WorldWideScience

Sample records for astatine 218

  1. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  2. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  3. Adsorption interaction of astatine species with quartz and gold surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Serov, A. [Paul Scherrer Institute, Villigen (Switzerland). Lab. for Radiochemistry and Environmental Chemistry; Bern Univ. (Switzerland). Dept. for Chemistry and Biochemistry; Aksenov, N.; Bozhikov, G. [Joint Institute for Nuclear Research, Dubna (RU). Flerov Lab. of Nuclear Reactions] (and others)

    2011-07-01

    The adsorption interaction of various astatine species with quartz and gold surfaces was investigated by gas chromatography methods. Due to variations of the redox potential of the carrier gas elemental astatine, astatine oxide and hypo-astatic acid have been produced. The identification of the astatine compounds is based on the analogy assumption to the gas phase chemistry of the closest homologues in group 17 of the periodic table, iodine and bromine. The deposition temperatures as well as enthalpies of adsorption have been determined for the astatine species. The enhancement of the metallic character within group 17 towards higher Z is clearly confirmed. Macroscopic properties (sublimation enthalpy) of previously unstudied AtO{sub 2} and HAtO were estimated. The determined data for elemental astatine were compared to available literature data. Based on the obtained experimental results possible designs of experiments for studying of chemical properties of the recently discovered element 117 can be suggested. (orig.)

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. CGD 218 COURSE TUTORIAL/ snaptutorial

    OpenAIRE

    mounish

    2015-01-01

    For more classes visit www.snaptutorial.com CGD 218 Week 1 Assignment Why is Visual Literacy Important CGD 218 Week 1 Journal The Evolution of Media   CGD 218 Week 1 DQ 1 Using Visuals to Communicate   CGD 218 Week 2 Assignment Final Project - Step Two   CGD 218 Week 2 DQ 1 Typography in Business   CGD 218 Week 2 DQ 2 Bauhaus Manifesto   CGD 218 Week 3 Assignment Using Photographs from the Web   CGD 218 ...

  6. CGD 218 ASH Course Tutorial / cgd218dotcom

    OpenAIRE

    vasanthi05

    2015-01-01

    CGD 218 Entire Course For more course tutorials visit www.cgd218.com   CGD 218 Week 1 Assignment Why is Visual Literacy Important CGD 218 Week 1 Journal The Evolution of Media CGD 218 Week 1 DQ 1 Using Visuals to Communicate CGD 218 Week 2 Assignment Final Project - Step Two CGD 218 Week 2 DQ 1 Typography in Business CGD 218 Week 2 DQ 2 Bauhaus Manifesto CGD 218 Week 3 Assignment Using Photographs from the Web CGD 218 Week 3 Journal Visual Comm...

  7. Discovery of the astatine, radon, francium, and radium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  8. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  9. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  10. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  11. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  12. CGD 218 ASH COURSES TUTORIAL/UOPHELP

    OpenAIRE

    BROADY

    2015-01-01

    For more course tutorials visit www.uophelp.com       CGD 218 Week 1 Assignment Why is Visual Literacy Important CGD 218 Week 1 Journal The Evolution of Media   CGD 218 Week 1 DQ 1 Using Visuals to Communicate   CGD 218 Week 2 Assignment Final Project - Step Two   CGD 218 Week 2 DQ 1 Typography in Business   CGD 218 Week 2 DQ 2 Bauhaus Manifesto   CGD 218 Week 3 Assignment Using Photographs...

  13. CGD 218 ash course tutorial / uophelp

    OpenAIRE

    uophelp

    2015-01-01

    For more course tutorials visit www.uophelp.com CGD 218 Week 1 Assignment Why is Visual Literacy Important CGD 218 Week 1 Journal The Evolution of Media   CGD 218 Week 1 DQ 1 Using Visuals to Communicate   CGD 218 Week 2 Assignment Final Project - Step Two   CGD 218 Week 2 DQ 1 Typography in Business   CGD 218 Week 2 DQ 2 Bauhaus Manifesto   CGD 218 Week 3 Assignment Using Photographs from the Web   CGD ...

  14. 49 CFR 571.218 - Standard No. 218; Motorcycle helmets.

    Science.gov (United States)

    2010-10-01

    ... Motor Vehicle Safety Standards § 571.218 Standard No. 218; Motorcycle helmets. S1. Scope. This standard... and other motor vehicle users resulting from head impacts. S3. Application. This standard applies to all helmets designed for use by motorcyclists and other motor vehicle users. S4. Definitions....

  15. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  16. CGD 218 UOP Course Tutorial/ Tutorialrank

    OpenAIRE

    SICEN

    2015-01-01

                      For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 4 Times, Rating: A+     CGD 218 Week 1 Assignment Why is Visual Literacy Important CGD 218 Week 1 Journal The Evolution of Media CGD 218 Week 1 DQ 1 Using Visuals to Communicate CGD 218 Week 2 Assignment Final Project - Step Two CGD 218 Week 2 DQ 1 Typography in Business CGD 218 Week 2 DQ 2 Bauhaus Manife...

  17. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom;

    2015-01-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...... and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting...... vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method...

  18. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  19. 49 CFR 218.22 - Utility employee.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Utility employee. 218.22 Section 218.22..., DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Blue Signal Protection of Workers § 218.22 Utility employee. (a) A utility employee shall be subject to the Hours of Service Act, and the requirements...

  20. 49 CFR 218.35 - Yard limits.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Yard limits. 218.35 Section 218.35 Transportation... TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Trains and Locomotives § 218.35 Yard limits. (a) After August 1, 1977, yard limits must be designated by— (1) Yard limit signs, and (2) Timetable, train...

  1. 36 CFR 218.6 - Reviewing officer.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Reviewing officer. 218.6 Section 218.6 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE PREDECISIONAL... Authorized by the Healthy Forests Restoration Act of 2003 § 218.6 Reviewing officer. The reviewing...

  2. 22 CFR 218.33 - Mediation.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Mediation. 218.33 Section 218.33 Foreign... § 218.33 Mediation. (a) Referral of complaints for mediation. The agency will refer to the Federal Mediation and Conciliation Service all complaints that: (1) fall within the jurisdiction of...

  3. 49 CFR 218.9 - Civil penalty.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Civil penalty. 218.9 Section 218.9 Transportation... TRANSPORTATION RAILROAD OPERATING PRACTICES General § 218.9 Civil penalty. Any person (an entity of any type... requirement of this part or causes the violation of any such requirement is subject to a civil penalty of...

  4. 42 CFR 438.218 - Enrollee information.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Enrollee information. 438.218 Section 438.218 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... and Operation Standards § 438.218 Enrollee information. The requirements that States must meet...

  5. 7 CFR 58.218 - Surge tanks.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Surge tanks. 58.218 Section 58.218 Agriculture....218 Surge tanks. If surge tanks are used for hot milk, and temperatures of product including foam being held in the surge tank during processing, is not maintained at a minimum of 150 °F, then two...

  6. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  7. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  8. Dicty_cDB: SLA218 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLA218 (Link to dictyBase) - - - Contig-U16455-1 SLA218Z (Link... to Original site) - - SLA218Z 592 - - - - Show SLA218 Library SL (Link to library) Clone ID SLA218 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLA2-A/SLA218Q.Seq.d/ Representative seq. ID SLA21...8Z (Link to Original site) Representative DNA sequence >SLA218 (SLA218Q) /CSM/SL/SLA2-A/SLA218Q.Seq.d/ XXXXX...TAATAATTTT AA sequence update 1997. 5. 7 Translated Amino Acid sequence ---LSTEVKSVEMHHEQLPEARPGDNVGFNVKNVSV

  9. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  10. 10 CFR 218.32 - Review.

    Science.gov (United States)

    2010-01-01

    ... requirements stated in 10 CFR 205.9 in addition to the requirements stated in this section. (2) If the... documents submitted under this subpart, the procedures set out in 10 CFR 205.9(f) shall apply. (c) When to... 10 Energy 3 2010-01-01 2010-01-01 false Review. 218.32 Section 218.32 Energy DEPARTMENT OF...

  11. 9 CFR 381.218 - Criminal offenses.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Criminal offenses. 381.218 Section 381... CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Detention; Seizure and Condemnation; Criminal Offenses § 381.218 Criminal offenses. The Act contains criminal provisions with respect to numerous...

  12. 22 CFR 218.11 - Standards.

    Science.gov (United States)

    2010-04-01

    ... prohibited are set out in part 90 (primarily subpart B) of 45 CFR. ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Standards. 218.11 Section 218.11 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Standards for Determining Age Discrimination §...

  13. 27 CFR 24.218 - Other wine.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Other wine. 24.218 Section... THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.218 Other wine. (a) General. Other than standard wine not included in other sections in this subpart are considered other wine....

  14. 36 CFR 21.8 - Employee certification.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Employee certification. 21.8 Section 21.8 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR HOT... Superintendent upon the completion of an examination. (d) Employees engaged as bath attendants will be...

  15. CGD 218 ASHFORD Course Tutorial/TutorialRank

    OpenAIRE

    makenz

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 4 Times, Rating: A+   CGD 218 Week 1 Assignment Why is Visual Literacy Important CGD 218 Week 1 Journal The Evolution of Media CGD 218 Week 1 DQ 1 Using Visuals to Communicate CGD 218 Week 2 Assignment Final Project - Step Two CGD 218 Week 2 DQ 1 Typography in Business CGD 218 Week 2 DQ 2 Bauhaus Manifesto CGD 218 Week 3 Assignment Using Photographs from the Web CGD 218 We...

  16. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  17. 40 CFR 98.218 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Miscellaneous Uses of Carbonate § 98.218 Definitions. All terms used in this subpart... Table U-1 to Subpart U of Part 98—CO2 Emission Factors for Common Carbonates Mineral name—carbonate...

  18. 50 CFR 218.104 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ... Mitigation. (a) When conducting training and utilizing the sound sources or explosives identified in § 218..., Mitigation Measures Message or Environmental Annex to the Operational Order shall be issued to further... radius around the sound source is clear of marine mammals. (xii) Active sonar levels...

  19. 31 CFR 31.218 - Enforcement.

    Science.gov (United States)

    2010-07-01

    ... Conflicts of Interest § 31.218 Enforcement. (a) Compliance with these rules concerning conflicts of interest... interest or a personal conflict of interest and denial of payment for that work. (2) Termination of the..., referral to the Department of Justice for prosecution of the retained entity and/or its officers...

  20. 5 CFR 179.218 - Additional administrative collection action.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Additional administrative collection action. 179.218 Section 179.218 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Salary Offset § 179.218 Additional administrative collection...

  1. 14 CFR 21.8 - Approval of articles.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Approval of articles. 21.8 Section 21.8 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS General § 21.8 Approval of articles. If an article is required to...

  2. 49 CFR 218.80 - Movement of occupied camp cars.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Movement of occupied camp cars. 218.80 Section 218... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars § 218.80 Movement of occupied camp cars. Occupied cars may not be humped or flat switched unless coupled...

  3. 30 CFR 218.301 - Method of payment.

    Science.gov (United States)

    2010-07-01

    ... Method of payment. The payor shall tender all payments in accordance with 30 CFR 218.51. ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Method of payment. 218.301 Section 218.301 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE...

  4. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  5. 49 CFR 173.218 - Fish meal or fish scrap.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Fish meal or fish scrap. 173.218 Section 173.218... Fish meal or fish scrap. (a) Except as provided in Column (7) of the HMT in § 172.101 of this subchapter, fish meal or fish scrap, containing at least 6%, but not more than 12% water, is authorized...

  6. 29 CFR 825.218 - Substantial and grievous economic injury.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Substantial and grievous economic injury. 825.218 Section... Medical Leave Act § 825.218 Substantial and grievous economic injury. (a) In order to deny restoration to... cause “substantial and grievous economic injury” to the operations of the employer, not whether...

  7. 30 CFR 218.155 - Method of payment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Method of payment. 218.155 Section 218.155....155 Method of payment. (a) Payment of royalties and rentals. With the exception of first-year rental... notice of each lease offering. EFT may be used as a method of payment for the one-fifth bonus bid...

  8. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  9. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  10. Snail-Killing Effects of Streptomyces 218 Powder

    Directory of Open Access Journals (Sweden)

    V.O. Aina

    2012-12-01

    Full Text Available This study is aimed at finding out the snail-killing effects of Streptomyces 218 powder on Oncomelania hupensis snails which are the vectors or intermediate host of Schiltosoma Japonicum (intestinal schistosomiasis in china the tests were carried out in the laboratory and on the field. The snail-killing effects of Streptomyces218 powder, isolated from snail habitat at Anchang Village of Anxiang country in China was tested using the immersion and spraying methods. The tests on the Oncomelania hupensis snails which are intermediate host of Streptomyces japonicum infection were carried out in the laboratory and in the field. The mean corrected snail mortalities of the immersion technique in the laboratory were 81.70 and 98.63% in 10 ppm of 218 solutions after 24 and 48 h, respectively. The mean corrected snail mortalities of the spraying tests in the laboratory were 82.90 and 87.90% at 3 and 5 days, respectively with 10 g/m2 218 powders. The snail-killing ability of 218 powders on the field determines by immersion and spraying methods were comparable to that of the chemical molluscicide-Niclosamide. The corrected snail mortality at 150 ppm of 218 powder (g/m2 and at 2 ppm of Niclosamide by immersion was 100% at the second time test after 24, 48 and 72 h. In the field spraying test, the mean corrected snail mortality at 100 ppm of 218 powders were 61.96 and 70.00% after 3 and 7 days of spraying respectively. At 2 ppm niclosamide, this was found to be 65.58 and 63.81%, respectively. The effective ingredients for the snail-killing are found to be located in the spore chains. Streptomyces 218 powder, although at higher concentrations, seems to be a promising mollusciciding biological agent. If developed further, this could compliment existing mollusciciding agents.

  11. Snail-Killing Effects of Streptomyces 218 Powder

    OpenAIRE

    V.O. Aina; A.A.J. Adewumi; C.O. Yao; M.Z. Shi; Hu, D. Y.; W.H. Chai

    2012-01-01

    This study is aimed at finding out the snail-killing effects of Streptomyces 218 powder on Oncomelania hupensis snails which are the vectors or intermediate host of Schiltosoma Japonicum (intestinal schistosomiasis) in china the tests were carried out in the laboratory and on the field. The snail-killing effects of Streptomyces218 powder, isolated from snail habitat at Anchang Village of Anxiang country in China was tested using the immersion and spraying methods. The tests on the Oncomelania...

  12. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  13. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  14. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  15. 18 CFR 157.218 - Changes in customer name.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Changes in customer... Act for Certain Transactions and Abandonment § 157.218 Changes in customer name. (a) Automatic... reflect the change in the name of an existing customer, if the certificate holder has filed any...

  16. MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Ying-fei [Institute Guangzhou of Advanced Technology, Chinese Academy of Sciences, Guangzhou (China); Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong (China); Zhang, Li [School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (China); Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong (China); Waye, Mary Miu Yee [School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (China); Fu, Wei-ming, E-mail: wm.fu@giat.ac.cn [Institute Guangzhou of Advanced Technology, Chinese Academy of Sciences, Guangzhou (China); School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (China); Zhang, Jin-fang, E-mail: zhangjf06@cuhk.edu.hk [Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong (China); School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong (China); Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen (China)

    2015-05-15

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

  17. MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

    International Nuclear Information System (INIS)

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways

  18. 36 CFR 223.218 - Consistency with plans, environmental standards, and other management requirements.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Consistency with plans, environmental standards, and other management requirements. 223.218 Section 223.218 Parks, Forests, and Public... Special Forest Products § 223.218 Consistency with plans, environmental standards, and other...

  19. 12 CFR 218.741 - Exemption for banks effecting transactions in money market funds.

    Science.gov (United States)

    2010-01-01

    ... money market funds. 218.741 Section 218.741 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS... EXCHANGE ACT OF 1934 (REGULATION R) § 218.741 Exemption for banks effecting transactions in money market... issued by a money market fund, provided that: (1) The bank either (i) Provides the customer, directly...

  20. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  1. 9 CFR 93.218 - Import permits and applications for inspection for poultry.

    Science.gov (United States)

    2010-01-01

    ... inspection for poultry. 93.218 Section 93.218 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND...

  2. 49 CFR 218.75 - Methods of protection for camp cars.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Methods of protection for camp cars. 218.75... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Occupied Camp Cars § 218.75 Methods of protection for camp cars. When camp cars requiring protection are on either main...

  3. 47 CFR 95.803 - 218-219MHz Service description.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false 218-219MHz Service description. 95.803 Section 95.803 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO... description. (a) The 218-219 MHz Service is authorized for system licensees to provide communication...

  4. MicroRNA-218 modulates activities of glioma cells by targeting HMGB1

    Science.gov (United States)

    Gu, Jianjun; Xu, Rong; Li, Yaxing; Zhang, Jianhe; Wang, Shousen

    2016-01-01

    To explore the effects of microRNA-218 (miR-218) on glioma cell lines and the related mechanism. U251 and U87 cells were transfected with negative control, miR-218 mimic or miR-218 inhibitor using lipofectamine 2000. The expressions of mRNA and proteins were detected with qRT-PCR and Western blotting. The cell proliferation, apoptosis, migration and invasion were studied using MTT, flow cytometry, Transwell assay and scratch-wound assay, respectively. The targeting effect of HMGB1 by miR-218 was measured with luciferase reporter assay. The results showed that miR-218 was significantly downregulated while HMGB1 was upregulated in both glioma cell lines. Transfection of miR-218 significantly reduced the cell viability and colony formation, increased cell apoptosis and arrested cell in G0/G1 phase. Transfection of miR-218 also decreased the invasion and migration of glioma cells. The expressions of HMGB1, RAGE, cyclin D1 and MMP-9 were downregulated while the expression of caspase-9 was upregulated by miR-218. Silencing HMGB1 increased the expression of RAGE, cyclin D1, MMP-9 but decreased the expression of caspase-9 in U251 and U87 cells. Co-transfection with pcHMGB1 and miR-218 significantly decreased the growth inhibition and increased the apoptosis of glioma cells while these effects were abolished in glioma cells co-transfected with HMGB1 siRNA and miR-218 inhibitor. In addition, co-transfection with pcHMGB1 and miR-218 inhibitor increased the invasiveness of U251 and U87 cells. These findings suggested that miR-218 may negatively regulate HMGB-mediated suppression of RAGE to regulate cell proliferation, apoptosis and invasion, and that intervention of miR-218-HMGB1-RAGE may be useful for developing potential clinical strategies. PMID:27725858

  5. microRNA-218 Inhibits Oxygen-induced Retinal Neovascularization via Reducing the Expression of Roundabout 1

    Directory of Open Access Journals (Sweden)

    Shuang Han

    2016-01-01

    Conclusions: Our experiments showed that restoration of miR-218 inhibited retinal angiogenesis via targeting Robo1. MiR-218 contributed to the inhibition of retinal angiogenesis and miR-218 might be a new therapeutic target for preventing RNV.

  6. miR-218 Involvement in Cardiomyocyte Hypertrophy Is Likely through Targeting REST

    OpenAIRE

    Jing-Jing Liu; Cui-Mei Zhao; Zhi-Gang Li; Yu-Mei Wang; Wei Miao; Xiu-Juan Wu; Wen-Jing Wang; Chang Liu; Duo Wang; Kang Wang; Li Li; Lu-Ying Peng

    2016-01-01

    MicroRNAs (miRNAs) have been identified as key players in cardiomyocyte hypertrophy, which is associated with significant risks of heart failure. However, many microRNAs are still not recognized for their functions in pathophysiological processes. In this study, we evaluated effects of miR-218 in cardiomyocyte hypertrophy using both in vitro and in vivo models. We found that miR-218 was evidently downregulated in a transverse aortic constriction (TAC) mouse model. Overexpression of miR-218 is...

  7. 23 CFR 646.218 - Simplified procedure for accelerating grade crossing improvements.

    Science.gov (United States)

    2010-04-01

    ... ENGINEERING AND TRAFFIC OPERATIONS RAILROADS Railroad-Highway Projects § 646.218 Simplified procedure for... preliminary engineering costs may include those incurred in selecting crossings to be improved,...

  8. MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor.

    Directory of Open Access Journals (Sweden)

    Jun Tie

    2010-03-01

    Full Text Available MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and function of miR-218 in gastric cancer (GC metastasis. miR-218 expression is decreased along with the expression of one of its host genes, Slit3 in metastatic GC. However, Robo1, one of several Slit receptors, is negatively regulated by miR-218, thus establishing a negative feedback loop. Decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis. The restoration of miR-218 suppresses Robo1 expression and inhibits tumor cell invasion and metastasis in vitro and in vivo. Taken together, our results describe a Slit-miR-218-Robo1 regulatory circuit whose disruption may contribute to GC metastasis. Targeting miR-218 may provide a strategy for blocking tumor metastasis.

  9. MicroRNA-218在肿瘤中的研究进展

    Institute of Scientific and Technical Information of China (English)

    龙倩; 周航

    2016-01-01

    微小 RNA (microRNA ,miRNA)是一类内源性非编码小 RNA ,可调控不同基因的表达,从而改变细胞和生物体的表型。微小 RNA -218(MicroRNA -218,miR -218)的异常表达可导致细胞的增殖、分化、凋亡异常,与肿瘤的发生发展及预后密切相关。本文简述了 miR -218与女性生殖系统肿瘤、消化道肿瘤、颅内肿瘤、呼吸道肿瘤、泌尿生殖系肿瘤之间的关系,拟出 miR -218可能的调控机制,有助于为肿瘤的诊断和治疗提供新的靶点。%MicroRNAs (miRNAs) are small endogenous non - coding RNAs w hich can regulate gene expression differentlly ,and thus alter cell and biosome phenotype .Abnormal expression of microRNA - 218(miR - 218) can cause disorder of cell's differentiation ,proliferation ,apoptosis ,w hich is closely related to the occurrence and development of tumor .T his paper descripted the relationship between miR - 218 and tumors of female reproduc-tive system ,gastrointestinal tract ,brain ,respiratory and genitourinary ,and prepared some regulatory mechanisms to help provide new targets for cancer diagnosis and treatment .

  10. A clinical positron emission tomography facility. 2-18FDG studies: Development and results

    International Nuclear Information System (INIS)

    Two different types of accelerators have been used for production of (18F)fluoride, and the isotope produced has been used for radiolabelling of 2-fluoro-2-deoxy-D-glucose (2-18FDG). A rotating PET scanner, based on two scintillation camera heads, has been developed and used for human 2-18FDG studies. The suitability of an energy window in the Compton region for imaging 511 keV photons in scintillation camera systems has been evaluated. A new simplified method for normalizing clinical 2-18FDG results has been developed and validated, using erythrocytes as a reference tissue, requiring only one blood sample in the middle of the PET scan to calculate the integrated 2-18FDG input function with an accuracy better than 8 percent. An investigation using 2-18FDG PET to monitor the effect of therapy in advanced head and neck cancer patients has been performed. We found that low initial metabolic rate of glucose (MRG) predicted a complete local response. The second PET examination gave no further information for this group. In the group of primary tumours and lymph node metastases representing a combination of high initial MRG and small decrease in MRG at he second PET examination, the outcome was unfavourable. An accurate normalization of 2-18FDG uptake was essential to evaluate the results of this study. 239 refs, 10 tabs

  11. A pri-miR-218 variant and risk of cervical carcinoma in Chinese women

    Directory of Open Access Journals (Sweden)

    Shi Ting-Yan

    2013-01-01

    Full Text Available Abstract Background MicroRNA (miRNA-related single nucleotide polymorphisms (SNPs may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few studies have investigated roles of miRNA-related SNPs in the etiology of cervical carcinoma. Methods In this case–control study of 1,584 cervical cancer cases and 1,394 cancer-free female controls, we investigated associations between two miR-218-related SNPs involved in the LAMB3-miR-218 pathway and the risk of cervical carcinoma in Eastern Chinese women. Results We found that the pri-miR-218 rs11134527 variant GG genotype was significantly associated with a decreased risk of cervical carcinoma compared with AA/AG genotypes (adjusted OR=0.77, 95% CI=0.63-0.95, P=0.015. However, this association was not observed for the miR-218 binding site SNP (rs2566 on LAMB3. Using the multifactor dimensionality reduction analysis, we observed some evidence of interactions of these two SNPs with other risk factors, especially age at primiparity and menopausal status, in the risk of cervical carcinoma. Conclusions The pri-miR-218 rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women. Larger, independent studies are warranted to validate our findings.

  12. MicroRNA-218 inhibits the proliferation and metastasis of esophageal squamous cell carcinoma cells by targeting BMI1.

    Science.gov (United States)

    Wang, Ting; Chen, Tengfei; Niu, Hua; Li, Chang; Xu, Chun; Li, Yuanyuan; Huang, Rui; Zhao, Jun; Wu, Shuyan

    2015-07-01

    MicroRNAs (miRNAs or miRs) play a pivotal role in esophageal carcinogenesis either as oncogenes or as tumor suppressor genes. In the present study, we found that the expression level of miR-218 was significantly reduced in esophageal squamous cell carcinoma (ESCC) tissues and ESCC cell lines. Moreover, its expression was found to correlate with the clinicopathological stage of ESCC; miR-218 expression was lower in the stage III tissue samples than in the stage I and II tissue samples. Furthermore, the decreased expression of miR-218 was found to be associated with an enhanced ESCC cell proliferation and metastasis. Western blot analysis and luciferase reporter assay revealed that miR-218 decreased BMI1 expression by binding to the putative binding sites in its 3'-untranslated region (3'-UTR). The BMI1 mRNA expression levels were markedly increased and negatively correlated with the miR-218 expression level in the ESCC tissues. Functional analyses revealed that the restoration of miR-218 expression inhibited ESCC cell proliferation, migration and invasion and promoted apoptosis. The knockdown of BMI1 by siRNA showed the same phenocopy as the effect of miR-218 on ESCC cells, indicating that BMI1 was a major target of miR-218. In the present study, our findings confirm miR-218 as a tumor suppressor and identify BMI1 as a novel target of miR-218 in ESCC. Therefore, miR-218 may prove to be a useful biomarker for monitoring the initiation and development of ESCC, and may thus be an effective therapeutic target in ESCC.

  13. 17 CFR 274.218 - Form N-8F, application for deregistration of certain registered investment companies.

    Science.gov (United States)

    2010-04-01

    ...) (15 U.S.C. 80a-3(c)(7)) of the Act; or (d) Has become a business development company. Editorial Note... registered investment company; (b) Has distributed substantially all of its assets to its shareholders and... deregistration of certain registered investment companies. 274.218 Section 274.218 Commodity and...

  14. 12 CFR 218.722 - Exemption allowing banks to calculate trust and fiduciary compensation on a bank-wide basis.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Exemption allowing banks to calculate trust and fiduciary compensation on a bank-wide basis. 218.722 Section 218.722 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM EXCEPTIONS FOR BANKS FROM THE DEFINITION OF BROKER IN THE SECURITIES EXCHANGE ACT OF...

  15. MicroRNA-218 promotes high glucose-induced apoptosis in podocytes by targeting heme oxygenase-1.

    Science.gov (United States)

    Yang, Haibo; Wang, Qingjun; Li, Sutong

    2016-03-18

    Emerging evidence has demonstrated that microRNAs (miRNAs) play a mediatory role in the pathogenesis of diabetic nephropathy. In this study, we found that miR-218 was upregulated in high glucose (HG) treated podocytes, which are essential components of the glomerular filtration barrier and a major prognostic determinant in diabetic nephropathy. Additionally, up-regulation of miR-218 was accompanied by an increased rate of podocyte death and down-regulation in the level of nephrin, a key marker of podocytes. However, inhibition of miR-218 exerted the opposite effect. In addition, the dual-luciferase reporter assay showed that miR-218 directly targeted the 3'-untranslated region of heme oxygenase-1 (HO-1), and further study confirmed an increase of HO-1 in HG-treated podocytes transfected with anti-miR-218. Knockdown of HO-1 blocked the anti-apoptotic effect of anti-miR-218. Furthermore, inhibition of miR-218 was associated with decreased expression of the known pro-apoptotic molecule p38-mitogen-activated protein kinase (p38-MAPK) activation. Following preconditioning with SB203580, an inhibitor of p38-MAPK, the stimulatory effect of HG on podocyte apoptosis was strikingly ameliorated. These findings suggested that miR-218 accelerated HG-induced podocyte apoptosis through directly down-regulating HO-1 and facilitating p38-MAPK activation. PMID:26876575

  16. 30 CFR 218.101 - Royalty and rental remittance (naval petroleum reserves).

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Royalty and rental remittance (naval petroleum... INCENTIVES Oil and Gas, Onshore § 218.101 Royalty and rental remittance (naval petroleum reserves). Remittance covering payments of royalty or rental on naval petroleum reserves must be accomplished...

  17. 7 CFR 1951.218 - Use of Rural Development loans and grants for other purposes.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Use of Rural Development loans and grants for other... Servicing of Community and Direct Business Programs Loans and Grants § 1951.218 Use of Rural Development... the Consolidated Farm and Rural Development Act, as amended; and (3) Satisfies such...

  18. 17 CFR 249.218 - Form 18, for foreign governments and political subdivisions thereof.

    Science.gov (United States)

    2010-04-01

    ... Federal Register citations affecting Form 18, see the List of CFR Sections Affected, which appears in the... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form 18, for foreign... for Registration of Securities on National Securities Exchanges and Similar Matters § 249.218 Form...

  19. 20 CFR 408.218 - Do you meet the SSI eligibility requirements?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Do you meet the SSI eligibility requirements... CERTAIN WORLD WAR II VETERANS SVB Qualification and Entitlement Ssi Eligibility § 408.218 Do you meet the SSI eligibility requirements? For SVB purposes, you are eligible for SSI for a given month if all...

  20. 20 CFR 218.13 - When a widow(er) annuity begins.

    Science.gov (United States)

    2010-04-01

    ... the month in which the claimant attains full retirement age; or (iii) The first day of the sixth month... 62 but under full retirement age. The earliest date permitted by law is the latest of— (A) The first... Section 218.13 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT...

  1. 20 CFR 218.36 - When an employee disability annuity ends.

    Science.gov (United States)

    2010-04-01

    ... month in which the employee attains full retirement age (the disability annuity is changed to an age... becomes entitled. When a disability annuity ends before an employee attains full retirement age, any....36 Section 218.36 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE...

  2. 20 CFR 218.26 - Work started after annuity beginning date.

    Science.gov (United States)

    2010-04-01

    ... RETIREMENT ACT ANNUITY BEGINNING AND ENDING DATES How Work and Special Payments Affect an Employee, Spouse, or Divorced Spouse Annuity Beginning Date § 218.26 Work started after annuity beginning date. (a... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Work started after annuity beginning...

  3. 20 CFR 218.16 - When a surviving divorced spouse annuity begins.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false When a surviving divorced spouse annuity... RAILROAD RETIREMENT ACT ANNUITY BEGINNING AND ENDING DATES When an Annuity Begins § 218.16 When a surviving divorced spouse annuity begins. (a) A surviving divorced spouse annuity begins on the later of either...

  4. 49 CFR Appendix D to Part 218 - Requirements and Considerations for Implementing Technology Aided Point Protection

    Science.gov (United States)

    2010-10-01

    ... to be properly qualified (see § 218.95(a)(2)) and the technology must work as intended. Most... track ahead of the shoving or pushing move is clear pursuant to the definition of “track is clear” in... Diagnostic Team shall evaluate the crossing. The diagnostic team shall have representatives from the...

  5. microRNA-218 Inhibits Oxygen-induced Retinal Neovascularization via Reducing the Expression of Roundabout 1

    Institute of Scientific and Technical Information of China (English)

    Shuang Han; Yi-Chun Kong; Bei Sun; Quan-Hong Han; Ying Chen; Yu-Chuan Wang

    2016-01-01

    Background:The mechanisms of pathological retinal neovascularization (RNV) remain unknown.Several microRNAs were reported to be involved in the process of RNV.Oxygen-induced retinopathy (OIR) is a useful model to investigate RNV.Our present work explored the expression and the role of microRNA-128 (miR-218) in oxygen-induced RNV.Methods:OIR was used to establish RNV model.The expression level ofmiR-218 in the retina from OIR mice was assessed by quantitative real-time reverse transcfiptase polymerase chain reaction.Fluorescein angiography was performed in retinae of OIR mice,and RNV was quantified by hematoxylin and eosin staining to evaluate the effect of pCDH-CMV-miR-218 intravitreal injection on RNV in OIR mice.Roundabout 1 (Robo 1) expression was detected by Western blotting in mouse retinal vascular endothelial cells expressing a high or low level ofmiR-218 and retinal tissues from OIR mice.Cell migration was evaluated by scratch wound assay.Results:In OIR mice,the expression level of miR-218 was significantly down-regulated (P =0.006).Retinal Robo1 expression was significantly increased at both mRNA and protein levels (P =0.001,0.008;respectively),miR-218 intravitreal injection inhibited retinal angiogenesis in OIR mice,and the restoration of miR-218 in retina led to down-regulation of Robo 1.Conclusions:Our experiments showed that restoration of miR-218 inhibited retinal angiogenesis via targeting Robo 1.MiR-218 contributed to the inhibition of retinal angiogenesis and miR-218 might be a new therapeutic target for preventing RNV.

  6. miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-{beta}

    Energy Technology Data Exchange (ETDEWEB)

    Song, Libing, E-mail: lb.song1@gmail.com [State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060 (China); Huang, Quan; Chen, Kun [Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080 (China); Liu, Liping [Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080 (China); Lin, Chuyong; Dai, Ting [Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080 (China); Yu, Chunping [State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060 (China); Wu, Zhiqiang [Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080 (China); Li, Jun, E-mail: junli99@gmail.com [Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080 (China)

    2010-11-05

    Research highlights: {yields} miR-218 is markedly downregulated in glioma cell lines and in primary glioma tissues. {yields} Upregulation of miR-218 dramatically reduces the invasive ability of glioma cells. {yields} Ectopic expression of miR-218 inactivates IKK-{beta}/NF-{kappa}B signaling pathway. {yields} miR-218 directly targets the 3'-untranslated region (3'-UTR) of IKK-{beta}. -- Abstract: Aberrant activation of nuclear factor-kappa B (NF-{kappa}B) pathway has been proven to play important roles in the development and progression of cancers. Activation of NF-{kappa}B via the classical pathway is modulated by I{kappa}Bs kinase (IKK-{beta}). However, the mechanism underlying the epigenetic regulation of IKK-{beta}/NF-{kappa}B pathway remains largely unknown. In this study, we found that the expression level of miR-218 was markedly downregulated in glioma cell lines and in human primary glioma tissues. Upregulation of miR-218 dramatically reduced the migratory speed and invasive ability of glioma cells. Furthermore, we showed that ectopically expressing miR-218 in glioma cells resulted in downregulation of matrix metalloproteinase-9 (MMP-9) and reduction in NF-{kappa}B transactivity at a transcriptional level, but inhibition of miR-218 enhanced the expression of MMP-9 and transcriptional activity of NF-{kappa}B. Moreover, we showed that miR-218 inactivated the NF-{kappa}B pathway through downregulating IKK-{beta} expression by directly targeting the 3'-untranslated region (3'-UTR) of IKK-{beta}. Taken together, our results suggest that miR-218 plays an important role in preventing the invasiveness of glioma cells, and our results present a novel mechanism of miRNA-mediated direct suppression of IKK-{beta}/NF-{kappa}B pathway in gliomas.

  7. MiR-218 Inhibited Growth and Metabolism of Human Glioblastoma Cells by Directly Targeting E2F2.

    Science.gov (United States)

    Zhang, Yaxuan; Han, Dongfeng; Wei, Wenjin; Cao, Wenping; Zhang, Rui; Dong, Qingsheng; Zhang, Junxia; Wang, Yingyi; Liu, Ning

    2015-11-01

    In recent years, microRNA has become a hotspot in research on diseases, especially in the initiation and progression of different types of cancer. In this study, we found that miR-218 could inhibit growth and metabolism in gliomas by directly targeting E2F2. First, we obtained data from the Chinese Glioma Genome Atlas (CGGA) database to analyze miR-218 expression in different grades of gliomas. The effects of miR-218 on cell cycle progression and cell proliferation in U87 and U251 cell lines were investigated by flow cytometry, specifically CCK8 assay and tablet cloning, respectively. Glucose consumption and lactate production of glioma cell lines were measured by correlative test kits. Furthermore, we used Western blot analysis and luciferase reporter assay to identify the direct and functional target of miR-218. Data from the CGGA database and real-time quantitative reverse transcription-PCR demonstrated that miR-218 was obviously reduced in human glioblastoma tissues, as well as in the cell lines. When miR-218 level was elevated in vitro, cell cycle progression was arrested in the G1 phase, and cell proliferation was dramatically inhibited. Both glucose consumption and lactate production of glioma cells were significantly reduced. Western blot analysis and luciferase reporter assay revealed that E2F2 was a direct target of miR-218 in glioma cells. This investigation demonstrated that elevated E2F2 expression could partly weaken the effect of miR-218 in vitro. This study also showed that miR-218 may be a repressor in glioma by directly targeting E2F2, as well as a potential therapeutic target in gliomas. PMID:26012781

  8. miR-218 suppresses tumor growth and enhances the chemosensitivity of esophageal squamous cell carcinoma to cisplatin.

    Science.gov (United States)

    Tian, Hang; Hou, Lei; Xiong, Yu-Mei; Huang, Jun-Xiang; She, Ying-Jun; Bi, Xiao-Bao; Song, Xing-Rong

    2015-02-01

    A growing body of evidence suggests that microRNA-218 (miR-218) acts as a tumor suppressor and is involved in tumor progression, development and metastasis and confers sensitivity to certain chemotherapeutic drugs in several types of cancer. However, our knowledge concerning the exact roles played by miR-218 in esophageal squamous cell carcinoma (ESCC) and the underlying molecular mechanisms remain relatively unclear. Thus, the aims of this study were to detect the expression of miR-218 in human ESCC tissues and explore its effects on the biological features and chemosensitivity to cisplatin (CDDP) in an ESCC cell line (Eca109), so as to provide new insights for ESCC treatment. Here, we found increased expression of miR-218 in the ESCC tissues compared with that in the matched non-tumor tissues, and its expression level was correlated with key pathological characteristics including clinical stage, tumor depth and metastasis. We also found that enforced expression of miR-218 significantly decreased cell proliferation, colony formation, migration and invasion, induced cell apoptosis and arrested the cell cycle in the G0/G1 phase, as well as suppressed tumor growth in a nude mouse model. In addition, our results showed that miR-218 mimics increased the sensitivity to the antitumor effect of CDDP in the human Eca109 cells. Importantly, this study also showed that miR-218 regulated the expression of phosphorylated PI3K, AKT and mTOR, which may contribute to suppressed tumor growth of ESCC and enhanced sensitivity of ESCC cells. These findings suggest that miR-218 is a potential therapeutic agent for the treatment of ESCC.

  9. Transient-diffusion measurements of radon. Fick's law confirmation and 218Po/214Po behavior determination

    International Nuclear Information System (INIS)

    Usually, radon diffusion coefficients in soils are measured based on the assumption that Fick's law holds true. But, unlike in a free volume, strictly speaking, there is no guarantee that Fick's law holds in soils. Transient-diffusion measurements of radon in soils are best employed in order to confirm Fick's law. Alpha-particles from 218Po/214Po and from 222Rn cannot be distinguished in the course of those measurements. Therefore, the relevant portions of the detector reading must be allocated to each of these nuclides. For that purpose, the behaviors of 218Po and 214Po in the detection volume were determined and their ratios of contribution to the detector reading were also determined by Monte Carlo calculations and a verification test. This information was used to confirm Fick's law for representative Japanese sand and loam samples through indicial transient-diffusion measurements and a theoretical interpretation of the measured data. (author)

  10. Synthesis of 2-18F-fluoroisonicotinic acid hydrazide and initial biological evaluation

    International Nuclear Information System (INIS)

    Isonicotinic acid hydrazide (isonizide) is one of the most effective agents in tuberculosis therapy. This agent rapidly permeates the bacterial cell membrane via passive diffusion. The central nervous system tuberculosis is being observed in patients who are intravenous drug abusers, with AIDS and AIDS-related complex. Therefore, radiopharmaceuticals for diagnosis of tuberculosis may become important. Very few attempts have been made to develop isonicotinic acid and derivatives for the same application. As part of an on-going research effort to develop radiotracers for fluorination of proteins and peptides via prosthetic groups approach, we have synthesized ethyl 2-[18F]-fluoroisonicotinate and 2-[18F]-fluoroisonicotinic acid hydrazide. The synthetic approach starts from treatment of ethyl-2-(trimethylammonium)-isonicotinate precursor using no-carrier-added radiofluoride produced by the 18O(p,n)18F nuclear reaction on 18O-enriched (95 %) water and Kryptofix 222 as nucleophilic catalyst in anhydrous acetonitrile at 1000C, gave ethyl 2-[18F]-fluoroisonicotinate in greater than 90% radiochemical yield (decay corrected) within two minutes reaction time. The ether extract of fluorinated ethylester evaporated and residue was re-dissolved in ethanol and treated with hydrazine for 15 minutes in boiling water to obtain 2-[18F]-fluoroisonicotinic acid hydrazide in excellent radiochemical yield. The overall radiochemical yield was greater that 70% with total synthesis time of approximately one hour. This synthetic approach hold considerable promise as a rapid and simple method for fluorination of radiopharmaceuticals of high radiochemical yield. Biological evaluation was performed in normal mice. The data obtained shown that the lungs appear to retain some activity that someone may presume that such radiotracer maybe useful in detection of tuberculosis

  11. China March Apparel Retail Sales Report Retail Sales Vaule + 21.8% Y/Y

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Total retail sales value in major department stores picked up sharply in Mar. 2011, rising by about 25.6 percent y/y to CNY 46.63 billion, according to Na-tion Commercial Information Center of China. Of which, retail sales value of apparel products in major department stores increased 21.8 per cent y/y to CNY 11.89 billion, 3.8% lower than national average. For volume, retail sales volum

  12. An analysis of clinical characteristics,etiologies and prognosis of 218 patients with infective endocarditis

    Institute of Scientific and Technical Information of China (English)

    谢红梅

    2014-01-01

    Objective To describe the profile of patients with infective endocarditis(IE)and assess prognostic factors of IE.Methods Clinical and etiology data of 218 patients with IE were collected retrospectively from January 2011to January 2013.The distribution and antimicrobial susceptibilities of pathogens causing IE were evaluated.Prognostic factors associated with IE were determined by univariate and multivariate regression analysis.Results

  13. Progress of research in miR-218 and cervical cancer

    Institute of Scientific and Technical Information of China (English)

    Kangkang Zeng; Wei Zhang; Xiaoxia Hu

    2013-01-01

    MicroRNAs (miRNAs) are smal endogenous non-coding RNAs which can specifical y silence gene expression, and thereby alter cel and organism phenotype. Deregulation of miRNA expression has been discovered in a variety of tumors and it is now clear that they contribute to cancer development and progression. Previous studies have indicated that miRNAs are involved in developmental timing, cel proliferation, apoptosis, morphogenesis [1], antiviral defense [2], and tumorigenesis [3]. In cancer pathways, altered expression of tumor suppressive or oncogenic miRNAs can disrupt regulatory mechanisms normal. Altered miRNAs expression patterns have been observed in a variety of diseased tissues. Cervical cancer is the most common malignant tumor in female reproductive tract. Recently more and more study showed a large number of miRNAs were down-regulated or up-regulated in cervical cancer. Recent data revealed that miRNA-218 (miR-218) played important roles in tumor initiation and development. This review focuses on analysis of miR-218 and wil provide some insight into the progress of cervical cancer.

  14. 老年贫血218例病因分析%Etiopathogenisis analysis of 218 cases of anemia in the elderly

    Institute of Scientific and Technical Information of China (English)

    高丽霞; 吴克雄; 冀红红; 谢静荣

    2010-01-01

    目的 探讨老年贫血的诊断特点.方法 分析218例老年贫血病例的血常规、骨髓红系增生情况、骨髓形态学及病理学诊断、病因诊断等项目为观察指标.结果 218例老年贫血病例中,男性数量稍多于女性,中位年龄67.9岁.中重度贫血占绝大多数,形态学上以小细胞性贫血比例最高,占42.66%;其次为正细胞性贫血,占35.85%.骨髓红系增生活跃以上者占82.35%;缺铁性贫血为老年贫血最常见的病种(39.44%),其次为巨幼细胞性贫血、骨髓增生异常综合征.缺铁性贫血的病因中摄入不足最常见,占25.66%,肿瘤、溃疡及胃大部切除术后也较多见.骨髓增生异常综合征、巨幼细胞性贫血和慢性再生障碍性贫血为老年全血细胞减少病例的常见病种.结论 老年人属弱势群体,老年贫血病例中缺铁性贫血和营养不良性贫血比例高.%Objective To explore the diagnostic characteristics of anemia in the elderly. Methods To measure and analyze the eric status of bone marrow, diagnosis according to morphology and biopsy of bone marrow, and etiology of anemia(IDA) in 218 cases of anemia in the aged. Results In these 218 cases male patients were slightly more than female patients. Median age was 68.9. Ratio of cases with macrocytic anemia was the highest(42.66%), ratio of cases with active erythropoietic status was 82. 35%. Iron deficiency anemia was the most common anemia in the elderly(39. 44%), and megaloblastic anemia and myelodysplastic syndrome (MDS) were also frequent. Insufficient ingestion was the most common cause of IDA(25.66 %),and tumors,digestive ulcers and postgastrectomy were also the common causes. MDS,megaloblastic anemia and chronic aplastic anemia(CAA) were the common anemia in geriatric population with pancytopenia. Conclusions Geriatric population is the fragile group. Ratio of cases with anemia due to IDA and malnutrition is high in cases of anemia in the elderly.

  15. Analysis of 218 cases of children's ADR reports%218例儿童药品不良反应报告分析

    Institute of Scientific and Technical Information of China (English)

    董传婷; 赵孝林; 郝丽娜

    2014-01-01

    目的:分析笔者所在医院儿童药品不良反应( ADR)的发生特点及影响因素,保障儿童用药安全。方法采用回顾性分析法,对218例儿童ADR报告按照报告类型、患儿年龄、性别、体质量,药品种类、给药途径,临床表现等进行统计分析。结果218例ADR报告中,患儿的平均年龄为(2.99±2.89)岁,平均体质量为(14.18±8.51) kg,男女比例为1.32:1,0~3岁患儿占58.26%;新的和严重的ADR占33.03%;引发ADR最多的是抗微生物药,占67.89%;最主要的给药方式是静脉滴注,占92.20%;ADR累及器官或系统中皮肤及其附件与全身性占80.76%。结论为使儿童ADR监测工作得到持续改进,医院必须有重点的继续加强培训,增强行政监管力度,加大奖惩力度,加强药品的质量控制,临床上继续减少静脉给药频率,加强用药监护,做好急救措施。%Objective To analyze the characters and influencing factors of children ADR monitoring in our hospital, and ensure the medical safety for children. Methods Retrospective study was used to analyze 218 cases of children ADR reports statistically in 2012,in accordance with the type of report and children′s age,gender,weight,as well as drug types, routes of administration,clinical manifestation etc. Results In the 218 cases of ADR reports,the children′s average age was(2. 99 ± 2. 89)years,the average weight was(14. 18 ± 8. 51)kg,male to female ratio was 1. 32:1,children of 0~3 years old accounted for 58. 26%;new and severe ADR accounted for 33. 03%;most of the ADR was caused by antimicrobi-al drugs,which accounted for 67. 89%;intravenous infusion,the main route of administration,accounted for 92. 20%;ADR involving the skin and its appendages as well as systemic accounted for 80. 76%. Conclusion In order to get continuous improvement in children ADR monitoring,the hospital must continue to focus on enhancing training,and strengthening ad

  16. Motor neuron-expressed microRNAs 218 and their enhancers are nested within introns of Slit2/3 genes.

    Science.gov (United States)

    Punnamoottil, Beena; Rinkwitz, Silke; Giacomotto, Jean; Svahn, Adam J; Becker, Thomas S

    2015-05-01

    miR218-1 and miR218-2 are embedded in introns of SLIT2 and SLIT3, respectively, an arrangement conserved throughout vertebrate genomes. Both miR218 genes are predicted to be transcribed in the same orientation as their host genes and were assumed to be spliced from Slit2/3 primary transcripts. In zebrafish miR218 is active in cranial nerve motor nuclei and spinal cord motor neurons, while slit2 and slit3 are expressed predominantly in the midline. This differential expression pattern suggested independent regulation of miR218 genes by distinct enhancers. We tested conserved noncoding elements for regulatory activity by reporter gene transgenesis in zebrafish. Two human enhancers, 76 kb and 130 kb distant from miR218-2, were identified that drove GFP expression in zebrafish in an almost complete miR218 expression pattern. In the zebrafish slit3 locus, two enhancers with identical activity were discovered. In human SLIT2 one enhancer 52 kb upstream of miR218-1 drove an expression pattern very similar to the enhancers of miR218-2. This establishes that miR218-1/-2 regulatory units are nested within SLIT2/3 and that they are duplicates of an ancestral single locus. Due to the strong activity of the enhancers, unique transgenic lines were created that facilitate morphological and gene functional genetic experiments in motor neurons.

