WorldWideScience

Sample records for astatine 206

  1. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  2. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  3. Adsorption interaction of astatine species with quartz and gold surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Serov, A. [Paul Scherrer Institute, Villigen (Switzerland). Lab. for Radiochemistry and Environmental Chemistry; Bern Univ. (Switzerland). Dept. for Chemistry and Biochemistry; Aksenov, N.; Bozhikov, G. [Joint Institute for Nuclear Research, Dubna (RU). Flerov Lab. of Nuclear Reactions] (and others)

    2011-07-01

    The adsorption interaction of various astatine species with quartz and gold surfaces was investigated by gas chromatography methods. Due to variations of the redox potential of the carrier gas elemental astatine, astatine oxide and hypo-astatic acid have been produced. The identification of the astatine compounds is based on the analogy assumption to the gas phase chemistry of the closest homologues in group 17 of the periodic table, iodine and bromine. The deposition temperatures as well as enthalpies of adsorption have been determined for the astatine species. The enhancement of the metallic character within group 17 towards higher Z is clearly confirmed. Macroscopic properties (sublimation enthalpy) of previously unstudied AtO{sub 2} and HAtO were estimated. The determined data for elemental astatine were compared to available literature data. Based on the obtained experimental results possible designs of experiments for studying of chemical properties of the recently discovered element 117 can be suggested. (orig.)

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. IT 206 Uop Material - it206dotcom

    OpenAIRE

    honey

    2015-01-01

    IT 206 Entire Course For more course tutorials visit www.uopit206.com   IT 206 Week 1 CheckPoint Formatting Issues IT 206 Week 1 DQ 1 and DQ 2 IT 206 Week 2 CheckPoint Knowing Where You Placed Your Document IT 206 week 2 Assignment Microsoft Word Exercise IT 206 Week 3 CheckPoint Simplifying Your Excel Usage IT 206 week 3 DQ 1 and DQ 2 IT 206 Week 4 CheckPoint The Risk of Macros IT 206 Week 4 Assignment Microsoft Excel Exercise IT 206 Week ...

  6. IT 206 courses / snaptutorial

    OpenAIRE

    IT 210 snaptutorial

    2015-01-01

    For more classes visit www.snaptutorial.com   IT 206 Week 1 CheckPoint Formatting Issues IT 206 Week 1 DQ 1 and DQ 2 IT 206 Week 2 CheckPoint Knowing Where You Placed Your Document IT 206 Week 2 Assignment Microsoft Word Exercise IT 206 Week 3 CheckPoint Simplifying Your Excel Usage IT 206 Week 3 DQ 1 and DQ 2 IT 206 Week 4 CheckPoint The Risk of Macros IT 206 Week 4 Assignment Microsoft Excel Exercise IT 206 Week 5 CheckPoint Mail Merging ...

  7. Discovery of the astatine, radon, francium, and radium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  8. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  9. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  10. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  11. 44 CFR 206.49-206.60 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false 206.49-206.60 Section 206.49-206.60 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process §§ 206.49-206.60...

  12. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  13. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  14. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom;

    2015-01-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...... and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting...... vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method...

  15. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  16. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  17. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  18. IT 206 UOP COURSE TUTORIAL/UOPHELP

    OpenAIRE

    mumki

    2015-01-01

    For more course tutorials visit www.uophelp.com IT 206 Week 1 CheckPoint Formatting Issues IT 206 Week 1 DQ 1 and DQ 2 IT 206 Week 2 CheckPoint Knowing Where You Placed Your Document IT 206 Week 2 Assignment Microsoft Word Exercise IT 206 Week 3 CheckPoint Simplifying Your Excel Usage IT 206 Week 3 DQ 1 and DQ 2 IT 206 Week 4 CheckPoint The Risk of Macros IT 206 Week 4 Assignment Microsoft Excel Exercise IT 206 Week 5 CheckPoint Mail Merging IT 206 ...

  19. IT 206 UOP COURSE TUTORIAL/ UOPHELP

    OpenAIRE

    BHARGAVI

    2015-01-01

    For more course tutorials visit www.uophelp.com IT 206 Week 1 CheckPoint Formatting Issues IT 206 Week 1 DQ 1 and DQ 2 IT 206 Week 2 CheckPoint Knowing Where You Placed Your Document IT 206 Week 2 Assignment Microsoft Word Exercise IT 206 Week 3 CheckPoint Simplifying Your Excel Usage IT 206 Week 3 DQ 1 and DQ 2 IT 206 Week 4 CheckPoint The Risk of Macros IT 206 Week 4 Assignment Microsoft Excel Exercise IT 206 Week 5 CheckPoint Mail Merging IT 206 ...

  20. IT 206 UOP Course Tutorial / Tutorialoutlet

    OpenAIRE

    dawan

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com   IT 206 Week 1 CheckPoint Formatting Issues IT 206 Week 1 DQ 1 and DQ 2 IT 206 Week 2 CheckPoint Knowing Where You Placed Your Document IT 206 Week 2 Assignment Microsoft Word Exercise IT 206 Week 3 CheckPoint Simplifying Your Excel Usage IT 206 Week 3 DQ 1 and DQ 2 IT 206 Week 4 CheckPoint The Risk of Macros IT 206 Week 4 Assignment Microsoft Excel Exercise IT 206 Week 5 CheckPoint Mail M...

  1. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  2. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  3. 40 CFR 91.206 - Trading.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Trading. 91.206 Section 91.206... EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Averaging, Banking, and Trading Provisions § 91.206 Trading. (a... manufacturers in trading. These credits must be used in the same averaging set as generated. (b) Credits...

  4. 40 CFR 89.206 - Trading.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Trading. 89.206 Section 89.206... EMISSIONS FROM NEW AND IN-USE NONROAD COMPRESSION-IGNITION ENGINES Averaging, Banking, and Trading Provisions § 89.206 Trading. (a) Requirements for Tier 1 engines rated at or above 37 kW. (1) A...

  5. 40 CFR 90.206 - Trading.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Trading. 90.206 Section 90.206... Trading Provisions § 90.206 Trading. (a) An engine manufacturer may exchange emission credits with other engine manufacturers in trading, subject to the trading restriction specified in § 90.207(c)(2)....

  6. 24 CFR 904.206 - Funding.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Funding. 904.206 Section 904.206... HOUSING HOMEOWNERSHIP OPPORTUNITIES Homeownership Counseling and Training § 904.206 Funding. (a) Source of funds. For purpose of funding counseling and training pursuant to this subpart and for establishing...

  7. 40 CFR 59.206 - Variances.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Variances. 59.206 Section 59.206... Compound Emission Standards for Consumer Products § 59.206 Variances. (a) Any regulated entity who cannot... control may apply in writing to the Administrator for a variance. The variance application shall...

  8. 10 CFR 490.206 - Violations.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Violations. 490.206 Section 490.206 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.206 Violations. Violations of this subpart are subject to investigation and enforcement under...

  9. 40 CFR 240.206-1 - Requirement.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirement. 240.206-1 Section 240.206-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.206-1...

  10. 44 CFR 206.113 - Eligibility factors.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Eligibility factors. 206.113 Section 206.113 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Households § 206.113 Eligibility factors. (a) Conditions of eligibility. In general, FEMA may...

  11. 24 CFR 206.15 - Insurance.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Insurance. 206.15 Section 206.15... MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOME EQUITY CONVERSION MORTGAGE INSURANCE Eligibility; Endorsement § 206.15 Insurance. Mortgages originated under...

  12. 40 CFR 240.206 - Vectors.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Vectors. 240.206 Section 240.206 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.206 Vectors....

  13. 14 CFR 206.1 - Emergency transportation.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Emergency transportation. 206.1 Section 206.1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS... EXEMPTIONS § 206.1 Emergency transportation. Notwithstanding the provisions of section 41101 of the...

  14. 24 CFR 206.37 - Credit standing.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Credit standing. 206.37 Section 206... CONVERSION MORTGAGE INSURANCE Eligibility; Endorsement Eligible Mortgagors § 206.37 Credit standing. Each mortgagor must have a general credit standing satisfactory to the Secretary....

  15. 44 CFR 206.31 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 206.31 Section 206.31 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process § 206.31 Purpose....

  16. 44 CFR 206.39 - Notification.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Notification. 206.39 Section 206.39 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process § 206.39 Notification....

  17. 44 CFR 206.46 - Appeals.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Appeals. 206.46 Section 206.46 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process § 206.46 Appeals....

  18. 48 CFR 16.206-1 - Description.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Description. 16.206-1 Section 16.206-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 16.206-1 Description. A...

  19. 24 CFR 206.41 - Counseling.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Counseling. 206.41 Section 206.41... CONVERSION MORTGAGE INSURANCE Eligibility; Endorsement Eligible Mortgagors § 206.41 Counseling. (a) List... receive counseling. (b) Information to be provided. A counselor must discuss with the mortgagor: (1)...

  20. Dicty_cDB: SSC206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSC206 (Link to dictyBase) - - - Contig-U15659-1 SSC206E (Link... to Original site) - - - - - - SSC206E 560 Show SSC206 Library SS (Link to library) Clone ID SSC206 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSC2-A/SSC206Q.Seq.d/ Representative seq. ID SSC20...6E (Link to Original site) Representative DNA sequence >SSC206 (SSC206Q) /CSM/SS/SSC2-A/SSC206Q.Seq.d/ GGGTT...quences producing significant alignments: (bits) Value SSC206 (SSC206Q) /CSM/SS/SSC2-A/SSC206Q.Seq.d/ 1096 0

  1. 38 CFR 3.206 - Divorce.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Divorce. 3.206 Section 3..., Compensation, and Dependency and Indemnity Compensation Evidence Requirements § 3.206 Divorce. The validity of a divorce decree regular on its face, will be questioned by the Department of Veterans Affairs...

  2. 48 CFR 9.206-3 - Competition.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Competition. 9.206-3... CONTRACTOR QUALIFICATIONS Qualifications Requirements 9.206-3 Competition. (a) Presolicitation. If a... solicitation to ascertain whether the number of sources is adequate for competition. (See 9.204(a) for...

  3. 44 CFR 206.362 - Responsibilities.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Responsibilities. 206.362 Section 206.362 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Responsibilities. (a) The local government shall submit the financial information required by FEMA in...

  4. 44 CFR 206.372 - Responsibilities.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Responsibilities. 206.372 Section 206.372 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Responsibilities. (a) The local government shall submit the financial information required by FEMA in...

  5. 44 CFR 206.200 - General.

    Science.gov (United States)

    2010-10-01

    ... to State and Local Governments,” published at 44 CFR part 13, place requirements on the State in its... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false General. 206.200 Section 206.200 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF...

  6. 44 CFR 206.32 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 206.32 Section 206.32 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... the FEMA-State Agreement and published in the Federal Register....

  7. 44 CFR 206.1 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... and emergencies declared by the President before November 23, 1988 were published in 44 CFR part 205... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 206.1 Section 206.1 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND...

  8. 44 CFR 206.345 - Exceptions.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Exceptions. 206.345 Section 206.345 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF..., and of the access thereto; (4) Repair of facilities for scientific research, including but not...

  9. 5 CFR 842.206 - Involuntary retirement.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Involuntary retirement. 842.206 Section... (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-BASIC ANNUITY Eligibility § 842.206 Involuntary retirement... separates from the service involuntarily after completing 25 years of service, or after becoming age 50...

  10. 9 CFR 206.3 - Monthly report.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Monthly report. 206.3 Section 206.3 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND... contracts the packer currently is using for the purchase of swine for slaughter at each plant. Each...

  11. 9 CFR 206.1 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Definitions. 206.1 Section 206.1 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND..., between a packer and a producer for the purchase of swine for slaughter, except a negotiated purchase...

  12. 44 CFR 206.343 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Scope. 206.343 Section 206.343 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND... orientation which is unrelated to development is not subject to the requirements of these regulations....

  13. 7 CFR 765.206 - Junior liens.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Junior liens. 765.206 Section 765.206 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... determinations for future requests for assistance and may adversely impact such requests. (b) Conditions...

  14. 44 CFR 206.38 - Presidential determination.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Presidential determination. 206.38 Section 206.38 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process §...

  15. 44 CFR 206.225 - Emergency work.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Emergency work. 206.225 Section 206.225 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... that a threat exists, including identification and evaluation of the threat and recommendations of...

  16. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  17. z206sc_video_observations

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of DS 781 presents video observations from cruise Z206SC for the Santa Barbara Channel region and beyond in southern California. The vector data file is...

  18. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  19. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  20. Star Formation in Henize 206

    Science.gov (United States)

    2004-01-01

    [figure removed for brevity, see original site] IRA-MIPS Composite [figure removed for brevity, see original site] Visible [figure removed for brevity, see original site] IRAC [figure removed for brevity, see original site] MIPS The LMC is a small satellite galaxy gravitationally bound to our own Milky Way. Yet the gravitational effects are tearing the companion to shreds in a long-playing drama of 'intergalactic cannibalism.' These disruptions lead to a recurring cycle of star birth and star death. Astronomers are particularly interested in the LMC because its fractional content of heavy metals is two to five times lower than is seen in our solar neighborhood. [In this context, 'heavy elements' refer to those elements not present in the primordial universe. Such elements as carbon, oxygen and others are produced by nucleosynthesis and are ejected into the interstellar medium via mass loss by stars, including supernova explosions.] As such, the LMC provides a nearby cosmic laboratory that may resemble the distant universe in its chemical composition. The primary Spitzer image, showing the wispy filamentary structure of Henize 206, is a four-color composite mosaic created by combining data from an infrared array camera (IRAC) at near-infrared wavelengths and the mid-infrared data from a multiband imaging photometer (MIPS). Blue represents invisible infrared light at wavelengths of 3.6 and 4.5 microns. Note that most of the stars in the field of view radiate primarily at these short infrared wavelengths. Cyan denotes emission at 5.8 microns, green depicts the 8.0 micron light, and red is used to trace the thermal emission from dust at 24 microns. The separate instrument images are included as insets to the main composite. An inclined ring of emission dominates the central and upper regions of the image. This delineates a bubble of hot, x-ray emitting gas that was blown into space when a massive star died in a supernova explosion millions of years ago. The shock waves

  1. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  2. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  3. 44 CFR 206.62 - Available assistance.

    Science.gov (United States)

    2010-10-01

    ... HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Emergency Assistance § 206.62 Available... threat of a catastrophe; (b) Coordinate all disaster relief assistance (including voluntary assistance... Stafford Act; and (g) Assist State and local governments in the distribution of medicine, food, and...

  4. 24 CFR 235.206 - Substitute mortgagors.

    Science.gov (United States)

    2010-04-01

    ... MORTGAGE INSURANCE AND ASSISTANCE PAYMENTS FOR HOME OWNERSHIP AND PROJECT REHABILITATION Contract Rights and Obligations-Homes for Lower Income Families § 235.206 Substitute mortgagors. (a) Selling mortgagor... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Substitute mortgagors....

  5. 32 CFR 206.2 - Eligibility.

    Science.gov (United States)

    2010-07-01

    ... NATIONAL SECURITY EDUCATION PROGRAM (NSEP) GRANTS TO INSTITUTIONS OF HIGHER EDUCATION § 206.2 Eligibility. Any accredited U.S. institution of higher education, as defined by section 1201(a) of the Higher Education Act of 1965 (20 U.S.C. 1141(a)), may apply for and receive a grant. This includes 2- and...

  6. 44 CFR 206.2 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... major disaster. (22) State: Any State of the United States, the District of Columbia, Puerto Rico, the... SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE General § 206.2 Definitions. (a) General. The.... Stafford Disaster Relief and Emergency Assistance Act, Public Law 93-288, as amended. (2)...

  7. 44 CFR 206.151 - Food commodities.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Food commodities. 206.151... Food commodities. (a) The Administrator will assure that adequate stocks of food will be ready and... section, the Administrator may direct the Secretary of Agriculture to purchase food commodities...

  8. 24 CFR 206.117 - General.

    Science.gov (United States)

    2010-04-01

    ... MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOME EQUITY CONVERSION MORTGAGE INSURANCE Contract Rights and Obligations Hud Responsibility to Mortgagors § 206.117... because of the default of the mortgagee. The Secretary may hold a second mortgage to secure repayment...

  9. 23 CFR 230.206 - Monitoring supportive services.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Monitoring supportive services. 230.206 Section 230.206 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS EXTERNAL PROGRAMS Supportive Services for Minority, Disadvantaged, and Women Business Enterprises § 230.206...

  10. 41 CFR 101-27.206-3 - Packaging.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Packaging. 101-27.206-3 Section 101-27.206-3 Public Contracts and Property Management Federal Property Management Regulations...-Management of Shelf-Life Materials § 101-27.206-3 Packaging. To the extent feasible and economical,...

  11. 30 CFR 206.260 - Allocation of washed coal.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Allocation of washed coal. 206.260 Section 206... MANAGEMENT PRODUCT VALUATION Federal Coal § 206.260 Allocation of washed coal. (a) When coal is subjected to washing, the washed coal must be allocated to the leases from which it was extracted. (b) When the...

  12. 30 CFR 206.459 - Allocation of washed coal.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Allocation of washed coal. 206.459 Section 206... MANAGEMENT PRODUCT VALUATION Indian Coal § 206.459 Allocation of washed coal. (a) When coal is subjected to washing, the washed coal must be allocated to the leases from which it was extracted. (b) When the...

  13. 30 CFR 206.155 - Accounting for comparison.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Accounting for comparison. 206.155 Section 206... MANAGEMENT PRODUCT VALUATION Federal Gas § 206.155 Accounting for comparison. (a) Except as provided in... subpart. (b) The requirement for accounting for comparison contained in the terms of leases will govern...

  14. 31 CFR 206.3 - Billing policy and procedures.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Billing policy and procedures. 206.3 Section 206.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL..., DISBURSEMENTS, AND OPERATION OF THE CASH MANAGEMENT IMPROVEMENTS FUND § 206.3 Billing policy and procedures....

  15. 44 CFR 206.141 - Disaster unemployment assistance.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Disaster unemployment assistance. 206.141 Section 206.141 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... § 206.141 Disaster unemployment assistance. The authority to implement the disaster...

  16. 40 CFR 86.206-11 - Equipment required; overview.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Equipment required; overview. 86.206-11 Section 86.206-11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.206-11 Equipment...

  17. 40 CFR 86.206-94 - Equipment required; overview.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Equipment required; overview. 86.206-94 Section 86.206-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.206-94 Equipment...

  18. 5 CFR 880.206 - Date of death.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Date of death. 880.206 Section 880.206...) RETIREMENT AND INSURANCE BENEFITS DURING PERIODS OF UNEXPLAINED ABSENCE Procedures § 880.206 Date of death... OPM, the date of death of a missing annuitant who has been determined to be dead by an...

  19. 42 CFR 438.206 - Availability of services.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Availability of services. 438.206 Section 438.206... Standards § 438.206 Availability of services. (a) Basic rule. Each State must ensure that all services... whether the location provides physical access for Medicaid enrollees with disabilities. (2)...

  20. 5 CFR 352.206 - Expiration of reemployment rights.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Expiration of reemployment rights. 352.206 Section 352.206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS....206 Expiration of reemployment rights. Reemployment rights granted under a Letter of Authority...

  1. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  2. 32 CFR 48.206 - Information regarding elections.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Information regarding elections. 48.206 Section... AND CIVILIAN RETIRED SERVICEMAN'S FAMILY PROTECTION PLAN Election of Options § 48.206 Information regarding elections. (a) All members of the Reserve component who will have accumulated sufficient...

  3. 27 CFR 25.206 - Removal of beer.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Removal of beer. 25.206... OF THE TREASURY LIQUORS BEER Removals Without Payment of Tax Beer for Personal Or Family Use § 25.206 Removal of beer. Beer made under § 25.205 may be removed from the premises where made for personal...

  4. 49 CFR 24.206 - Eviction for cause.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Eviction for cause. 24.206 Section 24.206 Transportation Office of the Secretary of Transportation UNIFORM RELOCATION ASSISTANCE AND REAL PROPERTY... cause. (a) Eviction for cause must conform to applicable State and local law. Any person who...

  5. 49 CFR 173.206 - Packaging requirements for chlorosilanes.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Packaging requirements for chlorosilanes. 173.206...-GENERAL REQUIREMENTS FOR SHIPMENTS AND PACKAGINGS Non-bulk Packaging for Hazardous Materials Other Than Class 1 and Class 7 § 173.206 Packaging requirements for chlorosilanes. (a) When § 172.101 of...

  6. 9 CFR 206.2 - Swine contract library.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Swine contract library. 206.2 Section... STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE SWINE CONTRACT LIBRARY § 206.2 Swine contract library. (a) Do... swine contract library will be made available to the public? GIPSA will summarize the information it...

  7. 9 CFR 113.206 - Wart Vaccine, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Wart Vaccine, Killed Virus. 113.206... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.206 Wart Vaccine, Killed Virus. Wart Vaccine, Killed Virus, shall be...

  8. 14 CFR 125.206 - Pitot heat indication systems.

    Science.gov (United States)

    2010-01-01

    ... flight instrument pitot heating system unless the airplane is equipped with an operable pitot heat... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pitot heat indication systems. 125.206... Equipment Requirements § 125.206 Pitot heat indication systems. (a) Except as provided in paragraph (b)...

  9. 30 CFR 206.153 - Valuation standards-processed gas.

    Science.gov (United States)

    2010-07-01

    ... Section 206.153 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Federal Gas § 206.153 Valuation standards—processed gas. (a)(1) This section... shall be by letter to the MMS Associate Director for Minerals Revenue Management or his/her...

  10. 30 CFR 206.152 - Valuation standards-unprocessed gas.

    Science.gov (United States)

    2010-07-01

    ... Section 206.152 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Federal Gas § 206.152 Valuation standards—unprocessed gas. (a)(1) This section.... The notification shall be by letter to the MMS Associate Director for Minerals Revenue Management...

  11. 48 CFR 206.302-7 - Public interest.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Public interest. 206.302-7 Section 206.302-7 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM....302-7 Public interest. (c) Limitations. For the defense agencies, the written determination to...

  12. 24 CFR 206.25 - Calculation of payments.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Calculation of payments. 206.25 Section 206.25 Housing and Urban Development Regulations Relating to Housing and Urban Development... Calculation of payments. (a) Initial payment. At closing an initial payment shall be made by the mortgagee...

  13. 44 CFR 206.47 - Cost-share adjustments.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Cost-share adjustments. 206.47 Section 206.47 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT... Consumers published annually by the Department of Labor. (c) When we determine whether to recommend a...

  14. 48 CFR 32.206 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Solicitation provisions and contract clauses. 32.206 Section 32.206 Federal Acquisition Regulations System FEDERAL ACQUISITION...) of this section); (iii) Liquidation of those financing payments by delivery payments (see...

  15. 48 CFR 1809.206-70 - Small businesses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Small businesses. 1809.206-70 Section 1809.206-70 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... status on a Qualified Products List (Mil-Bul-103) or the Qualified Manufacturers List...

  16. 18 CFR 375.206 - Procedures to close meetings.

    Science.gov (United States)

    2010-04-01

    ... meetings. 375.206 Section 375.206 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REVISED GENERAL RULES THE COMMISSION Procedures Under the Government in the... may be closed only when the Commission votes by a majority of the membership to close the meeting....

  17. 30 CFR 206.265 - Value enhancement of marketable coal.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Value enhancement of marketable coal. 206.265... MANAGEMENT PRODUCT VALUATION Federal Coal § 206.265 Value enhancement of marketable coal. If, prior to use, sale, or other disposition, the lessee enhances the value of coal after the coal has been placed...

  18. 30 CFR 206.464 - Value enhancement of marketable coal.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Value enhancement of marketable coal. 206.464... MANAGEMENT PRODUCT VALUATION Indian Coal § 206.464 Value enhancement of marketable coal. If, prior to use, sale, or other disposition, the lessee enhances the value of coal after the coal has been placed...

  19. 44 CFR 206.41 - Appointment of disaster officials.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Appointment of disaster officials. 206.41 Section 206.41 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process §...

  20. 44 CFR 206.36 - Requests for major disaster declarations.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Requests for major disaster declarations. 206.36 Section 206.36 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process §...

  1. 48 CFR 1333.206 - Initiation of a claim.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Initiation of a claim. 1333.206 Section 1333.206 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL.... Contracting officers shall promptly notify Procurement Counsel and seek legal advice upon receiving...

  2. 40 CFR 211.206-1 - Real ear method.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Real ear method. 211.206-1 Section 211... PRODUCT NOISE LABELING Hearing Protective Devices § 211.206-1 Real ear method. (a) The value of sound... “Method for the Measurement of Real-Ear Protection of Hearing Protectors and Physical Attenuation...

  3. 44 CFR 206.63 - Provision of assistance.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Provision of assistance. 206.63 Section 206.63 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT... lessen or avert the threat of a catastrophe....

  4. 29 CFR 1603.206 - Consolidation and severance of hearings.

    Science.gov (United States)

    2010-07-01

    ... PROCEDURES FOR PREVIOUSLY EXEMPT STATE AND LOCAL GOVERNMENT EMPLOYEE COMPLAINTS OF EMPLOYMENT DISCRIMINATION UNDER SECTION 304 OF THE GOVERNMENT EMPLOYEE RIGHTS ACT OF 1991 Hearings § 1603.206 Consolidation...

  5. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  6. 19 CFR 206.66 - Limited disclosure of certain confidential business information under administrative protective...

    Science.gov (United States)

    2010-04-01

    ... business information under administrative protective order. 206.66 Section 206.66 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL... certain confidential business information under administrative protective order. In an investigation...

  7. 5 CFR 734.206 - Participation in elections.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Participation in elections. 734.206... in elections. An employee may: (a) Register and vote in any election; (b) Act as recorder, watcher, challenger, or similar officer at polling places; (c) Serve as an election judge or clerk, or in a...

  8. 17 CFR 275.206(4)-8 - Pooled investment vehicles.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Pooled investment vehicles... COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT ADVISERS ACT OF 1940 § 275.206(4)-8 Pooled investment vehicles. (a) Prohibition. It shall constitute a fraudulent, deceptive, or manipulative...

  9. 27 CFR 555.206 - Location of magazines.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Location of magazines. 555... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Storage § 555.206 Location of magazines. (a) Outdoor magazines in which high explosives are stored must be located no closer to...

  10. 18 CFR 706.206 - Support of Council programs.

    Science.gov (United States)

    2010-04-01

    ... EMPLOYEE RESPONSIBILITIES AND CONDUCT Conduct and Responsibilities of Employees § 706.206 Support of Council programs. (a) When a Council program is based on law or Executive order, every employee has a positive obligation to make it function as efficiently and economically as possible and to support it...

  11. 32 CFR 206.5 - Final proposal process.

    Science.gov (United States)

    2010-07-01

    ...) MISCELLANEOUS NATIONAL SECURITY EDUCATION PROGRAM (NSEP) GRANTS TO INSTITUTIONS OF HIGHER EDUCATION § 206.5... selection criteria: (1) Importance of the problem. Each proposal will be evaluated according to the merit of how it addresses issue(s) of national capacity. The proposal must articulate the importance of...

  12. 44 CFR 206.16 - Audit and investigations.

    Science.gov (United States)

    2010-10-01

    ... OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE General § 206.16 Audit and investigations. (a) Subject to the provisions of chapter 75 of title 31, United States Code, and 44 CFR part 13... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Audit and investigations....

  13. 48 CFR 50.206 - Solicitation provisions and contract clause.

    Science.gov (United States)

    2010-10-01

    ... REGULATION CONTRACT MANAGEMENT EXTRAORDINARY CONTRACTUAL ACTIONS AND THE SAFETY ACT Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.206 Solicitation provisions and contract clause. (a) Insert the provision at 52.250-2, SAFETY Act Coverage Not Applicable, in solicitations if— (1) The...

  14. 44 CFR 206.201 - Definitions used in this subpart.

    Science.gov (United States)

    2010-10-01

    ... Administration § 206.201 Definitions used in this subpart. (a) Applicant means a State agency, local government, or eligible private nonprofit organization, as identified in Subpart H of this regulation, submitting... natural feature. Land used for agricultural purposes is not a facility. (d) Grant means an award...

  15. 31 CFR 800.206 - Convertible voting instrument.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Convertible voting instrument. 800..., AND TAKEOVERS BY FOREIGN PERSONS Definitions § 800.206 Convertible voting instrument. The term convertible voting instrument means a financial instrument that currently does not entitle its owner or...

  16. 44 CFR 206.43 - Emergency support teams.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Emergency support teams. 206... Emergency support teams. The Federal Coordinating Officer may activate emergency support teams, composed of... emergency. These emergency support teams assist the FCO in carrying out his/her responsibilities under...

  17. 31 CFR 545.206 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 545... Prohibitions § 545.206 Evasions; attempts; conspiracies. (a) Except as otherwise authorized, and... entered into or any license or permit granted prior to the effective date, any conspiracy formed for...

  18. 31 CFR 537.206 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 537... § 537.206 Evasions; attempts; conspiracies. (a) Any transaction by a U.S. person or within the United... attempts to violate any of the prohibitions set forth in this part is prohibited. (b) Any conspiracy...

  19. 31 CFR 593.206 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 593... SANCTIONS REGULATIONS Prohibitions § 593.206 Evasions; attempts; conspiracies. (a) Except as otherwise... contract entered into or any license or permit granted prior to the effective date, any conspiracy...

  20. 32 CFR 206.4 - Proposal development and review.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Proposal development and review. 206.4 Section... Proposal development and review. The purpose of this section is to explain the NSEP review process. This information if intended to aid institutions in the development of proposals and to provide guidance...

  1. 44 CFR 206.207 - Administrative and audit requirements.

    Science.gov (United States)

    2010-10-01

    ... administrative requirements of 44 CFR parts 13 and 206; (H) Compliance with the audit requirements of 44 CFR part... in FEMA regulations at 44 CFR part 13 or OMB Circular A-110 as appropriate. (2) Federal audit. In accordance with 44 CFR part 13, FEMA may elect to conduct a Federal audit of the disaster assistance grant...

  2. 10 CFR 835.206 - Limits for the embryo/fetus.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Limits for the embryo/fetus. 835.206 Section 835.206... Exposure § 835.206 Limits for the embryo/fetus. (a) The equivalent dose limit for the embryo/fetus from the... provided in § 835.206(a) shall be avoided. (c) If the equivalent dose to the embryo/fetus is determined...

  3. 30 CFR 206.173 - How do I calculate the alternative methodology for dual accounting?

    Science.gov (United States)

    2010-07-01

    ... for dual accounting? 206.173 Section 206.173 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Indian Gas § 206.173 How do I calculate the alternative methodology for dual accounting? (a) Electing a dual accounting method. (1) If you...

  4. 50 CFR 226.206 - Critical habitat for the Southern Resident killer whale (Orcinus orca).

    Science.gov (United States)

    2010-10-01

    ... killer whale (Orcinus orca). 226.206 Section 226.206 Wildlife and Fisheries NATIONAL MARINE FISHERIES... CRITICAL HABITAT § 226.206 Critical habitat for the Southern Resident killer whale (Orcinus orca). Critical habitat is designated for the Southern Resident killer whale as described in this section. The...

  5. 19 CFR 206.47 - Limited disclosure of certain confidential business information under administrative protective...

    Science.gov (United States)

    2010-04-01

    ... business information under administrative protective order. 206.47 Section 206.47 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL... Investigations for Relief From Market Disruption § 206.47 Limited disclosure of certain confidential...

  6. 28 CFR 2.206 - Travel approval and transfers of supervision.

    Science.gov (United States)

    2010-07-01

    ... supervision. 2.206 Section 2.206 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION... Supervised Releasees § 2.206 Travel approval and transfers of supervision. (a) A releasee's supervision officer may approve travel outside the district of supervision without approval of the Commission in...

  7. 19 CFR 206.17 - Limited disclosure of certain confidential business information under administrative protective...

    Science.gov (United States)

    2010-04-01

    ... Investigations Relating to Global Safeguard Actions § 206.17 Limited disclosure of certain confidential business... business information under administrative protective order. 206.17 Section 206.17 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO...

  8. 48 CFR 206.302-3 - Industrial mobilization; or engineering, development, or research capability.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Industrial mobilization; or engineering, development, or research capability. 206.302-3 Section 206.302-3 Federal Acquisition... COMPETITION REQUIREMENTS Other Than Full and Open Competition 206.302-3 Industrial mobilization;...

  9. 41 CFR 101-27.206-2 - Identification and shipping requirements.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Identification and shipping requirements. 101-27.206-2 Section 101-27.206-2 Public Contracts and Property Management Federal...-INVENTORY MANAGEMENT 27.2-Management of Shelf-Life Materials § 101-27.206-2 Identification and...

  10. 7 CFR 3560.206 - Conversion to Plan II (Interest Credit).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Conversion to Plan II (Interest Credit). 3560.206 Section 3560.206 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Rents § 3560.206 Conversion to Plan II (Interest Credit). The...

  11. 30 CFR 206.59 - May I ask MMS for valuation guidance?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false May I ask MMS for valuation guidance? 206.59 Section 206.59 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Indian Oil § 206.59 May I ask MMS for valuation guidance? You may ask MMS...

  12. The Clinical analyse of 206 patients of cerebral infarction (Abstract)

    Institute of Scientific and Technical Information of China (English)

    Mai Mai; Ti Yi Ming; Ghen Bo

    2000-01-01

    This thesis make a summary and analyse to 206 patients of cerebral infarction. The morbidity of the age from 51 to 70 is thehighist in 206 patients. It is 75.3 % a mong the patient that hypertension is original. The frequently-occurring cerebral in farction patient are 36.8 % and it is the highist. Because our hospital have purchased CT machinery, we can early diagnose cerebral infarction and do dissolving thrombus in early time, controlling blood pressure, clearing away free radical, dehydrating, di lating cerebral blood vessel, recovering treat early and so on. It reduced the appear ing of conplication and the death rate and viability by oneselfare improved obvious lv.

  13. Completion report for Well Cluster ER-20-6

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The Well Cluster ER-20-6 drilling and completion project was conducted during February, March, and April of 1996 in support of the Nevada Environmental Restoration Project at the Nevada Test Site (NTS), Nye County, Nevada. This project is part of the DOE`s Underground Test Area (UGTA) subproject at the NTS. The primary UGTA tasks include collecting geological, geophysical, and hydrological data from new and existing wells to define groundwater quality as well as pathways and rates of groundwater migration at the NTS. A program of drilling wells near the sites of selected underground nuclear tests (near-field drilling) was implemented as part of the UGTA subproject to obtain site-specific data on the nature and extent of migration of radionuclides produced by an underground nuclear explosion. The ER-20-6 near-field drilling project was originally planned to be very similar to that recently conducted at Well Cluster ER-20-5, which was designed to obtain data on the existing hydrologic regime near the site of an underground nuclear explosion (IT, 1995; IT, 1996a). However, after further consideration of the goals of the near-field drilling program and the characteristics of the BULLION site, the TWG recommended that the ER-20-6 project be redesigned to accommodate a forced-gradient experiment. This proposed experiment is expected to yield more realistic estimates of transport parameters than can be deduced from sampling and testing natural groundwater flow systems.

  14. MicroRNA-206 regulates surfactant secretion by targeting VAMP-2.

    Science.gov (United States)

    Zhang, Honghao; Guo, Yujie; Mishra, Amarjit; Gou, Deming; Chintagari, Narendranath Reddy; Liu, Lin

    2015-01-01

    Lung surfactant secretion is a highly regulated process. Our previous studies have shown that VAMP-2 is essential for surfactant secretion. In the present study we investigated the role of miR-206 in surfactant secretion through VAMP-2. VAMP-2 was confirmed to be a target of miR-206 by 3'-untranslational region (3'-UTR) luciferase assay. Mutations in the predicated miR-206 binding sites reduced the binding of miR-206 to the 3'-UTR of VAMP-2. miR-206 decreased the expression of VAMP-2 protein and decreased the lung surfactant secretion in alveolar type II cells. In conclusion, miR-206 regulates lung surfactant secretion by limiting the availability of VAMP-2 protein.

  15. Measurement of internal pairs from {sup 206}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, I.; Back, B.B.; Betts, R.R. [and others

    1995-08-01

    The failure to observe sharp sum-energy lines in measurements of {sup 238}U + {sup 181}Ta and {sup 238}U + {sup 232}Th raises the issue of the correct functioning of APEX under in-beam conditions. Extensive measurements with electron and pair emitting sources were used to demonstrate the resolution and acceptance of APEX, but the possibility remains that some unforeseen background or other effects might compromise the ability to see peaks in-beam. In order to test the functioning of APEX under the most stringent conditions, we also performed a measurement of internal pairs produced in the decay of the 2.648-MeV 3{sup -} state in {sup 206}Pb to the 2{sup +} state at 0.803 MeV. The 3{sup -} state was excited in the {sup 206}Pb + {sup 206}Pb reaction at 5.9 MeV/u with a cross section of roughly 40 mb, resulting in an expected pair cross section of approximately 16 {mu}b. It should be emphasized that this measurement represents a much stricter test of the functioning of the apparatus than the observation of sum-energy lines would represent, as the internal pair measurement requires a Doppler shift correction before the transition can be seen. These data were analyzed and clearly show the expected peak. A Doppler-corrected sum-energy spectrum showing the expected IPC line at 823 keV. At present we are evaluating the acceptance of APEX for events of this type but it is clear that the observed yield is close to expectations.

  16. High enriched lead-206 for small nuclear power plants

    International Nuclear Information System (INIS)

    In modern projects of perspective NPP the preference is returned to fast reactors (FR) with heavy liquid metal coolants. Internal self-hardening, absence of poisoning effects, compensation of uranium fuel burn-out by produced plutonium fuel and other positive features of FR will allow in the long term to lengthen operating campaign of the reactor till 10-12 of years, and service life of FR - till 30-60 of years. As is known, the coolant, circulating through the core of FR, is activated and accumulates long-lived radionuclides. Taking in account the masses of coolant materials in considered FR (20-200 tons) and the scales of an introduction of small NPP in the future, it can be problems with handling a completed coolant after FR removal from exploitation and at realization of repair and emergency activities. There, it is desirable to have a low-activation coolant with low contents of long-lived radionuclides - products of nuclear reactions. In paper, presented at the ICONE-8 conference, it is offered to use lead enriched with isotope Pb-206 as a low-activation coolant for FR. Its contents in a natural mix of lead isotopes make 24 %, and the demanded enrichment of isotope does not exceed 95-98 %. However, usage of a coolant from enriched lead can result in advancing the price of power, owing to what NPP can become noncompetitive in relation to other power sources. The purpose of the present paper - to point that interval of the prices of the product lead-206, at which one it can be demanded for nuclear engineering in large quantities. In the paper possible ways to ease the costs of obtaining the product lead-206 for the need of small nuclear engineering are also considered. (author)

  17. La eximente de miedo insuperable (art. 20.6 CP)

    OpenAIRE

    Varona Gómez, Daniel

    1999-01-01

    La te si doctoral tracte d' una causa d' exempció de la responsabilitat penal reconeguda a l'article 20.6 del vigent codi penal: la por insuperable. L' objectiu principal de la tesi és donar un contingut a aquesta eximent per tal de que trobi l'adient reconeixement als tribunals, que tradicionalment han ignorat aquesta eximent. El primer capítol de la tesi tracta del seu fonament, és a dir, de la raó o raons que han portat al legislador a reconèixer la por insuperable com a una causa de exemp...

  18. 诺基亚Asha205/206

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    诺基亚一直在不遗余力推出低端入门系列的机型,有人认为它逐渐沦为渣机之王。有人则认为制霸低端市场亦无可厚非。诺基亚最近又“很配合”地推出两款低端新机——Asha 205和206;两款均为非智能机,支持双SIM卡。

  19. 30 CFR 206.177 - What general requirements regarding transportation allowances apply to me?

    Science.gov (United States)

    2010-07-01

    ... transportation allowances apply to me? 206.177 Section 206.177 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Indian Gas Transportation Allowances..., transportation from the lease to a gas processing plant off the lease, unit, or communitized area and from...

  20. Downregulation of microRNA-206 promotes invasion and angiogenesis of triple negative breast cancer.

    Science.gov (United States)

    Liang, Zhongxing; Bian, Xuehai; Shim, Hyunsuk

    2016-08-26

    Triple negative breast tumors don't respond to Tamoxifen and Herceptin, two of the most effective medications for treating breast cancer. Additionally, triple negative breast cancer (TNBC) intrinsically resists or will eventually acquire resistance to chemotherapy. The purpose of this study is to understand better the molecular basis of TNBC as well as develop new therapeutic strategies against it. Here, we analyzed miRNA-206 expression levels in breast cancer cell lines and tissues. In addition, we investigated whether miR-206 mimics inhibited TNBC tumor invasion and angiogenesis. The results showed that miR-206 was downregulated in TNBC compared to non-TNBC cell lines and tissues. Additionally, the decreased levels of miR-206 were inversely consistent with expression levels of VEGF. Furthermore, the forced expression of miR-206 in the mimic-transfected TNBC cells downregulated VEGF, MAPK3, and SOX9 expression levels. The miR-206 mimics inhibited TNBC breast cell invasion and angiogenesis. These findings demonstrate for the first time the involvement of miRNA-206 in TNBC invasion and angiogenesis and suggest that miR-206 may be an efficient agent for therapy of TNBC. PMID:27318091

  1. 30 CFR 206.107 - How do I request a value determination?

