WorldWideScience

Sample records for astatine 217

  1. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production.

  2. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  3. Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Jakobsson, U., E-mail: ulrjak@kth.se; Cederwall, B. [KTH, The Division of Nuclear Physics, AlbaNova University Center, SE-10691 Stockholm (Sweden); Uusitalo, J.; Auranen, K.; Badran, H.; Cox, D. M.; Grahn, T.; Greenlees, P. T.; Julin, R.; Juutinen, S.; Herzáň, A.; Konki, J.; Leino, M.; Mallaburn, M.; Pakarinen, J.; Papadakis, P.; Partanen, J.; Rahkila, P.; Sandzelius, M.; Sarén, J. [University of Jyvaskyla, Department of Physics, P.O. Box 35, FI-40014 University of Jyvaskyla (Finland); and others

    2015-10-15

    Low-lying states in neutron-deficient astatine and francium nuclei have been studied by means of in-beam and delayed spectroscopy. The 13/2{sup +} state has been observed in francium nuclei with a similar down-sloping trend as in neighbouring astatine and bismuth isotopes, as a function of decreasing neutron number. A systematic trend can also now be seen for the 1/2{sup +} state both in astatine and francium nuclei, where the level energy decreases steeply as a function of neutron number when moving further away from the neutron shell closure. This trend is very similar between astatine nuclei and their francium isotones. Moreover, shape coexistence has been observed between the 13/2{sup +} state and the spherical 9/2{sup −} ground state in {sup 203}Fr and {sup 205}Fr.

  4. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom

    2015-01-01

    and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting......To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...

  5. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    NARCIS (Netherlands)

    Rothe, S.; Andreyev, A. N.; Antalic, S.; Borschevsky, A.; Capponi, L.; Cocolios, T. E.; De Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.; Kaldor, U.; Kudryavtsev, Yuri; Koester, U.; Lane, J. F. W.; Lassen, J.; Liberati, V.; Lynch, K. M.; Marsh, B. A.; Nishio, K.; Pauwels, D.; Pershina, V.; Popescu, L.; Procter, T. J.; Radulov, D.; Raeder, S.; Rajabali, M. M.; Rapisarda, E.; Rossel, R. E.; Sandhu, K.; Seliverstov, M. D.; Sjoedin, A. M.; Van den Bergh, P.; Van Duppen, P.; Venhart, M.; Wakabayashi, Y.; Wendt, K. D. A.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviou

  6. 14 CFR 217.7 - Certification.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Certification. 217.7 Section 217.7 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC... NONSCHEDULED SERVICES § 217.7 Certification. The certification for BTS Form 41 Schedule T-100(f) shall...

  7. 49 CFR 238.217 - Side structure.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Side structure. 238.217 Section 238.217 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Equipment § 238.217 Side structure. Each passenger car shall comply with the following: (a) Side posts...

  8. 47 CFR 87.217 - Frequencies.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Frequencies. 87.217 Section 87.217... Aeronautical Advisory Stations (Unicoms) § 87.217 Frequencies. (a) Only one unicom frequency will be assigned at any one airport. Applicants must request a particular frequency, which will be taken...

  9. 7 CFR 1280.217 - Lamb purchases.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Lamb purchases. 1280.217 Section 1280.217 Agriculture... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE LAMB PROMOTION, RESEARCH, AND INFORMATION ORDER Lamb Promotion, Research, and Information Order Assessments § 1280.217 Lamb purchases....

  10. 33 CFR 136.217 - Compensation allowable.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Compensation allowable. 136.217 Section 136.217 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... PROCEDURES; DESIGNATION OF SOURCE; AND ADVERTISEMENT Procedures for Particular Claims § 136.217...

  11. 22 CFR 217.4 - Discrimination prohibited.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discrimination prohibited. 217.4 Section 217.4... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE General Provisions § 217.4 Discrimination... participation in, be denied the benefits of, or otherwise be subjected to discrimination under any program...

  12. 46 CFR 169.217 - Posting.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Posting. 169.217 Section 169.217 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.217 Posting. The certificate of inspection must be framed...

  13. 48 CFR 252.217-7010 - Performance.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Performance. 252.217-7010... Clauses 252.217-7010 Performance. As prescribed in 217.7104(a), use the following clause: Performance (JUL..., scrap or other ship's material of the Government resulting from performance of the work as items...

  14. 22 CFR 217.23 - New construction.

    Science.gov (United States)

    2010-04-01

    ... Uniform Federal Accessibility Standards (USAF) (appendix A to 41 CFR subpart 101-19.6) shall be deemed to... 22 Foreign Relations 1 2010-04-01 2010-04-01 false New construction. 217.23 Section 217.23 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Accessibility § 217.23 New construction. (a) Design...

  15. 36 CFR 21.7 - Health examinations.

    Science.gov (United States)

    2010-07-01

    ... Section 21.7 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR HOT SPRINGS NATIONAL PARK; BATHHOUSE REGULATIONS § 21.7 Health examinations. No employee who comes in direct... Reference: For a list of communicable diseases included in the regulations of the United States...

  16. 43 CFR 17.217 - Existing facilities.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Existing facilities. 17.217 Section 17.217... facilities. (a) Accessibility. A recipient shall operate each program or activity so that when each part is... not require a recipient to make each of its existing facilities or every part of a facility...

  17. 27 CFR 24.217 - Vinegar stock.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Vinegar stock. 24.217... OF THE TREASURY LIQUORS WINE Production of Other Than Standard Wine § 24.217 Vinegar stock. Vinegar... commercial standards for the production of vinegar. Vinegar stock may be made only by the addition of...

  18. 14 CFR 145.217 - Contract maintenance.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Contract maintenance. 145.217 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.217 Contract maintenance. (a) A certificated repair station may contract a maintenance function pertaining to an article to...

  19. 48 CFR 217.7003 - Purchase request.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Purchase request. 217.7003... Property 217.7003 Purchase request. Ensure that the requiring activity provides all of the following in support of the purchase request— (a) A certification that the property is eligible for exchange...

  20. 22 CFR 217.21 - Discrimination prohibited.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discrimination prohibited. 217.21 Section 217... Discrimination prohibited. No qualified handicapped person shall, because a recipient's facilities within the... excluded from participation in, or otherwise be subjected to discrimination under any program or...

  1. 22 CFR 217.11 - Discrimination prohibited.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discrimination prohibited. 217.11 Section 217... Discrimination prohibited. (a) General. (1) No qualified handicapped person shall, on the basis of handicap, be subjected to discrimination in employment under any program or activity to which this part applies. (2)...

  2. 40 CFR 86.217-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false 86.217-94 Section 86.217-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty...

  3. 48 CFR 1252.217-72 - Performance.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Performance. 1252.217-72... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-72 Performance. As prescribed at (TAR) 48 CFR 1217.7001(b) and (c), insert the following clause: Performance (OCT 1994) (a)...

  4. 48 CFR 252.217-7004 - Job orders and compensation.

    Science.gov (United States)

    2010-10-01

    ... compensation. 252.217-7004 Section 252.217-7004 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.217-7004 Job orders and compensation. As prescribed in 217.7104(a), use the following clause: JOB ORDERS AND COMPENSATION (MAY 2006) (a) The Contracting Officer shall...

  5. Laser photodetachment of radioactive ions: towards the determination of the electronegativity of astatine

    CERN Multimedia

    Rothe, Sebastian; Welander, Jakob Emanuel; Chrysalidis, Katerina; Day Goodacre, Thomas; Fedosseev, Valentine; Fiotakis, Spyridon; Forstner, Oliver; Heinke, Reinhard Matthias; Johnston, Karl; Kron, Tobias; Koester, Ulli; Liu, Yuan; Marsh, Bruce; Ringvall Moberg, Annie; Rossel, Ralf Erik; Seiffert, Christoph; Studer, Dominik; Wendt, Klaus; Hanstorp, Dag

    2017-01-01

    Negatively charged ions are mainly stabilized through the electron correlation effect. A measure of the stability of a negative ion is the electron affinity, which the energy gain by attaching an electron to a neutral atom. This fundamental quantity is, due to the almost general lack of bound excited states, the only atomic property that can be determined with high accuracy for negative ions. We will present the results of the first laser photodetachment studies of radioactive negative ions at CERN-ISOLDE. The photodetachment threshold for the radiogenic iodine isotope 128I was measured successfully, demonstrating the performance of the upgraded GANDALPH experimental beam line. The first detection of photo-detached astatine atoms marks a milestone towards the determination of the EA of this radioactive element.

  6. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron affinity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photo-detachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral line width of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in off-line tests by the clear observation of the photo-detachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148.

  7. Analysis list: Zfp217 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Zfp217 Pluripotent stem cell + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Zfp...217.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Zfp217.5.tsv http://dbarchive.biosc...iencedbc.jp/kyushu-u/mm9/target/Zfp217.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Zfp217.Plu

  8. 48 CFR 252.217-7015 - Safety and health.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Safety and health. 252.217... Clauses 252.217-7015 Safety and health. As prescribed in 217.7104(a), use the following clause: Safety and Health (DEC 1991) Nothing contained in the Master Agreement or any job order shall relieve the...

  9. 12 CFR 741.217 - Truth in savings.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Truth in savings. 741.217 Section 741.217 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS REQUIREMENTS FOR... Also Apply to Federally Insured State-Chartered Credit Unions § 741.217 Truth in savings. Any...

  10. Ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and ionic radii of element Uus (Z = 117) and astatine.

    Science.gov (United States)

    Chang, Zhiwei; Li, Jiguang; Dong, Chenzhong

    2010-12-30

    Multiconfiguration Dirac-Fock (MCDF) method was employed to calculate the first five ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and radii for the element Uus and its homologue At. Main valence correlation effects were taken into account. The Breit interaction and QED effects were also estimated. The uncertainties of calculated IPs, EAs, and IR for Uus and At were reduced through an extrapolation procedure. The good consistency with available experimental and other theoretical values demonstrates the validity of the present results. These theoretical data therefore can be used to predict some unknown physicochemical properties of element Uus, Astatine, and their compounds.

  11. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  12. 20 CFR 217.10 - Application filed after death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Application filed after death. 217.10 Section... APPLICATION FOR ANNUITY OR LUMP SUM Applications § 217.10 Application filed after death. (a) A survivor... expenses dies before applying for the lump-sum death payment under part 234 of this chapter....

  13. 49 CFR 173.217 - Carbon dioxide, solid (dry ice).

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Carbon dioxide, solid (dry ice). 173.217 Section... Class 7 § 173.217 Carbon dioxide, solid (dry ice). (a) Carbon dioxide, solid (dry ice), when offered for... permit the release of carbon dioxide gas to prevent a buildup of pressure that could rupture...

  14. 34 CFR 668.217 - Default prevention plans.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Default prevention plans. 668.217 Section 668.217... Default prevention plans. (a) First year. (1) If your cohort default rate is equal to or greater than 30 percent you must establish a default prevention task force that prepares a plan to— (i) Identify...

  15. 30 CFR 217.51 - Lease account reconciliation.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Lease account reconciliation. 217.51 Section... MANAGEMENT AUDITS AND INSPECTIONS Oil and Gas, General § 217.51 Lease account reconciliation. Specific lease account reconciliations shall be performed with priority being given to reconciling those lease...

  16. 30 CFR 217.301 - Lease account reconciliations.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Lease account reconciliations. 217.301 Section... MANAGEMENT AUDITS AND INSPECTIONS Geothermal Resources § 217.301 Lease account reconciliations. Specific lease account reconciliations will be performed with priority being given to reconciling those...

  17. 14 CFR 217.4 - Data collected (service classes).

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Data collected (service classes). 217.4 Section 217.4 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS REPORTING TRAFFIC STATISTICS BY FOREIGN AIR CARRIERS IN CIVILIAN SCHEDULED, CHARTER, AND NONSCHEDULED SERVICES §...

  18. 25 CFR 217.6 - Method of casting votes.

    Science.gov (United States)

    2010-04-01

    ... the status quo. At the time they notify the superintendent of the votes cast on an issue, each joint... 25 Indians 1 2010-04-01 2010-04-01 false Method of casting votes. 217.6 Section 217.6 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS MANAGEMENT OF TRIBAL ASSETS...

  19. 5 CFR 532.217 - Appropriated fund survey jobs.

    Science.gov (United States)

    2010-01-01

    ... Section 532.217 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PREVAILING RATE SYSTEMS Prevailing Rate Determinations § 532.217 Appropriated fund survey jobs. (a) A lead... Material Handler 2 Maintenance Laborer 3 Packer 4 Warehouse Worker 5 Forklift Operator 5 Material...

  20. 49 CFR 1544.217 - Law enforcement personnel.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Law enforcement personnel. 1544.217 Section 1544... AND COMMERCIAL OPERATORS Operations § 1544.217 Law enforcement personnel. (a) The following applies to... for law enforcement personnel meeting the qualifications and standards specified in §§ 1542.215...

  1. 48 CFR 217.171 - Multiyear contracts for services.

    Science.gov (United States)

    2010-10-01

    ... instructor skills (e.g., training for pilots and aircrew members or foreign language training). (iv) Base... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Multiyear contracts for services. 217.171 Section 217.171 Federal Acquisition Regulations System DEFENSE ACQUISITION...

  2. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  3. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  4. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  5. 12 CFR 217.1 - Authority, purpose, and scope.

    Science.gov (United States)

    2010-01-01

    ...(t) of the Board's Regulation D—Reserve Requirements of Depository Institutions (12 CFR 20.4). ... 217.1 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM... Reserve Act (12 U.S.C. 371a, 461, 505), section 7 of the International Banking Act of 1978 (12 U.S.C....

  6. 49 CFR 1542.217 - Law enforcement personnel.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Law enforcement personnel. 1542.217 Section 1542... Law enforcement personnel. (a) Each airport operator must ensure that law enforcement personnel used... the criminal laws of the State and local jurisdictions in which the airport is located— (1) A...

  7. 20 CFR 702.217 - Penalty for false statement, misrepresentation.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Penalty for false statement... PROCEDURE Claims Procedures Notice § 702.217 Penalty for false statement, misrepresentation. (a) Any..., or his dependents pursuant to section 9, 33 U.S.C. 909, if the injury results in death, shall...

  8. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  9. The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression

    Science.gov (United States)

    Littlepage, Laurie E.; Adler, Adam S.; Kouros-Mehr, Hosein; Huang, Guiqing; Chou, Jonathan; Krig, Sheryl R.; Griffith, Obi L.; Korkola, James E.; Qu, Kun; Lawson, Devon A.; Xue, Qing; Sternlicht, Mark D.; Dijkgraaf, Gerrit J. P.; Yaswen, Paul; Rugo, Hope S.; Sweeney, Colleen A.; Collins, Colin C.; Gray, Joe W.; Chang, Howard Y.; Werb, Zena

    2013-01-01

    The transcription factor ZNF217 is a candidate oncogene in the amplicon on chromosome 20q13 that occurs in 20% to 30% of primary human breast cancers and that correlates with poor prognosis. We show that Znf217 overexpression drives aberrant differentiation and signaling events, promotes increased self-renewal capacity, mesenchymal marker expression, motility, and metastasis, and represses an adult tissue stem cell gene signature downregulated in cancers. By in silico screening, we identified candidate therapeutics that at low concentrations inhibit growth of cancer cells expressing high ZNF217. We show that the nucleoside analogue triciribine inhibits ZNF217-induced tumor growth and chemotherapy resistance and inhibits signaling events [e.g., phospho-AKT, phospho-mitogen-activated protein kinase (MAPK)] in vivo. Our data suggest that ZNF217 is a biomarker of poor prognosis and a therapeutic target in patients with breast cancer and that triciribine may be part of a personalized treatment strategy in patients overexpressing ZNF217. Because ZNF217 is amplified in numerous cancers, these results have implications for other cancers. SIGNIFICANCE This study finds that ZNF217 is a poor prognostic indicator and therapeutic target in patients with breast cancer and may be a strong biomarker of triciribine treatment efficacy in patients. Because previous clinical trials for triciribine did not include biomarkers of treatment efficacy, this study provides a rationale for revisiting triciribine in the clinical setting as a therapy for patients with breast cancer who overexpress ZNF217. PMID:22728437

  10. Proton Polarimeter Calibration between 82 and 217 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Glister, J; Lee, B; Beck, A; Brash, E; Camsonne, A; Choi, S; Dumas, J; Feuerbach, R; Gilman, R; Higinbotham, D W; Jiang, X; Jones, M K; May-Tal Beck, S; McCullough, E; Paolone, M; Piasetzky, E; Roche, J; Rousseau, Y; Sarty, A J; Sawatzky, B; Strauch, S

    2009-07-01

    The proton analyzing power in carbon has been measured for energies of 82 to 217 MeV and proton scattering angles of 5 to 41 degrees. The measurements were carried out using polarized protons from the elastic scattering H(pol. e, pol. p) reaction and the Focal Plane Polarimeter (FPP) in Hall A of Jefferson Lab. A new parameterization of the FPP p-C analyzing power was fit to the data, which is in good agreement with previous parameterizations and provides an extension to lower energies and larger angles. The main conclusions are that all polarimeters to date give consistent measurements of the carbon analyzing power, independently of the details of their construction and that measuring on a larger angular range significantly improves the polarimeter figure of merit at low energies.

  11. 48 CFR 217.175 - Multiyear contracts for electricity from renewable energy sources.

    Science.gov (United States)

    2010-10-01

    ... electricity from renewable energy sources. 217.175 Section 217.175 Federal Acquisition Regulations System... renewable energy sources. (a) The head of the contracting activity may enter into a contract for a period not to exceed 10 years for the purchase of electricity from sources of renewable energy, as that...

  12. 36 CFR 223.217 - Authority to dispose of special forest products.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Authority to dispose of special forest products. 223.217 Section 223.217 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER Special Forest Products §...

  13. 20 CFR 217.7 - Claim filed with the Social Security Administration.

    Science.gov (United States)

    2010-04-01

    ... Administration. (a) Claim is for life benefits. An application for life benefits under title II of the Social... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Claim filed with the Social Security Administration. 217.7 Section 217.7 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE...

  14. 42 CFR 93.217 - Office of Research Integrity or ORI.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Office of Research Integrity or ORI. 93.217 Section 93.217 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH...

  15. 9 CFR 93.217 - Import permit and declaration for poultry.

    Science.gov (United States)

    2010-01-01

    ... poultry. 93.217 Section 93.217 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND POULTRY...

  16. 49 CFR 40.217 - Where is other information on the role of STTs and BATs found in this regulation?

    Science.gov (United States)

    2010-10-01

    ... BATs found in this regulation? 40.217 Section 40.217 Transportation Office of the Secretary of... Personnel § 40.217 Where is other information on the role of STTs and BATs found in this regulation? You can find other information on the role and functions of STTs and BATs in the following sections of...

  17. Mir-217/Sirt1 pathway and diabetic nephropathy%Mir-217/Sirt1通路与糖尿病肾病

    Institute of Scientific and Technical Information of China (English)

    邵滢; 王秋月

    2015-01-01

    Mir-217 is an important member of the miRNAs family overexpressed in high glucose cultured glomerular mesangial cells.Sirt1 is an NAD (+)-dependent deacetylase,which has obtained great focus on the research of aging.Recent researches reported that Sirt1 has protective functions in diabetic nephropathy such as anti-inflammation,anti-oxidance and anti-fibrosis.In a variety of pathological conditions,mir-217 directly acts on the 3 ' translation section of Sirt1 mRNA,and inhibits expression of Sirt1 protein.Thus,mir-217/Sirt1 pathway may play a key role in the occurrence and development of diabetic nephropathy.%Mir-217是miRNAs家族的重要成员,在高糖培养的肾小球系膜细胞中表达量升高.Sirt1是一个NAD+调节的脱乙酰酶,既往在衰老性疾病中研究较多,近期发现其在糖尿病肾病中起到抗炎、抗氧化、抗纤维化等保护作用.研究指出,在多种病理条件下mir-217通过直接作用于Sirt1mRNA的3'非翻译区,显著抑制Sirt1蛋白表达,因此mir-217/Sirt1通路可能在糖尿病肾病的发生、发展中起关键作用.

  18. An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211

    Energy Technology Data Exchange (ETDEWEB)

    O’Hara, Matthew J.; Krzysko, Anthony J.; Niver, Cynthia M.; Morrison, Samuel S.; Owsley, Stanley L.; Hamlin, Donald K.; Dorman, Eric F.; Scott Wilbur, D.

    2017-04-01

    Astatine-211 (211At) is a promising cyclotron-produced radionuclide being investigated for use in targeted alpha therapy of blood borne and metastatic cancers, as well as treatment of tumor remnants after surgical resections. The isolation of trace quantities of 211At, produced within several grams of a Bi metal cyclotron target, involves a complex, multi-step procedure: (1) Bi metal dissolution in strong HNO3, (2) distillation of the HNO3 to yield Bi salts containing 211At, (3) dissolution of the salts in strong HCl, (4) solvent extraction of 211At from bismuth salts with diisopropyl ether (DIPE), and (5) back-extraction of 211At from DIPE into NaOH, leading to a purified 211At product. Step (1) has been addressed first to begin the process of automating the onerous 211At isolation process. A computer-controlled Bi target dissolution system has been designed. The system performs in-line dissolution of Bi metal from the target assembly using an enclosed target dissolution block, routing the resulting solubilized 211At/Bi mixture to the subsequent process step. The primary parameters involved in Bi metal solubilization (HNO3 concentration and influent flow rate) were optimized prior to evaluation of the system performance on replicate cyclotron irradiated targets. The results indicate that the system performs reproducibly, having nearly quantitative release of 211At from irradiated targets, with cumulative 211At recoveries that follow a sigmoidal function. The predictable nature of the 211At release profile allows the user to tune the system to meet target processing requirements.

  19. Time-differential observation of alpha -particle perturbed angular distribution; g-factor measurements for /sup 217/Ac/sup gs/ and /sup 217/Ac/sup m/

    CERN Document Server

    Maier, K H; Grawe, H; Kluge, H

    1981-01-01

    The g-factor measurements of the ground state and an isomeric level in /sup 217/Ac using the DPAD method with alpha -decay are described. The results of gamma -ray g-factor measurements for the isomer and a tentative decay scheme produced by alpha - gamma and gamma - gamma coincidence experiments are also presented. An analysis of the alpha - particle angular distributions suggests that nuclear deformation affects the observed anisotropy. (13 refs).

  20. 19 CFR 10.217 - Verification and justification of claim for preferential treatment.

    Science.gov (United States)

    2010-04-01

    .... Textile and Apparel Articles Under the African Growth and Opportunity Act § 10.217 Verification and... of the article in question, such as purchase orders, invoices, bills of lading and other shipping... importer came to the conclusion that the textile or apparel article qualifies for preferential...

  1. Yeast Interacting Proteins Database: YBR217W, YMR159C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YBR217W ATG12 Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated...ption Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to fo

  2. Yeast Interacting Proteins Database: YBR217W, YLR423C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YBR217W ATG12 Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated...scription Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p t

  3. 20 CFR 217.11 - “Good cause” for delay in filing application.

    Science.gov (United States)

    2010-04-01

    ... RETIREMENT ACT APPLICATION FOR ANNUITY OR LUMP SUM Applications § 217.11 “Good cause” for delay in filing application. (a) An applicant has “good cause” for a delay in the filing of an application for a lump-sum... time limit. (b) An applicant does not have good cause for a delay in filing if he or she was...

  4. 20 CFR 725.217 - Determination of dependency; surviving divorced spouse.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Determination of dependency; surviving... Benefits) § 725.217 Determination of dependency; surviving divorced spouse. An individual who is the miner's surviving divorced spouse (see § 725.216) shall be determined to have been dependent on the...

  5. Yeast Interacting Proteins Database: YHR114W, YDL217C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available y (0) YDL217C TIM22 Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopi...rey gene name TIM22 Prey description Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic

  6. CULTIVAR RELEASE-BRS 217 Flora: Early-maturing soybean cultivar

    Directory of Open Access Journals (Sweden)

    Plínio Itamar de Mello de Souza

    2008-01-01

    Full Text Available The soybean (Glycine max L. Merr. cultivar BRS 217 Flora was developed by Embrapa and released forproduction in the states of Goiás, Minas Gerais, Bahia, Mato Grosso and the Distrito Federal, Brazil. It is resistant to stemcanker, frog-eye leaf spot, bacterial pustule, and partially resistant to powdery mildew.

  7. 5 CFR 531.217 - Special conversion rules for certain non-GS employees.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Special conversion rules for certain non... SERVICE REGULATIONS PAY UNDER THE GENERAL SCHEDULE Determining Rate of Basic Pay Setting Pay When Appointment Or Position Changes § 531.217 Special conversion rules for certain non-GS employees. When...

  8. 30 CFR 250.217 - What solid and liquid wastes and discharges information and cooling water intake information must...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What solid and liquid wastes and discharges information and cooling water intake information must accompany the EP? 250.217 Section 250.217 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF...

  9. Adverse Drug Reactions in 2013:Analysis of 217 Cases%2013年217例药品不良反应报告分析

    Institute of Scientific and Technical Information of China (English)

    宋锦飞; 徐琳; 孙光春

    2014-01-01

    目的:了解复旦大学附属上海市第五人民医院(以下简称“我院”)药品不良反应( ADR)的发生情况,以促进临床合理用药。方法:回顾性调查2013年我院收集的217例ADR报告,从患者的年龄、性别、药品种类、给药途径等方面进行统计、分析。结果:217例ADR中,男女患者比例为0�7∶1�0;≥60岁患者78例(占35�94%);静脉给药147例(占67�74%),口服给药59例(占27�19%);抗感染药致ADR 119例,居首位;ADR临床表现主要为皮肤及其附件损害(80例,占36�87%)。结论:应加强医院ADR监测工作,合理、规范使用抗感染药,避免或减少严重的ADR发生。%OBJECTIVE:To investigate the characteristics of adverse drug reaction ( ADR ) in Shanghai Fifth People�s Hospital Affiliated to Fudan University ( hereinafter referred to as “our hospital“) so as to promote clinical rational use of drug. METHODS:217 ADR cases collected in our hospital during 2013 were analyzed statistically in terms of patients�age and gender, drug types and route of administration etc. RESULTS:The 217 ADR cases occurred in male/female ratio of 0�7∶ 1; 78 cases ( 35�94%) aged ≥60 years; 147 cases ( 67�74%) were induced via intravenous injection;59 cases(27�19%) were induced by oral drugs;the anti⁃infective drugs ranked the first in terms of ADR incidence; 80 cases ( 36�87%) manifested as lesions of skin and its appendants. CONCLUSIONS: It is important to strengthen ADR monitoring in hospital and achieve rational and standard use of anti⁃infective drugs so as to avoid or reduce the occurrence of severe ADR.

  10. Cytogenetic analysis of 217 couples with adverse pregnancy history%217对不良孕产史夫妇细胞遗传学分析

    Institute of Scientific and Technical Information of China (English)

    何淑贞; 蒲育栋; 曹金如; 陈美玲; 苏焕厚; 邓汉钊; 莫丽芳

    2016-01-01

    目的:探讨不良孕产史与外周血染色体核型之间的关系,为遗传咨询提供依据。方法采集2013年1月至2015年11月来我院就诊的217对不良孕产史患者的外周血,分别进行外周血淋巴细胞培养、制做玻片和G显带后核型分析。结果217对不良孕产史夫妇中共发现染色体异常的核型9例,异常染色体核型检出率为2.07%,多态性核型55例,检出率为12.67%。结论染色体异常是造成患者发生不良孕产史的主要原因之一,因此应对存在不良孕产史的夫妇常规开展细胞遗传学检查及适时的遗传咨询。%Objective To investigate the relationship between abnormal pregnancy and peripheral blood karyo-type, and provide the basis for genetic counseling. Methods The peripheral blood of 217 couples with adverse pregnan-cy history were collected in our hospital from January 2013 to November 2015. Then the peripheral blood lymphocytes were cultured, and karyotype analysis of G banding was carried out. Results Among 217 couples, 9 cases were found with abnormal karyotype (with the detection rate of 2.07%), and 55 cases were found with polymorphic karyotype (with the detection rate of 12.67%). Conclusion Chromosomal abnormality is an important reason that leads to adverse preg-nancy history. Therefore, the couples with adverse pregnancy history should receive routine prenatal cytogenetic exami-nation and consultation to prevent birth defects, and improve the quality of the birth service.

  11. The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5.

    Directory of Open Access Journals (Sweden)

    Hui Wang

    Full Text Available Gastric cancer (GC is one of the most common malignancies worldwide. Emerging evidence has shown that aberrant expression of microRNAs (miRNAs plays important roles in cancer progression. However, little is known about the potential role of miR-217 in GC. In this study, we investigated the role of miR-217 on GC cell proliferation and invasion. The expression of miR-217 was down-regulated in GC cells and human GC tissues. Enforced expression of miR-217 inhibited GC cells proliferation and invasion. Moreover, Glypican-5 (GPC5, a new ocncogene, was identified as the potential target of miR-217. In addition, overexpression of miR-217 impaired GPC5-induced promotion of proliferation and invasion in GC cells. In conclusion, these findings revealed that miR-217 functioned as a tumor suppressor and inhibited the proliferation and invasion of GC cells by targeting GPC5, which might consequently serve as a therapeutic target for GC patients.

  12. Triggered star formation at the borders of the H ii region Sh 2-217

    Science.gov (United States)

    Brand, J.; Massi, F.; Zavagno, A.; Deharveng, L.; Lefloch, B.

    2011-03-01

    Context. This paper is part of our ongoing study of star formation at the borders of Galactic H ii regions. In this paper, we report our observations and analysis of Sharpless 217 (Sh 2-217). Aims: We study the stars and gas in and around H ii regions to see if the various physical parameters derived from the data (such as column densities, masses, sizes, and timescales) are consistent with the predictions of a simple model of the collect-and-collapse mechanism. This should indicate whether stars forming in molecular gas at the borders of the H ii regions could have been triggered by the expansion of the ionized gas. Methods: We observed the emission of various molecules and transitions towards Sh 2-217, and obtained both near-infrared photometry in the H and K bands, and near-infrared images in [Fe ii] and H2 narrow-band filters of the stars in a molecular condensation at the edge of the H ii region, where an UC H ii region is also located. For the atomic and ionized hydrogen gas, we used literature data. Results: Several molecular condensations are found on the borders of Sh 2-217 and both behind and in front of the ionized emission. We find signs of star formation (an UC H ii region, outflows, and water masers). The masses of the larger molecular condensations, derived from 13CO-data, are ≳330-1100 M⊙, while smaller clumps or cores within them have up to several tens of solar masses. The morphology of the atomic and molecular gas associated with Sh 2-217, especially the condensations of molecular gas on its border, and the presence of star forming activity within them, is strongly indicative of it being the result of star formation triggered by the expansion of the ionized region, following the collect-and-collapse scenario. Application of a simple model illustrates that the present radii of both Sh 2-217 and the UC H ii region, the masses of the condensations, and the timescales needed to sweep up these amounts of gas and allow massive stars to form in them

  13. Clinical Analysis of 217 Children with Hearing Loss%217例听力损失儿童临床特点分析

    Institute of Scientific and Technical Information of China (English)

    蔡娟; 邹凌; 陶宣华; 杨馨婷

    2015-01-01

    Objective To investigate the children with hearing loss which didn’t have newborn hearing screening,and dis-cuss their found age and audiological characteristics. Methods From Oct 2009 to Sep 2013,total of 217 children have diagnosed hearing loss. General information of found age were investigated,and then made statistical analysis. Results The average found age for 43 children with bilateral moderate hearing loss was(55. 3 ± 13. 8)months,and the average found age for 52 children with bilateral severe hearing loss was(32. 0 ± 11. 4) months,the average found age for 79 children with bilateral profound hearing loss was(20.2 ±9.8)months. The average found age for 9 children with unilateral severe hearing loss was(96.1 ±7.6)months,The average found age for 34 children with unilateral profound hearing loss was ( 94. 2 ± 8. 1 ) months. Conclusion The unilateral hearing loss and as the hearing loss degree of children went milder,The found age might be later. It is necessary to popularize new-born hearing screening ,while to enhance the parents’ consciousness,thus promoting the early detection, diagnosis and interven-tion for children with hearing impairment.%目的:探讨未经过新生儿听力筛查,由于听力、语言发育落后而就诊,并诊断为听力损失的217例儿童的听力损失程度、特点及首诊年龄。方法对2009年10月至2013年9月到我院就诊的217例儿童,进行听力学诊断评估。结果217例听力损失患儿中,双耳中度43例,平均首诊发现年龄(55.3±13.8)个月,双耳重度52例,平均发现年龄(32.0±11.4)个月,双耳极重度79例,平均发现年龄(20.2±9.8)个月,单耳重度9例,平均发现年龄(96.1±7.6)个月,单耳极重度34例,平均发现年龄(94.2±8.1)个月。结论单耳听力损失及听力损失程度越轻的患儿,其发现年龄越晚。进行新生儿听力筛查能在6个月龄内早期发现听力损失,并及时康复干预

  14. Radioisotope space power generator. Annual report, July 1, 1975--September 30, 1976. [TPM-217 P-type selenides

    Energy Technology Data Exchange (ETDEWEB)

    Elsner, N.B.; Chin, J.; Staley, H.G.; Steeger, E.J.; Gantzel, P.K.

    1977-09-01

    TPM-217 P-type selenide usefulness in thermoelectric converters depends on its dimensional, electrical and thermal stability at high temperature and its compatibility with other converter component materials in a low pressure environment. Experimental efforts have been directed at determining: the vaporization behavior at 900/sup 0/C, the partial pressures of vaporizing species versus temperature, vapor suppression coatings, thermal expansion, dimensional stability, and the high temperature compatibility of TPM-217 with proposed end cap materials.

  15. Accretion-ejection connection in the young brown dwarf candidate ISO-Cha1 217

    CERN Document Server

    Whelan, E T; Bacciotti, F; Nisini, B; Bonito, R; Antoniucci, S; Stelzer, B; Biazzo, K; D'Elia, V; Ray, T P

    2014-01-01

    As the number of observed brown dwarf outflows is growing it is important to investigate how these outflows compare to the well studied jets from young stellar objects. A key point of comparison is the relationship between outflow and accretion activity and in particular the ratio between the mass outflow and accretion rates ($\\dot{M}_{out}$/$\\dot{M}_{acc}$). The brown dwarf candidate ISO-ChaI 217 was discovered by our group, as part of a spectro-astrometric study of brown dwarfs, to be driving an asymmetric outflow with the blue-shifted lobe having a position angle of $\\sim$ 20$^{\\circ}$. The aim here is to further investigate the properties of ISO-ChaI 217, the morphology and kinematics of its outflow, and to better constrain ($\\dot{M}_{out}$/$\\dot{M}_{acc}$). The outflow is spatially resolved in the $[SII]\\lambda \\lambda 6716,6731$ lines and is detected out to $\\sim$ 1\\farcs6 in the blue-shifted lobe and ~ 1" in the red-shifted lobe. The asymmetry between the two lobes is confirmed although the velocity as...

  16. Expressions and significance of ZNF217 in papillary thyroid carcinoma%锌指蛋白217在甲状腺乳头状癌组织中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    张丽婷; 吴文艺; 王朝阳; 黄种心; 朱世泽

    2013-01-01

    Objective To investigate the expression and clinical significance of zinc finger gene 217 (ZNF217) in human papillary thyroid carcinoma.Methods The expressions of ZNF217 mRNA and protein were detected by quantitative realtime PCR and Western blot in papillary thyroid carcinoma tissues (n =20) and adjacent normal tissues (n =20),and the data were analyzed.Results The expressions of ZNF217 mRNA and protein in papillary thyroid carcinoma were significantly higher than those in adjacent normal tissues (96.72 ± 44.19 vs 4.86 ±3.55,0.994 ± 0.172 vs 0.195 ± 0.061,both P<0.01),being higher in the papillary thyroid carcinoma with capsule invasion compared with that without capsule invasion (P<0.01).The expressions of ZNF217 mRNA and protein in papillary thyroid carcinoma were not related to gender,age,tumor size,TNM stage or lymph node metastasis (all P>0.05).Conclusions The overexpression of ZNF217 may be associated with the oncogenesis and progress of papillary thyroid carcinoma and capsule invasion,and thus is expected to become a new target for prevention and treatment of papillary thyroid carcinoma.%目的 探讨锌指蛋白217 (ZNF217)在人类甲状腺乳头状癌组织中的表达及其意义.方法 利用实时荧光定量PCR法和Western印迹法检测20例甲状腺乳头状癌组织及相应的20例癌旁正常组织中ZNF217的mRNA和蛋白表达水平,并进行统计学分析.结果 ZNF217 mRNA和蛋白在甲状腺乳头状癌组织中的表达显著高于癌旁正常甲状腺组织(96.72±44.19对4.86±3.55,0.994±0.172对0.195±0.061,均P<0.01),在甲状腺乳头状癌包膜侵犯组高于无包膜侵犯组(P<0.01).ZNF217 mRNA和蛋白的表达与患者的性别、年龄、肿瘤大小、TNM分期及有无淋巴结转移均无关(均P>0.05).结论 ZNF217的过表达可能与甲状腺乳头状癌的发生发展和包膜侵犯有关,有望成为甲状腺乳头状癌预防和治疗的一个新的靶点.

  17. HL-217, a new topical anti-angiogenic agent, inhibits retinal vascular leakage and pathogenic subretinal neovascularization in Vldlr{sup −/−} mice

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Junghyun; Kim, Chan-Sik; Jo, Kyuhyung [Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of); Cho, Yun-Seok; Kim, Hyun-Gyu; Lee, Geun-Hyeog [Research and Development Center, Hanlim Pharm. Co. Ltd., 1656-10, Seocho-dong, Seocho-gu, Seoul (Korea, Republic of); Lee, Yun Mi; Sohn, Eunjin [Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of); Kim, Jin Sook, E-mail: jskim@kiom.re.kr [Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of)

    2015-01-02

    Highlights: • HL-217 is a new synthetic topical anti-angiogenic agent. • HL-217 attenuated subretinal neovascularization in Vldlr{sup −/−} mice. • HL-217 blocked the binding of PDGF-BB to PDGFRβ. - Abstract: HL-217 is a new synthetic angiogenesis inhibitor. Platelet derived growth factor (PDGF) is a vasoactive factor and has been implicated in proliferative retinopathies. In this study, we examined the mechanism of action and efficacy of topical application of HL-217 on subretinal neovascularization in very low-density lipoprotein receptor knockout (Vldlr{sup −/−}) mice. In three-week-old male Vldlr{sup −/−} mice, HL-217 (1.5 or 3 mg/ml) was administered twice per day for 4 weeks by topical eye drop instillation. Neovascular areas were then measured. We used a protein array to evaluate the expression levels of angiogenic factors. The inhibitory effect of HL-217 on the PDGF-BB/PDGFRβ interaction was evaluated in vitro. The neovascular area in the Vldlr{sup −/−} mice was significantly reduced by HL-217. Additionally, HL-217 decreased the expression levels of PDGF-BB protein and VEGF mRNA. Moreover, HL-217 dose-dependently inhibited the PDGF-BB/PDGFRβ interaction (IC{sub 50} = 38.9 ± 0.7 μM). These results suggest that HL-217 is a potent inhibitor of PDGF-BB. HL-217, when applied topically, is an effective inhibitor of subretinal neovascularization due to its ability to inhibit the pro-angiogenic effects of PDGF-BB.

