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Sample records for astatine 205

  1. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  2. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  3. Adsorption interaction of astatine species with quartz and gold surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Serov, A. [Paul Scherrer Institute, Villigen (Switzerland). Lab. for Radiochemistry and Environmental Chemistry; Bern Univ. (Switzerland). Dept. for Chemistry and Biochemistry; Aksenov, N.; Bozhikov, G. [Joint Institute for Nuclear Research, Dubna (RU). Flerov Lab. of Nuclear Reactions] (and others)

    2011-07-01

    The adsorption interaction of various astatine species with quartz and gold surfaces was investigated by gas chromatography methods. Due to variations of the redox potential of the carrier gas elemental astatine, astatine oxide and hypo-astatic acid have been produced. The identification of the astatine compounds is based on the analogy assumption to the gas phase chemistry of the closest homologues in group 17 of the periodic table, iodine and bromine. The deposition temperatures as well as enthalpies of adsorption have been determined for the astatine species. The enhancement of the metallic character within group 17 towards higher Z is clearly confirmed. Macroscopic properties (sublimation enthalpy) of previously unstudied AtO{sub 2} and HAtO were estimated. The determined data for elemental astatine were compared to available literature data. Based on the obtained experimental results possible designs of experiments for studying of chemical properties of the recently discovered element 117 can be suggested. (orig.)

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. Discovery of the astatine, radon, francium, and radium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  6. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  7. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  8. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  9. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  10. 9 CFR 205.205 - Fees.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Fees. 205.205 Section 205.205 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE CLEAR TITLE-PROTECTION FOR PURCHASERS OF FARM PRODUCTS...

  11. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  12. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom;

    2015-01-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...... and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting...... vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method...

  13. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  14. ASH ACC 205 NEW Tutorials /ashacc205dotcom

    OpenAIRE

    yamini63

    2015-01-01

    ACC 205 Entire Course(New)   For more course tutorials visit www.ashacc205.com   ACC 205 Week 1 DQ 1 Accounting Equation ACC 205 Week 1 DQ 2 Accounts ACC 205 Week 1 Journal Balance Sheet Journal ACC 205 Week 2 DQ 1 Accounting Cycle ACC 205 Week 2 DQ 2 Bank Reconciliation ACC 205 Week 2 Journal Income Statement Journal ACC 205 Week 3 DQ 1 LIFO vs. FIFO ACC 205 Week 3 DQ 2 Depreciation ACC 205 Week 3 Journal Inventory Journal ACC...

  15. ACC 205 NEW TUTORIAL / Uoptutorial

    OpenAIRE

    Richard

    2015-01-01

    For more course tutorials visit www.uoptutorial.com   ACC 205 Week 1 DQ 1 Accounting Equation   ACC 205 Week 1 DQ 2 Accounts   ACC 205 Week 1 Journal Balance Sheet Journal   ACC 205 Week 2 DQ 1 Accounting Cycle   ACC 205 Week 2 DQ 2 Bank Reconciliation   ACC 205 Week 2 Journal Income Statement Journal   ACC 205 Week 3 DQ 1 LIFO vs. FIFO   ACC 205 Week 3 DQ 2 Depreciation   ...

  16. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  17. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  18. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  19. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  20. 7 CFR 205.240-205.269 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements §§ 205.240-205.269...

  1. 7 CFR 205.407-205.499 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Certification §§ 205.407-205.499...

  2. 7 CFR 205.511-205.599 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Accreditation of Certifying Agents §§ 205.511-205.599...

  3. 7 CFR 205.291-205.299 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements §§ 205.291-205.299...

  4. 7 CFR 205.273-205.289 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements §§ 205.273-205.289...

  5. 7 CFR 205.312-205.399 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Labels, Labeling, and Market Information §§ 205.312-205.399...

  6. 7 CFR 205.623-205.639 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative State Organic Programs §§ 205.623-205.639 Fees...

  7. 7 CFR 205.691-205.699 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Miscellaneous §§ 205.691-205.699...

  8. 7 CFR 205.643-205.649 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Fees §§ 205.643-205.649 Compliance...

  9. 7 CFR 205.666-205.667 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Compliance §§ 205.666-205.667...

  10. 7 CFR 205.208-205.235 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements §§ 205.208-205.235...

  11. 7 CFR 205.106-205.199 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Applicability §§ 205.106-205.199...

  12. ACC 205 NEW ASH Tutorial / Uoptutorial

    OpenAIRE

    Albert Camus

    2015-01-01

    For more course tutorials visit www.uoptutorial.com   ACC 205 Week 1 DQ 1 Accounting Equation   ACC 205 Week 1 DQ 2 Accounts   ACC 205 Week 1 Journal Balance Sheet Journal   ACC 205 Week 2 DQ 1 Accounting Cycle   ACC 205 Week 2 DQ 2 Bank Reconciliation   ACC 205 Week 2 Journal Income Statement Journal   ACC 205 Week 3 DQ 1 LIFO vs. FIFO   ACC 205 Week 3 DQ 2 Depreciation   ...

  13. ACC 205new Course Tutorial / tutorialrank

    OpenAIRE

    welcome8888

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 5 Times, Rating: A+ ACC 205 Week 1 DQ 1 Accounting Equation   ACC 205 Week 1 DQ 2 Accounts   ACC 205 Week 1 Journal Balance Sheet Journal   ACC 205 Week 2 DQ 1 Accounting Cycle   ACC 205 Week 2 DQ 2 Bank Reconciliation   ACC 205 Week 2 Journal Income Statement Journal   ACC 205 Week 3 DQ 1 LIFO vs. FIFO   ACC 205 Week 3...

  14. ACC 205 NEW Tutorial Course/Uoptutorial

    OpenAIRE

    neha

    2015-01-01

    For More Course Tutorials Visit www.uoptutorial.com   ACC 205 Week 1 DQ 1 Accounting Equation   ACC 205 Week 1 DQ 2 Accounts   ACC 205 Week 1 Journal Balance Sheet Journal   ACC 205 Week 2 DQ 1 Accounting Cycle   ACC 205 Week 2 DQ 2 Bank Reconciliation   ACC 205 Week 2 Journal Income Statement Journal   ACC 205 Week 3 DQ 1 LIFO vs. FIFO   ACC 205 Week 3 DQ 2 Depreciation   ...

  15. ACC 205 NEW Course Tutorial / Tutorialrank

    OpenAIRE

    charles

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 5 Times, Rating: A+ ACC 205 Week 1 DQ 1 Accounting Equation   ACC 205 Week 1 DQ 2 Accounts   ACC 205 Week 1 Journal Balance Sheet Journal   ACC 205 Week 2 DQ 1 Accounting Cycle   ACC 205 Week 2 DQ 2 Bank Reconciliation   ACC 205 Week 2 Journal Income Statement Journal   ACC 205 Week 3 DQ 1 LIFO vs. FIFO   ACC 205 Week 3...

  16. 49 CFR 571.205 - Standard No. 205, Glazing materials.

    Science.gov (United States)

    2010-10-01

    ... manufacturer may, at its option, comply with 49 CFR 571.205(a) of this section. S3.2Incorporation by Reference...↓S1”, “A↓S14” and “A↑S2”. Note that the arrow indicating the portion of the material that complies... Motor Vehicle Safety Standards § 571.205 Standard No. 205, Glazing materials. S1. Scope. This...

  17. ACC 205 ASH Tutorial/Uoptutorial

    OpenAIRE

    Stella,, Maurizio

    2015-01-01

    For more course tutorials visit www.uoptutorial.com   ACC 205 Week 1 DQ 1 Accounting Equation  ACC 205 Week 1 DQ 2 Accounts  ACC 205 Week 1 Journal Balance Sheet Journal  ACC 205 Week 2 DQ 1 Accounting Cycle  ACC 205 Week 2 DQ 2 Bank Reconciliation  ACC 205 Week 2 Journal Income Statement Journal  ACC 205 Week 3 DQ 1 LIFO vs. FIFO  ACC 205 Week 3 DQ 2 Depreciation  ACC 205 Week 3 Journal Inventory Journal...

  18. ECO 205 ASH COURSES TUTORIAL/UOPHELP

    OpenAIRE

    ulfaa123

    2015-01-01

    For more course tutorials visit www.uophelp.com   ECO 205 Week 1 CheckPoint Principles of Economics ECO 205 Week 1 DQ 1 and DQ 2 ECO 205 Week 2 CheckPoint Industry Research Part I ECO 205 Week 2 Assignment Supply and Demand (appendix C) ECO 205 Week 3 CheckPoint Industry Research Part II (appendix B) ECO 205 Week 3 DQ 1 and DQ 2 ECO 205 Week 4 CheckPoint International Trade Debate Part I ECO 205 Week 4 CheckPoint International Trade Debate Part &nb...

  19. ECO 205 ASH COURSE Tutorial/UOPHELP

    OpenAIRE

    JOHNY

    2015-01-01

    For more course tutorials visit www.uophelp.com   ECO 205 Week 1 CheckPoint Principles of Economics ECO 205 Week 1 DQ 1 and DQ 2 ECO 205 Week 2 CheckPoint Industry Research Part I ECO 205 Week 2 Assignment Supply and Demand (appendix C) ECO 205 Week 3 CheckPoint Industry Research Part II (appendix B) ECO 205 Week 3 DQ 1 and DQ 2 ECO 205 Week 4 CheckPoint International Trade Debate Part I ECO 205 Week 4 CheckPoint International Trade Debate Part &nb...

  20. ECO 205 uop course tutorial/tutorialoutlet

    OpenAIRE

    naresh 1

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com     ECO 205 Week 1 CheckPoint Principles of Economics ECO 205 Week 1 DQ 1 and DQ 2 ECO 205 Week 2 CheckPoint Industry Research Part I ECO 205 Week 2 Assignment Supply and Demand (appendix C) ECO 205 Week 3 CheckPoint Industry Research Part II (appendix B) ECO 205 Week 3 DQ 1 and DQ 2 ECO 205 Week 4 CheckPoint International Trade Debate Part I ECO 205 Week 4 CheckPoint International Tra...

  1. 7 CFR 205.205 - Crop rotation practice standard.

    Science.gov (United States)

    2010-01-01

    ....205 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements §...

  2. 32 CFR 205.5 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 205.5 Section 205.5 National... USE CERTIFICATES (EUCs) § 205.5 Responsibilities. (a) The Under Secretary of Defense (Acquisition... in § 205.6. This responsibility may not be delegated by the Directors of Defense Agencies; it may...

  3. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  4. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  5. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  6. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  7. ACC 205 NEW Ash Course tutorial/uophelp

    OpenAIRE

    RGNSDD

    2015-01-01

    ACC 205 Week 1 DQ 1 Accounting Equation ACC 205 Week 1 DQ 2 Accounts ACC 205 Week 1 Exercise Assignment Basic Accounting Equations ACC 205 Week 1 Journal Balance Sheet Journal ACC 205 Week 2 DQ 1 Accounting Cycle ACC 205 Week 2 DQ 2 Bank Reconciliation ACC 205 Week 2 Exercise Assignment Revenue and Expenses ACC 205 Week 2 Journal Income Statement Journal ACC 205 Week 3 DQ 1 LIFO vs ACC 205 Week 3 DQ 2 Depreciation ACC 205 Week 3 Exercise Assignment Inventory A...

  8. 48 CFR 231.205 - Selected costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Selected costs. 231.205... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 231.205 Selected costs....

  9. 48 CFR 1331.205 - Selected costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Selected costs. 1331.205... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 1331.205 Selected costs....

  10. 48 CFR 631.205 - Selected costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Selected costs. 631.205... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts with Commercial Organizations 631.205 Selected costs....

  11. 48 CFR 31.205 - Selected costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Selected costs. 31.205... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205 Selected costs....

  12. 48 CFR 931.205 - Selected costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Selected costs. 931.205... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 931.205 Selected costs....

  13. 48 CFR 1231.205 - Selected costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Selected costs. 1231.205... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 1231.205 Selected costs....

  14. 32 CFR 48.205 - Election form.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Election form. 48.205 Section 48.205 National... SERVICEMAN'S FAMILY PROTECTION PLAN Election of Options § 48.205 Election form. The form for making election after October 31, 1968, is prescribed as Election of Options, Retired Serviceman's Family...

  15. 41 CFR 50-205.6 - Complaints.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Complaints. 50-205.6 Section 50-205.6 Public Contracts and Property Management Other Provisions Relating to Public Contracts... AND EMPLOYEES § 50-205.6 Complaints. When a complaint of alleged safety and health violations by...

  16. 20 CFR 655.205 - Recruitment period.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Recruitment period. 655.205 Section 655.205... Agricultural Employment § 655.205 Recruitment period. (a) If the OFLC Administrator determines that the... carry out the assurances contained in § 655.203 with respect to the recruitment of U.S. workers....

  17. 12 CFR 347.205 - Record maintenance.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Record maintenance. 347.205 Section 347.205 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY INTERNATIONAL BANKING Foreign Banks § 347.205 Record maintenance. The records of each insured branch shall...

  18. 33 CFR 117.205 - Connecticut River.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Connecticut River. 117.205 Section 117.205 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Connecticut § 117.205 Connecticut River. (a)...

  19. 50 CFR 648.205 - VMS requirements.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false VMS requirements. 648.205 Section 648.205... Herring Fishery § 648.205 VMS requirements. The owner or operator of any limited access herring vessel with the exception of fixed gear fishermen must install and operate a VMS unit consistent with...

  20. 40 CFR 205.58-2 - Tampering.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Tampering. 205.58-2 Section 205.58-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.58-2 Tampering. (a) For each...

  1. 40 CFR 205.50 - Applicability.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Applicability. 205.50 Section 205.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.50 Applicability. (a) Except as...

  2. 40 CFR 205.54 - Test procedures.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Test procedures. 205.54 Section 205.54 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.54 Test procedures. The procedures...

  3. 40 CFR 205.51 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Definitions. 205.51 Section 205.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.51 Definitions. (a) As used in this...

  4. 40 CFR 205.55 - Requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirements. 205.55 Section 205.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.55 Requirements....

  5. 40 CFR 205.58-1 - Warranty.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Warranty. 205.58-1 Section 205.58-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.58-1 Warranty. (a) The vehicle...

  6. 45 CFR 205.150 - Cost allocation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Cost allocation. 205.150 Section 205.150 Public... ASSISTANCE PROGRAMS § 205.150 Cost allocation. A State plan under title I, IV-A, X, XIV, or XVI (AABD) of the Social Security Act must provide that the State agency will have an approved cost allocation plan on...

  7. 40 CFR 240.205-1 - Requirement.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirement. 240.205-1 Section 240.205-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.205-1...

  8. 47 CFR 97.205 - Repeater station.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Repeater station. 97.205 Section 97.205... SERVICE Special Operations § 97.205 Repeater station. (a) Any amateur station licensed to a holder of a Technician, General, Advanced or Amateur Extra Class operator license may be a repeater. A holder of...

  9. 10 CFR § 205.83 - Contents.

    Science.gov (United States)

    2016-01-01

    ... 10 Energy 3 2016-01-01 2016-01-01 false Contents. § 205.83 Section § 205.83 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Interpretation § 205.83 Contents. (a) The request shall contain a full and complete statement of all relevant facts pertaining to the circumstances,...

  10. 22 CFR 20.5 - Survivor benefits.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Survivor benefits. 20.5 Section 20.5 Foreign Relations DEPARTMENT OF STATE PERSONNEL BENEFITS FOR CERTAIN FORMER SPOUSES § 20.5 Survivor benefits. (a) Type of benefits. A former spouse who meets the eligibility requirements of § 20.3 is entitled...

  11. 40 CFR 240.205 - Air quality.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Air quality. 240.205 Section 240.205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.205 Air quality....

  12. 10 CFR 1015.205 - Credit reports.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Credit reports. 1015.205 Section 1015.205 Energy... Administrative Collection of Claims § 1015.205 Credit reports. (a) In order to aid DOE in making appropriate... administrative costs; and the likelihood of collecting the claim, DOE may institute a credit investigation of...

  13. 40 CFR 89.205 - Banking.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Banking. 89.205 Section 89.205... EMISSIONS FROM NEW AND IN-USE NONROAD COMPRESSION-IGNITION ENGINES Averaging, Banking, and Trading Provisions § 89.205 Banking. (a) Requirements for Tier 1 engines rated at or above 37 kW. (1) A...

  14. 40 CFR 91.205 - Banking.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Banking. 91.205 Section 91.205... EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Averaging, Banking, and Trading Provisions § 91.205 Banking. (a... banking. (i) For outboard engines in model year (MY) 1997, a manufacturer may bank positive...

  15. 40 CFR 90.205 - Banking.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Banking. 90.205 Section 90.205... EMISSIONS FROM NONROAD SPARK-IGNITION ENGINES AT OR BELOW 19 KILOWATTS Certification Averaging, Banking, and Trading Provisions § 90.205 Banking. (a)(1) Beginning August 1, 2007, a manufacturer of a Class I...

  16. 10 CFR 205.7 - Service.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Service. 205.7 Section 205.7 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS General Provisions § 205.7 Service. (a) All orders... personally or by registered or certified mail or by regular United States mail (only when service is...

  17. 48 CFR 17.205 - Documentation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Documentation. 17.205 Section 17.205 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.205 Documentation. (a) The...

  18. 48 CFR 16.205-1 - Description.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Description. 16.205-1 Section 16.205-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 16.205-1 Description. A...

  19. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  20. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  1. ACC 205(NEW) UOP COURSE TUTORIAL/UOPHELP

    OpenAIRE

    MADHU

    2015-01-01

    For more course tutorials visit www.uophelp.com   ACC 205 Week 1 DQ 1 Accounting Equation ACC 205 Week 1 DQ 2 Accounts ACC 205 Week 1 Exercise Assignment Basic Accounting Equations ACC 205 Week 1 Journal Balance Sheet Journal ACC 205 Week 2 DQ 1 Accounting Cycle ACC 205 Week 2 DQ 2 Bank Reconciliation ACC 205 Week 2 Exercise Assignment Revenue and Expenses ACC 205 Week 2 Journal Income Statement Journal ACC 205 Week 3 DQ 1 LIFO vs. FIFO (New) ...

  2. 48 CFR 2131.205-41 - Taxes.

    Science.gov (United States)

    2010-10-01

    ....S.C. 8714(c) or other Federal law prohibits the imposition of taxes, fees, or other monetary... preempted tax is an unallowable expense under FAR 31.205-41(b)(3). (c) Paragraph (b)(1) of FAR 31.205-41 is...) Notwithstanding any other provision in FAR 31.205-41, an amount equal to the “DAC Tax” is an allowable tax...

  3. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  4. 40 CFR 205.151 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Definitions. 205.151 Section 205.151 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION... the rounded off volumetric engine capacity used for marketing purposes by the motorcycle...

  5. 7 CFR 205.104 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false 205.104 Section 205.104 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL...

  6. 7 CFR 205.669 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false 205.669 Section 205.669 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL...

  7. 7 CFR 205.664 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false 205.664 Section 205.664 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL...

  8. 9 CFR 205.201 - System operator.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false System operator. 205.201 Section 205.201 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE CLEAR TITLE-PROTECTION FOR PURCHASERS OF FARM...

  9. 9 CFR 205.106 - Farm products.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Farm products. 205.106 Section 205.106 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE CLEAR TITLE-PROTECTION FOR PURCHASERS OF FARM...

  10. 9 CFR 205.1 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Definitions. 205.1 Section 205.1 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE CLEAR TITLE-PROTECTION FOR PURCHASERS OF FARM...

  11. 9 CFR 205.107 - Crop year.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Crop year. 205.107 Section 205.107 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE CLEAR TITLE-PROTECTION FOR PURCHASERS OF FARM...

  12. 49 CFR 1560.205 - Redress process.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Redress process. 1560.205 Section 1560.205... Redress process. (a) If an individual believes he or she has been improperly or unfairly delayed or... individual may seek assistance through the redress process established under this section. (b) An...

  13. 42 CFR 59.205 - Project requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Project requirements. 59.205 Section 59.205 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR FAMILY PLANNING..., attitudes, or knowledge) that prospective trainees in the area to be served need to improve their...

  14. 7 CFR 205.301 - Product composition.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Product composition. 205.301 Section 205.301 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards..., Except, that, wine containing added sulfites may be labeled “made with organic grapes”; (6) Be...

  15. 38 CFR 3.205 - Marriage.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Marriage. 3.205 Section 3..., Compensation, and Dependency and Indemnity Compensation Evidence Requirements § 3.205 Marriage. (a) Proof of marriage. Marriage is established by one of the following types of evidence: (1) Copy or abstract of...

  16. 33 CFR 136.205 - Compensation allowable.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Compensation allowable. 136.205...) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL LIABILITY TRUST FUND; CLAIMS PROCEDURES; DESIGNATION OF SOURCE; AND ADVERTISEMENT Procedures for Particular Claims § 136.205...

  17. 40 CFR 600.205-77 - Recordkeeping.

    Science.gov (United States)

    2010-07-01

    ....205-77 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later Model Year Automobiles-Procedures for Calculating Fuel Economy Values § 600.205-77 Recordkeeping....

  18. 48 CFR 31.205-7 - Contingencies.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contingencies. 31.205-7 Section 31.205-7 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING... contingencies are generally unallowable for historical costing purposes because such costing deals with...

  19. 19 CFR 205.4 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... EFFECT ON THE ECONOMY OF THE UNITED STATES OF PROPOSED MODIFICATIONS OF DUTIES OR OF ANY BARRIER TO (OR... 19 Customs Duties 3 2010-04-01 2010-04-01 false 205.4 Section 205.4 Customs Duties UNITED STATES... the Probable Economic Effect of Modifications of United States Duties or of Any Barrier to (or...

  20. Cultivar de soja BRS 205

    Directory of Open Access Journals (Sweden)

    Bonato Emídio Rizzo

    2002-01-01

    Full Text Available A BRS 205, cultivar de soja de ciclo semiprecoce, obtida do cruzamento [BR-16(2 x Ocepar 8] x Tracy-M, é indicada para o Rio Grande do Sul, em semeaduras de novembro. Possui crescimento determinado, plantas de flor branca, pubescência marrom, porte baixo e grãos de hilo preto. Tem resistência ao cancro-da-haste (Diaporthe phaseolorum f. sp. meridionalis, à podridão-parda-da-haste (Phialophora gregata, à mancha-olho-de-rã (Cercospora sojina e à pústula bacteriana (Xanthomonas axonopodis pv. glycines. É moderadamente resistente ao oídio (Microsphaera diffusa. O rendimento médio de grãos foi 6% e 11% superior ao das cultivares RS 7-Jacuí e BR-16, respectivamente.

  1. 7 CFR 205.200 - General.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements § 205.200 General....

  2. 7 CFR 205.660 - General.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Compliance § 205.660 General. (a) The National...

  3. 7 CFR 205.404 - Granting certification.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Certification § 205.404 Granting certification. (a) Within a...

  4. 7 CFR 205.237 - Livestock feed.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements § 205.237 Livestock feed....

  5. 7 CFR 205.503 - Applicant information.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Accreditation of Certifying Agents § 205.503 Applicant information....

  6. 7 CFR 205.680 - General.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Adverse Action Appeal Process § 205.680 General....

  7. 7 CFR 205.508 - Site evaluations.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Accreditation of Certifying Agents § 205.508 Site evaluations. (a)...

  8. 7 CFR 205.681 - Appeals.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Adverse Action Appeal Process § 205.681 Appeals....

  9. 7 CFR 205.663 - Mediation.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Compliance § 205.663 Mediation. Any dispute with...

  10. 7 CFR 205.506 - Granting accreditation.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Accreditation of Certifying Agents § 205.506 Granting accreditation....

  11. 7 CFR 205.202 - Land requirements.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements § 205.202 Land...

  12. 7 CFR 205.290 - Temporary variances.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements § 205.290...

  13. 7 CFR 205.500 - Areas and duration of accreditation.

    Science.gov (United States)

    2010-01-01

    ... 205.500 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Accreditation of Certifying Agents § 205.500 Areas...

  14. 7 CFR 205.661 - Investigation of certified operations.

    Science.gov (United States)

    2010-01-01

    ... 205.661 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Compliance § 205.661 Investigation...

  15. 7 CFR 205.103 - Recordkeeping by certified operations.

    Science.gov (United States)

    2010-01-01

    ... 205.103 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Applicability § 205.103 Recordkeeping by...

  16. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  17. 10 CFR 603.205 - Nature of the project.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Nature of the project. 603.205 Section 603.205 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Appropriate Use of Technology Investment Agreements § 603.205 Nature of the project. Judgments relating to the nature of...

  18. 7 CFR 62.205 - Conflict of interest.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Conflict of interest. 62.205 Section 62.205 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Definitions Service § 62.205 Conflict of interest. No USDA official shall review any program documentation...

  19. 9 CFR 113.205 - Newcastle Disease Vaccine, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ... Virus. 113.205 Section 113.205 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.205 Newcastle Disease Vaccine, Killed Virus. Newcastle Disease...

  20. 25 CFR 161.205 - How are range improvements treated?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How are range improvements treated? 161.205 Section 161.205 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER NAVAJO PARTITIONED LANDS GRAZING PERMITS General Provisions § 161.205 How are range improvements treated? (a)...

  1. 40 CFR 205.57-1 - Test request.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Test request. 205.57-1 Section 205.57-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.57-1 Test request. (a)...

  2. 40 CFR 205.57-2 - Test vehicle sample selection.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Test vehicle sample selection. 205.57-2 Section 205.57-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.57-2...

  3. 40 CFR 205.57-8 - Continued testing.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Continued testing. 205.57-8 Section 205.57-8 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.57-8...

  4. 40 CFR 205.58 - In-use requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false In-use requirements. 205.58 Section 205.58 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.58 In-use requirements....

  5. 40 CFR 205.56 - Testing by the Administrator.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Testing by the Administrator. 205.56 Section 205.56 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.56 Testing by...

  6. 40 CFR 205.55-4 - Labeling-compliance.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Labeling-compliance. 205.55-4 Section 205.55-4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.55-4...

  7. 40 CFR 205.57-3 - Test vehicle preparation.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Test vehicle preparation. 205.57-3 Section 205.57-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.57-3 Test...

  8. 40 CFR 205.55-3 - Configuration identification.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Configuration identification. 205.55-3 Section 205.55-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.55-3...