  17. Production process validation of 2-[18F]-fluoro-2-deoxy-D-glucose

    International Nuclear Information System (INIS)

    The main of validation of production process of 2-[18F]-fluoro-2-deoxi-D-glucose (FDG) was to check: A) equipment's and services implicated in the production process were correctly installed, well documented, and worked properly, and B) production of FDG was done in a repetitive way according to predefined parameters. The main document was the Validation Master Plan, and steps were: installation qualification, operation qualification, process qualification and validation report. After finalization of all tests established in qualification steps without deviations, we concluded that the production process was validated because is done in a repetitive way according predefined parameters (Au)

  18. MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma.

    Directory of Open Access Journals (Sweden)

    Morgan R Davidson

    Full Text Available MicroRNAs (miRNAs are a family of small, non-coding RNA species functioning as negative regulators of multiple target genes including tumour suppressor genes and oncogenes. Many miRNA gene loci are located within cancer-associated genomic regions. To identify potential new amplified oncogenic and/or deleted tumour suppressing miRNAs in lung cancer, we inferred miRNA gene dosage from high dimensional arrayCGH data. From miRBase v9.0 (http://microrna.sanger.ac.uk, 474 human miRNA genes were physically mapped to regions of chromosomal loss or gain identified from a high-resolution genome-wide arrayCGH study of 132 primary non-small cell lung cancers (NSCLCs (a training set of 60 squamous cell carcinomas and 72 adenocarcinomas. MiRNAs were selected as candidates if their immediately flanking probes or host gene were deleted or amplified in at least 25% of primary tumours using both Analysis of Copy Errors algorithm and fold change (≥ ± 1.2 analyses. Using these criteria, 97 miRNAs mapped to regions of aberrant copy number. Analysis of three independent published lung cancer arrayCGH datasets confirmed that 22 of these miRNA loci showed directionally concordant copy number variation. MiR-218, encoded on 4p15.31 and 5q35.1 within two host genes (SLIT2 and SLIT3, in a region of copy number loss, was selected as a priority candidate for follow-up as it is reported as underexpressed in lung cancer. We confirmed decreased expression of mature miR-218 and its host genes by qRT-PCR in 39 NSCLCs relative to normal lung tissue. This downregulation of miR-218 was found to be associated with a history of cigarette smoking, but not human papilloma virus. Thus, we show for the first time that putative lung cancer-associated miRNAs can be identified from genome-wide arrayCGH datasets using a bioinformatics mapping approach, and report that miR-218 is a strong candidate tumour suppressing miRNA potentially involved in lung cancer.

  19. ADAM9 up-regulates N-cadherin via miR-218 suppression in lung adenocarcinoma cells.

    Directory of Open Access Journals (Sweden)

    Yuh-Pyng Sher

    Full Text Available Lung cancer is the leading cause of cancer death worldwide, and brain metastasis is a major cause of morbidity and mortality in lung cancer. CDH2 (N-cadherin, a mesenchymal marker of the epithelial-mesenchymal transition and ADAM9 (a type I transmembrane protein are related to lung cancer brain metastasis; however, it is unclear how they interact to mediate this metastasis. Because microRNAs regulate many biological functions and disease processes (e.g., cancer by down-regulating their target genes, microRNA microarrays were used to identify ADAM9-regulated miRNAs that target CDH2 in aggressive lung cancer cells. Luciferase assays and western blot analysis showed that CDH2 is a target gene of miR-218. MiR-218 was generated from pri-mir-218-1, which is located in SLIT2, in non-invasive lung adenocarcinoma cells, whereas its expression was inhibited in aggressive lung adenocarcinoma. The down-regulation of ADAM9 up-regulated SLIT2 and miR-218, thus down-regulating CDH2 expression. This study revealed that ADAM9 activates CDH2 through the release of miR-218 inhibition on CDH2 in lung adenocarcinoma.

  20. IC-218合金的再结晶织构及其形成机制%RECRYSTALLIZATION TEXTURE OF IC-218 ALLOY

    Institute of Scientific and Technical Information of China (English)

    林一坚

    2004-01-01

    研究了IC-218合金冷轧60%后在1000℃退火中形成的织构,发现再结晶后晶粒取向分布漫散,这种情况早在再结晶形核阶段就已出现,并在随后的长时间退火中保持.相继出现几个弱的再结晶织构,它们都与冷轧织构之间存在与低∑重合点阵相近的位向关系.这些结果可与显微组织的观察很好地相互印证,表明导致再结晶织构这些特点的基本原因是一般大角晶界失去明显可动性而以位错运动为机制的界面迁移则相对活跃.将以上结果与单相Ni3Al的再结晶行为进行对比,发现两者极为相似.由此对76Ni-24Al-0.24B合金的晶界结构是否存在无序区的问题提供了新的信息.

  1. H_2^{16}O and H_2^{18}O Maser Emission from Gas-Dust Clouds

    CERN Document Server

    Nesterenok, Aleksandr; 10.1134/S1063773711070036

    2011-01-01

    The collisional pumping of H_2^{16}O and H_2^{18}O masers in hot dense gas-dust clouds has been simulated numerically. New data on the rate coefficients for collisional transitions from Faure et al. (2007) were used in the calculations. The possibility of detecting H_2^{18}O emission in 22.2-GHz H_2^{16}O maser sources is investigated. The medium is shown to become optically thick in the H_2^{16}O lines for which an inverted level population is observed at H_2O column densities of ~10^{19}-10^{20} cm^{-2}. A simultaneous observation of H_2^{18}O emission and H_2^{16}O maser emission in the same source will allow the physical conditions in the gas-dust cloud to be refined.

  2. Numerical modeling of Po-218 deposition in a physiologically realistic lung bifurcation model

    Science.gov (United States)

    Mously-Soroujy, Khalid Ahmad

    Experimental data for lung bifurcations reveals complex geometries and distinct asymmetrical characteristic, which affects the localized distribution of particles deposited in the lung. This study is based on recently published numerical results for a symmetric physiological realistic bifurcation geometry Heistracher and Hofmann (1995) which has been extended here to the case of a asymmetric geometry. The asymmetric PRB model was used to study the flow field and the deposition of ultrafine particles for inspiratory and expiratory conditions. In the present study, we investigated the effect of different flow rates, representing human activity and deposition of different ultrafine particles representing radon daughter (Po-218), in the PRB model. Numerical results were compared with the limited available experimental and numerical data. The fluid dynamic computer program FIDAP was used for this purpose.

  3. Malignant transformation of oral leukoplakia: a retrospective cohort study of 218 Chinese patients

    International Nuclear Information System (INIS)

    Oral leukoplakia (OL) is the best-known potentially malignant disorder. A new binary system to grade dysplasia was proposed by WHO, but the biological significance in predicting malignant transformation risk is unknown. The objective of this study is to estimate the rate of malignant transformation in a long-term follow-up cohort, explore the usefulness of the new binary system of grading dysplasia and identify significant risk factors of OL malignant transformation in China. A total of 218 patients with clinical and histopathologic diagnosis of OL were retrospectively reviewed. They were selected among all archived files at the Department of Oral Mucosal Diseases, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. The mean follow-up period was 5.3 years. Among 218 cases, 39 (17.9%) OL patients developed oral cancer, with a mean duration of 5.2 years. Cox regression analysis revealed that dysplasia was an independent risk factor for OL malignant transformation, but age, gender, lesion site, diet habit, smoking and ethanol intake were not risk factors. High-risk dysplastic OL was associated with a 4.57-fold (95% confidence interval, 2.36-8.84; P < 0.001) increased risk of malignant transformation, compared with low-risk dysplasia. Consistent with this result, high-risk dysplastic OL had signicantly higher malignant incidence than low-risk dysplasia, particularly during the first 2-3 years of follow-up, by Kaplan-Meier analysis (Log-rank test, P < 0.001). The new binary system's function in predicting OL malignant transformation risk was investigated in this survey. The utilization of high-risk dysplasia as a significant indicator for evaluating malignant transformation risk in patients with OL was suggested, which may be helpful to guide treatment selection in clinical practice

  4. 5 CFR 792.218 - Does the law apply only to on-site Federal child care centers that are utilized by Federal families?

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Does the law apply only to on-site Federal child care centers that are utilized by Federal families? 792.218 Section 792.218 Administrative... law apply only to on-site Federal child care centers that are utilized by Federal families? The...

  5. Cooked oatmeal consumption is associated with better diet quality, better nutrient intakes, and reduced risk for central adiposity and obesity in Children 2-18 years

    Science.gov (United States)

    The objective of this study was to assess the association between oatmeal consumption and nutrient intake, diet quality, and weight/adiposity of children aged 2-18. A nationally representative sample of children aged 2-18 (N=14,690) participating in National Health and Nutrition Examination Survey 2...

  6. Uptake and tracer kinetics of O-(2-(18)F-fluoroethyl)-L-tyrosine in meningiomas : preliminary results

    NARCIS (Netherlands)

    Cornelius, Jan F; Stoffels, Gabriele; Filß, Christian; Galldiks, Norbert; Slotty, Philipp; Kamp, Marcel; el Khatib, Mustafa; Hänggi, Daniel; Sabel, Michael; Felsberg, Jörg; Steiger, Hans Jakob; Coenen, Heinz H; Shah, Nadim J; Langen, Karl-Josef

    2015-01-01

    PURPOSE: O-(2-[(18)F]Fluoroethyl)-L-tyrosine ((18)F-FET) is a well-established PET tracer for the imaging of cerebral gliomas, but little is known about (18)F-FET uptake in meningiomas. The aim of this study was to explore (18)F-FET kinetics and tumour-to-background contrast in meningiomas of variou

  7. Spitzer Observations Confirm and Rescue the Habitable-Zone Super-Earth K2-18b for Future Characterization

    CERN Document Server

    Benneke, Björn; Petigura, Erik; Knutson, Heather; Dressing, Courtney; Crossfield, Ian J M; Schlieder, Joshua E; Livingston, John; Beichman, Charles; Christiansen, Jessie; Krick, Jessica; Gorjian, Varoujan; Howard, Andrew W; Sinukoff, Evan; Ciardi, David R; Akeson, Rachel L

    2016-01-01

    The recent detections of two transit events attributed to the super-Earth candidate K2-18b have provided the unprecedented prospect of spectroscopically studying a habitable-zone planet outside the Solar System. Orbiting a nearby M2.5 dwarf and receiving virtually the same stellar insolation as Earth, K2-18b would be a prime candidate for the first detailed atmospheric characterization of a habitable-zone exoplanet using HST and JWST. Here, we report the detection of a third transit of K2-18b near the predicted transit time using the Spitzer Space Telescope. The Spitzer detection demonstrates the periodic nature of the two transit events discovered by K2, confirming that K2-18 is indeed orbited by a super-Earth in a 33-day orbit and ruling out the alternative scenario of two similarly-sized, long-period planets transiting only once within the 75-day K2 observation. We also find, however, that the transit event detected by Spitzer occurred 1.85 hours (7-sigma) before the predicted transit time. Our joint analy...

  8. Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutation

    NARCIS (Netherlands)

    Stam, A. H.; Luijckx, G-J; Poll-The, B. T.; Ginjaar, I. B.; Frants, R. R.; Haan, J.; Ferrari, M. D.; Terwindt, G. M.; van den Maagdenberg, A. M. J. M.

    2009-01-01

    Objective: To study the clinical spectrum of CACNA1A S218L mutation carriers with special attention to "early seizures and cerebral oedema after trivial head trauma (ESCEATHT)", a combination of symptoms which resembles the "juvenile head trauma syndrome". Patients and methods: In two patients with

  9. Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutation

    NARCIS (Netherlands)

    A.H. Stam; G.J. Luijckx; B.T. Poll-Thé; I.B. Ginjaar; R.R. Frants; J. Haan; M.D. Ferrari; G.M. Terwindt; A.M.J.M. van den Maagdenberg

    2009-01-01

    OBJECTIVE: To study the clinical spectrum of CACNA1A S218L mutation carriers with special attention to "early seizures and cerebral oedema after trivial head trauma (ESCEATHT)", a combination of symptoms which resembles the "juvenile head trauma syndrome". PATIENTS AND METHODS: In two patients with

  10. MicroRNA 218 mediates the effects of Tbx5a over-expression on zebrafish heart development.

    Directory of Open Access Journals (Sweden)

    Elena Chiavacci

    Full Text Available tbx5, a member of the T-box gene family, encodes one of the key transcription factors mediating vertebrate heart development. Tbx5 function in heart development appears to be exquisitely sensitive to gene dosage, since both haploinsufficiency and gene duplication generate the cardiac abnormalities associated with Holt-Oram syndrome (HOS, a highly penetrant autosomal dominant disease characterized by congenital heart defects of varying severity and upper limb malformation. It is suggested that tight integration of microRNAs and transcription factors into the cardiac genetic circuitry provides a rich and robust array of regulatory interactions to control cardiac gene expression. Based on these considerations, we performed an in silico screening to identify microRNAs embedded in genes highly sensitive to Tbx5 dosage. Among the identified microRNAs, we focused our attention on miR-218-1 that, together with its host gene, slit2, is involved in heart development. We found correlated expression of tbx5 and miR-218 during cardiomyocyte differentiation of mouse P19CL6 cells. In zebrafish embryos, we show that both Tbx5 and miR-218 dysregulation have a severe impact on heart development, affecting early heart morphogenesis. Interestingly, down-regulation of miR-218 is able to rescue the heart defects generated by tbx5 over-expression supporting the notion that miR-218 is a crucial mediator of Tbx5 in heart development and suggesting its possible involvement in the onset of heart malformations.

  11. Synthesis and biological evaluation of anti-1-amino-2-[18F]fluoro-cyclobutyl-1-carboxylic acid (anti-2-[18F]FACBC) in rat 9L gliosarcoma.

    Science.gov (United States)

    Yu, Weiping; Williams, Larry; Camp, Vernon M; Olson, Jeffrey J; Goodman, Mark M

    2010-04-01

    A new [(18)F] labeled amino acid anti-1-amino-2-[(18)F]fluoro-cyclobutyl-1-carboxylic acid 9 (anti-2-[(18)F]FACBC) was synthesized in 30% decay-corrected yield with high radiochemical purity over 99%. The cyclic sulfamidate precursor was very stable and highly reactive towards nucleophilic radiofluorination. Cell uptake assays with rat 9L gliosarcoma cells showed that [(18)F]9 was transported into tumor cells via multiple amino acid transport systems, including L and A systems. Biodistribution study in rats with intracranial 9L gliosarcoma tumors demonstrated that [(18)F]9 had a rapid and prolonged accumulation in tumors with 26:1 tumor to brain ratio at 120 min post-injection. In this model, [(18)F]9 is a potential PET tracer for brain tumor imaging.

  12. Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma.

    Science.gov (United States)

    Kinoshita, Takashi; Hanazawa, Toyoyuki; Nohata, Nijiro; Kikkawa, Naoko; Enokida, Hideki; Yoshino, Hirofumi; Yamasaki, Takeshi; Hidaka, Hideo; Nakagawa, Masayuki; Okamoto, Yoshitaka; Seki, Naohiko

    2012-11-01

    Recent our microRNA (miRNA) expression signature revealed that expression of microRNA-218 (miR-218) was reduced in cancer tissues, suggesting a candidate of tumor suppressor in head and neck squamous cell carcinoma (HNSCC). The aim of this study was to investigate the functional significance of miR-218 and its mediated moleculer pathways in HNSCC. Restoration of miR-218 in cancer cells led to significant inhibition of cell migration and invasion activities in HNSCC cell lines (FaDu and SAS). Genome-wide gene expression analysis of miR-218 transfectants and in silico database analysis showed that focal adhesion pathway was a promising candidate of miR-218 target pathways. The laminins are an important and biologically active part of the basal lamina, the function of that are various such as influencing cell differentiation, migration and adhesion as well as proliferation and cell survival. Interestingly, all components of laminin-332 (LAMA3, LAMB3 and LAMC2) are listed on the candidate genes in focal adhesion pathway. Furthermore, we focused on LAMB3 which has a miR-218 target site and gene expression studies and luciferase reporter assays showed that LAMB3 was directly regulated by miR-218. Silencing study of LAMB3 demonstrated significant inhibition of cell migration and invasion. In clinical specimens with HNSCC, the expression levels of laminin-332 were significantly upregulated in cancer tissues compared to adjacent non-cancerous tissues. Our analysis data showed that tumor suppressive miR-218 contributes to cancer cell migration and invasion through regulating focal adhesion pathway, especially laminin-332. Tumor suppressive miRNA-mediated novel cancer pathways provide new insights into the potential mechanisms of HNSCC oncogenesis. PMID:23159910

  13. A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish.

    Science.gov (United States)

    Fish, Jason E; Wythe, Joshua D; Xiao, Tong; Bruneau, Benoit G; Stainier, Didier Y R; Srivastava, Deepak; Woo, Stephanie

    2011-04-01

    Members of the Slit family of secreted ligands interact with Roundabout (Robo) receptors to provide guidance cues for many cell types. For example, Slit/Robo signaling elicits repulsion of axons during neural development, whereas in endothelial cells this pathway inhibits or promotes angiogenesis depending on the cellular context. Here, we show that miR-218 is intronically encoded in slit2 and slit3 and that it suppresses Robo1 and Robo2 expression. Our data indicate that miR-218 and multiple Slit/Robo signaling components are required for heart tube formation in zebrafish and that this network modulates the previously unappreciated function of Vegf signaling in this process. These findings suggest a new paradigm for microRNA-based control of ligand-receptor interactions and provide evidence for a novel signaling pathway regulating vertebrate heart tube assembly.

  14. LED-based Fourier transform spectroscopy of H218O in the 15,000-16,000 cm-1 range

    Science.gov (United States)

    Mikhailenko, S. N.; Serdyukov, V. I.; Sinitsa, L. N.

    2015-05-01

    The spectrum of Н218О has been recorded between 15,000 and 16,000 cm-1 by a Fourier transform spectrometer with spectral resolutions of 0.03 cm-1 and 0.05 cm-1 using high luminance LED light sources and a 60-cm multipath cell with a path length of 1920 and 3480 cm. A high signal-to-noise ratio (S/N=10,000) enabled us to register more than 1500 water vapor lines with intensities 1.0×10-27 to 2.2×10-24 cm/molecule at 296 K. 426 rotational-vibrational levels of the H218O molecule were assigned to eleven vibrational states: (014), (033), (052), (113), (132), (151), (212), (231), (311), (330) and (410). 72 Rotational-vibrational levels of the H217O molecule were assigned to six vibrational states: (014), (033), (113), (212), (311) and (410). An extended set of H218O transitions in the 15,000-16,000 cm-1 range was generated using the obtained energy level list and the results of a variational intensity calculation.

  15. Synthesis of 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine as a radioligand for imaging nicotinic acetylcholine receptors

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Nicotinic acetylcholine receptors (nChRs) are involved in the variouspharmacological effects or disease states. In order to study the central nChRs by PETor SPECT, some radioligands have been investigated. In this paper, the procedurefor synthesis of 2-[18F]fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine (2-[18F]-A-85380), apotential PET ligand for in vivo imaging nicotinic acetylcholine receptor was described.2-[18F]-A-85380 was prepared from the precursor, 2-nitro-3-[(1-(tert-butoxycarbonyl)-2-(S)-azetidinyl)methoxy]pyridine(4), which was synthesized with commercial (S)-2-azetid- inecarboxylic acid as starting material. The whole procedure for radiosynthesisand purification was executed in about lh and 45-55% of the added fluorine-18 wasfound in the purified 2-[18F]-A-85380, with specific activity of 1.0-2.2 × 1011 Bq/μmol.``

  16. SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung's disease.

    Science.gov (United States)

    Tang, Weibing; Tang, Junwei; He, Jun; Zhou, Zhigang; Qin, Yufeng; Qin, Jingjing; Li, Bo; Xu, Xiaoqun; Geng, Qiming; Jiang, Weiwei; Wu, Wei; Wang, Xinru; Xia, Yankai

    2015-06-01

    Hirschsprung's disease (HSCR) is a rare congenital disease caused by impaired proliferation and migration of neural crest cells. We investigated changes in expression of microRNAs (miRNAs) and the genes they regulate in tissues of patients with HSCR. Quantitative real-time PCR and immunoblot analyses were used to measure levels of miRNA, mRNAs, and proteins in colon tissues from 69 patients with HSCR and 49 individuals without HSCR (controls). Direct interactions between miRNAs and specific mRNAs were indentified in vitro, while the function role of miR-218-1 was investigated by using miR-218 transgenic mice. An increased level of miR-218-1 correlated with increased levels of SLIT2 and decreased levels of RET and PLAG1 mRNA and protein. The reductions in RET and PLAG1 by miR-218-1 reduced proliferation and migration of SH-SY5Y cells. Overexpression of the secreted form of SLIT2 inhibited cell migration via binding to its receptor ROBO1. Bowel tissues from miR-218-1 transgenic mice had nerve fibre hyperplasia and reduced numbers of gangliocytes, compared with wild-type mice. Altered miR-218-1 regulation of SLIT2, RET and PLAG1 might be involved in the pathogenesis of HSCR.

  17. MnBr2/18-crown-6 coordination complexes showing high room temperature luminescence and quantum yield.

    Science.gov (United States)

    Hausmann, David; Kuzmanoski, Ana; Feldmann, Claus

    2016-04-12

    The reaction of manganese(ii) bromide and the crown ether 18-crown-6 in the ionic liquid [(n-Bu)3MeN][N(Tf)2] under mild conditions (80-130 °C) resulted in the formation of three different coordination compounds: MnBr2(18-crown-6) (), Mn3Br6(18-crown-6)2 () and Mn3Br6(18-crown-6) (). In general, the local coordination and the crystal structure of all compounds are driven by the mismatch between the small radius of the Mn(2+) cation (83 pm) and the ring opening of 18-crown-6 as a chelating ligand (about 300 pm). This improper situation leads to different types of coordination and bonding. MnBr2(18-crown-6) represents a molecular compound with Mn(2+) coordinated by two bromine atoms and only five oxygen atoms of 18-crown-6. Mn3Br6(18-crown-6)2 falls into a [MnBr(18-crown-6)](+) cation - with Mn(2+) coordinated by six oxygen atoms and Br - and a [MnBr(18-crown-6)MnBr4](-) anion. In this anion, Mn(2+) is coordinated by five oxygen atoms of the crown ether as well as by two bromine atoms, one of them bridging to an isolated (MnBr4) tetrahedron. Mn3Br6(18-crown-6), finally, forms an infinite, non-charged [Mn2(18-crown-6)(MnBr6)] chain. Herein, 18-crown-6 is exocyclically coordinated by two Mn(2+) cations. All compounds show intense luminescence in the yellow to red spectral range and exhibit remarkable quantum yields of 70% (Mn3Br6(18-crown-6)) and 98% (Mn3Br6(18-crown-6)2). The excellent quantum yield of Mn3Br6(18-crown-6)2 and its differentiation from MnBr2(18-crown-6) and Mn3Br6(18-crown-6) can be directly correlated to the local coordination. PMID:26956783

  18. 218例幼年特发性关节炎血液系统的临床表现

    Institute of Scientific and Technical Information of China (English)

    覃肇源; 徐明; 黄婷婷; 丘小汕; 陈志凤; 刘关娜

    2005-01-01

    幼年特发性关节炎(juvenile idiopathic arthritis,JLA)是儿童常见的结缔组织病之一,常合并慢性病贫血(anemia of chronic disease,ACD)或称炎症性贫血(inflamatory anemia)。1994年6月~2004年8月,我科收住了218例JIA,乃回顾分析本病在血液系统的异常临床表现及实验室检查,以加深JLA导致ACD的认识。

  19. The First Circumstellar Disk Imaged in Silhouette with Adaptive Optics: MagAO Imaging of Orion 218-354

    CERN Document Server

    Follette, Katherine B; Males, Jared R; Kopon, Derek; Wu, Ya-Lin; Morzinski, Katie M; Hinz, Philip; Rodigas, Timothy J; Puglisi, Alfio; Esposito, Simone; Riccardi, Armando; Pinna, Enrico; Xompero, Marco; Briguglio, Runa

    2013-01-01

    We present high resolution adaptive optics (AO) corrected images of the silhouette disk Orion 218-354 taken with Magellan AO (MagAO) and its visible light camera, VisAO, in simultaneous differential imaging (SDI) mode at H-alpha. This is the first image of a circumstellar disk seen in silhouette with adaptive optics and is among the first visible light adaptive optics results in the literature. We derive the disk extent, geometry, intensity and extinction profiles and find, in contrast with previous work, that the disk is likely optically-thin at H-alpha. Our data provide an estimate of the column density in primitive, ISM-like grains as a function of radius in the disk. We estimate that only ~10% of the total sub-mm derived disk mass lies in primitive, unprocessed grains. We use our data, Monte Carlo radiative transfer modeling and previous results from the literature to make the first self-consistent multiwavelength model of Orion 218-354. We find that we are able to reproduce the 1-1000micron SED with a ~2...

  20. Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes.

    Science.gov (United States)

    Kim, Mirang; Kim, Jong-Hwan; Baek, Su-Jin; Kim, Seon-Young; Kim, Yong Sung

    2016-06-01

    SLIT has been suggested as a key regulator of cancer development and a promising therapeutic target for cancer treatment. Herein, we analyzed expression and methylation of SLIT1/SLIT2/SLIT3 in 11 gastric cancer cell lines, 96 paired gastric tumors and adjacent normal gastric tissues, and 250 gastric cancers provided by The Cancer Genome Atlas. Methylation of SLIT1/SLIT2/SLIT3 was found both in early gastric cancers, and in advanced gastric cancers. Even normal gastric tissue showed increased methylation of SLIT1 and SLIT3 that correlated with patient age. Furthermore, epigenetic inactivation of SLIT occurred in a gastric cancer subtype-dependent manner. SLIT2 and SLIT3 expression was reduced in Epstein-Barr virus-positive and microsatellite instability subtypes, but increased in the genomically stable subtype. Expression of miR‑218 correlated negatively with methylation of SLIT2 or SLIT3. These findings suggest that a molecular subtype-specific therapeutic strategy is needed for targeting SLITs and miR-218 in treatment of gastric cancer.

  1. 节能BCD-248/H、BCD-218/H电冰箱的研究开发%Research and development the super energy- saving fridge BCD-218/H and BCD-248/H

    Institute of Scientific and Technical Information of China (English)

    赵先美

    2002-01-01

    运用项目管理方法及ERA电冰箱分析设计软件来科学决策BCD-248/H、BCD-218/H超级节能冰箱的开发设计方案,对采用压缩机、发泡层厚度、门封结构、门一体发泡、电子温控及数显、采用二位三通电磁阀及制冷系统最优化设计等进行了详细的经济技术分析,根据成本与性能综合最优化原则确定了上述两种冰箱的开发设计方案,据此开发出的样机总体能效水平处于国内领先水平.

  2. Asociation between hydroxylase gene A218C polymorphism and anger started as well as anger control trait%TPH基因A218C多态性与愤怒启动及控制特质的关系

    Institute of Scientific and Technical Information of China (English)

    侯俊林; 詹向红; 刘永; 闫秀娟; 闫国立; 李伟; 刘胜利; 王淑玲

    2012-01-01

    Objective: To discuss the association of tryptophan hydroxylase gene A218C polymorphism and anger started as well as anger control trait. Methods: After the subjects were selected by STAXI-2 questionnaire, blood of them was sampled, DNA was extracted by phenol-chloroform method, genotyped by PCR-LDR method, and data was statistically analyzed. Results: ①For high trait anger subjects, there was statistical significance of the scores of anger control-out( AC-O) of male in three genotype groups(P<0.05). ②For low trait anger subjects,there was statistical significance of the following scores of the subjects hi three genotype groups(P<0.05): anger control(AC), anger control-out(AC-0). anger control-in(AC-I) and anger control-out of female(AC-0). Conclusion: There was the association of TPH gene A218C polymorphism with anger control-out trait of normal male college students with high trait anger in China. The locus polymorphism was also related to the following anger traits of normal college students with low trait anger in China: anger control trait, anger control-out trait, anger control-in trait,anger control-out trait of female.%目的:探讨TPH基因A218C多态性与愤怒启动及控制特质的关系.方法:采用状态-特质愤怒表达量表2( STAXI-2)筛选被试,经采血、酚-氯仿法提取DNA、PCR-LDR法基因分型后,对数据进行统计分析.结果:①高特质怒被试3个基因型组男性控制发怒(AC-O)得分差异有统计学意义(P<0.05).②低特质怒被试3个基因型组以下得分差异有统计学意义(P<0.05):怒的控制(AC),控制发怒(AC-O),控制郁怒(AC-I),女性控制发怒(AC-O).结论:TPH基因A218C多态性与我国正常大学生中高特质怒男性的控制发怒特质有关,还与我国正常大学生中低特质怒者怒的控制特质、控制发怒特质、控制郁怒特质及低特质怒女性的控制发怒特质有关.

  3. Radiation and chemical stability of 2-deoxy-2-[18F]fluoro-D-glucose radiopharmaceutical. Author-review of thesis

    International Nuclear Information System (INIS)

    A qualitative and quantitative analytical technique of low-molecular components of chemical and radiation-chemical decomposition of 2-deoxy-2-[18F]fluoro-D-glucose, 2-[18F]FDG radiopharmaceutical was developed for its extended quality control by HPLC with mass-spectrometric electro-spray ionisation detector (ESI MS). The analysis constituted from the liquid chromatography on silica gel NH2 bonded column combined with mass-spectrometric, UV-VIS, refraction index and radiometric detectors. A modern LC/MS system (Agilent 1100) was demonstrated to be suitable not only for identification of unknown analytes, but also for complex analysis of solutes except [18F]F-. This was advantageous for the 2-[18F]FDG autoradiolysis assessment about which no data were published. For comparative purposes, were used a classic thin layer chromatography (TLC) on silica gel with mobile phase acetonitril: water at 95:5 v/v, and HPTLC on NH2 modified silica gel like the LC column. Mobile phase was identical as by LC/MS method (acetonitril: 4 mM aqueous solution of ammonium formate 80:20 v/v). Retention times of reference samples: fluorodeoxyglucose, glucose, mannose, arabinose, deoxyglucose, gluconic and glucuronic acids at HPLC were established. Optimal performance of the ESI MS detector was discovered in negative ions mode or single ion monitoring (SIM) regime. The most intensive signal was observed for all analyte molecules association with formate anion HCOO- and also for negative ions of deprotonised molecules. All acids appeared in the form of their lactones. FDG and Glc exhibited tendency for formation of a mixed associate charged by HCOO- anion. On the amine bond silica gel HPTLC column, FDG is poorly separated from fluoride, which even in presence of Kryptofix 2.2.2 remains on the start like on the silica gel layer. At LC-MS Kryptofix provides a very well measurable signals of associates with NH4+ a H+ ions in positive mode of ESI MS. Concentration of (19F)FDG carrier in 2-[18F

  4. Environmental assessment for Trench 33 widening in 218-W-5 Low-Level Burial Ground, Hanford Site, Richland, Washington

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    This environmental assessment (EA) has been prepared to assess potential environmental impacts associated with the US Department of Energy`s proposed action: to widen and operated the unused Trench 33 in the 218-W-5 Low-Level Burial Ground. Information contained herein will be used by the US Department of Energy, Richland Operations Office Manager, to determine if the Proposed Action is a major federal action significantly affecting the quality of the human environment. If the Proposed Action is determined to be major and significant, an environmental impact statement will be prepared. If the Proposed Action is determined not to be major and significant, a Finding of No significant Impact will be issued and the action may proceed.

  5. Microwave Absorption Properties of Ni-Foped SiC Powders in the 2-18 GHz Frequency Range

    Science.gov (United States)

    Jin, Hai-Bo; Li, Dan; Cao, Mao-Sheng; Dou, Yan-Kun; Chen, Tao; Wen, Bo; Simeon, Agathopoulos

    2011-03-01

    Ni-doped SiC powder with improved dielectric and microwave absorption properties was prepared by self-propagating high-temperature synthesis (SHS). The XRD analysis of the as-synthesized powders suggests that Ni is accommodated in the sites of Si in the lattice of SiC, which shrinks in the presence of Ni. The experimental results show an improvement in the dielectric properties of the Ni-doped SiC powder in the frequency range of 2-18 GHz. The bandwidth of the reflection loss below -10 dB is broadened from 3.04 (for pure SiC) to 4.56 GHz (for Ni-doped SiC), as well as the maximum reflection loss of produced powders from 13.34 to 22.57 dB, indicating that Ni-doped SiC could be used as an effective microwave absorption material.

  6. Microwave Absorption Properties of Ni-Foped SiC Powders in the 2-18 GHz Frequency Range

    Institute of Scientific and Technical Information of China (English)

    JIN Hai-Bo; LI Dan; CAO Mao-Sheng; DOU Yan-Kun; CHEN Tao; WEN Bo; Simeon Agathopoulos

    2011-01-01

    Ni-doped SiC powder with improved dielectric and microwave absorption properties was prepared by selfpropagating high-temperature synthesis(SHS). The XRD analysis of the asynthesized powders suggests that Ni is accommodated in the sites of Si in the lattice of SiC, which shrinks in the presence of Ni. The experimental results show an improvement in the dielectric properties of the Ni-doped SiC powder in the frequency range of 2-18 GHz. The bandwidth of the reflection loss below-10 dB is broadened from 3.04(for pure SiC) to 4.56 GHz (for Ni-doped SiC), as well as the maximum reflection loss of produced powders from 13.34 to 22.57dB, indicating that Ni-doped SiC could be used as an effective microwave absorption material.

  7. Erratum; A Three-Position Spectral Line Survey of Sagittarius B2 between 218 and 263 GHz. II. Data Analysis

    Science.gov (United States)

    Nummelin, A.; Bergman, P.; Hjalmarson, Å.; Friberg, P.; Irvine, W. M.; Millar, T. J.; Ohishi, M.; Saito, S.

    2001-01-01

    In the paper ``A Three-Position Spectral Line Survey of Sagittarius B2 between 218 and 263 GHz. II. Data Analysis'' by A. Nummelin, P. Bergman, Å. Hjalmarson, P. Friberg, W. M. Irvine, T. J. Millar, M. Ohishi, and S. Saito (ApJS, 128, 213 [2000]), the affiliations for M. Ohishi and S. Saito were set incorrectly. The correct affiliation for M. Ohishi is National Astronomical Observatory of Japan, 2-21-1, Osawa, Mitaka, Tokyo 181-8588, Japan; ohishi@nao.ac.jp. The correct affiliation for S. Saito is Research Center for Development of Far-Infrared Region, Fukui University, 3-9-1 Bunkyo, Fukui 901-8507, Japan; saito@maxwell.apphy.fukui-u.ac.jp. The Press sincerely regrets this error.

  8. The stability and optical gap of zinc oxide clusters (ZnO)n (n = 2-18).

    Science.gov (United States)

    Zhao, Huxian; Chen, Xiaoshuang; Dong, Ruibin; Lu, Wei

    2012-01-01

    The stability and the optical band gap of the Zinc Oxide clusters (ZnO)n (n = 2-18) are investigated by using density functional theory (DFT) and the time-dependent density functional theory (TD-DFT), respectively. The differences between the HOMO-LUMO gap (delta(h-l)) and the optical gap (delta(opt)) are dramatic for small clusters (2 < or = n < or = 5). As the increasing of the cluster size, the differences become small. The results indicate that the stability and the optical gap are related to the sizes and symmetries of the clusters. Further, it is shown that the structures have much greater impact on the optical gap, there is the dipole-forbidden transition in the optical gap for high symmetric structures. PMID:22523957

  9. High frequency microphone measurements for transition detection on airfoils. Risø C2-18 appendix report

    DEFF Research Database (Denmark)

    Døssing, Mads

    Time series of pressure fluctuations has been obtained using high frequency microphones distributed over the surface of airfoils undergoing wind tunnel tests in the LM Windtunnel, owned by ’LM Glasfiber’, Denmark. The present report describes the dataanalysis, with special attention given...... to transition detection. It is argued that the transition point can be detected by observing the increase in the mean of the Fourier spectre and that thismethod is very stable froma numerical point of view. Other important issues are also discussed, e.g. the variation of pressure standard deviations (sound...... pressure) and Tollmien-Schlichting frequencies. The tests were made at Reynolds and Mach numbers corresponding to the operating conditions of a typical horizontal axis wind turbine (HAWT). The Risø B1-18, Risø C2-18 and NACA0015 profiles were tested and the measured transition points are reported....

  10. Dynamic 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography of liver tumours without blood sampling

    DEFF Research Database (Denmark)

    Keiding, S; Munk, O L; Schiøtt, K M;

    2000-01-01

    Positron emission tomography (PET) using 2-[18F]fluoro-2-deoxy-D-glucose (FDG) is a useful diagnostic tool for the detection of tumours. Using dynamic FDG PET, net metabolic clearance of FDG, K, can be calculated by Gjedde-Patlak analysis of the time course of the radioactivity concentrations in...

  11. 31 CFR 585.218 - Trade in United Nations Protected Areas of Croatia and those areas of the Republic of Bosnia and...

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Trade in United Nations Protected... HERZEGOVINA SANCTIONS REGULATIONS Prohibitions § 585.218 Trade in United Nations Protected Areas of Croatia... importation from, exportation to, or transshipment of goods through the United Nations Protected Areas in...

  12. CRYSTAL-STRUCTURE OF DEOXYGENATED LIMULUS-POLYPHEMUS SUBUNIT-II HEMOCYANIN AT 2.18-ANGSTROM RESOLUTION - CLUES FOR A MECHANISM FOR ALLOSTERIC REGULATION

    NARCIS (Netherlands)

    HAZES, B; MAGNUS, KA; BONAVENTURA, C; BONAVENTURA, J; DAUTER, Z; KALK, KH; HOL, WGJ

    1993-01-01

    The crystal structure of Limulus polyphemus subunit type II hemocyanin in the deoxygenated state has been determined to a resolution of 2.18 angstrom. Phase information for this first structure of a cheliceratan hemocyanin was obtained by molecular replacement using the crustacean hemocyanin structu

  13. Association between A218C polymorphism of the tryptophan-hydroxylase-1 gene, harm avoidance and binge eating behavior in bulimia nervosa.

    Science.gov (United States)

    Monteleone, Palmiero; Tortorella, Alfonso; Martiadis, Vassilis; Serino, Ismene; Di Filippo, Carmela; Maj, Mario

    2007-06-21

    Genes involved in serotonin transmission are likely involved in the biological predisposition to bulimia nervosa. We investigated whether the A218C polymorphism of the tryptophan-hydroxylase-1 gene was associated to bulimia nervosa and/or to some phenotypic aspects of the disorder. One hundred eighty Caucasian women (91 patients with bulimia nervosa and 89 healthy controls) were enrolled into the study. They underwent a blood sample collection for A218C polymorphism of the tryptophan-hydroxylase-1 genotyping and a clinical evaluation assessing comorbidity for Axis I and II psychiatric disorders, harm avoidance personality dimension and bulimic symptoms. The distribution of both tryptophan-hydroxylase-1 A218C genotypes and alleles did not significantly differ between patients and controls. Bulimic women with the AA genotype exhibited a more severe binge eating behavior and higher harm avoidance scores than those with CC genotype. These findings support the idea that tryptophan-hydroxylase-1 A218C polymorphism does not play a part in the genetic susceptibility to bulimia nervosa, but it seems to be involved in predisposing bulimic patients to a more disturbed eating behavior and higher harm avoidance.

  14. 75 FR 32773 - Auction of 218-219 MHz Service and Phase II 220 MHz Service Licenses Scheduled for December 7...

    Science.gov (United States)

    2010-06-09

    ... or fasteners. Any envelopes must be disposed of before entering the building. Commercial overnight.... Auction 89 will offer 1,420 licenses in the 218-219 MHz Service: 716 A Block licenses and 704 B Block... Bureau proposes to divide the auction into at least two stages, each characterized by a...

  15. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 218, Revision 1 (FGE.218Rev1): alpha,beta-Unsaturated aldehydes and precursors from subgroup 4.2 of FGE.19: Furfural derivatives

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister;

    .001], for which there was a request for genotoxicity data in FGE.218. Flavouring Group Evaluation 218 (FGE.218) consists of furfural [FL-no: 13.018] and seven substances structurally related to furfural, 5-methylfurfural [FL-no: 13.001], furfuryl alcohol [FL-no: 13.019] and five esters of furfuryl alcohol...... is expected to be oxidised to the alpha,beta-unsaturated aldehyde furfural. However, based on the data then available the Panel concluded that furfural is not of concern with respect to genotoxicity. Furthermore, the Panel concluded that not only furfural but also the structurally related furfuryl alcohol...... to 5-[(sulphoxy)methyl]furfural which shows genotoxic potential in vitro, 5-hydroxymethylfurfural could not be evaluated through the Procedure. Accordingly, the Panel concluded that 5-methylfurfural could not be evaluated through the Procedure either. Industry has submitted additional data on the 5...

  16. 2-deoxy-2-(18F)fluoro-D-glucose positron emission tomography/computed tomography imaging in paediatric oncology

    Institute of Scientific and Technical Information of China (English)

    John; Freebody; Eva; A; Wegner; Monica; A; Rossleigh

    2014-01-01

    Positron emission tomography(PET) is a minimally in-vasive technique which has been well validated for the diagnosis, staging, monitoring of response to therapy, and disease surveillance of adult oncology patients. Tra-ditionally the value of PET and PET/computed tomogra-phy(CT) hybrid imaging has been less clearly defined for paediatric oncology. However recent evidence has emerged regarding the diagnostic utility of these mo-dalities, and they are becoming increasingly important tools in the evaluation and monitoring of children with known or suspected malignant disease. Important indi-cations for 2-deoxy-2-(18F)fluoro-D-glucose(FDG) PET in paediatric oncology include lymphoma, brain tumours, sarcoma, neuroblastoma, Langerhans cell histiocytosis, urogenital tumours and neurofibromatosis type Ⅰ. This article aims to review current evidence for the use of FDG PET and PET/CT in these indications. Attention will also be given to technical and logistical issues, the description of common imaging pitfalls, and dosimetric concerns as they relate to paediatric oncology.

  17. Biodegradation and surfactant-mediated biodegradation of diesel fuel by 218 microbial consortia are not correlated to cell surface hydrophobicity

    Energy Technology Data Exchange (ETDEWEB)

    Owsianiak, Mikolaj; Szulc, Alicja; Chrzanowski, Lukasz; Bogacki, Mariusz [Poznan Univ. of Technology (Poland). Inst. of Chemical Technology and Engineering; Cyplik, Pawel; Olejnik-Schmidt, Agniezka K. [Poznan Univ. of Life Sciences (Poland). Dept. of Biotechnology and Food Microbiology; Heipieper, Hermann J. [Helmholtz Centre for Environmental Research - UFZ, Leipzig (Germany). Dept. of Environmental Biotechnology

    2009-09-15

    In this study, we elucidated the role of cell surface hydrophobicity (microbial adhesion to hydrocarbons method, MATH) and the effect of anionic rhamnolipids and nonionic Triton X-100 surfactants on biodegradation of diesel fuel employing 218 microbial consortia isolated from petroleum-contaminated soils. Applied enrichment procedure with floating diesel fuel as a sole carbon source in liquid cultures resulted in consortia of varying biodegradation potential and diametrically different cell surface properties, suggesting that cell surface hydrophobicity is a conserved parameter. Surprisingly, no correlations between cell surface hydrophobicity and biodegradation of diesel fuel were found. Nevertheless, both surfactants altered cell surface hydrophobicity of the consortia in similar manner: increased for the hydrophilic and decreased for the hydrophobic cultures. In addition to this, the surfactants exhibited similar influence on diesel fuel biodegradation: Increase was observed for initially slow-degrading cultures and the opposite for fast degraders. This indicates that in the surfactant-mediated biodegradation, effectiveness of surfactants depends on the specification of microorganisms and not on the type of surfactant. In contrary to what was previously reported for pure strains, cell surface hydrophobicity, as determined by MATH, is not a good descriptor of biodegrading potential for mixed cultures. (orig.)

  18. Elastic scattering for 16O + 12C at 140 MeV and 218 MeV

    International Nuclear Information System (INIS)

    In this work, angular distribution of cross sections have been measured for 12C(16O,16O)12C at two energies. The measurements were carried out in 0.50 intervals between 50-19.50C (lab.) at 140 MeV, 4.50-14.50 at 218 MeV. An optical model analysis of these strong structure angular distributions was done. Good fits of the data were obtained using the optical model search code GENOA with a full Woods-Saxon potential form. This yielded parameters subject to considerable ambiguities as it is known to occur for strongly absorbed particles. These ambiguities were explored in detail and it was found that both the real and the imaginary parts present some characteristics that have been found before for the real potential (as Igo relation for continous ambiguities and the fact that potentials with different diffusivities tend to have the same value at the strong absorption radii). It was found, among other results, that the real volume integral, the mean square radius, as well as the total reaction cross section (σsub(r)) cannot be determined unambiguously. A strong correlation was found between σsub(r) and the imaginary diffusivity. A systematic study of how the variation of the potential parameters affects the angular distribution is presented and some features of the diffraction structure of the angular distribution are discussed. (author)

  19. A Tape Method for Fast Characterization and Identification of Active Pharmaceutical Ingredients in the 2-18 THz Spectral Range

    Science.gov (United States)

    Kissi, Eric Ofosu; Bawuah, Prince; Silfsten, Pertti; Peiponen, Kai-Erik

    2015-03-01

    In order to find counterfeit drugs quickly and reliably, we have developed `tape method' a transmission spectroscopic terahertz (THz) measurement technique and compared it with a standard attenuated total reflection (ATR) THz spectroscopic measurement. We used well-known training samples, which include commercial paracetamol and aspirin tablets to check the validity of these two measurement techniques. In this study, the spectral features of some active pharmaceutical ingredients (APIs), such as aspirin and paracetamol are characterized for identification purpose. This work covers a wide THz spectral range namely, 2-18 THz. This proposed simple but novel technique, the tape method, was used for characterizing API and identifying their presence in their dosage forms. By comparing the spectra of the APIs to their dosage forms (powder samples), all distinct fingerprints present in the APIs are also present in their respective dosage forms. The positions of the spectral features obtained with the ATR techniques were akin to that obtained from the tape method. The ATR and the tape method therefore, complement each other. The presence of distinct fingerprints in this spectral range has highlighted the possibility of developing fast THz sensors for the screening of pharmaceuticals. It is worth noting that, the ATR method is applicable to flat faced tablets whereas the tape method is suitable for powders in general (e.g. curved surface tablets that require milling before measurement). Finally, we have demonstrated that ATR techniques can be used to screen counterfeit antimalarial tablets.

  20. Novel application of 2-[18F]fluoro-2-deoxy-D-glucose to study plant defenses

    International Nuclear Information System (INIS)

    Introduction: Since its first use in humans in 1976, 2-[18F]fluoro-2-deoxy-D-glucose (18FDG) continues to serve as a tracer to measure tissue glucose metabolism in medical imaging. Here we demonstrate a novel use for this tracer to study glycoside biosynthesis in plants as a measure of plant response to defense induction. Methods: Coupling autoradiography with radio high-performance liquid chromatography analysis of tissue extracts, we examined the combined effects of leaf wounding and treatment using the potent plant defense hormone, methyl jasmonate (MeJA), to measure tracer distribution and tracer use in secondary defense chemistry in Arabidopsis thaliana. We hypothesized that competing sinks like roots and reproductive tissues, as well as vascular architecture, would impact the induction of phenolic defenses of the plant that make use of glucose in glycoside formation by altering distribution and metabolic utilization of 18FDG. Results: Our studies showed that leaf orthostichy defined the major route of 18FDG transport in both vegetative and reproductive plants when a single petiole was cut as the entry point for tracer introduction. However, when nonorthostichous leaves were damaged and treated with MeJA, 18FDG was transported in its intact form to these leaves 3 h later, where it was incorporated into phenolic glycosides. Conclusions: Our work demonstrates a new use for 18FDG in plant science with insights into carbohydrate allocation that contradict conclusions of previous studies showing transport of resources away from damaged sites.