  18. ZNF217在宫颈上皮内瘤变及宫颈癌中的表达及意义%The expression and significance of ZNF217 in human cervical intraepithelial neoplasia and cervical carcinoma

    Institute of Scientific and Technical Information of China (English)

    郝汇平; 纪新强; 王晓红

    2014-01-01

    Objective To detect the expressions of zinc finger protein 217 ( ZNF217 ) in human normal cervical epithelium , cervical intraepithelial neoplasia ( CIN) and cervical carcinoma to investigate the roles of ZNF 217 in the carcinogenesis and development of cervical carcinoma, and to provide theoretical basis for clinical diagnosis and therapy .Methods The expressions of ZNF217 were detected by immunohistochemistry SP method in 60 patients with cervical carcinoma ( cervical carcinoma group ) , 18 cases with low grade of cervical intraepithelial neoplasia (CIN Ⅰgroup), 32 cases with high grade of cervical intraepithelial neoplasia (CIN Ⅱ-Ⅲ group) and 20 cases with normal cervical epithelium ( normal group ) .Results ZNF217 was mainly located in cervical cytoplasm .The positive-expression rate of ZNF217 was 25.0%, 33.3%, 50.0% and 81.5% in normal cervical epithelium tissues , CIN Ⅰ tissues, CIN Ⅱ-Ⅲtissues and the tissues of cervical carcinoma , respectively.There was significant difference in the positive-expression rate of ZNF217 between cervical carcinoma group and normal cervical epithelium group , between CINⅠgroup and cervical carcinoma group , between CINⅡ-Ⅲgroup and cervical carcinoma group (χ2 value was 18.755, 12.874 and 7.762, respectively, all P0.05 ).In the cervical carcinoma group , the expression of ZNF217 was correlated with histological grade and lymphatic metastasis (χ2 value was 12.851 and 6.222, respectively, both P0.05).Conclusion High expression of ZNF217 plays an important role in the carcinogenesis and development of cervical carcinoma .%目的:研究ZNF217在宫颈癌、宫颈上皮内瘤变及正常宫颈组织中的表达,探讨ZNF217在宫颈癌的发生、发展中的作用,为宫颈癌的临床诊断和治疗提供重要的理论依据。方法采用免疫组织化学SP法检测ZNF217在60例宫颈癌(宫颈癌组)、18例低度宫颈上皮内瘤变( CINⅠ组)、32例高度宫颈上皮内瘤变( CIN

  19. HL-217, a new topical anti-angiogenic agent, inhibits retinal vascular leakage and pathogenic subretinal neovascularization in Vldlr⁻/⁻ mice.

    Science.gov (United States)

    Kim, Junghyun; Kim, Chan-Sik; Jo, Kyuhyung; Cho, Yun-Seok; Kim, Hyun-Gyu; Lee, Geun-Hyeog; Lee, Yun Mi; Sohn, Eunjin; Kim, Jin Sook

    2015-01-02

    HL-217 is a new synthetic angiogenesis inhibitor. Platelet derived growth factor (PDGF) is a vasoactive factor and has been implicated in proliferative retinopathies. In this study, we examined the mechanism of action and efficacy of topical application of HL-217 on subretinal neovascularization in very low-density lipoprotein receptor knockout (Vldlr(-/-)) mice. In three-week-old male Vldlr(-/-) mice, HL-217 (1.5 or 3mg/ml) was administered twice per day for 4 weeks by topical eye drop instillation. Neovascular areas were then measured. We used a protein array to evaluate the expression levels of angiogenic factors. The inhibitory effect of HL-217 on the PDGF-BB/PDGFRβ interaction was evaluated in vitro. The neovascular area in the Vldlr(-/-) mice was significantly reduced by HL-217. Additionally, HL-217 decreased the expression levels of PDGF-BB protein and VEGF mRNA. Moreover, HL-217 dose-dependently inhibited the PDGF-BB/PDGFRβ interaction (IC50=38.9 ± 0.7 μM). These results suggest that HL-217 is a potent inhibitor of PDGF-BB. HL-217, when applied topically, is an effective inhibitor of subretinal neovascularization due to its ability to inhibit the pro-angiogenic effects of PDGF-BB.

  20. The ZNF217 Breast Cancer Oncogene Amplified at 20q13: A Potential Marker for Invasiveness

    Science.gov (United States)

    2012-03-01

    samples  amplified  at  20q13. We  previously  optimized  the  nuclear specific  immunohistochemistry  (supervised by the  collaborating  pathologist Dr...correlative  significance  with  ZNF217  expression  in  collaboration   with  the  biostatistician  (see  letter  of  collaboration  with Dr. Beckett who will...procedures (buildings, clinics, etc.). Note: IRB approval applies only to UC Davis organizations. Unless a written interinstitutional agreement has

  1. MicroRNA-217 suppresses homocysteine-induced proliferation and migration of vascular smooth muscle cells via N-methyl-D-aspartic acid receptor inhibition.

    Science.gov (United States)

    Duan, Hongyan; Li, Yongqiang; Yan, Lijie; Yang, Haitao; Wu, Jintao; Qian, Peng; Li, Bing; Wang, Shanling

    2016-10-01

    Hyperhomocysteine has become a critical risk for atherosclerosis and can stimulate proliferation and migration of vascular smooth muscle cells (VSMCs). N-methyl-D-aspartic acid receptor (NMDAR) is a receptor of homocysteine and mediates the effects of homocysteine on VSMCs. Bioinformatics analysis has shown NMDAR is a potential target of microRNA-217 (miR-217), which exerts multiple functions in cancer tumorigenesis and carotid plaque progression. In this study, we sought to investigate the role of miR-217 in VSMCs phenotype transition under homocysteine exposure and elucidate its effect on atherosclerotic plaque formation. After treating with several doses of homocysteine (0-8 × 10(-4)  mol/L) for 24 hours, the expression of miR-217 in HA-VSMCs and rat aortic VSMCs was not altered. Intriguingly, the expression of NMDAR mRNA and protein was reduced by homocysteine in a dose-dependent manner. Transfection of miR-217 mimic significantly inhibited the proliferation and migration of VSMCs with homocysteine treatment, while transfection of miR-217 inhibitor promoted VSMCs migration. Moreover, miR-217 mimic down-regulated while miR-217 inhibitor up-regulated NMDAR protein expression but not NMDAR mRNA expression. Through luciferase reporter assay, we showed that miR-217 could directly bind to the 3'-UTR of NMDAR. MiR-217 mimic transfection also released the inhibition of cAMP-response element-binding protein (CREB)-PGC-1α signalling induced by homocysteine. Additionally, restoration of PGC-1α expression via AdPGC-1α infection markedly suppressed VSMCs proliferation through the degradation of NADPH oxidase (NOX1) and reduction of reactive oxygen species (ROS). Collectively, our study identified the role of miR-217 in regulating VSMCs proliferation and migration, which might serve as a target for atherosclerosis therapy.

  2. Mandibulofacial Dysostosis in a Patient with a de novo 2;17 Translocation that Disrupts the HOXD Gene Cluster

    OpenAIRE

    2007-01-01

    Treacher Collins syndrome is the prototypical mandibulofacial dysostosis syndrome, but other mandibulofacial dysostosis syndromes have been described. We report an infant with mandibulofacial dysostosis and an apparently balanced de novo 2;17 translocation. She presented with severe lower eyelid colobomas requiring skin grafting, malar and mandibular hypoplasia, bilateral microtia with external auditory canal atreasia, dysplastic ossicles, hearing loss, bilateral choanal stenosis, cleft palat...

  3. 47 CFR 95.217 - (R/C Rule 17) May I operate my R/C station transmitter by remote control?

    Science.gov (United States)

    2010-10-01

    ... transmitter by remote control? 95.217 Section 95.217 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Radio Control (R/C) Radio Service How... control? (a) You may not operate an R/C transmitter by radio remote control. (See R/C Rule 12, §...

  4. Use of a genetically enhanced, pediocin-producing starter culture, Lactococcus lactis subsp. lactis MM217, to control Listeria monocytogenes in cheddar cheese

    NARCIS (Netherlands)

    Buyong, N; Kok, J; Luchansky, JB

    1998-01-01

    Cheddar cheese was prepared with Lactococcus lactis subsp, lactis MM217, a starter culture which contains pMC117 coding for pediocin PA-1, About 75 liters of pasteurized milk (containing ca, 3.6% fat) was inoculated with strain MM217 (ca, 10(6) CFU per ml) and a mixture of three Listeria monocytogen

  5. Clinical feature analysis on 217 patients with subjective tinnitus%217例主观性耳鸣的临床特征分析

    Institute of Scientific and Technical Information of China (English)

    陈玲; 杨海弟; 区永康

    2011-01-01

    目的 研究分析耳鸣患者的临床特征及听力学特点,比较不同类型耳鸣的掩蔽试验效果,探索耳鸣的个性化治疗.方法 对我科门诊及住院的主观性耳鸣患者217例,常规病史调查,同时行纯音测听、耳声发射、耳鸣检测及掩蔽,分析耳鸣患者的临床特征,评估各类耳鸣掩蔽试验的情况.结果 耳鸣在人群高发年龄段为36~ 55岁,占24%.男女比例分别为48%及52%,耳鸣发生侧别以左侧最常见(42%),双侧耳鸣次之(30%),右侧耳鸣最少(28%).城市人口及脑力劳动者居多,分别占77%和68%.病程中以慢性耳鸣患者(病程>1年)最多(占46%).耳鸣高频及低频耳鸣患者掩蔽最为有效,有效率分别为71.6%及73.6%,而中频耳鸣掩蔽有效率仅有52.2%,夫特曼曲线类型与掩蔽试验阳性率明显相关,由Ⅰ型掩蔽阳性率为89%降至Ⅴ型掩蔽阳性率为11.7%.结论 耳鸣患者各项特征与掩蔽试验、耳鸣频率等有较大相关性,可作为耳鸣治疗效果的预测指标.Feldman曲线类型在耳鸣诊断和治疗方面有很大应用价值及指导意义,是预测耳鸣掩蔽是否有效的一个重要指标,也是选择耳鸣个体化治疗的一个重要参考依据.%Objective To analysis the clinical feature and audiology feature of patients with subjective tinnitus,compare masking,screening effectiveness of various kinds tinnitus,and search for the individual treatment ways for subjective tinnitus.Methods 217 patients in our hospistor were performed pure tone test,DPOAE,tinnitus determination,and tinnitus masking including pitch matching,intensity matching,Feldmann masking curve,and residual inhibition test with TinniTestTM.Results The prevalence rate is higher in female (52%).Tinnitts occur to the left side more common (42%),followed by bilateral ears (30%) and the right side (28%).The urban population ( 77% ) and mental worker ( 68% ) were primary in patients.The patients

  6. Factors Associated with Coronary Artery Disease in Young Population (Age≤40):Analysis with 217 Cases

    Institute of Scientific and Technical Information of China (English)

    Wei-xian Yang; Zheng Yang; Yong-jian Wu; Shu-bin Qiao; Yue-jin Yang; Ji-lin Chen

    2014-01-01

    Objective To investigate the relevant factors of coronary artery disease (CAD) in young people under 40 years of age. Methods The study population was 292 young patients accepting coronary angiography in Fuwai Hospital from July to December 2006, including 272 men and 20 women, with the mean age being 36.7±3.7 years. The diagnosis of CAD was made in the cases presenting ≥50%stenosis in coronary lumen in coronary angiography. Based on the diagnosis, 217 patients (204 men, 13 women) were assigned to CAD group, and 75 (68 men, 7 women) to non-CAD group. Clinical data and metabolic characteristics of the patients were collected and analyzed using t-test,χ2 test, and multinomial logistic regression with SPSS 8.0 software. Results Most study subjects were current smokers (209/292, 71.6%), and more than half had body mass index (BMI)>24 kg/m2 (230/292, 78.8%) and usually took high-fat diet (162/292, 55.5%). The proportion of heavy smokers (smoking history ≥10 years and ≥20 cigarettes per day) were significantly higher in the CAD group than in the non-CAD group [20.7%(45/217) vs. 9.3%(7/75), P=0.015)]. Heavy smoking [odds ratio (OR), 1.89;95%confidence interval (CI), 1.74-2.05], hypertension (OR, 1.56;95%CI, 1.48-1.65), alcohol (OR, 1.37;95%CI, 1.30-1.46), type 2 diabetes mellitus (OR, 1.37;95%CI, 1.25-1.50), high-fat diet (OR, 1.35;95% CI, 1.28-1.43), and BMI>24 kg/m2 (OR, 1.09;95% CI, 1.03-1.17) were factors related to CAD in the young patients (all P Conclusions Heavy smoking, hypertension, alcohol consumption, type 2 diabetes mellitus, high-fat diet and BMI>24 kg/m2 were significantly related to CAD in patients aged ≤ 40, with heavy smoking presenting the highest OR. Metabolic syndrome and inflammation were also more common in young CAD patients than in non-CAD patients.

  7. BXERL photo-injector based on a 217 MHz normal conducting RF gun

    Institute of Scientific and Technical Information of China (English)

    LIU Sheng-Guang; HUANG Tong-Ming; XU Jin-Qiang

    2011-01-01

    The Beijing X-ray Energy Recovery Linac(BXERL)test facility is proposed in Institute of High Physics(IHEP).In this proposal,the main linac requires the injector to provide an electron beam with 5 MeV energy and 10 mA average current.An injector based on DC gun technology is the first candidate electron source for BXERL.However,the field emission in the DC gun cavity makes it much more difficult to increase the high voltage to more than 500 kV.Another technology based on a 217 MHz normal conducting RF gun is proposed as the backup injector for this test facility.We have designed this RF gun with 2D SUPERFISH code and 3D MICROWAVE STUDIO code.In this paper,we present the optimized design of the gun cavity,the gun RF parameters and the set-up of the whole injector system.The detailed beam dynamics have been done and the simulation results show that the injector can generate electron bunches with RMS normalizedemittance 1.0 πmm.mrad,bunch length 0.77 mm,beam energy 5.0 MeV and energy spread 0.60%.

  8. Na1.67Mn2.17(MoO43

    Directory of Open Access Journals (Sweden)

    Chahira Bouzidi

    2014-04-01

    Full Text Available The title compound, disodium dimanganese(II tris[orthomolybdate(VI], was prepared by solid-state reactions. The structure can be described as being composed of Mn2Mo2O14 double-chains that are interconnected by corner-sharing with MoO4 tetrahedra, leading to a three-dimensional framework with channels propagating in [100] and [001] in which the Na+ counter-cations are located. One of these Na sites is located on an inversion centre, one is partially occupied [occupancy 0.341 (9], and one is statistically occupied by Na and Mn in a ratio of 0.829 (5:0.171 (5. Na1.67Mn2.17(MoO43 is isotypic with structures of the Ag2M2(MoO43 (M = Zn, Mg, Co, Mn family. A comparative structural description is provided between the structure of the title compound and those of related phases containing (MXO8n chains (M = Mo, Mn and X = As or M2O10 (M = Mo, Mn, Nb, V dimers.

  9. Doxylamine pharmacokinetics following single dose oral administration in children ages 2-17 years.

    Science.gov (United States)

    Balan, Guhan; Thompson, Gary A; Gibb, Roger; Li, Lijuan; Hull, David; Seeck, Molly

    2013-11-01

    To characterize doxylamine pharmacokinetics in children. This study was conducted in 41 subjects, ages 2-17 years. Doxylamine succinate doses based on age/weight ranged from 3.125 to 12.5 mg. A single oral dose was administered with 2 to 4 oz. of water or decaffeinated beverages ∼2 hours after a light breakfast. Plasma samples were obtained before and for 72 hours after dosing and analyzed for doxylamine using HPLC MS/MS. Pharmacokinetic parameters were estimated using non-compartmental methods and relationships with age were assessed using linear regression. Over the fourfold dose range, Cmax was similar while AUC increased only 60%, although not statistically significant (P-value = 0.0517). As expected due to increasing body size, CLo and Vz /F increased with age. Due to a similar increase with age for Clo and Vz /F, no age-related differences in t1/2,z were observed (∼16 hours). Allometric scaling indicated no maturation related changes in CLo ; although Vz /F remained age-dependent, the predicted range decreased ∼70%. Overall, the single doses were well tolerated. Somnolence was the most common reported AE with no apparent differences in incidence noted with age. An age/weight dosing nomogram utilizing a fourfold range of doses achieves similar Cmax , whereas AUC increases only 60%.

  10. Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis.

    Science.gov (United States)

    Pruszyński, Marek; Bilewicz, Aleksander; Zalutsky, Michael R

    2008-04-01

    The goal of this study was to evaluate a new approach that can be applied for labeling biomolecules with (211)At. Many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking different (211)At labeling strategies. The approach evaluated in this study was to attach astatide anions to soft metal cations, which are also complexed by a bifunctional ligand. Ultimately, this complex could in principle be subsequently conjugated to a biomolecule with the proper selection of ligand functionality. We report here the attachment of (211)At(-) and *I(-) (*I = (131)I or (125)I) anions to the soft metal cations Rh(III) and Ir(III), which are complexed by the 1,5,9,13-tetrathiacyclohexadecane-3,11-diol (16aneS4-diol) ligand. Radioactive *I(-) anions were used for preliminary studies directed at the optimization of reaction conditions and to provide a baseline for comparison of results with (211)At. Four complexes Rh[16aneS4-diol]*I/(211)At and Ir[16aneS4-diol]*I/(211)At were synthesized in high yield in a one-step procedure, and the products were characterized mainly by paper electrophoresis and reversed-phase HPLC. The influences of time and temperature of heating and concentrations of metal cations and sulfur ligand 16aneS4-diol, as well as pH on the reaction yields were determined. Yields of about 80% were obtained when the quantities of Rh(III) or Ir(III) cations and 16aneS4-diol ligand in the solutions were 62.5 nmol and 250 nmol, respectively, and the pH ranged 3.0-4.0. Syntheses required heating for 1-1.5 h at 75-80 degrees C. The influence of microwave heating on the time and completeness of the complexation reaction was evaluated and compared with the conventional method of heating in an oil bath. Microwave synthesis accelerates reactions significantly. With microwave heating, yields of about 75% for Rh[16aneS4-diol](131)I and Ir[16aneS4-diol](131)I complexes were obtained after only 20 min exposure of the reaction mixtures to

  11. Magnetic Microstructures of 2:17 Type Sm(Co,Fe,Cu,Zr)z Magnets Detected by Magnetic Force Microscopy

    Institute of Scientific and Technical Information of China (English)

    Xia Ailin; Guo Zhaohui; Li Wei; Han Baoshan

    2006-01-01

    The magnetic microstructures of 2:17 type Sm(Co,Fe,Cu,Zr)z magnets were detected by magnetic force microscopy.Comparing the microstructures of the specimens coated with and without Ta thin film before and after heat-treatment, it is found that: (a) as a protection layer, Ta coating layer about 20 nm thick can effectively restrain Sm volatilization under high temperature;(b) the stress built in the 2:17 type Sm-Co magnets during specimen preparation only affects some local parts of the domain structures;(c) the magnetic microstructures vary largely for specimens heat-treated at high temperature without Ta film coating due to Sm volatilization.In addition, by comparing with high coercivity Fe-Pt point tips, it is found that the Co-Cr thin-film tips are not suitable for detecting the magnetic microstructures of strong permanent magnets.

  12. A computer program to generate equations of motion matrices, L217 (EOM). Volume 1: Engineering and usage

    Science.gov (United States)

    Kroll, R. I.; Clemmons, R. E.

    1979-01-01

    The equations of motion program L217 formulates the matrix coefficients for a set of second order linear differential equations that describe the motion of an airplane relative to its level equilibrium flight condition. Aerodynamic data from FLEXSTAB or Doublet Lattice (L216) programs can be used to derive the equations for quasi-steady or full unsteady aerodynamics. The data manipulation and the matrix coefficient formulation are described.

  13. Bloodstream infection following 217 consecutive systemic-enteric drained pancreas transplants

    Directory of Open Access Journals (Sweden)

    Mark Walter

    2006-08-01

    Full Text Available Abstract Background Combined kidney pancreas transplantation (PTx evolved as excellent treatment for diabetic nephropathy. Infections remain common and serious complications. Methods 217 consecutive enteric drained PTxs performed from 1997 to 2004 were retrospectively analyzed with regard to bloodstream infection. Immunosuppression consisted of antithymocyteglobuline induction, tacrolimus, mycophenolic acid and steroids for the majority of cases. Standard perioperative antimicrobial prophylaxis consisted of pipercillin/tazobactam in combination with ciprofloxacin and fluconazole. Results One year patient, pancreas and kidney graft survival were 96.4%, 88.5% and 94.8%, surgical complication rate was 35%, rejection rate 30% and rate of infection 59%. In total 46 sepsis episodes were diagnosed in 35 patients (16% with a median onset on day 12 (range 1–45 post transplant. Sepsis source was intraabdominal infection (IAI (n = 21, a contaminated central venous line (n = 10, wound infection (n = 5, urinary tract infection (n = 2 and graft transmitted (n = 2. Nine patients (4% experienced multiple episodes of sepsis. Overall 65 pathogens (IAI sepsis 39, line sepsis 15, others 11 were isolated from blood. Gram positive cocci accounted for 50 isolates (77%: Coagulase negative staphylococci (n = 28, i.e. 43% (nine multi-resistant, Staphylococcus aureus (n = 11, i.e. 17% (four multi-resistant, enterococci (n = 9, i.e. 14% (one E. faecium. Gram negative rods were cultured in twelve cases (18%. Patients with blood borne infection had a two year pancreas graft survival of 76.5% versus 89.4% for those without sepsis (p = 0.036, patient survival was not affected. Conclusion Sepsis remains a serious complication after PTx with significantly reduced pancreas graft, but not patient survival. The most common source is IAI.

  14. Reaction natYb+48Ca->217Th+3n: auto calibration process for DSSSD detector application (particular case)

    CERN Document Server

    Tsyganov, Yu

    2015-01-01

    The Dubna Gas-Filled Recoil Separator (DGFRS) is the mostly effective setup in use for the field of synthesis of superheavy elements. Application of DSSSD detector provides more precise energy and position detection for both implanted recoils and their alpha decays. To minimize contribution of background products the method of fctive correlation is applied at the DGFRS. To apply this method a precise calibration for 48 front strips is strongly required. Method of three peaks auto calibration is proposed with a first approximation step with 9.26 MeV 217Th peaks. Examples of alpha-decay original spectra and spectra after filtration procedures are presented.

  15. The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Yu; Wong, Nicholas; Guan, Yinghui; Salamanca, Clara M.; Cheng, Jung Chien; Lee, Jonathan M.; Gray, Joe W.; Auersperg, Nelly

    2008-04-25

    Ovarian epithelial carcinomas (OEC) frequently exhibit amplifications at the 20q13 locus which is the site of several oncogenes, including the eukaryotic elongation factor EEF1A2 and the transcription factor ZNF217. We reported previously that overexpressed ZNF217 induces neoplastic characteristics in precursor cells of OEC. Unexpectedly, ZNF217, which is a transcriptional repressor, enhanced expression of eEF1A2. In this study, array comparative genomic hybridization, single nucleotide polymorphism and Affymetrix analysis of ZNF217-overexpressing cell lines confirmed consistently increased expression of eEF1A2 but not of other oncogenes, and revealed early changes in EEF1A2 gene copy numbers and increased expression at crisis during immortalization. We defined the influence of eEF1A2 overexpression on immortalized ovarian surface epithelial cells, and investigated interrelationships between effects of ZNF217 and eEF1A2 on cellular phenotypes. Lentivirally induced eEF1A2 overexpression caused delayed crisis, apoptosis resistance and increases in serum-independence, saturation densities, and anchorage independence. siRNA to eEF1A2 reversed apoptosis resistance and reduced anchorage independence in eEF1A2-overexpressing lines. Remarkably, siRNA to eEF1A2 was equally efficient in inhibiting both anchorage independence and resistance to apoptosis conferred by ZNF217 overexpression. Our data define neoplastic properties that are caused by eEF1A2 in nontumorigenic ovarian cancer precursor cells, and suggest that eEF1A2 plays a role in mediating ZNF217-induced neoplastic progression.

  16. Mandibulofacial dysostosis in a patient with a de novo 2;17 translocation that disrupts the HOXD gene cluster.

    Science.gov (United States)

    Stevenson, David A; Bleyl, Steven B; Maxwell, Teresa; Brothman, Arthur R; South, Sarah T

    2007-05-15

    Treacher Collins syndrome (TCS) is the prototypical mandibulofacial dysostosis syndrome, but other mandibulofacial dysostosis syndromes have been described. We report an infant with mandibulofacial dysostosis and an apparently balanced de novo 2;17 translocation. She presented with severe lower eyelid colobomas requiring skin grafting, malar and mandibular hypoplasia, bilateral microtia with external auditory canal atreasia, dysplastic ossicles, hearing loss, bilateral choanal stenosis, cleft palate without cleft lip, several oral frenula of the upper lip/gum, and micrognathia requiring tracheostomy. Her limbs were normal. Chromosome analysis at the 600-band level showed a 46,XX,t(2;17)(q24.3;q23) karyotype. Sequencing of the entire TCOF1 coding region did not show evidence of a sequence variation. High-resolution genomic microarray analysis did not identify a cryptic imbalance. FISH mapping refined the breakpoints to 2q31.1 and 17q24.3-25.1 and showed the 2q31.1 breakpoint likely affects the HOXD gene cluster. Several atypical findings and lack of an identifiable TCOF1 mutation suggest that this child has a provisionally unique mandibulofacial dysostosis syndrome. The apparently balanced de novo translocation provides candidate loci for atypical and TCOF1 mutation negative cases of TCS. Based on the agreement of our findings with one previous case of mandibulofacial dysostosis with a 2q31.1 transocation, we hypothesize that misexpression of genes in the HOXD gene cluster produced the described phenotype in this patient.

  17. 结节性甲状腺肿外科治疗217例分析

    Institute of Scientific and Technical Information of China (English)

    庞辉

    2010-01-01

    目的 探讨结节性甲状腺肿外科治疗的时机、方法和效果.方法 回顾分析217例结节性甲状腺肿手术病人临床资料.结果 217例全部手术治疗,单纯手术治愈170例(78.3%),手术+替代治疗治愈38例(17.5%),复发9例(4.2%),总治愈率95.8%.结论 结节性甲状腺肿外科治疗效果应以提高手术技巧为主,在完全切除结节前提下,尽可能保留正常腺体,合理替代治疗术后甲状腺功能低下.

  18. Magnetic domain structures of precipitation-hardened SmCo 2:17-type sintered magnets: Heat treatment effect

    Institute of Scientific and Technical Information of China (English)

    Li Xiu-Mei; Fang Yi-Kun; Guo Zhao-Hui; Liu Tao; Guo Yong-Quan; Li Wei; Han Bao-Shan

    2008-01-01

    The typical magnetic domains of Sm(CobalFe0.25Cu0.07Zr0.02)7.4 magnets quenched through various heat-treatment steps have been revealed by using magnetic force microscopy (MFM). For the specimens in which the nominal c-axis is perpendicular to the imaging plane, the domain configurations change from plate-like for the as-sintered mag-net to corrugation and spike-like for the homogenized one, and then to a coarse and finally to a finer domain structure when isothermally aged at 830℃ and then annealed at 400℃. However, only plate-like domains can be detected on the surfaces with the nominal c-axis parallel to the imaging plane. The finer domain (so-called interaction domain) is a characteristic magnetic domain pattern of the Sm-Co 2:17-type magnets with high coercivities. Domain walls in a zigzag shape are revealed by means of MFM in final bulk Sm-Co 2:17-type sintered magnets.

  19. Roflumilast: APTA 2217, B9302-107, BY 217, BYK 20869.

    Science.gov (United States)

    2004-01-01

    Roflumilast [APTA 2217, B9302-107, BY 217, BYK 20869] is a selective phosphodiesterase IV inhibitor. It is being developed by Altana Pharma (formerly Byk Gulden), a subsidiary of Altana Group, as an orally administered therapy for asthma, chronic obstructive pulmonary disease (COPD), allergic rhinitis and psoriasis. The drug is awaiting regulatory approval in Europe for the treatment of asthma and COPD. Byk Gulden has stated that roflumilast relieves asthma symptoms through both an anti-inflammatory effect and a muscle relaxant effect. Roflumilast has potential as first-line long-term therapy in mild-to-moderate COPD and as additive long-term therapy in moderate-to-severe COPD. Altana has stated that roflumilast is to be marketed under the brand name Daxas. Altana Group and Pharmacia Corporation (now Pfizer) signed an agreement on 22 April 2002 to collaborate on the development and commercialisation of roflumilast for the treatment of respiratory disorders, including asthma and COPD. The companies will jointly develop the drug for the US, Europe and other markets. Pharmacia will co-ordinate development in the US and Altana will co-ordinate development in Europe. After approval of the drug, Pharmacia and Altana will jointly launch and promote roflumilast in the US, Europe and elsewhere. Altana will receive an upfront payment and additional milestone payments. Altana additionally has the option to co-promote Pharmacia products in the US and elsewhere. On 16 April 2003, Pharmacia Corporation was acquired by, and merged into, Pfizer. In November 2002, Altana and Tanabe Seiyaku signed an agreement to collaborate on the development and commercialisation of roflumilast for the treatment of respiratory diseases, including asthma and COPD. Tanabe Seiyaku and Altana will develop roflumilast for asthma and COPD in Japan, and will jointly launch and co-promote roflumilast in Japan following regulatory approval. Roflumilast has been in multinational phase III clinical studies

  20. 我院2009-2013年药品不良反应报告217例分析%Analysis of adverse reactions of drugs in our hospital from 2009 to 2013:on 217 cases report

    Institute of Scientific and Technical Information of China (English)

    卿常春; 罗锡; 黄春玲

    2014-01-01

    目的:了解该院药品不良反应( ADR)发生的特点及规律,掌握ADR事件发生的特点并制定相应对策,减少ADR事件的伤害。方法2009年1月-2013年11月上报ADR 217例,按性别、年龄、药物制剂、药品种类、给药途径、ADR累积器官或系统及临床表现等方面进行回顾性分析统计。结果217例ADR报告中,静脉滴注给药引发的ADR报告比例最高,占85.25%;涉及药品品种以抗菌药物为首,占38.71%;ADR累计器官或系统主要为皮肤系统,临床表现以皮疹、瘙痒、潮红、红斑为主。结论重视医院开展ADR监测工作,加强相关培训,提高医务人员上报意识,利于为调整医院用药方式及筛选用药品种提供理论依据,确保用药安全。%Objective To investigate the characteristics and general features of adverse drug reactions ( ADR ) oc-curred in our hospital for reference of clinical rational drug administration and to develop better countermeasures ,reducing the ADR event of injury.Methods Retrospectively analyzed the 217 cases ADR reports,collected from January 2009 to November 2013 in the hospital,by gender,age,drug formulations,variety of drugs,route of administration,organs and system related to ADR,clinical manifestations and other aspects .Results Among 217 cases of ADR reports ,the highest proportion of ADR re-ports was caused by administered intravenously , accounting for 85.25%;The ADR induced by antimicrobial drugs was the higheat,accounting for 38.71%;The organ or system related to ADR was skin systems ,the mainly clinical manifestations were skin rash,itching,flushing and erythema .Conclusion It is right to emphasize the ADR monitoring and improve the conscious-ness in order to ensure the clinical rational drug administration .ADR monitoring work carried out in the hospital ,help to pro-vide a theoretical basis for the adjustment of hospital medication and screening of drug varieties , to ensure

  1. Microstructural changes during the slow-cooling annealing of nanocrystalline SmCo 2:17 type magnets

    Energy Technology Data Exchange (ETDEWEB)

    Romero, S.A. [Instituto de Fisica da Universidade de Sao Paulo, Sao Paulo (Brazil); Escola Politecnica da Universidade de Sao Paulo, Sao Paulo (Brazil); Campos, M.F. de, E-mail: mcampos@metal.eeimvr.uff.br [PUVR - Universidade Federal Fluminense, Av. dos Trabalhadores 420, Vila Santa Cecilia, Volta Redonda, RJ 27255-125 (Brazil); Castro, J.A. de [PUVR - Universidade Federal Fluminense, Av. dos Trabalhadores 420, Vila Santa Cecilia, Volta Redonda, RJ 27255-125 (Brazil); Moreira, A.J. [Escola Politecnica da Universidade de Sao Paulo, Sao Paulo (Brazil); Landgraf, F.J.G. [Escola Politecnica da Universidade de Sao Paulo, Sao Paulo (Brazil); Instituto de Pesquisas Tecnologicas do Estado de Sao Paulo, Sao Paulo (Brazil)

    2013-02-25

    Highlights: Black-Right-Pointing-Pointer Use of the Stoner-Wohlfarth Callen Liu Cullen model in 2:17 type magnets. Black-Right-Pointing-Pointer Data suggest exchange coupling between Sm2(CoFe)17 and Sm(CoCu)5 phases. Black-Right-Pointing-Pointer It is given structural data for phase Sm0.33Zr0.67TM3, with TM=Co,Fe,Cu. Black-Right-Pointing-Pointer The beneficial effect of the slow cooling treatment is explained. - Abstract: The microstructure and magnetic properties of 2:17 type isotropic magnets were investigated. The slow cooling heat treatment (cooling at 1 Degree-Sign C/min from 820 to 400 Degree-Sign C, and isothermal treatment during 24 h) was interrupted after the temperatures of 820, 700, 600 and 500 Degree-Sign C and their hysteresis were measured with fields up to 9 T. The fully heat treated sample presented coercivity ({mu}{sub 0}H) of 3.32 T, after 24 h at 400 Degree-Sign C. The microstructure was investigated with SEM-FEG (Scanning Electron Microscope with Field Emission Gun) and X-ray Diffraction Rietveld analysis. The application of the Stoner-Wohlfarth-Callen-Liu-Cullen (SW-CLC) model points out exchange coupling between ferromagnetic Sm{sub 2}(CoFe){sub 17} nanocells and ferromagnetic Sm(CoCu){sub 5} present at the cell boundary phase. The results are interpreted with the double shell model: first-a cobalt-rich ferromagnetic Sm(CoCu){sub 5} shell originates exchange coupling and second-a copper-rich paramagnetic Sm(CuCo){sub 5} shell produces magnetic decoupling. This double shell helps to maximize coercivity and remanence. The anisotropy field of the Sm{sub 2}(CoFe){sub 17} cell phase was estimated in 7 T with the SW-CLC model.

  2. 26 CFR 1.217-1 - Deduction for moving expenses paid or incurred in taxable years beginning before January 1, 1970.

    Science.gov (United States)

    2010-04-01

    .... After working full-time for 30 weeks his job is terminated, and he subsequently moves to and secures... reimbursed $600 by M. After working for M for a period of 3 months, A becomes dissatisfied with the job and... expenses is not disallowed by reason of section 217(c)(2). Example 2. B, a self-employed accountant,...

  3. Status of the 7 MeV/u, 217 MHz Injector Linac for the Heidelberg Cancer Therapy Facility

    CERN Document Server

    Schlitt, B; Hutter, G; Klos, F; Lu, Y; Minaev, S A; Mühle, C; Ratzinger, U; Schlitt, B; Tiede, R; Vinzenz, W; Will, C; Zurkan, O

    2004-01-01

    A clinical synchrotron facility for cancer therapy using energetic proton and ion beams (C, He and O) is under construction and will be installed at the Radiologische Universitätsklinik in Heidelberg, Germany, starting in 2005. The status of the ECR ion source systems, the beam line components of the low energy beam transport lines, the 400 keV/u RFQ and the 20 MV IH-cavity as well as the linac rf system will be reported. Two prototype magnets of the linac quadrupole magnets have been built at GSI and have been tested successfully. A test bench for the 1.4 MW, 217 MHz cavity amplifier built by industry has been installed at GSI including a 120 kW driver amplifier which will be used also for high power tests of the RFQ. A test bench for the RFQ using proton beams is presently being set up at the IAP. RF tuning of the 1:2 scaled IH-DTL model as well as Microwave Studio simulations of the model and the power cavity have been also performed at the IAP [1].

  4. VizieR Online Data Catalog: HK photometry in an UCHII region near Sh2-217 (Brand+, 2011)

    Science.gov (United States)

    Brand, J.; Massi, F.; Zavagno, A.; Deharveng, L.; Lefloch, B.

    2010-11-01

    Coordinates and photometric parameters (magnitudes and colours) are presented of the stars located in a molecular condensation on the SW-border of the Galactic HII region Sh2-217. The data were obtained on January 4, 2004 with the 3.58-m Telescopio Nazionale Galileo (TNG; La Palma, Canary Islands, Spain). Near-infrared observations were carried out through H and K' broad-band filters with the camera NICS. The image scale is 0.25arcsec/pixel, yielding a field of view of about 4.2'x4.2'. Observing strategy and exposure times are described in Deharveng et al. (2006A&A...458..191D), the only difference being that the dithering sequence for the H-band images was the same as adopted for K'. The data reduction steps adopted are outlined in Deharveng et al. (2006A&A...458..191D). Aperture photometry was done using the DAOPHOT package in IRAF. We followed the same procedure described in Deharveng et al. (2006A&A...458..191D) to obtain aperture photometry, after which PSF-fitting photometry was performed. Although the seeing was good (image of a sample of stars and fitting those positions to the equatorial coordinates given by Deharveng et al. (2006A&A...458..191D), using tasks of STSDAS/IRAF. The typical accuracy of this procedure is of the order of 1". (1 data file).

  5. The Planck-ATCA Co-eval Observations (PACO) project: analysis of radio source properties between 5 and 217 GHz

    CERN Document Server

    Massardi, Marcella; Bonavera, Laura; De Zotti, Gianfranco; Lopez-Caniego, Marcos; Galluzzi, Vincenzo

    2015-01-01

    The Planck-ATCA Co-eval Observations (PACO) project has yielded observations of 464 sources with the Australia Telescope Compact Array (ATCA) between 4.5 and 40 GHz. The main purpose of the project was to investigate the spectral properties of mm-selected radio sources at frequencies below and overlapping with the ESA's Planck satellite frequency bands, minimizing the variability effects by observing almost simultaneously with the first two Planck all-sky surveys. In this paper we present the whole catalogue of observations in total intensity. By comparing PACO with the various measures of Planck Catalog of Compact Sources (PCCS) flux densities we found the best consistency with the PCCS "detection pipeline" photometry (DETFLUX) that we used to investigate the spectral properties of sources from 5 to 217 GHz. Of our sources, 91% have remarkably smooth spectrum, well described by a double power law over the full range. This suggests a single emitting region, at variance with the notion that "flat" spectra resu...