  9. 40 CFR 205.57-4 - Testing procedures.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Testing procedures. 205.57-4 Section 205.57-4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.57-4...

  10. 40 CFR 205.55-2 - Compliance with standards.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Compliance with standards. 205.55-2 Section 205.55-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.55-2...

  11. 40 CFR 205.52 - Vehicle noise emission standards.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Vehicle noise emission standards. 205.52 Section 205.52 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.52...

  12. 40 CFR 205.54-2 - Sound data acquisition system.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Sound data acquisition system. 205.54-2 Section 205.54-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.54-2...

  13. 40 CFR 205.55-5 - Labeling-exterior. [Reserved

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Labeling-exterior. 205.55-5 Section 205.55-5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.55-5...

  14. 40 CFR 205.55-1 - General requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false General requirements. 205.55-1 Section 205.55-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks § 205.55-1...

  15. 48 CFR 615.205-70 - Use of English language.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Use of English language. 615.205-70 Section 615.205-70 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING... Information 615.205-70 Use of English language. The requirements of DOSAR 614.201-70 also apply...

  16. 45 CFR 205.130 - State financial participation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false State financial participation. 205.130 Section 205... ADMINISTRATION-PUBLIC ASSISTANCE PROGRAMS § 205.130 State financial participation. State plan requirements: (a) A State plan for financial assistance under title I, IV-A, X, XIV, or XVI (AABD) of the Social...

  17. 10 CFR 205.81 - What to file.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false What to file. 205.81 Section 205.81 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Interpretation § 205.81 What to file. (a) A person filing under this subpart shall file a “Request for Interpretation,” which should be clearly labeled...

  18. 10 CFR 205.13 - Where to file.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Where to file. 205.13 Section 205.13 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS General Provisions § 205.13 Where to file. (a) Except as otherwise specifically provided in other subparts of this part, all documents to be filed with...

  19. 10 CFR 205.82 - Where to file.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Where to file. 205.82 Section 205.82 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Interpretation § 205.82 Where to file. A request for interpretation shall be filed with the General Counsel or his delegate or with the appropriate Regional...

  20. 48 CFR 631.205-6 - Compensation for personal services.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Compensation for personal services. 631.205-6 Section 631.205-6 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL....205-6 Compensation for personal services. (g)(3) The head of the contracting activity is the...

  1. 48 CFR 231.205-6 - Compensation for personal services.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Compensation for personal services. 231.205-6 Section 231.205-6 Federal Acquisition Regulations System DEFENSE ACQUISITION... PROCEDURES Contracts With Commercial Organizations 231.205-6 Compensation for personal services. (f)(1)...

  2. 33 CFR 101.205 - Department of Homeland Security alignment.

    Science.gov (United States)

    2010-07-01

    ... alignment. 101.205 Section 101.205 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Department of Homeland Security alignment. The MARSEC Levels are aligned with the Department of Homeland... alignment. Table 101.205—Relation Between HSAS and MARSEC Levels Homeland security advisory system...

  3. 12 CFR Appendix B to Part 205 - Federal Enforcement Agencies

    Science.gov (United States)

    2010-01-01

    ... ELECTRONIC FUND TRANSFERS (REGULATION E) Pt. 205, App. B Appendix B to Part 205—Federal Enforcement Agencies The following list indicates which Federal agency enforces Regulation E (12 CFR part 205) for... above Federal Trade Commission, Electronic Fund Transfers, Washington, D.C. 20580....

  4. 40 CFR 205.171 - Selective enforcement auditing (SEA) requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Selective enforcement auditing (SEA) requirements. 205.171 Section 205.171 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Motorcycle Exhaust Systems § 205.171 Selective enforcement auditing...

  5. 40 CFR 205.160 - Selective enforcement auditing (SEA) requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Selective enforcement auditing (SEA) requirements. 205.160 Section 205.160 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Motorcycles § 205.160 Selective enforcement auditing...

  6. 40 CFR 205.3 - Number and gender.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Number and gender. 205.3 Section 205.3... EQUIPMENT NOISE EMISSION CONTROLS General Provisions § 205.3 Number and gender. As used in this part, words in the -singular shall be deemed to import -the plural, and words in the masculine -gender shall...

  7. 48 CFR 3027.205 - Adjustment of royalties.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Adjustment of royalties. 3027.205 Section 3027.205 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY... Patents 3027.205 Adjustment of royalties. (a) Reports shall be made to Component legal...

  8. 49 CFR 375.205 - May I have agents?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false May I have agents? 375.205 Section 375.205... General Responsibilities § 375.205 May I have agents? (a) You may have agents provided you comply with... performs such services only on an emergency or temporary basis. (b) If you have agents, you must...

  9. 48 CFR 1631.205-10 - Cost of money.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Cost of money. 1631.205-10... AND PROCEDURES Contracts With Commercial Organizations 1631.205-10 Cost of money. For the purposes of FAR 31.205-10(b)(3), the estimated facilities capital cost of money is specifically identified if...

  10. 27 CFR 25.205 - Production.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Production. 25.205 Section... Production. (a) Any adult may produce beer, without payment of tax, for personal or family use and not for... that age before commencing the production of beer. This exemption does not authorize the production...

  11. 23 CFR 650.205 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... minimize the time the soil is exposed. Permanent erosion and sediment control measures and practices are..., STRUCTURES, AND HYDRAULICS Erosion and Sediment Control on Highway Construction Projects § 650.205 Definitions. Erosion control measures and practices are actions that are taken to inhibit the dislodging...

  12. 23 CFR 645.205 - Policy.

    Science.gov (United States)

    2010-04-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS UTILITIES Accommodation of Utilities § 645.205 Policy. (a) Pursuant to the provisions of 23 CFR 1.23, it is in the public interest for... location and manner of installation. (d) When utilities cross or otherwise occupy the right-of-way of...

  13. 12 CFR 205.7 - Initial disclosures.

    Science.gov (United States)

    2010-01-01

    ... operator as defined in § 205.16(a)(1), when the consumer initiates an electronic fund transfer or makes a balance inquiry, and by any network used to complete the transaction. (c) Addition of electronic fund... and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM ELECTRONIC...

  14. 41 CFR 109-50.205 - Procedure.

    Science.gov (United States)

    2010-07-01

    ... DISPOSAL AUTHORITIES 50.2-Math and Science Equipment Gift Program § 109-50.205 Procedure. (a) The DOE... math and science projects where the equipment would further enhance the progress of the project. (e... will be used to improve math and science curricula or in the conduct of technical and...

  15. 5 CFR 2640.205 - Employee responsibility.

    Science.gov (United States)

    2010-01-01

    ... action in a matter which an employee knows would affect his financial interest or the interest of another... interest. An employee who is unsure whether an exemption is applicable in a particular case, should consult... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Employee responsibility. 2640.205...

  16. 49 CFR 399.205 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... STANDARDS Step, Handhold, and Deck Requirements for Commercial Motor Vehicles § 399.205 Definitions. Cab...-mounted equipment or machinery or for similar needs. Door sill step Any step normally protected from the....037 Ground The flat horizontal surface on which the tires of a motor vehicle rest. Handhold That...

  17. Production and survival of /sup 205/Pb in stars, and the /sup 205/Pb-/sup 205/Tl s-process chronometry

    Energy Technology Data Exchange (ETDEWEB)

    Yokoi, K.; Takahashi, K.; Arnould, M.

    1985-04-01

    The s-process production ratio of /sup 204/Pb and /sup 205/Pb, which is of importance for the /sup 205/Pb-/sup 205/Tl chronometry, is calculated in two schematic s-process models. Special emphasis is put on the role of the bound-state ..beta../sup -/-decay of /sup 205/Tl which has been totally overlooked in previous studies. It is shown that the /sup 205/Pb production under certain s-process conditions might be large enough to justify a renewed search for extinct /sup 205/Pb in meteorites. The influence of uncertainties in the input quantities (electron capture Q-value and ft values) on the results is also discussed.

  18. Analysis list: Su(var)205 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Su(var)205 Adult,Embryo,Larvae + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3.../target/Su(var)205.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/Su(var)205.5.tsv http://dbarchive.bioscien...cedbc.jp/kyushu-u/dm3/target/Su(var)205.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/c...olo/Su(var)205.Adult.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Su(v...ar)205.Embryo.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Su(var)205.Larvae.tsv http://dbarchive.bioscien

  19. The tidal trail of NGC205?

    CERN Document Server

    McConnachie, A W; Lewis, G; Ibata, R; Chapman, S; Ferguson, A; Tanvir, N

    2004-01-01

    Using data taken as part of the Isaac Newton Telescope Wide Field Camera (INT WFC) survey of M31, we have identified an arc-like overdensity of blue, presumably metal-poor, red giant branch stars in the north-west quadrant of M31. This feature is approximately 1 degree (15 kpc) in extent and has a surface brightness of Sigma_V' ~ 28.5 +/- 0.5 mags per sq. arcsec. The arc appears to emanate from the dwarf elliptical galaxy NGC205, and the colour of its red giant branch is significantly different to the M31 disk population but closely resembles that of NGC205. Further, using data taken with the DEep Imaging Multi-Object Spectrograph (DEIMOS) on Keck II, we identify the radial velocity signature of this arc. Its velocity dispersion is measured to be approximately 10km/s, similar to that of the central regions of NGC205 and typical of stellar streams. Based upon the spatial coincidence of these objects, the surface brightness, the velocity dispersions and the similarity in colour of the red giant branches, we pos...

  20. PE-Cy5.5 conjugates bind to the cells expressing mouse DEC205/CD205

    Science.gov (United States)

    Park, Chae Gyu; Rodriguez, Anthony; Steinman, Ralph M.

    2012-01-01

    DEC205/CD205, an endocytic receptor of C-type multilectin, is expressed highly in dendritic cells (DCs). DEC205 was shown to efficiently deliver vaccine antigens in surrogate ligands to the antigen processing and presentation machinery of DCs, which resulted in the development of DC-targeted vaccines employing anti-DC monoclonal antibodies (mAbs). During our studies to characterize a variety of anti-DC mAbs including anti-DEC205 by flow cytometric analysis, we discovered that a secondary anti-immunoglobulin antibody conjugated with PE-Cy5.5 bound strongly to the cells expressing mouse DEC205 (mDEC205) without incubation of a primary anti-mDEC205 mAb. In the present study we demonstrate that various antibodies and streptavidin conjugated with PE-Cy5.5 bind to the mDEC205-expressing cells including CHO, KIT6, and HEK293 cells. The interaction between the PE-Cy5.5 conjugates and the cells expressing mDEC205 appears distinctive, since none of PE-Cy5.5 conjugates bind to the cells that express human DEC205 on surface. Besides, only PE-Cy5.5 conjugates bind strongly to mDEC205-expressing cells; PerCP-Cy5.5, APC-Cy5.5, and Cy5.5 conjugates bind weakly; PE, PE-Cy5, Cy5, FITC, or Alexa488 conjugates do not bind. Therefore the use of PE-Cy5.5 conjugates, widely utilized in multicolor flow cytometry, requires precaution against nonspecific binding to mDEC205-positive cells. PMID:22841832

  1. 10 CFR 205.308 - Filing schedule and annual reports.

    Science.gov (United States)

    2010-01-01

    ...) Persons authorized to transmit electric energy from the United States shall promptly file all supplements... 10 Energy 3 2010-01-01 2010-01-01 false Filing schedule and annual reports. 205.308 Section 205.308 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Electric Power...

  2. 7 CFR 205.671 - Exclusion from organic sale.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Exclusion from organic sale. 205.671 Section 205.671 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION...

  3. 14 CFR 302.205 - Economic data and other facts.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Economic data and other facts. 302.205... Certificate and Foreign Air Carrier Permit Licensing Proceedings § 302.205 Economic data and other facts. Whenever economic data and other facts are provided in any pleading, such information shall include...

  4. 45 CFR 205.101 - Organization for administration.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Organization for administration. 205.101 Section... PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION-PUBLIC ASSISTANCE PROGRAMS § 205.101 Organization for administration. (a) A State plan...

  5. 9 CFR 205.203 - Place of filing EFS.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Place of filing EFS. 205.203 Section 205.203 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE CLEAR TITLE-PROTECTION FOR PURCHASERS OF...

  6. 9 CFR 205.103 - EFS-minimum information.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false EFS-minimum information. 205.103 Section 205.103 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE CLEAR TITLE-PROTECTION FOR PURCHASERS OF...

  7. 23 CFR 230.205 - Supportive services funds obligation.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Supportive services funds obligation. 230.205 Section 230.205 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS EXTERNAL PROGRAMS Supportive Services for Minority, Disadvantaged, and Women Business Enterprises §...

  8. 17 CFR 205.6 - Sanctions and discipline.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Sanctions and discipline. 205... ISSUER § 205.6 Sanctions and discipline. (a) A violation of this part by any attorney appearing and..., regardless of whether the attorney may also be subject to discipline for the same conduct in a...

  9. 1 CFR 20.5 - Sources of information.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Sources of information. 20.5 Section 20.5... information. Pertinent sources of information useful to the public, in areas of public interest such as... should be provided with each agency statement. These sources of information shall plainly identify...

  10. 48 CFR 231.205-70 - External restructuring costs.

    Science.gov (United States)

    2010-10-01

    ... companies not previously under common ownership or control are combined, whether by merger, acquisition, or... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false External restructuring costs. 231.205-70 Section 231.205-70 Federal Acquisition Regulations System DEFENSE...

  11. 21 CFR 137.205 - Bromated whole wheat flour.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Bromated whole wheat flour. 137.205 Section 137... Cereal Flours and Related Products § 137.205 Bromated whole wheat flour. Bromated whole wheat flour... of ingredients, prescribed for whole wheat flour by § 137.200, except that potassium bromate is...

  12. 40 CFR 205.171-3 - Test motorcycle sample selection.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Test motorcycle sample selection. 205... ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Motorcycle Exhaust Systems § 205.171-3 Test motorcycle sample selection. A test motorcycle to be used for selective enforcement audit...

  13. 49 CFR 377.205 - Presentation of freight bills.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Presentation of freight bills. 377.205 Section 377... Household Goods Freight Forwarders § 377.205 Presentation of freight bills. (a) “To be prepaid” shipments... freight bill or a group of freight bills presented at one time shall state that “failure timely to...

  14. 7 CFR 3560.205 - Rent and utility allowance changes.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Rent and utility allowance changes. 3560.205 Section..., DEPARTMENT OF AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Rents § 3560.205 Rent and utility allowance changes. (a) General. Borrowers must fully document that changes to rents and utility...

  15. 19 CFR 10.205 - Country of origin criteria.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Country of origin criteria. 10.205 Section 10.205... Country of origin criteria. (a) General. Except as otherwise provided in paragraph (b) of this section, an... growth, product, or manufacture of a beneficiary country; or (2) A new or different article of...

  16. 40 CFR 205.57 - Selective enforcement auditing requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Selective enforcement auditing requirements. 205.57 Section 205.57 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks §...

  17. 7 CFR 761.205 - Computing the formula allocation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Computing the formula allocation. 761.205 Section 761..., DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS GENERAL PROGRAM ADMINISTRATION Allocation of Farm Loan Programs Funds to State Offices § 761.205 Computing the formula allocation. (a) The formula allocation for FO...

  18. The [NII] 205 micron Emission in Local Luminous Infrared Galaxies

    CERN Document Server

    Zhao, Yinghe; Xu, C Kevin; Gao, Yu; Lord, Steven D; Charmandaris, Vassilis; Diaz-Santos, Tanio; Evans, Aaron; Howell, Justin; Petric, Andreea O; van der Werf, Paul P; Sanders, David B

    2016-01-01

    In this paper, we present the measurements of the [NII] 205micron line ([NII]205) for a flux-limited sample of 122 (ultra-)luminous infrared galaxies [(U)LIRGs] and 20 additional normal galaxies, obtained with the Herschel Space Observatory. We explore the far-infrared (FIR) color dependence of the [NII]205 (L[NII]205) to the total infrared (LIR) luminosity ratio, and find that L[NII]205/LIR only depends modestly on the 70-to-160 micron flux density ratio (f70/f160) when f70/f160 0.6. We also investigate the relation between L[NII]205 and star formation rate (SFR), and show that L[NII]205 has a nearly linear correlation with SFR, albeit the intercept of such relation varies somewhat with f60/f100, consistent with our previous conclusion that \\NIIab\\ emission can serve as a SFR indicator with an accuracy of ~0.4 dex, or ~0.2 dex if f60/f100 is known independently. Furthermore, together with the ISO measurements of [NII] 122 micron emission we use a total of ~200 galaxies to derive the local [NII]205 luminosit...

  19. 48 CFR 31.205-34 - Recruitment costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Recruitment costs. 31.205... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205-34 Recruitment costs. (a) Subject to paragraph (b) of this subsection, the following costs...

  20. 48 CFR 31.205-26 - Material costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Material costs. 31.205-26... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205-26 Material costs. (a) Material costs include the costs of such items as raw materials,...

  1. 48 CFR 31.205-4 - Bonding costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Bonding costs. 31.205-4... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205-4 Bonding costs. (a) Bonding costs arise when the Government requires assurance against financial loss to...

  2. 48 CFR 31.205-35 - Relocation costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Relocation costs. 31.205... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205-35 Relocation costs. (a) Relocation costs are costs incident to the permanent change of...

  3. 48 CFR 31.205-27 - Organization costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Organization costs. 31.205... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205-27 Organization costs. (a) Except as provided in paragraph (b) of this section, expenditures...

  4. 48 CFR 31.205-30 - Patent costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Patent costs. 31.205-30... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205-30 Patent costs. (a) The following patent costs are allowable to the extent that they are...

  5. 48 CFR 731.205-46 - Travel costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Travel costs. 731.205-46... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 731.205-46 Travel costs. It is USAID policy to require prior written approval of international travel...

  6. 48 CFR 31.205-36 - Rental costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Rental costs. 31.205-36... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205-36 Rental costs. (a) This subsection is applicable to the cost of renting or leasing real...

  7. 48 CFR 31.205-32 - Precontract costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Precontract costs. 31.205... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205-32 Precontract costs. Precontract costs means costs incurred before the effective date of...

  8. 48 CFR 31.205-46 - Travel costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Travel costs. 31.205-46... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205-46 Travel costs. (a) Costs for transportation, lodging, meals, and incidental expenses. (1)...

  9. 48 CFR 1631.205-73 - FEHBP interest expense.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true FEHBP interest expense. 1631.205-73 Section 1631.205-73 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT...) Liquidation of long-term securities would cost more than the cost of the interest; (4) The interest...

  10. 9 CFR 205.101 - Certification-request and processing.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Certification-request and processing. 205.101 Section 205.101 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS..., including, but not limited to, how lists will be organized, and how searches may be performed, using...

  11. 45 CFR 205.70 - Availability of agency program manuals.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Availability of agency program manuals. 205.70... GENERAL ADMINISTRATION-PUBLIC ASSISTANCE PROGRAMS § 205.70 Availability of agency program manuals. State... (AABD) of the Social Security Act must provide that: (a) Program manuals and other policy...

  12. 7 CFR 3018.205 - Professional and technical services.

    Science.gov (United States)

    2010-01-01

    ... and analysis directly applying any professional or technical discipline. For example, drafting of a... 7 Agriculture 15 2010-01-01 2010-01-01 false Professional and technical services. 3018.205 Section....205 Professional and technical services. (a) The prohibition on the use of appropriated funds,...

  13. 22 CFR 519.205 - Professional and technical services.

    Science.gov (United States)

    2010-04-01

    ..., drafting of a legal document accompanying a bid or proposal by a lawyer is allowable. Similarly, technical... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Professional and technical services. 519.205... by Own Employees § 519.205 Professional and technical services. (a) The prohibition on the use...

  14. 22 CFR 227.205 - Professional and technical services.

    Science.gov (United States)

    2010-04-01

    ..., drafting of a legal document accompanying a bid or proposal by a lawyer is allowable. Similarly, technical... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Professional and technical services. 227.205... Activities by Own Employees § 227.205 Professional and technical services. (a) The prohibition on the use...

  15. 10 CFR 601.205 - Professional and technical services.

    Science.gov (United States)

    2010-01-01

    ..., drafting of a legal document accompanying a bid or proposal by a lawyer is allowable. Similarly, technical... 10 Energy 4 2010-01-01 2010-01-01 false Professional and technical services. 601.205 Section 601... Activities by Own Employees § 601.205 Professional and technical services. (a) The prohibition on the use...

  16. 45 CFR 1168.205 - Professional and technical services.

    Science.gov (United States)

    2010-10-01

    ..., drafting of a legal document accompanying a bid or proposal by a lawyer is allowable. Similarly, technical... 45 Public Welfare 3 2010-10-01 2010-10-01 false Professional and technical services. 1168.205... Activities by Own Employees § 1168.205 Professional and technical services. (a) The prohibition on the use...

  17. 38 CFR 45.205 - Professional and technical services.

    Science.gov (United States)

    2010-07-01

    ... or technical discipline. For example, drafting of a legal document accompanying a bid or proposal by... technical services. 45.205 Section 45.205 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... technical services. (a) The prohibition on the use of appropriated funds, in § 45.100(a), does not apply...

  18. 45 CFR 1158.205 - Professional and technical services.

    Science.gov (United States)

    2010-10-01

    ... advice and analysis directly applying any professional or technical discipline. For example, drafting of... 45 Public Welfare 3 2010-10-01 2010-10-01 false Professional and technical services. 1158.205... Own Employees § 1158.205 Professional and technical services. (a) The prohibition on the use...

  19. 41 CFR 105-69.205 - Professional and technical services.

    Science.gov (United States)

    2010-07-01

    ... any professional or technical discipline. For example, drafting of a legal document accompanying a bid... technical services. 105-69.205 Section 105-69.205 Public Contracts and Property Management Federal Property... technical services. (a) The prohibition on the use of appropriated funds, in § 105-69.100 (a), does...

  20. 49 CFR 20.205 - Professional and technical services.

    Science.gov (United States)

    2010-10-01

    ..., drafting of a legal document accompanying a bid or proposal by a lawyer is allowable. Similarly, technical... 49 Transportation 1 2010-10-01 2010-10-01 false Professional and technical services. 20.205... Activities by Own Employees § 20.205 Professional and technical services. (a) The prohibition on the use...

  1. 34 CFR 82.205 - Professional and technical services.

    Science.gov (United States)

    2010-07-01

    ..., drafting of a legal document accompanying a bid or proposal by a lawyer is allowable. Similarly, technical... 34 Education 1 2010-07-01 2010-07-01 false Professional and technical services. 82.205 Section 82... by Own Employees § 82.205 Professional and technical services. (a) The prohibition on the use...

  2. 20 CFR 438.205 - Professional and technical services.

    Science.gov (United States)

    2010-04-01

    ... advice and analysis directly applying any professional or technical discipline. For example, drafting of... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Professional and technical services. 438.205... Own Employees § 438.205 Professional and technical services. (a) The prohibition on the use...

  3. 22 CFR 311.205 - Professional and technical services.

    Science.gov (United States)

    2010-04-01

    ... and analysis directly applying any professional or technical discipline. For example, drafting of a... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Professional and technical services. 311.205... § 311.205 Professional and technical services. (a) The prohibition on the use of appropriated funds,...

  4. 22 CFR 138.205 - Professional and technical services.

    Science.gov (United States)

    2010-04-01

    ..., drafting of a legal document accompanying a bid or proposal by a lawyer is allowable. Similarly, technical... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Professional and technical services. 138.205... Activities by Own Employees § 138.205 Professional and technical services. (a) The prohibition on the use...

  5. 29 CFR 93.205 - Professional and technical services.

    Science.gov (United States)

    2010-07-01

    ... professional or technical discipline. For example, drafting of a legal document accompanying a bid or proposal... 29 Labor 1 2010-07-01 2010-07-01 true Professional and technical services. 93.205 Section 93.205... Professional and technical services. (a) The prohibition on the use of appropriated funds, in § 93.100...

  6. 12 CFR 411.205 - Professional and technical services.

    Science.gov (United States)

    2010-01-01

    ... advice and analysis directly applying any professional or technical discipline. For example, drafting of... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Professional and technical services. 411.205... Activities by Own Employees § 411.205 Professional and technical services. (a) The prohibition on the use...

  7. 7 CFR 65.205 - Perishable agricultural commodity.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Perishable agricultural commodity. 65.205 Section 65... COMMODITIES, MACADAMIA NUTS, PECANS, PEANUTS, AND GINSENG General Provisions Definitions § 65.205 Perishable agricultural commodity. Perishable agricultural commodity means fresh and frozen fruits and vegetables of...

  8. 20 CFR 718.205 - Death due to pneumoconiosis.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Death due to pneumoconiosis. 718.205 Section... DEATH DUE TO PNEUMOCONIOSIS Determining Entitlement to Benefits § 718.205 Death due to pneumoconiosis. (a) Benefits are provided to eligible survivors of a miner whose death was due to pneumoconiosis....

  9. 14 CFR 67.205 - Ear, nose, throat, and equilibrium.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Ear, nose, throat, and equilibrium. 67.205... (CONTINUED) AIRMEN MEDICAL STANDARDS AND CERTIFICATION Second-Class Airman Medical Certificate § 67.205 Ear, nose, throat, and equilibrium. Ear, nose, throat, and equilibrium standards for a second-class...

  10. 46 CFR 109.205 - Inspection of boilers and machinery.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Inspection of boilers and machinery. 109.205 Section 109... OPERATIONS Tests, Drills, and Inspections § 109.205 Inspection of boilers and machinery. The chief engineer or engineer in charge, before he assumes charge of the boilers and machinery of a unit shall...

  11. 45 CFR 205.35 - Mechanized claims processing and information retrieval systems; definitions.

    Science.gov (United States)

    2010-10-01

    ... retrieval systems; definitions. 205.35 Section 205.35 Public Welfare Regulations Relating to Public Welfare... claims processing and information retrieval systems; definitions. Section 205.35 through 205.38 contain State plan requirements for an automated statewide management information system, conditions for FFP...

  12. 7 CFR 205.405 - Denial of certification.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Certification § 205.405 Denial of certification. (a) When the...

  13. 7 CFR 205.236 - Origin of livestock.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements § 205.236 Origin...

