    NARCIS (Netherlands)

    Laverman, P.; Boerman, O.C.; Corstens, F.H.M.; Oyen, W.J.G.

    2002-01-01

    The currently preferred radiopharmaceutical for positron emission tomography (PET) in oncology is 2-[(18)F]fluoro-deoxyglucose (FDG). Increased accumulation of this deoxyglucose analogue in tumour cells is based on elevated glucose metabolism by tumour cells and subsequent trapping in the cells. In

  19. 75 FR 47263 - Certain Hot-Rolled Flat-Rolled Carbon-Quality Steel Products From the Russian Federation; Final...

    Science.gov (United States)

    2010-08-05

    ....'' \\1\\ See Initiation of Five-Year (``Sunset'') Review, 75 FR 16437 (April 1, 2010) (Notice of..., 75 FR 16437 (2010). Section 351.218(d)(1)(i) of the Department's regulations provides domestic... International Trade Administration Certain Hot-Rolled Flat-Rolled Carbon-Quality Steel Products From the...

  20. Latent Scope Bias in Categorization

    Science.gov (United States)

    2014-01-01

    Stangor, Lynch, Duan, & Glass, 1992; Tajfel , Billig, Bundy, & Claude, 1971), as well as broader aspects of judgment and decision making (for a review, see...Psychology, 207–218. Tajfel , H., Billig, M. G., Bundy, R. P., & Claude, F. (1971). Social categorization and inter- group behavior. European Journal of

  1. AcEST: BP916146 [AcEST

    Lifescience Database Archive (English)

    Full Text Available lta catalytic subunit OS=Rattus norvegicus GN=Pold1 PE=2 SV=1 Length = 1103 Score = 88.6 bits (218), Expect ...1|DPOD1_MOUSE DNA polymerase delta catalytic subunit OS=Mus musculus GN=Pold1 PE=2 SV=1 Length = 1105 Score

  2. Superconducting magnets. Citations from NTIS data base

    Science.gov (United States)

    Reimherr, G. W.

    1980-10-01

    The cited reports discuss research on materials studies, theory, design and applications of superconducting magnets. Examples of applications include particle accelerators, MHD power generation, superconducting generators, nuclear fusion research devices, energy storage systems, and magnetic levitation. This updated bibliography contains 218 citations, 88 of which are new entries to the previous edition.

  3. 75 FR 60084 - Purified Carboxymethylcellulose from Mexico: Preliminary Results of the First Five-year (“Sunset...

    Science.gov (United States)

    2010-09-29

    ... Initiation from the domestic interested party and respondent interested party, Quimica Amtex S.A. de C.V. (Quimica Amtex), within the 30-day deadline specified in 19 CFR 351.218(d)(3)(i).\\1\\ The Department did not... following weighted-average margins: Quimica Amtex 12.61 percent All Others 12.61 percent Public Comment...

  4. Response of CZT drift-strip detector to X- and gamma rays

    DEFF Research Database (Denmark)

    Kuvvetli, Irfan; Budtz-Jørgensen, Carl; Gerward, Leif

    2001-01-01

    The drift-strip method for improving the energy response of a CdZnTe (CZT) detector to hard X- and gamma rays is discussed. Results for a 10 x 10 x 3 mm(3) detector crystal demonstrate a remarkable improvement of the energy resolution. The full width at half maximum (FWHM) is 2.18 keV (3.6%), 2...

  5. EST Table: D49478 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available D49478 10/09/29 100 %/223 aa dbj|BAF76333.1| ecdysone receptor [Bombyx mori] 10/09/...98-PB 10/09/10 61 %/218 aa gi|121308146|emb|CAL25730.1| ecdysone receptor (isoform A) [Tribolium castaneum] BP118768 ...

  6. Drug: D08275 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08275 Drug Niflumic acid (INN); Niflugel (TN) C13H9F3N2O2 282.0616 282.218 D08275.gif Antiinflammatory...) M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN M02AA Antiinflammatory

  7. 75 FR 32343 - Debt Collection and Administrative Offset for Monies Due the Federal Government

    Science.gov (United States)

    2010-06-08

    ..., Minerals Revenue Management, P.O. Box 25165, MS 61013B, Denver, Colorado 80225. Hand-carry comments or use... questions on procedural issues, contact Hyla Hurst, Regulatory Specialist, Minerals Revenue Management (MRM... Minerals Management Service 30 CFR Part 218 RIN 1010-AD36 Debt Collection and Administrative Offset...