  1. Fiber Diffraction of the Prion-Forming Domain HET-s(218-289) Shows Dehydration-Induced Deformation of a Complex Amyloid Structure

    Energy Technology Data Exchange (ETDEWEB)

    Wan, William; Stubbs, Gerald [Vanderbilt

    2014-05-01

    Amyloids are filamentous protein aggregates that can be formed by many different proteins and are associated with both disease and biological functions. The pathogenicities or biological functions of amyloids are determined by their particular molecular structures, making accurate structural models a requirement for understanding their biological effects. One potential factor that can affect amyloid structures is hydration. Previous studies of simple stacked β-sheet amyloids have suggested that dehydration does not impact structure, but other studies indicated dehydration-related structural changes of a putative water-filled nanotube. Our results show that dehydration significantly affects the molecular structure of the fungal prion-forming domain HET-s(218–289), which forms a β-solenoid with no internal solvent-accessible regions. The dehydration-related structural deformation of HET-s(218–289) indicates that water can play a significant role in complex amyloid structures, even when no obvious water-accessible cavities are present.

  2. Diurnal variations of 218Po, 214Pb, and 214Po and their effect on atmospheric electrical conductivity in the lower atmosphere at Mysore

    International Nuclear Information System (INIS)

    The short-lived radon daughters (218Po, 214Pb, 214Bi and 214Po) are natural tracers in the troposphere in particular near the ground surface. They are electrically charged particles and are chemically reactive. As soon as they are formed they get attached to the aerosol particles of the atmosphere. Their behaviour is similar to that of aerosols with respect to their growth, transport, removal processes in the atmosphere. The electrical conductivity of the atmosphere is mainly due to the presence of highly mobile (small) ions. Hence the electrical conductivity of air at near the surface of the earth mainly due to 222Rn, 218Po, 214Pb, 214Bi and 214Po concentrations, and depends on aerosol concentrations and meteorological parameters. The individual radon progeny concentrations (218Po, 214Pb, and 214Po) are measured using Air Flow meter. The concentration of radon in the atmospheric air is measured using Low Level Radon Detection System. The total energy released due to both radon and its progeny is computed in energy units (eV cm-3s-1) and is converted into ion-pair production rate (No. cm-3 s-1), 32 eV being the energy producing one-ion pair. The atmospheric electrical conductivity (both positive and negative) is measured using a Gerdien's apparatus with two identical tubes. The average values of 218Po, 214Pb, and 214Po are respectively 13.70, 1.45 and 1.92 Bq m-3 respectively. The average value of positive and negative electrical conductivity are 5.08 x 10-14U-1 m-1 and 4.67 x 10-14 U-1 m-1. The concentrations of radon, its progeny, and positive and negative conductivity show a similar kind of diurnal variations with maximum in the early morning hours and a minimum during day time. The activity is higher in winter than in summer and rainy season. (author)

  3. Two-way shape memory effect and mechanical properties of Pulse Discharge Sintered Ni2.18Mn0.82Ga

    OpenAIRE

    Takagi, T; Khovailo, V.; Nagatomo, T.; Matsumoto, M.; Ohtsuka, M; T. Abe; Miki, H

    2003-01-01

    Mechanical and shape memory properties of a polycrystalline Ni2.18Mn0.82Ga alloy prepared by a PDS (Pulse Discharge Sintering) method were investigated. It was found that the material demonstrates the two-way shape memory effect after a loading - unloading cycle performed in the martensitic state, i. e. essentially without special training. The samples exhibiting the two-way shape memory effect show a significant enhancement in the magnitude of magnetic-field-induced strain.

  4. Schwangerschaftsabbruch als sprachliches Problem : eine linguistische Textanalyse ausgewählter Gesetzentwürfe zur Reform des § 218 StGB

    OpenAIRE

    Beckmann, Pia

    2004-01-01

    Die Arbeit stellt eine linguistische Textanalyse von Gesetzentwürfen zur Reform des § 218 StGB aus dem Jahr 1991 dar. Mitspieler (Aktanten) in den jeweiligen Handlungsframes der Gesetzentwürfe sind die Frau als Entscheidungsträgerin für die Handlung "Schwangerschaftsabbruch", der Arzt, der den Schwangerschaftsabbruch vornimmt, und der Embryo, der abgetrieben wird. Unter Rückgriff auf die Prototypensemantik werden die Handlung und die Aktanten in dem jeweiligen Textzusammenhang der einzelnen G...

  5. Heterogeneous Seeding of a Prion Structure by a Generic Amyloid Form of the Fungal Prion-forming Domain HET-s(218-289)

    Energy Technology Data Exchange (ETDEWEB)

    Wan, William; Bian, Wen; McDonald, Michele; Kijac, Aleksandra; Wemmer, David E.; Stubbs, Gerald [UCB; (Vanderbilt); (LBNL)

    2013-11-13

    The fungal prion-forming domain HET-s(218–289) forms infectious amyloid fibrils at physiological pH that were shown by solid-state NMR to be assemblies of a two-rung β-solenoid structure. Under acidic conditions, HET-s(218–289) has been shown to form amyloid fibrils that have very low infectivity in vivo, but structural information about these fibrils has been very limited. We show by x-ray fiber diffraction that the HET-s(218–289) fibrils formed under acidic conditions have a stacked β-sheet architecture commonly found in short amyloidogenic peptides and denatured protein aggregates. At physiological pH, stacked β-sheet fibrils nucleate the formation of the infectious β-solenoid prions in a process of heterogeneous seeding, but do so with kinetic profiles distinct from those of spontaneous or homogeneous (seeded with infectious β-solenoid fibrils) fibrillization. Several serial passages of stacked β-sheet-seeded solutions lead to fibrillization kinetics similar to homogeneously seeded solutions. Our results directly show that structural mutation can occur between substantially different amyloid architectures, lending credence to the suggestion that the processes of strain adaptation and crossing species barriers are facilitated by structural mutation.

  6. Contribution of plated-out 218Po and 214Po to measurements of airborne 222Rn and daughters with plastic (CR-39) nuclear track detectors

    Science.gov (United States)

    Kahn, Bernd; Wang, Zuoyuan; Sensistaffar, Edwin

    1984-01-01

    The fraction of alpha-particle tracks due to radioactivity plated out on its surface was measured for CR-39 nuclear track detector foils used to determine working level values in air. Bare foils were exposed to known concentrations of airborne 222Rn and its short-lived daughters in a calibration chamber. The amounts of 218Po and 214Po on the foil surface were measured with a calibrated diffused junction detector-spectrometer system immediately after the foils were removed from the chamber. Deposition was mostly by 218Po, with some 214Pb but essentially no 214Bi. The track density due to the plated-out radionuclides and the 222Rn, 218Po, and 214Po in chamber air was calculated and compared to the value measured by electrochemical etching. The calculated values generally were slightly above the measured values. On the basis of these calculations, the deposited radioactivity contributed slightly less than one-half of the total tracks in one test and slightly more than two-thirds in another. This effect complicates calibration of the detector relative to airborne radon daughters.

  7. Bacillus velezensis RC 218 as a biocontrol agent to reduce Fusarium head blight and deoxynivalenol accumulation: Genome sequencing and secondary metabolite cluster profiles.

    Science.gov (United States)

    Palazzini, Juan M; Dunlap, Christopher A; Bowman, Michael J; Chulze, Sofía N

    2016-11-01

    Bacillus subtilis RC 218 was originally isolated from wheat anthers as a potential antagonist of Fusarium graminearum, the causal agent of Fusarium head blight (FHB). It was demonstrated to have antagonist activity against the plant pathogen under in vitro and greenhouse assays. The current study extends characterizing B. subtilis RC 218 with a field study and genome sequencing. The field study demonstrated that B. subtilis RC 218 could reduce disease severity and the associated mycotoxin (deoxynivalenol) accumulation, under field conditions. The genome sequencing allowed us to accurately determine the taxonomy of the strain using a phylogenomic approach, which places it in the Bacillus velezensis clade. In addition, the draft genome allowed us to use bioinformatics to mine the genome for potential metabolites. The genome mining allowed us to identify 9 active secondary metabolites conserved by all B. velezensis strains and one additional secondary metabolite, the lantibiotic ericin, which is unique to this strain. This study represents the first confirmed production of ericin by a B. velezensis strain. The genome also allowed us to do a comparative genomics with its closest relatives and compare the secondary metabolite production of the publically available B. velezensis genomes. The results showed that the diversity in secondary metabolites of strains in the B. velezensis clade is driven by strains making different antibacterials. PMID:27664721

  8. 2'[(18)F]-fluoroethylrhodamine B is a promising radiotracer to measure P-glycoprotein function.

    Science.gov (United States)

    Trencsényi, György; Kertész, István; Krasznai, Zoárd T; Máté, Gábor; Szalóki, Gábor; Szabó Judit, P; Kárpáti, Levente; Krasznai, Zoltán; Márián, Teréz; Goda, Katalin

    2015-07-10

    In vivo detection of the emergence of P-glycoprotein (Pgp) mediated multidrug resistance in tumors could be beneficial for patients treated with anticancer drugs. PET technique in combination with appropriate radiotracers could be the most convenient method for detection of Pgp function. Rhodamine derivatives are validated fluorescent probes for measurement of mitochondrial membrane potential and also Pgp function. The aim of this study was to investigate whether 2'[(18)F]-fluoroethylrhodamine B ((18)FRB) a halogenated rhodamine derivative previously synthesized for PET assessment of myocardial perfusion preserved its Pgp substrate character. ATPase assay as well as accumulation experiments carried out using Pgp(+) and Pgp(-) human gynecologic (A2780/A2780(AD) and KB-3-1/KB-V1) and a mouse fibroblast cell pairs (NIH 3T3 and NIH 3T3 MDR1) were applied to study the interaction of (18)FRB with Pgp. ATPase assay proved that (18)FRB is a high affinity substrate of Pgp. Pgp(-) cells accumulated the (18)FRB rapidly in accordance with its lipophilic character. Dissipation of the mitochondrial proton gradient by a proton ionophore CCCP decreased the accumulation of rhodamine 123 (R123) and (18)FRB into Pgp(-) cells. Pgp(+) cells exhibited very low R123 and (18)FRB accumulation (around 1-8% of the Pgp(-) cell lines) which was not sensitive to the mitochondrial proton gradient; rather it was increased by the Pgp inhibitor cyclosporine A (CsA). Based on the above data we conclude that (18)FRB is a high affinity Pgp substrate and consequently a potential PET tracer to detect multidrug resistant tumors as well as the function of physiological barriers expressing Pgp.

  9. Radiation dosimetry estimation of N-(2-[18F]fluoropropionyl)- L-glutamate based on the mice distribution data

    International Nuclear Information System (INIS)

    N-(2-[18F]fluoropropionyl)-L-glutamate([18F]FPGLU) was a recently developed potential amino acid tracer for tumor imaging with positron emission tomography–computer tomography (PET–CT). The absorbed and effective radiation doses resulting from the intravenous administration of [18F]FPGLU were estimated using biodistribution data from normal mice. The methodology recommended by Medical Internal Radiation Dose Committee (MIRD) was used to estimate the doses. The highest uptake of [18F]FPGLU was found in the kidneys, followed by the liver and lung. The kidneys were the organ received the highest absorbed dose, 58.4 μGy/MBq, the brain received the lowest dose, 5.5 μGy/MBq, and other organs received doses in the range of 8.3–11.9 μGy/MBq. The effective dose was 17.0 μSv/MBq. The data show that a 370 MBq (10 mCi) injection of [18F]FPGLU would lead to an estimated effective dose of 6.3 mSv, which is within the accepted range of routine nuclear medicine investigations. - Highlights: • The absorbed and effective radiation dosimetry of [18F]FPGLU was estimated using the biodistribution data from normal mice. • A 370 MBq (10 mCi) injection of [18F] FPGLU would lead to an estimated effective dose of 6.3 mSv, which is within the accepted range of routine nuclear medicine investigations. • [18F]FPGLU is a safe amino acid PET tracer for imaging and can be used in further clinical study

  10. Response of the unattached 218Po activity size distribution in H2O-SO2-N2 atmospheres

    International Nuclear Information System (INIS)

    The response of the unattached 218Po activity size distribution to variations in H2O and SO2 concentration was investigated in a high-purity N2 atmosphere. Lognormal size distributions were reconstructed from screen diffusion battery data using a random search and optimization procedure. For relative humidities of 1% to 90%, SO2 concentrations of 0-6 ppm, and residence times of 38 s, median diameters of the unattached mode ranged from 0.50 (± 0.04) to 0.80 (± 0.06) nm, corresponding to diffusion coefficients of 0.1-0.05 cm2 s-1. Increases in water vapor concentration resulted in an enhanced rate of ion neutralization and suppression of ion cluster formation. Decreases in cluster diameter with increasing humidity were therefore observed. Addition of SO2 at constant relative humidity resulted in an initial increase in diameter, with a subsequent decrease. Geometric standard deviations averaged 1.05 (± 0.01) to 1.06 (± 0.01) in all cases, with the unattached fraction comprising 83% to 88% of the total distribution. Results suggest that increases in water vapor concentration enhance neutralization in the immediate vicinity of the recoil path through water radiolysis. Conversion of OH to H2OSO4 on addition of SO2 provides a binary condensable phase capable of clustering around the ion at low relative humidities, increasing particle size. High H2O and SO2 concentrations enhance neutralization through electron scavenging and subsequent ion collision near the end of the recoil path, decreasing the number of available cluster sites and suppressing cluster formation. This reduction is more significant than the increasing size of the stable ion cluster, with increasing H2O and H2SO4 concentrations as predicted by Raes, resulting in decreases in both median diameter and distribution spread

  11. 非小细胞肺癌血浆miR-223、miR-93和miR-218的表达及其临床意义%Expression and clinical value analysis of plasma miR-223, miR-93 and miR-218 in non-small lung cancer

    Institute of Scientific and Technical Information of China (English)

    蔡静清; 王宁; 张敏

    2014-01-01

    Objective To explore the levels of plasma miR⁃223, miR⁃93 and miR⁃218 in non⁃small lung cancer( NSCLC) and analysis the relationship between the 3 indicators and clinicopathological parameters of NSCLC. Methods Plasma samples from 85 NSCLC patients before treatment were collected as NSCLC group. The real⁃time quantitative RT⁃PCR( qRT⁃PCR) was used to detect the levels of miR⁃223, miR⁃93 and miR⁃218 and the clinicopathological parameters of NSCLC patients were collected. The clinicopatho⁃logical parameters of patients with different levels of miR⁃223, miR⁃93 and miR⁃218 were compared. The receiver operating characteris⁃tic curve( ROC) was employed to analysis the clinical value of plasma miR⁃223, miR⁃93 and miR⁃218 in the diagnosis of NSCLC. Meanwhile, the plasma samples from 90 healthy volunteers at the same time were selected as control( control group) . Results There were higher levels of miR⁃223 and miR⁃93 but lower miR⁃218 in NSCLC group compaired with control group with significant difference ( P<0�05) . The level of miR⁃223 was related with TNM stage and tumor size, and miR⁃93 was related with histological type and lymph node metastasis, and miR⁃218 was related with tumor size and degree of differentiation, showing with significant difference ( P all<0�05) . The plasma level of miR⁃223 was positively correlated with miR⁃93( r=0�411) , but miR⁃223 and miR⁃93 were negatively cor⁃related with miR⁃218(r=-0�361 and r=-0�451)with statistically significance(P<0�05). The AUC, sensitivity and specificity of plasma miR⁃223, miR⁃93 and miR⁃218 in the diagnosis of NSCLC were 0�926, 95�2% and 87�1%, 0�912, 88�4% and 92�5%, and 0�941, 92�7% and 84�4%, higher than 0�774, 75�1% and 66�2% of carcinoembryonic antigen( CEA) . The combined efficiency of miR⁃223, miR⁃93 and miR⁃218 in NSCLC was superior to that alone. Conclusion There are higher expression of miR⁃223 and

  12. Evaluation of lymphocyte levels in a random sample of 218 elderly individuals from São Paulo city

    Directory of Open Access Journals (Sweden)

    Daniela Teixeira

    2011-10-01

    Full Text Available BACKGROUND: Age-associated changes in the immune system cause decreased protection after vaccination and increased rates of infections and tumor development. METHODS: Lymphocyte percentages were compared by gender and age to establish differences between subtypes. Three mL blood samples were obtained from 218 randomly selected individuals (60-101 years old who live in São Paulo city. Blood was lysed with Tris phosphate buffer and stained for 30 minutes with monoclonal antibodies (CD3PerCP, CD4FITC, CD8Pe, CD19Pe for analysis by flow cytometry. Statistical analysis was by ANOVA. RESULTS: The percentage of CD4+ T cells (p-value = 0.005 and the CD4/CD8 ratio (p-value = 0.010 were lower in men, whereas the percentage of CD8+ T cells was lower (p-value = 0.002 in women; the percentage of B cells (CD19+ was similar between groups. Individuals grouped by gender and age range and compared showed a drop in CD4+ cells in 75 to 79-year-old men (female: 46.1% ± 8.1% and male: 38.8% ± 10.5%; p-value = 0.023. Also, the 80 to 84-year-old group of men had a higher percentage of CD8+ (female: 20.8% ± 8.2%, and male: 27.2% ± 8.2%; p-value = 0.032. Low percentages of B cells were detected in men in the 75 to 79-year-old (p-value = 0.003, 85 to 89-year-old (p-value = 0.020 and older than 90 year old (p-value = 0.002 age ranges. CONCLUSION: Elderly men present with more changes in lymphocyte subsets compared to elderly women. These findings could demonstrate impairment in the immune response since the lower CD4+ in men would provide less help to B cells (also lower in men in terms of antibody production. In addition, the increase in CD8+ cells in this group could represent chronic inflammation observed during the aging process.

  13. Diagnosis of pseudoprogression in patients with glioblastoma using O-(2-[18F]fluoroethyl)-l-tyrosine PET

    International Nuclear Information System (INIS)

    The follow-up of glioblastoma patients after radiochemotherapy with conventional MRI can be difficult since reactive alterations to the blood-brain barrier with contrast enhancement may mimic tumour progression (i.e. pseudoprogression, PsP). The aim of this study was to assess the clinical value of O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) PET in the differentiation of PsP and early tumour progression (EP) after radiochemotherapy of glioblastoma. A group of 22 glioblastoma patients with new contrast-enhancing lesions or lesions showing increased enhancement (>25 %) on standard MRI within the first 12 weeks after completion of radiochemotherapy with concomitant temozolomide (median 7 weeks) were additionally examined using amino acid PET with 18F-FET. Maximum and mean tumour-to-brain ratios (TBRmax, TBRmean) were determined. 18F-FET uptake kinetic parameters (i.e. patterns of time-activity curves, TAC) were also evaluated. Classification as PsP or EP was based on the clinical course (no treatment change at least for 6 months), follow-up MR imaging and/or histopathological findings. Imaging results were also related to overall survival (OS). PsP was confirmed in 11 of the 22 patients. In patients with PsP, 18F-FET uptake was significantly lower than in patients with EP (TBRmax 1.9 ± 0.4 vs. 2.8 ± 0.5, TBRmean 1.8 ± 0.2 vs. 2.3 ± 0.3; both P < 0.001) and presence of MGMT promoter methylation was significantly more frequent (P = 0.05). Furthermore, a TAC type II or III was more frequently present in patients with EP (P = 0.04). Receiver operating characteristic analysis showed that the optimal 18F-FET TBRmax cut-off value for identifying PsP was 2.3 (sensitivity 100 %, specificity 91 %, accuracy 96 %, AUC 0.94 ± 0.06; P < 0.001). Univariate survival analysis showed that a TBRmax <2.3 predicted a significantly longer OS (median OS 23 vs. 12 months; P = 0.046). 18F-FET PET may facilitate the diagnosis of PsP following radiochemotherapy of glioblastoma. (orig.)

  14. Continuous monitoring α-activity on aerosol filters by the pseudo-coincidence-technique. Explicitly taking into account the short lived Po-218 activity

    International Nuclear Information System (INIS)

    Pseudo-coincidence-technique is applied to continuous monitoring of α-activity on aerosolfilters by proportional counters. Filter activity can markedly increase or decrease by changing air conditions especially by the amount of short lived Po-218 activity. Conditions of constant proportions of activity concentrations for the short lived species for operating this technique are seldom fulfilled. The dynamic behavior of artificial (long lived) and natural (short lived) activity is mathematically modelled and the measured moving count rates are analyzed under this model by a multivariate regression analysis for activity concentrations of artificial resp. short lived activity. Results are compared to standard recommendations of DIN ISO 11929.

  15. A program for calculating load coefficient matrices utilizing the force summation method, L218 (LOADS). Volume 2: Supplemental system design and maintenance document

    Science.gov (United States)

    Anderson, L. R.; Miller, R. D.

    1979-01-01

    The LOADS computer program L218 which calculates dynamic load coefficient matrices utilizing the force summation method is described. The load equations are derived for a flight vehicle in straight and level flight and excited by gusts and/or control motions. In addition, sensor equations are calculated for use with an active control system. The load coefficient matrices are calculated for the following types of loads: (1) translational and rotational accelerations, velocities, and displacements; (2) panel aerodynamic forces; (3) net panel forces; and (4) shears, bending moments, and torsions.

  16. Interactions of Neuropathogenic Escherichia coli K1 (RS218) and Its Derivatives Lacking Genomic Islands with Phagocytic Acanthamoeba castellanii and Nonphagocytic Brain Endothelial Cells

    Science.gov (United States)

    Yousuf, Farzana Abubakar; Yousuf, Zuhair; Iqbal, Junaid; Siddiqui, Ruqaiyyah; Khan, Hafsa; Khan, Naveed Ahmed

    2014-01-01

    Here we determined the role of various genomic islands in E. coli K1 interactions with phagocytic A. castellanii and nonphagocytic brain microvascular endothelial cells. The findings revealed that the genomic islands deletion mutants of RS218 related to toxins (peptide toxin, α-hemolysin), adhesins (P fimbriae, F17-like fimbriae, nonfimbrial adhesins, Hek, and hemagglutinin), protein secretion system (T1SS for hemolysin), invasins (IbeA, CNF1), metabolism (D-serine catabolism, dihydroxyacetone, glycerol, and glyoxylate metabolism) showed reduced interactions with both A. castellanii and brain microvascular endothelial cells. Interestingly, the deletion of RS218-derived genomic island 21 containing adhesins (P fimbriae, F17-like fimbriae, nonfimbrial adhesins, Hek, and hemagglutinin), protein secretion system (T1SS for hemolysin), invasins (CNF1), metabolism (D-serine catabolism) abolished E. coli K1-mediated HBMEC cytotoxicity in a CNF1-independent manner. Therefore, the characterization of these genomic islands should reveal mechanisms of evolutionary gain for E. coli K1 pathogenicity. PMID:24818136

  17. Interactions of Neuropathogenic Escherichia coli K1 (RS218 and Its Derivatives Lacking Genomic Islands with Phagocytic Acanthamoeba castellanii and Nonphagocytic Brain Endothelial Cells

    Directory of Open Access Journals (Sweden)

    Farzana Abubakar Yousuf

    2014-01-01

    Full Text Available Here we determined the role of various genomic islands in E. coli K1 interactions with phagocytic A. castellanii and nonphagocytic brain microvascular endothelial cells. The findings revealed that the genomic islands deletion mutants of RS218 related to toxins (peptide toxin, α-hemolysin, adhesins (P fimbriae, F17-like fimbriae, nonfimbrial adhesins, Hek, and hemagglutinin, protein secretion system (T1SS for hemolysin, invasins (IbeA, CNF1, metabolism (D-serine catabolism, dihydroxyacetone, glycerol, and glyoxylate metabolism showed reduced interactions with both A. castellanii and brain microvascular endothelial cells. Interestingly, the deletion of RS218-derived genomic island 21 containing adhesins (P fimbriae, F17-like fimbriae, nonfimbrial adhesins, Hek, and hemagglutinin, protein secretion system (T1SS for hemolysin, invasins (CNF1, metabolism (D-serine catabolism abolished E. coli K1-mediated HBMEC cytotoxicity in a CNF1-independent manner. Therefore, the characterization of these genomic islands should reveal mechanisms of evolutionary gain for E. coli K1 pathogenicity.

  18. An Ammonia Spectral Map of the L1495-B218 Filaments in the Taurus Molecular Cloud : I. Physical Properties of Filaments and Dense cores

    CERN Document Server

    Seo, Young Min; Goldsmith, Paul; Ward-Thompson, Derek; Kirk, Jason M; Schmalzl, Markus; Lee, Jeong-Eun; Friesen, Rachel; Langston, Glen; Masters, Joe; Garwood, Robert W

    2015-01-01

    We present deep NH$_3$ observations of the L1495-B218 filaments in the Taurus molecular cloud covering over a 3 degree angular range using the K-band focal plane array on the 100m Green Bank Telescope. The L1495-B218 filaments form an interconnected, nearby, large complex extending over 8 pc. We observed NH$_3$ (1,1) and (2,2) with a spectral resolution of 0.038 km/s and a spatial resolution of 31$"$. Most of the ammonia peaks coincide with intensity peaks in dust continuum maps at 350 $\\mu$m and 500 $\\mu$m. We deduced physical properties by fitting a model to the observed spectra. We find gas kinetic temperatures of 8 $-$ 15 K, velocity dispersions of 0.05 $-$ 0.25 km/s, and NH$_3$ column densities of 5$\\times$10$^{12}$ $-$ 1$\\times$10$^{14}$ cm$^{-2}$. The CSAR algorithm, which is a hybrid of seeded-watershed and binary dendrogram algorithms, identifies a total of 55 NH$_3$ structures including 39 leaves and 16 branches. The masses of the NH$_3$ sources range from 0.05 M$_\\odot$ to 9.5 M$_\\odot$. The masses...

  19. THE FIRST CIRCUMSTELLAR DISK IMAGED IN SILHOUETTE AT VISIBLE WAVELENGTHS WITH ADAPTIVE OPTICS: MagAO IMAGING OF ORION 218-354

    Energy Technology Data Exchange (ETDEWEB)

    Follette, Katherine B.; Close, Laird M.; Males, Jared R.; Wu, Ya-Lin; Morzinski, Katie M.; Hinz, Philip; Rodigas, Timothy J. [Steward Observatory, The University of Arizona, 933 N Cherry Avenue, Tucson, AZ 85721 (United States); Kopon, Derek [Max Planck Institute for Astronomy, Königstuhl 17, D-69117 Heidelberg (Germany); Puglisi, Alfio; Esposito, Simone; Riccardi, Armando; Pinna, Enrico; Xompero, Marco; Briguglio, Runa [INAF - Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy)

    2013-09-20

    We present high-resolution adaptive optics (AO) corrected images of the silhouette disk Orion 218-354 taken with Magellan AO (MagAO) and its visible light camera, VisAO, in simultaneous differential imaging mode at Hα. This is the first image of a circumstellar disk seen in silhouette with AO and is among the first visible light AO results in the literature. We derive the disk extent, geometry, intensity, and extinction profiles and find, in contrast with previous work, that the disk is likely optically thin at Hα. Our data provide an estimate of the column density in primitive, ISM-like grains as a function of radius in the disk. We estimate that only ∼10% of the total submillimeter derived disk mass lies in primitive, unprocessed grains. We use our data, Monte Carlo radiative transfer modeling, and previous results from the literature to make the first self-consistent multiwavelength model of Orion 218-354. We find that we are able to reproduce the 1-1000 μm spectral energy distribution with a ∼2-540 AU disk of the size, geometry, small versus large grain proportion, and radial mass profile indicated by our data. This inner radius is a factor of ∼15 larger than the sublimation radius of the disk, suggesting that it is likely cleared in the very interior.

  20. MicroRNAs MiR-218, MiR-125b, and Let-7g predict prognosis in patients with oral cavity squamous cell carcinoma.

    Directory of Open Access Journals (Sweden)

    Shih-Chi Peng

    Full Text Available MicroRNAs (miRNAs have a major impact on regulatory networks in human carcinogenesis. In this study, we sought to investigate the prognostic significance of miRNAs in patients with oral cavity squamous cell carcinoma (OSCC. In a discovery phase, RNA was extracted from 58 OSCC tumor samples and paired normal tissues. MiRNAs expression was evaluated with TaqMan Array Card and TaqMan MicroRNA assays. The prognostic significance of the miRNA signature identified in the discovery phase was validated by qRT-PCR in a replication set consisting of 141 formalin-fixed, paraffin-embedded (FFPE samples. We identified a miRNA regulatory network centered on the three hub genes (SP1, MYC, and TP53 that predicted distinct clinical endpoints. Three miRNAs (miR-218, miR-125b, and let-7g and their downstream response genes had a concordant prognostic significance on disease-free survival and disease-specific survival rates. In addition, patients with a reduced expression of miR-218, miR-125b, and let-7g have a higher risk of poor outcomes in presence of specific risk factors (p-stage III-IV, pT3-4, or pN+. Our findings indicate that specific miRNAs have prognostic significance in OSCC patients and may improve prognostic stratification over traditional risk factors.

  1. MicroRNA-218通过靶向多梳家族 Bmi1基因抑制胶质瘤的侵袭、迁移、增殖和肿瘤干细胞样细胞的自我更新%MicroRNA-218 inhibits glioma invasion,mi-gration,proliferation,and cancer stem-like cell self-renewal by targeting the polycomb group gene Bmi1

    Institute of Scientific and Technical Information of China (English)

    涂艳阳; 高兴春; 李刚; 付华林; 崔大祥; 刘辉; 金卫林; 张永生

    2014-01-01

    AIM:To study the molecular mechanism of microR-NA-218 inhibiting glioma invasion,migration,proliferation,and cancer stem-like cell self-renewal.METHODS:miR-218 was overexpressed in glioma cells.Then quantitative reverse transcrip-tion PCR (qRT-PCR)and western blotting analysis were used to detect the expression level of Bmi1.Wound healing and in vitro migration assays were employed to study the glioma migration and proliferation.The effect of miR-218 on cancer growth was deter-mined via animal studies.Bioinformatics anlysis was performed to predict the direct targets of miR-218.Predicted target genes were verified using qRT-PCR,western bloting,luciferase reporter and immunofluorescence.The effect of miR-218 on self-renewal ca-pacity of glioma stem-like cells was examed using tumor sphere formation and limiting dilution assay.To determin the function of Bmi1 in glioma migration and proliferation,a RNAi vector of Bmi1 was constructed and introduced into glioma cells.Further-more,effect of miR-218 on genes involved in glioma development were determined using microarray-based gene expression analysis. RESULTS:Bmi1 is a direct target of miR-218.miR-218 inhibit glioma migration,proliferation,and cancer stem-like cell self-re-newal by targeting Bmi1.Moreover,miR-218 also regulates a se-ries of genes involved in glioma development.CONCLUSION:As a tumor suppressor,miR-218 prevents migration,invasion, proliferation,and stemlike qualities in glioma cells.%目的:探讨microRNA-218抑制胶质瘤侵袭、迁移、增殖和抑制肿瘤干细胞样细胞自我更新的分子机制。方法:在胶质瘤细胞中过表达miR-218,利用定量逆转录PCR(qRT-PCR)和免疫印迹法(Western blotting)检测Bmi1的表达水平,并利用创伤修复和体外迁移实验检测胶质瘤细胞的迁移和增殖能力;通过裸鼠移植瘤实验,检测体内过表达miR-218对胶质瘤生长的影响;利用生物信息学手段预测miR-218的直接靶标,并通过q

  2. Diurnal variations of 218Po, 214Pb, and 214Po and their effect on atmospheric electrical conductivity in the lower atmosphere at Mysore city, Karnataka State, India

    International Nuclear Information System (INIS)

    The short-lived radon daughters (218Po, 214Pb, 214Bi and 214Po) are natural tracers in the troposphere, in particular near the ground surface. They are electrically charged particles and are chemically reactive. As soon as they are formed they get attached to the aerosol particles of the atmosphere. The behavior of radon daughters is similar to that of aerosols with respect to their growth, transport and removal processes in the atmosphere. The electrical conductivity of the atmosphere is mainly due to the presence of highly mobile ions. Galactic cosmic rays are the main source of ionization in the planetary boundary layer; however, near the surface of the earth, ions are produced mainly by decays of natural radioactive gases emanating from the soil surface and by radiations emitted directly from the surface. Hence the electrical conductivity of air near the surface of the earth is mainly due to radiations emitted by 222Rn, 218Po, 214Pb, 214Bi and 214Po, and depends on aerosol concentrations and meteorological parameters. In the present work the diurnal and seasonal variations of radon and its progeny concentrations are studied using Low Level Radon Detection System and Airflow Meter respectively. Atmospheric electrical conductivity of both positive and negative polarities is measured using a Gerdien Condenser. All the measurements were carried out simultaneously at one location in Mysore city (12°N, 76°E), India. The diurnal variation of atmospheric electrical conductivity was found to be similar to that of ion pair production rate estimated from radon and its progeny concentrations with a maximum in the early morning hours and minimum during day time. The annual average concentrations of 222Rn, 218Po, 214Pb, and 214Po at the study location were found to be 21.46, 10.88, 1.78 and 1.80 Bq m−3 respectively. The annual average values of positive and negative atmospheric electrical conductivity were found to be 18.1 and 16.6 f S m−1 respectively. The radon and

  3. Diurnal variations of (218)Po, (214)Pb, and (214)Po and their effect on atmospheric electrical conductivity in the lower atmosphere at Mysore city, Karnataka State, India.

    Science.gov (United States)

    Pruthvi Rani, K S; Paramesh, L; Chandrashekara, M S

    2014-12-01

    The short-lived radon daughters ((218)Po, (214)Pb, (214)Bi and (214)Po) are natural tracers in the troposphere, in particular near the ground surface. They are electrically charged particles and are chemically reactive. As soon as they are formed they get attached to the aerosol particles of the atmosphere. The behavior of radon daughters is similar to that of aerosols with respect to their growth, transport and removal processes in the atmosphere. The electrical conductivity of the atmosphere is mainly due to the presence of highly mobile ions. Galactic cosmic rays are the main source of ionization in the planetary boundary layer; however, near the surface of the earth, ions are produced mainly by decays of natural radioactive gases emanating from the soil surface and by radiations emitted directly from the surface. Hence the electrical conductivity of air near the surface of the earth is mainly due to radiations emitted by (222)Rn, (218)Po, (214)Pb, (214)Bi and (214)Po, and depends on aerosol concentrations and meteorological parameters. In the present work the diurnal and seasonal variations of radon and its progeny concentrations are studied using Low Level Radon Detection System and Airflow Meter respectively. Atmospheric electrical conductivity of both positive and negative polarities is measured using a Gerdien Condenser. All the measurements were carried out simultaneously at one location in Mysore city (12°N, 76°E), India. The diurnal variation of atmospheric electrical conductivity was found to be similar to that of ion pair production rate estimated from radon and its progeny concentrations with a maximum in the early morning hours and minimum during day time. The annual average concentrations of (222)Rn, (218)Po, (214)Pb, and (214)Po at the study location were found to be 21.46, 10.88, 1.78 and 1.80 Bq m(-3) respectively. The annual average values of positive and negative atmospheric electrical conductivity were found to be 18.1 and 16.6 f S m(-1

  4. The Atacama Cosmology Telescope: A Measurement of the Cosmic Microwave Background Power Spectrum at 148 and 218 GHz from the 2008 Southern Survey

    CERN Document Server

    Das, Sudeep; Ade, Peter A R; Aguirre, Paula; Amir, Mandana; Appel, John W; Barrientos, L Felipe; Battistelli, Elia S; Bond, J Richard; Brown, Ben; Burger, Bryce; Chervenak, Jay; Devlin, Mark J; Dicker, Simon R; Doriese, W Bertrand; Dunkley, Joanna; Dünner, Rolando; Essinger-Hileman, Thomas; Fisher, Ryan P; Fowler, Joseph W; Hajian, Amir; Halpern, Mark; Hasselfield, Matthew; Hernández-Monteagudo, Carlos; Hilton, Gene C; Hilton, Matt; Hincks, Adam D; Hlozek, Renée; Huffenberger, Kevin M; Hughes, David H; Hughes, John P; Infante, Leopoldo; Irwin, Kent D; Juin, Jean Baptiste; Kaul, Madhuri; Klein, Jeff; Kosowsky, Arthur; Lau, Judy M; Limon, Michele; Lin, Yen-Ting; Lupton, Robert H; Marsden, Danica; Martocci, Krista; Mauskopf, Phil; Menanteau, Felipe; Moodley, Kavilan; Moseley, Harvey; Netterfield, Calvin B; Niemack, Michael D; Nolta, Michael R; Page, Lyman A; Parker, Lucas; Partridge, Bruce; Reid, Beth; Sehgal, Neelima; Sherwin, Blake D; Sievers, Jon; Spergel, David N; Staggs, Suzanne T; Swetz, Daniel S; Switzer, Eric R; Thornton, Robert; Trac, Hy; Tucker, Carole; Warne, Ryan; Wollack, Ed; Zhao, Yue

    2010-01-01

    We present measurements of the cosmic microwave background (CMB) power spectrum made by the Atacama Cosmology Telescope at 148 GHz and 218 GHz, as well as the cross-frequency spectrum between the two channels. Our results clearly show the second through the seventh acoustic peaks in the CMB power spectrum. The measurements of these higher-order peaks provide an additional test of the {\\Lambda}CDM cosmological model. At l > 3000, we detect power in excess of the primary anisotropy spectrum of the CMB. At lower multipoles 500 < l < 3000, we find evidence for gravitational lensing of the CMB in the power spectrum at the 2.8{\\sigma} level. We also detect a low level of Galactic dust in our maps, which demonstrates that we can recover known faint, diffuse signals.

  5. THE ATACAMA COSMOLOGY TELESCOPE: A MEASUREMENT OF THE COSMIC MICROWAVE BACKGROUND POWER SPECTRUM AT 148 AND 218 GHz FROM THE 2008 SOUTHERN SURVEY

    International Nuclear Information System (INIS)

    We present measurements of the cosmic microwave background (CMB) power spectrum made by the Atacama Cosmology Telescope at 148 GHz and 218 GHz, as well as the cross-frequency spectrum between the two channels. Our results clearly show the second through the seventh acoustic peaks in the CMB power spectrum. The measurements of these higher-order peaks provide an additional test of the ΛCDM cosmological model. At l>3000, we detect power in excess of the primary anisotropy spectrum of the CMB. At lower multipoles 500 < l < 3000, we find evidence for gravitational lensing of the CMB in the power spectrum at the 2.8σ level. We also detect a low level of Galactic dust in our maps, which demonstrates that we can recover known faint, diffuse signals.

  6. The usefulness of dynamic O-(2-18F-fluoroethyl)-L-tyrosine PET in the clinical evaluation of brain tumors in children and adolescents

    DEFF Research Database (Denmark)

    Dunkl, Veronika; Cleff, Corvin; Stoffels, Gabriele;

    2015-01-01

    UNLABELLED: Experience regarding O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET in children and adolescents with brain tumors is limited. METHODS: Sixty-nine (18)F-FET PET scans of 48 children and adolescents (median age, 13 y; range, 1-18 y) were analyzed retrospectively. Twenty-six scans...... after injection, and time-activity curves of (18)F-FET uptake were assigned to 3 different patterns: constant increase; peak at greater than 20-40 min after injection, followed by a plateau; and early peak (≤ 20 min), followed by a constant descent. The diagnostic accuracy of (18)F-FET PET was assessed...... predictive value, 90%; P = 0.02). During chemotherapy, a decrease of TBRs was associated with a stable clinical course, and in 2 patients PET detected residual tumor after presumably complete tumor resection. CONCLUSION: Our findings suggest that (18)F-FET PET can add valuable information for clinical...

  7. All-solid-state dual end pumped YVO4:Nd/LBO blue laser with 21.8 W output power at 457 nm

    Science.gov (United States)

    Ling, Zhao; Yi, Yao; Yang, Zhao; Quan, Zheng

    2014-03-01

    It is reported the efficient compact deep-blue laser at 457 nm generation by intracavity frequency doubling of a continuous wave (CW) laser operation of a diode-pumped YVO4:Nd laser on the 4 F 3/2 → 4 I 9/2 transition at 914 nm. An LBO crystal, cut for critical type I phase matching at room temperature is used for second harmonic generation (SHG) of the laser. With dual end pump configurations at total incident pump power of 60 W, as high as 21.8 W of CW output power at 457 nm is achieved with 20-mm-long LBO. The optical-to-optical conversion efficiency is up to 36.3%, and the power stability in 8 h is better than 2.36%.

  8. 2-[18F]fluoro-2-deoxyglucose positron-emission tomography in staging, response evaluation, and treatment planning of lymphomas

    DEFF Research Database (Denmark)

    Specht, Lena

    2007-01-01

    2-[18F]fluoro-2-deoxyglucose positron-emission tomography (FDG-PET) is used increasingly in the clinical management of lymphomas. With regard to staging, FDG-PET is more sensitive and specific than conventional staging methods in FDG avid lymphomas (ie, Hodgkin lymphoma and most aggressive non-Hodgkin...... with the planning computed tomography (CT) scan is used increasingly. The availability of PET/CT scanners suited for virtual simulation has aided this process. However, clinical data evaluating this technique are at present sparse....... lymphomas). Despite methodological problems, in particular the lack of a valid reference test, FDG-PET is approved and generally used for this purpose. With regard to response evaluation, FDG-PET at the end of treatment seems to aid considerably in differentiating between residual masses with or without...

  9. Continuous monitoring α-activity on aerosol filters by the pseudo-coincidence-technique. Explicitly taking into account the short lived Po-218 activity; Kontinuierliche Ueberwachung der α-Aktivitaet eines Aerosolfilters mit der Pseudokoinzidenzmesstechnik. Explizite Beruecksichtigung der kurzlebigen Po-218 Aktivitaetsbeitraaege

    Energy Technology Data Exchange (ETDEWEB)

    Kraut, W.; Schwarz, W. [Duale Hochschule Baden-Wuerttemberg (DHBW), Karlsruhe (Germany). Studiengang Sicherheitswesen; Kraut, B. [Berthold Technologies GmbH und Co.KG, Bad Wildbad (Germany)

    2015-07-01

    Pseudo-coincidence-technique is applied to continuous monitoring of α-activity on aerosolfilters by proportional counters. Filter activity can markedly increase or decrease by changing air conditions especially by the amount of short lived Po-218 activity. Conditions of constant proportions of activity concentrations for the short lived species for operating this technique are seldom fulfilled. The dynamic behavior of artificial (long lived) and natural (short lived) activity is mathematically modelled and the measured moving count rates are analyzed under this model by a multivariate regression analysis for activity concentrations of artificial resp. short lived activity. Results are compared to standard recommendations of DIN ISO 11929.

  10. Cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans.

    Directory of Open Access Journals (Sweden)

    Dania eVecchia

    2015-02-01

    Full Text Available Familial hemiplegic migraine type 1 (FHM1 is caused by gain-of-function mutations in CaV2.1 (P/Q-type Ca2+ channels. Knockin (KI mice carrying the FHM1 R192Q missense mutation show enhanced cortical excitatory synaptic transmission at pyramidal cell synapses but unaltered cortical inhibitory neurotransmission at fast-spiking interneuron synapses. Enhanced cortical glutamate release was shown to cause the facilitation of cortical spreading depression (CSD in R192Q KI mice. It, however, remains unknown how other FHM1 mutations affect cortical synaptic transmission. Here, we studied neurotransmission in cortical neurons in microculture from KI mice carrying the S218L mutation, which causes a severe FHM syndrome in humans and an allele-dosage dependent facilitation of experimental CSD in KI mice, which is larger than that caused by the R192Q mutation. We show gain-of-function of excitatory neurotransmission, due to increased action-potential evoked Ca2+ influx and increased probability of glutamate release at pyramidal cell synapses, but unaltered inhibitory neurotransmission at multipolar interneuron synapses in S218L KI mice. In contrast with the larger gain-of-function of neuronal CaV2.1 current in homozygous than heterozygous S218L KI mice, the gain-of-function of evoked glutamate release, the paired-pulse ratio and the Ca2+ dependence of the EPSC were all similar in homozygous and heterozygous S218L KI mice, suggesting compensatory changes in the homozygous mice. Furthermore, we reveal a unique feature of S218L KI cortical synapses which is the presence of a fraction of mutant CaV2.1 channels being open at resting potential. Our data suggest that, while the gain-of-function of evoked glutamate release may explain the facilitation of CSD in heterozygous S218L KI mice, the further facilitation of CSD in homozygous S218L KI mice is due to other CaV2.1-dependent mechanisms, that likely include Ca2+ influx at voltages sub-threshold for action

  11. Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans.

    Science.gov (United States)

    Vecchia, Dania; Tottene, Angelita; van den Maagdenberg, Arn M J M; Pietrobon, Daniela

    2015-01-01

    Familial hemiplegic migraine type 1 (FHM1) is caused by gain-of-function mutations in CaV2.1 (P/Q-type) Ca(2+) channels. Knockin (KI) mice carrying the FHM1 R192Q missense mutation show enhanced cortical excitatory synaptic transmission at pyramidal cell synapses but unaltered cortical inhibitory neurotransmission at fast-spiking interneuron synapses. Enhanced cortical glutamate release was shown to cause the facilitation of cortical spreading depression (CSD) in R192Q KI mice. It, however, remains unknown how other FHM1 mutations affect cortical synaptic transmission. Here, we studied neurotransmission in cortical neurons in microculture from KI mice carrying the S218L mutation, which causes a severe FHM syndrome in humans and an allele-dosage dependent facilitation of experimental CSD in KI mice, which is larger than that caused by the R192Q mutation. We show gain-of-function of excitatory neurotransmission, due to increased action-potential evoked Ca(2+) influx and increased probability of glutamate release at pyramidal cell synapses, but unaltered inhibitory neurotransmission at multipolar interneuron synapses in S218L KI mice. In contrast with the larger gain-of-function of neuronal CaV2.1 current in homozygous than heterozygous S218L KI mice, the gain-of-function of evoked glutamate release, the paired-pulse ratio and the Ca(2+) dependence of the excitatory postsynaptic current were similar in homozygous and heterozygous S218L KI mice, suggesting compensatory changes in the homozygous mice. Furthermore, we reveal a unique feature of S218L KI cortical synapses which is the presence of a fraction of mutant CaV2.1 channels being open at resting potential. Our data suggest that, while the gain-of-function of evoked glutamate release may explain the facilitation of CSD in heterozygous S218L KI mice, the further facilitation of CSD in homozygous S218L KI mice is due to other CaV2.1-dependent mechanisms, that likely include Ca(2+) influx at voltages sub

  12. Pertussis Toxin Exploits Host Cell Signaling Pathways Induced by Meningitis-Causing E. coli K1-RS218 and Enhances Adherence of Monocytic THP-1 Cells to Human Cerebral Endothelial Cells

    Science.gov (United States)

    Starost, Laura Julia; Karassek, Sascha; Sano, Yasuteru; Kanda, Takashi; Kim, Kwang Sik; Dobrindt, Ulrich; Rüter, Christian; Schmidt, Marcus Alexander

    2016-01-01

    Pertussis toxin (PTx), the major virulence factor of the whooping cough-causing bacterial pathogen Bordetella pertussis, permeabilizes the blood–brain barrier (BBB) in vitro and in vivo. Breaking barriers might promote translocation of meningitis-causing bacteria across the BBB, thereby facilitating infection. PTx activates several host cell signaling pathways exploited by the neonatal meningitis-causing Escherichia coli K1-RS218 for invasion and translocation across the BBB. Here, we investigated whether PTx and E. coli K1-RS218 exert similar effects on MAPK p38, NF-κB activation and transcription of downstream targets in human cerebral endothelial TY10 cells using qRT-PCR, Western blotting, and ELISA in combination with specific inhibitors. PTx and E. coli K1-RS218 activate MAPK p38, but only E. coli K1-RS218 activates the NF-κB pathway. mRNA and protein levels of p38 and NF-κB downstream targets including IL-6, IL-8, CxCL-1, CxCL-2 and ICAM-1 were increased. The p38 specific inhibitor SB203590 blocked PTx-enhanced activity, whereas E. coli K1-RS218’s effects were inhibited by the NF-κB inhibitor Bay 11-7082. Further, we found that PTx enhances the adherence of human monocytic THP-1 cells to human cerebral endothelial TY10 cells, thereby contributing to enhanced translocation. These modulations of host cell signaling pathways by PTx and meningitis-causing E. coli support their contributions to pathogen and monocytic THP-1 cells translocation across the BBB. PMID:27754355

  13. Pertussis Toxin Exploits Host Cell Signaling Pathways Induced by Meningitis-Causing E. coli K1-RS218 and Enhances Adherence of Monocytic THP-1 Cells to Human Cerebral Endothelial Cells

    Directory of Open Access Journals (Sweden)

    Laura Julia Starost

    2016-10-01

    Full Text Available Pertussis toxin (PTx, the major virulence factor of the whooping cough-causing bacterial pathogen Bordetella pertussis, permeabilizes the blood–brain barrier (BBB in vitro and in vivo. Breaking barriers might promote translocation of meningitis-causing bacteria across the BBB, thereby facilitating infection. PTx activates several host cell signaling pathways exploited by the neonatal meningitis-causing Escherichia coli K1-RS218 for invasion and translocation across the BBB. Here, we investigated whether PTx and E. coli K1-RS218 exert similar effects on MAPK p38, NF-κB activation and transcription of downstream targets in human cerebral endothelial TY10 cells using qRT-PCR, Western blotting, and ELISA in combination with specific inhibitors. PTx and E. coli K1-RS218 activate MAPK p38, but only E. coli K1-RS218 activates the NF-κB pathway. mRNA and protein levels of p38 and NF-κB downstream targets including IL-6, IL-8, CxCL-1, CxCL-2 and ICAM-1 were increased. The p38 specific inhibitor SB203590 blocked PTx-enhanced activity, whereas E. coli K1-RS218’s effects were inhibited by the NF-κB inhibitor Bay 11-7082. Further, we found that PTx enhances the adherence of human monocytic THP-1 cells to human cerebral endothelial TY10 cells, thereby contributing to enhanced translocation. These modulations of host cell signaling pathways by PTx and meningitis-causing E. coli support their contributions to pathogen and monocytic THP-1 cells translocation across the BBB.