    Science.gov (United States)

    2010-07-01

    ... Section 206.107 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Federal Oil § 206.107 How do I request a value determination? (a) You may... signed by the Assistant Secretary, Land and Minerals Management; or (2) Issue a value determination...

  2. 30 CFR 206.171 - What definitions apply to this subpart?

    Science.gov (United States)

    2010-07-01

    ... Section 206.171 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Indian Gas § 206.171 What definitions apply to this subpart? The following... the Department of the Interior. BLM means the Bureau of Land Management of the Department of...

  3. 30 CFR 206.101 - What definitions apply to this subpart?

    Science.gov (United States)

    2010-07-01

    ... Section 206.101 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Federal Oil § 206.101 What definitions apply to this subpart? The following...; (iv) The extent of participation by other owners in operations and day-to-day management of a...

  4. 30 CFR 206.51 - What definitions apply to this subpart?

    Science.gov (United States)

    2010-07-01

    ... Section 206.51 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Indian Oil § 206.51 What definitions apply to this subpart? For purposes of this... Bureau of Land Management regulations at 43 CFR 3100.0-5(d)). Person means any individual,...

  5. 9 CFR 93.206 - Declaration and other documents for poultry.

    Science.gov (United States)

    2010-01-01

    ... poultry. 93.206 Section 93.206 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND POULTRY...

  6. Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206

    KAUST Repository

    Liang, Yu

    2012-06-26

    Zfp206 (also named as Zscan10) belongs to the subfamily of C2H2 zinc finger transcription factors, which is characterized by the N-terminal SCAN domain. The SCAN domain mediates self-association and association between the members of SCAN family transcription factors, but the structural basis and selectivity determinants for complex formation is unknown. Zfp206 is important for maintaining the pluripotency of embryonic stem cells presumably by combinatorial assembly of itself or other SCAN family members on enhancer regions. To gain insights into the folding topology and selectivity determinants for SCAN dimerization, we solved the 1.85 crystal structure of the SCAN domain of Zfp206. In vitro binding studies using a panel of 20 SCAN proteins indicate that the SCAN domain Zfp206 can selectively associate with other members of SCAN family transcription factors. Deletion mutations showed that the N-terminal helix 1 is critical for heterodimerization. Double mutations and multiple mutations based on the Zfp206SCAN-Zfp110SCAN model suggested that domain swapped topology is a possible preference for Zfp206SCAN-Zfp110SCAN heterodimer. Together, we demonstrate that the Zfp206SCAN constitutes a protein module that enables C2H2 transcription factor dimerization in a highly selective manner using a domain-swapped interface architecture and identify novel partners for Zfp206 during embryonal development. 2012 The Author(s).

  7. 10 CFR 431.206 - Energy conservation standards and their effective dates.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Energy conservation standards and their effective dates. 431.206 Section 431.206 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Illuminated Exit Signs Energy Conservation Standards §...

  8. 42 CFR 411.206 - Basis for Medicare primary payments and limits on secondary payments.

    Science.gov (United States)

    2010-10-01

    ... secondary payments. 411.206 Section 411.206 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM EXCLUSIONS FROM MEDICARE AND LIMITATIONS ON MEDICARE... Medicare primary payments for services furnished to disabled beneficiaries covered under the LGHP by...

  9. 50 CFR 223.206 - Exceptions to prohibitions relating to sea turtles.

    Science.gov (United States)

    2010-10-01

    ... disconnected. This restriction applies in the Atlantic Exclusive Economic Zone (as defined in 50 CFR 600.10... measuring mesh size. This protocol applies to measuring mesh size in leaders described in 50 CFR 223.206(d... § 223.206, see the List of CFR Sections Affected, which appears in the Finding Aids section of...

  10. 44 CFR 206.37 - Processing requests for declarations of a major disaster or emergency.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Processing requests for declarations of a major disaster or emergency. 206.37 Section 206.37 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL...

  11. 44 CFR 206.34 - Request for utilization of Department of Defense (DOD) resources.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Request for utilization of Department of Defense (DOD) resources. 206.34 Section 206.34 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER...

  12. 44 CFR 206.40 - Designation of affected areas and eligible assistance.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Designation of affected areas and eligible assistance. 206.40 Section 206.40 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE...

  13. 44 CFR 206.45 - Loans of non-Federal share.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Loans of non-Federal share. 206.45 Section 206.45 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE The Declaration Process §...

  14. 44 CFR 206.181 - Use of gifts and bequests for disaster assistance purposes.

    Science.gov (United States)

    2010-10-01

    ...) Disaster-related home repair and rebuilding assistance to families for permanent housing purposes... disaster assistance purposes. 206.181 Section 206.181 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE...

  15. 41 CFR 101-27.206 - Procurement of shelf-life materials.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Procurement of shelf-life materials. 101-27.206 Section 101-27.206 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT...

  16. 5 CFR 831.206 - Continuation of coverage for former Federal employees of the Civilian Marksmanship Program.

    Science.gov (United States)

    2010-01-01

    ... Federal employees of the Civilian Marksmanship Program. 831.206 Section 831.206 Administrative Personnel... § 831.206 Continuation of coverage for former Federal employees of the Civilian Marksmanship Program. (a... support the Civilian Marksmanship Program as of the day before the date of the transfer of the Program...

  17. 40 CFR 262.206 - Labeling and management standards for containers of unwanted material in the laboratory.

    Science.gov (United States)

    2010-07-01

    ... Material for Laboratories Owned by Eligible Academic Entities § 262.206 Labeling and management standards... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Labeling and management standards for containers of unwanted material in the laboratory. 262.206 Section 262.206 Protection of...

  18. 30 CFR 206.110 - How do I determine a transportation allowance under an arm's-length transportation contract?

    Science.gov (United States)

    2010-07-01

    ... under an arm's-length transportation contract? 206.110 Section 206.110 Mineral Resources MINERALS... § 206.110 How do I determine a transportation allowance under an arm's-length transportation contract? (a) If you or your affiliate incur transportation costs under an arm's-length transportation...

  19. MiR-206在骨骼肌发育中的功能%Roles of miR-206 in skeletal muscle development

    Institute of Scientific and Technical Information of China (English)

    马国达; 罗小暖; 韩冰; 李庆章

    2012-01-01

    MicroRNAs (miRNAs) are a class of highly conserved small non-coding RNAs of ~22-nucleotides involved in post-transcriptional gene silencing. The emerging field of miRNA biology has unraveled roles for these regulatory molecules in a range of biological functions, including cell proliferation, differentiation and apoptosis. Interestingly, many miRNAs are specifically expressed in muscles. In this review, we focus on miR-206 which is unique in that it is only expressed in skeletal muscle and has been shown to play an important role in myogenesis. Importantly, dysregulation of miR-206 has been linked to muscle-related diseases, such as Duchenne muscular dystrophy and amyotrophic lateral sclerosis. In addition, a mutation in the 3'-UTR of the myostatin gene in the Texel sheep creating target sites for the microRNAs miR-206 and miR-1 leads to down regulation of myostatin expression, which is likely to cause the muscular phenotype of this breed of sheep. Therefore, miR-206 may become a novel target in optimization of muscle quantity of domestic animals and therapy of muscle-related diseases.%微RNA (microRNA,miRNA)是一类在分子进化中十分保守的非编码RNA,长度约22个核苷酸,一般情况下它在转录后水平抑制基因表达.miRNA在细胞增殖、分化、凋亡等诸多生理过程中发挥着重要作用.有些miRNA具有组织特异性表达,其中miR-206是目前发现的唯一在骨骼肌中特异表达的miRNA,它在凋节骨骼肌发生过程中扮演重要角色.miR-206表达异常与一些肌肉相关疾病如肌肉营养不良、肌萎缩性侧索硬化症等有关.此外,在Texel羊中,myostatin基因的一个点突变就产生了一个miR-206和miR-1的靶点,抑制了myostain基因的表达,从而产生了双肌表型.因此,miR-206有可能成为治疗肌肉相关疾病和畜禽改良育种的重要候选分子.

  20. Fusion of 8He with 206Pb around Coulomb barrier energies

    Directory of Open Access Journals (Sweden)

    Raabe R.

    2011-10-01

    Full Text Available The experimental study of the fusion of light neutron-rich nucleus 8He with 206Pb is reported in this work. A fusion stack of 206Pb targets has been used for this study. The most prominent evaporation residue (210Po, which has half-life of 138 days and decays by alpha emission, is populated in the reaction. Radiochemical analysis technique is used to extract the yield of this evaporation residue.

  1. Neutron capture studies of 206Pb at a cold neutron beam

    Science.gov (United States)

    Schillebeeckx, P.; Belgya, T.; Borella, A.; Kopecky, S.; Mengoni, A.; Quétel, C. R.; Szentmiklósi, L.; Trešl, I.; Wynants, R.

    2013-11-01

    Gamma-ray transitions following neutron capture in 206Pb have been studied at the cold neutron beam facility of the Budapest Neutron Centre using a metallic sample enriched in 206Pb and a natural lead nitrate powder pellet. The measurements were performed using a coaxial HPGe detector with Compton suppression. The observed -rays have been incorporated into a decay scheme for neutron capture in 206Pb . Partial capture cross sections for 206Pb(n,) at thermal energy have been derived relative to the cross section for the 1884keV transition after neutron capture in 14N . From the average crossing sum a total thermal neutron capture cross section of mb was derived for the 206Pb(n,) reaction. The thermal neutron capture cross section for 206Pb has been compared with contributions due to both direct capture and distant unbound s-wave resonances. From the same measurements a thermal neutron-induced capture cross section of mb was determined for the 207Pb(n,) reaction.

  2. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

    International Nuclear Information System (INIS)

    miRNAs, sorting as non-coding RNAs, are differentially expressed in breast tumor and act as tumor promoters or suppressors. miR-206 could suppress the progression of breast cancer, the mechanism of which remains unclear. The study here was aimed to investigate the effect of miR-206 on human breast cancers. We found that miR-206 was down-regulated while one of its predicted targets, 6-Phosphofructo-2-kinase (PFKFB3) was up-regulated in human breast carcinomas. 17β-estradiol dose-dependently decreased miR-206 expression as well as enhanced PFKFB3 mRNA and protein expression in estrogen receptor α (ERα) positive breast cancer cells. Furthermore, we identified that miR-206 directly interacted with 3′-untranslated region (UTR) of PFKFB3 mRNA. miR-206 modulated PFKFB3 expression in MCF-7, T47D and SUM159 cells, which was influenced by 17β-estradiol depending on ERα expression. In addition, miR-206 overexpression impeded fructose-2,6-bisphosphate (F2,6BP) production, diminished lactate generation and reduced cell proliferation and migration in breast cancer cells. In conclusion, our study demonstrated that miR-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration. - Highlights: • miR-206 was down-regulated and PFKFB3 was up-regulated in human breast carcinomas. • 17β-estradiol regulated miR-206 and PFKFB3 expression in ERα+ cancer cells. • miR-206directly interacted with 3′-UTR of PFKFB3 mRNA. • miR-206 fructose-2,6-bisphosphate (F2,6BP) impeded production and lactate generation. • miR-206 reduced cell proliferation and migration in breast cancer cells

  3. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

    Energy Technology Data Exchange (ETDEWEB)

    Ge, Xin; Lyu, Pengwei; Cao, Zhang; Li, Jingruo; Guo, Guangcheng; Xia, Wanjun; Gu, Yuanting, E-mail: zzyuantinggu@126.com

    2015-08-07

    miRNAs, sorting as non-coding RNAs, are differentially expressed in breast tumor and act as tumor promoters or suppressors. miR-206 could suppress the progression of breast cancer, the mechanism of which remains unclear. The study here was aimed to investigate the effect of miR-206 on human breast cancers. We found that miR-206 was down-regulated while one of its predicted targets, 6-Phosphofructo-2-kinase (PFKFB3) was up-regulated in human breast carcinomas. 17β-estradiol dose-dependently decreased miR-206 expression as well as enhanced PFKFB3 mRNA and protein expression in estrogen receptor α (ERα) positive breast cancer cells. Furthermore, we identified that miR-206 directly interacted with 3′-untranslated region (UTR) of PFKFB3 mRNA. miR-206 modulated PFKFB3 expression in MCF-7, T47D and SUM159 cells, which was influenced by 17β-estradiol depending on ERα expression. In addition, miR-206 overexpression impeded fructose-2,6-bisphosphate (F2,6BP) production, diminished lactate generation and reduced cell proliferation and migration in breast cancer cells. In conclusion, our study demonstrated that miR-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration. - Highlights: • miR-206 was down-regulated and PFKFB3 was up-regulated in human breast carcinomas. • 17β-estradiol regulated miR-206 and PFKFB3 expression in ERα+ cancer cells. • miR-206directly interacted with 3′-UTR of PFKFB3 mRNA. • miR-206 fructose-2,6-bisphosphate (F2,6BP) impeded production and lactate generation. • miR-206 reduced cell proliferation and migration in breast cancer cells.

  4. 19 CFR 206.64 - Institution of investigation or review; publication of notice; and availability for public...

    Science.gov (United States)

    2010-04-01

    ... STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL... section, excluding any confidential business information in the document. Paragraph (c) in § 206.3...

  5. Determination of the neutron resonance parameters for 206Pb and of the thermal neutron capture cross section for 206Pb and 209Bi

    International Nuclear Information System (INIS)

    Chapter 1 describes the motivation of the measurements (accelerator driven systems, stellar nucleosynthesis, neutron induced reactions on 206Pb), the present status of the neutron capture data for 206Pb and 209Bi and the structure of this work. In Chapter 2 the basic reaction theory underlying this work is described. The neutron induced reaction mechanism and formalism are explained. The parameterisation of the cross section in terms of R-matrix theory is discussed and we put particular emphasis on the statistical behaviour of the resonance parameters and the impact of the angular distribution of gamma rays following neutron capture. The relation between experimental observables and the resonance parameters is discussed together with general comments related to resonance shape analysis. Chapter 3 is focused on the determination of resonance parameters for 206Pb. We performed high-resolution transmission and capture measurements at the Time-Of-Flight (TOF) facility GELINA of the IRMM at Geel (B) and determined the resonance parameters. For nuclei like 206Pb, where the total width is dominated by Γn, the capture area allows to determine G. Transmission measurements were carried out to determine Γn, and the statistical factor g of resonances. Before performing a Resonance Shape Analysis (RSA) on the transmission and capture data, we verified the neutron flux and resolution at GELINA. We also compared the characteristics of GELINA with those of the n-TOF facility at CERN. A special emphasis is placed on the total energy detection technique using C6D6 detectors. This technique was applied for the determination of the capture cross section. To reduce systematic bias effects on the capture cross section, the response of the detectors was determined by Monte Carlo simulations, which has been validated by experiments. Using these response functions the partial capture cross sections for individual resonances of 206Pb have been deduced, by unfolding the response of the C6D

  6. Interplay among solidification, microstructure, residual strain and hot tearing in B206 aluminum alloy

    International Nuclear Information System (INIS)

    Hot tearing is a complex phenomenon attributed to alloy solidification, microstructure and stress/strain development within a casting. In this research, the conditions associated with the formation of hot tears in B206 aluminum alloy were investigated. Neutron diffraction strain mapping was carried out on three B206 castings with varying levels of titanium (i.e. unrefined, 0.02 and 0.05 wt%). Titanium additions effectively reduced grain size and transformed grain morphology from coarse dendrites to fine globular grains. Further, thermal analysis suggested that grain refinement delayed the onset of dendrite coherency in B206 and therefore enhanced the duration of bulk liquid metal feeding for the refined casting conditions. As a result, the interactive effects of such factors resulted in a more uniform distribution of strain, and subsequent higher resistance to hot tearing for the grain refined castings

  7. Interplay among solidification, microstructure, residual strain and hot tearing in B206 aluminum alloy

    Energy Technology Data Exchange (ETDEWEB)

    D’Elia, F., E-mail: f.delia10@gmail.com [Centre for Near-net-shape Processing of Materials, Ryerson University, 101 Gerrard St. East, Toronto, Ontario, Canada M5B 2K3 (Canada); Ravindran, C. [Centre for Near-net-shape Processing of Materials, Ryerson University, 101 Gerrard St. East, Toronto, Ontario, Canada M5B 2K3 (Canada); Sediako, D. [Canadian Neutron Beam Centre, Chalk River Laboratories, Chalk River, Ontario, Canada K0J 1J0 (Canada)

    2015-01-29

    Hot tearing is a complex phenomenon attributed to alloy solidification, microstructure and stress/strain development within a casting. In this research, the conditions associated with the formation of hot tears in B206 aluminum alloy were investigated. Neutron diffraction strain mapping was carried out on three B206 castings with varying levels of titanium (i.e. unrefined, 0.02 and 0.05 wt%). Titanium additions effectively reduced grain size and transformed grain morphology from coarse dendrites to fine globular grains. Further, thermal analysis suggested that grain refinement delayed the onset of dendrite coherency in B206 and therefore enhanced the duration of bulk liquid metal feeding for the refined casting conditions. As a result, the interactive effects of such factors resulted in a more uniform distribution of strain, and subsequent higher resistance to hot tearing for the grain refined castings.

  8. Source identification of Pb in aerosols at Jeju-do, Korea by using 207Pb/206Pb and 208Pb/206Pb

    International Nuclear Information System (INIS)

    Aerosols and source related materials (fly ash from refuse incinerators, vehicle exhaust and soil) were collected in April, 2002 in the northern areas of Jeju-do, Korea, and the Pb isotopic ratios (207Pb/206Pb and 208Pb/206Pb) of the samples were measured in order to estimate the Pb sources of the aerosols. The Pb isotopic ratios of the aerosols were classified into two groups, depending on the sampling date. One group showed similar Pb isotopic ratios with those of the source related materials, suggesting that the contribution of the regional sources to the aerosols was very large. The other showed different Pb isotopic ratios from those of the regional sources and relatively high Pb isotopic ratios compared to the ratios of the first group. The results suggest that in the continental Asia there seems to be a long range transport of Pb with high ratios in desert sands, which are carried by northwest seasonal winds.(author)

  9. 19 CFR 206.44a - Special rules for conducting investigations under section 421(b) of the Trade Act.

    Science.gov (United States)

    2010-04-01

    ... COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS... business information, on the approved lead authorized applicants in accord with § 206.17(f) within 2... bracketing of confidential business information permitted by § 206.8(c) of this part....

  10. 45 CFR 46.206 - Research involving, after delivery, the placenta, the dead fetus or fetal material.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Research involving, after delivery, the placenta, the dead fetus or fetal material. 46.206 Section 46.206 Public Welfare DEPARTMENT OF HEALTH AND HUMAN... placenta, the dead fetus or fetal material. (a) Research involving, after delivery, the placenta; the...

  11. 75 FR 71183 - 23rd Meeting: RTCA Special Committee 206: EUROCAE WG 76 Plenary: AIS and MET Data Link Services

    Science.gov (United States)

    2010-11-22

    ... Services and a revised Terms of Reference (TOR) for SC-206 has been approved by the RTCA Program Management Committee. A brief description of the document deliverables called out in the revised SC-206 TOR is provided... Architecture Recommendations are included in the TOR deliverables. The Concept of Use for AIS and MET Data...

  12. 75 FR 69861 - Airworthiness Directives; Cessna Aircraft Company (Cessna) 172, 175, 177, 180, 182, 185, 206, 207...

    Science.gov (United States)

    2010-11-16

    ....johnson@faa.gov . SUPPLEMENTARY INFORMATION: Airworthiness Directive 2008-26-10, Amendment 39-15776 (73 FR... Company (Cessna) 172, 175, 177, 180, 182, 185, 206, 207, 208, 210, 303, 336, and 337 Series Airplanes... obstruction is found for certain Cessna 172, 175, 177, 180, 182, 185, 206, 207, 208, 210, 303, 336, and...

  13. 7 CFR 1710.206 - Approval requirements for load forecasts prepared pursuant to approved load forecast work plans.

    Science.gov (United States)

    2010-01-01

    ... pursuant to approved load forecast work plans. 1710.206 Section 1710.206 Agriculture Regulations of the... requirements for load forecasts prepared pursuant to approved load forecast work plans. (a) Contents of load forecasts prepared under an approved load forecast work plan. In addition to the minimum requirements...

  14. 34 CFR 206.1 - What are the special educational programs for students whose families are engaged in migrant and...

    Science.gov (United States)

    2010-07-01

    ... whose families are engaged in migrant and other seasonal farmwork? 206.1 Section 206.1 Education..., DEPARTMENT OF EDUCATION SPECIAL EDUCATIONAL PROGRAMS FOR STUDENTS WHOSE FAMILIES ARE ENGAGED IN MIGRANT AND OTHER SEASONAL FARMWORK-HIGH SCHOOL EQUIVALENCY PROGRAM AND COLLEGE ASSISTANCE MIGRANT PROGRAM...

  15. 25 CFR 161.206 - What must a permittee do to protect livestock from exposure to disease?

    Science.gov (United States)

    2010-04-01

    ... exposure to disease? 161.206 Section 161.206 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR... permittee do to protect livestock from exposure to disease? In accordance with applicable law, permittees... infectious diseases; and (c) Restrict the movement of exposed or infected livestock....

  16. 15 CFR 270.206 - Public briefings and requests for information.

    Science.gov (United States)

    2010-01-01

    ... Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NATIONAL CONSTRUCTION SAFETY TEAMS NATIONAL CONSTRUCTION SAFETY TEAMS Investigations § 270.206 Public briefings and requests... progress of an investigation. Methods may include: (1) A public Web site; (2) Mailing lists, to include...

  17. 17 CFR 275.206(4)-1 - Advertisements by investment advisers.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Advertisements by investment... COMMISSION (CONTINUED) RULES AND REGULATIONS, INVESTMENT ADVISERS ACT OF 1940 § 275.206(4)-1 Advertisements by investment advisers. (a) It shall constitute a fraudulent, deceptive, or manipulative...

  18. 49 CFR 236.206 - Battery or power supply with respect to relay; location.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Battery or power supply with respect to relay..., AND APPLIANCES Automatic Block Signal Systems Standards § 236.206 Battery or power supply with respect to relay; location. The battery or power supply for each signal control relay circuit, where an...

  19. 40 CFR 33.206 - Is there a list of certified MBEs and WBEs?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Is there a list of certified MBEs and... PROTECTION AGENCY PROGRAMS Certification § 33.206 Is there a list of certified MBEs and WBEs? EPA OSDBU will maintain a list of certified MBEs and WBEs on EPA OSDBU's Home Page on the Internet. Any interested...

  20. 42 CFR 50.206 - Sterilization of a mentally incompetent individual or of an institutionalized individual.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Sterilization of a mentally incompetent individual..., DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS POLICIES OF GENERAL APPLICABILITY Sterilization of Persons in Federally Assisted Family Planning Projects § 50.206 Sterilization of a mentally incompetent individual...

  1. 34 CFR 403.206 - What are the State's responsibilities regarding a State occupational information coordinating...

    Science.gov (United States)

    2010-07-01

    ... EDUCATION STATE VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAM What Are the Administrative Responsibilities of a State Under the State Vocational and Applied Technology Education Program? § 403.206 What are... 34 Education 3 2010-07-01 2010-07-01 false What are the State's responsibilities regarding a...

  2. 23 CFR 450.206 - Scope of the statewide transportation planning process.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Scope of the statewide transportation planning process....206 Scope of the statewide transportation planning process. (a) Each State shall carry out a continuing, cooperative, and comprehensive statewide transportation planning process that provides...

  3. 40 CFR 88.206-94 - State opt-in for the California Pilot Test Program.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES California Pilot Test Program § 88.206-94 State opt-in for the California Pilot Test Program. (a) A state may opt into the Pilot program if it contains... 40 Protection of Environment 20 2010-07-01 2010-07-01 false State opt-in for the California...

  4. 77 FR 30584 - Thirtieth Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data...

    Science.gov (United States)

    2012-05-23

    ... report SG3 report SAE G-10 AI ARP Briefing to SC-206 Plenary 12:30 p.m. Review ConUse Changes 12 June.... Closing Plenary SG1 report SG2 report Decision to approve the ConUse document for release to the PMC...

  5. 30 CFR 206.350 - What is the purpose of this subpart?

    Science.gov (United States)

    2010-07-01

    ... MANAGEMENT PRODUCT VALUATION Geothermal Resources § 206.350 What is the purpose of this subpart? (a) This subpart applies to all geothermal resources produced from Federal geothermal leases issued pursuant to the Geothermal Steam Act of 1970 (GSA), as amended by the Energy Policy Act of 2005 (EPAct) (30 U.S.C. 1001...

  6. 19 CFR 206.7 - Confidential business information; furnishing of nonconfidential summaries thereof.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Confidential business information; furnishing of... NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET DISRUPTION, TRADE DIVERSION, AND REVIEW OF RELIEF ACTIONS General § 206.7 Confidential business...

  7. 40 CFR 61.206 - Distribution and use of phosphogypsum for other purposes.

    Science.gov (United States)

    2010-07-01

    ... long term, as disposal of phosphogypsum in a stack or a mine. (d) If the Assistant Administrator for... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Distribution and use of phosphogypsum... Emission Standards for Radon Emissions From Phosphogypsum Stacks § 61.206 Distribution and use...

  8. 30 CFR 206.365 - Does MMS protect information I provide?

    Science.gov (United States)

    2010-07-01

    ... Act regulations of the Department of the Interior at 43 CFR part 2. ... MANAGEMENT PRODUCT VALUATION Geothermal Resources § 206.365 Does MMS protect information I provide? Certain information you submit to MMS regarding royalties or fees on geothermal resources or byproducts,...

  9. 31 CFR 206.10 - Operation of and payments from the Cash Management Improvements Fund.

    Science.gov (United States)

    2010-07-01

    ... SERVICE MANAGEMENT OF FEDERAL AGENCY RECEIPTS, DISBURSEMENTS, AND OPERATION OF THE CASH MANAGEMENT IMPROVEMENTS FUND § 206.10 Operation of and payments from the Cash Management Improvements Fund. (a) The Cash... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Operation of and payments from...

  10. 9 CFR 381.206 - Labeling of shipping containers of poultry products offered for entry.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Labeling of shipping containers of... Imported Poultry Products § 381.206 Labeling of shipping containers of poultry products offered for entry. Shipping containers of imported poultry products are required to bear in a prominent and legible manner...

  11. 9 CFR 203.15 - Trust benefits under sections 206 and 207 of the Act.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Trust benefits under sections 206 and 207 of the Act. 203.15 Section 203.15 Animals and Animal Products GRAIN INSPECTION, PACKERS AND..., live poultry seller or grower, to preserve his interest in the statutory trust, must give...

  12. 24 CFR 983.206 - HAP contract amendments (to add or substitute contract units).

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false HAP contract amendments (to add or... Contract § 983.206 HAP contract amendments (to add or substitute contract units). (a) Amendment to... substitute unit and must determine the reasonable rent for such unit. (b) Amendment to add contract units....

  13. 34 CFR 206.4 - What regulations apply to these programs?

    Science.gov (United States)

    2010-07-01

    ...: (1) 34 CFR part 74 (Administration of Grants to Institutions of Higher Education, Hospitals, and... ENGAGED IN MIGRANT AND OTHER SEASONAL FARMWORK-HIGH SCHOOL EQUIVALENCY PROGRAM AND COLLEGE ASSISTANCE MIGRANT PROGRAM General § 206.4 What regulations apply to these programs? The following regulations...

  14. 24 CFR 206.308 - Continuing education requirements of counselors listed on the HECM Counselor Roster.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Continuing education requirements... LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOME EQUITY CONVERSION MORTGAGE INSURANCE HECM Counselor Roster § 206.308 Continuing education requirements of counselors...

  15. 40 CFR 266.206 - Standards applicable to the treatment and disposal of waste military munitions.

    Science.gov (United States)

    2010-07-01

    ... HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Military Munitions § 266.206 Standards applicable to the treatment and disposal of waste military munitions. The treatment and disposal of hazardous waste military munitions are subject to the applicable permitting, procedural,...

  16. 42 CFR 420.206 - Disclosure of persons having ownership, financial, or control interest.

    Science.gov (United States)

    2010-10-01

    ... this section shall be subject to public disclosure as specified in 20 CFR part 422. ... 42 Public Health 3 2010-10-01 2010-10-01 false Disclosure of persons having ownership, financial... of Ownership and Control Information § 420.206 Disclosure of persons having ownership, financial,...

  17. microRNA-206对人横纹肌肉瘤细胞增殖的影响%Effect of microRNA-206 on proliferation of human rhabdomyosarcoma cells

    Institute of Scientific and Technical Information of China (English)

    陈晓燕; 王教; 王瓯晨

    2009-01-01

    目的 研究microRNA-206在人横纹肌肉瘤细胞A673和A204中的表达以及对细胞增殖的影响.方法 Northern blotting检测正常肌肉组织与人横纹肌肉瘤细胞中microRNA-206表达水平的差异,MTS法检测转染microRNA-206后对细胞增殖的影响.Western blotting检测microRNA-206后对细胞中蛋白水平的影响.结果 Northern blotting结果显示,microRNA-206在正常肌肉组织中高表达,在横纹肌肉瘤细胞A673和A204中不表达;MTS结果表明转染microRNA-206后,横纹肌肉瘤细胞的数目明显减少,microRNA能够明显下调人横纹肌肉瘤细胞中p-ERK的表达.结论 microRNA-206通过ERK信号传导通路抑制横纹肌肉瘤细胞的增殖.

  18. MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D.

    Science.gov (United States)

    Georgantas, Robert W; Streicher, Katie; Luo, Xiaobing; Greenlees, Lydia; Zhu, Wei; Liu, Zheng; Brohawn, Philip; Morehouse, Christopher; Higgs, Brandon W; Richman, Laura; Jallal, Bahija; Yao, Yihong; Ranade, Koustubh

    2014-03-01

    Expression profiling of microRNAs in melanoma lesional skin biopsies compared with normal donor skin biopsies, as well as melanoma cell lines compared with normal melanocytes, revealed that hsa-miR-206 was down-regulated in melanoma (-75.4-fold, P = 1.7 × 10(-4)). MiR-206 has been implicated in a large number of cancers, including breast, lung, colorectal, ovarian, and prostate cancers; however, its role in tumor development remains largely unknown, its biologic function is poorly characterized, and its targets affecting cancer cells are largely unknown. MiR-206 reduced growth and migration/invasion of multiple melanoma cell lines. Bioinformatics identified cell cycle genes CDK2, CDK4, Cyclin C, and Cyclin D1 as strong candidate targets. Western blots and 3'UTR reporter gene assays revealed that miR-206 inhibited translation of CDK4, Cyclin D1, and Cyclin C. Additionally, hsa-miR-206 transfection induced G1 arrest in multiple melanoma cell lines. These observations support hsa-miR-206 as a tumor suppressor in melanoma and identify Cyclin C, Cyclin D1, and CDK4 as miR-206 targets. PMID:24289491

  19. MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D.

    Science.gov (United States)

    Georgantas, Robert W; Streicher, Katie; Luo, Xiaobing; Greenlees, Lydia; Zhu, Wei; Liu, Zheng; Brohawn, Philip; Morehouse, Christopher; Higgs, Brandon W; Richman, Laura; Jallal, Bahija; Yao, Yihong; Ranade, Koustubh

    2014-03-01

    Expression profiling of microRNAs in melanoma lesional skin biopsies compared with normal donor skin biopsies, as well as melanoma cell lines compared with normal melanocytes, revealed that hsa-miR-206 was down-regulated in melanoma (-75.4-fold, P = 1.7 × 10(-4)). MiR-206 has been implicated in a large number of cancers, including breast, lung, colorectal, ovarian, and prostate cancers; however, its role in tumor development remains largely unknown, its biologic function is poorly characterized, and its targets affecting cancer cells are largely unknown. MiR-206 reduced growth and migration/invasion of multiple melanoma cell lines. Bioinformatics identified cell cycle genes CDK2, CDK4, Cyclin C, and Cyclin D1 as strong candidate targets. Western blots and 3'UTR reporter gene assays revealed that miR-206 inhibited translation of CDK4, Cyclin D1, and Cyclin C. Additionally, hsa-miR-206 transfection induced G1 arrest in multiple melanoma cell lines. These observations support hsa-miR-206 as a tumor suppressor in melanoma and identify Cyclin C, Cyclin D1, and CDK4 as miR-206 targets.

  20. Clinical analysis of 206 cases of acute poisoning in children%206例小儿急性中毒的临床分析

    Institute of Scientific and Technical Information of China (English)

    彭庆明; 邹卫红; 郭毅; 贺丽梅

    2014-01-01

    Objective To investigate the etiology and clinical characteristics of pediatric acute poisoning. Methods The clinical data of 206 cases of acute poisoning in children in our hospital were retrospectively analyzed. Results In 206 patients with poisoning,90 cases (43.7%) were food poisoning,45 cases (21.8%) with drug poisoning, 30 cases (14.6%)of pesticide poisoning,18 cases (8.7%) of rodenticide poisoning,12 cases (5.8%)of chemical poisoning,11 cases (5.3%) of CO poisoning;among them 191 cases were cured or improved,6 cases of death, transferred 5 cases,4 cases gave up treatment. Conclusion Pediatric acute poisoning involving children of all ages,the number of rural areas is more than urban,and most of the digestive tract poisoning,to eating, wrongly as much;prevention and treatment of acute poisoning in children should be based on prevention,treatment time is the key to treatment of acute poisoning.%目的:了解小儿急性中毒的病因及临床特点。方法回顾性分析对本院206例急性中毒患儿的临床资料。结果在206例中毒患儿中,食物中毒90例(43.7%),药物中毒45例(21.8%),农药中毒30例(14.6%),鼠药中毒18例(8.7%),化学品中毒12例(5.8%),CO中毒11例(5.3%);其中治愈好转191例,死亡6例,转院5例,放弃治疗4例。结论小儿急性中毒涉及儿童各年龄段,农村多于城镇,且绝大多数经消化道中毒,以误食、误服为多;小儿急性中毒的防治应以预防为主,救治开始时间是急性中毒抢救治疗的关键。

  1. 基于FSL206MR的离线式开关电源设计%Design of offline switch mode power based on FSL206MR

    Institute of Scientific and Technical Information of China (English)

    汤永科; 王勇; 王小亮; 秦磊

    2014-01-01

    The paper introduces a design of offline switch mode power based on the power supply chip FSL206MR which integrates pulse width modulator(PWM)and SenseFET. It analyzes the working process and design program of the feedback circuit and buck topology in detail. The feedback network is composed of NPN transistor MMBT222A and voltage regulator diode BZX84C13. This switch mode power performs well and has many advantages, such as the simple structure, a good result of voltage stabilization and easy encapsulation, so it has the very high value in application.%介绍了一种基于集成 PWM 和 SenseFET 的开关电源芯片 FSL206MR 的离线式开关电源设计,详细分析了反馈电路和降压拓扑的工作过程及设计方案。采用 NPN 晶体三极管 MMBT2222A 和稳压管 BZX84C13组成反馈网络。该开关电源性能优良,具有结构简单、稳压效果好、易封装等优点,具有很高的生产应用价值。

  2. Design of offline switch mode power based on FSL206MR%基于FSL206MR的离线式开关电源设计

    Institute of Scientific and Technical Information of China (English)

    汤永科; 王勇; 王小亮; 秦磊

    2014-01-01

    The paper introduces a design of offline switch mode power based on the power supply chip FSL206MR which integrates pulse width modulator(PWM)and SenseFET. It analyzes the working process and design program of the feedback circuit and buck topology in detail. The feedback network is composed of NPN transistor MMBT222A and voltage regulator diode BZX84C13. This switch mode power performs well and has many advantages, such as the simple structure, a good result of voltage stabilization and easy encapsulation, so it has the very high value in application.%介绍了一种基于集成 PWM 和 SenseFET 的开关电源芯片 FSL206MR 的离线式开关电源设计,详细分析了反馈电路和降压拓扑的工作过程及设计方案。采用 NPN 晶体三极管 MMBT2222A 和稳压管 BZX84C13组成反馈网络。该开关电源性能优良,具有结构简单、稳压效果好、易封装等优点,具有很高的生产应用价值。

  3. Coulomb excitation of the two proton-hole nucleus $^{206}$Hg

    CERN Multimedia

    We propose to use Coulomb excitation of the single magic two-proton-hole nucleus $^{206}$Hg. In a single-step excitation both the first 2$^{+}$ and the highly collective octupole 3$^{-}$ states will be populated. Thus, information on both quadrupole and octupole collectivity will be gained in this neutron-rich nucleus. Due to the high beam intensity, we will be able to observe multi-step Coulomb excitation as well, providing further test on theoretical calculations. The results will be used to improve the predictive power of the shell model for more exotic nuclei as we move to lighter N=126 nuclei. The experiment will use the new HIE-ISOLDE facility and the MINIBALL array, and will take advantage of the recently developed $^{206}$Hg beam from the molten lead target.

  4. Photolysis of organic pollutants in wastewater with 206 nm UV irradiation

    Institute of Scientific and Technical Information of China (English)

    Zhao Lian Ye; Chang Qing Cao; Jin Cong He; Ren Xi Zhang; Hui Qi Hou

    2009-01-01

    A new-type UV light source (206 nm) was explored for the degradation of organic pollutants in wastewater for the first time. The degradation performances of triphenyltin chloride (TPTC1), dimethyl phthalate (DMP), as well as rhodamine B (RhB) were investigated. The results indicated that removal efficiency of 50 mg/L RhB, 60 mg/L DMP and 120 mg/LTPTC1 can reach 88.6%,92.5% and 89.4% for 60 min, 50 min and 75 min, respectively. By comparison of removal efficiency, we found 206 nm is superior to 253.7 nm UV in wastewater treatment, implying it is an effective, promising, and worthwhile exploring technology to decompose organic pollutants in wastewater.

  5. Tensile Properties of Al-Cu 206 Cast Alloys with Various Iron Contents

    Science.gov (United States)

    Liu, K.; Cao, X.; Chen, X.-G.

    2014-05-01

    The Al-Cu 206 cast alloys with varying alloy compositions ( i.e., different levels of Fe, Mn, and Si) were investigated to evaluate the effect of the iron-rich intermetallics on the tensile properties. It is found that the tensile strength decreases with increasing iron content, but its overall loss is less than 10 pct over the range of 0.15 to 0.5 pct Fe at 0.3 pct Mn and 0.3 pct Si. At similar iron contents, the tensile properties of the alloys with dominant Chinese script iron-rich intermetallics are generally higher than those with the dominant platelet phase. In the solution and artificial overaging condition (T7), the tensile strength of the 206 cast alloys with more than 0.15 pct Fe is satisfactory, but the elongation does not sufficiently meet the minimum requirement of ductility (>7 pct) for critical automotive applications. However, it was found that both the required ductility and tensile strength can be reached at high Fe levels of 0.3 to 0.5 pct for the alloys with well-controlled alloy chemistry and microstructure in the solution and natural aging condition (T4), reinforcing the motivation for developing recyclable high-iron Al-Cu 206 cast alloys.

  6. XMM-Newton view of the N 206 superbubble in the Large Magellanic Cloud

    CERN Document Server

    Kavanagh, Patrick J; Points, Sean D

    2012-01-01

    We perform an analysis of the X-ray superbubble in the N 206 HII region in the Large Magellanic Cloud using current generation facilities to gain a better understanding of the physical processes at work in the superbubble and to improve our knowledge of superbubble evolution. We used XMM-Newton observations of the N 206 region to produce images and extract spectra of the superbubble diffuse emission. Morphological comparisons with Halpha images from the Magellanic Cloud Emission Line Survey were performed, and spectral analysis of the diffuse X-ray emission was carried out. We derived the physical properties of the hot gas in the superbubble based on the results of the spectral analysis. We also determined the total energy stored in the superbubble and compared this to the expected energy input from the stellar population to assess the superbubble growth rate discrepancy for N 206. We find that the brightest region of diffuse X-ray emission is confined by a Halpha shell, consistent with the superbubble model....