  14. 7 CFR 205.662 - Noncompliance procedure for certified operations.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Compliance § 205.662... of a certified operation by a certifying agent or a State organic program's governing State...

  15. 7 CFR 205.505 - Statement of agreement.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Accreditation of Certifying Agents § 205.505 Statement of agreement....

  16. 7 CFR 205.509 - Peer review panel.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Accreditation of Certifying Agents § 205.509 Peer review panel....

  17. 7 CFR 205.306 - Labeling of livestock feed.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Labels, Labeling, and Market Information § 205.306 Labeling of...

  18. 7 CFR 205.665 - Noncompliance procedure for certifying agents.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Compliance § 205.665... applicable State organic program's governing State official all records concerning its...

  19. 7 CFR 205.504 - Evidence of expertise and ability.

    Science.gov (United States)

    2010-01-01

    ....504 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Accreditation of Certifying Agents § 205.504 Evidence...

  20. 7 CFR 205.507 - Denial of accreditation.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Accreditation of Certifying Agents § 205.507 Denial of accreditation....

  1. 7 CFR 205.690 - OMB control number.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Miscellaneous § 205.690 OMB control number. The...

  2. 7 CFR 205.400 - General requirements for certification.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Certification § 205.400 General requirements for certification. A person seeking to receive or maintain organic certification under...

  3. 7 CFR 205.406 - Continuation of certification.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Certification § 205.406 Continuation of certification. (a) To...

  4. 7 CFR 205.501 - General requirements for accreditation.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Accreditation of Certifying Agents § 205... certifying agent under this subpart must: (1) Have sufficient expertise in organic production or...

  5. 7 CFR 205.271 - Facility pest management practice standard.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements § 205.271 Facility pest management practice standard. (a) The producer or handler of an...

  6. 7 CFR 205.502 - Applying for accreditation.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Accreditation of Certifying Agents § 205.502 Applying for...

  7. 7 CFR 205.100 - What has to be certified.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Applicability § 205.100 What has to be certified. (a) Except...

  8. 7 CFR 205.1 - Meaning of words.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Definitions § 205.1 Meaning of words. For the purpose of the...

  9. 7 CFR 205.401 - Application for certification.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Certification § 205.401 Application for certification. A person...

  10. 7 CFR 205.239 - Livestock living conditions.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements § 205.239 Livestock...

  11. 7 CFR 205.402 - Review of application.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Certification § 205.402 Review of application. (a) Upon acceptance of...

  12. 7 CFR 205.672 - Emergency pest or disease treatment.

    Science.gov (United States)

    2010-01-01

    ... 205.672 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Inspection and Testing, Reporting,...

  13. 48 CFR 1631.205-75 - Selling costs.

    Science.gov (United States)

    2010-10-01

    ... enrollees information about their choices among health plans (but see FAR 31.205-1 ‘Public relations and advertising costs’, and The Federal Employees Health Benefits Handbook for Personnel and Payroll...

  14. 48 CFR 31.205-48 - Research and development costs.

    Science.gov (United States)

    2010-10-01

    ... GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial..., means the type of technical effort described in 31.205-18 but sponsored by a grant or required in...

  15. 48 CFR 2131.205-70 - Major subcontractor service charge.

    Science.gov (United States)

    2010-10-01

    ... MANAGEMENT, FEDERAL EMPLOYEES GROUP LIFE INSURANCE FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 2131.205-70 Major... major subcontractor only from the risk charge or service charge negotiated between OPM and...

  16. 48 CFR 1631.205-80 - Major subcontractor service charges.

    Science.gov (United States)

    2010-10-01

    ... insurance risk or underwriting, when costs are determined on the basis of actual costs incurred or... MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 1631.205-80 Major...

  17. 14 CFR 171.205 - Minimum requirements for approval.

    Science.gov (United States)

    2010-01-01

    ... (CONTINUED) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES VHF Marker Beacons § 171.205 Minimum... marker beacon facility under this subpart: (1) The facility's performances, as determined by air...

  18. 48 CFR 1631.205-77 - FEHBP start-up and other nonrecurring costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true FEHBP start-up and other nonrecurring costs. 1631.205-77 Section 1631.205-77 Federal Acquisition Regulations System OFFICE OF PERSONNEL... COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 1631.205-77 FEHBP start-up...

  19. 32 CFR 37.205 - What judgments must I make about the nature of the project?

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false What judgments must I make about the nature of the project? 37.205 Section 37.205 National Defense Department of Defense OFFICE OF THE SECRETARY OF... Investment Agreements § 37.205 What judgments must I make about the nature of the project? You must:...

  20. 45 CFR 170.205 - Content exchange standards and implementation specifications for exchanging electronic health...

    Science.gov (United States)

    2010-10-01

    ... specifications for exchanging electronic health information. 170.205 Section 170.205 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS... TECHNOLOGY Standards and Implementation Specifications for Health Information Technology § 170.205...

  1. 31 CFR 20.205 - What must I include in my drug-free workplace statement?

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false What must I include in my drug-free workplace statement? 20.205 Section 20.205 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Requirements for Recipients Other Than Individuals § 20.205...

  2. 40 CFR 86.205-11 - Introduction; structure of this subpart.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Introduction; structure of this subpart. 86.205-11 Section 86.205-11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Trucks and New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.205-11...

  3. 40 CFR 86.205-94 - Introduction; structure of this subpart.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Introduction; structure of this subpart. 86.205-94 Section 86.205-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Trucks and New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.205-94...

  4. 48 CFR 252.205-7000 - Provision of information to cooperative agreement holders.

    Science.gov (United States)

    2010-10-01

    ... to cooperative agreement holders. 252.205-7000 Section 252.205-7000 Federal Acquisition Regulations... cooperative agreement holders. As prescribed in 205.470, use the following clause: Provision of Information to Cooperative Agreement Holders (DEC 1991) (a) Definition. Cooperative agreement holder means a State or...

  5. Data of evolutionary structure change: 1CTWA-205LA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available W A 1CTWA GHLLTKSPSLNAA ...1CTWA-205LA 1CTW 205L A A MNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSL...ain>205LA GHLLT---AAKSA ure> --- HHH LYS CA 187 SER CA 190 ALA CA 268 1CT...ure> HHHHure> A

  6. 40 CFR 205.57-9 - Prohibition on distribution in commerce; manufacturer's remedy.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Prohibition on distribution in commerce; manufacturer's remedy. 205.57-9 Section 205.57-9 Protection of Environment ENVIRONMENTAL... Medium and Heavy Trucks § 205.57-9 Prohibition on distribution in commerce; manufacturer's remedy....

  7. 14 CFR 1216.205 - Procedures for evaluating NASA actions impacting floodplains and wetlands.

    Science.gov (United States)

    2010-01-01

    ... impacting floodplains and wetlands. 1216.205 Section 1216.205 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION ENVIRONMENTAL QUALITY Floodplain and Wetlands Management § 1216.205 Procedures for evaluating NASA actions impacting floodplains and wetlands. (a) Before taking any action a...

  8. 46 CFR 14.205 - Production of credentials by merchant mariner signing shipping articles.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Production of credentials by merchant mariner signing shipping articles. 14.205 Section 14.205 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT....205 Production of credentials by merchant mariner signing shipping articles. On engagement for...

  9. 10 CFR 205.375 - Guidelines defining inadequate fuel or energy supply.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Guidelines defining inadequate fuel or energy supply. 205.375 Section 205.375 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Electric... Electric Power § 205.375 Guidelines defining inadequate fuel or energy supply. An inadequate utility...

  10. 33 CFR 155.205 - Discharge removal equipment for vessels 400 feet or greater in length.

    Science.gov (United States)

    2010-07-01

    ... vessels 400 feet or greater in length. 155.205 Section 155.205 Navigation and Navigable Waters COAST GUARD... REGULATIONS FOR VESSELS Vessel Equipment § 155.205 Discharge removal equipment for vessels 400 feet or greater in length. (a) Oil tankers and offshore oil barges with an overall length of 400 feet or more...

  11. 14 CFR 205.7 - Cancellation, withdrawal, modification, expiration, or replacement of insurance coverage.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Cancellation, withdrawal, modification, expiration, or replacement of insurance coverage. 205.7 Section 205.7 Aeronautics and Space OFFICE OF THE... LIABILITY INSURANCE § 205.7 Cancellation, withdrawal, modification, expiration, or replacement of...

  12. 7 CFR 205.101 - Exemptions and exclusions from certification.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Applicability § 205.101 Exemptions and... products as “organic” but whose gross agricultural income from organic sales totals $5,000 or less...

  13. 7 CFR 205.620 - Requirements of State organic programs.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Requirements of State organic programs. 205.620... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative State Organic...

  14. 7 CFR 205.403 - On-site inspections.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Certification § 205.403 On-site inspections. (a) On-site inspections....

  15. 40 CFR 205.170 - Testing by the Administrator.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Testing by the Administrator. 205.170... the Administrator. (a)(1) In order for the Administrator to determine whether such exhaust systems or a manufacturer's test facility conform to applicable regulations, the Administrator may require...

  16. 40 CFR 205.159 - Testing by the Administrator.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Testing by the Administrator. 205.159... Administrator. (a)(1) In order for the Administrator to determine whether such vehicles or a manufacturer's test facility conform to applicable regulations, the Administrator may require that vehicles to be...

  17. 40 CFR 205.59 - Recall of noncomplying vehicles.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recall of noncomplying vehicles. 205... of noncomplying vehicles. (a) Pursuant to section 11(d)(1) of the Act, the Administrator may issue an order to the manufacturer to recall and repair or modify any vehicle distributed in commerce not...

  18. 48 CFR 53.205-1 - Paid advertisements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Paid advertisements. 53... (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.205-1 Paid advertisements. SF 1449, prescribed in 53.212, shall be used to place orders for paid advertisements as specified in 5.503....

  19. 33 CFR 106.205 - Company Security Officer (CSO).

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Company Security Officer (CSO...) Facility Security Requirements § 106.205 Company Security Officer (CSO). (a) General. (1) An OCS facility...; (6) Ensure the timely correction of problems identified by audits or inspections; (7)...

  20. 40 CFR 205.155 - Motorcycle class and manufacturer abbreviation.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Motorcycle class and manufacturer...) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Motorcycles § 205.155 Motorcycle class and manufacturer abbreviation. (a) Motorcycles must be grouped into classes determined...

  1. 48 CFR 31.205-28 - Other business expenses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Other business expenses... GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205-28 Other business expenses. The following types of recurring costs are allowable...

  2. 9 CFR 93.205 - Certificate for poultry.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Certificate for poultry. 93.205... AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND POULTRY PRODUCTS;...

  3. 48 CFR 31.205-44 - Training and education costs.

    Science.gov (United States)

    2010-10-01

    ... Organizations 31.205-44 Training and education costs. Costs of training and education that are related to the... follows: (a) Overtime compensation for training and education is unallowable. (b) The cost of salaries for..., scholarships, and fellowships are considered contributions and are unallowable. (e) Training or education...

  4. 48 CFR 1331.205-32 - Precontract costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Precontract costs. 1331... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 1331.205-32 Precontract costs. If precontract costs are anticipated, pursuant to negotiations and...

  5. 48 CFR 31.205-14 - Entertainment costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Entertainment costs. 31... CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 31.205-14 Entertainment costs. Costs of amusement, diversions, social activities, and any...

  6. 45 CFR 1230.205 - Professional and technical services.

    Science.gov (United States)

    2010-10-01

    ... any professional or technical discipline. For example, drafting of a legal document accompanying a bid... 45 Public Welfare 4 2010-10-01 2010-10-01 false Professional and technical services. 1230.205... Professional and technical services. (a) The prohibition on the use of appropriated funds, in § 1230.100...

  7. 32 CFR 28.205 - Professional and technical services.

    Science.gov (United States)

    2010-07-01

    ... or technical discipline. For example, drafting of a legal document accompanying a bid or proposal by... 32 National Defense 1 2010-07-01 2010-07-01 false Professional and technical services. 28.205... technical services. (a) The prohibition on the use of appropriated funds, in § 28.100 (a), does not apply...

  8. 5 CFR 734.205 - Participation in political campaigns.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Participation in political campaigns. 734... REGULATIONS (CONTINUED) POLITICAL ACTIVITIES OF FEDERAL EMPLOYEES Permitted Activities § 734.205 Participation... for political party office; and (f) Take an active part in managing the political campaign of...

  9. 21 CFR 205.4 - Wholesale drug distributor licensing requirement.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Wholesale drug distributor licensing requirement... SERVICES (CONTINUED) DRUGS: GENERAL GUIDELINES FOR STATE LICENSING OF WHOLESALE PRESCRIPTION DRUG DISTRIBUTORS § 205.4 Wholesale drug distributor licensing requirement. Every wholesale distributor in a...

  10. 5 CFR 880.205 - Determinations of death.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Determinations of death. 880.205 Section... Determinations of death. OPM does not make findings of presumed death. A claimant for CSRS, FERS, or FEGLI death... § 880.207 must submit a death certificate or other legal certification of death issued by an...

  11. 31 CFR 548.205 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 548... § 548.205 Evasions; attempts; conspiracies. (a) Except as otherwise authorized, and notwithstanding any... or permit granted prior to the effective date, any conspiracy formed to violate the prohibitions...

  12. 31 CFR 546.205 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 546... § 546.205 Evasions; attempts; conspiracies. (a) Except as otherwise authorized, and notwithstanding any... or permit granted prior to the effective date, any conspiracy formed to violate the prohibitions...

  13. 31 CFR 543.205 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 543... Prohibitions § 543.205 Evasions; attempts; conspiracies. (a) Except as otherwise authorized, and... into or any license or permit granted prior to the effective date, any conspiracy formed to violate...

  14. 31 CFR 544.205 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 544... SANCTIONS REGULATIONS Prohibitions § 544.205 Evasions; attempts; conspiracies. (a) Except as otherwise... contract entered into or any license or permit granted prior to the effective date, any conspiracy...

  15. 31 CFR 586.205 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 586... & MONTENEGRO) KOSOVO SANCTIONS REGULATIONS Prohibitions § 586.205 Evasions; attempts; conspiracies. Any... prohibited. Any conspiracy formed for the purpose of engaging in a transaction prohibited by this part...

  16. 31 CFR 594.205 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 594... Prohibitions § 594.205 Evasions; attempts; conspiracies. (a) Except as otherwise authorized, and... entered into or any license or permit granted prior to the effective date, any conspiracy formed for...

  17. 31 CFR 547.205 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 547... REGULATIONS Prohibitions § 547.205 Evasions; attempts; conspiracies. (a) Except as otherwise authorized, and... into or any license or permit granted prior to the effective date, any conspiracy formed to violate...

  18. 31 CFR 542.205 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 542... § 542.205 Evasions; attempts; conspiracies. (a) Except as otherwise authorized, and notwithstanding any... or any license or permit granted prior to the effective date, any conspiracy formed for the...

  19. 31 CFR 595.205 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 595... § 595.205 Evasions; attempts; conspiracies. Any transaction for the purpose of, or which has the effect... this part is hereby prohibited. Any conspiracy formed for the purpose of engaging in a...

  20. 40 CFR 1065.205 - Performance specifications for measurement instruments.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Performance specifications for... (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Measurement Instruments § 1065.205 Performance specifications for measurement instruments. Your test system as a whole must meet all the applicable...

  1. 33 CFR 110.205 - Chicago Harbor, Ill.

    Science.gov (United States)

    2010-07-01

    ... ANCHORAGE REGULATIONS Anchorage Grounds § 110.205 Chicago Harbor, Ill. (a) The anchorage grounds—(1... beginning. (b) The rules and regulations. (1) Except in cases of emergency, no vessel may be anchored in... making moorings or anchors in place in anchorages A and B. No person may place fixed moorings piles...

  2. 29 CFR 1603.205 - Separation of functions.

    Science.gov (United States)

    2010-07-01

    ... EXEMPT STATE AND LOCAL GOVERNMENT EMPLOYEE COMPLAINTS OF EMPLOYMENT DISCRIMINATION UNDER SECTION 304 OF THE GOVERNMENT EMPLOYEE RIGHTS ACT OF 1991 Hearings § 1603.205 Separation of functions. (a) The... employee engaged in investigating complaints under this part. (b) No Commission employee engaged...

  3. 14 CFR 13.205 - Administrative law judges.

    Science.gov (United States)

    2010-01-01

    ... the administrative law judge imposes any sanction not specified in this subpart, a party may file an... party may file a motion, pursuant to § 13.218(f)(6), requesting that an administrative law judge be... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Administrative law judges. 13.205...

  4. Prognostic significance of miR-205 in endometrial cancer.

    Directory of Open Access Journals (Sweden)

    Mihriban Karaayvaz

    Full Text Available PURPOSE: microRNAs have emerged as key regulators of gene expression, and their altered expression has been associated with tumorigenesis and tumor progression. Thus, microRNAs have potential as both cancer biomarkers and/or potential novel therapeutic targets. Although accumulating evidence suggests the role of aberrant microRNA expression in endometrial carcinogenesis, there are still limited data available about the prognostic significance of microRNAs in endometrial cancer. The goal of this study is to investigate the prognostic value of selected key microRNAs in endometrial cancer by the analysis of archival formalin-fixed paraffin-embedded tissues. EXPERIMENTAL DESIGN: Total RNAs were extracted from 48 paired normal and endometrial tumor specimens using Trizol based approach. The expression of miR-26a, let-7g, miR-21, miR-181b, miR-200c, miR-192, miR-215, miR-200c, and miR-205 were quantified by real time qRT-PCR expression analysis. Targets of the differentially expressed miRNAs were quantified using immunohistochemistry. Statistical analysis was performed by GraphPad Prism 5.0. RESULTS: The expression levels of miR-200c (P<0.0001 and miR-205 (P<0.0001 were significantly increased in endometrial tumors compared to normal tissues. Kaplan-Meier survival analysis revealed that high levels of miR-205 expression were associated with poor patient overall survival (hazard ratio, 0.377; Logrank test, P = 0.028. Furthermore, decreased expression of a miR-205 target PTEN was detected in endometrial cancer tissues compared to normal tissues. CONCLUSION: miR-205 holds a unique potential as a prognostic biomarker in endometrial cancer.

  5. 41 CFR 101-27.205 - Shelf-life codes.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Shelf-life codes. 101-27...-Management of Shelf-Life Materials § 101-27.205 Shelf-life codes. Shelf-life items shall be identified by use of a one-digit code to provide for uniform coding of shelf-life materials by all agencies. (a)...

  6. Completion report for Well Cluster ER-20-5

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The Well Cluster ER-20-5 drilling and completion project was conducted for the US Department of Energy, Nevada Operations Office (DOE/NV), in support of the Nevada Environmental Restoration Project at the Nevada Test Site (NTS) in Nye County, Nevada. Its primary tasks include collecting geological, geophysical, hydrological, and water chemistry data from new and existing wells to define groundwater quality in addition to pathways and rates of groundwater migration. A program of drilling wells near the sites of selected underground nuclear tests (near-field drilling) was implemented to obtain site-specific data about the nature and extent of migration of radionuclides that might have been produced by an underground nuclear explosion. Well Cluster ER-20-5 is the first near-field drilling project initiated at the NTS. This document presents construction data and summarizes the scientific data gathered during the drilling and well-installation phases for all three holes drilled at Well Cluster ER-20-5. Some of this information is preliminary and unprocessed, but was released so that drilling, geotechnical, well design, and completion data could be rapidly disseminated. Additional information about water levels, aquifer testing, and groundwater sampling will be reported after any of this work is performed. Any additional geologic and/or geophysical investigations conducted for this project is described in one or more analysis and interpretation reports. The lithologic and stratigraphic logs, however, are provided in final form.

  7. 7 CFR 205.642 - Fees and other charges for certification.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Fees § 205.642 Fees...

  8. 48 CFR 31.205-43 - Trade, business, technical, and professional activity costs.

    Science.gov (United States)

    2010-10-01

    ... Contracts With Commercial Organizations 31.205-43 Trade, business, technical, and professional activity costs. The following types of costs are allowable: (a) Memberships in trade, business, technical,...

  9. 诺基亚Asha205/206

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    诺基亚一直在不遗余力推出低端入门系列的机型,有人认为它逐渐沦为渣机之王。有人则认为制霸低端市场亦无可厚非。诺基亚最近又“很配合”地推出两款低端新机——Asha 205和206;两款均为非智能机,支持双SIM卡。

  10. Sh2-205: I. The surrounding interstellar medium

    CERN Document Server

    Romero, G A

    2008-01-01

    We present a study of the HII region Sh2-205 and its environs, based on data obtained from the CGPS, 12CO observations, and MSX data. We find that Sh2-205 can be separated in three independent optical structures: SH149.25--0.0, SH 148.83-0.67, and LBN 148.11-0.45. The derived spectral indices show the thermal nature of SH 148.83--0.67 and LBN 148.11--0.45. The morphology of SH 148.83--0.67, both in the optical and radio data, along with the energetic requ irements indicate that this feature is an interstellar bubble powered by the UV photons of HD 24431 (O9 III). LBN 148.11--0.45 has the morphology of a classic al HII region and their ionizing sources remain uncertain. Dust and molecular gas are found related to LBN 148.11-0.45.Particularly, a photodissociation region is detected at the interface between the ionized and molecular regions. If the proposed exciting star HD 24094 were an O8--O9 type star, as suggested by its near-infrared colors, its UV photon flux would be enough to explain the ionization of th...

  11. 31 CFR 575.205 - Prohibited exportation and reexportation of goods, technology, or services to Iraq.

    Science.gov (United States)

    2010-07-01

    ... reexportation of goods, technology, or services to Iraq. 575.205 Section 575.205 Money and Finance: Treasury... goods, technology, or services to Iraq. Except as otherwise authorized, no goods, technology (including... U.S. jurisdiction, exported or reexported from a third country to Iraq, to any entity owned...

  12. Suppression of cell growth and invasion by miR-205 in breast cancer

    Institute of Scientific and Technical Information of China (English)

    Hailong Wu; Shoumin Zhu; Yin-Yuan Mo

    2009-01-01

    MicroRNAs (miRNAs) are endogenous, small, non-coding RNAs, which are capable of silencing gene expression at the post-transcriptional level. In this study, we report that miR-205 is significantly underexpressed in breast tumor compared to the matched normal breast tissue. Similarly, breast cancer cell lines, including MCF-7 and MDA-MB-231, express a lower level miR-205 than the non-malignant MCF-10A cells. Of interest, ectopic expression of miR-205 significantly inhibits cell proliferation and anchorage independent growth, as well as cell invasion. Furthermore, miR-205 was shown to suppress lung metastasis in an animal model. Finally, western blot combined with the luciferase reporter assays demonstrate that ErbB3 and vascular endothelial growth factor A (VEGF-A) are direct targets for miR-205, and this miR-205-mediated suppression is likely through the direct interaction with the putative miR-205 binding site in the 3'-untranslated region (3'-UTR) of ErbB3 and VEGF-A. Together, these results suggest that miR-205 is a tumor suppressor in breast cancer.

  13. 7 CFR 400.205 - Denial or termination of contract and administrative reassignment of business.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Denial or termination of contract and administrative reassignment of business. 400.205 Section 400.205 Agriculture Regulations of the Department of Agriculture (Continued) FEDERAL CROP INSURANCE CORPORATION, DEPARTMENT OF AGRICULTURE GENERAL ADMINISTRATIVE REGULATIONS Agency Sales and...

  14. 33 CFR 263.23 - Small flood control project authority (Section 205).

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Small flood control project..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE CONTINUING AUTHORITIES PROGRAMS Flood Control Policy § 263.23 Small flood control project authority (Section 205). (a) Legislative authority. Section 205 of the...

  15. 45 CFR 205.38 - Federal financial participation (FFP) for establishing a statewide mechanized system.

    Science.gov (United States)

    2010-10-01

    ... financial participation (FFP) for establishing a statewide mechanized system. (a) Effective July 1, 1981... 45 Public Welfare 2 2010-10-01 2010-10-01 false Federal financial participation (FFP) for establishing a statewide mechanized system. 205.38 Section 205.38 Public Welfare Regulations Relating to...

  16. 45 CFR 205.45 - Federal financial participation in relation to State emergency welfare preparedness.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Federal financial participation in relation to State emergency welfare preparedness. 205.45 Section 205.45 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN...

  17. 40 CFR 205.57-6 - Acceptance and rejection of batches.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Acceptance and rejection of batches. 205.57-6 Section 205.57-6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks §...

  18. 40 CFR 205.57-5 - Reporting of the test results.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Reporting of the test results. 205.57-5 Section 205.57-5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks §...

  19. 40 CFR 205.58-3 - Instructions for maintenance, use and repair.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Instructions for maintenance, use and repair. 205.58-3 Section 205.58-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks §...

  20. 40 CFR 205.57-7 - Acceptance and rejection of batch sequence.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Acceptance and rejection of batch sequence. 205.57-7 Section 205.57-7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks §...

  1. 40 CFR Appendix I to Subpart B of... - Appendix I to Subpart B of Part 205

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Appendix I to Subpart B of Part 205 I Appendix I to Subpart B of Part 205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Medium and Heavy Trucks...

  2. 40 CFR 1033.205 - Applying for a certificate of conformity.

    Science.gov (United States)

    2010-07-01

    ... conformity. 1033.205 Section 1033.205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Applying for a certificate of conformity. (a) Send the Designated Compliance Officer a complete application for each engine family for which you are requesting a certificate of conformity. (b) (c) You...

  3. 48 CFR 231.205-18 - Independent research and development and bid and proposal costs.

    Science.gov (United States)

    2010-10-01

    ... allocated more than $1,100,000 in independent research and development and bid and proposal (IR&D/B&P) costs... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Independent research and development and bid and proposal costs. 231.205-18 Section 231.205-18 Federal Acquisition Regulations...

  4. 30 CFR 204.205 - How do I obtain accounting and auditing relief?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I obtain accounting and auditing relief? 204.205 Section 204.205 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and Auditing Relief §...

  5. 48 CFR 2131.205-1 - Public relations and advertising costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Public relations and... REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 2131.205-1 Public relations and advertising costs. The provisions of FAR 31.205-1 shall be modified to include the...

  6. 21 CFR 111.205 - What is the requirement to establish a master manufacturing record?