  14. Low-Level Burial Grounds dangerous waste permit application: Request for exemption from lined trench requirements and from land disposal restrictions for residual liquid at 218-E-12B Burial Ground Trench 94

    International Nuclear Information System (INIS)

    This document has been prepared and is being submitted to the respective agencies to satisfy three objectives of the US Department of Energy (DOE) Richland Field Office (DOE-RL) concerning Trench 94 of the 218-E-12B Burial Ground. The 218-E-12B Burial Ground is located in the 200 East Area of the Hanford Facility. Figure 1-1 shows the general location of the Hanford Site. The 218-E-12B Burial Ground is one of eight burial grounds included in the Low-Level Burial Grounds (LLBG), a treatment, storage and/or disposal (TSD) unit. Decommissioned, defueled naval submarine reactor compartments (SRCs) contain radioactivity caused by exposure of structural components to neutrons during normal operation of the submarines. After all the alternatives were evaluated in the US Department of the Navy 1984 environmental impact statement (EIS) (USN 1984), land burial of the SRCs was selected as the preferred disposal option. The SRCs currently are sent to Trench 94 of the 218-E-12B Burial Ground. In addition to radioactivity, the SRCs disposed in. The DOE-RL's three objectives in preparing and submitting this document are as follows. Request from Ecology an exemption from dangerous waste landfill liner and leachate collection and removal system (hereinafter referred to as liner/leachate system) requirements for Trench 94 of the 218-E-12B Burial Ground. Petition Ecology to exempt residual liquid in the SRCs from land disposal restrictions. Obtain EPA Region 10 review and comment on the request to Ecology for exemption from liner/leachate system requirements

  15. The Ks-band Tully–Fisher Relation – A Determination of the Hubble Parameter from 218 ScI Galaxies and 16 Galaxy Clusters

    Indian Academy of Sciences (India)

    David G. Russell

    2009-06-01

    The value of Hubble parameter (H0) is determined using the morphologically type dependent Ks-band Tully–Fisher Relation (K-TFR). The slope and zero point are determined using 36 calibrator galaxies with ScI morphology. Calibration distances are adopted from direct Cepheid distances, and group or companion distances derived with the Surface Brightness Fluctuation Method or Type Ia Supernova. It is found that a small morphological type effect is present in the K-TFR such that ScI galaxies are more luminous at a given rotational velocity than Sa/Sb galaxies and Sbc/Sc galaxies of later luminosity classes. Distances are determined to 16 galaxy clusters and 218 ScI galaxies with minimum distances of 40.0 Mpc. From the 16 galaxy clusters a weighted mean Hubble parameter of H0 = 84.2 ± 6 km s-1 Mpc-1 is found. From the 218 ScI galaxies a Hubble parameter of H0 = 83.4 ± 8 km s-1 Mpc-1 is found. When the zero point of K-TFR is corrected to account for recent results that find a Large Magellanic Cloud distance modulus of 18.39 × 0.05, a Hubble parameter of 88.0 ± 6 km s-1 Mpc-1 is found. Effects from Malmquist bias are shown to be negligible in this sample as galaxies are restricted to a minimum rotational velocity of 150 km s-1. It is also shown that the results of this study are negligibly affected by the adopted slope for the K-TFR, inclination binning, and distance binning. A comparison with the results of the Hubble Key Project (Freedman et al. 2001) is made. Discrepancies between the K-TFR distances and the HKP I-TFR distances are discussed. Implications for -CDM cosmology are considered with H0 = 84 km s-1 Mpc-1. It is concluded that it is very difficult to reconcile the value of H0 found in this study with ages of the oldest globular clusters and matter density of the universe derived from galaxy clusters in the context of -CDM cosmology.

  16. Titan's surface at 2.18-cm wavelength imaged by the Cassini RADAR radiometer: Results and interpretations through the first ten years of observation

    Science.gov (United States)

    Janssen, M. A.; Le Gall, A.; Lopes, R. M.; Lorenz, R. D.; Malaska, M. J.; Hayes, A. G.; Neish, C. D.; Solomonidou, A.; Mitchell, K. L.; Radebaugh, J.; Keihm, S. J.; Choukroun, M.; Leyrat, C.; Encrenaz, P. J.; Mastrogiuseppe, M.

    2016-05-01

    A comprehensive calibration and mapping of the thermal microwave emission from Titan's surface is reported based on radiometric data obtained at 2.18-cm wavelength by the passive radiometer included in the Cassini RADAR instrument. Compared to previous work, the present results incorporate the much larger data set obtained in the approximately ten years following Saturn Orbit Insertion. Brightness temperature data including polarization were accumulated by segments in Titan passes from Ta (October 2004) through T98 (February 2014). The observational segments were analyzed to produce a mosaic of effective dielectric constant based on the measurement of thermal polarization covering 76% of the surface, and brightness temperature at normal incidence covering Titan's entire surface. As part of the mosaicking process we also solved for the seasonal variation of physical temperature with latitude, which we found to be smaller by a factor of 0.87 ± 0.05 in relative amplitude compared to that reported in the thermal infrared by Cassini's Composite Infrared Spectrometer (CIRS). We used the equatorial temperature obtained by the Huygens probe and the seasonal dependence with latitude from CIRS to convert the brightness mosaic to absolute emissivity, from which we could infer global thermophysical properties of the surface in combination with the dielectric mosaic. We see strong evidence for subsurface (volume) scattering as a dominant cause of the radar reflectivity in bright regions, and elsewhere a surface composition consistent with the slow deposition and processing of organic compounds from the atmosphere. The presence of water ice in the near subsurface is strongly indicated by the high degree of volume scattering observed in radar-bright regions (e.g., Hummocky/mountainous terrains) constituting ∼10% of Titan's surface. A thermal analysis allowed us to infer a mean 2.18-cm emission depth in the range 40-100 cm for the dominant radar-dark terrains (the remainder of

  17. Association of trytophan hydroxylase gone A218C and serotonin transporter gone polymorphism with essential hypertension in Chinese northern Hart population%色氨酸羟化酶基因A218C及5-羟色胺转运体基因多态性与原发性高血压

    Institute of Scientific and Technical Information of China (English)

    夏大胜; 卢成志; 郭倩玉; 宋衍秋; 李超; 徐建强; 张峰

    2009-01-01

    Objective To investigate the relationship between trytophan hydroxylase (TPH) gene A218C in intren 7 and 5-hydroxytryptamine transporter (5-HTT) gene variable number tandem repeat (VNTR) in intron 2 and gene-linked polymorphic region (LPR) deletion/iusertion polymorphism and essential hypertension (EH) in Chinese northern Han population.Methods A total of 280 EH patients and 200 normoteusive controls were genotyped using polymerase chain reaction-restriction fragment length polymorphism technique.Results There were no significant differences in the frequencies of the genotypes and alleles of TPH gene A218C and 5-HTTVNTR between EH patents and controls (all P > 0.05).The genotype frequencies of SS,LS and LL in the 5-HTTLPR polymorphism was 68%,29% and 3% in EH patients,53% ,37% and 10% in the controls respectively (P 0.05).5-HTTLPR多态的SS、LS及LL基因型在EH组分布频率为68%,29%,3%,在对照组分别为53%,37%和10%(P<0.01);S、L等位基因在EH组分布频率为82%和18%,在对照组分别为72%和28%(P<0.01).与L等位基因携带者(LS+LL)相比,SS纯合子EH患病风险显著增加(OR=1.90,95%CI为1.31~2.77,P=0.001).logistic回归分析校正年龄、性别、体质指数、血脂、空腹血糖及血尿酸水平,5-HTTLPR多态SS基因型仍与EH发病危险显著相关(DR=1.47,95%CI为1.06~2.04,P=0.021).结论 5-HTTLPR的SS基因型可能与中国北方汉族人群EH的发生相关联,而TPH基因A218C和5-HTTVNTR基因多态性在中国北方汉族人群EH的发生不起主要作用.

  18. Synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine and its biological evaluation in B16 melanoma-bearing mice as PET tracer for tumor imaging

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    O-(2-[18F]fluoroethyl) -L-tyrosine([18F]FET) ,a fluorine-18 labeled analogue of tyrosine,has been syn-thesized and biologically evaluated in tumor-bearing mice. The whole synthesis procedure is com-pleted within 50 min. The radiochemical yield is about 40%(no decay corrected) and radiochemical purity more than 97% after simplified solid phase extraction. [18F]FET shows rapid,high uptake and long retention in the tumor as well as low uptake in the brain. The ratios of tumor-to-muscle(T/M) and tumor-to-blood(T/B) of [18F]FET are similar to those of [18F]FDG,but the ratios of tumor-to-brain(T/Br) are 2-3 times higher than that of [18F]FDG. Autoradiography of [18F]FET demonstrates a remarkable accumulation in melanoma with high contrast. It appears to be a probable competitive candidate for melanoma imaging with PET.

  19. Synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine and its biological evaluation in B16 melanoma-bearing mice as PET tracer for tumor imaging

    Institute of Scientific and Technical Information of China (English)

    WANG MingWei; YIN DuanZhi; LI ShiQiang; WANG YongXian

    2007-01-01

    O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), a fluorine-18 labeled analogue of tyrosine, has been synthesized and biologically evaluated in tumor-bearing mice. The whole synthesis procedure is completed within 50 min. The radiochemical yield is about 40% (no decay corrected) and radiochemical purity more than 97% after simplified solid phase extraction. [18F]FET shows rapid, high uptake and long retention in the tumor as well as low uptake in the brain. The ratios of tumor-to-muscle (T/M) and tumor-to-blood (T/B) of [18F]FET are similar to those of [18F]FDG, but the ratios of tumor-to-brain (T/Br)are 2-3 times higher than that of [18F]FDG. Autoradiography of [18F]FET demonstrates a remarkable accumulation in melanoma with high contrast. It appears to be a probable competitive candidate for melanoma imaging with PET.

  20. Preliminary Thermal Modeling of Hi-Storm 100S-218 Version B Storage Modules at Hope Creek Nuclear Power Station ISFSI

    Energy Technology Data Exchange (ETDEWEB)

    Cuta, Judith M.; Adkins, Harold E.

    2013-08-30

    This report fulfills the M3 milestone M3FT-13PN0810022, “Report on Inspection 1”, under Work Package FT-13PN081002. Thermal analysis is being undertaken at Pacific Northwest National Laboratory (PNNL) in support of inspections of selected storage modules at various locations around the United States, as part of the Used Fuel Disposition Campaign of the U.S. Department of Energy, Office of Nuclear Energy (DOE-NE) Fuel Cycle Research and Development. This report documents pre-inspection predictions of temperatures for four modules at the Hope Creek Nuclear Generating Station ISFSI that have been identified as candidates for inspection in late summer or early fall/winter of 2013. These are HI-STORM 100S-218 Version B modules storing BWR 8x8 fuel in MPC-68 canisters. The temperature predictions reported in this document were obtained with detailed COBRA-SFS models of these four storage systems, with the following boundary conditions and assumptions.

  1. Early Treatment Response Monitoring Using 2-Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography Imaging during Fractionated Radiotherapy of Head Neck Cancer Xenografts

    Directory of Open Access Journals (Sweden)

    Jiayi Huang

    2014-01-01

    Full Text Available Background. To determine the optimal timing and analytic method of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (PET imaging during fractionated radiotherapy (RT to predict tumor control. Methods. Ten head neck squamous cell carcinoma xenografts derived from the UT-14-SCC cell line were irradiated with 50 Gy at 2 Gy per day over 5 weeks. Dynamic PET scans were acquired over 70 minutes at baseline (week 0 and weekly for seven weeks. PET data were analyzed using standard uptake value (SUV, retention index (RI, sensitivity factor (SF, and kinetic index (Ki. Results. Four xenografts had local failure (LF and 6 had local control. Eighty scans from week 0 to week 7 were analyzed. RI and SF after 10 Gy appeared to be the optimal predictors for LF. In contrast, SUV and Ki during RT were not significant predictors for LF. Conclusion. RI and SF of PET obtained after the first week of fractionated RT were the optimal methods and timing to predict tumor control.

  2. Functional analysis of three amino acid residues of purR re-pressor, Trp147, Gln-218 and Gln-292 in Salmonella typhi-murium

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The amber mutation sites of 6 purR(am) mutants were determined bycloning and DNA sequencing. The results showed that the mutations were distributed at three different sites in PurR coding region, G721(→A), C933(→T) and C1155(→T), which respectively turn Trp-147,Gln-218 and Gln-292 of PurR into TAG terminal codon. To determine the effect of the three amino acid residues on regulatory function of PurR protein 5 different kinds of tRNA suppressor genes, Su3, Su4, Su6, Su7 and Su9 were used for creating the PurR protein variants with single amino acid substitution. The results indicated that Cys, Glu, Gly, His and Arg which substituted Trp-147 respectively all could not recover the regulation function of PurR. It confirmed that Trp-147 is a critical amino acid for the PurR function. Gln-292 substituted respectively by the same amino acids also could not recover the PurR function, demonstrating that Gln-292 is also an important amino acid residue in PurR.

  3. Line position and line intensity analyses of the high-resolution spectrum of H218O up to the First Triad and J = 17

    Science.gov (United States)

    Coudert, L. H.; Chelin, P.

    2016-08-01

    Line position and line intensity analyses of the high-resolution spectrum of the H218O isotopic species of the water molecule are performed with the Bending-Rotation approach up to J = 17 and the First Triad of interacting states, (0 2 0), (1 0 0), and (0 0 1). The line position analysis involves microwave and terahertz transitions, ground state combination differences, far infrared and infrared lines, and experimental energy levels which were reproduced with a 1.2 unitless standard deviation. The data set considered in the line intensity analysis consists of 3707 infrared transitions recorded using absorption spectroscopy at room temperature which were fitted with a 1.4 unitless standard deviation. The results of both analyses are compared with previous investigations and are used to build a line position and line intensity database to update the HITRAN and GEISA databases. A comparison with the HITRAN 2012 database reveals that the new database yields intensity values closer to the experimental ones.

  4. Asociation between hydroxylase gene A218C polymorphism and anger started as well as anger expression trait%色氨酸羟化酶基因A218C多态性与愤怒启动及表达特质的关系

    Institute of Scientific and Technical Information of China (English)

    詹向红; 侯俊林; 闫秀娟; 刘永; 李伟; 闫国立; 王友杰; 杨丽萍

    2013-01-01

    目的:探讨色氨酸羟化酶(TPH)基因A218C多态性与愤怒启动及表达特质的关系.方法:用状态特质愤怒表达量表2(STAXI-2)筛选受试者,经采血、酚-氯仿法提取DNA、PCR-LDR法基因分型后,对数据进行统计分析.结果:①高、低特质怒两组中,基因型及等位基因频率分布差异无统计学意义.②高特质怒被试3个基因型组以下得分差异有统计学意义(P<0.05,P<0.01):发怒(AX-O),女性怒的表达(AX),男性郁怒(AX-I).③低特质怒被试3个基因型组AX-I得分差异有统计学意义(P<0.05).结论:TPH基因A218C多态性与中国正常大学生中高特质怒者的发怒特质、高特质怒女性怒的表达特质、高特质怒男性郁怒特质有关,还与低特质怒者的郁怒特质有关.%Objective:To discuss the association of tryptophan hydroxylase gene A218C polymorphism and anger started as well as anger expression trait.Methods:After the subjects were selected by STAXI-2 questionnaire,blood of them was sampled,DNA was extracted by phenol-chloroform method,genotyping by PCR-LDR method,and data was statistically analyzed.Results:①There was no statistical significance of genotype and the allele frequency distribution of the subjects between the high and low trait anger groups.②For high trait anger subjects,there was statistical significance of the following scores of the subjects in three genotype groups (P<0.05):anger expression-out (AX-O),anger expression (AX) of female,anger expression-in (AX-I) of male.③For low trait anger subjects,there was statistical significance of the scores of anger expression-in of the subjects in three genotype groups (P<0.05).Conclusion:There was the association of TPH gene A218C polymorphism with the following anger traits of normal college students with high trait anger in China:anger expression-out trait,anger expression trait of female,anger expression-in trait of male.The locus polymorphlsm was also related to the anger

  5. Documentation associated with the shipping of Hot-Cell Waste from WESF 225-B to the 200W (218-W-3AE) burial grounds under shipment number RSR-37338

    International Nuclear Information System (INIS)

    The purpose of this report is to compile the records generated during the Packaging and Shipping of WESF Hot-Cell Waste from the 225-B Facility to 200W (218-W-3AE) burial grounds. A total of six 55-gallon drums were packaged and shipped using the Chem-Nuc Cask in accordance with WHC-SD-TP-SARP-025, Rev.0 ''Safety Analysis Report for Packaging (Onsite) for Type B Material in the CNS-14-215H Cask''

  6. Phase structure and hydrogen storage properties of REMg8.35Ni2.18Al0.21 (RE=La, Ce, Pr, and Nd) hydrogen storage alloys

    Institute of Scientific and Technical Information of China (English)

    刘岩青; 韩树民; 扈琳; 刘宝忠; 赵鑫; 贾彦虹

    2013-01-01

    REMg8.35Ni2.18Al0.21 (RE=La, Ce, Pr, and Nd) alloys were prepared by induction melting and following annealing. X-ray diffraction (XRD) and scanning electron microscopy (SEM) results showed that the alloys were composed of Mg2Ni, (La, Pr, Nd)Mg2Ni, (La, Ce)2Mg17, (Ce, Pr, Nd)Mg12 and Ce2Ni7 phases. The above phases were disproportioned into Mg2NiH4, MgH2 and REHx (x=2.51 or 3) phases in hydriding. CeH2.51 phase transformed into CeH2.29 phase in dehydriding, whereas LaH3, PrH3 and NdH3 phases re-mained unchanged. The PrMg8.41Ni2.14Al0.20 alloy had the fastest hydriding kinetics and the highest dehydriding plateau pressure while the CeMg8.35Ni2.18Al0.21 alloy presented the best hydriding/dehydriding reversibility. The onset hydrogen desorption tempera-ture of the CeMg8.35Ni2.18Al0.21 hydride decreased remarkably owing to the phase transformation between the CeH2.51 and the CeH2.29.

  7. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.

    Directory of Open Access Journals (Sweden)

    Tuomas O Kilpeläinen

    2011-11-01

    Full Text Available The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166 and nine studies of children and adolescents (n = 19,268.All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2>0.8] and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A- allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26, but PA attenuated this effect (p(interaction  = 0.001. More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio  = 1.22/allele, 95% CI 1.19-1.25 than in the inactive group (odds ratio  = 1.30/allele, 95% CI 1.24-1.36. No such interaction was found in children and adolescents.The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.

  8. Evaluation of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in rat models with hepatocellular carcinoma with liver cirrhosis.

    Science.gov (United States)

    Park, S I; Lee, J H; Ham, H J; Jung, Y J; Park, M S; Lee, J; Maeng, L S; Chung, Y A; Jang, K S

    2015-01-01

    Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). However, the exact mechanism of the progression from cirrhosis to cancer remains unclear. The uptake of 2-[(18)F]-fluoro-2-deoxy-D-glucose ((18)F-FDG) is widely used as a marker of increased glucose metabolism to monitor the progression of cancer with positron emission tomography (PET)/computed tomography (CT). Here we investigated the feasibility of using (18)F-FDG PET/CT in the diethylnitrosamine (DEN) mediated experimental hepatocellular carcinoma model. Rats received weekly intraperitoneal injections of DEN for 16 weeks for induction of HCC. We recorded starting from 0 days or 0 weeks after the last DEN injection. The weight and survival rate of rats were then measured. Also, an (18)F-FDG PET scan and serum analysis were performed at minus 2, 0, plus 2, and plus 4 weeks after the last DEN injection. The body weight of rats was maintained between 350 g and 370 g during 14 and 20 weeks, and the rats were euthanized at 35 days after the last DEN injection. The serum levels of alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphate (ALP) were significantly higher at zero weeks after the last DEN injection. The (18)F-FDG uptake for the quantitative evaluation of HCC was done by measuring the region of interest (ROI). At minus two weeks after the last DEN injection, the ROI of rats had significantly increased compared to the normal group, in a time-dependent manner. These results suggest that FDG uptake serves as a good screening test to evaluate the feasibility of DEN-induced HCC. PMID:26405933

  9. Sick-leave track record and other potential predictors of a disability pension. A population based study of 8,218 men and women followed for 16 years

    Directory of Open Access Journals (Sweden)

    Rosengren Annika

    2009-04-01

    Full Text Available Abstract Background A number of previous studies have investigated various predictors for being granted a disability pension. The aim of this study was to test the efficacy of sick-leave track record as a predictor of being granted a disability pension in a large dataset based on subjects sampled from the general population and followed for a long time. Methods Data from five ongoing population-based Swedish studies was used, supplemented with data on all compensated sick leave periods, disability pensions granted, and vital status, obtained from official registers. The data set included 8,218 men and women followed for 16 years, generated 109,369 person years of observation and 97,160 sickness spells. Various measures of days of sick leave during follow up were used as independent variables and disability pension grant was used as outcome. Results There was a strong relationship between individual sickness spell duration and annual cumulative days of sick leave on the one hand and being granted a disability pension on the other, among both men and women, after adjustment for the effects of marital status, education, household size, smoking habits, geographical area and calendar time period, a proxy for position in the business cycle. The interval between sickness spells showed a corresponding inverse relationship. Of all the variables studied, the number of days of sick leave per year was the most powerful predictor of a disability pension. For both men and women 245 annual sick leave days were needed to reach a 50% probability of transition to disability. The independent variables, taken together, explained 96% of the variation in disability pension grantings. Conclusion The sick-leave track record was the most important predictor of the probability of being granted a disability pension in this study, even when the influences of other variables affecting the outcome were taken into account.

  10. Positron Emission Tomography with 2-Deoxy-2-[18F] Fluoro-DGlucose in the Detection of Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas

    Directory of Open Access Journals (Sweden)

    Brian KP Goh

    2007-05-01

    Full Text Available A 79-year-old Indian male was admitted with upper abdominal discomfort of 1-year duration which was associated with loss of weight and appetite. Clinical examination of the abdomen did not reveal any palpable masses. Laboratory investigations including a complete blood count, liver function tests and serum amylase were unremarkable. Standard serum tumor markers were within normal limits: carbohydrate antigen (CA 19-9, 13.4 U/mL (reference range: 3-45 U/mL; carcinoembryonic antigen (CEA, 1.4 μg/L (reference range: 0.5-3.5 μg/L and alphafetoprotein, 1.3 μg/L (reference range: 1-10 μg/L. A contrast-enhanced computed tomographic (CT scan demonstrated a cystically dilated and tortuous pancreatic duct measuring 1.9 cm, suggestive of an intraductal papillary mucinous neoplasm (IPMN. The common bile duct was dilated up to the level of the ampulla and a 3.2x2.0 cm heterogeneous soft tissue mass was observed in the head of the pancreas which extended into the duodenum, suggestive of a malignant lesion (Images 1 and 2. Fusion positron emission tomography/computed tomography (PET/CT was subsequently performed with 12.7 mCi of 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG administered intravenously. A whole body PET/CT scan was performed 60 minutes later with CT data used for attenuation correction and anatomical correlation. This confirmed a metabolically active focus within the pancreatic head mass with a standard uptake value (SUVmax of 3.5 compatible with carcinoma (Image 3.

  11. Reproducibility of O-(2-18F-fluoroethyl)-L-tyrosine uptake kinetics in brain tumors and influence of corticoid therapy: an experimental study in rat gliomas

    International Nuclear Information System (INIS)

    Positron emission tomography (PET) using O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) is a well-established method for the diagnostics of brain tumors. This study investigates reproducibility of 18F-FET uptake kinetics in rat gliomas and the influence of the frequently used dexamethasone (Dex) therapy. F98 glioma or 9L gliosarcoma cells were implanted into the striatum of 31 Fischer rats. After 10-11 days of tumor growth, the animals underwent dynamic PET after injection of 18F-FET (baseline). Thereafter, animals were divided into a control group and a group receiving Dex injections, and all animals were reinvestigated 2 days later. Tumor-to-brain ratios (TBR) of 18F-FET uptake (18-61 min p.i.) and the slope of the time-activity-curves (TAC) (18-61 min p.i.) were evaluated using a Volume-of-Interest (VOI) analysis. Data were analyzed by two-way repeated measures ANOVA and reproducibility by the intraclass correlation coefficient (ICC). The slope of the tumor TACs showed high reproducibility with an ICC of 0.93. A systematic increase of the TBR in the repeated scans was noted (3.7 ± 2.8 %; p < 0.01), and appeared to be related to tumor growth as indicated by a significant correlation of TBR and tumor volume (r = 0.77; p < 0.0001). After correction for tumor growth TBR showed high longitudinal stability with an ICC of 0.84. Dex treatment induced a significant decrease of the TBR (-8.2 ± 6.1 %; p < 0.03), but did not influence the slope of the tumor TAC. TBR of 18F-FET uptake and tracer kinetics in brain tumors showed high longitudinal stability. Dex therapy may induce a minor decrease of the TBR; this needs further investigation. (orig.)

  12. Intraoperative cardiac arrest during anesthesia:a retrospective study of 218 274 anesthetics undergoing non-cardiac surgery in a US teaching hospital

    Institute of Scientific and Technical Information of China (English)

    AN Jian-xiong; Li-Ming Zhang; Erin A.Sullivan; GUO Qu-lian; John P.Williams

    2011-01-01

    Background Patient safety has been gained much more attention in recent years.The authors reviewed patients who had cardiac arrest in the operating rooms undergoing noncardiac surgery between January 1989 and December 2001 at the University of Pittsburgh Medical Center,USA.The main objectives of the study were to determine the incidence of intraoperative cardiac arrest,to identify possible causes of cardiac arrest and to explore amenable modifications.Methods With approval by the University of Pittsburgh Institutional Review Board,patients experienced cardiac arrest during surgery were retrieved from medical records,surgical operation and anesthesia records and pathological reports by searching the Medical Archival Retrieval System (MARS),a hospital electronic searching system.Cases of cardiac arrest were collected over a period of thirteen years from the Pre byteria University Hospital (PUH),USA.Results We found 23 cases of intraoperative cardiac arrests occurred in 218 274 anesthesia cases (1.1 per 10 000).Fourteen patients (60.8%) died in the operating room,leading to a mortality rate from all causes of 0.64 per 10 000 anesthetics.Immediate overall survival rate after arrest was 39% (9/23).Half of the patients (12/23) were emergency cases with 41% survival rate (5/12).One fourth of the arrests were trauma patients (6/23).Most arrest patients (87%,20/23) were American Society of Anesthesiologists Physical Status (ASA PS) Ⅳ and Ⅴ,while only three patients were ASA PS-Ⅰ,Ⅱ and Ⅲ,respectively.One case was attributable to an anesthesia-related cardiac arrest and recovered after successful resuscitation.Conclusions Most intraoperative cardiac arrests were not due to anesthesia-related causes.Anesthesia-related cardiac arrests might have a higher survival rate when compared to other possible causes of cardiac arrest in the operating room.

  13. 2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography initial staging impacts on survival in Hodgkin lymphoma

    Institute of Scientific and Technical Information of China (English)

    Juliano; J; Cerci; Camila; C; G; Linardi; Luís; F; Pracchia; José; Soares; Junior; Evelinda; Trindade; Dominique; Delbeke; Rodrigo; J; Cerci; Robert; Carr; José; C; Meneghetti; Valeria; Buccheri

    2013-01-01

    AIM:To assess the prognostic value and risk classification improvement of metabolic staging(MS)with Initial2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography(FDG-PET)in initial staging of Hodgkin’s Lymphoma(HL)patients to predict 5 years overall survival(5y-OS)and event free survival(EFS).METHODS:A total of 275 patients were included in this retrospective study,155 patients were staged with conventional anatomical staging(AS),and 120 also submitted to MS(FDG-PET).Prognostic analysis compared 5y-OS and 5y-EFS of patients staged with AS and MS.Risk-adjusted models incorporated clinical risk factors,computed tomography and FDG-PET staging.RESULTS:During the follow up of 267 evaluated patients,220(122 AS and 98 MS)achieved complete remission after first-line therapy(median follow-up:70±29 mo),treatment failure occurred in 79 patients and 34 died.The 5y-EFS for early vs advanced disease in AS patients was 79.3%and 66.7%,and 85.6%and53.6%in MS patients,respectively(P<0.01).The5y-OS for early and advanced disease with AS was91.3%and 81.5%,and 97.5%and 80.7%for patients staged with MS,respectively.Cox proportional hazards analysis demonstrated that FDG-PET added signifcant prognostic information and improved risk prediction(P=0.02).CONCLUSION:Initial staging FDG-PET could be used as an accurate and independent predictor of OS and EFS in HL,with impact in 5y-EFS and OS.

  14. Positron emission tomography agent 2-deoxy-2-[18F]fluoro-D-glucose has a therapeutic potential in breast cancer

    International Nuclear Information System (INIS)

    Novel approaches are needed for breast cancer patients in whom standard therapy is not effective. 2-Deoxy-2-[18F]fluoro-D-glucose (18F-FDG) was evaluated as a potential radiomolecular therapy agent in breast cancer animal models and, retrospectively, in patients with metastatic breast cancer. Polyoma middle T antigen (PyMT) and mouse mammary tumor virus-NeuT transgenic mice with tumors 0.5–1 cm in diameter were imaged with 18F-FDG, and tumor to liver ratios (TLRs) were calculated. The radiotoxicity of 18F-FDG administration was determined in healthy mice. PyMT mice with small (0.15–0.17 cm) and large (more than 1 cm) tumors were treated with 2–4 mCi of 18F-FDG, and control C3H/B6 mice with 3 mCi of 18F-FDG. At 10 days after treatment the tumors and control mammary glands were analyzed for the presence of apoptotic and necrotic cells. Five patients with breast cancer and metastatic disease were evaluated and standardized uptake values (SUVs) in tumors, maximum tolerated dose, and the doses to the tumor were calculated. Doses up to 5 mCi proved to be non-radiotoxic to normal organs. The 18F-FDG uptake in mouse tumors showed an average TLR of 1.6. The treatment of mice resulted in apoptotic cell death in the small tumors. Cell death through the necrotic pathway was seen in large tumors, and was accompanied by tumor fragmentation and infiltration with leukocytes. Normal mammary tissues were not damaged. A human 18F-FDG dose delivering 200 rad to the red marrow (less than 5% damage) was calculated to be 4.76 Ci for a 70 kg woman, and the dose to the tumors was calculated to be 220, 1100 and 2200 rad for SUVs of 1, 5 and 10, respectively. We have shown that positrons delivered by 18F-FDG to mammary tumors have a tumoricidal effect on cancer cells. The study of breast cancer patients suggests that the tumor and normal organ dosimetry of 18F-FDG makes it suitable for therapy of this malignancy

  15. Positron emission tomography with 2-[18F]-Fluoro-2-Deoxy-D-Glucose for initial staging of hodgkin lymphoma: a single center experience in Brazil

    Directory of Open Access Journals (Sweden)

    Juliano Julio Cerci

    2009-06-01

    Full Text Available BACKGROUND: 2-[18F]-Fluoro-2-Deoxy-D-Glucose (FDG-PET is a well established functional imaging modality for the initial staging of Hodgkin lymphoma (HL in patients from Western Europe and North America. The reliability of FDG-PET in populations of different ethnic groups is unclear, as all investigations published to date have come from developed countries. PURPOSE: The aim of the present study was to investigate the effectiveness of FDG-PET in the initial staging of HL patients in a Brazilian population. METHODS: Eighty-two patients with newly diagnosed HL were prospectively included in the study. All patients were staged with both conventional clinical staging (CCS methods, including computed tomography (CT and whole-body FDG-PET methods. A standard of reference for the nodal regions and the extranodal organs was determined using all available information, including the CCS methods, FDG-PET, the diagnostic histology and the follow-up examinations. The results of the CCS were then compared to the FDG-PET results. RESULTS: The sensitivity of FDG-PET was higher for nodal staging than that of CT (87.8% vs. 61.6%, respectively. FDG-PET was also more sensitive than CT in regard to evaluating the extranodal organs for lymphomatous involvement (96.2% vs. 40.0%, respectively. FDG-PET detected all 16 patients who were characterized by a positive bone marrow biopsy and identified an additional 4 patients with bone marrow disease. The incorporation of FDG-PET coupled with CCS in the staging procedure upstaged 20% (17/82 of the patients and downstaged 11% (9/82 of the patients. As a result of these changes in staging, 15% (13/82 of the patients would have received a different therapeutic regimen. CONCLUSIONS: The FDG-PET method is superior to CT for the detection of nodal and extra-nodal HL. The observation that the FDG-PET method upstaged the disease was the most common result (20% of patients brought about by the addition of PET to the staging algorithm

  16. Glacial–interglacial changes of H218O, HDO and deuterium excess – results from the fully coupled Earth System Model ECHAM5/MPI-OM

    Directory of Open Access Journals (Sweden)

    M. Werner

    2015-10-01

    Full Text Available In this study we present first results of a new isotope-enabled general circulation model setup. The model consists of a fully coupled atmosphere–ocean model ECHAM5/MPI-OM, enhanced by the interactive land surface scheme JSBACH and an explicit hydrological discharge scheme to close the global water budget. Stable water isotopes H218O and HDO have been incorporated into all relevant model components. Results of two equilibrium simulations under pre-industrial and last glacial maximum conditions are analysed and compared to observational data and paleoclimate records for evaluating the model's performance of simulating spatial and temporal variations in the isotopic composition of the Earth's water cycle. For the pre-industrial climate, many aspects of the simulation results of meteoric waters are in good to very good agreement with both observations and earlier atmosphere-only simulations. The model is capable of adequately simulating the large spread in the isotopic composition of precipitation between low and high latitudes. A comparison to available ocean data also shows a good model-data agreement, however a strong bias of too depleted ocean surface waters is detected for the Arctic region. Simulation results under last glacial maximum boundary conditions also fit to the wealth of available isotope records from polar ice cores, speleothems, as well as marine calcite data. Data-model evaluation of the isotopic composition in precipitation reveals a good match of the model results and indicates that the temporal glacial–interglacial isotope–temperature relation was substantially lower than the present spatial gradient for most mid- to high-latitudinal regions. As compared to older atmosphere-only simulations, a remarkable improvement is achieved for the modelling of the deuterium excess signal in Antarctic ice cores. Our simulation results indicate that cool sub-tropical and mid-latitudinal sea surface temperatures are key for this

  17. Investigating the impact of light and water status on the exchange of COS, 13CO2, CO18O and H218O from bryophytes

    Science.gov (United States)

    Gimeno, Teresa; Royles, Jessica; Ogee, Jerome; Jones, Samuel; Burlett, Regis; West, Jason; Sauze, Joana; Wohl, Steven; Genty, Bernard; Griffiths, Howard; Wingate, Lisa

    2016-04-01

    Terrestrial surfaces are often covered by photoautotrophic communities that play a significant role in the biological fixation of C and N at the global scale. Bryophytes (mosses, liverworts and hornworts) are key members in these communities and are especially adapted to thrive in hostile environments, by growing slowly and surviving repeated dehydration events. Consequently, bryophyte communities can be extremely long-lived (>1500yrs) and can serve as valuable records of historic climate change. In particular the carbon and oxygen isotope compositions of mosses can be used as powerful proxies describing how growing season changes in atmospheric CO2 and rainfall have changed in the distant past over the land surface. Interpreting the climate signals of bryophyte biomass requires a robust understanding of how changes in photosynthetic activity and moisture status regulate the growth and isotopic composition of bryophyte biomass. Thus theoretical models predicting how changes in isotopic enrichment and CO2 discrimination respond to dehydration and rehydration are used to tease apart climatic and isotopic source signals. Testing these models with high resolution datasets obtained from new generation laser spectrometers can provide more information on how these plants that lack stomata cope with water loss. In addition novel tracers such as carbonyl sulfide (COS) can also be measured at high resolution and precision (CO2, CO18O and H218O fluxes by a bryophyte species (Marchantia sp.) in the light and during the dark, through complete desiccation cycles. Our measurements consistently reveal a strong enrichment dynamic in the oxygen isotope composition of transpired water over the dessication cycle that caused an increase in the oxygen isotope discrimination of CO2. These data followed closely values predicted by our process-based model. We also observed a consistent pattern in the fluxes of CO2 and COS during the desiccation cycle. Initially when the bryophyte was wet

  18. Environmental Assessment and Finding of No Significant Impact: Widening Trench 36 of the 218-E-12B Low-Level Burial Ground, Hanford Site, Richland, Washington

    Energy Technology Data Exchange (ETDEWEB)

    N/A

    1999-02-11

    This environmental assessment was prepared to assess potential environmental impacts associated with the proposed action to widen and operate unused Trench 36 in the 218-E-12B Low-Level Burial Ground for disposal of low-level waste. Information contained herein will be used by the Manager, U.S. Department of Energy, Richland Operations Office, to determine if the Proposed Action is a major federal action significantly affecting the quality of the human environment. If the Proposed Action is determined to be major and significant, an environmental impact statement will be prepared. If the Proposed Action is determined not to be major and significant, a Finding of No Significant Impact will be issued and the action may proceed. Criteria used to evaluate significance can be found in Title 40, Code of Federal Regulations 1508.27. This environmental assessment was prepared in compliance with the ''National Environmental Policy Act of1969'', as amended, the Council on Environmental Quality Regulations for Implementing the Procedural Provisions of ''National Environmental Policy Act'' (Title 40, Code of Federal Regulations 1500-1508), and the U.S. Department of Energy Implementing Procedures for ''National Environmental Polio Act'' (Title 10, Code of Federal Regulations 1021). The following is a description of each section of this environmental assessment. (1) Purpose and Need for Action. This section provides a brief statement concerning the problem or opportunity the U.S, Department of Energy is addressing with the Proposed Action. Background information is provided. (2) Description of the Proposed Action. This section provides a description of the Proposed Action with sufficient detail to identify potential environmental impacts. (3) Alternatives to the Proposed Action. This section describes reasonable,alternative actions to the Proposed Action, which addresses the Purpose and Need. A No Action Alternative

  19. N-(2-18F-氟丙酰基)-L-谷氨酰胺的合成及生物学分布%Synthesis of N-(2-18F-fluoropropionyl)-L-glutamine and its biodistribution study in mice

    Institute of Scientific and Technical Information of China (English)

    唐彩华; 唐刚华; 高思远; 刘少玉; 文富华; 聂大红

    2016-01-01

    Objective To synthesize 18F labeled N-(2-18 F-fluoropropionyl)-L-glutamine (18 F-FPGLN) for tumor PET imaging,and to perform its biodistribution study on normal mice and PC-3 tumorbearing nude mice.Methods 4-nitrophenyl-2-18F-fluoropropionate (18F-NFP) was synthesized on the MF2V-IT-I synthesizer and was purified by semi-preparative HPLC.Anhydrous 18F-NFP was added to a solution of L-glutanine t-butyl ester to synthesize 18F-FPGLN t-butyl ester,which was hydrolyzed by HCl (3 mol/L) and neutralized with NaOH (2 mol/L) solution.18F-FPGLN product was collected for further study.Biodistribution study was performed on normal Kunming mice and PC-3 prostate cancer tumor-bearing nude mice,respectively.Results 18F-FPGLN was synthesized with 10%-15% (decay uncorrected) overall radiochemical yield after 130 min of radiosynthesis.The radiochemical purity was higher than 96%.Rapid and high uptake of radiotracer was observed within the kidneys,and was quickly excreted through the urinary bladder.The uptake in kidney reached (35.0±1.2) %ID/g at 5 min post-injection,and descended to (1.5±0.3) %ID/g at 120 min.The liver,lung,heart and small intestine showed relatively moderate uptake of radioactivity.The uptake in the pancreas,muscle,spleen,stomach and brain was low,and the lowest uptake of (1.5±0.3) %ID/g was found in the brain at 30 min post injection.High accumulation of 18F-FPGLN in PC-3 xenograft was observed,and the tumor/muscle ratio reached 2.07 at 60 min post injection.Conclusion A novel N-position 18F-labeled glutamine analogs 18F-FPGLN,with favorable pharmacokinetic characteristics,is synthesized successfully,which makes it possible to perform tumor PET imaging using 18F-FPGLN subsequently.%目的 合成N端标记新型肿瘤亚氨基酸类PET显像剂N-(2-18F-氟丙酰基)-L-谷氨酰胺(18F-FPGLN),并进行正常小鼠及荷PC-3前列腺癌裸鼠体内生物学分布研究.方法 首先在18F多功能合成仪中合成辅基2-18F

  20. Investigating the impact of light and water status on the exchange of COS, 13CO2, CO18O and H218O from bryophytes

    Science.gov (United States)

    Gimeno, Teresa; Royles, Jessica; Ogee, Jerome; Jones, Samuel; Burlett, Regis; West, Jason; Sauze, Joana; Wohl, Steven; Genty, Bernard; Griffiths, Howard; Wingate, Lisa

    2016-04-01

    Terrestrial surfaces are often covered by photoautotrophic communities that play a significant role in the biological fixation of C and N at the global scale. Bryophytes (mosses, liverworts and hornworts) are key members in these communities and are especially adapted to thrive in hostile environments, by growing slowly and surviving repeated dehydration events. Consequently, bryophyte communities can be extremely long-lived (>1500yrs) and can serve as valuable records of historic climate change. In particular the carbon and oxygen isotope compositions of mosses can be used as powerful proxies describing how growing season changes in atmospheric CO2 and rainfall have changed in the distant past over the land surface. Interpreting the climate signals of bryophyte biomass requires a robust understanding of how changes in photosynthetic activity and moisture status regulate the growth and isotopic composition of bryophyte biomass. Thus theoretical models predicting how changes in isotopic enrichment and CO2 discrimination respond to dehydration and rehydration are used to tease apart climatic and isotopic source signals. Testing these models with high resolution datasets obtained from new generation laser spectrometers can provide more information on how these plants that lack stomata cope with water loss. In addition novel tracers such as carbonyl sulfide (COS) can also be measured at high resolution and precision (<5ppt) and used to constrain understanding of diffusional and enzymatic limitations during dehydration and rehydration events in the light and the dark. Here, we will present for the first time simultaneous high-resolution chamber measurements of COS, 13CO2, CO18O and H218O fluxes by a bryophyte species (Marchantia sp.) in the light and during the dark, through complete desiccation cycles. Our measurements consistently reveal a strong enrichment dynamic in the oxygen isotope composition of transpired water over the dessication cycle that caused an increase

  1. Refsiréttur : um 2. mgr. 218. gr. almennra hegningarlaga nr. 19/1940 : þegar ekki hlýst bani af atlögu

    OpenAIRE

    Aldís Ýr Ólafsdóttir 1983

    2009-01-01

    Með lögum um breytingar á almennum hegningarlögum nr. 20/1981 var annarri málsgrein bætt við 218. gr. almennra hegningarlaga nr. 19/1940. Var þetta gert þar sem of ólík brot voru heimfærð undir ákvæðið sem tók til allt frá minniháttar líkamsmeiðingum, t.d. beinbrot, og allt til stórfelldra líkamsmeiðinga þar með talið þegar bani hlaust af líkamsárás. Ritgerð þessi fjallar um líkamsárásir sem valda stórfelldu líkams- eða heilsutjóni sbr. 2. mgr. 218. gr. þegar ekki hlýst bani af. Farið verður ...

  2. Manndráp og meiriháttar líkamsmeiðingar - Mörk 211. gr. og 2. mgr. 218. gr. hgl. þegar bani hlýst af atlögu

    OpenAIRE

    Sonja Hjördís Berndsen 1986

    2011-01-01

    Efni ritgerðar þessarar eru skilin milli ákvæðis 211. gr. um manndráp af ásetningi og ákvæðis 2. mgr. 218. gr. almennra hegningarlaga nr. 19/1940 um meiriháttar líkamsárás, þegar bani hlýst af atlögu. Verknaður sem leiðir til dauða er felldur undir 211. gr. hgl. nái ásetningur geranda bæði til frumverknaðar og þess dauðdaga sem fylgir verknaðinum. Verði afleiðingarnar sem í dauðdaganum felast eingöngu raktar til gáleysis geranda, er háttsemi felld undir 2. mgr. 218. gr. hgl. Við athugun á...

  3. 电穿孔与脂质体 lipofectamine 转染 miR -218进入肝癌细胞效率的比较%Comparison study of the transfection efficiency between electroporation and lipofectamin-etransfection on human hepatocarcinoma cells

    Institute of Scientific and Technical Information of China (English)

    蔡磊; 李艳; 郭曼; 连肖; 杨学文; 王文斌

    2015-01-01

    目的:比较采用电穿孔和脂质体 lipofectamine 两种方法转染人肝癌细胞的效率优劣。方法:分别采用电穿孔和脂质体转染 miR -218进入人肝癌细胞 HepG2,采用 RT -PCR、Western blot、流式细胞仪、Tunel 检测等方法比较两种方法的转染后对人肝癌细胞的影响。结果:采用两种方法都可以成功将 miR -218转染进人肝癌细胞 HepG2中,降低了 HepG2中 miR -218靶基因 RNA 编辑酶 ADAR1的表达,使得细胞凋亡增加,但电穿孔转染组效率更高。结论:电穿孔转染是一种安全、高效的转染方法,值得推广。%Objective:To compare the transfection efficiencies of miR -218 into human hepatocarcinoma cells HepG2 by electroporation or lipofectamine.Methods:miR -218 was transfected either by electroporation or by lipo-fectamine.Cells were collected,and then the condition of HepG2 cells were detected by RT -PCR,Western blot,Flow Cytometry and Tunel test.Results:Both two methods could transfect miR -218 into HepG2 swimmingly,leading to the increase of apoptosis,with the apporach of electroporation had abetter effect.Conclusion:Electroporation transfection is a safe,effective approach,which is worthy promotion.

  4. Early interim 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography is prognostically superior to international prognostic score in advanced-stage Hodgkin's lymphoma: a report from a joint Italian-Danish study

    DEFF Research Database (Denmark)

    Loft, Annika; Gallamini, Andrea; Hutchings, Martin;

    2007-01-01

    PURPOSE: Starting from November 2001, 260 newly diagnosed patients with Hodgkin's lymphoma (HL) were consecutively enrolled in parallel Italian and Danish prospective trials to evaluate the prognostic role of an early interim 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG......-PET) scan and the International Prognostic Score (IPS) in advanced HL, treated with conventional ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) therapy. PATIENTS AND METHODS: Most patients (n = 190) presented with advanced disease (stages IIB through IVB), whereas 70 presented in stage IIA...... with adverse prognostic factors. All but 11 patients were treated with standard ABVD therapy followed by consolidation radiotherapy in case of bulky presentation or residual tumor mass. Conventional radiologic staging was performed at baseline. FDG-PET scan was performed at baseline and after two courses...