  6. Exchange of glutamine-217 to glutamate of Clostridium limosum exoenzyme C3 turns the asparagine-specific ADP-ribosyltransferase into an arginine-modifying enzyme.

    Science.gov (United States)

    Vogelsgesang, Martin; Aktories, Klaus

    2006-01-24

    C3-like ADP-ribosyltransferaseses are produced by Clostridium species, Bacillus cereus, and various Staphylococcus aureus strains. The exoenzymes modify the low-molecular-mass GTPases RhoA, B, and C. In structural studies of C3-like exoenzymes, an ARTT-motif (ADP-ribosylating turn-turn motif) was identified that appears to be involved in substrate specificity and recognition (Han, S., Arvai, A. S., Clancy, S. B., Tainer, J. A. (2001) J. Mol. Biol. 305, 95-107). Exchange of Gln217, which is a key residue of the ARTT-motif, to Glu in C3 from Clostridium limosum results in inhibition of ADP-ribosyltransferase activity toward RhoA. The mutant protein is still capable of NAD-binding and possesses NAD+ glycohydrolase activity. Whereas recombinant wild-type C3 modifies Rho proteins specifically at an asparagine residue (Asn41), Gln217Glu-C3 is capable of ADP-ribosylation of poly-arginine but not poly-asparagine. Soybean trypsin inhibitor, a model substrate for many arginine-specific ADP-ribosyltransferases, is modified by the Gln217Glu-C3 transferase. Also in C3 ADP-ribosyltransferases from Clostridium botulinum and B. cereus, the exchange of the equivalent Gln residue to Glu blocked asparagine modification of RhoA but elicited arginine-specific ADP-ribosylation. Moreover, the Gln217Glu-C3lim transferase was able to ADP-ribosylate recombinant wild-type C3lim at Arg86, resulting in decrease in ADP-ribosyltransferase activity of the wild-type enzyme. The data indicate that the exchange of one amino acid residue in the ARTT-motif turns the asparagine-modifying ADP-ribosyltransferases of the C3 family into arginine-ADP-ribosylating transferases.

  7. Comparative M-H Characteristics of 1-5 and 2-17 Type Samarium-Cobalt Permanent Magnets to 300 C

    Science.gov (United States)

    Niedra, Janis M.

    1994-01-01

    Recent consideration of the use of permanent magnets in space power converters at heat rejection temperatures exceeding 250 C and in miniature high temperature actuators is supporting a search for permanent magnets resistant to demagnetizing forces at high temperature. The present paper investigates the short-term demagnetization resistance to applied bucking fields and at temperatures up to 300 C of SmCo5 type magnets, in the form of 1-cm cubes, from several commercial sources. Quasistatic, 2nd quadrant M-H data taken at selected temperatures are the source of derived plots which are then compared to similar data for previously tested Sm2Co17 type magnets. The 1-5 magnet remanence tends to be about 1.5 kG below that of the 2-17 magnets throughout the temperature range. However, the intrinsic coercivities and M-H curve 'knee-fields' seen in particular 1-5 magnets were considerably above those seen previously in the 2-17 magnets. This superior resistance to demagnetizing fields attainable in 1-5 magnets is also illustrated by safe operating area plots based on the knee-field, the magnetic induction swing and temperature. Comments are made on the possibility that a remanence versus knee-field tradeoff can make 1-5 material competitive with 2-17 in applications where a magnet has to withstand large bucking fields at high temperature.

  8. Investigating the effects of 217 Hz frequency of cell phone on learning and spatial memory in rats

    Directory of Open Access Journals (Sweden)

    Kohzad S

    2013-03-01

    Full Text Available Background: Extremely low frequency (0-300 Hz fields from power lines, electronic equipment and medical devices, have been reported to produce various biological effects. Global system for mobile (GSM is most largely used in everybody's life. This system utilizes a low frequency band as well as a high frequency range of electromagnetic field. This study investigated the effects of 217 Hz electromagnetic field (the modulating signal in GSM on spatial learning and memory in rat.Methods: Twenty four male Wistar rat (200- 250 g were randomly divided in to three groups as: test, sham and control. Using a Helmholtz coil system, the test group was exposed to a uniform pulsed EMF of 200 µT (micro Tesla intensity for 4 h/day for 21 days (2 time in a day. This procedure was repeated for the sham group but with no field. All groups were trained prior to the day 21 on the 15th day for five days four trial per day in Morris Water-Maze system. Then the probe test was carried out for 60 seconds with no platform.Results: The ANOVA test revealed that no significant differences were found between control and exposed rats in all day of learning acquisition. Also, in probe test for investigating the memory, no significant differences observed. (P≤0.05 is accepted for significant level.Conclusion: This finding is in consistent with previous studies and indicates low frequency band of electromagnetic fields (EMF (200 µT intensity in cell phone may not have any effect on the learning acquisition and spatial memory in rat.

  9. Expression of mRNA and protein of ZNF217 and EF1α and their significance in pathological scar%锌指基因217和翻译延伸因子1α在病理性瘢痕组织中的表达和意义

    Institute of Scientific and Technical Information of China (English)

    吴文艺; 王小影; 张丽婷; 郑志芳; 朱世泽; 王朝阳

    2012-01-01

    目的 探讨锌指基因217(ZNF217)和翻译延伸因子1α(EF1α)在病理性癜痕中的表达及其相互关系,以及它们在瘢痕形成中的作用及机制,为瘢痕防治提供实验依据.方法 利用实时荧光定量聚合酶链式反应(PCR)法、蛋白质免疫印迹(Western印迹)法检测正常皮肤、成熟瘢痕、增生性瘢痕和瘢痕疙瘩组织中ZNF217和EF1α的mRNA、蛋白相对表达水平.结果 正常皮肤、成熟瘢痕、增生性瘢痕和瘢痕疙瘩组织中ZNF217的mRNA及蛋白质相对表达量分别为1.46±0.397、1.45±0.265、4.49±0.999、5.47±0.808;0.276±0.0211、0.299±0.0150、0.743±0.0509、0.747±0.0377.EF1α的mRNA及蛋白质相对表达量分别为1.47±0.469、1.47±0.218、5.10±1.680、5.74±1.920;0.505±0.0371、0.518±0.0153、0.780土0.0369、0.792±0.0290.病理性瘢痕组织中ZNF217的mRNA及蛋白质表达显著高于正常皮肤、成熟瘢痕(P<0.01);病理性瘢痕组织中EF1α的mRNA及蛋白质表达增高,与正常皮肤、成熟瘢痕对照组比较,差异有统计学意义(P<0.01);病理性瘢痕组织中ZNF217的mRNA及蛋白质表达与EF1α的mRNA及蛋白质表达呈正相关.结论 ZNF217在病理性瘢痕组织中表达增高,可能通过调节EF1α等细胞周期调控因子而促进瘢痕组织中细胞的增生,对病理性瘢痕的形成可能起着重要作用.%Objective To study the expression of ZNF217 and EF1α gene in the pathological scars and to investigate role and probable mechanism in the pathogenesis of abnormal scar.Methods Quantitative real-time PCR and Western blot were performed to detect the expression and distribution of mRNA and protein of ZNF217 and EF1α in hypertrophic scar (10 cases),keloid (10 cases),normal scar (10 cases),and normal skin (10 cases),and statistics was used to analyze the data.Results The expression of ZNF217 mRNA and protein in the normal skin,normal scar,hypertrophic scar and keloid were 1.46±0.397,1.45±0.265,4.49±0.999,5.47±0

  10. The Effect of 217 Hz Magnetic Field of Cell Phone with Different Intensities on Apoptosis of Normal and Cancerous Cells Treated with Chemotherapy Drug

    Directory of Open Access Journals (Sweden)

    Mahsa Mansourian

    2012-03-01

    Full Text Available Background: According to the increasing development of home and business electronic equipment in today's world, the biological effects of ELF magnetic fields have been studied at two molecular-cellular and animal- human levels. Considering the therapeutic viewpoint of this study regarding the effects of low-frequency fields of mobile phone, the effect of acute exposure to this field on chemotherapy will be studied.Materials and Methods: In this experimental study, based on measurement of the intensity of the magnetic fields from mobile phones in another research, flux densities of magnetic field of 159.44, 93.25 and 120µ tesla with frequency of 217Hz was generated in magnetic field generator system, and the apoptosis level in K562 cancer cells and healthy cells of lymphocytes was assessed after exposure to field using flow cytometry method. This evaluation method was also performed for the cells treated with bleomycin after exposure to this field.Results: 217 Hz magnetic field exposure significantly increases the rate of apoptosis percentage (p > 0.05 in K562 cancer cells and in two intensities of 120 and 159.44µ tesla compared to the control group, but such effect is not observed in lymphocyte cells. Bleomycin-induced apoptosis percentage following exposure to the mentioned magnetic field shows no significant difference compared to the group of treatment with drug and without field exposure. This lack of significant difference is observed between the groups of drug after field exposure and field alone as well as between groups exposed to field and groups treated with bleomycin.Conclusion: Study results showed that 217 Hz magnetic field of mobile phone can induce apoptosis on cancer cells, but it has no effect on healthy cells. Thus, in order to use mobile phone as an effective factor in their treatment, some studies should be conducted at animal-human level.

  11. ExoMol molecular line lists XIX: high-accuracy computed hot line lists for H218O and H217O

    Science.gov (United States)

    Polyansky, Oleg L.; Kyuberis, Aleksandra A.; Lodi, Lorenzo; Tennyson, Jonathan; Yurchenko, Sergei N.; Ovsyannikov, Roman I.; Zobov, Nikolai F.

    2017-04-01

    Hot line lists for two isotopologues of water, H218O and H217O, are presented. The calculations employ newly constructed potential energy surfaces (PES), which take advantage of a novel method for using the large set of experimental energy levels for H216O to give high-quality predictions for H218O and H217O. This procedure greatly extends the energy range for which a PES can be accurately determined, allowing an accurate prediction of higher lying energy levels than are currently known from direct laboratory measurements. This PES is combined with a high-accuracy, ab initio dipole moment surface of water in the computation of all energy levels, transition frequencies and associated Einstein A coefficients for states with rotational excitation up to J = 50 and energies up to 30 000 cm-1. The resulting HotWat78 line lists complement the well-used BT2 H216O line list. Full line lists are made available online as Supporting Information and at www.exomol.com.

  12. Role of the non-opioid dynorphin peptide des-Tyr-dynorphin (DYN-A(2-17)) in food intake and physical activity, and its interaction with orexin-A.

    Science.gov (United States)

    Gac, L; Butterick, T A; Duffy, C M; Teske, J A; Perez-Leighton, C E

    2016-02-01

    Food intake and physical activity are regulated by multiple neuropeptides, including orexin and dynorphin (DYN). Orexin-A (OXA) is one of two orexin peptides with robust roles in regulation of food intake and spontaneous physical activity (SPA). DYN collectively refers to several peptides, some of which act through opioid receptors (opioid DYN) and some whose biological effects are not mediated by opioid receptors (non-opioid DYN). While opioid DYN is known to increase food intake, the effects of non-opioid DYN peptides on food intake and SPA are unknown. Neurons that co-express and release OXA and DYN are located within the lateral hypothalamus. Limited evidence suggests that OXA and opioid DYN peptides can interact to modulate some aspects of behaviors classically related to orexin peptide function. The paraventricular hypothalamic nucleus (PVN) is a brain area where OXA and DYN peptides might interact to modulate food intake and SPA. We demonstrate that injection of des-Tyr-dynorphin (DYN-A(2-17), a non opioid DYN peptide) into the PVN increases food intake and SPA in adult mice. Co-injection of DYN-A(2-17) and OXA in the PVN further increases food intake compared to DYN-A(2-17) or OXA alone. This is the first report describing the effects of non-opioid DYN-A(2-17) on food intake and SPA, and suggests that DYN-A(2-17) interacts with OXA in the PVN to modulate food intake. Our data suggest a novel function for non-opioid DYN-A(2-17) on food intake, supporting the concept that some behavioral effects of the orexin neurons result from combined actions of the orexin and DYN peptides.

  13. Estimate of the anisotropy field in isotropic SmCo 2:17 magnets with the Stoner-Wohlfarth CLC model

    Energy Technology Data Exchange (ETDEWEB)

    De Campos, M F [PUVR- Universidade Federal Fluminense, Av dos Trabalhadores 420, Vila Santa Cecilia, Volta Redonda, RJ, 27255-125 (Brazil); Romero, S A [Instituto de Fisica, Universidade de Sao Paulo, Sao Paulo, SP (Brazil); Landgraf, F J G [Escola Politecnica, Universidade de Sao Paulo, Sao Paulo, SP (Brazil); Missell, F P, E-mail: fmissell@yahoo.com, E-mail: mcampos@metal.eeimvr.uff.br [Centro de Ciencias Exatas e Tecnologia, Universidade de Caxias do Sul, Caxias do Sul, RS, 95070-560 Brazil (Brazil)

    2011-07-06

    The Callen-Liu-Cullen (CLC) modification of the Stoner-Wohlfarth model was found able to describe properly the hysteresis curves of isotropic Sm(CoFeCuZr)z magnets. The SW-CLC model uses three parameters, and all of them have physical meaning. One of the parameters is related to the saturation magnetization, another to the anisotropy field, and another is 1/d, which evaluates the interaction between grains or particles. The model was applied for several magnets, indicating an anisotropy field of 6-7 T, which is compatible with other methods for anisotropy field determination. The model also gives insight into the abnormal temperature dependence of the coercivity found in SmCo 2:17 magnets. For compositions with a low z, the parameter 1/d is significant. These compositions with a low z are those showing the most abnormal coercivity behavior with temperature.

  14. Pre-eruptive conditions of dacitic magma erupted during the 21.7 ka Plinian event at Nevado de Toluca volcano, Central Mexico

    Science.gov (United States)

    Arce, J. L.; Gardner, J. E.; Macías, J. L.

    2013-01-01

    The Nevado de Toluca volcano in Central Mexico has been active over the last ca. 42 ka, during which tens of km3 of pyroclastic material were erupted and two important Plinian-type eruptions occurred at ca. 21.7 ka (Lower Toluca Pumice: LTP) and ca. 10.5 ka (Upper Toluca Pumice: UTP). Samples from both the LTP and UTP contain plagioclase, amphibole, iron-titanium oxides, and minor anhedral biotite, set in a vesicular, rhyolitic, glassy matrix. In addition, UTP dacites contain orthopyroxene. Analysis of melt inclusions in plagioclase phenocrysts yields H2O contents of 2-3.5 wt.% for LTP and 1.3-3.6 wt.% for UTP samples. Ilmenite-ulvospinel geothermometry yields an average temperature of ~ 868 °C for the LTP magma (hotter than the UTP magma, ~ 842 °C; Arce et al., 2006), whereas amphibole-plagioclase geothermometry yields a temperature of 825-859 °C for the LTP magma. Water-saturated experiments using LTP dacite suggest that: (i) amphibole is stable above 100 MPa and below 900 °C; (ii) plagioclase crystallizes below 250-100 MPa at temperatures of 850-900 °C; and (iii) pyroxene is stable only below pressures of 200-100 MPa and temperatures of 825-900 °C. Comparison of natural and experimental data suggests that the LTP dacitic magma was stored at 150-200 MPa (5.8-7.7 km below the volcano summit). No differences in pressure found between 21.7 ka and 10.5 ka suggest that these two magmas were stored at similar depths. Orthopyroxene produced in lower temperature LTP experiments is compositionally different to those found in UTP natural samples, suggesting that they originated in two different magma batches. Whole-rock chemistry, petrographic features, and mineral compositions suggest that magma mixing was responsible for the generation of the dacitic Plinian LTP eruption.

  15. La metáfora de la gestación y del parto al servicio de la analogía. Una lectura de Sal 2,1-7. [Reseña

    OpenAIRE

    Heras-Oliver, G. (Gloria)

    2004-01-01

    Reseña de Lourdes GARCÍA UREÑA, La metáfora de la gestación y del parto al servicio de la analogía. Una lectura de Sal 2,1-7, Pontificia Universidad de la Santa Cruz, Roma 2003, 280 pp., 17 x 24, ISBN 88-8333-071-4.

  16. Regulatory Assistance, Stakeholder Outreach, and Coastal and Marine Spatial Planning Activities In Support Marine and Hydrokinetic Energy Deployment: Task 2.1.7 Permitting and Planning Fiscal Year 2012 Year-End Report

    Energy Technology Data Exchange (ETDEWEB)

    Geerlofs, Simon H.; Hanna, Luke A.; Judd, Chaeli R.; Blake, Kara M.

    2012-09-01

    This fiscal year 2012 year-end report summarizes activities carried out under DOE Water Power task 2.1.7, Permitting and Planning. Activities under Task 2.1.7 address the concerns of a wide range of stakeholders with an interest in the development of the MHK industry, including regulatory and resource management agencies, tribes, NGOs, and industry. Objectives for 2.1.7 are the following: • To work with stakeholders to streamline the MHK regulatory permitting process. • To work with stakeholders to gather information on needs and priorities for environmental assessment of MHK development. • To communicate research findings and directions to the MHK industry and stakeholders. • To engage in spatial planning processes in order to further the development of the MHK industry. These objectives are met through three subtasks, each of which are described in this report: • 2.1.7.1—Regulatory Assistance • 2.1.7.2—Stakeholder Outreach • 2.1.7.3—Coastal and Marine Spatial Planning As the MHK industry works with the regulatory community and stakeholders to plan, site, permit and license MHK technologies they have an interest in a predictable, efficient, and transparent process. Stakeholders and regulators have an interest in processes that result in sustainable use of ocean space with minimal effects to existing ocean users. Both stakeholders and regulators have an interest in avoiding legal challenges by meeting the intent of federal, state, and local laws that govern siting and operation of MHK technologies. The intention of work under 2.1.7 is to understand these varied interests, explore mechanisms to reduce conflict, identify efficiencies, and ultimately identify pathways to reduce the regulatory costs, time, and potential environmental impacts associated with developing, siting, permitting, and deploying MHK systems.

  17. Analysis of 217 Strains Bacteria and their Drug Susceptibility from Hospitalized Children with Lower Respiratory Tract Infections%儿童下呼吸道感染217株细菌分析及药物敏感趋势监测

    Institute of Scientific and Technical Information of China (English)

    方敏; 何邱宁

    2012-01-01

    目的:了解儿童下呼吸道感染致病菌的流行趋势和药物敏感性,为临床合理用药提供依据.方法:对2010年3月1日~2011年8月31日在我科住院的下呼吸道感染患儿痰液标本中分离出的病原菌进行药物敏感性监测分析.结果:共分离出217株病原菌.G-杆菌以大肠埃希菌(28.11%)、解鸟氨酸克雷伯菌(7.37%)、洛菲不动杆菌(6.91%)为主;G+菌以腐生葡萄球菌(9.68%)、表皮葡萄球菌(6.45%)、金黄色葡萄球菌(3.69%)为主.G-杆菌对第三代头孢菌素中的头孢他啶、头孢吡肟、氨曲南、亚胺培南、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、阿米卡星等抗生素敏感性高;G+球菌对青霉素、红霉素、克林霉素及阿奇霉素耐药率高,对其他抗生素敏感.超广谱β-内酰胺酶(ESBLs)的确证试验结果:61株大肠埃希菌产酶率55.74%;21株腐生葡萄球菌、耐甲氧西林凝固酶阴性葡萄球菌(MRSCN)产酶率9.52%,14株表皮葡萄球菌MRSCN的产酶率7.14%;5株屎肠球菌高水平氨基糖苷类耐药株( HLAR)40.00%,4株粪肠球菌HLAR为25.00%.结论:加强细菌培养和耐药性监测对临床合理使用抗生素十分必要.%Objective;To investigate the trend of lower respiratory tract infections in children and drug susceptibility to provide basis for reasonable use of drugs in clinical practice. Methods; A total of 217 strains of bacteria were isolated from sputum specimen of children who were hospitalized with lower respiratory tract infections form March 2010 to August 2011 in our hospital. The bacteria were cultured with blood dish and identified. Drug susceptibility was monitored. Results; 217 strains of bacteria were isolated. The first three places of Cram-negative bacilli were Escherichia coli (28. 11%), Klebsiella omithinolytica (7.37%) and Acinetobacter lwoffi (6.91%). The first three places of Cram-positive cocci were S. saprophyticus (9. 68% ) , S. epidermidis (6

  18. Molecular dynamics simulation and free energy landscape methods in probing L215H, L217R and L225M βI-tubulin mutations causing paclitaxel resistance in cancer cells.

    Science.gov (United States)

    Tripathi, Shubhandra; Srivastava, Gaurava; Sharma, Ashok

    2016-08-05

    Drug resistance poses a threatening challenge for mankind, as the development of resistance to already well-established drugs causes serious therapeutic problems. Resistance to paclitaxel (Ptxl), a complex diterpenoid working as microtubule stabilizer, is one such issue in cancer treatment. Microtubule stabilizer drugs, stabilises microtubules upon binding to β-tubulin subunit of tubulin heterodimer thus causing mitotic arrest leading to death of cancer cell. Leucine point mutations viz. L215H, L217R, and L225M were reported for Ptxl resistance in various cancers. In the current study, molecular mechanism of these resistance causing mutations was explored using molecular docking, molecular dynamics (MD) simulation, binding energy estimation (MMPBSA), free energy decomposition, principle component analysis (PCA) and free energy landscape (FEL) methods. A total of five systems including unbound βI-tubulin (Apo), docked wild+Ptxl, L215H+Ptxl, L217R+Ptxl and L225M+Ptxl were prepared, and 50 ns MD simulation was performed for each system. Binding energy estimation indicated that leucine mutation reduces the binding affinity of Ptxl in mutant types (MTs) as compared to wild type (WT). Further, in contrast to WT Ptxl interactions with the M-loop (PHE270-VAL286), S6-S7 loop and H9-H10 were significantly altered in MTs. Results showed that in MTs, Ptxl had weak interaction with M-loop residues, while having strong affinity with S6-S7 loop and H6-H7 loop. Moreover, PCA and FEL analysis revealed that M-loop flexible region (THR274-LEU284) was strongly bound with Ptxl in WT preventing its flexible movement and the causing factor for microtubule stabilization. In MTs due to poor interaction with Ptxl, M-loop flexible region retains its flexibility, therefore unable to stabilize microtubule. This study will give an insight into the importance of M-loop flexible region interaction with Ptxl for microtubule stabilization. In addition, it clearly provides the molecular basis of

  19. Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines

    Directory of Open Access Journals (Sweden)

    Mary J. Eaton

    2012-01-01

    Full Text Available Effective treatment of sensory neuropathies in peripheral neuropathies and spinal cord injury (SCI is one of the most difficult problems in modern clinical practice. Cell therapy to release antinociceptive agents near the injured spinal cord is a logical next step in the development of treatment modalities. But few clinical trials, especially for chronic pain, have tested the potential of transplant of cells to treat chronic pain. Cell lines derived from the human neuronal NT2 cell line parentage, the hNT2.17 and hNT2.19 lines, which synthesize and release the neurotransmitters gamma-aminobutyric acid (GABA and serotonin (5HT, respectively, have been used to evaluate the potential of cell-based release of antinociceptive agents near the lumbar dorsal (horn spinal sensory cell centers to relieve neuropathic pain after PNS (partial nerve and diabetes-related injury and CNS (spinal cord injury damage in rat models. Both cell lines transplants potently and permanently reverse behavioral hypersensitivity without inducing tumors or other complications after grafting. Functioning as cellular minipumps for antinociception, human neuronal precursors, like these NT2-derived cell lines, would likely provide a useful adjuvant or replacement for current pharmacological treatments for neuropathic pain.

  20. Comment on “Stratigraphy, petrography and dispersion of the lower Permian syn-eruptive deposits in the Viar Basin, Spain” by S. Sierra, C. Moreno and E. Pascual [Sedimentary Geology 217 (2009) 1-29

    Science.gov (United States)

    Wagner, R. H.; Mayoral, E.

    2010-07-01

    Comments are provided on a published paper on "Lower Permian" strata in SW Spain [S. Sierra, C. Moreno and E. Pascual, Stratigraphy, petrography and dispersion of the lower Permian syn-eruptive deposits in the Viar Basin, Spain, Sedimentary Geology 217 (2009) 1-29], which failed to take into account up-to-date information on this most southerly occurrence in western Europe. This generally lacustrine basin commenced with valley fill deposits in a deeply incised palaeotopography and contains mainly red beds with two basaltic intervals and a major acidic volcanic episode linked to a nearby volcanic centre to the Northeast. The stratigraphic succession shows southeasterly onlap. Although a syn-sedimentary fault has been postulated on the NE basin margin, the field evidence disproves this notion as well as the assumption that this "Early Permian" basin would have been controlled by a rejuvenated Ossa-Morena/South Portuguese boundary fault. In fact, this basin lies within the (former) area of Ossa-Morena.

  1. Novel deletion and a new missense mutation (Glu 217 Lys) at the catalytic site in two adenosine deaminase alleles of a patient with neonatal onset adenosine deaminase severe combined immunodeficiency

    Energy Technology Data Exchange (ETDEWEB)

    Hirschhorn, R.; Nicknam, M.N.; Eng, F.; Yang, D.R.; Borkowsky, W. (New York Univ. Medical School of Medicine, NY (United States))

    1992-11-01

    Mutations at the adenosine deaminase (ADA) locus result in a spectrum of disorders, encompassing a fulminant neonatal onset severe combined immunodeficiency (SCID) and childhood onset immunodeficiency, as well as apparently normal immune function. The extent of accumulation of the toxic metabolite, deoxyATP, correlates directly with severity of disease. The authors have now determined the mutations on both alleles of a child with fulminant, neonatal onset ADA SCID and accumulation of extremely high concentrations of deoxyATP. The genotype was consistent with the severely affected phenotype. One allele carried a large deletion that arose by non-homologous recombination and included the first five exons and promoter region. The second allele carried a missense mutation (G[sup 649]A) resulting in replacement of Glu[sup 217], an amino acid involved in the catalytic site, by Lys and predicting a major alteration in charge. Expression of the mutant cDNA on Cos cells confirmed that the mutation abolished enzyme activity. The authors have previously reported that a missense mutation at the preceding codon is similarly associated with neonatal onset ADA SCID and accumulation of extremely high deoxyATP. These findings suggest that genotype-phenotype correlations may be apparent for ADA SCID, despite the role that random variation in exposure to environmental pathogens may play in the initial phenotype. Such genotype-phenotype correlations may be important to consider in evaluating results of ongoing trials of [open quotes]gene[close quotes] and enzyme replacement therapy. 50 refs., 5 figs., 2 tabs.

  2. 22 CFR 217.13 - Employment criteria.

    Science.gov (United States)

    2010-04-01

    ..., the test results accurately reflect the applicant's or employee's job skills, aptitude, or whatever... criteria. (a) A recipient may not make use of any employment test or other selection criterion that screens... test score or other selection criterion, as used by the recipient, is shown to be job-related for...

  3. 48 CFR 217.7303 - Solicitation provision.

    Science.gov (United States)

    2010-10-01

    ... information was obtained under other acquisitions); (3) The contract is for subsistence, clothing or textiles, fuels, or supplies purchased and used outside the United States; (4) The contracting officer determines...., nonrepetitive local purchases; or (5) The contracting officer determines that the exception at...

  4. 14 CFR 217.10 - Instructions.

    Science.gov (United States)

    2010-01-01

    ... these joint service operations are: Blocked-space agreements; Part-charter agreements; Code-sharing agreements; Wet-lease agreements, and similar arrangements. (2) Joint-service operations shall be reported...

  5. 14 CFR 217.1 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... agreements, part-charters, code-sharing or wet-leases, between two direct air carriers holding underlying economic authority from the Department. Wet-Lease Agreement means an agreement under which one carrier... authorized by the air carrier or another carrier traveling pursuant to a pass interchange agreement;...

  6. 22 CFR 217.14 - Preemployment inquiries.

    Science.gov (United States)

    2010-04-01

    ...) The recipient states clearly on any written questionnaire used for this purpose or makes clear orally if no written questionnaire is used that the information requested is intended for use solely...

  7. 22 CFR 217.47 - Nonacademic services.

    Science.gov (United States)

    2010-04-01

    ... if no qualified handicapped student is denied the opportunity to compete for teams or to participate...) Social organizations. A recipient that provides significant assistance to fraternities, sororities, or similar organizations shall assure itself that the membership practices of such organizations do...

  8. Adolescent Alcohol Abuse. Fastback Series No. 217.

    Science.gov (United States)

    Horton, Lowell

    This booklet examines the problem of alcohol use among American teenagers. The role that alcohol plays in adult society is presented and its potential danger for causing teenage alcohol addiction is considered. A discussion on why some teenagers abuse alcohol focuses on familial, peer, sociocultural, environmental, personality, and behavioral…

  9. 22 CFR 217.3 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... means any state or its political subdivision, any instrumentality of a state or its political... plan required to be approved by an Agency official or by a recipient as a condition to becoming a... and conditions as orthopedic, visual, speech and hearing impairments, cerebral palsy,...

  10. 8 CFR 217.2 - Eligibility.

    Science.gov (United States)

    2010-01-01

    ... authorized agent of any commercial vessel or commercial aircraft engaged in transporting passengers to the... for return passage for charter flights, and military travel orders which include military dependents... territory or an adjacent island, if the traveler is a resident of the country of destination. (2)...

  11. 14 CFR 217.11 - Reporting compliance.

    Science.gov (United States)

    2010-01-01

    ...) Title 18 U.S.C. 1001, Crimes and Criminal Procedure, makes it a criminal offense subject to a maximum... REGULATIONS REPORTING TRAFFIC STATISTICS BY FOREIGN AIR CARRIERS IN CIVILIAN SCHEDULED, CHARTER,...

  12. 12 CFR 217.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... that is considered to be a deposit under § 204.2(a) of the Board's Regulation D—Reserve Requirements of... bank under § 204.2(o) of the Board's Regulation D—Reserve Requirements of Depository Institutions (12... Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM PROHIBITION AGAINST...

  13. 50 CFR 217.204 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ...) prior to using an impact hammer. (7) In-water impact pile driving shall not occur during the period from..., respectively. If a marine mammal is detected within or approaching a distance 200 m from in-water pile driving or in-water chipping, operations shall be immediately delayed or suspended until the marine...

  14. 20 CFR 498.217 - Evidence.

    Science.gov (United States)

    2010-04-01

    ... value is substantially outweighed by the danger of unfair prejudice, confusion of the issues, or by considerations of undue delay or needless presentation of cumulative evidence. (d) Although relevant,...

  15. 6 CFR 21.7 - Assurances required.

    Science.gov (United States)

    2010-01-01

    ..., COLOR, OR NATIONAL ORIGIN IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM THE... give reasonable guarantee that the applicant and all recipients of Federal financial assistance...

  16. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  17. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  18. 49 CFR 571.217 - Standard No. 217; Bus emergency exits and window retention and release.

    Science.gov (United States)

    2010-10-01

    ... centerline. Post and roof bow panel space means the area between two adjacent post and roof bows. Push-out... two side emergency exit doors shall be located, in whole or in part, within the same post and roof bow panel space. (b) Emergency roof exit. (1) Each emergency roof exit shall be hinged on its forward...

  19. Synthesis and identification of 2-(2-hydroxyethoxy)-17β-hydroxy-2,17α-dimethyl-A-nor-5α-androstane,a by-product of oxandrolone during its synthesis%氧甲氢龙合成中伴生副产物2-(2-羟基乙氧基)-17β-羟基-2,17α-二甲基-A-失碳-5α-雄甾烷的鉴定与合成

    Institute of Scientific and Technical Information of China (English)

    屈洁; 饶志威; 左文果; 赵徐波; 李宗桃

    2012-01-01

    目的 为改进氧甲氢龙的合成工艺及提高产率提供实验依据.方法 通过柱色谱、重结晶等方法分离纯化合成氧甲氢龙过程中发现的副产物,经IR、1H-NMR、3C-NMR、MS、元素分析、X-单晶衍射实验等分析手段确证副产物的化学结构;推测副产物的形成机制并按此机制合成该副产物.结果与结论 鉴定副产物为2-(2-羟基乙氧基)-17β-羟基-2,17α-二甲基-A-失碳-Sα-雄甾烷,其形成机制可能是格氏试剂形成的甲基负离子在进攻中间体(7)17位的羰基碳的同时,一部分的甲基负离子从甾体平面结构的下方进攻了2位的乙缩酮的碳原子进而生成该副产物.准确分析出副产物的化学结构及形成机制.%Oxandrolone is an anabolic hormone drug and has strong anabolic effect with no obvious andro-genic effect. In synthesizing 2,2-ethandiyldioxy-17α-methyl-A-nor-5α-androstan-17β-ol which is one of the important intermediate of oxandrolone, a by-product was separated by column chromatography. The chemical structure of this by-product was confirmed as 2-(2-hydroxyethoxy)-17β-hydroxy-2,17αdirnethyl-A-nor-5α-androstane by melting point,IR,1H-NMR,13C-NMR,MS,and elemental analysis. Then the by-product was synthesized in order to study its possible formation mechanism. The result showed that the ketal structure is cleavaged in the presence of excessive methylmagnesium iodide that attacked 2-carbon when the methylmag-nesium iodide attacked 17-carbon.

  20. 29 CFR 1910.217 - Mechanical power presses.

    Science.gov (United States)

    2010-07-01

    ... readily removable by operator, so as to minimize the possibility of misuse or removal of essential parts... application of all operators' controls to activate the slide. The removal of a hand from any control button... reduce the possibility of unintended and uncontrolled press strokes caused by bearing seizure. (5)...

  1. 1935 15' Quad #217 Aerial Photo Mosaic Index - AZ

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  2. Dicty_cDB: CHD217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available isozyme 3 mRNA, complete cds. 58 2e-07 2 CK273593 |CK273593.1 EST719671 potato abiotic stress cDNA library ... An expressed sequence tag database for abiotic stressed leaves of Vitis vinifera...6D06_332552 An expressed sequence tag database for abiotic stressed leaves of Vitis vinifera var. Chardonnay...214.1 VVB158G03_410335 An expressed sequence tag database for abiotic stressed leaves of Vitis vinifera var.

  3. 7 CFR 2.17 - Under Secretary for Rural Development.

    Science.gov (United States)

    2010-01-01

    ... formulating manpower development and training policies. (13) Related to committee management. Establish and... covered work; and emergency procurement powers; (iii) Section 104(i)(11) of the Act (42 U.S.C. 9604(i)(11)), with respect to the reduction of exposure to significant risk to human health; (iv) Section 104(j)...

  4. 48 CFR 52.217-2 - Cancellation Under Multiyear Contracts.

    Science.gov (United States)

    2010-10-01

    ... shall be considered a termination under the Termination for Convenience of the Government clause. (c) If... it as if the claim were being made under the Termination for Convenience of the Government clause of... services which are multiyear requirements; (2) Allocable portions of the costs of facilities acquired...

  5. 18 CFR 157.217 - Changes in rate schedules.

    Science.gov (United States)

    2010-04-01

    ... CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL... authorization. The certificate holder is authorized to permit an existing customer, at the customer's request... limitations on deliveries to the customer under both rate schedules are not increased, for either annual...

  6. Dicty_cDB: VHN217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 25 ) Dictyostelium discoideum cDNA clone:ddv50l04, 3' ... 1094 0.0 3 ( BJ442653 )... Dictyostelium discoideum cDNA clone:ddv50f18, 3' ... 1076 0.0 4 ( BJ445359 ) Dictyostelium discoideum cDNA ...clone:ddv59a09, 3' ... 1007 0.0 3 ( BJ442499 ) Dictyostelium discoideum cDNA clone:ddv50g01, 3' ... 999 0.0

  7. Dicty_cDB: VHF217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Dictyostelium discoideum cDNA clone:ddv50j21, 5' ... 100 3e-17 1 ( BJ423810 ) Di...ctyostelium discoideum cDNA clone:ddv50a16, 5' ... 100 3e-17 1 ( BJ423633 ) Dictyostelium discoideum cDNA cl

  8. 34 CFR 685.217 - Teacher loan forgiveness program.

    Science.gov (United States)

    2010-07-01

    ... classroom teaching or classroom-type teaching in a non-classroom setting, including Special Education... Management and Budget under control number 1845-0021) (Authority: 20 U.S.C. 1087a et seq.)...

  9. 22 CFR 217.42 - Admissions and recruitment.

    Science.gov (United States)

    2010-04-01

    ... applicant who has a handicap that impairs sensory, manual, or speaking skills, the test results accurately... denied admission or be subjected to discrimination in admission or recruitment by a recipient to which... who may be admitted; (2) May not make use of any test or criterion for admission that has...

  10. 78 FR 217 - Shared Responsibility for Employers Regarding Health Coverage

    Science.gov (United States)

    2013-01-02

    ...)(ii) refers, and that interpret the Migrant and Seasonal Agricultural Workers Protection Act, provide... if the employee's required contribution for that coverage was no more than 9.5 percent of the... affordable if the employee's required contribution (within the meaning of section 5000A(e)(1)(B)) for...

  11. Dicty_cDB: SHH217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1 Dictyostelium discoideum H6 gene mRNA. 131 4e-31 2 BI863585 |BI863585.1 kx46a06.y1 Parastrongyloides... trichosuri FL pAMP1 v1 Chiapelli McCarter Parastrongyloides trichosuri cDNA 5' similar... to SW:EF2_CAEEL P29691 ELONGATION FACTOR 2 ;, mRNA sequence. 66 3e-19 4 BI863575 |BI863575.1 kx45h07.y1 Parastrongyloides... trichosuri FL pAMP1 v1 Chiapelli McCarter Parastrongyloides tricho...ngyloides trichosuri FL pAMP1 v1 Chiapelli McCarter Parastrongyloides trichosuri cD

  12. Dicty_cDB: VFN217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available e lnsniyi*ii*kwtvkmfkl*lsitvlvcvkpvllvmmphvlfshqllvvqdtlvlwsvw vkkthm*vmkpnqrevs*psntqlntvslptgmiwkksgiilstm...kmfkl*lsitvlvcvkpvllvmmphvlfshqllvvqdtlvlwsvw vkkthm*vmkpnqrevs*psntqlntvslptgmiwkksgiilstmnsvlpqkntqfs*lk p

  13. 48 CFR 3052.217-95 - Liability and insurance (USCG).

    Science.gov (United States)

    2010-10-01

    ... in USCG guidance at (HSAR) 48 CFR 3017.9000(a) and (b), insert the following clause: Liability and... vessel or its owner, arising in whole or in part from the negligence or other wrongful act of the... Officer may, without prejudice to any right of the Government, either— (1) Order the Contractor to...