    Science.gov (United States)

    2010-04-01

    ... manufacturing record? 111.205 Section 111.205 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CURRENT GOOD MANUFACTURING PRACTICE IN MANUFACTURING, PACKAGING, LABELING, OR HOLDING OPERATIONS FOR DIETARY SUPPLEMENTS Production and Process...

  7. 24 CFR 3.205 - Educational institutions and other entities controlled by religious organizations.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Educational institutions and other entities controlled by religious organizations. 3.205 Section 3.205 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX...

  8. 48 CFR 931.205-33 - Professional and consultant service costs.

    Science.gov (United States)

    2010-10-01

    ... expenses are allowable when incurred in accordance with 10 CFR part 719, Contractor Legal Management... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Professional and consultant service costs. 931.205-33 Section 931.205-33 Federal Acquisition Regulations System DEPARTMENT...

  9. 41 CFR 102-41.205 - Do we report all forfeited distilled spirits, wine, and beer to GSA for disposal?

    Science.gov (United States)

    2010-07-01

    ... forfeited distilled spirits, wine, and beer to GSA for disposal? 102-41.205 Section 102-41.205 Public..., and Beer § 102-41.205 Do we report all forfeited distilled spirits, wine, and beer to GSA for disposal? (a) Yes, except do not report distilled spirits, wine, and beer not fit for human consumption or...

  10. 2 CFR 180.205 - Why is it important if a particular transaction is a covered transaction?

    Science.gov (United States)

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Why is it important if a particular transaction is a covered transaction? 180.205 Section 180.205 Grants and Agreements OFFICE OF MANAGEMENT AND... GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Covered Transactions § 180.205 Why is it important if...

  11. 22 CFR 208.205 - Why is it important to know if a particular transaction is a covered transaction?

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Why is it important to know if a particular transaction is a covered transaction? 208.205 Section 208.205 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Covered Transactions § 208.205 Why is...

  12. 5 CFR 919.205 - Why is it important if a particular transaction is a covered transaction?

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Why is it important if a particular transaction is a covered transaction? 919.205 Section 919.205 Administrative Personnel OFFICE OF PERSONNEL... (NONPROCUREMENT) Covered Transactions § 919.205 Why is it important if a particular transaction is a...

  13. 21 CFR 1404.205 - Why is it important if a particular transaction is a covered transaction?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Why is it important if a particular transaction is a covered transaction? 1404.205 Section 1404.205 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Covered Transactions § 1404.205 Why is...

  14. 40 CFR 57.205 - Submission of supplementary information upon relaxation of an SO2 SIP emission limitation.

    Science.gov (United States)

    2010-07-01

    ... upon relaxation of an SO2 SIP emission limitation. 57.205 Section 57.205 Protection of Environment... Application and the NSO Process § 57.205 Submission of supplementary information upon relaxation of an SO2 SIP emission limitation. (a) In the event an SO2 SIP limit is relaxed subsequent to EPA approval or issuance...

  15. 33 CFR 169.205 - What types of ships are required to transmit LRIT information (position reports)?

    Science.gov (United States)

    2010-07-01

    ... SYSTEMS Transmission of Long Range Identification and Tracking Information § 169.205 What types of ships... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What types of ships are required to transmit LRIT information (position reports)? 169.205 Section 169.205 Navigation and...

  16. 48 CFR 31.205-13 - Employee morale, health, welfare, food service, and dormitory costs and credits.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Employee morale, health, welfare, food service, and dormitory costs and credits. 31.205-13 Section 31.205-13 Federal Acquisition... AND PROCEDURES Contracts With Commercial Organizations 31.205-13 Employee morale, health,...

  17. 40 CFR 80.205 - How is the annual refinery or importer average and corporate pool average sulfur level determined?

    Science.gov (United States)

    2010-07-01

    ... average and corporate pool average sulfur level determined? 80.205 Section 80.205 Protection of... ADDITIVES Gasoline Sulfur Gasoline Sulfur Standards § 80.205 How is the annual refinery or importer average and corporate pool average sulfur level determined? (a) The annual refinery or importer average...

  18. Polarized proton collisions at 205 GeV at RHIC.

    Science.gov (United States)

    Bai, M; Roser, T; Ahrens, L; Alekseev, I G; Alessi, J; Beebe-Wang, J; Blaskiewicz, M; Bravar, A; Brennan, J M; Bruno, D; Bunce, G; Courant, E; Drees, A; Fischer, W; Gardner, C; Gill, R; Glenn, J; Haeberli, W; Huang, H; Jinnouchi, O; Kewisch, J; Luccio, A; Luo, Y; Nakagawa, I; Okada, H; Pilat, F; Mackay, W W; Makdisi, Y; Montag, C; Ptitsyn, V; Satogata, T; Stephenson, E; Svirida, D; Tepikian, S; Trbojevic, D; Tsoupas, N; Wise, T; Zelenski, A; Zeno, K; Zhang, S Y

    2006-05-01

    The Brookhaven Relativistic Heavy Ion Collider (RHIC) has been providing collisions of polarized protons at a beam energy of 100 GeV since 2001. Equipped with two full Siberian snakes in each ring, polarization is preserved during acceleration from injection to 100 GeV. However, the intrinsic spin resonances beyond 100 GeV are about a factor of 2 stronger than those below 100 GeV making it important to examine the impact of these strong intrinsic spin resonances on polarization survival and the tolerance for vertical orbit distortions. Polarized protons were first accelerated to the record energy of 205 GeV in RHIC with a significant polarization measured at top energy in 2005. This Letter presents the results and discusses the sensitivity of the polarization survival to orbit distortions. PMID:16712305

  19. Equilibrium and pre-equilibrium emissions in proton-induced reactions on 203,205Tl

    Indian Academy of Sciences (India)

    A Kaplan; A Aydin; E Tel; B Şarer

    2009-02-01

    In this study, the excitation functions for the reactions 203Tl(, )203Pb, 203Tl(, 3)203Pb, 203Tl(, 2)202Pb, 205Tl(, 4)202Pb, 203Tl(, 3)201Pb, 205Tl(, 5)201Pb, 203Tl(, 4)200Pb and 205Tl(, 6)200Pb have been calculated using pre-equilibrium and equilibrium reaction mechanisms. Calculated results based on hybrid model, geometry-dependent hybrid model and cascade-exciton model have been compared with the experimental data.

  20. Investigation of 203,205Hg with the (d,pγ) reaction - identification of the i13/2 neutron hole state in 205Hg

    International Nuclear Information System (INIS)

    Low lying levels in 203Hg and 205Hg were studied with the (d, p) deuteron break-up reaction at Ed=14 and 18 MeV. Gamma-rays and conversion-electrons were measured in coincidence with protons. In addition delayed spectra were recorded with μs and ms beam pulsing. The i13/2 neutron hole state was identified in 205Hg and confirmed in 203Hg. The known level structure of 205Hg below 2 MeV is confirmed and extended. For 203Hg we observe the γ-decay of several levels below 1.5 MeV, which were previously known from transfer reactions. (orig.)

  1. 7 CFR 205.641 - Payment of fees and other charges.

    Science.gov (United States)

    2010-01-01

    ....641 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative Fees § 205.641 Payment of fees and...

  2. 7 CFR 205.300 - Use of the term, “organic.”

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Labels, Labeling, and Market Information § 205.300 Use of the...

  3. 7 CFR 205.272 - Commingling and contact with prohibited substance prevention practice standard.

    Science.gov (United States)

    2010-01-01

    ... Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements § 205.272 Commingling and contact with prohibited...

  4. Tunable Single Frequency 2.05 Micron Fiber Laser Using New Ho-Doped Fiber Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this proposal, we propose to demonstrate and build a widely tunable, narrow linewidth, single frequency fiber laser near 2.05 micron by developing an innovative...

  5. Tunable Narrow Linewidth, Low Noise 2.05 Micron Single Frequency Seeder Laser Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose an all-fiber based 2.05-micron single frequency, narrow linewidth seeder laser with 10 nm tuning range and 5GHz frequency modulation for next generation...

  6. The survival of $^{205}Pb$ in intermediate-mass AGB stars

    CERN Document Server

    Mowlavi, N; Arnould, M; Mowlavi, Nami; Goriely, Stephane; Arnould, Marcel

    1997-01-01

    The now extinct 205Pb is a pure s-process radionuclide (t_{1/2} = 1.5x10^7 y) of possible substantial cosmochemical interest. As a necessary complement to the detailed theoretical study of the nuclear physics and astrophysics aspects of the 205Pb - 205Tl pair carried out by Yokoi et al. (1985), and to the recent calculation of the 205Pb production in Wolf-Rayet stars by Arnould et al. (1997), this paper addresses for the first time in some detail the question of the survival of this radionuclide in thermally pulsing AGB stars. This problem is made difficult by the high sensitivity to temperature and density of the rates of the weak interaction processes that are able to produce or destroy 205Pb. In view of this sensitivity, a recourse to detailed stellar models is mandatory. With the help of some simplifying assumptions concerning in particular the third dredge-up characteristics, some of which (like its depth) being considered as free parameters, predictions are made for the 205Pb contamination of the stella...

  7. Thoracic wall defects: surgical management of 205 consecutive patients

    Energy Technology Data Exchange (ETDEWEB)

    Pairolero, P.C.; Arnold, P.G.

    1986-07-01

    In this article, we review our experience during the past 9 years with 205 consecutive thoracic wall reconstructions. The 100 female and 105 male patients ranged in age from 12 to 85 years (mean, 53.4 years). One hundred fourteen patients had thoracic wall tumors, 56 had radiation necrosis, 56 had infected median sternotomy wounds, and 8 had costochondritis. Twenty-nine of these patients had combinations of the aforementioned conditions. One hundred seventy-eight patients underwent skeletal resection. A mean of 5.4 ribs were resected in 142 patients. Total or partial sternectomies were performed in 60. Skeletal defects were closed with prosthetic material in 66 patients and with autogenous ribs in 12. One hundred sixty-eight patients underwent 244 muscle flap procedures: 149 pectoralis major, 56 latissimus dorsi, 14 rectus abdominis, 13 serratus anterior, 8 external oblique, 2 trapezius, and 2 advancement of diaphragm. The omentum was transposed in 20 patients. The mean number of operations per patient was 1.9 (range, 1 to 8). The mean duration of hospitalization was 16.5 days. One perioperative death occurred (at 29 days). Four patients required tracheostomy. During a mean follow-up of 32.4 months, there were 49 late deaths, predominantly due to malignant disease. All 204 patients who were alive 30 days after operation had excellent surgical results at last follow-up examination or at the time of death due to causes unrelated to the reconstructive procedure.

  8. BeppoSAX observations of the quasar Markarian 205

    International Nuclear Information System (INIS)

    We present the first BeppoSAX observation (0.1 to 220 keV) of the quasar Mrk 205. We have searched for the unusual Fe line profile claimed in the XMM-Newton spectrum which has been widely discussed in recent literature. We find no evidence for a broad, ionized Fe line component in our data. We find that if the continuum is modeled with a Compton reflection from cold material component, the line strength diminishes, in agreement with a recent re-analysis of the XMM-Newton data, but with better constraints on the reflection component thanks to the PDS instrument (15-220 keV). We interpret this fact as another indication for illumination of a distant and cold material rather than reprocessing in the highly ionized inner parts of an accretion disk. We detect for the first time a Compton hump in this object. However we cannot constrain the presence of a high energy cutoff. We confirm the existence of a variable soft excess

  9. Sh2-205: II. Its quiescent stellar formation activity

    CERN Document Server

    Romero, G A

    2009-01-01

    We present a study of active stellar forming regions in the environs of the HII region Sh2-205. The analysis is based on data obtained from point source catalogues and images extracted from 2MASS, MSX, and IRAS surveys. Complementary data are taken from CO survey. The identification of primary candidates to stellar formation activity is made following colour criteria and the correlation with molecular gas emission. A number of stellar formation tracer candidates are projected on two substructures of the HII region: SH148.83-0.67 and SH149.25-0.00. However, the lack of molecular gas related to these structures casts doubts on the nature of the sources. Additional infrared sources may be associated with the HI shell centered at (l,b) = (149\\degr 0\\arcmin, -1\\degr 30\\arcmin). The most striking active area was found in connection to the HII region LBN 148.11-0.45, where stellar formation candidates are projected onto molecular gas. The analytical model to the "collect and collapse" process shows that stellar form...

  10. 20.5万吨散货船的优化设计%Summarization of Optimization Design for 205,000-DWT Type Motor Bulk Carrier

    Institute of Scientific and Technical Information of China (English)

    周云龙

    2012-01-01

    With the rapid development of international shipping industry,especially use of ironstone is increasing.To improve the transport ability and efficiency,increase shipping tonnage,raise economic benefits,ship-owners prefer to constructing the larger bulk carriers which are also the development trend in future.A 205,000-DWT TYPE MOTOR BULK CARRIER is maximum tonnage ship of domestic construction currently.This thesis introduce hull structure optimization design method for the first domestic 205,000-DWT bulk carrier.%随着国际航运业的快速发展,尤其是铁矿石用量的增长,为了提高运输能力和效率,增加单程运输吨位,提高经济效益,船东更倾向建造吨位大的散货船舶。大型散货船也是未来发展的趋势。20.5万吨散货船是目前国内建造的吨位最大的散货船。本文介绍了国内建造的首艘20.5万吨散货船结构优化设计方法

  11. Validation and target gene screening of hsa-miR-205 in lung squamous cell carcinoma

    Institute of Scientific and Technical Information of China (English)

    Huang Wei; Jin Yi; Yuan Yunfeng; Bai Chunxue; Wu Ying; Zhu Hongguang; Lu Shaohua

    2014-01-01

    Background Lung cancers are classified as squamous cell carcinoma (SQ),adenocarcinoma (AC) and small cell lung carcinoma (SCLC).SQ is the major subtype of lung cancer.Currently,there are no targeted therapies for SQ due to lack of understanding its driving oncogenes.In this study,we validated an SQ specific biomarker hsa-miR-205 in Chinese patients with lung cancer and screened its candidate target genes for further functional studies to enrich knowledge in SQ target therapies.Methods Quantitative reverse-transcription PCR (quantitative RT-PCR)was performed on 197 macro-dissected (cancerous cells >75%) surgical lung tissues (45 SQ,44 AC,54 SCLC and 54 adjacent normal tissues) to validate the expression profiles of miR-205.Furthermore,the targets of this microRNA were predicted through the gateway miRecords and mapped to lung cancer-associated pathways using the KEGG (Kyoto Encyclopedia of Genes and Genomes) database.Then quantitative RT-PCR was performed on an independent cohort of 44 snap-frozen surgical lung tissues to concurrently assess the expression profiles of miR-205 and its 52 putative targeted genes.Results MicroRNA-205 yielded high diagnostic accuracy in discriminating SQ from AC with an area under the curve (AUC) of 0.985,and discriminating SQ from SCLC with an AUC of 0.978 in formalin-fixed paraffin-embedded (FFPE)surgical lung tissues.Predicted targets of miR-205 were associated with 52 key members of lung cancer signaling pathways.Ten target genes (ACSL1,AXIN2,CACNA2D2,FOXO3,PPP1R3A,PRKAG3,RUNX1,SMAD4,STK3 and TBL1XR1) were significantly down-regulated in SQ and had a strong negative correlation with miR-205,while one target gene (CDH3) was up-regulated in SQ and exhibited a strong positive correlation with miR-205.Conclusions We confirmed the high diagnostic accuracy of miR-205 in discriminating SQ from AC and SCLC in Chinese patients.Moreover,we identified 11 significant target genes of miR-205 which could be used for further functional studies

  12. Vectorization of molecular dynamics Fortran programs using the cyber 205 vector processing computer

    Science.gov (United States)

    Vogelsang, R.; Schoen, M.; Hoheisel, C.

    1983-11-01

    A concept of vectorization of molecular dynamics Fortran programs for the use of the Cyber 205 machine is presented. It is shown that for calculations with larger particle systems the program runs faster on the 205 than on the Cray-1 by about a factor of two. Against conventional computers like the Cyber 175 an acceleration by a factor 10-15 is expected. A bit control vector is used instead of a neighbour list, which in principal provides calculations up to 6912 particles for the memory capacity of the Cyber 205. However, because the application of the bit vector requires computation times which grow proportional to N2, the CPU time for particle numbers of more than 2048 becomes prohibitively large.

  13. Targeting of rotavirus VP6 to DEC-205 induces protection against the infection in mice.

    Science.gov (United States)

    Badillo-Godinez, O; Gutierrez-Xicotencatl, L; Plett-Torres, T; Pedroza-Saavedra, A; Gonzalez-Jaimes, A; Chihu-Amparan, L; Maldonado-Gama, M; Espino-Solis, G; Bonifaz, L C; Esquivel-Guadarrama, F

    2015-08-20

    Rotavirus (RV) is the primary etiologic agent of severe gastroenteritis in human infants. Although two attenuated RV-based vaccines have been licensed to be applied worldwide, they are not so effective in low-income countries, and the induced protection mechanisms have not been clearly established. Thus, it is important to develop new generation vaccines that induce long lasting heterotypic immunity. VP6 constitutes the middle layer protein of the RV virion. It is the most conserved protein and it is the target of protective T-cells; therefore, it is a potential candidate antigen for a new generation vaccine against the RV infection. We determined whether targeting the DEC-205 present in dendritic cells (DCs) with RV VP6 could induce protection at the intestinal level. VP6 was cross-linked to a monoclonal antibody (mAb) against murine DEC-205 (αDEC-205:VP6), and BALB/c mice were inoculated subcutaneously (s.c.) twice with the conjugated containing 1.5 μg of VP6 in the presence of polyinosinic-polycytidylic acid (Poly I:C) as adjuvant. As controls and following the same protocol, mice were immunized with ovalbumin (OVA) cross-linked to the mAb anti-DEC-205 (αDEC-205:OVA), VP6 cross-linked to a control isotype mAb (Isotype:VP6), 3 μg of VP6 alone, Poly I:C or PBS. Two weeks after the last inoculation, mice were orally challenged with a murine RV. Mice immunized with α-DEC-205:VP6 and VP6 alone presented similar levels of serum Abs to VP6 previous to the virus challenge. However, after the virus challenge, only α-DEC-205:VP6 induced up to a 45% IgA-independent protection. Memory T-helper (Th) cells from the spleen and the mesenteric lymph node (MLN) showed a Th1-type response upon antigen stimulation in vitro. These results show that when VP6 is administered parenterally targeting DEC-205, it can induce protection at the intestinal level at a very low dose, and this protection may be Th1-type cell dependent.

  14. 7 CFR 205.621 - Submission and determination of proposed State organic programs and amendments to approved State...

    Science.gov (United States)

    2010-01-01

    ..., Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL... 7 Agriculture 3 2010-01-01 2010-01-01 false Submission and determination of proposed State organic programs and amendments to approved State organic programs. 205.621 Section 205.621 Agriculture...

  15. 7 CFR 205.307 - Labeling of nonretail containers used for only shipping or storage of raw or processed...

    Science.gov (United States)

    2010-01-01

    ..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT... or âmade with organic (specified ingredients or food group(s)).â 205.307 Section 205.307 Agriculture... percent organic,” “organic,” or “made with organic (specified ingredients or food group(s)).”...

  16. 45 CFR 205.25 - Eligibility of supplemental security income beneficiaries for food stamps or surplus commodities.

    Science.gov (United States)

    2010-10-01

    ....25 Eligibility of supplemental security income beneficiaries for food stamps or surplus commodities... 45 Public Welfare 2 2010-10-01 2010-10-01 false Eligibility of supplemental security income beneficiaries for food stamps or surplus commodities. 205.25 Section 205.25 Public Welfare Regulations...

  17. 24 CFR 570.205 - Eligible planning, urban environmental design and policy-planning-management-capacity building...

    Science.gov (United States)

    2010-04-01

    ... environmental design and policy-planning-management-capacity building activities. 570.205 Section 570.205..., urban environmental design and policy-planning-management-capacity building activities. (a) Planning... known or suspected environmental contamination. (5) (6) Policy—planning—management—capacity...

  18. 24 CFR 1003.205 - Eligible planning, urban environmental design and policy-planning-management-capacity building...

    Science.gov (United States)

    2010-04-01

    ... environmental design and policy-planning-management-capacity building activities. 1003.205 Section 1003.205... planning, urban environmental design and policy-planning-management-capacity building activities. (a... cost of such activities under §§ 1003.201 through 1003.204. (b)...

  19. 31 CFR 500.205 - Holding of certain types of blocked property in interest-bearing accounts.

    Science.gov (United States)

    2010-07-01

    ... “domestic bank” includes any FSLIC-insured institution (as defined in 12 CFR 561.1). (j) For the purposes of... property in interest-bearing accounts. 500.205 Section 500.205 Money and Finance: Treasury Regulations... interest-bearing accounts. (a) Except as provided by paragraphs (d), (e) and (f) of this section, or...

  20. 31 CFR 515.205 - Holding of certain types of blocked property in interest-bearing accounts.

    Science.gov (United States)

    2010-07-01

    ... domestic bank includes any FSLIC-insured institution (as defined in 12 CFR 561.1). (j) For the purposes of... property in interest-bearing accounts. 515.205 Section 515.205 Money and Finance: Treasury Regulations... interest-bearing accounts. (a) Except as provided by paragraphs (d), (e) and (f) of this section, or...

  1. 48 CFR 50.205-3 - Authorization of offers contingent upon SAFETY Act designation or certification before contract...

    Science.gov (United States)

    2010-10-01

    ... CONTRACTUAL ACTIONS AND THE SAFETY ACT Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.205-3 Authorization of offers contingent upon SAFETY Act designation or certification before... contingent upon SAFETY Act designation or certification before contract award. 50.205-3 Section...

  2. 48 CFR 50.205-4 - Authorization of awards made presuming SAFETY Act designation or certification after contract award.

    Science.gov (United States)

    2010-10-01

    ... CONTRACTUAL ACTIONS AND THE SAFETY ACT Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.205-4 Authorization of awards made presuming SAFETY Act designation or certification after... made presuming SAFETY Act designation or certification after contract award. 50.205-4 Section...

  3. 31 CFR 593.205 - Prohibition on the importation of any round log or timber product originating in Liberia.

    Science.gov (United States)

    2010-07-01

    ... round log or timber product originating in Liberia. 593.205 Section 593.205 Money and Finance: Treasury... on the importation of any round log or timber product originating in Liberia. Except as otherwise... section, the importation into the United States, directly or indirectly, of any round log or...

  4. 25 CFR 162.205 - Can individual Indian landowners exempt their agricultural land from certain tribal leasing...

    Science.gov (United States)

    2010-04-01

    ... agricultural land from certain tribal leasing policies? 162.205 Section 162.205 Indians BUREAU OF INDIAN... leasing policies? (a) Individual Indian landowners may exempt their agricultural land from the application of a tribal leasing policy of a type described in § 162.203(b) through (c) of this subpart, if...

  5. 48 CFR 31.205-16 - Gains and losses on disposition or impairment of depreciable property or other capital assets.

    Science.gov (United States)

    2010-10-01

    ... disposition or impairment of depreciable property or other capital assets. 31.205-16 Section 31.205-16 Federal... or impairment of depreciable property or other capital assets. (a) Gains and losses from the sale... which they occur as credits or charges to the cost grouping(s) in which the depreciation or...

  6. 19 CFR 205.6 - Investigations under section 301(e)(3) of the Trade Act of 1974.

    Science.gov (United States)

    2010-04-01

    ... Economy of the United States of the President's Taking Retaliatory Action To Obtain the Elimination of... probable impact on the economy of the United States of imposing retaliatory restrictions on imports into... Trade Act of 1974. 205.6 Section 205.6 Customs Duties UNITED STATES INTERNATIONAL TRADE...

  7. 48 CFR 931.205-18 - Independent research and development (IR&D) and bid and proposal (B&P) costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Independent research and development (IR&D) and bid and proposal (B&P) costs. 931.205-18 Section 931.205-18 Federal Acquisition... PROCEDURES Contracts With Commercial Organizations 931.205-18 Independent research and development (IR&D)...

  8. 7 CFR 205.622 - Review of approved State organic programs.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Review of approved State organic programs. 205.622... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Administrative State Organic...

  9. 7 CFR 205.102 - Use of the term, “organic.”

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Applicability § 205.102 Use of the term, “organic.” Any...

  10. 7 CFR 205.201 - Organic production and handling system plan.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Organic production and handling system plan. 205.201... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and...

  11. 12 CFR 268.205 - Employment of aliens; Access to sensitive information.

    Science.gov (United States)

    2010-01-01

    ... Complaints § 268.205 Employment of aliens; Access to sensitive information. (a) Definitions. The definitions... supervisory information of the Board, as defined in 12 CFR 261.2(c). Three internal security designations.... 1160(a) or section 1255a(a)(1), is admitted as a refugee under 8 U.S.C. 1157, or is granted...

  12. 14 CFR 145.205 - Maintenance, preventive maintenance, and alterations performed for certificate holders under...

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Maintenance, preventive maintenance, and...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.205 Maintenance, preventive.... (a) A certificated repair station that performs maintenance, preventive maintenance, or...

  13. 45 CFR 150.205 - Sources of information triggering an investigation of State enforcement.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Sources of information triggering an investigation... § 150.205 Sources of information triggering an investigation of State enforcement. Information that may... complaint received by CMS. (b) Information learned during informal contact between CMS and State...

  14. 12 CFR 205.9 - Receipts at electronic terminals; periodic statements.

    Science.gov (United States)

    2010-01-01

    ... applicable: (1) Transaction information. For each electronic fund transfer occurring during the cycle: (i... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Receipts at electronic terminals; periodic... RESERVE SYSTEM ELECTRONIC FUND TRANSFERS (REGULATION E) § 205.9 Receipts at electronic terminals;...

  15. 34 CFR 403.205 - What are the State's responsibilities for members of special populations?

    Science.gov (United States)

    2010-07-01

    ... APPLIED TECHNOLOGY EDUCATION PROGRAM What Are the Administrative Responsibilities of a State Under the State Vocational and Applied Technology Education Program? § 403.205 What are the State's... 34 Education 3 2010-07-01 2010-07-01 false What are the State's responsibilities for members...

  16. 40 CFR 88.205-94 - California Pilot Test Program Credits Program.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false California Pilot Test Program Credits...) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES California Pilot Test Program § 88.205-94 California Pilot Test Program Credits Program. (a) General. (1) The Administrator shall administer this...