  5. Development & automation of a novel [(18)F]F prosthetic group, 2-[(18)F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide.

    Science.gov (United States)

    Morris, Olivia; Gregory, J; Kadirvel, M; Henderson, Fiona; Blykers, A; McMahon, Adam; Taylor, Mark; Allsop, David; Allan, Stuart; Grigg, J; Boutin, Herve; Prenant, Christian

    2016-10-01

    2-[(18)F]-Fluoro-3-pyridinecarboxaldehyde ([(18)F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [(18)F]RI-OR2-TAT has been measured in Wistar rats.

  6. Request for interim approval to operate Trench 94 of the 218-E-12B Burial Ground as a chemical waste landfill for disposal of polychlorinated biphenyl waste in submarine reactor compartments. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Cummins, G.D.

    1994-06-01

    This request is submitted to seek interim approval to operate a Toxic Substances Control Act (TSCA) of 1976 chemical waste landfill for the disposal of polychlorinated biphenyl (PCB) waste. Operation of a chemical waste landfill for disposal of PCB waste is subject to the TSCA regulations of 40 CFR 761. Interim approval is requested for a period not to exceed 5 years from the date of approval. This request covers only the disposal of small 10 quantities of solid PCB waste contained in decommissioned, defueled submarine reactor compartments (SRC). In addition, the request applies only to disposal 12 of this waste in Trench 94 of the 218-E-12B Burial Ground (Trench 94) in the 13 200 East Area of the US Department of Energy`s (DOE) Hanford Facility. Disposal of this waste will be conducted in accordance with the Compliance 15 Agreement (Appendix H) between the DOE Richland Operations Office (DOE-RL) and 16 the US Environmental Protection Agency (EPA), Region 10. During the 5-year interim approval period, the DOE-RL will submit an application seeking final 18 approval for operation of Trench 94 as a chemical waste landfill, including 19 any necessary waivers, and also will seek a final dangerous waste permit from 20 the Washington State Department of Ecology (Ecology) for disposal of lead 21 shielding contained in the SRCS.

  7. Characteristics of permittivity and permeability spectra in range of 2-18 GHz microwave frequency for Lal-xSrxMn1-yByO3 (B=Fe, Co, Ni)

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Doped LaMnO3 has unusual electromagnetic properties, which makes it possible for this material to be used for absorbing microwave. LaMnO3 systems doped by Sr at site A and Fe or Co, Ni at site B were prepared by sol-gel as an microwave absorption material and their permittivity and permeability spectra were measured by microwave vector network analyzer in the frequency range of 2-18 GHz. A novel phenomenon is discovered that the complex permittivity, complex permeability and electromagnetic loss tangent have suddenly a step change at a certain frequency and the step-change frequency is relevant to content of Sr and Fe or Co,Ni. The samples show mainly dielectric loss when microwave frequency is smaller than the step-change frequency, and mainly magnetic loss when larger than that frequency. It is indicated that anti-ferromagnetic clusters in the material can absorb energy quantum of microwave electromagnetic field to change into ferromagnetic clusters because they can overcome higher energy barrier when the frequency of incident microwave reaches a certain value.

  8. The effect of continuous work on discretionary energy expenditure in male adult construction workers in northern Mexico as studies by the 2H218O method and indirect calorimetry

    International Nuclear Information System (INIS)

    Energy balance, in relation to energy needs in populations of developing countries is an important issue in terms of nutritional status, health and food policy implications. The objective of this study was to measure the variations in discretionary energy expenditure (DEE) in male adult construction workers of different body mass index (BMI), when challenged to heavy work. Twelve adult volunteers engaged in construction work, 18-30 years, BMI range 16.7 to 28.9 were selected from different low income urban sectors in northern Mexico. These individuals were subjected to a specific work load equivalent to a physical activity index (PAI) ≥ 2.1 x BMR, within a time frame of 6 hours a day, eight out of ten days. The rest of the time including one full weekend was to their discretion. Energy expenditure was measured using the 2H218O technique. BMR and the thermic effect of food were evaluated by ventilated hood indirect calorimetry. The energy cost of fixed activities was measured by the Oxylog. A daily activity diary was kept throughout the ten days of the protocol. This study shows no evidence that individuals of different energy status in a range of BMI from 16.7 to 28.9 modify the discretionary component of their total daily expenditure to cope with the equivalent of a heavy work load (PAI ≥ 2.1) 11 refs, 1 fig., 3 tabs

  9. The microwave absorption properties of La{sub 0.8}Sr{sub 0.2}Mn{sub 1-y}Fe{sub y}O{sub 3} nanocrystalline powders in the frequency range 2-18 GHz

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, K.-S. [School of Physics Science and Technology, Central South University, Changsha Hunan 410083 (China); Xia, H. [School of Physics Science and Technology, Central South University, Changsha Hunan 410083 (China)], E-mail: xhui73@mail.csu.edu.cn; Huang, K.-L. [School of Chemistry and Chemical Engineering, Central South University, Changsha Hunan 410083 (China); Deng, L.-W. [School of Physics Science and Technology, Central South University, Changsha Hunan 410083 (China); Wang, D. [School of Physics Science and Technology, Central South University, Changsha Hunan 410083 (China); School of Physics Science and Technology, South China University of Technology, Guangzhou 510641 (China); Zhou, Y.-P.; Gao, S.-H. [School of Physics Science and Technology, Central South University, Changsha Hunan 410083 (China)

    2009-02-28

    La{sub 1-x}Sr{sub x}Mn{sub 1-y}Fe{sub y}O{sub 3} nanocrystalline powders were prepared by the sol-gel method as a microwave absorption material. The reflectance, the dielectric loss tan {delta}{sub e} and the magnetic loss tan {delta}{sub m} of the samples were calculated according to the data of electromagnetism parameters measured by a microwave vector network analyzer in the frequency range 2-18 GHz. The dielectric loss tan {delta}{sub e} and the magnetic loss tan {delta}{sub m} had a step-change at a certain frequency so that the superiority of dielectric loss change into the superiority of magnetic loss, which indicated that anti-ferromagnetic clusters in the material change into ferromagnetic clusters by absorbing quantum of microwave electromagnetic field when the frequency of incident microwave reaches a certain value. The effective absorption bandwidth higher than 10 dB reached 6.2 GHz. As a result, the La{sub 0.8}Sr{sub 0.2}Mn{sub 1-y}Fe{sub y}O{sub 3} has shown useful applications as a microwave absorption material.

  10. Automated production at the curie level of no-carrier-added 6-[(18)F]fluoro-L-dopa and 2-[(18)F]fluoro-L-tyrosine on a FASTlab synthesizer.

    Science.gov (United States)

    Lemaire, C; Libert, L; Franci, X; Genon, J-L; Kuci, S; Giacomelli, F; Luxen, A

    2015-06-15

    An efficient, fully automated, enantioselective multi-step synthesis of no-carrier-added (nca) 6-[(18)F]fluoro-L-dopa ([(18)F]FDOPA) and 2-[(18)F]fluoro-L-tyrosine ([(18)F]FTYR) on a GE FASTlab synthesizer in conjunction with an additional high- performance liquid chromatography (HPLC) purification has been developed. A PTC (phase-transfer catalyst) strategy was used to synthesize these two important radiopharmaceuticals. According to recent chemistry improvements, automation of the whole process was implemented in a commercially available GE FASTlab module, with slight hardware modification using single use cassettes and stand-alone HPLC. [(18)F]FDOPA and [(18)F]FTYR were produced in 36.3 ± 3.0% (n = 8) and 50.5 ± 2.7% (n = 10) FASTlab radiochemical yield (decay corrected). The automated radiosynthesis on the FASTlab module requires about 52 min. Total synthesis time including HPLC purification and formulation was about 62 min. Enantiomeric excesses for these two aromatic amino acids were always >95%, and the specific activity of was >740 GBq/µmol. This automated synthesis provides high amount of [(18)F]FDOPA and [(18)F]FTYR (>37 GBq end of synthesis (EOS)). The process, fully adaptable for reliable production across multiple PET sites, could be readily implemented into a clinical good manufacturing process (GMP) environment.

  11. Request for interim approval to operate Trench 94 of the 218-E-12B Burial Ground as a chemical waste landfill for disposal of polychlorinated biphenyl waste in submarine reactor compartments

    International Nuclear Information System (INIS)

    This request is submitted to seek interim approval to operate a Toxic Substances Control Act (TSCA) of 1976 chemical waste landfill for the disposal of polychlorinated biphenyl (PCB) waste. Operation of a chemical waste landfill for disposal of PCB waste is subject to the TSCA regulations of 40 CFR 761. Interim approval is requested for a period not to exceed 5 years from the date of approval. This request covers only the disposal of small 10 quantities of solid PCB waste contained in decommissioned, defueled submarine reactor compartments (SRC). In addition, the request applies only to disposal 12 of this waste in Trench 94 of the 218-E-12B Burial Ground (Trench 94) in the 13 200 East Area of the US Department of Energy's (DOE) Hanford Facility. Disposal of this waste will be conducted in accordance with the Compliance 15 Agreement (Appendix H) between the DOE Richland Operations Office (DOE-RL) and 16 the US Environmental Protection Agency (EPA), Region 10. During the 5-year interim approval period, the DOE-RL will submit an application seeking final 18 approval for operation of Trench 94 as a chemical waste landfill, including 19 any necessary waivers, and also will seek a final dangerous waste permit from 20 the Washington State Department of Ecology (Ecology) for disposal of lead 21 shielding contained in the SRCS

  12. Lipidomics and H218O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos

    Science.gov (United States)

    McDougall, Melissa Q.; Choi, Jaewoo; Stevens, Jan F.; Truong, Lisa; Tanguay, Robert L.; Traber, Maret G.

    2016-01-01

    We hypothesized that vitamin E (α-tocopherol) is required by the developing embryonic brain to prevent depletion of highly polyunsaturated fatty acids, especially docosahexaenoic acid (DHA, 22:6), the loss of which we predicted would underlie abnormal morphological and behavioral outcomes. Therefore, we fed adult 5D zebrafish (Danio rerio) defined diets without (E−) or with added α-tocopherol (E+, 500 mg RRR-α-tocopheryl acetate/kg diet) for a minimum of 80 days, and then spawned them to obtain E− and E+ embryos. The E− compared with E+ embryos were 82% less responsive (p<0.01) to a light/dark stimulus at 96 h post-fertilization (hpf), demonstrating impaired locomotor behavior, even in the absence of gross morphological defects. Evaluation of phospholipid (PL) and lysophospholipid (lyso-PL) composition using untargeted lipidomics in E− compared with E+ embryos at 24, 48, 72, and 120 hpf showed that four PLs and three lyso-PLs containing docosahexaenoic acid (DHA), including lysophosphatidylcholine (LPC 22:6, required for transport of DHA into the brain, p<0.001), were at lower concentrations in E− at all time-points. Additionally, H218O labeling experiments revealed enhanced turnover of LPC 22:6 (p<0.001) and three other DHA-containing PLs in the E− compared with the E+ embryos, suggesting that increased membrane remodeling is a result of PL depletion. Together, these data indicate that α-tocopherol deficiency in the zebrafish embryo causes the specific depletion and increased turnover of DHA-containing PL and lyso-PLs, which may compromise DHA delivery to the brain and thereby contribute to the functional impairments observed in E− embryos. PMID:26774753

  13. Lipidomics and H218O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio embryos

    Directory of Open Access Journals (Sweden)

    Melissa Q. McDougall

    2016-08-01

    Full Text Available We hypothesized that vitamin E (α-tocopherol is required by the developing embryonic brain to prevent depletion of highly polyunsaturated fatty acids, especially docosahexaenoic acid (DHA, 22:6, the loss of which we predicted would underlie abnormal morphological and behavioral outcomes. Therefore, we fed adult 5D zebrafish (Danio rerio defined diets without (E− or with added α-tocopherol (E+, 500 mg RRR-α-tocopheryl acetate/kg diet for a minimum of 80 days, and then spawned them to obtain E− and E+ embryos. The E− compared with E+ embryos were 82% less responsive (p<0.01 to a light/dark stimulus at 96 h post-fertilization (hpf, demonstrating impaired locomotor behavior, even in the absence of gross morphological defects. Evaluation of phospholipid (PL and lysophospholipid (lyso-PL composition using untargeted lipidomics in E− compared with E+ embryos at 24, 48, 72, and 120 hpf showed that four PLs and three lyso-PLs containing docosahexaenoic acid (DHA, including lysophosphatidylcholine (LPC 22:6, required for transport of DHA into the brain, p<0.001, were at lower concentrations in E− at all time-points. Additionally, H218O labeling experiments revealed enhanced turnover of LPC 22:6 (p<0.001 and three other DHA-containing PLs in the E− compared with the E+ embryos, suggesting that increased membrane remodeling is a result of PL depletion. Together, these data indicate that α-tocopherol deficiency in the zebrafish embryo causes the specific depletion and increased turnover of DHA-containing PL and lyso-PLs, which may compromise DHA delivery to the brain and thereby contribute to the functional impairments observed in E− embryos.

  14. Lipidomics and H2(18)O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos.

    Science.gov (United States)

    McDougall, Melissa Q; Choi, Jaewoo; Stevens, Jan F; Truong, Lisa; Tanguay, Robert L; Traber, Maret G

    2016-08-01

    We hypothesized that vitamin E (α-tocopherol) is required by the developing embryonic brain to prevent depletion of highly polyunsaturated fatty acids, especially docosahexaenoic acid (DHA, 22:6), the loss of which we predicted would underlie abnormal morphological and behavioral outcomes. Therefore, we fed adult 5D zebrafish (Danio rerio) defined diets without (E-) or with added α-tocopherol (E+, 500mg RRR-α-tocopheryl acetate/kg diet) for a minimum of 80 days, and then spawned them to obtain E- and E+ embryos. The E- compared with E+ embryos were 82% less responsive (p<0.01) to a light/dark stimulus at 96h post-fertilization (hpf), demonstrating impaired locomotor behavior, even in the absence of gross morphological defects. Evaluation of phospholipid (PL) and lysophospholipid (lyso-PL) composition using untargeted lipidomics in E- compared with E+ embryos at 24, 48, 72, and 120hpf showed that four PLs and three lyso-PLs containing docosahexaenoic acid (DHA), including lysophosphatidylcholine (LPC 22:6, required for transport of DHA into the brain, p<0.001), were at lower concentrations in E- at all time-points. Additionally, H2(18)O labeling experiments revealed enhanced turnover of LPC 22:6 (p<0.001) and three other DHA-containing PLs in the E- compared with the E+ embryos, suggesting that increased membrane remodeling is a result of PL depletion. Together, these data indicate that α-tocopherol deficiency in the zebrafish embryo causes the specific depletion and increased turnover of DHA-containing PL and lyso-PLs, which may compromise DHA delivery to the brain and thereby contribute to the functional impairments observed in E- embryos. PMID:26774753

  15. Prognostic Significance of 2-Deoxy-2-[18F]-Fluoro-D-Glucose PET/CT in Patients With Locally Advanced Esophageal Cancer Undergoing Neoadjuvant Chemoradiotherapy Before Surgery: A Nonparametric Approach.

    Science.gov (United States)

    Giorgetti, Assuero; Pallabazzer, Giovanni; Ripoli, Andrea; Solito, Biagio; Genovesi, Dario; Lencioni, Monica; Fabrini, Maria Grazia; D'Imporzano, Simone; Pieraccini, Laura; Marzullo, Paolo; Santi, Stefano

    2016-03-01

    To investigate the prognostic value of tumor metabolism measurements on serial 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography and computed tomography scans in patients with locally advanced esophageal cancer undergoing neoadjuvant chemoradiotherapy. Forty-five patients (63 ± 7 years, 6 female) treated with concomitant chemoradiotherapy before surgery were followed up for 24 ± 18 months (range 4-71). Positron emission tomography and computed tomography scans were obtained within 1 week before the start (PET1) and 1 month after the completion of the treatment (PET2). Total body tumor metabolic activity was measured as the sum of the parameters: SUVmax, SUV corrected for lean body mass, and total lesion glycolysis (TLG40/50/70%). Then, delta values for the parameters between PET1 and PET2 were calculated and expressed as percentage of PET1 results. At the time of the analysis, 27 patients were dead and 18 were alive. There was no difference between the 2 groups in terms of age, sex, site of the disease, histology, and the presence/absence of linfonodal metastases (P = NS). Survival random forest analysis (20,000 trees) resulted in an estimate of error rate of 36%. The nonparametric approach identified ΔTLG40 as the most predictive factor of survival (relative importance 100%). Moreover, T (17%), N (5%), and M (5%) stage of the disease, cancer histology (11%), TLG70 (5%) at the end of chemioradioterapy, and ΔTLG(50-70) (17%-5%) were positively associated with patient outcome. The nonparametric analysis confirmed the prognostic importance of some clinical parameters, such as TNM stage and cancer histology. Moreover, ΔTLG resulted to be the most important factor in predicting outcome and should be considered in risk stratification of patients treated with neoadjuvant chemoradiotherapy. PMID:27043676

  16. BDML Metadata: 218 [SSBD[Archive

    Lifescience Database Archive (English)

    Full Text Available NC-SA 0.150 2a3c851a-29f8-43da-a783-3c09668238da 0.105 x 0.105 x 0.5 (micrometer), 40 (second) http://ssbd.qbic.riken.jp/data.../source/Ce_KK_P002/RNAi_T20G5.2_040909_01/ http://ssbd.qbic.riken.jp/data.../bdml/Ce_KK_P002/RNAi_T20G5.2_040909_01.bdml0.15.xml http://ssbd.qbic.riken.jp/data/pdpml/Ce_KK_P00...2.pdpml0.05.xml http://ssbd.qbic.riken.jp/search/2a3c851a-29f8-43da-a783-3c09668238da/ http://ssbd.qbic.riken.jp/omero/webclient/?show=dataset-159 ...

  17. 10 CFR 218.3 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... established pursuant to the Agreement on an International Energy Program signed at Paris, France, on November 18, 1974, including (a) the Annex entitled “Emergency Reserves”, (b) any amendment to such Agreement that includes another nation as a Party to such Agreement, and (c) any technical or clerical...

  18. 48 CFR 218.201 - Contingency operation.

    Science.gov (United States)

    2010-10-01

    ... hours of business related courses do not apply to DoD employees or members of the armed forces who are..., DEPARTMENT OF DEFENSE CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Emergency...

  19. 50 CFR 218.13 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ... extensive training to qualify as a watchstander in accordance with the Lookout Training Handbook (NAVEDTRA... the most effective means to ensure quick and effective communication within the command structure to... Training Handbook (NAVEDTRA 12968-D). (E) After sunset and prior to sunrise, lookouts shall employ...

  20. 50 CFR 218.183 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ...) Marine observers shall be trained in the most effective means to ensure quick and effective communication... employing a scanning methodology in accordance with the Lookout Training Handbook (NAVEDTRA 12968-D). (v... Training Handbook. (vii) At night, marine observers shall scan the horizon in a series of movements...

  1. 50 CFR 218.23 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ... watchstander in accordance with the Lookout Training Handbook (NAVEDTRA 12968-D). (C) Lookout training shall... ensure quick and effective communication within the command structure to facilitate implementation of... search procedures employing a scanning method in accordance with the Lookout Training Handbook...

  2. 50 CFR 218.4 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ... extensive training to qualify as a watchstander in accordance with the Lookout Training Handbook (NAVEDTRA... the most effective means to ensure quick and effective communication within the command structure to... Training Handbook (NAVEDTRA 12968-D). (E) After sunset and prior to sunrise, lookouts shall employ...

  3. 29 CFR 1910.218 - Forging machines.

    Science.gov (United States)

    2010-07-01

    ... inspection of guards and point of operation protection devices at frequent and regular intervals. Recording... wedges shall be made of material the strength and construction of which should meet or exceed the... a man to reach the full length of the die without placing his hand or arm between the dies....

  4. 32 CFR 218.1 - Policies.

    Science.gov (United States)

    2010-07-01

    .... In determining the veteran's dose, initial neutron, initial gamma, residual gamma, and internal (inhaled and ingested) alpha, beta, and gamma shall be considered. However, doses will be reported as gamma... aircraft crew. Either one person was badged in a group performing the same function, or only...

  5. 32 CFR 218.2 - General procedures.

    Science.gov (United States)

    2010-07-01

    ... determining the external gamma dose. (b) Identify group activities and locations for period(s) of possible... intended group. (f) Calculate the mean external gamma dose, with variance and confidence limits, for each... relate activities shielding, position, and other factors to radiation environment as a function of...

  6. Comparative Oncology: Evaluation of 2-Deoxy-2-[18F]fluoro-D-glucose (FDG Positron Emission Tomography/Computed Tomography (PET/CT for the Staging of Dogs with Malignant Tumors.

    Directory of Open Access Journals (Sweden)

    Stefanie M F Seiler

    Full Text Available 2-Deoxy-2-[18F]fluoro-D-glucose PET/CT is a well-established imaging method for staging, restaging and therapy-control in human medicine. In veterinary medicine, this imaging method could prove to be an attractive and innovative alternative to conventional imaging in order to improve staging and restaging. The aim of this study was both to evaluate the effectiveness of this image-guided method in canine patients with spontaneously occurring cancer as well as to illustrate the dog as a well-suited animal model for comparative oncology.Ten dogs with various malignant tumors were included in the study and underwent a whole body FDG PET/CT. One patient has a second PET-CT 5 months after the first study. Patients were diagnosed with histiocytic sarcoma (n = 1, malignant lymphoma (n = 2, mammary carcinoma (n = 4, sertoli cell tumor (n = 1, gastrointestinal stromal tumor (GIST (n = 1 and lung tumor (n = 1. PET/CT data were analyzed with the help of a 5-point scale in consideration of the patients' medical histories.In seven of the ten dogs, the treatment protocol and prognosis were significantly changed due to the results of FDG PET/CT. In the patients with lymphoma (n = 2 tumor extent could be defined on PET/CT because of increased FDG uptake in multiple lymph nodes. This led to the recommendation for a therapeutic polychemotherapy as a treatment. In one of the dogs with mammary carcinoma (n = 4 and in the patient with the lung tumor (n = 1, surgery was cancelled due to the discovery of multiple metastasis. Consequently no treatment was recommended.FDG PET/CT offers additional information in canine patients with malignant disease with a potential improvement of staging and restaging. The encouraging data of this clinical study highlights the possibility to further improve innovative diagnostic and staging methods with regard to comparative oncology. In the future, performing PET/CT not only for staging but also in therapy control could offer a

  7. Evaluation of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography in gastric carcinoma. Relation to histological subtypes, depth of tumor invasion, and glucose transporter-1 expression

    International Nuclear Information System (INIS)

    Variable uptake of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) has been noticed in positron emission tomography (PET) studies of gastric carcinoma patients, with low uptake occurring especially in some particular histological subtypes and early carcinomas. But this phenomenon has not been adequately explained. The aim of the present study is to clarify FDG uptake in gastric carcinomas especially focusing on histological subtypes, the depth of tumor invasion, and glucose transporter-1 (GLUT-1) expression which is considered to be one of the major factors for higher FDG uptake in human malignant tumors. FDG-PET was performed on 35 preoperative patients with gastric carcinoma. Forty macroscopically distinguishable lesions on a surgical specimen were histologically classified into two subtypes: Cohesive type (papillary adenocarcinoma, tubular adenocarcinoma, and solid type poorly differentiated adenocarcinoma) or Non-cohesive type (signet-ring cell carcinoma and non-solid type poorly differentiated carcinoma). GLUT-1 expression was immunohistochemically determined. Histological parameters (GLUT-1 expression, histological subtypes, the depth of invasion, lymphatic permeation, venous invasion and tumor size) were evaluated, and factors for FDG uptake (detectability and the degree) and GLUT-1 overexpression were determined by multiple regression analysis. Nineteen of 40 gastric carcinomas showed detectable FDG uptake (48%), multiple regression analysis revealed that both the depth of invasion and histological subtypes are independent factors that influence the detectable FDG uptake in gastric carcinoma (R2=0.66). GLUT-1 expression was seen from an early cancer stage and the cohesive type was an independent factor influencing the overexpression of GLUT-1 (R2=0.66). GLUT-1 expression was the most influential factor for the degree of FDG uptake in gastric carcinoma (R2=0.68). This study provided important information on the clinical application of FDG-PET in gastric carcinoma that

  8. Molecular clouds and star formation toward the Galactic plane within 216.25° ≤ l ≤ 218.75° and -0.75° ≤ b ≤ 1.25°

    Science.gov (United States)

    Gong, Y.; Mao, R. Q.; Fang, M.; Zhang, S. B.; Su, Y.; Yang, J.; Jiang, Z. B.; Xu, Y.; Wang, M.; Wang, Y.; Lu, D. R.; Sun, J. X.

    2016-04-01

    Context. Molecular clouds trace the spiral arms of the Milky Way and all its star forming regions. Large-scale mapping of molecular clouds will provide an approach to understand the processes that govern star formation and molecular cloud evolution. Aims: As a part of the Milky Way Imaging Scroll Painting (MWISP) survey, the aim is to study the physical properties of molecular clouds and their associated star formation toward the Galactic plane within 216.25° ≤ l ≤ 218.75° and -0.75° ≤ b ≤ 1.25°, which covers the molecular cloud complex S287. Methods: Using the 3 × 3 Superconducting Spectroscopic Array Receiver (SSAR) at the PMO-13.7m telescope, we performed a simultaneous 12CO (1-0), 13CO (1-0), C18O (1-0) mapping toward molecular clouds in a region encompassing 3.75 square degrees. We also make use of archival data to study star formation within the molecular clouds. Results: We reveal three molecular clouds, the 15 km s-1 cloud, the 27 km s-1 cloud, and the 50 km s-1 cloud, in the surveyed region. The 50 km s-1 cloud is resolved with an angular resolution of ~1' for the first time. Investigating their morphology and velocity structures, we find that the 27 km s-1 cloud is likely affected by feedback from the stellar association Mon OB3 and the 50 km s-1 cloud is characterized by three large expanding molecular shells. The surveyed region is mapped in C18O (1-0) for the first time. We discover seven C18O clumps that are likely to form massive stars, and 15 dust clumps based on the Bolocam Galactic Plane Survey (BGPS) archive data. Using infrared color-color diagrams, we find 56 Class I and 107 Class II young stellar object (YSO) candidates toward a slightly larger region of 5.0 square degrees. Based on the distribution of YSO candidates, an overdensity is found around the HII region S287 and the intersection of two shells; this is probably indicative of triggering. The star formation efficiency (SFE) and rate (SFR) of the 27 km s-1 cloud are

  9. Triple water vapor isotopic (H218O, HD16O, H217O) measurements above the Greenland Ice Sheet and importance for understanding the atmospheric hydrological cycle in the Arctic

    Science.gov (United States)

    Steen-Larsen, H.; Winkler, R.; Prie, F.; Landais, A.; Masson-Delmotte, V.; Risi, C.; Berkelhammer, M. B.; Noone, D. C.; O'Neill, M.; Guillevic, M.; Hirabayashi, M.; Schneider, D. P.; Stenni, B.

    2012-12-01

    Novel triple water stable isotope measurements (H_2^{18}O, HD^{16}O, H_2^{17}O) revealing both d-excess and ^{17}O-excess have been carried out on both vapor and snow samples with the aim at improving our understanding of the atmospheric processes affecting ice core isotopic records. This has shed new light on both the super saturation during snow crystal formation and source region conditions [e.g. Landais et al. 2012; 2008, Winkler et al. 2012, Uemura et al. 2010]. We have for the last four summer seasons since 2009 measured the isotopic composition of the water vapor in continuous mode on top of the Greenland Ice Sheet as part of the NEEM deep ice core-drilling project (77.45 N 51.06 W, 2484 m a.s.l). Furthermore, during the 2012 summer campaign we carried out continuous isotopic water vapor measurements in tandem at two sites on top of the Greenland Ice sheet: at both Summit station (72.50 N 38.50 W, 3250 m a.s.l) and NEEM station. By comparing the observed variability of the in-situ water vapor isotopic composition with isotope-enabled general circulation models we have been able to both validate and point to weaknesses in the modeled isotopic values. We find that the general circulation model (LMDZiso) used here reasonably captures both variations in absolute humidity and vapor isotope composition. However comparing the observed and modeled d-excess reveals a very poor correlation. We understand this as indications for the general circulation model (LMDZiso) having a correct representation of the large-scale atmospheric circulation but having poor sub-grid physics performance especially related to the simulation of relative humidity in the Arctic Ocean boundary layer. We use back trajectory analysis to relate the origin of the water vapor to its isotopic fingerprint, in particular for the d-excess and ^{17}O-excess. This leads us to identify Arctic and North Atlantic origin respectively. By combining the d-excess and ^{17}O-excess we are able to show the

  10. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  11. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  12. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  13. Dicty_cDB: CFJ218 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available _04H08_TEXF1 Psoroptes ovis mixed Psoroptes ovis cDNA clone Po_ad_04H08 5' similar to O46030 CYSTEINE PROT...EINASE. Sitophilus zeamais (maize weevil), mRNA sequence. 50 2e-06 3 dna update 200

  14. 36 CFR 218.10 - Objection time periods and process.

    Science.gov (United States)

    2010-07-01

    ... holidays. However, when the time period expires on a Saturday, Sunday, or Federal holiday, the time is extended to the end of the next Federal working day as stated in the legal notice or to the end of...

  15. Dicty_cDB: VSF218 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available significant alignments: (bits) Value N BD092935 |BD092935.1 Methods and compositions for synthesis of long c...hain polyunsaturated fatty acids in plants. 936 0.0 1 BD082645 |BD082645.1 Methods and composition...s for synthesis of long chain polyunsaturated fatty acids. 936 0.0 1 BD082630 |BD082630.1 Methods and composition

  16. 50 CFR 218.184 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... of any marine mammal sighting so that appropriate action may be taken by the chain of command. For... NMFS through the Navy's chain-of-command. (f) Annual NSWC PCD Report—The Navy shall submit a...

  17. 7 CFR 65.218 - Pre-labeled.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COUNTRY OF ORIGIN LABELING... commodity that has the commodity's country of origin and the name and place of business of the manufacturer... consumer, or on the master shipping container. The place of business information must include at a...

  18. 50 CFR 218.102 - Permissible methods of taking.

    Science.gov (United States)

    2010-10-01

    ... (Megaptera novaeangliae)—4,025 (an average of 805 annually); (B) Fin whale (Balaenoptera physalus)—910 (an average of 182 annually); (C) Blue whale (Balaenoptera musculus)—650 (an average of 130 annually); (D) Sei whale (Balaenoptera borealis)—1,625 (an average of 325 annually); (E) Minke whale...

  19. 30 CFR 218.51 - How to make payments.

    Science.gov (United States)

    2010-07-01

    ... equal annual installments over a specified number of years. EFT—Electronic Funds Transfer. Any paperless... of Indian Affairs (BIA) agency or area office represented by the leases on your report or invoice document. You must include the name of the applicable BIA agency or area office on your payment. Make...

  20. 30 CFR 218.152 - Fishermen's Contingency Fund.

    Science.gov (United States)

    2010-07-01

    ... MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES Oil, Gas and Sulfur..., any holder of a lease issued or maintained under the Outer Continental Shelf Lands Act and any...

  1. 32 CFR 218.3 - Dose reconstruction methodology.

    Science.gov (United States)

    2010-07-01

    ... sensitivity to variations in the parameters used. The results of the gamma data calculations are then compared... describes and defines the radiological conditions as a function of time for all locations of concern, that... radiation environment results from several types of gamma and neutron emissions. Prompt neutron and...

  2. 30 CFR 218.201 - Method of payment.

    Science.gov (United States)

    2010-07-01

    ..., rather than the Form MMS-2014. (b) For Form MMS-4430 payments, include both your customer identification and your customer document identification numbers on your payment document, rather than the..., include the MMS Courtesy Notice when provided or write your customer identification number and...

  3. 50 CFR 218.181 - Permissible methods of taking.

    Science.gov (United States)

    2010-10-01

    ... (Stenella frontalis)—2,355 (an average of 471 annually); (v) Pantropical spotted dolphin (S. attenuata)—115...) Atlantic spotted dolphin (Stenella frontalis)—10 (an average of 2 annually); (iii) Pantropical spotted dolphin (S. attenuata)—5 (an average of 1 annually); (ix) Spinner dolphin (S. longirostris)—5 (an...

  4. 49 CFR 218.99 - Shoving or pushing movements.

    Science.gov (United States)

    2010-10-01

    ..., humping, or dropping cars. (b) General movement requirements—(1) Job briefing. Rolling equipment shall not... employee who will direct the move. The job briefing shall include the means of communication to be used... shall be demonstrated (i) To be failsafe; or (ii) To provide suitable redundancy to prevent...

  5. 7 CFR 2.18 - Under Secretary for Food Safety.

    Science.gov (United States)

    2010-01-01

    ... (21 U.S.C. 120). (iv) Enter into contracts, grants, or cooperative agreements to further research... animals intended and offered for export (21 U.S.C. 601-613, 615-624, 641-645, 661, 671-680, 683, 691-692... to the Secretary by Executive Order 12580, 3 CFR, 1987 Comp., p. 193, under the following...

  6. 50 CFR 218.24 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ...) Whether calves were observed; (E) Initial detection sensor; (F) Length of time observers maintained visual... systematic line-transect surveys (particularly for species such as beaked whales that are rarely seen). (iii... Monitoring Workshop participants will be asked to review the Navy's Monitoring Plans and monitoring...

  7. 50 CFR 218.5 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ...) Initial detection sensor; (F) Length of time observers maintained visual contact with marine mammal; (G... hydrophone array shall be used to supplement the ship-based systematic line-transect surveys (particularly... convene a Monitoring Workshop in which the Monitoring Workshop participants will be asked to review...

  8. 50 CFR 218.14 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ...) Initial detection sensor; (F) Length of time observers maintained visual contact with marine mammal; (G... hydrophone array shall be used to supplement the ship-based systematic line-transect surveys (particularly... participants will be asked to review the Navy's Monitoring Plans and monitoring results and make...

  9. 50 CFR 218.105 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... trying to categorize in any way, the observed behavior of the animals (such as animal closing to bow ride... without trying to categorize in any way, the observed behavior of the animals (such as animal closing to... animal(s), the condition of the animal(s) (including carcass condition if the animal is dead),...

  10. Dicty_cDB: AFO218 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available lii cDNA clone PYCNG69 5' end, mRNA sequence. 70 1e-21 3 BD183626 |BD183626.1 Material for diagnosing malari...D183625.1 Material for diagnosing malaria and immune antigen for suppressing growth of plasmodium. 58 4e-19 ...a and immune antigen for suppressing growth of plasmodium. 58 4e-19 6 BD183625 |B

  11. Testing program PIN using experimental results from Report CENPD--218

    International Nuclear Information System (INIS)

    The applicability is tested of program PIN (derived from program GAPCON-THERMAL-2) in the thermomechanical modelling of light water reactor fuel elements. Four variants of fuel elements designated A through to D were calculated using the PIN. Variant B consists of two fuel elements with a different irradiation history. The elements were irradiated in different reactors. The experimental data (temperature in the middle of the fuel, the amount of fission products, axial and radial can deformations, fuel-can gap) are shown in tables and graphs. (H.S.)

  12. Body mass index cut-offs for overweight and obesity in Chinese children and adolescents aged 2-18 years%中国2~18岁儿童青少年超重和肥胖筛查体重指数界值点的研究

    Institute of Scientific and Technical Information of China (English)

    李辉; 宗心南; 季成叶; 米杰

    2010-01-01

    Objective To study the body cut-offs of mass index (BMI) for the purpose of screening overweight and obesity for Chinese children and adolescents aged 2-18 years. Methods Based on the BMI growth reference values for Chinese children aged 0-18, using the common methods to establish the BMI cut-offs for screening overweight and obesity. These methods were having the same empirical percentile or Z scores and the BMI value at 18 years consistent with adults.Three sets of BMI cut-offs, including (BMI24, BMI28) , (P85, P95) and (Z1, Z2) , were initially identified. Differences were compared on different cut-off points and prevalence rates of overweight and obesity with different BMI reference, different values and "prevalence" of overweight and obesity based on "2004 Beijing Child and Adolescent Metabolic Syndrome Study ". Cut-offs standards which recommended by the Chinese Working Group on Obesity for Children (WGOC) and by the International Obesity Task Force (IOTF) were also used. Finally the appropriate cut-offs were defined. Results Three sets of BMI cut-offs for screening overweight and obesity for Chinese children and adolescents aged 2-18 years were obtained according to the above mentioned methods for selection. The prevalence rates of overweight and obesity defined by those cut-offs appeared not to be significantly different. Compared with the WGOC, the BMI cut-off points for screening overweight and obesity for both boys and girls from our study were very close to the WGOC', but cut-off points for screening overweight for girls aged 8.5-15.5 y was 0.3-1.0 kg/m2 lower than the WGOC'. Going through the database on screening of "2004 Beijing Children's Metabolic Syndrome Survey ", the prevalence of overweight for girls was about 3.4% higher than using the cut-offs of WGOC. Conclusion Results from this study suggested that the BMI cut-offs passed through the cut-off point of BMI24 and BMI28 at 18 years was appropriate for screening overweight and obesity in

  13. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE,CERN

    OpenAIRE

    Rothe, Sebastian

    2012-01-01

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spec...

  14. Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer

    DEFF Research Database (Denmark)

    Hoei-Hansen, Christina E; Holm, Mette; Rajpert-De Meyts, Ewa;

    2003-01-01

    of other dysgenetic features was immature tubules with undifferentiated Sertoli cells, 4.6%; microcalcifications (microliths), 6.0%; and the presence of a Sertoli-cell-only pattern in at least a few tubules, 13.8%. The cumulative incidence of one or more signs of testicular dysgenesis was 25.2%. In a few...

  15. Structure of Even-Even 218-230 Ra Isotopes within the Interacting Boson Approximation Model

    Directory of Open Access Journals (Sweden)

    Diab S. M.

    2008-01-01

    Full Text Available A good description of the excited positive and negative parity states of radium nuclei (Z=88, N=130-142 is achieved using the interacting boson approximation model (IBA-1. The potential energy surfaces, energy levels, parity shift, electromagnetic transition rates B(E1, B(E2 and electric monopole strength X(E0/E2 are calculated for each nucleus. The analysis of the eigenvalues of the model Hamiltonian reveals the presence of an interaction between the positive and negative parity bands. Due to this interaction the $Delta I = 1$ staggering effect, between the energies of the ground state band and the negative parity state band, is produced including beat patterns.

  16. 38 CFR 1.218 - Security and law enforcement at VA facilities.

    Science.gov (United States)

    2010-07-01

    ... the influence of alcoholic beverages, narcotic drugs, hallucinogens, marijuana, barbiturates, or amphetamines is prohibited. Entering property under the influence of any narcotic drug, hallucinogen, marijuana... property of any narcotic drug, hallucinogen, marijuana, barbiturate, or amphetamine (unless prescribed by...

  17. Calibration of ground-based Lidar instrument WLS7-218

    DEFF Research Database (Denmark)

    Yordanova, Ginka; Gómez Arranz, Paula

    This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbines at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement uncertain......This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbines at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement...... uncertainties provided by measurement standard and corresponding lidar wind speed indications with associated measurement uncertainties. The lidar calibration concerns the 10 minute mean wind speed measurements. The comparison of the lidar measurements of the wind direction with that from wind vanes...

  18. Yeast Interacting Proteins Database: YGL044C, YDL218W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin Rows ...egulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin

  19. Yeast Interacting Proteins Database: YGR218W, YDL065C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available PEX19 Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), bin...ith this bait as prey (0) Prey ORF YDL065C Prey gene name PEX19 Prey description Chaperone and import receptor for newly

  20. Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer

    DEFF Research Database (Denmark)

    Hoei-Hansen, Christina E; Holm, Mette; Rajpert-De Meyts, Ewa;

    2003-01-01

    This study was prompted by a hypothesis that testicular germ cell cancer may be aetiologically linked to other male reproductive abnormalities as a part of the so-called 'testicular dysgenesis syndrome' (TDS). To corroborate the hypothesis of a common association of germ cell cancer with testicular...... presenting with testicular germ cell neoplasms of the adolescent and young type. The findings therefore support the hypothesis that this cancer is part of a testicular dysgenesis syndrome. The presence of contralateral carcinoma in situ was higher in the present study than previously reported....... dysgenesis, microscopic dysgenetic features were quantified in contralateral testicular biopsies in patients with a testicular germ cell tumour. Two hundred and eighty consecutive contralateral testicular biopsies from Danish patients with testicular cancer diagnosed in 1998-2001 were evaluated...

  1. 2-18 GHz broadband MMIC SPDT switches based on GMIC and heterolithic circuits

    OpenAIRE

    Howell, Charles M.; Regan, John J.

    1990-01-01

    Monolithic integrated circuit switches can be fabricated using either GaAs FETs or with PIN diodes as the active elements. Each offers advantages and disadvantages to the circuit design. It has been shown that because of their higher switching Q1,4 that PIN diodes should exhibit lower loss and higher isolation in the same circuit than a switch made with a FET as the switching element. Conversely, FET based switches offer an advantage of less control power and better DC to RF isolation of the ...

  2. SU-E-J-218: Novel Validation Paradigm of MRI to CT Deformation of Prostate

    Energy Technology Data Exchange (ETDEWEB)

    Padgett, K [University of Miami School of Medicine - Radiation Oncology, Miami, FL (United States); University of Miami School of Medicine - Radiology, Miami, FL (United States); Pirozzi, S; Nelson, A; Piper, J; Horvat, M [MIM Software Inc., Cleveland, OH (United States); Stoyanova, R; Dogan, N; Pollack, A [University of Miami School of Medicine - Radiation Oncology, Miami, FL (United States)

    2015-06-15

    Purpose: Deformable registration algorithms are inherently difficult to characterize in the multi-modality setting due to a significant differences in the characteristics of the different modalities (CT and MRI) as well as tissue deformations. We present a unique paradigm where this is overcome by utilizing a planning-MRI acquired within an hour of the planning-CT serving as a surrogate for quantifying MRI to CT deformation by eliminating the issues of multi-modality comparisons. Methods: For nine subjects, T2 fast-spin-echo images were acquired at two different time points, the first several weeks prior to planning (diagnostic-MRI) and the second on the same day as the planning-CT (planning-MRI). Significant effort in patient positioning and bowel/bladder preparation was undertaken to minimize distortion of the prostate in all datasets. The diagnostic-MRI was rigidly and deformably aligned to the planning-CT utilizing a commercially available deformable registration algorithm synthesized from local registrations. Additionally, the quality of rigid alignment was ranked by an imaging physicist. The distances between corresponding anatomical landmarks on rigid and deformed registrations (diagnostic-MR to planning-CT) were evaluated. Results: It was discovered that in cases where the rigid registration was of acceptable quality the deformable registration didn’t improve the alignment, this was true of all metrics employed. If the analysis is separated into cases where the rigid alignment was ranked as unacceptable the deformable registration significantly improved the alignment, 4.62mm residual error in landmarks as compared to 5.72mm residual error in rigid alignments with a p-value of 0.0008. Conclusion: This paradigm provides an ideal testing ground for MR to CT deformable registration algorithms by allowing for inter-modality comparisons of multi-modality registrations. Consistent positioning, bowel and bladder preparation may Result in higher quality rigid registrations than typically achieved which limits the impact of deformable registrations. In this study cases where significant differences exist, deformable registrations provide significant value.

  3. 30 CFR 218.104 - Exemption of States from certain interest and penalties.

    Science.gov (United States)

    2010-07-01

    ... MINERALS REVENUE MANAGEMENT COLLECTION OF MONIES AND PROVISION FOR GEOTHERMAL CREDITS AND INCENTIVES Oil... Interior for failure to comply with the Emergency Petroleum Allocation Act of 1973, as amended, or any... Act of 1973, as amended. Each State's share shall be assessed against monies owed to the State....

  4. http://www.se.org.pk/File-Download.aspx?publishedid=218

    Directory of Open Access Journals (Sweden)

    Syed Saqlain Hussain, Muhammad Jamil, Muhammad Sadiq and Shahzada Munawar Mehdi

    2012-05-01

    Full Text Available It is an established fact that temporary waterlogging occurs at first irrigation to wheat crop in rice-wheat cropping system. This is also true in saline sodic soils. Wheat crop becomes pale yellow just after first irrigation resulting in severe reduction in growth and yield. This study was planned to address this problem by various management strategies like irrigation at 25 days after sowing (DAS without fertilizer, irrigation at 25 DAS + 120-110-70 NPK kg ha-1, irrigation at 25 DAS + 120-110-70 NPK kg ha-1 + 25 kg sulphuric acid per hectare, irrigation at 25 DAS+ 120-110-70 NPK kg ha-1 +12 kg sulphuric acid per hectare and irrigation at 40 DAS +120-110-70 NPK kg ha-1. A saline sodic field {pHs =8.92, ECe =5.70 (dS m-1 and SAR=23.71 (mmol L-11/2} was selected. Maximum grain yield (3.01 t ha-1, number of tillers (437 m-2, 1000-grain weight (35.43 g and number of grains spike-1 (40 were produced with the application of 120-110-70 NPK kg ha-1 + 25 kg ha -1 sulphuric acid at first irrigation applied 25 days after sowing in saline sodic soil.

  5. 50 CFR 218.10 - Specified activity and specified geographical area and effective dates.

    Science.gov (United States)

    2010-10-01

    ... training events indicated in paragraph (c)(1)(ii) of this section: (i) Underwater Explosives: (A) AGM-114 (Hellfire missile); (B) AGM-65 E/F (Maverick missile); (C) Mine Neutralization (20 lb NEW charges); (D)...

  6. 50 CFR 218.1 - Specified activity, specified geographical area and effective dates.

    Science.gov (United States)

    2010-10-01

    ... events indicated in paragraph (c)(1)(ii) of this section: (i) Underwater Explosives: (A) AGM-114 (Hellfire missile) (B) AGM-65 E/F (Maverick missile) (C) MK-83/GBU-32 (1,000 lb High Explosive bomb) (D) Airgorne Mine Neutralization system (AMNS) (E) 20 lb NEW charges (F) AGM-88 (HARM) (G) 5″ Naval Gunfire...

  7. 20 CFR 218.44 - When a remarried widow(er) annuity ends.

    Science.gov (United States)

    2010-04-01

    ...(er)— (1) Dies; (2) Becomes entitled to an old age benefit under the Social Security Act that is equal... becomes entitled to an annuity based upon age). (c) Entitlement based on “child in care.” When the... longer in care); (3) The last day of the month before the month in which the child attains age 16,...

  8. 20 CFR 218.43 - When a surviving divorced spouse annuity ends.

    Science.gov (United States)

    2010-04-01

    ... surviving divorced spouse— (1) Dies; (2) Becomes entitled to an old age benefit under the Social Security... upon age). (c) Entitlement based on “child in care.” When the surviving divorced spouse annuity is... spouse annuity ends. (a) Entitlement based on age. When the surviving divorced spouse annuity is based...

  9. Adjustable valves in normal-pressure hydrocephalus: a retrospective study of 218 patients

    DEFF Research Database (Denmark)

    Zemack, G.; Rommer, Bertil Roland

    2008-01-01

    OBJECTIVE: We sought to assess the value of adjusting shunt valve opening pressure, complications, and outcomes with the use of an adjustable shunt valve in the treatment of patients with normal-pressure hydrocephalus (NPH). METHODS: In a single-center retrospective study, 231 adjustable valves...

  10. 50 CFR 218.100 - Specified activity and specified geographical area.

    Science.gov (United States)

    2010-10-01

    ... Command Activated Sonobuoy System (DICASS) sonobuoys)-up to 8270 sonobuoys over the course of 5 years (an average of 1654 sonobuoys per year); (iv) AN/AQS-22 (helicopter dipping sonar)—up to 2,960 dips over...

  11. Olivia BENHAMOU, Avorter aujourd’hui, Paris, Mille et une nuits, 2004, 218 p.

    OpenAIRE

    KNIBIEHLER, Yvonne

    2005-01-01

    Le trentième anniversaire de la loi Veil a suscité de nombreux ouvrages dont celui-ci. L’auteure, une journaliste née en 1973, un an avant cette loi, s’est engagée dans une investigation méthodique d’excellente qualité afin d’en mesurer les effets. Elle a découvert avec stupeur que pour bien des femmes l’avortement reste encore un calvaire. Le livre, composé et écrit avec talent, exprime son émotion et sa révolte, et se lit d’un trait. Les chapitres présentent, en alternance, un témoignage d’...