  14. 36 CFR 2.17 - Aircraft and air delivery.

    Science.gov (United States)

    2010-07-01

    ... superintendent, or to landings due to circumstances beyond the control of the operator. (c)(1) Except as provided... as a part of these regulations. (e) The operation or use of hovercraft is prohibited. (f)...

  15. Dicty_cDB: VHO217 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CF828602 |CF828602.1 UCRCR01_01N10_r Clementine Mandarin Albedo at Rind Separation cDNA Library Citrus retic...R01_01H10_r Clementine Mandarin Albedo at Rind Separation cDNA Library Citrus reticulata cDNA clone CR_CEa01...28476.1 UCRCR01_01K07_r Clementine Mandarin Albedo at Rind Separation cDNA Library Citrus reticulata cDNA cl

  16. Evaluation of Novel Wet Chemistry Separation and Purification Methods to Facilitate Automation of Astatine-­211 Isolation

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott [Univ. of Washington, Seattle, WA (United States)

    2016-07-19

    This research is a collaborative effort between the research groups of the PIs, Dr. D. Scott Wilbur in the Department of Radiation Oncology at the University of Washington (UW) and Matthew O’Hara at the Pacific Northwest National Laboratory (PNNL). In this report only those studies conducted at UW and the budget information from UW will be reported. A separate progress and financial report will be provided by PNNL. This final report outlines the experiments (Tasks) conducted and results obtained at UW from July 1, 2013 thru June 30, 2016 (2-­year project with 1 year no-­cost extension). The report divides the information on the experiments and results obtained into the 5 specific objectives of the research efforts and the Tasks within those objectives. This format is used so that it is easy to see what has been accomplished in each area. A brief summary of the major findings from the studies is provided below. Summary of Major Findings from Research/Training Activities at UW: Anion and cation exchange columns did not provide adequate 211At capture and/or extraction results under conditions studied to warrant further evaluation; PEG-­Merrifield resins containing mPEG350, mPEG750, mPEG2000 and mPEG5000 were synthesized and evaluated; All of the mPEG resins with different sized mPEG moieties conjugated gave similar 211At capture (>95%) from 8M HCl solutions and release with conc. NH4OH (~50-­80%), but very low quantities were released when NaOH was used as an eluent; Capture and release of 211At when loading [211At]astatate appeared to be similar to that of [211At]astatide on PEG columns, but further studies need to be conducted to confirm that; Capture of 211At on PEG columns was lower (e.g. 80-­90%) from solutions of 8M HNO3, but higher capture rates (e.g. 99%) can be obtained when 10M HNO3 is mixed with an equal quantity of 8M HCl; Addition of reductants to the 211At solutions did not appear to change the percent capture, but may have an effect on the % extracted; There was some indication that the PEG-­Merrifield resins could be saturated (perhaps with Bi) resulting in lower capture percentages, but more studies need to be done to confirm that; A target dissolution chamber, designed and built at PNNL, works well with syringe pumps so it can be used in an automated system; Preliminary semi-­automated 211At isolation studies have been conducted with full scale target dissolution and 211At isolation using a PEG column on the Hamilton automated system gave low overall recoveries, but HNO3 was used (rather than HCl) for loading the 211At and flow rates were not optimized; Results obtained using PEG columns are high enough to warrant further development on a fully automated system; Results obtained also indicate that additional studies are warranted to evaluate other types of columns for 211At separation from bismuth, which allow use of HNO3/HCl mixtures for loading and NaOH for eluting 211At. Such a column could greatly simplify the overall isolation process and make it easier to automate.

  17. Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

    Energy Technology Data Exchange (ETDEWEB)

    Green, Damian J.; Shadman, Mazyar; Jones, Jon C.; Frayo, Shani; Kenoyer, Aimee L.; Hylarides, Mark; Hamlin, Donald K.; Wilbur, D. Scott; Balkan, Ethan R.; Lin, Yukang; Miller, Brian W.; Frost, Sophia; Gopal, Ajay K.; Orozco, Johnnie J.; Gooley, Ted; Laird, Kelley L.; Till, B. G.; Back, Tom; Sandmaier, B. M.; Pagel, John M.; Press, Oliver W.

    2015-03-26

    Alpha emitting radionuclides release a large amount of energy within a few cell diameters and may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD) conditions in which micrometastatic disease satellites are broadly distributed. To evaluate this hypothesis, 211At conjugated 1F5 mAb (anti-CD20) was studied in both bulky lymphoma tumor xenograft and MRD animal models. Superior treatment responses to 211At conjugated 1F5 mAb were evident in the MRD setting. Lymphoma xenograft tumor bearing animals treated with doses of up to 48µCi of anti-CD20 211At-decaborate [211At-B10-1F5] experienced modest responses (0% cures but 2-3-fold prolongation of survival compared to negative controls). In contrast, 70% of animals in the MRD lymphoma model demonstrated complete eradication of disease when treated with 211At-B10-1F5 at a radiation dose that was less than one-third (15 µCi) of the highest dose given to xenograft animals. Tumor progression among untreated control animals in both models was uniformly lethal. After 130 days, no significant renal or hepatic toxicity is observed in the cured animals receiving 15 µCi of 211At-B10-1F5. These findings suggest that in a MRD lymphoma model, where isolated cells and tumor microclusters prevail, α-emitters may be uniquely efficacious.

  18. 25 CFR 39.217 - How are students counted for the purpose of funding residential services?

    Science.gov (United States)

    2010-04-01

    ...) Present for both the after school count and the midnight count at least one night during each week... EDUCATION THE INDIAN SCHOOL EQUALIZATION PROGRAM Administrative Procedures, Student Counts, and... services? For a student to be considered in residence for purposes of this subpart, the school must be...

  19. Advanced Chemical Precipitation Softening. Training Module 2.217.4.77.

    Science.gov (United States)

    McMullen, L. D.

    This document is an instructional module package prepared in objective form for use by an instructor familiar with the operation and maintenance of a chemical precipitation softening system. Included are objectives, instructor guides, student handouts and transparency masters. This is the third level of a three module series. This module considers…

  20. Yeast Interacting Proteins Database: YMR159C, YBR217W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form ...d in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg1

  1. Yeast Interacting Proteins Database: YPL149W, YBR217W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a comp...ophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p... Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated A...olved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation;

  2. 48 CFR 1252.217-73 - Inspection and manner of doing work.

    Science.gov (United States)

    2010-10-01

    ... work in accordance with the contract, any drawings and specifications made a part of the job order, and.... (2) When Navy specifications are specified in the contract, the Contractor shall follow Navy... shall make them available to the Government during performance of the contract and for 90 days after...

  3. 48 CFR 3052.217-92 - Inspection and manner of doing work (USCG).

    Science.gov (United States)

    2010-10-01

    ... accordance with the contract, any drawings and specifications made a part of the job order, and any change or... all workmanship, material, equipment, and articles used in the performance of work under this contract... shall make them available to the Government during performance of the contract and for 90 days after...

  4. SU-E-T-217: Intrinsic Respiratory Gating in Small Animal CT

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Y; Smith, M; Mistry, N [University of Maryland School of Medicine, Baltimore, MD (United States)

    2014-06-01

    Purpose: Preclinical animal models of lung cancer can provide a controlled test-bed for testing dose escalation or function-based-treatment-planning studies. However, to extract lung function, i.e. ventilation, one needs to be able to image the lung at different phases of ventilation (in-hale / ex-hale). Most respiratory-gated imaging using micro-CT involves using an external ventilator and surgical intervention limiting the utility in longitudinal studies. A new intrinsic respiratory retrospective gating method was developed and tested in mice. Methods: A fixed region of interest (ROI) that covers the diaphragm was selected on all projection images to estimate the mean intensity (M). The mean intensity depends on the projection angle and diaphragm position. A 3-point moving average (A) of consecutive M values: Mpre, Mcurrent and Mpost, was calculated to be subtracted from Mcurrent. A fixed threshold was used to enable amplitude based sorting into 4 different phases of respiration. Images at full-inhale and end-exhale phases of respiration were reconstructed using the open source OSCaR. Lung volumes estimated at the 2 phases of respiration were validated against literature values. Results: Intrinsic retrospective gating was accomplished without the use of any external breathing waveform. While projection images were acquired at 360 different angles. Only 138 and 104 projections were used to reconstruct images at full-inhale and end-exhale. This often results in non-uniform under-sampled angular projections leading to some minor streaking artifacts. The calculated expiratory, inspiratory and tidal lung volumes correlated well with the values known from the literature. Conclusion: Our initial result demonstrates an intrinsic gating method that is suitable for flat panel cone beam small animal CT systems. Reduction in streaking artifacts can be accomplished by oversampling the data or using iterative reconstruction methods. This initial experience will enable freebreathing small animal micro-CT imaging to fuel longitudinal studies of lung function.

  5. 18 CFR 2.17 - Price discrimination and anticompetitive effect (price squeeze issue).

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Price discrimination... discrimination and anticompetitive effect (price squeeze issue). To implement compliance with the Supreme Court... interested person may file petitions to intervene alleging price discrimination and anticompetitive...

  6. Subtask 2.17 - CO{sub 2} Storage Efficiency in Deep Saline Formations

    Energy Technology Data Exchange (ETDEWEB)

    Gorecki, Charles; Liu, Guoxiang; Braunberger, Jason; Klenner, Robert; Ayash, Scott; Dotzenrod, Neil; Steadman, Edward; Harju, John

    2014-02-01

    As the field of carbon capture and storage (CCS) continues to advance, and large-scale implementation of geologic carbon dioxide (CO{sub 2}) storage progresses, it will be important to understand the potential of geologic formations to store meaningful amounts of CO{sub 2}. Geologic CO{sub 2} storage in deep saline formations (DSFs) has been suggested as one of the best potential methods for reducing anthropogenic CO{sub 2} emission to the atmosphere, and as such, updated storage resource estimation methods will continue to be an important component for the widespread deployment of CCS around the world. While there have been several methodologies suggested in the literature, most of these methods are based on a volumetric calculation of the pore volume of the DSF multiplied by a storage efficiency term and do not consider the effect of site-specific dynamic factors such as injection rate, injection pattern, timing of injection, pressure interference between injection locations, and overall formation pressure buildup. These volumetric methods may be excellent for comparing the potential between particular formations or basins, but they have not been validated through real-world experience or full-formation injection simulations. Several studies have also suggested that the dynamic components of geologic storage may play the most important role in storing CO{sub 2} in DSFs but until now have not directly compared CO{sub 2} storage resource estimates made with volumetric methodologies to estimates made using dynamic CO{sub 2} storage methodologies. In this study, two DSFs, in geographically separate areas with geologically diverse properties, were evaluated with both volumetric and dynamic CO{sub 2} storage resource estimation methodologies to compare the results and determine the applicability of both approaches. In the end, it was determined that the dynamic CO{sub 2} storage resource potential is timedependent and it asymptotically approaches the volumetric CO{sub 2} storage resource potential over very long periods of time in the two systems that were evaluated. These results indicate that the volumetric assessments can be used as long as the appropriate storage efficiency terms are used and it is understood that it will take many wells over very long periods of time to fully realize the storage potential of a target formation. This subtask was funded through the Energy & Environmental Research Center (EERC)– U.S. Department of Energy (DOE) Joint Program on Research and Development for Fossil Energy-Related Resources Cooperative Agreement No. DE-FC26-08NT43291. Nonfederal funding was provided by the IEA Greenhouse Gas R&D Programme.

  7. 48 CFR 252.217-7005 - Inspection and manner of doing work.

    Science.gov (United States)

    2010-10-01

    ... Shipping, the U.S. Coast Guard, and the Institute of Electrical and Electronic Engineers, in effect at the... accordance with Occupational Safety and Health Administration regulations (29 CFR 1915.14) before any hot... shall at all times keep the site of the work on the vessel free from accumulation of waste material...

  8. Children of Working Mothers, March 1977. Special Labor Force Report 217.

    Science.gov (United States)

    Grossman, Allyson Sherman

    1979-01-01

    This special labor force report, focusing on children of working mothers, summarizes findings from the 1977 annual survey of marital and family characteristics of workers in the population who are 16 years old and over. Data are given on: the numbers of children of various ages with working mothers, the percentages of black and white children…

  9. Q/SdR.04.896-2008 SQR7130A217/Model A Car

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    1.Background As the development of global economy demands an increasingly large quantity of energy,the energy crisis is getting more severe.Auto manufacturers in Japan,America,and Europe have all began to develop hybrid power vehicles or its technology platform since 1990s,so as to save energy.Relied on its THS system which consists of the planet wheel and e-CVT,TOYOTA developed a series of strong hybrid power vehicles,such as Prius,Lexus,Highlander,Camry,etc.Based on its IMA system,HONDA developed a series of mild hybrid power vehicles,such as Insight,Civic,Accord,etc.On the basis of its Belt-driven Starter Generator (BSG) system,French SPA Group developed a series of weak hybrid power vehicles,such as Citroen C3,Citroen C2,Citroen 1007,Citroen 207,etc.In America the research of hybrid power vehicle is being done actively by a group of relevant parties consisting of Department of Transport,Department of Defense,major auto companies and relevant organizations under the leadership of Department of Energy and with the large quantity ofinvestment from GE Motors Co.and CHRYSLER.

  10. Progress of Recycling in the Built Environment Final report of the RILEM Technical Committee 217-PRE

    CERN Document Server

    2013-01-01

    This report is a useful tool for countries starting to recycle aggregates or construction and demolition waste. It contains the latest developments in this field, introduces a completely new approach to the procedure of proportioning concrete mixtures with recycled aggregate, references recent publications, opinions and discrepancies in relation to the durability of recycled concrete, such as freeze-thaw standards, studies of chloride penetration and diffusion, and sulfate attacks, the use of the fine fraction <4mm, quality assurance of concrete recycled aggregate, sustainability and recycling construction waste and global impact assessment of urban renewal based on sustainable recycling strategies for construction and demolition waste. This volume will be of interest to recyclers, researchers and consumers.

  11. 49 CFR 232.217 - Train brake tests conducted using yard air.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Train brake tests conducted using yard air. 232... Train brake tests conducted using yard air. (a) When a train air brake system is tested from a yard air... reduction of brake pipe air pressure at the same, or slower, rate as an engineer's brake valve. (b) The...

  12. 5 CFR 591.217 - In which outlets does OPM collect prices?

    Science.gov (United States)

    2010-01-01

    ... data collection areas, accessibility by road, physical size, advertising, and other characteristics that reflect sales volume. To the extent practical, OPM prices like items in the same types of...

  13. Basic webliography on health promotion and disease prevention - doi:10.5020/18061230.2009.p217

    Directory of Open Access Journals (Sweden)

    Ana Claudia Camargo Gonçalves da Silva

    2012-01-01

    Full Text Available Objectives: To introduce a basic webliography to access highly qualified evidence-based material on health promotion and disease prevention, aiming at the continuing education of health professionals. Methods: By means of Google® browser, applying the descriptors in sequence to progressively refine the search on Internet and key concepts to be learned, all previously defined by the authors themselves, we proceeded a qualitative analyses of the 20 first listed links for each searched issue and the final selection of the most scientifically relevant ones. Results: The 34 selected links are presented in 4 groups: 23 portals, 5 guides and recommendations, 4 scientific journals and 3 blogs that allow free access to health promotion and disease prevention related subjects, such as: concepts; national and international public policies; epidemiology, statistics and health indicators; diseases screening and prophylaxis; counseling for behavior change of health related habits; and interdisciplinary work. Among the selected links 10 (29% are written in English while the others are in Portuguese. Conclusions: The identification of reading materials on health promotion and disease prevention available on Internet, many in Portuguese, allowed us to select relevant scientifically qualified literature and turn it accessible to health professionals, enabling the acquisition of new knowledge or quick update.

  14. 47 CFR 51.217 - Nondiscriminatory access: Telephone numbers, operator services, directory assistance services...

    Science.gov (United States)

    2010-10-01

    ... be provided in a timely fashion. (iii) Format. A LEC shall provide access to its directory assistance... to allow competing providers full use of these services. (d) Branding of operator services...

  15. Session 21.7 - Education Programs Promoting Light Pollution Awareness and IYL2015

    Science.gov (United States)

    Walker, Constance E.

    2016-10-01

    By proclaiming the IYL2015, the United Nations recognized the importance of light and light based technology in the lives of the citizens of the world and for the development of global society on many levels. Light and application of light science and technology are vital for existing and future advances in many scientific areas and culture. Light is a key element in astronomy: as astronomers, it is what we study and makes our science possible, but it is also what threatens our observations when it is set-off from the ground (light pollution). The UN-designated year 2015 represented a magnificent and unique opportunity for the global astronomical community to disseminate these messages and raise the awareness of the importance and preservation of dark skies for heritage and the natural environment. As such, the International Year of Light served as a launching pad for several projects during 2015. Two other projects with equally as impressive programs are highlighted and begin the narrative for this section on public education and outreach programs on light pollution issues and solutions.

  16. Yeast Interacting Proteins Database: YHR171W, YBR217W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available th phosphatidylethanolamine, required steps in autophagosome formation Rows with ... of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required ste...ps in autophagosome formation Rows with this bait as bait (1) Rows with this bait a

  17. Cyclotron production of cesium radionuclides as analogues for francium-221 biodistribution

    Science.gov (United States)

    Finn, R.; McDevitt, M.; Sheh, Y.; Lom, C.; Qiao, J.; Cai, S.; Burnazi, E.; Nacca, A.; Pillarsetty, N.; Jaggi, J.; Scheinberg, D.

    2005-12-01

    In our clinical investigations focussing on improved therapeutic treatment of specific tumors we have concentrated on a targeted therapy approach utilizing designed radiolabeled monoclonal antibodies as the cytotoxic reagent. The physical characteristics of the alpha particle emitting radionuclide bismuth-213 including the short half-life of 45.6 min, has shown promise for the treatment of specific cancers such as leukemias and lymphomas or micrometastatic carcinomas. In an effort to increase the cytocidal effect of the HuM195, a humanized monoclonal antibody carrier to the CD33 antigen expressed on leukemia cells, our focus is directed toward an "internal" nano-generator composed of Ac-225 radionuclide, the parent of the bismuth-213. The actinium-225 radionuclide decays through several short-lived, alpha emitting daughters including francium-221, astatine-217 and bismuth-213. In order to study the biodistribution and the pharmacokinetics of the individual daughter nuclide, francium-221, the cyclotron production and separation of cesium radionuclides, specifically cesium-132, from a natural xenon gas target was undertaken. The choice of cesium as an analogue for francium was predicated upon both elements being in Group 1A alkali metals and cesium radionuclide possesses a sufficient half-life to allow biodistribution studies to be performed. The preliminary experimental results of this investigation are presented.

  18. 10 CFR Appendix C to Part 20 - Quantities 1 of Licensed Material Requiring Labeling

    Science.gov (United States)

    2010-01-01

    ... Polonium-205 1,000 Polonium-207 1,000 Polonium-210 0.1 Astatine-207 100 Astatine-211 10 Radon-220 1 Radon-222 1 Francium-222 100 Francium-223 100 Radium-223 0.1 Radium-224 0.1 Radium-225 0.1 Radium-226...

  19. 50 CFR 226.217 - Critical habitat for the Gulf of Maine Distinct Population Segment of Atlantic Salmon (Salmo salar).

    Science.gov (United States)

    2010-10-01

    ... larval development; (iii) Freshwater spawning and rearing sites with clean gravel in the presence of cool, oxygenated water and diverse substrate to support emergence, territorial development, and feeding...

  20. Ser217Cys mutation in the Ig Ⅱ domain of FGFR3 in a Chinese family with autosomal dominant achondroplasia

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shi-rong; ZHOU Xiao-qing; REN Xiang; WANG Tian-tian; YUAN Ming-xiong; WANG Qing; LIU Jing-yu; LIU Mu-gen

    2007-01-01

    @@ Achondroplasia (ACH) is the most common form of skeletal dysplasia characterized by disproportionately short stature, lumbar lordosis, relative macrocephaly and other skeletal anomalies resulting from a defect in the maturation of the chondrocytes in the growth plate of the cartilage. The combined frequency of the disease has been estimated to be 1 in 15 000 live births.1 ACH is inherited in autosomal dominant fashion with a complete penetrance, more than 80% of affected individuals have de novo mutations associated with increased paternal age.

  1. Recurrent and founder mutations in the Netherlands : mutation p.K217del in troponin T2, causing dilated cardiomyopathy

    NARCIS (Netherlands)

    Otten, E.; Deprez, R. H. Lekanne Dit; Weiss, M. M.; van Slegtenhorst, M.; Joosten, M.; van der Smagt, J. J.; Kerstjens-Frederikse, W. S.; Roofthooft, M. T. R.; Balk, A. H. M. M.; van den Berg, M. P.; van Tintelen, J. P.; Ruiter, J.S.; de Jonge, N.

    2010-01-01

    Background. About 30% of dilated cardiomyopathy (DCM) cases are familial. Mutations are mostly found in the genes encoding lanain A/C, beta-myosin heavy chain and the sarcomeric protein cardiac troponin-T (TNNT2). Mutations in TNNT2 are reported in approximately 3% of DCM patients. The overall pheno

  2. 国外新批准上市的药物新制剂新剂型(217

    Institute of Scientific and Technical Information of China (English)

    黄胜炎

    2016-01-01

    1美国FDA批准盐酸丁丙诺啡含服膜剂上市韩美国FDA批准Endo制药公司和生物释药科学国际公司联合开发的产品(商品名:Belbuca)上市,用于治疗中度至严重慢性疼痛。剂量规格:丁丙诺啡(buprenorphine)75,150,300,450,600,750和900μg/张。每张膜的剂量大小取决于制剂中丁丙诺啡的浓度和膜的表面积。

  3. In vivo emergence of Aspergillus terreus with reduced azole susceptibility and a Cyp51a M217I alteration

    DEFF Research Database (Denmark)

    Arendrup, Maiken C; Jensen, Rasmus; Grif, Katharina;

    2012-01-01

    Azole resistance in Aspergillus terreus isolates was explored. Twenty related (MB) and 6 unrelated A. terreus isolates were included. CYP51A sequencing and RAPD genotyping was performed. Five MB isolates were itraconazole susceptible, whereas the minimum inhibitory concentrations (MICs) for 15 MB...... isolates were elevated (1-2 mg/L). Voriconazole and posaconazole MICs were 0.5-4 and 0.06-0.5 mg/L, respectively, for MB isolates but 0.25-0.5 and...

  4. 41 CFR 101-6.217 - Laws authorizing Federal financial assistance for programs to which this subpart applies.

    Science.gov (United States)

    2010-07-01

    ... distilled spirits, wine, and malt beverages to eleemosynary institutions (26 U.S.C. 5688). (m) Donation of..., preserving and compiling, and publishing of documentary sources significant to the history of the...

  5. SU-E-J-217: Multiparametric MR Imaging of Cranial Tumors On a Dedicated 1.0T MR Simulator Prior to Stereotactic Radiosurgery

    Energy Technology Data Exchange (ETDEWEB)

    Wen, N; Glide-Hurst, C; Liu, M; Hearshen, D; Brown, S; Siddiqui, S; Chetty, I [Henry Ford Health System, Detroit, MI (United States)

    2015-06-15

    Purpose: Quantitative magnetic resonance imaging (MRI) of cranial lesions prior to stereotactic radiosurgery (SRS) may improve treatment planning and provide potential prognostic value. The practicality and logistics of acquiring advanced multiparametric MRI sequences to measure vascular and cellular properties of cerebral tumors are explored on a 1.0 Tesla MR Simulator. Methods: MR simulation was performed immediately following routine CT simulation on a 1T MR Simulator. MR sequences used were in the order they were performed: T2-Weighted Turbo Spin Echo (T2W-TSE), T2 FLAIR, Diffusion-weighted (DWI, b = 0, 800 to generate an apparent diffusion coefficient (ADC) map), 3D T1-Weighted Fast Field Echo (T1W-FFE), Dynamic Contrast Enhanced (DCE) and Post Gadolinium Contrast Enhanced 3D T1W-FFE images. T1 pre-contrast values was generated by acquiring six different flip angles. The arterial input function was derived from arterial pixels in the perfusion images selected manually. The extended Tofts model was used to generate the permeability maps. Routine MRI scans took about 30 minutes to complete; the additional scans added 12 minutes. Results: To date, seven patients with cerebral tumors have been imaged and tumor physiology characterized. For example, on a glioblastoma patient, the volume contoured on T1 Gd images, ADC map and the pharmacokinetic map (Ktrans) were 1.9, 1.4, and 1.5 cc respectively with strong spatial correlation. The mean ADC value of the entire volume was 1141 μm2/s while the value in the white matter was 811 μm2/s. The mean value of Ktrans was 0.02 min-1 in the tumor volume and 0.00 in the normal white matter. Conclusion: Our initial results suggest that multiparametric MRI sequences may provide a more quantitative evaluation of vascular and tumor properties. Implementing functional imaging during MR-SIM may be particularly beneficial in assessing tumor extent, differentiating radiation necrosis from tumor recurrence, and establishing reliable bio-markers for treatment response evaluation. The Department of Radiation Oncology at Henry Ford Health System has research agreement with Varian Medical System and Philips Health Care.

  6. Melhaoui Mohammed, Peste, contagion et martyre. Histoire du fléau en Occident médiéval, Paris, Publisud, 2005, 217 p.

    Directory of Open Access Journals (Sweden)

    Stéphane Barry

    2007-07-01

    Full Text Available En France, à l’exception des études du médecin, historien et démographe Jean-Noël Biraben (1975-1976, peu de travaux existent sur la Peste noire et ses conséquences dans l’Occident musulman médiéval. On comprendra alors tout l’intérêt de l’ouvrage de Mohammed Melhaoui sur ce thème qu’il connaît bien puisqu’il lui a consacré non seulement une thèse de doctorat d’histoire, mais aussi quelques études portant notamment sur la « perception de la peste en pays chrétiens byzantins et musulman » (Co...

  7. PS2-17: Diabetes Social Support Feasibility Pilot Study: Utilizing Mobile Technology and Self-Identified Supporters to Enhance Self-Monitoring of Blood Glucose

    Science.gov (United States)

    Robinson, Brandi; Roblin, Douglas; Hipkens, James; Vupputuri, Suma; McMahon, Kevin

    2010-01-01

    Background and Aims: Self-monitoring of blood glucose (SMBG) is associated with improved glycemic control among patients with type 2 diabetes, however, the practice of daily self-monitoring is not optimal. Telecommunications technology may improve adherence to recommended self-management practices by remotely transmitting automated reminders to motivate patients, and utilizing social networking for peer support. The purpose of this pilot study is to demonstrate the feasibility and usability of mobile technology and the potential added value of social support to improve SMBG frequency and glycemic control among adults with type 2 diabetes. Methods: Adults 25–74 years of age with type 2 DM and an average HbA1c > 8.0% were recruited from Kaiser Permanente Georgia (KPGA) and Oakhurst Medical Center (OMC, a community health clinic) to participate in a 3-month study using wireless technology. Enrollment sessions with presentations on SMBG techniques, use of the wireless technology, and motivational coaching to enhance social support were conducted in November 2009. During the subsequent 3-months, both diabetes patients and their self-selected supporters will receive text messages to their cell phones summarizing a patient’s SMBG frequency and levels. Participants and their supporters will attend a disenrollment session in February 2010 when feasibility and usability will be assessed in focus groups. Results: 6 of 161 eligible diabetes patients at KPGA and 9 of 28 eligible diabetes patients at OMC, and their self-selected supporters, consented to participate. The average age of diabetes patients was 49.3 years. 86.7% (N=13) were African-American; and 33.3% (N=5) were male. Five days after enrollment, 60% (N=9) of patients had connected their wireless transmitters and had current blood glucose data. Follow-up phone calls will be made to ensure that all participants are connected to the wireless technology within 10 days of the enrollment session. Conclusion: Integrating mobile telecommunications technology with chronic disease management may empower patients in their own self-care and ease the burden on health care providers. Our study will evaluate the potential for studying the use of wireless mobile technology in a larger randomized controlled trial and will obtain participant comments on what changes might improve participant compliance.

  8. Hyperspectral surface materials map of quadrangle 3770, Faizabad (217) and Parkhaw (218) quadrangles, Afghanistan, showing iron-bearing minerals and other materials

    Science.gov (United States)

    King, Trude V.V.; Hoefen, Todd M.; Kokaly, Raymond F.; Livo, Keith E.; Giles, Stuart A.; Johnson, Michaela R.

    2013-01-01

    This map shows the spatial distribution of selected iron-bearing minerals and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. This map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Goethite and jarosite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  9. Hyperspectral surface materials map of quadrangle 3770, Faizabad (217) and Parkhaw (218) quadrangles, Afghanistan, showing carbonates, phyllosilicates, sulfates, altered minerals, and other materials

    Science.gov (United States)

    Kokaly, Raymond F.; King, Trude V.V.; Hoefen, Todd M.; Livo, Keith E.; Giles, Stuart A.; Johnson, Michaela R.

    2013-01-01

    This map shows the spatial distribution of selected carbonates, phyllosilicates, sulfates, altered minerals, and other materials derived from analysis of airborne HyMap™ imaging spectrometer (hyperspectral) data of Afghanistan collected in late 2007. The map is one in a series of U.S. Geological Survey/Afghanistan Geological Survey quadrangle maps covering Afghanistan. Flown at an altitude of 50,000 feet (15,240 meters (m)), the HyMap™ imaging spectrometer measured reflected sunlight in 128 channels, covering wavelengths between 0.4 and 2.5 μm. The data were georeferenced, atmospherically corrected and converted to apparent surface reflectance, empirically adjusted using ground-based reflectance measurements, and combined into a mosaic with 23-m pixel spacing. Variations in water vapor and dust content of the atmosphere, in solar angle, and in surface elevation complicated correction; therefore, some classification differences may be present between adjacent flight lines. The reflectance spectrum of each pixel of HyMap™ imaging spectrometer data was compared to the reference materials in a spectral library of minerals, vegetation, water, and other materials. Minerals occurring abundantly at the surface and those having unique spectral features were easily detected and discriminated, while minerals having slightly different compositions but similar spectral features were less easily discriminated; thus, some map classes consist of several minerals having similar spectra, such as “Epidote or chlorite.” A designation of “Not classified” was assigned to the pixel when there was no match with reference spectra.

  10. Post irradiation fatigue tests of type 316 LN stainless steel. Final report for the ITER Task T511, Subtask 1. European Technology Programme Task GB5-T217

    Energy Technology Data Exchange (ETDEWEB)

    Norring, K.; Koenig, M

    2002-01-01

    The main objective of this Subtask was to estimate the corrosion fatigue behaviour of 316L Stainless Steel (SS) and SS/SS joints, and to check among others the influence of irradiation. Joints were produced by solid Hot Isostatic Pressure (HIP) and powder HIP. Conventional material was used for comparison. The specimens were supplied by EFDA and were irradiated to 4 dpa in Dimitrovgrad (Russia). All specimens were tested at 150 deg C in hydrogenated high purity water. Testing was performed with a stepwise decrease in {delta}K keeping K{sub max} constant. The crack growth rates of irradiated as well as unirradiated specimens tested earlier are of the same magnitude, around 2x10{sup -5} mm/cycle at {delta}K= 18 MPa{radical}m. Thus, irradiation does not seem to enhance the fatigue crack growth rate, at least not up to irradiation levels of 4 dpa. But it is worth noting that the exponents in the da/dN versus {delta}K equation, also known as Paris' law, seems to fall within two areas, either around 3.5 or just below 2. Both Powder HIPed and Solid HIPed specimens are found in both groups. The reason for this is not evident. The fracture surfaces of the specimens show typical fatigue appearance.

  11. Compassion and Caring in Nursing Claire Chambers Compassion and Caring in Nursing and Ryder Elaine Radcliffe £29.99 | 217pp 9781846192876 1846192870 [Formula: see text].

    Science.gov (United States)

    2009-09-23

    THE FOCUS of this book is empathy and sensitivity, dignity and respect, listening and responding, diversity and cultural competence, choice and priorities, and empowerment and advocacy. It is engaging and the references are contemporary. The case-study approach embeds the themes in practice. However, I sensed a feeling of professional despair in one study as the emotion evoked was palpable. The 'thoughts for your practice' section enables readers to reflect critically on their practice.

  12. 26 CFR 1.217-2 - Deduction for moving expenses paid or incurred in taxable years beginning after December 31, 1969.

    Science.gov (United States)

    2010-04-01

    ... addition, A detours into Mexico for sightseeing. Because of the stopovers and tour into Mexico, A's travel... a full-time basis as the operator of a motel both before and after the off-season. A taxpayer...

  13. The crystal structure of franckeite, Pb21.7Sn9.3Fe4.0Sb8.1S56.9

    DEFF Research Database (Denmark)

    Makovicky, Emil; Petricek, Vaclav; Dusek, Michal;

    2011-01-01

    The layer-like crystal structure of franckeite from the mine of San José, Bolivia, exhibits a pronounced one-dimensional transversal wave-like modulation and a non-commensurate layer match in two dimensions. It consists of alternating pseudohexagonal (H) layers and pseudotetragonal (Q) slabs...

  14. EFSA CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2013. Scientific Opinion on Flavouring Group Evaluation 217, Revision 1 (FGE.217Rev1). Consideration of genotoxic potential for α,β-Unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: Lactones

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Binderup, Mona-Lise; Lund, Pia;

    the Procedure. Additional data on genotoxicity for the three representative substances, 5-ethyl-3-hydroxy-4-methylfuran-2(5H)-one [FL-no: 10.023], 3,4-dimethyl-5-pentylidenefuran-2(5H)-one [FL-no: 10.042] and furan-2(5H)-one [FL-no: 10.066], have now been provided. Based on the new data, the Panel concluded...... that 5-ethyl-3-hydroxy-4-methylfuran-2(5H)-one [FL-no: 10.023] does not give rise to concern with respect to genotoxicity and can accordingly, together with the structurally related substance, 3-hydroxy-4,5-dimethylfuran-2(5H)-one [FL-no: 10.030] for which it is a representative, be evaluated using...... the Procedure. For 3,4-dimethyl-5-pentylidenefuran-2(5H)-one [FL-no: 10.042] and furan-2(5H)-one [FL-no: 10.066] the concern for genotoxicity could not be ruled out and a combined micronucleus and Comet assay is requested for these two substances, covering the remaining seven substances [FL-no: 10.034, 10...

  15. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity...

  16. Successful radioimmunotherapy of established syngeneic rat colon carcinoma with 211At-mAb

    DEFF Research Database (Denmark)

    Eriksson, Sophie E; Bäck, Tom; Elgström, Erika

    2013-01-01

    Most carcinomas are prone to metastasize despite successful treatment of the primary tumor. One way to address this clinical challenge may be targeted therapy with α-emitting radionuclides such as astatine-211 (211At). Radioimmunotherapy utilizing α-particle emitting radionuclides is considered...... colon carcinoma with tumor diameters of approximately 10 mm....

  17. Methane origin in the Samail ophiolite: Comment on "Modern water/rock reactions in Oman hyperalkaline peridotite aquifers and implications for microbial habitability" [Geochim. Cosmochim. Acta 179 (2016) 217-241

    Science.gov (United States)

    Etiope, Giuseppe

    2017-01-01

    Miller et al. (2016) report a new study of fluids in the peridotites of the Samail ophiolite in Oman related to modern serpentinization (olivine hydration), a process that can provide energy and raw materials for chemosynthetic microbial life. The authors, in particular, report an isotopic composition for methane (CH4) in groundwater near Ibra (up to 1.4 mM) that is unusually 13C-enriched (δ13CCH4 ∼ +2.4 and +3‰ VPDB), and consider the gas origin to be uncertain, i.e., abiotic or microbial, and to be modulated by significant fractionation due to oxidation or diffusion. The purpose of this comment is to clarify and correct a few points concerning the possible origin of the δ13CCH4 values, with the intention to promote a fruitful and constructive debate, considering the interest that there is for serpentinization and the associated formation of various gases.

  18. Reply to "Methane origin in the Samail ophiolite: Comment on 'Modern water/rock reactions in Oman hyperalkaline peridotite aquifers and implications for microbial habitability'" [Geochim. Cosmochim. Acta 179 (2016) 217-241

    Science.gov (United States)

    Miller, Hannah M.; Matter, Jürg M.; Kelemen, Peter; Ellison, Eric T.; Conrad, Mark; Fierer, Noah; Ruchala, Tyler; Tominaga, Masako; Templeton, Alexis S.

    2017-01-01

    We thank Dr. Giuseppe Etiope for his comment and the opportunity to further discuss why we consider the origin of the methane detected in subsurface fluids obtained from a peridotite aquifer in Oman to be enigmatic.

  19. Public Health and Primary Care - Partners in Population Health Griffiths Siân Gillam Stephen Hill Alison Public Health and Primary Care - Partners in Population Health 217 Oxford University Press 9780198508533 0198508530.

    Science.gov (United States)

    2007-10-24

    An interesting book, it seeks to help the reader to understand the complexity of health improvement, health care and health protection - and provides a practical public health toolkit. The first chapter, 'What is public health?', provides an excellent introduction to the subject, with a brief history lesson and connections to recent white papers and relevant government reports.

  20. WITHDRAWN: Corrigendum to "World Association for the Advancement of Veterinary Parasitology (WAAVP): The 50th anniversary in 2013-History, achievements, and future perspectives" [Vet. Parasitol. 195 (2013) 206-217].

    Science.gov (United States)

    Eckert, J

    2014-01-15

    The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.vetpar.2013.12.026. The duplicate article has therefore been withdrawn.

  1. Thermosalinograph data of the Hawaii Ocean Time-series (HOT) program in the North Pacific, 100 Miles North of Oahu, Hawaii for cruises HOT208-217 during 2009 (NCEI Accession 0069501)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  2. Niskin bottle data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 miles north of Oahu, Hawaii for cruises HOT208-217 during 2009 (NCEI Accession 0069177)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  3. CTD data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 miles north of Oahu, Hawaii for cruises HOT208-217 during 2009 (NCEI Accession 0068957)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  4. Mouton Jean-Michel, Le Sinaï médiéval. Un espace stratégique de l’islam, Paris, PUF, 2000, 217 p.

    Directory of Open Access Journals (Sweden)

    Thierry Bianquis

    2011-12-01

    Full Text Available De petit format, agréablement présenté sur un papier de qualité et agrémenté de cartes claires, d’une typographie lisible tout en respectant les règles de transcription scientifique, cet ouvrage est plaisant à manier. La langue précise et légère, les idées s’enchaînant logiquement, le lecteur ne ressent aucun ennui à découvrir la topographie de cette péninsule désertique et à en suivre son histoire entre la conquête arabe en 639 et la conquête ottomane en 1516. En effet, Jean-Michel Mouton, ...

  5. Bénichou-Safar H., Le tophet de Salammbô à Carthage. Essai de reconstitution, Rome, 2004 (Collection de l’École française de Rome ; 342, 217 p.

