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Sample records for astatine 207

  1. Organic chemistry of astatine

    International Nuclear Information System (INIS)

    The paper surveys the investigations on the chemical behaviour of astatine in organic systems and deals with the preparation and identification of its organic compounds. A discussion is given on some of the physico-chemical properties of these compounds determined by extrapolation techniques as well as by direct measurement. The biomedical importance of 211At-labelled compounds is briefly referred to. (authors)

  2. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  3. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. Dosimetrical considerations in astatine-211 radioimmunotherapy

    International Nuclear Information System (INIS)

    Several dosimetrical quantities have been suggested for use in alpha-particle dosimetry. To evaluate the expected biological effect when using these quantities, a Monte Carlo program was set to register the single-event distribution of both specific energy and alpha-particle track length to a cell nucleus (r=5.6 μm). Distributions were acquired for both 'bound' (simulating the effect of 211At-labelled antibodies bound to antigens on cell surfaces (r=7.0 μm)) as well as 'non-bound' (simulating 211At-labelled antibodies that have not bound to a cell) astatine-211. From these distributions, various theoretical cell survival curves were established for 3 different dosimetrical quantities, i.e. specific energy, number of alpha-particle hits and total track length. The survival curves for all quantities are presented for the corresponding mean absorbed dose in order to facilitate comparisons of the expected effects of using the 3 different quantities for both distributions of 211At decays. The theoretical survival curves presented here could, combined with experiments using 'bound' and 'non-bound' 211At in a single-cell suspension, reveal which dosimetrical quantity is most suitable for 211 At-radioimmunotherapy. (author)

  6. Discovery of the astatine, radon, francium, and radium isotopes

    OpenAIRE

    Fry, C; Thoennessen, M

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  7. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  8. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  9. Scrutinizing "Invisible" astatine: A challenge for modern density functionals.

    Science.gov (United States)

    Sergentu, Dumitru-Claudiu; David, Grégoire; Montavon, Gilles; Maurice, Rémi; Galland, Nicolas

    2016-06-01

    The main-group 6p elements did not receive much attention in the development of recent density functionals. In many cases it is still difficult to choose among the modern ones a relevant functional for various applications. Here, we illustrate the case of astatine species (At, Z = 85) and we report the first, and quite complete, benchmark study on several properties concerning such species. Insights on geometries, transition energies and thermodynamic properties of a set of 19 astatine species, for which reference experimental or theoretical data has been reported, are obtained with relativistic (two-component) density functional theory calculations. An extensive set of widely used functionals is employed. The hybrid meta-generalized gradient approximation (meta-GGA) PW6B95 functional is overall the best choice. It is worth noting that the range-separated HSE06 functional as well as the old and very popular B3LYP and PBE0 hybrid-GGAs appear to perform quite well too. Moreover, we found that astatine chemistry in solution can accurately be predicted using implicit solvent models, provided that specific parameters are used to build At cavities. © 2016 Wiley Periodicals, Inc. PMID:27059181

  10. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  11. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  12. At R207

    CERN Multimedia

    1976-01-01

    The photo shows the fast electronics racks of the experiment R207 by the CERN-Holland-Manchester Collaboration. R207 aimed at the study of diffraction dissociation and formation at small momentum transfers. Gerjan Bobbink and Alan Rudge stand in front of the racks.

  13. Astatine-211: production, injection into monoclonal antibodies radiological effect, possible application to cancer treatment

    International Nuclear Information System (INIS)

    Methods developed in the Laboratory of Nuclear Problems, JINR, for producing astatine-211 and injecting it into monoclonal antibodies are described. The use of its diethylene triamine penta-acetic acid complex is shown to be the most effective method of injecting astatine into a biomolecules. The biological effect of the α-particles emitted from the astatine-211 is investigated using Chinese hamster fibroblasts and Ehrlich carcinoma cells. It is established that the mitotic activity depression, number of degenerating cells, number of cells with chromosome aberrations, and cellular surviving fraction depend on the concentration of the radionuclide in the medium 'in vitro'. The RBE of α-particles in comparison with 60Co γ-rays is 3. Injection of astatine-211 absorbed on tellurium particles into mice with ascitic tumors resulted in prolongation of their life or elimination of the tumors. (author). 39 refs, 7 figs

  14. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  15. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    Science.gov (United States)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-07-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method that combines dry distillation of astatine-211 and a synthesis module for producing radiopharmaceuticals into a process platform. This platform will standardize production of astatinated radiopharmaceuticals, and hence, it will facilitate large clinical studies focused on this promising, but chemically challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies.

  16. 49 CFR 571.207 - Standard No. 207; Seating systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Standard No. 207; Seating systems. 571.207 Section... Motor Vehicle Safety Standards § 571.207 Standard No. 207; Seating systems. S1. Purpose and scope. This.... Definitions. Occupant seat means a seat that provides at least one designated seating position. Seat...

  17. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-01-01

    vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method......To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and...... challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies....

  18. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  19. SCI 207 UOP Tutorial Course / Uoptutorial

    OpenAIRE

    jamesband

    2015-01-01

    SCI 207 Week 1 DQ 1 Biomes and Diversity SCI 207 Week 1 DQ 2 Trends in the Environment SCI 207 Week 1 Assignment  Innovation and Sustainability SCI 207 Week 1 Laboratory Population Biology SCI 207 Week 2 DQ 1 Food and Agriculture SCI 207 Week 2 DQ 2 SCI 207 Week 2 Laboratory 2 Land Use in Pinchot SCI 207 Week 3 DQ 1 Water Cycle SCI 207 Week 3 DQ 2 Age of Oil SCI 207 Week 3 Assignment Final Paper Outline (Global Warming) SCI 207 Week 3 Quiz SCI ...

  20. At R207

    CERN Multimedia

    1975-01-01

    With R207 the CERN-Holland-Manchester Collaboration studied proton-proton diffraction dissociation at small momentum transfer. This followed, at Intersection 2, the study of correlations associated with high transverse momentum particles by Daresbury-Liverpool-RHEL Collaboration (R205) and of multiplicity and rapidity distributions in diffractive collisions by CERN-Holland-Lancaster-Manchester (R206), and used part of the previous set-up.

  1. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  2. SCI 207 UOP Tutorial course/ Uoptutorial

    OpenAIRE

    Paulo Coelho

    2015-01-01

    For more course tutorials visit www.uoptutorial.com     SCI 207 Week 1 DQ 1 Biomes and Diversity SCI 207 Week 1 DQ 2 Trends in the Environment SCI 207 Week 1 Assignment  Innovation and Sustainability SCI 207 Week 1 Laboratory Population Biology SCI 207 Week 2 DQ 1 Food and Agriculture SCI 207 Week 2 DQ 2 SCI 207 Week 2 Laboratory 2 Land Use in Pinchot SCI 207 Week 3 DQ 1 Water Cycle SCI 207 Week 3 DQ 2 Age of Oil SCI 207 Week ...

  3. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  4. At R207

    CERN Multimedia

    1975-01-01

    At the centre, a barrel shaped hodoscope surrounds the beams' crossing point. It was previously used for experiments R205 and R206 which did run in 1974. After their completion in mid 1975 the equipment of R205 was removed, and that of R206 was modified and rearranged to create two small angle spectrometers, one on each side of the intersection, for experiment R207 (diffraction dissociation and formation at small momentum transfer), by the CERN-Holland-Manchester Collaboration. (see also photos 7508109X and 7508113X) Here on the right, Lars Leistam.

  5. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  6. SCI 207 ASH Course Tutorial/Tutorialrank

    OpenAIRE

    DANIELCHARLI

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 6 Times, Rating: A   ASHFORD SCI 207 Week 1 DQ 1 Biomes and Diversity ASHFORD SCI 207 Week 1 DQ 2 Trends in the Environment ASHFORD SCI 207 Week 1 Assignment  Innovation and Sustainability ASHFORD SCI 207 Week 1 Laboratory Population Biology ASHFORD SCI 207 Week 2 DQ 1 Food and Agriculture ASHFORD SCI 207 Week 2 DQ 2 ASHFORD SCI 207 Week 2 Laboratory 2 Land Use in Pinchot A...

  7. Direct astatination of a tumour-binding protein, human epidermal growth factor, using nido-carborane as a prosthetic group

    International Nuclear Information System (INIS)

    A method for direct astatine labeling of proteins has been investigated. Binding sites for astatine were created by coupling of a nido-carborane derivative to a protein, the human epidermal growth factor (hEGF), using two different conjugation methods - by glutaraldehyde cross-linking or by introduction of sulfohydryl groups by Traut's reagent with subsequent linking of ANC-1 with m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester. The conjugates were astatinated using the Chloramine-T method in high yield. The best labeling was obtained by the glutaraldehyde conjugate with an average yield of 68 ± 9%. In vitro stability tests indicated that the glutaraldehyde conjugated label was as stable as hEGF labeled with astatobenzoate. (author)

  8. Excited States in 207Rn

    Institute of Scientific and Technical Information of China (English)

    罗万居; 郭应祥; 周小红; 张玉虎; 雷相国; 刘忠; 郑勇; 柳敏良; 何建军; 竺礼华; 温书贤

    2003-01-01

    Excited states in 207Rn are investigated via the 196Pt(16O,Sn)207Rn reaction at beam energies from 85 to 95 MeV using techniques of in-beam γ-ray spectroscopy. Measurements ofγ-ray excitation function, x - γ and γ - γ- t coincidences are performed with ten BGO(AC)HPGe detectors. Based on these measurements, a level scheme of207Rn, including 17 γ-rays and 18 levels, is established. Spins for most of the levels are proposed according to the measured DCO ratios. The level structure is compared with a weak-coupling calculation using the interaction energies extracted from neighbouring nuclei.

  9. Labelling prospects of astatine-211 with immunoglobulins (IgG): some general considerations

    International Nuclear Information System (INIS)

    The tumour therapeutic potential of the short lived alpha emitting radiohalogen 211At has been already been well recognised in the field of radioimmuno therapy. There is no evidence as such to show that astatine itself is a tumour seeking isotope. Therefore it has to be tagged to tumour seeking compound such as a drug or a protein preferably an antibody (IgG). In this communication, the labelling parameters which are required to be investigated for obtaining a stable product which could be useful as radioimmuno therapeutic agent, are described. (author). 6 refs

  10. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  11. Extraction of 211At-astatine from hydrochloric acid solutions by means of TOPO, TBP, and triphenylphosphine

    International Nuclear Information System (INIS)

    The extraction behaviour of astatine was studied under defined conditions from hydrochloride acid solutions (cHCl>0.1 M or 1 and 2M). Therefore other effects like adsorption, reduction or hydrolysis can be excluded. The present work describes the extraction with tri- n- octylphosphinoxide (TOPO), tri- n-butylphosphate (TBP) and tri-phenylphosphine in chloroform. (orig.)

  12. No-carrier-added astatination of N-succinimidyl-3-(tri-n-butylstannyl) benzoate (ATE) via electrophilic destannylation

    International Nuclear Information System (INIS)

    The no-carrier-added synthesis of N-succinimidyl 3-[211At]astato-benzoate from N-succinimidyl 3-(tri-n-butylstannyl)benzoate (ATE) is described. The nature of the solvent in which the 211At was isolated from the target was an important factor influencing both the radiochemical yields and the nature of the incorporated astatine activity. (orig.)

  13. 46 CFR 10.207 - Identification number.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Identification number. 10.207 Section 10.207 Shipping... CREDENTIAL General Requirements for All Merchant Mariner Credentials § 10.207 Identification number. For recordkeeping purposes only, a mariner's official MMC identification number is the individual's social...

  14. 20 CFR 345.207 - Defunct employer.

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    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Defunct employer. 345.207 Section 345.207... EMPLOYERS' CONTRIBUTIONS AND CONTRIBUTION REPORTS Individual Employer Records § 345.207 Defunct employer. If the Board determines that an employer has permanently ceased to pay compensation with respect to...

  15. 34 CFR 300.207 - Personnel development.

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    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Personnel development. 300.207 Section 300.207 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... CHILDREN WITH DISABILITIES Local Educational Agency Eligibility § 300.207 Personnel development. The...

  16. 40 CFR 59.207 - Test methods.

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    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Test methods. 59.207 Section 59.207 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Compound Emission Standards for Consumer Products § 59.207 Test methods. Each manufacturer or...

  17. 40 CFR 240.207-1 - Requirement.

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    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirement. 240.207-1 Section 240.207-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.207-1...

  18. 49 CFR 228.207 - Training.

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    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Training. 228.207 Section 228.207 Transportation... TRANSPORTATION HOURS OF SERVICE OF RAILROAD EMPLOYEES Electronic Recordkeeping § 228.207 Training. (a) In general. A railroad, or a contractor or subcontractor to a railroad, shall provide its train...

  19. 40 CFR 262.207 - Training.

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    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Training. 262.207 Section 262.207... Accumulation of Unwanted Material for Laboratories Owned by Eligible Academic Entities § 262.207 Training. An eligible academic entity must provide training to all individuals working in a laboratory at the...

  20. 5 CFR 630.207 - Travel time.

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    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Travel time. 630.207 Section 630.207... and General Provisions for Annual and Sick Leave § 630.207 Travel time. The travel time granted an... occupied in traveling to and from his post of duty and (a) the United States, or (b) his place of...

  1. 33 CFR 117.207 - Housatonic River.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Housatonic River. 117.207 Section 117.207 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.207 Housatonic River. (a) The...

  2. 7 CFR 62.207 - Official assessment.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Official assessment. 62.207 Section 62.207 Agriculture... Definitions Service § 62.207 Official assessment. Official assessment of an applicant's program shall include: (a) Documentation assessment. Auditors and other USDA officials shall review the applicant's...

  3. 42 CFR 59.207 - Payments.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Payments. 59.207 Section 59.207 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING SERVICES Grants for Family Planning Service Training § 59.207 Payments. The Secretary shall from time to time...

  4. 211At-Rh(16-S4-diol) complex as a precursor for astatine radiopharmaceuticals

    International Nuclear Information System (INIS)

    211At is one of the most promising radionuclides in α-radioimmunotherapy (α-RIT). Unfortunately, biomolecules labeled by direct electrophilic astatination are unstable due to the rapid loss of 211At under both in vitro and in vivo conditions. The present paper describes the results of our studies on attaching At- to the rhodium(III) complex with thioether ligand: 1,5,9,13-etrathiacyclohexadecane-3,11-diol (16-S4-diol). Rh3+ was chosen as a moderately soft metal cation which should form very strong bonds with soft At- anions, but first of all because of the kinetic inertness of low spin rhodium(III) d6 complexes. The 16-S4-diol ligand was selected due to formation of stable complexes with Rh3+. The experiments related to optimization of the reaction conditions were performed with the 131I, basing on a chemical similarity of I- to At-. The experiments with 211At were then carried out under the conditions found optimal for I-. The preliminary results are promising, and indicate a possibility for astatination of biomolecules by using the 211At-Rh(16-S4-diol) complex

  5. 14 CFR 417.207 - Trajectory analysis.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Trajectory analysis. 417.207 Section 417... OF TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.207 Trajectory analysis. (a) General. A flight safety analysis must include a trajectory analysis that establishes: (1) For any...

  6. 47 CFR 15.207 - Conducted limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Conducted limits. 15.207 Section 15.207... Conducted limits. (a) Except as shown in paragraphs (b) and (c) of this section, for an intentional radiator... to 30 MHz, shall not exceed the limits in the following table, as measured using a 50 μH/50 ohms...

  7. 24 CFR 570.207 - Ineligible activities.

    Science.gov (United States)

    2010-04-01

    ... construction equipment for use as part of a solid waste disposal facility is eligible under § 570.201(c). (ii... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Ineligible activities. 570.207 Section 570.207 Housing and Urban Development Regulations Relating to Housing and Urban...

  8. 44 CFR 207.4 - Responsibilities.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Responsibilities. 207.4... HOMELAND SECURITY DISASTER ASSISTANCE MANAGEMENT COSTS § 207.4 Responsibilities. (a) General. This section identifies key responsibilities of FEMA and grantees in carrying out section 324 of the Stafford Act, 42...

  9. 48 CFR 207.172 - Human research.

    Science.gov (United States)

    2010-10-01

    ... compliance with 32 CFR Part 219, Protection of Human Subjects; and (b) Must have a Human Research Protection... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Human research. 207.172... OF DEFENSE ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Plans 207.172 Human research. Any...

  10. 10 CFR 207.1 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Purpose. 207.1 Section 207.1 Energy DEPARTMENT OF ENERGY OIL COLLECTION OF INFORMATION Collection of Information Under the Energy Supply and Environmental... energy information which the Administrator is authorized to obtain by sections 11 (a) and (b) of...

  11. 40 CFR 86.207-94 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false 86.207-94 Section 86.207-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New Medium-Duty...

  12. 40 CFR 89.207 - Credit calculation.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Credit calculation. 89.207 Section 89... Trading Provisions § 89.207 Credit calculation. (a) Requirements for calculating NO X credits from Tier 1 engines rated at or above 37 kW. (1) For each participating engine family, emission credits (positive...

  13. 5 CFR 430.207 - Monitoring performance.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Monitoring performance. 430.207 Section 430.207 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERFORMANCE MANAGEMENT Performance Appraisal for General Schedule, Prevailing Rate, and Certain Other Employees §...

  14. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  15. Spectrophotometry of a BCG. IZW 207

    International Nuclear Information System (INIS)

    We present spectroscopic observations of the Blue Compact Galaxy IZW 207. It appears more similar to High Luminosity Galaxies in chemical abundances and infrared properties suggesting different histories of star formation in both

  16. 47 CFR 80.207 - Classes of emission.

    Science.gov (United States)

    2010-10-01

    ... Register citations affecting § 80.207, see the List of CFR Sections Affected, which appears in the Finding... 47 Telecommunication 5 2010-10-01 2010-10-01 false Classes of emission. 80.207 Section 80.207... MARITIME SERVICES General Technical Standards § 80.207 Classes of emission. (a) Authorization to...

  17. SCI 207 ash course tutorial/tutorial rank

    OpenAIRE

    manude

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 6 Times, Rating: A   ASHFORD SCI 207 Week 1 DQ 1 Biomes and Diversity ASHFORD SCI 207 Week 1 DQ 2 Trends in the Environment ASHFORD SCI 207 Week 1 Assignment  Innovation and Sustainability ASHFORD SCI 207 Week 1 Laboratory Population Biology ASHFORD SCI 207 Week 2 DQ 1 Food and Agriculture ASHFORD SCI 207 Week 2 DQ 2 ASHFORD SCI 207 Week 2 Laboratory 2 Land Use in Pinchot A...

  18. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  19. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  20. 24 CFR 207.259 - Insurance benefits.

    Science.gov (United States)

    2010-04-01

    ... insurance pursuant to 24 CFR parts 251, 252, or 255, the amount of the fee set forth through Federal... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Insurance benefits. 207.259 Section... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES...

  1. 48 CFR 12.207 - Contract type.

    Science.gov (United States)

    2010-10-01

    ....203-1). (e) Use of any contract type other than those authorized by this subpart to acquire commercial... ACQUISITION OF COMMERCIAL ITEMS Special Requirements for the Acquisition of Commercial Items 12.207 Contract... contracts or fixed-price contracts with economic price adjustment for the acquisition of commercial...

  2. 48 CFR 212.207 - Contract type.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE ACQUISITION PLANNING ACQUISITION OF COMMERCIAL ITEMS Special Requirements for the Acquisition of Commercial Items 212.207 Contract type. b) In accordance with Section 805 of the National... contracts for the acquisition of commercial items is authorized only for the following: (i)...

  3. 12 CFR 207.3 - CRA communications.

    Science.gov (United States)

    2010-01-01

    ... REPORTING OF CRA-RELATED AGREEMENTS (REGULATION G) § 207.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the following— (1) Any written or oral comment or testimony... contacts with a Federal banking agency. An oral or written communication with a Federal banking agency...

  4. 49 CFR 382.207 - Pre-duty use.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Pre-duty use. 382.207 Section 382.207 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY... ALCOHOL USE AND TESTING Prohibitions § 382.207 Pre-duty use. No driver shall perform...

  5. 49 CFR 195.207 - Transportation of pipe.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Transportation of pipe. 195.207 Section 195.207... PIPELINE Construction § 195.207 Transportation of pipe. (a) Railroad. In a pipeline operated at a hoop stress of 20 percent or more of SMYS, an operator may not use pipe having an outer diameter to...

  6. 8 CFR 207.7 - Derivatives of refugees.

    Science.gov (United States)

    2010-01-01

    ... unmarried, minor child as set forth in 8 CFR part 204 must be submitted with the request for accompanying or... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Derivatives of refugees. 207.7 Section 207... REFUGEES § 207.7 Derivatives of refugees. (a) Eligibility. A spouse, as defined in section 101(a)(35)...

  7. 19 CFR 207.27 - Short life cycle products.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Short life cycle products. 207.27 Section 207.27... SUBSIDIZED EXPORTS TO THE UNITED STATES Final Determinations, Short Life Cycle Products § 207.27 Short life... short life cycle merchandise which has been the subject of two or more affirmative...

  8. 28 CFR 2.207 - Supervision reports to Commission.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Supervision reports to Commission. 2.207 Section 2.207 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT....207 Supervision reports to Commission. A regular supervision report shall be submitted to...

  9. 31 CFR 0.207 - Cooperation with official inquiries.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Cooperation with official inquiries. 0.207 Section 0.207 Money and Finance: Treasury Office of the Secretary of the Treasury DEPARTMENT OF THE TREASURY EMPLOYEE RULES OF CONDUCT Rules of Conduct § 0.207 Cooperation with...

  10. 27 CFR 26.207 - Destruction of marks and brands.

    Science.gov (United States)

    2010-04-01

    ... brands. 26.207 Section 26.207 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Products Coming Into the United States From the Virgin Islands § 26.207 Destruction of marks and brands. The marks, brands, and serial numbers required by this part to be placed on barrels, casks, or...

  11. 47 CFR 90.207 - Types of emissions.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Types of emissions. 90.207 Section 90.207... MOBILE RADIO SERVICES General Technical Standards § 90.207 Types of emissions. Unless specified elsewhere in this part, stations will be authorized emissions as provided for in paragraphs (b) through (n)...

  12. 10 CFR 207.4 - Confidentiality of energy information.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Confidentiality of energy information. 207.4 Section 207.4 Energy DEPARTMENT OF ENERGY OIL COLLECTION OF INFORMATION Collection of Information Under the Energy Supply and Environmental Coordination Act of 1974 § 207.4 Confidentiality of energy information....

  13. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  14. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  15. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  16. Evidence for Bismuth-207 in Global Fallout

    DEFF Research Database (Denmark)

    Aarkrog, Asker; Dahlgaard, Henning; Holm, Elis;

    1984-01-01

    Samples of lichen, moss, soil and air collected since 1961 in Greenland, Svalbard, Iceland, the Faroe Islands, Sweden and Denmark have been remeasured for γ-emitting radionuclides by Ge(Li) spectroscopy. The samples have shown the presence of 207Bi (physical half-life 38 years), a nuclide which h...... particular the 55Mt detonation of 30 October 1961 at Novaya Zemlya may have produced this activation product....

  17. 标致207上市

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    继标致206型轿车投入批量生产之后,标致汽车公司又于2006年5月推出较之大一号的207型轿车。该车属于B级轿车范畴,主要竞争车型是火众波罗(Polo)、欧宝科尔莎(Opel Corsa)等。

  18. Resonance capture cross section of 207Pb

    CERN Document Server

    Domingo-Pardo, C; Aerts, G; Alvarez-Pol, H; Alvarez-Velarde, F; Andrzejewski, J; Andriamonje, Samuel A; Assimakopoulos, P A; Audouin, L; Badurek, G; Baumann, P; Becvar, F; Berthoumieux, E; Bisterzo, S; Calviño, F; Cano-Ott, D; Capote, R; Carrapico, C; Chepel, V; Cennini, P; Chiaveri, Enrico; Colonna, N; Cortés, G; Couture, A; Cox, J; Dahlfors, M; David, S; Dillman, I; Dolfini, R; Dridi, W; Durán, I; Eleftheriadis, C; Embid-Segura, M; Ferrant, L; Ferrari, A; Ferreira-Marques, R; Fitzpatrick, L; Frais-Kölbl, H; Fujii, K; Furman, W; Gallino, R; Gonçalves, I; González-Romero, E M; Goverdovski, A; Gramegna, F; Griesmayer, E; Guerrero, C; Gunsing, F; Haas, B; Haight, R; Heil, M; Herrera-Martínez, A; Igashira, M; Isaev, S; Jericha, E; Kadi, Y; Käppeler, F K; Karamanis, D; Karadimos, D; Kerveno, M; Ketlerov, V; Köhler, P; Konovalov, V; Kossionides, E; Krticka, M; Lamboudis, C; Leeb, H; Lindote, A; Lopes, I; Lozano, M; Lukic, S; Marganiec, J; Marrone, S; Mastinu, P; Mengoni, A; Milazzo, P M; Moreau, C; Mosconi, M; Neves, F; Oberhummer, Heinz; Oshima, M; O'Brien, S; Pancin, J; Papachristodoulou, C; Papadopoulos, C; Paradela, C; Patronis, N; Pavlik, A; Pavlopoulos, P; Perrot, L; Plag, R; Plompen, A; Plukis, A; Poch, A; Pretel, C; Quesada, J; Rauscher, T; Reifarth, R; Rosetti, M; Rubbia, Carlo; Rudolf, G; Rullhusen, P; Salgado, J; Sarchiapone, L; Savvidis, I; Stéphan, C; Tagliente, G; Taín, J L; Tassan-Got, L; Tavora, L; Terlizzi, R; Vannini, G; Vaz, P; Ventura, A; Villamarín, D; Vincente6, M C; Vlachoudis, V; Vlastou, R; Voss, F; Walter, S; Wendler, H; Wiescher, M; Wisshak, K

    2006-01-01

    The radiative neutron capture cross section of 207Pb has been measured at the CERN neutron time of flight installation n_TOF using the pulse height weighting technique in the resolved energy region. The measurement has been performed with an optimized setup of two C6D6 scintillation detectors, which allowed us to reduce scattered neutron backgrounds down to a negligible level. Resonance parameters and radiative kernels have been determined for 16 resonances by means of an R-matrix analysis in the neutron energy range from 3 keV to 320 keV. Good agreement with previous measurements was found at low neutron energies, whereas substantial discrepancies appear beyond 45 keV. With the present results, we obtain an s-process contribution of 77(8)% to the solar abundance of 207Pb. This corresponds to an r-process component of 23(8)%, which is important for deriving the U/Th ages of metal poor halo stars.

  19. 15 CFR 2011.207 - Suspension of the certificate system.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Suspension of the certificate system. 2011.207 Section 2011.207 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE ALLOCATION OF TARIFF-RATE QUOTA ON IMPORTED...

  20. Dicty_cDB: CHC207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHC207 (Link to dictyBase) - - - Contig-U16373-1 CHC207P (Link to Original ... VLIRVGTIHTFITFGAGCRIGKNLILVSKHVVHHSTFPQDKIIFNVGIXIPS KW VTAKLI--- ---XKDNEASGSSNNNXDXNLNKNHIXNSSEFTSPSFDYH ... IDXSXCQELXXXVXTVXPSXEKGTVSFSDDXRLE CNSXPEPGYXESSLIFSKW *ctiywfgxvtiyx*xx*tiivyqlx Translated Amino Acid se ... VLIRVGTIHTFITFGAGCRIGKNLILVSKHVVHHSTFPQDKIIFNVGIXIPS KW VTAKLI--- ---XKDNEASGSSNNNXDXNLNKNHIXNSSEFTSPSFDYH ... IDXSXCQELXXXVXTVXPSXEKGTVSFSDDXRLE CNSXPEPGYXESSLIFSKW *ctiywfgxvtiyx*xx*tiivyqlx Frame B: lmqk*iiiskkki*k ...

  1. Dicty_cDB: SFD207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SF (Link to library) SFD207 (Link to dictyBase) - - - Contig-U16373-1 SFD207P (Link to Original ... i*mmi*l kmklltgqx*lexxqxihxlhxxlxxxxxkt*--- ---xr**skw ***q***xxfk*kpycx***iyisii*lssfr*irkgkrxtrl*nhl*x* ...

  2. 50 CFR 226.207 - Critical habitat for leatherback turtle.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Critical habitat for leatherback turtle. 226.207 Section 226.207 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND... Critical habitat for leatherback turtle. Leatherback Sea Turtle (dermochelys coriacea) The waters...

  3. 27 CFR 555.207 - Construction of type 1 magazines.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Construction of type 1 magazines. 555.207 Section 555.207 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO... prevent sawing or lever action on the locks, hasps, and staples. These requirements do not apply...

  4. 8 CFR 207.6 - Control over approved refugee numbers.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Control over approved refugee numbers. 207... ADMISSION OF REFUGEES § 207.6 Control over approved refugee numbers. Current numerical accounting of approved refugees is maintained for each special group designated by the President. As refugee status...

  5. 8 CFR 207.9 - Termination of refugee status.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Termination of refugee status. 207.9... REFUGEES § 207.9 Termination of refugee status. The refugee status of any alien (and of the spouse or child... district director in whose district the alien is found if the alien was not a refugee within the meaning...

  6. 14 CFR 145.207 - Repair station manual.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Repair station manual. 145.207 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.207 Repair station manual. (a) A certificated repair station must prepare and follow a repair station manual acceptable to...

  7. 15 CFR 280.207 - Answer and demand for hearing.

    Science.gov (United States)

    2010-01-01

    ... the answer. Any demand by the Department for a hearing must be filed with the administrative law judge... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Answer and demand for hearing. 280.207... QUALITY Enforcement § 280.207 Answer and demand for hearing. (a) When to answer. The respondent...

  8. 14 CFR 91.207 - Emergency locator transmitters.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Emergency locator transmitters. 91.207 Section 91.207 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... governed by the supplemental air carrier and commercial operator rules of parts 121 and 125; (ii)...

  9. 19 CFR 207.63 - Circulation of draft questionnaires.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review....

  10. 37 CFR 2.207 - Methods of payment.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Methods of payment. 2.207... COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Fees and Payment of Money in Trademark Cases § 2.207 Methods of payment. (a) All payments of money required in trademark cases, including fees for the...

  11. 23 CFR 650.207 - Plans, specifications and estimates.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Plans, specifications and estimates. 650.207 Section 650... § 650.207 Plans, specifications and estimates. (a) Emphasis shall be placed on erosion control in the preparation of plans, specifications and estimates. (b) All reasonable steps shall be taken to insure...

  12. 42 CFR 50.207 - Sterilization by hysterectomy.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Sterilization by hysterectomy. 50.207 Section 50... GENERAL APPLICABILITY Sterilization of Persons in Federally Assisted Family Planning Projects § 50.207 Sterilization by hysterectomy. (a) Programs or projects to which this subpart applies shall not perform...

  13. 10 CFR 611.207 - Small automobile and component manufacturers.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Small automobile and component manufacturers. 611.207... VEHICLES MANUFACTURER ASSISTANCE PROGRAM Facility/Funding Awards § 611.207 Small automobile and component... individuals; and (2) Manufactures automobiles or components of automobiles. (b) Set Aside—Of the amount...

  14. 33 CFR 135.207 - Insurance as evidence.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Insurance as evidence. 135.207...) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OFFSHORE OIL POLLUTION COMPENSATION FUND Financial Responsibility for Offshore Facilities § 135.207 Insurance as evidence. (a) Insurance filed...

  15. 42 CFR 408.207 - Billing and payment procedures.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Billing and payment procedures. 408.207 Section 408... Surcharge Agreements § 408.207 Billing and payment procedures. (a) Adding and removing enrollees. The State... full. (d) Disagreement over billing amounts or interest. If the State or local government...

  16. 19 CFR 207.14 - Negative petition determination.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Negative petition determination. 207.14 Section... SUBSIDIZED EXPORTS TO THE UNITED STATES Preliminary Determinations § 207.14 Negative petition determination... section 732(d) of the Act that the administering authority has made a negative petition...

  17. Stability and in vivo behavior of Rh[16aneS4-diol]211At complex: A potential precursor for astatine radiopharmaceuticals

    International Nuclear Information System (INIS)

    Introduction: The heavy halogen 211At is of great interest for targeted radiotherapy because it decays by the emission of short-range, high-energy α-particles. However, many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking other 211At labeling strategies. One relatively unexplored approach is to utilize prosthetic groups based on astatinated rhodium (III) complex stabilized with a tetrathioether macrocyclic ligand – Rh[16aneS4-diol]211At. The purpose of the current study was to evaluate the in vitro and in vivo stability of this complex in comparison to its iodine analog – Rh[16aneS4-diol]131I. Methods: Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I complexes were synthesized and purified by HPLC. The stability of both complexes was evaluated in vitro by incubation in phosphate-buffered saline (PBS) and human serum at different temperatures. The in vivo behavior of the two radiohalogenated complexes was assessed by a paired-label biodistribution study in normal Balb/c mice. Results: Both complexes were synthesized in high yield and purity. Almost no degradation was observed for Rh[16aneS4-diol]131I in PBS over a 72 h incubation. The astatinated analog exhibited good stability in PBS over 14 h. A slow decline in the percentage of intact complex was observed for both tracers in human serum. In the biodistribution study, retention of 211At in most tissues was higher than that of 131I at all time points, especially in spleen and lungs. Renal clearance of Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I predominated, with 84.1 ± 2.3% and 94.6 ± 0.9% of injected dose excreted via the urine at 4 h. Conclusions: The Rh[16aneS4-diol]211At complex might be useful for constructing prosthetic groups for the astatination of biomolecules and further studies are planned to evaluate this possibility

  18. Search for the l-forbidden beta decay /sup 207/Tl→/sup 207/Pb(570 keV)

    International Nuclear Information System (INIS)

    We have searched for the l-forbidden beta decay of /sup 207/Tl to the first excited state of /sup 207/Pb by looking for 570-keV γ rays following the decay of /sup 207/Tl. We find a branching ratio of (2.4 +- 5.6) x 10/sup -7/ per /sup 207/Tl decay. This limit could provide a test for calculations of core polarization, meson exchange, and Δ excitation effects. We also find a branch of (0.54 +- 0.05)% for the l-forbidden M1 transition /sup 207/Pb(898,(3/2-→570,(5/2-) and measure the intensities of γ rays emitted following the decay of /sup 211/Pb

  19. Experiments of analog states on Lead 206 and 207

    International Nuclear Information System (INIS)

    This research thesis aims at verifying hypotheses according to which the spread of analog states decreases as much as nuclei are far from a double magic nucleus, under some conditions. Therefore, analog states of lead 207 and 208 have been studied by proton scattering on targets in lead 206 and 207. Some theoretical aspects of analog states of isobaric spin are presented. An experimental method of determination of excitation functions is described. Results obtained for analog states in bismuth 207-208 are discussed. Results obtained on four steady lead isotopes in different laboratories are compared

  20. 14 CFR 121.207 - Provisionally certificated airplanes: Operating limitations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Provisionally certificated airplanes... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.207 Provisionally certificated airplanes: Operating limitations....

  1. Dicty_cDB: CHQ207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHQ207 (Link to dictyBase) - - - Contig-U12664-1 | Contig-U16288-1 CHQ207P ... nlk*ikygsiscisiit*n*tt*sf ssl*ig**fn*kftsfticsiifn*mlc --- ---kcic*ngtfrskiiki*mfnpnrctpir*tttmlc chslhscqw ... chistosoma mansoni lung schistosomulum EST, clone SmlC 45g09.q1k. 36 0.43 3 AC115598 |AC115598.2 Dictyoste ...

  2. Radiotherapy combined with Tegafur (FT-207s) for brain tumors

    International Nuclear Information System (INIS)

    5-Fluorouracil (5-FU) has anti-tumor effects as an anti-metabolite, but it cannot pass the Blood-Brain-Barrier (BBB). FT-207 a masked-compound of 5-FU, is easily lipid soluble and is able to pass the BBB. Twenty eight patients of primary brain tumor and 8 patients of metastatic brain tumor were treated with irradiation combined with 750 mg of FT-207 suppository. Twenty four patients of primary brain tumor were treated only with irradiation as control. The mean survival time was 20.4 +- 11.8 months for the combined therapy group and 17.6 +- 8.6 months for the control. The concentration of FT-207 and 5-FU in serum and in cerebrospinal fluid (CSF) was investigated after administration of 750 mg of FT-207 suppository per annum. The maximum concentration of FT-207 and of 5-FU in serum was 20.4 +- 11.8 mcg/ml and 0.06 +- 0.02 mcg/ml, respectively. There were observed several side effects, such as anorexia, nausea, exanthema and etc. These side effects were not so great as to interrupt the therapy at the dose level of 750 mg of FT-207. However, at the dose of 1500 mg, one case showed disturbance of consciousness, to which attention should be called. (author)

  3. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  4. Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter

    International Nuclear Information System (INIS)

    The sodium/iodide symporter (NIS) has been recognized as an attractive target for radioiodine-mediated cancer gene therapy. In this study we investigated the role of human NIS for cellular uptake of the high LET α-emitter astatine-211 (211At) in comparison with radioiodine as a potential radionuclide for future applications. A mammalian NIS expression vector was constructed and used to generate six stable NIS-expressing cancer cell lines (three derived from thyroid carcinoma, two from colon carcinoma, one from glioblastoma). Compared with the respective control cell lines, steady state radionuclide uptake of NIS-expressing cell lines increased up to 350-fold for iodine-123 (123I), 340-fold for technetium-99m pertechnetate (99mTcO4-) and 60-fold for 211At. Cellular 211At accumulation was found to be dependent on extracellular Na+ ions and displayed a similar sensitivity towards sodium perchlorate inhibition as radioiodide and 99mTcO4- uptake. Heterologous competition with unlabelled NaI decreased NIS-mediated 211At uptake to levels of NIS-negative control cells. Following uptake both radioiodide and 211At were rapidly (apparent t1/2 3-15 min) released by the cells as determined by wash-out experiments. Data of scintigraphic tumour imaging in a xenograft nude mice model of transplanted NIS-modified thyroid cells indicated that radionuclide uptake in NIS-expressing tumours was up to 70 times (123I), 25 times (99mTcO4-) and 10 times (211At) higher than in control tumours or normal tissues except stomach (3-5 times) and thyroid gland (5-10 times). Thirty-four percent and 14% of the administered activity of 123I and 211At, respectively, was found in NIS tumours by region of interest analysis (n=2). Compared with cell culture experiments, the effective half-life in vivo was greatly prolonged (6.5 h for 123I, 5.2 h for 211At) and preliminary dosimetric calculations indicate high tumour absorbed doses (3.5 Gy/MBqtumour for 131I and 50.3 Gy/MBqtumour for 211At). In

  5. Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter

    Energy Technology Data Exchange (ETDEWEB)

    Petrich, T.; Helmeke, H.-J.; Meyer, G.J.; Knapp, W.H.; Poetter, E. [Department of Nuclear Medicine, Medizinische Hochschule Hannover (Germany)

    2002-07-01

    The sodium/iodide symporter (NIS) has been recognized as an attractive target for radioiodine-mediated cancer gene therapy. In this study we investigated the role of human NIS for cellular uptake of the high LET {alpha}-emitter astatine-211 ({sup 211}At) in comparison with radioiodine as a potential radionuclide for future applications. A mammalian NIS expression vector was constructed and used to generate six stable NIS-expressing cancer cell lines (three derived from thyroid carcinoma, two from colon carcinoma, one from glioblastoma). Compared with the respective control cell lines, steady state radionuclide uptake of NIS-expressing cell lines increased up to 350-fold for iodine-123 ({sup 123}I), 340-fold for technetium-99m pertechnetate ({sup 99m}TcO{sub 4}{sup -}) and 60-fold for {sup 211}At. Cellular {sup 211}At accumulation was found to be dependent on extracellular Na{sup +} ions and displayed a similar sensitivity towards sodium perchlorate inhibition as radioiodide and {sup 99m}TcO{sub 4}{sup -} uptake. Heterologous competition with unlabelled NaI decreased NIS-mediated {sup 211}At uptake to levels of NIS-negative control cells. Following uptake both radioiodide and {sup 211}At were rapidly (apparent t{sub 1/2} 3-15 min) released by the cells as determined by wash-out experiments. Data of scintigraphic tumour imaging in a xenograft nude mice model of transplanted NIS-modified thyroid cells indicated that radionuclide uptake in NIS-expressing tumours was up to 70 times ({sup 123}I), 25 times ({sup 99m}TcO{sub 4}{sup -}) and 10 times ({sup 211}At) higher than in control tumours or normal tissues except stomach (3-5 times) and thyroid gland (5-10 times). Thirty-four percent and 14% of the administered activity of {sup 123}I and {sup 211}At, respectively, was found in NIS tumours by region of interest analysis (n=2). Compared with cell culture experiments, the effective half-life in vivo was greatly prolonged (6.5 h for {sup 123}I, 5.2 h for {sup 211}At) and

  6. 33 CFR 207.750 - Puget Sound Area, Wash.

    Science.gov (United States)

    2010-07-01

    ... Transportation (U.S. Coast Guard) regulations (CFR title 46, parts 30 thru 40, parts 146 thru 154, and 49 CFR... operate. Editorial Note: For Federal Register citations affecting § 207.750, see the List of CFR Sections... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Puget Sound Area, Wash....

  7. 23 CFR 633.207 - Construction labor and materials.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Construction labor and materials. 633.207 Section 633... labor and materials. (a) Construction and materials shall be in accordance with the State highway... Provisions, Appalachian Development Highway System and Local Access Roads Construction Contracts,” Form...

  8. 24 CFR 207.256b - Modification of mortgage terms.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Modification of mortgage terms. 207... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES MULTIFAMILY HOUSING MORTGAGE INSURANCE Contract Rights and Obligations Rights and Duties...

  9. 42 CFR 447.207 - Retention of payments.

    Science.gov (United States)

    2010-10-01

    ... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS PAYMENTS FOR SERVICES Payment Methods: General Provisions § 447.207 Retention of payments. (a) Payment methodologies must permit the provider to receive and retain the full amount of the total computable payment for services furnished under the approved State plan (or...

  10. 48 CFR 17.207 - Exercise of options.

    Science.gov (United States)

    2010-10-01

    ... potential costs of disrupting operations; and (2) May consider the effect on small business. (f) Before... METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.207 Exercise of options. (a) When... renegotiation of the price for work in a fixed-price type contract; (3) In the case of a cost-type contract,...

  11. 31 CFR 538.207 - Prohibited performance of contracts.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Prohibited performance of contracts... Prohibitions § 538.207 Prohibited performance of contracts. Except as otherwise authorized, the performance by any United States person of any contract, including a financing contract, in support of an...

  12. 5 CFR 551.207 - Professional exemption criteria.

    Science.gov (United States)

    2010-01-01

    ... ADMINISTRATION UNDER THE FAIR LABOR STANDARDS ACT Exemptions and Exclusions § 551.207 Professional exemption criteria. To qualify for the professional exemption, an employee's primary duty must be the performance of... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Professional exemption criteria....

  13. 19 CFR 207.21 - Final phase notice of scheduling.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Final phase notice of scheduling. 207.21 Section... notice of scheduling. (a) Notice from the administering authority of an affirmative preliminary... the Federal Register a Final Phase Notice of Scheduling. (c) If the administering...