  17. 48 CFR 50.205-2 - Pre-qualification designation notice.

    Science.gov (United States)

    2010-10-01

    ... REGULATION CONTRACT MANAGEMENT EXTRAORDINARY CONTRACTUAL ACTIONS AND THE SAFETY ACT Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.205-2 Pre-qualification designation notice. (a) Requiring... qualify for SAFETY Act protection, the requiring activity is responsible for requesting a...

  18. 31 CFR 205.2 - What definitions apply to this part?

    Science.gov (United States)

    2010-07-01

    ... unless otherwise specified. Default procedures means efficient cash management practices that we...) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE RULES AND PROCEDURES FOR EFFICIENT FEDERAL-STATE FUNDS TRANSFERS § 205.2 What definitions apply to this part? For purposes of...

  19. 31 CFR 205.1 - What Federal assistance programs are covered by this part?

    Science.gov (United States)

    2010-07-01

    ... Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE RULES AND PROCEDURES FOR EFFICIENT FEDERAL-STATE FUNDS TRANSFERS § 205.1 What Federal assistance programs are covered... the Prompt Payment Act of 1982, as amended, 31 U.S.C. 3901 et seq., 5 CFR part 1315, and 48 CFR...

  20. 40 CFR 205.54-1 - Low speed sound emission test procedures.

    Science.gov (United States)

    2010-07-01

    ... shall be the triangular paved (concrete or sealed asphalt) area formed by the acceleration point, the... area (BCD in figure 205.1) shall be smooth concrete or smooth sealed asphalt, free of extraneous material such as gravel. EC01FE92.052 (13) Vehicles with diesel engines shall be tested using Number 1D...

  1. 41 CFR 101-25.205 - Arrangement for performance of purchasing functions other than centralized.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Arrangement for... Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 25-GENERAL 25.2-Interagency Purchase Assignments § 101-25.205 Arrangement...

  2. 10 CFR 205.199A - Hearing for the purpose of oral argument only.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Hearing for the purpose of oral argument only. 205.199A... Hearing for the purpose of oral argument only. (a) A participant is entitled upon timely request to a... the purpose of receiving oral argument will generally be conducted only after the issues involved...

  3. 48 CFR 31.205-18 - Independent research and development and bid and proposal costs.

    Science.gov (United States)

    2010-10-01

    ... Contracts With Commercial Organizations 31.205-18 Independent research and development and bid and proposal..., defined in this subsection. Basic research, (See 2.101). Bid and proposal (B&P) costs means the costs... 9904.420, Accounting for independent research and development costs and bid and proposal costs,...

  4. 48 CFR 231.205-1 - Public relations and advertising costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Public relations and... PROCEDURES Contracts With Commercial Organizations 231.205-1 Public relations and advertising costs. (e) See... public relations and advertising costs also include monies paid to the Government associated with...

  5. 48 CFR 1631.205-70 - FEHBP public relations and advertising costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true FEHBP public relations and... COST PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 1631.205-70 FEHBP public relations and advertising costs. (a) The cost of media messages that are directed at advising current...

  6. 46 CFR 180.205 - Survival craft-vessels operating on limited coastwise routes.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Survival craft-vessels operating on limited coastwise... Craft § 180.205 Survival craft—vessels operating on limited coastwise routes. (a) Except as allowed by... survival craft required by § 180.204(d). (e) Each vessel certificated to operate on a limited...

  7. 46 CFR 117.205 - Survival craft-vessels operating on limited coastwise routes.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Survival craft-vessels operating on limited coastwise... PASSENGERS LIFESAVING EQUIPMENT AND ARRANGEMENTS Number and Type of Survival Craft § 117.205 Survival craft... the survival craft required by §§ 117.204 (a) through (d) of this part, as applicable. (b) Each...

  8. 40 CFR 205.171-8 - Passing or failing under SEA.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Passing or failing under SEA. 205.171... Passing or failing under SEA. (a) A failing exhaust system is one which, when installed on any motorcycle... equal to the number in Column A, the sample passes. (c) Pass or failure of a SEA takes place when...

  9. 40 CFR 205.160-6 - Passing or failing under SEA.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Passing or failing under SEA. 205.160... failing under SEA. (a) A failing vehicle is one whose measured noise level is in excess of the applicable... vehicles is less than or equal to the number in Column A, the sample passes. (c) Pass or failure of an...

  10. 40 CFR 205.160-2 - Test sample selection and preparation.

    Science.gov (United States)

    2010-07-01

    ...) NOISE ABATEMENT PROGRAMS TRANSPORTATION EQUIPMENT NOISE EMISSION CONTROLS Motorcycles § 205.160-2 Test... performed by the manufacturer on like products during early production if the resulting testing is not... be installed on the vehicle if such equipment or fixtures have no effect on the noise emissions...

  11. 48 CFR 6.205 - Set-asides for HUBZone small business concerns.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Set-asides for HUBZone... 6.205 Set-asides for HUBZone small business concerns. (a) To fulfill the statutory requirements... (see 19.1302) may set aside solicitations to allow only qualified HUBZone small business concerns...

  12. 48 CFR 31.205-25 - Manufacturing and production engineering costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Manufacturing and... Commercial Organizations 31.205-25 Manufacturing and production engineering costs. (a) The costs of manufacturing and production engineering effort as described in (1) through (4) below are all allowable:...

  13. 12 CFR 205.15 - Electronic fund transfer of government benefits.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Electronic fund transfer of government benefits... RESERVE SYSTEM ELECTRONIC FUND TRANSFERS (REGULATION E) § 205.15 Electronic fund transfer of government... consumer for use in initiating an electronic fund transfer of government benefits from an account,...

  14. 40 CFR 205.163 - Recall of noncomplying motorcycles; relabeling of mislabeled motorcycles.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recall of noncomplying motorcycles... Motorcycles § 205.163 Recall of noncomplying motorcycles; relabeling of mislabeled motorcycles. (a) Pursuant to section 11(d)(1) of the Act, the Administrator may issue an order to the manufacturer to...

  15. Presentations and outcome analysis of 205 adult patients with Henoch-Schnlein purpura nephritis

    Institute of Scientific and Technical Information of China (English)

    宣萍

    2014-01-01

    Objective To analyze the clinical,pathological data and outcomes of the adult patients with HenochSchnlein purpura nephritis(HSPN).Methods The data of 205 HSPN patients who were diagnosed in Kidney Disease Center of the First Affiliated Hospital of Zhejiang University betwee Jan 2004 and May 2013 were collected and analyzed in different groups.Results The average

  16. 40 CFR 81.205 - Zanesville-Cambridge Intrastate Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Zanesville-Cambridge Intrastate Air... Air Quality Control Regions § 81.205 Zanesville-Cambridge Intrastate Air Quality Control Region. The Zanesville-Cambridge Intrastate Air Quality Control Region (Ohio) consists of the territorial...

  17. MicroRNA-205 downregulates mixed-lineage-AF4 oncogene expression in acute lymphoblastic leukemia

    Directory of Open Access Journals (Sweden)

    Dou L

    2013-08-01

    Full Text Available Liping Dou,1,* Jingxin Li,1,* Dehua Zheng,2,* Yonghui Li,1 Xiaoning Gao,1 Chengwang Xu,1 Li Gao,1 Lili Wang,1 Li Yu1 1Department of Hematology, Chinese PLA General Hospital, Beijing, People's Republic of China; 2Department of Hepatobiliary Surgery, Organ Transplant Center, Chinese PLA 309th Hospital, Beijing, People's Republic of China*These authors contributed equally to this workAbstract: Myeloid/lymphoid or mixed-lineage AF4 acute lymphoblastic leukemia (MLL-AF4 ALL is a pediatric leukemia that occurs rarely in adults. MLL-AF4 ALL is typically characterized by the presence of chromosomal translocation (t(4;11(q21;q23, leading to expression of MLL-AF4 fusion protein. Although MLL-AF4 fusion protein triggers a molecular pathogenesis and hematological presentations that are unique to leukemias, the precise role of this oncogene in leukemogenesis remains unclear. Previous studies have indicated that microRNAs (miRs might modulate the expression of MLL-AF4 ALL fusion protein, thereby suggesting the involvement of miR in progression or suppression of MLL-AF4 ALL. We have previously demonstrated that miR-205 negatively regulates transcription of an MLL-AF4 luciferase reporter. Here, we report that exogenous expression of miR-205 in MLL-AF4 human cell lines (RS4;11 and MV4-11 inversely regulates the expression of MLL-AF4 at both messenger RNA (mRNA and protein level. Furthermore, miR-205 significantly induced apoptosis in MLL-AF4 cells as evidenced by Annexin V staining using fluorescence-activated cell sorting (FACS analysis. The proliferative capacity of leukemic cells was suppressed by miR-205. The addition of an miR-205 inhibitor was able to restore the observed effects. In conclusion, these findings demonstrate that miR-205 may have potential value as a novel therapeutic agent in the treatment of MLL-AF4 ALL.Keywords: miR-205, MLL-AF4, leukemia, microRNA, oncogene expression, untranslated regions, proliferation

  18. The potential role of NGC 205 in generating Andromeda's vast thin corotating plane of satellite galaxies

    Science.gov (United States)

    Angus, Garry W.; Coppin, Paul; Gentile, Gianfranco; Diaferio, Antonaldo

    2016-11-01

    The Andromeda galaxy is observed to have a system of two large dwarf ellipticals and ˜13 smaller satellite galaxies that are currently corotating in a thin plane, in addition to 2 counter-rotating satellite galaxies. We explored the consistency of those observations with a scenario where the majority of the corotating satellite galaxies originated from a subhalo group, where NGC 205 was the host and the satellite galaxies occupied dark matter sub-subhaloes. We ran N-body simulations of a close encounter between NGC 205 and M31. In the simulations, NGC 205 was surrounded by massless particles to statistically sample the distribution of the sub-subhaloes expected in a subhalo that has a mass similar to NGC 205. We made Monte Carlo samplings and found that, using a set of reference parameters, the probability of producing a thinner distribution of sub-subhaloes than the observed NGC 205 + 15 smaller satellites (thus including the two counter-rotators, but excluding M32) increased from <10-8 for the initial distribution to ˜10-2 at pericentre. The probability of the simulated sub-subhaloes occupying the locations of the observed corotating satellites in the line-of-sight velocity versus projected on-sky distance plane is at most 2 × 10-3 for 11 out of 13 satellites. Increasing the mass of M31 and the extent of the initial distribution of sub-subhaloes gives a maximum probability of 4 × 10-3 for all 13 corotating satellites, but the probability of producing the thinness would drop to ˜10-3.

  19. Effect of excitation current intensity on mechanical properties of ZL205A castings solidified under a traveling magnetic field

    OpenAIRE

    Xue-yi Fan; Liang Wang; Zhi-qiang Du

    2015-01-01

    The effect of excitation current intensity on the mechanical properties of ZL205A castings solidified under a traveling magnetic field was studied. The results of the experiment indicate that the excitation current intensity of the traveling magnetic field has a great influence on the mechanical properties of the ZL205A castings. When the excitation current intensity is 15 A, the tensile strength and elongation of ZL205A alloy castings increase 27.2% and 67.7%, respectively, compared with tho...

  20. 20 CFR 666.205 - What are the time frames under which States submit performance progress reports and apply for...

    Science.gov (United States)

    2010-04-01

    ... I OF THE WORKFORCE INVESTMENT ACT Incentives and Sanctions for State Performance § 666.205 What are... grants, in accordance with the criteria of § 666.230. We will publish the award amounts for each...

  1. Structure correlation of Co_(79.5)Sn_(20.5) eutectic alloy between liquid and solid states

    Institute of Scientific and Technical Information of China (English)

    SUN JianJun; ZHENG HongLiang; SHI XinYing; TIAN XueLei

    2009-01-01

    The liquid structure of Co_(79.5)Sn(20.5)eutectic alloy has been investigated by means of X-ray diffraction.The result shows that the liquid structure of Co_(79.5)Sn_(20.5)alloy displays quite stable from 1350℃ to 1150℃ although the short-range order increases with temperature decreasing.In addition,the correlation between the liquid structure and solid structure also has been analyzed by "the nanocrystal model".It is shown that the melt of Co_(79.5)Sn_(20.5)alloy consists of βCo_3Sn_2 clusters and βCo clusters,indicating that the liquid structure and solid structure of Co_(79.5)Sn_(20.5)eutectic alloy are strikingly similar.

  2. Structure correlation of Co79.5Sn20.5 eutectic alloy between liquid and solid states

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The liquid structure of Co79.5Sn20.5 eutectic alloy has been investigated by means of X-ray diffraction. The result shows that the liquid structure of Co79.5Sn20.5 alloy displays quite stable from 1350℃ to 1150℃ although the short-range order increases with temperature decreasing.In addition,the correlation between the liquid structure and solid structure also has been analyzed by"the nanocrystal model".It is shown that the melt of Co79.5Sn20.5 alloy consists ofβCo3Sn2 clusters andβCo clusters, indicating that the liquid structure and solid structure of Co79.5Sn20.5 eutectic alloy are strikingly similar.

  3. 7 CFR 3015.205 - General provisions for grants and cooperative agreements with institutions of higher education...

    Science.gov (United States)

    2010-01-01

    ... agreements with institutions of higher education, other nonprofit organizations, and hospitals. 3015.205... General provisions for grants and cooperative agreements with institutions of higher education, other... higher education, other nonprofit organizations and hospitals that the recipient assure and...

  4. Comparative performance evaluation of two supercomputers: CDC Cyber-205 and CRI Cray-1

    Science.gov (United States)

    Bucher, I. Y.; Moore, J. W.

    This report compares the performance of Control Data Corporation's newest supercomputer, the Cyber-205, with the Cray Research, Inc. Cray-1, currently the Laboratory's largest main-frame. The rationale of our benchmarking effort is discussed. Results are presented of tests to determine the speed of basic arithmetic operations, of runs using our standard benchmark programs, and of runs using three codes that have been optimized for both machines; a linear system solver, a model hydrodynamics code, and parts of a plasma simulation code. It is concluded that the speed of the Cyber-205 for memory-to-memory operations on vectors stored in consecutive locations is considerably faster than that of the Cray-1. However, the overall performance of the machine is not quite equal to that of the Cray for tasks of interest to the Laboratory as represented by our benchmark set.

  5. miR-24 and miR-205 expression is dependent on HPV onco-protein expression in keratinocytes

    Energy Technology Data Exchange (ETDEWEB)

    McKenna, Declan J., E-mail: dj.mckenna@ulster.ac.uk [Biomedical Sciences Research Institute, University of Ulster, Coleraine, Co. Derry BT52 1SA (United Kingdom); Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen' s University Belfast, Belfast BT9 7BL (United Kingdom); Patel, Daksha, E-mail: d.patel@qub.ac.uk [Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen' s University Belfast, Belfast BT9 7BL (United Kingdom); McCance, Dennis J., E-mail: d.mccance@qub.ac.uk [Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen' s University Belfast, Belfast BT9 7BL (United Kingdom)

    2014-01-05

    A screen of microRNA (miRNA) expression following differentiation in human foreskin keratinocytes (HFKs) identified changes in several miRNAs, including miR-24 and miR-205. We investigated how expression of Human Papilloma Virus Type-16 (HPV16) onco-proteins E6 and E7 affected expression of miR-24 and miR-205 during proliferation and differentiation of HFKs. We show that the induction of both miR-24 and miR-205 observed during differentiation of HFKs is lost in HFKs expressing E6 and E7. We demonstrate that the effect on miR-205 is due to E7 activity, as miR-205 expression is dependent on pRb expression. Finally, we provide evidence that miR-24 effects in the cell may be due to targeting of cyclin dependent kinase inhibitor p27. In summary, these results indicate that expression of both miR-24 and miR-205 are impacted by E6 and/or E7 expression, which may be one mechanism by which HPV onco-proteins can disrupt the balance between proliferation and differentiation in keratinocytes. - Highlights: • miR-24 and miR-205 are induced during keratinocyte differentiation. • This induction is lost in keratinocytes expressing HPV onco-proteins E6 and E7. • miR-205 is dependent upon pRb expression. • miR-24 targets p27 in cycling keratinocytes.

  6. Compact, CO2-stabilized tuneable laser at 2.05 microns

    CERN Document Server

    Westergaard, Philip G; Henriksen, Martin R; Michieletto, Mattia; Triches, Marco; Lyngsø, Jens K; Hald, Jan

    2016-01-01

    We demonstrate a compact fibre-based laser system at 2.05 microns stabilized to a CO2 transition using frequency modulation spectroscopy of a gas-filled hollow-core fibre. The laser exhibits an absolute frequency accuracy of 5 MHz, a frequency stability noise floor of better than 7 kHz or 5e-11 and is tunable within +/-200 MHz from the molecular resonance frequency while retaining roughly this stability and accuracy.

  7. ALMA observations of the T Tauri binary system AS 205: evidence for molecular winds and/or binary interactions

    International Nuclear Information System (INIS)

    In this study, we present high-resolution millimeter observations of the dust and gas disk of the T Tauri star AS 205 N and its companion, AS 205 S, obtained with the Atacama Large Millimeter Array. The gas disk around AS 205 N, for which infrared emission spectroscopy demonstrates significant deviations from Keplerian motion that has been interpreted as evidence for a disk wind, also displays significant deviations from Keplerian disk emission in the observations presented here. Detections near both AS 205 N and S are obtained in 1.3 mm continuum, 12CO 2-1, 13CO 2-1, and C18O 2-1. The 12CO emission is extended up to ∼2'' from AS 205 N, and both 12CO and 13CO display deviations from Keplerian rotation at all angular scales. Two possible explanations for these observations hold up best to close scrutiny—tidal interaction with AS 205 S or disk winds (or a combination of the two)—and we discuss these possibilities in some detail.

  8. Comparison and characterization of biosorption by Weissella viridescens MYU 205 of periodic group 12 metal ions.

    Science.gov (United States)

    Kinoshita, Hideki; Ohtake, Fumika; Ariga, Yuuki; Kimura, Kazuhiko

    2016-02-01

    Because heavy metals cause various health hazards, we studied biosorption by Weissella viridescens MYU 205. MYU 205 showed high biosorption for Cd (II) and Hg (II) and was low for Zn (II). The Hg (II) biosorption rate was high at about 80%. Different biosorptions were shown for each metal after successive incubation. About 20% of the Zn (II) biosorption was observed after 3 h. Cd (II) biosorption increased in a time-dependent manner until 3 h, then gradually decreased. Hg (II) was immediately sorbed at 79.6 ± 4.7% and decreased at 3 h to 52.9 ± 2.6%, and then gradually increased to 77.8 ± 3.6%. Using heat-killed cells, the rate of biosorption of Zn (II) and Cd (II) decreased whereas Hg (II) tended to increase. The metal resistance was high, that is Zn (II) > Cd (II) > Hg (II); while the affinity was opposite where MYU 205 showed high affinity to Hg (II) and low affinity to Zn (II). Our data shows lactic acid bacteria may be powerful heavy metal sorbents for detoxification. PMID:26223952

  9. Herschel and JCMT observations of the early-type dwarf galaxy NGC 205

    CERN Document Server

    De Looze, I; Parkin, T J; Wilson, C D; Bendo, G J; Boquien, M; Boselli, A; Cooray, A; Cormier, D; Fritz, J; Galliano, F; Gear, W; Gentile, G; Lebouteillier, V; Madden, S C; Roussel, H; Sauvage, M; Smith, M W L; Spinoglio, L; Verstappen, J; Young, L

    2012-01-01

    We present Herschel dust continuum, James Clerk Maxwell Telescope CO(3-2) observations and a search for [CII] 158 micron and [OI] 63 micron spectral line emission for the brightest early-type dwarf satellite of Andromeda, NGC 205. While direct gas measurements (Mgas ~ 1.5e+6 Msun, HI + CO(1-0)) have proven to be inconsistent with theoretical predictions of the current gas reservoir in NGC 205 (> 1e+7 Msun), we revise the missing interstellar medium mass problem based on new gas mass estimates (CO(3-2), [CII], [OI]) and indirect measurements of the interstellar medium content through dust continuum emission. Based on Herschel observations, covering a wide wavelength range from 70 to 500 micron, we are able to probe the entire dust content in NGC 205 (Mdust ~ 1.1-1.8e+4 Msun at Tdust ~ 18-22 K) and rule out the presence of a massive cold dust component (Mdust ~ 5e+5 Msun, Tdust ~ 12 K), which was suggested based on millimeter observations from the inner 18.4 arcsec. Assuming a reasonable gas-to-dust ratio of ~ ...

  10. Research on reasons of unmatched blood cross matching test in 205 cases%205例交叉配血试验主侧不相合原因的研究

    Institute of Scientific and Technical Information of China (English)

    陈秉宇; 沈健; 谢一唯

    2013-01-01

    目的:探讨205例交叉配血试验主侧不相合的原因,为临床解决疑难配血提供参考。方法用盐水法、凝聚胺法和微柱凝胶法进行交叉配血等实验,并对其中交叉配血试验主侧不相合的标本和原因进行检测和分析。结果交叉配血试验主侧阳性205例,有自身抗体为21.46%(44/205),仅有自身抗体为15.61%(32/205);有同种抗体为76.59%(157/205),仅有同种抗体为70.73%(145/205);自身抗体合并同种抗体为5.85%(12/205);其他原因引起为7.80%(16/205),其中高粘滞血症引起的为2.44%(5/205),献血员直接抗球蛋白试验强阳性引起为1.46%(3/205),不明原因引起的为5.37%(11/205)。157例含血型系统抗体,其中29例因血型抗体的特异性无法鉴定,未能确定血型系统,占18.47%(29/157),128例血型系统抗体涉及ABO、Rh、MNSs、Lewis、Duffy、Kidd 6个血型系统,其中Rh血型系统抗体占血型系统抗体的75.16%(118/157),Rh血型系统抗体又以抗-E和抗-c为主,分别为85.59%(101/118)、24.58%(29/118)。结论交叉配血试验主侧不合的主要原因是不规则抗体和自身抗体,其中血型系统抗体以Rh血型系统抗体为主,特别是抗-E抗体和抗-c抗体。%Objective To evaluate the reasons of 205 cases of unmatched blood cross matching test, to solve the prob-lems of difficult blood matching. Methods Using saline method, polybrene method and micro column gel method for blood cross matching test, to detect and analyze the causes of unmatched major part of blood cross matching test. Results Major part of blood cross matching test was positive in 205 cases, among them, with the autoantibodies was 21.46%(44/205), only the autoantibodies was 15.61%(32/205); with the alloantibody was 76.59%(157/205), only the alloanti-body was 70.73%(145/205);autoantibodies associated with the alloantibody was 5.85%(12/205);other causes was 7.80%(16/205

  11. Effects of abrogating expression of miR-205 on proliferation and migration of endometrial carcinoma Ishikawa cells and its mechanism%下调microRNA-205表达对人子宫内膜癌Ishikawa细胞增殖和侵袭的作用

    Institute of Scientific and Technical Information of China (English)

    苏宁; 陈一飞; 严沁; 万小平

    2012-01-01

    目的:探讨下调microRNA-205(miR-205)表达对人子宫内膜样腺癌细胞系Ishikawa增殖和侵袭的作用及可能的机制.方法:将miR-205抑制剂(miR-205 inhibitor)瞬时转染Ishikawa细胞,下调miR-205的表达;应用实时荧光定量PCR方法(qRT-PCR)检测miR-205的表达;噻唑蓝(MTT)法检测细胞增殖能力;Transwell小室法检测细胞侵袭能力.qRT-PCR和Western blot分别检测miR-205的预测靶基因ESRRG mRNA和蛋白表达水平.应用双荧光素酶分析方法鉴定miR-205和ESRRG 3UTR的表达调节关系.结果:miR-205在Ishikawa细胞中呈高表达;转染miR-205 inhibitor的Ishikawa细胞中,miR-205表达降低了86.9%,细胞增殖和侵袭能力下降,同时细胞ESRRG mRNA和蛋白表达升高;miR-205通过直接与ESRRG mRNA 3UTR结合负调节其表达.结论:下调miR-205表达可抑制Ishikawa细胞增殖、侵袭能力;miR-205的生物效应可能与调节潜在抑癌基因ESRRG有关.%Objective:To investigate the effects of down-regulated expression of hsa-miR-205 on the proliferation and migration of Ishikawa cells and its mechanism- Methods: miR-205 inhibitor was transiently transfected into Ishikawa cells to down-regulate expression of miR-205. The expression of miR-205 was detected using quantitative reverse transcription polymerase chain reaction (qRT-PCR). Cellular proliferation and migration abilities were analyzed by 3-(4,5-dimethylthi-azol -2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay and transwell migration assay,respectively. qRT-PCR and Western blot were used to detect estrogen-related receptor gamma (ESRRG) mR-NA and protein expression,respectively,which was a putative target gene of miR-205. Luciferase assays were used to confirm the interaction between miR-205 and ESRRG, Results; miR-205 was expressed at higher levels in Ishikawa cells compared to 293T cells with a low level of miR-205. The miR-205 expression in miR-205 inhibitors transfected cells decreased 86.9%. The celluar

  12. The potential role of NGC 205 in generating Andromeda's vast thin co-rotating plane of satellite galaxies

    CERN Document Server

    Angus, Garry W; Gentile, Gianfranco; Diaferio, Antonaldo

    2016-01-01

    The Andromeda galaxy is observed to have a system of two large dwarf ellipticals and ~13 smaller satellite galaxies that are currently co-rotating in a thin plane, in addition to 2 counter-rotating satellite galaxies. We explored the consistency of those observations with a scenario where the majority of the co-rotating satellite galaxies originated from a subhalo group, where NGC 205 was the host and the satellite galaxies occupied dark matter sub-subhalos. We ran N-body simulations of a close encounter between NGC 205 and M31. In the simulations, NGC 205 was surrounded by massless particles to statistically sample the distribution of the sub-subhalos expected in a subhalo that has a mass similar to NGC 205. We made Monte Carlo samplings and found that, using a set of reference parameters, the probability of producing a thinner distribution of sub-subhalos than the observed NGC 205 + 15 smaller satellites (thus including the 2 counter-rotators, but excluding M32) increased from <1e-8 for the initial distr...