  7. miR-206-3p在小鼠皮肤中的表达及其作用%Expression and distribution of miR-206-3p in mouse skin and its potential roles

    Institute of Scientific and Technical Information of China (English)

    穆原; 周红; 李文艳; 李耀武

    2013-01-01

    Objective To investigate the expression and distribution of miR-206-3p and its target gene Bdnf (brain-derived neurotrophic factor) in mouse skin and the potential roles during the development of skin.Methods The full-thickness back skins of BALB/c mice on the 13.5 dpc (day post coition),15.5 dpc,17.5 dpc,1 dpp (day post partum),4 dpp and 16 weeks were collected respectively.The expression levels of miR-206-3p and BdnfmRNA were measured by real time RT-PCR,and BDNF protein was detected by western blot.The distributions of miR-206-3p and BDNF in tissue were profiled by in situ hybridization (ISH) and immunohistochemistry (IHC) respectively.Results The expression level of miR-206-3p increased gradually until 17.5 dpc and subsequently receded to the similar level of the 13.5 dpc during adult stage.The expression of BDNF protein exhibited in the opposite manner of miR-206-3p but BdnfmRNA remained stable from the 17.5 dpc until adult stage.ISH results showed that the distribution of miR-206-3p was gradually regionalized during the development of skin in the postnatal days and mainly located in the suprabasal layer and periphery of hair follicles,which was adjacent to the regions of BDNF expression at the same stage in a nonoverlapping manner.Conclusion The miR-206-3p may be involved in neurodevelopment of mouse skin through the post-transcriptional regulation of Bdnf.%目的 对小鼠皮肤中miR-206-3p及其靶基因脑源性神经营养因子(Bdnf)进行表达与定位检测,以探讨其在皮肤发育过程中的可能作用.方法 手术剪取13.5 dpc(交配后天数)、15.5 dpc、17.5 dpc胎鼠,1 dpp(出生后天数)、4 dpp乳鼠及16周龄雄鼠的背部全层皮肤,用实时荧光定量RT-PCR检测miR-206-3p与Bdnf mRNA的表达水平,western blot检测BDNF蛋白质表达水平,原位杂交与免疫组化分别检测miR-206-3p与BDNF的组织定位.结果 皮肤中miR-206-3p在胚胎期持续升高,到17.5 dpc后逐渐降低,于成年鼠时回复至13.5 dpc时

  8. Breeding and selection of jackfruit Yunre-206%菠萝蜜优良单株云热-206的选育研究

    Institute of Scientific and Technical Information of China (English)

    尼章光; 张林辉; 解德宏; 罗心平; 文定良; 俞艳春

    2008-01-01

    介绍了菠萝蜜优良单株云热-206的选育过程及其特征特性.该单株的产量、品质均优于其他单株及当地种植群体,果实椭圆形、中等大,平均单果重2 233.0 g,果皮青绿色;种子长2.957 cm、宽2.052 cm,每公斤果实的种子数较少(40.9粒);成熟时果苞金黄色,果苞长3.951 cm、宽3.256 cm,果苞重比率为72.40%,果苞清香味浓,综合性状优良.

  9. Higgs Candidates in $e^+ e^-$ Interactions at $\\sqrt{s}$= 206.6 GeV

    CERN Document Server

    Acciarri, M; Adriani, O; Aguilar-Benítez, M; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Bajo, A; Baksay, L; Balandras, A; Baldew, S V; Todorova-Nová, S; Banerjee, Sw; Barczyk, A; Barillère, R; Bartalini, P; Basile, M; Batalova, N; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Bellucci, L; Berbeco, R; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Bhattacharya, S; Biasini, M; Biland, A; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böhm, A; Boldizsar, L; Borgia, B; Bourilkov, D; Bourquin, Maurice; Braccini, S; Branson, J G; Brochu, F; Buffini, A; Buijs, A; Burger, J D; Burger, W J; Cai, X D; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chang, Y H; Chaturvedi, U K; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chiefari, G; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Coignet, G; Colino, N; Costantini, S; Cotorobai, F; de la Cruz, B; Csilling, Akos; Cucciarelli, S; Dai, T S; van Dalen, J A; D'Alessandro, R; De Asmundis, R; Déglon, P L; Degré, A; Deiters, K; Della Volpe, D; Delmeire, E; Denes, P; De Notaristefani, F; De Salvo, A; Diemoz, M; Dierckxsens, M; Van Dierendonck, D N; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dova, M T; Duchesneau, D; Dufournaud, D; Duinker, P; Durán, I; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Ewers, A; Extermann, Pierre; Fabre, M; Falagán, M A; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, Marta; Ferguson, T; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Fisk, I; Forconi, G; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gataullin, M; Gau, S S; Gentile, S; Gheordanescu, N; Giagu, S; Gong, Z F; Grenier, G; Grimm, O; Grünewald, M W; Guida, M; van Gulik, R; Gupta, V K; Gurtu, A; Gutay, L J; Haas, D; Hasan, A; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Hidas, P; Hirschfelder, J; Hofer, H; Holzner, G; Hoorani, H; Hou, S R; Hu, Y; Iashvili, I; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Khan, R A; Käfer, D; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, J K; Kirkby, Jasper; Kiss, D; Kittel, E W; Klimentov, A; König, A C; Kopal, M; Kopp, A; Koutsenko, V F; Kräber, M H; Krämer, R W; Krenz, W; Krüger, A; Kunin, A; Ladrón de Guevara, P; Laktineh, I; Landi, G; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee, H J; Le Goff, J M; Leiste, R; Levchenko, P M; Li Chuan; Likhoded, S A; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Lugnier, L; Luminari, L; Lustermann, W; Ma Wen Gan; Maity, M; Malgeri, L; Malinin, A; Maña, C; Mangeol, D J J; Mans, J; Marian, G; Martin, J P; Marzano, F; Mazumdar, K; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Von der Mey, M; Mihul, A; Milcent, H; Mirabelli, G; Mnich, J; Mohanty, G B; Moulik, T; Muanza, G S; Muijs, A J M; Musicar, B; Musy, M; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Niessen, T; Nisati, A; Nowak, H; Ofierzynski, R A; Organtini, G; Oulianov, A; Palomares, C; Pandoulas, D; Paoletti, S; Paolucci, P; Paramatti, R; Park, H K; Park, I H; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Pedace, M; Pensotti, S; Perret-Gallix, D; Petersen, B; Piccolo, D; Pierella, F; Pieri, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Pothier, J; Prokofiev, D O; Prokofev, D; Quartieri, J; Rahal-Callot, G; Rahaman, M A; Raics, P; Raja, N; Ramelli, R; Rancoita, P G; Ranieri, R; Raspereza, A V; Raven, G; Razis, P A; Ren, D; Rescigno, M; Reucroft, S; Riemann, S; Riles, K; Rodin, J; Roe, B P; Romero, L; Rosca, A; Rosier-Lees, S; Roth, S; Rosenbleck, C; Rubio, Juan Antonio; Ruggiero, G; Rykaczewski, H; Saremi, S; Sarkar, S; Salicio, J; Sánchez, E; Sanders, M P; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schopper, Herwig Franz; Schotanus, D J; Schwering, G; Sciacca, C; Seganti, A; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shumilov, E; Shvorob, A V; Siedenburg, T; Son, D; Smith, B; Spillantini, P; Steuer, M; Stickland, D P; Stone, A; Stoyanov, B; Strässner, A; Sudhakar, K; Sultanov, G G; Sun, L Z; Sushkov, S V; Suter, H; Swain, J D; Szillási, Z; Sztaricskai, T; Tang, X W; Tauscher, Ludwig; Taylor, L; Tellili, B; Timmermans, C; Ting, Samuel C C; Ting, S M; Tonwar, S C; Tóth, J; Tully, C; Tung, K L; Uchida, Y; Ulbricht, J; Valente, E; Vesztergombi, G; Vetlitskii, I; Vicinanza, D; Viertel, Gert M; Villa, S; Vivargent, M; Vlachos, S; Vodopyanov, I; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vorvolakos, A; Wadhwa, M; Wallraff, W; Wang, M; Wang, X L; Wang, Z M; Weber, A; Weber, M; Wienemann, P; Wilkens, H; Wu, S X; Wynhoff, S; Xia, L; Xu, Z Z; Yamamoto, J; Yang, B Z; Yang, C G; Yang, H J; Yang, M; Ye, J B; Yeh, S C; Zalite, A; Zalite, Yu; Zhang, Z P; Zhu, G Y; Zhu, R Y; Zichichi, A; Zilizi, G; Zimmermann, B; Zöller, M

    2000-01-01

    In a search for the Standard Model Higgs boson, carried out on 212.5~$\\mathrm{pb^{-1}}$ of data collected by the L3 detector at the highest LEP centre-of-mass energies, including 116.5~$\\mathrm{pb^{-1}}$ above $\\sqrt{s} = 206$~GeV, an excess of candidates for the process $e^+ e^- \\rightarrow Z^{*}\\rightarrow HZ$ is found for Higgs masses near 114.5~GeV. We present an analysis of our data and the characteristics of our strongest candidates.

  10. Mechanism of Regulatory Effect of MicroRNA-206 on Connexin 43 in Distant Metastasis of Breast Cancer

    Institute of Scientific and Technical Information of China (English)

    Zi-Jing Lin; Jia Ming; Lu Yang; Jun-Ze Du; Ning Wang; Hao-Jun Luo

    2016-01-01

    Background: MicroRNA-206 (miR-206) and connexin 43 (Cx43) are related with the distant metastasis of breast cancer.It remains unclear whether the regulatory effect of miR-206 on Cx43 is involved in metastasis of breast cancer.Methods: Using quantitative real-time polymerase chain reaction and Western blot, the expressions of miR-206 and Cx43 were determined in breast cancer tissues, hepatic and pulmonary metastasis (PM), and cell lines (MCF-10A, MCF-7, and MDA-MB-231).MCF-7/MDA-M-231 cells were transfected with lentivirus-shRNA vectors to enhance/inhibit miR-206, and then Cx43 expression was observed.Cell counting kit-8 assay and Transwell method were used to detect their changes in proliferation, migration, and invasion activity.The mutant plasmids of Cx43-3' untranslated region (3'UTR) at position 478-484 and position 1609-1615 were constructed.Luciferase reporter assay was performed to observe the effects of miR-206 on luciferase expression of different mutant plasmids and to confirm the potential binding sites of Cx43.Results: Cx43 protein expression in hepatic and PM was significantly higher than that in the primary tumor, while no significant difference was showed in messenger RNA (mRNA) expression.MiR-206 mRNA expression in hepatic and PM was significantly lower than that in the primary tumor.Cx43 mRNA and protein levels, as well as cell proliferation, migration, and invasion capabilities, were all significantly improved in MDA-MB-231 cells after reducing miR-206 expression but decreased in MCF-7 cells after elevating miR-206 expression, which demonstrated a significantly negative correlation between miR-206 and Cx43 expression (P =0.03).MiR-206 can drastically decrease Cx43 expression of MCF-7 cells but exerts no effects on Cx43 expression in 293 cells transfected with the Cx43 coding region but the lack of Cx43-3'UTR, suggesting that Cx43-3'UTR may be the key in Cx43 regulated by miR-206.Luciferase expression showed that the inhibition efficiency was

  11. Processing and geologic analysis of conventional cores from well ER-20-6 No. 1, Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Prothro, L.B., Townsend, M.J.; Drellack, S.L. Jr. [and others

    1997-09-01

    In 1996, Well Cluster ER-20-6 was drilled on Pahute Mesa in Area 20, in the northwestern corner of the Nevada Test Site (NTS). The three wells of the cluster are located from 166 to 296 meters (m) (544 to 971 feet [ft]) southwest of the site of the underground nuclear test code-named BULLION, conducted in 1990 in Emplacement Hole U-20bd. The well cluster was planned to be the site of a forced-gradient experiment designed to investigate radionuclide transport in groundwater. To obtain additional information on the occurrence of radionuclides, nature of fractures, and lithology, a portion of Well ER-20-6 No. 1, the hole closest to the explosion cavity, was cored for later analysis. Bechtel Nevada (BN) geologists originally prepared the geologic interpretation of the Well Cluster ER-20-6 site and documented the geology of each well in the cluster. However, the cores from Well ER-20-6 No. 1 were not accessible at the time of that work. As the forced-gradient experiment and other radio nuclide migration studies associated with the well cluster progressed, it was deemed appropriate to open the cores, describe the geology, and re-package the core for long-term air-tight storage. This report documents and describes the processing, geologic analysis, and preservation of the conventional cores from Well ER20-6 No. 1.

  12. LN206井P110油管的腐蚀原因%Corrosion Reason of P110 Tubing Used in LN206 Well

    Institute of Scientific and Technical Information of China (English)

    毛学强; 谢俊峰; 宋文文; 周怀光; 赵密锋; 陈洪

    2013-01-01

    Severe corrosion occurred at thread joint between submersible pump and spill valve of P110 in LN206 well tubing after 43 days service.The reason of the corrosion failure was studied by metallographic examination,chemical composition analysis,and electrochemical test.The results indicated that to the tubing material,no abnormal phase was found according to micro-morphology observation chemical composition met the requirement of API Spec 5CT.The surface damage was observed on the thread,so the corrosive medium go into the crevice at the damage area.The electrochemical test results show that the potential difference between oil well tubing and spill valve is approximately 110 mV.It is concluded that the corrosion was mainly caused by crevice corrosion,galvanic corrosion,and the high concentration of Cl-accelerated the corrosion process.It is suggested to avoid thread damage during joining the oil well tubing and spill valve.It is necessary thread grease to fully fill the crevice between oil well tubing and spill valve avoid the direct contact of dissimilar metals with significant potential difference.%LN206井中P110油管与潜油泵出口处连接泄油阀的丝扣仅使用了43 d就发生严重腐蚀,对其进行了金相、化学分析和腐蚀电位测试.结果表明,油管的金相组织无异常,化学成分符合API Spec 5CT要求;且油管与泄油阀连接的丝扣有损伤现象,存在一定的缝隙,高浓度的Cl促进了腐蚀;油管的铬含量与泄油阀的相差较大,油管与泄油阀间的电位相差约110mV,电偶腐蚀加速丝扣处腐蚀.建议上扣时避免油管与泄油阀两者连接的丝扣发生损伤,并在丝扣上涂抹质量好的螺纹脂将两者丝扣间的缝隙填满,避免电位相差较大的异种材质直接连接.

  13. Screening of retinopathy in 206 prematurity in Jiaxing%嘉兴市206例早产儿视网膜病变筛查分析

    Institute of Scientific and Technical Information of China (English)

    濮清岚; 周向明; 孙琪; 王虹; 李萍

    2013-01-01

    目的 了解嘉兴市早产儿视网膜病变(ROP)的发病情况.方法 回顾分析在本院出生的ROP的发病率及其特点.结果 接受筛查的早产儿共206例,发生ROP病变16例,均为双眼发病,发病率为7.77%;出生体质量≤1 000 g组、~1 500 g组、~2 000 g组间,发病率差异有统计学意义(χ2=10.37,P0.05)、出生方式(χ2=2.68,P>0.05)、多胎与单胎(χ2=0.21,P>0.05)间发生ROP的发病率,差异无统计学意义.结论 嘉兴市ROP的发病率为7.77%,低出生体质量、低出生胎龄、吸氧、机械通气是ROP发病的重要因素.%Objective To investigate the incidence of retinopathy of prematurity (ROP) in Jiaxing. Methods The records of premature infants who had undergone ROP screening in the maternal and child health care hospital of Jiaxing between January 2011 and December 2011 were reviewed and analyzed. Results A total of 206 premature infants who were less than 34 weeks or whose birth weight ≤2 000 g were treated in NICU. They were screened for ROP until the retina was entirely vascularized. The prevalence of ROP in the study was 7. 77% , the prevalence of ROP in the subgroup with birth weight ≤ 1 000 g was significantly higher than that of the subgroup with weight from 1 000 to 1 500 g and that of the subgroup with birth weight from 1 500 to 2 000 g (x2= 10. 37, P 34 weeks) (x2=29. 66,P 0. 05) ,mode of parturition( x2= 2. 68, P > 0. 05 ) , multiple gestational births or single gestational birth ( x2= 0. 21, P > 0. 05 ) . Conclusions The incidence of ROP was 7. 77% in Jiaxing. Shorter gestational age, lower birth weight, oxygen supplementation and mechanical ventilation were main factors leading to ROP incidence.

  14. Fatores que influenciaram a evolução de 206 pacientes com traumatismo craniencefálico grave Relevant factors in 206 patients with severe head injury

    Directory of Open Access Journals (Sweden)

    Venâncio Pereira Dantas Filho

    2004-06-01

    Full Text Available A busca de fatores prognósticos para o traumatismo craniencefálico (TCE tem sido alvo de muitos estudos nas últimas décadas. A identificação de indicadores consistentes da evolução destes pacientes tem representado um grande desafio e sua utilidade considerada evidente tanto para orientar o tratamento, quanto para a estimativa do resultado final. Baseados numa casuística de 206 pacientes com TCE grave (8 pontos ou menos pela Escala de Coma de Glasgow - ECG, estudamos a influência de vários fatores sobre a evolução dos pacientes. A gravidade inicial medida pela ECG, a presença de hipertensão intracraniana (níveis acima de 20 mmHg, o tipo de lesão intracraniana e a presença de hipoxia, hipotensão arterial e a associação de hipóxia e hipotensão arterial tiveram influência significativa sobre a evolução dos pacientes. A presença de politraumatismo (pelo menos dois sítios de lesão além do TCE e a idade (acima e abaixo de 40 anos não influenciaram significativamente a evolução dos pacientes desta casuística.The search for head injury prognostic factors has been intense in the last decades. The importance of identification of these factors has been also recognised to treatment orientation and results estimatives. Based on 206 severe head injuried patients series, we analized the influence of factors over the outcome. The initial severity by Glasgow coma scale, the presence of intracranial hypertension (over 20 mmHg, the type of intracranial lesion and the presence of hypoxia, systemic hypotension or both, significantly influenced the results. The presence of multiple traumas (at least two sites of lesion over head injury, as age, did not influence the final results in this series.

  15. COL Application Content Guide for HTGRs: Revision to RG 1.206, Part 1 - Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Wayne Moe

    2012-08-01

    A combined license (COL) application is required by the Nuclear Regulatory Commission (NRC) for all proposed nuclear plants. The information requirements for a COL application are set forth in 10 CFR 52.79, “Contents of Applications; Technical Information in Final Safety Analysis Report.” An applicant for a modular high temperature gas-cooled reactor (HTGR) must develop and submit for NRC review and approval a COL application which conforms to these requirements. The technical information necessary to allow NRC staff to evaluate a COL application and resolve all safety issues related to a proposed nuclear plant is detailed and comprehensive. To this, Regulatory Guide (RG) 1.206, “Combined License Applications for Nuclear Power Plants” (LWR Edition), was developed to assist light water reactor (LWR) applicants in incorporating and effectively formatting required information for COL application review (Ref. 1). However, the guidance prescribed in RG 1.206 presumes a LWR design proposal consistent with the systems and functions associated with large LWR power plants currently operating under NRC license.

  16. Measurement of the radiative neutron capture cross section of 206Pb and its astrophysical implications

    CERN Document Server

    Domingo-Pardo, C; Aerts, G; Alvarez, H; Alvarez-Velarde, F; Andriamonje, Samuel A; Andrzejewski, J; Assimakopoulos, Panayiotis; Audouin, L; Badurek, G; Baumann, P; Becvar, F; Berthoumieux, E; Bisterzo, S; Calviño, F; Calviani, M; Cano-Ott, D; Capote, R; Carrapico, C; Cennini, P; Chepel, V; Chiaveri, Enrico; Colonna, N; Cortés, G; Couture, A; Cox, J; Dahlfors, M; David, S; Dillman, I; Dolfini, R; Dridi, W; Durán, I; Eleftheriadis, C; Embid-Segura, M; Ferrant, L; Ferrari, A; Ferreira-Marques, R; Fitzpatrick, L; Frais-Kölbl, H; Fujii, K; Furman, W; Gallino, R; Gonçalves, I; Gonzalez-Romero, E; Goverdovski, A; Gramegna, F; Griesmayer, E; Guerrero, C; Gunsing, F; Haas, B; Haight, R; Heil, M; Herrera-Martínez, A; Igashira, M; Isaev, M; Jericha, E; Kappeler, F; Kadi, Y; Karadimos, D; Karamanis, D; Kerveno, M; Ketlerov, V; Köhler, P; Konovalov, V; Kossionides, E; Krticka, M; Lamboudis, C; Leeb, H; Lindote, A; Lopes, I; Lozano, M; Lukic, S; Marganiec, J; Marrone, S; Massimi, C; Mastinu, P; Mengoni, A; Milazzo, P M; Moreau, C; Mosconi, M; Neves, F; Oberhummer, Heinz; Oshima, M; O'Brien, S; Pancin, J; Papachristodoulou, C; Papadopoulos, C; Paradela, C; Patronis, N; Pavlik, A; Pavlopoulos, P; Perrot, L; Plag, R; Plompen, A; Plukis, A; Poch, A; Pretel, C; Quesada, J; Rauscher, T; Reifarth, R; Rosetti, M; Rubbia, Carlo; Rudolf, G; Rullhusen, P; Salgado, J; Sarchiapone, L; Savvidis, I; Stéphan, C; Tagliente, G; Taín, J L; Tassan-Got, L; Tavora, L; Terlizzi, R; Vannini, G; Vaz, P; Ventura, A; Villamarín, D; Vincente, M C; Vlachoudis, V; Vlastou, R; Voss, F; Walter, S; Wendler, H; Wiescher, M; Wisshak, K

    2007-01-01

    The (n, gamma) cross section of 206Pb has been measured at the CERN n_TOF facility with high resolution in the energy range from 1 eV to 600 keV by using two optimized C6D6 detectors. In the investigated energy interval about 130 resonances could be observed, from which 61 had enough statistics to be reliably analyzed via the R-matrix analysis code SAMMY. Experimental uncertainties were minimized, in particular with respect to (i) angular distribution effects of the prompt capture gamma-rays, and to (ii) the TOF-dependent background due to sample-scattered neutrons. Other background components were addressed by background measurements with an enriched 208Pb sample. The effect of the lower energy cutoff in the pulse height spectra of the C6D6 detectors was carefully corrected via Monte Carlo simulations. Compared to previous 206Pb values, the Maxwellian averaged capture cross sections derived from these data are about 20% and 9% lower at thermal energies of 5 keV and 30 keV, respectively. These new results hav...

  17. YOUNG STELLAR OBJECTS IN THE LARGE MAGELLANIC CLOUD STAR-FORMING REGION N206

    International Nuclear Information System (INIS)

    We present analysis of the energetic star-forming region Henize 206 (N206) located near the southern edge of the Large Magellanic Cloud (LMC) based on photometric data from the Spitzer Surveying the Agents of Galaxy Evolution (SAGE-LMC; IRAC 3.6, 4.5, 5.8, 8.0 μm and MIPS 24 μm), Infrared Survey Facility near-infrared survey (J, H, Ks ), and the Magellanic Clouds Photometric Survey (MCPS UBVI) covering a wavelength range of 0.36-24 μm. Young stellar object (YSO) candidates are identified based upon their location in infrared color-magnitude space and classified by the shapes of their spectral energy distributions in comparison with a pre-computed grid of YSO models. We identify 116 YSO candidates: 102 are well characterized by the YSO models, predominately Stage I, and 14 may be multiple sources or young sources with transition disks. Careful examination of the individual sources and their surrounding environment allows us to identify a factor of ∼14.5 more YSO candidates than have already been identified. The total mass of these well-fit YSO candidates is ∼520 Msun. We calculate a current star formation rate of 0.27 x 10-1 Msun yr-1 kpc-2. The distribution of YSO candidates appears to follow shells of neutral material in the interstellar medium.

  18. $^{206}$ Po sources for production and release studies relevant for high power spallation targets

    CERN Multimedia

    The knowledge of the evaporation behaviour of Po is of essential importance for several scientific and technological applications, like accelerator driven systems (ADS) or the LIEBE project at CERN-ISOLDE. Fundamental investigations on the experimental conditions for the formation of volatile Po species as well as on the chemical composition of the volatile compounds are necessary for a safe operation of such facilities. $^{206}$Po, a mainly $\\gamma$- ray-emitting Po isotope with a half-life of 8.8 d, is best suited for model studies, due to the lower radiation hazard compared to the longer-lived $\\alpha$-emitting isotopes $^{208-210}$Po as well as the easy-to-measure $\\gamma$-ray emission. We propose the production of $^{206}$Po samples in several matrices via the implantation of its precursor $^{210}$Fr into selected metal foils at CERN-ISOLDE. Using these samples, experiments will be carried out at PSI studying the volatilization of Po from different matrices under varying chemical conditions.

  19. A novel missense (M206K STAT3 mutation in diffuse large B cell lymphoma deregulates STAT3 signaling.

    Directory of Open Access Journals (Sweden)

    Guangzhen Hu

    Full Text Available Persistent STAT3 activation has been found in activated B-cell like diffuse large B cell tumors (DLBCL. To investigate whether genetic mutations play a role in aberrant STAT3 signaling in DLBCL, we bi-directionally sequenced all 24 exons of the STAT3 gene in DLBCL tumors (n = 40. We identified 2 novel point mutations in 2 separate (2/40; 5% patients at exon 7 and 24. Point mutation 2552G>A was a silent mutation in the stop codon. Another heterozygous mutation 857T>A encoded a methionine substitution by lysine at codon 206 (M206K in the coiled-coil domain of STAT3. We performed site directed mutagenesis to mutate wild type (WT STAT3α and STAT3β at codon 206 and constructed stable cell lines by lentiviral transfection of STAT3α(WT, STAT3α(M206K, STAT3β(WT and STAT3β(M206K plasmids. The mutation was found to increase STAT3 phosphorylation in STAT3α mutant cell lines with no effect on the STAT3β mutant cell line. Transcriptional activation was also increased in the STAT3α mutant cells compared with STAT3α WT cells as detected by a luciferase reporter assay. Moreover, STAT3α(M206K mutant cells were resistant to JAK2 pathway inhibition compared to STAT3α WT cells. These results indicate that missense mutations in STAT3 increase signaling through the JAK/STAT pathway. JAK2 inhibitors may be useful in the patient with this STAT3 mutation as well as those with pathway activation by other mechanisms.

  20. 耐酸性气体腐蚀水泥添加剂DC206的研制及性能评价%Development and Its Performance Evaluation of Cement Additive DC206 to Acid Gas Corrosion

    Institute of Scientific and Technical Information of China (English)

    周仕明; 谭春勤

    2011-01-01

    In order to meet the requirement of exploration and development in acid oil and gas fields, the DC206 inhibitor was developed based on systematical analysis of corrosive mechanism of CO2 and H2 S to cement under wet environment. The indoor experiment showed that cement mixed with DC206 can effectively control the strengthen loss and the increase of permeability after CO2 or H2S corrosion for 21 days. By analyzing the corrosive products and microstructure of set cement, the main mechanism of DC206 is believed to be the reaction with Ca(OH)2 of set cement to reduce the alkalinity. The corrosion rate is reduced significantly under CO2 or H2 S environment. Under CO2 environment, DC206 can help the corrosion product CaCO3 to generate calcite crystal, which raises the strength of cement and reduces the permeability by tight crystal arrangement of calcite. Under H2 S environment, because DC206 consumes Ca(OH)2 which is produced from cement hydration, it prevents the generation of expansive CaSO4 · 2H2 O which reduces the crack and lowers the permeability of set cement.%为了满足酸性油气田勘探开发的需要,在系统分析CO2和H2S在湿环境下腐蚀水泥石机理的基础上,开发了DC206防腐蚀剂.室内性能评价试验表明,在常规水泥浆中加入DC206,经CO2或H2S腐蚀21 d后,水泥石的强度损失和渗透率增高趋势得到有效抑制,与基本水泥相比有较大改善.通过分析腐蚀产物和水泥石微观结构可知,DC206的主要作用机理是:DC206首先消耗掉水泥石中的Ca(OH)2,降低了水泥石碱度,使水泥石在CO2和H2S环境下的腐蚀反应速度大大降低;在CO2腐蚀环境下DC206能够有利于腐蚀产物CaCO3转向方解石结晶,而方解石的晶体排列紧密,可提高水泥石强度,降低其渗透率;在H2S腐蚀环境下,由于DC206消耗掉水泥水化产生的Ca(OH)2,使H2S不能直接与Ca(OH)2反应生成具有膨胀作用的二水石膏,从而能减少水泥石中的裂纹,降低渗透率.

  1. 22 CFR 206.4 - Procedure where a decision concerning a demand is not made prior to the time a response to the...

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Procedure where a decision concerning a demand is not made prior to the time a response to the demand is required. 206.4 Section 206.4 Foreign... prior to the time a response to the demand is required. If the response to the demand is required...

  2. 30 CFR 206.366 - What is the nominal fee that a State, tribal, or local government lessee must pay for the use of...

    Science.gov (United States)

    2010-07-01

    ..., or local government lessee must pay for the use of geothermal resources? 206.366 Section 206.366... government lessee must pay for the use of geothermal resources? If a State, tribal, or local government... or generation of electricity—the State, tribal, or local government lessee must pay a nominal fee....

  3. 18 CFR Appendix I to Subpart F of... - Procedures for Compliance With the Endangered Species Act of 1973 Under § 157.206(b)(3)(i)

    Science.gov (United States)

    2010-04-01

    ... CFR 402.02. The certificate holder shall be deemed in compliance with § 157.206(b)(2)(vi) of the... appropriate) as determined pursuant to 50 CFR 402.01 for the purpose of initiating informal consultations. 2... Compliance With the Endangered Species Act of 1973 Under § 157.206(b)(3)(i) I Appendix I to Subpart F...

  4. 40 CFR 600.206-08 - Calculation and use of FTP-based and HFET-based fuel economy values for vehicle configurations.

    Science.gov (United States)

    2010-07-01

    ... HFET-based fuel economy values for vehicle configurations. 600.206-08 Section 600.206-08 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later Model Year...

  5. 40 CFR 600.206-12 - Calculation and use of FTP-based and HFET-based fuel economy and carbon-related exhaust emission...

    Science.gov (United States)

    2010-07-01

    ... HFET-based fuel economy and carbon-related exhaust emission values for vehicle configurations. 600.206-12 Section 600.206-12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations...

  6. Circulating macrophage activation markers, CD163 and CD206, are associated with disease severity and treatment response in patients with autoimmune hepatitis

    DEFF Research Database (Denmark)

    Grønbæk, Henning; Kazankov, Konstantin; Jessen, Niels;

    Circulating macrophage activation markers, CD163 and CD206, are associated with disease severity and treatment response in patients with autoimmune hepatitis......Circulating macrophage activation markers, CD163 and CD206, are associated with disease severity and treatment response in patients with autoimmune hepatitis...

  7. 30 CFR 206.355 - How do I calculate royalty due on geothermal resources I sell at arm's length to a purchaser for...

    Science.gov (United States)

    2010-07-01

    ... multiplied by the royalty rate in your lease or that BLM prescribes under 43 CFR 3211.18. See § 206.361 for... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I calculate royalty due on geothermal... Geothermal Resources § 206.355 How do I calculate royalty due on geothermal resources I sell at arm's...

  8. Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients

    Directory of Open Access Journals (Sweden)

    Angelini Corrado

    2010-05-01

    Full Text Available Abstract Background MicroRNAs are highly conserved, noncoding RNAs involved in post-transcriptional gene silencing. They have been shown to participate in a wide range of biological processes, including myogenesis and muscle regeneration. The goal of this study is to test the hypothesis that myo-miRs (myo = muscle + miR = miRNA expression is altered in muscle from patients affected by myotonic dystrophy type 1 (DM1, the most frequently inherited neuromuscular disease in adults. In order to gain better insights about the role of miRNAs in the DM1 pathogenesis, we have also analyzed the muscular expression of miR-103 and miR-107, which have been identified in silico as attractive candidates for binding to the DMPK mRNA. Methods To this aim, we have profiled the expression of miR-133 (miR-133a, miR-133b, miR-1, miR-181 (miR-181a, miR-181b, miR-181c and miR-206, that are specifically induced during myogenesis in cardiac and skeletal muscle tissues. miR-103 and miR-107, highly expressed in brain, heart and muscle have also been included in this study. QRT-PCR experiments have been performed on RNA from vastus lateralis biopsies of DM1 patients (n = 7 and control subjects (n = 4. Results of miRNAs expression have been confirmed by Northern blot, whereas in situ hybridization technique have been performed to localize misexpressed miRNAs on muscle sections from DM1 and control individuals. Results Only miR-206 showed an over-expression in 5 of 7 DM1 patients (threshold = 2, fold change between 1.20 and 13.22, average = 5.37 compared to the control group. This result has been further confirmed by Northern blot analysis (3.37-fold overexpression, R2 = 0.89. In situ hybridization localized miR-206 to nuclear site both in normal and DM1 tissues. Cellular distribution in DM1 tissues includes also the nuclear regions of centralized nuclei, with a strong signal corresponding to nuclear clumps. Conclusions This work provides, for the first time, evidences about

  9. miR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Jing, E-mail: zhougjing9888@163.com [Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu (China); Tian, Ye, E-mail: tianye2010077@163.com [Department of Hepatobiliary Surgery, Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui (China); Li, Juan, E-mail: 402310848@163.com [Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu (China); Lu, Binbin, E-mail: lubin1976@163.com [Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu (China); Sun, Ming, E-mail: 422825636@qq.com [Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu (China); Zou, Yanfen, E-mail: 569111165@qq.com [Department of Obstetrics and Gynaecology, Jiangsu Province Hospital, Nanjing, Jiangsu (China); Kong, Rong, E-mail: 31815857@qq.com [Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu (China); Luo, Yanhong, E-mail: 252376737@qq.com [School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu (China); Shi, Yongguo, E-mail: 12071018@qq.com [Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu (China); Wang, Keming, E-mail: Tianyr1@163.com [Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu (China); Ji, Guozhong, E-mail: 252376737@qq.com [Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu (China)

    2013-04-05

    Highlights: ► miR-206 was downexpressed in tumor samples compared with matched normal samples. ► Enhanced expression of miR-206 could inhibit breast cancer growth in vitro. ► Luciferase confirmed miR-206 functions as an anti-oncogene by targeting cyclinD2. ► A reverse correlation between miR-206 and cyclinD2 in breast cancer was found. -- Abstract: MicroRNAs act as important gene regulators in human genomes, and their aberrant expression is linked to many malignancies. Aberrant expression of miR-206 has been frequently reported in cancer studies; however, the role and mechanism of its function in breast cancer remains unclear. Quantitative real-time PCR was performed to detect the relative expression levels of miR-206 in breast cancer and normal breast tissues. Lower expression of miR-206 in breast cancer tissues was associated with larger tumour size and a more advanced clinical stage. Further in vitro observations showed that the enforced expression of miR-206 in MCF-7 breast cancer cells inhibited cell growth by blocking the G1/S transition and suppressed cell proliferation and colony formation, implying that miR-206 functions as a tumour suppressor in the progression of breast cancer. Interestingly, Luciferase assays first revealed that miR-206 inhibited cyclinD2 expression by targeting two binding sites in the 3′-untranslated region of cyclinD2 mRNA. qRT-PCR and Western blot assays verified that miR-206 reduced cyclinD2 expression at both the mRNA and protein levels. A reverse correlation between miR-206 and cyclinD2 expression was noted in breast cancer tissues. Altogether, our results identify a crucial tumour suppressive role of miR-206 in the progression of breast cancer, at least partly via up-regulation of the expression of cyclinD2, and suggest that miR-206 might be a candidate prognostic predictor or an anticancer therapeutic target for breast cancer patients.

  10. MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Lin FO

    2014-09-01

    Full Text Available Feiou Lin,1 Linjie Yao,2 Jin Xiao,3 DengFeng Liu,3 Zhenyu Ni11Department of Orthodontics, 2Department of Pedodontics, 3Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, People’s Republic of ChinaPurpose: MicroRNA-206 (miR-206 has been proven to be downregulated in many human malignancies and is correlated with tumor progression. However, the roles of miR-206 and its related molecular mechanisms in oral squamous cell carcinoma (OSCC are still unclear. Thus, the aim of this study was to explore the effects of miR-206 in OSCC tumorigenesis and development.Methods: Quantitative real-time polymerase chain reaction was used to detect miR-206 expression in OSCC cell lines and primary tumor tissues. The association of miR-206 expression with clinicopathological factors and prognosis was also analyzed. In addition, the effects of miR-206 on the biological behavior of OSCC cells were investigated. Lastly, the potential regulatory function of miR-206 on K-Ras expression was confirmed.Results: MiR-206 expression was significantly downregulated in OSCC tissue samples and cell lines (both P<0.001. Decreased miR-206 expression was significantly associated with advanced tumor node metastasis (TNM stage, advanced T classifications (ie, size and/or extent of the primary tumor, positive N classification (ie, spread to regional lymph nodes, and shorter overall survival. In addition, upregulation of miR-206 in Tca8113 cells was able to reduce cell proliferation, invasion, and migration and promote cell apoptosis in vitro. Further, K-Ras was confirmed as a direct target of miR-206 by using luciferase reporter assay.Conclusion: These findings indicate that miR-206 may act as a tumor suppressor in OSCC and could serve as a novel therapeutic agent for miR-based therapy.Keywords: miR-206, oral squamous cell carcinoma, prognosis, proliferation, apoptosis, invasion

  11. Upgrade of the Cellular General Purpose Monte Carlo Tool FOAM to version 2.06

    CERN Document Server

    Jadach, Stanislaw

    2006-01-01

    FOAM-2.06 is an upgraded version of FOAM, a general purpose, self-adapting Monte Carlo event generator. In comparison with FOAM-2.05, it has two important improvements. New interface to random numbers lets the user to choose from the three "state of the art" random number generators. Improved algorithms for simplical grid need less computer memory; the problem of the prohibitively large memory allocation required for the large number ($>10^6$) of simplical cells is now eliminated -- the new version can handle such cases even on the average desktop computers. In addition, generation of the Monte Carlo events, in case of large number of cells, may be even significantly faster.

  12. [Study on PVA-alginate co-immobilization of Xanthomonas ampelina TS206].

    Science.gov (United States)

    Chen, Qingsen; Liu, Jian

    2003-08-01

    Ice nucleation activity and anti-leaking capability are both important technical parameters in INA (Ice nucleation active bactetia) bacteria immobilization which can be adopted on freezing concentrate. Both PVA and alginate are good medium for immobilization. They can be used on co-immobilization of ice nucleation-active bacteria (Xanthomonas ampelinaTS206). The results showed that quantity of embedding affects ice nucleation activity greatly. The order of importance to comprehensive scores of technical standard should be concentration of Sodium alginate > Boric acid > PVA > CaCl2. The optimized concentration are PVA 8%, sodium alginate 1%, CaCl2 1.1% and boric acid 5%. A conclusion can be draw that ice nucleation activity increases with the number of beads and shows little pertinency with the time of immobilization, whereas anti-leaking capability can be influenced faintly by the number of beads and the time of immobilization. PMID:16276925

  13. Structure of a fluorescent protein from Aequorea victoria bearing the obligate-monomer mutation A206K

    International Nuclear Information System (INIS)

    The first structure of a fluorescent protein derived from A. victoria green fluorescent protein bearing the obligate-monomer mutation A206K is presented and shows no significant structural change in the vicinity of the fluorescent chromophore. The green fluorescent protein (GFP) from the jellyfish Aequoria victoria has been shown to dimerize at high concentrations, which could lead to artefacts in imaging experiments. To ensure a truly monomeric state, an A206K mutation has been introduced into most of its widely used variants, with minimal effect on the spectroscopic properties. Here, the first structure of one of these variants, the cyan fluorescent protein mTurquoise, is presented and compared with that of its dimeric version mTurquoise-K206A. No significant structural change is detected in the chromophore cavity, reinforcing the notion that this mutation is spectroscopically silent and validating that the structural analysis performed on dimeric mutants also applies to monomeric versions. Finally, it is explained why cyan versions of GFP containing the Y66W and N146I mutations do not require the A206K mutation to prevent dimerization at high concentrations

  14. 30 CFR 206.112 - What adjustments and transportation allowances apply when I value oil production from my lease...

    Science.gov (United States)

    2010-07-01

    ... apply when I value oil production from my lease using NYMEX prices or ANS spot prices? 206.112 Section... I value oil production from my lease using NYMEX prices or ANS spot prices? This section applies.... Assume the lessee refines the oil received in exchange at Midland. Assume that the NYMEX price is...

  15. 24 CFR 206.131 - Contract rights and obligations for mortgages on individual dwelling units in a condominium.

    Science.gov (United States)

    2010-04-01

    ... FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND... MORTGAGE INSURANCE Contract Rights and Obligations Condominiums § 206.131 Contract rights and obligations... facilities as may be designated. (c) Assignment of the mortgage. If the mortgagee assigns the mortgage on...