    Directory of Open Access Journals (Sweden)

    Imed Ben Jerbania

    2006-10-01

    Full Text Available Le tophet de Salammbô à Carthage n’a pas cessé, depuis sa découverte en 1921, de faire l’objet d’une controverse dont on perçoit le reflet dans les différents travaux qui lui ont été consacrés. Il demeure dans ce sens un espace particulièrement intéressant pour l’étude de la mentalité religieuse des Carthaginois. Lieu sacré bénéficiant d’une longévité depuis l’époque archaïque jusqu’à la chute de la métropole punique, ce site présente un échantillonnage remarquablement ample de mobilier, d’in...

  6. Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines

    Science.gov (United States)

    2012-01-01

    in- tractable pain in advanced rheumatoid arthritis ,” Clinical & Experimental Obstetrics & Gynecology, vol. 29, no. 3, pp. 197– 206, 2002. [118] B. C...Katz, “Neuropathic pain in patients with upper-extremity nerve injury,” Physiotherapy Canada, vol. 62, no. 3, pp. 190–201, 2010. Pain Research and

  7. NCBI nr-aa BLAST: CBRC-ACAR-01-0852 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ACAR-01-0852 ref|ZP_01035335.1| hypothetical protein ROS217_14576 [Roseovarius... sp. 217] gb|EAQ26410.1| hypothetical protein ROS217_14576 [Roseovarius sp. 217] ZP_01035335.1 0.003 28% ...

  8. NCBI nr-aa BLAST: CBRC-PABE-26-1117 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PABE-26-1117 ref|ZP_01033920.1| hypothetical protein ROS217_18782 [Roseovarius... sp. 217] gb|EAQ26601.1| hypothetical protein ROS217_18782 [Roseovarius sp. 217] ZP_01033920.1 2.5 28% ...

  9. NCBI nr-aa BLAST: CBRC-MDOM-11-0019 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-11-0019 ref|ZP_01036200.1| hypothetical protein ROS217_04295 [Roseovarius... sp. 217] gb|EAQ25283.1| hypothetical protein ROS217_04295 [Roseovarius sp. 217] ZP_01036200.1 3.2 28% ...

  10. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  11. Sp ectroscopy of Low-lying States in Odd-Z Odd-A Nuclei Beyond Lead

    Institute of Scientific and Technical Information of China (English)

    U Jakobsson; S Juutinen; A Herzan; J Konki; M Leino; M Mallaburn; J Pakarinen; P Papadakis; J Partanen; P Rahkila; M Sandzelius; J Uusitalo; J Saren; C Scholey; J Sorri; S Stolze; K Auranen; H Badran; B Cederwall; D M Cox; T Grahn; P T Greenlees; R Julin

    2016-01-01

    Low-lying states in odd-Z odd-mass nuclei at the proton drip-line beyond lead have recently been studied through fusion-evaporation reactions using a gas-filled recoil separator. Isomeric 1/2+ and 13/2+ states have been observed in odd-mass astatine and francium nuclei. The systematic behaviour of the level energies of these states have been studied and a similarity between the 1/2+ state in astatine and francium has been found. Furthermore, the 13/2+ state has been observed in the francium nuclei with an oblate behaviour suggesting a coupling of the i13/2 proton to the 2p−2h intruder excitation.

  12. Two-component relativistic density-functional calculations of the dimers of the halogens from bromine through element 117 using effective core potential and all-electron methods.

    Science.gov (United States)

    Mitin, Alexander V; van Wüllen, Christoph

    2006-02-14

    A two-component quasirelativistic Hamiltonian based on spin-dependent effective core potentials is used to calculate ionization energies and electron affinities of the heavy halogen atom bromine through the superheavy element 117 (eka-astatine) as well as spectroscopic constants of the homonuclear dimers of these atoms. We describe a two-component Hartree-Fock and density-functional program that treats spin-orbit coupling self-consistently within the orbital optimization procedure. A comparison with results from high-order Douglas-Kroll calculations--for the superheavy systems also with zeroth-order regular approximation and four-component Dirac results--demonstrates the validity of the pseudopotential approximation. The density-functional (but not the Hartree-Fock) results show very satisfactory agreement with theoretical coupled cluster as well as experimental data where available, such that the theoretical results can serve as an estimate for the hitherto unknown properties of astatine, element 117, and their dimers.

  13. NCBI nr-aa BLAST: CBRC-AGAM-07-0041 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available tive (ubiA-2) [Flavobacterium sp. MED217] gb|EAQ50082.1| 4-hydroxybenzoate octaprenyltransferase , putative (ubiA-2) [Leeuwenhoekiella blandensis MED217] ZP_01060587.1 2e-31 33% ...

  14. Gclust Server: 161377 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 161377 DME_CG18543_24660919 Cluster Sequences - 217 mtrm: matrimony CG18543-PA 1 1....er sequences Cluster Sequences Link to related sequences - Sequence length 217 Representative annotation mtrm: matrimony

  15. Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181, 182, 183, 184, 185, 188, 212, 215, 217, 231, 234, 235, 237, 238, 282, 284, 288, 331, 333, 334, 335, 338, 401, 402, 403, and 407, poloxamer 105 benzoate, and poloxamer 182 dibenzoate as used in cosmetics.

    Science.gov (United States)

    Singh-Joy, Subhashni D; McLain, Valerie C

    2008-01-01

    Poloxamers are polyoxyethlyene, polyoxypropylene block polymers. The impurities of commercial grade Poloxamer 188, as an example, include low-molecular-weight substances (aldehydes and both formic and acetic acids), as well as 1,4-dioxane and residual ethylene oxide and propylene oxide. Most Poloxamers function in cosmetics as surfactants, emulsifying agents, cleansing agents, and/or solubilizing agents, and are used in 141 cosmetic products at concentrations from 0.005% to 20%. Poloxamers injected intravenously in animals are rapidly excreted in the urine, with some accumulation in lung, liver, brain, and kidney tissue. In humans, the plasma concentration of Poloxamer 188 (given intravenously) reached a maximum at 1 h, then reached a steady state. Poloxamers generally were ineffective in wound healing, but were effective in reducing postsurgical adhesions in several test systems. Poloxamers can cause hypercholesterolemia and hypertriglyceridemia in animals, but overall, they are relatively nontoxic to animals, with LD(50) values reported from 5 to 34.6 g/kg. Short-term intravenous doses up to 4 g/kg of Poloxamer 108 produced no change in body weights, but did result in diffuse hepatocellular vacuolization, renal tubular dilation in kidneys, and dose-dependent vacuolization of epithelial cells in the proximal convoluted tubules. A short-term inhalation toxicity study of Poloxamer 101 at 97 mg/m(3) identified slight alveolitis after 2 weeks of exposure, which subsided in the 2-week postexposure observation period. A short-term dermal toxicity study of Poloxamer 184 in rabbits at doses up to 1000 mg/kg produced slight erythema and slight intradermal inflammatory response on histological examination, but no dose-dependent body weight, hematology, blood chemistry, or organ weight changes. A 6-month feeding study in rats and dogs of Poloxamer 188 at exposures up to 5% in the diet produced no adverse effects. Likewise, Poloxamer 331 (tested up to 0.5 g/kg day(-1)), Poloxamer 235 (tested up to 1.0 g/kg day(-1)), and Poloxamer 338 (at 0.2 or 1.0 g/kg day(-1)) produced no adverse effects in dogs. Poloxamer 338 (at 5.0 g/kg day(-1)) produced slight transient diarrhea in dogs. Poloxamer 188 at levels up to 7.5% in diet given to rats in a 2-year feeding study produced diarrhea at 5% and 7.5% levels, a small decrease in growth at the 7.5% level, but no change in survival. Doses up to 0.5 mg/kg day(-1) for 2 years using rats produced yellow discoloration of the serum, high serum alkaline phosphatase activity, and elevated serum glutamicpyruvic transaminase and glutamic-oxalacetic transaminase activities. Poloxamers are minimal ocular irritants, but are not dermal irritants or sensitizers in animals. Data on reproductive and developmental toxicity of Poloxamers were not found. An Ames test did not identify any mutagenic activity of Poloxamer 407, with or without metabolic activation. Several studies have suggested anticarcinogenic effects of Poloxamers. Poloxamers appear to increase the sensitivity to anticancer drugs of multidrug-resistant cancer cells. In clinical testing, Poloxamer 188 increased the hydration of feces when used in combination with a bulk laxative treatment. Compared to controls, one study of angioplasty patients receiving Poloxamer 188 found a reduced myocardial infarct size and a reduced incidence of reinfarction, with no evidence of toxicity, but two other studies found no effect. Poloxamer 188 given to patients suffering from sickle cell disease had decreased pain and decreased hospitilization, compared to controls. Clinical tests of dermal irritation and sensitization were uniformly negative. The Cosmetic Ingredient Review (CIR) Expert Panel stressed that the cosmetic industry should continue to use the necessary purification procedures to keep the levels below established limits for ethylene oxide, propylene oxide, and 1,4-dioxane. The Panel did note the absence of reproductive and developmental toxicity data, but, based on molecular weight and solubility, there should be little skin penetration and any penetration of the skin should be slow. Also, the available data demonstrate that Poloxamers that are introduced into the body via routes other than dermal exposure have a rapid clearance from the body, suggesting that there would be no risk of reproductive and/or developmental toxicity. Overall, the available data do not suggest any concern about carcinogenesis. Although there are gaps in knowledge about product use, the overall information available on the types of products in which these ingredients are used, and at what concentration, indicates a pattern of use. Based on these safety test data and the information that the manufacturing process can be controlled to limit unwanted impurities, the Panel concluded that these Poloxamers are safe as used.

  16. Les professions langagieres a l'aube de l'an 2000: Recherches pedagogiques et linguistiques en traduction, redaction et terminologie (The Language Professions at the Dawn of the Year 2000: Pedagogical and Linguistic Research in Translation, Editing and Terminology). Publication B-217.

    Science.gov (United States)

    Guevel, Zelie, Ed.; Clerc, Isabelle, Ed.

    Essays, all in French, address issues in language teacher and translator training. They include: "Les competences linguistiques et discursives du redacteur professionel: un ensemble a circonscrire" ("Linguistic and Discourse Competencies of the Professional Editor: A Unity To Define") (Celine Beaudet); "Les composantes d'un enseignement systemique…

  17. Alpha-decay studies of the new isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At

    CERN Document Server

    Kettunen, H; Grahn, T; Greenlees, P T; Jones, P; Julin, R; Juutinen, S; Keenan, A; Kuusiniemi, P; Leino, M; Leppaenen, A P; Nieminen, P; Pakarinen, J; Rahkila, P; Uusitalo, J

    2003-01-01

    Detailed alpha-decay studies have been performed for the neutron-deficient isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At. The nuclei were produced in fusion-evaporation reactions of sup 5 sup 4 Fe and sup 5 sup 6 Fe ions with a sup 1 sup 4 sup 1 Pr target. The fusion products were separated in-flight using a gas-filled recoil separator and implanted into a position-sensitive silicon detector. The isotopes were identified using position, time and energy correlations between the implants and subsequent alpha-decays. Three alpha-decaying states were identified for sup 1 sup 9 sup 3 At and two for sup 1 sup 9 sup 1 At. The spin and parity of the initial states in the astatine isotopes were deduced based on unhindered alpha-decays to states in the bismuth daughter nuclei. In both astatine isotopes the 1/2 sup + intruder state was determined to be the ground state and a 7/2 sup - state to be the first-excited state. In sup 1 sup 9 sup 3 At the alpha-decay of the 13/2 sup + state was observed in coincidence...

  18. Dicty_cDB: Contig-U14370-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available n 73 Query: 74 ggtattgntgaaactgaattactatcncataatnaatccnatgaaaaagttttnnacnca 133 ||||||||||||||||||||||||||||...|||||||||||||||||||||||||||||||| Sbjct: 74 ggtattgntgaaactgaattactatcncataatnaatccnatgaaaaagttttnnacnca 133 ...||||| Sbjct: 217 tcaaatacaattaaaaaanaagntgntcnaaaaaatgtnagagtaatgatnatttccccn 158 Query: 74 ggtattgntgaaactgaattactatcncataatnaatccna...|||||||||||||||||||||||||||| Sbjct: 157 ggtattgntgaaactgaattactatcncataatnaatccnatgaaaaagttttnnacnca 98 Quer

  19. 78 FR 43850 - Opportunity for Designation in Owensboro, KY; Bloomington, IL; Iowa Falls, IA; Casa Grande, AZ...

    Science.gov (United States)

    2013-07-22

    ... State Route 217; State Route 217 east to Prairie Dog Town Fork of the Red River; Prairie Dog Town Fork of the Red River southeast to the Briscoe County line; the northern Briscoe County line; the northern..., Lake of the Woods, Marshall, Beltrami, Polk, Pennington, Red Lake, and Clearwater Counties. In...

  20. 75 FR 36348 - Opportunity for Designation in the Amarillo, TX; Cairo, IL; and State of North Carolina Areas

    Science.gov (United States)

    2010-06-25

    ... Donley County; the southern Donley and Armstrong County lines west to Prairie Dog Town Fork of the Red River; Prairie Dog Town Fork of the Red River northwest to State Route 217; State Route 217 west to FM... Carolina) official agencies will end on September 30, 2010. In the March 31, 2010, Federal Register (71...

  1. NCBI nr-aa BLAST: CBRC-AGAM-07-0045 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-07-0045 ref|ZP_01061096.1| copper/silver efflux P-type ATPase [Flavobacte...rium sp. MED217] gb|EAQ49147.1| copper/silver efflux P-type ATPase [Leeuwenhoekiella blandensis MED217] ZP_01061096.1 1e-128 60% ...

  2. 26 CFR 1.1232-3A - Inclusion as interest of original issue discount on certain obligations issued after May 27, 1969.

    Science.gov (United States)

    2010-04-01

    ... of the Federal Reserve. See 12 CFR 217.4(d). The stated redemption price at maturity is $13,382.26..., Regulation Q of the Board of Governors of the Federal Reserve System. See 12 CFR 217.4(d). Interest will be... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Inclusion as interest of original issue...

  3. 77 FR 23547 - Taking and Importing Marine Mammals; Taking Marine Mammals Incidental to Columbia River Crossing...

    Science.gov (United States)

    2012-04-19

    ... Columbia River originates on the west slope of the Rocky Mountains in Canada and flows approximately 1,200... Part 217 Taking and Importing Marine Mammals; Taking Marine Mammals Incidental to Columbia River... Administration 50 CFR Part 217 RIN 0648-BB16 Taking and Importing Marine Mammals; Taking Marine...

  4. EST Table: BP117858 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available iquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (Protein effete)...ilar to Ubiquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (Protein effete) [Tribolium castaneum] FS793905 ce-- ...

  5. Genome Sequences of Three Highly Copper-Resistant Salmonella enterica subsp. I Serovar Typhimurium Strains Isolated from Pigs in Denmark

    DEFF Research Database (Denmark)

    Qin, Yanan; Hasman, Henrik; Aarestrup, Frank Møller;

    2014-01-01

    Salmonella typhimurium is the causative agent of typhoid fever, which causes nearly 21.7 million illnesses and 217,000 deaths around the world each year. Here, we describe the draft genome sequences of the Salmonella typhimurium strains S7, S15, and S23, isolated from copper-fed pigs in Denmark...

  6. 75 FR 67719 - Proposed Consent Decree, Clean Air Act Citizen Suit

    Science.gov (United States)

    2010-11-03

    .... Jackson, No. 10-cv-02859-PJH (N.D. Cal.). Plaintiff filed a deadline suit to compel the Administrator to... (ICAPCD) Rules 201, 202 and 217 submitted to the Environmental Protection Agency (EPA) on or about August... deadlines for EPA's action on ICAPCD Rules 201, 202 and 217. DATES: Written comments on the proposed...

  7. Dicty_cDB: Contig-U15308-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ectin 6 mRNA, ... 217 2e-54 A35715( A35715 ;A28580;I52382;A61369;G01810;S54877;S65689) fodrin ... 217 2e-54 ...ens mRNA; cDNA DKFZp686H2... 113 3e-23 A47213( A47213 ) beta-fodrin - human (fragment) &S65762_1(S65762|...

  8. 76 FR 33615 - Energy Priorities and Allocations System Regulations

    Science.gov (United States)

    2011-06-09

    ... priorities and allocations actions in order to maximize domestic energy supplies pursuant to its authority... necessary or appropriate to promote the national defense. Section 217.2 provides an overview of the EPAS... throughout the entire procurement chain. Section 217.36, ``Changes or cancellations of priority ratings...

  9. 75 FR 41405 - Energy Priorities and Allocations System Regulations

    Science.gov (United States)

    2010-07-16

    ... administration of priorities and allocations actions in order to maximize domestic energy supplies pursuant to... promote the national defense. Proposed Sec. 217.2 would provide an overview of the EPAS program. This... supplier throughout the entire procurement chain. Proposed Sec. 217.36, ``Changes or cancellations...

  10. NCBI nr-aa BLAST: CBRC-TTRU-01-1191 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-1191 ref|ZP_01059110.1| transporter, NRAMP family protein [Leeuwenhoek...iella blandensis MED217] gb|EAQ50942.1| transporter, NRAMP family protein [Leeuwenhoekiella blandensis MED217] ZP_01059110.1 0.81 28% ...

  11. AcEST: BP915836 [AcEST

    Lifescience Database Archive (English)

    Full Text Available udouridine synthase OS=Leeuwenhoekiell... 33 5.8 tr|A8L3M4|A8L3M4_FRASN Acyltransferase 3 OS=Frankia sp. (st...9FLAO Pseudouridine synthase OS=Leeuwenhoekiella blandensis MED217 GN=MED217_04192 PE=3 SV=1 Length = 265 Sc

  12. NCBI nr-aa BLAST: CBRC-TTRU-01-0751 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0751 ref|ZP_01059110.1| transporter, NRAMP family protein [Leeuwenhoek...iella blandensis MED217] gb|EAQ50942.1| transporter, NRAMP family protein [Leeuwenhoekiella blandensis MED217] ZP_01059110.1 0.086 28% ...

  13. NCBI nr-aa BLAST: CBRC-TTRU-01-1149 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-1149 ref|ZP_01061727.1| putative transmembrane ion channel [Leeuwenhoe...kiella blandensis MED217] gb|EAQ48690.1| putative transmembrane ion channel [Leeuwenhoekiella blandensis MED217] ZP_01061727.1 0.025 32% ...

  14. NCBI nr-aa BLAST: CBRC-TTRU-01-0513 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0513 ref|ZP_01059110.1| transporter, NRAMP family protein [Leeuwenhoek...iella blandensis MED217] gb|EAQ50942.1| transporter, NRAMP family protein [Leeuwenhoekiella blandensis MED217] ZP_01059110.1 0.15 26% ...

  15. AcEST: BP915861 [AcEST

    Lifescience Database Archive (English)

    Full Text Available LAO Cell division protein ftsZ OS=Leeuwenhoek... 33 7.0 tr|B2VQY7|B2VQY7_PYRTR Predicted protein OS=Pyrenoph...NKTDS 168 >tr|A3XI85|A3XI85_9FLAO Cell division protein ftsZ OS=Leeuwenhoekiella blandensis MED217 GN=MED217

  16. Planck 2015 results: VII. High Frequency Instrument data processing: Time-ordered information and beams

    DEFF Research Database (Denmark)

    Adam, R.; Ade, P. A R; Aghanim, N.;

    2016-01-01

    The Planck High Frequency Instrument (HFI) has observed the full sky at six frequencies (100, 143, 217, 353, 545, and 857 GHz) in intensity and at four frequencies in linear polarization (100, 143, 217, and 353 GHz). In order to obtain sky maps, the time-ordered information (TOI) containing the d...

  17. GETDB: 103857 [GETDB

    Lifescience Database Archive (English)

    Full Text Available (SG) ubiquitous epi, fb, gut no specific pattern - - comment1:A, comment2:17C5 - ...GFP no specific pattern Lethality - Also known as - Original Comments comment1:A, comment2:17C5 Disc (Image)

  18. Biochemical composition of zooplankton from the northern Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Bhat, K.L.; Sreepada, R.A; Ansari, Z.A

    stream_size 7 stream_content_type text/plain stream_name Pak_J_Mar_Sci_2_17.pdf.txt stream_source_info Pak_J_Mar_Sci_2_17.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  19. Benthic harpacticoid copepod community of Saphala salt marsh along the west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Ingole, B.S.; Ansari, Z.A; Parulekar, A

    stream_size 4 stream_content_type text/plain stream_name Indian_J_Mar_Sci_19_217.pdf.txt stream_source_info Indian_J_Mar_Sci_19_217.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  20. Gclust Server: 121213 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 121213 HSA_113426727 Cluster Sequences Related Sequences(20) 217 XP_001131030.1 PRE...DICTED: hypothetical protein ; no annotation 1 1.00e-99 0.0 0.0 0.0 0.0 0.0 12.5 Show 121213 Cluster ID 12121...equences(20) Sequence length 217 Representative annotation XP_001131030.1 PREDICT

  1. 48 CFR 3017.9000 - Clauses (USCG).

    Science.gov (United States)

    2010-10-01

    ... officer may, in whole or in part (such as after incidents), increase the dollar amounts in the clause at (HSAR) 48 CFR 3052.217-95(b)(6) and (c)(1) consistent with contract size, inflation, and other... dollar amounts in the clause at (HSAR) 48 CFR 3052.217-95(b)(6) and (c)(1) consistent with contract...

  2. Regulatory Assistance, Stakeholder Outreach, and Coastal and Marine Spatial Planning Activities in Support of Marine and Hydrokinetic Energy Deployment

    Energy Technology Data Exchange (ETDEWEB)

    Geerlofs, Simon H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Copping, Andrea E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Van Cleve, Frances B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Blake, Kara M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hanna, Luke A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2011-09-01

    This fiscal year 2011 progress report summarizes activities carried out under DOE Water Power Task 2.1.7, Permitting and Planning. Activities under Task 2.1.7 address the concerns of a wide range of stakeholders with an interest in the development of the marine and hydrokinetic (MHK) energy industry, including regulatory and resource management agencies, tribes, nongovernmental organizations, and industry.

  3. NCBI nr-aa BLAST: CBRC-TTRU-01-0165 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0165 ref|XP_710009.1| CTA217 antisense protein [Candida albicans SC531...4] gb|EAK90732.1| CTA217 antisense protein [Candida albicans SC5314] XP_710009.1 2e-04 36% ...

  4. Resonance Capture in Unbalanced Dual-Spin Spacecraft

    Science.gov (United States)

    1994-03-01

    York, 1989. 22. Wittenburg, Jens. "Beitrige zur dynamik von gyrostaten." In Convegno Inter- nazaionale sul Tema: Metodi Valutativi Nella Fisica ...Matematica, Roma, 15-19 dicembre 1972, Problemi Attuali di Scienza e di Cultura , Quaderno N. 217, pages 217-354. Accademia Nazionale dei Lincei, 1975. 23

  5. NCBI nr-aa BLAST: CBRC-SCER-04-0003 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SCER-04-0003 ref|ZP_01035567.1| TRAP dicarboxylate transporter, DctM subunit, putative [Roseo...varius sp. 217] gb|EAQ25732.1| TRAP dicarboxylate transporter, DctM subunit, putative [Roseovarius sp. 217] ZP_01035567.1 5.3 28% ...

  6. NCBI nr-aa BLAST: CBRC-SARA-01-0489 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-0489 ref|ZP_01035526.1| exopolysaccharide biosynthesis domain protein [Roseo...varius sp. 217] gb|EAQ25691.1| exopolysaccharide biosynthesis domain protein [Roseovarius sp. 217] ZP_01035526.1 1.0 26% ...

  7. NCBI nr-aa BLAST: CBRC-DSIM-01-0068 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DSIM-01-0068 ref|ZP_01038050.1| Nitric oxide reductase large subunit, cytochrome b [Roseo...varius sp. 217] gb|EAQ23442.1| Nitric oxide reductase large subunit, cytochrome b [Roseovarius sp. 217] ZP_01038050.1 2.6 29% ...

  8. NCBI nr-aa BLAST: CBRC-SARA-01-0832 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-0832 ref|ZP_01035526.1| exopolysaccharide biosynthesis domain protein [Roseo...varius sp. 217] gb|EAQ25691.1| exopolysaccharide biosynthesis domain protein [Roseovarius sp. 217] ZP_01035526.1 1.0 26% ...

  9. Is electronegativity a useful descriptor for the pseudo-alkali metal NH4?

    Science.gov (United States)

    Whiteside, Alexander; Xantheas, Sotiris S; Gutowski, Maciej

    2011-11-18

    Molecular ions in the form of "pseudo-atoms" are common structural motifs in chemistry, with properties that are transferrable between different compounds. We have determined one such property--the electronegativity--for the "pseudo-alkali metal" ammonium (NH(4)), and evaluated its reliability as a descriptor versus the electronegativities of the alkali metals. The computed properties of ammonium's binary complexes with astatine and of selected borohydrides confirm the similarity of NH(4) to the alkali metal atoms, although the electronegativity of NH(4) is relatively large in comparison to its cationic radius. We have paid particular attention to the molecular properties of ammonium (angular anisotropy, geometric relaxation and reactivity), which can cause deviations from the behaviour expected of a conceptual "true alkali metal" with this electronegativity. These deviations allow for the discrimination of effects associated with the molecular nature of NH(4).

  10. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

    2013-01-01

    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  11. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: bruce.marsh@cern.ch [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others

    2013-12-15

    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  12. Adjunctive levetiracetam in children, adolescents, and adults with primary generalized seizures: Open-label, noncomparative, multicenter, long-term follow-up study.

    LENUS (Irish Health Repository)

    Delanty, Norman

    2012-02-01

    Purpose: To evaluate the long-term efficacy and tolerability of adjunctive levetiracetam (LEV) in patients with uncontrolled idiopathic generalized epilepsy (IGE). Methods: This phase III, open-label, long-term, follow-up study (N167; NCT00150748) enrolled patients (4 to <65 years) with primary generalized seizures (tonic-clonic, myoclonic, absence). Patients received adjunctive LEV at individualized doses (1,000-4,000 mg\\/day; 20-80 mg\\/kg\\/day for children\\/adolescents weighing <50 kg). Efficacy results are reported for all seizure types [intention-to-treat (ITT) population, N = 217] and subpopulations with tonic-clonic (n = 152), myoclonic (n = 121), and\\/or absence (n = 70) seizures at baseline. Key Findings: One hundred twenty-five (57.6%) of 217 patients were still receiving treatment at the end of the study. Mean (standard deviation, SD) LEV dose was 2,917.5 (562.9) mg\\/day. Median (Q1-Q3) exposure to LEV was 2.1 (1.5-2.8) years, and the maximum duration was 4.6 years. Most patients were taking one (124\\/217, 57.1%) or >\\/=2 (92\\/217, 42.4%) concomitant antiepileptic drugs (AEDs). Seizure freedom of >\\/=6 months (all seizure types; primary efficacy end point) was achieved by 122 (56.2%) of 217 patients, and 49 (22.6%) of 217 patients had complete seizure freedom. Seizure freedom of >\\/=6 months from tonic-clonic, myoclonic, and absence seizures was achieved by 95 (62.5%) of 152, 75 (62.0%) of 121, and 44 (62.9%) of 70 patients, respectively. Mean (SD) maximum seizure freedom duration was 371.7 (352.4) days. At least one treatment-emergent adverse event (TEAE) was reported by 165 (76%) of 217 patients; most TEAEs were mild\\/moderate in severity, with no indication of an increased incidence over time. Seventeen (7.8%) of 217 patients discontinued medication because of TEAEs. The most common psychiatric TEAEs were depression (16\\/217, 7.4%), insomnia (9\\/217, 4.1%), nervousness (8\\/217, 3.7%), and anxiety (7\\/217, 3.2%). Significance: Adjunctive

  13. Ribozyme对癌基因ki-rasG12V mRNA的剪切及其特异性%Cleavage of Oncogene ki-rasG12V mRNA by Ribozyme and It' s Specificity

    Institute of Scientific and Technical Information of China (English)

    吴国祥; 方裕强; 许国铭; 李兆申; 陆德如

    2000-01-01

    目的:设计切割ki-rasG12vmRNA的特异性ribozyme(Rz217),明确其对癌基因ki-rasG12VmRNA的细胞内外切割活性,为以ki-rasG12VmRNA为特异性靶分子的基因治疗及癌基因ki-ras的功能研究提拱一种新的途径。方法:依Symons总结的"锤头结构"原理,设计一种能特异性切割ki-rasG12VmRNA的ribozyme,利用DNA重组技术构建ki-rasG12V外显子1和ri-bozyme Rz217的体外转录质粒及ribozyme Rz217的真核表达质粒,体外转录获得ribozyme Rz217及ki-rasG12V外显子1 mRNA,在含Mg2+溶液中ribozyme Rz217对其靶RNA分子进行切割。以RT-PCR对转染ribozyme Rz217真核表达质粒的细胞ki-rasG12VmRNA进行半定量分析。结果:ki-rasG12V外显子1体外转录mRNA分子,能被ribozyme Rz217定点切割而野生型ki-ras外显子1体外转录mRNA则不被切割;转染ribozyme Rz217的胰癌细胞ki-rasG12VmRNA含量减少,而转染ribozyme Re217的肝癌细胞其内源性ki-ras mRNA含量无明显变化。结论:ribozyme Rz217无论在细胞内外均能剪切突变型ki-ras mRNA(G12V)而且其切割作用为突变型ki-rasG12VmRNA特异性的。%Objective: To design and confirm the cleavage activity of ribozyme Rz217 to oncogene ki-rasG12V messenger RNA and search for a new method for gene therapy targeting oncogene ki-ras. Methods: According to Symon' s principle,design an ribozyme specific for ki-rasc12v mRNA, both the constructs for transcription in vitro of ribozyme Rz217 and ki-ras exonl and the mammalian expression constructs of ribozyme Rz217 were constructed by DNA recombinant technique,ribozyme Rz217 and ki-ras exonl mRNA was obtained by transcription in vitro with T7 and SP6 RNA polymerase. Pancre atic carcinoma cell line PaTu8988 and human hepatocellular carcinomacell line BEL7404 were transfected with Rz217 mammalian expression constructs and the level of endogenous ki-rasG12V mRNA or ki-ras mRNA was determined by semiquantitative RT-PCR. Results: Not only in vitro

  14. 76 FR 61956 - Endangered and Threatened Wildlife and Plants; Endangered Status for the Ozark Hellbender Salamander

    Science.gov (United States)

    2011-10-06

    ..., including Beaver, Table Rock, Bull Shoals, and Norfork Reservoirs. North Fork White River--The North Fork....8 to 21.7 in (172 to 551 millimeters (mm)), indicating that reproduction was occurring in...

  15. Gclust Server: 95461 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available ter sequences Cluster Sequences Link to related sequences Related Sequences(217) Sequence length 899 Representative...1 Clustering threshold 1.00e-99 Plants and algae (7species) (%) 0.0 Other Bikonts (Chromalveolata, Excavata)

  16. 18 CFR 157.207 - General reporting requirements.

    Science.gov (United States)

    2010-04-01

    ... CONVENIENCE AND NECESSITY AND FOR ORDERS PERMITTING AND APPROVING ABANDONMENT UNDER SECTION 7 OF THE NATURAL... specified in § 157.217(b); (g) For each change in customer name authorized under § 157.218, the...

  17. Thermophysical and Electronic Properties Information Analysis Center (TEPIAC): A Continuing Systematic Program on Data Tables of Thermophysical and Electronic Properties of Materials.

    Science.gov (United States)

    1980-03-01

    215 REFERENCES ---------------------------------------------------------------------------- 217 80 CHAPTER 8 - SEISMIC WAVE VLILOCITY 8.0...Research Lab. U.S. Army Missile Command West Lafayette, IN Redstone Arsenal Huntsville, AL Westinghouse Hanford Co. Richland, WA U.S. Army Prod

  18. EST Table: FS879118 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available milar to Ubiquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (Protein effet...se) (Ubiquitin carrier protein) (Protein effete) [Tribolium castaneum] FS793905 ftes ...

  19. EST Table: CK514954 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available ar to Ubiquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (Protein effet... (Ubiquitin carrier protein) (Protein effete) [Tribolium castaneum] FS793905 swj ...

  20. EST Table: CK544577 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available ar to Ubiquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiquitin carrier protein) (Protein effet... (Ubiquitin carrier protein) (Protein effete) [Tribolium castaneum] FS793905 swh ...

  1. 78 FR 5424 - Applications for New Awards; Indian Education-Professional Development Grants Program

    Science.gov (United States)

    2013-01-25

    ... 1978 (25 U.S.C. 1801 et seq.), and Dine College (formerly Navajo Community College), authorized in the... 34 CFR 75.217(d)(3), the past performance of the applicant in carrying out a previous award, such...

  2. 77 FR 75420 - Applications for New Awards; Indian Education-Demonstration Grants for Indian Children

    Science.gov (United States)

    2012-12-20

    ... 1978 (25 U.S.C. 1801 et seq.), and Dine College (formerly Navajo Community College) authorized in the... 34 CFR 75.217(d)(3), the past performance of the applicant in carrying out a previous award, such...

  3. 75 FR 28019 - Resmethrin; Notice of Receipt of Requests to Voluntarily Cancel Certain Pesticide Registrations

    Science.gov (United States)

    2010-05-19

    ..., recreational, and residential areas to control flying and crawling insects. All remaining resmethrin end use... reproduction 2.1.7 Hershberger (rat) 2.1.8 Female Pubertal (rat) 2.1.9 Male pubertal (rat)...

  4. Field Plot and Observation Points for Dinosaur National Monument Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — This point file displays the 727 vegetation plots and 217 observation points visited in 2002, 2003 and 2004 as part of the vegetation mapping project. Plots and...

  5. La violencia, el Estado y las clases sociales

    Directory of Open Access Journals (Sweden)

    Gonzalo Sánchez Gómez

    2011-12-01

    Full Text Available Violencia, Conflicto y Politica en Colombia,Paul Oquist. Ed. Instituto de Estudios Colombianos Biblioteca Banco Popular; Bogota, 1978; 339 pags. / Violencia y Desarrollo, Darlo Fajardo. Fondo Editorial Suramerica, Bogota, 1979; 217 paga.

  6. Data of evolutionary structure change: 1GCVA-1YGDD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1GCVA-1YGDD 1GCV 1YGD A D -AFTACEKQTIGKIAQVLAKSPEAYGAECLARLFVTHPG...R MHLTPEEKSAVTALWGKV--NVDEVGGEALGRLLVVYPETQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSEL... 217 ALA CA 203 LYS CA 239 1YGD D 1YGDD FGDLSTPDAVMGNPK THR CA 284 1YGD D 1YGD

  7. Adrenal Insufficiency and Addison's Disease

    Science.gov (United States)

    ... in Endocrinology, Diabetes and Obesity. 2010;(3):217–223. Clinical Trials The National Institute of Diabetes and ... la salud en español Health Statistics Healthy Moments Radio Broadcast Clinical Trials For Health Care Professionals Community ...

  8. AcEST: BP918906 [AcEST

    Lifescience Database Archive (English)

    Full Text Available LVKLMDRSGPVIDQLSNEVASETLHACCP 390 Query: 217 LLRQQKYFEICFAWIQQVADLVVS---DGMDFSENVKKELLLSLQE-RVATSMIADSSGT 50...ANELLHTVAH 218 W+ W + ++ DM+SA++EVLST D +LV+LM R+GPV DQL++ A+E LH Sbjct: 331 WTSWTNAMDAFSVGDMDSAFSEVLSTGDDFL

  9. Drug: D00251 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 217.2853 D00251.gif Antihypertensive; Enzyme inhibitor [angiotensin-converting] Therapeutic category: 2144 ...category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 21 Cardiovascular agents 214 Antihypertensive

  10. Drug: D03328 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D03328 Drug Carperitide (genetical recombination) (JAN); Carperitide (USAN/INN); Ha...l organs 21 Cardiovascular agents 217 Vasodilators 2179 Others D03328 Carperitide (genetical recombination)

  11. 47 CFR 80.385 - Frequencies for automated systems.

    Science.gov (United States)

    2010-10-01

    ... the United States Navy's SPASUR radar system (216.88-217.08 MHz) or to TV reception within the Grade B... Commission on a case-by-case basis upon submission of a technical analysis indicating that at least 18...

  12. Vsjak telefon prinossit dohhod / Viktoria Jürmann

    Index Scriptorium Estoniae

    Jürmann, Viktoria

    2007-01-01

    Kommunikatsiooniettevõtte Eesti Telekom puhaskasum esimesel poolaastal oli 548 miljonit krooni, mis on 21,7 % suurem võrreldes eelmise aasta sama perioodiga, investeeringud on mullusega võrreldes vähenenud

  13. Teadlasena poliitikas - võimalused ja piirid = Als Wissenschaftler in der Politik - Chancen und Grenzen / Eiki Berg

    Index Scriptorium Estoniae

    Berg, Eiki, 1970-

    2005-01-01

    Autori hinnangul lasub teadlasel poliitikas suurem vastutus kui mistahes valdkonna esindajal, sest teaduslikult argumenteeritud poliitilised otsused on teadmiste jõu ja poliitilise võimu sümbioos. Vt. ka kommentaare lk. 217-222,467-472

  14. 78 FR 31519 - Endangered Species; File No. 13543

    Science.gov (United States)

    2013-05-24

    ...Notice is hereby given that South Carolina Department of Natural Resources [Responsible Party: Robert Boyles], 217 Ft. Johnson Rd., Charleston, SC 29412, has been issued a modification to scientific research Permit No....

  15. BIOMASS, SPECIES IDENTIFICATION, TAXONOMIC CODE, SPECIES IDENTIFICATION - LIFE STAGE and species abundance tows data collected in the Gulf of Alaska on the ALPHA HELIX and WECOMA cruises HX201, HX203 and others as part of the NEP project from 1997-10-10 to 2004-10-07 (NODC Accession 0113896)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0113896 includes tows and biological data collected aboard the ALPHA HELIX and WECOMA during cruises HX201, HX203, HX205, HX208, HX211, HX215, HX217,...

  16. 76 FR 79064 - New Animal Drugs; Change of Sponsor; Zinc Gluconate

    Science.gov (United States)

    2011-12-21

    ... new animal drug application (NADA) for zinc gluconate injectable solution from Technology Transfer... it has transferred ownership of, and all rights and interest in, NADA 141-217 for NEUTERSOL...

  17. 78 FR 9771 - Federal Highway Administration

    Science.gov (United States)

    2013-02-11

    ... Federal Highway Administration Notice of Final Federal Agency Action on Proposed Transportation Project in Illinois and Indiana AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of limitation on..., Federal Highway Administration, 3250 Executive Park Drive, Springfield, Illinois 62703, Phone: (217)...