  14. 48 CFR 47.207-7 - Liability and insurance.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Liability and insurance... CONTRACT MANAGEMENT TRANSPORTATION Contracts for Transportation or for Transportation-Related Services 47.207-7 Liability and insurance. (a) The contracting officer shall specify— (1) The...

  15. 5 CFR 847.207 - Effective dates of elections.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Effective dates of elections. 847.207... REGULATIONS (CONTINUED) ELECTIONS OF RETIREMENT COVERAGE BY CURRENT AND FORMER EMPLOYEES OF NONAPPROPRIATED FUND INSTRUMENTALITIES Elections To Continue Retirement Coverage After a Qualifying Move §...

  16. Oscillator strengths for a Li I 207-A laser.

    Science.gov (United States)

    Nussbaumer, H

    1980-06-01

    Atomic data crucial for a proposed 207-A lithium laser have been calculated in a multiconfiguration approximation. The values obtained for the intercombination oscillator strengths ls2s2p 4 P(o)-1s2p2 2P are approximately a factor of 15 smaller than those assumed in the proposal of Harris [Opt. Lett. 5,1 (1980)]. PMID:19693180

  17. 45 CFR 170.207 - Vocabulary standards for representing electronic health information.

    Science.gov (United States)

    2010-10-01

    ... health information. 170.207 Section 170.207 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Standards and...

  18. 41 CFR 101-27.207-3 - Marking material to show extended shelf life.

    Science.gov (United States)

    2010-07-01

    ... extended shelf life. 101-27.207-3 Section 101-27.207-3 Public Contracts and Property Management Federal...-INVENTORY MANAGEMENT 27.2-Management of Shelf-Life Materials § 101-27.207-3 Marking material to show extended shelf life. When the shelf-life period of Type II material (except for critical end-use items...

  19. 33 CFR 207.10 - Charles River, Mass.; dam of Charles River Basin Commission.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Charles River, Mass.; dam of Charles River Basin Commission. 207.10 Section 207.10 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.10 Charles River, Mass.; dam...

  20. 5 CFR 880.207 - Adjustment of accounts after finding of death.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Adjustment of accounts after finding of death. 880.207 Section 880.207 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL... Procedures § 880.207 Adjustment of accounts after finding of death. After a missing annuitant is...

  1. 19 CFR 207.7 - Limited disclosure of certain business proprietary information under administrative protective...

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Limited disclosure of certain business proprietary information under administrative protective order. 207.7 Section 207.7 Customs Duties UNITED STATES... General Provisions § 207.7 Limited disclosure of certain business proprietary information...

  2. 33 CFR 207.580 - Buffalo Harbor, N.Y.; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Buffalo Harbor, N.Y.; use, administration, and navigation. 207.580 Section 207.580 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.580 Buffalo Harbor, N.Y.;...

  3. 46 CFR 14.207 - Content and form of shipping articles.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Content and form of shipping articles. 14.207 Section 14.207 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN SHIPMENT AND DISCHARGE OF MERCHANT MARINERS Shipment of Merchant Mariners § 14.207 Content and form of...

  4. 49 CFR 238.207 - Link between coupling mechanism and car body.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Link between coupling mechanism and car body. 238.207 Section 238.207 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL... Requirements for Tier I Passenger Equipment § 238.207 Link between coupling mechanism and car body....

  5. 49 CFR 40.207 - What is the effect of a cancelled drug test?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What is the effect of a cancelled drug test? 40.207 Section 40.207 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Problems in Drug Tests § 40.207 What is the effect...

  6. 10 CFR 207.3 - Method of collecting energy information under ESECA.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Method of collecting energy information under ESECA. 207.3 Section 207.3 Energy DEPARTMENT OF ENERGY OIL COLLECTION OF INFORMATION Collection of Information Under the Energy Supply and Environmental Coordination Act of 1974 § 207.3 Method of collecting...

  7. 48 CFR 47.207-9 - Annotation and distribution of shipping and billing documents.

    Science.gov (United States)

    2010-10-01

    ... billing documents. See 41 CFR part 102-118, Transportation Payment and Audit. (b) In instances of mass... distribution of shipping and billing documents. 47.207-9 Section 47.207-9 Federal Acquisition Regulations... for Transportation-Related Services 47.207-9 Annotation and distribution of shipping and...

  8. 27 CFR 44.207a - To a foreign-trade zone.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false To a foreign-trade zone. 44.207a Section 44.207a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... of Shipment § 44.207a To a foreign-trade zone. Where tobacco products, and cigarette papers and...

  9. Dicty_cDB: SLG207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 9696 ) Dictyostelium discoideum slug cDNA, clone SLG207. 359 e-165 3 ( AU052383 )... Dictyostelium discoideum slug cDNA, clone SLD229. 359 e-165 3 ( AU053303 ) Dictyostelium discoideum slug cD...NA, clone SLI350. 359 e-165 3 ( AU053244 ) Dictyostelium discoideum slug cDNA, clone SLI220. 359 e-165 3 ( A...U033975 ) Dictyostelium discoideum slug cDNA, clone SLB680. 359 e-165 3 ( AU03471...4 ) Dictyostelium discoideum slug cDNA, clone SLE226. 359 e-165 3 ( AU039609 ) Dictyostelium discoideum slug

  10. Durable donor engraftment after radioimmunotherapy using α-emitter astatine-211-labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation.

    Science.gov (United States)

    Chen, Yun; Kornblit, Brian; Hamlin, Donald K; Sale, George E; Santos, Erlinda B; Wilbur, D Scott; Storer, Barry E; Storb, Rainer; Sandmaier, Brenda M

    2012-02-01

    To reduce toxicity associated with external γ-beam radiation, we investigated radioimmunotherapy with an anti-CD45 mAb labeled with the α-emitter, astatine-211 ((211)At), as a conditioning regimen in dog leukocyte antigen-identical hematopoietic cell transplantation (HCT). Dose-finding studies in 6 dogs treated with 100 to 618 μCi/kg (211)At-labeled anti-CD45 mAb (0.5 mg/kg) without HCT rescue demonstrated dose-dependent myelosuppression with subsequent autologous recovery, and transient liver toxicity in dogs treated with (211)At doses less than or equal to 405 μCi/kg. Higher doses of (211)At induced clinical liver failure. Subsequently, 8 dogs were conditioned with 155 to 625 μCi/kg (211)At-labeled anti-CD45 mAb (0.5 mg/kg) before HCT with dog leukocyte antigen-identical bone marrow followed by a short course of cyclosporine and mycophenolate mofetil immunosuppression. Neutropenia (1-146 cells/μL), lymphopenia (0-270 cells/μL), and thrombocytopenia (1500-6560 platelets/μL) with prompt recovery was observed. Seven dogs had long-term donor mononuclear cell chimerism (19%-58%), whereas 1 dog treated with the lowest (211)At dose (155 μCi/kg) had low donor mononuclear cell chimerism (5%). At the end of follow-up (18-53 weeks), only transient liver toxicity and no renal toxicity had been observed. In conclusion, conditioning with (211)At-labeled anti-CD45 mAb is safe and efficacious and provides a platform for future clinical trials of nonmyeloablative transplantation with radioimmunotherapy-based conditioning. PMID:22134165

  11. 19 CFR 207.62 - Rulings on adequacy and nature of Commission review.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Rulings on adequacy and nature of Commission review. 207.62 Section 207.62 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE... adequacy and nature of Commission review. (a) Basis for rulings on adequacy. The Commission will assess...

  12. Alpha-Decay of $^{211}Po$ on the 1633 keV $^{207}Pb$ level

    CERN Document Server

    Chumin, V G; Malikov, Sh R; Norseev, Yu V; Samatov, Z K; Fominykh, V I; Cherevatenko, A P; Yurkova, L V

    2000-01-01

    In investigations of gamma-spectrum of ^{211}At and daughter ^{211}Po and ^{207}Bi isotopes a new branch of the alpha-decay on the ^{207}Pb 1633 keV level is discovered. Its intensity is 8.1 cdot 10^{-4} %.

  13. 19 CFR 207.94 - Protection of privileged information during panel and committee proceedings.

    Science.gov (United States)

    2010-04-01

    ... the category of individuals eligible to receive proprietary information pursuant to 19 CFR 207.93(b... 19 Customs Duties 3 2010-04-01 2010-04-01 false Protection of privileged information during panel... Regulations for the North American Free Trade Agreement § 207.94 Protection of privileged information...

  14. 33 CFR 207.185 - Taylors Bayou, Tex., Beaumont Navigation District Lock; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Taylors Bayou, Tex., Beaumont Navigation District Lock; use, administration, and navigation. 207.185 Section 207.185 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION...

  15. 50 CFR 648.207 - Herring Research Set-Aside (RSA).

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Herring Research Set-Aside (RSA). 648.207... Measures for the Atlantic Herring Fishery § 648.207 Herring Research Set-Aside (RSA). (a) NMFS shall... authorized to utilize RSA, based on the selection criteria described in the RFP. (d) NMFS shall consider...

  16. 41 CFR 101-42.207 - Transfer of hazardous materials and certain categories of property.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Transfer of hazardous materials and certain categories of property. 101-42.207 Section 101-42.207 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS UTILIZATION AND DISPOSAL 42-UTILIZATION...

  17. 5 CFR 352.207 - Exercise or termination of reemployment rights.

    Science.gov (United States)

    2010-01-01

    ... rights. 352.207 Section 352.207 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE... reemployment by the reemploying agency or by the Merit Systems Protection Board on appeal. ... separation; (3) At least 30 calendar days in advance of the person's scheduled entry into active...

  18. 33 CFR 207.187 - Gulf Intracoastal Waterway, Tex.; special floodgate, lock and navigation regulations.

    Science.gov (United States)

    2010-07-01

    ....; special floodgate, lock and navigation regulations. 207.187 Section 207.187 Navigation and Navigable... Gulf Intracoastal Waterway, Tex.; special floodgate, lock and navigation regulations. (a) Application... Colorado River Locks at Mile 400.8 and Mile 441.5, respectively, west of Harvey Lock, La., on the...

  19. 29 CFR 780.207 - Operations with respect to wild plants.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Operations with respect to wild plants. 780.207 Section 780.207 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR... respect to wild plants. Nurseries frequently obtain plants growing wild in the woods or fields which...

  20. 49 CFR 240.207 - Procedures for making the determination on vision and hearing acuity.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Procedures for making the determination on vision and hearing acuity. 240.207 Section 240.207 Transportation Other Regulations Relating to... making the determination on vision and hearing acuity. (a) Each railroad, prior to initially...

  1. 49 CFR 375.207 - What items must be in my advertisements?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false What items must be in my advertisements? 375.207... Services to My Customers General Responsibilities § 375.207 What items must be in my advertisements? (a) You and your agents must publish and use only truthful, straightforward, and honest advertisements....

  2. 40 CFR 600.207-86 - Calculation of fuel economy values for a model type.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Calculation of fuel economy values for a model type. 600.207-86 Section 600.207-86 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES...

  3. 33 CFR 207.270 - Tallahatchie River, Miss., between Batesville and the mouth; logging.

    Science.gov (United States)

    2010-07-01

    ...., between Batesville and the mouth; logging. 207.270 Section 207.270 Navigation and Navigable Waters CORPS... Tallahatchie River, Miss., between Batesville and the mouth; logging. (a) The floating of “sack”, rafts, or of... River, Miss., between Batesville, Panola County, Miss., and the mouth....

  4. NMR absolute shielding scale and nuclear magnetic dipole moment of (207)Pb.

    Science.gov (United States)

    Adrjan, Bożena; Makulski, Włodzimierz; Jackowski, Karol; Demissie, Taye B; Ruud, Kenneth; Antušek, Andrej; Jaszuński, Michał

    2016-06-28

    An absolute shielding scale is proposed for (207)Pb nuclear magnetic resonance (NMR) spectroscopy. It is based on ab initio calculations performed on an isolated tetramethyllead Pb(CH3)4 molecule and the assignment of the experimental resonance frequency from the gas-phase NMR spectra of Pb(CH3)4, extrapolated to zero density of the buffer gas to obtain the result for an isolated molecule. The computed (207)Pb shielding constant is 10 790 ppm for the isolated molecule, leading to a shielding of 10799.7 ppm for liquid Pb(CH3)4 which is the accepted reference standard for (207)Pb NMR spectra. The new experimental and theoretical data are used to determine μ((207)Pb), the nuclear magnetic dipole moment of (207)Pb, by applying the standard relationship between NMR frequencies, shielding constants and nuclear moments of two nuclei in the same external magnetic field. Using the gas-phase (207)Pb and (reference) proton results and the theoretical value of the Pb shielding in Pb(CH3)4, we find μ((207)Pb) = 0.59064 μN. The analysis of new experimental and theoretical data obtained for the Pb(2+) ion in water solutions provides similar values of μ((207)Pb), in the range of 0.59000-0.59131 μN. PMID:27265668

  5. Core excitations across the neutron shell gap in 207Tl

    Directory of Open Access Journals (Sweden)

    E. Wilson

    2015-07-01

    Full Text Available The single closed-neutron-shell, one proton–hole nucleus 207Tl was populated in deep-inelastic collisions of a 208Pb beam with a 208Pb target. The yrast and near-yrast level scheme has been established up to high excitation energy, comprising an octupole phonon state and a large number of core excited states. Based on shell-model calculations, all observed single core excitations were established to arise from the breaking of the N=126 neutron core. While the shell-model calculations correctly predict the ordering of these states, their energies are compressed at high spins. It is concluded that this compression is an intrinsic feature of shell-model calculations using two-body matrix elements developed for the description of two-body states, and that multiple core excitations need to be considered in order to accurately calculate the energy spacings of the predominantly three-quasiparticle states.

  6. 30 CFR 204.207 - Who will approve, deny, or modify my request for accounting and auditing relief?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who will approve, deny, or modify my request for accounting and auditing relief? 204.207 Section 204.207 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and Auditing Relief § 204.207 Who...

  7. 5 CFR 875.207 - What happens if I am in nonpay status during an open season?

    Science.gov (United States)

    2010-01-01

    ... during an open season? 875.207 Section 875.207 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT....207 What happens if I am in nonpay status during an open season? (a) If you return to a pay status from nonpay status during the open season, you have 60 days from the date of your return, or until...

  8. CD207在白癜风发病机制中的作用研究%The role of CD207 in the pathogenesis of vitiligo

    Institute of Scientific and Technical Information of China (English)

    徐武生; 张江安; 于建斌; 刘冬冬; 李税琪; 郑良娟; 王绘霞

    2014-01-01

    目的:观察白癜风皮损中CD207的表达,探讨白癜风的免疫发病机制。方法采用免疫组织化学法检测12例节段型白癜风、25例寻常型白癜风和10例正常皮肤组织中CD207的表达水平,并比较其差异性。结果节段型白癜风组、寻常型白癜风组表皮内CD207表达分别为(61.2±10.9)和(64.3±12.5)个/mm,均高于正常对照组(52.4±10.3)个/mm,差异有统计学意义(P﹤0.05)。节段型白癜风组与寻常型白癜风组相比,CD207表达差异无统计学意义( P﹥0.05)。结论节段型白癜风、寻常型白癜风皮损组织中CD207的表达高于正常对照组,提示其发病机制与朗格汉斯细胞参与的细胞免疫反应有关。%Objective To observe the expression of CD207 in the lesions of vitiligo and the immune pathogenesis of vitiligo. Meth-ods The CD207 expression level was detected by immunohistochemistry in 12 patients with segmental vitiligo,25 patients with vitiligo vulgaris and 10 normal skin tissues,and the results were compared. Re-sults The expression of CD207 in segmental vitiligo group and vitiligo vulgaris group was(61. 2 ± 10. 9) and(64. 3 ± 12. 5)count/mm respectively,(52. 4 ± 10. 3)count/mm in control group. The differences were statistically significant( P﹤0. 05 ). Conclusions The expression of CD207 in the lesions of seg-mental vitiligo and vitiligo vulgaris is higher than that in the normal control group,indicating that the mechanism of vitiligo is associated with the cellular immunity response which langerhans cell was in-volved.

  9. 31 CFR 575.207 - Prohibited transactions relating to travel to Iraq or to activities within Iraq.

    Science.gov (United States)

    2010-07-01

    ... travel to Iraq or to activities within Iraq. 575.207 Section 575.207 Money and Finance: Treasury... Iraq or to activities within Iraq. Except as otherwise authorized, no U.S. person may engage in any transaction relating to travel by any U.S. citizen or permanent resident alien to Iraq, or to activities...

  10. 33 CFR 207.718 - Navigation locks and approach channels, Columbia and Snake Rivers, Oreg. and Wash.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Navigation locks and approach channels, Columbia and Snake Rivers, Oreg. and Wash. 207.718 Section 207.718 Navigation and Navigable... Navigation locks and approach channels, Columbia and Snake Rivers, Oreg. and Wash. (a) General. All...

  11. 33 CFR 207.169 - Oklawaha River, navigation lock and dam at Moss Bluff, Fla.; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Oklawaha River, navigation lock and dam at Moss Bluff, Fla.; use, administration, and navigation. 207.169 Section 207.169 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE...

  12. 24 CFR 207.252c - Premiums-mortgages insured pursuant to section 238(c) of the Act.

    Science.gov (United States)

    2010-04-01

    ... HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES MULTIFAMILY HOUSING MORTGAGE INSURANCE Contract Rights.... All of the provisions of §§ 207.252 and 207.252a governing mortgage insurance premiums shall apply...

  13. 33 CFR 207.260 - Yazoo Diversion Canal, Vicksburg, Miss., from its mouth at Kleinston Landing to Fisher Street...

    Science.gov (United States)

    2010-07-01

    ..., Miss., from its mouth at Kleinston Landing to Fisher Street; navigation. 207.260 Section 207.260... Street; navigation. (a) Signals. Vessels navigating the canal will be governed by the Pilot Rules for... Clay Street) at Vicksburg City Front. No vessel or raft shall be moored along the west bank of...

  14. 75 FR 69861 - Airworthiness Directives; Cessna Aircraft Company (Cessna) 172, 175, 177, 180, 182, 185, 206, 207...

    Science.gov (United States)

    2010-11-16

    ....johnson@faa.gov . SUPPLEMENTARY INFORMATION: Airworthiness Directive 2008-26-10, Amendment 39-15776 (73 FR... Company (Cessna) 172, 175, 177, 180, 182, 185, 206, 207, 208, 210, 303, 336, and 337 Series Airplanes... obstruction is found for certain Cessna 172, 175, 177, 180, 182, 185, 206, 207, 208, 210, 303, 336, and...

  15. Treatment of cultured glioma cells with the EGFR-TKI gefitinib (''Iressa'', ZD1839) increases the uptake of astatinated EGF despite the absence of gefitinib-mediated growth inhibition

    International Nuclear Information System (INIS)

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib (''Iressa'', ZD1839), a reversible growth inhibitor of EGFR-expressing tumour cells, has been shown to enhance the antitumour effect of ionising radiation, and also to increase the uptake of radioiodinated EGF. Thus, combination of gefitinib treatment and radionuclide targeting is an interesting option for therapy of brain tumours that are difficult to treat with conventional methods. The aim of this study was to evaluate how pre-treatment with gefitinib affects binding of astatinated EGF (211At-EGF) to cultured glioma U343 cells, which express high levels of EGFR. The growth of U343 cells in the presence of gefitinib was investigated, and it was found that gefitinib does not significantly inhibit the growth of these cells. Nevertheless, the uptake of 211At-EGF in U343 cells was markedly increased (up to 3.5 times) in cells pre-treated with gefitinib (1 μM). This indicates that a combination of gefitinib treatment and radionuclide targeting to EGFR might be a useful therapeutic modality, even for patients who do not respond to treatment with gefitinib alone. (orig.)

  16. Low-metallicity Young Clusters in the Outer Galaxy I. Sh 2-207

    CERN Document Server

    Yasui, Chikako; Tokunaga, Alan T; Saito, Masao; Izumi, Natsuko

    2015-01-01

    To study star formation in low metallicity environments ([M/H] ~ -1 ,dex), we obtained deep near-infrared (NIR) images of Sh 2-207 (S207), which is an HII region in the outer Galaxy with spectroscopically determined metallicity of [O/H] ~= -0.8 dex. We identified a young cluster in the western region of S207 with a limiting magnitude of Ks =19.0 mag (10 sigma) that corresponds to a mass detection limit of <~0.1 M_sun and enables the comparison of star-forming properties under low metallicity with those of the solar neighborhood. From the fitting of the K-band luminosity function (KLF), the age and distance of S207 cluster are estimated at 2-3Myr and ~4 kpc, respectively. The estimated age is consistent with the suggestion of small extinctions of stars in the cluster (Av ~ 3 mag) and the non-detection of molecular clouds. The reasonably good fit between observed KLF and model KLF suggests that the underlying initial mass function (IMF) of the cluster down to the detection limit is not significantly differen...

  17. 49 CFR 399.207 - Truck and truck-tractor access requirements.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Truck and truck-tractor access requirements. 399... Vehicles § 399.207 Truck and truck-tractor access requirements. (a) General rule. Any person entering or exiting the cab or accessing the rear portion of a high profile COE truck or truck-tractor shall...

  18. Study of 207Tl126 Produced in Deep-Inelastic Reactions

    Directory of Open Access Journals (Sweden)

    Wilson E.

    2014-03-01

    Full Text Available Deep-inelastic collisions of a 208Pb beam on a 208Pb target were performed using the ATLAS accelerator at Argonne National Laboratory. The Gammasphere detector array was used for the detection of prompt and delayed gamma-rays of the reaction products.207Tl is one proton away from the 208Pb doubly-magic nucleus. Its low-energy level structure is dominated by the single proton-hole states πs1/2−1, πd3/2−1 and πh11/2−1. The 11/2− state is isomeric with T1/2 = 1.33(11 s. The reaction partner of 207Tl is 209Bi, which has arelatively well established level scheme compared to 207Tl. Cross-coincidences between these two nuclei were used to confirm or establish levels above the 11/2− isomeric state in 207Tl. These states are obtained via breaking of the neutron core. Angular correlation analysis was performed on known transitions in 208Pb, proving the applicability of this method for multipolarity assignment.

  19. 40 CFR 33.207 - Can an entity reapply to EPA for MBE or WBE certification?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Can an entity reapply to EPA for MBE or... ENVIRONMENTAL PROTECTION AGENCY PROGRAMS Certification § 33.207 Can an entity reapply to EPA for MBE or WBE certification? An entity which has been denied MBE or WBE certification may reapply for certification at...

  20. 49 CFR 236.207 - Electric lock on hand-operated switch; control.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Electric lock on hand-operated switch; control..., AND APPLIANCES Automatic Block Signal Systems Standards § 236.207 Electric lock on hand-operated switch; control. Electric lock on hand-operated switch shall be controlled so that it cannot be...

  1. Fragmentation of few-quasiparticle components of highly excited states in sup(207,208)Pb

    International Nuclear Information System (INIS)

    The s-, p- and d-wave neutron strength functions are calculated for sup(207, 208)Pd. Their energy dependence is correctly described. The fine structure of the isoscalar quadrupole resonance is explained and the description for the low-lying octupole resonance and high-lying isoscalar octupole resonance in 208Pb is obtained in agreement with the experimental data

  2. 34 CFR 668.207 - Preventing evasion of the consequences of cohort default rates.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Preventing evasion of the consequences of cohort... Cohort Default Rates § 668.207 Preventing evasion of the consequences of cohort default rates. (a... institution, the same person (as defined in 34 CFR 600.31) or members of that person's family, directly...

  3. 48 CFR 1415.207-70 - Department of the Interior proposal and information handling procedures.

    Science.gov (United States)

    2010-10-01

    ... NEGOTIATION Solicitation and Receipt of Proposals and Information 1415.207-70 Department of the Interior... information and confidential commercial and financial information contained in solicited proposals. (b) Marking of solicited proposals. A solicited proposal may contain trade secrets or confidential...

  4. Core breaking and octupole low-spin states in $^{207}$ Tl

    CERN Multimedia

    We propose to study the low-spin level structure of the $^{207}$Tl nucleus populated by the $\\beta$- decay of $^{207}$Hg. While $^{207}$Tl is a single-proton hole nucleus, the majority of the observed states will have threeparticle structure thus requiring the breaking of the neutron or proton core, or a collective octupole phonon coupled to the single proton hole. Thus information will be obtained on the single particle orbitals in the vicinity of the N=126 and Z=82 magic numbers, and on the size of the shell gap. The results will be used to improve the predictive power of the shell model for more exotic nuclei as we move to lighter N=126 nuclei.The experiment will use the ISOLDE Decay station, and will take advantage of the $^{207}$Hg beam from the molten lead target. A test on the feasibility to produce $^{208}$Hg beam from the same target, with the aim to study the $\\beta$-decay into $^{208}$Tl, could be performed at the same time.

  5. Study of 207Tl126 produced in deep-inelastic reactions

    International Nuclear Information System (INIS)

    Deep-inelastic collisions of a 208Pb beam on a 208Pb target were performed using the ATLAS accelerator at Argonne National Laboratory. The Gamma-sphere detector array was used for the detection of prompt and delayed gamma-rays of the reaction products. 207Tl is one proton away from the 208Pb doubly-magic nucleus. Its low-energy level structure is dominated by the single proton-hole states πs(1/2)-1, πd(3/2)-1 and πh(11/2)-1. The (11/2)- state is isomeric with T1/2= 1.33(11) s. The reaction partner of 207Tl is 209Bi, which has a relatively well established level scheme compared to 207Tl. Cross-coincidences between these two nuclei were used to confirm or establish levels above the (11/2)- isomeric state in 207Tl. These states are obtained via the breaking of the neutron core. Angular correlation analysis was performed on known transitions in 208Pb, proving the applicability of this method for multipolarity assignment. (authors)

  6. 20 CFR 10.207 - May an employee who returns to work, then stops work again due to the effects of the injury...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false May an employee who returns to work, then stops work again due to the effects of the injury, receive COP? 10.207 Section 10.207 Employees... Eligibility for Cop § 10.207 May an employee who returns to work, then stops work again due to the effects...

  7. Michael Scotus Liber de signis et imaginibus celi im Codex Cusanus 207. Eine ikonografische Fallstudie

    Czech Academy of Sciences Publication Activity Database

    Panušková, Lenka

    Wien : Fassbaender, 2012 - (Simek, R.; Klein, M.), s. 151-160 ISBN 978-3-902575-47-0. [Johannes von Gmunden - zwischen Astronomie und Astrologie. Gmunden (AT), 17.06.2011-19.06.2011] Institutional support: RVO:68378033 Keywords : iconography * Codex Cusanus 207 Subject RIV: AL - Art, Architecture, Cultural Heritage http://hsozkult.geschichte.hu-berlin.de/index.asp?id=3784&view=pdf&pn=tagungsberichte

  8. Sterilizing activity of second-line regimens containing TMC207 in a murine model of tuberculosis.

    Directory of Open Access Journals (Sweden)

    Nicolas Veziris

    Full Text Available RATIONALE: The sterilizing activity of the regimen used to treat multidrug resistant tuberculosis (MDR TB has not been studied in a mouse model. OBJECTIVE AND METHODS: Swiss mice were intravenously inoculated with 6 log10 of Mycobacterium tuberculosis (TB strain H37Rv, treated with second-line drug combinations with or without the diarylquinoline TMC207, and then followed without treatment for 3 more months to determine relapse rates (modified Cornell model. MEASUREMENTS: Bactericidal efficacy was assessed by quantitative lung colony-forming unit (CFU counts. Sterilizing efficacy was assessed by measuring bacteriological relapse rates 3 months after the end of treatment. MAIN RESULTS: The relapse rate observed after 12 months treatment with the WHO recommended MDR TB regimen (amikacin, ethionamide, pyrazinamide and moxifloxacin was equivalent to the relapse rate observed after 6 months treatment with the recommended drug susceptible TB regimen (rifampin, isoniazid and pyrazinamide. When TMC207 was added to this MDR TB regimen, the treatment duration needed to reach the same relapse rate dropped to 6 months. A similar relapse rate was also obtained with a 6-month completely oral regimen including TMC207, moxifloxacin and pyrazinamide but excluding both amikacin and ethionamide. CONCLUSIONS: In this murine model the duration of the WHO MDR TB treatment could be reduced to 12 months instead of the recommended 18-24 months. The inclusion of TMC207 in the WHO MDR TB treatment regimen has the potential to further shorten the treatment duration and at the same time to simplify treatment by eliminating the need to include an injectable aminoglycoside.

  9. IL-17A is not expressed by CD207+ cells in Langerhans Cell Histiocytosis lesions

    OpenAIRE

    Allen, Carl E.; McClain, Kenneth L.

    2009-01-01

    Interleukin-17 (IL-17A) is a pro-inflammatory cytokine that has recently been implicated in pathogenesis of Langerhans Cell Histiocytosis (LCH), a potentially fatal disease characterized by lesions including CD207+ (langerin +) histiocytes. However, in this study we were unable to identify IL-17A gene expression in Langerhans cell lesions, and plasma levels of IL-17A did not correlate with disease activity. Therefore, this study does not support a central role for IL-17A in LCH pathogenesis.

  10. Analisis Film Horor Indonesia Produksi Tahun 2014 (Studi Kasus: Mall Klender dan Kamar 207

    Directory of Open Access Journals (Sweden)

    Dedi Sukatno Sembiring Meliala

    2016-02-01

    Full Text Available Abstrak Film horor erat kaitannya dengan tokoh antagonis yang menimbulkan ketakutan pada penonton dalam bentuk makhluk supranatural seperti hantu, roh jahat dan sebagainya. Karakteristik film dengan genre horor membuat penonton terbawa suasana dengan alur ceritanya yang menakutkan. Namun, beberapa dari film horor Indonesia menyajikan adegan-adegan yang kurang sopan bahkan tergolong asusila atau porno. Untuk itu, penelitian ini ingin melihat apakah terdapat konten pornografi pada film Mall Klender dan Kamar 207 yang merupakan film horor Indonesia terlaris di tahun 2014. Analisis dilakukan dengan melihat pandangan dan penilaian 30 responden dengan karakteristik yaitu penonton film horor Indonesia yang berusia 20-40 tahun. Berdasarkan hasil analisis, tidak didapatkan konten pornografi pada film Mall Klender dan Kamar 207. Adegan-adegan yang terindikasi sebagai konten pornografi ternyata masih dapat diterima oleh penonton sebagai adegan yang berada dalam batas kewajaran dan mendukung pembawaan suasana dan kesan dalam cerita yang disampaikan. Kata Kunci: film horror Indonesia, analisis konten, pornografi Abstract The horror film is closely related to the antagonist that causes fear for audience in the form of supernatural creatures such as ghosts, demons and so on. Characteristic of the horor film is to make the audience carried away with the scary plot. However, some of the existing Indonesian horror film presents scenes that classified as obscene or pornographic. Therefore, this study wanted to see if there are any pornographic content on the film Klender Mall and Room 207 is the best-selling Indonesian horror movie in 2014. The analysis was done by looking at the view and assessment of 30 respondents which are Indonesian horror movie goers aged 20-40 years. Based on the analysis, there is no founding of pornographic content on the film Klender Mall and Room 207. The scenes that indicated as pornographic content was still acceptable by the audience

  11. Concentrations of 207Bi and 210Pb-210Bi-210Po disequilibrium in fish

    International Nuclear Information System (INIS)

    Radioactive 207Bi, produced during nuclear testing at the Pacific Proving Grounds, concentrates in the muscle tissue and organs of goatfish and certain pelagic lagoon fish from Bikini and Enewetak Atolls. It is reasonable to expect that fish capable of accumulating 207Bi could also be efficient accumulators of other bismuth isotopes - namely 210Bi, the daughter of naturally occurring 210Pb. Therefore, 210Bi and consequently 210Po, the decay product of 210Bi, would be expected in notable excess over the precursor 210Pb in specific tissues. To test this assumption, we compared concentrations of 210Pb, 210Bi, and 210Po in muscle, liver, and bone separated from some reef species from the Marshall Islands. Concentrations of 210Bi in muscle and liver were found to exceed those of its precursor by factors of 2 to 15. The excess 210Bi in some species, however, is not from the environmental sources (either food or water) from which 207Bi is derived. The data suggest that the excess 210Bi may be translocated to muscle and liver tissue following the decay of 210Pb in bone

  12. NanoSIMS 207Pb-206Pb dating of monazite, xenotime and baddeleyite

    Science.gov (United States)

    Verdel, C.; Mahan, K.; Guan, Y.; Eiler, J.; Wernicke, B.

    2007-12-01

    A variety of geochronological problems call for in-situ dating with high spatial resolution (i.e., scales of tens of microns or less). Such techniques are particularly important for studies that focus on the relationships between intracrystalline age variations and petrologic or diagenetic processes. Precise, in-situ geochronology of particularly small grains or domains (ca. 1-5 microns) may be feasible with the Cameca NanoSIMS ion microprobe, which has a spatial resolution as good as tens of nanometers and sufficient mass resolution at high transmission to be useful for geochronologic systems involving isotopes of trace elements. We have used the Cameca NanoSIMS 50L housed in the Caltech Microanalysis Center to determine 207Pb/206Pb ages of monazite, xenotime and baddeleyite standards ranging in age from ~500 to 2000 Ma. Initial efforts focused on Pb-Pb geochronology because it is analytically straightforward: Pb is ionized almost entirely to Pb+ and instrumental mass fractionation of Pb isotopes is negligible. We compare our results to previous age determinations made on these standards using TIMS, SHRIMP and electron microprobe techniques. Our NanoSIMS 207Pb/206Pb age of 2047±35 Ma (2σ) for a baddeleyite crystal from the Phalaborwa carbonatite overlaps with the previously determined TIMS and SHRIMP dates of ca. 2060 Ma. We measured an age of 1018±20 Ma on xenotime standard x6413, slightly older than the TIMS 207Pb/206Pb date of 996.7±0.8 Ma. For the high-Th Moacyr monazite standard, variations of common-Pb corrected ages and 206Pb/204Pb ratios for 5 measurements spanning ~100 microns suggest varying amounts of interference from a mass-204 isobar (probably doubly ionized ThNdO2). The single measurement least-affected by this isobar corresponds to a common-Pb corrected 207Pb/206Pb age of 489±92 Ma, within error of the electron microprobe chemical age of ca. 505 Ma. Spatial variation of the mass-204 isobar intensity suggests that Th may be distributed

  13. A suggested search for 207Pb nuclear Schiff moment in PbTiO3 ferroelectric

    CERN Document Server

    Mukhamedjanov, T N

    2004-01-01

    We suggest two types of experiments, NMR and macroscopic magnetometry, with solid PbTiO3 to search for the nuclear Schiff moment of 207Pb. Both kinds of experiments promise substantial improvement over the presently achieved sensitivities. Statistical considerations show that the improvement of the current sensitivity can be up to 10 orders of magnitude for the magnetometry experiment. Such significant enhancement is due to the strong internal electric field of the ferroelectric, as well as due to the possibility to cool the nuclear-spin subsystem in the compound down to nanokelvin temperatures.

  14. CP-MAS 207Pb with 19F decoupling NMR spectroscopy: medium range investigation in fluoride materials.

    Science.gov (United States)

    Bureau, B; Silly, G; Buzaré, J Y

    1999-11-01

    The isotropic chemical shift of 207Pb is used to perform structural investigations of crystalline fluoride compounds (PbF2, Pb2ZnF6, PbGaF5, Pb3Ga2F12 and Pb9Ga2F24) and transition metal fluoride glasses (TMFG) of the PZG family (PbF2-ZnF2-GaF3). Using 207Pb Cross Polarisation Magic Angle Spinning (CP-MAS) NMR with 19F decoupling, it is shown that the isotropic chemical shift of 207Pb varies on a large scale (1000 ppm) and that the main changes of its value are not due to the nearest neighbour fluorines but may be related to the number of next nearest neighbour (nnn) Pb2+ ions. In this way, it is demonstrated that 207Pb chemical shift is an interesting probe to investigate medium range order in either crystalline or glassy fluoride systems. The 207Pb delta(iso) parameter has been linearly correlated to the number of nnn Pb2+ ions. PMID:10670899

  15. Immunochemotherapy for advanced bladder cancer using FT-207, adriamycin and OK-432.

    Science.gov (United States)

    Mishina, T; Watanabe, H; Fujiwara, T; Kobayashi, T; Maegawa, M; Nakao, M; Nakagawa, S

    1982-10-01

    A combination therapy consisting of daily intrarectal administration of 1,500 mg of FT-207 suppository, daily or every three day bladder instillation of 40 mg adriamycin for a total of 20 applications, and once per week intramuscular administration of 5 KE OK-432 was described. The therapy was performed in 30 cases of advanced bladder cancer. The effectiveness evaluated by Karnofsky's criteria was as follows: 8 cases of 0-0, 2 of 0-A, 1 of 0-B, 2 of 0-C, 7 of 1-A and 10 of 1-B, showing an effective rate of 57%. Local pain was observed in 20 cases (67%), pancytopenia in 1 (3%), hepatitis in 4 (13%), stomatitis in 5 (17%) and anorexia in 6 (20%). From this clinical trial, it is presumed that combination therapy administering FT-207 intrarectally, adriamycin intravesically and OK-432 intramuscularly might be used for the treatment of advanced bladder cancer provided sufficient care is taken of general side effects. PMID:6817468

  16. Measurement of the L/K electron capture ratio of the {sup 207}Bi decay to the 1633 keV level of {sup 207}Pb with a BGO scintillating bolometer

    Energy Technology Data Exchange (ETDEWEB)

    Coron, N.; Gironnet, J.; Marcillac, P. de; Martinez, M.; Redon, T.; Torres, L. [Universite Paris-Sud 11 et CNRS (UMR 8617), Institut d' Astrophysique Spatiale, Orsay (France); Cuesta, C.; Garcia, E.; Ginestra, C.; Ortigoza, Y.; Pobes, C.; Puimedon, J.; Salinas, A.; Sarsa, M.L. [Universidad de Zaragoza, Grupo de Fisica Nuclear y Astroparticulas, Zaragoza (Spain); Watrin, A. [Universidad de Zaragoza, Grupo de Fisica Nuclear y Astroparticulas, Zaragoza (Spain); Universite Louis Pasteur, Ecole nationale superieure de physique de Strasbourg (ENSPS), Illkirch (France)

    2012-06-15

    The ROSEBUD Collaboration has dedicated several underground runs to study different types of bolometers, mainly for the search of dark matter. Some of these runs, profiting from the good energy resolution of one bolometer of BGO and the ultra-low background of the underground laboratory of Canfranc (LSC), allowed the measurement of the L/K electron capture ratio of the {sup 207}Bi decay to the 1633 keV level of {sup 207}Pb. This paper constitutes the first published measurement of this magnitude. (orig.)

  17. Interactions of 160 GeV/Nucleon $^{207}$Pb Nuclei in Emulsion Chambers with Copper and Lead Targets

    CERN Multimedia

    2002-01-01

    % EMU13 \\\\ \\\\ Nuclear emulsions will be used as targets and trackers to investigate the interactions of $^{207}$Pb nuclei in emulsion, copper and lead targets; specifically (i) the pseudorapidity distributions of charged particles including analysis of particle fluctuations in pseudorapidity and azimuthal angle distributions, (ii) the transverse momentum distribution of $\\alpha$ fragments from the projectile nucleus. \\\\ \\\\Several emulsion chambers with different geometry and targets will be exposed to the $^{207}$Pb beam. Each chamber will be irradiated with the beam of low density $^{207}$Pb ions (several hundred per cm$^2$). Interactions with small impact parameter, characterized by high multiplicity and disruption of the projectile nucleus will be found with high efficiency. Measurements in the emulsion will include the number and emission angles of charged particles produced and the emission angles of $\\alpha$ fragments from the projectile nucleus.

  18. Photoelectrical properties of solid solution of (TIGaSe2)0.7(TIInS2)0.3

    International Nuclear Information System (INIS)

    Synthesis and development of new semiconductor compounds with complex of technical important properties, with a perfect crystal lattice and a high degree of purity is one of the main objectives of semiconductor Physics. In this paper it was studied some photoresistive characteristics of receivers based on (TIGaSe2)0.7(TIInS2)0.3 compounds. Bridgman method was also used, due to the layering structure. The experimental results showed that the photoresists based on (TIGaSe2)0.7(TIInS2)0.3 are photosensitive in the impurity region

  19. 40 CFR 600.207-08 - Calculation and use of vehicle-specific 5-cycle-based fuel economy values for vehicle...

    Science.gov (United States)

    2010-07-01

    ...-specific 5-cycle-based fuel economy values for vehicle configurations. 600.207-08 Section 600.207-08 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later Model...

  20. 5 CFR 792.207 - When does the child care subsidy program law become effective and how may agencies take advantage...

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false When does the child care subsidy program law become effective and how may agencies take advantage of this law? 792.207 Section 792.207... When does the child care subsidy program law become effective and how may agencies take advantage...

  1. Synthesis and X-ray structures of novel lead(1+) and indium(3+) phosphazenide complexes; detailed {sup 207}Pb-NMR spectra of the {sup 207}Pb-labelled dimeric lead(1+) species

    Energy Technology Data Exchange (ETDEWEB)

    Winkler, A.; Heinemann, F.W.; Garcia-Montalvo, V.; Moll, M.; Ellermann, J. [Erlangen-Nuernberg Univ., Erlangen (Germany). Inst. fuer Anorganische Chemie; Bauer, W. [Erlangen-Nuernberg Univ., Erlangen (Germany). Inst. fuer Organische Chemie

    1998-04-01

    The reaction of PbCl{sub 2} with LiN(PPh{sub 2}){sub 2} (1) at -78 C affords the P-P coupled phosphazene Ph{sub 2}P-N=PPh{sub 2}-PPh{sub 2}=N-PPH{sub 2} (2) as an oxidation product and, as a reduction equivalent, the novel lead(1+) complex [(Pb{sup +1}){sub 2}({mu}Ph{sub 2}P-N-PPh{sub 2}{sup -}){sub 2}](Pb-Pb) (3). The crystal structure determination of the red compound 3 shows a Pb-Pb bond length of 304.1(1) pm. The {sup 31}P- and {sup 207}Pb-NMR spectra of 3 are complicated due to the presence of a higher order spin system (AA`A``A```X for the mono-{sup 207}Pb isotopomer, AA`A``A```X` for the bis-{sup 207}Pb isotopomer). Simulations of the {sup 31}Pb and {sup 207}Pb spectra both on material with natural isotope abundance and on the {sup 207}Pb-labelled compound (3*) reveal a large Pb, Pb coupling constant of 7708 Hz, indicative of a covalent Pb-Pb bond. - Through InCl{sub 3} is diagnonally related to PbCl{sub 2}, no significant redox process is observed in the reaction between InCl{sub 3} and 1. The yellow crystal of [In{sup 3+}(Ph{sub 2}P-N-PPh{sub 2}{sup -}){sub 3}] (4) that are obtained were also investigated by X-ray analysis. These show a propeller-like configuration of the three four-membered chelate rings with indium(3+) as the centre. (orig.)

  2. 33 CFR 207.640 - Sacramento Deep Water Ship Channel Barge Lock and Approach Canals; use, administration, and...

    Science.gov (United States)

    2010-07-01

    ... mooring or anchoring of boats or other craft in the approaches to the lock, where such mooring will... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Sacramento Deep Water Ship... REGULATIONS § 207.640 Sacramento Deep Water Ship Channel Barge Lock and Approach Canals; use,...