  16. 44 CFR 206.209 - Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major...

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Arbitration for Public... ASSISTANCE Public Assistance Project Administration § 206.209 Arbitration for Public Assistance... 2009, Public Law 111-5, this section establishes procedures for arbitration to resolve disputed...

  17. Patenting human embryonic stem cells in peril: the decision of the Enlarged Board of Appeal in G 2/06

    NARCIS (Netherlands)

    S.J.R. Bostyn

    2009-01-01

    The Enlarged Board of Appeal has recently decided one of the most sensitive cases it has ever had on its hands, but probably not the last. The referral in the G 2/06 case related to the patentability of human embryonic stem cells (hESC). The main question was whether inventions pertaining to the hES

  18. Non-host disease resistance response in pea (Pisum sativum) pods: Biochemical function of DRR206 and phytoalexin pathway localization.

    Science.gov (United States)

    Seneviratne, Herana Kamal; Dalisay, Doralyn S; Kim, Kye-Won; Moinuddin, Syed G A; Yang, Hong; Hartshorn, Christopher M; Davin, Laurence B; Lewis, Norman G

    2015-05-01

    Continually exposed to potential pathogens, vascular plants have evolved intricate defense mechanisms to recognize encroaching threats and defend themselves. They do so by inducing a set of defense responses that can help defeat and/or limit effects of invading pathogens, of which the non-host disease resistance response is the most common. In this regard, pea (Pisum sativum) pod tissue, when exposed to Fusarium solani f. sp. phaseoli spores, undergoes an inducible transcriptional activation of pathogenesis-related genes, and also produces (+)-pisatin, its major phytoalexin. One of the inducible pathogenesis-related genes is Disease Resistance Response-206 (DRR206), whose role in vivo was unknown. DRR206 is, however, related to the dirigent protein (DP) family. In this study, its biochemical function was investigated in planta, with the metabolite associated with its gene induction being pinoresinol monoglucoside. Interestingly, both pinoresinol monoglucoside and (+)-pisatin were co-localized in pea pod endocarp epidermal cells, as demonstrated using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging. In addition, endocarp epidermal cells are also the site for both chalcone synthase and DRR206 gene expression. Taken together, these data indicate that both (+)-pisatin and pinoresinol monoglucoside function in the overall phytoalexin responses.

  19. 75 FR 47588 - Trans Bay Cable, LLC; Notice of Institution of Section 206 Investigation and Refund Effective Date

    Science.gov (United States)

    2010-08-06

    ... Energy Regulatory Commission Trans Bay Cable, LLC; Notice of Institution of Section 206 Investigation and..., concerning the justness and reasonableness of rates proposed by Trans Bay Cable, LLC (Trans Bay) in ] Docket No. ER10-116-000. Trans Bay Cable, LLC, 132 FERC 61,083 (2010). The refund effective date in...

  20. Regulation of nucleolin expression by miR-194, miR-206, and HuR.

    Science.gov (United States)

    Bose, Sudeep; Tholanikunnel, Tracy E; Reuben, Adrian; Tholanikunnel, Baby G; Spicer, Eleanor K

    2016-06-01

    Nucleolin is a proliferation-associated protein that is overexpressed in multiple types of cancer. The mechanisms leading to overexpression of nucleolin in specific cancers are not fully understood. This study found that nucleolin is notably elevated in breast cancer cell lines MCF-7 and MDA-231 compared to nonmalignant breast epithelial MCF-10A cells. In silico analyses revealed the presence of putative binding sites for microRNAs miR-194 and miR-206 in the 3'-untranslated region (3'-UTR) of Ncl mRNA. Transfection of the three cell lines with pre-miR-194 or pre-miR-206 specifically decreased the Ncl mRNA and protein expression. Treatments of the cells with antagomiR-194 or antagomiR-206 upregulated nucleolin expression ~2- to 3-fold. Co-transfection of cells with a reporter vector containing the Ncl 3'-UTR downstream from the Renilla luciferase gene and pre-miR-194 or pre-miR-206 led to a ~3-fold decrease in Renilla/firefly luciferase activity. Cytoplasmic levels of the RNA-binding protein HuR were higher in MCF-7 and MDA-231 cells than those in MCF-10A cells. RNA immunoprecipitation assays demonstrated that HuR binds to Ncl mRNA in all the three cell types. ShRNA-mediated knock-down of HuR induced a decrease in nucleolin expression, while exogenous expression of HuR led to upregulation of nucleolin expression. Analysis of the polysome-monosome distribution of Ncl mRNA in HuR knock-down cells demonstrated that HuR enhances the translation efficiency of Ncl mRNA. These findings demonstrate that nucleolin expression is down-regulated by miR-194 and miR-206 and upregulated by HuR. PMID:27221739

  1. 微小RNA-206对apoE-/-动脉粥样硬化小鼠肝脏X受体α表达的影响%Effect of miRNA-206 on expression of liver X receptor αin apoE-/-mice with atherosclerosis

    Institute of Scientific and Technical Information of China (English)

    刘倩; 梁斌; 边云飞; 王家璞; 肖传实

    2015-01-01

    Objective To investigate the effect of miR-206 on the expression of liver X receptor α (LXRα) in apoE-/-mice with atherosclerosis. Methods Thirty apoE-/-mice aged 4 weeks old were included in the study, and fed with Western diet. All mice were randomly divided into the control group, miR-206 mimic group and miR-206 in-hibitor group after 14 weeks (n=10 each). Blood samples at caudal veins were collected to measure the levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). The severity of aortic atherosclerosis was determined by red oil O staining. Levels of LXRαmRNA and pro-tein were determined by RT-PCR and Western blot, respectively. Results The HDL-C level increased in miR-206 mimic group compared with that in control group. Compared with the control group and miR-206 mimic group, signifi-cantly increased TC and LDL-C levels and decreased HDL-C level were found in miR-206 inhibitor group. There was no significant difference in TG among different groups. Red O staining showed mild aortic atherosclerosis in control group, most severe disease in the miR-206 inhibitor group, and very modest lesion of aortic atherosclerosis in the miR-206 mimic group, respectively. The LXRαexpression increased in miR-206 mimic group and decreased in miR-206 inhibitor group. Conclusion miR-206 may interact with LXRα in forming a feedback loop to regulate the reverse cholesterol transport.%目的:探讨微小RNA(miR)-206对apoE-/-动脉粥样硬化小鼠肝脏X受体α(LXRα)表达的影响。方法取4周龄apoE-/-小鼠30只,喂以高脂饮食,14周后随机分成对照组、miR-206 mimic组、miR-206 in-hibitor组,每组10只。尾静脉采血检测总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),油红O染色观察主动脉粥样硬化程度,荧光定量聚合酶链反应(RT-PCR)测

  2. Impact assessment of 206 000 t bulk carrier based on harmonised common structural rules%协调版共同结构规范对20.6万吨散货船的影响评估

    Institute of Scientific and Technical Information of China (English)

    陈倩; 邱吉廷; 吴嘉蒙; 张帆

    2015-01-01

    20.6万吨散货船为例,通过描述性规定与直接强度计算,对比分析协调版共同规范与油船共同规范的差异,评估新规范对目前散货船结构可能带来的影响。%The differences between common structural rules for bulk carriers (CSR-BC) and harmonised common structural rules (CSR-H) are analyzed according to the prescriptive regulation and direct strength calculation of a 206 000 t bulk carrier. The possible impact of the new rules on the structural design of bulk carriers is then assessed.

  3. The Hardware Design of Power Quality Analysis Board Based on TMS320F206%基于TMS320F206的电网数据处理板设计

    Institute of Scientific and Technical Information of China (English)

    王金亮; 程丽萍

    2004-01-01

    介绍了基于DSP芯片TMS320F206的电网采样处理板的软、硬件设计方法,对硬件各模块电路的工作原理作了重点的讨论,同时给出了该电网数据处理板的主程序和中断处理程序流程图.

  4. Proteome Analysis of Disease Resistance against Ralstonia solanacearum in Potato Cultivar CT206-10.

    Science.gov (United States)

    Park, Sangryeol; Gupta, Ravi; Krishna, R; Kim, Sun Tae; Lee, Dong Yeol; Hwang, Duk-Ju; Bae, Shin-Chul; Ahn, Il-Pyung

    2016-02-01

    Potato is one of the most important crops worldwide. Its commercial cultivars are highly susceptible to many fungal and bacterial diseases. Among these, bacterial wilt caused by Ralstonia solanacearum causes significant yield loss. In the present study, integrated proteomics and genomics approaches were used in order to identify bacterial wilt resistant genes from Rs resistance potato cultivar CT-206-10. 2-DE and MALDI-TOF/TOF-MS analysis identified eight differentially abundant proteins including glycine-rich RNA binding protein (GRP), tomato stress induced-1 (TSI-1) protein, pathogenesis-related (STH-2) protein and pentatricopeptide repeat containing (PPR) protein in response to Rs infection. Further, semi-quantitative RT-PCR identified up-regulation in transcript levels of all these genes upon Rs infection. Taken together, our results showed the involvement of the identified proteins in the Rs stress tolerance in potato. In the future, it would be interesting to raise the transgenic plants to further validate their involvement in resistance against Rs in potato. PMID:26889112

  5. Proteome Analysis of Disease Resistance against Ralstonia solanacearum in Potato Cultivar CT206-10

    Directory of Open Access Journals (Sweden)

    Sangryeol Park

    2016-02-01

    Full Text Available Potato is one of the most important crops worldwide. Its commercial cultivars are highly susceptible to many fungal and bacterial diseases. Among these, bacterial wilt caused by Ralstonia solanacearum causes significant yield loss. In the present study, integrated proteomics and genomics approaches were used in order to identify bacterial wilt resistant genes from Rs resistance potato cultivar CT-206-10. 2-DE and MALDI-TOF/TOF-MS analysis identified eight differentially abundant proteins including glycine-rich RNA binding protein (GRP, tomato stress induced-1 (TSI-1 protein, pathogenesis-related (STH-2 protein and pentatricopeptide repeat containing (PPR protein in response to Rs infection. Further, semi-quantitative RT-PCR identified up-regulation in transcript levels of all these genes upon Rs infection. Taken together, our results showed the involvement of the identified proteins in the Rs stress tolerance in potato. In the future, it would be interesting to raise the transgenic plants to further validate their involvement in resistance against Rs in potato.

  6. Serum Levels of MicroRNA-206 and Novel Mini-STR Assays for Carrier Detection in Duchenne Muscular Dystrophy

    Science.gov (United States)

    Anaya-Segura, Mónica Alejandra; Rangel-Villalobos, Héctor; Martínez-Cortés, Gabriela; Gómez-Díaz, Benjamín; Coral-Vázquez, Ramón Mauricio; Zamora-González, Edgar Oswaldo; García, Silvia; López-Hernández, Luz Berenice

    2016-01-01

    Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disorder in which the detection of female carriers is of the utmost importance for genetic counseling. Haplotyping with polymorphic markers and quantitation of creatine kinase levels (CK) allow tracking of the at-risk haplotype and evidence muscle damage, respectively. Such approaches are useful for carrier detection in cases of unknown mutations. The lack of informative markers and the inaccuracy of CK affect carrier detection. Therefore, herein we designed novel mini-STR (Short Tandem Repeats) assays to amplify 10 loci within the DMD gene and estimated allele frequencies and the polymorphism information content among other parameters in 337 unrelated individuals from three Mexican populations. In addition, we tested the utility of the assays for carrier detection in three families. Moreover, given that serum levels of miR-206 discern between DMD patients and controls with a high area under the curve (AUC), the potential applicability for carrier detection was assessed. The serum levels of miR-206 of non-carriers (n = 24) and carriers (n = 23) were compared by relative quantitation using real-time PCR (p < 0.05), which resulted in an AUC = 0.80 in the Receiver Operating Characteristic curve analysis. In conclusion, miR-206 has potential as a “liquid biopsy” for carrier detection and genetic counseling in DMD. PMID:27529242

  7. Serum Levels of MicroRNA-206 and Novel Mini-STR Assays for Carrier Detection in Duchenne Muscular Dystrophy

    Directory of Open Access Journals (Sweden)

    Mónica Alejandra Anaya-Segura

    2016-08-01

    Full Text Available Duchenne Muscular Dystrophy (DMD is an X-linked neuromuscular disorder in which the detection of female carriers is of the utmost importance for genetic counseling. Haplotyping with polymorphic markers and quantitation of creatine kinase levels (CK allow tracking of the at-risk haplotype and evidence muscle damage, respectively. Such approaches are useful for carrier detection in cases of unknown mutations. The lack of informative markers and the inaccuracy of CK affect carrier detection. Therefore, herein we designed novel mini-STR (Short Tandem Repeats assays to amplify 10 loci within the DMD gene and estimated allele frequencies and the polymorphism information content among other parameters in 337 unrelated individuals from three Mexican populations. In addition, we tested the utility of the assays for carrier detection in three families. Moreover, given that serum levels of miR-206 discern between DMD patients and controls with a high area under the curve (AUC, the potential applicability for carrier detection was assessed. The serum levels of miR-206 of non-carriers (n = 24 and carriers (n = 23 were compared by relative quantitation using real-time PCR (p < 0.05, which resulted in an AUC = 0.80 in the Receiver Operating Characteristic curve analysis. In conclusion, miR-206 has potential as a “liquid biopsy” for carrier detection and genetic counseling in DMD.

  8. Serum Levels of MicroRNA-206 and Novel Mini-STR Assays for Carrier Detection in Duchenne Muscular Dystrophy.

    Science.gov (United States)

    Anaya-Segura, Mónica Alejandra; Rangel-Villalobos, Héctor; Martínez-Cortés, Gabriela; Gómez-Díaz, Benjamín; Coral-Vázquez, Ramón Mauricio; Zamora-González, Edgar Oswaldo; García, Silvia; López-Hernández, Luz Berenice

    2016-01-01

    Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disorder in which the detection of female carriers is of the utmost importance for genetic counseling. Haplotyping with polymorphic markers and quantitation of creatine kinase levels (CK) allow tracking of the at-risk haplotype and evidence muscle damage, respectively. Such approaches are useful for carrier detection in cases of unknown mutations. The lack of informative markers and the inaccuracy of CK affect carrier detection. Therefore, herein we designed novel mini-STR (Short Tandem Repeats) assays to amplify 10 loci within the DMD gene and estimated allele frequencies and the polymorphism information content among other parameters in 337 unrelated individuals from three Mexican populations. In addition, we tested the utility of the assays for carrier detection in three families. Moreover, given that serum levels of miR-206 discern between DMD patients and controls with a high area under the curve (AUC), the potential applicability for carrier detection was assessed. The serum levels of miR-206 of non-carriers (n = 24) and carriers (n = 23) were compared by relative quantitation using real-time PCR (p < 0.05), which resulted in an AUC = 0.80 in the Receiver Operating Characteristic curve analysis. In conclusion, miR-206 has potential as a "liquid biopsy" for carrier detection and genetic counseling in DMD. PMID:27529242

  9. Elastic and inelastic scattering of polarized protons from lead-206 and lead-208 near isobaric analog resonances

    International Nuclear Information System (INIS)

    Excitation functions have been measured for elastic scattering of polarized protons from 206Pb and 208Pb, and for inelastic scattering to collective states in 206Pb (2+, 0.8033 MeV; 3-, 2.647 MeV) and 208Pb (3-, 2.6145 MeV). Both differential cross sections and analyzing powers were measured at theta/sub lab/ = 1200, 1350, 1500, and 1650, for E/sub p/ = 14.25 to 18 MeV. Fits to the excitation-function data were obtained using scattering amplitudes consisting of sums of resonant and non-resonant parts. The resonances are the isobaric analogs (IARs) of 7 low-lying states in 209Pb and 35 in 207Pb. The fits to the elastic-scattering data are excellent; for the inelastic scattering the fit is very good for the 2+ state but only fair for the 3- states. For each IAR, the energy, the total width, and the partial width and mixing phase in each channel were obtained. Also, new spin assignments were made for a number of parent states in 207Pb. The theory of Bund and Blair was used to find the spectroscopic amplitudes, which provide information on the wave functions for the parent states in 207Pb and 209Pb and for the 3- states in 206Pb and 208Pb. These spectroscopic amplitudes were then checked for internal consistency and compared with the results of other experiments and with theoretical predictions

  10. MicroRNA-206 regulates the secretion of inflammatory cytokines and MMP9 expression by targeting TIMP3 in Mycobacterium tuberculosis-infected THP-1 human macrophages.

    Science.gov (United States)

    Fu, Xiangdong; Zeng, Lihong; Liu, Zhi; Ke, Xue; Lei, Lin; Li, Guobao

    2016-08-19

    Tuberculosis (TB) is a serious disease that is characterized by Mycobacterium tuberculosis (M.tb)-triggered immune system impairment and lung tissue damage shows limited treatment options. MicroRNAs (miRNAs) are regulators of gene expression that play critical roles in many human diseases, and can be up- or downregulated by M.tb infection in macrophage. Recently, tissue inhibitor of matrix metalloproteinase (TIMP) 3 has been found to play roles in regulating macrophage inflammation. Here, we found that TIMP3 expression was regulated by miR-206 in M.tb-infected THP-1 human macrophages. In THP-1 cells infected with M.tb, the miR-206 level was significantly upregulated and the expression of TIMP3 was markedly decreased when the secretion of inflammatory cytokines was increased. Inhibition of miR-206 markedly suppressed inflammatory cytokine secretion and upregulated the expression of TIMP3. In contrast, the upregulation of miR-206 promoted the matrix metalloproteinase (MMP) 9 levels and inhibited TIMP3 levels. Using a dual-luciferase reporter assay, a direct interaction between miR-206 and the 3'-untranslated region (UTR) of TIMP3 was confirmed. SiTIMP3, the small interfering RNA (siRNA) specific for TIMP3, significantly attenuated the suppressive effects of miR-206-inhibitor on inflammatory cytokine secretion and MMP9 expression. Our data suggest that miR-206 may function as an inflammatory regulator and drive the expression of MMP9 in M.tb-infected THP-1 cells by targeting TIMP3, indicating that miR-206 is a potential therapeutic target for patients with TB. PMID:27291149

  11. 氯胺酮对抑郁大鼠海马微小RNA206表达的影响%Effect of ketamine on expression of hippocampal microRNA-206 in mentally depressed rats

    Institute of Scientific and Technical Information of China (English)

    杨晓玲; 周敏; 王晓斌; 王姬; 万运强; 张春祥

    2016-01-01

    目的 评价氯胺酮对抑郁大鼠海马微小RNA 206(miR-206)表达的影响.方法 清洁级健康雌性SD大鼠80只,体重200~300 g,2~3月龄,采用随机数字表法,将其分为4组(n=20):正常对照组(C组)、氯胺酮组(K组)、抑郁组(D组)和抑郁+氯胺酮组(D+K组).采用慢性不可预见轻度应激法制备大鼠抑郁模型.于模型制备成功后1d时,K组和D+K组腹腔注射氯胺酮15 mg/kg,其它2组给予等容量生理盐水.每组取10只大鼠,于模型制备前、模型制备7、14、21、28、35 d、给药后1、3、5和7d时行糖水偏好实验,于给药后1d时行旷场实验,于给药后2d时行强迫游泳实验.每组于给药后6h时取5只大鼠,采用实时定量PCR法检测海马miR-206表达;每组于给药后2d时取5只大鼠,采用Western blot法检测海马脑源性神经营养因子(BDNF)表达.结果 与C组比较,D组模型制备21~35 d、给药后各时点蔗糖摄入量和旷场实验评分降低,强迫游泳不动时间缩短,海马miR-206表达上调,海马BDNF表达下调,K组强迫游泳不动时间缩短,海马miR-206表达下调,海马BDNF表达上调,D+K组模型制备21~35 d时蔗糖摄入量和旷场实验评分降低(P<0.05);与D组比较,D+K组给药后各时点蔗糖摄入量升高,强迫游泳不动时间缩短,海马miR-206表达下调,海马BDNF表达上调(P<0.05).结论 氯胺酮对大鼠发挥抗抑郁作用的机制与下调海马miR-206表达,上调海马BDNF表达有关.%Objective To evaluate the effect of ketamine on the expression of hippocampal microRNA-206 (miR-206) in the mentally depressed rats.Methods Eighty healthy female Sprague-Dawley rats,weighing 200-300 g,aged 2-3 months,were randomly divided into 4 groups (n=20 each) using a random number table:normal control group (C group),ketamine group (K group),depression group (D group) and depression + ketamine group (D+K group).Mental depression was induced by exposing the animal to chronic unpredictable mild stress.At 1

  12. The role of Ethics in the process of Technology Transfer and Development of 206 Peugeot

    Directory of Open Access Journals (Sweden)

    Aliakbar Mazlomi

    2011-02-01

    Full Text Available Looking at the past history we find that the first phenomenon of technology transfer was taught by people who were traveling to another community and bring their technology, they move. After theindustrialization, transfer of knowledge from individuals to maintain their importance. However, now the situation for developing countries is controversial because it denied people with technical skills fromdeveloped countries to developing countries do not migrate, but the reverse is the professionals that are developing countries to developed countries loan go. Until developing countries can train your human resources specialist, they powerful companies overseas are the means of technology transfer, whether through direct investment, and whether through the sale of licenses and other means. (Noble, p. 105 - 106, 1367 Technology transfer is an important issue that should be given the capacity of countries to assess the possibility of application, absorption and its compatibility with local conditions to increase. Ie the transfer of technology and gain access to technology for its effective use for economic development and growth of countries relatively backward technology provides. (Archibugi, 2003 Today, the role of ethics in technology transfer and development is of great importance. The meaning of ethics and technology than are harvested, ethical values that have roles in the formation of modern technology. Another meaning of ethics and technology than is reached, that moral people who are dealing with technology, they must observe. It also includes technology to those that exist and sets it to those who apply and who are the analysis and criticism. In this article factors and ethical factors in the process of technology transfer and development for Peugeot 206 in Iran Khodro Company has been studied. For this purpose a questionnaire to determine and evaluate factors is designed and results are analyzed.

  13. Isolation and identification of 206 strains of candida and analysis of their drug resistance%临床分离206株念珠菌的培养鉴定及其耐药性分析

    Institute of Scientific and Technical Information of China (English)

    王业芳

    2011-01-01

    Objective To isolate and identify 206 strains of candida,and to test their microbial sensitivity in order to guide rational clinical administration. Methods Samples including sputum, urine, blood and other secretion sent for detection from Jan. to Dec. 2010, were cultured and isolated by routine methods, and identified with France Biomerieux ATB express system. A drug sensitivity test was done by ATB fungus strip. Results Among the 206 strains of candida,Candida albicans was the most frequently species(41.75%),followed by C. tropicalis(24.76%),C, parapsilosis(14.08%),C, krusei(9.71%),C, glabrata(7.28%) and others (2.43%). All the 206 strains of candida were sensitive to amphotericin B and did not express resistance, most of them were sensirive to 5 fluorocytosine and nystatinum,and the resistance rates were lower. The resistance rates of most of them to ketoconnazole,econazole,miconazole were higher and cross resistance appeared. Conclusion Fungi are required to be sent for classification and drug resistance study so as to rationally use anti fungal agent to reduce the development of drug resistant strains.%目的 对引起感染的206株临床分离的念珠菌进行分离鉴定和药敏试验,了解念珠菌耐药现状,以指导临床合理用药.方法 收集2010年1~12月临床送检的痰液、尿液、血液及各种分泌物等标本,采用常规方法培养和分离念珠菌,用法国生物梅里埃ATB express系统对念珠菌进行鉴定,用ATB fungus药敏试条进行药敏试验.结果 206株念珠菌中,白色念珠菌占41.75%、热带念珠菌占24.76%、近平滑念珠菌占14.08%、克柔念珠菌占9.71%、光滑念珠菌占7.28%、其他念珠菌占2.43%.206株念珠菌对两性霉素B敏感,未出现抗药性;绝大多数菌株对5-氟胞嘧啶、制霉菌素敏感,耐药率较低;对3种咪唑类药物(酮康唑、益康唑、咪康唑)耐药率较高且出现交叉耐药.结论 临床需要加强真菌送检培养,合理使用

  14. 抗TY番茄新品种星宇206的选育%Breeding of Xingyu 206, a New Tomato Cultivar Highly Resistant to Tomato Yellow Leaf Curl Virus Disease

    Institute of Scientific and Technical Information of China (English)

    尚春明; 张东旭; 贺荣; 王伟; 程玉琳; 姚慧静

    2015-01-01

    Xingyu 206 is a middle-maturing tomato F1 hybrid developed by crossing S5 as female parent and TS19 as male parent. It has strong growth vigor and high fruit-setting rate. Its fruit is pink, round, and tastes well, with its average single fruit weight is about 230 g. Xingyu 206 is highly resistant to tomato yellow leaf curl virus disease (TY), and it is also tolerant to fusarium wilt, leaf mold and root-knot nematode disease. Additionally, it is heat-resisting, and tolerant to fruit cracking and storage and transportation, so it can be planted in early-spring or early-autumn greenhouse in both southern and northern China.%星宇206是以S5为母本、以TS19为父本配制成的中熟番茄杂交一代品种。生长旺盛,坐果率高,丰产性好,果实粉红色、正圆形,平均单果质量230 g左右;色泽鲜艳,口味佳,抗裂果,耐储运;高抗番茄黄化曲叶病毒病(TY),兼抗烟草花叶病毒病、枯萎病、叶霉病、根结线虫病;耐热性强,适宜于南北方早秋、早春日光温室和大棚越夏栽培。

  15. Mixed Signal Generation System Based on C8051F206 and FT245R USB%基于C8051F206和FT245R USB的混合信号生成系统

    Institute of Scientific and Technical Information of China (English)

    虞文胜; 温倩

    2014-01-01

    In order to generate self-check signal and speed instruction of radar antenna system test signals, design a kind of mixed signal generation system based on C8051F206 and FT245R.The system uses FT245R USB chip to realize the communication of upper machine, and rely on C8051F206 high SPC and C language to response the instructions of upper machine in a reliable way and send real-time measured parts required for the self-check instruction ,speed instruction,etc.This paper introduces the principle of hardware design and software design of mixed signal systems. Practical application shows that the system can accurately generate radar antenna system self-check signal, speed signal and real-time feedback test results.%为了产生雷达天线系统测试时所需的自检信号、速度指令等信号,设计了一种基于基于 C8051F206和FT245R的混合信号生成系统。该系统利用FT245R USB接口芯片实现与上位机通信,并依靠C8051F206高程控性和C语言的高灵活性,可靠地响应上位机指令并实时发送被测件所需的自检信号、速度指令等信号源。介绍了混合信号生成系统硬件设计和软件设计的原理。实际应用表明,该系统能准确地生成被测件雷达天线系统所需的自检信号、速度指令信号,并实时地反馈测试结果。

  16. 烧伤后期并发应激性溃疡206例临床分析%Clinical analysis of 206 late-stage burned patients complicated with stress ulcer

    Institute of Scientific and Technical Information of China (English)

    李梅

    2013-01-01

    Objective To explore the clinical features,treatment methods and effects of late-stage burned complicated with stress ulcer.Methods The clinical data of 206 burned patients were retrospectively analyzed,and the clinical features,treatment methods and effects of burned patients complicated with stress ulcer were analyzed.Results In 206 patients,there were 42 late-stage burned patients complicated with stress ulcer(20.4%),of which 34 cases were cured(81.0%),8 cases died(19.0%) (3 cases died of stress ulcer bleeding,5 cases died of stress ulcer bleeding complications).Conclusion The probability of late-stage burned complicated with stress ulcer is high and dangerous.For the patients with late-stage burned patients complicated with stress ulcer,early enteral nutrition,gastric mucosal protection,wound sepsis to prevent wound infection,the treatment measures should be effectively put into practice,which will be good for making patients stable,and then the patients can be cured.%目的 探讨烧伤后期并发应激性溃疡临床的临床特点、治疗方法及效果.方法 回顾性分析206例烧伤患者的临床资料,分析后期并发应激性溃疡患者的临床特点、治疗方法及效果.结果 该组206例患者,后期并发应激性溃疡患者42例(20.4%),其中治愈34例(81.0%),死亡8例(19.0%)(其中3例患者死于应激性溃疡大出血,5例患者死于应激性溃疡出血后其它并发症).结论 烧伤后期并发应激性溃疡的概率较高,危险性大.对于烧伤后期并发应激性溃疡患者的治疗,通过早期肠道营养、胃黏膜保护、创面脓毒血症的防止、创面感染的处理等措施的有效实施,可较好的稳定患者度过休克期,进而得以治愈.

  17. The novel biomarker of alternative macrophage activation, soluble mannose receptor (sMR/sCD206): Implications in multiple myeloma

    DEFF Research Database (Denmark)

    Andersen, Morten N; Andersen, Niels F; Rødgaard-Hansen, Sidsel;

    2015-01-01

    Tumor-associated macrophages (TAMs) play an important role in the pathophysiology of human malignancies. They support growth of cancer cells by promoting angiogenesis, and by inhibiting tumour cell apoptosis and anti-tumor immune reactions. Several membrane proteins are well-described markers...... of human TAMs, including the haemoglobin scavenger receptor CD163 and the macrophage mannose receptor (MR/CD206). Interestingly, both CD163 and MR exist as soluble serum proteins (sCD163 and sMR) that may reflect the activation state of tissue macrophages, including TAMs. Here, we report the first data...

  18. 特比奈芬凝胶治疗206例浅部真菌病患者的疗效观察%Clinical Observation of Terbinafine Gel Treatment of 206 Cases with Superficial Mycoses

    Institute of Scientific and Technical Information of China (English)

    孙成军

    2012-01-01

      Objective Hydrochloride terbinafine gel treatment of superficial mycoses. Methods 206 cases of superficial mycoses in patients with topical terbinafine gel treatment, 2 times a day, three weeks after effects were observed. Results Terbinafine tinea corporis on the body of gel in the treatment of piebald pityriasis and tinea and other superficial fungal infection of the total efficiency of 97.8%, respectively, 94%, 90.9%. Conclusion Terbinafine gel topical treatment of superficial fungal disease curative effect.%  目的 观察盐酸特比奈芬凝胶对浅部真菌病的治疗效果.方法 选择206例浅部真菌病患者,外用特比奈芬凝胶治疗,每日2次,3周后观察疗效.结果 特比奈芬凝胶治疗体股癣、花斑糠疹及手足癣等浅部真菌感染的总有效率分别为97.8%、94%、90.9%.结论 特比奈芬凝胶外用治疗浅部真菌病的疗效确切.

  19. Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review).

    Science.gov (United States)

    Xie, Meng; Dart, Dafydd Alwyn; Owen, Sioned; Wen, Xianzi; Ji, Jiafu; Jiang, Wenguo

    2016-09-01

    Gastric cancer (GC) remains the third most common cause of cancer deaths worldwide and carries a high rate of metastatic risk contributing to the main cause of treatment failure. An accumulation of data has resulted in a better understanding of the molecular network of GC, however, gaps still exist between the unique bio-resources and clinical application. MicroRNAs are an important part of non-coding RNAs and behave as major regulators of tumour biology, alongside their well-known roles as intrinsic factors of gene expression in cellular processes, via their post-transcriptional regulation of components of signalling pathways in a coordinated manner. Deregulation of the miR-1, -133 and -206 family plays a key role in tumorigenesis, progression, invasion and metastasis. This review aims to provide a summary of recent findings on the miR-1, -133 and -206 family in GC and how this knowledge might be exploited for the development of future miRNA-based therapies for the treatment of GC. PMID:27349337

  20. One atmosphere viscosity measurements of MORBs from ODP Leg 206, Hole 1256D

    Science.gov (United States)

    Sato, H.; Nakamura, H.; Ishibashi, H.

    2009-12-01

    We carried out viscosity measurements of MORBs from ODP Leg 206, Hole 1256D at one atmosphere both in hyperliquidus and subliquidus conditions. Three samples examined are #1 (core 39R1), #2(core 27R19) and #3 (core 3R4). They are typical MORBs but have different Mg/(Mg+Fe) ratios of 0.60, 0.48, and 0.42. Viscosity measurements were carried out mostly after the method of Sato (2005, J. Mineral. Petrol. Sci),. The oxygen fugacity of the furnace was controlled by mixed gas of CO2:H2(400/20ml/min), at FMQ buffer conditions. Rotational viscometer was connected to a ceramic rod of 6 mm diameter, the end of which immersed in the sample crucible 30 mm inner diameter and 60 mm high. The system is calibrated with standard viscosity oils for different depths. The samples were initially melted at ca. 50 C higher temperature than liquidus, and kept for 3 days before viscometry and sampling. After the viscometry and sampling, the furnace temperature was decreased by 5 to 30 C, and kept for 1-3 days before another viscometry and sampling. These steps are repeated until the high viscosity of the melt precluded the measurements. The quenched samples were analayzed for phase chemistry and textural features. Sample #1 crystallized plagioclase and olivine at 1215 C, followed by augite at 1205 C. Total crystal content increased to 29 vol% at 1185 C. Sample #2 crystallized plagioclase and pigeonite at 1175 C, followed by olivine and augite at 1165 C. Total crystal content increased up to 25 vol% at 1152 C. Sample #3 crystallized plagioclase, pigeonite and olivine at 1155 C. Total crystal content increased up to 25 vol% at 1133 C. Bulk viscosity increased from 46 to 74 Pa s at hyperliquidus temperatures of 1240 to 1210 C, whereas it increased up to 2908 Pa s in subliquidus temperatures of 1185 C in the sample #1. In the sample #2, bulk viscosity also increased slowly from 42 Pa s at 1232 C to 79 Pa s at 1172 C, then increased much rapidly to 3422 Pa s at 1152 C. Similarly, the sample #3

  1. 海藻酸钙固定化对Xanthomonas campestris 206冰核活性的影响%Effect of Calcium Alginate Immobilization on Ice Nucleation Activity of Xanthomonas campestris 206

    Institute of Scientific and Technical Information of China (English)

    刘健; 陈庆森

    2002-01-01

    应用正交法研究了海藻酸钙固定化对Xanthomonas campestris 206冰核活性的影响.结果表明,对固定化小球冰核活性影响程度大小的顺序依次为:菌悬液用量>海藻酸钠用量>CaCl2浓度>固化时间,而对渗漏量影响程度大小的顺序依次为:菌悬液用量>固化时间>CaCl2浓度>海藻酸钠用量.研究中还发现,将冰核活性细菌固定化在热稳定性方面实际意义不大.

  2. Effects of miR-206/miR-1 on Breast Cancer Stem Cell Proliferation and the Mechanism%miR-206/miR-1对乳腺癌干细胞增殖的影响及作用机制

    Institute of Scientific and Technical Information of China (English)

    孟琳; 王天一; 李晓曦; 马萍

    2015-01-01

    Objective To investigate the effects of up⁃regulated miR⁃206/miR⁃1 on the proliferation of breast cancer stem cells and the effect mech⁃anism. Methods Breast cancer stem cells(BCSCs)were isolated from breast cancer cell line MCF⁃7 by fluorescence⁃activated cell sorting. Cells in the experiment were divided into the blank control group,the negative control group,the miR⁃206 group and the miR⁃1 group. The BCSCs were transfected by negative control mimic,hsa⁃miR⁃206mimic and hsa⁃miR⁃1mimic in all groups except the blank control group. MiR⁃206and miR⁃1 expression levels as well as the transcription factor EVI⁃1 gene were detected by real time PCR. The expression levels of the transcription factor EVI⁃1 protein were detected by Western blot. MTT method was used to detect the effects of miR⁃206 and miR⁃1 on the proliferation of BCSCs. Results The BCSCs(CD44+/CD24-/low cells)isolated from MCF⁃7 cell lines were successfully cultured in serum⁃free medium for subsequent studies. After transfection of hsa⁃miR⁃206mimic and hsa⁃miR⁃1mimic for 48 hours,miR⁃206and miR⁃1relative expression levels increased. EVI⁃1mRNA ex⁃pression levels significantly decreased. The results of Western blot and MTT showed that up⁃regulated expression levels of miR⁃206 and miR⁃1 could significantly reduce the expression of EVI⁃1 protein and inhibited the proliferation of BCSCs. The differences in levels of miR⁃206,miR⁃1 and EVI⁃1 protein were statistically significant(P<0.05). Conclusion Up⁃regulated miR⁃206 and miR⁃1 expression can inhibit the proliferation ability of BCSCs,which may be related to the down⁃regulation of EVI⁃1.%目的:探讨上调microRNA⁃206(miR⁃206)和microRNA⁃1(miR⁃1)表达对乳腺癌干细胞增殖的影响以及其作用机制。方法采用流式细胞分选技术从乳腺癌细胞株MCF⁃7中分离出乳腺癌干细胞。实验分为空白对照组、阴性对照组、miR⁃206

  3. miRNA 206 and miRNA 574-5p are highly expression in coronary artery disease

    Science.gov (United States)

    Zhou, Jianqing; Shao, Guofeng; Chen, Xiaoliang; Yang, Xi; Huang, Xiaoyan; Peng, Ping; Ba, Yanna; Zhang, Lin; Jehangir, Tashina; Bu, Shizhong; Liu, Ningsheng; Lian, Jiangfang

    2015-01-01

    Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide. Innovative diagnostic biomarkers are a pressing need for this disease. miRNAs profiling is an innovative method of identifying biomarkers for many diseases and could be proven as a powerful tool in the diagnosis and treatment of CAD. We performed miRNA microarray analysis from the plasma of three CAD patients and three healthy controls. Subsequently, we performed quantitative real-time PCR (qRT-PCR) analysis of miRNA expression in plasma of another 67 CAD patients and 67 healthy controls. We identified two miRNAs (miR-206 and miR-574-5p) that were significantly up-regulated in CAD patients as compared with healthy controls (P<0.05). The receiver operating characteristic (ROC) curves indicated these two miRNAs had great potential to provide sensitive and specific diagnostic value for CAD. PMID:26685009

  4. Roles of the canonical myomiRs mi R-1,-133 and-206 in cell development and disease

    Institute of Scientific and Technical Information of China (English)

    Keith; Richard; Mitchelson; Wen-Yan; Qin

    2015-01-01

    Micro RNAs are small non-coding RNAs that participate in different biological processes, providing subtle combinational regulation of cellular pathways, often by regulating components of signalling pathways. Aberrant expression of mi RNAs is an important factor in the development and progression of disease. The canonical myomi Rs(mi R-1,-133 and-206) are central to the development and health of mammalian skeletal and cardiac muscles, but new findings show they have regulatory roles in the development of other mammalian non-muscle tissues, including nerve, brain structures, adipose and some specialised immunological cells. Moreover, the deregulation of myomi R expression is associated with a variety of different cancers, where typically they have tumor suppressor functions, although examples of an oncogenic role illustrate their diverse function in different cell environments. This review examines the involvement of the related myomi Rs at the crossroads between cell development/tissue regeneration/tissue inflammation responses, and cancer development.

  5. A soluble form of the macrophage-related mannose receptor (MR/CD206) is present in human serum and elevated in critical illness

    DEFF Research Database (Denmark)

    Rødgaard-Hansen, Sidsel; Rafique, Aisha; Christensen, Peter A;

    2014-01-01

    Background: This study tests the hypothesis that the mannose receptor (MR/CD206), which is expressed primarily by macrophages and dendritic cells, can be found in a soluble form (sMR, sMR) in human serum. Furthermore, we wished to establish and validate an enzyme-linked immunosorbent assay (ELISA...

  6. Effect of Mn, Si, and Cooling Rate on the Formation of Iron-Rich Intermetallics in 206 Al-Cu Cast Alloys

    Science.gov (United States)

    Liu, K.; Cao, X.; Chen, X.-G.

    2012-10-01

    The solidification structures of commercial 206 Al-Cu cast alloys with 0.15 pct Fe have been studied using thermal analysis (TA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and electron backscattered diffraction (EBSD). The EBSD results have shown that there are two iron-rich intermetallics: Chinese script α-Fe and platelet-like β-Fe. The addition of either Mn or Si has helped to promote the formation of α-Fe and hinder the precipitate of β-Fe. The combined addition of both Mn and Si is even more effective than the individual addition of either Mn or Si. The full solidification sequence of the 206 cast alloy has been established. The volume percent and formation temperature increase for α-Fe but decrease for β-Fe with increasing cooling rate. The platelet β-Fe can be effectively suppressed in 206 cast alloys by controlling the alloy chemistry and cooling rate. A casting process map is proposed to correlate the Mn and Si contents with cooling rates for the 206 cast alloys.

  7. The He I 2.06 microns/Br-gamma ratio in starburst galaxies - An objective constraint on the upper mass limit to the initial mass function

    Science.gov (United States)

    Doyon, Rene; Puxley, P. J.; Joseph, R. D.