  12. Calibration of ground-based lidar instrument WLS7-218

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Wagner, Rozenn

    This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbine at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement uncertaint...

  13. Geohydrology of the 218-W-5 Burial Ground, 200-West Area, Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Bjornstad, B.N.

    1990-05-01

    Construction a disposal facility for solid, mixed low-level radioactive and hazardous wastes at the Hanford Site in southeastern Washington State (Figure 1) is planned. A site-specific performance assessment for each new disposal facility to ensure that wastes will be isolated from the environment is required. To demonstrate the adequacy of the facility for isolating the wastes, computer codes are used to simulate the physical processes that could cause the waste to migrate to underground water supplies or to the land's surface. The purpose of this report is provide a compilation and interpretation of geologic and hydrologic data available use in the performance assessment modeling. A variety of data are needed to model flow and transport from a solid-waste burial trench. These data include soil water content, soil moisture potential, saturated and unsaturated hydraulic conductivity, and phase mineralogy of the soils and sediments within the vadose zone. The hydrologic data that are critical for quantifying the water storage and transport properties for unsaturated soils require a characterization of the heterogeneities of various soil layers and the moisture characteristic curves for these layers. Hydraulic properties and mineralogic data for the saturated sediments are also important for modelling the flow and transport of wastes in the unconfined aquifer. This report begins with a discussion of the procedures and methods used to gather data both in the field and in the laboratory. This is followed by a summary of the geology, including the stratigraphic framework, lithofacies, and mineralogic/geochemical characteristics of the suprabasalt sediments. The hydrology of the region of the site is discussed next. In this discussion, the characteristics of the uppermost aquifer(s), unsaturated zone, and the various hydrogeologic units are presented. 54 refs., 39 figs., 11 tabs.

  14. Heterogeneous seeding of HET-s(218–289) and the mutability of prion structures

    Energy Technology Data Exchange (ETDEWEB)

    Wan, William; Stubbs, Gerald

    2014-02-18

    One fundamental property of prions is the formation of strains—prions that have distinct biological effects, despite a common amino acid sequence. The strain phenomenon is thought to be caused by the formation of different molecular structures, each encoding for a particular biological activity. While the precise mechanism of the formation of strains is unknown, they tend to arise following environmental changes, such as passage between different species. One possible mechanism discussed here is heterogeneous seeding; the formation of a prion nucleated by a different molecular structure. While heterogeneous seeding is not the only mechanism of prion mutation, it is consistent with some observations on species adaptation and drug resistance. Heterogeneous seeding provides a useful framework to understand how prions can adapt to new environmental conditions and change biological phenotypes.

  15. AB218. The size of seminal vesicles on ultrasound is related with premature ejaculation

    Science.gov (United States)

    Yao, Bin

    2016-01-01

    Objective Myriad biological factors have been proposed to explain premature ejaculation (PE). However, data correlating PE with seminal vesicles (SV) are sparse. The study aimed to evaluate the relationship between the size of SV on ultrasound and PE and to explore the potential mechanism of the relationship. Methods A cross-sectional study was conducted that included 44 PE outpatients and another 44 male volunteers without PE. Self-estimated intravaginal ejaculatory latency time (IELT), the Premature Ejaculation Diagnostic Tool (PEDT), the International Index of Erectile Function-15 (IIEF) and the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) were used for assessment of symptoms. The size of SV and other ultrasound figures were compared between PE group and control group. Tandem mass tag (TMT) method followed by mass spectrometry analysis was used to compare the relative expression levels of seminal plasma proteins between PE group and control group. Results Compared to the control group, the PE group had significantly higher mean anterior-posterior diameter (APD) of SV. The optimal mean APD of SV cutoff level as identified by the maximal Youden index was 9.25 mm for PE. In the PE group, PEDT was also higher with mean APD of SV >9.25 mm compared with mean APD of SV <9.25 mm. PEDT was significantly correlated with mean APD of SV, even after adjusting for age, IIEF-15 erectile function score and NIH-CPSI pain domain and voiding domain score. Compared to the matched six control subjects, 102 proteins were at least 1.5-fold up- or down-regulated in seminal plasma of six PE patients. Among them, GGT1, LAMC1 and APP were significantly higher in the PE group. Conclusions Our results indicated that men with larger mean APD of SV might have a higher PEDT score. Transrectal ultrasound of SV should be considered in the clinical evaluation of patients with PE. The changes of SV might be associated with the higher expressed GGT1, LAMC1 and APP, which might further result in PE.

  16. Yeast Interacting Proteins Database: YGR218W, YMR124W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available ry, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR12...bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene Rows with this

  17. Yeast Interacting Proteins Database: YGR218W, YGR178C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available PBP1 Component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembl... glucose deprivation induced stress granules, involved in P-body-dependent granul

  18. Using Interactive Videodiscs in Open University Courses. I.E.T. Papers on Broadcasting No. 218.

    Science.gov (United States)

    Fuller, Robert G., Ed.

    This nine-paper collection from a June 1983 Open University (OU) campus workshop in Milton Keynes, England, describes an interactive video project developed for an OU undergraduate course, T252, Introduction to Engineering Materials, and discusses varied aspects of interactive videodisc program development. The following papers are included:…

  19. Detection of PRRSV in 218 field samples using six molecular methods: What we are looking for?

    DEFF Research Database (Denmark)

    Toplak, Ivan; Štukelj, Marina; Gracieux, Patrice;

    2012-01-01

    on the genetic make-up of the target viruses and confirm findings of a previous study where we showed some commercial PCR kits failed to detect specific genetic linkages of PRRSV. Thus, these finding emphatise that it is cricial that the manifactors ofl diagnostic PCR kits (conventional and real...... positive and 45 negative pig herds from Slovenia. Total viral RNA was extracted from original samples and stored in aliquots at -70 °C until analysis. RT-PCR and direct sequencing of positive samples was performed as described previously (Toplak et al., 2012). All field samples were analyzed with five...... commercial real-time RT-PCR kits (named as kit A to E) according to the instructions of producer. Results According to determined 258 nucleotides long sequences (ORF7) 102 PRRSV samples belong to Type I (identification of 12 different lineages of EU subtype 1 (a=1, b=8, c=1, d=1, e=61, f=8, g=2, h=4, i=3, j...

  20. 美国调香师对若干食用香料的评价(218

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    来源——芬美意(Firmenich);FEMA#2857,CAS#103—45—7;天然等同物;天然来源——苹果、啤酒、白肋烟草、可可、葡萄、李、草莓、茶叶、全麦面包、威士忌和红葡萄酒;香气特征——@1.0%:甜的,玫瑰花香,带有粉香的蜂蜜样香气,类似苹果、葡萄和桃子的果香韵,并带有可可和威士忌样香调;

  1. 12 CFR 218.700 - Defined terms relating to the networking exception from the definition of “broker.”

    Science.gov (United States)

    2010-01-01

    ... multiple factors or variables and: (A) Those factors or variables include multiple significant factors or...) Such measure of overall profitability or revenue is only one of multiple factors or variables used to...; or whether it results in multiple securities transactions; provided, however, that a referral fee...

  2. Absolute total cross sections for the scattering of 2--18-eV electrons by cesium atoms

    International Nuclear Information System (INIS)

    Absolute total cross sections for the scattering of electrons by cesium atoms between 2 and 18 eV have been measured using the atomic-recoil technique in the scattering-out mode. Our results are somewhat lower than those of Visconti, Slevin, and Rubin [Phys. Rev. A 3, 1310 (1971)] above 2 eV

  3. Absolute total cross sections for the scattering of 2--18-eV electrons by cesium atoms

    Energy Technology Data Exchange (ETDEWEB)

    Jaduszliwer, B.; Chan, Y.C. (Electronics Technology Center, The Aerospace Corporation, P. O. Box 92957, Los Angeles, California 90009 (United States))

    1992-01-01

    Absolute total cross sections for the scattering of electrons by cesium atoms between 2 and 18 eV have been measured using the atomic-recoil technique in the scattering-out mode. Our results are somewhat lower than those of Visconti, Slevin, and Rubin (Phys. Rev. A 3, 1310 (1971)) above 2 eV.

  4. 12 CFR 218.760 - Exemption from definition of “broker” for banks accepting orders to effect transactions in...

    Science.gov (United States)

    2010-01-01

    ... a plan under 17 CFR 270.12b-1, from the bank, the executing broker or dealer, or any other person...) Advertisement means any material that is published or used in any electronic or other public media, including any Web site, newspaper, magazine or other periodical, radio, television, telephone or tape...

  5. 12 CFR 218.701 - Exemption from the definition of “broker” for certain institutional referrals.

    Science.gov (United States)

    2010-01-01

    ... customer to the broker or dealer for investment banking services. (3) Investment banking services includes... the broker or dealer for investment banking services provided to the customer. (e) Inflation... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Exemption from the definition of âbrokerâ...

  6. CTEPP STANDARD OPERATING PROCEDURE FOR COLLECTION OF DISLODGEABLE RESIDUES -- PUF ROLLER SAMPLES FOR PERSISTENT ORGANIC POLLUTANTS (SOP-2.18)

    Science.gov (United States)

    This SOP describes the method to collect transferable residues from indoor floor surfaces. The sampling procedures described are applicable to bare floors or covered floor surfaces, e.g., carpeting and vinyl flooring. The samples will be collected only in the day care centers o...

  7. A THREE-POSITION SPECTRAL LINE SURVEY OF SAGITTARIUS B2 BETWEEN 218 AND 263 GHz. II. DATA ANALYSIS

    OpenAIRE

    Nummelin, A.; Bergman, ; P.; Hjalmarson, Å.; Friberg, P.; IRVINE, W.M; Millar, T. J.; OhiShi, M; Saito, S.

    2000-01-01

    We present an analysis of the data from our Swedish-ESO Submillimetre Telescope molecular line survey in the 1.3 mm band of the N, M, and NW positions in the Sgr B2 molecular cloud. The line emissions from 42 molecular species, and some of their isotopomers, were analyzed assuming a single temperature and a homogeneous source. In cases where a source size much smaller than the antenna beam (23″) could be estimated, optical depth effects were also accounted for. In this way rotation temperatur...

  8. The Structure of Even-Even 218-230 Ra Isotopes within the Interacting Boson Approximation Model

    Directory of Open Access Journals (Sweden)

    Diab S. M.

    2008-01-01

    Full Text Available A good description of the excited positive and negative parity states of radium nuclei ( Z = 88, N = 130–142 is achieved using the interacting boson approximation model (IBA-1. The potential energy surfaces, energy levels, parity shift, electromagnetic tran- sition rates B ( E 1 , B ( E 2 and electric monopole strength X ( E 0 / E 2 are calculated for each nucleus. The analysis of the eigenvalues of the model Hamiltonian reveals the presence of an interaction between the positive and negative parity bands. Due to this interaction the I = 1 staggering e ect, between the energies of the ground state band and the negative parity state band, is produced including beat patterns.

  9. 12 CFR 218.721 - Defined terms relating to the trust and fiduciary activities exception from the definition of...

    Science.gov (United States)

    2010-01-01

    ... management; (iv) A flat or capped per order processing fee, paid by or on behalf of a customer or beneficiary...—account-by-account test. Chiefly compensated shall mean the relationship-total compensation percentage for each trust or fiduciary account of the bank is greater than 50 percent. (2) The...

  10. 50 CFR 226.218 - Critical habitat for the U.S. DPS of smalltooth sawfish (Pristis pectinata).

    Science.gov (United States)

    2010-10-01

    ....8730 −80.8875 Everglades National Park boundary at Arsenic Bank Light. 31 24.9142 −80.9372 Everglades... boundary. 62 25.7892 −81.1969 Everglades National Park boundary. 63 25.7743 −81.1966 Everglades...

  11. Evaluation study of calves with total artificial heart (TAH) surviving for 218-293 days of pumping.

    Science.gov (United States)

    Vasků, J; Vasků, J; Dostál, M; Guba, P; Gregor, Z; Vasků, A; Urbánek, P; Necas, J; Dolezel, S; Cídl, K

    1990-12-01

    Evaluation of five longest surviving calves among a total of 54 longterm survivors, at the Brno Research Centre was performed. These calves were treated by administration of antihypertensives and partially by electrical stimulation of the right atrium to reduce central venous pressure (CVP). Treatment for CVP was effective, as compared with two groups of 5 calves each not treated in this way, and it is assumed to be an important factor for prolongation of survival. Mineralization of driving diaphragms was present in all these calves. No preventive measures of this pathologic change were performed in this group. Another complication is hemolysis, which is partly caused by immune mechanisms initiated by administration of alpha-methyl dopa and partly by mechanical destruction due to a heavily mineralized driving diaphragm. The prevention of mineralization is another important problem for future research. Other problems, concerning the survival of TAH recipients are discussed.

  12. 12 CFR 218.776 - Exemption from the definition of “broker” for banks effecting certain excepted or exempted...

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Exemption from the definition of âbrokerâ for banks effecting certain excepted or exempted transactions in a company's securities for its employee... FEDERAL RESERVE SYSTEM EXCEPTIONS FOR BANKS FROM THE DEFINITION OF BROKER IN THE SECURITIES EXCHANGE...

  13. 12 CFR 218.775 - Exemption from the definition of “broker” for banks effecting certain excepted or exempted...

    Science.gov (United States)

    2010-01-01

    ... system has the same meaning as in 17 CFR 240.15c2-11. (3) Insurance company has the same meaning as in 15... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Exemption from the definition of âbrokerâ for banks effecting certain excepted or exempted transactions in investment company securities....

  14. Compound list: simvastatin [Open TG-GATEs

    Lifescience Database Archive (English)

    Full Text Available simvastatin SST 00117 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/simv...astatin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/simv...astatin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/simv...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/simvastatin.Rat.in_vivo.Liver.Repeat.zip ...

  15. Dicty_cDB: Contig-U04658-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tagtgaacaagtaaacatattttcagaagangaagaaaccgaagtaaaa 218 ||||||||||||||||||||||||||||||||||||||||||||||||||||||...|||||| Sbjct: 159 aatatttcaaatagtgaacaagtaaacatattttcagaagangaagaaaccgaagtaaaa 21...| Sbjct: 159 aatatttcaaatagtgaacaagtaaacatattttcagaagangaagaaaccgaagtaaaa 218 Query: 219 ggtgaaaaagatatagaat...acatggttctccattgtcagatattaaaacaccaaaacctttatatttt 158 Query: 159 aatatttcaaatagtg...aacaagtaaacatattttcagaagangaagaaaccgaagtaaaa 218 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||

  16. Functional analysis of three amino acid residues of purR re-pressor, Trp147, Gln-218 and Gln-292 in Salmonella typhi-murium

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Hesheng

    2001-01-01

    [1]Zalkin, H., Nygaard, P., Escherichia coli and Salmmella typhimurium Cellular and Molecular Biology, Washington D.C: American Society for Microbiology, 1996, 561-579.[2]Maria, A. S., Choi, K. Y., Lu, F. et al., Mechanism of co-repressor mediated specific DNA binding by the purine repressor, Cell, 1995, 83: 147.[3]Choi, K. Y., Fu, L., Zalkin, H., Mutagenesis of amino acid residues required for binding of co-repressors to the purine repressor, J. Biol. Chem., 1993, 269: 24066.[4]Lu, F., Brennan, R. G., Zalkin, H., Escherichia coli purine repressor: key residues for the allsteic transition between active and inactive conformation and for inter domain signaling, Biochemistry, 1998, 37: 15680.[5]Tang Hua, Qin Junchuan, Wang Aoquan, Regulation of purine biosynthetic genes expression in Salmonella typhimurium (VI)-- Isolation and characterization of superrepressor mutants, Chinese Journal of Genetics (in Chinese), 1998, 25(2): 181.[6]Zhang Hesheng, Wang Aoquan, Regulation of purine biosynthetic genes expression in Salmonella typhimurium (X)--Isola-tion of purR(am) mutant and preliminary study of amino acid substitution, Chinese Journal of Genetics (in Chinese), 2000, 27(2): 170.[7]Davis, R. W., Roth, J. R., Advanced Bacteria Genetics, NY: Cold Spring Harbor Laboratory Press, 1984.[8]Miller, J. H., Experiments in Molecular Genetics, NY: Cold Spring Harbor Laboratory Press, 1972.[9]Sambrook, J., Fritsch, E. F., Maniatis, T., Molecular Cloning, A Laboratory Manual, NY: Cold Spring Harbor laboratory Press, 1989.[10] Katzif, S. D., Lu, C. D., Abdelal, A.T., Salmonela typhimurium purine nucleotide synthesis repressor (purR), GenBank, Ac-cession AF040636, 1998.[11] Weicket,M.J.,Adhya,S., A family of bacteria regulators homologous to Gal and Lac repressors,J.Biol.Chem.,1992,267:15869.

  17. Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-Convergence on axonal guidance

    DEFF Research Database (Denmark)

    Kaalund, Sanne S; Venø, Morten T; Bak, Mads;

    2014-01-01

    OBJECTIVE: Mesial temporal lobe epilepsy (MTLE) is one of the most common types of the intractable epilepsies and is most often associated with hippocampal sclerosis (HS), which is characterized by pronounced loss of hippocampal pyramidal neurons. microRNAs (miRNAs) have been shown to be dysregul......OBJECTIVE: Mesial temporal lobe epilepsy (MTLE) is one of the most common types of the intractable epilepsies and is most often associated with hippocampal sclerosis (HS), which is characterized by pronounced loss of hippocampal pyramidal neurons. microRNAs (miRNAs) have been shown...... to be dysregulated in epilepsy and neurodegenerative diseases, and we hypothesized that miRNAs could be involved in the pathogenesis of MTLE and HS. METHODS: miRNA expression was quantified in hippocampal specimens from human patients using miRNA microarray and quantitative real-time polymerase chain reaction RT...

  18. Hyperspectral surface materials map of quadrangle 3770, Faizabad (217) and Parkhaw (218) quadrangles, Afghanistan, showing iron-bearing minerals and other materials

    Science.gov (United States)

    King, Trude V.V.; Hoefen, Todd M.; Kokaly, Raymond F.; Livo, Keith E.; Giles, Stuart A.; Johnson, Michaela R.

    2013-01-01

    This map shows the spatial distribution of selected iron-bearing minerals and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. This map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Goethite and jarosite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  19. Hyperspectral surface materials map of quadrangle 3770, Faizabad (217) and Parkhaw (218) quadrangles, Afghanistan, showing carbonates, phyllosilicates, sulfates, altered minerals, and other materials

    Science.gov (United States)

    Kokaly, Raymond F.; King, Trude V.V.; Hoefen, Todd M.; Livo, Keith E.; Giles, Stuart A.; Johnson, Michaela R.

    2013-01-01

    This map shows the spatial distribution of selected carbonates, phyllosilicates, sulfates, altered minerals, and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. The map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Epidote or chlorite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  20. Escherichia coli K1 RS218 Interacts with Human Brain Microvascular Endothelial Cells via Type 1 Fimbria Bacteria in the Fimbriated State

    Science.gov (United States)

    Teng, Ching-Hao; Cai, Mian; Shin, Sooan; Xie, Yi; Kim, Kee-Jun; Khan, Naveed Ahmed; Di Cello, Francescopaolo; Kim, Kwang Sik

    2005-01-01

    Escherichia coli K1 is a major gram-negative organism causing neonatal meningitis. E. coli K1 binding to and invasion of human brain microvascular endothelial cells (HBMEC) are a prerequisite for E. coli penetration into the central nervous system in vivo. In the present study, we showed using DNA microarray analysis that E. coli K1 associated with HBMEC expressed significantly higher levels of the fim genes compared to nonassociated bacteria. We also showed that E. coli K1 binding to and invasion of HBMEC were significantly decreased with its fimH deletion mutant and type 1 fimbria locked-off mutant, while they were significantly increased with its type 1 fimbria locked-on mutant. E. coli K1 strains associated with HBMEC were predominantly type 1 fimbria phase-on (i.e., fimbriated) bacteria. Taken together, we showed for the first time that type 1 fimbriae play an important role in E. coli K1 binding to and invasion of HBMEC and that type 1 fimbria phase-on E. coli is the major population interacting with HBMEC. PMID:15845498

  1. Characterization of primary prostate carcinoma by anti-1-amino-2-[18F] -fluorocyclobutane-1-carboxylic acid (anti-3-[18F] FACBC) uptake

    Science.gov (United States)

    Schuster, David M; Taleghani, Pooneh A; Nieh, Peter T; Master, Viraj A; Amzat, Rianot; Savir-Baruch, Bital; Halkar, Raghuveer K; Fox, Tim; Osunkoya, Adeboye O; Moreno, Carlos S; Nye, Jonathon A; Yu, Weiping; Fei, Baowei; Wang, Zhibo; Chen, Zhengjia; Goodman, Mark M

    2013-01-01

    Anti-1-amino-3-[18F] fluorocyclobutane-1-carboxylic acid (anti-3-[18F] FACBC) is a synthetic amino acid positron emission tomography (PET) radiotracer with utility in the detection of recurrent prostate carcinoma. The aim of this study is to correlate uptake of anti-3-[18F] FACBC with histology of prostatectomy specimens in patients undergoing radical prostatectomy and to determine if uptake correlates to markers of tumor aggressiveness such as Gleason score. Ten patients with prostate carcinoma pre-radical prostatectomy underwent 45 minute dynamic PET-CT of the pelvis after IV injection of 347.8 ± 81.4 MBq anti-3-[18F] FACBC. Each prostate was co-registered to a separately acquired MR, divided into 12 sextants, and analyzed visually for abnormal focal uptake at 4, 16, 28, and 40 min post-injection by a single reader blinded to histology. SUVmax per sextant and total sextant activity (TSA) was also calculated. Histology and Gleason scores were similarly recorded by a urologic pathologist blinded to imaging. Imaging and histologic analysis were then compared. In addition, 3 representative sextants from each prostate were chosen based on highest, lowest and median SUVmax for immunohistochemical (IHC) analysis of Ki67, synaptophysin, P504s, chromogranin A, P53, androgen receptor, and prostein. 79 sextants had malignancy and 41 were benign. Highest combined sensitivity and specificity was at 28 min by visual analysis; 81.3% and 50.0% respectively. SUVmax was significantly higher (pFACBC SUVmax with Ki-67 or other IHC markers. Since there was no distinct separation between malignant and non-malignant sextants or between Gleason score levels, we believe that anti-3-[18F] FACBC PET should not be used alone for radiation therapy planning but may be useful to guide biopsy to the most aggressive lesion. PMID:23342303

  2. Characterization of primary prostate carcinoma by anti-1-amino-2-[(18)F] -fluorocyclobutane-1-carboxylic acid (anti-3-[(18)F] FACBC) uptake.

    Science.gov (United States)

    Schuster, David M; Taleghani, Pooneh A; Nieh, Peter T; Master, Viraj A; Amzat, Rianot; Savir-Baruch, Bital; Halkar, Raghuveer K; Fox, Tim; Osunkoya, Adeboye O; Moreno, Carlos S; Nye, Jonathon A; Yu, Weiping; Fei, Baowei; Wang, Zhibo; Chen, Zhengjia; Goodman, Mark M

    2013-01-01

    Anti-1-amino-3-[(18)F] fluorocyclobutane-1-carboxylic acid (anti-3-[(18)F] FACBC) is a synthetic amino acid positron emission tomography (PET) radiotracer with utility in the detection of recurrent prostate carcinoma. The aim of this study is to correlate uptake of anti-3-[(18)F] FACBC with histology of prostatectomy specimens in patients undergoing radical prostatectomy and to determine if uptake correlates to markers of tumor aggressiveness such as Gleason score. Ten patients with prostate carcinoma pre-radical prostatectomy underwent 45 minute dynamic PET-CT of the pelvis after IV injection of 347.8 ± 81.4 MBq anti-3-[(18)F] FACBC. Each prostate was co-registered to a separately acquired MR, divided into 12 sextants, and analyzed visually for abnormal focal uptake at 4, 16, 28, and 40 min post-injection by a single reader blinded to histology. SUVmax per sextant and total sextant activity (TSA) was also calculated. Histology and Gleason scores were similarly recorded by a urologic pathologist blinded to imaging. Imaging and histologic analysis were then compared. In addition, 3 representative sextants from each prostate were chosen based on highest, lowest and median SUVmax for immunohistochemical (IHC) analysis of Ki67, synaptophysin, P504s, chromogranin A, P53, androgen receptor, and prostein. 79 sextants had malignancy and 41 were benign. Highest combined sensitivity and specificity was at 28 min by visual analysis; 81.3% and 50.0% respectively. SUVmax was significantly higher (pFACBC SUVmax with Ki-67 or other IHC markers. Since there was no distinct separation between malignant and non-malignant sextants or between Gleason score levels, we believe that anti-3-[(18)F] FACBC PET should not be used alone for radiation therapy planning but may be useful to guide biopsy to the most aggressive lesion.

  3. SU-E-J-218: Evaluation of CT Images Created Using a New Metal Artifact Reduction Reconstruction Algorithm for Radiation Therapy Treatment Planning

    Energy Technology Data Exchange (ETDEWEB)

    Niemkiewicz, J; Palmiotti, A; Miner, M; Stunja, L; Bergene, J [Lehigh Valley Health Network, Allentown, PA (United States)

    2014-06-01

    Purpose: Metal in patients creates streak artifacts in CT images. When used for radiation treatment planning, these artifacts make it difficult to identify internal structures and affects radiation dose calculations, which depend on HU numbers for inhomogeneity correction. This work quantitatively evaluates a new metal artifact reduction (MAR) CT image reconstruction algorithm (GE Healthcare CT-0521-04.13-EN-US DOC1381483) when metal is present. Methods: A Gammex Model 467 Tissue Characterization phantom was used. CT images were taken of this phantom on a GE Optima580RT CT scanner with and without steel and titanium plugs using both the standard and MAR reconstruction algorithms. HU values were compared pixel by pixel to determine if the MAR algorithm altered the HUs of normal tissues when no metal is present, and to evaluate the effect of using the MAR algorithm when metal is present. Also, CT images of patients with internal metal objects using standard and MAR reconstruction algorithms were compared. Results: Comparing the standard and MAR reconstructed images of the phantom without metal, 95.0% of pixels were within ±35 HU and 98.0% of pixels were within ±85 HU. Also, the MAR reconstruction algorithm showed significant improvement in maintaining HUs of non-metallic regions in the images taken of the phantom with metal. HU Gamma analysis (2%, 2mm) of metal vs. non-metal phantom imaging using standard reconstruction resulted in an 84.8% pass rate compared to 96.6% for the MAR reconstructed images. CT images of patients with metal show significant artifact reduction when reconstructed with the MAR algorithm. Conclusion: CT imaging using the MAR reconstruction algorithm provides improved visualization of internal anatomy and more accurate HUs when metal is present compared to the standard reconstruction algorithm. MAR reconstructed CT images provide qualitative and quantitative improvements over current reconstruction algorithms, thus improving radiation treatment planning accuracy.

  4. Load unload system optimization on H218O irradiation target used for 18F- production at the cyclotron cyclone 30 from IPEN-CNEN/SP

    International Nuclear Information System (INIS)

    The demand growing in Brazil by the radiopharmaceutical [18F]FDG in positron emission tomography (PET-CT) and the 109,7 minutes half life claim special attention to the productive chain of this radiopharmaceutical. Since the [18O]water irradiation until the tomograph patient scanning, in sequential procedures that may spent about six hours, all the productive chain stages must be as reliable as possible, because any stage failed will be perceived in productive chain extremity. The position indication absence from Load and Unload 18F- Target System valve in Cyclotron Accelerators Center resulted in 18F- production loss, Irradiation Room contamination and the increase workers' dose responsible by operation and maintenance of irradiation systems. This study tested the behaviour of three types of position sensors (micro switch, reed switch and inductive sensor), into Irradiation Room 1.2 environment of the Cyclotron Accelerators Center, where there are high gamma radiation and neutrons rates because the routine 18F- and 1'23I production, through this test was possible to discover the fitter position sensor to run on 18F- Target, and after rewriting the programmable logic controller software was possible avoid this type of fail at 18F- production time in Cyclotron Accelerators Center, and to grow up the reliability on [18F]FDG productive chain. (author)

  5. Load and unload system optimization on H218 O irradiation target used for 18F- production at the cyclotron cyclone 30 from IPEN-CNEN/SP, Brazil

    International Nuclear Information System (INIS)

    The demand growing in Brazil by the radiopharmaceutical [18F] FDG in positron emission tomography (PET-CT) and the 109,7 minutes half life claim special attention to the productive chain of this radiopharmaceutical. Since the [18O]water irradiation until the tomograph patient scanning, in sequential procedures that may spent about six hours, all the productive chain stages must be as reliable as possible, because any stage failed will be perceived in productive chain extremity. The position indication absence from Load and Unload 18F- Target System valve in Cyclotron Accelerators Center resulted in 18F- production loss, Irradiation Room contamination and the increase workers dose responsible by operation and maintenance of irradiation systems. This study tested the behaviour of three types of position sensors (micro switch, reed switch and inductive sensor), into Irradiation Room 1.2 environment of the Cyclotron Accelerators Center, where there are high gamma radiation and neutrons rates because the routine 18F- and 123I production, through this test was possible to discover the fitter position sensor to run on 18F- Target, and after rewriting the programmable logic controller software was possible avoid this type of fail at 18F- production time in Cyclotron Accelerators Center, and to grow up the reliability on [18F]FDG productive chain. (author)

  6. Preliminary Thermal Modeling of HI-Storm 100S-218 Version B Storage Modules at Hope Creek Cuclear Power Station ISFSI

    Energy Technology Data Exchange (ETDEWEB)

    Cuta, Judith M.; Adkins, Harold E.

    2013-08-30

    As part of the Used Fuel Disposition Campaign of the U. S. Department of Energy, Office of Nuclear Energy (DOE-NE) Fuel Cycle Research and Development, a consortium of national laboratories and industry is performing visual inspections and temperature measurements of selected storage modules at various locations around the United States. This report documents thermal analyses in in support of the inspections at the Hope Creek Nuclear Generating Station ISFSI. This site utilizes the HI-STORM100 vertical storage system developed by Holtec International. This is a vertical storage module design, and the thermal models are being developed using COBRA-SFS (Michener, et al., 1987), a code developed by PNNL for thermal-hydraulic analyses of multi assembly spent fuel storage and transportation systems. This report describes the COBRA-SFS model in detail, and presents pre-inspection predictions of component temperatures and temperature distributions. The final report will include evaluation of inspection results, and if required, additional post-test calculations, with appropriate discussion of results.

  7. Herschel/PACS spectroscopy of NGC 4418 and Arp 220: H2O, H2^{18}O, OH, ^{18}OH, O^0, HCN and NH3

    CERN Document Server

    González-Alfonso, E; Graciá-Carpio, J; Sturm, E; Hailey-Dunsheath, S; Lutz, D; Poglitsch, A; Contursi, A; Feuchtgruber, H; Veilleux, S; Spoon, H W W; Verma, A; Christopher, N; Davies, R; Sternberg, A; Genzel, R; Tacconi, L

    2011-01-01

    Herschel/PACS spectroscopy of the (ultra)luminous infrared galaxies NGC 4418 and Arp 220 reveals high excitation in H2O, OH, HCN, and NH3. In NGC 4418, absorption lines were detected with E_lower>800 K (H2O), 600 K (OH), 1075 K (HCN), and 600 K (NH3), while in Arp 220 the excitation is somewhat lower. While clear outflow signatures are seen in Arp 220 as has been seen in previous studies, in NGC 4418 the lines tracing its outer regions are redshifted relative to the nucleus, suggesting an inflow with Mdot~100 K) nuclear continuum components, together with a more extended and colder component that is much more prominent and massive in Arp 220. A chemical dichotomy is found in both sources: on the one hand, the nuclear regions have high H2O abundances, ~0.5x10^{-5}, and high HCN/H2O and HCN/NH3 column density ratios of 0.2-0.7 and 6-9, respectively, indicating a chemistry typical of evolved hot cores where grain mantle evaporation has occurred. On the other hand, the high OH abundance, with OH/H2O ratios of ~0....

  8. 30 CFR 218.306 - May I receive a credit against production royalties for in-kind deliveries of electricity I...

    Science.gov (United States)

    2010-07-01

    ... royalties for in-kind deliveries of electricity I provide under contract to a State or county government... electricity I provide under contract to a State or county government? (a) You may receive a credit against royalties for in-kind deliveries of electricity you provide under contract to a State or county...

  9. Rendueles, Cesar. (2015. Capitalismo canalla: una historia del capitalismo a través de la literatura. Seix Barral: Barcelona. 218 pp.

    Directory of Open Access Journals (Sweden)

    Antón Sánchez Testas

    2015-12-01

    Full Text Available El dramático final de Las uvas de la ira, la novela más importante de Steinbeck, ha quedado tristemente olvidado después de que John Ford, en su adaptación al cine, decidiera cambiarlo por uno más apropiado para Hollywood. Después de todas las miserias que vive la familia Joad en su viaje a California, acaban protegidos de una crecida de agua en un endeble cobertizo. Hambrientos y agotados, la Gran Depresión se consuma para ellos en su definitiva desnudez material. Despojados de identidad cultural al ser desahuciados de sus tierras, nihilizados y explotados por el mercado laboral, no tienen otra cosa que sus cuerpos debilitados. Así, Rose of Sharon alimenta, con la leche materna destinada a un bebé que jamás llegará a nacer, al resto de proletarios, nadas sociales, en un alivio inmediato de la miseria, preludio de mayor incertidumbre. [...

  10. Chronic diseases and life events accounted for 2-18 % population attributable risks for adult hearing loss: UK Adult Psychiatric Morbidity Survey, 2007.

    Science.gov (United States)

    Shiue, Ivy

    2016-01-01

    Links between chronic diseases and hearing loss in adults have emerged. However, previous investigations were not complete, and the role of life events was unclear. Therefore, it was aimed to examine the relationships of common chronic diseases and life events and adult hearing loss in a country-wide and population-based study. Data were retrieved from UK Adult Psychiatric Morbidity Survey, 2007, being cross-sectional, including demographics, self-reported prior health conditions and hearing loss (ever and in the last 12 months), and several major life events. Analyses included Chi square test, t test, logistic regression model, and population attributable risk estimation. People who had prior health conditions including cancer, migraine, dementia, depression, cataracts, chronic bronchitis, allergy, bowel problem, bladder problem, arthritis, muscle problem or skin problem tended to report hearing loss than their counterparts. People who have experienced major life events including post-traumatic stress disorder, serious illness of close relatives, death of family, serious problems with friends, major financial crisis, valuables stolen, being bullied, violence at home, sexual abuse or running away from home were also more likely to experience ever hearing loss problem or that in the last 12 months. 2.0-13.1 % adult hearing loss could be delayed or prevented by managing chronic diseases while 4.1-18.1 % might be delayed or prevented by minimizing the negative effects of life events. Chronic diseases and life events were associated with hearing loss in adults. Better managing lifestyle to minimize detrimental impacts in future health and nursing programs would be suggested.

  11. 12 CFR 218.740 - Defined terms relating to the sweep accounts exception from the definition of “broker.”

    Science.gov (United States)

    2010-01-01

    ... securities for sales or sales promotion expenses, for personal service, or for the maintenance of shareholder... investment company's securities for sales or sales promotion expenses, for personal service, or for the....S.C. 78c(a)(4)(B)(v)), the following terms shall have the meaning provided: (a) Deferred sales...

  12. Qualidade da carne de frangos de corte submetidos a dietas suplementadas com crômio, criados em diferentes temperaturas ambientais - DOI: 10.4025/actascianimsci.v29i2.218 Meat quality of broiler chicks submeted the supplemented diets with chromium and reared in differents enviromental temperatures - DOI: 10.4025/actascianimsci.v29i2.218

    Directory of Open Access Journals (Sweden)

    Nívea Maria Brancaci Zeoula

    2007-11-01

    Full Text Available Foram realizados dois experimentos. O experimento um objetivou avaliar a composição da carne do peito de frangos alimentados com dietas suplementadas com crômio (0, 400, 800 e 1.200 μg Cr kg-1 complexado a levedura, criados sob diferentes condições de temperatura (quente, termoneutra e fria. O experimento dois objetivou avaliar a qualidade da carne do peito de frangos alimentados com dietas suplementadas com crômio (0 e 400 μg Cr kg-1, criados nas mesmas condições do experimento um e desossados em diferentes períodos (0, 5 e 24 horas. Os resultados mostram que as aves criadas em ambiente frio apresentaram a carne com menor porcentagem de matéria mineral e crômio e maior intensidade de vermelho, enquanto as aves criadas em temperatura termoneutra apresentaram carne com menor porcentagem de umidade, e as aves criadas em temperatura quente, carne com maior luminosidade. Já a suplementação de crômio não proporcionou qualquer efeito na composição e na qualidade de carne, enquanto que o aumento no período de desossa proporcionou um menor comprimento de sarcômero, força de cisalhamento e intensidade de amarelo, porém uma maior luminosidade.Two experiments were conducted being the objective of the first experiment to evaluate the the composition of breast meat of broiler chicks fed with diets supplemented with chromium yeast (0; 400; 800 and 1,200 μg Cr kg-1 reared in different environmental temperatures (hot, thermoneutral and cold. The second experiment aimed to evaluate the quality of breast meat of broiler chicks fed with diets supplemented with chromium yeast (0 and 400 μg Cr kg-1, reared in different environmental temperatures (hot, thermoneutral and cold and deboned in different periods (0, 5 and 24 hours. The results showed that birds reared in cold environmental temperature showed meat with lower mineral matter percentage and chromium and higher values of redness, whereas the birds reared in thermoneutral environment showed breast meat with lower moistness percentage and the birds reared in hot environmental temperature showed increase values of lightness. The supplementation of chromium presented no effect on the composition and meat quality. Whereas the increase in deboned period provided lower sarcomere length, shear force and yellowness, however higher lightness.

  13. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1995-12-01

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

  14. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity...

  15. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Science.gov (United States)

    2010-01-01

    .... Actinium Ac 89 Aluminum Al 13 Americium Am 95 Antimony Sb 51 Argon Ar 18 Arsenic As 33 Astatine At 85... Curium Cm 96 Dysprosium Dy 66 Einsteinium Es 99 Erbium Er 68 Europium Eu 63 Fermium Fm 100 Fluorine F...

  16. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    International Nuclear Information System (INIS)

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons

  17. Niskin Bottle Data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT218-227 during 2010 (NCEI Accession 0087596)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  18. 利用δ18O信息分析冬小麦对浅埋深地下水的利用%Estimation of Groundwater Use of Winter Wheat Using H218O Signatures; A Preliminary Study

    Institute of Scientific and Technical Information of China (English)

    苑晶晶; 袁国富; 罗毅; 孙晓敏; 张娜

    2009-01-01

    黄河下游引黄灌区地下水埋深通常较浅,冬小麦生长季存在对地下水的利用,论文应用稳定同位素方法研究冬小麦对地下水的利用特征.在中国科学院禹城综合试验站开展实验,通过分析不同灌溉处理条件下土壤水和植物茎水δ18O值之间的关系,应用同位素线性混合模型估算了冬小麦不同生育期对地下水的利用比例.研究结果表明,水的18O信息能很好地揭示冬小麦对不同层次土壤水的利用特征,雨养处理、40%田间持水量处理和现行灌溉制度处理下冬小麦在返青后对地下水的利用分别占其总耗水量的28%、22%和4%左右.研究结果显示适度的灌溉有利于促进作物对不同层次土壤水分的稳定利用,而现行的大田灌溉方式则抑制了作物对地下水资源的利用.

  19. Combined O-(2-[18F]Fluoroethyl)-L-tyrosine (FET) Positron Emission Tomography (PET) and Simultaneous Magnetic Resonance Imaging (MRI) Follow-up in Re-irradiated Recurrent Glioblastoma Patients

    Science.gov (United States)

    2012-12-17

    Glioblastoma; Nervous System Neoplasms; Central Nervous System Neoplasms; Astrocytoma; Glioma; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms by Histologic Type; Neoplasms, Nerve Tissue

  20. Molecular clouds and star formation toward the Galactic plane within 216.25$^{\\rm o}\\le$ l $\\le$218.75$^{\\rm o}$ and $-$0.75$^{\\rm o} \\le$ b $\\le$1.25$^{\\rm o}$

    CERN Document Server

    Gong, Y; Fang, M; Zhang, S B; Su, Y; Yang, J; Jiang, Z B; Xu, Y; Wang, M; Wang, Y; Lu, D R; Sun, J X

    2016-01-01

    As a part of the Milky Way Imaging Scroll Painting (MWISP) survey, we performed a simultaneous 12CO(1-0), 13CO(1-0), C18O(1-0) mapping toward molecular clouds in a region encompassing 3.75 square degrees. We reveal three molecular clouds, the 15 km/s cloud, the 27 km/s cloud, and the 50 km/s cloud, in the surveyed region. The 50 km/s cloud is resolved with an angular resolution of around 1' for the first time. Investigating their morphology and velocity structures, we find that the 27 km/s cloud is likely affected by feedback from the stellar association Mon OB3 and the 50 km/s cloud is characterised by three large expanding molecular shells. The region is mapped in C18O (1-0) for the first time. We discover seven C18O clumps, which are likely to form massive stars, and 15 dust clumps based on the BGPS archival data. Using infrared color-color diagrams, we find 56 Class I and 107 Class II young stellar object (YSO) candidates. According to the distribution of YSO candidates, an overdensity is found around the...

  1. Multibeam collection for KN218: Multibeam data collected aboard Knorr from 2014-05-01 to 2014-05-12, departing from Woods Hole, MA and returning to Woods Hole, MA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  2. Influence of 2-(18F) fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography on recurrent ovarian cancer diagnosis and on selection of patients for secondary cytoreductive surgery

    DEFF Research Database (Denmark)

    Risum, Signe; Høgdall, Claus; Markova, Elena;

    2009-01-01

    The objective of this prospective study was to compare the sensitivities and the specificities of combined 2-(F) fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (PET/CT), abdominal/transvaginal ultrasound (US), and CT for diagnosing recurrent ovarian cancer (OC) and to...... 27 (69%) of 39 patients with solitary tumors on US and in 8 (42%) of 19 patients with solitary tumors on CT. We conclude that the diagnostic value of PET/CT for detecting recurrent OC was higher than those of US and CT and that PET/CT more accurately identified patients with solitary recurrence...

  3. Cooked oatmeal consumption is associated with better diet quality, better nutrient intakes, and reduced risk for central adiposity and obesity in children 2-18 years: NHANES 2001-2010

    OpenAIRE

    O'Neil, Carol E.; Victor L. Fulgoni III; Nicklas, Theresa A.; DiRienzo, Maureen A.

    2015-01-01

    Background: None of the studies of whole grains that have looked either at diet or weight/adiposity measures have focused exclusively on oatmeal.Objective: The objective of this study was to assess the association between oatmeal consumption and nutrient intake, diet quality, and weight/adiposity of children aged 2–18.Design: A nationally representative sample of children aged 2–18 (N=14,690) participating in National Health and Nutrition Examination Survey 2001–2010 was used. Intake was dete...

  4. Comparison of the doubly labeled water (2H2(18)O) method with indirect calorimetry and a nutrient-balance study for simultaneous determination of energy expenditure, water intake, and metabolizable energy intake in preterm infants

    International Nuclear Information System (INIS)

    The doubly labeled water method was compared with indirect calorimetry and a nutrient-balance study for simultaneous determination of rates of CO2 production, energy expenditure, and water intake over 5 days in four preterm infants. Additionally, metabolizable energy (ME) intake estimated using the isotope procedure (as energy expenditure plus an estimate for energy deposition based on weight gain), was compared to ME intake measured in the balance study. Compared to values obtained by traditional methods, calculated CO2 production, energy expenditure, and water intake differed by -1.4 +/- 4.8% (SD), +0.3 +/- 2.6%, and +5.7 +/- 1.4%, respectively; the difference in water intake was significant (p less than 0.05). Calculated ME intakes were 5.3 +/- 19.3% less than measured intakes, but the difference was not significant. These findings indicate that the doubly labeled water method can provide accurate information on rates of CO2 production, energy expenditure, and water intake in preterm infants, but individual estimates of ME intake may be subject to substantial error

  5. Lipidomics and H218O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos

    OpenAIRE

    McDougall, Melissa Q.; Jaewoo Choi; Stevens, Jan F.; Lisa Truong; Tanguay, Robert L.; Traber, Maret G.

    2016-01-01

    We hypothesized that vitamin E (α-tocopherol) is required by the developing embryonic brain to prevent depletion of highly polyunsaturated fatty acids, especially docosahexaenoic acid (DHA, 22:6), the loss of which we predicted would underlie abnormal morphological and behavioral outcomes. Therefore, we fed adult 5D zebrafish (Danio rerio) defined diets without (E−) or with added α-tocopherol (E+, 500 mg RRR-α-tocopheryl acetate/kg diet) for a minimum of 80 days, and then spawned them to obta...

  6. CTD Data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT218-227 during 2010) (NCEI Accession 0087584)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  7. Multiple bone metastases detected on 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography in a breast cancer patient: Case report and literature review

    Directory of Open Access Journals (Sweden)

    Zeki Dostbil

    2012-09-01

    Full Text Available Bone scintigraphy has been widely used to assess skeletal metastasis in patients with breast cancer. 18F-FDGPET/CT is another imaging modality that has gained previously wide use to determine metastasis based on increased glucose metabolism in malignant cells. Generally, these two modalities give similar results in evaluation of bone metastasis of breast cancer. In this breast cancer case, 99mTc-MDP bone scintigraphy showed normal findings in regards to skeletal metastasis while 18FFDG-PET/CT, contrast-enhanced CT and MRI revealed multiple metastatic focuses. J Clin Exp Invest 2012; 3 (3: 426-429Key words: 18F-fluorodeoxyglucose, bone metastasis, bone scintigraphy, positron emission tomography

  8. Subtask 2.18 - Advancing CO2 Capture Technology: Partnership for CO2 Capture (PCO2C) Phase III

    Energy Technology Data Exchange (ETDEWEB)

    Kay, John; Azenkeng, Alexander; Fiala, Nathan; Jensen, Melanie; Laumb, Jason; Leroux, Kerryanne; McCollor, Donald; Stanislowski, Joshua; Tolbert, Scott; Curran, Tyler

    2016-03-31

    Industries and utilities continue to investigate ways to decrease their carbon footprint. Carbon capture and storage (CCS) can enable existing power generation facilities to meet the current national CO2 reduction goals. The Partnership for CO2 Capture Phase III focused on several important research areas in an effort to find ways to decrease the cost of capture across both precombustion and postcombustion platforms. Two flue gas pretreatment technologies for postcombustion capture, an SO2 reduction scrubbing technology from Cansolv Technologies Inc. and the Tri-Mer filtration technology that combines particulate, NOx, and SO2 control, were evaluated on the Energy & Environmental Research Center’s (EERC’s) pilot-scale test system. Pretreating the flue gas should enable more efficient, and therefore less expensive, CO2 capture. Both technologies were found to be effective in pretreating flue gas prior to CO2 capture. Two new postcombustion capture solvents were tested, one from the Korea Carbon Capture and Sequestration R&D Center (KCRC) and one from CO2 Solutions Incorporated. Both of these solvents showed the ability to capture CO2 while requiring less regeneration energy, which would reduce the cost of capture. Hydrogen separation membranes from Commonwealth Scientific and Industrial Research Organisation were evaluated through precombustion testing. They are composed of vanadium alloy, which is less expensive than the palladium alloys that are typically used. Their performance was comparable to that of other membranes that have been tested at the EERC. Aspen Plus® software was used to model the KCRC and CO2 Solutions solvents and found that they would result in significantly improved overall plant performance. The modeling effort also showed that the parasitic steam load at partial capture of 45% is less than half that of 90% overall capture, indicating savings that could be accrued if 90% capture is not required. Modeling of three regional power plants using the Carnegie Mellon Integrated Environmental Control Model showed that, among other things, the use of a bypass during partial capture may minimize the size of the capture tower(s) and result in a slight reduction in the revenue required to operate the capture facility. The results reinforced that a one-size-fits-all approach cannot be taken to adding capture to a power plant. Laboratory testing indicated that Fourier transform infrared spectroscopy could be used to continuously sample stack emissions at CO2 capture facilities to detect and quantify any residual amine or its degradation products, particularly nitrosamines. The information gathered during Phase III is important for utility stakeholders as they determine how to reduce their CO2 emissions in a carbon-constrained world. This subtask was funded through the EERC–U.S. Department of Energy (DOE) Joint Program on Research and Development for Fossil Energy-Related Resources Cooperative Agreement No. DE-FC26-08NT43291. Nonfederal funding was provided by the North Dakota Industrial Commission, PPL Montana, Nebraska Public Power District, Tri-Mer Corporation, Montana–Dakota Utilities Co., Basin Electric Power Cooperative, KCRC/Korean Institute of Energy Research, Cansolv Technologies, and CO2 Solutions, Inc.