  13. Babcock and Wilcox Safety Anaysis Report (B-SAR-205). Volume 1

    International Nuclear Information System (INIS)

    The design of the BW-205 standard reactor with a plant output of 1295 and 1200 MW(e) is described. The reactor is arranged in two closed coolant loops connected in parallel to the reactor vessel, and is controlled by a coordinated combination of chemical shim and mechanical control rods. The coolant serves as a neutron moderator, reflector, and solvent for the soluble boron used in chemical shim reactivity control. The fuel elements consist of slightly enriched UO2 pellets enclosed in zircaloy tubes

  14. Formation law and criterion of nebulous macroscopic segregation in ZL205A alloy castings

    Institute of Scientific and Technical Information of China (English)

    Li Yusheng; Zhai Hu; Feng Zhijun; Qu Xuahui

    2008-01-01

    The appearance of macroscopic segregation in ZL205A alloy castings bears a super resemblance to the appearance of shrinkage porosity, and the chemical composition of the segregation is Al2Cu whose microstructure is in the form of dentrite or skeleton crystal. According to the characteristic of nebulous segregation, the formation process could be divided into two steps by the eutectic temperature of Al2Cu. Then a criterion for each of the two steps is brought forward on the basis of the shrinkage porosity criterion of low pressure casting.

  15. Analysis of miR-205 and miR-155 expression in the blood of breast cancer patients

    Institute of Scientific and Technical Information of China (English)

    Jingjing Liu; Qixin Mao; Yan Liu; Xiaomeng Hao; Sheng Zhang; Jin Zhang

    2013-01-01

    The purpose of this study was to identify and validate circulating microRNAs (miRNAs) in human plasma for use as breast cancer (BC) biomarkers and to analyze their relationship to clinicopathologic features and its preliminary biological function.Genome-wide expression profiling of miRNAs in BC was investigated by microarray analysis.nmiR-155 was up-regulated greater than two-fold in BC compared with Normal Adjacent Tissue (NAT),whereas let-7b,miR-381,miR-10b,miR-125a-Sp,miR-335,miR-205 and miR-145 were down-regulated greater than two-fold.Our hypothesis was that circulating miRNAs are also present and differentially expressed in the serum of BC patients compared to controls.Using real-time PCR (RT-PCR),we analyzed miR-205 and miR-155 in archived serum from 30 participants,20 with breast cancer and 10 healthy people.miR-205 was down-regulated in BC patient serum while miR-155 was up-regulated.Furthermore,we analyzed the relationship between the expression levels of these two miRNAs and the clinicopathologic parameters of BC patients.High expression of miR155 was associated with clinical stage,molecular type,Ki-67 and p53 in BC patients (P<0.05).By contrast,we found no significant correlation between miR-205 and BC patient clinicopathologic parameters.Functional analysis showed that ectopic expression of miR-205 significantly inhibits cell proliferation and promotes apoptosis.miR-205 was down-regulated and miR-155 was up-regulated in BC patient serum.miR-155 was positive correlated with clinical stage and ki-67 and negatively correlated with p53 status.

  16. A Novel Wind Profiler Radar at 205 MHz: Technical aspects and Validation

    Science.gov (United States)

    Kottayil, Ajil; Mohanakumar, Kesavapillai

    2016-07-01

    An experimental wind profiler radar operating at 205 MHz has been set up for the first time in the World in the near equatorial region at Cochin (10.04 degree N; 76.33 degree E), India. Here we present a system description and first time validation of this radar. This profiler constitutes 49, three element Yagi-Uda antennae with an effective aperture area of 42 m2. Doppler Beam Swinging method is used for measuring the three dimensional wind components. The radar wind profiles have been validated against collocated GPS- radiosonde measurements for the altitude range of 1-6 km. The validation shows a very good agreement between radar and radiosonde wind measurements both in terms of magnitude and direction, with an observed correlation of 0.91 and 0.85, for zonal and meridional winds, respectively. The standard deviation of the difference between radiosonde and radar for zonal wind is found to be 1.95 m/s and 1.56 m/s for meridional wind. The radar has been set up as a predecessor to a bigger radar bearing 619 antennae with an aim of studying the regional monsoon characteristics. The results show that the 205 MHz Wind Profiler is capable of providing high quality wind data which can boost studies on the Indian summer monsoon.

  17. Sh2-205: Three independent HII regions or only one?

    Science.gov (United States)

    Romero, G. A.; Cappa, C. E.

    Resumen: We present a study of the HII region Sh2-205 and its environs, based on data obtained from the CGPS, 12CO observations and MSX. We find that Sh2-205 can be separated in three independent optical structures: SH149.25-0.0, SH148.83-0.67, and LBN148.11-0.45. The derived spectral indices show the thermal nature of SH148.83-0.67 and LBN148.11-0.45. The morphology of SH148.83-0.67, both in optical and in radio, along with the energetic requirements indicate that this feature is an interstellar bubble powered by the UV photons of HD24431 (O9 III). LBN148.11-0.45 has the morphology of a classical HII region and their ionizing sources remain uncertain. Dust and molecular gas are found related to LBN148.11-0.45. Particularly, a photodissociation region is detected surrounding the central part of this HII region at infrared wavelengths.

  18. Element segregation behavior of aluminum-copper alloy ZL205A

    Institute of Scientific and Technical Information of China (English)

    Fan Li; Hao Qitang; Xian Fuchao

    2014-01-01

    In aluminum-copper al oy, the segregation has a severe bad effect on the al oying degree, strength and corrosion resistance. A deeper understanding of element segregation behavior wil have a great significance on the prevention of segregation. In the study, the element segregation behavior of ZL205A aluminum-copper al oy was investigated by examining isothermal y solidified samples using scanning electron microscopy and energy dispersive spectroscopy. The calculated results of segregation coefficients show that Cu and Mn are negative segregation elements; while Ti, V and Zr are positive segregation elements. The sequence of element segregation degree from the greatest to the least in ZL205A al oy is Cu, Mn, V, Ti, Zr and Al. The density of residual liquid is expected to increase with a decrease in the quenching temperature ranging from 630 ºC to 550 ºC. The calculated results confirm that the quenching temperature has an insignificant effect on the liquid density;and the variation of density is mainly due to element segregation. Consequently, segregations of Al, Cu and Mn lead to an increase in density, but Ti, V and Zr present the opposite effect. The contribution of each element to the variation of the liquid density was analyzed. The sequence of contributions of al oying elements to the variation of total liquid density is Cu﹥Al﹥Mn﹥V﹥Ti﹥Zr.

  19. Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.

    Science.gov (United States)

    Kachaner, David; Pinson, Xavier; El Kadhi, Khaled Ben; Normandin, Karine; Talje, Lama; Lavoie, Hugo; Lépine, Guillaume; Carréno, Sébastien; Kwok, Benjamin H; Hickson, Gilles R; Archambault, Vincent

    2014-10-27

    Drosophila melanogaster Polo and its human orthologue Polo-like kinase 1 fulfill essential roles during cell division. Members of the Polo-like kinase (Plk) family contain an N-terminal kinase domain (KD) and a C-terminal Polo-Box domain (PBD), which mediates protein interactions. How Plks are regulated in cytokinesis is poorly understood. Here we show that phosphorylation of Polo by Aurora B is required for cytokinesis. This phosphorylation in the activation loop of the KD promotes the dissociation of Polo from the PBD-bound microtubule-associated protein Map205, which acts as an allosteric inhibitor of Polo kinase activity. This mechanism allows the release of active Polo from microtubules of the central spindle and its recruitment to the site of cytokinesis. Failure in Polo phosphorylation results in both early and late cytokinesis defects. Importantly, the antagonistic regulation of Polo by Aurora B and Map205 in cytokinesis reveals that interdomain allosteric mechanisms can play important roles in controlling the cellular functions of Plks.

  20. The Ionized Gas in Nearby Galaxies as Traced by the [N II] 122 and 205 μm Transitions

    OpenAIRE

    Herrera-Camus, R.; Bolatto, A.; Smith, J. D.; Draine, B.; Pellegrini, E.; Wolfire, M.; Croxall, K.; De Looze, I.; Calzetti, D.; Kennicutt, R.; Crocker, A.; Armus, L.; van der Werf, P.; Sandstrom, K.; Galametz, M.

    2016-01-01

    The [N ii] 122 and 205 μm transitions are powerful tracers of the ionized gas in the interstellar medium. By combining data from 21 galaxies selected from the Herschel KINGFISH and Beyond the Peak surveys, we have compiled 141 spatially resolved regions with a typical size of ~1 kpc, with observations of both [N ii] far-infrared lines. We measure [N ii] 122/205 line ratios in the ~0.6–6 range, which corresponds to electron gas densities of n_e ~ 1–300 cm^(−3), with a median value of n_e = 30 ...

  1. Electrochemical hydrogen storage properties of La0.95Mg2.05Ni9 alloy prepared by mechanical alloying

    Institute of Scientific and Technical Information of China (English)

    蒙冕武; 刘心宇; 成钧; 周怀营

    2004-01-01

    The structure, microstructure, thermal stability and hydriding characteristics of amorphous La0.95-Mg2.05 Ni9 have been investigated with differential thermal analysis, X-ray diffraction, scanning electron microscopy and battery test. It is found that the increase in mechanical alloying time leads to enhancement in thermal stabilities of amorphous La0. 95 Mg2.05 Ni9 alloy. The amorphous alloy has good charge/discharge ability at room temperature (430 mA · h · g-1 ), but the discharge capacity decreases seriously during cycling tests due to the crystallization of amorphous and oxidization of magnesium on the particle surface in alkaline aqueous solution.

  2. MAST205 competes with cystic fibrosis transmembrane conductance regulator (CFTR)-associated ligand for binding to CFTR to regulate CFTR-mediated fluid transport.

    Science.gov (United States)

    Ren, Aixia; Zhang, Weiqiang; Yarlagadda, Sunitha; Sinha, Chandrima; Arora, Kavisha; Moon, Chang-Suk; Naren, Anjaparavanda P

    2013-04-26

    The PDZ (postsynaptic density-95/discs large/zona occludens-1) domain-based interactions play important roles in regulating the expression and function of the cystic fibrosis transmembrane conductance regulator (CFTR). Several PDZ domain-containing proteins (PDZ proteins for short) have been identified as directly or indirectly interacting with the C terminus of CFTR. To better understand the regulation of CFTR processing, we conducted a genetic screen and identified MAST205 (a microtubule-associated serine/threonine kinase with a molecular mass of 205 kDa) as a new CFTR regulator. We found that overexpression of MAST205 increased the expression of CFTR and augmented CFTR-mediated fluid transport in a dose-dependent manner. Conversely, knockdown of MAST205 inhibited CFTR function. The PDZ motif of CFTR is required for the regulatory role of MAST205 in CFTR expression and function. We further demonstrated that MAST205 and the CFTR-associated ligand competed for binding to CFTR, which facilitated the processing of CFTR and consequently up-regulated the expression and function of CFTR at the plasma membrane. More importantly, we found that MAST205 could facilitate the processing of F508del-CFTR mutant and augment its quantity and channel function at the plasma membrane. Taken together, our data suggest that MAST205 plays an important role in regulating CFTR expression and function. Our findings have important clinical implications for treating CFTR-associated diseases such as cystic fibrosis and secretory diarrheas.

  3. 41 CFR 102-33.205 - When we use our aircraft to support other executive agencies, must we recover the operating costs?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false When we use our aircraft to support other executive agencies, must we recover the operating costs? 102-33.205 Section 102-33... Aircraft and Aircraft Parts Accounting for the Cost of Government Aircraft § 102-33.205 When we use...

  4. Complete Genome Sequence of Bacillus velezensis CBMB205, a Phosphate-Solubilizing Bacterium Isolated from the Rhizoplane of Rice in the Republic of Korea

    Science.gov (United States)

    Hwangbo, Kyeong; Um, Yurry; Kim, Ki Yoon; Madhaiyan, Munusamy; Sa, Tong Min

    2016-01-01

    Bacillus velezensis CBMB205 (= KACC 13105T = NCCB 100236T) was isolated from the rhizoplane of rice (Oryza sativa L. cv. O-dae). According to previous studies, this bacterium has several genes that can promote plant growth, such as the phosphorus-solubilizing protein-coding gene. Here, we present the first complete genome of B. velezensis CBMB205. PMID:27417835

  5. 17 CFR 275.205-2 - Definition of “specified period” over which the asset value of the company or fund under...

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Definition of âspecified periodâ over which the asset value of the company or fund under management is averaged. 275.205-2 Section... REGULATIONS, INVESTMENT ADVISERS ACT OF 1940 § 275.205-2 Definition of “specified period” over which the...

  6. A Herschel Survey of the [N II] 205 micron Line in Local Luminous Infrared Galaxies --- The [N II] 205 micron Emission as a Star Formation Rate Indicator

    CERN Document Server

    Zhao, Yinghe; Xu, C Kevin; Gao, Yu; Lord, S; Howell, J; Isaak, K G; Charmandaris, V; Diaz-Santos, T; Appleton, P; Evans, A; Iwasawa, K; Leech, J; Mazzarella, J; Petric, A O; Sanders, D B; Schulz, B; Surace, J; van der Werf, P P

    2013-01-01

    We present, for the first time, a statistical study of [N II] 205 mciron line emission for a large sample of local luminous infrared galaxies using Herschel Spectral and Photometric Imaging Receiver Fourier Transform Spectrometer (SPIRE FTS) data. For our sample of galaxies, we investigate the correlation between the [N II] luminosity (LNII) and the total infrared luminosity (LIR), as well as the dependence of LNII/LIR ratio on LIR, far infrared colors (IRAS $f_{60}/f_{100}$) and the [O III] 88 micron to [N II] luminosity ratio. We find that LNII correlates almost linearly with LIR for non AGN galaxies (all having $L_{IR} < 10^{12} L_solar$) in our sample, which implies that LNII can serve as a SFR tracer which is particularly useful for high redshift galaxies which will be observed with forthcoming submm spectroscopic facilities such as the Atacama Large Millimeter/submillimeter Array. Our analysis shows that the deviation from the mean LNII-LIR relation correlates with tracers of the ionization parameter...

  7. 205 cases of endoscopic hemostasis to treat epistaxis by using an electrocoagulation device with suction%鼻内镜下用带吸引电凝器治疗鼻出血205例临床分析

    Institute of Scientific and Technical Information of China (English)

    金玲; 车娜; 张宇; 张晓林; 常永军; 葛荣明

    2013-01-01

    Objective o discuss the method of endoscopic electrocoagulation in the treatment of epistaxis.Methods Retrospectively analysis 205 cases of intraoperative treatment of epistaxis by using an electrocoagulation device with suction in our department.Results Of the 205 cases,a cases stopped bleeding after surgery,during 3-month follow up,6 case showed rebleeding,while 199 show no recurrent epistaxis.Conclusion The advantages of using an electrocoagulation device with suction during endoscopic intraoperative treatment of epistaxis include clear field of view,correct operation scope,and less painful.%目的:探讨鼻内镜下电凝止血的方法。方法回顾性分析我科在鼻内镜下用带吸引的电凝器治疗205例鼻出血患者临床资料。结果205例中,199例一次性治愈,随访3月内再次鼻出血的6例。结论在鼻内镜下用带吸引的电凝器止血,视野清晰,止血准确,病人痛苦小,效果良好。

  8. Cytocompatibility of direct water synthesized cadmium selenide quantum dots in colo-205 cells

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez-Torres, Marcos R. [Universidad Metropolitana, Nanomaterials Science Laboratory, School of Science and Technology (United States); Velez, Christian; Zayas, Beatriz [Universidad Metropolitana, ChemTox Laboratory, School of Environmental Affairs (United States); Rivera, Osvaldo [Universidad Metropolitana, Nanomaterials Science Laboratory, School of Science and Technology (United States); Arslan, Zikri [Jackson State University, Department of Chemistry (United States); Gonzalez-Vega, Maxine N. [Universidad Metropolitana, Nanomaterials Science Laboratory, School of Science and Technology (United States); Diaz-Diestra, Daysi; Beltran-Huarac, Juan; Morell, Gerardo [University of Puerto Rico, Molecular Science Research Center (United States); Primera-Pedrozo, Oliva M., E-mail: oprimera1@suagm.edu [Universidad Metropolitana, Nanomaterials Science Laboratory, School of Science and Technology (United States)

    2015-06-15

    Cadmium selenide quantum dots (CdSe QDs), inorganic semiconducting nanocrystals, are alluring increased attraction due to their highly refined chemistry, availability, and super tunable optical properties suitable for many applications in different research areas, such as photovoltaics, light-emitting devices, environmental sciences, and nanomedicine. Specifically, they are being widely used in bio-imaging in contrast to organic dyes due to their high brightness and improved photo-stability, and their ability to tune their absorption and emission spectra upon changing the crystal size. The production of CdSe QDs is mostly assisted by trioctylphosphine oxide compound, which acts as solvent or solubilizing agent and renders the QDs soluble in organic compounds (such as toluene, chloroform, and hexane) that are highly toxic. To circumvent the toxicity-related factor in CdSe QDs, we report the synthesis of CdSe QDs capped with thioglycolic acid (TGA) in an aqueous medium, and their biocompatibility in colo-205 cancer cells. In this study, the [Cd{sup 2+}]/[TGA] ratio was adjusted to 11:1 and the Se concentration (10 and 15 mM) was monitored in order to evaluate its influence on the optical properties and cytocompatibility. QDs resulted to be quite stable in water (after purification) and RPMI cell medium and no precipitation was observed for long contact times, making them appealing for in vitro experiments. The spectroscopy analysis, advanced electron microscopy, and X-ray diffractometry studies indicate that the final products were successfully formed exhibiting an improved optical response. Colo-205 cells being exposed to different concentrations of TGA-capped CdSe QDs for 12, 24, and 48 h with doses ranging from 0.5 to 2.0 mM show high tolerance reaching cell viabilities as high as 93 %. No evidence of cellular apoptotic pathways was observed as pointed out by our Annexin V assays at higher concentrations. Moreover, confocal microscopy analysis conducted to

  9. Cytocompatibility of direct water synthesized cadmium selenide quantum dots in colo-205 cells

    International Nuclear Information System (INIS)

    Cadmium selenide quantum dots (CdSe QDs), inorganic semiconducting nanocrystals, are alluring increased attraction due to their highly refined chemistry, availability, and super tunable optical properties suitable for many applications in different research areas, such as photovoltaics, light-emitting devices, environmental sciences, and nanomedicine. Specifically, they are being widely used in bio-imaging in contrast to organic dyes due to their high brightness and improved photo-stability, and their ability to tune their absorption and emission spectra upon changing the crystal size. The production of CdSe QDs is mostly assisted by trioctylphosphine oxide compound, which acts as solvent or solubilizing agent and renders the QDs soluble in organic compounds (such as toluene, chloroform, and hexane) that are highly toxic. To circumvent the toxicity-related factor in CdSe QDs, we report the synthesis of CdSe QDs capped with thioglycolic acid (TGA) in an aqueous medium, and their biocompatibility in colo-205 cancer cells. In this study, the [Cd2+]/[TGA] ratio was adjusted to 11:1 and the Se concentration (10 and 15 mM) was monitored in order to evaluate its influence on the optical properties and cytocompatibility. QDs resulted to be quite stable in water (after purification) and RPMI cell medium and no precipitation was observed for long contact times, making them appealing for in vitro experiments. The spectroscopy analysis, advanced electron microscopy, and X-ray diffractometry studies indicate that the final products were successfully formed exhibiting an improved optical response. Colo-205 cells being exposed to different concentrations of TGA-capped CdSe QDs for 12, 24, and 48 h with doses ranging from 0.5 to 2.0 mM show high tolerance reaching cell viabilities as high as 93 %. No evidence of cellular apoptotic pathways was observed as pointed out by our Annexin V assays at higher concentrations. Moreover, confocal microscopy analysis conducted to evaluate

  10. 7 CFR 205.303 - Packaged products labeled “100 percent organic” or “organic.”

    Science.gov (United States)

    2010-01-01

    ...) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Labels, Labeling, and Market Information § 205.303 Packaged products labeled “100 percent organic” or “organic.” (a) Agricultural...

  11. 34 CFR 85.205 - Why is it important if a particular transaction is a covered transaction?

    Science.gov (United States)

    2010-07-01

    ... permitted under § 85.120. Authority: E.O. 12549 (3 CFR, 1986 Comp., p. 189); E.O 12689 (3 CFR, 1989 Comp., p... 34 Education 1 2010-07-01 2010-07-01 false Why is it important if a particular transaction is a... GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Covered Transactions § 85.205 Why is it important if...

  12. 49 CFR 571.205(a) - Glazing equipment manufactured before September 1, 2006 and glazing materials used in vehicles...

    Science.gov (United States)

    2010-10-01

    ... with 49 CFR 571.205 instead of this standard. S2. Purpose. The purpose of this standard is to reduce... glazing materials used in vehicles manufactured before November 1, 2006. S1. Scope. This standard... the vehicle windows in collisions. S3. Application. This standard applies to glazing...

  13. 50 CFR 226.205 - Critical habitat for Snake River sockeye salmon, Snake River fall chinook salmon, and Snake River...

    Science.gov (United States)

    2010-10-01

    ... in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies of the USGS publication and maps may be... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Critical habitat for Snake River sockeye salmon, Snake River fall chinook salmon, and Snake River spring/summer chinook salmon. 226.205...

  14. 23 CFR 420.205 - What is the FHWA's policy for research, development, and technology transfer funding?

    Science.gov (United States)

    2010-04-01

    ... Technology Transfer Program Management § 420.205 What is the FHWA's policy for research, development, and... in this program development and technology transfer programs to share the results of their own... 23 Highways 1 2010-04-01 2010-04-01 false What is the FHWA's policy for research, development,...

  15. The anatomy of a radio source hot spot : Very large baseline array imaging of 3C 205

    NARCIS (Netherlands)

    Lonsdale, CJ; Barthel, PD

    1998-01-01

    Total intensity and linear polarization Very Long Baseline Array (VLBA) images of the high-redshift quasar 3C 205 at a wavelength of 18 cm reveal a complex curved hot-spot structure with polarization percentages frequently as high as 70%. A one-sided jet is detected emerging from the central compone

  16. Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer

    DEFF Research Database (Denmark)

    Wiklund, Erik D; Bramsen, Jesper B; Hulf, Toby;

    2011-01-01

    MicroRNAs (miRNA) are small noncoding RNAs commonly deregulated in cancer. The miR-200 family (miR-200a, -200b, -200c, -141 and -429) and miR-205 are frequently silenced in advanced cancer and have been implicated in epithelial to mesenchymal transition (EMT) and tumor invasion by targeting the t...

  17. 5 CFR 352.205b - Authority to return an SES employee to his or her former or successor agency.

    Science.gov (United States)

    2010-01-01

    ... less than the SES rate of basic pay as determined under 5 CFR part 534, subpart D at which the employee... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Authority to return an SES employee to... Between Executive Agencies During Emergencies § 352.205b Authority to return an SES employee to his or...

  18. Use of CYBER 203 and CYBER 205 computers for three-dimensional transonic flow calculations

    Science.gov (United States)

    Melson, N. D.; Keller, J. D.

    1983-04-01

    Experiences are discussed for modifying two three-dimensional transonic flow computer programs (FLO 22 and FLO 27) for use on the CDC CYBER 203 computer system. Both programs were originally written for use on serial machines. Several methods were attempted to optimize the execution of the two programs on the vector machine: leaving the program in a scalar form (i.e., serial computation) with compiler software used to optimize and vectorize the program, vectorizing parts of the existing algorithm in the program, and incorporating a vectorizable algorithm (ZEBRA I or ZEBRA II) in the program. Comparison runs of the programs were made on CDC CYBER 175. CYBER 203, and two pipe CDC CYBER 205 computer systems.

  19. Vectorizing the Monte Carlo algorithm for lattice gauge theory calculations on the CDC cyber 205

    Science.gov (United States)

    Barkai, D.; Moriarty, K. J. M.

    1982-06-01

    Lattice gauge theory is a technique for studying quantum field theory free of divergences. All the Monte Carlo computer calculations up to now have been performed on scalar machines. A technique has been developed for effectively vectorizing this class of Monte Carlo problems. The key for vectorizing is in finding groups in finding groups of points on the space-time lattice which are independent of each other. This requires a particular ordering of points along diagonals. A technique for matrix multiply is used which enables one to get the whole of the result matrix in one pass. The CDC CYBER 205 is most suitable for this class of problems using random "index-lists" (arising from the ordering algorithm and the use of random numbers) due to the hardware implementation of "GATHER" and "SCATTER" operations performing at a streaming-rate. A preliminary implementation of this method has executed 5 times faster than on the CDC 7600 system.

  20. Ultraviolet continuous-wave laser source at 205 nm for hydrogen spectroscopy

    Science.gov (United States)

    Galtier, Sandrine; Nez, François; Julien, Lucile; Biraben, François

    This paper reports on the generation of 15 mW of continuous narrow-band laser source at 205 nm. The infra-red light source provided by a Titanium-Sapphire (TiSa) laser is mixed with the fourth harmonic of a Nd:YVO4 laser by the use of a β-barium borate (BBO) non-linear crystal. This highly reliable and powerful ultraviolet (UV) source is an ideal tool for the 1S-3S hydrogen spectroscopy. Moreover, the wide tunability of the TiSa laser combined with this experimental set up makes the generation of bright deep ultra-violet (D-UV) sources possible. In particular, we plan to produce a 194 nm continuous light beam which is necessary to perform the 1S-4S transition in hydrogen.

  1. Relationship Between Net Photosynthetic Rate of Cassava SC205 and Its Physio-ecological Factors

    Institute of Scientific and Technical Information of China (English)

    Yong SONG; Xuan LIN; Jinhui YANG; Yuping DENG; Xingyao XIONG

    2014-01-01

    [Objective]The aim was to measure photosynthetic characters of SC 205, a cassava cultivar, and explore the relationships of the net photosynthetic rate (Pn) with physiological and ecological factors. [Method] The diurnal variations of photosyn-thesis in leaves of SC205 were studied by LICOR-6400 portable photosynthesis system, and the relationships of the net photosynthetic rate (Pn) with physiological and ecological factors were studied by simple correlation analysis and path analysis. [Result] The curve of diurnal variation of Pn showed single peak at 10:00 am at 24.07 μ mol CO2 m2/s, without showing midday depression; the diurnal changes of stomatal conductance (Gs), transpiration rate (Tr), leaf temperature (Tl), air tempera-ture (Ta) and photosynthetic active radiation (PAR) al showed single peak curves, and there were positive relationships of Pn with Gs, Tr, Tl, Ta and PAR. The diur-nal variations of intercellular CO2 concentration (Ci), atmospheric CO2 concentration (Ca), relative humidity (RH) showed in a U-shape curve. There were highly signifi-cant positive correlation of Pn with Gs and PAR; the diurnal variation of Pn had highly significant negative correlations with Ci and Ca. The direct impact of physio-logical factors on Pn was as fol ows: Ci>Gs>Tl>Tr, and the direct impact of ecologi-cal factors was RH>PAR>Ca>Ta. [Conclusion] The research showed that Ci, Gs and Tr play very important roles in the changes of Pn among the physiological fac-tors, and PAR and Ca affect the changes of Pn among the ecological factors.