    1992-01-01

    The use of the He I 2.06 microns/Br-gamma ratio as a constraint on the massive stellar population in star-forming galaxies is developed. A theoretical relationship between the He I 2.06 microns/Br-gamma ratio and the effective temperature of the exciting star in H II regions is derived. The effects of collisional excitation and dust within the nebula on the ratio are also considered. It is shown that the He I 2.06 microns/Br-gamma ratio is a steep function of the effective temperature, a property which can be used to determine the upper mass limit of the initial mass function (IMF) in galaxies. This technique is reliable for upper mass limits less than about 40 solar masses. New near-infrared spectra of starburst galaxies are presented. The He I 2.06 microns/Br-gamma ratios observed imply a range of upper mass limits from 27 to over 40 solar masses. There is also evidence that the upper mass limit is spatially dependent within a given galaxy. These results suggest that the upper mass limit is not a uniquely defined parameter of the IMF and probably varies with local physical conditions.

  8. 30 CFR 206.181 - How do I establish processing costs for dual accounting purposes when I do not process the gas?

    Science.gov (United States)

    2010-07-01

    ... Processing Allowances § 206.181 How do I establish processing costs for dual accounting purposes when I do... methods to establish processing costs for dual accounting purposes: (a) The average of the costs... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I establish processing costs for...

  9. Arvustus : Vello Paatsi. Eesti talurahva loodusteadusliku maailmapildi kujunemine rahvakooli kaudu (1803-1918). - Tallinn : TPÜ Kirjastus, 2003. 206 lk. / Jaan-Mati Punning

    Index Scriptorium Estoniae

    Punning, Jaan-Mati

    2003-01-01

    Rets. rmt. : Paatsi, Vello. Eesti talurahva loodusteadusliku maailmapildi kujunemine rahvakooli kaudu (1803-1918). - Tallinn : Tallinna Pedagoogikaülikooli kirjastus, 2003. - 206 lk. : ill. - (Tallinna Pedagoogikaülikool. Sotsiaalteaduste dissertatsioonid = Tallinn Pedagogical University. Dissertations on social sciences, 1406-4405 ; 5)

  10. 12 CFR 347.206 - Domestic retail deposit activity requiring deposit insurance by U.S. branch of a foreign bank.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Domestic retail deposit activity requiring... Banks § 347.206 Domestic retail deposit activity requiring deposit insurance by U.S. branch of a foreign bank. (a) Domestic retail deposit activity. To initiate or conduct domestic retail deposit...

  11. Changes in the level of micro RNA-206 gene expression in patients with type I bipolar disorder before and after treatment and comparison with a control population%双相障碍I型患者治疗前后微小RNA206基因表达水平变化及与对照的比较

    Institute of Scientific and Technical Information of China (English)

    汪作为; 李则挚; 王凌霄; 吴志国; 苑成梅; 洪武; 禹顺英; 方贻儒

    2011-01-01

    Micro RNA-206(miRNA-206) is a potential biomarker of bipolar disorder that has not yet been fully investigated.Objective:Assess the relationship between the level of miRNA-206 in peripheral blood and the clinical state of patients in the manic phase of bipolar disorder.Methods:Thirty-six newly admitted patients in the manic phase of type I bipolar disorder (diagnosed using the Structured Clinical Interview for DSM IV Axis I disorders) and 30 age and gender matched healthy controls were enrolled.miRNA-206 levels in peripheral blood lymphocytes were assessed at the time of enrollment in control subjects and at baseline and at the end of the second,fourth and eighth week of treatment in the patient group.The severity of manic symptoms in the patient group was evaluated at the same time as the miRNA-206 assessments using the Young Mania Rating Scale.Results:There were no statistically significant differences in baseline miRNA-206 levels between patients and controls (Z=-0.02,P =0.988) or,in the patient group,between baseline levels and those at the end of the second ( Z =-0.17,P =0.864),fourth ( Z =-0.86,P =0.392) and eighth ( Z =-1.29,P =0.197) weeks after initiating treatment.There were also no statistically significant correlations between the miRNA-206 level and the severity of manic symptoms at any of the four time points ( rs =0.13,P =0.518; rs =0.12,P =0.532; rs =-0.18,P =0.361 ;and rs =0.02,P=0.912; respectively).Conclusion:The activity of miRNA-206 in peripherally blood lymphocytes does not appear to be a biomarker of type I bipolar disorder or a biomarker for treatment efficacy during the treatment of a manic episode.But the power to detect differences between patients and controls in the study was only 22% so further research with larger samples ( possibly using different techniques to assess miRNA-206 activity) are needed to confirm these findings.%背景 微小RNA206( MicroRNA-206,miRNA-206)可能是双相障碍的生物学标志

  12. Analysis of prenatal diagnosis results of 206 thalassemia families%206例地中海贫血家系产前基因诊断结果分析

    Institute of Scientific and Technical Information of China (English)

    李莉艳; 钟梅; 陈翠华; 宋兰林; 靳旺杰; 王志坚

    2012-01-01

    Objective To summarize the geographical distribution,phenotype and genotype data of 206 thalassemia families underwent prenatal diagnosis to provide information for clinical genetic counseling and avoid the birth of severe thalassemia children. Methods Totally,206 thalassemia families were collected from Southern Medical University Nanfang Hospital from January 2008 to December 2009.Genomic DNA was extracted from peripheral blood,villus,amniotic fluid or cord blood from the couples or the fetuses.Gap-polymerase chain reaction (gap-PCR) and reverse dot blot (RDB) technology were used to detect the common α and β-thalassemia mutations.DNA sequencing was used to detect the rare mutations.Follow-up visit were done half a year after the fetuses were born. Results The 206 thalassemia families came from 12 provinces and areas across China,including Heilongjiang province.Mutations detected in α-thalassemia families included --SEA/,-α3.7/,-α4.2/,αCS α/ and αQS α/,which were all included in the testing kit. While there were 4 kinds of β-thalassemia mutations,Gγ+ (A γδβ)0,-28(A→C),CD54-58(-TATGGGCAACCCT) and CD37(G→A),could not be identified with routine testing kit. The 57 α-thalassemia families consisted of 11(19.3%) severe thalassemia,induding 8 Bart's hydrops syndrome and 3 Hb H disease,26(45.6%) heterozygote and 20(35.1%) normal infants,and the 149 β-thalassemia majors families consisted of 28 (18.8%) severe thalassemia,82(55.0%) heterozygote and 39 (26.2%) normal infants.Among the β-thalassemia heterozygotes,there was one 13-trisomy.Follow-up visit found that babies with Bart ' s hydrops syndrome (n =8),Hb H disease (n =3),β-thalassemia majors (n =28) and β thalassemia heterozygote combined with 13-trisomy(n=1) were aborted. Conclusions Thalassemia was found in some north area other than south of China,which should be paid more attention by clinicians.Gap-PCR and PCR-RDB technology are effective measures for thalassemia prenatal

  13. Organic Geochemical Stratum Characteristics from Memberl of Qingshankou Formation in the Well Mao 206 of Songliao Basin%松辽盆地茂206井青山口组一段有机地球化学特征

    Institute of Scientific and Technical Information of China (English)

    韩刚; 王敬岩; 张文婧; 黄清华

    2011-01-01

    The Songliao Basin was a large lacustrine one during Late Cretaceous,where the dark mudsones,shales and oil-shales of Qingshankou Formation were distributed widely and oilshales were considered as the primary marker beds of division and correlation in the basin.The dark shales and mudstones in Qingshankou Formation from well Mao 206 were of high organic carbon and low diasteranes contents.Organic geochemical characters were illustrated by biomarkers of gammacerane and positive excursion of kerogen isotopes.It is suggested that the dark mudstones and shales in the Member 1 of Qingshankou Formation are the products of lake anoxic in the extreme greenhouse climate period.Angiosperm farina at the bottom of Qingshankou Formation has significant era significance , it also proves that the age of the bottom of Qingshankou Formation in Songliao Basin should be Turonian and be not Cenomanian.%松辽盆地白垩纪青山口组下部分布一套富含有机碳的黑色泥岩、页岩和油页岩沉积,是全盆地划分泉头组与青山口组的一级标志.茂206井青山口组黑色泥岩、页岩的地球化学特征研究表明:它具有相对高的有机碳、干酪根碳同位素正偏、重排甾烷含量低,普遍存在伽玛蜡烷生物标志化合物等有机地球化学特征,表征为白垩纪温室效应时间窗内古湖泊缺氧事件的产物.而青山口组底部出现的一些具重要时代意义的被子植物花粉,也证实了青山口组底界已属Turonian期,而非Ceno-.manian期.

  14. Analysis of temperament characteristics of 206 infants aged 5~ 11 months%5~11个月婴儿气质特点206例分析

    Institute of Scientific and Technical Information of China (English)

    张永明

    2012-01-01

    [Objective] To investigate temperament characteristics of infants and guide parents to rear the infants and develop a good emotional response. [Method] 206 infants were surveyed with Carey's Temperament Questionnaire Scale. [Results] The proportion of infants with different temperament types in this district was 36. 2% for easy type and 41. 4% intermediate low child type,8. 6% for difficult type and 6. 7% for intermediate high child type and 7. 1 % for slow-to-warm up type of temperament. There were significant the cesarean section group and the spontaneous delivery group in distribution of all temperament types(x2 = 10. 391 ,P = 0. 034). There were no significant differences in gender dimensions of infant tem-perament(all P>0. 05). There were no significant gender differences in distribution of all temperament types(x2 = 5. 002,P = 0. 287). [Conclusion] To carry out the work of early childhood development, more attention should be paied to earlychildhood temperament characteristics.%[目的]了解婴儿气质特征,指导家长科学养育,培养婴儿良好的情绪、情感反应. [方法]采用《Carey5~11月婴儿气质问卷》,对西城区社区保健科206名5~11月婴儿进行调查分析. [结果]婴儿的主要气质类型分别为:易养型(36.2%)、中间偏易养型(41.4%)、困难型(8.6%)、启动缓慢型(7.1%)、中间偏难养型(6.7%).剖宫产婴儿与自然分娩婴儿气质特点的比较,差异有统计学意义(x2=10.391,P=0.034);不同性别婴儿气质维度中,男童与女童无显著性差异(P均>0.05);不同气质类型分布之间性别比较差异无统计学意义(x2=5.002,P=0.287). [结论]开展儿童早期综合发展工作,应重视早期儿童的气质特点.

  15. Fermentation of a new strain of food applied ice nucleation-active bacteria X.ampelina TS206%X.ampelina TS206发酵制备冰核活性蛋白的研究

    Institute of Scientific and Technical Information of China (English)

    刘健; 陈庆森; 阎亚丽; 王启明; 宋丽萍; 张群

    2002-01-01

    优化X anthomonas ampelina TS206的发酵制备条件可以提高冰核活性和生物量.通过摇瓶培养对该菌进行培养基成分和温度的筛选.实验结果表明:(1)鱼蛋白胨和乳糖的浓度对冰核活性的提高产生显著影响程度,玉米浆影响程度较小;(2)生物量影响程度大小的顺序依次为鱼蛋白胨>乳糖>甘油>玉米浆.优化的发酵培养基配方为:酵母粉10g/L、大豆蛋白胨10g/L、硫酸镁0.5g/L、蔗糖20g/L、鱼蛋白胨15g/L、乳糖1g/L、甘油20g/L、玉米浆10g/L,pH 7.0.其较优的发酵温度为18℃,发酵时间为48h,能获得较高的冰核活性和生物量.

  16. Neutron particle-hole electric dipole states in /sup 206/ /sup 207/ /sup 208/Pb. [16. 2 to 17. 8 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Dickey, P.A.

    1979-01-01

    Inelastic proton scattering on /sup 206/Pb, /sup 207/Pb, and /sup 208/Pb through isobaric analog resonances was used to study neutron particle-hole excitations with large ground-state gamma branches in these Pb isotopes. Relative (p,p') cross sections at 90/sup 0/ are extracted for structures selectively excited on the d/sub 5/2/, s/sub 1/2/, and d/sub 3/2/-g/sub 7/2/ resonances. Interpretation of excitations in /sup 206/Pb and /sup 207/Pb in terms of coupling to states in /sup 208/Pb is discussed. Branching ratios for 1/sup -/ states in /sup 208/Pb at 4.84, 5.29, 5.94, and 6.31 MeV and the 1/2/sup +/ state in /sup 207/Pb at 4.63 MeV are deduced. 15 figures, 4 tables.

  17. An Activin Receptor IA/Activin-Like Kinase-2 (R206H Mutation in Fibrodysplasia Ossificans Progressiva

    Directory of Open Access Journals (Sweden)

    Rafael Herrera-Esparza

    2013-01-01

    Full Text Available Fibrodysplasia ossificans progressiva (FOP is an exceptionally rare genetic disease that is characterised by congenital malformations of the great toes and progressive heterotopic ossification (HO in specific anatomical areas. This disease is caused by a mutation in activin receptor IA/activin-like kinase-2 (ACVR1/ALK2. A Mexican family with one member affected by FOP was studied. The patient is a 19-year-old female who first presented with symptoms of FOP at 8 years old; she developed spontaneous and painful swelling of the right scapular area accompanied by functional limitation of movement. Mutation analysis was performed in which genomic DNA as PCR amplified using primers flanking exons 4 and 6, and PCR products were digested with Cac8I and HphI restriction enzymes. The most informative results were obtained with the exon 4 flanking primers and the Cac8I restriction enzyme, which generated a 253 bp product that carries the ACVR1 617G>A mutation, which causes an amino acid substitution of histidine for arginine at position 206 of the glycine-serine (GS domain, and its mutation results in the dysregulation of bone morphogenetic protein (BMP signalling that causes FOP.

  18. Comparative study on the immunopotentiator effect of ISA 201, ISA 61, ISA 50, ISA 206 used in trivalent foot and mouth disease vaccine

    OpenAIRE

    Ibrahim, Ehab El-Sayed; Gamal, Wael Mossad; Hassan, Amr Ismail; Mahdy, Safy El-Din; Hegazy, Akram Zakria; Abdel-Atty, Magdy Mahmoud

    2015-01-01

    Aim: A comparison study was conducted to explore the best internationally available adjuvant that could be used in production of a highly potent foot and mouth disease (FMD) vaccine, that could stimulate a strong immune response and possibly give greater protection against FMD. Materials and Methods: Four experimental batches of trivalent FMD vaccine were prepared with different available oil adjuvants which included Montanide ISA 201, 206, 61 and 50. Results: The results indicated that vacci...

  19. Comparative study on the immunopotentiator effect of ISA 201, ISA 61, ISA 50, ISA 206 used in trivalent foot and mouth disease vaccine

    OpenAIRE

    Ehab El-Sayed Ibrahim; Wael Mossad Gamal; Amr Ismail Hassan; Safy El-Din Mahdy; Akram Zakria Hegazy; Magdy Mahmoud Abdel-Atty

    2015-01-01

    Aim: A comparison study was conducted to explore the best internationally available adjuvant that could be used in production of a highly potent foot and mouth disease (FMD) vaccine, that could stimulate a strong immune response and possibly give greater protection against FMD. Materials and Methods: Four experimental batches of trivalent FMD vaccine were prepared with different available oil adjuvants which included Montanide ISA 201, 206, 61 and 50. Results: The results indicated that...

  20. Endothelial Cells Can Regulate Smooth Muscle Cells in Contractile Phenotype through the miR-206/ARF6&NCX1/Exosome Axis

    OpenAIRE

    Lin, Xiao; He, Yu; Hou, Xue; Zhang, Zhenming; Wang, Rui; Wu, Qiong

    2016-01-01

    Active interactions between endothelial cells and smooth muscle cells (SMCs) are critical to maintaining the SMC phenotype. Exosomes play an important role in intercellular communication. However, little is known about the mechanisms that regulate endothelial cells and SMCs crosstalk. We aimed to determine the mechanisms underlying the regulation of the SMC phenotype by human umbilical vein endothelial cells (HUVECs) through exosomes. We found that HUVECs overexpressing miR-206 upregulated co...

  1. 粗山羊草抗条锈病新基因YrY206遗传分析和微卫星标记%Genetic Analysis and S S R Mapping on an New Stem Stripe Rust Resistance Gene YrY206 in Aegilops tauschii

    Institute of Scientific and Technical Information of China (English)

    张海泉; 郎杰; 马淑琴; 张宝石

    2008-01-01

    从小麦野生近缘属--粗山羊草中挖掘小麦条锈病抗病基因,拓展小麦抗病性的遗传基础.利用抗小麦条锈病与感小麦条锈病的粗山羊草间杂交,从粗山羊草[Aegilops tauschii(Coss.)Schmal]Y206中鉴定出1个显性抗小麦条锈病基因,暂定名为YrY206.应用分离群体分组法(Bulked segregantanalysis,BSA)筛选到Wmc11a、Xgwm71c、Xgwm161和Xgwm183标记,与该基因之间的遗传距离分别为4.0、3.3、1.5和9.3 cM.根据连锁标记所在小麦微卫星图谱的位置,YrY206被定位在3DS染色体上.分析基因所在染色体的位置、抗病性特征,认为YrY206是一个新的抗小麦条锈病基因.

  2. The RNA-binding Protein TDP-43 Selectively Disrupts MicroRNA-1/206 Incorporation into the RNA-induced Silencing Complex*♦

    Science.gov (United States)

    King, Isabelle N.; Yartseva, Valeria; Salas, Donaldo; Kumar, Abhishek; Heidersbach, Amy; Ando, D. Michael; Stallings, Nancy R.; Elliott, Jeffrey L.; Srivastava, Deepak; Ivey, Kathryn N.

    2014-01-01

    MicroRNA (miRNA) maturation is regulated by interaction of particular miRNA precursors with specific RNA-binding proteins. Following their biogenesis, mature miRNAs are incorporated into the RNA-induced silencing complex (RISC) where they interact with mRNAs to negatively regulate protein production. However, little is known about how mature miRNAs are regulated at the level of their activity. To address this, we screened for proteins differentially bound to the mature form of the miR-1 or miR-133 miRNA families. These muscle-enriched, co-transcribed miRNA pairs cooperate to suppress smooth muscle gene expression in the heart. However, they also have opposing roles, with the miR-1 family, composed of miR-1 and miR-206, promoting myogenic differentiation, whereas miR-133 maintains the progenitor state. Here, we describe a physical interaction between TDP-43, an RNA-binding protein that forms aggregates in the neuromuscular disease, amyotrophic lateral sclerosis, and the miR-1, but not miR-133, family. Deficiency of the TDP-43 Drosophila ortholog enhanced dmiR-1 activity in vivo. In mammalian cells, TDP-43 limited the activity of both miR-1 and miR-206, but not the miR-133 family, by disrupting their RISC association. Consistent with TDP-43 dampening miR-1/206 activity, protein levels of the miR-1/206 targets, IGF-1 and HDAC4, were elevated in TDP-43 transgenic mouse muscle. This occurred without corresponding Igf-1 or Hdac4 mRNA increases and despite higher miR-1 and miR-206 expression. Our findings reveal that TDP-43 negatively regulates the activity of the miR-1 family of miRNAs by limiting their bioavailability for RISC loading and suggest a processing-independent mechanism for differential regulation of miRNA activity. PMID:24719334

  3. Lead fluxes and 206Pb/207Pb isotope ratios in rime and snow collected at remote mountain-top locations (Czech Republic, Central Europe): Patterns and sources

    Science.gov (United States)

    Cimova, Nikoleta; Novak, Martin; Chrastny, Vladislav; Curik, Jan; Veselovsky, Frantisek; Blaha, Vladimir; Prechova, Eva; Pasava, Jan; Houskova, Marie; Bohdalkova, Leona; Stepanova, Marketa; Mikova, Jitka; Krachler, Michael; Komarek, Arnost

    2016-10-01

    During three winter seasons (2009-2011), Pb concentrations were measured in precipitation at 10 high-elevation sites in the Czech Republic, close to the borders with Austria, Germany, Poland, and Slovakia. Soluble and insoluble Pb forms were quantified in snow (vertical deposition), and rime (horizontal deposition). The objective was to compare Pb input fluxes into ecosystems via vertical and horizontal deposition, and to identify the residual Pb pollution sources in an era of rapidly decreasing industrial pollution. Lead soluble in diluted HNO3 made up 96% of total Pb deposition, with the remaining 4% Pb bound mainly in silicates. Three times higher concentrations of soluble Pb in rime than in snow, and 2.5 times higher concentrations of insoluble Pb in rime than in snow were associated with slightly different Pb isotope ratios. On average, the 206Pb/207Pb ratios in rime were higher than those in snow. Higher mean 206Pb/207Pb ratios of insoluble Pb (1.175) than in soluble Pb (1.165) may indicate an increasing role of geogenic Pb in recent atmospheric deposition. A distinct reversal to more radiogenic 206Pb/207Pb ratios in snow and rime in 2010, compared to literature data from rain-fed Sphagnum peatlands (1800-2000 A.D.), documented a recent decrease in anthropogenic Pb in the atmosphere of Central Europe. Since the early 1980s, Pb concentrations in snow decreased 18 times in the rural south of the Czech Republic, but only twice in the industrial north of the Czech Republic. Isotope signatures indicated that Pb in today's atmospheric deposition is mainly derived from Mesozoic ores mined/processed in Poland and coal combustion in the Czech Republic and Poland.

  4. CD206+ Cell Number Differentiates Influenza A (H1N1pdm09 from Seasonal Influenza A Virus in Fatal Cases

    Directory of Open Access Journals (Sweden)

    Heidi G. Rodriguez-Ramirez

    2014-01-01

    Full Text Available In 2009, a new influenza A (H1N1 virus affected many persons around the world. There is an urgent need for finding biomarkers to distinguish between influenza A (H1N1pdm09 and seasonal influenza virus. We investigated these possible biomarkers in the lung of fatal cases of confirmed influenza A (H1N1pdm09. Cytokines (inflammatory and anti-inflammatory and cellular markers (macrophages and lymphocytes subpopulation markers were analyzed in lung tissue from both influenza A (H1N1pdm09 and seasonal influenza virus. High levels of IL-17, IFN-γ, and TNF-α positive cells were identical in lung tissue from the influenza A (H1N1pdm09 and seasonal cases when compared with healthy lung tissue (P<0.05. Increased IL-4+ cells, and CD4+ and CD14+ cells were also found in high levels in both influenza A (H1N1pdm09 and seasonal influenza virus (P<0.05. Low levels of CD206+ cells (marker of alternatively activated macrophages marker in lung were found in influenza A (H1N1pdm09 when compared with seasonal influenza virus (P<0.05, and the ratio of CD206/CD14+ cells was 2.5-fold higher in seasonal and noninfluenza group compared with influenza A (H1N1pdm09 (P<0.05. In conclusion, CD206+ cells differentiate between influenza A (H1N1pdm09 and seasonal influenza virus in lung tissue of fatal cases.

  5. Studies on the Optimization of Fermentation Process Conditions of the Ice Nucleation-active Bacteria Xanthomonas ampelinaTS206%冰核活性细菌Xanthomonas ampelinaTS206实验室水平发酵生产工艺条件优化的研究

    Institute of Scientific and Technical Information of China (English)

    陈庆森; 宋丽萍; 阎亚丽; 庞广昌; 胡志和

    2005-01-01

    优化冰核活性细菌Xanthomonas ampelinaTS206实验室水平发酵生产的工艺条件为将冰核活性细菌应用在工业化生产提供了重要的技术资料.本文对冰核活性细菌Xanthomonas ampelinaTS206实验室水平的发酵生产工艺条件进行了系统的研究,结果表明这种冰核活性细菌的最适培养条件为:培养温度18℃,装液量40ml/250ml,摇床转速180r/min,接种量3%,发酵液的初始pH8.实验还确定了冰核活性细菌在发酵48h时达到对数生长期.采用上述发酵条件培养Xanthomonas ampelinaTS206可以使细菌在冰核活性不降低的条件下发酵液的菌体浓度达到2.87×1010个/ml,菌体干重增加了37.7%.

  6. Grazing-induced changes in muscle microRNA-206 and -208b expression in association with myogenic gene expression in cattle.

    Science.gov (United States)

    Horikawa, Akihiko; Ogasawara, Hideki; Okada, Kaito; Kobayashi, Misato; Muroya, Susumu; Hojito, Masayuki

    2015-11-01

    To investigate the roles of microRNAs (miRNAs) in muscle type conversion, the effects of 4 months of grazing on the expression levels of miRNAs and mRNAs associated with skeletal muscle development were analyzed by quantitative RT-PCR using the Biceps femoris muscle of Japanese Shorthorn cattle. After 4 months of grazing, the expression of muscle fiber type-associated miR-208b was higher in the grazed cattle than in the housed. In concordance with the pattern in miR-208b expression, the expression of MyoD, a myogenic regulatory factor associated with the shifting of muscle property to the fast type, was lower in the grazed cattle after 4 months of grazing than in the housed cattle. In addition, the expression of MyHC-2x (a fast type) was higher in the housed cattle than in the grazed, after 4 months of grazing. During the grazing period, miR-206 expression decreased in the housed cattle, whereas expression in the grazed cattle did not change, but rather remained higher than that of the housed cattle even at 3 months after the grazing ended. These miRNAs including miR-206 persisting with muscles of grazed cattle may be associated with regulation of muscle gene expression during skeletal muscle adaptation to grazing.

  7. Comparative study on the immunopotentiator effect of ISA 201, ISA 61, ISA 50, ISA 206 used in trivalent foot and mouth disease vaccine

    Directory of Open Access Journals (Sweden)

    Ehab El-Sayed Ibrahim

    2015-10-01

    Full Text Available Aim: A comparison study was conducted to explore the best internationally available adjuvant that could be used in production of a highly potent foot and mouth disease (FMD vaccine, that could stimulate a strong immune response and possibly give greater protection against FMD. Materials and Methods: Four experimental batches of trivalent FMD vaccine were prepared with different available oil adjuvants which included Montanide ISA 201, 206, 61 and 50. Results: The results indicated that vaccines emulsified using Montanide ISA 201 and Montanide ISA 206 adjuvants elicited a protective humoral immune response from the 2nd week postvaccination (WPV as for ISA 201 with serum neutralization test (SNT and enzyme-linked immune sorbent assay (ELISA antibody titers of 1.62±0.047a and 1.8±0.049a, 1.59±0.076a and 1.836±0.077a, and 1.71±0.06b and 1.96±0.074b for serotypes O, A, SAT2, respectively, and for ISA 206 at SNT and ELISA antibody titers of 1.5±0.082a and 1.84±0.084a, 1.56±0.037a and 1.818±0.052a, and 1.5±0.106a,b and 1.81±0.104a,b for FMD virus serotypes O, A and SAT2, respectively. For ISA 61 and ISA 50, the protective antibody titer appeared in the 3rd WPV. In the ISA 61 FMD vaccine, SNT and ELISA titer were 1.59±0.076a and 1.9±0.094a, 1.53±0.056a and 1.83±0.070a, and 1.5±0.082a and 1.84±0.094a for serotypes O, A and SAT2, respectively, and in the case of ISA 50 FMD vaccine, the SNT, and ELISA titer were recorded for serotypes O, A and SAT2 respectively, 1.59±0.037a and 1.8±0.030a, 1.68±0.056a,b and 1.916±0.065a,b, and 1.65±0.082a and 1.9±0.09a. On estimating the cellular immune response, the highest delta optical density levels for ISA 201 (0.395-0.460 and ISA 206 (0.375-0.428 were observed on 14 and 21 days post vaccination (DPV respectively, while the highest levels of lymphoproliferation for ISA 61 (0.375-0.455 and ISA 50 (0.411-0.430 were on 21 and 28 DPV, respectively. Conclusion: The duration of immunity from

  8. Comparative study on the immunopotentiator effect of ISA 201, ISA 61, ISA 50, ISA 206 used in trivalent foot and mouth disease vaccine

    Science.gov (United States)

    Ibrahim, Ehab El-Sayed; Gamal, Wael Mossad; Hassan, Amr Ismail; Mahdy, Safy El-Din; Hegazy, Akram Zakria; Abdel-Atty, Magdy Mahmoud

    2015-01-01

    Aim: A comparison study was conducted to explore the best internationally available adjuvant that could be used in production of a highly potent foot and mouth disease (FMD) vaccine, that could stimulate a strong immune response and possibly give greater protection against FMD. Materials and Methods: Four experimental batches of trivalent FMD vaccine were prepared with different available oil adjuvants which included Montanide ISA 201, 206, 61 and 50. Results: The results indicated that vaccines emulsified using Montanide ISA 201 and Montanide ISA 206 adjuvants elicited a protective humoral immune response from the 2nd week postvaccination (WPV) as for ISA 201 with serum neutralization test (SNT) and enzyme-linked immune sorbent assay (ELISA) antibody titers of 1.62±0.047a and 1.8±0.049a, 1.59±0.076a and 1.836±0.077a, and 1.71±0.06b and 1.96±0.074b for serotypes O, A, SAT2, respectively, and for ISA 206 at SNT and ELISA antibody titers of 1.5±0.082a and 1.84±0.084a, 1.56±0.037a and 1.818±0.052a, and 1.5±0.106a,b and 1.81±0.104a,b for FMD virus serotypes O, A and SAT2, respectively. For ISA 61 and ISA 50, the protective antibody titer appeared in the 3rd WPV. In the ISA 61 FMD vaccine, SNT and ELISA titer were 1.59±0.076a and 1.9±0.094a, 1.53±0.056a and 1.83±0.070a, and 1.5±0.082a and 1.84±0.094a for serotypes O, A and SAT2, respectively, and in the case of ISA 50 FMD vaccine, the SNT, and ELISA titer were recorded for serotypes O, A and SAT2 respectively, 1.59±0.037a and 1.8±0.030a, 1.68±0.056a,b and 1.916±0.065a,b, and 1.65±0.082a and 1.9±0.09a. On estimating the cellular immune response, the highest delta optical density levels for ISA 201 (0.395-0.460) and ISA 206 (0.375-0.428) were observed on 14 and 21 days post vaccination (DPV) respectively, while the highest levels of lymphoproliferation for ISA 61 (0.375-0.455) and ISA 50 (0.411-0.430) were on 21 and 28 DPV, respectively. Conclusion: The duration of immunity from Montanide ISA oils

  9. Mapping the boundaries of the seniority regime and collective motion: Coulomb excitation studies of N = 122 isotones $^{206}$Po and $^{208}$Rn

    CERN Multimedia

    Butler, P; Voulot, D; Rahkila, P J; Darby, I G; Grahn, T; Bree, N C F; Julin, R J; Diriken, J V J; Jenkins, D G; Kroell, T; Huyse, M L

    In regions near magic nuclei, seniority can be regarded as a good quantum number. In the N = 122 isotones above the Z = 82 shell closure relative high-$\\textit{j}\\,$ single-particle proton orbitals dominate the structure and thus levels up to $\\textit{I}$ = 2$\\textit{j}$ - 1 could, in principle, be understood within the seniority scheme. While B(E2) values usually increase within the band with increasing $\\textit{I}$, the seniority scheme can lead to a contrasting result. The present proposal addresses this phenomenon through the measurements of previously unknown B(E2; 0$^{+}\\rightarrow$ 2$^{+}$) values in $^{206}$Po and $^{208}$Rn. The proposed Coulomb excitation measurements of radioactive beams will be carried out at the REX-ISOLDE facility using the MINIBALL $\\gamma$-ray spectrometer.

  10. Advances in Interlaboratory Testing and Evaluation of Bituminous Materials State-of-the-Art Report of the RILEM Technical Committee 206-ATB

    CERN Document Server

    Bahia, Hussain; Canestrari, Francesco; Roche, Chantal; Benedetto, Hervé; Piber, Herald; Sybilski, Dariusz

    2013-01-01

    This STAR on asphalt materials presents the achievements of RILEM TC 206 ATB, acquired over many years of interlaboratory tests and international knowledge exchange. It covers experimental aspects of bituminous binder fatigue testing; the background on compaction methods and imaging techniques for characterizing asphalt mixtures including validation of a new imaging software; it focuses on experimental questions and analysis tools regarding mechanical wheel tracking tests, comparing results from different labs and using finite element techniques. Furthermore, long-term rutting prediction and evaluation for an Austrian road are discussed, followed by an extensive analysis and test program on interlayer bond testing of three different test sections which were specifically constructed for this purpose. Finally, the key issue of manufacturing reclaimed hot mix asphalt in the laboratory is studied and recommendations for laboratory ageing of bituminous mixtures are given.

  11. 来源于假单孢菌206植酸酶基因的克隆、表达及酶学性质研究%Gene Cloning, Expression and Characterization of an HAP Phytase from Pseudomonas fluorescens 206

    Institute of Scientific and Technical Information of China (English)

    李雅楠; 黄火清; 姚斌; 赵青; 刘昆; 马文康

    2013-01-01

    从浙江嘉兴人工鱼塘底泥样品筛选到产植酸酶活性较高的假单孢菌(Pseudomonas fluorescens)206.通过简并PCR和TAIL-PCR技术从Pseudomonas fluorescens 206菌株基因组DNA中克隆得到一个新的编码组氨酸酸性植酸酶(HAP)的基因,命名为phyP.该基因ORF全长1 284 bp,编码了427个氨基酸和一个终止密码子,前24个氨基酸为信号肽.将phyP在大肠杆菌中表达,重组蛋白经硫酸铵分级沉淀和阴离子交换柱纯化后达到电泳纯.对其酶学性质分析表明:重组植酸酶PhyP最适pH为5.5,在pH3.5-7.5的条件下具有较好的稳定性;重组植酸酶PhyP最适温度为45℃,在25℃时也具有较高的酶活性,因此植酸酶PhyP在饲料行业,尤其是水产行业具有潜在的应用前景.

  12. Influence of thermomechanical processing on biomechanical compatibility and electrochemical behavior of new near beta alloy, Ti-20.6Nb-13.6Zr-0.5V

    Directory of Open Access Journals (Sweden)

    Mohammed MT

    2015-10-01

    Full Text Available Mohsin Talib Mohammed,1 Zahid A Khan,1 Geetha Manivasagam,2 Arshad N Siddiquee1 1Mechanical Engineering Department, Faculty of Engineering, Jamia Millia Islamia, New Delhi, 2Centre for Biomaterials Science and Technology, VIT University, Vellore, India Abstract: This paper presents the results for the effect of different methods of thermomechanical processing on the mechanical properties and electrochemical behavior of metastable β alloy Ti-20.6Nb-13.6Zr-0.5V (TNZV. The thermomechanical processing included hot working, solution heat treatments at different temperatures, and cooling rates in addition to aging. The thermomechanical processing conditions used in the study resulted in attainment of a wide range of microstructures with varying spatial distributions and morphologies of elongated/equiaxed α, β phases, or martensite, as a result of which several tensile properties were achieved. Aging treatment led to an increase in hardness, elastic modulus, and tensile strength and a decrease in ductility (elongation. Electrochemical tests indicated that the TNZV alloy undergoes spontaneous passivation due to spontaneous formation of an oxide film in the environment of the human body. Because the air-cooled samples possessed high hardness and also a fine grain size, they showed a lower corrosion rate than the samples treated under other conditions. Keywords: titanium alloys, biomedical applications, mechanical properties, corrosion

  13. J-UNIO protocol used for NMR structure determination of the 206-residue protein NP-346487.1 from Streptococcus pneumoniae TIGR4

    Energy Technology Data Exchange (ETDEWEB)

    Jaudzems, Kristaps [Latvian Institute of Organic Synthesis (Latvia); Pedrini, Bill [Paul Scherrer Institute (PSI), SwissFEL Project (Switzerland); Geralt, Michael; Serrano, Pedro; Wüthrich, Kurt, E-mail: wuthrich@scripps.edu [The Scripps Research Institute, Department of Integrative Structural and Computational Biology (United States)

    2015-01-15

    The NMR structure of the 206-residue protein NP-346487.1 was determined with the J-UNIO protocol, which includes extensive automation of the structure determination. With input from three APSY-NMR experiments, UNIO-MATCH automatically yielded 77 % of the backbone assignments, which were interactively validated and extended to 97 %. With an input of the near-complete backbone assignments and three 3D heteronuclear-resolved [{sup 1}H,{sup 1}H]-NOESY spectra, automated side chain assignment with UNIO-ATNOS/ASCAN resulted in 77 % of the expected assignments, which was extended interactively to about 90 %. Automated NOE assignment and structure calculation with UNIO-ATNOS/CANDID in combination with CYANA was used for the structure determination of this two-domain protein. The individual domains in the NMR structure coincide closely with the crystal structure, and the NMR studies further imply that the two domains undergo restricted hinge motions relative to each other in solution. NP-346487.1 is so far the largest polypeptide chain to which the J-UNIO structure determination protocol has successfully been applied.

  14. J-UNIO protocol used for NMR structure determination of the 206-residue protein NP-346487.1 from Streptococcus pneumoniae TIGR4

    International Nuclear Information System (INIS)

    The NMR structure of the 206-residue protein NP-346487.1 was determined with the J-UNIO protocol, which includes extensive automation of the structure determination. With input from three APSY-NMR experiments, UNIO-MATCH automatically yielded 77 % of the backbone assignments, which were interactively validated and extended to 97 %. With an input of the near-complete backbone assignments and three 3D heteronuclear-resolved [1H,1H]-NOESY spectra, automated side chain assignment with UNIO-ATNOS/ASCAN resulted in 77 % of the expected assignments, which was extended interactively to about 90 %. Automated NOE assignment and structure calculation with UNIO-ATNOS/CANDID in combination with CYANA was used for the structure determination of this two-domain protein. The individual domains in the NMR structure coincide closely with the crystal structure, and the NMR studies further imply that the two domains undergo restricted hinge motions relative to each other in solution. NP-346487.1 is so far the largest polypeptide chain to which the J-UNIO structure determination protocol has successfully been applied

  15. Characterization of the ground X1 state of 204Pb19F, 206Pb19F, 207Pb19F, and 208Pb19F

    International Nuclear Information System (INIS)

    Pure rotational spectra of the ground electronic-vibrational X1 state of 204Pb19F, 206Pb19F, 207Pb19F, and 208Pb19F are measured with a resonator pulsed supersonic jet Fourier-transform microwave spectrometer. Also reported is a new measurement of the Stark effect on the optical spectra of A(leftarrow)X1 transitions. These spectra are combined with published high-resolution infrared spectra of X2↔X1 transitions in order to create a complete picture of the ground state of lead monofluoride. For the microwave data, molecules are prepared by laser ablation of lead target rods and stabilized in a supersonic jet of neon mixed with sulfur hexafluoride. For the optical Stark spectra, a continuous source of molecules is created in a nozzle heated to 1000 deg. C. The microwave spectra confirm, improve, and extend previously reported constants that describe the rotational, spin-orbit, and hyperfine interactions of the ground electronic state of the PbF molecule. A discrepancy concerning the sign of the hyperfine constant describing the 207Pb nucleus is discussed. Magnetic-field-dependent microwave spectra are used to characterize the Zeeman interaction in terms of two g factors of the body-fixed electronic wave function. The optical Stark spectra are used to characterize the electric dipole moment of the X1 and A states.

  16. Solid-State Transformation of Iron-Rich Intermetallic Phases in Al-Cu 206 Cast Alloys During Solution Heat Treatment

    Science.gov (United States)

    Liu, K.; Cao, X.; Chen, X.-G.

    2013-08-01

    The solid-state transformation of the iron-rich intermetallic phases in Al-Cu 206 cast alloys during the solution heat treatment was studied by using Scanning Electron Microscope (SEM), Electron Back Scattered Diffraction (EBSD), Differential Scanning Calorimeter (DSC), and Transmission Electron Microscope (TEM). At a normal solution treatment temperature of 793 K (520 °C), no visible variation is observed for the β-Fe phase solidified from the Al alloy melt. With increasing soaking time, however, the Chinese script α-Fe becomes unstable and progressively transforms into platelet β-Fe, termed as solid-state-transformed (STed) β-Fe to distinguish it from the β-Fe directly solidified from the Al alloy melt. The STed β-Fe preferentially nucleates on the α-Fe and then grows from the α-Fe/Al interface into α-Fe and/or Al matrix with a much higher growth rate in the α-Fe. The incomplete solid-state transformation from α-Fe into STed β-Fe leads to the fragmentation of the α-Fe. The formation of the STed β-Fe with increasing size and volume fraction after longer soaking time can deteriorate the tensile properties.