  3. 5 CFR Appendix B to Part 2641 - Agency Components for Purposes of 18 U.S.C. 207(c)

    Science.gov (United States)

    2010-01-01

    ... following agencies is determined, for purposes of 18 U.S.C. 207(c), and 5 CFR 2641.204, to have within it... 21 offices). Office on Violence Against Women 4 (effective March 8, 2007). 4 The Office on Violence...). Administration for Children and Families (effective January 28, 1992). Agency for Healthcare Research and...

  4. 33 CFR 207.170a - Eugene J. Burrell Navigation Lock in Haines Creek near Lisbon, Fla.; use, administration, and...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Eugene J. Burrell Navigation Lock... REGULATIONS § 207.170a Eugene J. Burrell Navigation Lock in Haines Creek near Lisbon, Fla.; use, administration, and navigation. (a) The owner of or agency controlling the lock shall not be required to...

  5. 33 CFR 207.476 - The Inland Route-lock in Crooked River, Alanson, Mich.; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false The Inland Route-lock in Crooked... § 207.476 The Inland Route—lock in Crooked River, Alanson, Mich.; use, administration, and navigation. (a) General. The use, administration, and navigation of the lock shall be under the direction...

  6. 34 CFR 403.207 - What are the State's responsibilities to the National Center or Centers for Research in...

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF EDUCATION STATE VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAM What Are the Administrative Responsibilities of a State Under the State Vocational and Applied Technology Education Program? § 403.207 What are... 34 Education 3 2010-07-01 2010-07-01 false What are the State's responsibilities to the...

  7. 27 CFR 19.207 - Alternate use of distilled spirits plant and volatile fruit-flavor concentrate premises.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Alternate use of distilled... DISTILLED SPIRITS PLANTS Qualification of Distilled Spirits Plants Alternate Operations § 19.207 Alternate use of distilled spirits plant and volatile fruit-flavor concentrate premises. If a proprietor...

  8. 7 CFR 1710.207 - RUS criteria for approval of load forecasts by distribution borrowers not required to maintain an...

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false RUS criteria for approval of load forecasts by... GUARANTEES Load Forecasts § 1710.207 RUS criteria for approval of load forecasts by distribution borrowers... considered a range of relevant assumptions; and (d) The borrower provided RUS with adequate documentation...

  9. Clinical analysis of 207 cases of cerebral stroke reduced by alcohol%对207例酒精所致脑卒中患者临床资料的分析

    Institute of Scientific and Technical Information of China (English)

    张萍; 张军; 娄芳; 王传升

    2014-01-01

    Objective To study and analyze the clinical symptoms of patients with cerebral stroke reduced by alcohol . Methods A retrospective analysis of 207 cases of chronic alcohol consumption in patients with cerebral stroke which were identified as cerebral stroke by the imaging and a clinical analysis on the symptoms were made. Result A large number of long-term drinkers have blood pressure, elevated blood lipids, red blood cell, platelet abnormality and local cerebral bloodflow reduction, which easily lead to cerebral stroke. These kinds of cerebral stroke are more ischemic and rare hemorrhagic. Conclusion Long term drinking is a risk factor of cerebral stroke it and is worth to attention.%目的:分析207例酒精所致脑卒中患者的临床资料,探讨酒精中毒与脑卒中发病之间的关联性。方法:将207例因饮酒导致脑卒中的患者作为研究对象,对其临床症状进行分析。结果:在本研究中,有42例患者发生出血性脑卒中,占20.29%(42/207);有165例患者发生缺血性脑卒中,占79.71%(165/207)。在本组患者中,有93.24%(193/207)的患者有十年以上的饮酒史,有71.01%(147/207)的患者有20年以上的饮酒史,有14例患者的饮酒史为5-10年,所有患者在发病前均有不同程度的酒精中毒症状,有55.07%(114/207)的患者有经常醉酒史。在本组患者中,有30.92%(64/207)的患者在长期饮酒且发生慢性酒精中毒的基础上突然在一次醉酒后发生脑卒中(或在醉酒后24个小时内发病),其发病比由高血压诱发的脑卒中更迅速。结论:酒精中毒可影响人体内血脂、血压的水平、脑组织的血流量、红细胞及血小板的功能,进而增加其发生脑卒中的几率。避免酗酒是预防脑卒中的重要措施之一。

  10. First direct observation of bound-state beta-decay: Measurements of branching and lifetime of 207Tl81+ fragments

    International Nuclear Information System (INIS)

    The first experimental observation of bound-state beta-decay showed, that due solely to the electron stripping, a stable nuclide, e.g. 163Dy, became unstable. Also a drastic modification of the half-life of bare 187Re, from 4.12(2) x 1010 years down to 32.9(20) years, could be observed. It was mainly due to the possibility for the mother nuclide to decay into a previously inaccessible nuclear level of the daughter nuclide. It was proposed to study a nuclide where this decay mode was competing with continuum-state beta-decay, in order to measure their respective branchings. The ratio βb/βc could also be evaluated for the first time. 207Tl was chosen due to its high atomic number, and Q-value of about 1.4 MeV, small enough to enhance the βb probability and large enough to allow the use of time-resolved Schottky Mass Spectrometry (SMS) to study the evolution of mother and bound-state beta-decay daughter ions. The decay properties of the ground state and isomeric state of 207Tl81+ have been investigated at the GSI accelerator facility in two separate experiments. For the first time β-decay where the electron could go either to a bound state (atomic orbitals) and lead to 207Pb81+ as a daughter nuclide, or to a continuum state and lead to 207Pb82+, has been observed. The respective branchings of these two processes could be measured as well. The deduced total nuclear half-life of 255(17) s for 207Tl81+, was slightly modified with respect to the half-life of the neutral atom of 286(2) s. It was nevertheless in very good agreement with calculations based on the assumption that the beta-decay was following an allowed type of transition. The branching βb/βc=0.192(20), was also in very good agreement with the same calculations. The application of stochastic precooling allowed to observe in addition the 1348 keV short-lived isomeric state of 207Tl. The half-life of this isomeric state was measured as 1.47(32) s, which shows a small deviation compared to the half-life for

  11. CD1c-Related DCs that Express CD207/Langerin, but Are Distinguishable from Langerhans Cells, Are Consistently Present in Human Tonsils

    Science.gov (United States)

    De Monte, Anne; Olivieri, Charles-Vivien; Vitale, Sébastien; Bailleux, Sonanda; Castillo, Laurent; Giordanengo, Valérie; Maryanski, Janet L.; Segura, Elodie; Doglio, Alain

    2016-01-01

    Several subsets of dendritic cells (DCs) are present in the oropharyngeal tonsillar tissues and are thought to behave as major actors in development and regulation of immunity by acting as a first line of recognition for airborne and alimentary antigens. We previously discovered in human adult tonsils infected with Epstein–Barr virus (EBV), a subset of DCs that expressed langerin/CD207, a lectin usually recognized as a hallmark of epidermal Langerhans cells (LCs). In the present study, we analyzed the content of several child and adult tonsils in order to characterize in more detail the phenotype of these tonsillar CD207-expressing DCs (tCD207 DCs) and to compare it with that of other human DC subsets. We showed that all the human tonsils studied (n = 12) contained significant proportions of tCD207 DCs among tonsillar cells expressing HLA-DR. Moreover, the presence of tCD207 DCs in tonsils from young children free of EBV infection indicated that these cells could be established early in the tonsil independently of EBV infection. We also showed that tCD207 DCs, that were found mainly located within the tonsillar lymphoid stroma, were distinguishable from LCs by the level of expression of CD1a and EpCAM, and also from human inflammatory DCs by the lack of CD1a, CD206, and CD14 expression. Detailed analysis of cell surface DC markers showed that tCD207 DCs were unrelated to CD141+ DCs or macrophages, but defined a subtype of tonsillar DCs closely related to myeloid resident CD1c DCs. Since it was established that blood CD1c myeloid DCs exhibit plasticity and are capable of expressing CD207 notably in the presence of inflammatory cytokines, it is tempting to speculate that CD207+ CD1c+ DCs may play a specific immune role. PMID:27252701

  12. 代谢综合征207例患者健康管理的对比分析%Health management and metabolic syndrome in 207 employees

    Institute of Scientific and Technical Information of China (English)

    夏燕妮; 姜海伟; 李晨; 翟莎

    2011-01-01

    Objective To analyze the effects of health management of metabolic syndrome on the control of related risk factors. Methods A total of 430 patients diagnosed with metabolic syndrome in 2008completed questionnaire and before randomly assigned to the health management group ( n = 207 ) and the control group (n=223). One year later, all the participants were investigated for the risk factors of food intake, cigarette smoking, alcohol consumption, staying-up and emotion, and the changes of body mass index ( BMI), blood pressure ( BP), triglyceride (TG), high-density lipoprotein cholesterol (HDL) and fasting blood glucose (FBG). Student's t test and x2 test were used for data analysis. Results For the health management group, the incidence of high-salt, high-fat and high-sugar intake, overtake of food, lack of physical exercises,staying-up and alcohol drinking was significantly decreased at 1 year (P < 0. 05 ), when compared with baseline and the control group ( both P < 0. 05 ). For the health management group, BMI,systolic blood pressure (SBP),TG and FBG was improved at 1 year (P<0. 05). In comparison with the control group, BMI, SBP, diastolic blood pressure (DBP),TG and FBG of the management group were significantly improved (P < 0. 05 ). Conclusions Patients with metabolic syndrome may have better treatment compliance after receiving systematized and individualized health management.%目的 通过对武汉市某单位职工代谢综合征的健康管理效果观察,对比分析健康管理对于相关危险因素的发生率及代谢综合征相关指标的影响.方法 将2008年某单位体检中诊断为代谢综合征430例患者,通过问卷调查收集的健康信息进行健康风险因素分析;通过随机分组将207例自愿参与健康管理者作为管理组,管理组给予系统化的健康管理,其余223例作为对照组,仅给予一般性的健康指导及建议,一年后通过再次体检及问卷调查结果对比分析饮食、吸烟

  13. Astatination of closo-dodecaborate(2-) anion

    Czech Academy of Sciences Publication Activity Database

    Orlova, A.; Lebeda, Ondřej; Tolmachev, V.; Lundquist, H.; Carlsson, J.; Sjöberg, S.

    Cambridge : The Royal Society of Chemistry , 2000 - (Davidson, M.; Hughes, A.; Marder, T.; Wade , K.), s. 144-147 [Conference "Contemporary Boron Chemistry ". Durham (GB), 11.07.1999-15.07.1999] Institutional research plan: CEZ:AV0Z1048901 Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  14. Neutron total cross sections of 204Pb, 206Pb, 207Pb and 208Pb and the neutron electric polarizability

    International Nuclear Information System (INIS)

    The neutron total cross sections have been measured for lead isotopes 208Pb, 206Pb and 207Pb in the range from 1 eV to 20 keV and for 204Pb in the range from 1 eV to 100 eV using the time-of-flight facility GNEIS in Gatchina. An accuracy of the measured neutron total cross section (Δσ/σ) is about 10-3 for 208Pb, 10-2 for 206Pb and 207Pb, 5·10-2 for 204Pb. An estimated value of the neutron electric polarizability from analysis of total cross section of 208Pb is αn=(2.4 ± 1.1)·10-3fm3. (author)

  15. The separation of 65Zn from 113Sn and 207Bi radioisotopes by amalgam exchange and electro-analytical methods

    International Nuclear Information System (INIS)

    In this study, by using amalgam-exchange and electro-analytical methods, the separation of 65Zn radioisotope from a solution containing either one or both of the 113Sn and 207Bi radioisotopes were investigated. The radioisotopes were drawn into Zn-amalgam from the solution at first, and then 65Zn was recovered from the amalgam through back-electrolysis. No detectable contamination was observed and the recovery efficiency was found to be around 75%. (author)

  16. Energy resolution for gamma-rays and electrons from 207Bi in liquid Xe doped with TEA

    International Nuclear Information System (INIS)

    The energy resolution for γ-rays and conversion electrons electrons from 207 Bi has been studied by using a liquid xenon ionization chamber doped with photoionizing dopant TEA. Althought a significant improvement in the resolution is found at a low electric field by doping with TEA, improvement at a high electric field was not observed in marked contrast to a 'δ-ray recombination model'. (orig.)

  17. G 207-9 and LP 133-144: light curve analysis and asteroseismology of two ZZ Ceti stars

    CERN Document Server

    Bognár, Zs; Molnár, L; Pápics, P I; Plachy, E; Verebélyi, E; Sódor, Á

    2016-01-01

    G 207-9 and LP 133-144 are two rarely observed ZZ Ceti stars located in the middle and close to the blue edge of the ZZ Ceti instability domain, respectively. We aimed to observe them at least during one observing season at Konkoly Observatory with the purpose of extending the list of known pulsation modes for asteroseismic investigations and detect any significant changes in their pulsational behaviour. We determined five and three new normal modes of G 207-9 and LP 133-144, respectively. In LP 133-144, our frequency analysis also revealed that at least at three modes there are actually triplets with frequency separations of ~4 microHz. The rotational period of LP 133-144 based on the triplets is ~42 h. The preliminary asteroseismic fits of G 207-9 predict Teff=12 000 or 12 400 K and M*=0.855-0.870 MSun values for the effective temperature and mass of the star, depending on the assumptions on the spherical degree (l) values of the modes. These results are in agreement with the spectroscopic determinations. I...

  18. Subluxation injuries of maxillary primary anterior teeth: epidemiology and prognosis of 207 traumatized teeth.

    Science.gov (United States)

    Fried, I; Erickson, P; Schwartz, S; Keenan, K

    1996-01-01

    This study investigated the epidemiology, sequelae, and prognosis of subluxation injuries to the maxillary primary anterior dentition. Data were collected from dental records at the Montreal Children's Hospital, Montreal, Canada, of patients sustaining trauma between 1982 and 1993. The study group consisted of 207 teeth in 134 patients, 81 males and 53 females. The age of the patients ranged from 0.8 years to 7.5 years, with a mean of 3.5 years. The highest incidence of trauma was in males between the ages of 3 and 4 years, and in females between 1 and 3 years. The highest incidence of trauma (66.2%) involved the primary central incisors. The most common cause of trauma (52%) was simple falls indoors. Occlusal or periapical radiographs were the radiographic view of choice unless an anterior nasal spine fracture was suspected, in which case a lateral projection was exposed. Approximately 64% of the study teeth had a mobility ranging from 0.6 to 1.5 mm. Treatment varied from no treatment (80% of teeth) to extraction. Post-traumatic evaluations were distributed into six common time intervals used by dentists for follow up. The results indicated that patient discomfort and occlusal interference were not common. Discoloration and pulpal calcification increased with time. Mobility decreased with time, with the majority of teeth returning to a normal physiologic range. External resorption may have been present, but was rare. Treatment or antibiotics were rarely needed at follow-up visits. Overall, these teeth responded positively, and there was a low morbidity associated with subluxation injuries. PMID:8710718

  19. Detection of lead via lead-207m using cyclic activation and a modified sum-coincidence system

    International Nuclear Information System (INIS)

    Samples containing lead were irradiated in a reactor, counted on a detector, and the process repeated for an optimum number of cycles in order to determine the concentration of the element present. The 0.8s isomer of /sup 207m/Pb was detected using two 7.5 cm x 7.5 cm NaI (Tl) crystals operating in a modified sum-coincidence system. The efficiency and resolution of the system were measured using a standard source. The sensitivity and detection limits for lead in various matrices of environmental interest were obtained. The sensitivity in an interference free matrix was found to be 5 μg

  20. Betulinic Acid Derivatives NVX-207 and B10 for Treatment of Glioblastoma—An in Vitro Study of Cytotoxicity and Radiosensitization

    Directory of Open Access Journals (Sweden)

    Matthias Bache

    2014-10-01

    Full Text Available Betulinic acid (BA, a pentacyclic triterpene, represents a new therapeutic substance that has potential benefits for treating glioblastoma. Recently, new strategies for producing BA derivatives with improved properties have evolved. However, few studies have examined the combination of BA or BA derivatives using radiotherapy. The effects of two BA derivatives, NVX-207 and B10, on cellular and radiobiological behavior were analyzed using glioblastoma cell lines (U251MG, U343MG and LN229. Based on IC50 values under normoxic conditions, we detected a 1.3–2.9-fold higher cytotoxicity of the BA derivatives B10 and NVX-207, respectively, compared to BA. Incubation using both BA derivatives led to decreased cell migration, cleavage of PARP and decreased protein expression levels of Survivin. Weak radiation sensitivity enhancement was observed in U251MG cells after treatment with both BA derivatives. The enhancement factors at an irradiation dose of 6 Gy after treatment with 5 µM NVX-207 and 5 µM B10 were 1.32 (p = 0.029 and 1.55 (p = 0.002, respectively. In contrast to BA, neither NVX-207 nor B10 had additional effects under hypoxic conditions. Our results suggest that the BA derivatives NVX-207 and B10 improve the effects of radiotherapy on human malignant glioma cells, particularly under normoxic conditions.

  1. Betulinic acid derivatives NVX-207 and B10 for treatment of glioblastoma--an in vitro study of cytotoxicity and radiosensitization.

    Science.gov (United States)

    Bache, Matthias; Bernhardt, Stephan; Passin, Sarina; Wichmann, Henri; Hein, Anja; Zschornak, Martin; Kappler, Matthias; Taubert, Helge; Paschke, Reinhard; Vordermark, Dirk

    2014-01-01

    Betulinic acid (BA), a pentacyclic triterpene, represents a new therapeutic substance that has potential benefits for treating glioblastoma. Recently, new strategies for producing BA derivatives with improved properties have evolved. However, few studies have examined the combination of BA or BA derivatives using radiotherapy. The effects of two BA derivatives, NVX-207 and B10, on cellular and radiobiological behavior were analyzed using glioblastoma cell lines (U251MG, U343MG and LN229). Based on IC50 values under normoxic conditions, we detected a 1.3-2.9-fold higher cytotoxicity of the BA derivatives B10 and NVX-207, respectively, compared to BA. Incubation using both BA derivatives led to decreased cell migration, cleavage of PARP and decreased protein expression levels of Survivin. Weak radiation sensitivity enhancement was observed in U251MG cells after treatment with both BA derivatives. The enhancement factors at an irradiation dose of 6 Gy after treatment with 5 µM NVX-207 and 5 µM B10 were 1.32 (p=0.029) and 1.55 (p=0.002), respectively. In contrast to BA, neither NVX-207 nor B10 had additional effects under hypoxic conditions. Our results suggest that the BA derivatives NVX-207 and B10 improve the effects of radiotherapy on human malignant glioma cells, particularly under normoxic conditions. PMID:25361208

  2. Betulinic Acid Derivatives NVX-207 and B10 for Treatment of Glioblastoma—An in Vitro Study of Cytotoxicity and Radiosensitization

    Science.gov (United States)

    Bache, Matthias; Bernhardt, Stephan; Passin, Sarina; Wichmann, Henri; Hein, Anja; Zschornak, Martin; Kappler, Matthias; Taubert, Helge; Paschke, Reinhard; Vordermark, Dirk

    2014-01-01

    Betulinic acid (BA), a pentacyclic triterpene, represents a new therapeutic substance that has potential benefits for treating glioblastoma. Recently, new strategies for producing BA derivatives with improved properties have evolved. However, few studies have examined the combination of BA or BA derivatives using radiotherapy. The effects of two BA derivatives, NVX-207 and B10, on cellular and radiobiological behavior were analyzed using glioblastoma cell lines (U251MG, U343MG and LN229). Based on IC50 values under normoxic conditions, we detected a 1.3–2.9-fold higher cytotoxicity of the BA derivatives B10 and NVX-207, respectively, compared to BA. Incubation using both BA derivatives led to decreased cell migration, cleavage of PARP and decreased protein expression levels of Survivin. Weak radiation sensitivity enhancement was observed in U251MG cells after treatment with both BA derivatives. The enhancement factors at an irradiation dose of 6 Gy after treatment with 5 µM NVX-207 and 5 µM B10 were 1.32 (p = 0.029) and 1.55 (p = 0.002), respectively. In contrast to BA, neither NVX-207 nor B10 had additional effects under hypoxic conditions. Our results suggest that the BA derivatives NVX-207 and B10 improve the effects of radiotherapy on human malignant glioma cells, particularly under normoxic conditions. PMID:25361208

  3. 2psub(1/2) and 2psub(3/2) proton states of sup(207)Tl

    International Nuclear Information System (INIS)

    Recent experimental results on the deep proton hole states of sup(207)Tl indicate the presence of 2psub(1/2) and 2psub(3/2) states within the excitation region of 3.8 to 14.5 MeV. An entire distribution of these two deep hole states is obtained through the hole-core vibrational scheme after obtaining the zero order shell model energies of these two hole states from the numerical solution of the Schroedinger equation. The renormalized shell model energies of the entire proton hole states so far known from the latest experiments can be used to obtain the proton magicity in the super heavy region. (author). 12 refs., 2 tabs

  4. Langerhans cells (CD1a and CD207), dermal dendrocytes (FXIIIa) and plasmacytoid dendritic cells (CD123) in skin lesions of leprosy patients.

    Science.gov (United States)

    Hirai, Kelly Emi; Aarão, Tinara Leila de Sousa; Silva, Luciana Mota; de Sousa, Jorge Rodrigues; de Souza, Juarez; Dias, Leonidas Braga; Oliveira Carneiro, Francisca Regina; Fuzii, Hellen Thais; Quaresma, Juarez Antonio Simões

    2016-02-01

    The clinical course of infection with Mycobacterium leprae varies widely and depends on the pattern of the host immune response. Dendritic cells play an important role in the activation of the innate and adaptive immune system and seem to be essential for the development of the disease. To analyze the presence of epidermal dendritic cells (CD1a and CD207), plasmacytoid dendritic cells (CD123) and dermal dendrocytes (factor XIIIa) in lesion fragments of leprosy patients, skin samples from 30 patients were studied. These samples were submitted to immunohistochemistry against CD1a, CD207, FXIIIa, and CD123. The results showed a larger number of Langerhans cells, detected with the CD1a or CD207 marker, dermal dendrocytes and plasmacytoid dendritic cells in patients with the tuberculoid form. A positive correlation was observed between the Langerhans cell markers CD1a and CD207 in both the tuberculoid and lepromatous forms, and between Langerhans cells and dermal dendrocytes in samples with the tuberculoid form. The present results indicate the existence of a larger number of dendritic cells in patients at the resistant pole of the disease (tuberculoid) and suggest that the different dendritic cells studied play a role, favoring an efficient immune response against infection with M. leprae. PMID:26639680

  5. 33 CFR 207.170d - Taylor Creek, navigation lock (S-193) across the entrance to Taylor Creek at Lake Okeechobee...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Taylor Creek, navigation lock (S..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.170d Taylor Creek, navigation lock..., and navigation. (a) The owner of or agency controlling the lock shall not be required to operate...

  6. Precision spectroscopy of the 207Pb19F molecule: Implications for measurement of P-odd and T-odd effects

    International Nuclear Information System (INIS)

    Here we report precision microwave spectroscopy of pure rotational transitions of the 207Pb19F isotopologue. We use these data to make predictions of the sensitivity of the molecule to P-odd, T-even and P-odd, T-odd effects.

  7. Extended disease-free interval of 6 years in a recurrent glioblastoma multiforme patient treated with G207 oncolytic viral therapy

    Directory of Open Access Journals (Sweden)

    Whisenhunt Jr TR

    2015-01-01

    Full Text Available Thomas R Whisenhunt Jr, Kiran F Rajneesh, James R Hackney, James M Markert Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA Background: Glioblastoma multiforme (GBM is a relentless primary central nervous system malignancy that remains resistant to conventional therapy despite major advances in clinical neurooncology. This report details the case of a patient who had failed conventional treatment for recurrent GBM and was ultimately treated with a genetically engineered herpes simplex virus (HSV type 1 vector, G207. Methods: Case report detailing the outcomes of one patient enrolled into the gene therapy arm of the Neurovir G207 protocol whereby stereotactic injection of 120 µL G207 viral suspension containing 1×107 plaque-forming units (or active viral particles was made into the enhancing region of the tumor. Results: In this patient, despite aggressive surgical resection, adjuvant radiotherapy and chemotherapy, tumor progression occurred. However, with G207 oncolytic therapy and brief exposures to second and third treatments, this patient had an extended survival time of 7.5 years and a 6-year apparent disease-free interval, an extraordinarily unusual finding in the pretemozolomide era. Conclusion: With minimal adjunctive chemotherapy, including one course of temozolomide, one course of procarbazine, and four cycles of irinotecan, the patient survived over 7 years before the next recurrence. Addition of G207 to this patient’s traditional therapy may have been the critical treatment producing her prolonged survival. This report demonstrates the potential for long-term response to a one-time treatment with oncolytic HSV and encourages continued research on oncolytic viral therapy for GBM. Keywords: oncolytic virotherapy, malignant glioma, tumor, herpes simplex, HSV-1, immunotherapy

  8. Antimicrobial resistance of 207 strains of pathogenic bacteria causing surgical nosocomiai infections and intervention measures%外科207株医院感染病原菌的耐药性与干预措施

    Institute of Scientific and Technical Information of China (English)

    余晓燕; 张建菊; 陈慧; 周谦

    2011-01-01

    OBJECTIVE To 'study the constituent rate and antimicrobial resistance status of pathogenic bacteria causing surgical nosocomial infections and adopted the intervention measurement to prevent nosocomial infection. METHODS The statistical data were investigated. Based on Referring to National Guide to Clinical Laboratory Procedures, bacterial culturation and drug sensitivity testing were performed for the secretion from infected wounds. RESULTS Among 207 pathogens causing surgical infection, the isolating rates were as follows: Pseudo-monas aeruginosa (26. 6‰, Slaphylococcus aureus (22.7%), Escherichia coli (16.4%) and Klebsiella pneu-moniae (14. 5%). The drug sensitivity testing results indicated that except for 92. 7% -100. 0% of sensitivity rate of carbapenem antibiotics against Gram-negative bacilli and 100. 0% of sensitivity rate of glycopeptide antibiotics against S. Aureus, pathogenic bacteria had more serious antimicrobial resistance. CONCLUSION The effective intervention measures should be taken to restrain the increasing tendency of antimicrobial resistance.%目的 了解山区医院外科感染病原菌的构成比及耐药现状,采取干预措施预防医院感染.方法调查外科感染患者病历资料,外科感染性分泌物细菌培养和药敏试验严格按照《全国临床检验操作规程》进行.结果207株外科感染病原菌中,分离率依次为铜绿假单胞菌26.6%、金黄色葡萄球菌22.7%、大肠埃希菌16.4%、肺炎克雷伯菌14.5%;药敏结果显示,除革兰阴性杆菌对碳青霉烯类抗菌药物敏感率为92.7%~100.0%、金黄色葡萄球菌对糖肽类抗菌药物敏感率为100.0%以外,病原菌均产生了较为严重的耐药性.结论 医院应采取切实有效的干预措施,遏制细菌耐药性快速增长的不良趋势.

  9. Evaluation of the role of CD207 on Langerhans cells in a murine model of atopic dermatitis by in situ imaging using Cr:forsterite laser-based multimodality nonlinear microscopy

    Science.gov (United States)

    Lee, Jyh-Hong; Tsai, Ming-Rung; Sun, Chi-Kuang; Chiang, Bor-Luen

    2012-11-01

    Atopic dermatitis (AD) is an allergic inflammatory disease of skin. It remains unclear that CD207 of Langerhans cells (LCs) plays a central role in the development of allergic sensitization. There is little data on LCs within the microenviroment in vivo. We used a murine model of epicutaneous (EC) ovalbumin (OVA) sensitization inducing an inflammatory skin resembling AD to explore the role of CD207 in the pathogenesis of AD. Cr:forsterite laser-based multimodality nonlinear microscopy was applied for in situ imaging. Peritoneal injections of Alexa Fluor 647-rat anti-mouse CD207 into mice were performed to specifically trace the LCs. Peritoneal injections of OVA-Alexa Fluor 647 conjugate into mice were performed to specifically trace the OVA. We found that combining Alexa Fluor fluorescent probes with multimodality nonlinear microscopy permitted the unequivocal in situ imaging of CD207-expressing LCs. The relevant time-course, expressional, and functional studies reveal that CD207 of LCs plays an essential role during the induction of EC sensitization. We establish and validate that Cr:forsterite laser-based multimodality nonlinear microscopy is applicable for the specific detection of labeled mAb-bound LCs and labeled antigen. We suggest that CD207-expressing LCs initiate the allergic response through the CD207 mediated epicutaneous sensitization associated with the development of AD.

  10. First direct observation of bound-state beta-decay. Measurements of branching and lifetime of {sup 207}Tl{sup 81+} fragments

    Energy Technology Data Exchange (ETDEWEB)

    Boutin, D.

    2005-08-01

    The first experimental observation of bound-state beta-decay showed, that due solely to the electron stripping, a stable nuclide, e.g. {sup 163}Dy, became unstable. Also a drastic modification of the half-life of bare {sup 187}Re, from 4.12(2) x 10{sup 10} years down to 32.9(20) years, could be observed. It was mainly due to the possibility for the mother nuclide to decay into a previously inaccessible nuclear level of the daughter nuclide. It was proposed to study a nuclide where this decay mode was competing with continuum-state beta-decay, in order to measure their respective branchings. The ratio {beta}{sub b}/{beta}{sub c} could also be evaluated for the first time. {sup 207}Tl was chosen due to its high atomic number, and Q-value of about 1.4 MeV, small enough to enhance the {beta}{sub b} probability and large enough to allow the use of time-resolved Schottky Mass Spectrometry (SMS) to study the evolution of mother and bound-state beta-decay daughter ions. The decay properties of the ground state and isomeric state of {sup 207}Tl{sup 81+} have been investigated at the GSI accelerator facility in two separate experiments. For the first time {beta}-decay where the electron could go either to a bound state (atomic orbitals) and lead to {sup 207}Pb{sup 81+} as a daughter nuclide, or to a continuum state and lead to {sup 207}Pb{sup 82+}, has been observed. The respective branchings of these two processes could be measured as well. The deduced total nuclear half-life of 255(17) s for {sup 207}Tl{sup 81+}, was slightly modified with respect to the half-life of the neutral atom of 286(2) s. It was nevertheless in very good agreement with calculations based on the assumption that the beta-decay was following an allowed type of transition. The branching {beta}{sub b}/{beta}{sub c}=0.192(20), was also in very good agreement with the same calculations. The application of stochastic precooling allowed to observe in addition the 1348 keV short-lived isomeric state of {sup

  11. Liptinite as an indicator of environmental changes during formation of coal seam No. 207 (Upper Silesia, Poland)

    Energy Technology Data Exchange (ETDEWEB)

    Jelonek, I.; Kruszewska, K.J.; Filipiak, P. [Faculty of Earth Sciences, University of Silesia, Bedzinska Street, 60, 41-200, Sosnowiec (Poland)

    2007-08-01

    The coal seam No. 207 was a subject of palynological and petrographic studies. According to the results of the vitrinite random reflectance measurements supplemented by moisture and calorific value determinations, the rank of this coal is matching the boundary between sub-bituminous and bituminous coals. The aim was to reconstruct the environmental conditions during the biochemical stage of seam formation, as well as the facies development throughout the seam profile. The maceral (incident and fluorescence mode) and microlithotype compositions (incident light) supplemented by palynological analyses, show that there were two main facies developments. In the authors opinion, they correspond with a phase of ombrogenous, raised bog marked by the presence of crassidurite with Densosporites variabilis and a wet-forest swamp phase represented by vitrite and clarite with more diverse spore assemblage including densospores. Other minor but distinctive sediments, a cannel layer and a reeds facies, both occurring in the lower part of the seam. Above the tonstein horizon, a dry forest type of sedimentation is recognized. (author)

  12. Statistics of 207 Lya Emitters at a Redshift Near 7: Constraints on Reionization and Galaxy Formation Models

    CERN Document Server

    Ouchi, Masami; Furusawa, Hisanori; SAITO, Tomoki; Yoshida, Makiko; Akiyama, Masayuki; Ono, Yoshiaki; Yamada, Toru; Ota, Kazuaki; Kashikawa, Nobunari; Iye, Masanori; Kodama, Tadayuki; Okamura, Sadanori; Simpson, Chris; Yoshida, Michitoshi

    2010-01-01

    We present Lya luminosity function (LF), clustering measurements, and Lya line profiles based on the largest sample, to date, of 207 Lya emitters (LAEs) at z=6.6 on the 1 deg^2 sky of Subaru/XMM-Newton Deep Survey (SXDS) field. Our z=6.6 Lya LF including cosmic variance estimates yields the best-fit Schechter parameters of phi*=8.5 +3.0/-2.2 x10^(-4) Mpc^(-3) and L*(Lya)=4.4 +/-0.6 x10^42 erg s^(-1) with a fixed alpha=-1.5, and indicates a decrease from z=5.7 at the >~90% confidence level. However, this decrease is not large, only =~30% in Lya luminosity, which is too small to be identified in the previous studies. A clustering signal of z=6.6 LAEs is detected for the first time. We obtain the correlation length of r_0=2-4 h^(-1) Mpc and bias of b=3-5, and find no significant boost of clustering amplitude by reionization at z=6.6. The average hosting dark halo mass inferred from clustering is 10^10-10^11 Mo, and duty cycle of LAE population is roughly ~1% albeit with large uncertainties. The average of our hi...

  13. Determination of 206/207Pb isotope ratios by ICP-MS in particulate matter from the North Sea environment

    International Nuclear Information System (INIS)

    The determination of lead isotope ratios can be used for source and pathway characterization of lead in the environment. The suitability of inductively coupled mass spectrometry (ICP-MS) was evaluated for the measurement of 206/207Pb isotope ratios in several marine compartments as marine aerosols from different source regions and suspended particulate matter from the North Sea. Two different ICP-MS systems were used to carry out these investigations. First optimization studies have been performed to yield a sufficient precision (RSD<0.5%) incombination with a reasonable measuring time. This study has been carried out using the standard reference material NBS 981 with certified lead isotope ratios. Furthermore, it could be shown for marine environmental samples, that a precision of less than 0.5% RSD is attainable for counting rates of above approximately 50000 cps. As the following measurements of lead isotope ratios in marine aerosols from main source regions surrounding the North Sea demonstrated, this precision is sufficient to determine significant differences due to the origin of atmospheric lead. The analysis of aerosol samples revealed isotope ratios varying from as low as 1.10, which is close to that ratio for leaded gasoline in Europe to near background (modern lead) values of 1.20. The lead isotope ratios for the investigated suspended particulate matter ranges between 1.13 and 1.18. These values can be related to the solid discharge, the urban density and anthropogenic activity of the drainage basin. (orig.)

  14. Ion microprobe 207Pb/206Pb zircon ages for gneiss-granitoid rocks from Bundelkhand massif: evidence for Archaean components

    International Nuclear Information System (INIS)

    Radiometric 207Pb/206Pb ages of individual zircons from the Bundelkhand massif, central India, have been determined by an ion microprobe. Samples from various major litho-units, viz. the granite gneiss, hornblende-, biotite- and leuco-granitoid are included in this study. The results provide evidence for the presence of Archaean crustal components within this massif. Zircons with ages of 3.0 to 3.2 Ga occur as xenocrysts in a sample of granite gneiss from Lalitpur having a minimum formation age of 2.5 Ga. Another sample of a highly deformed gneiss from Babina has a well-defined age of 2.7 Ga. Emplacement of hornblende-granitoid and biotite-granitoid took place in quick succession at ∼ 2.5 Ga. No firm age for the youngest plutonic component, the leuco-granitoid, could be obtained due to poor recovery of zircons suitable for analysis. The geochronological data confirm the suggestion, based on geochemical studies, that the gneisses and the granitoids in this region represent Archaean and post-Archaean components respectively. (author)

  15. Moessbauer study of the sintered Mn0.70Zn0.23Fe2.07O4

    International Nuclear Information System (INIS)

    The samples of Mn-Zn ferrite having characteristic of low power expense, were obtained. Its structure and phase transformation in pre-sintering process by means of Moessbauer spectroscopy were studied. The conclusions are as follows: (1) The sample sintered at high temperature contains excess iron, has the typical Moessbauer parameters. Its formula can be written as Mn0.70Zn0.23Fe2.07O4. (2) The doublet sub-spectrum arise during thermal transformation varies with the process of the phase transformation. It serves as a mark of the course of the transformation. (3) The pre-sintering temperature 1040 degree C has primarily approached to the earlier stage of phase transformation to form Mn-Zn ferrite. (4) The breaks in heating and pre-sintering repeatedly at low temperature are unfavourable to phase transformation. (5) the Moessbauer parameters of the raw material Fe2O3 are markedly different from that in literature. There is obvious influence on the samples pre-sintered but little influence on the sample sintered at high temperature

  16. ECT结合高频超声诊断甲状腺癌207例分析

    Institute of Scientific and Technical Information of China (English)

    王锦锋; 陈胜江

    2009-01-01

    目的:探讨.ECT和高频超声检查对甲状腺癌的诊断价值.方法:对207例甲状腺癌患者的临床资料进行回顾性分析,根据最终病理结果,总结ECT和高频超声诊断甲状癌的符合率.结果:单纯的ECT或高频超声检查甲状腺癌与术后病理诊断有很大差异,诊断符合率分别为74.4%及72.9%.ECT和高频超声联合诊断甲状腺癌的符合率为87.9%.结论:术前ECT及高频超声检查,能给医生一个直观的影像学诊断,但单项检查常不能反映甲状腺肿块的状况,ECT和高频超声联合对甲状癌具有较大的定性诊断价值.

  17. Vector and tensor analyzing powers in the 208Pb(vector d,t)207Pb reaction at 200 and 360 MeV

    International Nuclear Information System (INIS)

    Cross-sections, vector and tensor analyzing powers for the main levels in 207Pb have been measured via the 208Pb (d,t) 207Pb reaction at 200 and 360 MeV incident energies. Ay and Ayy spin observables allow a clear identification of the valence levels, especially at 200 MeV. The results are compared with finite range DWBA calculations using the Paris projectile-ejectile form factor including the S and D components. The analysis shows a large effect of the D component on the tensor analyzing powers at the most forward angles. At both energies, the spin part of the deuteron optical potential is very important to describe the analyzing powers and especially Ayy. The good description of all observables at 200 MeV allows this reaction to be used as a spectroscopic tool

  18. Draft genome sequence of a multidrug-resistant New Delhi metallo-β-lactamase NDM-1-producing Acinetobacter pittii sequence type 207 isolate from China.

    Science.gov (United States)

    Wang, Jianfeng; Wu, Liyan; Xu, Liqun; Chen, Yu; Chen, Yan

    2016-09-01

    The increasing emergence of carbapenem-resistant Acinetobacter spp. worldwide has resulted in the limited availability of effective antimicrobial agents and has become a major public health concern. In this study, the draft genome sequence of Acinetobacter pittii TCM292 belonging to sequence type 207 (ST207), a multidrug-resistant (MDR) isolate harbouring the New Delhi metallo-β-lactamase blaNDM-1 gene, was determined using an Illumina HiSeq™ 2000 platform. The genome sequence was analysed by bioinformatics methods. The A. pittii TCM292 genome size was estimated to be 3791758bp with 3486 predicted coding regions. These data might facilitate further understanding of the specific genomic features of MDR A. pittii in China. PMID:27530847

  19. Selective induction of apoptosis by the cytotoxic analog AN-207 in cells expressing recombinant receptor for luteinizing hormone-releasing hormone

    OpenAIRE

    Danila, Daniel C; Schally, Andrew V.; Nagy, Attila; Alexander, Joseph M

    1999-01-01

    The selectivity of ligands specific for certain cells can be used to preferentially target chemotherapeutic compounds to neoplastic cells. Human breast, ovarian, endometrial, and prostatic cancers express receptors that can mediate the delivery of targeted cytotoxic compounds to neoplastic cells. Recently, a potent derivative of 2-pyrrolinodoxorubicin (AN-201) conjugated to [d-Lys6] luteinizing hormone-releasing hormone (LH-RH) (AN-207), was demonstrated to be less toxic than the nonconjugate...