  8. Daily Spiritual Experiences and Psychological Well-Being among US Adults

    Science.gov (United States)

    Ellison, Christopher G.; Fan, Daisy

    2008-01-01

    This study focuses on one of the most significant recent innovations in the conceptualization and measurement of religiousness and spirituality, the Daily Spiritual Experience scale (DSES; Underwood (2006) "Archive for the Psychology of Religion/Archiv fur Religion Psychologie," 28, 181-218). Using data from 1998 and 2004 NORC General…

  9. 33 CFR 401.42 - Passing hand lines.

    Science.gov (United States)

    2010-07-01

    ... behind the splice of the eye; (3) At Iroquois Lock and Lock 8, Welland Canal, both upbound and downbound... vessels of overall length in excess of 218 m in Locks 4 and 5, Welland Canal, shall secure the hand lien... lines. (a) At locks, hand lines shall be secured to the mooring lines and passed as follows: (1)...

  10. Data Fusion Methods for Small Arms Localization Solutions

    Science.gov (United States)

    2012-07-01

    Symmetric Projectiles. 1. 1. Atglen, PA: Schiffer Books , 2004. Print. [7] Fisher, N.I. Statistical Analysis of Circular Data. 1. 1. Cambridge...Cambridge University Press, 2011. 169-218. eBook . <http://ebooks.cambridge.org/ebook.jsf?bid=CBO9780511564345>. [8] Abramowitz, M. and Stegun, I. A. (ed

  11. A Novel Hand-Held Optical Imager with Real-Time Co-Registration Facilities Towards Diagnostic Mammography

    Science.gov (United States)

    2012-01-01

    spectroscopy,” UCI Undergraduate Res. J. II, pp. 43–49, 1999. [11] B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza , T. Pham, L. Svaasand, and J...mammography,” Acad. Ra- diol., vol. 8, pp. 211–218, 2001. [14] N. Shah, A. Cerussi, C. Eker, J. Espinoza , J. Butler, J. Fishkin, R. Hor- nung, and B

  12. Evaluation of real-time PCR for Strongyloides stercoralis and hookworm as diagnostic tool in asymptomatic schoolchildren in Cambodia.

    Science.gov (United States)

    Schär, Fabian; Odermatt, Peter; Khieu, Virak; Panning, Marcus; Duong, Socheat; Muth, Sinuon; Marti, Hanspeter; Kramme, Stefanie

    2013-05-01

    Diagnosis of soil-transmitted helminths such as Strongyloides stercoralis and hookworms (Ancylostoma duodenale and Necator americanus) is challenging due to irregular larval and egg output in infected individuals and insensitive conventional diagnostic procedures. Sensitive novel real-time PCR assays have been developed. Our study aimed to evaluate the real-time PCR assays as a diagnostic tool for detection of Strongyloides spp. and hookworms in a random stool sample of 218 asymptomatic schoolchildren in Cambodia. Overall prevalence of 17.4% (38/218) and 34.9% (76/218) were determined by real-time PCR for S. stercoralis and hookworms, respectively. Sensitivity and specificity of S. stercoralis specific real-time PCR as compared to the combination of Baermann/Koga Agar as gold standard were 88.9% and 92.7%, respectively. For hookworm specific real-time PCR a sensitivity of 78.9% and specificity of 78.9% were calculated. Co-infections were detectable by PCR in 12.8% (28/218) of individuals. S. stercoralis real-time PCR applied in asymptomatic cases showed a lower sensitivity compared to studies undertaken with symptomatic patients with the same molecular tool, yet it proved to be a valid supplement in the diagnosis of STH infection in Cambodia.

  13. EFL Learners' Vocabulary Consolidation Strategy Use and Corresponding Performance on Vocabulary Tests

    Science.gov (United States)

    Lai, Ying-Chun

    2016-01-01

    This study describes English as a Foreign Language (EFL) learners' use of vocabulary consolidation strategies and explores the connection between strategy use and vocabulary learning outcomes. This study included 218 participants who were students from five freshman English classes at a university in Taiwan. Students' self-reports on their use of…

  14. CACNA1A R1347Q: a frequent recurrent mutation in hemiplegic migraine.

    NARCIS (Netherlands)

    Stam, A.H.; Molkot, K.R. van; Kremer, H.P.H.; Gartner, J.; Brown, J.; Leshinsky-Silver, E.; Gilad, R.; Kors, E.E.; Frankhuizen, W.S.; Ginjaar, H.B.; Haan, J.; Frants, R.R.; Ferrari, M.D.; Maagdenberg, A.M. van den; Terwindt, G.M.