  17. Excitation functions of residual nuclei production from 40–2600 MeV proton-irradiated 206,207,208,natPb and 209Bi

    Indian Academy of Sciences (India)

    Yu E Titarenko; V F Batyaev; V M Zhivun; V O Kudryashov; K A Lipatov; A V Ignatyuk; S G Mashnik

    2007-02-01

    The work is aimed at experimental determination of the independent and cumulative yields of radioactive residual nuclei produced in intermediate-energy proton-irradiated thin targets made of highly isotopic enriched and natural lead (206,207,208,natPb) and 209Bi. 5972 radioactive product nuclide yields have been measured in 55 thin targets induced by 0.04, 0.07, 0.10, 0.15, 0.25, 0.6, 0.8, 1.2, 1.4, 1.6 and 2.6 GeV protons extracted from the ITEP U-10 proton synchrotron. The measured data have been compared with data obtained at other laboratories as well as with theoretical simulations by seven codes. We found that the predictive power of the tested codes is different but is satisfactory for most of the nuclides in the spallation region, though none of the codes agree well with the data in the whole mass region of product nuclides and all should be improved further.

  18. Studies on Fermentative Medium Formulation of Ice Nucleation-active Xanthomonas ampelinaTS206%Xanthomonas ampelina发酵培养基组成的优化

    Institute of Scientific and Technical Information of China (English)

    宋丽萍; 陈庆森; 闫亚丽; 刘健

    2003-01-01

    本文采用正交实验的方法优化了Xanthomonas ampelina TS206发酵培养基的配方,从而达到了提高冰核活性细菌发酵所得的生物量和细菌的冰核活性的目的.实验结果表明较优化的培养基配方为:牛肉膏3.0g/L、蛋白胨5.0g/L、甘油25.0g/L、蔗糖20.0g/L、山梨醇2.0g/L、酵母粉20.0g/L、玉米浆20.0g/L、K2HP04 1.5g/L、pH=7.0;最终发酵液的生物量达到8.2g/L(干重),冻滴率达到81%.

  19. Effect of Cultivation Condition on Xanthan Gum Ratio from Ice-nucleation Active Bacteria of Xanthomonas ampelina TS206%培养条件对冰核生产菌Xanthomonas ampelina TS206产胶率的影响

    Institute of Scientific and Technical Information of China (English)

    李鸿雁; 陈庆森; 阎亚丽; 刘磊; 崔维

    2005-01-01

    培养条件影响冰核细菌的生物量、冰核活性和产胶率.通过单因子试验确定了TS206的最适培养条件:最适装液量为100ml,培养基的最适起始pH值为7.0,最佳培养时间为48h,但是通过上述培养条件的调整并不能明显降低黄原胶的产率.采取从30℃到18℃的双温培养可以在保持较高的生物量和冰核活性的前提下,降低黄原胶的产量,并明显缩短了培养时间.

  20. Research of Card Management System Based on MSRE206 Reader and Writer-Taking Gymnasium at Colleges as a Case%基于MSRE206读写器的卡管理系统研究--以高校体育馆为例

    Institute of Scientific and Technical Information of China (English)

    纪玉玲; 于成江; 高军

    2014-01-01

    In order to meet the requirements of modern management technology, aiming at the low manual efficiency and error-prone problems at gymnasium management in colleges, this paper studies a card management system based on MSRE206 reader and writer. Through the analysis of system requirements, it emphatically describes the development process of C#-based gymnasium management system. Card processing is finished by card writer, which achieves the functions of card consumption, physical ability test and statis-tics. This system not only promotes the standardized management and improves the working efficiency, but also provides technical sup-port for physical education in colleges.%为适应现代化管理技术的要求,针对当前高校体育馆管理存在的人工效率低、容易出错等问题,研究了一种基于MSRE206读写器的卡管理系统。通过系统需求分析,着重阐述了基于C#的体育馆管理系统的开发过程。该系统通过写卡器办卡,实现了刷卡消费及体能测试和统计等功能,促进体育馆规范化管理,提高工作效率,为高校体育教学提供技术支持。

  1. Research of relative factors between bronchiolitis and asthma by long time follow-up of 206 children bronchiolitis patients%长期随访206例毛细支气管炎患儿发展为哮喘的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    刘志刚

    2014-01-01

    OBJECTIVE:206 children bronchiolitis patients with the hospitalization treatment were fol owed up long time, then the relative factors between bronchiolitis and asthma were analyzed. METHODS:The data of 206 children bronchiolitis patients with the hospitalization treatment were retrospectively analyzed. Al the children were fol owed up for three years. Sex, family history,childbirth,feeding pat erns,al ergy history,immunoglobulin,intestinal tract probiotics,inhaled corticosteroid,al ergic constitution, repeat respiratory tract infections and passive smoking were observed. Logistic regression analysis was used to analyze the relationship between the factors and asthma. RESULTS:48 of 206 patients (23.3%) with bronchiolitis converted to asthma. Univariate analysis results showed that there were significant difference of family history, immunoglobulin, feeding pat erns, inhaled corticosteroid, al ergic constitution and passive smoking between the chil-dren with or without asthma (P﹤0.05). Logistic regression analysis showed that family history, al ergic constitution , repeat respiratory tract infections and passive smoking were the risk factors for asthma, and breast feeding,inhaled corticosteroid, repeat respiratory tract infections and immunoglobulin were the protective factors. CONCLUSION:Family history, Individual al ergic constitution,respiratory tract infections and passive smoking were the risk factors for asthma. Breast feed-ing,inhaled corticosteroid treatment , intestinal tract probiotics and immunoglobulin wil decrease the occurrence of asthma.%目的:对住院治疗的206例毛细支气管炎患儿进行随访2年,对其中可能是发展为哮喘的影响因素进行分析。方法:对住院治疗的206例毛细支气管炎患儿临床资料进行回顾性分析,所有患儿均随访2年。对性别、家族史、生产史、喂养史、过敏史、丙种球蛋白、益生菌应用史、吸入糖皮质激素及被动吸烟可能是发展为哮

  2. Suzaku View of the Swift/BAT Active Galactic Nuclei. V. Torus Structure of Two Luminous Radio-Loud Active Galactic Nuclei (3C 206 and PKS 0707-35)

    Science.gov (United States)

    Tazaki, Fumie; Ueda, Yoshihiro; Terashima, Yuichi; Mushotzky, Richard F.; Tombesi, Francesco

    2013-01-01

    We present the results from broadband X-ray spectral analysis of 3C 206 and PKS 0707-35 with Suzaku and Swift/BAT, two of the most luminous unobscured and obscured radio-loud active galactic nuclei (AGNs) with hard X-ray luminosities of 10(sup 45.5) erg per second and 10(sup 44.9) erg per second (14-195 keV), respectively. Based on the radio core luminosity, we estimate that the X-ray spectrum of 3C 206 contains a significant (60% in the 14-195 keV band) contribution from the jet, while it is negligible in PKS 0707-35.We can successfully model the spectra with the jet component (for 3C 206), the transmitted emission, and two reflection components from the torus and the accretion disk. The reflection strengths from the torus are found to be R(sub torus)(=Omega/2pi) = 0.29 +/- 0.18 and 0.41 +/- 0.18 for 3C 206 and PKS 0707-35, respectively, which are smaller than those in typical Seyfert galaxies. Utilizing the torus model by Ikeda et al., we quantify the relation between the half-opening angle of a torus (theta(sub oa)) and the equivalent width of an iron-K line. The observed equivalent width of 3C 206, less than 71 eV, constrains the column density in the equatorial plane to N(sup eq)(sub H) lesst han 10(sup 23) per square centimeter, or the half-opening angle to theta(sub oa) greater than 80 deg. if N(sup eq)(sub H) = 10(sup 24) per square centimeter is assumed. That of PKS 0707-35, 72 +/- 36 eV, is consistent with N(sup eq)(sub H) 10(sup 23) per square centimeter. Our results suggest that the tori in luminous radio-loud AGNs are only poorly developed. The trend is similar to that seen in radio-quiet AGNs, implying that the torus structure is not different between AGNs with jets and without jets.

  3. Line parameters including temperature dependences of air- and self-broadened line shapes of 12C16O2: 2.06-μm region

    Science.gov (United States)

    Benner, D. Chris; Devi, V. Malathy; Sung, Keeyoon; Brown, Linda R.; Miller, Charles E.; Payne, Vivienne H.; Drouin, Brian J.; Yu, Shanshan; Crawford, Timothy J.; Mantz, Arlan W.; Smith, Mary Ann H.; Gamache, Robert R.

    2016-08-01

    This study reports the results from analyzing a number of high resolution, high signal-to-noise ratio (S/N) spectra in the 2.06-μm spectral region for pure CO2 and mixtures of CO2 in dry air. A multispectrum nonlinear least squares curve fitting technique has been used to retrieve the various spectral line parameters. The dataset includes 27 spectra: ten pure CO2, two 99% 13C-enriched CO2 and fifteen spectra of mixtures of 12C-enriched CO2 in dry air. The spectra were recorded at various gas sample temperatures between 170 and 297 K. The absorption path lengths range from 0.347 to 49 m. The sample pressures for the pure CO2 spectra varied from 1.1 to 594 Torr; for the two 13CO2 spectra the pressures were ∼10 and 146 Torr. For the air-broadened spectra, the pressures of the gas mixtures varied between 200 and 711 Torr with CO2 volume mixing ratios ranging from 0.014% to 0.203%. The multispectrum fitting technique was applied to fit simultaneously all these spectra to retrieve consistent set of line positions, intensities, and line shape parameters including their temperature dependences; for this, the Voigt line shape was modified to include line mixing (via the relaxation matrix formalism) and quadratic speed dependence. The new results are compared to select published values, including recent ab initio calculations. These results are required to retrieve the column averaged dry air mole fraction (XCO2) from space-based observations, such as the Orbiting Carbon Observatory-2 (OCO-2) satellite mission that NASA launched in July 2014.

  4. Tolerogenic responses of CD206+, CD83+, FOXP3+, and CTLA-4 to sericin/polyvinyl alcohol/glycerin scaffolds relevant to IL-33 and HSP60 activity.

    Science.gov (United States)

    Ampawong, Sumate; Aramwit, Pornanong

    2016-09-01

    Silk sericin-releasing (sericin/polyvinyl alcohol (PVA)/glycerin) scaffolds have been designed for wound dressing applications using different fabrication techniques that influence scaffold antigenicity. The immunological tolerance of scaffolds depends on the balance of immunogenic and tolerogenic responses modulated by dendritic cells (DCs). An in vivo skin implantation model was used to compare the tolerogenic effect of sericin/PVA/glycerin scaffolds prepared by freeze-drying versus salt-leaching techniques, using an Allevyn® scaffold as a control. Immunohistochemical and histopathological studies were performed to evaluate tolerogenic DCs (CD206+), immunogenic DCs (CD83+), regulatory T-cells (FOXP3+ and CTLA-4), a proinflammatory cytokine (interleukin 33: IL-33), a stress marker (heat shock protein 60; HSP60), histopathological changes and related inflammatory cells. It was found that both sericin/PVA/glycerin scaffolds were tolerogenic and induced early activated Treg functions, while the Allevyn® scaffold was immunogenic. However, the tolerance of the freeze-dried sericin/PVA/glycerin scaffolds was not as consistent as the salt-leached sericin/PVA/glycerin scaffolds, indicated by the low level of CTLA-4 expression. This was probably due to molecular cross-linking and the morphological and mechanical properties of the freeze-drying technique, which would enhance the immune response. Severe inflammatory responses (including mast cell degranulation and foreign body giant cell accumulation) and histopathological changes (including fat infiltration and fibrosis formation) were mainly found with the Allevyn® scaffold, presumably from its architecture and chemical composition, especially polyurethane. The up-regulation of IL-33 and HSP60 with the Allevyn® scaffold was correlated with the inflammatory and pathological levels. Our findings suggested that salt-leached sericin/PVA/glycerin scaffolds were tolerogenic, induced a low inflammatory response and were

  5. 磷酸奥司他韦预防甲型H1N1流感时引起不良反应206例报道%Report of 206 cases of adverse drug reactions in using oseltamivir to prevent influenza A H1N1 influenza

    Institute of Scientific and Technical Information of China (English)

    董伟; 王艳彩

    2011-01-01

    AIM To analyse the adverse drug reactions (ADRs) occurred in people who took oseltamivir phosphate to prevent influenza A H1N1 influenza. METHODS The ADRs of 2 978 cases who took oseltamivir phosphate 75 mg once daily for 7 d to prevent influenza A H1N1 influenza were recorded every day and 2 790 cases with intact data were carried out statistical analysis. RESULTS There were 206 cases of ADRs, with the total ADRs incidence rate of 7.38%. Cases with the main clinical manifestations of enteron symptoms such as diarrhea, nausea, and bellyache etc.were 157, with the incidence rate of 5.62%. The incidenec rate of ADRs was low in rash, otalgia, tachycardia, foreign body sensation of esophagus and nosebleed and insomnia etc. CONCLUSION The ADRs of oseltamivir phosphate in the prevention of influenza A HIN1 influenza mainly were enteron symptoms which do not affect the treatment in general. But if such symptoms as rash or tachyeardia occur, the drug should be immediately stopped and symptomatic treatment must be given.%目的 分析磷酸奥司他韦预防甲型H1N1流感时人群不良反应发生情况.方法 对2978例服用磷酸奥司他韦75㎎,qd,共7 d预防甲型H1N1型流感者逐日记录其不良反应并将2790例资料完整者进行分析统计.结果 206例出现不良反应,总不良反应发生率为7.38%,以腹泻、恶心、腹痛等消化道症状为主,共157例,发生率为5.62%.皮疹、耳痛、心动过速、食管异物感、鼻出血、失眠等发生率低.结论 磷酸奥司他韦预防甲型H1N1流感时不良反应以消化道症状为主,一般不影响治疗.如出现皮疹、心动过速等应停药并给予对症处理.

  6. Improved 206Pb/238U microprobe geochronology by the monitoring of a trace-element-related matrix effect; SHRIMP, ID-TIMS, ELA-ICP-MS and oxygen isotope documentation for a series of zircon standards

    Science.gov (United States)

    Black, L.P.; Kamo, S.L.; Allen, C.M.; Davis, D.W.; Aleinikoff, J.N.; Valley, J.W.; Mundil, R.; Campbell, I.H.; Korsch, R.J.; Williams, I.S.; Foudoulis, C.

    2004-01-01

    Precise isotope dilution-thermal ionisation mass spectrometry (ID-TIMS) documentation is given for two new Palaeozoic zircon standards (TEMORA 2 and R33). These data, in combination with results for previously documented standards (AS3, SL13, QGNG and TEMORA 1), provide the basis for a detailed investigation of inconsistencies in 206Pb/238U ages measured by microprobe. Although these ages are normally consistent between any two standards, their relative age offsets are often different from those established by ID-TIMS. This is true for both sensitive high-resolution ion-microprobe (SHRIMP) and excimer laser ablation-inductively coupled plasma-mass spectrometry (ELA-ICP-MS) dating, although the age offsets are in the opposite sense for the two techniques. Various factors have been investigated for possible correlations with age bias, in an attempt to resolve why the accuracy of the method is worse than the indicated precision. Crystallographic orientation, position on the grain-mount and oxygen isotopic composition are unrelated to the bias. There are, however, striking correlations between the 206Pb/238U age offsets and P, Sm and, most particularly, Nd abundances in the zircons. Although these are not believed to be the primary cause of this apparent matrix effect, they indicate that ionisation of 206Pb/238U is influenced, at least in part, by a combination of trace elements. Nd is sufficiently representative of the controlling trace elements that it provides a quantitative means of correcting for the microprobe age bias. This approach has the potential to reduce age biases associated with different techniques, different instrumentation and different standards within and between laboratories. Crown Copyright ?? 2004 Published by Elsevier B.V. All rights reserved.

  7. 20.6.Cerebrovascular disease

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930388 A study on the activity of three antiox-idant enzymes in the brain of experimental acutecerebral ischemia.BAI Yun (白云),et al.LabNeurochemist,Tianjin Neurol Instit,Tianjin,300052.Chin J Neurol & Psychiat 1992;25 (6):351—354.The activities of superoxide dismutase (SOD),glutathione peroxidase (GSH—Px) and catalase(CAT) in the ischemic cerebral tissue followingthe unilateral middle cerebral artery occlusion ofrats were assessed.In comparison with the sham—operated rats,both SOD and GSH—Px activi-ty in the ischemic area (striatum and temporalcortex) were significantly reduced by 30min ofischemia,GSH—Px activity in the peri-is-

  8. 急诊深静脉穿刺置管206例临床分析%Application of emergency deep venous catheterization outside the operation room

    Institute of Scientific and Technical Information of China (English)

    祝义军; 封卫征; 史东平

    2007-01-01

    Objective To evaluate the advantages and disadvantages of inserted internal jugular vein cathe-ters and femoral vein catheters in emergency patients outside the operation room.Methods 206 patients received right internal vein catheterization(group J,n=110)and right femoral vein catheterization(group F,n=96).Suc-cessful rates of puncture,operation time,incidence of complications were observed and compared between the two groups.SAS6.04 software was used to analyze the data of the two groups.Results Emergency deep venous catheter-ization was accomplished in all the patients.There were no severe complication in two groups,such as pneumothorax and cardiac arrest.The rate of successful puncture in group J was 88%(97/110),however,100%(96/96)in group F.There was statistical significant difference between two groups(P<0.05).Mean time needed in group J (21.5±8.4)m was more than that in group F(12.5±5.3)min(P<0.05).The cases of puncturing into artery or serious arrhythmia in group F(2 cases)were less than that in group J(7 cases including hematoma in 4 cases)(P<0.05).6 cases were found to have arrhythmia in group J but there was not arrhythmia in group F(P<0.05).Con-chsion Different ways of emergency deep venous catheterization should be selected according to different condi-tions of patients outside the operation room.For critically ill patients,femoral vein puncture is more safe,with high rate of Success and less complication.%目的 比较手术室外行急诊颈内静脉与股静脉穿刺置管的优缺点.方法 手术室外行急诊深静脉穿刺置管患者206例,按照首次穿刺的血管分为右颈内静脉组110例和右股静脉组96例.分别记录2组的首次置管成功率、操作完成时间和并发症发生情况.采用SAS 6.04软件包对2组数据行t检验和非参数统计分析.结果 2组患者的病情、年龄、体重、性别相似,最终均完成深静脉穿刺置管,无气胸、心跳骤停等发生.右颈内静脉组首次成功率为88

  9. Introduction of EU No. 626/2011 and EU No. 206/2012%欧盟空调及热泵新能源标签指令及ErP指令介绍

    Institute of Scientific and Technical Information of China (English)

    钟文初

    2013-01-01

    EU No. 626/2011 supplementing Directive 2010/30/EU of the European Parliament and of the Council with regard to energy labelling of air conditioners for air conditioning and heat pump and EU No. 206/2012 implementing Directive 2009/125/EC of the European Parliament and of the Council with regard to ecodesign requirements for air conditioners and comfort fans officially implemented in 2013. These two directives adopted a new assessment methods and concepts for the energy efficiency performance of air conditioning and heat pump. This article focuses on introductions for both directives and provides designer a better understanding of the EU's new requirements for such products.%  欧盟针对空调及热泵产品的新能源标签指令(EU No.626/2011)和ErP指令的实施方法(EU No.206/2012)于2013年1月正式实施。这两个指令采用了新的评估方法和理念对空调及热泵产品进行节能评估。本文着重对这两个指令进行介绍阐述,帮助设计开发人员更好的理解欧盟对于这类产品的新要求。

  10. Stable (206Pb, 207Pb, 208Pb) and radioactive (210Pb) lead isotopes in 1 year of growth of Sphagnum moss from four ombrotrophic bogs in southern Germany: Geochemical significance and environmental implications

    Science.gov (United States)

    Shotyk, William; Kempter, Heike; Krachler, Michael; Zaccone, Claudio

    2015-08-01

    The surfaces of Sphagnum carpets were marked with plastic mesh and 1 year later the production of plant matter was harvested in four ombrotrophic bogs from two regions of southern Germany: Upper Bavaria (Oberbayern, OB) and the Northern Black Forest (Nordschwarzwald, NBF). Radioactive, 210Pb was determined in solid samples using ultralow background gamma spectrometry while total Pb concentrations and stable isotopes (206Pb, 207Pb, 208Pb) were determined in acid digests using ICP-SMS. Up to 12 samples (40 × 40 cm) were collected per site, and 6-10 sites investigated per bog. The greatest variations within a given sampling site were in the range 212-532 Bq kg-1 for 210Pb activity, whereas 206Pb/207Pb and 208Pb/206Pb varied less than 1%. The median values of all parameters for the sites (6-10 per bog) were not significantly different. The median activities of 210Pb (Bq kg-1) in the mosses collected from the bogs in NBF (HO = 372 ± 56, n = 55; WI = 342 ± 58, n = 93) were slightly less from those in OB (GS = 394 ± 50, n = 55; KL = 425 ± 58, n = 24). However, the mosses in the NBF bogs exhibited much greater productivity (187-202 g m-2 a-1) compared to those of OB (71-91 g m-2 a-1), and this has a profound impact on the accumulation rates of 210Pb (Bq m-2 a-1), with the bogs in the NBF yielding fluxes (HO = 73 ± 30; WI = 65 ± 20) which are twice those of OB (GS = 29 ± 11; KL = 40 ± 13). Using the air concentrations of 210Pb measured at Schauinsland (SIL) in the southern Black Forest and average annual precipitation, the atmospheric fluxes of 210Pb at SIL (340 Bq m-2 a-1) exceeds the corresponding values obtained from the mosses by a factor of five, providing the first quantitative estimate of the net retention efficiency of 210Pb by Sphagnum. When the 210Pb activities of all moss samples are combined (n = 227), a significant decrease with increasing plant production rate is observed; in contrast, total Pb concentrations show the opposite trend. The contrasting

  11. Distribution of pathogens and their antibiotic resistance in 206 elderly patients with nosocomial lower respiratory tract infections%206例老年人下呼吸道院内感染的病原菌分布及耐药性调查

    Institute of Scientific and Technical Information of China (English)

    奚菁颖; 童如镜; 宋钟娟; 王璐华; 沈杰; 庞立峰

    2005-01-01

    目的了解老年人院内下呼吸道感染病原菌的分布及耐药状况,为临床合理应用抗菌药物提供参考.方法采用纸片琼脂扩散法(K-B Test),按2000年美国国家临床实验室标准化委员会(NCCLS)药敏试验标准判断结果.结果2002年3月至2003年5月干部病房206例老年院内下呼吸道感染患者的痰液及经气管切开取得的痰液标本培养分离所得病原菌285株,以革兰阴性菌为主,其中非发酵菌中假单胞菌属菌株对第3代头孢菌素耐药率普遍较高(41.18%~93.75%),而对碳青霉烯类耐药率稍低;不动杆菌属对碳青霉烯类、头孢哌酮-舒巴坦、头孢他啶等敏感性较好;大肠埃希菌、克雷伯菌属、肠杆菌属等肠杆菌科细菌对第3代头孢菌素耐药率均很高;除肠杆菌属外其他肠杆菌科细菌对碳青霉烯类均较敏感.结论本院干部病房老年人院内下呼吸道感染主要病原菌为革兰阴性杆菌,其对常用抗菌药物的耐药性呈上升趋势.

  12. Endovenous laser plus stab avulsion in the treatment of lower-limb varicose veins%腔内激光联合点式剥脱治疗下肢浅静脉曲张206

    Institute of Scientific and Technical Information of China (English)

    车星; 朱网林; 戴翔; 桑凯

    2013-01-01

    Objective To explore the advantages of endovenous laser plus stab avulsion in the treatment of lower-limb varicose veins. Methods Between July 1, 2010, and June 31, 2012, 206 patients with a total of 267 lower limbs were submitted to EVLT plus a surgical approach. Results The follow-up from 1 month to 25 months showed no recurrence and no clinical symptoms or signs. After treatment, the edema and itching disappeared, the pigmentation reduced, and all the ulcers healed. Conclusion Endovenous laser plus stab avulsion not only ensure the curative effect, but also achieve the purpose of minimally invasive in the treatment of lower-limb varicose veins.%目的 探讨腔内激光联合点式剥脱治疗下肢浅静脉曲张的优势.方法 2010 年7 月至2012 年7月,206 例患者共267 条患肢确诊为下肢浅静脉曲张,采取腔内激光联合手术治疗.结果 术后随访1~25 个月,所有患肢曲张静脉消失,未见复发,肿胀消退,瘙痒消失,色素沉着有所减轻,溃疡均愈合.结论 腔内激光联合手术治疗下肢浅静脉曲张,其在保证疗效的同时,达到了微创的目的.

  13. Comparison of Montanide adjuvants, IMS 3012 (Nanoparticle), ISA 206 and ISA 35 (Emulsion based) along with incomplete Freund's adjuvant for hyperimmunization of equines used for production of polyvalent snake antivenom.

    Science.gov (United States)

    Waghmare, Arun; Deopurkar, R L; Salvi, Nitin; Khadilkar, Milind; Kalolikar, Milind; Gade, S K

    2009-02-11

    The use of adjuvant is of fundamental importance in vaccines formulations and antisera production. Currently selection and use of adjuvant systems in snake antivenom preparation has become a major issue in terms of animal welfare as well as economics. In order to minimize disadvantages associated with traditionally used Freund's adjuvant (FA) in equines and to produce potent polyvalent antivenom against four Indian snake venoms in minimum possible period, a comparison was made between various commercially available non-emulsion/emulsion based adjuvants like IMS 3012, ISA 206 and ISA 35 with Incomplete Freund's adjuvant (IFA) for their immunopotentiation capacity and safety in donor animals. The present study was conducted in 33 new horses, randomly divided into four groups and hyperimmunized using crude mixture of snake venoms, viz.; Cobra venom (CV), Russell's viper venom (RV), Krait venom (KV) and Saw-scaled viper (EV) along with four above mentioned adjuvants through subcutaneous (s.c.) route at intervals of two weeks. Periodic standard safety assessments were done. Immunopotentiation ability of each adjuvant group in terms of percent responders were estimated at 14th, 21st, 30th and 43rd week. The neutralization activity (ED(50)) of pooled sera samples by 43(rd) week, obtained with IMS 3012 group for CV, RV, KV and EV venoms were 0.133, 0.143, 0.070 and 0.270 mg venom/ml of serum respectively. The antivenom potency with IMS 3012 and overall responding horses (100%) even against weak immunogen like CV was significantly higher (p<0.05) than other three adjuvants studied. The horses of IMS 3012 group showed minimum local reactions at injection site, while horses from other three groups exhibited moderate (++) reactions; 66.7% in ISA 206, 12.5% in ISA 35 and 14.3% in IFA respectively, however these were transient and reabsorbed or healed subsequently. Finally, we conclude that, nanoparticle adjuvant IMS 3012 could be a possible alternative to the emulsion adjuvants

  14. Altered Activities of Cysteine Desulfurase Variants H104Q, E156Q, D180G,Q183E and K206A Caused by Changes in Pyridoxal Phosphate Binding%半胱氨酸脱硫酶突变体H104Q,E156Q,D180G,Q183E和K206A通过改变对磷酸吡哆醛的结合影响酶活性

    Institute of Scientific and Technical Information of China (English)

    张婷; 李唐; 赵津; 谭国强

    2015-01-01

    大肠杆菌半胱氨酸脱硫酶(cysteine desulfurase,IscS)是一类依赖磷酸吡哆醛(pyridoxal phosphate,PLP)的同质二聚体的酶.IscS能催化游离底物L-半胱氨酸脱硫,生成L-丙氨酸和单质硫.在此催化过程中,可形成与酶结合的半胱氨酸过硫化物中间物,并出现了7种具有不同特征性吸收峰的中间反应物.为了研究PLP的结合及中间反应物的形成及累积,对IscS中与PLP结合相关,及IscS半胱氨酸活性口袋中特定氨基酸残基位点(His104,Glu156,Asp180,Gln183和Lys206)进行定点突变,结果发现:1)IscS突变体H104Q、D180G、Q183E、K206A对PLP的结合能力具有不同程度的减弱,酶的活性明显降低甚至消失,PLP与蛋白结合的特异吸收峰消失,或发生明显偏移并出现新的吸收峰,且这些新出现的吸收峰又与蛋白形成的各种中间反应物的吸收峰一致;2)IscS突变体E156Q的活性增高,PLP与蛋白结合的吸收峰明显增加.这些结果都表明,IscS氨基酸残基可通过影响PLP的结合及质子转移引起催化过程中不同中间反应物的形成及累积,同时提高或降低蛋白的活性.

  15. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  16. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  17. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  18. Rb-Sr and single - zircon grain 207Pb / 206Pb chronology of the Monesterio granodiorite and related migmatites. Evidence of a Late Cambrian melting event in the Ossa-Morena Zone, Iberian Massif

    Directory of Open Access Journals (Sweden)

    Bea, F.

    1999-04-01

    Full Text Available The Monesterio granodiorite, a small granodioritic body placed in a migmatitic complex in the SW of the Olivenza-Monesterio antiform, is a key plutonic body to understanding the relationships among the magmatism, metamorphism, and deformation in the Ossa-Morena Zone, SW Iberian Massif. We dated the granodiorite with the single zircon stepwise-evaporation 207Pb/206Pb method, and the related migmatization event with the Rb-Sr method on leucosomes. Our results indicate that the Monesterio granodiorite crystallised at 510 ± 7 Ma and its protolith had a component with Upper Proterozoic zircons with a minimum age of 1696 Ma. Leucosomes give a Rb-Sr age of 511 ± 40 Ma (MSWD =1,7 with initial 87Sr/86Sr =0.70914 ± 0.00048. The lower initial 87Sr/86Sr of the granodiorite and its calc-alkaline chemistry precludes it from having derived from the same protolith as the migmatites. The existence of different magmatic bodies in the Ossa-Morena Zone with ages clustering around 500-510 Ma reveals the existence of a significant melting event during the Late Cambrian that involved protoliths with very different geochemical and isotopic signatures.La granodiorita de Monesterio es un pequeño cuerpo emplazado en un complejo migmatítico en el SO del antiforme Olivenza-Monesterio, importante para entender las relaciones entre magmatismo, metamorfismo y deformación en la Zona de Ossa-Morena. Se ha datado la granodiorita por el método de evaporación secuencial de 207Pb/206Pb en cristal único de circón y los leucosomes de las migmatitas circundantes por el método Rb-Sr. Los datos indican una edad de cristalización de la granodiorita de 510 ± 4 Ma y un posible protolito Proterozoico Superior con una edad mínima de ∼1.700 Ma, obtenida a partir de núcleos heredados de los circones analizados. Los leucosomes dan una edad Rb-Sr de 511 ± 40 Ma, con una relación 87Sr/86Sr=0,70914 ± 0,00048. La relación inicial de 87Sr/86Sr en la granodiorita (

  19. Characterization of the ground X{sub 1} state of {sup 204}Pb{sup 19}F, {sup 206}Pb{sup 19}F, {sup 207}Pb{sup 19}F, and {sup 208}Pb{sup 19}F

    Energy Technology Data Exchange (ETDEWEB)

    Mawhorter, Richard J.; Murphy, Benjamin S.; Baum, Alexander L.; Sears, Trevor J.; Yang, T.; Rupasinghe, P. M; McRaven, C. P.; Shafer-Ray, N. E.; Alphei, Lukas D.; Grabow, Jens-Uwe [Department of Physics and Astronomy, Pomona College, Claremont, California 91711-6327 (United States); Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973-5000 (United States); Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, Norman, Oklahoma (United States); Gottfried-Wilhelm-Leibniz-Universitaet, Institut fuer Physikalische Chemie and Elektrochemie, Lehrgebiet A, D-30167 Hannover (Germany)

    2011-08-15

    Pure rotational spectra of the ground electronic-vibrational X{sub 1} state of {sup 204}Pb{sup 19}F, {sup 206}Pb{sup 19}F, {sup 207}Pb{sup 19}F, and {sup 208}Pb{sup 19}F are measured with a resonator pulsed supersonic jet Fourier-transform microwave spectrometer. Also reported is a new measurement of the Stark effect on the optical spectra of A(leftarrow)X{sub 1} transitions. These spectra are combined with published high-resolution infrared spectra of X{sub 2}{r_reversible}X{sub 1} transitions in order to create a complete picture of the ground state of lead monofluoride. For the microwave data, molecules are prepared by laser ablation of lead target rods and stabilized in a supersonic jet of neon mixed with sulfur hexafluoride. For the optical Stark spectra, a continuous source of molecules is created in a nozzle heated to 1000 deg. C. The microwave spectra confirm, improve, and extend previously reported constants that describe the rotational, spin-orbit, and hyperfine interactions of the ground electronic state of the PbF molecule. A discrepancy concerning the sign of the hyperfine constant describing the {sup 207}Pb nucleus is discussed. Magnetic-field-dependent microwave spectra are used to characterize the Zeeman interaction in terms of two g factors of the body-fixed electronic wave function. The optical Stark spectra are used to characterize the electric dipole moment of the X{sub 1} and A states.

  20. 21 CFR 131.206 - Nonfat yogurt.

    Science.gov (United States)

    2010-04-01

    ... destroy viable microorganisms. (b) Vitamin addition (optional). (1) If added, vitamin A shall be present... International Units thereof, within limits of good manufacturing practice. (2) If added, vitamin D shall be...-treated after culturing. (iii) The phrase “vitamin A” or “vitamin A added”, or “vitamin D” or “vitamin...

  1. 31 CFR 515.206 - Exempt transactions.

    Science.gov (United States)

    2010-07-01

    ... the creation of information or informational materials, and payment of royalties to a designated... data as defined in the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation... this section. Example #2: A Cuban party exports a single master copy of a Cuban motion picture to a...

  2. 44 CFR 206.375 - Loan administration.

    Science.gov (United States)

    2010-10-01

    ... management system, to account for loan funds received and disbursed and to provide an audit trail. (2) FEMA... the United States or their duly authorized representatives shall, for the purpose of audits and examination, have access to any books, documents, papers, and records that pertain to Federal...

  3. 47 CFR 76.206 - Candidate rates.

    Science.gov (United States)

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND... system practices offered to commercial advertisers that enhance the value of advertising spots must be... any discount privileges that affect the value of advertising, such as bonus spots, time-sensitive...

  4. 44 CFR 206.438 - Project management.

    Science.gov (United States)

    2010-10-01

    ... management and accountability of funds as indicated in 44 CFR part 13. The State is responsible for ensuring... in 44 CFR part 13 apply to all grant assistance provided under this subpart. FEMA may elect to... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Project management....

  5. 19 CFR 206.52 - Monitoring.

    Science.gov (United States)

    2010-04-01

    ... GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET DISRUPTION, TRADE DIVERSION, AND REVIEW OF RELIEF ACTIONS.... (c) Limited disclosure of certain confidential business information under administrative protective... available to an authorized applicant under administrative protective order all confidential...

  6. 5 CFR 430.206 - Planning performance.

    Science.gov (United States)

    2010-01-01

    ... summary levels (pattern A as specified in § 430.208(d)(1)) shall not include non-critical elements. (7) An appraisal program shall establish how many and which performance levels may be used to appraise critical and... summary level, including at least one critical element and any non-critical element(s). (5)...

  7. 9 CFR 205.206 - Farm products.

    Science.gov (United States)

    2010-01-01

    ... specify by name) Cotton Tobacco Flaxseed, peanuts, soybeans, sunflower seeds, other oil crops (system must... must specify by name) Apples, apricots, avocados, bananas, cherries, coffee, dates, figs, grapes... crops (system must specify by name) Grass seeds, legume seeds, other seed crops (system must specify...

  8. 12 CFR 206.3 - Prudential standards.

    Science.gov (United States)

    2010-01-01

    ... shall structure transactions with a correspondent or monitor exposure to a correspondent, directly or... maintain written policies and procedures to prevent excessive exposure to any individual correspondent in... operational risks, in selecting correspondents and terminating those relationships. (2) Where exposure to...

  9. 30 CFR 206.451 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... to, operations such as flotation, air, water, or heavy media separation; drying; and related handling..., storing, mixing, loading, treatment with substances including chemicals or oils, and other preparation of... the Interior. Net-back method means a method for calculating market value of coal at the lease or...

  10. 30 CFR 206.251 - Definitions.

    Science.gov (United States)

    2010-07-01

    ..., water, or heavy media separation; drying; and related handling (or combination thereof). Contract means..., treatment with substances including chemicals or oils, and other preparation of the coal to the extent that..., production, preparation, and handling of lease products. Net-back method means a method for...

  11. ACC 206 NEW Tutorial/Uoptutorial

    OpenAIRE

    Stella,, Maurizio

    2015-01-01

    For more course tutorials visit www.uoptutorial.com   ACC 205 Week 1 DQ 1 Accounting Equation  ACC 205 Week 1 DQ 2 Accounts  ACC 205 Week 1 Journal Balance Sheet Journal  ACC 205 Week 2 DQ 1 Accounting Cycle  ACC 205 Week 2 DQ 2 Bank Reconciliation  ACC 205 Week 2 Journal Income Statement Journal  ACC 205 Week 3 DQ 1 LIFO vs. FIFO  ACC 205 Week 3 DQ 2 Depreciation  ACC 205 Week 3 Journal Inventory Journal...

  12. 44 CFR 206.221 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... defined by section 1201 of the Higher Education Act of 1965. (b) Force account means an applicant's own labor forces and equipment. (c) Immediate threat means the threat of additional damage or destruction from an event which can reasonably be expected to occur within five years. (d) Improved property...

  13. 44 CFR 206.342 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... construction for a structure does not include land preparation such as clearing, grading, and placement of fill... of the facility. Permanent construction for a facility does not include land preparation such...

  14. 30 CFR 206.151 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT... operations and day-to-day management of a lease, plant, pipeline, or other facility; and (v) Other evidence... leases. BLM means the Bureau of Land Management of the Department of the Interior. Compression means...

  15. 30 CFR 206.10 - Information collection.

    Science.gov (United States)

    2010-07-01

    ... Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT... requirements contained in this part have been approved by the Office of Management and Budget (OMB) under 44 U... CFR 210.10....

  16. 28 CFR 42.206 - Compliance reviews.

    Science.gov (United States)

    2010-07-01

    ... disparity in the delivery of services to the minority and non-minority or male and female communities they... benefits; (3) The number and nature of discrimination complaints filed against a recipient with OJARS or... negotiations prior to the Director of OJARS' determination of compliance or noncompliance. (f) If, within...

  17. 12 CFR 206.4 - Credit exposure.

    Science.gov (United States)

    2010-01-01

    ...-balance sheet items that are subject to capital requirements under the capital adequacy guidelines of the... credit exposure to an individual correspondent to not more than 25 percent of the bank's total capital... cannot obtain adequate information concerning the capital ratios of the correspondent, the bank...

  18. 44 CFR 206.366 - Loan cancellation.

    Science.gov (United States)

    2010-10-01

    ... to: (i) Interest paid on money borrowed to pay amounts FEMA does not advance toward completion of... utilities for mobile homes used to meet disaster temporary housing requirements. (iii) Unreimbursed costs required for police and fire protection and other community services for mobile home parks established...

  19. 44 CFR 206.376 - Loan cancellation.

    Science.gov (United States)

    2010-10-01

    ... money borrowed to pay amounts FEMA does not advance toward completion of approved Project Applications. (ii) Unreimbursed costs to local governments for providing usable sites with utilities for mobile... and fire protection and other community services for mobile home parks established as the result of...

  20. 5 CFR 2606.206 - Fees.

    Science.gov (United States)

    2010-01-01

    ... Privacy Act fee charged in a timely fashion (i.e., within 30 days of the date of the billing). In such...-358 et seq.), including the use of consumer reporting agencies, collection agencies, and offset....

  1. 20 CFR 498.206 - Prehearing conferences.

    Science.gov (United States)

    2010-04-01

    ... definite statement; (3) Stipulations and admissions of fact as to the contents and authenticity of documents and deadlines for challenges, if any, to the authenticity of documents; (4) Whether the...

  2. 44 CFR 206.349 - Consistency determinations.

    Science.gov (United States)

    2010-10-01

    ... purpose of CBRA, as stated in section 2(b) of that statute, is to minimize the loss of human life... result from the proposed action: (1) Risks to human life; (2) Risks of damage to the facility...

  3. 27 CFR 9.206 - Shawnee Hills.

    Science.gov (United States)

    2010-04-01

    ... intersection with State Route 37; then (8) Proceed south on State Highway 37 to Saline Creek; then (9) Proceed northeasterly (downstream) along Saline Creek to its confluence with the South Fork of the Saline River, then continue easterly (downstream) along the South Fork of the Saline River to its confluence with the...

  4. 21 CFR 206.7 - Exemptions.

    Science.gov (United States)

    2010-04-01

    ... extemporaneously compounded by a licensed pharmacist, upon receipt of a valid prescription for an individual patient from a practitioner licensed by law to prescribe or administer drugs, to be used solely by...

  5. 44 CFR 206.251 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... Indian tribe or authorized tribal organization, or Alaskan Native Village or authorized native organization which has authority to adopt and enforce floodplain management regulations for the areas within... result of a major disaster. (b) Building means a walled and roofed structure, other than a gas, or...