  20. A Study of $b\\overline{b}$ Production in $e^{+}e^{-}$ Collisions at $\\sqrt{s}$ = 130-207 GeV

    CERN Document Server

    Abdallah, J; Adam, W; Adzic, P; Albrecht, T; Alemany-Fernandez, R; Allmendinger, T; Allport, P.P; Amaldi, U; Amapane, N; Amato, S; Anashkin, E; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W-D; Arnoud, Y; Ask, S; Asman, B; Augustin, J.E; Augustinus, A; Baillon, P; Ballestrero, A; Bambade, P; Barbier, R; Bardin, D; Barker, G.J; Baroncelli, A; Battaglia, M; Baubillier, M; Becks, K-H; Begalli, M; Behrmann, A; Ben-Haim, E; Benekos, N; Benvenuti, A; Berat, C; Berggren, M; Bertrand, D; Besancon, M; Besson, N; Bloch, D; Blom, M; Bluj, M; Bonesini, M; Boonekamp, M; Booth, P.S.L; Borisov, G; Botner, O; Bouquet, B; Bowcock, T.J.V; Boyko, I; Bracko, M; Brenner, R; Brodet, E; Bruckman, P; Brunet, J.M; Buschbeck, B; Buschmann, P; Calvi, M; Camporesi, T; Canale, V; Carena, F; Castro, N; Cavallo, F; Chapkin, M; Charpentier, Ph; Checchia, P; Chierici, R; Chliapnikov, P; Chudoba, J; Chung, S.U; Cieslik, K; Collins, P; Contri, R; Cosme, G; Cossutti, F; Costa, M.J; Crennell, D; Cuevas, J; D'Hondt, J; da Silva, T; Da Silva, W; Della Ricca, G; De Angelis, A; De Boer, W; De Clercq, C; De Lotto, B; De Maria, N; De Min, A; de Paula, L; Di Ciaccio, L; Di Simone, A; Doroba, K; Drees, J; Eigen, G; Ekelof, T; Ellert, M; Elsing, M; Espirito Santo, M.C; Fanourakis, G; Fassouliotis, D; Feindt, M; Fernandez, J; Ferrer, A; Ferro, F; Flagmeyer, U; Foeth, H; Fokitis, E; Fulda-Quenzer, F; Fuster, J; Gandelman, M; Garcia, C; Gavillet, Ph; Gazis, E; Gokieli, R; Golob, B; Gomez-Ceballos, G; Goncalves, P; Graziani, E; Grosdidier, G; Grzelak, K; Guy, J; Haag, C; Hallgren, A; Hamacher, K; Hamilton, K; Haug, S; Hauler, F; Hedberg, V; Hennecke, M; Hoffman, J; Holmgren, S-O; Holt, P.J; Houlden, M.A; Jackson, J.N; Jarlskog, G; Jarry, P; Jeans, D; Johansson, E.K; Jonsson, P; Joram, C; Jungermann, L; Kapusta, F; Katsanevas, S; Katsoufis, E; Kernel, G; Kersevan, B.P; Kerzel, U; King, B.T; Kjaer, N.J; Kluit, P; Kokkinias, P; Kourkoumelis, C; Kouznetsov, O; Krumstein, Z; Kucharczyk, M; Lamsa, J; Leder, G; Ledroit, F; Leinonen, L; Leitner, R; Lemonne, J; Lepeltier, V; Lesiak, T; Liebig, W; Liko, D; Lipniacka, A; Lopes, J.H; Lopez, J.M; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J; Malek, A; Maltezos, S; Mandl, F; Marco, J; Marco, R; Marechal, B; Margoni, M; Marin, J-C; Mariotti, C; Markou, A; Martinez-Rivero, C; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Mazzucato, F; Mazzucato, M; McNulty, R; Meroni, C; Migliore, E; Mitaroff, W; Mjoernmark, U; Moa, T; Moch, M; Monig, Klaus; Monge, R; Montenegro, J; Moraes, D; Moreno, S; Morettini, P; Mueller, U; Muenich, K; Mulders, M; Mundim, L; Murray, W; Muryn, B; Myatt, G; Myklebust, T; Nassiakou, M; Navarria, F; Nawrocki, K; Nemecek, S; Nicolaidou, R; Nikolenko, M; Oblakowska-Mucha, A; Obraztsov, V; Olshevski, A; Onofre, A; Orava, R; Österberg, K; Ouraou, A; Oyanguren, A; Paganoni, M; Paiano, S; Palacios, J.P; Palka, H; Papadopoulou, Th.D; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Peralta, L; Perepelitsa, V; Perrotta, A; Petrolini, A; Piedra, J; Pieri, L; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Poireau, V; Pol, M.E; Polok, G; Pozdniakov, V; Pukhaeva, N; Pullia, A; Radojicic, D; Rebecchi, P; Rehn, J; Reid, D; Reinhardt, R; Renton, P; Richard, F; Ridky, J; Rivero, M; Rodriguez, D; Romero, A; Ronchese, P; Roudeau, P; Rovelli, T; Ruhlmann-Kleider, V; Ryabtchikov, D; Sadovsky, A; Salmi, L; Salt, J; Sander, C; Savoy-Navarro, A; Schwickerath, U; Sekulin, R; Siebel, M; Sisakian, A; Smadja, G; Smirnova, O; Sokolov, A; Sopczak, A; Sosnowski, R; Spassov, T; Stanitzki, M; Stocchi, A; Strauss, J; Stugu, B; Szczekowski, M; Szeptycka, M; Szumlak, T; Tabarelli, T; Tegenfeldt, F; Timmermans, J; Tkatchev, L; Tobin, M; Todorovova, S; Tome, B; Tonazzo, A; Tortosa, P; Travnicek, P; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Turluer, M-L; Tyapkin, I.A; Tyapkin, P; Tzamarias, S; Uvarov, V; Valenti, G; Van Dam, P; Van Eldik, J; van Remortel, N; Van Vulpen, I; Vegni, G; Veloso, F; Venus, W; Verdier, P; Verzi, V; Vilanova, D; Vitale, L; Vrba, V; Wahlen, H; Washbrook, A.J; Weiser, C; Wicke, D; Wickens, J; Wilkinson, G; Winter, M; Witek, M; Yushchenko, O; Zalewska, A; Zalewski, P; Zavrtanik, D; Zhuravlov, V; Zimin, N I; Zintchenko, A; Zupan, M

    2009-01-01

    Measurements are presented of R_b, the ratio of the b bbar cross-section to the q qbar cross-section in e+e- collisions, and the forward-backward asymmetry A^b_FB at twelve energy points in the range sqrt(s) = 130-207 GeV. These results are found to be consistent with the Standard Model expectations. The measurements are used to set limits on new physics scenarios involving contact interactions.

  1. First direct high-precision energy determination for the 8.4 and 20.7 keV nuclear transitions in {sup 169}Tm

    Energy Technology Data Exchange (ETDEWEB)

    Inoyatov, A.Kh. [JINR, Laboratory of Nuclear Problems, Dubna, Moscow Region (Russian Federation); National University, Institute of Applied Physics, Tashkent (Uzbekistan); Kovalik, A. [JINR, Laboratory of Nuclear Problems, Dubna, Moscow Region (Russian Federation); Nuclear Physics Institute of the ASCR, Rez near Prague (Czech Republic); Filosofov, D.V.; Perevoshchikov, L.L. [JINR, Laboratory of Nuclear Problems, Dubna, Moscow Region (Russian Federation); Rysavy, M. [Nuclear Physics Institute of the ASCR, Rez near Prague (Czech Republic); Gurov, Yu.B. [JINR, Laboratory of Nuclear Problems, Dubna, Moscow Region (Russian Federation); National Research Nuclear University MEPhI, Moscow (Russian Federation)

    2015-06-15

    Energies of 8410.1 ± 0.4, 20743.9 ± 0.3, and 63121.6 ± 1.2 eV were determined for the 8.4 keV M1 + E2, 20.7 keV M1 + E2, and 63.1 keV E1 nuclear transitions in {sup 169}Tm (generated in the EC decay of {sup 169}Yb), respectively, by means of the internal conversion electron spectroscopy. The {sup 169}Yb sources used were prepared by vacuum evaporation deposition on polycrystalline carbon and platinum foils as well as by ion implantation at 30keV into a polycrystalline aluminum foil. The relevant conversion electron spectra were measured by a high-resolution combined electrostatic electron spectrometer at 7 eV instrumental resoluition. Values of 0.0326(14) and 0.0259(17) were derived from our experimental data for the E2 admixture parameter δ (E2/M1) for the 8.4 and 20.7 keV transitions, respectively. A possible effect of nuclear structure on multipolarity of the 20.7 keV transition was also investigated. (orig.)

  2. 207-nm UV light - a promising tool for safe low-cost reduction of surgical site infections. I: in vitro studies.

    Directory of Open Access Journals (Sweden)

    Manuela Buonanno

    Full Text Available BACKGROUND: 0.5% to 10% of clean surgeries result in surgical-site infections, and attempts to reduce this rate have had limited success. Germicidal UV lamps, with a broad wavelength spectrum from 200 to 400 nm are an effective bactericidal option against drug-resistant and drug-sensitive bacteria, but represent a health hazard to patient and staff. By contrast, because of its limited penetration, ~200 nm far-UVC light is predicted to be effective in killing bacteria, but without the human health hazards to skin and eyes associated with conventional germicidal UV exposure. AIMS: The aim of this work was to test the biophysically-based hypothesis that ~200 nm UV light is significantly cytotoxic to bacteria, but minimally cytotoxic or mutagenic to human cells either isolated or within tissues. METHODS: A Kr-Br excimer lamp was used, which produces 207-nm UV light, with a filter to remove higher-wavelength components. Comparisons were made with results from a conventional broad spectrum 254-nm UV germicidal lamp. First, cell inactivation vs. UV fluence data were generated for methicillin-resistant S. aureus (MRSA bacteria and also for normal human fibroblasts. Second, yields of the main UV-associated pre-mutagenic DNA lesions (cyclobutane pyrimidine dimers and 6-4 photoproducts were measured, for both UV radiations incident on 3-D human skin tissue. RESULTS: We found that 207-nm UV light kills MRSA efficiently but, unlike conventional germicidal UV lamps, produces little cell killing in human cells. In a 3-D human skin model, 207-nm UV light produced almost no pre-mutagenic UV-associated DNA lesions, in contrast to significant yields induced by a conventional germicidal UV lamp. CONCLUSIONS: As predicted based on biophysical considerations, 207-nm light kills bacteria efficiently but does not appear to be significantly cytotoxic or mutagenic to human cells. Used appropriately, 207-nm light may have the potential for safely and inexpensively

  3. Efficacy observation of iron deficiency anemia prevention in 207 low birth weight infants%207例低出生体重儿预防缺铁性贫血的疗效观察

    Institute of Scientific and Technical Information of China (English)

    邵小飞; 刘杰; 郑娟

    2014-01-01

    Objective To observe the efficacy and adverse reactions of iron supplementation for preventing iron deficiency anemia of mild low birth weight infants at different ages, to provide reference for the prevention of iron deficiency anemia in low birth weight infant. Methods Totally 207 mild low birth weight infants were divided into 3 experimental groups (groupⅠ:starting iron supplement from the age of 2 weeks;groupⅡ:starting iron sup-plement from the age of 4 weeks; groupⅢ: starting iron supplement from the age of 2 months) and one control group (groupⅣ:without iron supplement) basing on the principle of parent informed consent. The iron supplement was 2 mg·kg-1·d-1 for subjects in the three experimental groups. Performed blood cell analysis of all subjects respec-tively at the beginning, age of 3 months and 6 months, compared the HGB, MCV, MCH, MCHC and anemia incidence rate of each group. Occurrence of adverse reaction were monitored at the same time. Results The hemoglobin levels of groupⅠ,ⅡandⅢwere higher than that of groupⅣ, and the incidence rates of groupⅠ,ⅡandⅢwere lower than that of the groupⅣ. The differences were statistically significant (P0.05);there were no statistically significant differences between the hemoglobin levels and anemia incidence rates of groupⅠand groupⅡ(P>0.05);GroupⅠshowed most adverse reactions. Conclusion It would be better to start iron sup-plementation at the age of 4 weeks so as to prevent iron deficiency anemia in mild low birth weight infants. Earlier iron supplementation will increase the incidence of adverse reaction, while later iron supplementation will increase the incidence of anemia.%目的:观察不同时期开始补铁以预防轻度低出生体重儿缺铁性贫血的疗效及不良反应发生情况,为预防低出生体重儿缺铁性贫血提供参考。方法将207例轻度低出生体重儿按家长知情同意原则分为三个实验组(Ⅰ组从2周龄

  4. Clinical characteristics of 207 measles cases with etiological diagnosis%经病原学确诊的207例儿童麻疹临床特征分析

    Institute of Scientific and Technical Information of China (English)

    黄辉; 邓莉; 郑崇光; 邓洁; 陈冬梅; 钱渊

    2012-01-01

    Objectives To understand the influence of measles vaccination on clinical manifestations of measles in children, different characteristics of measles in infants and children in order to improve early diagnosis of measles by analyzing the characteristics of measles cases with laboratory confirmed etiological data. Methods Clinical data were collected from children who visited the Department of Outpatient Infectious Diseases and hospitalized with clinical diagnosis of measles and confirmed by measles specific IgM and measles virus N gene fragment from January 2002 to December 2010. Measles specific IgM antibodies were tested using serum samples with ELISA. Measles virus N gene fragment was amplified from specimens of throat swabs and fresh urine by reverse transcription-polymerase chain reaction ( RT-PCR ). Analyses were performed in vaccinated and unvaccinated cased separately. Results ① In total, 207 cases of measles in children with etiological diagnosis were analyzed, including 123 males and 84 females, 53 vaccinated and 154 unvaccinated. Age distribution ranged from 0 to 15 years, including 69 cases ( 33. 3% ) of younger than 8 months ( who had not reached the age for primary measles vaccination ), and 45 cases ( 21. 7% ) of younger than 1 year of age. ②Cases with Beijing local residency was more common in vaccinated group than that in unvaccinated group. The peak incidence was found in April for all cases in two groups. 15.4% ( 24/154 ) cases with known exposure history in measles unvaccinated group and in unvaccinated group and 16. 9% ( 9/53 ) in measles vaccinated group, with no significant difference between two groups. ③The proportions of measles with symptoms of mucosa spots ( Koplik spots ) and cough were significantly lower in vaccinated group than in unvaccinated group while the other symptoms had no significant difference betweentwo groups. ④ Of 154 unvaccinated cases, 97 were younger than 1 and 57 older than 1 year old. Symptoms of eyes was

  5. Epidermoid carcinomas of the floor of mouth treated by exclusive irradiation: statistical study of a series of 207 cases

    International Nuclear Information System (INIS)

    Purpose. Our aim was to study the results and the complications of this series of 207 patients treated from 1976 to 1992 and to compare them with the results of the literature. Material and methods. The treatment consisted of a combination of external beam irradiation (EBI) (to the tumor and the node areas) and complementary brachytherapy to the primary tumor in 105 cases. In 102 cases, brachytherapy only was delivered to the tumor with or without neck dissection of the node areas. The brachytherapy was performed mostly with the hairpin technique in the beginning (in 61 cases) and subsequently the plastic tube technique with iridium wires. The dosimetry followed the Paris system rules. There were 41% T1, 48% T2, 8% T3, 2% T4 and 1% Tx with 83% N0, 12% N1, 3% N2, 2% N3. Ninety-one percent of patients were male and 9% were female. Results. The local control at 5 years is 97, 72 and 51%, respectively, for T1, T2, T3. The specific survival (without the patients dead of intercurrent disease or second cancer) was 88, 47 and 36%, and the overall survival at 5 years was 71, 42 and 35%. Of note, approximately one third of patients died of intercurrent disease or second cancers (70 patients = 34%). Significant factors that can influence the results are: for local control, the size of the lesion T1/T2/T3 (p < 0.0001); for the locoregional control, the absence of node involvement. The following factors are not significant: age and sex (age significant for survival). The significant treatment factors are the safety margin (p < 0.0003), brachytherapy only on T for T2N0 (p = 0.01). A total duration of treatment of less than 50 days is also significant. The spacing and the total dose (higher dose for large tumors) were not found to be significant. The complications were classified into four grades: grade 1, 17% (median healing, 2 months for soft tissue complications and 5 months for bone complications); grade 2, 12%; grade 3, 6% (frequently requiring surgical resection); grade 4

  6. Completion Report for Well ER-20-7: Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Restoration

    2010-04-28

    Well ER-20-7 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. The well was drilled in June 2009 as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to further investigate migration of radionuclides from the nearby, up-gradient TYBO and BENHAM underground nuclear tests, which originally was discovered at Well Cluster ER-20-5. This well also provided detailed hydrogeologic information in the Tertiary volcanic section that will reduce uncertainties within the Pahute Mesa-Oasis Valley hydrostratigraphic framework model. The main 44.45-centimeter hole was drilled to a depth of 681.8 meters and cased with 33.97-centimeter casing to 671.7 meters. The hole diameter was then decreased to 31.12 centimeters, and the well was drilled to total depth of 894.9 meters. The completion string, set to the depth of 890.0 meters, consists of 14.13-centimeter stainless-steel casing hanging from 19.37-centimeter carbon-steel casing. The 14.13-centimeter stainless-steel casing has one continuous slotted interval open to the Topopah Spring aquifer. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 meters, sidewall core samples from 20 depth intervals, various geophysical logs, water quality (primarily tritium) measurements, and water level measurements. The well penetrated 894.9 meters of Tertiary volcanic rock, including two saturated welded-tuff aquifers. A fluid level measurement was obtained during open-hole geophysical well logging for the upper, Tiva Canyon, aquifer at the depth of 615.7 meters on June 19, 2009. The fluid level measured in the open hole on June 27, 2009,after the total depth was reached and the upper aquifer was cased off, was also at the depth of 615.7 meters. Preliminary field measurements indicated 1

  7. Status of the NEXT Ion Thruster Long-Duration Test After 10,100 hr and 207 kg Demonstrated

    Science.gov (United States)

    Herman, Daniel A.; Soulas, George C.; Patterson, Michael J.

    2008-01-01

    The NASA s Evolutionary Xenon Thruster (NEXT) program is developing the next-generation ion propulsion system with significant enhancements beyond the state-of-the-art in ion propulsion to provide future NASA science missions with enhanced mission capabilities at a low total development cost. As part of a comprehensive thruster service life assessment utilizing both testing and analyses, a Long-Duration Test (LDT) was initiated to validate and qualify the NEXT propellant throughput capability to a qualification-level of 450 kg, 1.5 times the mission-derived throughput requirement of 300 kg. This wear test is being conducted with a modified, flight-representative NEXT engineering model ion thruster, designated EM3. As of June 21, 2007, the thruster has accumulated 10,100 hr of operation at the thruster full-input-power of 6.9 kW with 3.52 A beam current and 1800 V beam power supply voltage. The thruster has processed 207 kg of xenon and demonstrated a total impulse of 8.5 106 N-s; the highest total impulse ever demonstrated by an ion thruster in the history of space propulsion. Thruster performance tests are conducted periodically over the entire NEXT throttle table with input power ranging 0.5 to 6.9 kW. Overall ion thruster performance parameters including thrust, input power, specific impulse, and thruster efficiency have been nominal with little variation to date. Lifetime-limiting component erosion rates have been consistent with the NEXT service life assessment, which predicts the earliest failure sometime after 750 kg of xenon propellant throughput; well beyond the mission-derived lifetime requirement. The NEXT wear test data confirm that the erosion of the discharge keeper orifice, enlarging of nominal-current-density accelerator grid aperture cusps, and the decrease in cold grid-gap observed during the NSTAR Extended Life Test have been mitigated. This paper presents the status of the NEXT LDT to date.

  8. Investigation of the wave functions of low-lying states in 208Pb by the elastic and inelastic scattering of polarized protons from 207Pb

    International Nuclear Information System (INIS)

    The excitation functions of the differential cross section and the analyzing power of the scattering 207Pb(anti p, p') were measured in an energy range from 13.5 to 18 MeV at THETAlab = 1400 and 1600. By analyzing the elastic scattering 38 of in this range appearing isobar analog resonances (IAR) in 208 Bi were identified and their spins determined. The partly hypothetical spin relations out of literature for the states in the parent nucleus 208Pb had to be corrected in many cases. (orig.)

  9. Flame Atomic Absorption Spectrometric Determination of Gold After Solid-Phase Extraction of Its 2-Aminobenzothiazole Complex on Diaion SP-207.

    Science.gov (United States)

    Unsal, Yunus Emre; Tuzen, Mustafa; Soylak, Mustafa

    2016-03-01

    An SPE of Au (III) on a 2-aminobenzothiazole-coated Diaion SP 207-column system has been developed. The parameters, including pH of solution, amount of 2-aminobenzothiazole, eluent type, sample volume, and flow rates, were examined. The effects of alkali, alkali earth, and some metals were also studied. The recovery values at optimal conditions and detection limits for Au (III) were found as >95% and 3.8 μg L(-1), respectively. The factor of preconcentration was 250. The RSD value was determination of gold was applied to water, mine, soil, and anodic slime samples. PMID:26964845

  10. Optimization of Fermentation Conditions and Properties of an Exopolysaccharide from Klebsiella sp. H-207 and Application in Adsorption of Hexavalent Chromium

    OpenAIRE

    Li Qiang; Li Yumei; Han Sheng; Liu Yingzi; Song Dongxue; Hao Dake; Wang Jiajia; Qu Yanhong; Zheng Yuxia

    2013-01-01

    The novel exopolysaccharide HZ-7 is produced by Klebsiella sp. H-207, and its fermentation conditions were optimized by response surface methodology (RSM). In this study, the optimized medium consisted of sucrose 31.93 g/L, KNO(3) 2.17 g/L and K(2)HPO(4) 5.47 g/L; while the optimized culture conditions consisted of seed age 13 h, with an inoculum size of 10.6% and incubation temperature of 28.9°C. A maximum HZ-7 yield of about 15.05 g/L was achieved under the optimized conditions using RSM an...

  11. Randomized Pilot Trial of Eight Weeks of Bedaquiline (TMC207) Treatment for Multidrug-Resistant Tuberculosis: Long-Term Outcome, Tolerability, and Effect on Emergence of Drug Resistance

    OpenAIRE

    Diacon, A. H.; Donald, P R; Pym, A.; Grobusch, M.; Patientia, R. F.; Mahanyele, R.; Bantubani, N.; Narasimooloo, R.; De Marez, T.; van Heeswijk, R.; Lounis, N; Meyvisch, P.; Andries, K; McNeeley, D. F.

    2012-01-01

    The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with multidrug-resistant pulmonary tuberculosis treated with either the new diarylquinoline TMC207, recently renamed bedaquiline, or placebo, added to the first 8 weeks of a background regimen, are presented. Bedaquiline significantly reduced the time to culture conversion over 24 weeks (hazard ratio, 2.253; 95% confidence interval, 1.08 to 4.71; P = 0.031). With the exception of nausea reported in 26% of pa...

  12. Spectroscopic study of 206,207,208Pb isotopes by high resolution analysis of 24.5 MeV proton scattering

    International Nuclear Information System (INIS)

    206,207,208pb have been studied by 24.5 MeV proton inelastic scattering with a resolution of 20 keV. The angular distributions of the differential cross-sections corresponding to the different excited levels have been measured in a large angular region and analysed with the DWBA.This work shows that it exists between 4 and 5 MeV of excitation energy some strongly excited levels corresponding to transfer momenta l = 2, 4, 6 and 8. The single particle-hole models do not explain these states; so it will probably be necessary to introduce some several particle - hole configurations. (author)

  13. Radical Rearrangement Catalysis in an Enzyme at 190-207 K: Mechanistic Features Revealed by Substrate ^1H/^2H Isotope Effects

    Science.gov (United States)

    Zhu, Chen; Warncke, Kurt

    2009-11-01

    The decay kinetics of both the natural abundance and [1,1,2,2-^2H4]-aminoethanol generated Co^II-substrate radical pair catalytic intermediate in ethanolamine ammonia-lyase (EAL) from Salmonella typhimrium have been measured by using time-resolved, full-spectrum X-band continuous-wave electron paramagnetic resonance (EPR) spectroscopy in frozen aqueous solution from 190 to 207 K. The decay reaction proceeds through sequential radical covalent rearrangement and hydrogen atom transfer (HT) steps. In the temperature range from 190 to 207 K, the decay is biexponential, and the two phases correspond to distinct populations [1]. The ^1H/^2H isotope effects (IE) on the fast phase and slow phase are 1.3 and 0.8, respectively. These IE are not caused by a primary kinetic IE. Therefore, HT is rapid, relative to rearrangement. We propose that the fast phase is rate-determined by the rearrangement step, and that the slow phase is rate-determined by a step after rearrangement that is associated with protein guidance of the reactions. The results reveal microscopic features of the core reaction chemistry and protein dynamics participation in the reaction, which are not accessible at ambient temperatures.[4pt] [1] Zhu, C., Warncke, K. Biophys. J. 95, 5890 (2008). Supported by grant DK54514 from NIDDK/NIH.

  14. Optimization of fermentation conditions and properties of an exopolysaccharide from Klebsiella sp. H-207 and application in adsorption of hexavalent chromium.

    Directory of Open Access Journals (Sweden)

    Li Qiang

    Full Text Available The novel exopolysaccharide HZ-7 is produced by Klebsiella sp. H-207, and its fermentation conditions were optimized by response surface methodology (RSM. In this study, the optimized medium consisted of sucrose 31.93 g/L, KNO(3 2.17 g/L and K(2HPO(4 5.47 g/L; while the optimized culture conditions consisted of seed age 13 h, with an inoculum size of 10.6% and incubation temperature of 28.9°C. A maximum HZ-7 yield of about 15.05 g/L was achieved under the optimized conditions using RSM and single-factor experiments. Next the exopolysaccharide HZ-7 was partially purified and characterized. The resulting product showed good properties, such as high concentration of uronic acid (41.67%, low average molecular weight (about 1.94×10(5 Da and porous surface structure, were very advantageous to biosorption. Therefore HZ-7 was applied to absorb hexavalent chromium (Cr(VI. The maximum adsorption efficiency (99.2% which was obtained at an initial pH of 1.0 along with an initial Cr(VI concentration of 20 mg/L, was not affected by ordinary metal ions and temperature. These data suggest Klebsiella sp. H-207 exopolysaccharide will be promising potential for industrial application.

  15. Characterization of the ground X1 state of 204Pb19F, 206Pb19F, 207Pb19F, and 208Pb19F

    International Nuclear Information System (INIS)

    Pure rotational spectra of the ground electronic-vibrational X1 state of 204Pb19F, 206Pb19F, 207Pb19F, and 208Pb19F are measured with a resonator pulsed supersonic jet Fourier-transform microwave spectrometer. Also reported is a new measurement of the Stark effect on the optical spectra of A(leftarrow)X1 transitions. These spectra are combined with published high-resolution infrared spectra of X2↔X1 transitions in order to create a complete picture of the ground state of lead monofluoride. For the microwave data, molecules are prepared by laser ablation of lead target rods and stabilized in a supersonic jet of neon mixed with sulfur hexafluoride. For the optical Stark spectra, a continuous source of molecules is created in a nozzle heated to 1000 deg. C. The microwave spectra confirm, improve, and extend previously reported constants that describe the rotational, spin-orbit, and hyperfine interactions of the ground electronic state of the PbF molecule. A discrepancy concerning the sign of the hyperfine constant describing the 207Pb nucleus is discussed. Magnetic-field-dependent microwave spectra are used to characterize the Zeeman interaction in terms of two g factors of the body-fixed electronic wave function. The optical Stark spectra are used to characterize the electric dipole moment of the X1 and A states.

  16. Developments of 207Pb, 208Pb and 209Bi target wheels in the synthesis of 107Ns, 108Hs and 109Mt

    International Nuclear Information System (INIS)

    The developments of 207Pb, 208Pb and 209Bi target wheels and their applications in heavy-ion fusion reactions are reviewed. In both, fabrication and use, the centers of the evaporator or accelerator beams are focussed at wheel radii of 155 mm to specially shaped frames which generate very homogeneous target layers and very constant reaction and counting rates in the experiment. Target areas of up to ∼98% of a wheel's circumference of 974 mm can be provided. The preparation procedures for necessary C backings and protecting layers of C are described, and details are given for the developments of high-vacuum evaporations of 207Pb, 208Pb and 209Bi with deposition yields of 35-55% from tantalum crucibles. The applications of the target wheels in heavy-ion fusion reactions with beams of 54Cr and 58Fe at energies near the Coulomb barrier and intensities of ∼1012 particles/s are mentioned. The target parameters for the production runs of the new chemical elements 107Ns, 108Hs and 109Mt are included. (orig.)

  17. Process for producing astatine-211 for radiopharmaceutical use

    International Nuclear Information System (INIS)

    A one-step chemical manipulation is described in combination with a distillation and collection process for producing At-211 comprising; a. providing a target of irradiated Bismuth coated to a predetermined thickness of a backing member, b. providing a vapor-producing still operably connected with a condenser that has a water cooled condensate collector formed of a dry silica gel mesh maintained at a temperature above the freezing point of water, and providing an effluent gas filter that is operably connected to receive effluent gas from the condenser, c. heating the target in the still at a temperature in the range of about 6300-6800C for a time period in the range of 50 to 80 minutes, to evole At-211 vapor from the target, c. providing a dry carrier gas having an oxygen concentration that is sufficient to form Bi/sub 2/O/sub 3/ thereby to essentially preclude vaporization of Bi metal, passing the carrier gas through the still to carry the At-211 vapor to the condenser, and to carry effluent from the condenser to the effluent gas filter, e. eluting At-211 from the condensate collector of the condenser with a controlled volume of eluent containing predetermined solvents that are compatible with a given desired radiopharmaceutical procedure, and f. collecting the At-211 in the controlled volume of eluent for use in the given radiopharmaceutical procedure

  18. Uptake of 207Pb and 111Cd through bark of mature sugar maple, white ash and white pine: a field experiment

    International Nuclear Information System (INIS)

    Cd and Pb uptake by bark is not likely to be a major contribution to metal burdens in tree xylem. - A field study was undertaken to determine whether 207Pb and 111Cd, applied to the exterior bark of sugar maple (Acer saccharum Marsh.), white ash (Fraxinus americana L.) and white pine (Pinus strobus L.), could enter xylem tissue. Stable isotope tracers (3 μg Pb ml-1; 2 μg Cd ml-1) were applied separately to bark in simulated rainfall, acidified to pH 4.5, in multiple doses over a 4 month (July-October) period. Tree cores were extracted from the region of application in the following March, and Pb and Cd isotopes were measured in bark and the outer tree rings using inductively coupled plasma mass spectrometry. The majority of the applied stable isotope tracer recovered (over 94%) was present in bark tissue, although a small amount of each metal tracer entered the outer (1-3) tree rings in all trees. Despite high concentrations of excess 207Pb in bark (up to 50 μg g-1), the maximum concentration of excess 207Pb measured in tree rings was only around 50 ng g-1, which represents less than 30% of the background Pb concentration in wood at the study site. High excess 111Cd concentrations in bark (up to 35 μg g-1) also resulted in small increases in 111Cd in wood (up to 50 ng g-1), but due to lower background Cd concentrations in wood, such increases more than doubled the amount of Cd in wood compared with background levels. However, at sites where such high bark Cd concentrations are found, uptake from Cd-contaminated soil would probably be much greater than found at our study site. It appears that Cd and Pb applied to bark can enter woody tissue, but that this route of uptake is likely to be a minor contributor to the metal burden in wood

  19. Chemical-shift tensors of heavy nuclei in network solids: a DFT/ZORA investigation of (207)Pb chemical-shift tensors using the bond-valence method.

    Science.gov (United States)

    Alkan, Fahri; Dybowski, C

    2015-10-14

    Cluster models are used in calculation of (207)Pb NMR magnetic-shielding parameters of α-PbO, β-PbO, Pb3O4, Pb2SnO4, PbF2, PbCl2, PbBr2, PbClOH, PbBrOH, PbIOH, PbSiO3, and Pb3(PO4)2. We examine the effects of cluster size, method of termination of the cluster, charge on the cluster, introduction of exact exchange, and relativistic effects on calculation of magnetic-shielding tensors with density functional theory. Proper termination of the cluster for a network solid, including approximations such as compensation of charge by the bond-valence (BV) method, is essential to provide results that agree with experiment. The inclusion of relativistic effects at the spin-orbit level for such heavy nuclei is an essential factor in achieving agreement with experiment. PMID:26345261

  20. An investigation of cooling flows and general cluster properties from an X-ray image deprojection analysis of 207 clusters of galaxies

    CERN Document Server

    White, D A; Forman, W R

    1997-01-01

    We present an X-ray image deprojection analysis of Einstein Observatory imaging data on 207, clusters of galaxies. The resulting radial profiles for luminosity, temperature, and electron density variations are determined from the cluster surface-brightness profiles according to gravitational potential constraints from average Tx and Vopt observations. This enables us to determine cooling-flow and other cluster properties, such as baryon fractions, S-Z microwave decrements, and Thomson depths. We have compiled a catalogue of the detected cooling flows, and investigated their effects on general cluster properties. Self-consistent correlations between the cluster X-ray luminosity, temperature, and optical velocity-dispersion, are determined accounting for errors in both dimensions of the data. These fits indicate that the temperatures of clusters are isothermal and that they have spectral beta-values consistent with unity. We find that the X-ray Lx, Tx, and optical Vopt relations depend significantly on the cool...

  1. A new organic metal with mixed anion: β-(ET)2(IBr2)0.7(I3)0.3. Synthesis, structure, properties

    International Nuclear Information System (INIS)

    Crystals β-(ET)2(IBr2)0.7(I3)0.3 (1) were prepared by oxidation of bis(ethylenedithio)tetrathiafulvalene (ET) by solution of IBr in nitrobenzene at 100 deg C with subsequent slow cooling of the reactive mixture. Compound 1 was studied by the methods of X-ray diffraction analysis at 293 and 130 K, differential scanning calorimetry in the range of 115-463 K and conductometry in the range of 0-300 K. It was ascertained that the compound prepared in terms of its structure and character of conductivity anisotropy variation in the range of 100-300 K is similar to β-(ET)2IBr2. At 135 K the order-disorder type phase transition is observed for compound 1, its enthalpy being equal to 3.3 J/mg

  2. Performance Analysis of Wavelet Channel Coding in COST207-based Channel Models on Simulated Radio-over-Fiber Systems at the W-Band

    DEFF Research Database (Denmark)

    Cavalcante, Lucas Costa Pereira; Silveira, Luiz F. Q.; Rommel, Simon;

    2016-01-01

    challenge in systems operating in the millimeter wave regime. This work takes the WCC one step beyond by performance evaluation in terms of bit error probability, over time-varying, frequency-selective multipath Rayleigh fading channels. The adopted propagation model follows the COST207 norm, the main......, such systems use diversity schemes in combination with digital signal processing (DSP) techniques to overcome effects such as fading and inter-symbol interference (ISI). Wavelet Channel Coding (WCC) has emerged as a technique to minimize the fading effects of wireless channels, which is a mayor...... international standard reference for GSM, UMTS, and EDGE applications. The results show how WCC can be efficient against ISI. To the best of our knowledge this is the first time WCC is considered on Radio-over-Fiber transmissions at mm-wave range....

  3. Source identification of Pb in aerosols at Jeju-do, Korea by using 207Pb/206Pb and 208Pb/206Pb

    International Nuclear Information System (INIS)

    Aerosols and source related materials (fly ash from refuse incinerators, vehicle exhaust and soil) were collected in April, 2002 in the northern areas of Jeju-do, Korea, and the Pb isotopic ratios (207Pb/206Pb and 208Pb/206Pb) of the samples were measured in order to estimate the Pb sources of the aerosols. The Pb isotopic ratios of the aerosols were classified into two groups, depending on the sampling date. One group showed similar Pb isotopic ratios with those of the source related materials, suggesting that the contribution of the regional sources to the aerosols was very large. The other showed different Pb isotopic ratios from those of the regional sources and relatively high Pb isotopic ratios compared to the ratios of the first group. The results suggest that in the continental Asia there seems to be a long range transport of Pb with high ratios in desert sands, which are carried by northwest seasonal winds.(author)

  4. Excitation functions of residual nuclei production from 40–2600 MeV proton-irradiated 206,207,208,natPb and 209Bi

    Indian Academy of Sciences (India)

    Yu E Titarenko; V F Batyaev; V M Zhivun; V O Kudryashov; K A Lipatov; A V Ignatyuk; S G Mashnik

    2007-02-01

    The work is aimed at experimental determination of the independent and cumulative yields of radioactive residual nuclei produced in intermediate-energy proton-irradiated thin targets made of highly isotopic enriched and natural lead (206,207,208,natPb) and 209Bi. 5972 radioactive product nuclide yields have been measured in 55 thin targets induced by 0.04, 0.07, 0.10, 0.15, 0.25, 0.6, 0.8, 1.2, 1.4, 1.6 and 2.6 GeV protons extracted from the ITEP U-10 proton synchrotron. The measured data have been compared with data obtained at other laboratories as well as with theoretical simulations by seven codes. We found that the predictive power of the tested codes is different but is satisfactory for most of the nuclides in the spallation region, though none of the codes agree well with the data in the whole mass region of product nuclides and all should be improved further.

  5. Pahute Mesa Well Development and Testing Analyses for Wells ER-20-7, ER-20-8 #2, and ER-EC-11, Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Greg Ruskauff

    2011-12-01

    This report analyzes the following data collected from ER-20-7, ER-20-8 No.2, and ER-EC-11 during WDT operations: (1) Chemical indicators of well development (Section 2.0); (2) Static hydraulic head (Section 3.0); (3) Radiochemistry and geochemistry (Section 4.0); (4) Drawdown observed at locations distal to the pumping well (Section 5.0); and (5) Drilling water production, flow logs, and temperature logs (Section 6.0). The new data are further considered with respect to existing data as to how they enhance or change interpretations of groundwater flow and transport, and an interim small-scale conceptual model is also developed and compared to Phase I concepts. The purpose of well development is to remove drilling fluids and drilling-associated fines from the formation adjacent to a well so samples reflecting ambient groundwater water quality can be collected, and to restore hydraulic properties near the well bore. Drilling fluids can contaminate environmental samples from the well, resulting in nonrepresentative measurements. Both drilling fluids and preexisting fines in the formation adjacent to the well can impede the flow of water from the formation to the well, creating artifacts in hydraulic response data measured in the well.

  6. Reproducibility of Retinol Binding Protein 4 and Omentin-1 Measurements over a Four Months Period: A Reliability Study in a Cohort of 207 Apparently Healthy Participants.

    Directory of Open Access Journals (Sweden)

    Clemens Wittenbecher

    Full Text Available The reliability of single time point measurements of the novel adipokines retinol-binding protein 4 and omentin-1 in the blood has not been evaluated in large samples yet. The present study aimed to assess the amount of biological variation of these two adipokines within individuals. The study sample comprised 207 participants (124 women and 83 men from Potsdam (Germany and surrounding areas, with an average age of 56.5 years (SD 4.2. Blood samples were collected from each participant twice, approximately four months apart. Using enzyme linked immunosorbent assays, the concentrations of retinol-binding protein 4 and omentin-1 were determined in EDTA plasma. As indicators of reliability, intraclass correlation coefficients (ICCs were calculated from the repeated biomarker measurements. The ICCs for repeated retinol-binding protein 4 and omentin-1 measurements were 0.77 (95% CI 0.71, 0.82 and 0.83 (95% CI 0.78, 0.87, respectively, indicating for both adipokines excellent reliability. ICCs were stable across strata according to sex, age, BMI, and blood pressure. Thus, for epidemiological studies it seems reasonable to rely on concentrations of retinol-binding protein 4 and omentin-1 in samples from a single time point if repeated measurements are not available.

  7. UGT2B17 genotype and the pharmacokinetic serum profile of Testosterone during substitution therapy with Testosterone Undecanoate. A retrospective experience from 207 men with hypogonadism.

    Directory of Open Access Journals (Sweden)

    Anne Kirstine eBang

    2013-07-01

    Full Text Available BackgroundTestosterone (T is mainly excreted in the urine as testosterone glucuronide (TG. This glucuronidation is partly dependent on the UGT2B17 genotype, and TG excretion is therefore lower in men having the UGT2B17 deletion. However, the possible influence of UGT2B17 genotype on serum T during androgen therapy is unknown. We retrospectively investigated the possible association between the UGT2B17 gene polymorphism and serum T levels in hypogonadal men during Testosterone undecanoate (TU substitution therapy.Subjects and methods207 patients treated with TU (Nebido® were genotyped by qPCR for the UGT2B17 deletion polymorphism. All were given 1000 mg TU per injection at 0, 6 and 18 weeks. Blood samples were taken 2 and 6 weeks after the 1st and 2nd injection, prior to the 3rd injection, and after 2-3 years of treatment. We analysed for the levels of T, luteinizing hormone, sex-hormone-binding globulin, estradiol, prostate specific antigen, haematocrit, haemoglobin and total cholesterol. ResultsThe UGT2B17 genotype frequency was: ins/ins: 42%, ins/del: 44% and del/del: 14%. During the initial 18 weeks of TU treatment, large intra- and inter-individual variations in serum T levels were observed. Large peaks in T levels, ranging from 6.7 nmol/l to 69.5 nmol/l, were noted 2 weeks after injections, regardless of the genotype. T levels did not differ between the 3 genotypes prior to the 3rd injection, but the del/del group had significantly lower levels of LH. At follow-up after 2-3 years, the injection interval or daily T dosage was not dependent on the UGT2B17 genotype. ConclusionIn conclusion, we found large intra- and inter-individual variations in serum T during standard TU treatment regimen in hypogonadal men. Only subtle differences in serum T and LH were noted according to UGT2B17 genotype, which however suggest that the UGT2B17 genotype exert modest influence on the pharmacokinetic profile of T after TU treatment.

  8. The impact of langerin (CD207)+ dendritic cells and FOXP3+ Treg cells in the small bowel mucosa of children with celiac disease and atopic dermatitis in comparison to children with functional gastrointestinal disorders.

    Science.gov (United States)

    Vorobjova, Tamara; Ress, Krista; Luts, Katrin; Uibo, Oivi; Uibo, Raivo

    2016-08-01

    In the present study we aimed to evaluate the impact of langerin (CD207)+ dendritic cells (DCs) and FOXP3+ Treg cells in the intestinal mucosa of children with celiac disease (CD) and atopic dermatitis (AD) in comparison to children with functional gastrointestinal disorders (FGD). Seventy-five children (37 male, mean age 8.4 ± 4.8 years), who randomly underwent small bowel biopsy, were studied. The CD was diagnosed in 14 children, including five persons with concomitant AD (all positive for anti-tissue transglutaminase IgA antibodies and with small bowel atrophy). Normal small bowel mucosa was found in eight patients with AD and in 53 patients with FGD. The sera of all patients were tested for total and specific IgE antibodies to food allergen panels. Staining for CD11c+, langerin (CD207+) DCs, CD4+, and FOXP3+ Treg cells was performed on paraffin-embedded sections of bioptates using immunohistochemistry. The density of CD11c+ DCs, CD4+, and FOXP3+ Treg cells was higher in the CD patients compared to the AD and FGD patients (p = 0.02; p = 0.001). In AD, significantly higher density of CD11c+ DCs was detected in patients positive for specific IgE to food allergen panels (p = 0.02). The FGD patients with elevated total IgE had increased density of langerin (CD207)+ DCs compared to the patients with normal total IgE levels (p = 0.01). The increased density of FOXP3+ Treg cells, CD4+, cells and CD11c+ DCs was associated with CD but not with AD. The elevated level of total IgE or specific IgE to food allergens was associated with more pronounced expression of DCs, indicating a possible link between the presence of these cells in small bowel mucosa with elevated level of serum IgE. PMID:27200487

  9. In vitro anticancer activity of Betulinic acid and derivatives thereof on equine melanoma cell lines from grey horses and in vivo safety assessment of the compound NVX-207 in two horses.

    Science.gov (United States)

    Liebscher, G; Vanchangiri, K; Mueller, Th; Feige, K; Cavalleri, J-M V; Paschke, R

    2016-02-25

    Betulinic acid, a pentacyclic triterpene, and its derivatives are promising compounds for cancer treatment in humans. Melanoma is not only a problem for humans but also for grey horses as they have a high potential of developing melanoma lesions coupled to the mutation causing their phenotype. Current chemotherapeutic treatment carries the risk of adverse health effects for the horse owner or the treating veterinarian by exposure to antineoplastic compounds. Most treatments have low prospects for systemic tumor regression. Thus, a new therapy is needed. In this in vitro study, Betulinic acid and its two derivatives B10 and NVX-207, both with an improved water solubility compared to Betulinic acid, were tested on two equine melanoma cell lines (MelDuWi and MellJess/HoMelZh) and human melanoma (A375) cell line. We could demonstrate that all three compounds especially NVX-207 show high cytotoxicity on both equine melanoma cell lines. The treatment with these compounds lead to externalization of phosphatidylserines on the cell membrane (AnnexinV-staining), DNA-fragmentation (cell cycle analysis) and activation of initiator and effector caspases (Caspase assays). Our results indicate that the apoptosis is induced in the equine melanoma cells by all three compounds. Furthermore, we succeed in encapsulating the most active compound NVX-207 in 2-Hydroxyprolyl-β-cyclodextrine without a loss of its activity. This formulation can be used as a promising antitumor agent for treating grey horse melanoma. In a first tolerability evaluation in vivo the formulation was administered every one week for 19 consecutive weeks and well tolerated in two adult melanoma affected horses. PMID:26772157

  10. Measurements of Neutron-Induced Fission Cross Sections of 205Tl, 204, 206, 207, 208Pb, and 209Bi using Quasi-Monoenergetic Neutrons in the Energy Range 35 - 174 MeV

    Science.gov (United States)

    Tutin, Gennady A.; Ryzhov, Igor V.; Eismont, Vilen P.; Mitryukhin, Andrey G.; Oplavin, Valery S.; Soloviev, Sergey M.; Blomgren, Jan; Condè, Henri; Olsson, Nils; Renberg, Per-Ulf

    2005-05-01

    Cross sections for neutron-induced fission of 205Tl, 204, 206, 207, 208Pb, and 209Bi were measured in the energy range from 35 MeV to 174 MeV. The experiments were done at the neutron beam facility of The Svedberg Laboratory, using a multi-section Frisch-gridded ionization chamber for detection of the fission fragments. The neutron-induced fission cross section of 238U was employed as a reference. The results of the measurements are compared with existing experimental data.