    2008-01-01

    Of the 18 missense mutations in the CACNA1A gene, which are associated with familial hemiplegic migraine type 1 (FHM1), only mutations S218L, R583Q and T666M were identified in more than two independent families. Including the four novel families presented here, of which two represent de novo cases,

  15. 77 FR 47337 - Project-Level Predecisional Administrative Review Process

    Science.gov (United States)

    2012-08-08

    ... Forest Service 36 CFR Part 218 RIN 0596-AD07 Project-Level Predecisional Administrative Review Process... establishes the sole process by which the public may file objections seeking predecisional administrative... Rangeland Renewable Resources Planning Act of 1974, and documented with a Record of Decision (ROD)...

  16. Rose Atoll Site 8P 7/29/1999 9-10M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 8P (14 32.282S, 168 09.218W), between 9 and 10 meters along a permanent transect.

  17. Fluid jet polishing of optical surfaces

    NARCIS (Netherlands)

    Fähnle, O.W.; Brug, H. van; Frankena, H.J.

    1998-01-01

    We present a new finishing process that is capable of locally shaping and polishing optical surfaces of complex shapes. A fluid jet system is used to guide a premixed slurry at pressures less than 6 bars to the optical surface. We used a slurry comprising water and 10% #800 SiC abrasives (21.8 μm to

  18. Gender differences in the associations between cortisol and insulin in healthy subjects

    NARCIS (Netherlands)

    Stolk, RP; Lamberts, SWJ; deJong, FH; Pols, HAP; Grobbee, DE

    1996-01-01

    To investigate the role of cortisol in the etiology of insulin resistance in men and women, we examined 218 healthy non-hospitalized elderly, selected from the Rotterdam Study. Free cortisol was assessed by the ratio of fasting serum cortisol over corticosteroid-binding globulin (CBG), and insulin r

  19. Careers in Agriculture: June 1993-March 1997. Quick Bibliography Series No. QB-97-05.

    Science.gov (United States)

    Chapman, Susan

    This bibliography on careers in agriculture was produced by the National Agricultural Library. It contains 218 citations from the AGRICOLA database. The search strategy is included, call numbers are provided for each entry, and abstracts are provided for some citations. The bibliography concludes with an author index and a subject index. (AA)

  20. Microvessel Density But Not Neoangiogenesis Is Associated with (18)F-FDG Uptake in Human Atherosclerotic Carotid Plaques

    DEFF Research Database (Denmark)

    Pedersen, Sune Folke; Græbe, Martin; Hag, Anne Mette Fisker;

    2011-01-01

    Introduction: The vulnerable atherosclerotic lesion exhibits the proliferation of neovessels and inflammation. The imaging modality 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (18FDG-PET) is considered for the identification of vulnerable plaques. Purpose: The purpose of this study...

  1. Rose Atoll Site 8P 7/28/2004 4-5M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 8P (14 32.282S, 168 09.218W), between 4 and 5 meters along a permanent transect.

  2. Rose Atoll Site 8P 7/29/1999 6-7M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 8P (14 32.282S, 168 09.218W), between 6 and 7 meters along a permanent transect.

  3. Ecstasy : [poems] / Marie Under

    Index Scriptorium Estoniae

    Under, Marie, 1883-1980

    2003-01-01

    Autori lühitutvustus lk. 218. Sisu: Ecstasy ; Summer memory ; Night ; Tree with birds / transl. by W. K. Matthews ; How could I sleep ; With myself ; Evening ; The white page ; Accounts to render / transl. by Leonard Fox. Orig.: Ekstaas ; Suvine mälestus ; Öö ; Puu lindudega ; Kuis võiksin magada ; Endaga ; Õhtu ; Valge leht ; Aruand

  4. Relationship between snacking patterns, diet quality and risk of overweight and abdominal obesity in children

    Science.gov (United States)

    Snacking is very common among Americans; the impact of variety of snacking patterns on nutrient intake and weight status is unclear. This study examined the associations of snacking patterns on nutrient intake and weight in U.S. children 2-18 years participating in the 2001-2008 National Health and ...

  5. 77 FR 24415 - Inflation Adjustment of the Aggravated Maximum Civil Monetary Penalty for a Violation of a...