  9. Information Literacy Programs and Research: Reflections on "Information Literacy Programs and Research: An International Review" by Christine Bruce. 2000. "The Australian Library Journal" 49 no. 3: 209-218.

    Science.gov (United States)

    Bruce, Christine

    2011-01-01

    Although in the late 1990s there was much discussion as to whether the idea of information literacy was necessary or had longevity, global interest in the phenomenon has increased rather than diminished. Information literacy standards have been developed and become widely accepted in educational systems. Research centres for information literacy…

  10. 77 FR 26356 - Petition for Waiver of Compliance

    Science.gov (United States)

    2012-05-03

    ... requested, exempting onboard I-ETMS equipment from the requirements of Sections 218.51, 218.53, 218.55, 218..., turning on, and turning off the onboard equipment. NS also needs the flexibility to permanently disable or... onboard, non-I-ETMS-equipped locomotives operating in I-ETMS territory shall not be construed as an...

  11. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  12. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  13. Production cross section of At radionuclides from $^{7}$Li+$^{\\textrm{nat}}$Pb and $^{9}$Be+$^{\\textrm{nat}}$Tl reactions

    CERN Document Server

    Maiti, Moumita

    2011-01-01

    Earlier we reported theoretical studies on the probable production of astatine radionuclides from $^{6,7}$Li and $^{9}$Be-induced reactions on natural lead and thalliun targets, respectively. For the first time, in this report, production of astatine radionuclides has been investigated experimentally with two heavy ion induced reactions: $^{9}$Be+$^{\\textrm{nat}}$Tl and $^{7}$Li+$^{\\textrm{nat}}$Pb. Formation cross sections of the evaporation residues, $^{207,208,209,210}$At, produced in (HI, xn) channel, have been measured by the stacked-foil technique followed by the off-line $\\gamma$-spectrometry at the low incident energies ($<$50 MeV). Measured excitation functions have been explained in terms of compound nuclear reaction mechanism using Weisskopf-Ewing and Hauser-Feshbach model. Absolute cross section values are lower than the respective theoretical predictions.

  14. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  15. 12 CFR 250.221 - Issuance and sale of short-term debt obligations by bank holding companies.

    Science.gov (United States)

    2010-01-01

    ... Bulletin 485, 12 CFR 218.104, 12 CFR 218.105 and 12 CFR 218.101.) (e) In reaching this conclusion, the... (17 CFR 231.4412). The reasons for such exemption, taken together with the abuses that gave rise to... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Issuance and sale of short-term...

  16. Dicty_cDB: [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VF (Link to library) VFC218 (Link to dictyBase) - - - Contig-U12091-1 VFC218P (Link... to Original site) VFC218F 487 VFC218Z 391 VFC218P 878 - - Show VFC218 Library VF (Link to library) Clone ID VFC218 (Link to dict...yBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U12091-1 Original site URL http://dict... J03515 |J03515.1 Slime mold (D.discoideum) severin mRNA, complete cds. 856 0.0 3 U66525 |U66525.1 Dictyoste...mic 24.0 %: mitochondrial 20.0 %: nuclear 4.0 %: peroxisomal >> prediction for VF

  17. Experimental performance of ozone-safe alternative refrigerants: Experimental performance comparisons of R32, R125, R143a, R218, R134a, R152a, R124, R142b, RC318 and R143 in a refrigeration circuit

    Science.gov (United States)

    Sand, James R.; Vineyard, Edward A.; Nowak, Richard J.

    1990-02-01

    Several compounds proposed as near term or longer range substitutes for the regulated chlorofluorocarbon (CFC) refrigerants were tested in a breadboard vapor-compression circuit, and their performance was evaluated relative to more commonly used refrigerants. The limited physical property information available in the literature for these alternative compounds was used to fit an equation of state so coefficients of performance (COPs) and capacities calculated from refrigerant property subroutines could be compared to those obtained experimentally. Comparisons of measured and modeled performance are given for 11 alternatives and for R22, R12, and R114. Estimates of compressor efficiency with each refrigerant are provided. Several of the alternatives exhibited better performance than the more widely used refrigerants at some or all of the conditions tested. Ozone-safe, alternative refrigerants that performed better than CFC counterparts at selected conditions are R152a, R143a, R134a, R134, and R142b.

  18. Potencialidades e desafios para a aplicação da escala de risco familiar na atenção primária em saúdedoi: 10.12662/2317-3076jhbs.v3i4.201.p218-223.2015

    Directory of Open Access Journals (Sweden)

    Francisco Maximiano Nunes Moura

    2015-12-01

    Full Text Available Introdução: A Estratégia Saúde da Família (ESF constitui-se como elemento fundamental para a organização da Atenção Básica (AB, realizando ações como a visita domiciliar, visando à garantia de acesso aos serviços de saúde. Objetivo: Analisar as potencialidades e desafios para a aplicação da Escala de Risco Familiar de Coelho e Savassi (ERF-CS como instrumento para o planejamento dos atendimentos domiciliares no âmbito da AB. Métodos:O trabalho foi desenvolvido em uma Unidade de Saúde do município de Fortaleza. Para tanto, utilizou os dados do Sistema de Informação da Atenção Básica (SIAB de cinco agentes comunitários de saúde que visitaram 48 domicílios durante o mês de agosto de 2015. Resultados: Dentre as potencialidades, destacou-se a necessidade de um olhar diferenciado para o território e seus sujeitos. Como desafios, a falta de atualização da Ficha A dificultou a efetivação da ERF-CS. Conclusão: Tal estratégia carece de novas análises visando o fortalecimento da Atenção Básica.

  19. 13b,13c-Di-2-pyridyl-5,7,12,13b,13c,14-hexahydro-6H,13H-5a,6a,12a,13a-tetraazabenz[5,6]azuleno[2,1,8-ija]benz[f]azulene-6,13-dione methanol hemisolvate

    Directory of Open Access Journals (Sweden)

    Lin Li

    2008-01-01

    Full Text Available The title compound, C30H24N6O2·0.5CH3OH, a glycoluril derivative with two pyridine substituents on the convex face of the glycoluril system, is an important intermediate for the synthesis of more complex glycoluril derivatives. The compound crystallizes with two independent molecules in the asymmetric unit, one of which exhibits disorder of one benzene ring over two orientations with refined site occupancy factors 0.65 (4:0.35 (4. The crystal structure contains several short C—H...O contacts, and the methanol molecule forms an O—H...O hydrogen bond to one of the glycoluril molecules.

  20. Inclusive measurement of (p,πsup(-)xn) double charge exchange reactions on bismuth from threshold to 800 MeV

    International Nuclear Information System (INIS)

    The energy dependence of the total angle-integrated cross section for the production of astatine isotopes from (p,πsup(-)xn) double charge exchange reactions on bismuth (sup(209)Bi) was measured from 120 to 800 MeV using activation and radiochemical techniques. Chemical yields were estimated by direct radioassaying of sup(211)At activity in thin (approximately 1 mg/cmsup(2)), irradiated bismuth targets. Calculations of the contributions of secondary (2-step) reactions to these measured astatine yields were performed, based partially upon the observed sup(211)At activity although even at the highest energies, the contribution to products lighter than sup(207)At was negligible. These data for products with as many as 7 neutrons removed from the doubly coherent product (sup(210)At) display nearby gaussian shapes for the mass distributions of the astatine residues with the maximum occurring for about sup(204)At. The most probable momentum transfer deduced from these distributions for the initial πsup(-) production step was 335 MeV/c. The observed excitation functions display a behaviour similar to that observed for the yield of sup(210)Po from a (p,πsup(O)) reaction on sup(209)Bi, but radically different from that observed for inclusive πsup(-) reactions on a heavy nucleus. These data are discussed in terms of recent theoretical approaches to negative pion production from bismuth. In addition, a simple, schematic model is developed to treat the rapidly decreasing percentage of the total inclusive πsup(-) emission which is observed for this double charge exchange reaction. This model reflects the capacity of a nucleus to a source of internal energetic protons

  1. Human radiation studies: Remembering the early years: Oral history of Dr. Patricia Wallace Durbin, Ph.D., conducted November 11, 1994

    International Nuclear Information System (INIS)

    This report is a transcript of an interview of Dr. Patricia Wallace Durbin by representatives of the US DOE Office of Human Radiation Research. Dr. Durbin was selected for this interview because of her knowledge of the human plutonium injections and her recollections of key figures, especially Joseph Hamilton. After a brief biographical sketch Dr. Durbin discusses her loss of research funding from DOE, her recollections concerning research into strontium metabolism as part of Project Sunshine, her recollections relating to the rationale for studies of human metabolism of radionuclides, her remembrances of Dr. Hamilton's Astatine and Plutonium research, and her experiences in gathering archival records concerning these researches

  2. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    OpenAIRE

    BAYRAM, Ali

    1998-01-01

    In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 1...

  3. Alpha-decay studies of the new isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At

    CERN Document Server

    Kettunen, H; Grahn, T; Greenlees, P T; Jones, P; Julin, R; Juutinen, S; Keenan, A; Kuusiniemi, P; Leino, M; Leppaenen, A P; Nieminen, P; Pakarinen, J; Rahkila, P; Uusitalo, J

    2003-01-01

    Detailed alpha-decay studies have been performed for the neutron-deficient isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At. The nuclei were produced in fusion-evaporation reactions of sup 5 sup 4 Fe and sup 5 sup 6 Fe ions with a sup 1 sup 4 sup 1 Pr target. The fusion products were separated in-flight using a gas-filled recoil separator and implanted into a position-sensitive silicon detector. The isotopes were identified using position, time and energy correlations between the implants and subsequent alpha-decays. Three alpha-decaying states were identified for sup 1 sup 9 sup 3 At and two for sup 1 sup 9 sup 1 At. The spin and parity of the initial states in the astatine isotopes were deduced based on unhindered alpha-decays to states in the bismuth daughter nuclei. In both astatine isotopes the 1/2 sup + intruder state was determined to be the ground state and a 7/2 sup - state to be the first-excited state. In sup 1 sup 9 sup 3 At the alpha-decay of the 13/2 sup + state was observed in coincidence...

  4. Rationalization of the solvation effects on the AtO+ ground-state change.

    Science.gov (United States)

    Ayed, Tahra; Réal, Florent; Montavon, Gilles; Galland, Nicolas

    2013-09-12

    (211)At radionuclide is of considerable interest as a radiotherapeutic agent for targeted alpha therapy in nuclear medicine, but major obstacles remain because the basic chemistry of astatine (At) is not well understood. The AtO(+) cationic form might be currently used for (211)At-labeling protocols in aqueous solution and has proved to readily react with inorganic/organic ligands. But AtO(+) reactivity must be hindered at first glance by spin restriction quantum rules: the ground state of the free cation has a dominant triplet character. Investigating AtO(+) clustered with an increasing number of water molecules and using various flavors of relativistic quantum methods, we found that AtO(+) adopts in solution a Kramers restricted closed-shell configuration resembling a scalar-relativistic singlet. The ground-state change was traced back to strong interactions, namely, attractive electrostatic interactions and charge transfer, with water molecules of the first solvation shell that lift up the degeneracy of the frontier π* molecular orbitals (MOs). This peculiarity brings an alternative explanation to the highly variable reproducibility reported for some astatine reactions: depending on the production protocols (with distillation in gas-phase or "wet chemistry" extraction), (211)At may or may not readily react. PMID:23944251

  5. Low Response Rate and Other Factors Render Academic Health Science Library System Study Ungeneralizable. A Review of: Folb, B. L., Wessel, C. B., & Czechowski, L. J. (2011. Clinical and academic use of electronic and print books: The Health Sciences Library System e-book study at the University of Pittsburgh. Journal of the Medical Library Association, 99(3, 218-228. doi:10.3163/1536-5050.99.3.009

    Directory of Open Access Journals (Sweden)

    Maria Melssen

    2012-06-01

    Full Text Available Objective – To determine the factors, barriersand facilitators, preference, and intended useof e-book compared to print book usage by allpatrons in a health science library system,which serves a university with health sciencedegree programs and a hospital system.Design – Two online surveys.Setting – University of Pittsburgh HealthSciences Library System, which includes theUniversity of Pittsburgh’s six schools of healthsciences (medicine, dental medicine, nursing,pharmacy, public health, and rehabilitationand the University of Pittsburgh MedicalCenter hospitals and programs.Subjects – All health sciences library systemusrers, including faculty, researchers, clinicians,residents, fellows, employees, and students.Methods – Two versions of the survey weredeployed in 2009 using Opinio. There were 46questions for the University of PittsburghMedical Center (UPMC survey and 47questions for the University of Pittsburgh (Pittsurvey. The surveys were pilot tested byHealth Sciences Library System (HSLSlibrarians and graduate students in a surveymethods class. The survey was edited based onthe feedback provided and receivedinstitutional review board approval as anexempt study.A total of 5,292 email addresses wererandomly selected by SPSS from a pool of 9,472 UPMC and Pitt patrons registered with a HSLS remote access password; 2,684 patrons from UPMC and 2,608 patrons from Pitt were selected. HSLS librarians were excluded from the survey. Participants were emailed a link to the survey in March of 2009. Three email reminders were sent at five day intervals. Data was collected for 22 days and exported from Opinio to SPSS statistics software. Survey results were analyzed using basic descriptive statistics and cross-tabulations.Main Results – Of the 5,292 emails sent, 979 surveys were submitted and 871 were completed fully. The 108 partially completed the surveys were analyzed using pair wise deletion. All HSLS user groups were represented and all rated their confidence in computer skills high. The mean age of respondents was 39.9 with the majority of respondents being female.Of the 871 completed surveys, over half (55.4% of the respondents reported using HSLS e-books: 66.7% men and 54.9% women. HSLS e-books were used for in-depth reading by 53.4% of men and 36.8% of women. At UPMC, 70% of attending physicians, interns, residents, fellows, and Pitt postdoctoral/fellows use HSLS e-books. The primary use of the e-books was for clinical care, by 75.3% of attending physicians; 86% of interns, residents, and fellows; and 38.9% of nurses. HSLS e-books are also used by 61.8% of respiratory care and physical therapists, 28.6% of administrators, and 56.8% of researchers.At Pitt, 73% of postdoctoral students or fellows and 64.7% of faculty used HSLS e-books. The primary use of the e-books was to support research. 76.5% of postdoctoral students and fellows and 54.1% of faculty used e-books for this purpose. Only 21.3% of faculty assigned e-books for class readings. Though 14% of undergraduate and 33.5% of medical students responded that they had been assigned readings from e-books, 51% of undergraduates and 62.1% of graduate and medical students used an e-book to complete an assignment.Over half (65.5% of respondents saw information about HSLS e-books on the HSLS website and 55.4% of respondents used an HSLS e-book. When using an e-book, 56.6% look up brief, factual information while 41.9% use e-books for in-depth study.Uses of HSLS e-book search tools were rated: the federated full text search tool was used by 67.2% of respondents and 74.3% of those who use this tool rated it as moderately to extremely useful. Google books and the library catalog were also rated moderately to extremely useful by respondents. The catalog received the lowest rating of the HSLS e-book search tools.More respondents (95.4% use the library’s website than come to the physical library (63.8%; however, 66.9% say they use both the website and physical library. Of the 63.8% of respondents who came to one of the HSLS libraries, 67.2% borrow

  6. Actiniarian Sea anemone fauna of India

    Digital Repository Service at National Institute of Oceanography (India)

    Parulekar, A.H.

    stream_size 11 stream_content_type text/plain stream_name Mar_Biofouling_Power_Plants_1990_218.pdf.txt stream_source_info Mar_Biofouling_Power_Plants_1990_218.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset...

  7. CAN THE STABILITY OF PROTEIN MUTANTS BE PREDICTED BY FREE-ENERGY CALCULATIONS

    NARCIS (Netherlands)

    YUNYU, S; MARK, AE; WANG, CX; HUANG, FH; BERENDSEN, HJC; VANGUNSTEREN, WF

    1993-01-01

    The use of free energy simulation techniques in the study of protein stability is critically evaluated. Results from two simulations of the thermostability mutation Asn218 to Ser218 in Subtilisin are presented. It is shown that components of the free energy change can be highly sensitive to the comp

  8. Dicty_cDB: Contig-U12668-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available s / Plus Query: 13 aaaaagggacttgngagtntgntgatttngatccnaaaccnnnnnnnngnaaaantgntg 72 |||||||||||||||||||||||||...|||||||||||||||| || |||||||||||| Sbjct: 13 aaaaagggacttgngagtntgntgatttngatccnaaaccnttnntttgnaaaantgntg 72 Q...aaaggntntgnntnctggaaancnagncaaggngnttcaa 192 Query: 193 nggccccntnaaangccnatcccctt 218 |||||||||||||||||||||...||||| Sbjct: 193 nggccccntnaaangccnatcccctt 218 >Contig-U11508-1 (Contig-U11508-1Q) /CSM_Contig/Contig-U1150...us Query: 13 aaaaagggacttgngagtntgntgatttngatccnaaaccnnnnnnnngnaaaantgntg 72 ||||

  9. 29 CFR 502.19 - Civil money penalty assessment.

    Science.gov (United States)

    2010-07-01

    ... loss or substantial impairment of one of the senses (sight, hearing, taste, smell, tactile sensation... that is required by sec. 218 of the INA, 20 CFR 655, subpart B, or these regulations constituting a... worker's employment that are required by sec. 218 of the INA, 20 CFR 655, subpart B, or these...

  10. Gclust Server: 201683 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 201683 OSA_@218 Cluster Sequences - 164 no annotation 1 1.00e-80 14.29 0.0 0.0 0.0 0.0 0.0 Show 2016...83 Cluster ID 201683 Sequence ID OSA_@218 Link to cluster sequences Cluster Sequences Link

  11. 26 CFR 31.6413(c)-1 - Special refunds.

    Science.gov (United States)

    2010-04-01

    ... from the employee's remuneration by reason of such agreement has been paid to the district director... such remuneration for services covered by an agreement made pursuant to section 218 of the Social... from an employee's remuneration as a result of an agreement made pursuant to section 218 of the...

  12. Late quaternary fluctuations in carbonate and carbonate ion content in the northern Indian ocean

    Digital Repository Service at National Institute of Oceanography (India)

    Naik, S.S.

    /21 and SK218/A: Core AS9/21 was recovered from the Arabian Sea, nd core SK218/A, was recovered from the Bay of Bengal (Table 3, Fig. 9). Both cores lie in two unique environments but along a similar latiudinal transect. Both cores cover a time span of 25...

  13. 77 FR 19109 - Bacillus Pumilus Strain GHA 180; Exemption From the Requirement of a Tolerance

    Science.gov (United States)

    2012-03-30

    ...: Fundamentals and Frontiers. American Society for Microbiology, Washington, DC 5. World Health Organization...- 5805. II. Background and Statutory Findings In the Federal Register of September 30, 2010 (75 FR 60452... Technical Grade of the Active Ingredient (TGAI) (2.18 mg/L) for 4 hours (LC 50 >2.18 mg/L, EPA...

  14. Tourism and the coastal zone

    Digital Repository Service at National Institute of Oceanography (India)

    Mascarenhas, A.

    stream_size 1 stream_content_type text/plain stream_name Fish_Curry_Rice_2002_218.pdf.txt stream_source_info Fish_Curry_Rice_2002_218.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  15. 76 FR 50268 - Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance

    Science.gov (United States)

    2011-08-12

    ... Adjustment Assistance TA-W-73,218 International Business Machines Corporation, ITD Business Unit, Division 7... Reporting to Armonk, NY TA-W-73,218A International Business Machines Corporation, Web Strategy and... Adjustment Assistance on May 14, 2010, applicable to workers of International Business Machines...

  16. Tumor diagnosis by PET: potential of seven tracers examined in five experimental tumors including an artificial metastasis model

    International Nuclear Information System (INIS)

    The potential of seven tracers for the metabolic imaging of tumors by positron emission tomography was studied using five experimental tumor models. The tracers examined were 2-deoxy-2-[18F]fluoro-D-glucose([18F]FDG), 2-deoxy-2-[18F]fluoro-D-galactose (2-[18F]FdGal) and 2-deoxy-2-[18F]fluoro-L-fucose (2-[18F]FdFuc) for investigating energy metabolism. L-[methyl-11C]Methionine ([11C]Met) and 6-[18F]fluoro-L-fucose (6-[18F]FFuc) were used for assessing protein and glycoprotein synthesis, while [3H]thymidine ([3H]Thd) and 2-deoxy-5'-[18F]fluorouridine ([18F]FdUrd) were used to investigate nucleic acid metabolism. (Author)

  17. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

    2013-01-01

    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  18. Development of 211At Chemistry for Labelling Biomolecules

    International Nuclear Information System (INIS)

    Our studies have demonstrated that high recovery of 211At can be obtained using a “wet chemistry” approach to isolation from the bismuth target. We have also demonstrated that direct labelling of antibody-B10 conjugates with 211At can be performed in high yields, and that the astatinated antibodies are stable to in vivo deastatination. While these results will allow us to enter clinical studies with 211At-labelled antibodies, the chemistry associated with 211At is not fully understood. Therefore, it is important that many more basic studies to be conducted with 211At, so the optimal labelling reagent for each type of disease-targeting agent becomes apparent

  19. Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status

    DEFF Research Database (Denmark)

    Lyckesvärd, Madeleine Nordén; Delle, Ulla; Kahu, Helena;

    2014-01-01

    Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ((211)At), concentrated in the thyroid by the same...... levels of γH2AX decreased during the first 24h in both cycling and stationary cultures and complete repair was seen in all cultures but cycling cells exposed to (211)At. Compared to stationary cells alpha particles were more harmful for cycling cultures, an effect also seen at the pChk2 levels...... cultures at a modest level of damage, clearly demonstrating that cell cycle status influences the relative effectiveness of alpha particles....

  20. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    Directory of Open Access Journals (Sweden)

    Ali BAYRAM

    1998-03-01

    Full Text Available In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 10, 50 and 259 mm/min. Strength properties of dual-phase steels were investigated depending on annealing temperature, ratio of martensite and loading rate.

  1. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: bruce.marsh@cern.ch [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others

    2013-12-15

    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  2. Contributions of conserved residues at the gating interface of glycine receptors

    DEFF Research Database (Denmark)

    Pless, Stephan Alexander; Leung, Ada W Y; Galpin, Jason D;

    2011-01-01

    and the in vivo nonsense suppression method to incorporate unnatural amino acids to probe the electrostatic and hydrophobic contributions of five highly conserved side chains near the interface, Glu-53, Phe-145, Asp-148, Phe-187, and Arg-218. Our results suggest a salt bridge between Asp-148 in loop 7 and Arg-218......Rs is not crucial for normal channel function. These findings help decipher the GlyR gating pathway and show that distinct residue interaction patterns exist in different pLGICs. Furthermore, a salt bridge between Asp-148 and Arg-218 would provide a possible mechanistic explanation for the pathophysiologically...

  3. Tolerance to various toxicants by marine bacteria highly resistant to mercury

    Digital Repository Service at National Institute of Oceanography (India)

    De, J.; Ramaiah, N.; Mesquita, A.; Verlecar, X.N.

    Microbiol. Lett. 100: 197-204. Gerlach, A. S. (1981). Marine Pollution. Diagnosis and Therapy. pp. 218. Springer-Verlag Berlin Heidelberg New York. Hideomi N., Ishikawa, T., Yasunaga, S., Kondo, I., and Mitsuhasi, S. (1977). Frequency of heavy...

  4. Dicty_cDB: Contig-U15346-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available HN218Z ,1243,1475 Translated Amino Acid sequence llaywxnnsnnnnsnnninks*tkkeiniimvi*nipl**nswwifik*sk*yikertsl *fcscam... Frame B: llaywxnnsnnnnsnnninks*tkkeiniimvi*nipl**nswwifik*sk*yikertsl *fcscamgt*

  5. Läänemere-ruum uurimisainese ja mõistena / Juhan Kreem

    Index Scriptorium Estoniae

    Kreem, Juhan

    2007-01-01

    Rets. rmt.: The Baltic as a Multicultural World : Sea, Region and Peoples. Marko Lehti (ed.). (The Baltic Sea Region : Nordic Dimensions - European Perspectives 4). Berliner Wissenschafts-Verlag, Berlin, 2005. 218 lk.

  6. 77 FR 4582 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Science.gov (United States)

    2012-01-30

    ..., 12000029 IOWA Buena Vista County Sioux Theatre, (Movie Theaters of Iowa MPS) 218 Main St., Sioux Rapids..., & Library Aves., & W. 25th St., Cleveland, 12000031 Shaker Farm Historic District, Roughly bounded...

  7. Distribution and drug sensitivity of pathogens in diabetic foot ulcer secretions

    Institute of Scientific and Technical Information of China (English)

    李惠琴

    2013-01-01

    Objective To investigate the distribution and drug sensitivity of pathogens isolated from diabetic foot ulcer(DFU) secretions. Methods A retrospective study was carried out on the distribution and drug sensitivity of pathogens isolated from the secretions of 218 DFU

  8. 77 FR 29981 - Marine Mammals; File No. 17086

    Science.gov (United States)

    2012-05-21

    ... was published in the Federal Register (77 FR 9627) that a request for a permit to conduct research on... to Robin Baird, Ph.D., Cascadia Research, 218\\1/2\\ W. 4th Avenue, Olympia, WA 98501, to...

  9. 77 FR 35424 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Science.gov (United States)

    2012-06-13

    ... review, we cannot guarantee that we will be able to do so. Dated: May 23, 2012. J. Paul Loether, Chief... Company Paper Mill and Sack Factory, 218 Cleveland St., Chagrin Falls, 12000391 Franklin County...

  10. Choctaw National Wildlife Refuge Natural Community and Rare Plant Survey

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Choctaw National Wildlife Refuge (CNWR) administers approximately 4,218 acres along theTombigbee River in Choctaw County, Alabama (Figure 1). The Refuge contains a...

  11. 77 FR 47337 - Project-Level Predecisional Administrative Review Process

    Science.gov (United States)

    2012-08-08

    ... reduce the threat of destructive wildfires while upholding environmental standards and encouraging early... part 218 on January 9, 2004 (69 FR 1529), followed by a final rule on September 17, 2008 (73 FR...

  12. WEEKLY WATCH

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    OPINION Popular Majors No More China recently issued its first blue paper on employment. Based on 218,000 valid questionnaires returned by college graduates in 2008, the blue paper says that students majoring in law, IT,

  13. 77 FR 66578 - San Bernardino National Forest, Mountaintop Ranger District, CA, Santa Ana Watershed Hazardous...

    Science.gov (United States)

    2012-11-06

    ... under the HFRA will be implemented per 36 Code of Federal Regulations (CFR) 218 for this project... hand or machine piling and burning. Wood slash piles would be burned, once the wood has dried,...

  14. Complete Genome Sequence of Xanthomonas arboricola pv. juglandis 417, a Copper-Resistant Strain Isolated from Juglans regia L.

    Science.gov (United States)

    Pereira, Ulisses P; Gouran, Hossein; Nascimento, Rafael; Adaskaveg, James E; Goulart, Luiz Ricardo; Dandekar, Abhaya M

    2015-01-01

    Here, we report the complete genome sequence of Xanthomonas arboricola pv. juglandis 417, a copper-resistant strain isolated from a blighted walnut fruit (Juglans regia L. cv. Chandler). The genome consists of a single chromosome (5,218 kb).

  15. Data of evolutionary structure change: 1ACLA-2C0PB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1ACLA-2C0PB 1ACL 2C0P A B --SELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPV...PMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGC---NDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDG... 0 1ACL AGLU CA 218 LEU CA 292 1ACL A 1ACLA RNLNCNLNSDEEL

  16. Mineviku varjud / Eerik Purje

    Index Scriptorium Estoniae

    Purje, Eerik, 1927-

    2007-01-01

    rets. rmt.: Soviet deportations in Estonia: impact and legacy : articles and life histories / tlk. Alliki Arro, Madli Puhvel, Lilian Puust; toim. Kristi Kukk, Toivo Raun; eessõna Toivo Raun. Tartu : Tartu Ülikooli Kirjastus, 2007. 218 lk.

  17. BWR refill-reflood program: core spray distribution experimental task plan

    Energy Technology Data Exchange (ETDEWEB)

    Eckert, T.

    1981-02-01

    An experimental task plan for the BWR/4 core spray task of the Refill-Reflood Test Program is presented. The test program will provide core spray distribution data for a 30 degree sector of the BWR/4 and 5-218 design. This design uses different nozzle types and different sparger elevations than the BWR/6-218 design which was tested previously. Test parameter ranges are specified; individual tests are defined; and measurement and data utilization plans are defined.

  18. AcEST: DK962608 [AcEST

    Lifescience Database Archive (English)

    Full Text Available protein OS=Oryza... 218 2e-55 tr|A8I629|A8I629_CHLRE Non-discriminatory gln-glu-trna synthetas... 218 4e-55...EVEAE 693 LPP Y GKW A+ E++ E Sbjct: 166 MQLPPVYMGKWGTASDAEIQQE 187 >tr|A8I629|A8I629_CHLRE Non-discriminat...ory gln-glu-trna synthetase OS=Chlamydomonas reinhardtii GN=GTS2 PE=3 SV=1 Length =

  19. Genetic and bibliographic information: ACTG1 [GenLibi

    Lifescience Database Archive (English)

    Full Text Available earing loss Otorhinolaryngologic Diseases (C09) > Ear Diseases (C09.218) > Hearing Disorders (C09.218.458) > Hearing...ion Disorders (C10.597.751) > Hearing Disorders (C10.597.751.418) > Hearing Loss ...rologic Manifestations (C23.888.592) > Sensation Disorders (C23.888.592.763) > Hearing Disorders (C23.888.592.763.393) > Hearing Loss (C23.888.592.763.393.341) 00A0313755 ...

  20. Improvement of an l-Leucine-Producing Mutant of Brevibacterium lactofermentum 2256 by Genetically Desensitizing It to α-Acetohydroxy Acid Synthetase

    OpenAIRE

    Tsuchida, Takayasu; Momose,Haruo

    1986-01-01

    Genetic improvement of l-leucine productivity in strain 218, an ile− 2-thiazolealanine-resistant mutant of Brevibacterium lactofermentum 2256, was attempted. In strain 218, which produced 28 mg of l-leucine per ml from 13% glucose, α-isopropylmalate synthetase was genetically desensitized and derepressed to the effect of l-leucine, whereas α-acetohydroxy acid synthetase remained unaltered, although it could be derepressed phenotypically by limiting the isoleucine concentration in the culture....

  1. Domain Modeling: NP_001074911.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001074911.1 chr19 EXTRACELLULAR REGION OF THE HUMAN RECEPTOR NKP46 c1p6fa_ chr19/NP_001074911....1/NP_001074911.1_apo_218-419.pdb c1olla_ chr19/NP_001074911.1/NP_001074911.1_holo_218-419.pdb blast 256Y,257K,258E,259G,292Q,293Y,294R,296Y EDO 1 ...

  2. Decreased cerebral α4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer's disease assessed with positron emission tomography

    International Nuclear Information System (INIS)

    Postmortem studies indicate a loss of nicotinic acetylcholine receptor (nAChRs) in Alzheimer's disease (AD). In order to establish whether these changes in the cholinergic system occur at an early stage of AD, we carried out positron emission tomography (PET) with a specific radioligand for the α4β2* nicotinic acetylcholine receptor (α4β2* nAChR) in patients with mild to moderate AD and in patients with amnestic mild cognitive impairment (MCI), who have a high risk to progress to AD. Nine patients with moderate AD, eight patients with MCI and seven age-matched healthy controls underwent 2-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[18F]FA-85380) PET. After coregistration with individual magnetic resonance imaging the binding potential (BPND) of 2-[18F]FA-85380 was calculated using either the corpus callosum or the cerebellum as reference regions. PET data were analysed by region of interest analysis and by voxel-based analysis. Both patients with AD and MCI showed a significant reduction in 2-[18F]FA-85380 BPND in typical AD-affected brain regions. Thereby, the corpus callosum was identified as the most suitable reference region. The 2-[18F]FA-85380 BPND correlated with the severity of cognitive impairment. Only MCI patients that converted to AD in the later course (n = 5) had a reduction in 2-[18F]FA-85380 BPND. 2-[18F]FA-85380 PET appears to be a sensitive and feasible tool for the detection of a reduction in α4β2* nAChRs which seems to be an early event in AD. In addition, 2-[18F]FA-85380 PET might give prognostic information about a conversion from MCI to AD. (orig.)

  3. Transport and deposition of nano-particles. Application to the free action of short-lived radon daughters; Transport et depot des aerosols nanometriques. Application a la fraction libre des descendants a vie courte du radon

    Energy Technology Data Exchange (ETDEWEB)

    Malet, J

    1997-10-10

    Short-lived radon daughters ({sup 218}Po, {sup 214}Pb, {sup 214}Bi, and {sup 214}Po) are important contributors to the natural average annual individual dose. The models describing the evolution of these aerosol in a house depend critically on a parameter, the {sup 218}Po deposition velocity, which, although aerosol deposition has been extensively studied, is poorly known. A numerical and experimental study is thus carried out for a simple case: deposition in a cylindrical tube under laminar flow condition. The numerical results help understanding the difference between the transport and deposition of these radionuclides and those of non radioactive aerosols. Comparison of these well environment does not give satisfactory correlation, requiring the study of phenomena that may affect deposition. The first of these is the possible variation in the e {sup 218}Po diffusion coefficient. Furthermore, experiments coupled with numerical calculations show that this variation could be due to {sup 218}Po neutralization. The second phenomenon concerns the effect of the surface type, which is also shown experimentally. By modelling the neutralization and using results with a piratically smooth surface, good numerical/experimental correlations are obtained. Understanding this simple case than makes possible studying a more complex case: deposition in controlled turbulent flow. Two theories are thus experimentally validated. In addition, a {sup 218}Po deposition velocity representative of our experimental conditions is determined. Finally, we report a feasibility study of radon daughters transport and deposition in a ventilated chamber taking into account all the involved phenomena. (author)

  4. Cyclic nucleotide dependent dephosphorylation of regulator of G-protein signaling 18 in human platelets.

    LENUS (Irish Health Repository)

    Gegenbauer, Kristina

    2013-11-01

    Regulator of G-protein signaling 18 (RGS18) is a GTPase-activating protein that turns off Gq signaling in platelets. RGS18 is regulated by binding to the adaptor protein 14-3-3 via phosphorylated serine residues S49 and S218 on RGS18. In this study we confirm that thrombin, thromboxane A2, or ADP stimulate the interaction of RGS18 and 14-3-3 by increasing the phosphorylation of S49. Cyclic AMP- and cyclic GMP-dependent kinases (PKA, PKG) inhibit the interaction of RGS18 and 14-3-3 by phosphorylating S216. To understand the effect of S216 phosphorylation we studied the phosphorylation kinetics of S49, S216, and S218 using Phos-tag gels and phosphorylation site-specific antibodies in transfected cells and in platelets. Cyclic nucleotide-induced detachment of 14-3-3 from RGS18 coincides initially with double phosphorylation of S216 and S218. This is followed by dephosphorylation of S49 and S218. Dephosphorylation of S49 and S218 might be mediated by protein phosphatase 1 (PP1) which is linked to RGS18 by the regulatory subunit PPP1R9B (spinophilin). We conclude that PKA and PKG induced S216 phosphorylation triggers the dephosphorylation of the 14-3-3 binding sites of RGS18 in platelets.

  5. 222Rn, 220Rn and Progeny Measured in a Limestone Cave and the Associated Radiation Dose

    International Nuclear Information System (INIS)

    Concentrations of radon, thoron and the attached and unattached fractions of the short lived alpha emitting decay progeny were measured at different locations in a limestone cave by means of CR-39 and LR-115 type II solid state nuclear track detectors in order to assess the dose due to inhalation. The committed equivalent doses per hour of exposure due to the attached and unattached fractions of 218Po and 214Po were evaluated in different tissues of the respiratory tract. The influence of the activity of the attached and unattached fractions of 218Po and 214Po and the mass of the tissue on the committed equivalent dose per hour of exposure was investigated. The annual committed effective doses due to the attached and unattached fractions of 218Po and 214Po were determined. A maximum value of 1.7 mSv was found for workers spending 1 h/d during the summer months inside the cave. (author)

  6. The Atacama Cosmology Telescope: Cross Correlation with Planck maps

    CERN Document Server

    Louis, Thibaut; Hasselfield, Matthew; Bond, J Richard; Calabrese, Erminia; Das, Sudeep; Devlin, Mark J; Dunkley, Joanna; Dünner, Rolando; Gralla, Megan; Hajian, Amir; Hincks, Adam D; Hlozek, Renée; Huffenberger, Kevin; Infante, Leopoldo; Kosowsky, Arthur; Marriage, Tobias A; Moodley, Kavilan; Næss, Sigurd; Niemack, Michael D; Nolta, Michael R; Page, Lyman A; Partridge, Bruce; Sehgal, Neelima; Sievers, Jonathan L; Spergel, David N; Staggs, Suzanne T; Walter, Benjamin Z; Wollack, Edward J

    2014-01-01

    We present the temperature power spectrum of the Cosmic Microwave Background obtained by cross-correlating maps from the Atacama Cosmology Telescope (ACT) at 148 and 218 GHz with maps from the Planck satellite at 143 and 217 GHz, in two overlapping regions covering 592 square degrees. We find excellent agreement between the two datasets at both frequencies, quantified using the variance of the residuals between the ACT power spectra and the ACTxPlanck cross-spectra. We use these cross-correlations to calibrate the ACT data at 148 and 218 GHz, to 0.7% and 2% precision respectively. We find no evidence for anisotropy in the calibration parameter. We compare the Planck 353 GHz power spectrum with the measured amplitudes of dust and cosmic infrared background (CIB) of ACT data at 148 and 218 GHz. We also compare planet and point source measurements from the two experiments.

  7. The Atacama Cosmology Telescope: cross correlation with Planck maps

    Energy Technology Data Exchange (ETDEWEB)

    Louis, Thibaut; Calabrese, Erminia; Dunkley, Joanna; Næss, Sigurd [Department of Astrophysics, Oxford University, Oxford OX1 3RH (United Kingdom); Addison, Graeme E.; Hincks, Adam D. [Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z4 (Canada); Hasselfield, Matthew; Hlozek, Renée [Department of Astrophysical Sciences, Peyton Hall, Princeton University, Princeton, NJ 08544 (United States); Bond, J. Richard; Hajian, Amir [Canadian Institute for Theoretical Astrophysics, University of Toronto, Toronto, ON M5S 3H8 (Canada); Das, Sudeep [Argonne National Laboratory, 9700 S. Cass Ave., Lemont, IL 60439 (United States); Devlin, Mark J. [Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104, U.S.A (United States); Dünner, Rolando; Infante, Leopoldo [Departamento de Astronomía y Astrofísica, Facultad de Física, Pontificia Universidad Católica de Chile, Casilla 306, Santiago 22 (Chile); Gralla, Megan; Marriage, Tobias A. [Dept. of Physics and Astronomy, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218-2686 (United States); Huffenberger, Kevin [Department of Physics, Florida State University, Keen Physics Building, 77 Chieftan Way, Tallahassee, Florida (United States); Kosowsky, Arthur [Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA, 15260 (United States); Moodley, Kavilan [Astrophysics and Cosmology Research Unit, School of Mathematical Sciences, University of KwaZulu-Natal, Durban, 4041 (South Africa); Niemack, Michael D., E-mail: Thibaut.Louis@astro.ox.ac.uk [Joseph Henry Laboratories of Physics, Jadwin Hall, Princeton University, Princeton, NJ 08544 (United States); and others

    2014-07-01

    We present the temperature power spectrum of the Cosmic Microwave Background obtained by cross-correlating maps from the Atacama Cosmology Telescope (ACT) at 148 and 218 GHz with maps from the Planck satellite at 143 and 217 GHz, in two overlapping regions covering 592 square degrees. We find excellent agreement between the two datasets at both frequencies, quantified using the variance of the residuals between the ACT power spectra and the ACT × Planck cross-spectra. We use these cross-correlations to measure the calibration of the ACT data at 148 and 218 GHz relative to Planck, to 0.7% and 2% precision respectively. We find no evidence for anisotropy in the calibration parameter. We compare the Planck 353 GHz power spectrum with the measured amplitudes of dust and cosmic infrared background (CIB) of ACT data at 148 and 218 GHz. We also compare planet and point source measurements from the two experiments.

  8. The Atacama Cosmology Telescope: cross correlation with Planck maps

    International Nuclear Information System (INIS)

    We present the temperature power spectrum of the Cosmic Microwave Background obtained by cross-correlating maps from the Atacama Cosmology Telescope (ACT) at 148 and 218 GHz with maps from the Planck satellite at 143 and 217 GHz, in two overlapping regions covering 592 square degrees. We find excellent agreement between the two datasets at both frequencies, quantified using the variance of the residuals between the ACT power spectra and the ACT × Planck cross-spectra. We use these cross-correlations to measure the calibration of the ACT data at 148 and 218 GHz relative to Planck, to 0.7% and 2% precision respectively. We find no evidence for anisotropy in the calibration parameter. We compare the Planck 353 GHz power spectrum with the measured amplitudes of dust and cosmic infrared background (CIB) of ACT data at 148 and 218 GHz. We also compare planet and point source measurements from the two experiments

  9. Carboxylicivirga linearis sp. nov., isolated from a sea cucumber culture pond.

    Science.gov (United States)

    Wang, Feng-Qing; Zhou, Yan-Xia; Lin, Xue-Zheng; Chen, Guan-Jun; Du, Zong-Jun

    2015-10-01

    A yellow-pigmented, Gram-stain-negative and facultatively anaerobic bacterium, designated FB218T, was isolated from a sediment sample collected from a sea cucumber culture pond in Rongcheng, China (36° 54′ 36″ N 122° 14′ 34″ E). Cells of strain FB218T were slender, gliding, catalase-positive and oxidase-negative. Optimal growth occurred at 30 °C, pH 6.5–7.0 and in medium containing 2–3 % (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain FB218T belonged to the genus Carboxylicivirga, family Marinilabiliaceae. The predominant fatty acids were iso-C15 : 0 and anteiso-C15 : 0. MK-7 was the main respiratory quinone. The major polar lipids of strain FB218T were two unidentified lipids and a phospholipid. The genomic DNA G+C content was 40.0 mol%. Based on the distinct phylogenetic position and the combination of physiological and phenotypic characteristics, strain FB218T represents a novel species of the genus Carboxylicivirga, for which the name Carboxylicivirga linearis sp. nov. is proposed. The type strain is FB218T ( = KCTC 42254T = MCCC 1H00106T). An emended description of the genus Carboxylicivirga is also provided. PMID:26297036

  10. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  11. The biokinetics of alpha-particle emitting radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, D.M. [School of Chemistry, Cardiff Univ., Cardiff (United Kingdom); Duffield, J.R. [Faculty of Applied Sciences, Univ. of the West of England, Bristol (United Kingdom)

    2005-07-01

    The past two decades have seen wide interest in the application of alpha-particle emitting radionuclides for targeted endoradiotherapy and a large number of compounds labeled with {sup 211}At (T{sup 1}/{sub 2} 7.21 h), {sup 212}Bi (T{sup 1}/{sub 2} 1 h) or {sup 213}Bi (T{sup 1}/{sub 2} 0.78 h) have been studied. Knowledge of the biokinetic behaviour of such agents is important both for their optimal clinical exploitation and for general radiological protection purposes. Animal studies of the distribution and retention of {sup 211}At compounds, including ionic astatide, substituted aromatic compounds and labelled monoclonal antibodies, have provided new information on the biochemistry of astatine. With respect the thyroid gland the uptake of the astatide ion has been shown to be very much lower than that of the iodide ion. Less information is available for {sup 212}Bi-labelled radiopharmaceuticals. The available data for both {sup 211}At and {sup 212}Bi radiopharmaceuticals are reviewed. Cautious generic biokinetic models for inorganic and simple organic compounds of {sup 211}At and {sup 212}Bi; for [{sup 211}At]-, and [{sup 212}Bi]-biphosphonates and for [{sup 211}At]-, and [{sup 212}Bi]-monoclonal antibodies, are proposed for use in general radiological protection when compound-specific data are not available. (orig.)

  12. Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with {sup 211}At-EGF

    Energy Technology Data Exchange (ETDEWEB)

    Sundberg, Aasa Liljegren; Orlova, Anna; Gedda, Lars; Tolmachev, Vladimir; Carlsson, Joergen [Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala (Sweden); Almqvist, Ylva [Division of Radiology, Uppsala University, Uppsala (Sweden); Blomquist, Erik [Division of Oncology, Uppsala University, Uppsala (Sweden); Jensen, Holger J. [Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Rigshospitalet, Copenhagen (Denmark)

    2003-10-01

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib ['Iressa' (trademark of the AstraZeneca group of companies), ZD1839] increases the cellular uptake of radiolabelled epidermal growth factor (EGF). We investigated gefitinib treatment combined with astatine-211 EGF targeting in vitro using two cell lines expressing high levels of EGFR: A431 (sensitive to gefitinib) and U343MGaCl2:1 (resistant to gefitinib). In both cell lines, the uptake of {sup 211}At-EGF was markedly increased by concomitant treatment with gefitinib. Survival was investigated using both a clonogenic survival assay and a cell growth assay. Combined gefitinib and {sup 211}At-EGF treatment reduced the survival of U343 cells 3.5-fold compared with {sup 211}At-EGF alone. In A431 cells, {sup 211}At-EGF treatment resulted in very low survival, but combined treatment with gefitinib increased the survival by about 20-fold. These results indicate that combined treatment with gefitinib might increase the effect of ligand-mediated radionuclide therapy in gefitinib-resistant tumours and decrease the effect of such therapy in gefitinib-sensitive tumours. (orig.)

  13. Alpha particle emitters in medicine

    International Nuclear Information System (INIS)

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 (211At) and natural bismuth-212 (212Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 (223Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs

  14. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  15. Development of Reagents for Application of At-211 to Targeted Radionuclide Therapy of Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott

    2011-12-23

    This grant covered only a period of 4 months as the major portion of the award was returned to DOE due to an award of funding from NIH that covered the same research objectives. A letter regarding the termination of the research is attached as the last page of the Final Report. The research conducted was limited due to the short period of this grant, but the results obtained in that period are outlined in the Final Report. The studies addressed in the research effort were directed at a problem that is of critical importance to the in vivo application of the alpha-particle emitting radionuclide At-211. That problem, low in vivo stability of many astatinated molecules, severely limits the use of At-211 in therapeutic applications. The advances sought in the studies were expected to expand the types of biomolecules that can be used as carriers of At-211, and provide improved in vivo targeting of the radiation dose compared with the dose delivered to normal tissue.

  16. Tumor immunotargeting using innovative radionuclides.

    Science.gov (United States)

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  17. SPECT assay of radiolabeled monoclonal antibodies. Progress report, September 1, 1992--August 24, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1993-08-20

    The overall goal of this project is to improve the effectiveness of single photon emission computed tomography (SPECT) to image and quantify radiolabeled monoclonal antibodies. During the past year, we have made significant progress toward this goal, and this report summarizes that work. Our efforts have been mainly directed along three fronts. First, we have developed and tested new reconstruction methods including three-dimensional iterative algorithms that model non-uniform attenuation and distance-dependent detector response. Both fan beam and parallel beam collimator geometries have been modeled and novel ways of improving the efficiency of the computationally intensive methods have been introduced. Second, an ultra-high resolution, small field-of-view pinhole collimator has been constructed and evaluated. Reconstructed spatial resolution of 1 to 3 mm (FWHM) has been achieved in phantom scans with a useful field-of-view of 9 to 10 cm. Finally, we have investigated the ability of SPECT to image and quantify astatine-211 distributions. Reconstructed images of phantom data demonstrated quantitative accuracy to within 10% with proper attenuation and scatter compensation.