  11. Measurements of neutron-induced fission cross-sections of 205Tl, 204,206,207,208Pb and 209Bi with a multi-section Frisch-gridded ionization chamber

    Science.gov (United States)

    Ryzhov, I. V.; Tutin, G. A.; Mitryukhin, A. G.; Oplavin, V. S.; Soloviev, S. M.; Blomgren, J.; Renberg, P.-U.; Meulders, J. P.; El Masri, Y.; Keutgen, Th.; Prieels, R.; Nolte, R.

    2006-06-01

    Neutron-induced fission cross-sections of 205Tl, 204,206,207,208Pb and 209Bi have been measured in the energy range from 30 to 180 MeV. The measurements were performed with quasi-monoenergetic neutron beams using a multi-section Frisch-gridded ionization chamber. The neutron-induced fission cross-sections of 238U were used as reference data. The experimental techniques are described in detail as well as the data processing. The results are compared with existing experimental data.

  12. Measurements of neutron-induced fission cross-sections of 205Tl, 204,206,207,208Pb and 209Bi with a multi-section Frisch-gridded ionization chamber

    International Nuclear Information System (INIS)

    Neutron-induced fission cross-sections of 205Tl, 204,206,207,208Pb and 209Bi have been measured in the energy range from 30 to 180 MeV. The measurements were performed with quasi-monoenergetic neutron beams using a multi-section Frisch-gridded ionization chamber. The neutron-induced fission cross-sections of 238U were used as reference data. The experimental techniques are described in detail as well as the data processing. The results are compared with existing experimental data

  13. Production cross section of At radionuclides from $^{7}$Li+$^{\\textrm{nat}}$Pb and $^{9}$Be+$^{\\textrm{nat}}$Tl reactions

    CERN Document Server

    Maiti, Moumita

    2011-01-01

    Earlier we reported theoretical studies on the probable production of astatine radionuclides from $^{6,7}$Li and $^{9}$Be-induced reactions on natural lead and thalliun targets, respectively. For the first time, in this report, production of astatine radionuclides has been investigated experimentally with two heavy ion induced reactions: $^{9}$Be+$^{\\textrm{nat}}$Tl and $^{7}$Li+$^{\\textrm{nat}}$Pb. Formation cross sections of the evaporation residues, $^{207,208,209,210}$At, produced in (HI, xn) channel, have been measured by the stacked-foil technique followed by the off-line $\\gamma$-spectrometry at the low incident energies ($<$50 MeV). Measured excitation functions have been explained in terms of compound nuclear reaction mechanism using Weisskopf-Ewing and Hauser-Feshbach model. Absolute cross section values are lower than the respective theoretical predictions.

  14. Characterization of the ground X{sub 1} state of {sup 204}Pb{sup 19}F, {sup 206}Pb{sup 19}F, {sup 207}Pb{sup 19}F, and {sup 208}Pb{sup 19}F

    Energy Technology Data Exchange (ETDEWEB)

    Mawhorter, Richard J.; Murphy, Benjamin S.; Baum, Alexander L.; Sears, Trevor J.; Yang, T.; Rupasinghe, P. M; McRaven, C. P.; Shafer-Ray, N. E.; Alphei, Lukas D.; Grabow, Jens-Uwe [Department of Physics and Astronomy, Pomona College, Claremont, California 91711-6327 (United States); Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973-5000 (United States); Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, Norman, Oklahoma (United States); Gottfried-Wilhelm-Leibniz-Universitaet, Institut fuer Physikalische Chemie and Elektrochemie, Lehrgebiet A, D-30167 Hannover (Germany)

    2011-08-15

    Pure rotational spectra of the ground electronic-vibrational X{sub 1} state of {sup 204}Pb{sup 19}F, {sup 206}Pb{sup 19}F, {sup 207}Pb{sup 19}F, and {sup 208}Pb{sup 19}F are measured with a resonator pulsed supersonic jet Fourier-transform microwave spectrometer. Also reported is a new measurement of the Stark effect on the optical spectra of A(leftarrow)X{sub 1} transitions. These spectra are combined with published high-resolution infrared spectra of X{sub 2}{r_reversible}X{sub 1} transitions in order to create a complete picture of the ground state of lead monofluoride. For the microwave data, molecules are prepared by laser ablation of lead target rods and stabilized in a supersonic jet of neon mixed with sulfur hexafluoride. For the optical Stark spectra, a continuous source of molecules is created in a nozzle heated to 1000 deg. C. The microwave spectra confirm, improve, and extend previously reported constants that describe the rotational, spin-orbit, and hyperfine interactions of the ground electronic state of the PbF molecule. A discrepancy concerning the sign of the hyperfine constant describing the {sup 207}Pb nucleus is discussed. Magnetic-field-dependent microwave spectra are used to characterize the Zeeman interaction in terms of two g factors of the body-fixed electronic wave function. The optical Stark spectra are used to characterize the electric dipole moment of the X{sub 1} and A states.

  15. Stable (206Pb, 207Pb, 208Pb) and radioactive (210Pb) lead isotopes in 1 year of growth of Sphagnum moss from four ombrotrophic bogs in southern Germany: Geochemical significance and environmental implications

    Science.gov (United States)

    Shotyk, William; Kempter, Heike; Krachler, Michael; Zaccone, Claudio

    2015-08-01

    The surfaces of Sphagnum carpets were marked with plastic mesh and 1 year later the production of plant matter was harvested in four ombrotrophic bogs from two regions of southern Germany: Upper Bavaria (Oberbayern, OB) and the Northern Black Forest (Nordschwarzwald, NBF). Radioactive, 210Pb was determined in solid samples using ultralow background gamma spectrometry while total Pb concentrations and stable isotopes (206Pb, 207Pb, 208Pb) were determined in acid digests using ICP-SMS. Up to 12 samples (40 × 40 cm) were collected per site, and 6-10 sites investigated per bog. The greatest variations within a given sampling site were in the range 212-532 Bq kg-1 for 210Pb activity, whereas 206Pb/207Pb and 208Pb/206Pb varied less than 1%. The median values of all parameters for the sites (6-10 per bog) were not significantly different. The median activities of 210Pb (Bq kg-1) in the mosses collected from the bogs in NBF (HO = 372 ± 56, n = 55; WI = 342 ± 58, n = 93) were slightly less from those in OB (GS = 394 ± 50, n = 55; KL = 425 ± 58, n = 24). However, the mosses in the NBF bogs exhibited much greater productivity (187-202 g m-2 a-1) compared to those of OB (71-91 g m-2 a-1), and this has a profound impact on the accumulation rates of 210Pb (Bq m-2 a-1), with the bogs in the NBF yielding fluxes (HO = 73 ± 30; WI = 65 ± 20) which are twice those of OB (GS = 29 ± 11; KL = 40 ± 13). Using the air concentrations of 210Pb measured at Schauinsland (SIL) in the southern Black Forest and average annual precipitation, the atmospheric fluxes of 210Pb at SIL (340 Bq m-2 a-1) exceeds the corresponding values obtained from the mosses by a factor of five, providing the first quantitative estimate of the net retention efficiency of 210Pb by Sphagnum. When the 210Pb activities of all moss samples are combined (n = 227), a significant decrease with increasing plant production rate is observed; in contrast, total Pb concentrations show the opposite trend. The contrasting

  16. U/Pb (SHRIMP), 207Pb/206Pb, Rb/Sr, Sm/Nd e K/Ar geochronology of granite-greenstone terrains of Gaviao Block: implications for the Proterozoic and Archean evolution of Sao Francisco Craton, Brazil

    International Nuclear Information System (INIS)

    The Gaviao Block (GB) in the northern portion of the Sao Francisco Craton-Northeast of Brazil, constitutes one of the oldest Archean fragments of the South American Platform Archean crust. GB underwent several events of juvenile accretion and reworking of continental crust along its evolutionary history, notably between the Archean and the Paleoproterozoic. 207Pb/206Pb isotopic analyses were carried out in two zircons populations from strongly migmatized TTG terranes found in the proximity of Brumado: the first population (7 crystals) is taken as representative of the crystallization period of the TTG terranes at 3300 ± 45 Ma; the second (2 crystals) represents the age of the first even of metamorphism/migmatization at 2910 ± 10 Ma. 207 Pb/206 Pb analyses in zircons from an outcrop of non-migmatized TTG in the area yielded a 3202 ± 15 Ma age (4 crystals), interpreted to be the crystallization period of the gneiss protolith. Sm/Nd analyses on the TTG rocks of the Brumado region yielded TDM model ages varying between 3.26 and 3.36 Ga and εNd(t) between -3.5 and +0.7. These data suggest the occurrence of juvenile accretions to the continental crust during the Archean, with differential involvement of crustal materials. The geochemical data of rare earth elements corresponding to the TTG terranes revealed moderate LRRE contents (LaN=83,5), low HREE contents (LaN=2,5) and a fairly fractionated pattern (La/Yb)N=34, besides lack of negative Eu anomaly, showing that these rocks have similar compositions to those TTG terranes of cratonic continents, as well as some Archean rocks from CSF (e.g. Sete Voltas, Boa Vista). Finally, the youngest ages present in GB rocks (ca. 1.2-0.45 Ga) represent the role played by tectono thermal events, which produced partial or total rejuvenation of the Rb/Sr and K/Ar isotopic systems during the Espinhaco and Brasiliano cycles. In particular, K/Ar ages illustrate the effect of younger regional cooling episodes related to the Brasiliano

  17. Distribution Characteristics of Syndrome Types in TCM in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)%207例晚期非小细胞肺癌中医证型分布特点

    Institute of Scientific and Technical Information of China (English)

    杨小兵; 龙顺钦; 邓宏; 刘伟; 河文峰; 潘宗奇; 周宇姝; 蔡姣芝; 欧阳育树

    2013-01-01

    Objective: To investigate the distribution characteristics of TCM syndrome types in patients with advanced non-smallcell lung cancer ( NSCLC ) . Methods; Patients were selected with the inclusion criteria, retrospective method was used to observe the distribution. TCM syndromes were generalized according to pre-designed forms and diagnostic criteria for clinical syndromes, inputting the questionnaire data into database, the statistical analysis was conducted. Results : Total of 207 patients with advanced NSCLC ( stage Ⅲ B and Ⅳ ) were collected. The distribution of TCM syndromes were as follows: Qi-deficiency with damp-phlegm type was the most common type, accounted for 76.3%; Qi-yin deficiency type followed, accounted for 9.2%; Qi stagnation with blood stasis type, Yin asthenia and excess toxin and heat type and toxic heat flourishing type were 5.8%, 5.8% and 2.9%, respectively. Conclusion; The study suggests that Qi-deficiency with damp-phlegm type was the most common type in patients with advanced non-small cell lung cancer ( stage Ⅲ B and Ⅳ ) .%目的:探讨晚期(ⅢB及Ⅳ期)非小细胞肺癌的中医证型分布特点.方法:采用回顾性的研究方法,按照纳入标准筛选病例,根据预先设计的观察表和临床证型诊断标准,归纳证型,将调查表数据输入数据库,进行统计学分析.结果:共收集到207例晚期非小细胞肺癌患者,各证型构成如下:气虚痰湿型最多,占76.3%,其次为气阴两虚型,占9.2%,气滞血瘀型、阴虚毒热型及热毒炽盛型分别占5.8%、5.8%、2.9%.结论:晚期(ⅢB及Ⅳ期)非小细胞肺癌的中医证型以气虚痰湿型为主.

  18. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  19. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  20. Astatination of nanoparticles containing silver as possible carriers of 211At

    Czech Academy of Sciences Publication Activity Database

    Lebeda, Ondřej; Kučka, Jan; Hrubý, Martin; Koňák, Čestmír; Kozempel, Ján

    2006-01-01

    Roč. 64, - (2006), s. 201-206. ISSN 0969-8043 R&D Projects: GA AV ČR KJB4048302; GA AV ČR KJB4050408 Institutional research plan: CEZ:AV0Z1048901 Keywords : nanoparticles * 211AT * Atalpha particle therapy Subject RIV: CH - Nuclear ; Quantum Chemistry Impact factor: 0.924, year: 2006

  1. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  2. Rb-Sr and single - zircon grain 207Pb / 206Pb chronology of the Monesterio granodiorite and related migmatites. Evidence of a Late Cambrian melting event in the Ossa-Morena Zone, Iberian Massif

    Directory of Open Access Journals (Sweden)

    Bea, F.

    1999-04-01

    Full Text Available The Monesterio granodiorite, a small granodioritic body placed in a migmatitic complex in the SW of the Olivenza-Monesterio antiform, is a key plutonic body to understanding the relationships among the magmatism, metamorphism, and deformation in the Ossa-Morena Zone, SW Iberian Massif. We dated the granodiorite with the single zircon stepwise-evaporation 207Pb/206Pb method, and the related migmatization event with the Rb-Sr method on leucosomes. Our results indicate that the Monesterio granodiorite crystallised at 510 ± 7 Ma and its protolith had a component with Upper Proterozoic zircons with a minimum age of 1696 Ma. Leucosomes give a Rb-Sr age of 511 ± 40 Ma (MSWD =1,7 with initial 87Sr/86Sr =0.70914 ± 0.00048. The lower initial 87Sr/86Sr of the granodiorite and its calc-alkaline chemistry precludes it from having derived from the same protolith as the migmatites. The existence of different magmatic bodies in the Ossa-Morena Zone with ages clustering around 500-510 Ma reveals the existence of a significant melting event during the Late Cambrian that involved protoliths with very different geochemical and isotopic signatures.La granodiorita de Monesterio es un pequeño cuerpo emplazado en un complejo migmatítico en el SO del antiforme Olivenza-Monesterio, importante para entender las relaciones entre magmatismo, metamorfismo y deformación en la Zona de Ossa-Morena. Se ha datado la granodiorita por el método de evaporación secuencial de 207Pb/206Pb en cristal único de circón y los leucosomes de las migmatitas circundantes por el método Rb-Sr. Los datos indican una edad de cristalización de la granodiorita de 510 ± 4 Ma y un posible protolito Proterozoico Superior con una edad mínima de ∼1.700 Ma, obtenida a partir de núcleos heredados de los circones analizados. Los leucosomes dan una edad Rb-Sr de 511 ± 40 Ma, con una relación 87Sr/86Sr=0,70914 ± 0,00048. La relación inicial de 87Sr/86Sr en la granodiorita (

  3. 21 CFR 207.3 - Definitions.

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    2010-04-01

    ..., and animal facilities used for the production or control testing of licensed biologicals, and... definition of drugs in section 201(g) of the act. The term includes manipulation, sampling, testing, or... promotional claims used for the drug, e.g., if more than one medical journal advertisement is used but...

  4. 77 FR 207 - National Mentoring Month, 2012

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    2012-01-03

    ... States of America the two hundred and thirty- sixth. (Presidential Sig.) [FR Doc. 2011-33796 Filed 12-30... growing into adulthood. By setting a positive example and sharing their time, knowledge, and experience...- discipline, we make a powerful and lasting investment in our youth, our communities, and our Nation....

  5. 49 CFR 393.207 - Suspension systems.

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    2010-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS PARTS AND ACCESSORIES... nor shifted out of position. (d) Coil springs. No coil spring shall be cracked or broken. (e)...

  6. 12 CFR 207.7 - Annual reports.

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    2010-01-01

    ... expenses; (D) Entertainment expenses; (E) Payment of consulting and professional fees; and (F) Other... as the Internal Revenue Service Return of Organization Exempt From Income Tax on Form 990, or any other Internal Revenue Service form, state tax form, report to members or shareholders, audited...

  7. 15 CFR 970.207 - Antitrust information.

    Science.gov (United States)

    2010-01-01

    ... ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR EXPLORATION LICENSES Applications Contents § 970... license, provided that said agreement relates to deep seabed hard mineral resource exploration or mining... purchase or sale in or to, the United States of copper, nickel, cobalt or manganese minerals or any...

  8. QTL Information Table: 207 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Morphological trait Culm/leaf number of panicle RFLP C)Interval RIL Zhenshan 97B Milyang 46 RG65 ... .L. (2001). Comparison of the detection of QTL for yi eld traits in different generations of a rice cross ... using two mapping approaches. Yi ... Chuan Xue Bao 28, 458-464. ...

  9. 14 CFR 67.207 - Mental.

    Science.gov (United States)

    2010-01-01

    ... second-class airman medical certificate are: (a) No established medical history or clinical diagnosis of... sympathomimetics; hallucinogens; phencyclidine or similarly acting arylcyclohexylamines; cannabis; inhalants; and... Federal Air Surgeon, based on case history and appropriate, qualified medical judgment relating to...

  10. 20.7 Peripheral nerve disease

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930394 A1—10 year follow—up study of 82cases of methamidophos induced delayedpolyneuropathy.Z1HENG Rongyuan (郑荣远),etal.Neurol Dept,Wenzhou Med Coll.325000.Chin J Industr Hyg & Occupat Dis 1992;10(6):344—347.A1—10 year follow—up study of 82 cases ofmethamidophos induced delayed polyneuropathywas reported.82 cases were classified into threetypes:motor (36.6%),sensory—motor (61%)and Guillain-Barre syndrome (2.4%).As awhole,the sensory disturbances disappearedwithin 2—3 months;the autonomic nerve func-tional disorder vanished within 3—6 months;

  11. 19 CFR 207.91 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS OF WHETHER... applicant; Commission means the United States International Trade Commission; Commission Secretary means the... EXPORTS TO THE UNITED STATES Implementing Regulations for the North American Free Trade Agreement §...

  12. U/Pb (SHRIMP), {sup 207}Pb/{sup 206}Pb, Rb/Sr, Sm/Nd e K/Ar geochronology of granite-greenstone terrains of Gaviao Block: implications for the Proterozoic and Archean evolution of Sao Francisco Craton, Brazil; Geocronologia U/Pb (SHRIMP), {sup 207}Pb/{sup 206}Pb, Rb/Sr, Sm/Nd e K/Ar dos terrenos granito-greenstone do Bloco do Gaviao: implicacoes para a evolucao arqueana e proterozoica do craton do Sao Francisco, Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Leal, Luiz Rogerio Bastos

    1998-07-01

    The Gaviao Block (GB) in the northern portion of the Sao Francisco Craton-Northeast of Brazil, constitutes one of the oldest Archean fragments of the South American Platform Archean crust. GB underwent several events of juvenile accretion and reworking of continental crust along its evolutionary history, notably between the Archean and the Paleoproterozoic. {sup 207}Pb/{sup 206}Pb isotopic analyses were carried out in two zircons populations from strongly migmatized TTG terranes found in the proximity of Brumado: the first population (7 crystals) is taken as representative of the crystallization period of the TTG terranes at 3300 {+-} 45 Ma; the second (2 crystals) represents the age of the first even of metamorphism/migmatization at 2910 {+-} 10 Ma. {sup 207} Pb/{sup 206} Pb analyses in zircons from an outcrop of non-migmatized TTG in the area yielded a 3202 {+-} 15 Ma age (4 crystals), interpreted to be the crystallization period of the gneiss protolith. Sm/Nd analyses on the TTG rocks of the Brumado region yielded T{sub DM} model ages varying between 3.26 and 3.36 Ga and {epsilon}{sub Nd}{sup (t)} between -3.5 and +0.7. These data suggest the occurrence of juvenile accretions to the continental crust during the Archean, with differential involvement of crustal materials. The geochemical data of rare earth elements corresponding to the TTG terranes revealed moderate LRRE contents (La{sub N}=83,5), low HREE contents (La{sub N}=2,5) and a fairly fractionated pattern (La/Yb){sub N}=34, besides lack of negative Eu anomaly, showing that these rocks have similar compositions to those TTG terranes of cratonic continents, as well as some Archean rocks from CSF (e.g. Sete Voltas, Boa Vista). Finally, the youngest ages present in GB rocks (ca. 1.2-0.45 Ga) represent the role played by tectono thermal events, which produced partial or total rejuvenation of the Rb/Sr and K/Ar isotopic systems during the Espinhaco and Brasiliano cycles. In particular, K/Ar ages illustrate the

  13. Inclusive measurement of (p,πsup(-)xn) double charge exchange reactions on bismuth from threshold to 800 MeV

    International Nuclear Information System (INIS)

    The energy dependence of the total angle-integrated cross section for the production of astatine isotopes from (p,πsup(-)xn) double charge exchange reactions on bismuth (sup(209)Bi) was measured from 120 to 800 MeV using activation and radiochemical techniques. Chemical yields were estimated by direct radioassaying of sup(211)At activity in thin (approximately 1 mg/cmsup(2)), irradiated bismuth targets. Calculations of the contributions of secondary (2-step) reactions to these measured astatine yields were performed, based partially upon the observed sup(211)At activity although even at the highest energies, the contribution to products lighter than sup(207)At was negligible. These data for products with as many as 7 neutrons removed from the doubly coherent product (sup(210)At) display nearby gaussian shapes for the mass distributions of the astatine residues with the maximum occurring for about sup(204)At. The most probable momentum transfer deduced from these distributions for the initial πsup(-) production step was 335 MeV/c. The observed excitation functions display a behaviour similar to that observed for the yield of sup(210)Po from a (p,πsup(O)) reaction on sup(209)Bi, but radically different from that observed for inclusive πsup(-) reactions on a heavy nucleus. These data are discussed in terms of recent theoretical approaches to negative pion production from bismuth. In addition, a simple, schematic model is developed to treat the rapidly decreasing percentage of the total inclusive πsup(-) emission which is observed for this double charge exchange reaction. This model reflects the capacity of a nucleus to a source of internal energetic protons

  14. 农村留守中小学生问题行为及家庭影响因素分析%Study of problem behavior and their families influencing factors of 207 rural left-behind primary and secondary students

    Institute of Scientific and Technical Information of China (English)

    张雪琴; 龙永梅; 张哲; 何兰英; 邱晓娜; 王静进

    2011-01-01

    目的 了解农村留守中小学生的问题行为及家庭影响因素,为特殊群体的身心健康教育提供决策依据.方法 采用Conners儿童行为量表及白编家庭情况调查问卷,对207名小学和初中的留守学生进行调查.结果 留守中小学生的问题行为检出率为15.46%,其中品行问题检出率最高;留守中小学生的问题行为较非留守中小学生严重,其品行问题、多动、不注意-被动得分高于非留守中小学生;抚养人类别、文化程度及父母外出时间是影响留守中小学生的重要因素.结论 正常、温暖、有序的家庭环境是孩子健康成长的保证.农村留守中小学生的父母、抚养人、学校及社会应群策群力,减少中小学生行为问题的发生.%Objective To understand the problem behaviors and the influencing factors from their families of rural left-behind primary and secondary students, and to provide evidence for their mental health education. Methods Conners Child Behavior Scale, and self-compiled questionnaires to the families were used to investigate 207 elementary and junior high school students. Results The problem behavior detection rate of left-behind primary and secondary students was 15.46%, the highest detection rate were behavioral problems; the behavioral problems of home-left primary and secondary students were worse than non-left-behind students. Score of conduct problems, hyperactivity, no attention-passive were higher than score of non-left-behind students. Class and educational level of caregivers and how long their parents go out was an important affecting factor. Conclusion Normal ,warm, orderly family environment is to ensure the healthy growth of each child. Parents, caregivers, schools and society should work together to reduce home-left primary and secondary students' behavior problems.

  15. Residual nuclide formation in 206,207,208,natPb and 209Bi induced by 0.04 - 2.6 GeV protons as well as in 56Fe induced by 0.3 - 2.6 GeV protons

    International Nuclear Information System (INIS)

    This work is aimed at experimental determination of independent and cumulative yields of radioactive residual product nuclei in the intermediate energy proton-irradiated thin targets made of highly isotopic enriched and natural lead (206,207,208,natPb), bismuth (209Bi), and highly isotopic enriched iron (56Fe). 5972 independent and cumulative yields of radioactive residuals nuclei have been measured in 55 thin Pb and Bi targets irradiated by 0.04, 0.07, 0.10, 0.15, 0.25, 0.6, 0.8, 1.2, 1.4, 1.6, and 2.6 GeV protons. Besides, 219 yields have been measured in 0.3, 0.5, 0.75, 1.0, 1.5, and 2.6 GeV proton-irradiated Fe target. In both cases, the protons were extracted from the ITEP U-10 synchrotron. The measured data are compared with experimental results obtained elsewhere and with theoretical calculations by seven codes. The predictive power was found to be different for each of the codes tested, but was satisfactory on the whole in the case of spallation products. At the same time, none of the codes can describe well the product yields throughout the whole product mass range, and all codes must be further improved. (authors)

  16. 47 CFR 73.207 - Minimum distance separation between stations.

    Science.gov (United States)

    2010-10-01

    ... kW ERP and 100 meters antenna HAAT (or equivalent lower ERP and higher antenna HAAT based on a class... which have been notified internationally as Class A are limited to a maximum of 3.0 kW ERP at 100 meters... internationally as Class AA are limited to a maximum of 6.0 kW ERP at 100 meters HAAT, or the equivalent; (iii)...

  17. 48 CFR 207.103 - Agency-head responsibilities.

    Science.gov (United States)

    2010-10-01

    ... future requirements. This exception does not apply to a multiyear contract or a contract with options or... SMCA will review the acquisition plan to determine if it is consistent with retaining national... Law 105-261. The department or agency— (i) Shall submit the acquisition plan to the address in PGI...

  18. Dicty_cDB: VHQ207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available rvetltnhlcsssnesfyl ssnntdaslrelviraqaqrnarntktlkgleemktlvgkeigtseyfkitqdrvnsfae stgdfqwihidperaksespfggpiah...etltnhlcsssnesfyl ssnntdaslrelviraqaqrnarntktlkgleemktlvgkeigtseyfkitqdrvnsfae st

  19. Dicty_cDB: VSK207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available csn*lv rr*trcirfch*rygcr*kdgscwftir*nyqtsrhcqlwstlnyqhiafl**LIIIKRI DSIFFCXKK--- ---QGGDFTMGNGTGGESIYGNKFADE...qrwcqhqwftilylccsn*lv rr*trcirfch*rygcr*kdgscwftir*nyqtsrhcqlwstlnyqhiafl**LIIIKRI DSIFFCXKK--- ---srw*lyhg*...wyww*inlr*qic**klqiktfrsrytlngqrwcqhqwftilylccsn *lvrr*trcirfch*rygcr*kdgscwftir*nyqtsrhcqlwstlnyqhiafynn***

  20. Dicty_cDB: VFO207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 598422. 1197 0.0 1 ( BD092935 ) Methods and compositions for synthesis of long ch... 1197 0.0 1 ( BD082645 ) Methods and composition...s for synthesis of long ch... 1197 0.0 1 ( BD082630 ) Methods and composition

  1. 40 CFR 180.207 - Trifluralin; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... Barley, straw 0.05 Bean, mung, sprouts 2.0 Carrot, roots 1.0 Celery 0.05 Corn, field, forage 0.05 Corn, field, grain 0.05 Corn, field, stover 0.05 Cotton, gin byproducts 0.05 Cotton, undelinted seed 0.05..., group 8 0.05 Vegetable, leaves of root and tuber, group 2 0.05 Vegetable, legume, group 6 0.05...

  2. 5 CFR 2606.207 - Accounting of disclosures.

    Science.gov (United States)

    2010-01-01

    ... Ethics in Government Act, 18 U.S.C. 208(d) and 5 CFR parts 2634 and 2640 of OGE's executive branch... of disclosures for these records. (d) Except for the accounting of a disclosure made under subsection... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Accounting of disclosures....

  3. Dicty_cDB: SHL207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available GYSLNNNFYISETPFSLASTTHIDKTFISTNKE AIIVDTIKKAEDGTSFVVRVYESFGGATTFNFTSSILPIPFKSIIECNGLEEVNQSSKSY KFNDTIKINPFEIKTFRFISN*klkiklinky...DTIKINPFEIKTFRFISN*klkiklinkyknkf Translated Amino Acid sequence (All Frames) Frame A: ---*hklgfrki*scrt*mgr...ASTTHIDKTFISTNKE AIIVDTIKKAEDGTSFVVRVYESFGGATTFNFTSSILPIPFKSIIECNGLEEVNQSSKSY KFN

  4. 33 CFR 143.207 - Requirements for foreign MODUs.

    Science.gov (United States)

    2010-07-01

    ... equipment standards of 46 CFR part 108. (b) The design and equipment standards of the documenting nation if... CFR part 108. (c) The design and equipment standards for mobile offshore drilling units contained in... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Requirements for foreign...

  5. 27 CFR 9.207 - Outer Coastal Plain.

    Science.gov (United States)

    2010-04-01

    ... the Delaware River (within Mad Horse Creek State Wildlife Management Area) in Salem County; (2) From... Route (SR) 49; then (4) Proceed northwesterly on SR 49 to its intersection with SR 45 in the center...

  6. 38 CFR 3.207 - Void or annulled marriage.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Void or annulled marriage... Void or annulled marriage. Proof that a marriage was void or has been annulled should consist of: (a... marriage void, together with such other evidence as may be required for a determination. (b) Annulled....

  7. Translating cultural transition in Kgebetli Moele’s Room 207

    Directory of Open Access Journals (Sweden)

    S.S. Ibinga

    2010-07-01

    Full Text Available This article deals with the issue of cultural translation in a postapartheid text through the analysis of language, setting and discourse to highlight cultural transition in a society where socio-political mutations elicit new literary codes and symbols. The discussion is developed around concepts such as gender and ethnic identity or citizenship in a geographical environment where multi- and transcultural identities are endlessly being contested. The concept of translation is explored to show how Moele’s text represents cultural transition within a postapartheid urban context by analysing the authorial transposition of everyday experience into the textual fabric. The article also examines how the narrative voice negotiates across the current multicultural divide in order to highlight cultural change both in South African literature and in society as a whole. This article addresses in the discussion the controversial debate raised by Michael Titlestad’s (2007 review of the book published in the “Sunday times” on 25 March in which the critic evinces a negative reception of the book. This is used as a point of departure in order to explore a wide range of possibilities that fiction can offer by means of textual representation of the daily experience of black people in a postapartheid urban context.

  8. 30 CFR 207.5 - Contract and sales agreement retention.

    Science.gov (United States)

    2010-07-01

    ... production are to be maintained by the lessee and made available upon request during normal working hours to authorized MMS, State or Indian representatives, other MMS or BLM officials, auditors of the General... with 30 CFR part 212....

  9. 21 CFR 207.30 - Updating drug listing information.

    Science.gov (United States)

    2010-04-01

    ...) DRUGS: GENERAL REGISTRATION OF PRODUCERS OF DRUGS AND LISTING OF DRUGS IN COMMERCIAL DISTRIBUTION... section and for which commercial distribution has been resumed, including for each drug so listed the NDC... introduced by the registrant for commerical distribution which has not been included in any list...

  10. 24 CFR 207.257 - Commissioner's right to require acceleration.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Commissioner's right to require... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES MULTIFAMILY HOUSING MORTGAGE INSURANCE Contract Rights and Obligations Rights and Duties...

  11. 24 CFR 207.256a - Reinstatement of defaulted mortgage.

    Science.gov (United States)

    2010-04-01

    ... the Commissioner, in the manner prescribed in 24 CFR part 200, subpart B. ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Reinstatement of defaulted mortgage... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND...

  12. Population Pharmacokinetics of Bedaquiline (TMC207), a Novel Antituberculosis Drug

    OpenAIRE

    McLeay, Sarah C.; Vis, Peter; van Heeswijk, Rolf P. G; Green, Bruce

    2014-01-01

    Bedaquiline is a novel agent for the treatment of pulmonary multidrug-resistant Mycobacterium tuberculosis infections, in combination with other agents. The objective of this study was to develop a population pharmacokinetic (PK) model for bedaquiline to describe the concentration-time data from phase I and II studies in healthy subjects and patients with drug-susceptible or multidrug-resistant tuberculosis (TB). A total of 5,222 PK observations from 480 subjects were used in a nonlinear mixe...

  13. Dicty_cDB: SHC207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available m adolescentis ATC... 164 2e-39 ( P12045 ) RecName: Full=Phosphoribosylaminoimidazole carboxylase ... 164 2e...HWTIEGCVTSQFEQLIRCV CGLPLGSVDFTKSXXSV Translated Amino Acid sequence (All Frames) Fram...yvkplhqlncqnifinkpmklv* rllvpmvwlvllpsnyl**ktmkqvntl*w*mnwhqdhtivvigpskvv*plnlnn*fvv fvvclwvqsislkvsxqw Fram...nce update 2002. 9.10 Translated Amino Acid sequence ---SFNDLKSAIEKIGYPAILKSNTMGYDGKGQVKLTDQVDLEQAWKKVTSETCA...c survey sequence. 44 3.3 1 CW222532 |CW222532.1 104_658_11202424_148_37183_064 Sorghum methylati

  14. 46 CFR 13.207 - Eligibility: Firefighting course.

    Science.gov (United States)

    2010-10-01

    ... applicant for an original “Tankerman-PIC” endorsement shall present a certificate of successful completion... years of the date of application for the endorsement, unless he or she has previously submitted such...

  15. 48 CFR 1517.207 - Exercise of options.

    Science.gov (United States)

    2010-10-01

    ....705-1(a), exercise an option contingent upon the availability of funds. To exercise such an option... shall any action be taken which could be construed as creating a legal liability on the part of...

  16. 33 CFR 207.800 - Collection of navigation statistics.

    Science.gov (United States)

    2010-07-01

    ... susceptible to use to transport interstate or foreign commerce. (See 33 CFR part 329 for a more complete... exemption codes are listed in the directions for ENG Form 3925. (3) Refer to 19 CFR part 24 for detailed... is authorized to assess a civil penalty in accordance with the Class I penalty provisions of 33...

  17. 48 CFR 15.207 - Handling proposals and information.

    Science.gov (United States)

    2010-10-01

    ... CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and... proposal received by the contracting officer electronically or by facsimile is unreadable, the...

  18. Dicty_cDB: SHI207 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available f query: 148 length of database: 80,480,566 effective HSP length: 17 effective length of query: 131 effective... length of database: 78,821,179 effective search space: 10325574449 effective se...er of sequences better than 10.0: 0 length of query: 148 length of database: 61,296,806,322 effective HSP length: 22 effective... length of query: 126 effective length of database: 60,048,944,916 effective search space: 7566167059416 effective

  19. 44 CFR 206.207 - Administrative and audit requirements.

    Science.gov (United States)

    2010-10-01

    ... administrative requirements of 44 CFR parts 13 and 206; (H) Compliance with the audit requirements of 44 CFR part... in FEMA regulations at 44 CFR part 13 or OMB Circular A-110 as appropriate. (2) Federal audit. In accordance with 44 CFR part 13, FEMA may elect to conduct a Federal audit of the disaster assistance grant...

  20. Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

    Energy Technology Data Exchange (ETDEWEB)

    Green, Damian J.; Shadman, Mazyar; Jones, Jon C.; Frayo, Shani; Kenoyer, Aimee L.; Hylarides, Mark; Hamlin, Donald K.; Wilbur, D. Scott; Balkan, Ethan R.; Lin, Yukang; Miller, Brian W.; Frost, Sophia; Gopal, Ajay K.; Orozco, Johnnie J.; Gooley, Ted; Laird, Kelley L.; Till, B. G.; Back, Tom; Sandmaier, B. M.; Pagel, John M.; Press, Oliver W.

    2015-03-26

    Alpha emitting radionuclides release a large amount of energy within a few cell diameters and may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD) conditions in which micrometastatic disease satellites are broadly distributed. To evaluate this hypothesis, 211At conjugated 1F5 mAb (anti-CD20) was studied in both bulky lymphoma tumor xenograft and MRD animal models. Superior treatment responses to 211At conjugated 1F5 mAb were evident in the MRD setting. Lymphoma xenograft tumor bearing animals treated with doses of up to 48µCi of anti-CD20 211At-decaborate [211At-B10-1F5] experienced modest responses (0% cures but 2-3-fold prolongation of survival compared to negative controls). In contrast, 70% of animals in the MRD lymphoma model demonstrated complete eradication of disease when treated with 211At-B10-1F5 at a radiation dose that was less than one-third (15 µCi) of the highest dose given to xenograft animals. Tumor progression among untreated control animals in both models was uniformly lethal. After 130 days, no significant renal or hepatic toxicity is observed in the cured animals receiving 15 µCi of 211At-B10-1F5. These findings suggest that in a MRD lymphoma model, where isolated cells and tumor microclusters prevail, α-emitters may be uniquely efficacious.

  1. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE,CERN

    OpenAIRE

    Rothe, Sebastian

    2012-01-01

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spec...

  2. Inactivation of human osteosarcoma cells in vitro by {sup 211}At-TP-3 monoclonal antibody: Comparison with astatine-211 and external-beam X rays

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, R.H. [Univ. of Oslo (Norway)]|[Institute for Cancer Research, Oslo (Norway); Bruland, O.S. [Institute for Cancer Research, Oslo (Norway); Hoff, P.; Alstad, J. [Univ. of Oslo (Norway); Lindmo, T. [Institute for Cancer Research, Oslo (Norway); Rofstad, E.K. [Norwegian Institute of Technology, Trondheim (Norway)

    1994-08-01

    The potential usefulness of {alpha}-particle radioimmunotherapy in the treatment of osteosarcoma was studied in vitro by using the monoclonal antibody TP-3 and cells of three human osteosarcoma cell lines (OHS, SAOS and KPDX) differing in antigen expression. Cell survival curves were established after treatment with (a) {sup 211}At-TP-3 of different specific activities, (b) {sup 211}At-labeled bovine serum albumin (BSA), (c) free {sup 211}At and (d) external-beam X rays. The three osteosarcoma cell lines showed similar survival curves, whether treated with external-beam X rays, {sup 211}At-BSA or free {sup 211}At. The D{sub o}`s were lower for free {sup 211}At than for {sup 211}At-BSA. The survival curves for {sup 211}At-TP-3 treatment, on the other hand, differed significantly among the cell lines, suggesting that sensitivity to {sup 211}At-TP-3 treatment was governed by cellular properties other than sensitivity to external-beam X rays. The cellular property most important for sensitivity to {sup 211}At-TP-3 treatment was the antigen expression. Cell inactivation after {sup 211}At-TP-3 treatment increased substantially with increasing specific activity of the {sup 211}At-TP-3. At high specific activities, the cytotoxic effect of {sup 211}At-TP-3 was significantly higher than that of {sup 211}At-BSA. In conclusion, {sup 211}At-TP-3 has the potential to give clinically favorable therapeutic ratios in the treatment of osteosarcoma. 39 refs., 5 figs., 2 tabs.

  3. India's Information Technology Sector: What Contribution to Broader Economic Development? OECD Development Centre Working Paper, No. 207 (Formerly Technical Paper No. 207)

    Science.gov (United States)

    Singh, Nirvikar

    2003-01-01

    What contribution can information technology (IT) make to India's overall economic development? This paper provides an analytical framework centred around the concepts of comparative advantage, complementarities, and innovation. There is strong evidence that India has a strong and sustainable comparative advantage in software development and…

  4. 76 FR 5518 - Federal Housing Administration (FHA): Refinancing an Existing Cooperative Under Section 207...

    Science.gov (United States)

    2011-02-01

    ..., HUD's current regulations limit FHA insurance to existing rental projects. Given the current crisis in...) the aggressive underwriting standards that characterized the subprime home mortgage market were mirrored in the multifamily mortgage market. While subprime mortgagees used hybrid...

  5. Estudo retrospectivo de 207 casos de tumores mamários em gatas

    Directory of Open Access Journals (Sweden)

    Monique Togni

    2013-03-01

    Full Text Available Este estudo teve como objetivos determinar os tumores mais prevalentes em gatos e relacionar os tumores mamários a alguns de seus fatores prognósticos. Os arquivos do Laboratório de Patologia Veterinária (LPV da Universidade Federal de Santa Maria (UFSM foram revisados e um total de 1.427 protocolos de biopsias e necropsias de felinos, entre 2000 e 2011, foi encontrado. Com base nas informações dos arquivos, foi estabelecida a relação entre os tumores e alguns fatores como sexo, idade, raça, estado reprodutivo, uso de contraceptivos, número e localização das glândulas afetadas, ulcerações, tamanho do neoplasma, metástases distantes e para os linfonodos. Assim, observou-se que os tumores de mama foram o segundo diagnóstico mais prevalente, após os tumores de pele. Todos os gatos com tumores mamários eram fêmeas, sendo os sem raça definida e os idosos os mais afetados. Os neoplasmas malignos foram diagnosticados com maior frequência, seguidos pelos tumores não neoplásicos e pelos neoplasmas benignos. Os tumores menores eram, na sua maioria, carcinomas. Ulcerações estavam presentes não só em neoplasmas malignos, mas também em alterações não neoplásicas. Metástases distantes foram encontradas principalmente nos pulmões e na pele.

  6. Candida Osteomyelitis: Analysis of 207 Pediatric and Adult Cases (1970–2011)

    OpenAIRE

    Gamaletsou, Maria N; Kontoyiannis, Dimitrios P.; Sipsas, Nikolaos V.; Moriyama, Brad; Alexander, Elizabeth; Roilides, Emmanuel; Brause, Barry; Thomas J Walsh

    2012-01-01

    Candida osteomyelitis most frequently presents subacutely with local symptoms but minimally elevated inflammatory biomarkers, hematogenous dissemination caused by C. albicans involving vertebrae in adults and femur/humerus in children, high relapse rate requiring extended therapy (median 3 months), and often surgical intervention.

  7. 精致生活——东风标致207两厢

    Institute of Scientific and Technical Information of China (English)

    吴中元; 丛军(摄影)

    2009-01-01

    一直想要一种精致的生活,但这样的精致究竟要如何实现,自己却又说不清楚。是在疲惫的午间休息时间抱一个超大杯的Starbucks吗?抑或是不时去法式餐厅体会红酒中单宁留在口中微微发涩的感觉?

  8. Calibration of ground-based lidar instrument WLS7-207

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Courtney, Michael

    This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbine at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement...... uncertainties provided by measurement standard and corresponding lidar wind speed indications with associated measurement uncertainties. The lidar calibration concerns the 10 minute mean wind speed measurements. The comparison of the lidar measurements of the wind direction with that from wind vanes...... measurements are given for information only....

  9. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (207a-0613-272217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  10. 33 CFR 207.20 - Cape Cod Canal, Mass.; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... are defined as those items listed in 33 CFR 126.10 when carried in bulk (i.e., quantities exceeding 110 U.S. gallons in one tank) plus Class A explosives (commercial or military) as listed in 49 CFR 173.53 (commercial) and 46 CFR 146.29-100 (military), liquified natural gas and liquified petroleum...

  11. 33 CFR 207.9 - Mystic River, Mass.; dam of Commonwealth of Massachusetts, Metropolitan District Commission.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Mystic River, Mass.; dam of... Mystic River, Mass.; dam of Commonwealth of Massachusetts, Metropolitan District Commission. (a... Massachusetts, M.D.C. Parks Division, Boston, Mass.; New England Division, Corps of Engineers, Division...

  12. 76 FR 207 - Intent To Prepare an Environmental Impact Statement for Proposed Transit Improvements to the...

    Science.gov (United States)

    2011-01-03

    ... scoping meetings or they may be sent to Mr. Steve Hands, Strategic Planning and Policy, Chicago Transit... times, improving access to job markets, responding to shifts in travel demand, better utilizing...