  2. TGF-β1 regulating miR-205/miR-195 expression affects the TGF-β signal pathway by respectively targeting SMAD2/SMAD7.

    Science.gov (United States)

    Duan, Yingjun; Chen, Qianxue

    2016-10-01

    Transforming growth factor-β (TGF-β) proteins are important cytokines in the occurrence and development of tumors. However, its neural functions in glioma are still not understood. In the present study, we evaluated the effects of TGF-β1 on glioma cell line U87. miR-205 and miR-195 were involved in TGF-β1 signaling pathway. Quantitative real-time PCR was used to detect miR-205 and miR-195 levels in human glioma tissue samples and U87 cells treated with different concentrations of TGF-β1. Enzyme-linked immunosorbent assay (ELISA) was performed to determine TGF-β1 in the glioma patients peripheral blood. In vitro, U87 cells were transfected with mimics or inhibitors of miR-205 and miR-195. SMAD proteins were assayed by western blotting. Luciferase assay and co-immunoprecipitation (Co-IP)were used to determine the relationships between miR-205 and SMAD2, miR-195 and SMAD7. Effects of miR-205 and miR-195 on glioma cell proliferation and invasion using colony forming and cell migration assays. It was shown that miR-205 was decreased in glioma tissue, but miR-195 and TGF-β1 was increased. In addition, TGF-β1 concentration was negatively correlated with miR-205 mRNA level, but positively correlated with miR-195 mRNA. In addition, miR-205 was downregulated and miR-195 was upregulated by TGF-β1 in a dose-dependent manner. miR-205 and miR-195 targeted and inhibited SMAD2 and SMAD7 expression, respectively, in U87. High expression of miR-205 but not miR-195 reduced SMAD2 and SMAD4 heteromer formation. In addition, it was also shown that miR-205 overexpression inhibited U87 proliferation and invasion efficiently. All the results suggested that miR-205 and miR-195 participated in the TGF-β1 signaling pathway and showed opposite effects in glioma. These findings contribute to the understanding of TGF-β1 function in glioma.

  3. Scientific opinion of Flavouring Group Evaluation 205 Revision 1 (FGE.205Rev1): consideration of genotoxicity data on representatives for 13 α,β-unsaturated aliphatic ketones with terminal double bonds and precursors from chemical subgroup 1.2.2 of FGE.19

    DEFF Research Database (Denmark)

    Beltoft, Vibe Meister; Nørby, Karin Kristiane

    The EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) was requested to consider in the Flavouring Group Evaluation 205 (FGE.205), the additional data on genotoxicity submitted by the Industry on two representative substances, oct-1-en-3-one [FL-no: 07.081]...

  4. Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells.

    Directory of Open Access Journals (Sweden)

    Shiyo Muratsu-Ikeda

    Full Text Available BACKGROUND: Oxidative stress and endoplasmic reticulum (ER stress play a crucial role in tubular damage in both acute kidney injury (AKI and chronic kidney disease (CKD. While the pathophysiological contribution of microRNAs (miRNA to renal damage has also been highlighted, the effect of miRNA on renal damage under oxidative and ER stresses conditions remains elusive. METHODS: We assessed changes in miRNA expression in the cultured renal tubular cell line HK-2 under hypoxia-reoxygenation-induced oxidative stress or ER stress using miRNA microarray assay and real-time RT-PCR. The pathophysiological effect of miRNA was evaluated by cell survival rate, intracellular reactive oxygen species (ROS level, and anti-oxidant enzyme expression in miRNA-inhibited HK-2 or miRNA-overexpressed HK-2 under these stress conditions. The target gene of miRNA was identified by 3'-UTR-luciferase assay. RESULTS: We identified 8 and 10 miRNAs whose expression was significantly altered by oxidative and ER stresses, respectively. Among these, expression of miR-205 was markedly decreased in both stress conditions. Functional analysis revealed that decreased miR-205 led to an increase in cell susceptibility to oxidative and ER stresses, and that this increase was associated with the induction of intracellular ROS and suppression of anti-oxidant enzymes. While increased miR-205 by itself made no change in cell growth or morphology, cell viability under oxidative or ER stress conditions was partially restored. Further, miR-205 bound to the 3'-UTR of the prolyl hydroxylase 1 (PHD1/EGLN2 gene and suppressed the transcription level of EGLN2, which modulates both intracellular ROS level and ER stress state. CONCLUSIONS: miR-205 serves a protective role against both oxidative and ER stresses via the suppression of EGLN2 and subsequent decrease in intracellular ROS. miR-205 may represent a novel therapeutic target in AKI and CKD associated with oxidative or ER stress in tubules.

  5. Search for extinct natural radioactivity of Pb205 via thallium-isotope anomalies in chondrites and lunar soil.

    Science.gov (United States)

    Huey, J. M.; Kohman, T. P.

    1972-01-01

    Thallium and Pb204 contents were determined by stable-isotope-dilution analysis in 16 chondrites, one achondrite, and Apollo 11 and 12 lunar fines. Meteoritic thallium contents vary over a large range, 0.02 to 100 ppb, corresponding to the fact that thallium is a highly fractionated volatile element. Lunar thallium contents are less than 5 ppb. The Tl205/Tl203 ratio was determined in most of the samples, with precision ranging from 0.03% to several percent depending mainly on the amount of thallium present. No variations from the terrestrial ratio were observed. The chondritic isochron slope for Pb205 (13.8-m.y. half-life) is less than or equal to 0.00009 (99% confidence level), corresponding to an interval of at least 60 m.y. and possibly exceeding 120 m.y. between the termination of s-process nucleosynthesis and the lead-thallium fractionations.

  6. Cultivation and identification of colon cancer stem cell-derived spheres from the Colo205 cell line

    International Nuclear Information System (INIS)

    Our group established a method to culture spheres under serum-free culture condition. However, the biological characteristics and the tumorigenicity of spheres are unknown. Here, we demonstrate that sphere cells expressed high levels of the putative colorectal cancer stem cell markers CD133 and CD44. The CD133-positive rates were 13.27 ± 5.62, 52.71 ± 16.97 and 16.47 ± 2.45% in sphere cells, regular Colo205 cells and differentiated sphere cells, respectively, while the CD44-positive rates were 62.92 ± 8.38, 79.06 ± 12.10 and 47.80 ± 2.5%, respectively, and the CD133/CD44-double-positive rates were 10.77 ± 4.96, 46.89 ± 19.17 and 12.41 ± 2.27%, respectively (P < 0.05). Cancer sphere cells formed crypt-like structures in 3-D culture. Moreover, cells from cancer spheres exhibited more tumorigenicity than regular Colo205 cells in a xenograft assay. The cancer sphere cells displayed much higher oncogenicity than regular Colo205 cells to initiate neoplasms, as assayed by H&E staining, Musashi-1 staining and electron microscopy. Our findings indicated that the sphere cells were enriched with cancer stem cells (CSCs), and exhibited more proliferation capacity, more differentiation potential and especially more tumorigenicity than regular Colo205 cells in vitro and in vivo. Further isolation and characterization of these CSCs may provide new insights for novel therapeutic targets and prognostic markers

  7. Cuminaldehyde from Cinnamomum verum Induces Cell Death through Targeting Topoisomerase 1 and 2 in Human Colorectal Adenocarcinoma COLO 205 Cells

    OpenAIRE

    Kuen-daw Tsai; Yi-Heng Liu; Ta-Wei Chen; Shu-Mei Yang; Ho-Yiu Wong; Jonathan Cherng; Kuo-Shen Chou; Jaw-Ming Cherng

    2016-01-01

    Cinnamomum verum, also called true cinnamon tree, is employed to make the seasoning cinnamon. Furthermore, the plant has been used as a traditional Chinese herbal medication. We explored the anticancer effect of cuminaldehyde, an ingredient of the cortex of the plant, as well as the molecular biomarkers associated with carcinogenesis in human colorectal adenocarcinoma COLO 205 cells. The results show that cuminaldehyde suppressed growth and induced apoptosis, as proved by depletion of the mit...

  8. Investigation of the /sup 203/ /sup 205/Tl level schemes after (n,n'gamma) reactions at 2. 75 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Wohlfarth, H.; Kretz, R.; Backe, H.; Hegewisch, S.; Vonach, H.

    1980-06-01

    Some 259 gamma-lines have been observed with Ge(Li) detectors from (/sup 203/ /sup 205/)Tl(n,n'gamma) reactions with 2.75 MeV neutrons using (/sup nat/)Tl and enriched (/sup 203/)Tl samples. The different gamma lines could be attributed unambiguously to the (/sup 203/)Tl and (/sup 205/)Tl isotopes. It was possible to assign only 60 and 54 transitions to the known level schemes of (/sup 203/)Tl and (/sup 205/)Tl, respectively. From these facts it can be concluded that the low spin members in (/sup 203/ /sup 205/) Tl between 1.5 and 2.7 MeV are only partially known. The decay of a 5/2/sup -/ level at 2623.1 keV in (205)Tl was identified and the corresponding transition energies have been measured. With these results isomer shifts of general gamma lines corresponding to the decay of the same 5/2/sup -/ level in muonic (/sup 205/)Tl were determined.

  9. Effect of excitation current intensity on mechanical properties of ZL205A castings solidified under a traveling magnetic field

    Directory of Open Access Journals (Sweden)

    Xue-yi Fan

    2015-05-01

    Full Text Available The effect of excitation current intensity on the mechanical properties of ZL205A castings solidified under a traveling magnetic field was studied. The results of the experiment indicate that the excitation current intensity of the traveling magnetic field has a great influence on the mechanical properties of the ZL205A castings. When the excitation current intensity is 15 A, the tensile strength and elongation of ZL205A alloy castings increase 27.2% and 67.7%, respectively, compared with those of the same alloy solidified under gravity. The improvement of mechanical properties is attributed to the decrease of micro-porosity in the alloy. Under the traveling magnetic field, the feeding pressure in the alloy melt before solidification can be enhanced due to the electromagnetic force. Moreover, the melt flow induced by the traveling magnetic field can decrease the temperature gradient. The feeding resistance will be increased because the temperature gradient decrease. So traveling magnetic field has an optimum effect on feeding.

  10. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination.

    Science.gov (United States)

    Bonifaz, Laura C; Bonnyay, David P; Charalambous, Anna; Darguste, Dara I; Fujii, Shin-Ichiro; Soares, Helena; Brimnes, Marie K; Moltedo, Bruno; Moran, Thomas M; Steinman, Ralph M

    2004-03-15

    The prevention and treatment of prevalent infectious diseases and tumors should benefit from improvements in the induction of antigen-specific T cell immunity. To assess the potential of antigen targeting to dendritic cells to improve immunity, we incorporated ovalbumin protein into a monoclonal antibody to the DEC-205 receptor, an endocytic receptor that is abundant on these cells in lymphoid tissues. Simultaneously, we injected agonistic alpha-CD40 antibody to mature the dendritic cells. We found that a single low dose of antibody-conjugated ovalbumin initiated immunity from the naive CD4+ and CD8+ T cell repertoire. Unexpectedly, the alphaDEC-205 antigen conjugates, given s.c., targeted to dendritic cells systemically and for long periods, and ovalbumin peptide was presented on MHC class I for 2 weeks. This was associated with stronger CD8+ T cell-mediated immunity relative to other forms of antigen delivery, even when the latter was given at a thousand times higher doses. In parallel, the mice showed enhanced resistance to an established rapidly growing tumor and to viral infection at a mucosal site. By better harnessing the immunizing functions of maturing dendritic cells, antibody-mediated antigen targeting via the DEC-205 receptor increases the efficiency of vaccination for T cell immunity, including systemic and mucosal resistance in disease models.

  11. In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination

    Science.gov (United States)

    Bonifaz, Laura C.; Bonnyay, David P.; Charalambous, Anna; Darguste, Dara I.; Fujii, Shin-Ichiro; Soares, Helena; Brimnes, Marie K.; Moltedo, Bruno; Moran, Thomas M.; Steinman, Ralph M.

    2004-01-01

    The prevention and treatment of prevalent infectious diseases and tumors should benefit from improvements in the induction of antigen-specific T cell immunity. To assess the potential of antigen targeting to dendritic cells to improve immunity, we incorporated ovalbumin protein into a monoclonal antibody to the DEC-205 receptor, an endocytic receptor that is abundant on these cells in lymphoid tissues. Simultaneously, we injected agonistic α-CD40 antibody to mature the dendritic cells. We found that a single low dose of antibody-conjugated ovalbumin initiated immunity from the naive CD4+ and CD8+ T cell repertoire. Unexpectedly, the αDEC-205 antigen conjugates, given s.c., targeted to dendritic cells systemically and for long periods, and ovalbumin peptide was presented on MHC class I for 2 weeks. This was associated with stronger CD8+ T cell–mediated immunity relative to other forms of antigen delivery, even when the latter was given at a thousand times higher doses. In parallel, the mice showed enhanced resistance to an established rapidly growing tumor and to viral infection at a mucosal site. By better harnessing the immunizing functions of maturing dendritic cells, antibody-mediated antigen targeting via the DEC-205 receptor increases the efficiency of vaccination for T cell immunity, including systemic and mucosal resistance in disease models. PMID:15024047

  12. Overexpression of CYP3A4 in a COLO 205 Colon Cancer Stem Cell Model in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Olszewski, Ulrike [Ludwig Boltzmann Cluster of Translational Oncology, c/o Balderichgasse 26/13, A-1170 Vienna (Austria); Liedauer, Richard [Department of Pathophysiology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna (Austria); Ausch, Christoph [Department of Surgery, Danube Hospital, A-1220 Vienna (Austria); Thalhammer, Theresia [Department of Pathophysiology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna (Austria); Hamilton, Gerhard, E-mail: gerhard.hamilton@toc.lbg.ac.at [Ludwig Boltzmann Cluster of Translational Oncology, c/o Balderichgasse 26/13, A-1170 Vienna (Austria)

    2011-03-22

    Cancer stem cells (CSCs) seem to constitute a subpopulation of tumor cells that escape from chemotherapy and cause recurrent disease. Low proliferation rates, protection in a stem cell niche and overexpression of drug resistance proteins are considered to confer chemoresistance. We established an in vitro colon CSC-like model using the COLO 205 cell line, which revealed transiently increased expression of CD133 when transferred to serum-free stem cell culture medium. Assessment of global gene expression of COLO 205 cells under these conditions identified a set of upregulated genes including cytochrome P450 3A4 (CYP3A4) and aldehyde dehydrogenase 1A1 (ALDH1A1), as confirmed by real-time qPCR. ALDH1A1 is a CSC marker for certain tumor entities and confers resistance to cyclophosphamide. CYP3A4 is expressed in liver and colon and its overexpression seems particularly relevant in colon cancer, since it inactivates irinotecan and other xenobiotics, such as taxols and vinca alkaloids. In conclusion, this COLO 205 model provides evidence for CD133 induction concomitant with overexpression of CYP3A4, which, together with ATP-binding cassette, subfamily G, member 2 (ABCG2) and others, may have a role in chemoresistant colon CSCs and a negative impact on disease-free survival in colon cancer patients.

  13. Optimizing production of Pb beams for 205,210Pb analysis by Accelerator Mass Spectrometry

    Science.gov (United States)

    Sookdeo, Adam; Cornett, Jack; Kieser, William E.

    2015-10-01

    The measurement of rare radioactive lead isotopes (205Pb or 210Pb) by AMS requires the production of strong Pb negative molecular anion beams from the ion source. This paper summarizes the results of tests of different target composition on the strength and stability of 208PbF3- currents and 210Pb counts. In an 834 SIMS-type Cs+ sputter source, the superhalogen, PbF3- had the largest current or ionization efficiency from a survey of Pb molecular anions. The target matrix that produced the largest current of PbF3- was composed of PbF2, AgF2 and CsF. The ratio of AgF2 and CsF does not affect the ionization efficiency of PbF3-. Chemically refluxed targets of PbF2, AgF2 and CsF increased the ionization efficiency of PbF3-. The count rate of the rare isotope, 210Pb, was increased with the addition of microgram quantities of stable PbF2 to the targets. In an SO-110 type Cs+ sputter source the ionization efficiency of PbF3- was increased with lower rather than higher Cs+ fluence.

  14. Results of the radiological survey at 205 Main Street, Lodi, New Jersey (LJ075)

    International Nuclear Information System (INIS)

    Maywood Chemical Works (MCW) of Maywood, New Jersey, generated process wastes and residues associated with the production and refining of thorium and thorium compounds from monazite ores from 1916 to 1956. MCW supplied rare earth metals and thorium compounds to the Atomic Energy Commission and various other government agencies from the late 1940s to the mid-1950s. Area residents used the sandlike waste from this thorium extraction process mixed with tea and cocoa leaves as mulch in their yards. Some of these contaminated wastes were also eroded from the site into Lodi Brook. At the request of the US Department of Energy (DOE), a group from Oak Ridge National Laboratory conducts investigative radiological surveys of properties in the vicinity of MCW to determine whether a property is contaminated with radioactive residues, principally 232Th, derived from the MCW site. The survey typically includes direct measurement of gamma radiation levels and soil sampling for radionuclide analyses. The survey of this site, 205 Main Street, Lodi, New Jersey (LJ075), was conducted during 1987 and 1988. Results of the survey indicated radioactivity in the range of normal background for the northern New Jersey area. Radiological assessments of soil samples from the site demonstrate no radionuclide concentrations in excess of DOE Formerly Utilized Sites Remedial Action Program criteria. 5 refs., 21 figs., 3 tabs

  15. Super-luminous supernovae at redshifts of 2.05 and 3.90

    CERN Document Server

    Cooke, Jeff; Gal-Yam, Avishay; Barton, Elizabeth J; Carlberg, Raymond G; Ryan-Weber, Emma V; Horst, Chuck; Omori, Yuuki; Diaz, C Gonzalo; 10.1038/nature11521

    2012-01-01

    A rare class of `super-luminous' supernovae that are about ten or more times more luminous at their peaks than other types of luminous supernovae has recently been found at low to intermediate redshifts. A small subset of these events have luminosities that evolve slowly and result in radiated energies of around 10^51 ergs or more. Therefore, they are likely examples of `pair-instability' or `pulsational pair-instability' supernovae with estimated progenitor masses of 100 - 250 times that of the Sun. These events are exceedingly rare at low redshift, but are expected to be more common at high redshift because the mass distribution of the earliest stars was probably skewed to high values. Here we report the detection of two super-luminous supernovae, at redshifts of 2.05 and 3.90, that have slowly evolving light curves. We estimate the rate of events at redshifts of 2 and 4 to be approximately ten times higher than the rate at low redshift. The extreme luminosities of super-luminous supernovae extend the redsh...

  16. Optimizing numerical weather forecasting models for the CRAY-1 and cyber 205 computers

    Science.gov (United States)

    Dickinson, A.

    1982-06-01

    The Meteorological Office has recently acquired a Cyber 205 computer system which will be used to run large numerical models of the atmosphere and weather forecasting models. In particular a new operational forecast model has been developed for this computer and this is being coded to take full advantage of the vector capabilities of this machine. Development versions of this model have also been run on a Cray-1 at the European Centre for Medium Range Weather Forecasts. This has presented the opportunity to compare some of the features of these two computers. It is shown that in general numerical weather prediction models can be split into two sections, the dynamical and physical processes. In the dynamical processes the same operations are applied at every point in the integration domain and so these processes are readily vectorizable. However, the physical processes are conditional and intermittent in nature and use must be made of the mask/merge, compress/expand and gather/scatter class of instructions in order to vectorize these processes.

  17. Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines.

    Science.gov (United States)

    Huang, Wen; Massouras, Andreas; Inoue, Yutaka; Peiffer, Jason; Ràmia, Miquel; Tarone, Aaron M; Turlapati, Lavanya; Zichner, Thomas; Zhu, Dianhui; Lyman, Richard F; Magwire, Michael M; Blankenburg, Kerstin; Carbone, Mary Anna; Chang, Kyle; Ellis, Lisa L; Fernandez, Sonia; Han, Yi; Highnam, Gareth; Hjelmen, Carl E; Jack, John R; Javaid, Mehwish; Jayaseelan, Joy; Kalra, Divya; Lee, Sandy; Lewis, Lora; Munidasa, Mala; Ongeri, Fiona; Patel, Shohba; Perales, Lora; Perez, Agapito; Pu, LingLing; Rollmann, Stephanie M; Ruth, Robert; Saada, Nehad; Warner, Crystal; Williams, Aneisa; Wu, Yuan-Qing; Yamamoto, Akihiko; Zhang, Yiqing; Zhu, Yiming; Anholt, Robert R H; Korbel, Jan O; Mittelman, David; Muzny, Donna M; Gibbs, Richard A; Barbadilla, Antonio; Johnston, J Spencer; Stone, Eric A; Richards, Stephen; Deplancke, Bart; Mackay, Trudy F C

    2014-07-01

    The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring genetic variation on molecular and organismal phenotypes. We used an integrated genotyping strategy to identify 4,853,802 single nucleotide polymorphisms (SNPs) and 1,296,080 non-SNP variants. Our molecular population genomic analyses show higher deletion than insertion mutation rates and stronger purifying selection on deletions. Weaker selection on insertions than deletions is consistent with our observed distribution of genome size determined by flow cytometry, which is skewed toward larger genomes. Insertion/deletion and single nucleotide polymorphisms are positively correlated with each other and with local recombination, suggesting that their nonrandom distributions are due to hitchhiking and background selection. Our cytogenetic analysis identified 16 polymorphic inversions in the DGRP. Common inverted and standard karyotypes are genetically divergent and account for most of the variation in relatedness among the DGRP lines. Intriguingly, variation in genome size and many quantitative traits are significantly associated with inversions. Approximately 50% of the DGRP lines are infected with Wolbachia, and four lines have germline insertions of Wolbachia sequences, but effects of Wolbachia infection on quantitative traits are rarely significant. The DGRP complements ongoing efforts to functionally annotate the Drosophila genome. Indeed, 15% of all D. melanogaster genes segregate for potentially damaged proteins in the DGRP, and genome-wide analyses of quantitative traits identify novel candidate genes. The DGRP lines, sequence data, genotypes, quality scores, phenotypes, and analysis and visualization tools are publicly available.

  18. Satellite and terrestrial narrow-band propagation measurements at 2.05 GHz

    Science.gov (United States)

    Vaisnys, Arv; Vogel, Wolf

    1995-08-01

    A series of satellite and terrestrial propagation measurements were conducted on 15 and 16 Dec. 1994 in the vicinity of the Jet Propulsion Laboratory (JPL), Pasadena, California, in support of the VOA/JPL DBS-Radio Program. The reason for including terrestrial measurements was the possible use of terrestrial boosters to improve reception in some satellite digital audio broadcasting system service areas. The signal sources used were the NASA TDRS satellite located at 171 degrees West and a terrestrial transmitter located on a high point on JPL property. Both signals were unmodulated carriers near 2.05 GHz, spaced a few kHz apart so that both could be received simultaneously by a single receiver. An unmodulated signal was used in order to maximize the dynamic range of the signal strength measurement. A range of greater than 35 dB was achieved with the satellite signal, and over 50 dB was achieved with the terrestrial signal measurements. Three test courses were used to conduct the measurements: (1) a 33 km round trip drive from JPL through Pasadena was used to remeasure the propagation of the satellite signal over the path previously used in DBS-Radio experiments in mid 1994. A shortened portion of this test course, approximately 20 km, was used to measure the satellite and terrestrial signals simultaneously; (2) a 9 km round trip drive through JPL property, going behind buildings and other obstacles, was used to measure the satellite and terrestrial signals simultaneously; and (3) a path through one of the buildings at JPL, hand carrying the receiver, was also used to measure the satellite and terrestrial signals simultaneously.

  19. The 5-HT3 receptor antagonists ICS 205-930 and GR38032F, putative anxiolytic drugs, differ from diazepam in their pharmacological profile.

    Science.gov (United States)

    Papp, M; Przegalinski, E

    1989-01-01

    The pharmacological profile of the two 5-HT(3) (5-hydroxytryptamine) receptor antagonists, the putative anxiolytics ICS 205-930 and GR38032F was compared with that of diazepam in four standard behavioural tests in rats. All the investigated drugs induced an anxiolytic effect in the passive avoidance test, having reduced the latency to re-enter the chamber previously associated with an inescapable footshock, and increased the time spent in that chamber. On the basis of the lowest effective dose, both ICS 205-930 and GR38032F were about 20 times more potent than diazepam, though the anxiolytic activity of either 5- HT(3) receptor antagonist was confined to a narrow dose range (ICS 205-930: 93.7-187.5 μg/ kg, GR38032F: 125-375 μg/kg), their higher doses having been ineffective. The anxiolytic effect of diazepam, but not of ICS 205-930, was abolished by flumazenil. In contrast to diazepam, neither ICS 205-930 nor GR38032F-both given in doses up to 20 mg/kg-showed any activity in the pentylenetetrazol-induced seizures, open field, and rota-rod tests. These results suggest that the 5-HT(3) receptor antagonists may represent a new class of anxiolytic drugs devoid of anticonvulsant, sedative or muscle-relaxant properties, and that their anxi olytic activity is not mediated by benzodiazepine receptors.