  18. Reference: IDRSZMFER1 [PLACE

    Lifescience Database Archive (English)

    Full Text Available tial involvement of the IDRS cis-element in the developmental and environmental regulation of the AtFer1 ferritin gene from Arabidopsis. Planta. 217: 709-716 (2003) PubMed: 12728319 ...

  19. A Preliminary Study of Reducing the Cost of Blast Shelter for Critical Workers

    Science.gov (United States)

    1983-08-01

    23 2.1.6 Luscher Study ..... ................. .... 28 2.1.7 Krupka Study ..... ................. .... 29 2.1.9 Haaland Study...a more reasonable cost/space number had been reported. 2.1.6 Ulrich Luscher - Behavior of Flexible Underground Cylinders, 1965 This study ( Luscher ...information about the utilization of corrugated culverts as blast shelters and modes of hardening. No cost analyses were discussed by Luscher . 2.1.7 R. A

  20. AcEST: BP917913 [AcEST

    Lifescience Database Archive (English)

    Full Text Available M88|A3XM88_9FLAO Acetyltransferase OS=Leeuwenhoekiella bla... 33 5.4 tr|Q9U0Z7|Q9U0Z7_LEIMA Hypothetical tra...88|A3XM88_9FLAO Acetyltransferase OS=Leeuwenhoekiella blandensis MED217 GN=MED217_07986 PE=4 SV=1 Length = 1

  1. Experiment list: SRX100401 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available d of PCR and an additional 15-cycle round of PCR after gel size selection (Myers) || controlid=SL217,SL218 |...al 15-cycle round of PCR after gel size selection (Myers) || replicate=1,2 || softwareversion=MACS || antibo...ent or protocol applies || protocol=PCR2x || protocol description=2-cycles of PCR (Myers) || controlid=SL217

  2. Modeling Sorption and Degradation of 17β-Estradiol-17-Sulfate in Agricultural Soils

    Science.gov (United States)

    Bai, X.; Casey, F. X.; Hakk, H.; Shrestha, S. L.; DeSutter, T.; Khan, E.; Oduor, P. G.

    2011-12-01

    The natural steroid hormone, 17β-estradiol (E2), can be an endocrine disruptor at part-per trillion levels. Laboratory studies indicate a low potential for E2 persistence and mobility in the environment; however, field studies consistently indicate the presence of E2 and its primary metabolite, estrone, at levels sufficiently high to impact water quality. To facilitate urine excretion, animals may release E2 as a sulfated conjugate, which would have a higher aqueous solubility than the parent compound. We hypothesize that E2 conjugates contribute to the detection of free estrogens in the environment. The objective of this study was to determine the sorption, degradation, and mobility of a model conjugate, 17β-estradiol-17-sulfate (E2-17S), in agricultural soils. Radiolabeled E2-17S ([14C]E2-17S) was chemically synthesized in a three-step process, and then batch experiments were conducted in natural and sterile soils. Additionally, soil organic carbon (OC) was varied (1.29 and 0.26%) to investigate its effect on the fate of [14C]E2-17S. Liquid scintillation counting (LSC) was used in concert with high performance liquid chromatography (HPLC) to detect and quantitate parent compound and metabolites of E2-17S in the aqueous and bound phases. Residual soil was combusted to determine non-extractable levels of 14C. The E2-17S was relatively stable in the aqueous phase for natural and sterile soils. Mono- and di- hydroxyl E2-17S were detected as metabolites of E2-17S in the aqueous phase above both sterile and natural soil. Deconjugation to form E2 was not observed in aqueous phase; however, E2 and estrone were extracted from both natural and sterile soils. A conceptual model was developed to simulate and identify the fate and transport processes of E2-17S. Organic carbon was found to be an important factor affecting the sorption and degradation of E2-17S in soils.

  3. Immunization against Egyptian Schistosoma mansoni infection by multivalent DNA vaccine

    Institute of Scientific and Technical Information of China (English)

    Mahmoud H Romeih; Hanem M Hassan; Tarek S Abou Shousha; Mohamed A Saber

    2008-01-01

    The development of multivalent vaccines consisting of several antigens is a novel approach to creating broad-range protection against different parasite strains and parasite life cycle stages. We have previously confirmed that the schistosome Sm21.7 and SmFimbrin (SmFim) proteins could induce protection in mice. Therefore, this study aimed to construct the multivalent DNA vaccine Sm21.7-SmFim/pBudCE4.1 and evaluate its immune efficacy. The open reading frames of two Schistosoma mansoni genes, Sm21.7 and SmFim, were inserted into the eukaryotic expression plasmid pBudCE4.1 designed for the independent expression of two genes in mammalian cells. To evaluate the in vitro expression of the multivalent Sm21.7-SmFim/pBudCE4.1 DNA vaccine and its immunological effect in mice, the recombinant plasmid Sm21.7-SmFim/pBudCE4.1 was used to transfect 293T cells, and the expression of mRNA and proteins was examined using reverse transcription-polymerase chain reaction and Western blot analysis. Then the ability of Sm21.7.SmFim/pBudCE4.1 to protect against S. mansoni challenge infections was analyzed according to worm burden and egg reduction rates after vaccination of mice. Vaccinated mice showed a significant level of protection (56%), and a decrease in the number and size, and change in the cellular profile, of granulomas. Egg reduction in liver and intestine was 41.53% and 55.63%,respectively, as determined relative to mice that received the empty vector only. In addition to reductions in worm viability,worm fecundity and egg hatching ability were observed following challenge infection in the immunized group.Results showed that Sm21.7-SmFim/pBudCE4.1 could express Sm 21.7 and SmFim mRN A and proteins. Enzyme-linked immunosorbent assay and Western blot analysis indicated that immunized mice generated specific immunoglobulin G against Sm21.7-SmFim/pBudCE4.1. These results suggest that vaccination with multivalent S. mansoni DNA vaccine (SmFim-Sm21.7/pBudCE4.1) not only induces a

  4. Development of Reagents for Application of At-211 to Targeted Radionuclide Therapy of Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott

    2011-12-23

    This grant covered only a period of 4 months as the major portion of the award was returned to DOE due to an award of funding from NIH that covered the same research objectives. A letter regarding the termination of the research is attached as the last page of the Final Report. The research conducted was limited due to the short period of this grant, but the results obtained in that period are outlined in the Final Report. The studies addressed in the research effort were directed at a problem that is of critical importance to the in vivo application of the alpha-particle emitting radionuclide At-211. That problem, low in vivo stability of many astatinated molecules, severely limits the use of At-211 in therapeutic applications. The advances sought in the studies were expected to expand the types of biomolecules that can be used as carriers of At-211, and provide improved in vivo targeting of the radiation dose compared with the dose delivered to normal tissue.

  5. Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with {sup 211}At-EGF

    Energy Technology Data Exchange (ETDEWEB)

    Sundberg, Aasa Liljegren; Orlova, Anna; Gedda, Lars; Tolmachev, Vladimir; Carlsson, Joergen [Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala (Sweden); Almqvist, Ylva [Division of Radiology, Uppsala University, Uppsala (Sweden); Blomquist, Erik [Division of Oncology, Uppsala University, Uppsala (Sweden); Jensen, Holger J. [Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Rigshospitalet, Copenhagen (Denmark)

    2003-10-01

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib ['Iressa' (trademark of the AstraZeneca group of companies), ZD1839] increases the cellular uptake of radiolabelled epidermal growth factor (EGF). We investigated gefitinib treatment combined with astatine-211 EGF targeting in vitro using two cell lines expressing high levels of EGFR: A431 (sensitive to gefitinib) and U343MGaCl2:1 (resistant to gefitinib). In both cell lines, the uptake of {sup 211}At-EGF was markedly increased by concomitant treatment with gefitinib. Survival was investigated using both a clonogenic survival assay and a cell growth assay. Combined gefitinib and {sup 211}At-EGF treatment reduced the survival of U343 cells 3.5-fold compared with {sup 211}At-EGF alone. In A431 cells, {sup 211}At-EGF treatment resulted in very low survival, but combined treatment with gefitinib increased the survival by about 20-fold. These results indicate that combined treatment with gefitinib might increase the effect of ligand-mediated radionuclide therapy in gefitinib-resistant tumours and decrease the effect of such therapy in gefitinib-sensitive tumours. (orig.)

  6. Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Nestor, Marika, E-mail: marika.nestor@bms.uu.s [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden); Sundstroem, Magnus [Unit of Molecular Pathology, Department of Genetics and Pathology, Uppsala University (Sweden); Anniko, Matti [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Tolmachev, Vladimir [Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden)

    2011-01-15

    Aim: The monoclonal antibody cetuximab, targeting the epidermal growth factor receptor (EGFR), is a promising molecular targeting agent to be used in combination with radiation for anticancer therapy. In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed. Methods: SCC cell lines were characterized and treated with cetuximab in combination with anti-CD44v6 RIT using the astatinated chimeric monoclonal antibody U36 ({sup 211}At-cMAb U36). Effects on {sup 211}At-cMAb U36 uptake, internalization and cell proliferation were then assessed in SCC cells. Results: Cetuximab in combination with {sup 211}At-cMAb U36 mediated increased growth inhibition compared to RIT or cetuximab alone in two cell lines. However, cetuximab also mediated radioprotective effects compared to RIT alone in two cell lines. The radioprotective effects occurred in the cell lines in which cetuximab clearly inhibited cell growth during radiation exposure. Cetuximab treatment also influenced {sup 211}At-cMAb-U36 uptake and internalization, suggesting interactions between CD44v6 and EGFR. Conclusions: Results from this study demonstrate the vast importance of further clarifying the mechanisms of cetuximab and radiation response, and the relationship between EGFR and suitable RIT targets. This is important not only in order to avoid potential radioprotective effects, but also in order to find and utilize potential synergistic effects from these combinations.

  7. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  8. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  9. Metalloids, soil chemistry and the environment.

    Science.gov (United States)

    Lombi, Enzo; Holm, Peter E

    2010-01-01

    This chapter reviews physical chemical properties, origin and use ofmetalloids and their relevance in the environment. The elements boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), tellurium (Te), polonium (Po) and astatine (At) are considered metalloids. Metalloids conduct heat and electricity intermediate between nonmetals and metals and they generally form oxides. The natural abundance ofmetalloids varies from Si being the second most common element in the Earth's crust to At as the rarest of natural elements on Earth. The metalloid elements Ge, Te, Po and At are normally present in trace or ultratrace levels in the environment and as such are not considered of relevance in terms of environmental health. The environmental geochemical processes, factors and parameters controlling the partitioning and the speciation of B, Si, As and Sb are reviewed in relation to the bioavailability of these metalloids. Approaches based on the hypothesis that metal toxicity is related to both the metal-ligand complexation processes and the metal interactions with competing cations at the cell surface (biotic ligand) have so far not been successful for assessing metalloid bioavailability. The chapter concludes that our understanding of metalloids toxicity will improve in the future if, in addition to the points discussed above, surface membrane potentials are considered. This should represent a robust approach to the prediction of metalloid toxicity.

  10. SPECT assay of radiolabeled monoclonal antibodies. Progress report, September 1, 1992--August 24, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1993-08-20

    The overall goal of this project is to improve the effectiveness of single photon emission computed tomography (SPECT) to image and quantify radiolabeled monoclonal antibodies. During the past year, we have made significant progress toward this goal, and this report summarizes that work. Our efforts have been mainly directed along three fronts. First, we have developed and tested new reconstruction methods including three-dimensional iterative algorithms that model non-uniform attenuation and distance-dependent detector response. Both fan beam and parallel beam collimator geometries have been modeled and novel ways of improving the efficiency of the computationally intensive methods have been introduced. Second, an ultra-high resolution, small field-of-view pinhole collimator has been constructed and evaluated. Reconstructed spatial resolution of 1 to 3 mm (FWHM) has been achieved in phantom scans with a useful field-of-view of 9 to 10 cm. Finally, we have investigated the ability of SPECT to image and quantify astatine-211 distributions. Reconstructed images of phantom data demonstrated quantitative accuracy to within 10% with proper attenuation and scatter compensation.

  11. Glomerular filtration rate after alpha-radioimmunotherapy with 211At-MX35-F(ab')2: a long-term study of renal function in nude mice

    DEFF Research Database (Denmark)

    Back, T.; Haraldsson, B.; Hultborn, R;

    2009-01-01

    and animals bearing subcutaneous xenografts of the human ovarian cancer cell line, OVCAR-3, were used. The animals received approximately 0.4, 0.8, or 1.2 MBq in one, two, or three fractions. The mean absorbed doses to the kidneys ranged from 1.5 to 15 Gy. The renal function was studied by serial GFR...... of the glomerular filtration rate (GFR). The renal toxicity was evaluated at levels close to the dose limit for the bone marrow and well within the range for therapeutic efficacy on tumors. Astatinated MX35-F(ab')(2) monoclonal antibodies were administered intravenously to nude mice. Both non-tumor-bearing animals...... manifested late. Examination of the kidney sections showed histologic changes that were overall subdued. Following alpha-RIT with (211)At-MX35-F(ab')(2) at levels close to the dose limit of severe myelotoxicity, the effects found on renal function were relatively small, with only minor to moderate reductions...

  12. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  13. Studies of Stable Octupole Deformations in the Radium Region

    CERN Multimedia

    2002-01-01

    The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

  14. Alpha particle emitters in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, D.R.

    1989-09-01

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ({sup 211}At) and natural bismuth-212 ({sup 212}Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ({sup 223}Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

  15. Increased diuron resistance in the joint expression of mutations located at the DIU2, DIU3 and DIU4 loci of Saccharomyces cerevisiae.

    Science.gov (United States)

    Meunier, B; Colson, A M

    1989-02-01

    In Saccharomyces cerevisiae, diuron blocks the respiratory pathway at the level of the bc1 complex. Two mitochondrially inherited loci, DIU1 and DIU2, located in the cytochrome b gene, and two nuclearly inherited loci, DIU3 and DIU4, have previously been identified. The present work genetically characterizes two double mutants. One mutant, Diu-217, carries two nuclearly inherited mutations, diu3-217a and diu-217b; the second mutant, Diu-783, carries the previously described nuclear mutation diu3-783 and a mitochondrial mutation diu2-783. Each mutation, independent of its location, exhibits a weak diuron resistance. The joint expression of two or three mutations leads to a cumulative or a cooperative enhanced diuron-resistant phenotype.

  16. Cross-categorization of legal concepts across boundaries of legal systems: in consideration of inferential links

    DEFF Research Database (Denmark)

    Glückstad, Fumiko Kano; Herlau, Tue; Schmidt, Mikkel Nørgaard

    2014-01-01

    This work contrasts Giovanni Sartor’s view of inferential semantics of legal concepts (Sartor in Artif Intell Law 17:217–251, 2009) with a probabilistic model of theory formation (Kemp et al. in Cognition 114:165–196, 2010). The work further explores possibilities of implementing Kemp’s probabili......This work contrasts Giovanni Sartor’s view of inferential semantics of legal concepts (Sartor in Artif Intell Law 17:217–251, 2009) with a probabilistic model of theory formation (Kemp et al. in Cognition 114:165–196, 2010). The work further explores possibilities of implementing Kemp...... to the International Standard Classification of Education. The main contribution of this work is the proposal of a conceptual framework of the cross-categorization approach that, inspired by Sartor (Artif Intell Law 17:217–251, 2009), attempts to explain reasoner’s inferential mechanisms....

  17. Transmitted Drug Resistance Among Recently Diagnosed Adults and Children in São Paulo, Brazil.

    Science.gov (United States)

    Guimarães, Paula Morena de Souza; Ferreira, João Leandro de Paula; Coelho, Luana Portes Ozório; Cavalcanti, Jaqueline de Souza; Lopes, Giselle Ibette Silva Lopez; Matsuda, Elaine Monteiro; Almeida, Flávia Jacqueline; Almeida, Valéria Correia; Campeas, Alexandre Ely; Junior, Luiz Carlos Pereira; Brígido, Luís Fernando de Macedo

    2015-12-01

    Transmitted drug resistance mutations (TDRM) have been a constant threat to treatment efficacy. We evaluated TDRM in plasma RNA of 217 antiretroviral therapy-naive patients from sites in the São Paulo metropolitan area, collected from 2012 to 2014. The partial HIV-1 polymerase region was sequenced using Big Dye terminators at an ABI 3130 Genetic Analyzer. TDRM was defined according to the Stanford database calibrated population resistance (CPR v.6.0), but other drug resistance mutations (DRM) considered at the IAS list (IAS, 2014) and at the Stanford HIV Database Genotyping Resistance Interpretation (GRI-HIVdb) were also described. Out of 78% (170/217) of patients with information on the time of diagnosis, most (83%, 141/170) had been recently diagnosed, with the first positive HIV serology at a median of 58 days (IQR 18-184). Subtype B predominated (70%), followed by subtype F (10%), BF (7.5%), C (7.5%), and BC (5%). TDRMs were observed in 9.2% (20/217, CI 95% 5.9% to 13.6%), mostly (5.2%) to nonnucleoside reverse transcriptase inhibitor (NNRTI) antiretroviral class. Among children and adolescents, only a single patient showed TDRMs. Additional non-CPR mutations were observed: 11.5% (25/217) according to IAS or 4.6% (10/217) according to GRI-HIVdb. Overall, 23.5% (51/217) of the cases had one or more DRM identified. TDRM prevalence differed significantly among some sites. These trends deserve continuous and systematic surveillance, especially with the new policies of treatment as prevention being implemented in the country.

  18. 先天性巨结肠及其类缘病的临床病理学分析%Hirschsprung's disease and its allied diseases: a clinicopathologic analysis

    Institute of Scientific and Technical Information of China (English)

    杨军; 刘妮; 康安静; 陈晓黎; 靳耀锋; 苏宝山; 黄莺

    2012-01-01

    目的 回顾性分析先天性巨结肠症(HD)及其类缘病(HAD)的组织病理学特征.方法 按照HD和HAD病理诊断标准,回顾性分析217例临床诊断为巨结肠患者的病理切片.进行病理学诊断.结果 217例临床诊断为巨结肠的病例中,典型HD仅占41.47% (90/217),男女比例为8∶1;HAD占58.53%(127/217),男女比例为2.85∶1.结论 按照HD和HAD病理学诊断标准,临床上表现为巨结肠的患儿中58.53%的病例为HAD,HAD与HD患儿男女比例明显不同,提示两者可能具有不同的发病机制.%Objective To investigate clinical and histopathological characteristics of Hirschsprung's disease (HD) and HD allied disease (HAD) by a retrospective analysis.Methods Records of 217 cases clinical diagnosed as megacolon were retrospectively analyzed according to the standard for HD and HAD pathologic diagnosis.Results Among the 217 cases, 90 (41. 47% ) cases were typical HD, and the sex ratio was 8: 1 ;. 127 (58. 53% ) cases were HAD, and the sex ratio was of 2. 85: 1. Conclusion Totally 58. 53% of cases are HAD in the cases clinically diagnosed as megacolon. At the same time, HAD cases have a different sex ratio from typical HD case, suggesting that they may have a different pathogenesis.

  19. 78 FR 78508 - Quarterly Rail Cost Adjustment Factor

    Science.gov (United States)

    2013-12-26

    ...-inclusive index of railroad input prices ] and the method for computing the rail cost adjustment factor... 208.7 5 DEPRECIATION 11.9 221.0 217.8 6 INTEREST 2.0 76.6 76.6 7 OTHER ITEMS \\2\\ 21.9 220.0 220.5 8... EQUIPMENT RENTS 5.6 208.0 207.6 5 DEPRECIATION 11.5 218.9 217.8 6 INTEREST 2.3 87.3 87.3 7 OTHER ITEMS...

  20. Protein: FBA2 [TP Atlas

    Lifescience Database Archive (English)

    Full Text Available enzyme E2 D2 Ubiquitin carrier protein D2, Ubiquitin-conjugating enzyme E2(17)KB 2, Ubiquitin-conjugating en...zyme E2-17 kDa 2, Ubiquitin-protein ligase D2 9606 Homo sapiens P62837 7322 3TGD, 2ESP, 2ESO, 3JW0, 3L1Y, 2ESK, 2C4O, 2ESQ, 1UR6, 1W4U, 2CLW, 3JVZ 3A33 7322 P62837 20152160 #20100118 ...

  1. Drug: D01573 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01573 Drug Etilefrine hydrochloride (JP16); Etilefrine hydrochloride (TN) C10H15NO...2. HCl 217.087 217.6925 D01573.gif Antihypotensive; Sympathomimetic Therapeutic category: 2119 ATC code: C01CA01 alpha1-adr...tion hsa04270(146+147+148) Vascular smooth muscle contraction hsa04970(146+147+148) Salivary secretion Therapeutic category of dr... 211 Cardiotonics 2119 Others D01573 Etilefrine hydrochloride (JP16) Anatomical T...AC STIMULANTS EXCL. CARDIAC GLYCOSIDES C01CA Adrenergic and dopaminergic agents C01CA01 Etilefrine D01573 Etilefrine hydr

  2. Spectral Estimation: An Overdetermined Rational Model Equation Approach.

    Science.gov (United States)

    1982-09-15

    procedure. This method was developed by Levinson and is commonly referred to as the Levinson- Durbin algorithm [24,[431. In this approach, one solves the...k-) /bo(k-l)1 2 (2.17a) ai (k) -i k)ai 1 j i k-1 (2.17b) Wb k 2 (k) 2((k-1)1 No r - (1 - lak I 11bok(12.17c Table 2.1. Levinson- Durbin Algorithm...a moderate mount of algebraic manipulation will reveal the validity of the solution as liven in Step 2 of Table 2.1 with k - 2 (with superscript (2

  3. Physical Activity

    DEFF Research Database (Denmark)

    Andersen, Lars Bo; Anderssen, Sigmund Alfred; Wisløff, Ulrik

    2014-01-01

    Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers.......Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers....

  4. 涤棉品种应用部分醇解PVA的浆纱实践%Sizing Practice of Using Partial Alcoholysis PVA in Polyester Cotton Variety

    Institute of Scientific and Technical Information of China (English)

    梁新乾; 朱亚慧

    2007-01-01

    为了减少涤棉混纺产品浆料配方中PVA的用量,降低上浆成本,应用PVA-217SB低醇解度PVA、润力浆料进行了上浆实践.结果表明:应用PVA-217SB低醇解度PVA、润力浆料上浆后,减少了PVA用量,提高了浆纱质量,减少了经向断头,提高了织机效率,并且降低了用浆成本.

  5. Disease: H01071 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available a deficiency in the ALDH2 is associated with the alcohol flush reaction. More than 40% of the East Asians po...mes that eliminate toxic aldehydes by catalysing their oxidation to non-reactive acids. It is reported that ...ion in the enzymatic activity when compared with the wild-type allele. Inherited metabolic disease hsa00010(...217) Glycolysis / Gluconeogenesis ALDH2 [HSA:217] [KO:K00128] OMIM: 610251 PMID:16792555 Dickson PA, James MR, Hea...on at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans. Alcohol

  6. 75 FR 16068 - Opportunity for Designation in the Amarillo, TX; Cairo, IL; State of Louisiana; State of North...

    Science.gov (United States)

    2010-03-31

    ... this official agency: Armstrong (north of Prairie Dog Town Fork of the Red River), Carson, Childress...), Harley, Hemphill, Hutchinson, Lipscomb, Moore, Ochiltree, Oldham, Potter, Randall (north of Prairie Dog Town Fork of the Red River, State Route 217 and FM 1062), Roberts, Sherman, and Wheeler Counties...

  7. Deteriorated Concrete from Liner of WIPP Waste Shaft

    Science.gov (United States)

    1992-06-01

    for US Department of Energy. Bensted, J. 1989. "Novel Cements - Sorel and Related Chemical Cements," il Cemento , Vol 86, No. 4, pp 217-228. Ben-Yair, M...Waste Isolation Pilot Plant. Massazza, F. 1985. "Concrete Resistance to Sea Water and Marine Environment," il Cemento , Vol 82, No. 1, pp 3-26. Mather

  8. 75 FR 54561 - Endangered and Threatened Wildlife and Plants; Proposed Rule To List the Ozark Hellbender...

    Science.gov (United States)

    2010-09-08

    ... dams constructed in the 1940s and 1950s on the upper White River, including Beaver, Table Rock, Bull... represented a range of lengths from 6.8 to 21.7 in (172 to 551 millimeters (mm)), indicating that reproduction... the upper White River, construction of Beaver, Table Rock, Bull Shoals, and Norfork dams in the...

  9. Construct Validity of Career Indecision: Negative Personality Traits as Predictors of Career Indecision.

    Science.gov (United States)

    Leong, Frederick T. L.; Chervinko, Stephanie

    1996-01-01

    College students (n=217) completed the Career Decision Scale, Multidimensional Perfectionism Scale, Self-Consciousness Scale, and Fear of Commitment Scale. Fear was a strong predictor of career indecision. Negative predictors were self-oriented perfectionism and social anxiety; positive predictors were socially prescribed perfectionism and private…

  10. Applying Common Latino Magazine Cover Line Themes to Health Communications

    Science.gov (United States)

    Delaney, Colleen L.; Barrios, Pamela; Lozada, Carolina; Soto-Balbuena, Kenlly; Martin-Biggers, Jennifer; Byrd-Bredbenner, Carol

    2016-01-01

    This study aimed to describe strategies used in magazine cover lines to capture the attention of Latino consumers. A content analysis of cover lines (n = 581) from six top-selling Latino women's and parenting magazines (n = 217 issues) sold in the United States identified 12 common themes: great/inspiring, beauty/health, bad/negative,…

  11. Image Dependent Relative Formation Navigation for Autonomous Aerial Refueling

    Science.gov (United States)

    2011-03-01

    OpenGL canonical viewing volume . . . . . . . . . . . . . . . . 36 2.16. Overview OpenGL process . . . . . . . . . . . . . . . . . . . . 38 2.17. Two arrow...device coordinate frame . . . . . . . . 36 CVV OpenGL canonical viewing volume . . . . . . . . . . . . . 36 GLimage OpenGL image frame...65 PSD Power Spectral Density . . . . . . . . . . . . . . . . . . . 67 FOGM first-order Gauss -Markov process . . . . . . . . . . . . . . 70 NM

  12. EST Table: FS917079 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS917079 E_FL_fufe_40D23_F_0 10/09/28 99 %/217 aa ref|NP_001040402.1| preimplantation... protein [Bombyx mori] gb|ABF51322.1| preimplantation protein [Bombyx mori] 10/09/12 81 %/213 aa FBpp02346

  13. Establishing the potential dependent equilibrium oxide coverage on platinum in alkaline solution and its influence on the oxygen reduction

    DEFF Research Database (Denmark)

    Wiberg, Gustav; Arenz, Matthias

    2012-01-01

    Publication year: 2012 Source:Journal of Power Sources, Volume 217 Gustav K.H. Wiberg, Matthias Arenz The oxidation process of polycrystalline platinum subjected to alkaline solution is re-examined using a combination of cyclic voltammetry and potential hold techniques in Ar, H2 and O2 purged 0.1 M...

  14. 77 FR 32626 - Transcontinental Gas Pipe Line Company, LLC; Notice of Intent To Prepare an Environmental Impact...

    Science.gov (United States)

    2012-06-01

    .... Transco would construct the first 2.17 miles of offshore pipeline from the LNYBL toward shore using... of this notice. Currently, the NPS, U.S. Environmental Protection Agency (EPA), and U.S. Army Corps... analysis. Water Resources: Impacts on off-shore and near-shore water quality. Assessment of...

  15. AcEST: BP912285 [AcEST

    Lifescience Database Archive (English)

    Full Text Available utative uncharacterized protein YHR217C OS... 31 4.6 sp|P08411|POLN_SFV Non-structural polyprotein OS=Semliki forest...ural polyprotein OS=Semliki forest virus PE=1 SV=2 Length = 2432 Score = 30.0 bits (66), Expect = 7.9 Identi

  16. Organization of Hospital Nursing, Provision of Nursing Care, and Patient Experiences with Care in Europe

    NARCIS (Netherlands)

    L. Bruyneel (Luk); B. Li (Baoyue); D. Ausserhofer (Dietmar); E.M.E.H. Lesaffre (Emmanuel); I. Dumitrescu (Irina); H.L. Smith (Herbert L.); D.M. Sloane (Douglas M.); L.H. Aiken (Linda); W. Sermeus (Walter)

    2015-01-01

    textabstractThis study integrates previously isolated findings of nursing outcomes research into an explanatory framework in which care left undone and nurse education levels are of key importance. A moderated mediation analysis of survey data from 11,549 patients and 10,733 nurses in 217 hospitals

  17. Urinary excretion of 3-methylhistidine and creatinine by healthy Dutch children during day and night. The influence of age and sex

    NARCIS (Netherlands)

    Speek, A.J.; Thissen, J.T.N.M.; Schrijver, J.

    1986-01-01

    The urinary excretion of 3-methylhistidine and creatinine and the urinary 3-methylhistidine to creatinine excretion ratio during day and night were investigated in a group of 103 healthy, normally fed Dutch children (52 boys and 51 girls) aged 2-17 years. The 3-methylhistidine to creatinine ratio of

  18. Testing predictive control of movement in children with developmental coordination disorder using converging operations

    NARCIS (Netherlands)

    Adams, I.L.J.; Lust, J.M.; Wilson, P.H.; Steenbergen, B.

    2017-01-01

    Recent systematic reviews (Wilson et al., 2013, Dev. Med. Child Neurol., 55, 217; Adams et al., 2014, Neurosci. Biobehav. Rev., 47C, 225) suggest that a common underlying problem in developmental coordination disorder (DCD) is the internal modelling deficit. The study presented here is

  19. 34 CFR 628.5 - What regulations apply to the Endowment Challenge Grant Program?

    Science.gov (United States)

    2010-07-01

    ... Program? 628.5 Section 628.5 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ENDOWMENT CHALLENGE GRANT PROGRAM....217. (iv) 34 CFR part 79 (Intergovernmental Review of Department of Education Programs and...

  20. Gclust Server: 101170 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 101170 PoTR_580412 Cluster Sequences Related Sequences(159) 217 eugene3.01200097 1 ...1.00e-99 14.29 0.0 0.0 0.0 0.0 0.0 Show 101170 Cluster ID 101170 Sequence ID PoTR_580412 Link to cluster seq

  1. Birth Order and Maladaptive Behavior in School-Aged Children.

    Science.gov (United States)

    Carmichael, Karla D.

    Drawing on Alfred Adler's theories on the effect of birth order on maladaptive behavior in children, this study focused on the relationship between birth order and the referral to counseling of school-aged children with maladaptive disorder. School-aged children (N=217) with academic or behavioral problems, ages 5 to 18, were referred to the staff…

  2. Computational Methods for Feedback Controllers for Aerodynamics Flow Applications

    Science.gov (United States)

    2007-08-15

    estimating that particular mode (Bayon de Noyer 1999). The above heuristic approach has been used by Bayon de Noyer (1999) in finding effective sensor...Systems", Journal of Optimization Theory and Applications, Vol. 25, No. 3, 1978, pp. 217-236. Bayon de Noyer , "Tail Buffet Alleviation of High

  3. Latent Trait Standardization of the Benzodiazepine Dependence Self-Report Questionnaire using the Rasch Scaling Model

    NARCIS (Netherlands)

    Kan, C.C.; Ven, A.H.G.S. van der; Breteler, M.H.M.; Zitman, F.G.

    2001-01-01

    The aim of the present study was to obtain standardized scores that correspond with the raw scores on the four Rasch scales of the Benzodiazepine Dependence-Self Report Questionnaire (Bendep-SRQ). The eligible normative group for standardization of the Bendep-SRQ scales consisted of 217 general prac

  4. Latent trait standardization of the benzodiazepine dependence self-report questionnaire using the Rasch scaling model.

    NARCIS (Netherlands)

    Kan, C.C.; Ven, A.H.G.S. van der; Breteler, M.H.M.; Zitman, F.G.

    2001-01-01

    The aim of the present study was to obtain standardized scores that correspond with the raw scores on the four Rasch scales of the Benzodiazepine Dependence-Self Report Questionnaire (Bendep-SRQ). The eligible normative group for standardization of the Bendep-SRQ scales consisted of 217 general prac

  5. Towards a Broader Conceptualization of Need, Stigma, and Barriers to Mental Health Care in Military Organizations: Recent Research Findings from the Canadian Forces

    Science.gov (United States)

    2011-04-01

    217-23. [11] Sareen J, Cox BJ, Afifi TO, Stein MB, Belik SL, Meadows G et al. Combat and peacekeeping operations in relation to prevalence of...screening of service members returning from Bosnia. J Appl Soc Psychol 2000;30:1599-618. [49] Sareen J, Cox BJ, Afifi TO, Stein MB, Belik SL, Meadows G

  6. EST Table: CK516272 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 9/29 61 %/212 aa ref|NP_001116821.1| 18 wheeler [Bombyx mori] dbj|BAB85498.1| 18 wheeler [Bombyx mori] 10/08...5 %/217 aa gi|91076478|ref|XP_972409.1| PREDICTED: similar to 18 wheeler [Tribolium castaneum] CK516272 swj ...

  7. Geochemical modeling of water-gas-rock interactions. Application to mineral diagenesis in geologic reservoirs; Modelisation geochimique des interactions eau-gaz-roche. Application a la diagenese minerale dans les reservoirs geologiques

    Energy Technology Data Exchange (ETDEWEB)

    Bildstein, O.

    1998-03-13

    The Ph.D. report describes a conceptual and numerical model for simulating gas-water-rock interaction during mineral diagenesis of sediments. The main specific features of this model are the following: applicable to open systems, half-implicit resolution numerical method, feedback on the texture evolution (grain model), existence of a gas phase, oxido-reduction phenomena. (author) 217 refs.

  8. 75 FR 6239 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-02-08

    .... 57579 (March 28, 2008), 73 FR 18587 (April 4, 2008)(SR-NASDAQ-2008-026)(notice of filing and immediate... Exchange Act Release No. 60874 (October 23, 2009), 74 FR 56682 (November 2, 2009)(SR-NASDAQ-2009-091.... Inc 117 AMR AMR Corp 217 MET MetLife Inc. 166 ANF Abercrombie & 187 MMM 3M Co. Fitch Co 172...

  9. How well does journal 'impact' work in the assessment of papers on clinical physiology and nuclear medicine?

    DEFF Research Database (Denmark)

    Hansen, HB; Henriksen, Jens Henrik Sahl

    1997-01-01

    This study reports a citation analysis of 217 scientific papers on clinical physiology and nuclear medicine published in 69 different journals during the years 1985-92. The actual citation frequency was compared with the journal 'impact factor' (i.e. the average number of times a paper is cited...

  10. Gclust Server: 44444 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 44444 HSA_46409332 Cluster Sequences Related Sequences(39) 217 NP_997232.1 hypothet...ical protein LOC284739 ; no annotation 2 1.00e-99 0.0 0.0 0.0 0.0 0.0 12.5 Show 44444 Cluster ID 44444 Seque

  11. An Overview of Sleep Deprivation and The Ameliorative Effects of Modafinil

    Science.gov (United States)

    2002-11-01

    Nap: Evolution, Chronobiology, and Functions of Polyphasic and Ultrashort Sleep , C. Stampi, Editor. 1992, Birkhauser: Boston. p. 217-241. 3. Babkoff...UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADP013763 TITLE: An Overview of Sleep Deprivation and The Ameliorative...Effects of Modafinil DISTRIBUTION: Approved for public release, distribution unlimited rhis paper is part of the following report: TITLE: Sleep

  12. AcEST: BP916758 [AcEST

    Lifescience Database Archive (English)

    Full Text Available tenolidase homolog OS=Xenopus laevis GN=cmbl PE=2 SV=1 Length = 246 Score = 47.4 bits (111), Expect = 2e-05 ...EQVSTLTQKLKEHCIV--NYQVKTFSGQTHGFVHR 217 >sp|Q6P7K0|CMBL_XENTR Carboxymethylenebutenolidase homolog OS=Xenopus tropicalis GN=cmb

  13. Data of evolutionary structure change: 1GCVC-1CBMC [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1GCVC-1CBMC 1GCV 1CBM C C -AFTACEKQTIGKIAQVLAKSPEAYGAECLARLFVTHPG... CA 220 ALA CA 206 LYS CA 238 1CBM... C 1CBMC FGDLSTPDAVMGNPK ASP CA 217 1CBM C 1CBM...2.8415520191192627 2 1CBM

  14. Correlates of Early Alcohol and Drug Use in Hispanic Adolescents: Examining the Role of ADHD with Comorbid Conduct Disorder, Family, School, and Peers

    Science.gov (United States)

    Lopez, Barbara; Schwartz, Seth J.; Prado, Guillermo; Huang, Shi; Rothe, Eugenio M.; Wang, Wei; Pantin, Hilda

    2008-01-01

    This study examined correlates of early adolescent alcohol and drug use in a community sample of 217 eighth-grade adolescents with behavior problems and from Hispanic/Latino immigrant families. Structural equation modeling was used to examine relationships of multiple contexts (e.g., family, school, and peers) to alcohol and drug use. Results…

  15. Data of evolutionary structure change: 1JDZC-2IQ5B [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available > 2IQ5B VRLDG-ASLHF >EEE - ...SYNQGGLFYQY e>E HHHHHHture> 2IQ5B QTESH----AVKIV > HH----HHHHH...ain>1JDZC EELEKSVMDGAKAV re...> HHHHHHHHHHHH> ATOM 5061 CA GLU C 217 95.716 121.480 11.777 1.

  16. Time use of Hellene 3rd and 4th graders during a school day

    NARCIS (Netherlands)

    Vleioras, Georgios

    2010-01-01

    Using data from the time diaries of 164 Hellene 3rd and 4th graders interviewed in their homes in March 2007, individual differences in time-use patterns were investigated. The participants rested for 9 hours 10 minutes, and spent 57.0%, 21.7%, and 5.0% of their waking time on school-related activit

  17. The Taliban Insurgency and an Analysis of ’Shabnamah’ (Night Letters)

    Science.gov (United States)

    2007-09-01

    Structures, and Cultural Framings (Cambridge: Cambridge University Press, 1996), or Doug McAdam, Sidney Tarrow and Charles Tilly, ‘Toward an Integrated...in From Structure to Action, vol. 1, edited by B. Klandermans, H. Kriesi and S. Tarrow (Greenwich, CT: JAI Press, 1988), pp.197–217. 11. For example

  18. Planck early results. VI. The High Frequency Instrument data processing

    DEFF Research Database (Denmark)

    Bucher, M.; Castex, G.; Colley, J.-M.;

    2011-01-01

    We describe the processing of the 336 billion raw data samples from the High Frequency Instrument (HFI) which we performed to produce six temperature maps from the first 295 days of Planck-HFI survey data. These maps provide an accurate rendition of the sky emission at 100, 143, 217, 353, 545 and...

  19. 47 CFR 90.259 - Assignment and use of frequencies in the bands 216-220 MHz and 1427-1432 MHz.