  13. 33 CFR 207.50 - Hudson River Lock at Troy, N.Y.; navigation.

    Science.gov (United States)

    2010-07-01

    ... petroleum products other than gasoline, provided a clear distance of at least 100 feet between such vessels..., satisfactory to the District Engineer, Corps of Engineers, New York, New York, that the regulations will...

  14. 24 CFR 982.207 - Waiting list: Local preferences in admission to program.

    Science.gov (United States)

    2010-04-01

    ..., color, ethnic origin, gender, religion, disability, or age of any member of an applicant family. (iv) A... crime of violence (as defined in 18 U.S.C. 16). (b) Particular local preferences—(1) Residency...) Preference for victims of domestic violence. The PHA should consider whether to adopt a local preference...

  15. Tank 241-T-105, cores 205 and 207 analytical results for the final report

    International Nuclear Information System (INIS)

    This document is the final laboratory report for tank 241-T-105 push mode core segments collected between June 24, 1997 and June 30, 1997. The segments were subsampled and analyzed in accordance with the Tank Push Mode Core Sampling and Analysis Plan (TSAP) (Field,1997), the Tank Safety Screening Data Quality Objective (Safety DQO) (Dukelow, et al., 1995) and Tank 241-T-105 Sample Analysis (memo) (Field, 1997a). The analytical results are included in Table 1. None of the subsamples submitted for the differential scanning calorimetry (DSC) analysis or total alpha activity (AT) exceeded the notification limits as stated in the TSAP (Field, 1997). The statistical results of the 95% confidence interval on the mean calculations are provided by the Tank Waste Remediation Systems (TWRS) Technical Basis Group in accordance with the Memorandum of Understanding (Schreiber, 1997) and not considered in this report

  16. 21 CFR 207.20 - Who must register and submit a drug list.

    Science.gov (United States)

    2010-04-01

    ... (CONTINUED) DRUGS: GENERAL REGISTRATION OF PRODUCERS OF DRUGS AND LISTING OF DRUGS IN COMMERCIAL DISTRIBUTION... drugs shall register and submit a list of every drug in commercial distribution (except that..., storage, or distribution of human cells, tissues, and cellular and tissue-based products, as defined...

  17. 24 CFR 207.252e - Method of payment of mortgage insurance premiums.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Method of payment of mortgage... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES MULTIFAMILY HOUSING MORTGAGE INSURANCE Contract Rights and...

  18. 24 CFR 207.259a - Waiver of title objection; mortgages formerly Commissioner-held.

    Science.gov (United States)

    2010-04-01

    ... HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES MULTIFAMILY HOUSING MORTGAGE INSURANCE Contract Rights... title objection; mortgages formerly Commissioner-held. If the Commissioner sells a mortgage and...

  19. 78 FR 40194 - Proposed Information Collection Request of the ETA 207, Nonmonetary Determination Activities...

    Science.gov (United States)

    2013-07-03

    ..., Office of Unemployment Insurance, 200 Constitution Avenue NW., Frances Perkins Bldg. Room S- 4524... Activities, contains state data on the number and types of issues that are adjudicated when unemployment... continuing eligibility for benefits. These data are used by the Office of ] Unemployment Insurance (OUI)...

  20. Substitute potting compounds for Sylgard 93-120. Process Development Endeavor Nos. 203 and 207

    Energy Technology Data Exchange (ETDEWEB)

    Flowers, G.L.; Switzer, S.T.

    1979-07-01

    The report deals with the development of substitute potting compounds to replace the no longer available Dow Corning 93-120. Three different approaches to formulate a substitute, two of which were successful are presented. The efforts discussed are a part of a laarger project to better understand the silicone potting compound technology and to formulate substitutes for specific materials which have been discontinued by Dow Corning.

  1. 19 CFR 207.93 - Protection of proprietary information during panel and committee proceedings.

    Science.gov (United States)

    2010-04-01

    ... competitive decision-making, as defined in US Steel Corp. v. United States, 730 F.2d 1465 (Fed. Cir. 1984), for the person represented or for any person that would gain a competitive advantage through knowledge... the proceeding or of any person that would gain a competitive advantage through knowledge of...

  2. 34 CFR 682.207 - Due diligence in disbursing a loan.

    Science.gov (United States)

    2010-07-01

    ... institution of higher education. (C) In the case of a student enrolled in a study-abroad program approved for... study-abroad program, prior to each disbursement of Stafford loan funds directly to a student by— (A... enrollment status for which the loan was certified. (B) For a student enrolled in a study-abroad...

  3. DE0823-49 is a juvenile binary brown dwarf at 20.7 pc

    Science.gov (United States)

    Sahlmann, J.; Burgasser, A. J.; Martín, E. L.; Lazorenko, P. F.; Bardalez Gagliuffi, D. C.; Mayor, M.; Ségransan, D.; Queloz, D.; Udry, S.

    2015-07-01

    Astrometric monitoring of the nearby early-L dwarf DE0823-49 has revealed a low-mass companion in a 248-day orbit that was announced in an earlier work. Here, we present new astrometric and spectroscopic observations that allow us to characterise the system in detail. The optical spectrum shows Li i-absorption indicative of a young age and/or substellar mass for the primary component. The near-infrared spectrum is best reproduced by a binary system of brown dwarfs with spectral types of L1.5 + L5.5 and effective temperatures of 2150 ± 100 K and 1670 ± 140 K. To conform with the photocentric orbit size measured with astrometry and the current understanding of substellar evolution, the system must have an age in the 80-500 Myr range. Evolutionary models predict component masses in the ranges of M1 ≃ 0.028-0.063 M⊙ and M2 ≃ 0.018-0.045 M⊙ with a mass ratio of q ≃ 0.64-0.74. Multi-epoch radial velocity measurements unambiguously establish the three-dimensional orbit of the system and allow us to investigate its kinematic properties. DE0823-49 emerges as a rare example of a nearby brown dwarf binary with orbit, component properties, and age that are characterised well. It is a juvenile resident of the solar neighbourhood, but does not appear to belong to a known young association or moving group. Based on observations made with ESO telescopes at the La Silla Paranal Observatory under programme IDs 086.C-0680, 088.C-0679, 090.C-0786, and 092.C-0202.

  4. 49 CFR 232.207 - Class IA brake tests-1,000-mile inspection.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Class IA brake tests-1,000-mile inspection. 232... Class IA brake tests—1,000-mile inspection. (a) Except as provided in § 232.213, each train shall receive a Class IA brake test performed by a qualified person, as defined in § 232.5, at a location...

  5. 20 CFR 416.207 - You do not give us permission to contact financial institutions.

    Science.gov (United States)

    2010-04-01

    ...: (1) Bank, (2) Savings bank, (3) Credit card issuer, (4) Industrial loan company, (5) Trust company, (6) Savings association, (7) Building and loan, (8) Homestead association, (9) Credit union, (10... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false You do not give us permission to...

  6. Bataan nuclear power plant unit no. 1. Progress report no. 207

    International Nuclear Information System (INIS)

    This report presents the accomplishment of the National Power Corporation (NPC) for the month of August 1994. The highlights of the report were the following: a) issuance of preservation task orders; b) total expenses for the preservation and maintenance of the plant; c) completion of underwater structures and fabrication of the stop logs; d) repaired of two dry type transformers; e) inventory of excess construction materials; and f) investigations of vehicular accident. Also in this period, delegates from different institutions and organizations and schools were given briefings and tour of the plant facilities as part of public information campaign. ills

  7. Retrospective Cohort Study of 207 Cases of Osteochondritis Dissecans of the Knee

    Science.gov (United States)

    Green, Daniel W.; Arbucci, John; Silberman, Jason; Luderowski, Eva; Uppstrom, Tyler J.; Nguyen, Joseph; Tuca, Maria

    2016-01-01

    Objectives: Describe the clinical characteristics, image findings, and outcomes of patients with juvenile osteochondritis dissecans (JOCD) of the knee. To our knowledge, this is the largest single-surgeon cohort of JOCD patients. Methods: Retrospective cohort study of knee JOCD patients assessed by a single pediatric orthopaedic surgeon at a tertiary care center between 2005-2015. All diagnoses were confirmed by magnetic resonance imaging (MRI). Patients with patellar dislocations or osteochondral fractures were excluded. Demographic data, sports played, comorbidities, surgical procedures, and clinical data were extracted from charts. Images were analyzed to identify the location and size of lesions. Chi-square or Fisher’s exact tests were used to compare discrete variables, and Mann-Whitney U and Kruskal Wallis tests to compare continuous variables between groups. P-values of basketball (29.4%). JOCD was present bilaterally in 27 patients (15%), 14 knees had bifocal OCD (6.8%), and only 1 patient had bifocal lesions in both knees. Most common location was medial femoral condyle (56.3%) followed by lateral femoral condyle (23.1%), trochlea (11.4%), patella (9%), and tibia (0.5%). In the sagittal view, most common location was the middle third of the condyles (48.7%). Surgery was performed in 72 knees (34.8%), with an average age at surgery of 14.1 years (9.3-18.1). Bilateral JOCD was present in 13 surgical patients (18.8%), but only 3 patients had bilateral surgery. Two operative patients had bifocal JOCD (2.7%) and surgery on both lesions. Location distribution did not differ between surgical and non-surgical lesions. The average normalized area of non-surgical JOCD lesions was 6.8 (0.1-18), whereas surgical lesions averaged a significantly higher area of 7.7 (0.5-17) (p=0.023). Average BMI was 21.6 versus 20.2 for surgical and non-surgical patients, respectively, significantly higher for those who underwent surgery (p=0.002). Most common procedure was fixation with 1.6 mm bioabsorbable nails (54.2%), using an average of 4 nails (1-9). Only 2 cases were fixed using metallic headless screws. Other surgical treatments were drilling (13.9%), microfracture (13.9%), microfracture + fixation (6.9%), removal of loose body/chondroplasty (6.9%), and allograft transplantation (4.2%). Fixation was achieved all-arthroscopic in 43.1% of the cases, and 61.3% of the lesions that were fixed underwent curettage of the subchondral bone. Revision surgery was required in 14 knees (19.4%). The most common revision procedures were microfracture, removal of hardware, chondroplasty and allograft implantation, where some revisions had combined procedures. Most surgical patients had postoperative MRIs (55 knees), with an average radiological follow-up of 14.5 months (range 2.1-55.4). Conclusion: JOCD occurs more frequently in young adolescent athlete boys, affecting the middle third of the medial femoral condyle. In our cohort, 1/3 of the patients had surgery, where bigger lesions and higher BMI were risk factors for operative treatment. At short-term follow up, the success rate following surgery was above 80%.

  8. 49 CFR 234.207 - Adjustment, repair, or replacement of component.

    Science.gov (United States)

    2010-10-01

    ...) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GRADE CROSSING SIGNAL SYSTEM SAFETY AND..., repair, or replacement of component. (a) When any essential component of a highway-rail grade...

  9. 33 CFR 207.440 - St. Marys Falls Canal and Locks, Mich.; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... not unduly delay the transit of vessels of lesser dimensions, or endanger the lock structure because... language, may, in the discretion of the District Engineer or his authorized agents, be denied...

  10. DE0823$-$49 is a juvenile binary brown dwarf at 20.7 pc

    CERN Document Server

    Sahlmann, J; Martín, E L; Lazorenko, P F; Gagliuffi, D C Bardalez; Mayor, M; Ségransan, D; Queloz, D; Udry, S

    2015-01-01

    Astrometric monitoring of the nearby early-L dwarf DE0823$-$49 has revealed a low-mass companion in a 248-day orbit that was announced in an earlier work. Here, we present new astrometric and spectroscopic observations that allow us to characterise the system in detail. The optical spectrum shows LiI-absorption indicative of a young age and/or substellar mass for the primary component. The near-infrared spectrum is best reproduced by a binary system of brown dwarfs with spectral types of L1.5 $+$ L5.5 and effective temperatures of $2150\\pm100$ K and $1670\\pm140$ K. To conform with the photocentric orbit size measured with astrometry and the current understanding of substellar evolution, the system must have an age in the 80--500 Myr range. Evolutionary models predict component masses in the ranges of $M_1\\simeq0.028-0.063\\,M_\\odot$ and $M_2\\simeq0.018-0.045\\,M_\\odot$ with a mass ratio of $q\\simeq0.64-0.74$. Multi-epoch radial velocity measurements unambiguously establish the three-dimensional orbit of the sys...

  11. 31 CFR 537.207 - Effect of transfers violating the provisions of this part.

    Science.gov (United States)

    2010-07-01

    ... the same extent that it would be valid or enforceable but for the provisions of the International Emergency Economic Powers Act (50 U.S.C. 1701-1706), this part, and any regulation, order, directive, ruling... by law or unless licensed pursuant to this part, any attachment, judgment, decree, lien,...

  12. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (207a-0613-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  13. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (207b-0613-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  14. Shelf-Life of ɛ-Lysyl-3-(Trimethylstannyl)Benzamide Immunoconjugates, Precursors for 211At Labeling of Antibodies

    OpenAIRE

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per; Jensen, Holger; Holgersson, Stellan; Lindegren, Sture

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity and the complex radiochemistry of 211At are major obstacles for research and prospective clinical applications. In the present study, astatination of immunoconjugates, already prepared well in advance...

  15. 207株肺炎克雷伯菌临床分布及耐药性分析%Clinical distribution and drug resistance analysis of 207 Klebsiella pneumoniae strains

    Institute of Scientific and Technical Information of China (English)

    龙绍芬; 黎铁斌

    2012-01-01

    目的 分析临床分离肺炎克雷伯菌对抗菌药物的耐药性.方法 对临床分离肺炎克雷伯菌用纸片扩散法(K-B)或微量稀释法对16种抗菌药物进行药物敏感试验.结果 产超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌59株,对头孢曲松、头孢呋辛、头孢噻肟、头孢哌酮、头孢噻吩、复方新诺明、美洛西林有很高的耐药率,分别是91.53%、91.53%、100.00%、100.00%、93.22%、72.88%和91.53%,甚至出现多重耐药菌株.结论 产ESBLs肺炎克雷伯菌耐药情况非常严重,应加强医院感染监测和控制措施.%Objective To analyse the drug resistance of Klebsiella pneumoniae. Methods the disk diffusion method (KB) or mi cro dilution method (MIC) was used to detect the resistance rates of Klebsiella pneumoniae clinical isolates to 16 kinds of antibacte rial drugs. Results There were 59 strains of Klebsiella pneumoniae producing extended spectrum |3 lactamase (ESBLs) ,and they had high resistance rates to ceftriaxone(91. 53%) ,cefuroxime(91. 53%) , cefotaxime(100. 00%) ,cefoperazone(100. 00%) ,cepha lothin(93. 22%) ,co trimoxazole(72. 88%) ,mezlocillin(91. 53%) respectively. There are even multi drug resistant strains were de tected. Conclusion The drug resistance of ESBLs producing Klebsiella pneumoniae is very serious. The hospital infection surveil lance and control measures should be strengthen.

  16. Feather lead concentrations and207Pb/206Pb ratios reveal lead exposure history of California condors (Gymnogyps californianus)

    Science.gov (United States)

    Finkelstein, M.E.; George, D.; Scherbinski, S.; Gwiazda, R.; Johnson, M.; Burnett, J.; Brandt, J.; Lawrey, S.; Pessier, Allan P.; Clark, M.; Wynne, J.; Grantham, And J.; Smith, D.R.

    2010-01-01

    Lead poisoning is a primary factor impeding the survival and recovery of the critically endangered California Condor (Gymnogyps californianus). However, the frequency and magnitude of lead exposure in condors is not well-known in part because most blood lead monitoring occurs biannually, and biannual blood samples capture only ???10% of a bird's annual exposure history. We investigated the use of growing feathers from free-flying condors in California to establish a bird's lead exposure history. We show that lead concentration and stable lead isotopic composition analyses of sequential feather sections and concurrently collected blood samples provided a comprehensive history of lead exposure over the 2-4 month period of feather growth. Feather analyses identified exposure events not evident from blood monitoring efforts, and by fitting an empirically derived timeline to actively growing feathers, we were able to estimate the time frame for specific lead exposure events. Our results demonstrate the utility of using sequentially sampled feathers to reconstruct lead exposure history. Since exposure risk in individuals is one determinant ?? 2010 American Chemical Society.

  17. Physical therapy in relation to gait and balance in elderly women - doi:10.5020/18061230.2011.p207

    Directory of Open Access Journals (Sweden)

    Anniele Martins Silva

    2012-01-01

    Full Text Available Objective: To determine if there is a benefit of physical therapy intervention in relation to balance and gait in the elderly. Methods: An interventional study held in 2009 in Caruaru-PE, Brazil, evaluated elderly women aged 60 and 82 years, randomly divided into two groups, control and intervention, undergoing physical therapy assessment (posture, balance and mobility through Timed Get Up and Go Test scorings- TUG, analysis of socio-demographic profile (age, sex, history of falls, fear of falling, physical activity, smoking and drinking and physical therapy intervention for 10 weeks. Statistical analysis included chi-square test, Fisher’s exact and ANOVA. Results: We found that the risk of falls was more evident in the control group (p <0.05 regarding to the scores and rankings obtained in the TUG test. After the intervention, no participant in the experimental group reported fear of falling, and no longer reported the presence of pain. Conclusion: Physical therapy achieved through stretching exercises and training of balance and strength brought benefits to both the balance and the gait of the studied sample.

  18. Physical therapy in relation to gait and balance in elderly women - doi:10.5020/18061230.2011.p207

    OpenAIRE

    Anniele Martins Silva; Rosane Batista e Silva; Ricardo Alexandre Guerra; Gisela Rocha de Siqueira

    2012-01-01

    Objective: To determine if there is a benefit of physical therapy intervention in relation to balance and gait in the elderly. Methods: An interventional study held in 2009 in Caruaru-PE, Brazil, evaluated elderly women aged 60 and 82 years, randomly divided into two groups, control and intervention, undergoing physical therapy assessment (posture, balance and mobility through Timed Get Up and Go Test scorings- TUG), analysis of socio-demographic profile (age, sex, history of falls, fear of f...

  19. 33 CFR 207.180 - All waterways tributary to the Gulf of Mexico (except the Mississippi River, its tributaries...

    Science.gov (United States)

    2010-07-01

    ... through with commercial craft (other than vessels carrying dangerous cargoes, as described in 46 CFR part..., and the Atchafalaya River above its junction with the Morgan City-Port Allen Route. (2) Locks and... floating craft other than rafts. (5) Rafts. The term “raft” as used in this section includes any and...

  20. SU-C-207-01: Four-Dimensional Inverse Geometry Computed Tomography: Concept and Its Validation

    International Nuclear Information System (INIS)

    Purpose: In past few years, the inverse geometry computed tomography (IGCT) system has been developed to overcome shortcomings of a conventional computed tomography (CT) system such as scatter problem induced from large detector size and cone-beam artifact. In this study, we intend to present a concept of a four-dimensional (4D) IGCT system that has positive aspects above all with temporal resolution for dynamic studies and reduction of motion artifact. Methods: Contrary to conventional CT system, projection data at a certain angle in IGCT was a group of fractionated narrow cone-beam projection data, projection group (PG), acquired from multi-source array which have extremely short time gap of sequential operation between each of sources. At this, for 4D IGCT imaging, time-related data acquisition parameters were determined by combining multi-source scanning time for collecting one PG with conventional 4D CBCT data acquisition sequence. Over a gantry rotation, acquired PGs from multi-source array were tagged time and angle for 4D image reconstruction. Acquired PGs were sorted into 10 phase and image reconstructions were independently performed at each phase. Image reconstruction algorithm based upon filtered-backprojection was used in this study. Results: The 4D IGCT had uniform image without cone-beam artifact on the contrary to 4D CBCT image. In addition, the 4D IGCT images of each phase had no significant artifact induced from motion compared with 3D CT. Conclusion: The 4D IGCT image seems to give relatively accurate dynamic information of patient anatomy based on the results were more endurable than 3D CT about motion artifact. From this, it will be useful for dynamic study and respiratory-correlated radiation therapy. This work was supported by the Industrial R&D program of MOTIE/KEIT [10048997, Development of the core technology for integrated therapy devices based on real-time MRI guided tumor tracking] and the Mid-career Researcher Program (2014R1A2A1A10050270) through the National Research Foundation of Korea funded by the Ministry of Science, ICT&Future Planning

  1. 33 CFR 207.300 - Ohio River, Mississippi River above Cairo, Ill., and their tributaries; use, administration, and...

    Science.gov (United States)

    2010-07-01

    ... project depth is not available. A red nun-type buoy will be used for such structures located on the left... type and color (red nun or black can buoy) until covered by a depth of water equal to the project...

  2. SU-D-207-01: Markerless Respiratory Motion Tracking with Contrast Enhanced Thoracic Cone Beam CT Projections

    International Nuclear Information System (INIS)

    Purpose: To develop a novel technique to enhance the image contrast of clinical cone beam CT projections and extract respiratory signals based on anatomical motion using the modified Amsterdam Shroud (AS) method to benefit image guided radiation therapy. Methods: Thoracic cone beam CT projections acquired prior to treatment were preprocessed to increase their contrast for better respiratory signal extraction. Air intensity on raw images was firstly estimated and then applied to correct the projections to generate new attenuation images that were subsequently improved with deeper anatomy feature enhancement through taking logarithm operation, derivative along superior-inferior direction, respectively. All pixels on individual post-processed two dimensional images were horizontally summed to one column and all projections were combined side by side to create an AS image from which patient’s respiratory signal was extracted. The impact of gantry rotation on the breathing signal rendering was also investigated. Ten projection image sets from five lung cancer patients acquired with the Varian Onboard Imager on 21iX Clinac (Varian Medical Systems, Palo Alto, CA) were employed to assess the proposed technique. Results: Application of the air correction on raw projections showed that more than an order of magnitude of contrast enhancement was achievable. The typical contrast on the raw projections is around 0.02 while that on attenuation images could greater than 0.5. Clear and stable breathing signal can be reliably extracted from the new images while the uncorrected projection sets failed to yield clear signals most of the time. Conclusion: Anatomy feature plays a key role in yielding breathing signal from the projection images using the AS technique. The air correction process facilitated the contrast enhancement significantly and attenuation images thus obtained provides a practical solution to obtaining markerless breathing motion tracking

  3. Oahu Hyperspectral Imagery 2000 (207b-0613-332211) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  4. Oahu Hyperspectral Imagery 2000 (207a-0613-332211) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  5. 19 CFR 10.207 - Procedures for filing duty-free treatment claim and submitting supporting documentation.

    Science.gov (United States)

    2010-04-01

    ... directly to the port director, upon request, a declaration setting forth all pertinent detailed information concerning the production or manufacture of the article. When requested by the port director, the declaration... operations in the other beneficiary country or countries (including the Commonwealth of Puerto Rico, the...

  6. 33 CFR 207.380 - Red Lake River, Minn.; logging regulations for portion of river above Thief River Falls.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Red Lake River, Minn.; logging... Red Lake River, Minn.; logging regulations for portion of river above Thief River Falls. (a) Parties wishing to run logs on Red Lake River must provide storage booms near the head of the river to take...

  7. 24 CFR 207.252b - Premiums-mortgages insured pursuant to section 223(f) of the Act.

    Science.gov (United States)

    2010-04-01

    ... HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES MULTIFAMILY HOUSING MORTGAGE INSURANCE Contract Rights.... (a) The mortgagee, upon the initial-final endorsement of the mortgage for insurance pursuant to...

  8. A Review of the Evidence for Using Bedaquiline (TMC207) to Treat Multi-Drug Resistant Tuberculosis

    OpenAIRE

    Gregory J Fox; Menzies, Dick

    2013-01-01

    Existing therapies for multi-drug resistant tuberculosis (MDR-TB) have substantial limitations, in terms of their effectiveness, side-effect profile, and complexity of administration. Bedaquiline is a novel diarylquinoline antibiotic that has recently been investigated as an adjunct to existing therapies for MDR-TB. Currently, limited clinical data are available to evaluate the drug’s safety and effectiveness. In two small randomized-controlled clinical studies, bedaquiline given for 8 or 24 ...

  9. SU-D-207-01: Markerless Respiratory Motion Tracking with Contrast Enhanced Thoracic Cone Beam CT Projections

    Energy Technology Data Exchange (ETDEWEB)

    Chao, M; Yuan, Y; Rosenzweig, K; Lo, Y [The Mount Sinai Medical Center, New York, NY (United States); Brousmiche, S [Ion Beam Application, Louvain-la-neuve (Belgium)

    2015-06-15

    Purpose: To develop a novel technique to enhance the image contrast of clinical cone beam CT projections and extract respiratory signals based on anatomical motion using the modified Amsterdam Shroud (AS) method to benefit image guided radiation therapy. Methods: Thoracic cone beam CT projections acquired prior to treatment were preprocessed to increase their contrast for better respiratory signal extraction. Air intensity on raw images was firstly estimated and then applied to correct the projections to generate new attenuation images that were subsequently improved with deeper anatomy feature enhancement through taking logarithm operation, derivative along superior-inferior direction, respectively. All pixels on individual post-processed two dimensional images were horizontally summed to one column and all projections were combined side by side to create an AS image from which patient’s respiratory signal was extracted. The impact of gantry rotation on the breathing signal rendering was also investigated. Ten projection image sets from five lung cancer patients acquired with the Varian Onboard Imager on 21iX Clinac (Varian Medical Systems, Palo Alto, CA) were employed to assess the proposed technique. Results: Application of the air correction on raw projections showed that more than an order of magnitude of contrast enhancement was achievable. The typical contrast on the raw projections is around 0.02 while that on attenuation images could greater than 0.5. Clear and stable breathing signal can be reliably extracted from the new images while the uncorrected projection sets failed to yield clear signals most of the time. Conclusion: Anatomy feature plays a key role in yielding breathing signal from the projection images using the AS technique. The air correction process facilitated the contrast enhancement significantly and attenuation images thus obtained provides a practical solution to obtaining markerless breathing motion tracking.

  10. SU-E-J-207: Effect of Pulse Sequence Parameters On Geometric Distortions Induced by a Titanium Brachytherapy Applicator

    Energy Technology Data Exchange (ETDEWEB)

    Shea, S; Diak, A; Surucu, M; Harkenrider, M; Yacoub, J; Roeske, J; Small, W [Loyola University Chicago and Loyola University Medical Center, Maywood, IL (United States)

    2015-06-15

    Purpose: To investigate the effect of readout bandwidth and voxel size on the appearance of distortion artifacts caused by a titanium brachytherapy applicator. Methods: An acrylic phantom was constructed to rigidly hold a MR conditional, titanium Fletcher-Suit-Delclos-style applicator set (Varian Medical Systems) for imaging on CT (Philips Brilliance) and 1.5T MRI (Siemens Magnetom Aera). Several variants of MRI parameters were tried for 2D T2-weighted turbo spin echo imaging in comparison against the standard clinical protocol with the criteria to keep relative SNR loss less than 20% and imaging time as short as possible. Two 3D sequences were also used for comparison with similar parameters. The applicator tandem was segmented on axial CT images (0.4×0.4×1.5mm {sup 3} resolution) and the CT images were registered to the 3D MR images in Eclipse (Varian). The applicator volume was then overlaid on all MRI sets in 3D-Slicer and distances were measured from the tandem tip to the MRI artifact edge in right/left/superior and anterior/posterior/superior directions from coronal and sagittal 2D acquisitions, respectively, or 3D data reformats. Artifact regions were also manually contoured in coronal/sagittal orientations for area measurements. Results: As would be expected, reductions in voxel size and increases in readout bandwidth reduced artifact size (average max artifact length decreased by 0.95 mm and average max area decrease by 0.27 cm{sup 2}). Interestingly, bandwidth increases yielded reductions in area (0.19 cm{sup 2}) and in distance measurements (1 mm) even with voxel increases, as compared to a standard protocol. This could be useful when high performance protocols are not feasible due to long imaging times. Conclusion: We have characterized artifacts caused by cervical brachytherapy applicator across multiple sequence parameters at 1.5T. Future work will focus on finalizing an optimal protocol that balances artifact reduction with imaging time and then testing this new protocol in patients.

  11. SU-C-207-01: Four-Dimensional Inverse Geometry Computed Tomography: Concept and Its Validation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, K; Kim, D; Kim, T; Kang, S; Cho, M; Shin, D; Suh, T [The Catholic University of Korea, Seoul (Korea, Republic of)

    2015-06-15

    Purpose: In past few years, the inverse geometry computed tomography (IGCT) system has been developed to overcome shortcomings of a conventional computed tomography (CT) system such as scatter problem induced from large detector size and cone-beam artifact. In this study, we intend to present a concept of a four-dimensional (4D) IGCT system that has positive aspects above all with temporal resolution for dynamic studies and reduction of motion artifact. Methods: Contrary to conventional CT system, projection data at a certain angle in IGCT was a group of fractionated narrow cone-beam projection data, projection group (PG), acquired from multi-source array which have extremely short time gap of sequential operation between each of sources. At this, for 4D IGCT imaging, time-related data acquisition parameters were determined by combining multi-source scanning time for collecting one PG with conventional 4D CBCT data acquisition sequence. Over a gantry rotation, acquired PGs from multi-source array were tagged time and angle for 4D image reconstruction. Acquired PGs were sorted into 10 phase and image reconstructions were independently performed at each phase. Image reconstruction algorithm based upon filtered-backprojection was used in this study. Results: The 4D IGCT had uniform image without cone-beam artifact on the contrary to 4D CBCT image. In addition, the 4D IGCT images of each phase had no significant artifact induced from motion compared with 3D CT. Conclusion: The 4D IGCT image seems to give relatively accurate dynamic information of patient anatomy based on the results were more endurable than 3D CT about motion artifact. From this, it will be useful for dynamic study and respiratory-correlated radiation therapy. This work was supported by the Industrial R&D program of MOTIE/KEIT [10048997, Development of the core technology for integrated therapy devices based on real-time MRI guided tumor tracking] and the Mid-career Researcher Program (2014R1A2A1A10050270) through the National Research Foundation of Korea funded by the Ministry of Science, ICT&Future Planning.

  12. 33 CFR 207.680 - Willamette River, Oreg.; use, administration, and navigation of canal and locks at Willamette...

    Science.gov (United States)

    2010-07-01

    ... have aboard an adequate number of suitable fenders of timber, rubber, or rope which are to be placed... spring lines and such other lines as may be necessary to the fastenings provided for that purpose;...

  13. 33 CFR 207.160 - All waterways tributary to the Atlantic Ocean south of Chesapeake Bay and all waterways tributary...

    Science.gov (United States)

    2010-07-01

    ... contract lock operator except that the responsibility for enforcing all laws, rules and regulations shall... properly and securely assembled. The passage of “bag” or “sack” rafts, “dog” rafts, or of loose logs...

  14. 33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...

    Science.gov (United States)

    2010-07-01

    ... River to Chesapeake Bay, Del. and Md., between Reedy Point, Delaware River, and Old Town Point Wharf... located at Reedy Point and Old Town Point Wharf. These traffic lights are described in the rules...

  15. SU-E-J-207: Effect of Pulse Sequence Parameters On Geometric Distortions Induced by a Titanium Brachytherapy Applicator

    International Nuclear Information System (INIS)

    Purpose: To investigate the effect of readout bandwidth and voxel size on the appearance of distortion artifacts caused by a titanium brachytherapy applicator. Methods: An acrylic phantom was constructed to rigidly hold a MR conditional, titanium Fletcher-Suit-Delclos-style applicator set (Varian Medical Systems) for imaging on CT (Philips Brilliance) and 1.5T MRI (Siemens Magnetom Aera). Several variants of MRI parameters were tried for 2D T2-weighted turbo spin echo imaging in comparison against the standard clinical protocol with the criteria to keep relative SNR loss less than 20% and imaging time as short as possible. Two 3D sequences were also used for comparison with similar parameters. The applicator tandem was segmented on axial CT images (0.4×0.4×1.5mm 3 resolution) and the CT images were registered to the 3D MR images in Eclipse (Varian). The applicator volume was then overlaid on all MRI sets in 3D-Slicer and distances were measured from the tandem tip to the MRI artifact edge in right/left/superior and anterior/posterior/superior directions from coronal and sagittal 2D acquisitions, respectively, or 3D data reformats. Artifact regions were also manually contoured in coronal/sagittal orientations for area measurements. Results: As would be expected, reductions in voxel size and increases in readout bandwidth reduced artifact size (average max artifact length decreased by 0.95 mm and average max area decrease by 0.27 cm2). Interestingly, bandwidth increases yielded reductions in area (0.19 cm2) and in distance measurements (1 mm) even with voxel increases, as compared to a standard protocol. This could be useful when high performance protocols are not feasible due to long imaging times. Conclusion: We have characterized artifacts caused by cervical brachytherapy applicator across multiple sequence parameters at 1.5T. Future work will focus on finalizing an optimal protocol that balances artifact reduction with imaging time and then testing this new protocol in patients

  16. 33 CFR 207.590 - Black Rock Canal and Lock at Buffalo, N.Y.; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... collision between vessels in the restricted section of the canal. (m) Black Rock Lock. All vessels and boats... of the former's order of arrival. (5) All vessels and boats shall be maneuvered with great care so...

  17. 33 CFR 207.200 - Mississippi River below mouth of Ohio River, including South and Southwest Passes; use...

    Science.gov (United States)

    2010-07-01

    ... by United States. Except in case of great emergency, no vessel or craft shall anchor over revetted... Engineer by the most expeditious means available of all marine accidents, such as fire, collision,...

  18. Application of AMI 207A automatic welding to the erection engineering of electric instrument tube of nuclear powre plant

    International Nuclear Information System (INIS)

    The industrial application of automatic, intelligent and high-precision parameter-controlled welding equipment has become true long age in the western developed countries. However, this kind of equipment has been seldom used in China, especially on the erection site of nuclear power construction. In the Phase III of Qinshan Nuclear Power Project, we used the American AMI (Arc Machines, Inc.) 208A automatic welding equipment and technology to have all grooves of the electric instrument tubes automatically welded. The practice has proved that the automatic welding is more advanced, highly effective and more economic compared with other welding processes. (authors)

  19. 33 CFR 207.330 - Mississippi River between Winnibigoshish and Pokegama dams, Leech River between outlet of Leech...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Mississippi River between Winnibigoshish and Pokegama dams, Leech River between outlet of Leech Lake and Mississippi River, and Pokegama... Winnibigoshish and Pokegama dams, Leech River between outlet of Leech Lake and Mississippi River, and...

  20. 20 CFR 30.207 - How does a claimant prove a diagnosis of a beryllium disease covered under Part B?

    Science.gov (United States)

    2010-04-01

    ... this section), together with lung pathology consistent with chronic beryllium disease, including the...) Occupational or environmental history, or epidemiologic evidence of beryllium exposure; and (ii) Any three of...) Lung pathology consistent with chronic beryllium disease. (D) Clinical course consistent with a...

  1. Reconstructing classroom facilities to enhance communication in language learning. Case study: Classroom F207, JAMK Main campus

    OpenAIRE

    Nguyen, Thi Nhat Minh

    2015-01-01

    As an emerging movement, due to the influence of business globalisation, there is rarely any job offers without requirements in knowledge of foreign languages nowadays. Hence, foreign language education get lots of attention in order to improve, especially in education institute. The author, through years of studying foreign language at JAMK, has noticed the current JAMK language education’s situation. With major in Facility Management programme background, she hoped to enhance language learn...

  2. 33 CFR 207.275 - McClellan-Kerr Arkansas River navigation system: use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    .... If a towboat is not equipped with a radio or its radio is out of service, pilots shall furnish this... when navigation is passing over the dam. During daylight hours a yellow and black disc will be... deckhands shall maintain their stations while tows are moving adjacent to any part of a lock. They...

  3. 45 CFR 46.207 - Research not otherwise approvable which presents an opportunity to understand, prevent, or...

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Research not otherwise approvable which presents an opportunity to understand, prevent, or alleviate a serious problem affecting the health or welfare... which presents an opportunity to understand, prevent, or alleviate a serious problem affecting...

  4. Oahu Hyperspectral Imagery 2000 (207a-0613-272217) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  5. 5 CFR 2641.207 - One-year restriction on any former private sector assignee under the Information Technology...

    Science.gov (United States)

    2010-01-01

    ... private sector assignee under the Information Technology Exchange Program representing, aiding, counseling... assignee under the Information Technology Exchange Program representing, aiding, counseling or assisting in... the Information Technology Exchange Program, 5 U.S.C. chapter 37, no former assignee shall...

  6. 33 CFR 207.420 - Chicago River, Ill.; Sanitary District controlling works, and the use, administration, and...

    Science.gov (United States)

    2010-07-01

    ..., and by a traffic light showing a fixed red or fixed green light. The west end of the northwest gate block shall be marked by a traffic light showing a fixed red or fixed green light. The east end of the... standing near the ends of the lock guide walls. Signals from the lockmaster shall be by the traffic...

  7. WE-D-207-03: CT Protocols for Screening and the ACR Designated Lung Screening Program.

    OpenAIRE

    McNitt-Gray, M

    2015-01-01

    UNLABELLED: In the United States, Lung Cancer is responsible for more cancer deaths than the next four cancers combined. In addition, the 5 year survival rate for lung cancer patients has not improved over the past 40 to 50 years. To combat this deadly disease, in 2002 the National Cancer Institute launched a very large Randomized Control Trial called the National Lung Screening Trial (NLST). This trial would randomize subjects who had substantial risk of lung cancer (due to age and smoking h...

  8. SU-D-207-05: Real-Time Intrafractional Motion Tracking During VMAT Delivery Using a Conventional Elekta CBCT System

    International Nuclear Information System (INIS)

    Purpose: Real-time kV projection streaming capability has become recently available for Elekta XVI version 5.0. This study aims to investigate the feasibility and accuracy of real-time fiducial marker tracking during CBCT acquisition with or without simultaneous VMAT delivery using a conventional Elekta linear accelerator. Methods: A client computer was connected to an on-board kV imaging system computer, and receives and processes projection images immediately after image acquisition. In-house marker tracking software based on FFT normalized cross-correlation was developed and installed in the client computer. Three gold fiducial markers with 3 mm length were implanted in a pelvis-shaped phantom with 36 cm width. The phantom was placed on a programmable motion platform oscillating in anterior-posterior and superior-inferior directions simultaneously. The marker motion was tracked in real-time for (1) a kV-only CBCT scan with treatment beam off and (2) a kV CBCT scan during a 6-MV VMAT delivery. The exposure parameters per projection were 120 kVp and 1.6 mAs. Tracking accuracy was assessed by comparing superior-inferior positions between the programmed and tracked trajectories. Results: The projection images were successfully transferred to the client computer at a frequency of about 5 Hz. In the kV-only scan, highly accurate marker tracking was achieved over the entire range of cone-beam projection angles (detection rate / tracking error were 100.0% / 0.6±0.5 mm). In the kV-VMAT scan, MV-scatter degraded image quality, particularly for lateral projections passing through the thickest part of the phantom (kV source angle ranging 70°-110° and 250°-290°), resulting in a reduced detection rate (90.5%). If the lateral projections are excluded, tracking performance was comparable to the kV-only case (detection rate / tracking error were 100.0% / 0.8±0.5 mm). Conclusion: Our phantom study demonstrated a promising Result for real-time motion tracking using a conventional Elekta linear accelerator. MV-scatter suppression is needed to improve tracking accuracy during MV delivery. This research is funded by Motion Management Research Grant from Elekta

  9. First direct high-precision energy determination for the 8.4 and 20.7 keV nuclear transitions in Tm-169

    Czech Academy of Sciences Publication Activity Database

    Inoyatov, A. K.; Kovalík, Alojz; Filosofov, D. V.; Ryšavý, Miloš; Perevoshchikov, L. L.; Gurov, Yu. B.

    2015-01-01

    Roč. 51, č. 6 (2015), s. 65. ISSN 1434-6001 R&D Projects: GA MŠk LG14004; GA ČR(CZ) GAP203/12/1896 Institutional support: RVO:61389005 Keywords : electron binding energies * internal conversion * Tc-99M Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 2.736, year: 2014

  10. SU-D-207-03: Development of 4D-CBCT Imaging System with Dual Source KV X-Ray Tubes

    International Nuclear Information System (INIS)

    Purpose: The purposes of this work are to develop 4D-CBCT imaging system with orthogonal dual source kV X-ray tubes, and to determine the imaging doses from 4D-CBCT scans. Methods: Dual source kV X-ray tubes were used for the 4D-CBCT imaging. The maximum CBCT field of view was 200 mm in diameter and 150 mm in length, and the imaging parameters were 110 kV, 160 mA and 5 ms. The rotational angle was 105°, the rotational speed of the gantry was 1.5°/s, the gantry rotation time was 70 s, and the image acquisition interval was 0.3°. The observed amplitude of infrared marker motion during respiration was used to sort each image into eight respiratory phase bins. The EGSnrc/BEAMnrc and EGSnrc/DOSXYZnrc packages were used to simulate kV X-ray dose distributions of 4D-CBCT imaging. The kV X-ray dose distributions were calculated for 9 lung cancer patients based on the planning CT images with dose calculation grid size of 2.5 x 2.5 x 2.5 mm. The dose covering a 2-cc volume of skin (D2cc), defined as the inner 5 mm of the skin surface with the exception of bone structure, was assessed. Results: A moving object was well identified on 4D-CBCT images in a phantom study. Given a gantry rotational angle of 105° and the configuration of kV X-ray imaging subsystems, both kV X-ray fields overlapped at a part of skin surface. The D2cc for the 4D-CBCT scans was in the range 73.8–105.4 mGy. Linear correlation coefficient between the 1000 minus averaged SSD during CBCT scanning and D2cc was −0.65 (with a slope of −0.17) for the 4D-CBCT scans. Conclusion: We have developed 4D-CBCT imaging system with dual source kV X-ray tubes. The total imaging dose with 4D-CBCT scans was up to 105.4 mGy

  11. SU-D-207-07: Implementation of Full/half Bowtie Filter Model in a Commercial Treatment Planning System for Kilovoltage X-Ray Imaging Dose Estimation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, S [Advocate Lutheran General Hospital, Park Ridge, IL (United States); Alaei, P [Univ Minnesota, Minneapolis, MN (United States)

    2015-06-15

    Purpose: To implement full/half bowtie filter models in a commercial treatment planning system (TPS) to calculate kilovoltage (kV) x-ray imaging dose of Varian On-Board Imager (OBI) cone beam CT (CBCT) system. Methods: Full/half bowtie filters of Varian OBI were created as compensator models in Pinnacle TPS (version 9.6) using Matlab software (version 2011a). The profiles of both bowtie filters were acquired from the manufacturer, imported into the Matlab system and hard coded in binary file format. A Pinnacle script was written to import each bowtie filter data into a Pinnacle treatment plan as a compensator. A kV x-ray beam model without including the compensator model was commissioned per each bowtie filter setting based on percent depth dose and lateral profile data acquired from Monte Carlo simulations. To validate the bowtie filter models, a rectangular water phantom was generated in the planning system and an anterior/posterior beam with each bowtie filter was created. Using the Pinnacle script, each bowtie filter compensator was added to the treatment plan. Lateral profile at the depth of 3cm and percent depth dose were measured using an ion chamber and compared with the data extracted from the treatment plans. Results: The kV x-ray beams for both full and half bowtie filter have been modeled in a commercial TPS. The difference of lateral and depth dose profiles between dose calculations and ion chamber measurements were within 6%. Conclusion: Both full/half bowtie filter models provide reasonable results in kV x-ray dose calculations in the water phantom. This study demonstrates the possibility of using a model-based treatment planning system to calculate the kV imaging dose for both full and half bowtie filter modes. Further study is to be performed to evaluate the models in clinical situations.