    Science.gov (United States)

    2012-04-24

    ... Federal Railroad Administration 49 CFR Parts 209, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223...); 49 CFR 240.223(a), (b). Further, FRA is revising language in 49 CFR part 209, appendix A, ``Statement..., Transportation. 49 CFR Part 220 Communications, Penalties, Radio, Railroad safety, Reporting and...

  6. Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease

    NARCIS (Netherlands)

    Hagenaars, J. C J P; Wever, P. C.; Vlake, A. W.; Renders, N. H M; van Petersen, A. S.; Hilbink, M.; De Jager-Leclercq, M. G L; Moll, F. L.; Koning, O. H J; Hoekstra, C. J.

    2016-01-01

    Background: The aim of this study is to describe the value of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in diagnosing chronic Q fever in patients with central vascular disease and the added value of18F-FDG PET/CT in the diagnostic combination s

  7. 75 FR 33358 - Duke Energy Carolinas, LLC; McGuire Nuclear Station; Confirmatory Order (Effective Immediately)

    Science.gov (United States)

    2010-06-11

    ... Carolinas, LLC; McGuire Nuclear Station; Confirmatory Order (Effective Immediately) I Duke Energy Carolinas, LLC's (Duke Energy or Licensee) is the holder of License Nos. NPF-9 and NPF-17, issued by the Nuclear... Energy Nuclear Policy Manual, NSD 218.10.1, Revision 9, states in relevant part, that where...

  8. Using Emotional and Social Factors To Predict Student Success.

    Science.gov (United States)

    Pritchard, Mary E.; Wilson, Gregory S.

    2003-01-01

    College academic success and retention have traditionally been predicted using demographic and academic variables. This study moved beyond traditional predictors. A survey of 218 undergraduate students revealed that emotional and social factors (e.g., stress, frequency of alcohol consumption) related to GPA and emotional factors (e.g.,…

  9. High-Quality Draft Genomes from Thermus caliditerrae YIM 77777 and T. tengchongensis YIM 77401, Isolates from Tengchong, China

    Science.gov (United States)

    Mefferd, Chrisabelle C.; Zhou, En-Min; Yu, Tian-Tian; Ming, Hong; Murugapiran, Senthil K.; Huntemann, Marcel; Clum, Alicia; Pillay, Manoj; Palaniappan, Krishnaveni; Varghese, Neha; Mikhailova, Natalia; Stamatis, Dimitrios; Reddy, T. B. K.; Ngan, Chew Yee; Daum, Chris; Duffy, Kecia; Shapiro, Nicole; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Williams, Amanda J.; Woyke, Tanja

    2016-01-01

    The draft genomes of Thermus  tengchongensis YIM 77401 and T. caliditerrae YIM 77777 are 2,562,314 and 2,218,114 bp and encode 2,726 and 2,305 predicted genes, respectively. Gene content and growth experiments demonstrate broad metabolic capacity, including starch hydrolysis, thiosulfate oxidation, arsenite oxidation, incomplete denitrification, and polysulfide reduction. PMID:27125486

  10. Consumption of 100% fruit juice is associated with better nutrient intake and diet quality but not with weight status in children: NHANES 2007-2010

    Science.gov (United States)

    This study examined the impact of various levels of 100% fruit juice (FJ) consumption on intake of nutrients, diet quality, and weight in children using the more recent national data. We conducted a cross-sectional study examining the data from children 2-18 years of age (n=6,090). Intake of nutrien...

  11. Replacing 100% fruit juice with whole fruit results in a trade off of nutrient in the diets of children

    Science.gov (United States)

    The effect of replacing 100% fruit juice (FJ) with whole fruit (WF) on nutrient intake and adequacy in children's diets is unclear. The objective of this study was to model the effect of replacing FJ with WF in children's diets. Data from children 2-18 years of age (n=6,090) participating in the Na...

  12. Exploring the Local Milky Way: M Dwarfs as Tracers of Galactic Populations

    Science.gov (United States)

    2007-12-01

    determinations of M dwarfs are difficult (Woolf & Wallerstein 2006), proxies of metallicity have been employed (Gizis 1997; Lépine et al. 2003; Burgasser...128, 426 Wielen, R. 1977, A&A, 60, 263 Wilson, O., & Woolley, R. 1970, MNRAS, 148, 463 Woolf, V. M., & Wallerstein , G. 2006, PASP, 118, 218 Yanny, B

  13. High-Quality Draft Genomes from Thermus caliditerrae YIM 77777 and T. tengchongensis YIM 77401, Isolates from Tengchong, China.