    Science.gov (United States)

    2010-10-01

    ... COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Standards for... applicants that establish eligibility in the Industrial/Business Pool. (2) All operation is secondary to the fixed and mobile services, including the Low Power Radio Service. (3) In the 216-217 MHz band, no...

  20. Resolution of the Diagnosis among Parents of Children with Autism Spectrum Disorder: Associations with Child and Parent Characteristics

    Science.gov (United States)

    Milshtein, Shahaf; Yirmiya, Nurit; Oppenheim, David; Koren-Karie, Nina; Levi, Shlomit

    2010-01-01

    Resolution with the diagnosis of one's child involves coming to terms with and accepting the diagnosis and its implications. Parental resolution with the diagnosis was examined among 61 mothers and 60 fathers of 61 children with autism spectrum disorders aged 2-17 years. We investigated resolution rates and subtypes, and associations between…

  1. Cold Temperature and Biodiesel Fuel Effects on Speciated Emissions of Volatile Organic Compounds from Diesel Trucks

    Science.gov (United States)

    Speciated volatile organic compounds (VOCs) were measured in diesel exhaust from three medium heavy-duty trucks equipped with modern aftertreatment technologies. Emissions testing was conducted on a chassis dynamometer at two ambient temperatures (-6.7°C and 21.7°C) operating on ...

  2. Drug: D01813 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01813 Drug Inositol hexanicotinate (JAN); Inositol niacinate (USAN); Inositol nico...ual organs 21 Cardiovascular agents 217 Vasodilators 2172 Peripheral artery dilators D01813 Inositol hexan...icotinate D01813 Inositol hexanicotinate (JAN); Inositol niacinate (USAN); Inositol nicotinate (INN) CAS: 65

  3. Arts Education and Creativity Enhancement in Young Children in Hong Kong

    Science.gov (United States)

    Hui, Anna N. N.; He, Mavis W. J.; Ye, Shengquan Sam

    2015-01-01

    The present study aimed at assessing Hong Kong young children's gains in creativity and their teachers' application of arts education after a one-year artists-teachers collaborative arts education project that involves various art forms (i.e. drama, visual arts and integrated). Participants included 790 young children, 217 parents and 65 teachers…

  4. The High School Students' Perceptions and Attitudes toward Bioenergy

    Science.gov (United States)

    Özbas, Serap

    2016-01-01

    This research, which was tried with 217 high school students, was carried out to determine the perceptions and attitudes related to the usage of bioenergy. The research results showed that the students had the perception that there would be lack of food due to global warming, but bioenergy would prevent the world from global warming. Moreover,…

  5. Kosteneffectiviteitsanalyse van de cursus Geen Paniek

    NARCIS (Netherlands)

    Meulenbeek, P.A.M.; Boonk, E.; Prenger, R.; Smit, F.

    2013-01-01

    Een kosteneffectiviteitsanalyse van een cursus voor mensen met lichte tot matige paniekklachten Geen Paniek werd uitgevoerd. 217 cursisten namen deel aan de gerandomiseerde gecontroleerde trial (RCT). 109 deelnemers werden toegewezen aan de interventie, 108 deelnemers kwamen op de wachtlijst met vri

  6. China’s Mineral Exploration Market Downturn Causes Decline of Investment in Bauxite

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    <正>According to a survey report conducted recently by China Geological Survey Development Research Center,in the first half of 2014,China’s mineral exploration market continued to decline,with the investment in exploration of non-fuel minerals dropping by13.7%and drilling workload dropping by21.7%.According to statistical analysis of the Center,

  7. Textile Recycling, Convenience, and the Older Adult.

    Science.gov (United States)

    Domina, Tanya; Koch, Kathryn

    2001-01-01

    Results of a study to examine the recycling practices and needs of older adults (n=217) indicated that older adults do recycle traditional materials, but need accommodations for physical limitations. They report textile recycling as time consuming and difficult and used donations to religious organizations as their principal means of textile…

  8. Domain Modeling: NP_071911.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_071911.3 chr10 Solution structure of the tandem four zf-C2H2 domain repeats of m...urine GLI-Kruppel family member HKR3 c2dlqa_ chr10/NP_071911.3/NP_071911.3_holo_111-217.pdb psi-blast 112C,1

  9. Domain Modeling: NP_001561.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001561.3 chr3 Structural Basis for the Interaction of TAK1 Kinase with its Activ...ating Protein TAB1 p2evaa_ chr3/NP_001561.3/NP_001561.3_holo_194-543.pdb psi-blast 216I,217S,218Q,219G,224V,

  10. Genomic characterization of a core set of the USDA-NPGS Ethiopian sorghum germplasm collection

    Science.gov (United States)

    The USDA Agriculture Research Service National Plant Germplasm System (NPGS) preserves the largest sorghum germplasm collection in the world, which includes 7,217 accessions from the center of diversity in Ethiopia. The characterization of this exotic germplasm at a genome-wide scale will improve co...

  11. 77 FR 37007 - Applications for New Awards: National Institute on Disability and Rehabilitation Research...

    Science.gov (United States)

    2012-06-20

    ... living, family support, and economic and social self-sufficiency of individuals with disabilities... private agencies, including for-profit agencies; public or private organizations, including for-profit... discretionary grant competition, the Secretary may consider, under 34 CFR 75.217(d)(3), the past performance...

  12. Differences in injury risk and characteristics between Dutch amateur and professional soccer players

    NARCIS (Netherlands)

    Anne-Marie van Beijsterveldt, A. M C; Stubbe, J. H.; Schmikli, S. L.; Van De Port, I. G L; Backx, F. J G

    2015-01-01

    Objectives To compare the incidence and characteristics of injuries between Dutch amateur and professional male soccer players during one entire competition season. Design A prospective two-cohort design. Methods During the 2009–2010 season, 456 Dutch male amateur soccer players and 217 professional

  13. 77 FR 24835 - Airworthiness Directives; The Boeing Company Airplanes

    Science.gov (United States)

    2012-04-26

    ...-217-AD; Amendment 39-17031; AD 2012-08-14] RIN 2120-AA64 Airworthiness Directives; The Boeing Company... new airworthiness directive (AD) for certain The Boeing Company Model 767 airplanes. This AD was... this AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707,...

  14. Implementing E-Learning Designed Courses in General Education

    Science.gov (United States)

    Nuangchalerm, Prasart; Sakkumduang, Krissada; Uhwha, Suleepornn; Chansirisira, Pacharawit

    2014-01-01

    The aim of this study is to implement e-learning designed course for general education. The study employed 3 phases for developing e-learning course: contextual study, designing, and implementing. Two courses general education, 217 undergraduate students are participated the study. Research tool consisted of interview about e-learning form and…

  15. A ribosomal S-6 kinase-mediated signal to C/EBP-beta is critical for the development of liver fibrosis.

    Directory of Open Access Journals (Sweden)

    Martina Buck

    Full Text Available BACKGROUND: In response to liver injury, hepatic stellate cell (HSC activation causes excessive liver fibrosis. Here we show that activation of RSK and phosphorylation of C/EBPbeta on Thr217 in activated HSC is critical for the progression of liver fibrosis. METHODOLOGY/PRINCIPAL FINDINGS: Chronic treatment with the hepatotoxin CCl(4 induced severe liver fibrosis in C/EBPbeta(+/+ mice but not in mice expressing C/EBPbeta-Ala217, a non-phosphorylatable RSK-inhibitory transgene. C/EBPbeta-Ala217 was present within the death receptor complex II, with active caspase 8, and induced apoptosis of activated HSC. The C/EBPbeta-Ala217 peptides directly stimulated caspase 8 activation in a cell-free system. C/EBPbeta(+/+ mice with CCl(4-induced severe liver fibrosis, while continuing on CCl(4, were treated with a cell permeant RSK-inhibitory peptide for 4 or 8 weeks. The peptide inhibited RSK activation, stimulating apoptosis of HSC, preventing progression and inducing regression of liver fibrosis. We found a similar activation of RSK and phosphorylation of human C/EBPbeta on Thr266 (human phosphoacceptor in activated HSC in patients with severe liver fibrosis but not in normal livers, suggesting that this pathway may also be relevant in human liver fibrosis. CONCLUSIONS/SIGNIFICANCE: These data indicate that the RSK-C/EBPbeta phosphorylation pathway is critical for the development of liver fibrosis and suggest a potential therapeutic target.

  16. Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

    DEFF Research Database (Denmark)

    Taylor, Jenny C; Martin, Hilary C; Lise, Stefano

    2015-01-01

    To assess factors influencing the success of whole-genome sequencing for mainstream clinical diagnosis, we sequenced 217 individuals from 156 independent cases or families across a broad spectrum of disorders in whom previous screening had identified no pathogenic variants. We quantified the numb...

  17. 21 CFR 520.2087 - Roxarsone soluble powder.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Roxarsone soluble powder. 520.2087 Section 520...) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS ORAL DOSAGE FORM NEW ANIMAL DRUGS § 520.2087 Roxarsone soluble powder. (a) Specifications. Each ounce (avoirdupois) of soluble powder contains 21.7 grams of...

  18. Processes of Skill Performance: A Foundation for the Design and Use of Training Equipment

    Science.gov (United States)

    1983-11-01

    R. D. Jean Piaget and the world of the child. American Psychologist, 1966, 21, 207-217. Turvey, M. T. Visual processing and short-term memory. In W. K...White, 1959); cognitive dissonance (Festinger, 1957); discrepant cognitive organization (Feather, 1971); and Piaget s schematic disequilibrium

  19. Training in Psychiatric Genomics during Residency: A New Challenge

    Science.gov (United States)

    Winner, Joel G.; Goebert, Deborah; Matsu, Courtenay; Mrazek, David A.

    2010-01-01

    Objective: The authors ascertained the amount of training in psychiatric genomics that is provided in North American psychiatric residency programs. Methods: A sample of 217 chief residents in psychiatric residency programs in the United States and Canada were identified by e-mail and surveyed to assess their training in psychiatric genetics and…

  20. Reference: AT1BOX [PLACE

    Lifescience Database Archive (English)

    Full Text Available AT1BOX Ueda T, Pichersky E, Malik VS, Cashmore AR The level of expression of the to...mato rbcs-3A gene is modulated by a far-upstream promoter element in a developmentary regulated manner. Plant Cell 1:217-227 (1989) PubMed: 2535544; GenBank: S44160; ...

  1. AcEST: BP919529 [AcEST

    Lifescience Database Archive (English)

    Full Text Available a... 244 2e-63 tr|A7NT92|A7NT92_VITVI Glucose-1-phosphate adenylyltransferase O... 240 2e-62 tr|A9TZP1|A9TZP...DADITISCVPIDDSRASD 1 LYRMDYMDFVQKH DS+ADIT+SCVP+DDSRASD Sbjct: 217 LYRMDYMDFVQKHIDSNADITVSCVPMDDSRASD 250 >tr|A9TZP1|A9TZP

  2. Data of evolutionary structure change: 1C4TC-1DPCA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1C4TC-1DPCA 1C4T 1DPC C A -----------ARSEKRVP----RKRVAERLLEAKNSTA...> ARG CA 109 VAL CA 154 ALA CA 140 1DPC... A 1DPCA IEEVPMTRLMQIGA GLU CA 181 1DPC A 1DPC... TYR CA 237 HIS CA 284 ASN CA 217 1DPC

  3. 77 FR 37408 - Secretary's Advisory Committee on Human Research Protections

    Science.gov (United States)

    2012-06-21

    ... Protections (OHRP), or Julia Gorey, J.D., Executive Director, SACHRP; U.S. Department of Health and Human...; email address: Julia.Gorey@hhs.gov . SUPPLEMENTARY INFORMATION: Under the authority of 42 U.S.C. 217a... as sign language interpretation or other reasonable accommodations, should notify the...

  4. 76 FR 58006 - Meeting of the Secretary's Advisory Committee on Human Research Protections

    Science.gov (United States)

    2011-09-19

    ... Protections (OHRP), or Julia Gorey, J.D., Executive Director, SACHRP; U.S. Department of Health and Human...-mail address: Julia.Gorey@hhs.gov . SUPPLEMENTARY INFORMATION: Under the authority of 42 U.S.C. 217a... who plan to attend the meeting and need special assistance, such as sign language interpretation...

  5. 76 FR 37354 - Meeting of the Secretary's Advisory Committee on Human Research Protections

    Science.gov (United States)

    2011-06-27

    ... Protections (OHRP), or Julia Gorey, J.D., Executive Director, SACHRP; U.S. Department of Health and Human...-mail address: Julia.Gorey@hhs.gov . SUPPLEMENTARY INFORMATION: Under the authority of 42 U.S.C. 217a... sign language interpretation or other reasonable accommodations, should notify the designated...

  6. 77 FR 58383 - Secretary's Advisory Committee on Human Research Protections

    Science.gov (United States)

    2012-09-20

    ... Julia Gorey, J.D., Executive Director, SACHRP; U.S. Department of Health and Human Services, 1101...: Julia.Gorey@hhs.gov . SUPPLEMENTARY INFORMATION: Under the authority of 42 U.S.C. 217a, Section 222 of.... Individuals who plan to attend the meeting and need special assistance, such as sign language...

  7. 78 FR 36783 - Meeting of the Secretary's Advisory Committee on Human Research Protections

    Science.gov (United States)

    2013-06-19

    ... (OHRP), or Julia Gorey, J.D., Executive Director, SACHRP; U.S. Department of Health and Human Services... address: Julia.Gorey@hhs.gov . SUPPLEMENTARY INFORMATION: Under the authority of 42 U.S.C. 217a, Section.... Individuals who plan to attend the meeting and need special assistance, such as sign language...

  8. 75 FR 59264 - Secretary's Advisory Committee on Human Research Protections

    Science.gov (United States)

    2010-09-27

    ... (OHRP), or Julia Gorey, J.D., Executive Director, SACHRP; U.S. Department of Health and Human Services... address: Julia.Gorey@hhs.gov . SUPPLEMENTARY INFORMATION: Under the authority of 42 U.S.C. 217a, Section.... Individuals who plan to attend the meeting and need special assistance, such as sign language...

  9. 78 FR 12061 - Meeting of the Secretary's Advisory Committee on Human Research Protections

    Science.gov (United States)

    2013-02-21

    ... Protections (OHRP), or Julia Gorey, J.D., Executive Director, SACHRP; U.S. Department of Health and Human...; email address: Julia.Gorey@hhs.gov . SUPPLEMENTARY INFORMATION: Under the authority of 42 U.S.C. 217a.... Individuals who plan to attend the meeting and need special assistance, such as sign language...

  10. The Effects of Family Disruption on Adolescent Males and Females.

    Science.gov (United States)

    Slater, Elisa J.; And Others

    1983-01-01

    Examined the effects of separation and divorce on adolescents' (N=217) self-image, anxiety, locus of control, and perception of their family. Results indicated males from disrupted homes had better self-concepts and better perceptions of their family environment than those from intact homes. The opposite results were found among females. (JAC)

  11. Instruction Strategies Work out by Mathematics Teachers: Evaluating the Affect on Bachelor of Education

    Science.gov (United States)

    Khan, Sumaira; Haider, Syed Zubair; Bukhari, Amjad Ali

    2016-01-01

    The main objective of this research is to study the different instruction strategies implemented by Mathematics teachers and evaluating its affect on Bachelor of Education (B.Ed) level. To complete the study, two samples 34 teachers and 217 students were taken randomly. A five point Likert scale comprising 40 statements was prepared and…

  12. 77 FR 69634 - Guidance for Industry on Evaluating the Effectiveness of Anticoccidial Drugs in Food-Producing...

    Science.gov (United States)

    2012-11-20

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry on Evaluating the Effectiveness of Anticoccidial Drugs in Food-Producing Animals; Availability AGENCY: Food and Drug Administration, HHS. ACTION... industry 217 entitled ``Evaluating the Effectiveness of Anticoccidial Drugs in Food-Producing...

  13. 12.4.Colon,rectum and anus

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920116 A study on chromosome instabiltyin patients with large bowel carcinoma andlarge bowel adenoma.Li Minglie (李明烈),etal.Shanghai Cancer Instit.Tumor 1991; 11 (5):215-217.The chromosome instability of peripheral lym-phocytes was studied in 10 patients with largebowel carcinoma (LBC),10 patients with large

  14. 11.RESPIRATORY SYSTEM

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    11.1.Lung function930671 The effects of persantine on pulmonary arte-rial pressure of rats exposed to hypoxia.RAN Pixin,Respir Dis Instit,Tongji Hosp,TongjiMed Univ,Wuhan,430030.Chin J Tuberc & RespirDis 1993;16(4):216—217.In the chronic hypoxic model of pulmonary hyper-

  15. Acute toxicity and histopathology of channel catfish fry exposed to peracetic acid

    Science.gov (United States)

    Channel catfish Ictalurus punctatus yolk-sac fry and swim-up fry were exposed to peracetic acid (PAA) for 48h in static toxicity bioassays at 23C. The test water was 217 and 126 mg/L (as CaCO3) total alkalinity and total hardness, respectively. Probit LC50 values were estimated with the trimmed Sp...

  16. Dicty_cDB: Contig-U16028-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 150 2e-44 AC140034_6( AC140034 |pid:none) Medicago truncatula clone mth2-17g... 150 2e-44 AF410883_1( AF410883 |pid:none) Franklin...ralabidochromis chilotes isolate... 140 3e-44 AF410881_1( AF410881 |pid:none) Frankliniella occidentalis cys

  17. 78 FR 67223 - Proposed Guidance for Fuel Cycle Facility; Material Control and Accounting Plans and Completing...

    Science.gov (United States)

    2013-11-08

    ... From the Federal Register Online via the Government Publishing Office ] Vol. 78 Friday, No. 217...- 0096) amending the NRC's MC&A regulations applicable to various types of special nuclear material (SNM... Rulemaking Web site: Go to http://www.regulations.gov and search for Docket ID NRC-2013-0195....

  18. Identification of miRNA Signatures Associated with Epithelial Ovarian Cancer Chemoresistance with Further Biological and Functional Validation of Identified Key miRNAs

    Science.gov (United States)

    2012-08-01

    confluent. A sterile 200 μl pipette tip was used to scratch the cells to form a wound. The cells were washed with PBS and cultured in serum-free medium... Nanotechnology 2012, DOI:10.1038/nnano.2011.217 [18] Fang, Z.; Kelley, S. O. Analytical Chemistry. Jan. 2009, DOI:10.1021/ac801890f [19] Song, F.; Zhou

  19. 75 FR 15991 - Designation of Greece for the Visa Waiver Program

    Science.gov (United States)

    2010-03-31

    ... regarding whether citizens or nationals of the country represent a threat to the security or welfare of the... / Wednesday, March 31, 2010 / Rules and Regulations#0;#0; ] DEPARTMENT OF HOMELAND SECURITY 8 CFR Part 217 RIN.... ACTION: Final rule; technical amendment. SUMMARY: Citizens and eligible nationals of participating...

  20. Patellar Tendinitis

    Science.gov (United States)

    ... tendons and make them more likely to rupture. Platelet-rich plasma injection. This type of injection has been tried ... Joint Diseases. 2014;72:217. AskMayoExpert. When are platelet-rich plasma (PRP) peripheral injections indicated for tendinopathy? Rochester, Minn.: ...

  1. Evaluation of the Fake Resistance of a Forced-choice Paired-comparison Computer Adaptive Personality Measure

    Science.gov (United States)

    2008-08-01

    C. C., & Hunt, S. T. (2002). How effective are people at faking on personality questionnaires? Personality and Individual Differences , 32, 247-256...on personality measures. Personality and Individual Differences , 24 (2), 217-227. 15 Mueller-Hanson, R., Heggestad, E. D., & Thornton, III, G

  2. Exploring the Corollaries of Students' Social Justice Intentionality

    Science.gov (United States)

    Smith, Laura; Lau, Michael Y.

    2013-01-01

    The preparation of students to take part in social justice advocacy has been increasingly embraced within higher education in the USA; nevertheless, the corollaries of social justice intentionality and commitment among students have yet to be investigated thoroughly. To contribute to the study of this question, data from 217 American psychology…

  3. Projecting Continuing Student Enrolments: A Comparison of Approaches

    Science.gov (United States)

    Aitken, Robert; Young, Anne; McConkey, Kevin

    2011-01-01

    Higher education in Australia is undergoing a comprehensive reform with particular focus on higher levels of attainment by increasing access to university study for Australians from all backgrounds. To support the government's ambition of around 217,000 additional graduates by 2025, it has committed to removing caps and funding student places on…

  4. Predicting Involuntary Separation of Enlisted Personnel.

    Science.gov (United States)

    1980-01-01

    involuntary separation 20 ABSTRACT tConinue on rev -.. side It rect.ssaty and id.. nif hy block rnmhirl ,This report contains lh’ results of a study to compare...Subsample Size - 1000 Predicted 1 593 204 590 217 Base Rate - 65% Predicted 0 57 146 ( A1 133 Classification Accuracy (7’) 73.9 72.3 Subsample Size

  5. Storytelling Slide Shows to Improve Diabetes and High Blood Pressure Knowledge and Self-Efficacy: Three-Year Results among Community Dwelling Older African Americans

    Science.gov (United States)

    Bertera, Elizabeth M.

    2014-01-01

    This study combined the African American tradition of oral storytelling with the Hispanic medium of "Fotonovelas." A staggered pretest posttest control group design was used to evaluate four Storytelling Slide Shows on health that featured community members. A total of 212 participants were recruited for the intervention and 217 for the…

  6. A highly sensitive spin-valve transistor

    NARCIS (Netherlands)

    Erve, van 't O.M.J.; Vlutters, R.; Anil Kumar, P.S.; Kim, S.D.; Jansen, R.; Lodder, J.C.; Hadjipanayis, G.C.

    2001-01-01

    In this paper we present a spin-valve transistor made with a silicon on insulator wafer as emitter and a double sided polished Si wafer as collector. Using vacuum metal bonding we obtain a three terminal device in which a spin-valve layer is sandwiched between two Si wafers. We measure a 217% change

  7. Political Culture and the Nature of Political Participation in Egypt.

    Science.gov (United States)

    1980-06-01

    Nasser’s Egypt, Austin: Univ. of Texas Press, 1971. Meisel, J.H., The Myth of the Ruling Class: Gaetano Mosca and the Elite, Ann Arbor: Univ. of Michigan... Mosca called the "second strata of the ruling class" - the strata without which the leadership could not 27 rule (Meisel 1962, p. 217]. The clientage

  8. A Systematic Review of Psychosocial Interventions for Adults with Autism Spectrum Disorders

    Science.gov (United States)

    Bishop-Fitzpatrick, Lauren; Minshew, Nancy J.; Eack, Shaun M.

    2013-01-01

    Individuals with autism spectrum disorders (ASD) spend the majority of their lives as adults, and psychosocial interventions show promise for improving outcomes in this population. This research conducted a systematic review of all peer-review studies evaluating psychosocial interventions for adults with ASD. A total of 1,217 studies were…

  9. Unmanned Aircraft Pilot Medical Certification Requirements

    Science.gov (United States)

    2007-02-01

    Warren Silberman represented the FAA Aerospace Medical Certification Division in regard to the medical certification require- ments. Given that the...Johnson, Marca Access 5 marca@direcway.com 410-961-3149 McCarley, Jason U of Illinois Institute of Aviation mccarley@uiuc.edu 217-244-8854 Silberman

  10. El papel de la Inteligencia Emocional en la resolución de problemas sociales en estudiantes adolescentes = The role of Emotional Intelligence in solving social problems in a sample of adolescent’s students

    OpenAIRE

    Pena Garrido, Mario; Extremera Pacheco, Natalio; Rey Peña, Lourdes

    2011-01-01

    La presente investigación, con una muestra de 217 adolescentes, se centra en el análisis de la relación entre la inteligencia emocional percibida (IEP) y el grado en que el estudiante afronta y soluciona problemas sociales. Los resultados evidenciaron

  11. International Symposium on Bioorganic Chemistry Held in New York, New York on 6-8 May 1985.

    Science.gov (United States)

    1985-12-23

    Restriction Enzymes. By FRITZ ECKSTEIN........................................................ 217 The Mechanism of Action of Phenylalanine Hydroxylase ...37. ECKSTEIN, F., P. J. ROMANIUK & B. A. CONNOLLY. 1982. Methods Enzymol. 87:197- 212. The Mechanism of Action of Phenylalanine Hydroxylase STEPHEN J...from L- phenylalanine and molecular oxygen is catalyzed by L- phenylalanine hydroxylase ( phenylalanine 4-monooxygenase, EC 1.14.16.1) through the agency

  12. International Symposium on Bioorganic Chemistry Held in New York, New York on May 6-8, 1985 (Annals of the New York Academy of Sciences, Volume 471)

    Science.gov (United States)

    1986-06-06

    217 The Mechanism of Action of Phenylalanine Hydroxylase . By STEPHEN J. BENKOViC, LESLIE...ROMANIUK & B. A. CONNOLLY. 1982. Methods Enzymol. 87: 197- 212. The Mechanism of Action of Phenylalanine Hydroxylase STEPHEN J. BENKOVICa LESLIE M...and molecular oxygen is catalyzed by L- phenylalanine hydroxylase ( phenylalanine 4-monooxygenase, EC 1.14.16.1) through the agency of a tetrahydropterin

  13. 78 FR 5439 - Environmental Impacts Statements; Notice of Availability

    Science.gov (United States)

    2013-01-25

    ... EIS No. 20130009, Final EIS, NPS, HI, Hawaii Volcanoes National Park Project, Protecting and Restoring..., Contact: J. Michael Bowen 217-492-4600. EIS No. 20130015, Draft Supplement, FHWA, CA, Mid County Parkway.../23/2009, Contact: Larry Blevin 916-978-6037. Revision to FR Notice Published 10/ 09/2009; The...

  14. High and Mighty: Implicit Associations between Space and Social Status

    Science.gov (United States)

    2011-10-10

    e.g., Piaget , 1927/1969; Tversky et al., 1991). To date, dozens of experiments across a wide range of disciplines, from psychology to anthropol- ogy...The Psychology of Learn- ing and Motivation, ed. B. H. Ross (Burlington: Academic Press), 217–248. Piaget , J. (1927/1969). The Child’s Con- ception of

  15. Structure of the SH3 domain of rat endophilin A2

    OpenAIRE

    Loll, Patrick J.; Swain, Evelyn; Chen, Yuan; Turner, Brian T.; Zhang, Ji-fang

    2008-01-01

    The crystal structure of the SH3 domain of rat endophilin A2 has been determined by the multiwavelength anomalous dispersion method and refined at a resolution of 1.70 Å to R and R free values of 0.196 and 0.217, respectively.

  16. Analysis of the weight loss of the testicles of mice after 14 and 400 MeV neutron irradiation

    CERN Document Server

    Laurent, J M

    1974-01-01

    The weight loss of the testicles was examined 28 days after neutron irradiation. A mathematical model was developed for evaluating cellular survival curves. The relative biological efficiency, determined using the value of D/sub 0/ calculated from the survival curves obtained, is 2.17 for 400 MeV neutron beams and 2.58 for 14 MeV neutron beams.

  17. Effect of stocking large channel catfish in a biofloc technology production system on production and incidence of common microbial off-flavor compounds

    Science.gov (United States)

    Density-dependent production and incidence of common microbial off-flavors caused by geosmin and 2-methylisoborneol were investigated in an outdoor biofloc technology production system stocked with stocker-size (217 g/fish) channel catfish at 1.4, 2.1, or 2.8 kg/m3. Individual weight at harvest rang...

  18. DMPD: Translational mini-review series on Toll-like receptors: recent advances inunderstanding the role of Toll-like receptors in anti-viral immunity. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17223961 Translational mini-review series on Toll-like receptors: recent advances i...147(2):217-26. (.png) (.svg) (.html) (.csml) Show Translational mini-review series on Toll-like receptors: r...nity. PubmedID 17223961 Title Translational mini-review series on Toll-like receptors: recent advances inund

  19. Atorvastatin affects low density lipoprotein and non-high density lipoprotein cholesterol relations with apolipoprotein B in type 2 diabetes mellitus : modification by triglycerides and cholesteryl ester transfer protein

    NARCIS (Netherlands)

    Kappelle, Paul J.W.H.; Zwang, Louwerens; Huisman, Menno V.; Banga, Jan Dirk; Sluiter, Wim. J.; Dallinga-Thie, Geesje M.; Dullaart, Robin P. F.

    2009-01-01

    Objectives: Non-HDL-cholesterol (non-HDL-C) and apolipoprotein (apo) B are proposed as treatment targets. The extent to which statin therapy affects relationships of LDL-C and non-HDL-C with apoB was examined in type 2 diabetes. Methods: Analyses were performed in 217 hypertriglyceridaemic type 2 di

  20. 76 FR 33764 - Announcement of Meeting of the Secretary's Advisory Committee on National Health Promotion and...

    Science.gov (United States)

    2011-06-09

    ... Health Promotion. ACTION: Notice of Meeting. Authority: 42 U.S.C. 217a, Section 222 of the Public Health... committee meeting regarding the national health promotion and disease prevention objectives for 2020. This... Committee on National Health Promotion and Disease Prevention Objectives for 2020 will address efforts...

  1. 76 FR 16777 - Announcement of Meeting of the Secretary's Advisory Committee on National Health Promotion and...

    Science.gov (United States)

    2011-03-25

    ... Health Promotion. ACTION: Notice of meeting. Authority: 42 U.S.C. 217a, Section 222 of the Public Health... meeting regarding the national health promotion and disease prevention objectives for 2020. This meeting... Committee on National Health Promotion and Disease Prevention Objectives for 2020 (Committee) will...

  2. Water Reclamation and Reuse.

    Science.gov (United States)

    Smith, Daniel W.

    1978-01-01

    Presents a literature review of water reclamation and reuse. This review covers: (1) water resources planning; (2) agriculture and irrigation; (3) ground recharge; (4) industrial reuse; (5) health considerations; and (6) technology developments. A list of 217 references is also presented. (HM)

  3. Synthesis and Physicochemical Properties of [19,20-13C]-17α-Ethinylestradiol

    NARCIS (Netherlands)

    Kraan, G.P.B.; Drayer, N.M.; Kruizinga, W.H.; Vaalburg, W.; Hummelen, J.C.

    1989-01-01

    13C2-17α-ethinylestradiol (13C2-EE2) was synthesized from estrone and 13C2-C2H2-gas to measure the metabolic clearance rate and the plasma concentration of 17α-ethinylestradiol (EE2) in tall girls, who are treated with high dosages of this estrogen. Interesting characteristics determined by (i) MS:

  4. Living Together: The Impact of the Intifada and the Peace Negotiations on Attitudes toward Coexistence of Arab and Jewish Pupils in Ethnically Segregated and Mixed Schools in Jaffa.

    Science.gov (United States)

    Zuzovsky, Ruth

    1997-01-01

    Changes in the willingness of Jews and Arabs to coexist were studied in 1989 with 217 12-year-olds and in 1994 with 194 in Jaffa (Israel), where both Jews and Arabs live. Separatist attitudes increased and faith in coexistence decreased, but mixed schools seemed to improve attitudes toward coexistence. (SLD)

  5. Decision Under Conflict: Resolution and Confidence in Judgment and Choice

    Science.gov (United States)

    1992-08-05

    specifically, by an overpricing of the low probability bet (see Tversky, Slovic, & Kahneman, "The causes of preference reversal," American Economic Review , 1990...preference reversal. American Economic Review ,, 80, 204-217. Tversky, A., & Thaler, R. (1990). Anomalies: Preference reversals. Journal of Economic Perspectives, 4(2), 201-2111.

  6. Shyness and Love on a College Campus.

    Science.gov (United States)

    Maroldo, Georgette K.

    1982-01-01

    Shyness and love scales were administered to 153 men and 217 women at Texas Lutheran College. Love, dating, and friendship groups were identified on the love scale with respect, congeniality, altruism, physical attraction, and attachment subscales. For the love and friendship groups, shyness appears to be a barrier. (Author/CM)

  7. Radiation damage of laser materials. Citations from the NTIS data base

    Science.gov (United States)

    Carrigan, B.

    1980-05-01

    Laser beam damage to laser materials such as optical glass, glass fibers, alkali metal halides, metals, mirrors, optical coatings, dielectrics, semiconductors, and matrix materials is studied. The majority of these citations concern infrared laser damage to infrared optical materials. This updated bibliography contains 217 abstracts, 10 of which are new entries to the previous edition.

  8. EST Table: FS743436 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS743436 E_FL_bmmt_25K22_R_0 10/09/28 99 %/217 aa ref|NP_001040134.1| isocitrate de...3304|DanaGF10112-PA 10/08/28 78 %/215 aa F59B8.2#CE03436#WBGene00010317#locus:idh-1#isocitrate dehydrogenase

  9. Comparison of chloroquine with artesunate in the treatment of cerebral malaria in Ghanaian children

    DEFF Research Database (Denmark)

    Goka, B Q; Adabayeri, V; Ofori-Adjei, E;

    2001-01-01

    and neurological deficits were documented. There was no difference in mortality rates (chloroquine, 16.7 per cent; artesunate, 21.7 per cent; p = 0.6), neurological deficit at day 14 (chloroquine, 0 per cent; artesunate, 4.3 per cent; p = 0.3), resolution of fever (p = 0.55), and coma recovery time (p = 0...

  10. Atorvastatin affects low density lipoprotein and non-high density lipoprotein cholesterol relations with apolipoprotein B in type 2 diabetes mellitus: modification by triglycerides and cholesteryl ester transfer protein

    NARCIS (Netherlands)

    P.J.W.H. Kappelle; L. Zwang; M.V. Huisman; J.D. Banga; W.J. Sluiter; G.M. Dallinga-Thie; R.P.F. Dullaart

    2009-01-01

    Objectives: Non-HDL-cholesterol (non-HDL-C) and apolipoprotein (apo) B are proposed as treatment targets. The extent to which statin therapy affects relationships of LDL-C and non-HDL-C with apoB was examined in type 2 diabetes. Methods: Analyses were performed in 217 hypertriglyceridaemic type 2 di

  11. Middle Eastern Geographies of World War I

    Science.gov (United States)

    2010-05-21

    retain.131 Soon after the fall of Basra, Sir Percy Cox, Chief Political Officer to the campaign, and Lord Hardinge, the Viceroy of India, both made...34Why Geography Matters ... But So Little is Learned." Orbis 47, no. 2 (Spring 2003): 217- 233. McFate, Montgomery, and Andrea Jackson . "An

  12. Compilation of Fall 1974 Goals, Subgoals and Priorities Meeting Goals Collection Criteria.

    Science.gov (United States)

    Systems Planning Corp., Sacramento, CA.

    California school districts reported their goals, subgoals, and priorities by matching statements to those in a catalog of 279 possible educational goals developed by a state legislature subcommittee. This report compiles data collected from 217 school districts that met certain goals collection criteria. Data from the remaining 614 participating…

  13. EST Table: D49476 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available D49476 10/09/29 100 %/220 aa dbj|BAF76331.1| ecdysone receptor [Bombyx mori] 10/09/...3:38907568:1|gene:AGAP012211 10/09/10 61 %/217 aa gnl|Amel|GB30298-PB 10/09/10 61 %/216 aa gi|121308146|emb|CAL25730.1| ecdyson

  14. Annual Report of the Chief of Engineers, U.S. Army, on Civil Works Activities 1959

    Science.gov (United States)

    1959-01-01

    1, 460 Mount Vernon , Ind__ ---- ------------------- -4, 699, 217 Bodega Bay, Calif--------------- ---------------------------- 2, 050 Crescent City...Jones River, Del Smyrna River, Del.2- - - - Back Creek (Anne Arundel County, Md.) ... Broad Creek, Somerset County, Md Broadwater Creek, Md Cadle Creek...Md___ Neale Sound, Md__ Northeast River, Md__ Parish Creek, Md__ Patuxent River, Md_ Pocomoke River, Md_ Rhodes Point to Tylerton, Somerset County

  15. The Relationships among Unethical Computer Usage Behavior and Some Personality Characteristics of Turkish University Students

    Science.gov (United States)

    Ceyhan, A. Aykut; Ceyhan, Esra

    2007-01-01

    This research aims at examining the relationships among unethical computer usage behavior and the personality characteristics of locus of control, adjustment to social norms, antisocial tendency, and aggression on Turkish university students. The research was applied to 217 university students. Data were collected through Unethical Computer Using…

  16. Planck 2013 results. VI. High Frequency Instrument data processing

    DEFF Research Database (Denmark)

    Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.;

    2013-01-01

    We describe the processing of the 531 billion raw data samples from the High Frequency Instrument (HFI), which we performed to produce six temperature maps from the first 473 days of Planck-HFI survey data. These maps provide an accurate rendition of the sky emission at 100, 143,217, 353, 545, an...

  17. Planck early results. IV. First assessment of the High Frequency Instrument in-flight performance

    DEFF Research Database (Denmark)

    Bréelle, E.; Bucher, M.; Cressiot, C.;

    2011-01-01

    The Planck High Frequency Instrument (HFI) is designed to measure the temperature and polarization anisotropies of the cosmic microwave background and Galactic foregrounds in six ~30% bands centered at 100, 143, 217, 353, 545, and 857 GHz at an angular resolution of 10′ (100 GHz), 7′ (143 GHz), a...

  18. Thermodynamics around the first-order ferromagnetic phase transition of Fe2P single crystals

    NARCIS (Netherlands)

    Hudl, M.; Campanini, D.; Caron, L.; Höglin, V.; Sahlberg, M.; Nordblad, P.; Rydh, A.

    2014-01-01

    The specific heat and thermodynamics of Fe2P single crystals around the first-order paramagnetic to ferromagnetic (FM) phase transition at TC≃217K are empirically investigated. The magnitude and direction of the magnetic field relative to the crystal axes govern the derived H−T phase diagram. Striki

  19. AcEST: DK951397 [AcEST

    Lifescience Database Archive (English)

    Full Text Available aracterized protein YNL018C OS=Saccharo... 33 1.9 sp|Q11EU7|METE_MESSB 5-methyltetrahydropteroyltriglutamate... Sbjct: 217 PPHSPHI 223 >sp|Q11EU7|METE_MESSB 5-methyltetrahydropteroyltriglutama

  20. Vaccine Risk/Benefit Communication: Effect of an Educational Package for Public Health Nurses

    Science.gov (United States)

    Davis, Terry C.; Fredrickson, Doren D.; Kennen, Estela M.; Humiston, Sharon G.; Arnold, Connie L.; Quinlin, Mackey S.; Bocchini, Joseph A., Jr.