  12. SU-C-207-05: A Comparative Study of Noise-Reduction Algorithms for Low-Dose Cone-Beam Computed Tomography

    International Nuclear Information System (INIS)

    Purpose: To study different noise-reduction algorithms and to improve the image quality of low dose cone beam CT for patient positioning in radiation therapy. Methods: In low-dose cone-beam CT, the reconstructed image is contaminated with excessive quantum noise. In this study, three well-developed noise reduction algorithms namely, a) penalized weighted least square (PWLS) method, b) split-Bregman total variation (TV) method, and c) compressed sensing (CS) method were studied and applied to the images of a computer–simulated “Shepp-Logan” phantom and a physical CATPHAN phantom. Up to 20% additive Gaussian noise was added to the Shepp-Logan phantom. The CATPHAN phantom was scanned by a Varian OBI system with 100 kVp, 4 ms and 20 mA. For comparing the performance of these algorithms, peak signal-to-noise ratio (PSNR) of the denoised images was computed. Results: The algorithms were shown to have the potential in reducing the noise level for low-dose CBCT images. For Shepp-Logan phantom, an improvement of PSNR of 2 dB, 3.1 dB and 4 dB was observed using PWLS, TV and CS respectively, while for CATPHAN, the improvement was 1.2 dB, 1.8 dB and 2.1 dB, respectively. Conclusion: Penalized weighted least square, total variation and compressed sensing methods were studied and compared for reducing the noise on a simulated phantom and a physical phantom scanned by low-dose CBCT. The techniques have shown promising results for noise reduction in terms of PSNR improvement. However, reducing the noise without compromising the smoothness and resolution of the image needs more extensive research

  13. UGT2B17 genotype and the pharmacokinetic serum profile of Testosterone during substitution therapy with Testosterone Undecanoate. A retrospective experience from 207 men with hypogonadism.

    OpenAIRE

    Anne Kirstine eBang; Niels eJørgensen; Ewa eRajpert-De Meyts; Anders eJuul

    2013-01-01

    BackgroundTestosterone (T) is mainly excreted in the urine as testosterone glucuronide (TG). This glucuronidation is partly dependent on the UGT2B17 genotype, and TG excretion is therefore lower in men having the UGT2B17 deletion. However, the possible influence of UGT2B17 genotype on serum T during androgen therapy is unknown. We retrospectively investigated the possible association between the UGT2B17 gene polymorphism and serum T levels in hypogonadal men during Testosterone undecanoate (T...

  14. UGT2B17 Genotype and the Pharmacokinetic Serum Profile of Testosterone during Substitution Therapy with Testosterone Undecanoate. A Retrospective Experience from 207 Men with Hypogonadism

    OpenAIRE

    Bang, Anne Kirstine; Jørgensen, Niels; Rajpert-De Meyts, Ewa; Juul, Anders

    2013-01-01

    Background: Testosterone (T) is mainly excreted in the urine as testosterone glucuronide (TG). This glucuronidation is partly dependent on the UGT2B17 genotype, and TG excretion is therefore lower in men having the UGT2B17 deletion. However, the possible influence of UGT2B17 genotype on serum T during androgen therapy is unknown. We retrospectively investigated the possible association between the UGT2B17 gene polymorphism and serum T levels in hypogonadal men during Testosterone undecanoate ...

  15. Randomized Dose-Ranging Study of the 14-Day Early Bactericidal Activity of Bedaquiline (TMC207) in Patients with Sputum Microscopy Smear-Positive Pulmonary Tuberculosis

    OpenAIRE

    Diacon, Andreas H; Dawson, Rodney; Von Groote-Bidlingmaier, Florian; Symons, Gregory; Venter, Amour; Donald, Peter R.; Conradie, Almari; Erondu, Ngozi; Ginsberg, Ann M.; Egizi, Erica; Winter, Helen; De Becker, Piet; Mendel, Carl M.

    2013-01-01

    Bedaquiline is a new antituberculosis agent targeting ATP synthase. This randomized, double-blinded study enrolling 68 sputum smear-positive pulmonary tuberculosis patients evaluated the 14-day early bactericidal activity of daily doses of 100 mg, 200 mg, 300 mg, and 400 mg bedaquiline, preceded by loading doses of 200 mg, 400 mg, 500 mg, and 700 mg, respectively, on the first treatment day and 100 mg, 300 mg, 400 mg, and 500 mg on the second treatment day. All groups showed activity with a m...

  16. SU-D-207-06: Clinical Validations of Shading Correction for Cone-Beam CT Using Planning CT as a Prior

    International Nuclear Information System (INIS)

    Purpose: Current cone-beam CT (CBCT) images contain severe shading artifacts mainly due to scatter, hindering their quantitative use in current radiation therapy. We have previously proposed an effective shading correction method for CBCT using planning CT (pCT) as prior knowledge. In this work, we investigate the method robustness via statistical analyses on studies of a large patient group and compare the performance with that of a state-of-the-art method implemented on the current commercial radiation therapy machine -- the Varian Truebeam system. Methods: Since radiotherapy patients routinely undergo multiple-detector CT (MDCT) scans in the planning procedure, we use the high-quality pCT as “free” prior knowledge for CBCT image improvement. The CBCT image with no correction is first spatially registered with the pCT. Primary CBCT projections are estimated via forward projections of the registered image. The low frequency errors in the projections, which stem from mainly scatter, are estimated by filtering the difference between original line integral and the estimated scatter projections. The corrected CBCT image is then reconstructed from the scatter corrected projections. The proposed method is evaluated on 40 cancer patients. Results: On all patient images, we compare errors on CT number, spatial non-uniformity (SNU) and image contrast, using pCT as the ground truth. T-tests show that our algorithm improves over the Varian method on CBCT accuracies of CT number and SNU with 90% confident. The average CT number error is reduced from 54.8 HU on the Varian method to 40.9 HU, and the SNU error is reduced from 7.7% to 3.8%. There is no obvious improvement on image contrast. Conclusion: Large-group patient studies show that the proposed pCT-based algorithm outperforms the Varian method of the Truebeam system on CBCT shading correction, by providing CBCT images with higher CT number accuracy and greater image uniformity

  17. SU-C-207-04: Reconstruction Artifact Reduction in X-Ray Cone Beam CT Using a Treatment Couch Model

    Energy Technology Data Exchange (ETDEWEB)

    Lasio, G; Hu, E; Zhou, J; Lee, M; Yi, B [University of Maryland School of Medicine, Baltimore, MD (United States)

    2015-06-15

    Purpose: to mitigate artifacts induced by the presence of the RT treatment couch in on-board CBCT and improve image quality Methods: a model of a Varian IGRT couch is constructed using a CBCT scan of the couch in air. The model is used to generate a set of forward projections (FP) of the treatment couch at specified gantry angles. The model couch forward projections are then used to process CBCT scan projections which contain the couch in addition to the scan object (Catphan phantom), in order to remove the attenuation component of the couch at any given gantry angle. Prior to pre-processing with the model FP, the Catphan projection data is normalized to an air scan with bowtie filter. The filtered Catphan projections are used to reconstruct the CBCT with an in-house FDK algorithm. The artifact reduction in the processed CBCT scan is assessed visually, and the image quality improvement is measured with the CNR over a few selected ROIs of the Catphan modules. Results: Sufficient match between the forward projected data and the x-ray projections is achieved to allow filtering in attenuation space. Visual improvement of the couch induced artifacts is achieved, with a moderate expense of CNR. Conclusion: Couch model-based correction of CBCT projection data has a potential for qualitative improvement of clinical CBCT scans, without requiring position specific correction data. The technique could be used to produce models of other artifact inducing devices, such as immobilization boards, and reduce their impact on patient CBCT images.

  18. SU-D-207-06: Clinical Validations of Shading Correction for Cone-Beam CT Using Planning CT as a Prior

    Energy Technology Data Exchange (ETDEWEB)

    Tsui, T; Zhu, L [Georgia Institute of Technology, Atlanta, GA (Georgia); Wei, J [Landauer Medical Physics, Newnan, GA (United States)

    2015-06-15

    Purpose: Current cone-beam CT (CBCT) images contain severe shading artifacts mainly due to scatter, hindering their quantitative use in current radiation therapy. We have previously proposed an effective shading correction method for CBCT using planning CT (pCT) as prior knowledge. In this work, we investigate the method robustness via statistical analyses on studies of a large patient group and compare the performance with that of a state-of-the-art method implemented on the current commercial radiation therapy machine -- the Varian Truebeam system. Methods: Since radiotherapy patients routinely undergo multiple-detector CT (MDCT) scans in the planning procedure, we use the high-quality pCT as “free” prior knowledge for CBCT image improvement. The CBCT image with no correction is first spatially registered with the pCT. Primary CBCT projections are estimated via forward projections of the registered image. The low frequency errors in the projections, which stem from mainly scatter, are estimated by filtering the difference between original line integral and the estimated scatter projections. The corrected CBCT image is then reconstructed from the scatter corrected projections. The proposed method is evaluated on 40 cancer patients. Results: On all patient images, we compare errors on CT number, spatial non-uniformity (SNU) and image contrast, using pCT as the ground truth. T-tests show that our algorithm improves over the Varian method on CBCT accuracies of CT number and SNU with 90% confident. The average CT number error is reduced from 54.8 HU on the Varian method to 40.9 HU, and the SNU error is reduced from 7.7% to 3.8%. There is no obvious improvement on image contrast. Conclusion: Large-group patient studies show that the proposed pCT-based algorithm outperforms the Varian method of the Truebeam system on CBCT shading correction, by providing CBCT images with higher CT number accuracy and greater image uniformity.

  19. SU-D-207-05: Real-Time Intrafractional Motion Tracking During VMAT Delivery Using a Conventional Elekta CBCT System

    Energy Technology Data Exchange (ETDEWEB)

    Park, Yang-Kyun; Sharp, Gregory C.; Gierga, David P.; Winey, Brian A. [Massachusetts General Hospital, Boston, MA (United States); Ye, Sung-Joon [Seoul National University, Seoul (Korea, Republic of)

    2015-06-15

    Purpose: Real-time kV projection streaming capability has become recently available for Elekta XVI version 5.0. This study aims to investigate the feasibility and accuracy of real-time fiducial marker tracking during CBCT acquisition with or without simultaneous VMAT delivery using a conventional Elekta linear accelerator. Methods: A client computer was connected to an on-board kV imaging system computer, and receives and processes projection images immediately after image acquisition. In-house marker tracking software based on FFT normalized cross-correlation was developed and installed in the client computer. Three gold fiducial markers with 3 mm length were implanted in a pelvis-shaped phantom with 36 cm width. The phantom was placed on a programmable motion platform oscillating in anterior-posterior and superior-inferior directions simultaneously. The marker motion was tracked in real-time for (1) a kV-only CBCT scan with treatment beam off and (2) a kV CBCT scan during a 6-MV VMAT delivery. The exposure parameters per projection were 120 kVp and 1.6 mAs. Tracking accuracy was assessed by comparing superior-inferior positions between the programmed and tracked trajectories. Results: The projection images were successfully transferred to the client computer at a frequency of about 5 Hz. In the kV-only scan, highly accurate marker tracking was achieved over the entire range of cone-beam projection angles (detection rate / tracking error were 100.0% / 0.6±0.5 mm). In the kV-VMAT scan, MV-scatter degraded image quality, particularly for lateral projections passing through the thickest part of the phantom (kV source angle ranging 70°-110° and 250°-290°), resulting in a reduced detection rate (90.5%). If the lateral projections are excluded, tracking performance was comparable to the kV-only case (detection rate / tracking error were 100.0% / 0.8±0.5 mm). Conclusion: Our phantom study demonstrated a promising Result for real-time motion tracking using a conventional Elekta linear accelerator. MV-scatter suppression is needed to improve tracking accuracy during MV delivery. This research is funded by Motion Management Research Grant from Elekta.

  20. SU-C-207-02: A Method to Estimate the Average Planar Dose From a C-Arm CBCT Acquisition

    Energy Technology Data Exchange (ETDEWEB)

    Supanich, MP [Rush University Medical Center, Chicago, IL (United States)

    2015-06-15

    Purpose: The planar average dose in a C-arm Cone Beam CT (CBCT) acquisition had been estimated in the past by averaging the four peripheral dose measurements in a CTDI phantom and then using the standard 2/3rds peripheral and 1/3 central CTDIw method (hereafter referred to as Dw). The accuracy of this assumption has not been investigated and the purpose of this work is to test the presumed relationship. Methods: Dose measurements were made in the central plane of two consecutively placed 16cm CTDI phantoms using a 0.6cc ionization chamber at each of the 4 peripheral dose bores and in the central dose bore for a C-arm CBCT protocol. The same setup was scanned with a circular cut-out of radiosensitive gafchromic film positioned between the two phantoms to capture the planar dose distribution. Calibration curves for color pixel value after scanning were generated from film strips irradiated at different known dose levels. The planar average dose for red and green pixel values was calculated by summing the dose values in the irradiated circular film cut out. Dw was calculated using the ionization chamber measurements and film dose values at the location of each of the dose bores. Results: The planar average dose using both the red and green pixel color calibration curves were within 10% agreement of the planar average dose estimated using the Dw method of film dose values at the bore locations. Additionally, an average of the planar average doses calculated using the red and green calibration curves differed from the ionization chamber Dw estimate by only 5%. Conclusion: The method of calculating the planar average dose at the central plane of a C-arm CBCT non-360 rotation by calculating Dw from peripheral and central dose bore measurements is a reasonable approach to estimating the planar average dose. Research Grant, Siemens AG.

  1. CENER/NREL Collaboration in Testing Facility and Code Development: Cooperative Research and Development Final Report, CRADA Number CRD-06-207

    Energy Technology Data Exchange (ETDEWEB)

    Moriarty, P.

    2014-11-01

    Under the funds-in CRADA agreement, NREL and CENER will collaborate in the areas of blade and drivetrain testing facility development and code development. The project shall include NREL assisting in the review and instruction necessary to assist in commissioning the new CENER blade test and drivetrain test facilities. In addition, training will be provided by allowing CENER testing staff to observe testing and operating procedures at the NREL blade test and drivetrain test facilities. CENER and NREL will exchange blade and drivetrain facility and equipment design and performance information. The project shall also include exchanging expertise in code development and data to validate numerous computational codes.

  2. 206/207Pb and Radiocarbon: An Unlikely Pair for Identifying the Source and Delivery Time of Ocean Advection in the South China Sea

    Science.gov (United States)

    Switzer, A.; Goodkin, N.; Bolton, A.; Chen, M.; Druffel, E. R. M.; Boyle, E. A.

    2015-12-01

    Two independent studies were undertaken to use anthropogenic emissions to investigate natural systems using a massive Porites coral taken from off the coast of Vietnam (12ο12'49.90"N, 109 ο18'17.51"E). Annual uptake of bomb radiocarbon (14CO2) was measured to investigate the impact of coastal upwelling; while Pb/Ca levels and Pb isotopes were measured to investigate oceanic infiltration of anthropogenic Pb. Both records reveal a signal of sub-surface seawater advection from the tropical North Pacific to the South China Sea (SCS) providing independent evidence for the source and delivery time of the upwelled water off the coast of Vietnam. The radiocarbon record, extending from 1900-1986 at ~annual resolution, shows a post-bomb peak lower and broader than those found from other corals in the SCS and Japan, but higher than those found in the Makassar Strait in Indonesia. The Makassar coral experiences three water masses: the South Equatorial Current (SEC), upwelled and SCS water. The SEC has a relatively low radiocarbon content. However, water in the SCS does not mix with SEC water that enters the Indonesia Seas via the Halmahera as the main throughflow is from north to south. Hence, the upwelling signature must be from the North Equatorial Current that enters from the Luzon strait at depth. Leaded gasoline was phased-out between 1997 and 2000 in most Asian countries, however unlike other regional records, the Pb/Ca of the coral continued to increase until 2004 indicating a non-atmospheric source of Pb to the region. Both records indicate the source of upwelled water from the tropical North Pacific at roughly ~100-200 meters with a transport time of >2-5 years. This water is carried westward, via the Luzon Strait and into the South China Sea, where is it upwelled during the summer months. A higher resolution study of this coral combined with other coral records from the region could further narrow the location and timing of the advection and upwelling.

  3. SU-C-207-02: A Method to Estimate the Average Planar Dose From a C-Arm CBCT Acquisition

    International Nuclear Information System (INIS)

    Purpose: The planar average dose in a C-arm Cone Beam CT (CBCT) acquisition had been estimated in the past by averaging the four peripheral dose measurements in a CTDI phantom and then using the standard 2/3rds peripheral and 1/3 central CTDIw method (hereafter referred to as Dw). The accuracy of this assumption has not been investigated and the purpose of this work is to test the presumed relationship. Methods: Dose measurements were made in the central plane of two consecutively placed 16cm CTDI phantoms using a 0.6cc ionization chamber at each of the 4 peripheral dose bores and in the central dose bore for a C-arm CBCT protocol. The same setup was scanned with a circular cut-out of radiosensitive gafchromic film positioned between the two phantoms to capture the planar dose distribution. Calibration curves for color pixel value after scanning were generated from film strips irradiated at different known dose levels. The planar average dose for red and green pixel values was calculated by summing the dose values in the irradiated circular film cut out. Dw was calculated using the ionization chamber measurements and film dose values at the location of each of the dose bores. Results: The planar average dose using both the red and green pixel color calibration curves were within 10% agreement of the planar average dose estimated using the Dw method of film dose values at the bore locations. Additionally, an average of the planar average doses calculated using the red and green calibration curves differed from the ionization chamber Dw estimate by only 5%. Conclusion: The method of calculating the planar average dose at the central plane of a C-arm CBCT non-360 rotation by calculating Dw from peripheral and central dose bore measurements is a reasonable approach to estimating the planar average dose. Research Grant, Siemens AG

  4. Non-Destructive Assessment of Concrete Structures Reliability and Limits of Single and Combined Techniques State-of-the-Art Report of the RILEM Technical Committee 207-INR

    CERN Document Server

    2012-01-01

    This book gives information on non destructive techniques for assessment of concrete structures. It synthesizes the best of international knowledge about what techniques can be used for assessing material properties (strength) and structural properties (geometry, defects...). It describes how the techniques can be used so as to answer a series of usual questions, highlighting their capabilities and limits, and providing advices for a better use of techniques. It also focuses on possible combinations of techniques so as to improve the assessment. It is based on many illustrative examples and give in each case references to standards and guidelines.

  5. SU-D-207-03: Development of 4D-CBCT Imaging System with Dual Source KV X-Ray Tubes

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, M; Ishihara, Y; Matsuo, Y; Ueki, N; Iizuka, Y; Mizowaki, T; Hiraoka, M [Kyoto University Hospital, Kyoto, Kyoto (Japan)

    2015-06-15

    Purpose: The purposes of this work are to develop 4D-CBCT imaging system with orthogonal dual source kV X-ray tubes, and to determine the imaging doses from 4D-CBCT scans. Methods: Dual source kV X-ray tubes were used for the 4D-CBCT imaging. The maximum CBCT field of view was 200 mm in diameter and 150 mm in length, and the imaging parameters were 110 kV, 160 mA and 5 ms. The rotational angle was 105°, the rotational speed of the gantry was 1.5°/s, the gantry rotation time was 70 s, and the image acquisition interval was 0.3°. The observed amplitude of infrared marker motion during respiration was used to sort each image into eight respiratory phase bins. The EGSnrc/BEAMnrc and EGSnrc/DOSXYZnrc packages were used to simulate kV X-ray dose distributions of 4D-CBCT imaging. The kV X-ray dose distributions were calculated for 9 lung cancer patients based on the planning CT images with dose calculation grid size of 2.5 x 2.5 x 2.5 mm. The dose covering a 2-cc volume of skin (D2cc), defined as the inner 5 mm of the skin surface with the exception of bone structure, was assessed. Results: A moving object was well identified on 4D-CBCT images in a phantom study. Given a gantry rotational angle of 105° and the configuration of kV X-ray imaging subsystems, both kV X-ray fields overlapped at a part of skin surface. The D2cc for the 4D-CBCT scans was in the range 73.8–105.4 mGy. Linear correlation coefficient between the 1000 minus averaged SSD during CBCT scanning and D2cc was −0.65 (with a slope of −0.17) for the 4D-CBCT scans. Conclusion: We have developed 4D-CBCT imaging system with dual source kV X-ray tubes. The total imaging dose with 4D-CBCT scans was up to 105.4 mGy.

  6. SU-C-207-07: Quantification of Coronary Artery Cross-Sectional Area in CT Angiography Using Integrated Density: A Phantom Study

    International Nuclear Information System (INIS)

    Purpose: To investigate the feasibility of quantifying the cross-sectional area (CSA) of coronary arteries using integrated density in a physics-based model with a phantom study. Methods: In this technique the total integrated density of the object as compared with its local background is measured so it is possible to account for the partial volume effect. The proposed method was compared to manual segmentation using CT scans of a 10 cm diameter Lucite cylinder placed inside a chest phantom. Holes with cross-sectional areas from 1.4 to 12.3 mm2 were drilled into the Lucite and filled with iodine solution, producing a contrast-to-noise ratio of approximately 26. Lucite rods 1.6 mm in diameter were used to simulate plaques. The phantom was imaged with and without the Lucite rods placed in the holes to simulate diseased and normal arteries, respectively. Linear regression analysis was used, and the root-mean-square deviations (RMSD) and errors (RMSE) were computed to assess the precision and accuracy of the measurements. In the case of manual segmentation, two readers independently delineated the lumen in order to quantify the inter-reader variability. Results: The precision and accuracy for the normal vessels using the integrated density technique were 0.32 mm2 and 0.32 mm2, respectively. The corresponding results for the manual segmentation were 0.51 mm2 and 0.56 mm2. In the case of diseased vessels, the precision and accuracy of the integrated density technique were 0.46 mm2 and 0.55 mm2, respectively. The corresponding results for the manual segmentation were 0.75 mm2 and 0.98 mm2. The mean percent difference for the two readers was found to be 8.4%. Conclusion: The CSA based on integrated density had improved precision and accuracy as compared with manual segmentation in a Lucite phantom. The results indicate the potential for using integrated density to improve CSA measurements in CT angiography

  7. Sustainable Leadership: Leadership from the Heart. By Steen Hildebrandt and Michael Stubberup, Copenhagen Press, 2012; 280 Pages. Price $29.99, ISBN 978-87-7853-207-7

    OpenAIRE

    Shu-Kun Lin

    2013-01-01

    We must develop a serious approach to the fact that emotions, thoughts, assessments, and decisions originate in the mind, and as such are firmly based in human beings. We sense, experience, and act on the basis of internal processes, but which criteria constitute the basis of these processes and how does the internal “control system”, which we all have, function? Moreover, we need to take a closer look at the ways in which the organic and sustainable mechanisms of our living organisms are opt...

  8. SU-C-207-06: In Vivo Quantification of Gold Nanoparticles Using K-Edge Imaging Via Spectrum Shaping by Gold Filter

    International Nuclear Information System (INIS)

    Purpose: Gold nanoparticles (AuNP) are multifunctional platforms ideal for drug delivery, targeted imaging and radiosensitization. We have investigated quantitative imaging of AuNPs using on board imager (OBI) cone beam computed tomography (CBCT). To this end, we also present, for the first time, a novel method for k-edge imaging of AuNP by filter-based spectral shaping. Methods: We used a digital 25 cm diameter water phantom, embedded with 3 cm spheres filled with AuNPs of different concentrations (0 mg/ml – 16 mg/ml). A poly-energetic X-ray spectrum of 140 kVp from a conventional X-ray tube is shaped by balanced K-edge filters to create an excess of photons right above the K-edge of gold at 80.7 keV. The filters consist of gold, tin, copper and aluminum foils. The phantom with appropriately assigned attenuation coefficients is forward projected onto a detector for each energy bin and then integrated. FKD reconstruction is performed on the integrated projections. Scatter, detector efficiency and noise are included. Results: We found that subtracting the results of two filter sets (Filter A:127 µm gold foil with 254 µm tin, 330 µm copper and 1 mm aluminum, and Filter B: 635 µm tin with 264 µm copper and 1 mm aluminum), provides substantial image contrast. The resulting filtered spectra match well below 80.7 keV, while maintaining sufficient X-ray quanta just above that. Voxel intensities of AuNP containing spheres increase linearly with AuNP concentration. K-edge imaging provides 18% more sensitivity than the tin filter alone, and 38% more sensitivity than the gold filter alone. Conclusion: We have shown that it is feasible to quantitatively detect AuNP distributions in a patient-sized phantom using clinical CBCT and K-edge spectral shaping

  9. SU-C-207-05: A Comparative Study of Noise-Reduction Algorithms for Low-Dose Cone-Beam Computed Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Mukherjee, S; Yao, W [St. Jude Children’s Research Hospital, Memphis, TN (United States)

    2015-06-15

    Purpose: To study different noise-reduction algorithms and to improve the image quality of low dose cone beam CT for patient positioning in radiation therapy. Methods: In low-dose cone-beam CT, the reconstructed image is contaminated with excessive quantum noise. In this study, three well-developed noise reduction algorithms namely, a) penalized weighted least square (PWLS) method, b) split-Bregman total variation (TV) method, and c) compressed sensing (CS) method were studied and applied to the images of a computer–simulated “Shepp-Logan” phantom and a physical CATPHAN phantom. Up to 20% additive Gaussian noise was added to the Shepp-Logan phantom. The CATPHAN phantom was scanned by a Varian OBI system with 100 kVp, 4 ms and 20 mA. For comparing the performance of these algorithms, peak signal-to-noise ratio (PSNR) of the denoised images was computed. Results: The algorithms were shown to have the potential in reducing the noise level for low-dose CBCT images. For Shepp-Logan phantom, an improvement of PSNR of 2 dB, 3.1 dB and 4 dB was observed using PWLS, TV and CS respectively, while for CATPHAN, the improvement was 1.2 dB, 1.8 dB and 2.1 dB, respectively. Conclusion: Penalized weighted least square, total variation and compressed sensing methods were studied and compared for reducing the noise on a simulated phantom and a physical phantom scanned by low-dose CBCT. The techniques have shown promising results for noise reduction in terms of PSNR improvement. However, reducing the noise without compromising the smoothness and resolution of the image needs more extensive research.

  10. 33 CFR 207.249 - Ouachita and Black Rivers, Ark. and La., Mile 0.0 to Mile 338.0 (Camden, Ark.) above the mouth of...

    Science.gov (United States)

    2010-07-01

    ... other lockages, then separate lockages shall be made. Dangerous cargoes are described in 46 CFR part 146.... and La., Mile 0.0 to Mile 338.0 (Camden, Ark.) above the mouth of the Black River; the Red River, La.... and La., Mile 0.0 to Mile 338.0 (Camden, Ark.) above the mouth of the Black River; the Red River,...

  11. SU-D-207-07: Implementation of Full/half Bowtie Filter Model in a Commercial Treatment Planning System for Kilovoltage X-Ray Imaging Dose Estimation

    International Nuclear Information System (INIS)

    Purpose: To implement full/half bowtie filter models in a commercial treatment planning system (TPS) to calculate kilovoltage (kV) x-ray imaging dose of Varian On-Board Imager (OBI) cone beam CT (CBCT) system. Methods: Full/half bowtie filters of Varian OBI were created as compensator models in Pinnacle TPS (version 9.6) using Matlab software (version 2011a). The profiles of both bowtie filters were acquired from the manufacturer, imported into the Matlab system and hard coded in binary file format. A Pinnacle script was written to import each bowtie filter data into a Pinnacle treatment plan as a compensator. A kV x-ray beam model without including the compensator model was commissioned per each bowtie filter setting based on percent depth dose and lateral profile data acquired from Monte Carlo simulations. To validate the bowtie filter models, a rectangular water phantom was generated in the planning system and an anterior/posterior beam with each bowtie filter was created. Using the Pinnacle script, each bowtie filter compensator was added to the treatment plan. Lateral profile at the depth of 3cm and percent depth dose were measured using an ion chamber and compared with the data extracted from the treatment plans. Results: The kV x-ray beams for both full and half bowtie filter have been modeled in a commercial TPS. The difference of lateral and depth dose profiles between dose calculations and ion chamber measurements were within 6%. Conclusion: Both full/half bowtie filter models provide reasonable results in kV x-ray dose calculations in the water phantom. This study demonstrates the possibility of using a model-based treatment planning system to calculate the kV imaging dose for both full and half bowtie filter modes. Further study is to be performed to evaluate the models in clinical situations

  12. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity ...

  13. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1995-12-01

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

  14. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    International Nuclear Information System (INIS)

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons

  15. Separation of 211At from irradiated bismuth target and labelling of a model protein

    International Nuclear Information System (INIS)

    Astatine-211 is a promising radionuclide for therapeutic use in nuclear medicine. An efficient method (70%) for radiochemical separation from the irradiated Bi-target has been described. The level of Bi contamination in the purified 2'11At-solution was estimated. Finally labelling of a model protein has been tried. (author). 14 refs

  16. Semente residual do urucum na alimentação de poedeiras comerciais: desempenho e características dos ovos - DOI: 10.4025/actascianimsci.v29i2.207 Annato seed byproduct used as a source of pigment in laying hen diets - DOI: 10.4025/actascianimsci.v29i2.207

    Directory of Open Access Journals (Sweden)

    Rafaele Ferreira Moreira

    2007-11-01

    Full Text Available O experimento foi conduzido para avaliar o efeito da inclusão da semente residual de urucum (SRU sobre o desempenho e qualidade dos ovos de poedeiras comerciais alimentadas com rações contendo sorgo. Cento e quarenta e quatro poedeiras comerciais foram distribuídas em um delineamento inteiramente ao acaso com seis tratamentos e seis repetições de quatro aves. Os tratamentos consistiram em uma ração � base de milho e, as demais, � base de sorgo com a inclusão de 0,0; 0,5; 1,0;1,5 e 2,0% de SRU. As variáveis: consumo de ração, percentagem de postura, peso e massa de ovo, conversão alimentar, percentagem de gema, albúmem e casca e unidades Haugh não foram afetadas significativamente pelos níveis de inclusão de SRU. Entretanto, a pigmentação da gema aumentou linearmente com o aumento de SRU na ração. A inclusão de 2% de SRU em rações contendo sorgo foi capaz de pigmentar as gemas em, aproximadamente, 61,4% da pigmentação obtida em rações compostas por milho.This experiment was conducted to evaluate the effect of inclusion of annatto (Bixa orellana L. seed byproduct (ASB in diets with sorghum on laying hens performance and eggs characteristics. A hundred and forty-four laying hens were randomly allotted to six treatments and six replications with four birds each. Treatments consisted of one diet based on corn and the five others based on sorghum with the inclusion of 0.0; 0.5; 1.0; 1.5 and 2.0% of ASB. Feed intake, egg production, egg weight, egg mass, feed conversion, yolk, albumen and shell percentages and Haugh units were not affected by the inclusion levels of ASB. However, yolk colour increased linearly as ASB increased in diet. The inclusion of 2% of annatto seed byproduct on laying hens diets based on sorghum improves egg yolk colour nearly 61.4% of that obtained with birds fed diet based on yellow corn.

  17. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  18. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  19. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  20. UGT2B17 genotype and the pharmacokinetic serum profile of testosterone during substitution therapy with testosterone undecanoate. A retrospective experience from 207 men with hypogonadism

    DEFF Research Database (Denmark)

    Bang, Anne Kirstine; Jørgensen, Niels; Rajpert-De Meyts, Ewa;

    2013-01-01

    during androgen therapy is unknown. We retrospectively investigated the possible association between the UGT2B17 gene polymorphism and serum T levels in hypogonadal men during Testosterone undecanoate (TU) substitution therapy. Subjects and Methods: Two hundred and seven patients treated with TU (Nebido......Background: Testosterone (T) is mainly excreted in the urine as testosterone glucuronide (TG). This glucuronidation is partly dependent on the UGT2B17 genotype, and TG excretion is therefore lower in men having the UGT2B17 deletion. However, the possible influence of UGT2B17 genotype on serum T...

  1. Precambrian crustal evolution and Cretaceous–Palaeogene faulting in West Greenland: 207Pb-206Pb dating of magnetite, monazite and allanite in the central and northern Nagssugtoqidian orogen, West Greenland

    Directory of Open Access Journals (Sweden)

    Frei, Robert

    2006-12-01

    Full Text Available Pb-isotopic data for magnetite from amphibolites in the Nagssugtoqidian orogen, central West Greenland, have been used to trace their source characteristics and the timing of metamorphism. Analyses of the magnetite define a Pb-Pb isochron age of 1726 ± 7 Ma. The magnetite is metamorphic in origin, and the 1726 Ma age is interpreted as a cooling age through the closing temperature of magnetite at ~600°C. Some of the amphibolites in this study come from the Naternaq supracrustal rocks in the northern Nagssugtoqidian orogen, which host the Naternaq sulphide deposit and may be part ofthe Nordre Strømfjord supracrustal suite, which was deposited at around 1950 Ma ago.Pb-isotopic signatures of magnetite from the Arfersiorfik quartz diorite in the central Nagssugtoqidian orogen are compatible with published whole-rock Pb-isotopic data from this suite; previous work has shown that it is a product of subduction-related calc-alkaline magmatism between 1920 and 1870 Ma. Intrusion of pegmatites occurred at around 1800 Ma in both the central and the northernparts of the orogen. Pegmatite ages have been determined by Pb stepwise leaching analyses of allanite and monazite, and source characteristics of Pb point to an origin of the pegmatites by melting of the surrounding late Archaean and Palaeoproterozoic country rocks. Hydrothermal activity took place after pegmatite emplacement and continued below the closure temperature of magnetite at 1800–1650 Ma. Because of the relatively inert and refractory nature of magnetite, Pb-isotopic measurements from this mineral may be of help to understand the metamorphic evolution of geologicallycomplex terrains.

  2. EVALUACIÓN DE LA MATERIA ORGÁNICA EN EL RÍO FRÍO SOPORTADA EN EL QUAL2K Versión 2.07

    Directory of Open Access Journals (Sweden)

    JORGE VIRGILIO RIVERA GUTIRREZ

    2011-01-01

    Full Text Available El presente artículo estudia el comportamiento de la materia orgánica como carga contaminante en la zona más impactada del río Frío ubicada al sur occidente del Departamento de Santander. El modelamiento condiciona una calibración para minimizar el error paramétrico de las variables que soportan la degradación de la carga orgánica. La información del sistema hidrogeométrico, oxígeno disuelto, carbono, nitrógeno, patógenos y variables meteorológicas son necesarias para el modelamiento. El error paramétrico es calculado aplicando el algoritmo de Monte Carlo y la probabilidad de incertidumbre generalizada, GLUE, sigla inglesa que signifi ca (Generalized Likelihood Uncertainty Estimation. Los parámetros o tasas cinéticas presentan un coefi ciente de determinación (R2 promedio de 0.88 y las variables 0.92. El estudio de la simulación muestra como 61.9 ton.d-1 de carga orgánica vertidas por 38,3000 habitantes de Floridablanca y Bucaramanga, acumulan en el río 16.85 ton.d-1 generando cambios en el balance del oxígeno disuelto como resultado del aumento del carbono y nitrógeno orgánico.

  3. Development of new generation tools for introduction and enhanced use of advanced nuclear fuel types in Czech nuclear reactors. Czech Ministry of Trade and Industry Project 1H-PK2/07 within the POKROK programme. Final report

    International Nuclear Information System (INIS)

    The following topics were studied: (1) Stationary and quasi-stationary models and modules of neutron physics of the reactor core; (2) Preparation and processing of spectrally dependent effective cross section data and libraries; (3) Stationary and quasi-stationary models of thermal technology of the fuel and reactor core; (4) Dynamic models of physics and thermal technology of the fuel and reactor core; (5) Technological and user interface of the complex; and (6) Standardization of the methods. (P.A.)

  4. A Comment on „Two distinctive granite suites in SW Bohemian Massif and their record of emplacement: Constraints from geochemistry and Zircon 207Pb/206Pb geochronology“ by Siebel et al. Journal of Petrology 49, 1853-1872

    Czech Academy of Sciences Publication Activity Database

    Finger, F.; René, Miloš

    2009-01-01

    Roč. 50, č. 4 (2009), s. 591-593. ISSN 0022-3530 R&D Projects: GA MŠk MEB060802 Institutional research plan: CEZ:AV0Z30460519 Keywords : Bohemian Massif * Moldanubian Zone * granite Subject RIV: DB - Geology ; Mineralogy Impact factor: 3.738, year: 2009

  5. Multibeam collection for KN207-02: Multibeam data collected aboard Knorr from 2012-05-09 to 2012-06-11, departing from St. George's, Bermuda and returning to Ponta Delgada, Azores

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  6. Multibeam collection for KN207-01: Multibeam data collected aboard Knorr from 2012-04-21 to 2012-05-04, departing from Woods Hole, MA and returning to St. George's, Bermuda

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  7. Radiohalogenation of biomolecules. An experimental study on radiohalogen preparation, precursor synthesis, radiolabeling and biodistribution

    International Nuclear Information System (INIS)

    Radiohalogens are widely used in nuclear medicine, both as tool for diagnostic in vivo imaging, and in radionuclide therapy. This study deals with the use of radiohalogens; separation, precursor synthesis, labeling and biological behavior. The focus is on 211At and 124I, the former being a candidate for nuclide therapy and the latter potentially useful for diagnostic imaging and Auger-electron based radiotherapy. For astatine the separation, labeling and some biological behavior is described, and for iodine the latter two. Astatine was separated from an irradiated bismuth target by dry distillation. A novel cryotrap was developed for the isolation of astatine and subsequent synthesis of radiolabeled compounds. 5-[211At]astato-2'-deoxyuridine (AUdR) and N-succinimidyl-4-[211At]astatobenzoate (SAB) were synthesized in 95% respectively 90% radiochemical yields. The former is incorporated into DNA of proliferating cells and can therefore be used as an endoradiotherapeutic agent. The latter is a conjugate for the astatination of proteins. Human epidermal growth factor (hEGF) was tagged with astatine using three approaches: a) direct labeling of native hEGF, b) conjugation with SAB, and c) direct labeling of an hEGF - 7-(3-aminopropyl)-7,8-dicarba-nido-undecaborate(1-) conjugate. The overall labeling yields were 3.5% for direct labeling, 44% for SAB and 70% for the hEGF-nido-carborane conjugate. A new route to N-succinimidyl 3- and 4- [124I]iodobenzoate, two reagents for radioiodination of proteins is described affording 90% radiochemical yield. Three radioiodinated analogs of PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxyam ide, a peripheral-type benzodiazepine receptor antagonist, were synthesized. All three analogs were obtained in >90% radiochemical yield. Synthesis and application of 5-[124I]iodo-2'-deoxyuridine (IUdR) is presented. The closo-dodecaborate anion was evaluated as prosthetic group for radioiodination of macromolecules

  8. 211At production and recovery: first results of a new start

    International Nuclear Information System (INIS)

    Full text: 211At is the only alpha-emitting isotope which can be introduced into organic molecular structures by covalent chemical binding and possesses superior decay characteristics for therapeutic applications when compared with other alpha emitters. However, its production requires a minimum of 27,5 MeV alpha-particles, which are relatively rarely available. In view of the revival of alpha-therapy approaches a production of 211At has been set up at the MHH cyclotron (MC-35). The first aim of this project was to establish a target- and work-up-system for the reliable production of several ten MBq-quantities of 211At for animal- and cell-research. An aluminum-target-system holds a 1.3 cm diameter Bi-disc of 0.25 mm thickness. The disk is pressed onto a the aluminum backing with 2 tons/cm2. The front is covered with a 125 μm Al foil, cooled by a He jet which is separated from the vacuum by a 250 μm Ti foil. Starting with 27.5 MeV alpha-particles the resulting target-energy is 25 MeV. This relatively low energy is chosen to avoid any contamination with 210At and 210Po in the first experimental period. A beam current of 10 μA for 15 min (9 mCoulomb) yields 16.4 MBq 211At theoretically. Astatine is recovered from the target by a dry distillation technique, using various gases as a transport support-medium. The small all-quartz distillation-apparatus is heated up to 900 oC. Astatine is recovered in a small cool able vessel containing various trapping media. Distillation and trapping can be monitored with small radioactivity monitors. The whole system fits in a cubical 0.5 m glove box. Continuous monitoring of the distillation process allowed to optimize the heating rate, the transport support-medium and its flow-rate. Various trapping solutions were tested for their efficiency. Different beam dispersion in the target seems to influence the release and distillation of astatine from the molten bismuth-target. Two different release patterns were observed. The first

  9. Dicty_cDB: Contig-U10221-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available snviersirvtvtsfs*qnhqwlssgiddl limkttqsgfegfhrdkytslketkdrvfatcsyckldhtihcl*iiqkylnnsnslysi sllkltlvpfkrpfss...ggag 206 Query: 207 ccgaattctcagagacctatttaaccggtgacaatagtaaagttgtagccacagatacca 266 |||||||||||||||||||||||...||||||||||||||||||||||||||||||||||||| Sbjct: 207 ccgaattctcagagacctatttaaccggtgacaatagtaaagttgtagccacagatacc...atgggtaaacggagttgaggt 386 Query: 387 tgtcatgcgtgagaatcaatggcgtcgtattaagacctccaatggcaaggaacaaggctc... 446 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 387 tgtcatgcgtgagaatcaatggcgtcgtattaagacctc

  10. Protein (Cyanobacteria): 275623 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available ZP_03271730.1 1117:4877 1150:2576 35823:117 129910:207 513049:207 GUN4 domain prote...in Arthrospira maxima CS-328 MMTKCPVCETEYTENEVETCSVCGYDLTPYPPIDEIPSELWEKEKKRIAVAKRVWKSSQSQVKSAQLMVSHLQSYLYETTRNIYGFTQSQSQLPSQSQAI...ASQSQLLSRLESQSQAIASQSQLLSRLESQVKAIASQLPSQSQAIASQLPSQSQAIASQLPSQSQAIASQLPSQSQAIASQLQSQSQAIASQLQSQSQVIASQLQSQSQAI...ASQLQSQSQVIASQLQSQSQVIASQLQSQSQAIASQSQLLSRLESQVEAIAFQLPSQSQAIASQSQLLSRLESQSQAI...ASQLPSQSQAIASQLPSQSQAIASQLPSQSQAIASQLPSQSQAIASQLPSQSQAIASQLDESITEAVADITSIVSSSSGFDYSQLDR

  11. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    OpenAIRE

    BAYRAM, Ali

    1998-01-01

    In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 1...