    Science.gov (United States)

    Mefferd, Chrisabelle C; Zhou, En-Min; Yu, Tian-Tian; Ming, Hong; Murugapiran, Senthil K; Huntemann, Marcel; Clum, Alicia; Pillay, Manoj; Palaniappan, Krishnaveni; Varghese, Neha; Mikhailova, Natalia; Stamatis, Dimitrios; Reddy, T B K; Ngan, Chew Yee; Daum, Chris; Duffy, Kecia; Shapiro, Nicole; Markowitz, Victor; Ivanova, Natalia; Kyrpides, Nikos; Williams, Amanda J; Woyke, Tanja; Li, Wen-Jun; Hedlund, Brian P

    2016-04-28

    The draft genomes of Thermus  tengchongensis YIM 77401 and T. caliditerrae YIM 77777 are 2,562,314 and 2,218,114 bp and encode 2,726 and 2,305 predicted genes, respectively. Gene content and growth experiments demonstrate broad metabolic capacity, including starch hydrolysis, thiosulfate oxidation, arsenite oxidation, incomplete denitrification, and polysulfide reduction.

  14. 77 FR 9627 - Marine Mammals

    Science.gov (United States)

    2012-02-17

    ...; receipt of application. SUMMARY: Notice is hereby given that Robin Baird, Ph.D., Cascadia Research, 218\\1... purposes of the proposed research are to study: (1) Population size and structure, (2) range and movement... recording, underwater observation with a pole cam, and opportunistic sampling (sloughed skin and...

  15. AcEST: DK953186 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ense GN=C... 218 2e-56 sp|P23569|CHSY_PUELO Chalcone synthase OS=Pueraria lobata GN=CHS... 215 2e-55 sp|P300...T 662 +FCT Sbjct: 134 VFCT 137 >sp|P23569|CHSY_PUELO Chalcone synthase OS=Pueraria lobata GN=CHS PE=2 SV=1 L

  16. On the Communication Complexity of Solving a Polynomial Equation

    Science.gov (United States)

    1989-07-01

    of Abelson’s. Finally, the appendix contains certain results from multidimensional calculus that are needed in Section 2. 2 Main Result Let f : D. x D...and Tsitsiklis, J.N., "On the Complexity of Designing Dis- tributed Protocols", Information and Control, 53, 3, 1982, pp. 211-218. [S 65] Spivak , M

  17. What Works in Adult Instruction: The Management, Design and Delivery of Instruction.

    Science.gov (United States)

    1993-06-01

    need to bu explicit. Explicit instruction will result in the students demonstrating significantly greater metacognitive awareness of the content. Cues...and commitment). Reading List: Assinder, W. (1991). Peer teaching. peer learning: One model. ELT Journal. 45(3). 218-229. Bangert-Drowns. R.L.. Kulik

  18. Epicubenol synthase. Origin of the oxygen atom of a bacterial sesquiterpene alcohol.

    Science.gov (United States)

    Cane, D E; Ke, N

    2000-01-17

    Incubation of epicubenol synthase with farnesyl pyrophosphate in the presence of 11.1 atom% H2(18)O gave epicubenol (2) in which the hydroxyl oxygen atom was shown to be derived exclusively from water, as established by GC-selected ion monitoring MS of the derived TMS-epicubenol derivative (15).

  19. Tuning in to Kids: An Emotion-Focused Parenting Program--Initial Findings from a Community Trial

    Science.gov (United States)

    Havighurst, Sophie S.; Wilson, Katherine R.; Harley, Ann E.; Prior, Margot R.

    2009-01-01

    This study evaluated a new group parenting program, Tuning in to Kids, which taught emotion coaching skills to parents of preschool children. In a randomized control trial, 218 primary caregiver parents of children aged 4.0-5.11 years completed questionnaires assessing parent emotion socialization (emotion coaching vs. emotion dismissing), parent…

  20. 78 FR 72706 - Notice of Inventory Completion: Colorado State University, Fort Collins, CO

    Science.gov (United States)

    2013-12-03

    ... in this notice by January 2, 2014. ADDRESSES: Christopher Green, Colorado State University, B-218 Clark Building, c/o Christopher Green, 1787 Campus Delivery, Fort Collins, CO 80525, telephone (970) 213... are present, although burned and unburned animal bone, late prehistoric arrow points, and...