    2006-01-01

    The purpose of this study was to determine whether an in-service for public health nurses (PHNs) and accompanying educational materials could improve vaccine risk/benefit communication. The content and timing of vaccine communication were recorded during 246 pre-and 217 post-intervention visits in two public health immunization clinics.…

  1. Development of a ROTC/Army Career Commitment Model. Volume 1

    Science.gov (United States)

    1975-11-01

    respect to demographic differences, a greater proportion of cadets come from military familias and from families that moved around 3 lot vhile the student...Sophomore Perceived Loss of Persona • Control and Individuality .27 .05 Willingness to join ROTC without fin ncial benefits (Item IV-U)g 2.17 2.54 Note

  2. Analysis of natural isolates of Lactobacilli resistant to bacteriocin nisin

    Directory of Open Access Journals (Sweden)

    Strahinić Ivana D.

    2005-01-01

    Full Text Available The collection of lactic acid bacteria (LAB was made by isolation of microorganisms from fermented products traditionally manufactured in different geographical regions (high mountains, river valleys, seaside, etc. Among collected LAB, 51 isolates were identified as Lactobacillus sp. Results showed that all isolated lactobacilli were mesophilic strains, since they grew at 15°C and 30°C but not at 45°C. Testing the ability of isolated lactobacilli to grow in the presence of nisin revealed that Lactobacillus sp. isolates designed BGCGK4, BGHN40, BGBUK2-8, BGBUK2-7 and BGBUK2-16 were resistant to nisin. Determination of the minimal inhibitory concentrations (MIC for nisin revealed that the most resistant isolate was Lactobacillus sp. BGCGK4. Isolate BGBUK2-16, determined as Lactobacillus paracasei subsp. paracasei, produces bacteriocin, named Bac217 and showed a resistance to 8000 IU/ml of nisin. Plasmid curing of BGBUK2-16 resulted in derivatives BGBUK2-16/K2 and BGBUK2-16/K4. Derivative BGBUK2-16/K2 retained resistance to Bac217 and nisin, but lost the ability to synthesise Bac217. Derivative BGBUK2-16/K4 lost concomitantly the resistance to both Bac217 and nisin.

  3. Cabazitaxel:a new drug for metastatic prostate cancer

    Institute of Scientific and Technical Information of China (English)

    Marijo Bilusic; William L Dahut

    2011-01-01

    @@ In Western countries, prostate cancer is the most common malignancy in men and ranks third in mortality.In 2010, an esti-mated 217 730 new cases are anticipated in the United States, and about 32 050 men are expected to die from the disease.

  4. Feelings of Well-Being Before and After an Abortion.

    Science.gov (United States)

    Hittner, Amy

    1987-01-01

    Examined feelings of well-being in 217 women who had abortions. Results suggest that, compared to women who have not had abortions, those who choose abortion feel more negatively. Of women choosing abortion, those who are already mothers are most likely to be depressed and lonely, followed by those from lower educational and socioeconomic…

  5. EST Table: FS726650 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS726650 E_FL_bmmt_08B23_F_0 10/09/28 100 %/205 aa ref|NP_001136399.1| kynureninase... [Bombyx mori] dbj|BAH03383.1| kynureninase [Bombyx mori] 10/09/03 n.h 10/08/28 33 %/217 aa C15H9.7#CE06835#WBGene00015802#kynure

  6. Spreading Depolarizations of Cerebral Cortex After Brain Injury: Mechanism of Injury Progression and Relevance to Military Neurotrauma

    Science.gov (United States)

    2006-11-01

    withdrawal of the strip by gentle traction (Fig. 1; Strong et al., 2002). Insofar as possible, the strip was placed along a single gyrus radiating...insulin was given sub- cutaneously beginning 71 hr post-injury when glucose reached 212 mg/dL. PO2 was 217-273 mmHg through 47 hr post- injury, 92-148

  7. FORMULASI DAN STABILITAS MIKROEMULSI O/W DENGAN METODE EMULSIFIKASI SPONTAN MENGGUNAKAN VCO DAN MINYAK SAWIT SEBAGAI FASE MINYAK: PENGARUH RASIO SURFAKTAN-MINYAK

    Directory of Open Access Journals (Sweden)

    Setyaningrum Ariviani

    2015-05-01

    Mikroemulsi tersebut memiliki distribusi ukuran partikel monomodal, rerata diameter partikel dan viskositas mencapai 21,7 ± 0,02nm dan 6,0 ± 0,10cp (VCO, 22,9 ± 0,15nm dan 6,2 ± 0,05cp (minyak sawit. Kata kunci: Mikroemulsi, formulasi, stabilitas, surfaktan minyak

  8. "Fugitive without Knowing It": Language, Displacement and Identity in Assia Djebar's Autobiographic Narratives

    Science.gov (United States)

    Ben Salem, Lobna

    2015-01-01

    If in Edward Said's words, "everyone lives life in a given language; everyone's experiences therefore are had, absorbed, and recalled in that language" ("Out of Place", 1999: 217), a writer who chooses to write in a language other than the mother-language is inevitably a victim of displacement. In a geography-decentred world,…

  9. Construct Validation of a Measure to Assess Sustainability of School-Wide Behavior Interventions

    Science.gov (United States)

    Hume, Amanda; McIntosh, Kent

    2013-01-01

    This study assessed aspects of construct validity of the School-wide Universal Behavior Sustainability Index-School Teams (SUBSIST), a measure evaluating critical features of the school context related to sustainability of school-wide interventions. Participants at 217 schools implementing School-wide Positive Behavior Support (SWPBS) were…

  10. Sisters in the Struggle: African American Female Graduate Students Coping with Racism and Racism-Related

    Science.gov (United States)

    Foster, Kelsie

    2013-01-01

    This study examined if coping was predictive of perceived racism and racism related stress of African American female graduate students. Participants were 217 African American female graduate students attending Predominantly White Institutions (PWIs), Hispanic Serving Institutions (HSIs) and Historically Black Colleges and Universities (HBCUs) and…

  11. Flight Testing of Night Vision Systems in Rotorcraft (Test en vol de systemes de vision nocturne a bord des aeronefs a voilure tournante)

    Science.gov (United States)

    2007-07-01

    it is advised to consult a Physicist/Electro-Optics expert to measure these values in situ (see also Lupo , 1972). 3.1.5 Measuring Modulation...flight procedures. Air Force Manual 11-217, Volume 2, Issue 6. [29] Lupo , J.C. (1972). The theory and measurement of the signal-to-noise ratio of

  12. Predicting mobility outcome one year after stroke: a prospective cohort study.

    NARCIS (Netherlands)

    Port, I.G. van de; Kwakkel, G.; Schepers, V.P.; Lindeman, E.

    2006-01-01

    OBJECTIVE: To develop a prognostic model to predict mobility outcome one year post-stroke. DESIGN: Prospective cohort study in patients with a first-ever stroke admitted for inpatient rehabilitation. PATIENTS: A total of 217 patients with stroke (mean age 58 years) following inpatient rehabilitation

  13. Partial Thermodynamic Properties of gamma-(Ni,Pt)3Al in the Ni-Al-Pt System (Preprint)

    Science.gov (United States)

    2006-02-01

    phases belonging to the Cu family, Journal of Alloys and Compounds , 353, 2003, 207. 4. J. Kamm, W. Milligan, Phase stability in (Ni, Pt)3Al alloys...in the Al-Ni-Ru system by direct reaction synthesis calorimetry, Journal of Alloys and Compounds , 403(1-2), 2005, 217-222. 15 Tables Table 1

  14. Journal of Clinical Monitoring and Computing 2015 end of year summary : tissue oxygenation and microcirculation

    NARCIS (Netherlands)

    Scheeren, T W L

    2016-01-01

    Last year we started this series of end of year summaries of papers published in the 2014 issues of the Journal Of Clinical Monitoring And Computing with a review on near infrared spectroscopy (Scheeren et al. in J Clin Monit Comput 29(2):217-220, 2015). This year we will broaden the scope and inclu

  15. Urn Automata

    Science.gov (United States)

    2003-11-05

    of deadlock or loss of synchronization. The Chemical Abstract Machine of Berry and Boudol [1] is an abstract machine designed to model a situation in...only small growth in the number of tokens? References [1] G. Berry and G. Boudol. The chemical abstract machine. Theoretical Computer Science, 96:217

  16. Computation in Networks of Passively Mobile Finite-State Sensors

    Science.gov (United States)

    2004-02-23

    in the case of conjugating automata. The Chemical Abstract Machine of Berry and Boudol [2] is an abstract machine designed to model a situation in...2003. [2] G. Berry and G. Boudol. The Chemical Abstract Machine. Theoretical Computer Science, 96:217–248, 1992. [3] D. Brand and P. Zafiropulo. On

  17. Politikberatung aus den Staatswissenschaften = Riigiteadus poliitikanõustajana / Jürgen Backhaus

    Index Scriptorium Estoniae

    Backhaus, Jürgen

    2005-01-01

    Teadmistepõhine poliitika eeldab, et teadmised, millele poliitika peab tuginema, on tõepoolest ka olemas ja et on olemas keegi, kes oskab neid poliitikuile efektiivselt edastada. Sotsiaalteaduste puhul kerkib esile probleem, et vastav kommunikatsioon on üha puudulikum, leiab autor. Vt. ka kommentaare lk. 217-222,467-472

  18. Tartu biomeditsiiniettevõtluse võimalused ja riiklikud poliitikad = Über die Möglichkeiten von Biomedizin-Unternehmen in Tartu und die staatliche Politik / Garri Raagmaa

    Index Scriptorium Estoniae

    Raagmaa, Garri, 1966-

    2005-01-01

    Teadmistepõhisest majandusest on küll palju räägitud, kuid selle sisu on jätkuvalt segane ja seetõttu ähvardab devalveeruda. Autori hinnangul on vaja enam kommunikatsiooni ning vastastikku arusaamist teadlaste, poliitikute ja ettevõtjate vahel. Vt. ka kommentaare lk. 217-222,467-472

  19. 78 FR 20913 - Information Collection(s) Being Submitted for Review and Approval to the Office of Management and...

    Science.gov (United States)

    2013-04-08

    ... recordkeeping and/or reporting requirements for holders of commercial radio licenses, as well as for Commercial Operator License Examination Managers (COLEM(s)) that administer commercial radio operator license.... Title: Sections 13.9(c), 13.13(c), 13.17(b), 13.211(e) and 13.217, Commercial Operator...

  20. 77 FR 24415 - Inflation Adjustment of the Aggravated Maximum Civil Monetary Penalty for a Violation of a...

    Science.gov (United States)

    2012-04-24

    ... Federal Railroad Administration 49 CFR Parts 209, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223...); 49 CFR 240.223(a), (b). Further, FRA is revising language in 49 CFR part 209, appendix A, ``Statement..., Transportation. 49 CFR Part 220 Communications, Penalties, Radio, Railroad safety, Reporting and...

  1. 47 CFR 73.623 - DTV applications and changes to DTV allotments.

    Science.gov (United States)

    2010-10-01

    .... 73.623 Section 73.623 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Television Broadcast Stations § 73.623 DTV applications and changes to... km. Zone II & III: 223.7 km. Co-channel, DTV to analog TV Zone I: 217.3 km. Zone II & III: 244.6...

  2. Vapor Phase Self-assembled Monolayers for Anti-stiction Applications in MEMS

    DEFF Research Database (Denmark)

    Zhuang, Yanxin; Hansen, Ole; Knieling, Thomas

    2007-01-01

    (CF2)7(CH2)2SiCl3 (FDTS), and CH3(CH2)17(CH2)2SiCl3 (OTS). The SAM coatings that were grown on silicon substrates were characterized with respect to static contact angle, surface energy, roughness, nanoscale adhesive force, nanoscale friction force, and thermal stability. The best overall anti...

  3. Mathematics Achievement as a Function of within- and between-School Differences

    Science.gov (United States)

    Mohammadpour, Ebrahim; Abdul Ghafar, Mohamed Najib

    2014-01-01

    Achievement in mathematics of eighth-grade students is modeled as a function of within-school, between-school and cross-country differences. The data were obtained from 217,728 students, within 7,216 secondary schools, in 48 countries, who participated in the 2007 Trends in International Mathematics and Science Study. Multilevel analysis showed…

  4. 78 FR 14516 - Notice of Availability of Government-Owned Inventions; Available for Licensing

    Science.gov (United States)

    2013-03-06

    ... IMAGE CORRELATION//U.S. Patent No. 8,217,318: SUBMERSIBLE HAND WARMER//U.S. Patent No. 8,226,042: SPIN...: HYDROSTATIC FORCE/DISPLACEMENT MEASURING DEVICE//U.S. Patent No. 8,326,081: CORRELATION IMAGE DETECTOR//U.S... City Division, 110 Vernon Ave., Panama City, FL 32407-7001. FOR FURTHER INFORMATION CONTACT: Mr....

  5. 78 FR 36098 - Final Flood Elevation Determinations

    Science.gov (United States)

    2013-06-17

    ... 510 North Broadway, 4th Floor, Billings, MT 59101. Unincorporated Areas of Yellowstone County Maps are available for inspection at 217 North 27th Street, Billings, MT 59101. (Catalog of Federal Domestic... 12866 of September 30, 1993, Regulatory Planning and Review, 58 FR 51735. Executive Order...

  6. Respiratory tract tumor

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    2010336 Study on the association between DNA double-strand break repair gene NBS1 polymorphisms and susceptibility on lung cancer. FAN Lihui(樊丽辉),et al. Dept Epidemiol,Public Health Sch,Fujian Med Univ,Fuzhou 350004.Chin J Epidemiol 2010;31(2):213-217.

  7. 77 FR 41781 - City of Quincy; FFP Project 109, LLC; Notice of Competing Preliminary Permit Applications...

    Science.gov (United States)

    2012-07-16

    ... Energy Regulatory Commission City of Quincy; FFP Project 109, LLC; Notice of Competing Preliminary Permit... May 1, 2012, City of Quincy and FFP Project 109, LLC filed preliminary permit applications pursuant to...: Mr. Charles Bevelheimer, 730 Maine Street, Quincy, IL 62301; (217) 228-4500. FFP Project 109,...

  8. 77 FR 41782 - City of Quincy; FFP Project 110, LLC; Notice of Competing Preliminary Permit Applications...

    Science.gov (United States)

    2012-07-16

    ... Energy Regulatory Commission City of Quincy; FFP Project 110, LLC; Notice of Competing Preliminary Permit... May 1, 2012, City of Quincy and FFP Project 110, LLC filed preliminary permit applications pursuant to... 62301; (217) 228-4500. FFP Project 110, LLC's proposed project would consist of: (1) Fourteen new...

  9. 76 FR 66044 - 36(b)(1) Arms Sales Notification

    Science.gov (United States)

    2011-10-25

    ... contractor engineering and logistics personnel support services, and other related elements of logistics... logistics personnel support services, and other related elements of logistics support. The estimated cost is... ALQ-217 Electronic Support Measure Systems. In addition, this proposed sale will include related...

  10. 76 FR 40701 - 36(b)(1) Arms Sales Notification

    Science.gov (United States)

    2011-07-11

    ... technical and logistics support services, tools and test equipment, and other related elements of logistics... equipment, U.S. Government and contractor technical and logistics support services, tools and test equipment, and other related elements of logistics support. The estimated cost is $217 million. This...

  11. 75 FR 38980 - Certain Cased Pencils From the People's Republic of China: Final Results of the Antidumping Duty...

    Science.gov (United States)

    2010-07-07

    ...), pastels, charcoals, chalks, and pencils produced under U.S. patent number 6,217,242, from paper infused with scents by the means covered in the above-referenced patent, thereby having odors distinct from... May 28, 2010. \\1\\ ``Pencil Industry in India--A Robust Future,'' Divya Jha, in ``Paper &...

  12. Belief in a JustWorld, Causal Attributions, and Adjustment to Sexual Violence

    NARCIS (Netherlands)

    Fetchenhauer, Detlef; Jacobs, Gabriele; Belschak, Frank

    2005-01-01

    What influence do the personal belief in a just world (i.e., the perception that one usually gets what one deserves) and different kinds of causal attributions have on adjustment to sexual violence? Using a sample of N = 62 victims of sexual aggression (mean age = 21.7) it was shown that respondents

  13. Recorrido de un artista plástico

    Directory of Open Access Journals (Sweden)

    Carlos Barreiro Ortiz

    2014-03-01

    Full Text Available Hiper/ultra/neo/post: Miguel Ángel Rojas, 30 años de arte en Colombia. Santiago Rueda. Instituto Distrital de Cultura y Turismo, Alcaldía Mayor de Bogotá, Bogotá, Colección de ensayos sobre el campo del arte, Ensayos de autor, 2005, 217 págs.

  14. Fetal cell detection in maternal blood : A study in 236 samples using erythroblast morphology, DAB and HbF staining, and FISH analysis

    NARCIS (Netherlands)

    Oosterwijk, JC; Mesker, WE; Ouwerkerk-van Velzen, MCM; Knepfle, CFHM; Wiesmeijer, KC; Beverstock, GC; van Ommen, GJB; Kanhai, HHH; Tanke, HJ

    1998-01-01

    A protocol to detect fetal nucleated red blood cells (NRBCs) was tested in 217 pregnant women and in 19 nonpregnant controls. All the pregnant women were sampled after chorionic villus sampling (CVS); 20 were also sampled pre-CVS. NRBC recognition was based upon morphology by using staining of hemog

  15. The Intergenerational Congruence of Mothers' and Preschoolers' Narrative Affective Content and Narrative Coherence

    Science.gov (United States)

    Sher-Censor, Efrat; Grey, Izabela; Yates, Tuppett M.

    2013-01-01

    Intergenerational congruence of mothers' and preschoolers' narratives about the mother-child relationship was examined in a sample of 198 Hispanic (59.1%), Black (19.2%), and White (21.7%) mothers and their preschool child. Mothers' narratives were obtained with the Five Minute Speech Sample and were coded for negative and positive affective…

  16. AcEST: DK962549 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YTS Sbjct: 80 QHRAGVSPYTS 90 >tr|Q1R3T7|Q1R3T7_ECOUT Putative uncharacterized protein OS=Escherichia coli (strain UTI89 / UPEC...S=Escherichia coli (strain UTI89 / UPEC) GN=UTI89_C3718 PE=4 SV=1 Length = 80 Score = 88.2 bits (217), Expec

  17. Correlates of Kindergarten Adjustment: Temperament and Communicative Competence.

    Science.gov (United States)

    Skarpness, Lorie R.; Carson, David K.

    1987-01-01

    The kindergarten adjustment of 217 Caucasian children was measured in relation to their temperament and communicative competence. Both communicative competence and various dimensions of temperament accounted for a significant proportion of the variance in kindergarten adjustment among the children. (Author/BB)

  18. The Contribution of Personality Traits, Motivation, Academic Risk-Taking and Metacognition to the Creative Ability in Mathematics

    Science.gov (United States)

    Erbas, Ayhan Kursat; Bas, Selda

    2015-01-01

    The purpose of this study was to investigate the extent to which personality traits, motivation, academic risk-taking, and metacognition explain the mathematical creative ability of high school students. The participants were 217 9th-grade students that were exceptionally high achievers. The participants responded to a set of measures about…

  19. The Essential Elements of Successful Marriage and Family Therapy: A Modified Delphi Study.

    Science.gov (United States)

    White, Mark B.; Edwards, Scott A.; Russell, Candyce S.

    1997-01-01

    A panel of American Association of Marriage and Family Therapy approved supervisors generated 771 variables thought to be fundamental to positive marriage and family therapy (MFT) outcome, and rated 217 of these variables as very important to the successful outcome of MFT. The variables were collapsed into five categories and further condensed…

  20. A Content Analysis of School Anti-Bullying Policies: A Follow-Up after Six Years

    Science.gov (United States)

    Smith, Peter K.; Kupferberg, Allison; Mora-Merchan, Joaquin A.; Samara, Muthanna; Bosley, Sue; Osborn, Rob

    2012-01-01

    An analysis was undertaken of 217 English school anti-bullying policies, from 169 primary schools and 48 secondary schools, using a 34-item scoring scheme. Findings were compared with an analysis of 142 schools six years earlier. Overall schools in the current analysis had about 49% of the items in their policies, a modest increase over the…

  1. Comparison of Qinzhou bay wetland landscape information extraction by three methods

    Directory of Open Access Journals (Sweden)

    X. Chang

    2014-04-01

    and OO is 219 km2, 193.70 km2, 217.40 km2 respectively. The result indicates that SC is in the f irst place, followed by OO approach, and the third DT method when used to extract Qingzhou Bay coastal wetland.

  2. Herbal medicine use among Turkish patients with chronic diseases

    Directory of Open Access Journals (Sweden)

    Munevver Tulunay

    2015-09-01

    Conclusions: In this study herbal medicine use was found to be higher among patients who had been diagnosed with chronic diseases. Therefore physicians should be aware of herbal medicine usage of their patients and inform them about the effectivity and side effects of herbal medicines. [J Intercult Ethnopharmacol 2015; 4(3.000: 217-220

  3. 76 FR 7719 - Promoting Diversification of Ownership in the Broadcasting Services

    Science.gov (United States)

    2011-02-11

    ... adopted at 73 FR 28361, May 16, 2008, are effective on March 14, 2011. FOR FURTHER INFORMATION CONTACT... Docket Nos. 01-235, 01-317, 00-244; FCC 07-217, 73 FR 28361, May 16, 2008. Synopsis As required by the... hours and burden costs published in the Federal Register on October 13, 2010, 75 FR 62816 have...

  4. Securing tropical forest carbon: the contribution of protected areas to REDD

    DEFF Research Database (Denmark)

    Scharlemann, J.P.W.; Kapos, V.; Campbell, A.;

    2010-01-01

    Forest loss and degradation in the tropics contribute 6-17% of all greenhouse gas emissions. Protected areas cover 217.2 million ha (19.6%) of the world's humid tropical forests and contain c. 70.3 petagrams of carbon (Pg C) in biomass and soil to 1 m depth. Between 2000 and 2005, we estimate tha...

  5. Cessation of smoking after first-ever stroke: a follow-up study

    DEFF Research Database (Denmark)

    Bak, Søren; Sindrup, Søren Hein; Alslev, Torben;

    2002-01-01

    and at follow-up were included in the present study. Among 198 patients (38.7%) who were current smokers on admission, 43 patients (21.7%) gave up smoking within 6 months of suffering a stroke. Sex, functional status, and sociodemographic characteristics were independently associated with persistent smoking...

  6. Downward Spirals, Boiled Frogs, and Catastrophes: Examining the Rate of School Decline

    Science.gov (United States)

    Hochbein, Craig

    2012-01-01

    The purpose of this study is to determine the validity of common assumptions about the rate at which school decline manifests. From a population of 981 elementary schools in the state of Virginia, the author uses three operational definitions of school decline to identify samples of declining schools: Absolute (n = 217), Relational (n = 510), and…

  7. 49 CFR 218.22 - Utility employee.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Utility employee. 218.22 Section 218.22... employee. (a) A utility employee shall be subject to the Hours of Service Act, and the requirements for... parts 217, 219, and 228 of this chapter. (b) A utility employee shall perform service as a member...

  8. Phenotypic variation in the Snowtrout Schizothorax richardsonii (Gray, 1832) (Actinopterygii: Cypriniformes: Cyprinidae) from the Indian Himalayas

    NARCIS (Netherlands)

    Mir, F.A.; Mir, J.I.; Chandra, S.

    2013-01-01

    We investigated intraspecific variation of the Snowtrout, Schizothorax richardsonii on the basis of morphometric characters. Altogether, 217 specimens were collected from four rivers in the Western and Central Indian Himalaya. A truss network was constructed by interconnecting 14 landmarks to yield

  9. Multi-Level Reconstruction of Visual Surfaces: Variational Principles and Finite Element Representations,

    Science.gov (United States)

    1982-04-01

    theory of edge detection which...Cohn.Vossen, S., [1952] Geometry and the Imagination, Chelsea, New York. f: Hildreth, E.C., 119801 Implementation of a theory of edge detection , MIT Al...Freeman, San Fransisco, CA. Marr, D., and Hildreth, E.C., [1980] " Theory of edge detection ," Proc. R. Soc. Lond. B, 207, 187-217. Mare, D., and

  10. On Edge Detection,

    Science.gov (United States)

    1984-08-01

    T. 0. "On boundary detection." A. I. Memo 183, MIT, 1980. Hildreth, E. C. "Implementation of a theory of edge detection ." A. /. Memo 579, MIT, 1980...Detection." IEEE Trans. PAMI, 6, 678-680, 1983. Marr, 0. C. and Hildreth, E. C, " Theory of edge detection ." Proc. R. Soc. Lond. B, 207, 187-217, 1980. Marr

  11. Ill-Posed Problems and Regularization Analysis in Early Vision,

    Science.gov (United States)

    1984-04-01

    Differential Equations, Yale University Press, New Haven, 1923. Hildreth, E.C., "Implementation of a theory of edge detection ," S.M. Thesis, Department...E.C., " Theory of edge detection ", Proc. R. Soc. Lond. B, 207, 187-217, 1980. Marr. D. and Poggio, T. "Cooperative computation of stereo disparity

  12. Optical, Biochemical, and Molecular Characterization of New Bioluminescence Systems

    Science.gov (United States)

    2007-05-09

    cyanide and hydrogen peroxide are strong inhibitors (some of them being known as inhibitors of dehydrogenase/dehydratase activity) while phenylphenol ...effect Sulfanilamide C6H8N20 2S 125 Activator Anthrone C14 H 00 133 Activator Phenylphenol C12H100 202 Activator Sodium persulfate Na 20 8S 2 217

  13. 7 CFR 1767.19 - Liabilities and other credits.

    Science.gov (United States)

    2010-01-01

    ... membership with the offsetting credit to the appropriate accounts receivable, and to accounts payable for any..., Patronage Capital Payable. (See also Account 217, Retired Capital Credits-Gain.) 201.2Patronage Capital...).) 223Advances from Associated Companies A. This account shall include the face value of notes payable...

  14. VizieR Online Data Catalog: Transiting planets search Matlab/Octave source code (Ofir+, 2014)

    Science.gov (United States)

    Ofir, A.

    2014-01-01

    The Matlab/Octave source code for Optimal BLS is made available here. Detailed descriptions of all inputs and outputs are given by comment lines in the file. Note: Octave does not currently support parallel for loops ("parfor"). Octave users therefore need to change the "parfor" command (line 217 of OptimalBLS.m) to "for". (7 data files).

  15. Codependency: Clarifying the Construct.

    Science.gov (United States)

    Springer, Carrie A.; Britt, Thomas W.; Schlenker, Barry R.

    1998-01-01

    College students (N=217) completed questionnaires to examine associations between codependency, relationship quality, and personality characteristics. Codependency was associated with lower self-esteem and lower perception of interpersonal control. Codependency was also found to be associated with greater self-consciousness, social anxiety, and…

  16. 78 FR 78952 - Access by EPA Contractors to Information Claimed as Confidential Business Information (CBI...

    Science.gov (United States)

    2013-12-27

    ... Register Notice (77 FR 217, November 8, 2012, pp. 66977-66978), require access to CBI submitted to us under the Clean Air Act and in connection with the Mandatory Greenhouse Gas (GHG) Reporting Rule [40 CFR... the fuels used to operate them, and by encouraging travel choices that minimize emissions. In order...

  17. Prothrombotic coagulation defects and cardiovascular risk factors in young women with acute myocardial infarction

    NARCIS (Netherlands)

    Tanis, BC; Bloemenkamp, DGM; van den Bosch, MAAJ; Kemmeren, JM; Algra, A; van de Graaf, Y; Rosendaal, FR

    2003-01-01

    We investigated the effect of prothrombotic coagulation defects in combination with smoking and other conventional risk factors on the risk of myocardial infarction in young women. In 217 women with a first myocardial infarction before the age of 50 years and 763 healthy control women from a populat

  18. Gclust Server: 24174 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available d protein, binds eIF4E and inhibits cap-dependent translation, also functions independently of eIF4E to main...ated Sequences(217) Sequence length 632 Representative annotation eIF4E-associated protein, binds eIF4E and inhibits

  19. Dutch Anthropometry for Vehicle Design and Evaluation

    Science.gov (United States)

    2008-10-01

    Nederlands antropometrisch bestand (NedScan) en van lichaamsafmetingen van goedgekeurde K.L rekruten. De grenswaarden omvatten 95% van dat Nederlandse ...TNO Defence, Security and Safety Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek / Netherlands Organisation for Applied...parties E 2008 TNO 20090213220 fdl-of-d^ 2/17 Nederlandse antropometrie voor voertuigontwerp en -evaluaties Probleemstelling Thans staan we aan de

  20. Data of evolutionary structure change: 1ACPA-2DEGF [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1ACPA-2DEGF 1ACP 2DEG A F STIEERVKKIIGEQLGVKQEEVTNNASFVEDLGADSLDT...HH EEE EEEEEEE EEEEEEEEEE -------- 0 1ACP... A 1ACPA EEFDT-----EIP...ine> ARG CA 217 LYS CA 149 THR CA 172 1ACP... A 1ACPA ELVMALEEEFDT

  1. EST Table: FY002291 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY002291 bmov7h16 11/11/04 99 %/217 aa ref|NP_001037309.1| vitellogenin precursor [...s: Precursor dbj|BAA02444.1| vitellogenin precursor [Bombyx mori] dbj|BAA06397.1| vitellogenin [Bombyx mori]..._971398.1| PREDICTED: similar to vitellogenin [Tribolium castaneum] FS939370 bmov ...

  2. Value of endometrial thickness measurement for diagnosing focal intrauterine pathology in women without abnormal uterine bleeding

    DEFF Research Database (Denmark)

    Dreisler, E; Sorensen, S Stampe; Ibsen, P H;

    2009-01-01

    modulators (n = 2). Thus, 375 women without AUB were included (217 pre- and 158 postmenopausal). Receiver-operating characteristics (ROC) curves for endometrial thickness and focal lesion were analyzed. RESULTS: Focal intrauterine pathology was confirmed in 41 women (35 with polyps, five with submucosal...

  3. Русский стих : метрика системы стихосложения, просодия (генеративный подход) / Михаил Лотман

    Index Scriptorium Estoniae

    Лотман, Михаил, 1952-

    2000-01-01

    Russian verse: its metrics, versification systems, and prosody (generative synopsis). Lk. 217-218 ; Vene värss: meetrika, värsisüsteemid ja prosoodika (generatiivne ülevaade). Lk. 241. Üldisest värsimõõduteooriast ja selle rakendamisest vene värsile

  4. In Situ Corrosion and Heat Loss Assessment of Two Nonstandard Underground Heat Distribution System Piping Designs

    Science.gov (United States)

    2011-06-01

    Bldg. 213 Bldg. 215 Bldg. 218 Bldgs. 223, 225 Bldgs. 217, 224Bldgs. 216 Bldg 412 (New Clinic) Bldg. 440 ( Dental Clinic) VP-31 VP- 29 VP-33 Bldg. 258 (HQ...materials vary widely depending on the installation and include coal tar, fusion bonded epoxy, wax , tape, and asphalt. Further, the pipelines are

  5. 78 FR 76629 - The National Children's Study, Vanguard (Pilot) Study; Submission for OMB Review; 30-Day Comment...

    Science.gov (United States)

    2013-12-18

    ... Caregiver. ] Child-Focused Physical Child 1,217 2 9/60 365 Measures--Anthropometry, Blood Pressure, Vision... HUMAN SERVICES National Institutes of Health The National Children's Study, Vanguard (Pilot) Study; Submission for OMB Review; 30-Day Comment Request SUMMARY: In compliance with the requirement of Section...

  6. Resonant tunneling through the triple-humped fission barrier of U-236

    NARCIS (Netherlands)

    Csatlos, M; Krasznahorkay, A; Thirolf, PG; Habs, D; Eisermann, Y; Faestermann, T; Graw, G; Gulyas, J; Harakeh, MN; Hertenberger, R; Hunyadi, M; Maier, HJ; Mate, Z; Schaile, O; Wirth, HF

    2005-01-01

    The fission probability of U-236 as a function of the excitation energy has been measured with high energy resolution using the U-235(d, pf) reaction in order to study hyperdeformed (HD) rotational bands. Rotational band structures with a moment of inertia of theta = 217 +/- 38 h(2)/MeV have been ob

  7. Ozarenije, ili lesnitsa, vedushtshaja k ikone / Valentina Siig

    Index Scriptorium Estoniae

    Siig, Valentina

    2007-01-01

    Ikooninäitus "Õigeusklik ikoon Eestis" Vene kultuurikeskuse galeriis Tallinnas, eksponeeritud 18-20. sajandist 97 ikooni. Näituse külastatavusest. Ikoonimaalija Aleksandr Balajevi (1947) eluloost, maalitud ikoonidest. Ill. lk. 217 ja 219 kunstniku 7 ikooni

  8. Arbejdsmiljø i FØTEK-programmet

    DEFF Research Database (Denmark)

    Broberg, Ole; Hansen, Iben Posniak

    1997-01-01

    , and (ii) to put forward recommendations for improving the integration of ergonomics into joint projects sponsored by the FOETEK programme. A survey based on a questionnaire was conducted among 57 joint projects. A total of 217 project managers or contact persons received the questionnaire. The response...

  9. Examining the Clinical Correlates of Autism Spectrum Disorder in Youth by Ascertainment Source

    Science.gov (United States)

    Joshi, Gagan; Faraone, Stephen V.; Wozniak, Janet; Petty, Carter; Fried, Ronna; Galdo, Maribel; Furtak, Stephannie L.; McDermott, Katie; Epstien, Cecily; Walker, Rosemary; Caron, Ashley; Feinberg, Leah; Biederman, Joseph

    2014-01-01

    To examine whether presentation of autism spectrum disorder (ASD) and associated patterns of psychiatric comorbidity and dysfunction vary by referral source. ASD youth referred to a specialized ambulatory program for ASD (N = 143) were compared to ASD youth referred to a general child psychiatry clinic (N = 217). More ASD clinic youth met criteria…

  10. 47 CFR 15.215 - Additional provisions to the general radiated emission limitations.

    Science.gov (United States)

    2010-10-01

    ... RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission Limits, Additional Provisions § 15.215 Additional provisions to the general radiated emission limitations. (a) The regulations in §§ 15.217 through... frequency bands shown in these alternative provisions must be attenuated to the emission limits shown...

  11. Drug repositioning and repurposing: terminology and definitions in literature

    NARCIS (Netherlands)

    Langedijk, Joris; Mantel-Teeuwisse, Aukje K; Slijkerman, Diederick S; Schutjens, Marie-Hélène D B

    2015-01-01

    Drug repositioning and similar terms have been a trending topic in literature and represent novel drug development strategies. We analysed in a quantitative and qualitative manner how these terms were used and defined in the literature. In total, 217 articles referred to 'drug repositioning', 'drug

  12. Adaptive Profiles in Autism and Other Neurodevelopmental Disorders

    Science.gov (United States)

    Mouga, Susana; Almeida, Joana; Café, Cátia; Duque, Frederico; Oliveira, Guiomar

    2015-01-01

    We investigated the influence of specific autism spectrum disorder (ASD) deficits in learning adaptive behaviour, besides intelligence quotient (IQ). Participated 217 school-aged: ASD (N = 115), and other neurodevelopmental disorders (OND) groups (N = 102) matched by Full-Scale IQ. We compared standard scores of Vineland Adaptive Behaviour Scale…

  13. Psychological Impact of a Nuclear Power Plant: Changing Perceptions of Community and Neighborhood.

    Science.gov (United States)

    Hughey, Joseph B.

    1986-01-01

    Examines change in attitude toward community and descriptions of neighborhood environments of 217 residents of rural host community for a nuclear power plant. Finds negative attitude change and less positive descriptions of neighborhoods. Discusses implications for community psychology and preventive intervention. (LFL)

  14. Hopelessness and Suicidal Behavior among Chinese, Thai and Korean College Students and Predictive Effects of the World Health Organization's WHOQOL-BREF

    Science.gov (United States)

    Kay, Noy; Li, Kaigang; Xiao, Xia; Nokkaew, Nattiporn; Park, Bock-Hee

    2009-01-01

    The purpose of this study was to assess the current status of suicide behavior and to examine the association between hopeless feelings, suicidal behavior and components of the WHO Quality-of-Life-BREF instrument among college students (n = 1,217) in China, Thailand, and Korea. Results showed 3.7% Thai, 10% Chinese, and 13.2% Korean students…

  15. Komplikationer til langtidsbehandling med vitamin K-antagonister

    DEFF Research Database (Denmark)

    May, O; Garne, E; Mickley, H

    1990-01-01

    Long-term treatment with vitamin K antagonists (vKA) frequently involves complications. The commonest complication is haemorrhage and cases of serious haemorrhage are stated in the literature to occur with a frequency per 1,000 treatment years of 12-108, of which 2-17 are fatal. The majority...

  16. Differences in injury risk and characteristics between Dutch amateur and professional soccer players

    NARCIS (Netherlands)

    Beijsterveldt, A.M.C. van; Stubbe, J.H.; Schmikli, S.L.; Port, I.G.L. van de; Backx, F.J.G.

    2015-01-01

    Objectives: To compare the incidence and characteristics of injuries between Dutch amateur and professional male soccer players during one entire competition season. Design: A prospective two-cohort design. Methods: During the 2009-2010 season, 456 Dutch male amateur soccer players and 217 professio

  17. Dirac fermions in strong gravitational fields

    OpenAIRE

    Silenko, A. J.

    2013-01-01

    arXiv publications (http://lanl.arxiv.org) arXiv:1308.2610 Comments: 9 pages Journal-ref: JETP Letters 98, 217 (2013) Subjects: High Energy Physics - Experiment (hep-ex); Accelerator Physics (physics.acc-ph); Atomic Physics (physics.atom-ph)

  18. 75 FR 69165 - Conductor Certification

    Science.gov (United States)

    2010-11-10

    ... From the Federal Register Online via the Government Publishing Office ] Part II Department of Transportation Federal Railroad Administration 49 CFR Part 242 Conductor Certification; Proposed Rule #0;#0;Federal Register / Vol. 75, No. 217 / Wednesday, November 10, 2010 / Proposed Rules#0;#0; ] DEPARTMENT...

  19. Predictors of Changes in Body Image Concerns of Chinese Adolescents

    Science.gov (United States)

    Chen, Hong; Jackson, Todd

    2009-01-01

    This nine-month prospective study tested the extent to which risk factors implicated in recent accounts of body dissatisfaction predicted changes in body image concerns of adolescent boys and girls in China. A sample of 593 Chinese adolescents (217 boys, 376 girls) completed measures of weight esteem, appearance esteem and physical stature concern…

  20. 75 FR 47701 - Electronic System for Travel Authorization (ESTA): Travel Promotion Fee and Fee for Use of the...

    Science.gov (United States)

    2010-08-09

    ... SECURITY U.S. Customs and Border Protection 8 CFR Part 217 RIN 1651-AA83 Electronic System for Travel Authorization (ESTA): Travel Promotion Fee and Fee for Use of the System AGENCY: U.S. Customs and Border... Visa Waiver Program to Implement the Electronic System for Travel Authorization.'' U.S. Customs...