  12. Human radiation studies: Remembering the early years: Oral history of Dr. Patricia Wallace Durbin, Ph.D., conducted November 11, 1994

    International Nuclear Information System (INIS)

    This report is a transcript of an interview of Dr. Patricia Wallace Durbin by representatives of the US DOE Office of Human Radiation Research. Dr. Durbin was selected for this interview because of her knowledge of the human plutonium injections and her recollections of key figures, especially Joseph Hamilton. After a brief biographical sketch Dr. Durbin discusses her loss of research funding from DOE, her recollections concerning research into strontium metabolism as part of Project Sunshine, her recollections relating to the rationale for studies of human metabolism of radionuclides, her remembrances of Dr. Hamilton's Astatine and Plutonium research, and her experiences in gathering archival records concerning these researches

  13. Tradutor e intérprete de língua de sinais: história, experiências e caminhos de formaçãoDOI: 10.5007/2175-7968.2010v2n26p207

    Directory of Open Access Journals (Sweden)

    Gisele Iandra Pessini Anater

    2010-10-01

    Full Text Available The aim of this article is to present Sign Language Translators and Interpreters (SLTIs using current reflections and traditional longstanding concepts of the profession. Even locating interpreters of oral languages and of sign languages in the same chronological line, one should note the significant and clear differences between the two. Based on Rodrigues and Burgos (2001, and on the experiences of Brazilian SLTIs, we outline and highlight the characteristics that differentiate professionals working specifically with oral language from those in SLTI. It is important to mention that the result of the linguistic modality of signed language means that the competence of the SLTI appears to be invisible, thus making it difficult for professionals in this field to be recognized. It is very common for SLTIs to be understood as simply collaborators or facilitators of communication, while the reality is that the functions of the SLTI are much more extensive. By having to deal with the peculiarities of sign language, the SLTI needs to acquire some of its fundamental elements and have exhaustive experience at the frontier of two cultures, as well as bearing responsibilities that are elements in the construction of his or her subjectivity. By presenting questions to those who operate in this field, we highlight the difficulties found in their experiences with the language, with the practice of translating and interpreting, and above all, with the hearing impaired community. We highlight the educational routes that these SLTIs have taken to become professionals in order to guarantee their visibility.

  14. Scholars in International Relations Cite Books More Frequently than Journals: More Research is Needed to Better Understand Research Behaviour and Use. A Review of: Zhang, Li. ʺCitation Analysis for Collection Development: A Study of International Relations Journal Literature.ʺ Library Collections, Acquisitions, and Technical Services 31.3‐4 (2007: 195‐207.

    Directory of Open Access Journals (Sweden)

    Megan von Isenburg

    2009-09-01

    Full Text Available Objective – To determine primary type, format, language and subject category of research materials used by U.S. scholars of international relations. Also, to investigate whether research method, qualitative or quantitative, can be correlated with the type and age of sources that scholars use.Design – Citation analysis.Setting – Research articles published in three journals on international relations with high impact factors: International Organization, International Studies Quarterly, and World Politics.Subjects – A random sample of cited references taken from the 410 full‐length research articles published in these journals from 2000 to 2005. Cited references of articles written by authors of foreign institutions (i.e., non‐American institutions, as well as cited references of editorial and research notes, comments, responses, and review essays were excluded.Methods – Cited references were exported from ISI’s Social Science Citation Index (SSCI to MS Excel spreadsheets for analysis. Data was verified against original reference lists. Citations were numbered and identified by source format, place of publication (foreign or domestic, age, and language used, if other than English. The author used a random number generator to select a random sample of 651 from a total of 29,862 citations. Citations were randomly drawn from each journal according to the proportion of the journals’ citations to the total. These citations were analyzed by material type and language. The author also used the Library of Congress Classification Outline to identify the subject category of each book and journal citation in the sample. A separate sampling method was used to investigate if there is a relationship between research methodology and citation behaviour. Each of the original 410 articles was categorized according to research method: quantitative, qualitative or a combination of the two. Two articles representing qualitative research and two representing quantitative research were randomly selected from each of the three journals for each of the six years. Subsequently, five citations from each of the resulting pool of 72 articles were randomly selected to create a sample of 360 citations. These citations were analyzed by material type and age of source.Main Results – Analysis of the citation data showed that books (including monographs, edited books, book chapters and dictionaries made up 48.2% of the total citations; journals (including scholarly and non‐scholarly titles made up 38.4% of the citations; and government publications made up 4.5% of the citations. Electronic resources, which primarily refer to Web sites and digital collections in this study, represented 1.7% of the citations. Other sources of citations included magazines (1.1%, newspapers (1.1%, working papers (1.1%, theses (0.9%, conference papers not yet published as articles (0.6%, and a miscellaneous category, which included items such as committee minutes, radio broadcasts, unpublished materials and personal communications (2.5%. The average age of book citations was 14.3 years and the median age was 8 years. Foreign language citations represented 3.7% of the 651 total citations. The top ranked foreign languages were German (7, French (5, Russian (4, Spanish (3, Korean (2 and Swedish (number not given. Subject analysis of the citations revealed that 38% of all citations were from international relations and two related disciplines, political science, political theory, and public administration. Subject areas outside international relations included social sciences (23.4% ‐ including economics, commerce, industries and finance, history (16.3%, sociology (6.2%, and law (5.9%. Citations from philosophy, psychology, military science and general works together made up 7.3% of the total citations. Citations from science, linguistics, literature, geography and medicine made up less than 2% of the total.Authors of qualitative research articles were more likely to cite books (56.7% than journals (29.4% while authors of quantitative research articles were more likely to cite journals (58.3% than books (28.9%. Authors of qualitative research articles were also more likely to cite government publications and electronic resources than those of quantitative articles. However, authors of quantitative research articles were more likely to cite other materials, such as dissertations, conference papers, working papers and unpublished materials.The age of cited materials for both qualitative and quantitative research articles is similar. Citations to recent materials up to 5 years old were most frequent, followed by materials 6 to 10 years old, materials 11 to 15 years old, and those 26 or more years old. The least frequently cited materials were 16 to 20 and 21 to 25 years old.Conclusion – Scholars in international relations primarily cite books, followed by journals and government publications. Citations to electronic resources such as Web sites and digital collections, and to other materials are far less common. Scholars primarily cite English‐language materials on international relations and related subjects. Authors of qualitative research articles are more likely to cite books than journals, while authors of quantitative research articles are more likely to cite journals than books. Recent materials are more frequently cited than older materials, though materials that are more than 26 years old are still being cited regularly.

  15. Scholars in International Relations Cite Books More Frequently than Journals: More Research is Needed to Better Understand Research Behaviour and Use. A Review of: Zhang, Li. ʺCitation Analysis for Collection Development: A Study of International Relations Journal Literature.ʺ Library Collections, Acquisitions, and Technical Services 31.3‐4 (2007): 195‐207.

    OpenAIRE

    Megan von Isenburg

    2009-01-01

    Objective – To determine primary type, format, language and subject category of research materials used by U.S. scholars of international relations. Also, to investigate whether research method, qualitative or quantitative, can be correlated with the type and age of sources that scholars use.Design – Citation analysis.Setting – Research articles published in three journals on international relations with high impact factors: International Organization, International Studies Quarterly, and Wor...

  16. Semi-Inclusive Jet measurements in Au plus Au collisions at root S NN= 200 GeV at STAR

    Czech Academy of Sciences Publication Activity Database

    Rusňák, Jan

    Trieste : S I S S A, 2015, s. 207. ISSN 1824-8039. [The European Physical Society Conference on High Energy Physics . Vienna (AT), 22.07.2015-29.07.2015] R&D Projects: GA ČR GA13-20841S Institutional support: RVO:61389005 Keywords : STAR collaboration * RHIC LHC * collisions Subject RIV: BG - Nuclear, Atomic and Molecular Physics , Colliders http://pos.sissa.it/archive/conferences/234/207/EPS-HEP2015_207.pdf

  17. Dicty_cDB: Contig-U00979-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tttttttaatgaacnaa 134 Query: 135 naaattcnagtaaaatcnaaagagnttatgatattaccnatgntntaagnccnttaggtc 194 ||||||||||...|||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 135 naaattcnagtaaaatcnaaagagnttatgatattaccnatgntnt...) Strand = Plus / Minus Query: 125 aatgaacnaanaaattcnagtaaaatcnaaagagnttatgatattaccna...agtaaaatcnaaagagnttatgatattaccnatgntntaagn 25 Query: 185 ccnttaggtctaatccgnaaaac 207 |||||||||||||||||||||||

  18. Fishery potential of the Thana - Bassein creek system

    Digital Repository Service at National Institute of Oceanography (India)

    Jyothi, E.A.; Nair, V.R.

    stream_size 4 stream_content_type text/plain stream_name J_Indian_Fish_Assoc_20_7.pdf.txt stream_source_info J_Indian_Fish_Assoc_20_7.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  19. Subjective evaluation of affective habituation to positive and negative stimuli

    Czech Academy of Sciences Publication Activity Database

    Poláčková Šolcová, Iva; Lacev, A.

    2015. s. 207-207. [International conference on emotions, well-being and health /6./. 25.10.2015-27.10.2015, Tilburg] R&D Projects: GA ČR(CZ) GP14-02889P Institutional support: RVO:68081740 Keywords : emotion * physiological measurement * gender differences Subject RIV: AN - Psychology

  20. 27 CFR 479.101 - Registration of firearms.

    Science.gov (United States)

    2010-04-01

    ... period established under section 207 of the Gun Control Act of 1968 (82 Stat. 1235). (c) A person shown... the possessors thereof under the provisions of section 207 of the Gun Control Act of 1968. (e) A... the possession of or under the control of the United States. This registry shall be known as...

  1. THE FATE OF MDACH1-EXPRESSING CELLS IN THE DORSAL PART OF THE LATERAL VENTRICLES FOLLOWING FOCAL CEREBRAL ISCHEMIA

    Czech Academy of Sciences Publication Activity Database

    Butenko, Olena; Benešová, Jana; Mikešová, M.; Honsa, Pavel; Džamba, Dávid; Kriška, Ján; Rusňáková, Vendula; Kubista, Mikael; Anděrová, Miroslava

    2013-01-01

    Roč. 61, Supplement 1 (2013), S207-S207. ISSN 0894-1491. [European Meeting on Glial Cell Function in Health and Disease /11./. 03.07.2013-06.07.2013, Berlin] Institutional support: RVO:68378041 Keywords : neuroscience * astrocyte Subject RIV: FH - Neurology

  2. EPA STANDARDS NETWORK FACT SHEET: ISO 14000: INTERNATIONAL ENVIRONMENTAL MANAGEMENT STANDARDS

    Science.gov (United States)

    This flyer provides an overview of the ISO 14000 series of International standards, supplying a brief history, structure of the Technical Committee (TC) 207, structure of the U.S. Technical Advisory Group (TAG) to ISO TC-207, status of the Standards development as of June 1997, w...

  3. 76 FR 72213 - Tapered Roller Bearings From China; Notice of Commission determination To Conduct a Full Five...

    Science.gov (United States)

    2011-11-22

    ... part 201), and part 207, subparts A, D, E, and F (19 CFR part 207), as amended, 76 FR 61937 (October 6... responses to its notice of institution (76 FR 45853, August 1, 2011) were adequate.\\2\\ A record of the... COMMISSION Tapered Roller Bearings From China; Notice of Commission determination To Conduct a Full...

  4. Synthesis, Molecular Structure, and Electrochemistry of 1-Ferrocenyl-1,2-dicarba-closo-dodecaboranes

    Czech Academy of Sciences Publication Activity Database

    Korotvička, A.; Šnajdr, I.; Štěpnička, P.; Císařová, I.; Janoušek, Zbyněk; Kotora, M.

    -, č. 15 (2013), s. 2789-2798. ISSN 1434-1948 Grant ostatní: GA ČR(CZ) GAP207/11/0338; GAČR(CZ) GAP207/11/0705 Institutional support: RVO:61388963 Keywords : carboranes * metallocenes * structure elucidation * electrochemistry * addition Subject RIV: CA - Inorganic Chemistry Impact factor: 2.965, year: 2013

  5. Case studies of some major oil spills around India

    Digital Repository Service at National Institute of Oceanography (India)

    SenGupta, R.

    stream_size 11 stream_content_type text/plain stream_name I.O_21_Century_Linkage_Networking_1998_207.pdf.txt stream_source_info I.O_21_Century_Linkage_Networking_1998_207.pdf.txt Content-Encoding ISO-8859-1 Content-Type text...

  6. Full Article: Stoichiometry, Vibrational Modes and Structure of Molten Nb2O5-K2S2O7 Mixtures

    DEFF Research Database (Denmark)

    Boghosian, S.; Borup, F.; Berg, Rolf W.

    The dissolution reaction of Nb205 in pure molten K2S207 has been studied and high temperature Raman spectroscopy has been used for determining the vibrational and structural properties of the Nb(V) complex(es) formed according to the reaction Nb205 + n S207(2-) -> complex. By means of a recently...

  7. 75 FR 68543 - Airworthiness Directives; Cessna Aircraft Company Models 150, 152, 170, 172, 175, 177, 180, 182...

    Science.gov (United States)

    2010-11-08

    ... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant... Company Models 150, 152, 170, 172, 175, 177, 180, 182, 185, 188, 190, 195, 206, 207, 210, T303, 336, and..., 177, 180, 182, 185, 188, 190, 195, 206, 207, 210, T303, 336, and 337 series airplanes. AD 87-20-03...

  8. 10 CFR Appendix L to Part 110 - Illustrative List of Byproduct Materials Under NRC Export/Import Licensing Authority a

    Science.gov (United States)

    2010-01-01

    ...) Antimony 126 (Sb 126) Arsenic 73 (As 73) Arsenic 74 (As 74) Arsenic 76 (As 76) Arsenic 77 (As 77) Barium 131 (Ba 131) Barium 133 (Ba 133) Barium 140 (Ba 140) Bismuth 207 (Bi 207) Bismuth 210 (Bi 210) Bromine...) Polonium 209 (Po 209) Polonium 210 (Po 210) Potassium 42 (K 42) Praseodymium 142 (Pr 142) Praseodymium...

  9. Extending the set of variables in propositional logics

    Czech Academy of Sciences Publication Activity Database

    Noguera, Carles; Cintula, Petr

    Helsinki: University of Helsinki, 2015 - (Nevalainen, I.; Virtanen, M.; Seppälä, P.). s. 207-207 [CLMPS 2015. Congress of Logic, Methodology and Philosophy of Science /15./. 03.08.2015-08.08.2015, Helsinki] Institutional support: RVO:67985807 ; RVO:67985556 Subject RIV: BA - General Mathematics

  10. Experiments using coincidence methods

    International Nuclear Information System (INIS)

    Experiments on γ spectroscopy using the simple coincidence techniques, including investigation of angular distribution of γ radiation from annihilation process in decay of Na22, γ - γ angular correlation technique in decay of Co60, decay scheme study of Bi207 and life time measurement of nuclear Pb207 excited state have been carried out. (author)

  11. Drug: D08332 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08332 Drug Pentalamide (INN); Hestar (TN) C12H17NO2 207.1259 207.2689 D08332.gif Dermatological, local fung...icide CAS: 5579-06-6 PubChem: 96025019 LigandBox: D08332 NIKKAJI: J149.173C ATOM 15

  12. 76 FR 31629 - Helical Spring Lock Washers From China and Taiwan; Institution of Five-Year Reviews Concerning...

    Science.gov (United States)

    2011-06-01

    ... antidumping duty order on imports of helical spring lock washers from Taiwan (58 FR 34567). On October 19... of helical spring lock washers from China and Taiwan (71 FR 37904). The Commission is now conducting...), and part 207, subparts A, D, E, and F (19 CFR part 207), as most recently amended at 74 FR...

  13. 77 FR 25744 - Certain Polyester Staple Fiber From China; Institution of a Five-Year Review

    Science.gov (United States)

    2012-05-01

    ... order on imports of certain polyester staple fiber from China (72 FR 30545). The Commission is...), and part 207, subparts A, D, E, and F (19 CFR part 207), as most recently amended at 74 FR 2847... employment statute for Federal employees, and Commission rule 201.15(b)(19 CFR 201.15(b)), 73 FR 24609 (May...

  14. 75 FR 60817 - Non-Frozen Concentrated Apple Juice From China

    Science.gov (United States)

    2010-10-01

    ... antidumping duty order on imports of non-frozen concentrated apple juice from China (65 FR 35606). Following... continuation of the antidumping duty order on imports of non- frozen concentrated apple juice from China (70 FR...), and part 207, subparts A, D, E, and F (19 CFR part 207), as most recently amended at 74 FR...

  15. Child Labor Laws and Career Education Incentive Act of 1977-- Conflict or Compatibility?

    Science.gov (United States)

    Kazanas, H. C.; Miller, F. M.

    1978-01-01

    After reviewing federal and state child labor legislation in connection with the Career Education Incentive Act of 1977 (PL 95-207), the authors found that most state child labor laws did not provide the flexibility needed to implement PL 95-207 on a broad basis. Some compatibility must be found. (MF)

  16. Anvendelse af alternative isoleringsmaterialer

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place

    2003-01-01

    Resume af By og Byg Anvisning 207 om anvendelse af alternative isoleringsmaterialer, udarbejdet af Statens Byggeforskningsinstitut under udviklingsprogrammet "Miljø- og arbejdsmiljøvenlig isolering"......Resume af By og Byg Anvisning 207 om anvendelse af alternative isoleringsmaterialer, udarbejdet af Statens Byggeforskningsinstitut under udviklingsprogrammet "Miljø- og arbejdsmiljøvenlig isolering"...

  17. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    Directory of Open Access Journals (Sweden)

    Ali BAYRAM

    1998-03-01

    Full Text Available In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 10, 50 and 259 mm/min. Strength properties of dual-phase steels were investigated depending on annealing temperature, ratio of martensite and loading rate.

  18. A route for polonium 210 production from alpha-particle irradiated bismuth-209 target

    International Nuclear Information System (INIS)

    A method is proposed for production of polonium-210 via the 209Bi(α,3n)210 At nuclear reaction. Bombardment of a bismuth-209 target was performed with a 37 MeV alpha-particle beam that leads to the production of astatine-210 (T1/2 = 8.1 h), which decays to polonium-210. It is purified from the bismuth target matrix by employing liquid-liquid extraction using tributyl phosphate (TBP) in para-xylene from 7 M hydrochloric acid. Back extraction of polonium-210 was performed by 9 M nitric acid. This method allows to purify a tracer amount of Po-210 (2.6 x 10-13 mol) from macroscopic amount of Bi (2.8 x 10-2 mol).

  19. Effective bond orders from two-step spin–orbit coupling approaches: The I{sub 2}, At{sub 2}, IO{sup +}, and AtO{sup +} case studies

    Energy Technology Data Exchange (ETDEWEB)

    Maurice, Rémi, E-mail: remi.maurice@subatech.in2p3.fr; Montavon, Gilles [SUBATECH, CNRS UMR 6457, IN2P3/EMN Nantes/Université de Nantes, 4 rue Alfred Kastler, BP 20722, 44307 Nantes Cedex 3 (France); Réal, Florent; Gomes, André Severo Pereira; Vallet, Valérie [Laboratoire PhLAM, CNRS UMR 8523, Université de Lille, 59655 Villeneuve d’Ascq Cedex (France); Galland, Nicolas [CEISAM, UMR CNRS 6230, Université de Nantes, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3 (France)

    2015-03-07

    The nature of chemical bonds in heavy main-group diatomics is discussed from the viewpoint of effective bond orders, which are computed from spin–orbit wave functions resulting from spin–orbit configuration interaction calculations. The reliability of the relativistic correlated wave functions obtained in such two-step spin–orbit coupling frameworks is assessed by benchmark studies of the spectroscopic constants with respect to either experimental data, or state-of-the-art fully relativistic correlated calculations. The I{sub 2}, At{sub 2}, IO{sup +}, and AtO{sup +} species are considered, and differences and similarities between the astatine and iodine elements are highlighted. In particular, we demonstrate that spin–orbit coupling weakens the covalent character of the bond in At{sub 2} even more than electron correlation, making the consideration of spin–orbit coupling compulsory for discussing chemical bonding in heavy (6p) main group element systems.

  20. Effective bond orders from two-step spin–orbit coupling approaches: The I2, At2, IO+, and AtO+ case studies

    International Nuclear Information System (INIS)

    The nature of chemical bonds in heavy main-group diatomics is discussed from the viewpoint of effective bond orders, which are computed from spin–orbit wave functions resulting from spin–orbit configuration interaction calculations. The reliability of the relativistic correlated wave functions obtained in such two-step spin–orbit coupling frameworks is assessed by benchmark studies of the spectroscopic constants with respect to either experimental data, or state-of-the-art fully relativistic correlated calculations. The I2, At2, IO+, and AtO+ species are considered, and differences and similarities between the astatine and iodine elements are highlighted. In particular, we demonstrate that spin–orbit coupling weakens the covalent character of the bond in At2 even more than electron correlation, making the consideration of spin–orbit coupling compulsory for discussing chemical bonding in heavy (6p) main group element systems

  1. Different ways to improve the clinical effectiveness of radioimmunotherapy in solid tumors

    Directory of Open Access Journals (Sweden)

    Chatal Jean-Francois

    2009-09-01

    Full Text Available Radioimmunotherapy (RIT has been proven effective in the treatment of radiosensitive non-Hodgkin lymphoma but, for radioresistant solid tumors, new approaches are necessary to improve the clinical effectiveness. A real improvement has been the introduction of the pretargeting technology which appeared to be able to significantly increase tumor-to-normal organ uptake ratios.Another very promising approach consists in associating RIT with other treatment modalities. Finally the use of alpha particle-emitting radionuclides such as astatin-211 or bismuth-213 (alpha-RIT should allow to efficiently eradicate disseminated microscopic clusters of tumor cells or isolated tumor cells which fit well with the short path length of alpha particles.

  2. Sequential radioimmunotherapy with 177Lu- and 211At-labeled monoclonal antibody BR96 in a syngeneic rat colon carcinoma model

    DEFF Research Database (Denmark)

    Eriksson, Sophie E; Elgström, Erika; Bäck, Tom;

    2014-01-01

    UNLABELLED: Alpha-particle emitters, such as astatine-211 (211At), are generally considered suitable for the treatment of small cell clusters due to their short path length, while beta-particle emitters, for example, Lutetium-177 (177Lu), have a longer path length and are considered better for...... small, established tumors. A combination of such radionuclides may be successful in regimens of radioimmunotherapy. In this study, rats were treated by sequential administration of first a 177Lu-labeled antibody, followed by a 211At-labeled antibody 25 days later. METHODS: Rats bearing solid colon...... carcinoma tumors were treated with 400 MBq/kg body weight 177Lu-BR96. After 25 days, three groups of animals were given either 5 or 10 MBq/kg body weight of 211At-BR96 simultaneously with or without a blocking agent reducing halogen uptake in normal tissues. Control animals were not given any 211At-BR96...

  3. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

    2013-01-01

    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  4. Development of 211At Chemistry for Labelling Biomolecules

    International Nuclear Information System (INIS)

    Our studies have demonstrated that high recovery of 211At can be obtained using a “wet chemistry” approach to isolation from the bismuth target. We have also demonstrated that direct labelling of antibody-B10 conjugates with 211At can be performed in high yields, and that the astatinated antibodies are stable to in vivo deastatination. While these results will allow us to enter clinical studies with 211At-labelled antibodies, the chemistry associated with 211At is not fully understood. Therefore, it is important that many more basic studies to be conducted with 211At, so the optimal labelling reagent for each type of disease-targeting agent becomes apparent

  5. Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status

    DEFF Research Database (Denmark)

    Lyckesvärd, Madeleine Nordén; Delle, Ulla; Kahu, Helena;

    2014-01-01

    Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ((211)At), concentrated in the thyroid by the same...... levels of γH2AX decreased during the first 24h in both cycling and stationary cultures and complete repair was seen in all cultures but cycling cells exposed to (211)At. Compared to stationary cells alpha particles were more harmful for cycling cultures, an effect also seen at the pChk2 levels...... cultures at a modest level of damage, clearly demonstrating that cell cycle status influences the relative effectiveness of alpha particles....

  6. An improved synthesis of an 125I and 211At labelled benzamide for melanoma imaging

    International Nuclear Information System (INIS)

    Recent studies have indicated that benzamides can exhibit affinity for malignant melanoma and may be exploited diagnostically in the treatment of this cancer. Radioiodinated N-(2-diethylaminoethyl)-3-[123I/131I]iodo-4-methoxybenzamide (*I-IMBA) is a benzamide with promising diagnostic properties. A new synthesis procedure was developed to obtain 125I-IMBA suitable for use in vivo. The assets of the procedure include the use of less toxic reagents and better reproducible results when radiolabelling the precursor. The procedure also facilitates the synthesis of the astatinated N-(2-diethylaminoethyl)-3-[211At]astatine-4-methoxybenzamide (211At-AMBA), a new benzamide with a therapeutic potential. The regiospecific no-carrier-added 125I- and 211At-labeling of the benzamide is performed by demetalation of an organotin precursor. Using tributylstannyl as a leaving group, the radiochemical yield obtained after 15 minutes of reaction was 70 %-90 % for both 125I-IMBA and 211At-AMBA. The labelling was performed in a solution of MeOH:AcOH with NCS as the oxidising agent. The organotin precursor N-(2-diethylaminoethyl)-3-(tri-n-butylstannyl)-4-methoxy-benzamide was synthesized from 3-bromo-4-methoxybenzoic acid, with n-BuLi (2 eq) and Bu3SnCl (1 eq) in THF, giving 3-(tri-n-butylstannyl)-4-methoxybenzoic acid. The amide function was introduced by converting the acid group into an active N-succinimidyl-ester, a good leaving group in the reaction with 2-(diethylamino)ethylamine. The overall yield of the organotin precursor was 65 %

  7. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: bruce.marsh@cern.ch [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others

    2013-12-15

    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  8. Historical trends in the lead isotopic composition of archival Sphagnum mosses from Scotland (1838-2000).

    Science.gov (United States)

    Farmer, John G; Eades, Lorna J; Atkins, Hannah; Chamberlain, David F

    2002-01-15

    The analysis of almost 200 Scottish Sphagnum moss samples collected over the past 170 years has revealed trends in the isotopic composition of lead similar to those previously established for dated Scottish lake sediments and peat bogs, lending credibility to these proxy records of atmospheric lead contamination and deposition. The effect of temporal variations in contributions from sources such as smelting of indigenous lead ores (206Pb/207Pb approximately 1.16-1.18), coal combustion (206Pb/207Pb approximately 1.17-1.19), and the use of imported Australian lead (206Pb/207Pb approximately 1.04) was clearly seen in the Scottish moss 206Pb/207Pb record. This showed some differences from the corresponding archival herbage record for the south of England, where the initial influence of Australian lead occurred earlier, at the end of the 19th century. A significant decline from a 206Pb/ 207Pb value of approximately 1.17 in the Scottish moss record began in the 1920s and continued until the 1980s (206Pb/207Pb approximately 1.12). The success of measures to reduce lead emissions to the atmosphere over the past 20 years in the U.K., in particular from petrol-engined vehicles using alkyl lead additives manufactured primarily from Australian lead, is evident in both the increasing 206Pb/207Pb ratio and falling lead concentration data for Scottish moss. PMID:11827048

  9. The alpha-galactosidase type A gene aglA from Aspergillus niger encodes a fully functional alpha-N-acetylgalactosaminidase

    Czech Academy of Sciences Publication Activity Database

    Kulik, Natallia; Weignerová, L.; Filipi, Tomáš; Pompach, Petr; Novák, Petr; Mrázek, H.; Slámová, Kristýna; Bezouška, K.; Křen, Vladimír; Ettrich, Rüdiger

    2010-01-01

    Roč. 20, č. 11 (2010), s. 1410-1419. ISSN 0959-6658 R&D Projects: GA MŠk(CZ) LC06010; GA ČR GAP207/10/1934; GA ČR GAP207/10/1040; GA ČR GA303/09/0477; GA ČR GAP207/10/0321 Institutional research plan: CEZ:AV0Z60870520; CEZ:AV0Z50200510; CEZ:AV0Z10750506 Keywords : α-N- acetylgalactosaminidase * α-galactosidase * Aspergillus niger * substrate binding * molecular modeling Subject RIV: CE - Biochemistry Impact factor: 3.791, year: 2010

  10. A-Salivary antibody responses as an indicator of waterborne infections: Pilot community study before and after installation of UV treatment

    Science.gov (United States)

    This ongoing project involves the development, validation and pilot application of a multiplex immunoassay based on Luminex microsphere technology to measure salivary antibody responses to the potentially-waterborne pathogens, noroviruses (Norwalk, VA387 and VA207), rotaviruses, ...

  11. Demand for gasoline is more price-inelastic than commonly thought

    Czech Academy of Sciences Publication Activity Database

    Havránek, T.; Iršová, Z.; Janda, Karel

    2012-01-01

    Roč. 34, č. 1 (2012), s. 201-207. ISSN 0140-9883 Institutional support: RVO:67985998 Keywords : gasoline demand * price elasticity * publication selection bias Subject RIV: AH - Economics Impact factor: 2.538, year: 2012

  12. Sex differences in cardiovascular function

    Czech Academy of Sciences Publication Activity Database

    Kolář, František; Ošťádal, Bohuslav

    2013-01-01

    Roč. 207, č. 4 (2013), s. 584-587. ISSN 1748-1708 Institutional support: RVO:67985823 Keywords : heart * vascular * risk factors * sex Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 4.251, year: 2013

  13. Can campo rupestre vegetation be floristically delimited based on vascular plant genera?

    Czech Academy of Sciences Publication Activity Database

    Alves, R. J. V.; Kolbek, Jiří

    2010-01-01

    Roč. 207, č. 1 (2010), s. 67-79. ISSN 1385-0237 Institutional research plan: CEZ:AV0Z60050516 Keywords : vegetation classification * endemism * Brazil Subject RIV: EF - Botanics Impact factor: 1.880, year: 2010

  14. 76 FR 16043 - Agency Information Collection (Department of Veterans Affairs Acquisition Regulations Clause 852...

    Science.gov (United States)

    2011-03-22

    ... care services. It requires the bidder/offeror prior to contract award to furnish evidence of....207-3, Right of First Refusal of Employment. An agency may not conduct or sponsor, and a person is...

  15. Wetted channel and bar features for the Tillamook, Trask, Wilson, Kilchis, and Miami Rivers, Oregon in 1967

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  16. Wetted channel and bar features for the Nehalem River, Oregon in 1967

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  17. Disentangling the effects of water chemistry and substratum structure on moss-dwelling unicellular and multicellular micro-organisms in spring-fens

    Czech Academy of Sciences Publication Activity Database

    Hájková, P.; Bojková, J.; Fránková, Markéta; Opravilová, V.; Hájek, M.; Kintrová, K.; Horsák, M.

    2011-01-01

    Roč. 70, suppl.1 (2011), s. 54-64. ISSN 1129-5767 Institutional research plan: CEZ:AV0Z60050516 Keywords : diatoms * rotifers * testate amoebae Subject RIV: EF - Botanics Impact factor: 1.207, year: 2011

  18. Room temperature liquid ionization chambers using tetramethylsilane

    International Nuclear Information System (INIS)

    Ionization pulse signals due to 207Bi conversion electrons were observed in ionization chambers filled with tetramethylsilane which was purified by a simple method. Pulse height spectra and its variation with the electric field were measured. (orig.)

  19. Poznámka o náhrobku císaře Friedricha III. a reflexe sepulchrálního sochařství v českých cestopisech 1450 - 1550

    Czech Academy of Sciences Publication Activity Database

    Chlíbec, Jan

    Praha : Arte factum, 2002 - (Prix, D.), s. 207-215 ISBN 80-903230-1-4 Institutional research plan: CEZ:AV0Z8033913 Keywords : Gerhaert van Leyden * Friedrich III Subject RIV: AL - Art, Architecture, Cultural Heritage

  20. Aerial photo mosaic of the Nehalem River, Oregon in 1967

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  1. Aerial photo mosaic of the Tillamook and Trask Rivers, Tillamook basin, Oregon in 1939

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  2. Aerial photo mosaic of the Wilson and Kilchis Rivers, Tillamook basin, Oregon in 1939

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  3. Aerial photo mosaic of the Nehalem River, Oregon in 1939

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  4. Wetted channel and bar features for the Nehalem River, Oregon in 2009

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  5. Wetted channel and bar features for the Nehalem River, Oregon in 1939

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  6. Uranium hydrothermal deposits

    Czech Academy of Sciences Publication Activity Database

    René, Miloš

    New York : Nova Science Publishers, 2012 - (Vasiliev, A.; Sidorov, M.), s. 211-244 ISBN 978-1-62081-207-5 Institutional research plan: CEZ:AV0Z30460519 Keywords : uranium * hydrothermal deposits * uraninite Subject RIV: DB - Geology ; Mineralogy

  7. Aerial photo mosaic of the Miami River, Tillamook basin, Oregon in 1939

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  8. The Theory of Global Governance, Constitutionalization and Comparative Constitutional Law

    Czech Academy of Sciences Publication Activity Database

    Blahož, Josef

    2013-01-01

    Roč. 3, č. 3 (2013), s. 195-207. ISSN 1805-8396 Institutional support: RVO:68378122 Keywords : globalization of political culture * global constitutionalism * comparative constitutional law Subject RIV: AG - Legal Sciences

  9. K problému sekundárního (nepřímého) tlumočení v moderním českém biblickém překladu

    Czech Academy of Sciences Publication Activity Database

    Bartoň, Josef

    2013-01-01

    Roč. 5, č. 2 (2013), s. 207-216. ISSN 1804-1132 Institutional support: RVO:67985955 Keywords : Czech Biblical translation * indirect translation * second-hand translation Subject RIV: AI - Linguistics

  10. 33 CFR 162.40 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal).

    Science.gov (United States)

    2010-07-01

    ... section in 33 CFR part 207. ... such owners and operators should be particularly careful to moor or anchor well away from the main ship... anchor in the ship channel. (e) Water skiing. Water skiing in the waterway is prohibited between...

  11. Wetted channel and bar features for the Tillamook, Trask, Wilson, Kilchis, and Miami Rivers, Oregon in 2009

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  12. Channel centerline for the Nehalem River, Oregon in 2005

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  13. Wetted channel and bar features for the Nehalem River, Oregon in 2005

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  14. Channel centerline for the Tillamook, Trask, Wilson, Kilchis, and Miami Rivers, Oregon in 2005

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  15. Channel centerline for the Tillamook, Trask, Wilson, Kilchis, and Miami Rivers, Oregon in 1967

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  16. Channel centerline for the Nehalem River, Oregon in 1967

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  17. Channel centerline for the Tillamook, Trask, Wilson, Kilchis, and Miami Rivers, Oregon in 1939

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  18. Channel centerline for the Nehalem River, Oregon in 2009

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  19. Cholesterol and fat lowering with hydrophobic polysaccharide derivatives

    Czech Academy of Sciences Publication Activity Database

    Čopíková, J.; Taubner, T.; Tůma, J.; Synytsya, A.; Dušková, Dagmar; Marounek, Milan

    2015-01-01

    Roč. 116, č. 1 (2015), s. 207-214. ISSN 0144-8617 Institutional support: RVO:67985904 Keywords : hydrophobically modified polysaccharides * structure * thermal analysis Subject RIV: ED - Physiology Impact factor: 4.074, year: 2014

  20. A comprehensive two-dimensional gel protein database of noncultured unfractionated normal human epidermal keratinocytes: towards an integrated approach to the study of cell proliferation, differentiation and skin diseases

    DEFF Research Database (Denmark)

    Celis, J E; Madsen, Peder; Rasmussen, H H;

    1991-01-01

    207 known proteins in alphabetical order), "basal cell markers", "differentiation markers", "proteins highly up-regulated in psoriatic skin", "microsequenced proteins" and "human autoantigens". For reference, we have also included 2-D gel (isoelectric focusing) patterns of cultured normal and...

  1. 12 CFR 250.165 - Bankers' acceptances: definition of participations.

    Science.gov (United States)

    2010-01-01

    ... (junior bank). (b) The legislative history of section 207 of the BESA indicates that Congress intended... (daily ed. October 1, 1982) (remarks by Rep. Barnard). The legislative history also indicates...

  2. Inessa Josing jälle fookuses

    Index Scriptorium Estoniae

    1999-01-01

    Kunstiajakiri "Flash Art" illustreerib 1999. a. suvenumbris (nr. 207) uudist Euroopa noorte kunstnike biennaali Manifesta 3 toimumisest 2000. a. suvel Ljubljanas fotoga Inessa Josingu aknakujundusest (jõuluaken Tallinnas Viru t. teksasepoele)

  3. Workshop Verordnete Nachbarschaften. Transformationsprozesse im Grenzraum Deutschland – Polen – Tschechien seit dem Zweiten Weltkrieg , Dresden, 20.–22. November 2014.

    Czech Academy of Sciences Publication Activity Database

    Nosková, Jana

    Vol. 56. 1. Münster: Waxmann Verlag, 2015, s. 207-210. ISBN 978-3-8309-3196-6. Institutional support: RVO:68378076 Keywords : borderlands * Czech Republic * Germany * Poland * transformation Subject RIV: AC - Archeology, Anthropology, Ethnology

  4. 76 FR 44323 - National Grid Transmission Services Corporation; Bangor Hydro Electric Company; Notice of...

    Science.gov (United States)

    2011-07-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission National Grid Transmission Services Corporation; Bangor Hydro Electric... of the Commission's Rules of Practice and Procedure, 18 CFR 385.207, National Grid...

  5. Population size of the monocarpic perennial Peucedanum arenarium Waldst. et Kit. with regard to experimentally tested management strategies

    Czech Academy of Sciences Publication Activity Database

    Šerá, Božena; Válková, D.; Kocianová, E.; Šerý, M.; Feráková, V.; Hodálová, I.

    2013-01-01

    Roč. 42, č. 2 (2013), s. 449-454. ISSN 0556-3321 Institutional support: RVO:67179843 Keywords : grasslands * biology * plant * flora * rangeland Subject RIV: EH - Ecology, Behaviour Impact factor: 1.207, year: 2013

  6. Latest Achievements on Climate Change and Forest Interactions in a Polluted Environment

    Czech Academy of Sciences Publication Activity Database

    Carriero, G.; Tuovinen, J.-P.; Clarke, N.; Matteucci, G.; Matyssek, R.; Wieser, G.; Mikkelsen, J. D.; Fischer, R.; Cudlín, Pavel; Serengil, Y.; Boscaleri, F.; Calfapietra, Carlo; Feng, Z.; Paoletti, E.

    2014-01-01

    Roč. 4, č. 3 (2014), s. 197-207. ISSN 2163-0429 Institutional support: RVO:67179843 Keywords : air pollution * climate change * forests * supersites * COST * FP0903 Action Subject RIV: EH - Ecology, Behaviour

  7. Seitse retke isamaale : mälestuslikud esseed / Hellar Grabbi ; [toimetanud Urmas Tõnisson ; kaanekujundus: Mari Ainso ; esikaane foto: Helmuth Neider

    Index Scriptorium Estoniae

    Grabbi, Hellar, 1929-

    2010-01-01

    Mälestusteraamatus meenutatakse ka kohtumisi Toomas Hendrik Ilvesega raadiojaamas "Vaba Euroopa" töötamise ajal (lk. 233, 285-286), 1988. a. Münchenis ilmunud almanahhis Põrp! ilmunud esseed "Niikuinii" (lk. 207)

  8. Intermittent hemodialysis is superior to continuous veno-venous hemodialysis/hemodiafiltration to eliminate methanol and formate during treatment for methanol poisoning

    Czech Academy of Sciences Publication Activity Database

    Zakharov, S.; Pelclová, D.; Navrátil, Tomáš; Běláček, J.; Kurcová, I.; Komzák, O.; Šálek, T.; Latta, J.; Turek, R.; Boček, R.; Kučera, C.; Hubáček, J. A.; Fenclová, Z.; Petřík, V.; Čermák, M.; Hovda, K. E.

    2014-01-01

    Roč. 86, č. 1 (2014), s. 199-207. ISSN 0085-2538 Institutional support: RVO:61388955 Keywords : Intermittent hemodialysis * hemodiafiltration * methanol poisonings Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 8.563, year: 2014

  9. Surface functionalization of mesoporous antimony doped tin oxide by metalorganic reaction

    Czech Academy of Sciences Publication Activity Database

    Müller, V.; Haase, F.; Rathouský, Jiří; Fattakhova-Rohlfing, D.

    2012-01-01

    Roč. 137, č. 1 (2012), s. 207-212. ISSN 0254-0584 Institutional support: RVO:61388955 Keywords : oxides * organometallic compounds * chemical synthesis Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.072, year: 2012

  10. A Possible Scenario of Energy Transport in the 17th May 2002 Flare

    Czech Academy of Sciences Publication Activity Database

    Kotrč, Pavel; Kashapova, L. K.; Frolova, A.S.; Kupryjakov, Ju. A.

    2009-01-01

    Roč. 33, č. 1 (2009), s. 207-215. ISSN 1845-8319 Institutional research plan: CEZ:AV0Z10030501 Keywords : solar flare * accelerated particles * chromosphere and corona Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

  11. Molodõje godõ razvedtshika Shtirlitsa / Julia Shishova

    Index Scriptorium Estoniae

    Shishova, Julia

    2008-01-01

    Mosfilmi stuudio Ded Moroz filmib alates 2.07. Eestis telesarja "Issajev". Seriaali tegevus leiab aset 1921. aastal Tallinnas ja Venemaal. Filmivõtted Haapsalu raudteejaamas. Artikli autor osales võtetel statistina

  12. Interaction of two memory enhancing herbal drugs Memory Plus and Mentat with diazepam and phenytoin sodium in mice

    Directory of Open Access Journals (Sweden)

    Neera R. Gupta

    2015-04-01

    Conclusion: Subchronic administration of MP and Mentat shows significant interaction with diazepam and PS. Further human studies are warranted to confirm these findings. [Int J Basic Clin Pharmacol 2015; 4(2.000: 203-207

  13. Channel centerline for the Nehalem River, Oregon in 1939

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  14. Wetted channel and bar features for the Tillamook, Trask, Wilson, Kilchis, and Miami Rivers, Oregon in 1939

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  15. Aerial photo mosaic of the Tillamook basin, Oregon in 1967

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  16. Wetted channel and bar features for the Tillamook, Trask, Wilson, Kilchis, and Miami Rivers, Oregon in 2005

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....

  17. Cryptorchidism in boys with posterior urethral valves.

    Science.gov (United States)

    Krueger, R P; Hardy, B E; Churchill, B M

    1980-07-01

    A review of 207 male children with poterior urethral valves revealed an over-all incidence of cryptorchidism of 12 per cent. This association of cryptorchidism in boys with posterior urethral valves has not been described previously. PMID:6106069

  18. Organ Donation and Transplantation Statistics

    Science.gov (United States)

    ... You are here Home » Organ Donation and Transplantation Statistics There are currently 121,678 people waiting for ... org/2015/view/v2_07.aspx Facts and statistics provided by the United States Renal Data System , ...

  19. SwissProt search result: AK061101 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK061101 006-207-A12 (P17538) Chymotrypsinogen B precursor (EC 3.4.21.1) [Contains: Chymotrypsin... B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C] CTRB1_HUMAN 3e-30 ...

  20. Channel centerline for the Tillamook, Trask, Wilson, Kilchis, and Miami Rivers, Oregon in 2009

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Tillamook Bay subbasins and Nehalem River basins encompass 1,369 and 2,207 respective square kilometers of northwestern Oregon and drain to the Pacific Ocean....