  6. 18 CFR 157.206 - Standard conditions.

    Science.gov (United States)

    2010-04-01

    ... Discharge Elimination System Program, 40 CFR part 122 et seq.; (ii) Clean Air Act, as amended (42 U.S.C. 1801 et seq.) and air quality regulations and state implementation plans adopted pursuant to 40 CFR... update of an existing station, must not exceed a day-night level (Ldn) of 55 dBA at any...

  7. 44 CFR 206.161 - Relocation assistance.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Other Individual Assistance... eligible for any kind of replacement housing payment under the Uniform Relocation Assistance and Real... his being unable, because of a major disaster as determined by the President, to meet the...

  8. 44 CFR 206.111 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... residence is uninhabitable, inaccessible, made unavailable by the landlord (to meet their disaster housing need) or not functional as a direct result of the disaster and has no other housing available in the... subsequent to or as a result of the disaster then the determination is based upon the amount paid for...

  9. 24 CFR 206.19 - Payment options.

    Science.gov (United States)

    2010-04-01

    ... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOME EQUITY... repayment. The interest charged on the mortgage balance shall be added to the mortgage balance monthly as provided in the mortgage. Under all payment options, repayment of the mortgage balance including...

  10. 40 CFR 96.206 - Standard requirements.

    Science.gov (United States)

    2010-07-01

    ... requirements of subpart HHH of this part. (2) The emissions measurements recorded and reported in accordance with subpart HHH of this part shall be used to determine compliance by each CAIR SO2 source with the... HHH of this part. (2) A CAIR SO2 unit shall be subject to the requirements under paragraph (c)(1)...

  11. 40 CFR 97.206 - Standard requirements.

    Science.gov (United States)

    2010-07-01

    ... subpart HHH of this part. (2) The emissions measurements recorded and reported in accordance with subpart HHH of this part shall be used to determine compliance by each CAIR SO2 source with the CAIR SO2... the control period from all CAIR SO2 units at the source, as determined in accordance with subpart...

  12. Clinical distribution and drug resistance of 3 206 strains of Enterobacteriaceae bacteria%3206株肠杆菌科细菌的临床分布及耐药性分析

    Institute of Scientific and Technical Information of China (English)

    冯丽娜; 李从荣; 潘月华; 杨勇文

    2016-01-01

    目的 了解临床分离肠杆菌科细菌的临床分布及耐药性,为临床合理使用抗菌药物提供理论依据.方法 分析2014年1月至2015年6月武汉大学人民医院分离的肠杆菌科细菌分布特点及药敏结果,分离的所有肠杆菌科细菌均采用全自动细菌鉴定药敏系统BD-Phoenix-100进行鉴定.结果 共检出3 206株肠杆菌科细菌,其中主要为大肠埃希菌1 821株(56.8%)、肺炎克雷伯菌652株(20.4%)、阴沟肠杆菌201株(6.3%)、产气肠杆菌104株(3.2%),肠杆菌科细菌以尿液标本分离率最高(1 666株,52.0%),其次为痰标本(463株,14.4%)和血液标本(343株, 10.7%),科室分布以泌尿外科(599株,18.7%)和肾病内科(380株,11.9%)为主.肠杆菌科细菌敏感性最高的抗菌药物为亚胺培南和美罗培南,尤其是大肠埃希菌和肺炎克雷伯菌,耐药率均低于3.1%,阿米卡星和哌拉西林/他唑巴坦亦保持了良好的抗菌活性.结论 肠杆菌科细菌在泌尿外科和肾病内科分布比较集中,对抗菌药物呈现不同程度的耐药,碳青霉烯类抗生素亚胺培南和美罗培南仍是最敏感的抗肠杆菌科细菌药物,但已有耐药株的出现,临床应采取有效的防控措施从而减少耐药菌株的出现和播散流行.%Objective To analyze the clinical distribution and drug resistance of Enterobacteriaceae bacteria, and to provide theoretical basis for clinical rational use of antimicrobial agents. Methods The clinical distribution and drug susceptibility results of Enterobacteriaceae bacteria isolated from Renmin Hospital of Wuhan University from Janu-ary 2014 to June 2015 were analyzed. All the isolated Enterobacteriaceae bacteria were identified by automatic bacteria identification and drug susceptibility systems BD-Phoenix-100. Results A total of 3 206 strains of Enterobacteriaceae bacteria were detected, mainly including 1 821 strains (56.8%) of E. coli, 652 strains (20.4%) of Klebsiella pneumonia, 201 strains (6.3%) of

  13. SOPHIE velocimetry of Kepler transit candidates. XV. KOI-614b, KOI-206b, and KOI-680b: a massive warm Jupiter orbiting a G0 metallic dwarf and two highly inflated planets with a distant companion around evolved F-type stars

    CERN Document Server

    Almenara, J M; Bouchy, F; Havel, M; Bruno, G; Hébrard, G; Diaz, R F; Deleuil, M; Barros, S C C; Boisse, I; Bonomo, A; Montagnier, G; Santerne, A

    2015-01-01

    We report the validation and characterization of three new transiting exoplanets using SOPHIE radial velocities: KOI-614b, KOI-206b, and KOI-680b. KOI-614b has a mass of $2.86\\pm0.35~{\\rm M_{Jup}}$ and a radius of $1.13^{+0.26}_{-0.18}~{\\rm R_{Jup}}$, and it orbits a G0, metallic ([Fe/H]=$0.35\\pm0.15$) dwarf in 12.9 days. Its mass and radius are familiar and compatible with standard planetary evolution models, so it is one of the few known transiting planets in this mass range to have an orbital period over ten days. With an equilibrium temperature of $T_{eq}=1000 \\pm 45$ K, this places KOI-614b at the transition between what is usually referred to as "hot" and "warm" Jupiters. KOI-206b has a mass of $2.82\\pm 0.52~{\\rm M_{Jup}}$ and a radius of $1.45\\pm0.16~{\\rm R_{Jup}}$, and it orbits a slightly evolved F7-type star in a 5.3-day orbit. It is a massive inflated hot Jupiter that is particularly challenging for planetary models because it requires unusually large amounts of additional dissipated energy in the ...

  14. SOPHIE velocimetry of Kepler transit candidates. XV. KOI-614b, KOI-206b, and KOI-680b: a massive warm Jupiter orbiting a G0 metallic dwarf and two highly inflated planets with a distant companion around evolved F-type stars

    Science.gov (United States)

    Almenara, J. M.; Damiani, C.; Bouchy, F.; Havel, M.; Bruno, G.; Hébrard, G.; Diaz, R. F.; Deleuil, M.; Barros, S. C. C.; Boisse, I.; Bonomo, A. S.; Montagnier, G.; Santerne, A.

    2015-03-01

    We report the validation and characterization of three new transiting exoplanets using SOPHIE radial velocities: KOI-614b, KOI-206b, and KOI-680b. KOI-614b has a mass of 2.86 ± 0.35 MJup and a radius of 1.13 +0.26-0.18 RJup, and it orbits a G0, metallic ([ Fe/H ] = 0.35 ± 0.15) dwarf in 12.9 days. Its mass and radius are familiar and compatible with standard planetary evolution models, so it is one of the few known transiting planets in this mass range to have an orbital period over ten days. With an equilibrium temperature of Teq = 1000 ± 45 K, this places KOI-614b at the transition between what is usually referred to as "hot" and "warm" Jupiters. KOI-206b has a mass of 2.82 ± 0.52 MJup and a radius of 1.45 ± 0.16 RJup, and it orbits a slightly evolved F7-type star in a 5.3-day orbit. It is a massive inflated hot Jupiter that is particularly challenging for planetary models because it requires unusually large amounts of additional dissipated energy in the planet. On the other hand, KOI-680b has a much lower mass of 0.84 ± 0.15 MJup and requires less extra-dissipation to explain its uncommonly large radius of 1.99 ± 0.18 RJup. It is one of the biggest transiting planets characterized so far, and it orbits a subgiant F9-star well on its way to the red giant stage, with an orbital period of 8.6 days. With host stars of masses of 1.46 ± 0.17 M⊙ and 1.54 ± 0.09 M⊙, respectively, KOI-206b, and KOI-680b are interesting objects for theories of formation and survival of short-period planets around stars more massive than the Sun. For those two targets, we also find signs of a possible distant additional companion in the system. Based on observations made with SOPHIE on the 1.93-m telescope at the Observatoire de Haute-Provence (CNRS), France.Figures 11-14 are available in electronic form at http://www.aanda.org

  15. 49 CFR 571.206 - Standard No. 206; Door locks and door retention components.

    Science.gov (United States)

    2010-10-01

    ... components. S1. Scope and Purpose. This standard specifies requirements for vehicle door locks and door... (GVWR) of 4,536 kg or less. S3. Definitions. Auxiliary Door Latch is a latch equipped with a fully... permanently attached partition or fixed or fold-down seat back. S4. Requirements. The requirements apply...

  16. U/Pb (SHRIMP), {sup 207}Pb/{sup 206}Pb, Rb/Sr, Sm/Nd e K/Ar geochronology of granite-greenstone terrains of Gaviao Block: implications for the Proterozoic and Archean evolution of Sao Francisco Craton, Brazil; Geocronologia U/Pb (SHRIMP), {sup 207}Pb/{sup 206}Pb, Rb/Sr, Sm/Nd e K/Ar dos terrenos granito-greenstone do Bloco do Gaviao: implicacoes para a evolucao arqueana e proterozoica do craton do Sao Francisco, Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Leal, Luiz Rogerio Bastos

    1998-07-01

    The Gaviao Block (GB) in the northern portion of the Sao Francisco Craton-Northeast of Brazil, constitutes one of the oldest Archean fragments of the South American Platform Archean crust. GB underwent several events of juvenile accretion and reworking of continental crust along its evolutionary history, notably between the Archean and the Paleoproterozoic. {sup 207}Pb/{sup 206}Pb isotopic analyses were carried out in two zircons populations from strongly migmatized TTG terranes found in the proximity of Brumado: the first population (7 crystals) is taken as representative of the crystallization period of the TTG terranes at 3300 {+-} 45 Ma; the second (2 crystals) represents the age of the first even of metamorphism/migmatization at 2910 {+-} 10 Ma. {sup 207} Pb/{sup 206} Pb analyses in zircons from an outcrop of non-migmatized TTG in the area yielded a 3202 {+-} 15 Ma age (4 crystals), interpreted to be the crystallization period of the gneiss protolith. Sm/Nd analyses on the TTG rocks of the Brumado region yielded T{sub DM} model ages varying between 3.26 and 3.36 Ga and {epsilon}{sub Nd}{sup (t)} between -3.5 and +0.7. These data suggest the occurrence of juvenile accretions to the continental crust during the Archean, with differential involvement of crustal materials. The geochemical data of rare earth elements corresponding to the TTG terranes revealed moderate LRRE contents (La{sub N}=83,5), low HREE contents (La{sub N}=2,5) and a fairly fractionated pattern (La/Yb){sub N}=34, besides lack of negative Eu anomaly, showing that these rocks have similar compositions to those TTG terranes of cratonic continents, as well as some Archean rocks from CSF (e.g. Sete Voltas, Boa Vista). Finally, the youngest ages present in GB rocks (ca. 1.2-0.45 Ga) represent the role played by tectono thermal events, which produced partial or total rejuvenation of the Rb/Sr and K/Ar isotopic systems during the Espinhaco and Brasiliano cycles. In particular, K/Ar ages illustrate the

  17. Dicty_cDB: SHD206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Number of HSP's gapped (non-prelim): 0 length of query: 123 length of database: 80,480,566 effective HSP length: 17 effective... length of query: 106 effective length of database: 78,821,179 effective search space: 8355044974 effective...ve HSP length: 22 effective length of query: 101 effective length of database: 55,795,563,357 effective... search space: 5635351899057 effective search space used: 5635351899057 T: 0 A: 0 X1: 11...r of successful extensions: 0 Number of sequences better than 10.0: 0 length of query: 123 length of database: 56,950,275,839 effecti

  18. 5 CFR 551.206 - Administrative exemption criteria.

    Science.gov (United States)

    2010-01-01

    ... judgment must be more than the use of skill in applying well-established techniques, procedures, or... knowledge or skills does not preclude exemption. Such manuals and procedures provide guidance in addressing... exempt or nonexempt. For example, criminal investigators who perform work directly related to...

  19. 7 CFR 3565.206 - Ineligible uses of loan proceeds.

    Science.gov (United States)

    2010-01-01

    ... not affixed to the real estate, such as special portable equipment, furnishings, kitchen ware, dining... uses of loan proceeds. Loan proceeds must not be used for the following: (a) Specialized equipment...

  20. 47 CFR 20.6 - CMRS spectrum aggregation limit.

    Science.gov (United States)

    2010-10-01

    ... any right to determine how the stock will be voted. Holdings by investment companies will be... telephone company, or a business owned by minorities and/or women, as these terms are defined in § 1.2110 of...) regulated as CMRS (see 47 CFR 20.9) shall have an attributable interest in a total of more than 55 MHz...

  1. 24 CFR 206.47 - Property standards; repair work.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... back a portion of the contract price attributable to the work done before each interim release of funds, and the total of the hold backs will be released after the final inspection and approval of...

  2. 40 CFR 180.206 - Phorate; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... following food commodities: Commodity Parts per million Bean, dry, seed 0.05 Bean, succulent 0.05 Beet, sugar, roots 0.3 Beet, sugar, tops 3.0 Coffee, green bean 1 0.02 Corn, field, forage 0.5 Corn, field... the growing crop, coffee. (b) Section 18 emergency exemptions. (c) Tolerances with...

  3. Dicty_cDB: VFM206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available nfkmmvf hticyglmlnnvmdvgvi*vttqhlfkkplklpkilvlmlvftvqlvngvkl*vi*vv*v ltygmltmiiih...hsliqafmnlvvglhql*nntlvmemsvvlali*islvlehvqhqlvq vqahhqvhhqvhhqvhhqvqvhhqvqvhhrvhhqvqdqahhhqdq Frame B: flil

  4. 48 CFR 49.206-1 - Submission of settlement proposals.

    Science.gov (United States)

    2010-10-01

    ... accounting data. Actual, standard (appropriately adjusted), or average costs may be used in preparing settlement proposals if they are determined under generally recognized accounting principles consistently... not be required to maintain unduly elaborate cost accounting systems merely because their...

  5. 30 CFR 206.461 - Determination of transportation allowances.

    Science.gov (United States)

    2010-07-01

    ... market the production for the mutual benefit of the lessee and the lessor, then MMS shall require that...-per-unit basis, the lessee shall convert whatever consideration is paid to a dollar value equivalent..., overhead, and either depreciation and a return on undepreciated capital investment in accordance...

  6. 5 CFR 870.206 - Accidental death and dismemberment.

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES' GROUP LIFE INSURANCE PROGRAM Types and Amount of Insurance § 870..., accidental death benefits are equal to the amount of Option A. (c)(1) Under Basic insurance, accidental... automatic part of Basic and Option A insurance for employees. (2) There is no accidental death...

  7. 31 CFR 206.6 - Cash management planning and review.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Cash management planning and review... planning and review. (a) An agency shall periodically perform cash management reviews to identify areas...) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE MANAGEMENT OF FEDERAL...

  8. 30 CFR 206.262 - Determination of transportation allowances.

    Science.gov (United States)

    2010-07-01

    ... either a straight-line depreciation method based on the life of equipment or on the life of the reserves... claim a transportation allowance by reporting it as a separate line entry on the Form MMS-4430. (2) In... reporting it as a separate line entry on the Form MMS-4430. When necessary or appropriate, MMS may direct...

  9. 30 CFR 206.259 - Determination of washing allowances.

    Science.gov (United States)

    2010-07-01

    ... either a straight-line depreciation method based on the life of equipment or on the life of the reserves... as a separate line entry on the Form MMS-4430. (2) In conducting reviews and audits, MMS will examine... reporting it as a separate line entry on the Form MMS-4430. When necessary or appropriate, MMS may direct...

  10. 30 CFR 206.57 - Determination of transportation allowances.

    Science.gov (United States)

    2010-07-01

    ... lessee may elect to use either a straight-line depreciation method based on the life of equipment or on... cost allocation method on the basis of the values of the products transported. MMS shall approve the method unless it determines that it is not consistent with the purposes of the regulations in this...

  11. 30 CFR 206.458 - Determination of washing allowances.

    Science.gov (United States)

    2010-07-01

    ... may elect to use either a straight-line depreciation method based on the life of equipment or on the... depreciation and a return on undepreciated capital investment in accordance with paragraph (b)(2)(iv)(A) of... section. After a lessee has elected to use either method for a wash plant, the lessee may not later...

  12. 30 CFR 206.159 - Determination of processing allowances.

    Science.gov (United States)

    2010-07-01

    ... depreciation, the lessee may elect to use either a straight-line depreciation method based on the life of..., including operating and maintenance expenses, overhead, and either depreciation and a return on..., including royalties, are not allowable expenses. (iv) A lessee may use either depreciation or a return...

  13. 44 CFR 206.42 - Responsibilities of coordinating officers.

    Science.gov (United States)

    2010-10-01

    ... as necessary to coordinate and monitor assistance programs, disseminate information, accept applications, and counsel individuals, families and businesses concerning available assistance; (3) Coordinate... SCO coordinates State and local disaster assistance efforts with those of the Federal...

  14. 12 CFR 206.5 - Capital levels of correspondents.

    Science.gov (United States)

    2010-01-01

    ... standards. See, e.g. 12 CFR part 208, subpart D. (1) A total risk-based capital ratio, as defined in... capital to average total consolidated assets, as calculated in accordance with the capital adequacy... capital adequacy guidelines of the correspondent's primary federal supervisor. (2) For a...

  15. 44 CFR 206.370 - Purpose and scope.

    Science.gov (United States)

    2010-10-01

    ..., and the Emergency Supplemental Appropriations Act for Defense, the Global War on Terror, and Hurricane... Emergency Supplemental Appropriations Act for Defense, the Global War on Terror, and Hurricane...

  16. Dicty_cDB: VSD206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available mino Acid sequence kqdqldllaqvlgegedsgkneileedfdditrgakkskssaptvsrttggstralsggn dmnymeyqapaiyksiptqhalfkqrak...ikllqfikvfqlnmhylnnvlkinnkk*ikk*tkk Frame C: kqdqldllaqvlgegedsgkneileedfdditrgak

  17. 5 CFR 575.206 - Authorizing a relocation incentive.

    Science.gov (United States)

    2010-01-01

    ... use of a direct-hire authority applicable to the position (or group of positions) under 5 CFR part 337... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Authorizing a relocation incentive. 575... RECRUITMENT, RELOCATION, AND RETENTION INCENTIVES; SUPERVISORY DIFFERENTIALS; AND EXTENDED...

  18. 19 CFR 206.14 - Contents of petition.

    Science.gov (United States)

    2010-04-01

    ... operations at a reasonable level of profit; and (iii) Significant unemployment or underemployment within the... imports accounted for by imports from each NAFTA country (Canada and Mexico), and petitioner's view on...

  19. Dicty_cDB: SHH206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available mino Acid sequence hci*kiilk*k*k*k*kk*kiypclaiiiylynikinkk*k*INNNNNYNNSNNKMYNFF DRIKAPLSEYKRYAANHKKDDDFTDIED...lated Amino Acid sequence (All Frames) Frame A: hci*kiilk*k*k*k*kk*kiypclaiiiylynikinkk*k*INNNNNYNNSNNKMYNFF

  20. Dicty_cDB: VFG206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 2) mRNA, complete cds. 387 e-104 1 AC098048 |AC098048.6 Rattus norvegicus clone CH230-115I10, WORKING DRAFT ...SEQUENCE, 3 unordered pieces. 44 0.67 1 AC121005 |AC121005.4 Rattus norvegicus clone CH230-322A11, WORKING D...RAFT SEQUENCE, 1 ordered piece. 36 2.6 2 AC040900 |AC040900.3 Homo sapiens chromosome 1 clone RP11-162H11 map 1, WORK...sapiens chromosome 15 clone RP11-438C24 map 15, WORKING DRAFT SEQUENCE, 16 unorde... 42 2.7 1 AC142424 |AC142424.2 Rattus norvegicus clone CH230-408K24, WORKING DRAFT SEQUENCE, 39 unordered pi

  1. 19 CFR 10.206 - Value content requirement.

    Science.gov (United States)

    2010-04-01

    ...)(ii), no material shall be considered to be substantially transformed into a new or different article... appropriate port director, the material shall not be considered to have been grown, produced, or manufactured... manufactured in a beneficiary country as defined in § 10.202(a) exclusively from materials which are wholly...

  2. 21 CFR 206.10 - Code imprint required.

    Science.gov (United States)

    2010-04-01

    ... identification than a symbol or logo by itself. Homeopathic drug products are required only to bear an imprint that identifies the manufacturer and their homeopathic nature. (b) A holder of an approved...

  3. 24 CFR 570.206 - Program administrative costs.

    Science.gov (United States)

    2010-04-01

    ... related to the planning and execution of community development activities assisted in whole or in part.... (2) Travel costs incurred for official business in carrying out the program; (3) Administrative... participating in the planning, implementation, or assessment of activities being assisted with CDBG funds....

  4. 24 CFR 1003.206 - Program administration costs.

    Science.gov (United States)

    2010-04-01

    ... reasonable administrative costs and carrying charges related to the planning and execution of community... official business in carrying out the program; (3) Administrative services performed under third party... organizations participating in the planning, implementation, or assessment of activities being assisted...

  5. 33 CFR 160.206 - Information required in an NOA.

    Science.gov (United States)

    2010-07-01

    ... Form 1302) as described in 19 CFR 4.7 X X X (9) International Ship and Port Facility Code (ISPS) Notice... description of cargo, other than CDC, onboard the vessel (e.g.: grain, container, oil, etc.); X X X (ii) Name...) Amount of each certain dangerous cargo carried X X (4) Information for each Crewmember Onboard: (i)...

  6. 48 CFR 15.206 - Amending the solicitation.

    Science.gov (United States)

    2010-10-01

    ... the contract file and formalize the notice with an amendment (see subpart 4.5, Electronic Commerce in... (and electronic or facsimile address, if appropriate). (7) Revision to solicitation closing date,...

  7. 44 CFR 206.435 - Project identification and selection criteria.

    Science.gov (United States)

    2010-10-01

    ... potential loss of life, loss of essential services, damage to critical facilities, or economic hardship on the community; (3) Measures that have the greatest potential impact on reducing future disaster...

  8. 44 CFR 206.33 - Preliminary damage assessment.

    Science.gov (United States)

    2010-10-01

    ... requesting this support. (b) Damage assessment teams. Damage assessment teams will be composed of at least... possible. Other State and Federal agencies, and voluntary relief organizations may also be asked to... official will brief team members on damage criteria, the kind of information to be collected for...

  9. 30 CFR 75.206 - Conventional roof support.

    Science.gov (United States)

    2010-07-01

    ...-sectional area of wooden posts shall be as follows: Post length (in inches) Diameter of round posts (in... 204 to 228 11 95 Over 228 12 113 (2) Wooden materials used for support shall have the following dimensions: (i) Cap blocks and footings shall have flat sides and be at least 2 inches thick, 4 inches...

  10. 44 CFR 206.171 - Crisis counseling assistance and training.

    Science.gov (United States)

    2010-10-01

    ... appeals procedures 42 CFR part 50, subpart D—PHS grant appeals procedures 45 CFR part 74—Administration of... health network, the State cannot carry out the crisis counseling program, he/she may identify a public or.... If, during the course of the assessment, the State determines that immediate mental health...

  11. 44 CFR 206.44 - FEMA-State Agreements.

    Science.gov (United States)

    2010-10-01

    ... Agreement imposes binding obligations on FEMA, States, their local governments, and private nonprofit... Households Program. (b) Terms and conditions. This Agreement describes the incident and the incident...

  12. 42 CFR 457.206 - Administrative appeals under CHIP.

    Science.gov (United States)

    2010-10-01

    ... provisions of 42 CFR part 430, subpart D of this chapter. (b) FFP in State CHIP expenditures. Disallowances... the Departmental Appeals Board (the Board) in accordance with procedures set forth in 45 CFR part 16. (c) Discretionary grants disputes. Determinations listed in 45 CFR part 16, appendix A, pertaining...

  13. 19 CFR 206.42 - Who may file a petition.

    Science.gov (United States)

    2010-04-01

    ... petition under section 406(a) of the Trade Act may be filed by an entity, including a trade association... threat thereof, to such domestic industry. (b) A petition under section 421(b) or (o) of the Trade Act may be filed by an entity, including a trade association, firm, certified or recognized union,...

  14. 19 CFR 206.62 - Who may file a petition.

    Science.gov (United States)

    2010-04-01

    ... Who may file a petition. A petition for an investigation under section 422(b) of the Trade Act may be filed by an entity, including a trade association, firm, certified or recognized union, or group of... Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS...

  15. 19 CFR 206.15 - Institution of investigation.

    Science.gov (United States)

    2010-04-01

    ... report to the President of the results of such previous investigation. (2) Articles subject to prior action. No new investigation will be made under section 202 of the Trade Act with respect to an article...) Articles subject to the Textiles Agreement. No investigation will be made under section 202 of the...

  16. 30 CFR 206.157 - Determination of transportation allowances.

    Science.gov (United States)

    2010-07-01

    ... transportation contracts in the most recent preceding production month in which the tariff remains in effect and... 50 percent of the base price of the product without MMS approval. (b) Non-arm's-length or no contract. (1) If a lessee has a non-arm's-length transportation contract or has no contract, including...

  17. 7 CFR 20.6 - Submission of reports.

    Science.gov (United States)

    2010-01-01

    ... same kind of commodity made from foreign sellers during the week. (iv) Quantity of export sales... from foreign sellers, show separately from export sales all items of this paragraph (d). (e) Reporting... from foreign sellers. (2) A reporting exporter may discontinue reporting for a commodity only...

  18. 44 CFR 206.118 - Disposal of housing units.

    Science.gov (United States)

    2010-10-01

    ... providing temporary housing to disaster victims in major disasters and emergencies. As a condition of the... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Disposal of housing units..., DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Federal Assistance...

  19. 44 CFR 206.114 - Criteria for continued assistance.

    Science.gov (United States)

    2010-10-01

    ... a permanent housing plan through no fault of their own. (4) FEMA may certify pre-disaster owners for..., DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Federal Assistance to... assistance under this subpart to obtain and occupy permanent housing at the earliest possible time. FEMA...

  20. 32 CFR 206.3 - Overall program emphasis.

    Science.gov (United States)

    2010-07-01

    ... opportunities exist. (3) Enhance meaningful opportunities for foreign language and foreign culture acquisition... might address the following issues: (1) Enhancing foreign language skill acquisition through innovative...-represented by U.S. students, and (ii) Development of meaningful competencies in foreign languages...

  1. Dicty_cDB: AFI206 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available EST320223 tomato radicle, 5 d post-imbibition, Cornell University Lycopersicon esculentum cDNA clone cLEZ19K... AI782264 |AI782264.1 EST263143 tomato susceptible, Cornell Lycopersicon esculentum cDNA clone cLES18L5, mRN

  2. 44 CFR 206.35 - Requests for emergency declarations.

    Science.gov (United States)

    2010-10-01

    ..., which would not qualify under the definition of a major disaster, the Governor of a State, or the Acting... lives and to protect property, public health and safety, or to lessen or avert the threat of a...

  3. 76 FR 12274 - Special Conditions: Bell Helicopter Textron Canada Limited Model 206B and 206L Series Helicopters...

    Science.gov (United States)

    2011-03-07

    ... Society of Automotive Engineers (SAE) document Aerospace Recommended Practice (ARP) 4761 (Guidelines and... Rotorcraft) and Society of Automotive Engineers (SAE) document Aerospace Recommended Practice (ARP) 4761... document between 8:30 a.m. and 4 p.m., Monday through Friday, except Federal holidays. We will consider...

  4. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE,CERN

    OpenAIRE

    Rothe, Sebastian

    2012-01-01

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spec...

  5. 7 CFR 205.206 - Crop pest, weed, and disease management practice standard.

    Science.gov (United States)

    2010-01-01

    ...) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling... substance included on the National List of synthetic substances allowed for use in organic crop...

  6. 20 CFR 802.206 - Effect of motion for reconsideration on time for appeal.

    Science.gov (United States)

    2010-04-01

    ... appeal. (b)(1) In a case involving a claim filed under the Longshore and Harbor Workers' Compensation Act... title IV of the Federal Mine Safety and Health Act, as amended (see § 802.101(b)(6)), a timely motion... subsequent to the filing of the timely motion for reconsideration, shall be dismissed without prejudice...

  7. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (206-0613-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  8. The environment of south-central Tunisia as observed on Landsat scene 206/036

    Science.gov (United States)

    Grolier, M.J.; Schultejann, P.A.

    1982-01-01

    One Landsat image in south-central Tunisia was analyzed to demonstrate the application of remote-sensing technology to regional development. A preliminary analysis included I) major landscape features; 2) gypsum-encrusted soils; and 3) phosphate-bearing beds exposed in the Gafsa mining district. The products specifically used for this report include: 1) A false-color composite (FCC), which had been linearly stretched to enhance contrast, and to which a modulation transfer function correction (a high-pass filter 3 pixels by 3 pixels wide) had been applied to enhance fine topographic relief. 2) A sinusoidally stretched false-color composite, on which mappable gypsum-encrusted soils and saline soils are detectable in greater detail than on the existing soil map of Tunisia at 1:500,000 scale. 3) A sinusoidally stretched band-ratio false-color composite, from which a thematic map of most phosphate-bearing beds in the Gafsa mining district was prepared. Recommendations for future Landsat image interpretation in Tunisia are offered.

  9. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (206-0613-272217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  10. 31 CFR 500.206 - Exemption of information and informational materials.

    Science.gov (United States)

    2010-07-01

    ... market, produce or co-produce, create or assist in the creation of information or informational materials... Regulations, 15 CFR parts 768-799, or to the exportation of goods for use in the transmission of any data. The... permissible transactions under this section. Example #2: A Vietnamese party exports a single master copy of...

  11. 44 CFR 206.12 - Use and coordination of relief organizations.

    Science.gov (United States)

    2010-10-01

    ... MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE General... facilities of the American National Red Cross, the Salvation Army, the Mennonite Disaster Service, and other voluntary organizations in the distribution of medicine, food, supplies, or other items, and in...

  12. 48 CFR 206.302-5 - Authorized or required by statute.

    Science.gov (United States)

    2010-10-01

    .... 2424, soft drinks manufactured in the United States are brand name carbonated sodas, manufactured in... universities for the performance of research and development, or for the construction of any research or...

  13. 42 CFR 495.206 - Timeframe for payment to qualifying MA organizations.

    Science.gov (United States)

    2010-10-01

    ... organizations for qualifying MA-affiliated eligible hospitals under common corporate governance are made under... common corporate governance under the Medicare FFS EHR incentive program, payment is made under the...

  14. 19 CFR 206.8 - Service, filing, and certification of documents.

    Science.gov (United States)

    2010-04-01

    ... INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET DISRUPTION, TRADE... made by facsimile transmission. A copy of the petition including all confidential business information... each document, except transcripts of hearings, confidential business information,...

  15. 19 CFR 206.3 - Institution of investigations; publication of notice; and availability for public inspection.

    Science.gov (United States)

    2010-04-01

    ... INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL... Commission motion available for public inspection (with the exception of confidential business information)....

  16. 19 CFR 206.54 - Investigations with respect to extension of action.

    Science.gov (United States)

    2010-04-01

    ... INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL AND BILATERAL SAFEGUARD ACTIONS, MARKET DISRUPTION, TRADE...) Limited disclosure of certain confidential business information under administrative protective order... available to an authorized applicant under administrative protective order all confidential...

  17. 30 CFR 206.359 - How do I determine byproduct transportation allowances?

    Science.gov (United States)

    2010-07-01

    ... the production for the mutual benefit of the lessee and the lessor, MMS will require you to determine... transportation under an arm's-length contract are not established on a dollars-per-unit basis, you must convert... under paragraph (f) of this section; and either (3) Depreciation under paragraphs (g) and (h) of...

  18. 78 FR 20167 - 33rd Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data Link...

    Science.gov (United States)

    2013-04-03

    ... be held at NCAR, 3080 Center Green Drive, Boulder, CO 80301. FOR FURTHER INFORMATION CONTACT: The... necessary daily EDR Turbulence Standards Project Briefing from FAA SE2020 Team SG6 WG1 Architecture and MASPS presentations SG3 AIS and MET Services Delivery Architecture Recommendations Document Review...

  19. 30 CFR 206.178 - How do I determine a transportation allowance?

    Science.gov (United States)

    2010-07-01

    ... either a straight-line depreciation method based on the life of equipment or on the life of the reserves...)(i) of this section, you may propose to MMS a cost allocation method based on the values of the products transported. MMS will approve the method if we determine that it meets one of the two...

  20. 30 CFR 206.353 - How do I determine transmission deductions?

    Science.gov (United States)

    2010-07-01

    ... use a straight-line depreciation method based on the life of the geothermal project, usually the term... in the transmission line. After a lessee has elected to use either method, the lessee may not later... of either or both of two components: (i) Transmission line costs as determined under paragraph (b)...

  1. 30 CFR 206.180 - How do I determine an actual processing allowance?

    Science.gov (United States)

    2010-07-01

    ... depreciation, you may elect to use either a straight-line depreciation method based on the life of equipment or... maintenance expenses, overhead, and either depreciation and a return on undepreciated capital investment (in... allowable expenses. (iv) You may use either depreciation with a return on undepreciable capital...

  2. 30 CFR 206.354 - How do I determine generating deductions?

    Science.gov (United States)

    2010-07-01

    ... other alternative without MMS approval. (h)(1) To compute depreciation, you must use a straight-line depreciation method based on the life of the geothermal project, usually the term of the electricity sales...) Depreciation under paragraphs (g) and (h) of this section and a return on undepreciated capital...

  3. 7 CFR 62.206 - Access to program documents and activities.

    Science.gov (United States)

    2010-01-01

    ... AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT... business hours or during periods of production, for the purpose of evaluating products or processes....

  4. 75 FR 71154 - Receipt of Request for Action Under 10 CFR 2.206

    Science.gov (United States)

    2010-11-22

    ... FirstEnergy relating to inadequate financial assurance provided by the licensee for TMI-2's nuclear decommissioning fund prior to the consummation of FirstEnergy's proposed merger with Allegheny Energy. As the basis for this request, the petitioner states that the current radiological decommissioning...

  5. 24 CFR 206.101 - Sale, assignment and pledge of insured mortgages.

    Science.gov (United States)

    2010-04-01

    ... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOME EQUITY CONVERSION MORTGAGE INSURANCE Contract Rights...

  6. 24 CFR 960.206 - Waiting list: Local preferences in admission to public housing program.

    Science.gov (United States)

    2010-04-01

    ... victims of domestic violence. (5) Preference for single persons who are elderly, displaced, homeless or a... or older, displaced, homeless, or persons with disabilities over other single persons. (c) Selection... persons. A single person who is not an elderly or displaced person, or a person with disabilities, or...

  7. 76 FR 72240 - Twenty-Seventh Meeting: RTCA Special Committee 206: Aeronautical Information and Meteorological...

    Science.gov (United States)

    2011-11-22

    .../Roadmap--SG3 Chairmen Discuss Proposed TOR Changes Final Review and Comment (FRAC): Operational Services... dates Approve proposed TOR changes Decision to release the ConUse document for FRAC process Decision...

  8. 76 FR 54526 - 26th Meeting: RTCA Special Committee 206: Aeronautical Information and Meteorological Data Link

    Science.gov (United States)

    2011-09-01

    ... Deliverables in TOR and potential changes. Discuss the certification and liability issues surrounding the use... Dates. Discuss Status of Deliverables in TOR and potential changes. Decision to release DO-267A...

  9. 77 FR 3030 - Twenty-Eighth Meeting: RTCA Special Committee 206: Aeronautical Information and Meteorological...

    Science.gov (United States)

    2012-01-20

    ... proposed TOR changes ConUse Review February 7, 2012 ConUse Review February 8, 2012 SG1, SG2, and SG3... presentation selection process Approve advisory and normal definitions Approve proposed TOR changes and new...

  10. 77 FR 20688 - 29th Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data Link...

    Science.gov (United States)

    2012-04-05

    ... Status. Discuss previously proposed TOR changes and DO-252 Revision. Discuss TOR changes for the June PMC... release to the PMC. Agree upon TOR changes for June PMC meeting. Other business. Adjourn--1...

  11. CROS, Edmond, La sociocritique, Paris, L’Harmattan, 2003, 206 p.

    Directory of Open Access Journals (Sweden)

    2005-07-01

    Full Text Available Née dans les années soixante du croisement de la psychanalyse et du matérialisme dialectique, la sociocritique s’est donné pour objectif un renouvellement de l’approche sociologique de la littérature qui intègre les avancées du structuralisme, de la sémiologie et de la linguistique. Edmond Cros, co-fondateur de la discipline en France avec Claude Duchet, propose un ouvrage de synthèse sur la question. Ce livre est le produit d’une pratique de plus de trente années, tant comme chercheur dans l...

  12. 78 FR 51808 - 34th Meeting: RTCA Special Committee 206, Aeronautical Information and Meteorological Data Link...

    Science.gov (United States)

    2013-08-21

    ... Recommendations document to enter FRAC Action item review Future meeting plans and dates Industry Coordination: Report on SAE G-10A ARP 6467 SFO Other business Adjourn Attendance is open to the interested public...

  13. 30 CFR 206.351 - What definitions apply to this subpart?

    Science.gov (United States)

    2010-07-01

    ... required to produce the resource used in production of electricity for sale or to convert geothermal energy... geothermal resources for commercial, residential, agricultural, public facilities, or other energy needs... that uses the heat or other energy of the geothermal resource for direct use purposes....

  14. Navy's land and water use assessment : Section 206©- Public Law 101-618

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This note is about an Environmental Assessment in which the Naval Air Station in Fallon, NV proposes an agricultural leasing program for Navy lands to reduce soil...

  15. SU-E-J-206: Adaptive Radiotherapy for Gynecological Malignancies with MRIGuided Cobolt-60 Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Lamb, J; Kamrava, M; Agazaryan, N; Cao, M; Low, D; Thomas, D; Yang, Y [UCLA School of Medicine, Los Angeles, CA (United States)

    2015-06-15

    Purpose: Even in the IMRT era, bowel toxicity and bone marrow irradiation remain concerns with pelvic irradiation. We examine the potential gain from an adaptive radiotherapy workflow for post-operative gynecological patients treated to pelvic targets including lymph nodes using MRI-guided Co-60 radiation therapy. Methods: An adaptive workflow was developed with the intent of minimizing time overhead of adaptive planning. A pilot study was performed using retrospectively analyzed images from one patient’s treatment. The patient’s treated plan was created using conventional PTV margins. Adaptive treatment was simulated on the patient’s first three fractions. The daily PTV was created by removing non-target tissue, including bone, muscle and bowel, from the initial PTV based on the daily MRI. The number of beams, beam angles, and optimization parameters were kept constant, and the plan was re-optimized. Normal tissue contours were not adjusted for the re-optimization, but were adjusted for evaluation of plan quality. Plan quality was evaluated based on PTV coverage and normal tissue DVH points per treatment protocol. Bowel was contoured as the entire bowel bag per protocol at our institution. Pelvic bone marrow was contoured per RTOG protocol 1203. Results: For the clinically treated plan, the volume of bowel receiving 45 Gy was 380 cc, 53% of the rectum received 30 Gy, 35% of the bladder received 45 Gy, and 28% of the pelvic bone marrow received 40 Gy. For the adaptive plans, the volume of bowel receiving 45 Gy was 175–201 cc, 55–62% of the rectum received 30 Gy, 21– 27% of the bladder received 45 Gy, and 13–17% of the pelvic bone marrow received 40 Gy. Conclusion: Adaptive planning led to a large reduction of bowel and bone marrow dose in this pilot study. Further study of on-line adaptive techniques for the radiotherapy of pelvic lymph nodes is warranted. Dr. Low is a member of the scientific advisory board of ViewRay, Inc.

  16. 12 CFR 303.206 - Application for payment of principal or interest on subordinated debt.

    Science.gov (United States)

    2010-01-01

    ... explanation of action taken under section 38(h)(3)(A)(ii) of the FDI Act (action other than receivership or... the FDI Act (12 U.S.C. 1831o). Existing approvals pursuant to requests filed under section 18(i)(1) of the FDI Act (12 U.S.C. 1828(i)(1)) (capital stock reductions or retirements) shall not be deemed to...

  17. 31 CFR 598.206 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ..., such as currency, bank deposits, or liquidated financial obligations, subject to § 598.202 shall hold... federally-insured U.S. bank, thrift institution, or credit union, provided the funds are earning interest at... holder of blocked tangible property, such as chattels or real estate, or of other blocked property,...