  18. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  19. Nuclear and chemical data for life sciences

    International Nuclear Information System (INIS)

    Use of reactor produced radionuclides is popular in life sciences. However, cyclotron production of proton rich radionuclides are being more focused in recent times. These radionuclides have already gained attention in various fields, including life sciences, provided they are obtained in pure form. This article is a representative brief of our contributions in generating nuclear data for the production of proton rich radionuclides of terbium, astatine, technetium, ruthenium, cadmium, niobium, zirconium, rhenium, etc., which may have application in clinical, biological, agriculture studies or in basic research. The chemical data required to separate the product isotopes from the corresponding target matrix have been presented along with a few propositions of radiopharmaceuticals. It also emphasizes on the development of simple empirical technique, based on the nuclear reaction model analysis, to generate reliable nuclear data for the estimation of yield and angular distribution of emitted neutrons and light charged particles from light as well as heavy ion induced reactions on thick stopping targets. These data bear utmost important in radiation dosimetry. (author)

  20. Studies of Stable Octupole Deformations in the Radium Region

    CERN Multimedia

    2002-01-01

    The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

  1. Alpha particle emitters in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, D.R.

    1989-09-01

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ({sup 211}At) and natural bismuth-212 ({sup 212}Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ({sup 223}Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

  2. Vaccine Protection against Bacillus cereus-Mediated Respiratory Anthrax-Like Disease in Mice

    OpenAIRE

    Oh, So-Young; Maier, Hannah; Schroeder, Jay; Richter, G. Stefan; Elli, Derek; Musser, James M.; Quenee, Lauriane E.; Missiakas, Dominique M.; Schneewind, Olaf

    2013-01-01

    Bacillus cereus strains harboring a pXO1-like virulence plasmid cause respiratory anthrax-like disease in humans, particularly in welders. We developed mouse models for intraperitoneal as well as aerosol challenge with spores of B. cereus G9241, harboring pBCXO1 and pBC218 virulence plasmids. Compared to wild-type B. cereus G9241, spores with a deletion of the pBCXO1-carried protective antigen gene (pagA1) were severely attenuated, whereas spores with a deletion of the pBC218-carried protecti...

  3. Incorporation of oxygen-18 into secondary alcohols of grasshopper Melanoplus sanguinipes.

    Science.gov (United States)

    Blomquist, G J; Mccain, D C; Jackson, L L

    1975-05-01

    Incorporation of 18-O2 and H2-18-O into the secondary alcohol moiety of wax esters in the grasshopper Melanoplus sanguinipes was determined by mass spectrometry. Results of this study show that oxygen-18 from 18-O2 was incorporated into the secondary alcohol, whereas no incorporation of oxygen-18 from H2-18-O was detected. The data suggest that the reaction, which hydroxylates n-alkanes at or near the center of the carbon chain, involves a mixed function oxidase type enzyme. PMID:1128177

  4. 350药学

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    04031322 350·10药物化学S-(2-18F-氟代乙基)-L-蛋氨酸的合成及其放射药理活性=Synthesis and radiopharmacology of S-(2-18F-fluoroethyl)-L-methionine for tumor imaging[刊,中]/唐刚华(第一军医大学南方医院,广州510515),王明芳,唐小兰,罗磊,甘满权//药学学报.-2003,38(12).-915~918

  5. Gclust Server: 96142 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 96142 Glv_gvip218=narB Cluster Sequences Related Sequences(208) 692 nitrate reducta...se 1 1.00e-35 0.0 0.0 4.0 0.0 0.0 0.0 Show 96142 Cluster ID 96142 Sequence ID Glv_gvip218=narB Link to cluster sequences Clus...tative annotation nitrate reductase Number of Sequences 1 Homologs 1 Clustering t...r of Sequences for each species Glv: 1 Species not appearing in this cluster ATH: 0 OSA: 0 PoTR: 0 PPT: 0 CR

  6. Benzodiazepine receptor and neurotransmitter studies in the brain of suicides

    International Nuclear Information System (INIS)

    The characteristics of benzodiazepine binding sites were studied on frozen sections of hippocampus of 7 suicides and 5 controls subjects, using biochemical and autoradiographic techniques. 3H flunitrazepam was used as ligand, clonazepam and CL 218,872 as displacing agents. Some neurotransmitters or their derivatives were evaluated quantitatively in parallel in the hippocampal tissue by liquid chromatography. The authors observed mainly an increase in the Ki of CL 218,872 subtype I binding sites in suicides, and an increase in % of type I binding sites. Among neurotransmitters, only norepinephrine differed significantly between controls and suicides. 36 references, 3 figures, 1 table

  7. Benzodiazepine receptor and neurotransmitter studies in the brain of suicides

    Energy Technology Data Exchange (ETDEWEB)

    Manchon, M.; Kopp, N.; Rouzioux, J.J.; Lecestre, D.; Deluermoz, S.; Miachon, S.

    1987-12-14

    The characteristics of benzodiazepine binding sites were studied on frozen sections of hippocampus of 7 suicides and 5 controls subjects, using biochemical and autoradiographic techniques. /sup 3/H flunitrazepam was used as ligand, clonazepam and CL 218,872 as displacing agents. Some neurotransmitters or their derivatives were evaluated quantitatively in parallel in the hippocampal tissue by liquid chromatography. The authors observed mainly an increase in the Ki of CL 218,872 subtype I binding sites in suicides, and an increase in % of type I binding sites. Among neurotransmitters, only norepinephrine differed significantly between controls and suicides. 36 references, 3 figures, 1 table.

  8. [18F]Fluorobenzoyllysinepentanedioic Acid Carbamates: New Scaffolds for Positron Emission Tomography (PET) Imaging of Prostate-Specific Membrane Antigen (PSMA)

    OpenAIRE

    Yang, Xing; Mease, Ronnie C.; Pullambhatla, Mrudula; Lisok, Ala; Chen, Ying; Foss, Catherine A.; Wang, Yuchuan; Shallal, Hassan; Edelman, Hannah; Hoye, Adam T.; Attardo, Giorgio; Nimmagadda, Sridhar; Pomper, Martin G.

    2015-01-01

    Radiolabeled urea-based low-molecular weight inhibitors of the prostate-specific membrane antigen (PSMA) are under intense investigation as imaging and therapeutic agents for prostate and other cancers. In an effort to provide agents with less nontarget organ uptake than the ureas, we synthesized four 18F-labeled inhibitors of PSMA based on carbamate scaffolds. 4-Bromo-2-[18F]fluorobenzoyllysineoxypentanedioic acid (OPA) carbamate [18F]23 and 4-iodo-2-[18F]fluorobenzoyllysine OPA carbamate [1...

  9. Low-Level Burial Grounds Dangerous Waste Permit Application design documents

    International Nuclear Information System (INIS)

    This document presents the Functional Design Criteria for trenches to be constructed to receive solid radioactive mixed waste (RMW) from on and offsite generators. The new RMW disposal facilities are considered modifications to or lateral expansion of the existing low-level waste burial grounds. The new facilities upgrade the existing disposal practice for RMW to the minimum technology requirements of the Resource Conservation and Recovery Act. The proposed locations for the two facilities are: 218-E-10 for drag-off-waste packages and, 218-W-4C for non drag-off waste packages

  10. Synaptic Gain-of-Function Effects of Mutant Cav2.1 Channels in a Mouse Model of Familial Hemiplegic Migraine Are Due to Increased Basal [Ca2+]i

    OpenAIRE

    Di Guilmi, Mariano N.; Wang, Tiantian; Inchauspe, Carlota Gonzalez; Forsythe, Ian D; Ferrari, Michel D; van den Maagdenberg, Arn M. J. M.; Borst, J. Gerard G.; Uchitel, Osvaldo D.

    2014-01-01

    Specific missense mutations in the CACNA1A gene, which encodes a subunit of voltage-gated CaV2.1 channels, are associated with familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of common migraine with aura. We used transgenic knock-in (KI) mice harboring the human pathogenic FHM1 mutation S218L to study presynaptic Ca2+ currents, EPSCs, and in vivo activity at the calyx of Held synapse. Whole-cell patch-clamp recordings of presynaptic terminals from S218L KI mice showed a s...

  11. Herschel/HIFI spectroscopy of the intermediate mass protostar NGC 7129 FIRS 2

    DEFF Research Database (Denmark)

    Johnstone, D.; Fich, M.; McCoey, C.;

    2010-01-01

    Herschel/HIFI observations of water from the intermediate mass protostar NGC 7129 FIRS 2 provide a powerful diagnostic of the physical conditions in this star formation environment. Six spectral settings, covering four H216O and two H218O lines, were observed and all but one H218O line were...... detected. The four H216O lines discussed here share a similar morphology: a narrower, ˜6 km s-1, component centered slightly redward of the systemic velocity of NGC 7129 FIRS 2 and a much broader, ˜25 km s-1 component centered blueward and likely associated with powerful outflows. The narrower components...

  12. A RETROSPECTIVE COMPARATIVE-STUDY EVALUATING THE RESULTS OF MILD HYPERTHERMIC VERSUS CONTROLLED NORMOTHERMIC PERFUSION FOR RECURRENT MELANOMA OF THE EXTREMITIES

    NARCIS (Netherlands)

    KLAASE, JM; KROON, BBR; EGGERMONT, AMM; VANGEEL, AN; KOOPS, HS; OLDHOFF, J; LIENARD, D; LEJEUNE, FJ; BERKEL, R; FRANKLIN, HR; HART, AAM

    1995-01-01

    The aim of this study was to investigate the role of mild hyperthermia (39-40 degrees C) in isolated cytostatic perfusion for patients with recurrent melanoma of the extremities. A total of 218 patients treated with mild hyperthermic perfusion was compared to 166 patients perfused under controlled n

  13. Linguistic Markers of Inference Generation While Reading

    Science.gov (United States)

    Clinton, Virginia; Carlson, Sarah E.; Seipel, Ben

    2016-01-01

    Words can be informative linguistic markers of psychological constructs. The purpose of this study is to examine associations between word use and the process of making meaningful connections to a text while reading (i.e., inference generation). To achieve this purpose, think-aloud data from third-fifth grade students (N = 218) reading narrative…

  14. Rose Atoll Site 8P 7/29/1999 10-11M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 8P (14 32.282S, 168 09.218W), between 10 and 11 meters along a permanent transect.

  15. Rose Atoll Site 8P 7/29/1999 23-24M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 8P (14 32.282S, 168 09.218W), between 23 and 24 meters along a permanent transect.

  16. Warm water deuterium fractionation in IRAS 16293-2422 - The high-resolution ALMA and SMA view

    CERN Document Server

    Persson, Magnus V; van Dishoeck, Ewine F

    2012-01-01

    Measuring the water deuterium fractionation in the inner warm regions of low-mass protostars has so far been hampered by poor angular resolution obtainable with single-dish ground- and space-based telescopes. Observations of water isotopologues using (sub)millimeter wavelength interferometers have the potential to shed light on this matter. Observations toward IRAS 16293-2422 of the 5(3,2)-4(4,1) transition of H2-18O at 692.07914 GHz from Atacama Large Millimeter/submillimeter Array (ALMA) as well as the 3(1,3)-2(2,0) of H2-18O at 203.40752 GHz and the 3(1,2)-2(2,1) transition of HDO at 225.89672 GHz from the Submillimeter Array (SMA) are presented. The 692 GHz H2-18O line is seen toward both components of the binary protostar. Toward one of the components, "source B", the line is seen in absorption toward the continuum, slightly red-shifted from the systemic velocity, whereas emission is seen off-source at the systemic velocity. Toward the other component, "source A", the two HDO and H2-18O lines are detecte...

  17. 78 FR 50091 - Notice of Intent To Repatriate Cultural Items: University of Colorado Museum of Natural History...

    Science.gov (United States)

    2013-08-16

    ... written request with information in support of the claim to Jen Shannon, Curator of Cultural Anthropology... items should submit a written request with information in support of the claim to the University of... Shannon, Curator of Cultural Anthropology, University of Colorado Museum of Natural History, 218...

  18. 75 FR 27200 - Amateur Service Rules

    Science.gov (United States)

    2010-05-14

    ...., primary or secondary services), the basic principle is the equality of right to operate. Accordingly... harmful interference to, and must accept interference from, international broadcast stations whose...: (i) The FCC in the Automated Maritime Telecommunications System (AMTS), the 218-219 MHz Service,...

  19. 47 CFR 97.303 - Frequency sharing requirements.

    Science.gov (United States)

    2010-10-01

    ... right to operate. Accordingly, stations of each service in one Region or sub-Region must operate so as... MHz segment must not cause harmful interference to, and must accept interference from, international... authorized by: (i) The FCC in the Automated Maritime Telecommunications System (AMTS), the 218-219...

  20. 78 FR 18481 - Project-Level Predecisional Administrative Review Process

    Science.gov (United States)

    2013-03-27

    ... `everything but the kitchen sink', in order to reserve rights to future objections.'' One respondent asserts... rule was promulgated at 36 CFR part 218 on January 9, 2004 (69 FR 1529), followed by a final rule on September 17, 2008 (73 FR 53705), that incorporated the results of public comment and the knowledge...

  1. 12 CFR 250.401 - Director serving member bank and closed-end investment company being organized.

    Science.gov (United States)

    2010-01-01

    ... that a closed-end company which was in process of organization and was actively engaged in issuing and... investment company being organized. 250.401 Section 250.401 Banks and Banking FEDERAL RESERVE SYSTEM... company being organized. (a) The Board has previously expressed the opinion (§ 218.101) that section 32...

  2. 敬赠读者超级享受(英文)

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Badaling Wild Animals'WorldAdmission Ticket:RMB 90/per person¥50/per person(with this coupon)Date:April 1-December 31,2004Add:Beijing Badaling Great Wall Parking Lot(down from the 18th Exit if going along the Badaling Express Way)Tel:82087951,62014689,62015588-218,223,224,225)

  3. Teaching People to Manage Constraints: Effects on Creative Problem-Solving

    Science.gov (United States)

    Peterson, David R.; Barrett, Jamie D.; Hester, Kimberly S.; Robledo, Issac C.; Hougen, Dean F.; Day, Eric A.; Mumford, Michael D.

    2013-01-01

    Constraints often inhibit creative problem-solving. This study examined the impact of training strategies for managing constraints on creative problem-solving. Undergraduates, 218 in all, were asked to work through 1 to 4 self-paced instructional programs focused on constraint management strategies. The quality, originality, and elegance of…

  4. Superconducting magnets. Citations from NTIS data base

    Science.gov (United States)

    Reimherr, G. W.

    1980-10-01

    The cited reports discuss research on materials studies, theory, design and applications of superconducting magnets. Examples of applications include particle accelerators, MHD power generation, superconducting generators, nuclear fusion research devices, energy storage systems, and magnetic levitation. This updated bibliography contains 218 citations, 88 of which are new entries to the previous edition.

  5. 75 FR 47263 - Certain Hot-Rolled Flat-Rolled Carbon-Quality Steel Products From the Russian Federation; Final...

    Science.gov (United States)

    2010-08-05

    ....'' \\1\\ See Initiation of Five-Year (``Sunset'') Review, 75 FR 16437 (April 1, 2010) (Notice of..., 75 FR 16437 (2010). Section 351.218(d)(1)(i) of the Department's regulations provides domestic... International Trade Administration Certain Hot-Rolled Flat-Rolled Carbon-Quality Steel Products From the...

  6. Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways and transcription factors

    DEFF Research Database (Denmark)

    Deshmukh, Atul S; Murgia, Marta; Nagaraja, Nagarjuna;

    2015-01-01

    spectrometric (MS) workflow and a strategy to map identifications from the C2C12 cell line model to tissues, we identified a total of 10,218 proteins, including skeletal muscle specific transcription factors like myod1 and myogenin and circadian clock proteins. We obtain absolute abundances for proteins...

  7. Fighting to Educate Our Own: Teachers of Color, Relational Accountability, and the Struggle for Racial Justice

    Science.gov (United States)

    Kohli, Rita; Pizarro, Marcos

    2016-01-01

    Research demonstrates that many teachers of Color enter schools committed to challenging injustice, yet often face barriers to accomplishing this goal. This article presents emergent themes from a qualitative study with 218 self-identified, racial justice-oriented teachers of Color. Using Wilson's (2008) indigenous cultural framework of…

  8. Palmyra Atoll Site 30P-B 9/6/2006 23-24M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Palmyra Atoll, site 30P-B (05 52.907N, 162 07.218W), between 23 and 24 meters along a permanent transect.

  9. When Does the Gender Difference in Rumination Begin? Gender and Age Differences in the Use of Rumination by Adolescents

    Science.gov (United States)

    Jose, Paul E.; Brown, Isobel

    2008-01-01

    A cross-sectional non-clinical sample of 1,218 adolescents, aged 10-17 years, completed measures of stress, rumination, and depression to allow tests of the response style theory of S. Nolen-Hoeksema [J Res Adolesc 4:519-534, 1994] in adolescents, in particular whether increasing levels of stress and rumination in early adolescence are predictive…

  10. Ear Infections in Autistic and Normal Children. Brief Report.

    Science.gov (United States)

    Konstantareas, M. Mary; Homatidis, Soula

    1987-01-01

    Evaluation of the frequency of ear infections, ear tube drainage, and deafness for 51 autistic children (ages 2-18) indicated that autistic children had a greater incidence of ear infections than matched normal peers and lower functioning children had an earlier onset of ear infections than higher functioning autistic peers. (Author)

  11. Replacing 100% fruit juice with whole fruit results in a trade off of nutrient in the diets of children

    Science.gov (United States)

    The effect of replacing 100% fruit juice (FJ) with whole fruit (WF) on nutrient intake and adequacy in children's diets is unclear. The objective of this study was to model the effect of replacing FJ with WF in children's diets. Data from children 2-18 years of age (n=6,090) participating in the Na...

  12. Positron emission tomography/computed tomography for optimized colon cancer staging and follow up

    DEFF Research Database (Denmark)

    Engelmann, Bodil Elisabeth; Loft, Annika; Kjær, Andreas;

    2014-01-01

    OBJECTIVES: Optimal management of colon cancer (CC) requires detailed assessment of extent of disease. This study prospectively investigates the diagnostic accuracy of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (PET/CT) for staging and detection of recurrence...

  13. General Management Skills: Do Practitioners and Academic Faculty Agree on Their Importance?

    Science.gov (United States)

    Levenburg, Nancy M.

    1996-01-01

    Usable responses from 165 business practitioners and 218 business faculty showed significant differences on the perceived importance of general management skills, especially oral/written communication, problem solving, and teamwork. Global awareness, diversity, and project management skills received low rankings from both groups. (SK)

  14. Rose Atoll Site 8P 7/29/1999 9-10M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 8P (14 32.282S, 168 09.218W), between 9 and 10 meters along a permanent transect.

  15. 76 FR 75857 - Revisions to the California State Implementation Plan, Placer County Air Pollution Control District

    Science.gov (United States)

    2011-12-05

    ... from architectural coatings and automotive refinishing operations. We are proposing to approve two... copy location (e.g., copyrighted material, large maps), and some may not be publicly available in... INFORMATION: This proposal addresses the following local rules: PCAPCD Rule 218, Architectural Coatings...

  16. 77 FR 30996 - Taking and Importing Marine Mammals: Taking Marine Mammals Incidental to Navy's Research...

    Science.gov (United States)

    2012-05-24

    ... sonar levels and output were intermittent and could vary within the S6, S7, and S8 source parameters as... (76 FR 20257), and remain in effect through April 11, 2016. They are codified at 50 CFR part 218..., 2012, NMFS published a final rule (77 FR 4917) that allows for the issuance of multi-year LOAs, as...

  17. Young People in 1992.

    Science.gov (United States)

    Balding, John

    This document contains the results of the Health Related Behaviour Questionnaire which was administered to 20,218 students between the ages of 11 and 15 years in schools in England in 1992. The preliminary sections of the report explain the questionnaire and the survey, list the Schools Health Education Unit's databanks, describe the 1992 sample,…

  18. Do Children Understand the Basic Relationship Between Speech and Writing? The Mow-Motorcycle Test.

    Science.gov (United States)

    Rozin, Paul; And Others

    School children (N=218) who have not yet attained moderate reading fluency were tested for their awareness of a fundamental relationship between our writing system and speech: that the sounds of speech are represented in writing. Children were shown a long and short word written on a card (e.g., mow and motorcycle), and asked which word…

  19. EST Table: FS917517 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS917517 E_FL_fufe_41J10_F_0 10/09/28 61 %/218 aa ref|XP_001861467.1| pickel [Culex... quinquefasciatus] gb|EDS35652.1| pickel [Culex quinquefasciatus] 10/09/12 56 %/217 aa FBpp0229973|DvirGJ155

  20. Russki stihh : metrika, sistemõ stihhoslozhenija, prosodija (generativnõi podhod) / Mihhail Lotman

    Index Scriptorium Estoniae

    Lotman, Mihhail, 1952-

    2000-01-01

    Russian verse: its metrics, versification systems, and prosody (generative synopsis). Lk. 217-218 ; Vene värss: meetrika, värsisüsteemid ja prosoodika (generatiivne ülevaade). Lk. 241. Üldisest värsimõõduteooriast ja selle rakendamisest vene värsile

  1. How Reflective are Teachers? A Study of Kindergarten Teachers' and Special Teachers' Levels of Reflection in Day Care

    Science.gov (United States)

    Pihlaja, Paivi Marjo; Holst, Teija Kristiina

    2013-01-01

    The purpose of this study is to examine teachers' reflections of their early childhood special education work in Finnish day care. Work contents and work roles have faced many challenges in Early Childhood Special Education (ECSE), and therefore general reflection and research need to be developed. Teachers ("n"?=?218) evaluated,…

  2. A preterm lifeline

    DEFF Research Database (Denmark)

    Brødsgaard, Anne; Zimmermann, Renathe; Petersen, Mette

    2015-01-01

    PURPOSE: To present an Early Discharge Programme model for preterm infants based on family-centred care, and to describe its impact on the infants and families. DESIGN AND METHODS: Methods included longitudinal growth assessments of 218 premature infants and a qualitative synthesis of two focus...

  3. 77 FR 60107 - Marine Mammals; File No. 17298

    Science.gov (United States)

    2012-10-02

    ... National Oceanic and Atmospheric Administration RIN 0648-XC218 Marine Mammals; File No. 17298 AGENCY..., Connecticut 06355 , has applied in due form for a permit to collect, import, export, and receive marine mammal... requested under the authority of the Marine Mammal Protection Act of 1972, as amended (MMPA; 16 U.S.C....

  4. 76 FR 48146 - Marine Mammals; File No. 15330

    Science.gov (United States)

    2011-08-08

    .... SUPPLEMENTARY INFORMATION: On February 25, 2011, notice was published in the Federal Register (76 FR 10560) that... National Oceanic and Atmospheric Administration RIN 0648-XA160 Marine Mammals; File No. 15330 AGENCY... Robin Baird, PhD, Cascadia Research, 218\\1/2\\ W. 4th Avenue, Olympia, WA 98501 to take marine mammals...

  5. 76 FR 10560 - Marine Mammals; File No. 15530

    Science.gov (United States)

    2011-02-25

    ... National Oceanic and Atmospheric Administration RIN 0648-XA160 Marine Mammals; File No. 15530 AGENCY... Research, 218 W. 4th Avenue, Olympia, WA 98501, has applied in due form for a permit to take marine mammals... under the authority of the Marine Mammal Protection Act of 1972, as amended (MMPA; 16 U.S.C. 1361 et...

  6. How Should Reading Disabilities Be Operationalized? A Survey of Experts.

    Science.gov (United States)

    Speece, Deborah L.; Shekita, Lesley

    2002-01-01

    A survey of 218 learning disabilities experts found only 30 percent believed IQ-reading achievement discrepancy should be a marker of reading disability. Over two thirds selected three markers: reading achievement, phonemic awareness, and treatment validity. Over 75 percent believed exclusion criteria should remain part of the definition with…

  7. EST Table: FS830302 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS830302 E_FL_fmgV_34G24_R_0 10/09/28 84 %/218 aa gb|AAB26023.1| alkaliphilic serin...a] 10/09/10 37 %/203 aa FBpp0173021|DmojGI23804-PA 10/08/29 33 %/222 aa ZK546.15#CE36075#WBGene00006619#locu

  8. 30 CFR 250.1012 - Required payments for pipeline right-of-way holders.

    Science.gov (United States)

    2010-07-01

    ... in 30 CFR 218.54. If you fail to make a payment that is late after written notice from MMS, MMS may initiate cancellation of the right-of-use grant and easement under 30 CFR 250.1013. ... holders. 250.1012 Section 250.1012 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF...

  9. 27 CFR 24.259 - Marks.

    Science.gov (United States)

    2010-04-01

    ... marked on bulk containers of special natural wine or other wine produced under § 24.218; (4) The net... each case in lieu of the net contents of the case; and (5) Except for cases, the date of removal or... marked upon the container larger than four liters or the case or placed on a label or tag...

  10. 17 CFR 270.8f-1 - Deregistration of certain registered investment companies.

    Science.gov (United States)

    2010-04-01

    ... Commission on Form N-8F (17 CFR 274.218) if the investment company: (a) Has sold substantially all of its.... 80a-3(c)(7)) of the Act; or (d) Has become a business development company. Note to § 270.8f-1... investment company; (b) Has distributed substantially all of its assets to its shareholders and has...

  11. Positron emission tomography/computerized tomography in lung cancer

    OpenAIRE

    Sahiner, Ilgin; Vural, Gulin Ucmak

    2014-01-01

    Positron emission tomography (PET) using 2-(18F)-flouro-2-deoxy-D-glucose (FDG) has emerged as a useful tool in the clinical work-up of lung cancer. This review article provides an overview of applications of PET in diagnosis, staging, treatment response evaluation, radiotherapy planning, recurrence assessment and prognostication of lung cancer.

  12. 75 FR 60084 - Purified Carboxymethylcellulose from Mexico: Preliminary Results of the First Five-year (“Sunset...

    Science.gov (United States)

    2010-09-29

    ... Initiation of Five-year (``Sunset'') Review, 75 FR 30777 (June 2, 2010) (Notice of Initiation). The... Initiation from the domestic interested party and respondent interested party, Quimica Amtex S.A. de C.V. (Quimica Amtex), within the 30-day deadline specified in 19 CFR 351.218(d)(3)(i).\\1\\ The Department did...

  13. [Changes in ECG indicators during bicycle ergometry in patients having suffered myocardial infarction].

    Science.gov (United States)

    Kheifets, Z N

    1984-01-01

    Altogether 218 patients with a history of myocardial infarction were subjected to bicycle ergometry. The ECG recorded at the height of the exercise showed a significant increase in the heart rate and in the amplitudes of P and R waves. The diastole and electric systole shortened. As the load was raised, the rate of A-B conduction was relatively decelerated.

  14. Rose Atoll Site 8P 7/28/2004 10-11M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 8P (14 32.282S, 168 09.218W), between 10 and 11 meters along a permanent transect.

  15. Preoperative Computed Tomography Findings for Patients with Nasolacrimal Duct Obstruction or Stenosis

    Science.gov (United States)

    Choi, Seong Chan; Lee, Saem; Choi, Hye Sun; Jang, Jae Woo; Kim, Sung Joo

    2016-01-01

    Purpose To identify and analyze the role of preoperative computed tomography (CT) in patients with tearing symptoms with nasolacrimal duct obstruction (NLDO). Methods We retrospectively reviewed the medical records and CT results on 218 patients who complained of tearing symptoms with NLDO between January 2014 and December 2014. All patients were recruited from Kim's Eye Hospital's outpatient clinic and assessed by clinical history, examination, and CT to evaluate periocular pathology and nasolacrimal drainage system. Patients with abnormal findings assessed by preoperative CT were further reviewed. Results CT was performed on 218 patients (average age, 58.2 ± 11.9 years). Of these, 196 (89.9%) had endonasal dacryocystorhinostomy, 14 (6.4%) declined surgery, and 8 (3.7%) were inoperable due to abnormal CT findings. Soft tissue opacity was the most common finding which 243 cases (85.9%) of 283 obstructed nasolacrimal duct and 89 cases (81.7%) of 109 non-obstructed nasolacrimal duct showed it. Thirty-nine (17.8%) of 218 patients showed either maxillary sinusitis or ethmoidal sinusitis and 32 (14.7%) of 218 patients presented with periocular inflammation. Other abnormal CT findings included septal deviations, previous fractures, masses, and structural abnormalities of nasal cavity. Conclusions Preoperative CT imaging is useful in the assessment of both nasolacrimal drainage and nearby anatomical structures. This information will be helpful in planning surgical interventions and management of NLDO. PMID:27478350

  16. Urokinase-Type Plasminogen Activator Receptor as a Potential PET Biomarker in Glioblastoma

    DEFF Research Database (Denmark)

    Persson, Morten; Nedergaard, Mette K; Brandt-Larsen, Malene;

    2016-01-01

    an orthotopic xenograft model of glioblastoma. Tumor growth was monitored using bioluminescence imaging. Five to six weeks after inoculation, all mice were scanned with small-animal PET/CT using two new uPAR PET ligands ((64)Cu-NOTA-AE105 and (68)Ga-NOTA-AE105) and, for comparison, O-(2-(18)F...

  17. Dose painting based on tumor uptake of Cu-ATSM and FDG

    DEFF Research Database (Denmark)

    Clausen, Malene Martini; Hansen, Anders Elias; Lundemann, Michael;

    2014-01-01

    Background: Hypoxia and increased glycolytic activity of tumors are associated with poor prognosis. The of this study was to investigate differences in radiotherapy (RT) dose painting based on the uptake of 2-deoxy-2-[18 F]- fluorodeoxyglucose (FDG) and the proposed hypoxia tracer, copper(II)diac...

  18. 75 FR 32343 - Debt Collection and Administrative Offset for Monies Due the Federal Government

    Science.gov (United States)

    2010-06-08

    ..., Minerals Revenue Management, P.O. Box 25165, MS 61013B, Denver, Colorado 80225. Hand-carry comments or use... questions on procedural issues, contact Hyla Hurst, Regulatory Specialist, Minerals Revenue Management (MRM... Minerals Management Service 30 CFR Part 218 RIN 1010-AD36 Debt Collection and Administrative Offset...

  19. 30 CFR 243.201 - How will MMS determine if I am financially solvent?

    Science.gov (United States)

    2010-07-01

    ... solvent? 243.201 Section 243.201 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS REVENUE MANAGEMENT Financial... making payments found in 30 CFR 218.51. You are not required to use Electronic Funds Transfer (EFT)...

  20. Revisiting Parental Monitoring : Evidence that Parental Solicitation Can be Effective When Needed Most

    NARCIS (Netherlands)

    Laird, Robert D.; Marrero, Matthew D.; Sentse, Miranda

    2010-01-01

    Studies using valid measures of monitoring activities have not found the anticipated main effects linking greater monitoring activity with fewer behavioral problems. This study focused on two contexts in which monitoring activities may be particularly influential. Early adolescents (n = 218, M age =

  1. Information Management and Behavior Problems: Is Concealing Misbehavior Necessarily a Sign of Trouble?

    Science.gov (United States)

    Laird, Robert D.; Marrero, Matthew D.

    2010-01-01

    This study sought to determine whether adolescents' strategic management of information about their misbehavior was associated with behavior problems and whether the associations were moderated by parental trust or adolescent authority beliefs. Data were provided by 218 mother-adolescent dyads. Adolescents (49% female; M age = 12 years) reported…

  2. Analyzing Science Activities in Force and Motion Concepts: A Design of an Immersion Unit

    Science.gov (United States)

    Ayar, Mehmet C.; Aydeniz, Mehmet; Yalvac, Bugrahan

    2015-01-01

    In this paper, we analyze the science activities offered at 7th grade in the Turkish science and technology curriculum along with addressing the curriculum's original intent. We refer to several science education researchers' ideas, including Chinn & Malhotra's (Science Education, 86:175--218, 2002) theoretical framework and…

  3. Drug: D04269 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available saponifiable matter of soybean oil. map07052 Antidyslipidemic agents Therapeutic category of drugs in Japan ...[BR:br08301] 2 Agents affecting individual organs 21 Cardiovascular agents 218 Hyperlipidemia agents 2189 Others D04269 Soysterol (JAN) PubChem: 47206204 ...

  4. Drug: D04267 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available lyceride of polyene, linked to the choline ester of phosphoric acid. Therapeutic category: 2189 3919 map07052 Antidyslipidemic agents...organs 21 Cardiovascular agents 218 Hyperlipidemia agents 2189 Others D04267 Poly...enephosphatidyl choline (JAN) 3 Agents affecting metabolism 39 Other agents affecting metabolism 391 Liver disease agents

  5. Drug: D03343 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 8 (JP16); MDS (TN) Therapeutic category: 2189 ATC code: B05AA05 map07052 Antidyslipidemic agents Therapeutic... category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 21 Cardiovascular agents 218 Hyperlipidemia agents

  6. Opsoclonus-induced occipital deactivation with a region-specific distribution

    NARCIS (Netherlands)

    de Jong, BM; van Weerden, TW; Haaxma, R

    2001-01-01

    The cerebral distribution of 2-[18F]fluoro 2-deoxy-D-glucose (FDG) uptake in a patient with opsoclonus was measured by positron emission tomography (PET) and subsequently compared with the distribution in ten normal subjects. Statistical parametric mapping (SPM) revealed a decreased occipital FDG up

  7. ADAPTIVE DEVICES IN YOUNG PEOPLE WITH UPPER LIMB REDUCTION DEFICIENCIES : USE AND SATISFACTION

    NARCIS (Netherlands)

    Golea-Vasluian, Ecaterina; van Wijk, Iris; Dijkstra, Pieter U.; Reinders - Messelink, Heelen; van der Sluis, Corry K.

    2015-01-01

    Objective: To evaluate use of, satisfaction with, and social adjustment with adaptive devices compared with prostheses in young people with upper limb reduction deficiencies. Methods: Cross-sectional study of 218 young people with upper limb reduction deficiencies (age range 2-20 years) and their pa

  8. 29 CFR 502.3 - Discrimination prohibited.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Discrimination prohibited. 502.3 Section 502.3 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS ENFORCEMENT... discriminate against any person who has: (1) Filed a complaint under or related to sec. 218 of the INA or...

  9. Zooplankton standing stock assessment and fishery resources in the indian seas

    Digital Repository Service at National Institute of Oceanography (India)

    Goswami, S.C.; Sarupria, J.S.; Bhargava, R.M.S.

    .6 ml m sup(-3) (av. = 0.156 plus or minus 0.218 ml m sup(-3)) and 0.02 to 0.37 ml m sup(-3) (av. = 0.12 plus or minus 0.079 ml m sup(-3)) respectively. The general pattern of zooplankton distribution showed an increasing trend towards north...

  10. 76 FR 51381 - Supplemental Awards to Seven Unaccompanied Alien Shelter Care Providers

    Science.gov (United States)

    2011-08-18

    ... HUMAN SERVICES Office of Refugee Resettlement Supplemental Awards to Seven Unaccompanied Alien Shelter... Resettlement announces the award of single-source expansion supplement grants to seven Unaccompanied Alien... supplement grants to seven unaccompanied alien shelter care providers for a total of $5,016,218....

  11. Yeast Extract: Sucrose Ratio Effects on Egg Load, Survival, and Mortality Caused by GF-120 in Western Cherry Fruit Fly

    Science.gov (United States)

    Extrinsic sources of nitrogen are needed by tephritid fruit flies for optimal nutrition. In this study, relationships between yeast extract diets containing 0, 0.109, 0.545, 1.09, 2.18, 3.27, and 5.45% nitrogen (N) and diet intake, survival, egg production, and responses to spinosad bait in western...

  12. Evaluation of doubly labeled water for measuring energy expenditure during changing nutrition

    International Nuclear Information System (INIS)

    Change in abundance of 2H and 18O in dietary water during a doubly labeled water energy period may introduce error into the calculated carbon dioxide production rate (RCO2). To examine the accuracy of 2H2(18)O during changing nutritional regimens, we compared 2H2(18)O and periodic open-circuit respiratory gas exchange (RGE) in postsurgical infants who were changing from parenteral to alternative parenteral and/or oral nutrition. The two methods were compared before and after correction for shifts in isotopic abundance of the infant water pools during the energy-expenditure period. Baseline corrections were predicted using the difference between abundances of the initial body water and final nutrient solutions. Before isotopic correction, 2H2(18)O underestimated RCO2 in eight subjects by 11.8 +/- 20.1% (mean +/- SD). After correction, agreement between the two methods improved; the underestimate was then -8.7 +/- 12.9%. To obtain maximum precision of 2H2(18)O, subjects should be maintained on the same nutritional regimen before and during the study unless valid correction formulae are used

  13. Palmyra Atoll Site 30P-B 9/6/2006 27-28M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Onemetersquare 1 meter x 1 meter benthic substrate at Palmyra Atoll, site 30PB 05 52.907N, 162 07.218W, between 27 and 28 meters along a permanent transect.

  14. 41 CFR 102-75.725 - What does the transfer request contain?

    Science.gov (United States)

    2010-07-01

    ... DISPOSAL Surplus Real Property Disposal Property for Displaced Persons § 102-75.725 What does the transfer... property is required to house displaced persons authorized by section 218; that all other options... obtain replacement housing for displaced persons as authorized under title II of the Relocation Act;...

  15. Exploring Physical Activity by Ethnicity and Gender in College Students Using Social Cognitive Theory

    Science.gov (United States)

    Nehl, Eric J.; Blanchard, Chris M.; Kupperman, Janet; Sparling, Phillip; Rhodes, Ryan; Torabi, Mohammad R.; Courneya, Kerry S.

    2012-01-01

    Intervention;The psychological determinants of physical activity (PA) among college students may vary by ethnicity and gender, but few studies have considered these characteristics. This study tested constructs from Social Cognitive Theory (SCT) by ethnicity and gender to explain differences in PA. A total of 231 Blacks (70% female) and 218 White…

  16. AcEST: DK952173 [AcEST

    Lifescience Database Archive (English)

    Full Text Available 56 tr|Q94KH9|Q94KH9_AVIMR Aluminium induced protein OS=Avicennia ma... 218 2e-55 ... 618 S A+FPQGC+FS Sbjct: 181 KSLASFPQGCFFS 193 >tr|Q94KH9|Q94KH9_AVIMR Aluminium induced protein OS=Avicenni

  17. AcEST: DK960561 [AcEST

    Lifescience Database Archive (English)

    Full Text Available =Popul... 220 7e-56 tr|Q94KH9|Q94KH9_AVIMR Aluminium induced protein OS=Avicennia ma... 218 2e-55 tr|Q6UK15|...5 S A+FPQGC+FS+ Sbjct: 181 KSLASFPQGCFFST 194 >tr|Q94KH9|Q94KH9_AVIMR Aluminium i

  18. 77 FR 17033 - Taking and Importing Marine Mammals: Taking Marine Mammals Incidental to Navy's Training...

    Science.gov (United States)

    2012-03-23

    ... discussion of the lessons learned, and discussed how to improve the Navy's monitoring plan moving forward. If... GOMEX Range Complex were published on February 17, 2011 (76 FR 9250), and remain in effect through... Register notice and 50 CFR part 218 subpart D. On February 1, 2012, NMFS published a final rule (77 FR...

  19. Influence of aging on the quality of the skin of white women: the role of collagen Influência do envelhecimento na qualidade da pele de mulheres brancas: o papel do colágeno

    OpenAIRE

    Eloina do Rocio Valenga Baroni; Maria de Lourdes Pessole Biondo-Simões; André Auersvald; Luiz Augusto Auersvald; Mário Rodrigues Montemor Netto; Morgana Cláudia Aparecida Bergamo Ortolan; Juliana Nemetz Kohler

    2012-01-01

    PURPOSE: Evaluate the influence of aging on the quality of the skin of white women, analyzing the dermal collagen. METHODS: Pre-auricular flaps were collected for histological and morphometric analysis of 218 white women who underwent spontaneous facial aesthetic plastic surgery. Picrosirius ultrared stain was used for analysis and quantification of collagen in five age groups (

  20. African-American Parents' Racial and Ethnic Socialization and Adolescent Academic Grades: Teasing out the Role of Gender

    Science.gov (United States)

    Brown, Tiffany L.; Linver, Miriam R.; Evans, Melanie; DeGennaro, Donna

    2009-01-01

    This study examined the relationship of racial and ethnic socialization and academic achievement in a sample of 218 African American adolescents (grades 9-12; 52% girls) attending a public high school in the northeastern United States. Researchers were particularly interested in whether adolescent gender moderated the relationship between racial…

  1. Rose Atoll Site 8P 7/29/1999 8-9M

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — One-meter-square (1 meter x 1 meter) benthic substrate at Rose Atoll, site 8P (14 32.282S, 168 09.218W), between 8 and 9 meters along a permanent transect.

  2. 7 CFR 2.51 - Deputy Under Secretary for Food Safety.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Deputy Under Secretary for Food Safety. 2.51 Section 2... Safety § 2.51 Deputy Under Secretary for Food Safety. Pursuant to § 2.18, and subject to policy guidance... Secretary for Food Safety to the Deputy Under Secretary for Food Safety, to be exercised only during...

  3. Gclust Server: 33311 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 33311 HSA_113419846 Cluster Sequences Related Sequences(5) 218 XP_001131474.1 PREDI...CTED: hypothetical protein ; no annotation 3 1.00e-99 0.0 0.0 0.0 0.0 0.0 12.5 Show 33311 Cluster ID 33311 Sequence ID HSA_113419846

  4. Measurement of radon daughters in air samples by alpha spectroscopy

    International Nuclear Information System (INIS)

    The concentration of radon progeny in air has been determined by alpha spectrometry measurement of polonium 214 and polonium 218. A known volume of air was passed through a filter, then the alpha activity was directly measured on this filter (Author)

  5. Study on the Microwave Permittivity of Single-Walled Carbon Nanotube

    Science.gov (United States)

    Liu, Xiaolai; Zhao, Donglin

    2009-01-01

    In this article, we studied the microwave permittivity of the complex of the single-walled carbon nanotube and paraffin in 2-18GHz. In the range, the dielectric loss of single-walled carbon nanotube is higher, and the real part and the imaginary part of the dielectric constant decrease with the increase of frequency, and the dielectric constant…

  6. Fluid jet polishing of optical surfaces

    NARCIS (Netherlands)

    Fähnle, O.W.; Brug, H. van; Frankena, H.J.

    1998-01-01

    We present a new finishing process that is capable of locally shaping and polishing optical surfaces of complex shapes. A fluid jet system is used to guide a premixed slurry at pressures less than 6 bars to the optical surface. We used a slurry comprising water and 10% #800 SiC abrasives (21.8 μm to

  7. 75 FR 43931 - Certain Hot-Rolled Flat-Rolled Carbon-Quality Steel Products from Brazil: Preliminary Results of...

    Science.gov (United States)

    2010-07-27

    ...-Year (``Sunset'') Review, 75 FR 16437 (April 1, 2010). Within the deadline specified in 19 CFR 351.218... defined in the HTSUS. Tool steels, as defined in the HTSUS. Silico-manganese (as defined in the HTSUS) or..., in coils, with an inclusion rating of 1.0 maximum per ASTM E 45, Method A, with excellent...

  8. QUATERNARY GEOLOGY & GEOMORPHOLOGY

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>20040655 Du Yun (Institute of Geodesy & Geophysics, Chinese Academy of Sciences, Wuhan, Hubei); Yin Hongfu Study on Historical Environment, in Dongting Lake Area, Hunan Province, China (Earth Science-Journal of China University of Geo-sciences, ISSN1671-2383, CN42-1233/P, 28(2), 2003, p. 214-218, 1 illus. , 12 refs. , with English abstract)

  9. 42 CFR 57.205 - Health professions student loan funds.

    Science.gov (United States)

    2010-10-01

    ... FOR CONSTRUCTION OF TEACHING FACILITIES, EDUCATIONAL IMPROVEMENTS, SCHOLARSHIPS AND STUDENT LOANS... will be accounted for separately from other funds, providing a clear audit trail for all transactions... noncompliance provisions of § 57.218 and the Department's Claims Collections regulations (45 CFR part 30),...

  10. 75 FR 64315 - National Institute of Neurological Disorders and Stroke; Notice of Closed Meeting

    Science.gov (United States)

    2010-10-19

    ... grant applications. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard..., Neuroscience Center, 6001 Executive Blvd., Room 3208, MSC 9529, Bethesda, MD 20892-9529. 301-496-0635. Rc218u... Neurological Disorders; 93.854, Biological Basis Research in the Neurosciences, National Institutes of...

  11. Validation study suggested no differential misclassification of self-reported mammography history in BRCA1/2 mutation carriers

    NARCIS (Netherlands)

    Pijpe, Anouk; Mulder, Renee L.; Manders, Peggy; van Leeuwen, Flora E.; Rookus, Matti A.

    2011-01-01

    Objectives: We assessed accuracy of self-reported lifetime mammography history by BRCA1/2 mutation carriers with and without breast cancer. Study Design and Setting: Within the framework of the HEBON study (The Netherlands Collaborative Group on Hereditary Breast Cancer), 218 Dutch BRCA1/2 mutation

  12. Looking at Algorithm Visualization through the Eyes of Pre-Service ICT Teachers

    Science.gov (United States)

    Saltan, Fatih

    2016-01-01

    The study investigated pre-service ICT teachers' perceptions of algorithm visualization (AV) with regard to appropriateness of teaching levels and contribution to learning and motivation. In order to achieve this aim, a qualitative case study was carried out. The participants consisted of 218 pre-service ICT teachers from four different…

  13. Critical review of analytical techniques for safeguarding the thorium-uranium fuel cycle

    Energy Technology Data Exchange (ETDEWEB)

    Hakkila, E.A.

    1978-10-01

    Conventional analytical methods applicable to the determination of thorium, uranium, and plutonium in feed, product, and waste streams from reprocessing thorium-based nuclear reactor fuels are reviewed. Separations methods of interest for these analyses are discussed. Recommendations concerning the applicability of various techniques to reprocessing samples are included. 15 tables, 218 references.

  14. Trajectories of Career Aspirations through Adolescence and Young Adulthood: Early Math Achievement as a Critical Filter

    Science.gov (United States)

    Shapka, Jennifer D.; Domene, Jose F.; Keating, Daniel P.

    2006-01-01

    Growth curve modelling was used to trace the trajectory of the prestige dimension of career aspirations from Grade 9 through to 3 years after high school, as a function of gender and early high school math achievement. The sample consisted of 218 university-bound adolescents (129 female, 89 male). Initial aspiration levels, the slope, and the…

  15. Consumption of 100% fruit juice is associated with better nutrient intake and diet quality but not with weight status in children: NHANES 2007-2010

    Science.gov (United States)

    This study examined the impact of various levels of 100% fruit juice (FJ) consumption on intake of nutrients, diet quality, and weight in children using the more recent national data. We conducted a cross-sectional study examining the data from children 2-18 years of age (n=6,090). Intake of nutrien...

  16. 75 FR 60748 - Environmental Impacts Statements; Notice of Availability

    Science.gov (United States)

    2010-10-01

    ... the Federal Register. EIS No. 20100386, Draft EIS, BLM, UT, Uinta Basin Natural Gas Development Project, To Develop Oil and Natural Gas Resources within the Monument Butte-Red Wash and West Tavaputs... Period Ends: 10/27/2010, Contact: Peter Taylor, 218-626-4368. Revision to FR Notice published...

  17. EST Table: DC547464 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DC547464 E_FL_phe-_10J17_F_0 10/09/28 81 %/218 aa ref|NP_001040506.1| bmp-2 protein... [Bombyx mori] gb|ABF60228.1| bmp-2 [Bombyx mori] 10/09/02 low homology 10/08/28 n.h 10/09/10 42 %/150 aa AG

  18. The Ambivalent Impact of Coffee Certification on Farmers' Welfare

    NARCIS (Netherlands)

    Rijsbergen, van Bart; Elbers, Willem; Ruben, Ruerd; Njuguna, Samuel N.

    2016-01-01

    Certification is promoted to improve rural welfare through better market access and improved agricultural practices. We compare net effects of Fairtrade- and Utz-Certified coffee production in Central Kenya, using a matched panel from 218 farm-households that belong to three cooperatives and were

  19. 77 FR 26358 - Petition for Waiver of Compliance

    Science.gov (United States)

    2012-05-03

    ... Devices. A waiver is requested exempting onboard I-ETMS equipment from the requirements of Sections 218.51... in ] installing, removing, turning on, and turning off the onboard equipment. Section 229.7..., turning on, and turning off the onboard equipment. Whether I-ETMS equipment on board a locomotive...

  20. Influencing Practices through Videotape. A Systematic Evaluation of Communications Technology.

    Science.gov (United States)

    Decker, Daniel J.; Merrill, William G.

    1990-01-01

    Effectiveness of a videotape on milking procedures was evaluated by showing it to 218 dairy farmers, with previewing evaluation, 2 viewings with discussion between, and postviewing evaluation. Tape quality and information content were rated highly, but an immediate second viewing was considered less effective than providing tapes for subsequent…