  18. 29 CFR 779.206 - What are “related activities.”

    Science.gov (United States)

    2010-07-01

    ... AS APPLIED TO RETAILERS OF GOODS OR SERVICES Employment to Which the Act May Apply; Enterprise... retail or service stores in a chain, or departments of an establishment operated through leasing... common business purpose of the enterprise. The Senate Report on the 1966 amendments makes it plain...

  19. PS2-06: Feasibility of Determining Medication Adherence from Electronic Health Record Medication Orders

    OpenAIRE

    Carroll, Nikki; Luckett, Capp; Ellis, Jennifer; Raebel, Marsha

    2010-01-01

    Background and Aims: Medication adherence is essential to optimizing outcomes for many chronic diseases. Typically, calculation of adherence is based on dispensings identified from pharmacy claims databases. However, this procedure excludes prescription orders that are never dispensed and potentially results in biased adherence estimates. To explore extracting newly-ordered medications from the Electronic Health Record (EHR), we conducted a project to:

  20. 17 CFR 275.206(3)-2 - Agency cross transactions for advisory clients.

    Science.gov (United States)

    2010-04-01

    ... advisory client, provided that such written consent is obtained after full written disclosure that with... (iv) the source and amount of any other remuneration received or to be received by the investment... may state whether any other remuneration has been or will be received and that the source and...

  1. 5 CFR 531.206 - Order of processing simultaneous pay actions.

    Science.gov (United States)

    2010-01-01

    ... or adjustment of a special rate schedule under 5 CFR part 530, subpart C, or similar legal authority (e.g., 38 U.S.C. 7455); and an adjustment of a retained rate under 5 CFR 359.705(d)(1) and 536.305(a... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Order of processing simultaneous...

  2. 46 CFR 197.206 - Substitutes for required equipment, materials, apparatus, arrangements, procedures, or tests.

    Science.gov (United States)

    2010-10-01

    ... particular equipment, material, apparatus, arrangement, procedure, or test is unreasonable or impracticable, the Commandant may permit the use of alternate equipment, material, apparatus, arrangement, procedure, or test to such an extent and upon such condition as will insure, to his satisfaction, a degree...

  3. 32 CFR 206.1 - Major characteristics of the NSEP institutional grants program.

    Science.gov (United States)

    2010-07-01

    ... taught languages and cultures and enable them to become integrally involved in global issues. (2) To... professionals with more than the traditional knowledge of language and culture who can use this ability to help... institutional capacity and increase the number of faculty who can educate U.S. citizens toward achieving...

  4. 30 CFR 206.104 - What publications are acceptable to MMS?

    Science.gov (United States)

    2010-07-01

    ... buyers and sellers frequently use; (2) Publications frequently mentioned in purchase or sales contracts... daily surveys of buyers and sellers of crude oil, and, for ANS spot prices, buyers and sellers of...

  5. 5 CFR 339.206 - Disqualification on the basis of medical history.

    Science.gov (United States)

    2010-01-01

    ... Disqualification on the basis of medical history. A candidate may not be disqualified for any position solely on the basis of medical history. For positions with medical standards or physical requirements, or positions subject to medical evaluation programs, a history of a particular medical problem may result...

  6. 34 CFR 206.5 - What definitions apply to these programs?

    Science.gov (United States)

    2010-07-01

    ... part are defined in 34 CFR part 74 (Administration of Grants): Budget Equipment Grant Grantee Supplies... 201.3 (Chapter 1—Migrant Education Program) and 20 CFR 633.104 (Employment and Training Administration... ENGAGED IN MIGRANT AND OTHER SEASONAL FARMWORK-HIGH SCHOOL EQUIVALENCY PROGRAM AND COLLEGE...

  7. 46 CFR 117.206 - Survival craft-vessels operating on Great Lakes routes.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Survival craft-vessels operating on Great Lakes routes...—vessels operating on Great Lakes routes. (a) Except as allowed by paragraph (b) of this section, each vessel certificated to operate on a Great Lakes route must be provided with the survival craft...

  8. 30 CFR 206.257 - Valuation standards for ad valorem leases.

    Science.gov (United States)

    2010-07-01

    ... CFR 218.202. If the lessee is entitled to a credit, MMS will provide instructions for the taking of... Information Act regulation of the Department of the Interior, 43 CFR part 2. ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Valuation standards for ad valorem leases....

  9. 30 CFR 206.455 - Valuation standards for cents-per-ton leases.

    Science.gov (United States)

    2010-07-01

    ... is avoidably lost as determined by BLM pursuant to 43 CFR part 3400. (c) For leases subject to this... other processing or preparation of the coal. (d) When a coal lease is readjusted pursuant to 43 CFR part... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Valuation standards for cents-per-ton...

  10. 30 CFR 206.256 - Valuation standards for cents-per-ton leases.

    Science.gov (United States)

    2010-07-01

    ... to 43 CFR part 3400 and the royalty valuation method changes from a cents-per-ton basis to an ad..., including coal which is avoidably lost as determine by BLM pursuant to 43 CFR part 3400. (c) For leases... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Valuation standards for cents-per-ton...

  11. 30 CFR 206.456 - Valuation standards for ad valorem leases.

    Science.gov (United States)

    2010-07-01

    ... shall also be liable for interest computed pursuant to 30 CFR 218.202. If the lessee is entitled to a... regulation of the Department of the Interior, 43 CFR part 2. Nothing in this section is intended to limit or... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Valuation standards for ad valorem leases....

  12. 27 CFR 70.206 - Discharge of liens; redemption by United States.

    Science.gov (United States)

    2010-04-01

    ... this section, shall constitute prima facie evidence of the regularity of the redemption. When a... include the amount of the obligation secured by such lien to the extent legally satisfied by reason of the... obligation secured by such lien to the extent legally satisfied by reason of the sale and (B) Any...

  13. 5 CFR 536.206 - Determining an employee's rate of basic pay under grade retention.

    Science.gov (United States)

    2010-01-01

    ... entitled to a saved rate under 5 CFR 359.705, the agency must determine the employee's payable rate of... prescribed in the rules governing the covered pay system of the employee's position of record (e.g., 5 CFR... employee's rate of basic pay under grade retention. (a) General. (1) When an employee becomes entitled...

  14. 42 CFR 3.206 - Confidentiality of patient safety work product.

    Science.gov (United States)

    2010-10-01

    ... following direct identifiers of any providers and of affiliated organizations, corporate parents... prints; and (13) Full face photographic images and any comparable images; and (B) With respect to any... at 45 CFR 164.514(e)(2) have been removed. (5) Disclosure of nonidentifiable patient safety...

  15. Compound list: simvastatin [Open TG-GATEs

    Lifescience Database Archive (English)

    Full Text Available simvastatin SST 00117 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/simv...astatin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/simv...astatin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/simv...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/simvastatin.Rat.in_vivo.Liver.Repeat.zip ...

  16. Oahu Hyperspectral Imagery 2000 (206-0613-272217) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  17. Return on Endowment Funds Dropped an Average of 2.2 Pct. for 206 Colleges Last Year.

    Science.gov (United States)

    Evangelauf, Jean

    1985-01-01

    The trends in institutional investment of endowment funds for the year ending June 30, 1984, are analyzed, including average returns, extremes, total endowment values, and the distribution of investments. The data are from an annual national comparative performance survey. (MSE)

  18. Feather lead concentrations and207Pb/206Pb ratios reveal lead exposure history of California condors (Gymnogyps californianus)

    Science.gov (United States)

    Finkelstein, M.E.; George, D.; Scherbinski, S.; Gwiazda, R.; Johnson, M.; Burnett, J.; Brandt, J.; Lawrey, S.; Pessier, Allan P.; Clark, M.; Wynne, J.; Grantham, And J.; Smith, D.R.

    2010-01-01

    Lead poisoning is a primary factor impeding the survival and recovery of the critically endangered California Condor (Gymnogyps californianus). However, the frequency and magnitude of lead exposure in condors is not well-known in part because most blood lead monitoring occurs biannually, and biannual blood samples capture only ???10% of a bird's annual exposure history. We investigated the use of growing feathers from free-flying condors in California to establish a bird's lead exposure history. We show that lead concentration and stable lead isotopic composition analyses of sequential feather sections and concurrently collected blood samples provided a comprehensive history of lead exposure over the 2-4 month period of feather growth. Feather analyses identified exposure events not evident from blood monitoring efforts, and by fitting an empirically derived timeline to actively growing feathers, we were able to estimate the time frame for specific lead exposure events. Our results demonstrate the utility of using sequentially sampled feathers to reconstruct lead exposure history. Since exposure risk in individuals is one determinant ?? 2010 American Chemical Society.

  19. Shelf edge exchange processes-II SEEP2-06, R/V Endeavor cruise 186. Hydrographic data report

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, C.; Behrens, W.J.; Flagg, C.N.; Wallace, D.W.R.; Wilke, R.J.; Wyman, K.D.

    1989-12-01

    The Shelf Edge Exchange Processes (SEEP) program sponsored by the United States Department of Energy is a multi-institutional effort designed to investigate the flux of suspended material from the continental shelf to the waters of the upper slope, and then possibly into the slope sediments. Phase I of SEEP consisted of a series of nine cruises and a mooring array across the outer continental shelf of New England during 1983--1984. Phase II focused specifically on the shelf/slope frontal region of the mid-Atlantic bight off the Delmarva Peninsula. Hydrographic data were collected on eight of the six cruises.

  20. 17 CFR 275.206(3)-3T - Temporary rule for principal trades with certain advisory clients.

    Science.gov (United States)

    2010-04-01

    ... required by 17 CFR 240.10b-10, a conspicuous, plain English statement informing the advisory client that..., sells to or purchases from an advisory client any security if: (1) The investment adviser exercises no... written disclosure required by this section includes a conspicuous, plain English statement that...

  1. Oahu Hyperspectral Imagery 2000 (206-0613-332211) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  2. 48 CFR 206.302-1 - Only one responsible source and no other supplies or services will satisfy agency requirements.

    Science.gov (United States)

    2010-10-01

    ... technological promise, represents the product of original thinking, and was submitted in confidence; or (iii... national defense; or (3) The contract is related to improvement of equipment that is in development...

  3. 18 CFR 1304.206 - Requirements for community docks, piers, boathouses, or other water-use facilities.

    Science.gov (United States)

    2010-04-01

    ... property owners having the right to use the community outlot; (v) Water depths fronting the community lot... management shall be in accordance with the requirements of § 1304.203 except that, at TVA's discretion, the... within or beyond the SMZ may be allowed to enhance views of the reservoir. (c) TVA may approve...

  4. 75 FR 51033 - BE Louisiana, LLC; Notice of Institution of Section 206 Proceeding and Refund Effective Date

    Science.gov (United States)

    2010-08-18

    ... USC 824e, to determine whether the J.P. Morgan Sellers' \\1\\ market-based rate authority in the Cleco... (2010). \\1\\ For purposes of this notice, the J.P. Morgan Sellers are BE Louisiana, LLC, Cedar Brakes...

  5. 44 CFR 206.101 - Temporary housing assistance for emergencies and major disasters declared on or before October 14...

    Science.gov (United States)

    2010-10-01

    ... local codes and ordinances as well as FEMA'S regulations at 44 CFR part 9, Floodplain Management and Protection of Wetlands, and the regulations at 44 CFR part 10, Environmental Considerations. (i) A commercial... floodplain management regulations at 44 CFR part 9. An eligible applicant shall receive one form of...

  6. SU-E-T-206: Improving Radiotherapy Toxicity Based On Artificial Neural Network (ANN) for Head and Neck Cancer Patients

    International Nuclear Information System (INIS)

    Purpose/Objective(s): The aim of this study is to build the estimator of toxicity using artificial neural network (ANN) for head and neck cancer patients Materials/Methods: An ANN can combine variables into a predictive model during training and considered all possible correlations of variables. We constructed an ANN based on the data from 73 patients with advanced H and N cancer treated with external beam radiotherapy and/or chemotherapy at our institution. For the toxicity estimator we defined input data including age, sex, site, stage, pathology, status of chemo, technique of external beam radiation therapy (EBRT), length of treatment, dose of EBRT, status of post operation, length of follow-up, the status of local recurrences and distant metastasis. These data were digitized based on the significance and fed to the ANN as input nodes. We used 20 hidden nodes (for the 13 input nodes) to take care of the correlations of input nodes. For training ANN, we divided data into three subsets such as training set, validation set and test set. Finally, we built the estimator for the toxicity from ANN output. Results: We used 13 input variables including the status of local recurrences and distant metastasis and 20 hidden nodes for correlations. 59 patients for training set, 7 patients for validation set and 7 patients for test set and fed the inputs to Matlab neural network fitting tool. We trained the data within 15% of errors of outcome. In the end we have the toxicity estimation with 74% of accuracy. Conclusion: We proved in principle that ANN can be a very useful tool for predicting the RT outcomes for high risk H and N patients. Currently we are improving the results using cross validation

  7. 44 CFR 206.48 - Factors considered when evaluating a Governor's request for a major disaster declaration.

    Science.gov (United States)

    2010-10-01

    ... the State. We use a figure of $1 per capita as an indicator that the disaster is of such size that it might warrant Federal assistance, and adjust this figure annually based on the Consumer Price Index for all Urban Consumers. We are establishing a minimum threshold of $1 million in public...

  8. 30 CFR 206.53 - How do I determine value for oil that I or my affiliate do(es) not sell under an arm's-length...

    Science.gov (United States)

    2010-07-01

    ... of the oil being valued under this section), the prices of each of the volumes that the refiner...)) / 23,000 bbl = $33.84/bbl. That price will be the value of the oil produced from the lease and refined... transport oil that you or your affiliate sell(s), which is included in the weighted-average...

  9. 30 CFR 206.111 - How do I determine a transportation allowance if I do not have an arm's-length transportation...

    Science.gov (United States)

    2010-07-01

    ... unit-of-production method. After you make an election, you may not change methods without MMS approval... allowance calculations for production after June 1, 2000, beginning at the point on the depreciation... your transportation costs for production before June 1, 2000, using the depreciation schedule based...

  10. Development of a gc×gc-tof/ms based method to study the fate of 206 dioxin-like micropollutants in meat during cooking

    OpenAIRE

    Planche, Christelle; Ratel, Jérémy; Mercier, Frederic; Blinet, Patrick; Debrauwer, Laurent; Engel, Erwan

    2015-01-01

    The aim of the present paper was to develop a multiresidue method based on GC×GC-TOF/MS in order to investigate changes induced by cooking in the composition of a complex food matrix spiked with 226 dioxin-related micropollutants. In a first step, a GC×GC-TOF/MS method was developed to achieve a satisfactory separation of the 209 PCBs and the 17 toxic PCDD/Fs in hexane. The best GC×GC-TOF/MS conditions determined according to peak shape (width and symmetry) and resolution enabled to separate ...

  11. Integrated plant safety assessment: Systematic Evaluation Program, San Onofre Nuclear Generating Station, Unit 1 (Docket No. 50-206): Final report

    International Nuclear Information System (INIS)

    The Systematic Evaluation Program was initiated in February 1977 by the US Nuclear Regulatory Commission to review the designs of older operating nuclear reactor plants to reconfirm and document their safety. The review provides: (1) an assessment of how these plants compare with current licensing safety requirements relating to selected issues; (2) a basis for deciding on how these differences should be resolved in an integrated plant review; and (3) a documented evaluation of plant safety. This report documents the review of San Onofre Nuclear Generating Station, Unit 1, operated by Southern California Edison Company. The San Onofre plant is one of ten plants reviewed under Phase II of this program. This report indicates how 137 topics selected for review under Phase I of the program were addressed. Equipment and procedural changes have been identified as a result of the review. This report will be one of the bases in considering the issuance of a full-term operating license in place of the existing provisional operating license. This report also addresses the comments and recommendations made by the Advisory Committee on Reactor Safeguards in connection with its review of the draft report issued in April 1985

  12. 30 CFR 206.356 - How do I calculate royalty or fees due on geothermal resources I use for direct use purposes?

    Science.gov (United States)

    2010-07-01

    ... of the geothermal resource. That amount of thermal energy (in Btu) displaced by the geothermal... accumulating the amount of thermal energy displaced will be determined and approved by BLM under 43 CFR 3275.13... geothermal production in pounds or gallons of geothermal fluid to input into the fee schedule (see 43...

  13. MicroRNA-1 and MicroRNA-206 Improve Differentiation Potential of Human Satellite Cells : A Novel Approach for Tissue Engineering of Skeletal Muscle

    NARCIS (Netherlands)

    Koning, Merel; Werker, Paul M. N.; van der Schaft, Daisy W. J.; Bank, Ruud A.; Harmsen, Martin C.

    2012-01-01

    Innovative strategies based on regenerative medicine, in particular tissue engineering of skeletal muscle, are promising for treatment of patients with skeletal muscle damage. However, the efficiency of satellite cell differentiation in vitro is suboptimal. MicroRNAs are involved in the regulation o

  14. Nuclear Level Density Parameters of Pb203-209 and Bi206-210 Deformed Target Isotopes Used on Accelerator-Driven Systems in Collective Excitation Modes

    Directory of Open Access Journals (Sweden)

    Şeref Okuducu

    2012-01-01

    Full Text Available The nuclear level density parameters of some deformed isotopes of target nuclei (Pb, Bi used on the accelerator-driven subcritical systems (ADSs have been calculated taking into consideration different collective excitation modes of observed nuclear spectra near the neutron binding energy. The method used in the present work assumes equidistant spacing of the collective coupled state bands of the considered isotopes. The present calculated results for different collective excitation bands have been compared with the compiled values from the literature for s-wave neutron resonance data, and good agreement was found.

  15. 40 CFR 600.206-93 - Calculation and use of fuel economy values for gasoline-fueled, diesel-fueled, electric, alcohol...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Calculation and use of fuel economy... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later Model Year...

  16. 40 CFR 600.206-86 - Calculation and use of fuel economy values for gasoline-fueled, diesel, and electric vehicle...

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later Model Year... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Calculation and use of fuel...

  17. SU-E-J-206: A Comparison of Different Hardware Design Approaches for Feature-Supported Optical Head-Tracking with Respect to Angular Dependencies

    Energy Technology Data Exchange (ETDEWEB)

    Stueber, P; Wissel, T; Wagner, B [Institute for Robotics and Cognitive Systems, University of Luebeck, Luebeck (Germany); Graduate School for Computing in Life Science, University of Luebeck, Luebeck (Germany); Bruder, R; Schweikard, A; Ernst, F [Institute for Robotics and Cognitive Systems, University of Luebeck, Luebeck (Germany)

    2014-06-01

    Purpose: Recent research has shown that optical features significantly improve marker-less optical head-tracking for cranial radiotherapy. Simulations, however, showed that these optical features, which are used to derive tissue thickness, depend on the incident angle of the IR scanning laser beam and the perspective of the camera analyzing the reflective patterns. We present an experimental analysis determining which is the most robust optical setup concerning angular influences. Methods: In three consecutive experiments, the incident angle of the laser (1), the perspective of the camera (2) or both simultaneously (3, ‘inBeam’-perspective) were changed with respect to the target. We analyzed how this affects feature intensity. These intensities were determined from seven concentric regions of interest (ROIs) around the laser spot. Two targets were used: a tissue-like silicone phantom and a human's forehead. Results: For each experiment, the feature intensity generally decreases with increasing angle. We found that the optical properties of the silicone phantom do not fit the properties of human skin. Furthermore, the angular influence of the laser on the features is significantly higher than the perspective of the camera. With the ‘inBeam’- perspective, the smoothest decays of feature intensity were found. We suppose that this is because of a fixed relationship between both devices. This smoothness, suggesting a predictable functional relationship, may simplify angle compensation for machine learning algorithms. This is particularly prominent for the medial ROIs. The inner ROIs highly depend on the angle and power of the laser. The outer ROIs show less angular dependency but the signal strength is critically low and prone to artifacts. Therefore and because of the smooth decays, medial ROIs are a suitable tradeoff between susceptibility, signal-noise-ratio and distance to the center of the laser spot. Conclusion: For tissue thickness correlated feature acquisition, the medial ROIs with the ‘inBeam’-setup provide most valuable features This work was supported by Varian Medical Systems Inc. (Palo Alto, CA, USA). In addition, this work was supported by the Graduate School for Computing in Medicine and Life Sciences funded by Germany's Excellence Initiative [DFG GSC 235/1].

  18. 206/207Pb and Radiocarbon: An Unlikely Pair for Identifying the Source and Delivery Time of Ocean Advection in the South China Sea

    Science.gov (United States)

    Switzer, A.; Goodkin, N.; Bolton, A.; Chen, M.; Druffel, E. R. M.; Boyle, E. A.

    2015-12-01

    Two independent studies were undertaken to use anthropogenic emissions to investigate natural systems using a massive Porites coral taken from off the coast of Vietnam (12ο12'49.90"N, 109 ο18'17.51"E). Annual uptake of bomb radiocarbon (14CO2) was measured to investigate the impact of coastal upwelling; while Pb/Ca levels and Pb isotopes were measured to investigate oceanic infiltration of anthropogenic Pb. Both records reveal a signal of sub-surface seawater advection from the tropical North Pacific to the South China Sea (SCS) providing independent evidence for the source and delivery time of the upwelled water off the coast of Vietnam. The radiocarbon record, extending from 1900-1986 at ~annual resolution, shows a post-bomb peak lower and broader than those found from other corals in the SCS and Japan, but higher than those found in the Makassar Strait in Indonesia. The Makassar coral experiences three water masses: the South Equatorial Current (SEC), upwelled and SCS water. The SEC has a relatively low radiocarbon content. However, water in the SCS does not mix with SEC water that enters the Indonesia Seas via the Halmahera as the main throughflow is from north to south. Hence, the upwelling signature must be from the North Equatorial Current that enters from the Luzon strait at depth. Leaded gasoline was phased-out between 1997 and 2000 in most Asian countries, however unlike other regional records, the Pb/Ca of the coral continued to increase until 2004 indicating a non-atmospheric source of Pb to the region. Both records indicate the source of upwelled water from the tropical North Pacific at roughly ~100-200 meters with a transport time of >2-5 years. This water is carried westward, via the Luzon Strait and into the South China Sea, where is it upwelled during the summer months. A higher resolution study of this coral combined with other coral records from the region could further narrow the location and timing of the advection and upwelling.

  19. [A study using the computer-controlled perimeter Perimat 206 on the effect of Circo-Maren on visual field defects].

    Science.gov (United States)

    Schubert, E; Weber, S

    1988-11-01

    In 1987 an open study was conducted in an ophthalmological practice to test Circo-Maren tablets. Examinations using a computerized perimeter revealed that therapy with Circo-Maren can lead to a reduction in visual field defects in patients with senile macular edema and retinal angiosclerosis. In cases with severe defects, favorable results were achieved which were statistically significant (duration of treatment: 4-12 weeks). Considerable fluctuations in the number and intensity of the defects were seen in the various intermediate examinations. PMID:3062251

  20. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1995-12-01

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

  1. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity...

  2. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Science.gov (United States)

    2010-01-01

    .... Actinium Ac 89 Aluminum Al 13 Americium Am 95 Antimony Sb 51 Argon Ar 18 Arsenic As 33 Astatine At 85... Curium Cm 96 Dysprosium Dy 66 Einsteinium Es 99 Erbium Er 68 Europium Eu 63 Fermium Fm 100 Fluorine F...

  3. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    International Nuclear Information System (INIS)

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons

  4. 培养基组成对冰核生产菌Xanthomonas ampelina TS206产胶率的影响%Effect of Medium Components on Xanthan Gum Ratio from Ice-nucleation Active Bacteria of Xanthomonas ampelina TS206

    Institute of Scientific and Technical Information of China (English)

    李鸿雁; 陈庆森; 阎亚丽; 崔维; 刘磊

    2006-01-01

    培养基中不同的碳源、氮源和无机盐影响冰核细菌的生长、冰核蛋白的表达及黄原胶的产率.蔗糖、麦芽糖和山梨醇均有利于冰核蛋白的生产,而且麦芽糖和山梨醇的产胶率要明显低于其它碳源;蛋白胨和玉米浆均可以作为冰核蛋白生产的优良氮源使用,无机氮不适合作为唯一氮源使用,但适量的KNO3和蛋白胨结合使用时,可以促进菌体的生长和冰核活性的表达,但同时也促进了黄原胶的形成;适量地添加无机盐对菌体的生长和冰核活性的表达有一定的促进作用,对黄原胶的合成没有明显的抑制作用.

  5. Caracterização agronômica e composição química de híbridos de milho - DOI: 10.4025/actascianimsci.v29i2.206 Agronomic evaluation and chemical composition of corn hybrid - DOI: 10.4025/actascianimsci.v29i2.206

    Directory of Open Access Journals (Sweden)

    Augusto Manoel Rodrigues

    2007-11-01

    Full Text Available O trabalho teve por objetivo avaliar a produção de matéria seca total (MST, de colmo (MSc, de folhas (MSf, de espigas (MSe, teores de proteína bruta (PB, fibra em detergente ácido (FDA, altura de planta (AP e relação colmo/folha (C/F de híbridos (Zea mays L. AG 122, AG 519, C 525, C 805, D 170, D 771, G 600, G 1328, P 3041, P 3069, XL 520, XL 530, OC 705, FO 01. Utilizou-se o delineamento experimental inteiramente casualizado, com 10 repetições. O híbrido FO 01 apresentou maior produção de matéria seca, maior altura de planta e maior produção de colmo, porém com menor percentagem de espigas e folhas, prejudicando a qualidade do material original. A maior produtividade apresentada pelos híbridos está associada a maior altura da planta e maior proporção de colmos na matéria seca total. Em geral, uma boa produção de matéria seca, com equilíbrio na relação folhas/colmo/espigas, foi apresentado pelo híbrido G 1328.The objective of this work was to evaluate the total dry matter production (TDMP of stem (DMs, leaves (DMl, ear (DMe, crude protein content (CPC, acid detergent fiber (ADF, plant height (PH and stem/leaves relation (S/L of the hybrids (Zea mays L. AG 122, AG 519, C 525, C 805, D 170, D 771, G 600, G 1328, P 3041, P 3069, XL 520, XL 530, OC 705, FO 01. The results indicated that the hybrid FO 01 showed the highest dry matter production, the highest plant and stem production, but the smallest ear and leaves percentage, decreasing the quality of the original material. The higher productivity of hybrids was associated with a higher plant height and stem production on total dry matter. The hybrid G 1328 showed a good dry matter production with equilibrium in the relation leaves/stem/corn cob.

  6. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  7. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  8. Production cross section of At radionuclides from $^{7}$Li+$^{\\textrm{nat}}$Pb and $^{9}$Be+$^{\\textrm{nat}}$Tl reactions

    CERN Document Server

    Maiti, Moumita

    2011-01-01

    Earlier we reported theoretical studies on the probable production of astatine radionuclides from $^{6,7}$Li and $^{9}$Be-induced reactions on natural lead and thalliun targets, respectively. For the first time, in this report, production of astatine radionuclides has been investigated experimentally with two heavy ion induced reactions: $^{9}$Be+$^{\\textrm{nat}}$Tl and $^{7}$Li+$^{\\textrm{nat}}$Pb. Formation cross sections of the evaporation residues, $^{207,208,209,210}$At, produced in (HI, xn) channel, have been measured by the stacked-foil technique followed by the off-line $\\gamma$-spectrometry at the low incident energies ($<$50 MeV). Measured excitation functions have been explained in terms of compound nuclear reaction mechanism using Weisskopf-Ewing and Hauser-Feshbach model. Absolute cross section values are lower than the respective theoretical predictions.

  9. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  10. Protracted construction of gabbroic crust at a slow spreading ridge: Constraints from 206Pb/238U zircon ages from Atlantis Massif and IODP Hole U1309D (30°N, MAR)

    Science.gov (United States)

    Grimes, Craig B.; John, Barbara E.; Cheadle, Michael J.; Wooden, Joseph L.

    2008-01-01

    Sensitive high-resolution ion microprobe (SHRIMP) U-Pb zircon ages of 24 samples from oceanic crust recovered in Integrated Ocean Drilling Program (IODP) Hole U1309D and from the surface of Atlantis Massif, Mid-Atlantic Ridge (MAR) (30°N) document a protracted history of accretion in the footwall to an oceanic detachment fault. Ages for 18 samples of evolved Fe-Ti oxide gabbro and felsic dikes collected 40–1415 m below seafloor in U1309D yield a weighted mean of 1.20 ± 0.03 Ma (mean square of weighted deviates = 7.1). However, the ages range from 1.08 ± 0.07 Ma and 1.28 ± 0.05 Ma indicating crustal construction occurred over a minimum of 100–200 ka. The zircon ages, along with petrologic observations, indicate at least 2 major periods of intrusive activity with age peaks separated by 70 ka. The oldest ages are observed below 600 mbsf, an observation inconsistent with models requiring constant depth melt intrusion beneath a detachment fault. The data are most consistent with a “multiple sill” model whereby sills intrude at random depths below the ridge axis over a length scale greater than 1.4 km. Zircon ages from broadly spaced samples collected along the southern ridge of Atlantis Massif yield a detachment fault slip rate of 28.7 ± 6.7 mm/a and imply significant asymmetric plate spreading (up to 100% on the North American plate) for at least 200 ka during core complex formation.

  11. Corrigendum to "Recycling of crustal material by the Iceland mantle plume: New evidence from nitrogen elemental and isotope systematics of subglacial basalts" [Geochim. Cosmochim. Acta 176 (2016) 206-226

    Science.gov (United States)

    Halldórsson, Sæmundur A.; Hilton, David R.; Barry, Peter H.; Füri, Evelyn; Grönvold, Karl

    2016-08-01

    In Table 1 of the above published paper, N2/40Ar* ratios (column 13) are incorrect. A corrected table and updated figures (Figs. 6-8) are shown below. The correct N2/40Ar* values vary between 178 and 2.6 × 104, with a mean of 4.1 ± 2.1 (×103). Although this range in N2/40Ar* ratios is somewhat smaller compared to what was reported, it still displays considerably more heterogeneity compared to the DMM database. The new mean value is also significantly higher than the DMM mean (138 ± 65), as discussed. Therefore, the findings in the paper concerning heterogeneous and elevated N2/40Ar* ratios in Icelandic subglacial basalts still stand.

  12. Estimation of physical conditions in the cold phase of the interstellar medium in the sub-DLA system at z = 2.06 in the spectrum of the quasar J 2123-0050

    Science.gov (United States)

    Klimenko, V. V.; Balashev, S. A.; Ivanchik, A. V.; Varshalovich, D. A.

    2016-03-01

    An independent analysis of the molecular hydrogen absorption system at redshift z abs = 2.059 in the spectrum of the quasar J 2123-0050 is presented. The H2 system consists of two components (A and B) with column densities log N_{{H_2}}^A = 17.94 ± 0.01 and N_{{H_2}}^B = 15.16 ± 0.02. The spectrum exhibits the lines of HDmolecules (log N HD A = 13.87±0.06) and the neutral speciesCI and Cl I associated with the H2 absorption system. For the molecular hydrogen lines near the quasar's Ly β and OVI emission lines, we detect a nonzero residual flux, 3% of the total flux, caused by the effect of partial coverage of the quasar's broad-line region by an H2 cloud. Due to the smallness of the residual flux, the effect does not affect the H2 column density being determined but increases the statistics of observations of the partial coverage effect to four cases. The uniqueness of the system being investigated is manifested in a high abundance of the neutral species H2 and CI at the lowest HI column density, log N HI = 19.18 ± 0.15, among the highredshift systems. The H2 and CI column densities in the system being investigated turn out to be higher than those in similar systems in our Galaxy and theMagellanic Clouds by two or three orders ofmagnitude. The N_{HD} /2N_{H_2 } ratio for component A has turned out to be also unusually high, (4.26 ± 0.60) × 10-5, which exceeds the deuterium abundance (D/H) for high-redshift systems by a factor of 1.5. Using the HI, H2, HD, and CI column densities as well as the populations of excited H2 and CI levels, we have investigated the physical conditions in components A and B. Component A represents the optically thick case; the gas has a low number density ( 30 cm-3) and a temperature T 140 K. In component B, the mediumis optically thin with n H ≤ 100 cm-3 and T ≥ 100 K. The ultraviolet (UV) background intensity in the clouds exceeds the mean intensity in our Galaxy by almost an order ofmagnitude. A high gas ionization fraction, n_{H^ + } /n_H ˜ 10^{ - 2}, which can be the result of partial shielding of the systemfrom hard UV radiation, is needed to describe the high HD and CI column densities. Using our simulations with the PDRMeudon code, we can reconstruct the observed column densities of the species within the model with a constant density ( n H 40 cm-3). A high H2 formation rate (higher than the mean Galactic value by a factor of 10-40) and high gas ionization fraction and UV background intensity are needed in this case.

  13. CTD data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT199-206 during 2008 (NCEI Accession 0059842)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  14. Niskin bottle data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT199-206 during 2008 (NCEI Accession 0059936)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  15. Gusto latino : Eliseo R. Colón Zayas, colaboración de Mónica Rector. De Signis 14-Gusto latino. Editorial La Crujía Ediciones, 2009, 206 páginas

    OpenAIRE

    Tram[p]as de la Comunicación y la Cultura

    2010-01-01

    Gusto latino analiza la identidad simbólica de lo latino en la posmodernidad. Lo latino siempre estuvo de moda en el imaginario de moda occidental, pero ahora, con la fuerza de los grandes mecanismos narrativos de la industria cultural de las telenovelas y las nuevas audiencias en el mercado de la música popular, se ha vuelto una cultura planetaria. (Párrafo extraído del texto a modo de resumen)

  16. Estimation of physical conditions in the cold phase of the ISM in the sub-DLA system at z = 2.06 in the spectrum of the quasar J2123-0050

    CERN Document Server

    Klimenko, V V; Ivanchik, A V; Varshalovich, D A

    2016-01-01

    An independent analysis of the molecular hydrogen absorption system at z = 2.059 in the spectrum of the quasar J2123-0050 is presented. The H_2 system consists of two components (A and B) with column densities log N^A(H_2) = 17.94+/-0.01 and log N^B(H_2) = 15.16+/-0.02. The spectrum exhibits the lines of HD molecules (log N^A(HD) = 13.87+/-0.06) and the neutral species C I and Cl I associated with the H_2 absorption system. For the molecular hydrogen lines near the quasar's Ly_beta and O VI emission lines, we detect a nonzero residual flux, ~3% of the total flux, caused by the effect of partial coverage of the quasar's broad-line region by an H_2 cloud. The uniqueness of the system being investigated is manifested in a high abundance of the neutral species H_2 and C I at the lowest H I column density, log N(H I) = 19.18+/-0.15, among the high redshift systems. The N(HD)/2N(H_2) ratio for component A has turned out to be also unusually high, (4.26+/-0.60)x10^{-5}. We have investigated the physical conditions i...

  17. Precambrian crustal evolution and Cretaceous–Palaeogene faulting in West Greenland: 207Pb-206Pb dating of magnetite, monazite and allanite in the central and northern Nagssugtoqidian orogen, West Greenland

    Directory of Open Access Journals (Sweden)

    Frei, Robert

    2006-12-01

    Full Text Available Pb-isotopic data for magnetite from amphibolites in the Nagssugtoqidian orogen, central West Greenland, have been used to trace their source characteristics and the timing of metamorphism. Analyses of the magnetite define a Pb-Pb isochron age of 1726 ± 7 Ma. The magnetite is metamorphic in origin, and the 1726 Ma age is interpreted as a cooling age through the closing temperature of magnetite at ~600°C. Some of the amphibolites in this study come from the Naternaq supracrustal rocks in the northern Nagssugtoqidian orogen, which host the Naternaq sulphide deposit and may be part ofthe Nordre Strømfjord supracrustal suite, which was deposited at around 1950 Ma ago.Pb-isotopic signatures of magnetite from the Arfersiorfik quartz diorite in the central Nagssugtoqidian orogen are compatible with published whole-rock Pb-isotopic data from this suite; previous work has shown that it is a product of subduction-related calc-alkaline magmatism between 1920 and 1870 Ma. Intrusion of pegmatites occurred at around 1800 Ma in both the central and the northernparts of the orogen. Pegmatite ages have been determined by Pb stepwise leaching analyses of allanite and monazite, and source characteristics of Pb point to an origin of the pegmatites by melting of the surrounding late Archaean and Palaeoproterozoic country rocks. Hydrothermal activity took place after pegmatite emplacement and continued below the closure temperature of magnetite at 1800–1650 Ma. Because of the relatively inert and refractory nature of magnetite, Pb-isotopic measurements from this mineral may be of help to understand the metamorphic evolution of geologicallycomplex terrains.

  18. Eficacia de los criterios de identificación del hormigón en la normativa europea (EN 206 y la reglamentación española (EHE-08

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    Revuelta, D.

    2015-12-01

    Full Text Available European and Spanish regulations establish a series of conformity and acceptance criteria for concrete, as well as identity testing. The effectiveness of the first ones has been sufficiently studied by means of Operative Control Curves that provide the probability of acceptance or rejection of conforming concrete. However, it is not possible to find similar studies in the literature about the effectiveness of the identity criteria, despite their relevance in the decision making process for the manufacturer, the authorities and the consumer. In this paper the authors, using Monte Carlo simulation, have investigated the effectiveness of the European and Spanish identity criteria by obtaining curves with the probability of identifying unsolicited concrete and the probability of rejecting a conforming concrete when applying the criteria.La normativa europea y la reglamentación española establecen una serie de criterios de conformidad y aceptación para el hormigón, así como para la identificación del producto servido. La eficacia de los primeros ha sido suficientemente estudiada mediante el análisis de las Curvas Operativas de Control, que proporcionan la probabilidad de aceptación o rechazo de hormigones conformes. Sin embargo no es posible encontrar en la bibliografía trabajos similares sobre la eficacia de los criterios de identificación, a pesar de la importancia que tienen en la toma de decisiones para el fabricante, el legislador y el consumidor. En este trabajo los autores, empleando la simulación de Monte Carlo, han investigado la eficacia de los criterios de identificación europeos y españoles trazando las curvas de probabilidad de identificación de un hormigón no conforme con lo solicitado, y de la probabilidad de rechazo de un hormigón conforme al aplicar estos criterios.

  19. Draft Genome Sequences of Fusobacterium nucleatum ChDC F145, ChDC F174, ChDC F206, and ChDC F300, Isolated from Human Subgingival Plaques in the Republic of Korea

    OpenAIRE

    Park, Soon-Nang; Cho, Eugene; Lim, Yun Kyong; Kim, Hwa-Sook; Kim, Dae-Soo; Jung, Jaeeun; Baek, Jeong-Hun; Jo, Eojin; Chang, Young-Hyo; Shin, Jeong Hwan; Choi, Sang-Haeng; Kang, Jihee; Choi, YongUn; Park, Hong-Seog; Kim, Hongik

    2014-01-01

    Recently, five strains were isolated from human subgingival plaques and were proposed as a novel subspecies of Fusobacterium nucleatum. Here, we report the draft genome sequences of the strains, except one for which the draft sequence was already introduced.

  20. INFLUENCE OF SINTERING TEMPERATURE ON THE POLARIZATION RESISTANCE OF LaO20.6SrO20.4CoO20.2FeO20.8O3-δ - SDC CARBONATE COMPOSITE CATHODE

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    Nurul Akidah Baharuddin

    2016-05-01

    Full Text Available The effects of sintering temperature of an LSCF-samarium-doped ceria carbonate (SDCC cathode composite film on its polarization resistance (Rp were evaluated in this study. An LSCF-SDCC composite cathode was prepared for cathode film development by electrophoretic deposition (EPD. The LSCF-SDCC composite cathode was prepared at 50:50 weight percentage ratio. An EPD suspension which is based on an organic aqueous solution was used, and a mixture of ethanol and deionized water was used as medium with poly diallyl dimethyl ammonium chloride (PDADMAC as a dispersing agent. SDCC substrate was used, and EPD was performed on both sides. A symmetrical cell with cathode composite LSCF-SDCC films on both sides of the substrate was subjected to sintering at five different temperatures (from 550°C to 750°C. A symmetrical cell was painted using silver paste before undergoing electrochemical performance test (air condition, in which the impedance, Z data, was measured. The effects of sintering temperature change on element content and film porosity were first investigated by energy-dispersive X-ray spectroscopy, field emission scanning electron microscopy, and J-image analysis. Ceramic-based cathode LSCF-SDCC that was sintered at 600°C exhibited the lowest Rp at a value of 0.68 Ω when operated at 650°C. This study proved that EPD has potential in developing IT-LT solid oxide fuel cell cathode components with high electrochemical performance in terms of Rp values.