  20. Vortex states of Tl2Ba2CuO6+δ studied via 205Tl NMR at 2 tesla

    International Nuclear Information System (INIS)

    We report a 205Tl NMR study of vortex states in an aligned polycrystalline sample of an overdoped high-Tc superconductor, Tl2Ba2CuO6+δ (Tc - 85 K), at a magnetic field of 2 T along the c axis. We observed an imperfect vortex lattice, so-called Bragg glass, at T=5 K, the coexistence of vortex solid and vortex liquid between 10 and 60 K, and vortex melting between 65 and 85 K. No evidence for local antiferromagnetic ordering at vortex cores was found for our sample. (author)

  1. Improved absorption cross-sections of oxygen in the wavelength region 205-240 nm of the Herzberg continuum

    Science.gov (United States)

    Yoshino, K.; Cheung, A. S.-C.; Esmond, J. R.; Parkinson, W. H.; Freeman, D. E.

    1988-01-01

    The laboratory values of the Herzberg continuum absorption cross-section of oxygen at room temperature from Cheung et al. (1986) and Jenouvrier et al. (1986) are compared and analyzed. It is found that there is no discrepancy between the absolute values of these two sets of independent measurements. The values are combined in a linear least-squares fit to obtain improved values of the Herzberg continuum cross-section of oxygen at room temperature throughout the wavelength region 205-240 nm. The results are compared with in situ and other laboratory measurements.

  2. Computer Simulation on Low Pressure Plaster Mold Casting Process for ZL205A Alloy%铸铝ZL205A石膏型低压铸造工艺计算机模拟

    Institute of Scientific and Technical Information of China (English)

    王狂飞; 周志杰; 王有超; 历长云

    2011-01-01

    利用View Cast软件对某低压石膏型ZL205A铸件铸造过程进行了计算机模拟,获得了铸件充型、凝固过程温度随时间变化的分布图,并对可能产生缩孔、缩松缺陷的位置进行了预测.模拟结果显示,低压铸造充型过程中降温不明显,而熔液流经大截面时产生速度降;凝固过程中,熔体自顶向下形成逐层递增的温度梯度,利于熔体补缩.模拟结果与实际生产情况吻合较好.%The low pressure plaster mold casting process for ZL205A alloy was simulated by View Cast software, and the relationship between cast temperature and time were obtained in casting solidification and filling, and the location of the shrinkage defects were also forecasted. The results show that the temperature of liquid metal invisibly drops during mold filling, and the melt filling rate decreases with the increase of cross-section with the ingate, and increasing temperature gradient of melt from up to down can contribute to the shrinkage elimination of casting during solidifying. The simulations reasonably agree well with production results.

  3. Planetary nebulae: the universal mass-metallicity relation for Local Group dwarf galaxies and the chemistry of NGC 205

    CERN Document Server

    Gonçalves, D R; Teodorescu, Ana M; Carneiro, Carolina M

    2014-01-01

    Here we study 16 planetary nebulae (PNe) in the dwarf irregular galaxy NGC 205 by using GMOS@Gemini spectra to derive their physical and chemical parameters. The chemical patterns and evolutionary tracks for 14 of our PNe suggest that there are no type I PNe among them. These PNe have an average oxygen abundance of 12+log(O/H)=8.08$\\pm$0.28, progenitor masses of 2-2.5M$_{\\odot}$ and thus were born ~1.0-1.7Gyr ago. Our results are in good agreement with previous PN studies in NGC 205. The present 12+log(O/H) is combined with our previous works and with the literature to study the PN metallicity trends of the Local Group (LG) dwarf galaxies, in an effort to establish the PN luminosity- and mass-metallicity relations (LZR and MZR) for the LG dwarf irregulars (dIrrs) and dwarf spheroidals (dSphs). Previous attempts to obtain such relations failed to provide correct conclusions because were based on limited samples (Richer & McCall 1995; Gon\\c{c}calves et al. 2007). As far as we are able to compare stellar wit...

  4. The Ionized Gas in Nearby Galaxies as Traced by the [NII] 122 and 205 \\mu m Transitions

    CERN Document Server

    Herrera-Camus, R; Smith, J D; Draine, B; Pellegrini, E; Wolfire, M; Croxall, K; de Looze, I; Calzetti, D; Kennicutt, R; Crocker, A; Armus, L; van der Werf, P; Sandstrom, K; Galametz, M; Brandl, B; Groves, B; Rigopoulou, D; Walter, F; Leroy, A; Boquien, M; Tabatabaei, F S; Beirao, P

    2016-01-01

    The [NII] 122 and 205 \\mu m transitions are powerful tracers of the ionized gas in the interstellar medium. By combining data from 21 galaxies selected from the Herschel KINGFISH and Beyond the Peak surveys, we have compiled 141 spatially resolved regions with a typical size of ~1 kiloparsec, with observations of both [NII] far-infrared lines. We measure [NII] 122/205 line ratios in the ~0.6-6 range, which corresponds to electron gas densities $n_e$~1-300 cm$^{-3}$, with a median value of $n_e$=30 cm$^{-3}$. Variations in the electron density within individual galaxies can be as a high as a factor of ~50, frequently with strong radial gradients. We find that $n_e$ increases as a function of infrared color, dust-weighted mean starlight intensity, and star formation rate surface density ($\\Sigma_{SFR}$). As the intensity of the [NII] transitions is related to the ionizing photon flux, we investigate their reliability as tracers of the star formation rate (SFR). We derive relations between the [NII] emission and...

  5. Equilibrium binding constants for Tl+ with gramicidins A, B and C in a lysophosphatidylcholine environment determined by 205Tl nuclear magnetic resonance spectroscopy.

    OpenAIRE

    Hinton, J F; Koeppe, R E; Shungu, D; Whaley, W L; Paczkowski, J A; Millett, F S

    1986-01-01

    Nuclear Magnetic Resonance (NMR) 205Tl spectroscopy has been used to monitor the binding of Tl+ to gramicidins A, B, and C packaged in aqueous dispersions of lysophosphatidylcholine. For 5 mM gramicidin dimer in the presence of 100 mM lysophosphatidylcholine, only approximately 50% or less of the gramicidin appears to be accessible to Tl+. Analysis of the 205Tl chemical shift as a function of Tl+ concentration over the 0.65-50 mM range indicates that only one Tl+ ion can be bound by gramicidi...

  6. MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells

    Directory of Open Access Journals (Sweden)

    Yamashita Shunichi

    2011-03-01

    Full Text Available Abstract Background Esophageal squamous cell carcinoma (ESCC is often diagnosed at later stages until they are incurable. MicroRNA (miR is a small, non-coding RNA that negatively regulates gene expression mainly via translational repression. Accumulating evidence indicates that deregulation of miR is associated with human malignancies including ESCC. The aim of this study was to identify miR that could be specifically expressed and exert distinct biological actions in ESCC. Methods Total RNA was extracted from ESCC cell lines, OE21 and TE10, and a non-malignant human esophageal squamous cell line, Het-1A, and subjected to microarray analysis. Expression levels of miR that showed significant differences between the 2 ESCC and Het-1A cells based on the comprehensive analysis were analyzed by the quantitative reverse transcriptase (RT-PCR method. Then, functional analyses, including cellular proliferation, apoptosis and Matrigel invasion and the wound healing assay, for the specific miR were conducted. Using ESCC tumor samples and paired surrounding non-cancerous tissue obtained endoscopically, the association with histopathological differentiation was examined with quantitative RT-PCR. Results Based on the miR microarray analysis, there were 14 miRs that showed significant differences (more than 2-fold in expression between the 2 ESCC cells and non-malignant Het-1A. Among the significantly altered miRs, miR-205 expression levels were exclusively higher in 5 ESCC cell lines examined than any other types of malignant cell lines and Het-1A. Thus, miR-205 could be a specific miR in ESCC. Modulation of miR-205 expression by transfection with its precursor or anti-miR-205 inhibitor did not affect ESCC cell proliferation and apoptosis, but miR-205 was found to be involved in cell invasion and migration. Western blot revealed that knockdown of miR-205 expression in ESCC cells substantially enhanced expression of zinc finger E-box binding homeobox 2

  7. 23上205综采工作面过薄煤区回采对策与实践%Countermeasure and practice of 23 205 fully mechanized working face Mining through the Seam thinned area

    Institute of Scientific and Technical Information of China (English)

    宋崇崇; 朱朝领

    2014-01-01

    综合分析23上205综采工作面无煤区地质情况和现用回采设备技术参数,研究对策,制定安全开采措施与合理回采方案,实现不搬家不跳采且达到综采面安全回采的目的。%This paper comprehensively analyzed the geological conditions of no coal zone and the current mining equipment and technology parameters of 23205 fully mechanized working face, researched countermeasure, formulated the safety mining measures and reasonable mining scheme, and achieved the safety mining of fully mechanized mining face without moving and skip-mining.

  8. miR-184及miR-205在绵羊不同生长时期毛囊及其他组织中的表达研究%The Study on Expression of miR-184 and miR-205 at Different Developmental Stages of Hair Follicle and Other Tissues of Sheep

    Institute of Scientific and Technical Information of China (English)

    唐晓惠; 柳广斌; 杜小勇; 曹建华; 李新云; 罗章; 余梅; 赵书红

    2012-01-01

    In order to study the roles of miR-184 and miR205 in hair follicle development of sheep, the expression of miR-184 and miR-205 at three different developmental stages of hair follicle of sheep was detected by QPCR. The precursors of the two microRNAs was predicted and the sequences were mapped to genome of sheep. Furthermore target genes and pathways of the two microRNAs were predicted. The results indicated that the expression of miR-184 in hair follicle tissue showed increasing trend from anagen to telogen. However, the miR-205 was upregulated from anagen to catagen, and then downregulated from catagen to telogen. The expression of miR-205 was highest in catagen. miR-184 and miR-205 both express in many different tiusses. Moreover, the candidate target genes of the two microRNAs are involved in 15 different pathways and miR-184 and miR-205 probably regulate the hair follicle development through Wnt signaling pathway.%为了研究miR-184及miR-205在绵羊毛囊发育过程中的作用,本研究以绵羊为研究材料,检测了miR-184及miR-205在毛囊3个发育时期及不同组织中的表达情况,进行了基因组定位及前体预测,并预测了可能的靶基因及调控的基因通路.结果发现,miR-184的表达量从毛囊生长期到衰退期呈逐步上升的趋势,而miR-205则表现为先上升后下降,其在衰退期表达量最高.2个microRNA在绵羊的多个组织中均有表达.两者的候选靶基因涉及15个基因通路,可能通过Wnt通路调控毛囊的生长周期.

  9. 膀胱尿路上皮癌及正常膀胱组织microRNA21、205表达研究%Expression of miR-21 and miR-205 in urothelial cell carcinoma of bladder and normal bladder mucosa

    Institute of Scientific and Technical Information of China (English)

    马杰; 姜宁; 王国增; 郑景存; 贺伟; 刁海彦

    2012-01-01

    目的 探讨microRNAs (miRNAs)在膀胱尿路上皮癌与正常膀胱组织中的表达差异性及意义.方法 采用基于2-△△cT的实时定量PCR(Real-time PCR)方法 检测50例膀胱尿路上皮癌与21例正常膀胱组织中miR-21及miR-205的表达情况.结果 与正常组织相比,癌组织miR-21表达上调(P<0.01),miR-205表达下调(P<o.o1).癌组织中miR-21与miR-205表达量的比值约3.6倍于正常组织中表达量的比值.结论 miR-21高表达、miR-205低表达可能参与膀胱尿路上皮癌的发生、发展.%Objective To detect the expression of miR-21 and miR-205 in urothelial cell carcinoma of bladder and normal bladder mucosa and explore the relationship between microRNAs (miRNAs) and urothelial cell carcinoma of bladder. Methods 2△△CT Real-time PCR method was used for quantitative analysis of the expression of miR-21 and miR-205 in 50 urothelial cell carcinoma of bladder and 21 normal bladder tissues. Results Compared with normal bladder mucosa, the urothelial cell carcinoma of bladder tissues showed significant miR-21 over-expression (P<0. 01) and miR-205 down-regulation (P <0. 01). Cancer tissue showed miR-21: miR-205 ratio at least 3.6-fold higher than the quantitative ratio obtained from normal bladder tissue. Conclusion The over expression of miR-21 and lower expression of miR-205 may participate in recurrence urothelial cell carcinoma of bladder.

  10. 205 nm continuous-wave laser: application to the measurement of the Lamb shift in hydrogen; Laser continu a 205 nm: application a la mesure du deplacement de lamb dans l'hydrogene

    Energy Technology Data Exchange (ETDEWEB)

    Bourzeix, S

    1995-01-15

    The subject of this thesis is the construction of an experimental set-up, and in particular of a tunable continuous-wave laser at 205 nm, for the measurement of the ground state Lamb shift in atomic hydrogen. Chapter 1 deals with the Lamb shift from a historical point of view, and with the interest of its measurement, for metrology and test of quantum electrodynamics. Chapter 2 is devoted to the theory of the hydrogen atom. The principle of the experiment is based on the comparison of two frequencies which are in a ratio of 4: those of the two-photon transitions of 2S-6S or 2S-6D and 1S-3S. Chapter 3 describes the experimental set-up used to measure the 2S-6D transition which is excited by a titanium-sapphire laser at 820 nm. The 205 nm light required to excite the 1S-3S transition is generated by two frequency-doubling of the titanium-sapphire laser, made in non-linear crystals placed in enhancement cavities. Chapter 4 is entirely devoted to the frequency-doubling. After a recall of non-linear optics, the enhancement cavities are described in detail, as well as the results we achieved. At last chapter 5 describes the research for a signal on the 1S-3S transition: the construction of a ground state atomic beam, and the development of the detection system. This work has led to a preliminary measurement of the ground state Lamb shift in atomic hydrogen: L(1S) = 8172.850 (174) MHz whose result is in very good agreement with both the previous measurements and the most recent theoretical results. (author)

  11. 17 CFR 275.205-1 - Definition of “investment performance” of an investment company and “investment record” of an...

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Definition of âinvestment performanceâ of an investment company and âinvestment recordâ of an appropriate index of securities prices. 275... (CONTINUED) RULES AND REGULATIONS, INVESTMENT ADVISERS ACT OF 1940 § 275.205-1 Definition of...

  12. Inhibition of fibrin polymerization by synthetic peptides corresponding to Aalpha195-205 and gamma69-77 sites of fibrin molecule

    NARCIS (Netherlands)

    Pozniak, T.A.; Urvant, L.P.; Gritsenko, P.; Chernishov, V.I.; Pydiura, N.A.; Lugovskoi, E.V.; Komisarenko, S.V.

    2014-01-01

    Using the idea of "proline brackets" we have found four sites in fibrin amino acid sequence, and appropriate peptides were synthesized: gamma69NPDESSKPN77, Bbeta228QPDSSVKPY236, Bbeta455RPFFPQ460 and Aalpha195LPSRDRQHLPL205. Turbidity and electron-microscopy analyses have demonstrated that synthetic

  13. Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions

    Directory of Open Access Journals (Sweden)

    Kerry J. Welsh

    2011-01-01

    Full Text Available Postprimary tuberculosis occurs in immunocompetent people infected with Mycobacterium tuberculosis. It is restricted to the lung and accounts for 80% of cases and nearly 100% of transmission. Little is known about the immunopathology of postprimary tuberculosis due to limited availability of specimens. Tissues from 30 autopsy cases of pulmonary tuberculosis were located. Sections of characteristic lesions of caseating granulomas, lipid pneumonia, and cavitary stages of postprimary disease were selected for immunohistochemical studies of macrophages, lymphocytes, endothelial cells, and mycobacterial antigens. A higher percentage of cells in lipid pneumonia (36.1% and cavitary lesions (27.8% were positive for the dendritic cell marker DEC-205, compared to granulomas (9.0%, P<.05. Cavities contained significantly more T-regulatory cells (14.8% than found in lipid pneumonia (5.2% or granulomas (4.8%. Distribution of the immune cell types may contribute to the inability of the immune system to eradicate tuberculosis.

  14. Clustering dynamics in water/methanol mixtures: a nuclear magnetic resonance study at 205 k

    Science.gov (United States)

    Corsaro, Carmelo; Spooren, Jeroen; Branca, Caterina; Leone, Nancy; Broccio, Matteo; Kim, Chansoo; Chen, Sow-Hsin; Stanley, H Eugene; Mallamace, Francesco

    2008-08-28

    Proton nuclear magnetic resonance (1H NMR) experiments have been performed to measure the spin-lattice, T1, and spin-spin, T2, relaxation times of the three functional groups in water/methanol mixtures at different methanol molar fractions (XMeOH=0, 0.04, 0.1, 0.24, 0.5, 1) as a function of temperature in the range 205 Kpure water and methanol because of strong interactions, resulting in a complex hydrogen bonding dynamics that determines their thermodynamic properties. In particular, we observe how the interplay between hydrophobicity and hydrophilicity changes with temperature and influences the peculiar thermal behavior of the NMR relaxation times of the solution. The obtained results are interpreted in terms of the existence of stable water-methanol clusters at high temperature whereas, upon cooling to low temperature, clusters of single species are present in the mixture. PMID:18672927

  15. Magnetocaloric properties of the Gd_5Si_(2.05-x)Ge_(1.95-x)Mn_(2x) compounds

    Institute of Scientific and Technical Information of China (English)

    E.Yüzüak; I.Dincer; Y.Elerman

    2010-01-01

    The influence of the manganese-alloying on the structure and magnetocaloric properties of the Gd5Si2.05Ge1.95 compound was studied by X-ray powder diffraction and magnetization measurements.The Gd5Si2.05-xGe1.95-xMn2x(2x=0,0.03 and 0.08) compounds crystallized in the Gd5Si2Ge2-type monoclinic structure.In all X-ray powder diffraction patterns,a minor hexagonal Gd5Si3 phase was observed as a second phase.With increasing Mn content,the unit cell volume increased.For the compounds with x=0,0.03 and 0.08,the fi...

  16. A HERSCHEL SURVEY OF THE [N II] 205 μm LINE IN LOCAL LUMINOUS INFRARED GALAXIES: THE [N II] 205 μm EMISSION AS A STAR FORMATION RATE INDICATOR

    International Nuclear Information System (INIS)

    We present, for the first time, a statistical study of [N II] 205 μm line emission for a large sample of local luminous infrared galaxies using Herschel Spectral and Photometric Imaging Receiver Fourier Transform Spectrometer (SPIRE FTS) data. For our sample of galaxies, we investigate the correlation between the [N II] luminosity (L[NII]) and the total infrared luminosity (LIR), as well as the dependence of L[NII]/LIR ratio on LIR, far-infrared colors (IRAS f60/f100), and the [O III] 88 μm to [N II] luminosity ratio. We find that L[NII] correlates almost linearly with LIR for non-active galactic nucleus galaxies (all having LIR 12 L☉) in our sample, which implies that L[NII] can serve as a star formation rate tracer which is particularly useful for high-redshift galaxies that will be observed with forthcoming submillimeter spectroscopic facilities such as the Atacama Large Millimeter/submillimeter Array. Our analysis shows that the deviation from the mean L[NII]-LIR relation correlates with tracers of the ionization parameter, which suggests that the scatter in this relation is mainly due to the variations in the hardness, and/or ionization parameter, of the ambient galactic UV field among the sources in our sample.

  17. Along the N=126 closed shell: study of $^{205}$Au through its $\\pi h_{11/2}^{-1}$ isomeric decay

    CERN Multimedia

    2002-01-01

    Excited states have been identified in only three of the N=126 closed shell nuclei 'below' $^{208}$Pb, $^{207}$Tl, $^{206}$Hg and very recently $^{204}$Pt. We aim to extend our knowledge of the neutron-rich N=126 nuclei by observing the internal decay of the $\\pi h^{-1}_{11/2}$ excited state in $^{205}$Au, which is expected to be isomeric. In addition, the decay of the analogous states in the N=122 and N=124 $^{201,203}$Au will be studied. The lifetimes of the expected isomeric states are crucial for the success of the experiment, and they are estimated to be in the range of 0.3-20 s. These are long enough to enable the extraction from the source, but shorter than the $\\beta$-decay half-lives. Proton single-particle energies and transition rates will be extracted, providing information about the robustness of the N=126 shell-closure. Three days of beam-time is requested.

  18. Cuminaldehyde from Cinnamomum verum Induces Cell Death through Targeting Topoisomerase 1 and 2 in Human Colorectal Adenocarcinoma COLO 205 Cells.

    Science.gov (United States)

    Tsai, Kuen-Daw; Liu, Yi-Heng; Chen, Ta-Wei; Yang, Shu-Mei; Wong, Ho-Yiu; Cherng, Jonathan; Chou, Kuo-Shen; Cherng, Jaw-Ming

    2016-01-01

    Cinnamomum verum, also called true cinnamon tree, is employed to make the seasoning cinnamon. Furthermore, the plant has been used as a traditional Chinese herbal medication. We explored the anticancer effect of cuminaldehyde, an ingredient of the cortex of the plant, as well as the molecular biomarkers associated with carcinogenesis in human colorectal adenocarcinoma COLO 205 cells. The results show that cuminaldehyde suppressed growth and induced apoptosis, as proved by depletion of the mitochondrial membrane potential, activation of both caspase-3 and -9, and morphological features of apoptosis. Moreover, cuminaldehyde also led to lysosomal vacuolation with an upregulated volume of acidic compartment and cytotoxicity, together with inhibitions of both topoisomerase I and II activities. Additional study shows that the anticancer activity of cuminaldehyde was observed in the model of nude mice. Our results suggest that the anticancer activity of cuminaldehyde in vitro involved the suppression of cell proliferative markers, topoisomerase I as well as II, together with increase of pro-apoptotic molecules, associated with upregulated lysosomal vacuolation. On the other hand, in vivo, cuminaldehyde diminished the tumor burden that would have a significant clinical impact. Furthermore, similar effects were observed in other tested cell lines. In short, our data suggest that cuminaldehyde could be a drug for chemopreventive or anticancer therapy. PMID:27231935

  19. Sensitization of colon cancer cells (COLO205) treated with Doxorubicin to rHuTNF- mediated cytotoxicity%阿霉素对重组人肿瘤坏死因子介导的结肠癌细胞 (COLO205)细胞毒增敏作用

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    目的:评价阿霉素和rHuTNF抗人结肠癌细胞株的序贯作用.方法:采用克隆生成试验(Hamburger-Salmon法),研究DOX和rHuTNF序贯作用于COLO205细胞株后的抗增殖效果.结果:对结肠癌细胞系COLO205,存在DOX-rHuTNF序贯抗增殖作用;多数联合给药情况下出现相加/协同作用.结论:DOX存在时,TNF的抗瘤作用增强,从而支持DOX可干扰细胞保护机制以使瘤细胞对TNF细胞毒作用更为敏感的理论.%Objective:To evaluate the sequential action of rHuTNF and doxorubicin (DOX) against human colon cancer cell line (COLO205). Methods:With clonogenic assay(Hamburger- Salmon method), the sequential roles of rHuTNF and DOX on COLO205 were investigated. The dose - effect relationships of each drug alone and in combination were analyzed by examining the survival fraction of the drug combination. Results: The action of DOX and rHuTNF against proliferation was found to be schedule - dependent in colon cancer line COLO205;marked synergistic effects were observed in most instances of treatment, when DOX was administered prior to and not following rHuTNF. Conclusion: The anti - tumor effect of TNF can be enhanced in the presence of DOX,suggestion that the addition of DOX may interfere with the cellular protective mechanism, causing the tumor cells to become more susceptible to the cytotoxic action of TNF.

  20. A HERSCHEL SURVEY OF THE [N II] 205 {mu}m LINE IN LOCAL LUMINOUS INFRARED GALAXIES: THE [N II] 205 {mu}m EMISSION AS A STAR FORMATION RATE INDICATOR

    Energy Technology Data Exchange (ETDEWEB)

    Zhao Yinghe; Gao Yu [Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China); Lu, Nanyao; Xu, C. Kevin; Lord, S.; Howell, J.; Appleton, P.; Mazzarella, J.; Schulz, B. [Infrared Processing and Analysis Center, California Institute of Technology, MS 100-22, Pasadena, CA 91125 (United States); Isaak, K. G. [ESA Astrophysics Missions Division, ESTEC, PO Box 299, 2200 AG Noordwijk (Netherlands); Charmandaris, V. [Department of Physics and ITCP, University of Crete, GR-71003 Heraklion (Greece); Diaz-Santos, T.; Surace, J. [Spitzer Science Center, California Institute of Technology, MS 220-6, Pasadena, CA 91125 (United States); Evans, A. [Department of Astronomy, University of Virginia, 530 McCormick Road, Charlottesville, VA 22904 (United States); Iwasawa, K. [ICREA and Institut de Ciencies del Cosmos (ICC), Universitat de Barcelona (IEEC-UB), Marti i Franques 1, E-08028 Barcelona (Spain); Leech, J. [Department of Physics, University of Oxford, Denys Wilkinson Building, Keble Road, Oxford OX1 3RH (United Kingdom); Petric, A. O. [Astronomy Department, California Institute of Technology, Pasadena, CA 91125 (United States); Sanders, D. B. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Van der Werf, P. P., E-mail: yhzhao@ipac.caltech.edu [Leiden Observatory, Leiden University, PO Box 9513, 2300 RA Leiden (Netherlands)

    2013-03-01

    We present, for the first time, a statistical study of [N II] 205 {mu}m line emission for a large sample of local luminous infrared galaxies using Herschel Spectral and Photometric Imaging Receiver Fourier Transform Spectrometer (SPIRE FTS) data. For our sample of galaxies, we investigate the correlation between the [N II] luminosity (L{sub [N{sub II]}}) and the total infrared luminosity (L{sub IR}), as well as the dependence of L{sub [N{sub II]}}/L{sub IR} ratio on L{sub IR}, far-infrared colors (IRAS f{sub 60}/f{sub 100}), and the [O III] 88 {mu}m to [N II] luminosity ratio. We find that L{sub [N{sub II]}} correlates almost linearly with L{sub IR} for non-active galactic nucleus galaxies (all having L{sub IR} < 10{sup 12} L{sub Sun }) in our sample, which implies that L{sub [N{sub II]}} can serve as a star formation rate tracer which is particularly useful for high-redshift galaxies that will be observed with forthcoming submillimeter spectroscopic facilities such as the Atacama Large Millimeter/submillimeter Array. Our analysis shows that the deviation from the mean L{sub [N{sub II]}}-L{sub IR} relation correlates with tracers of the ionization parameter, which suggests that the scatter in this relation is mainly due to the variations in the hardness, and/or ionization parameter, of the ambient galactic UV field among the sources in our sample.

  1. 肌萎缩侧索硬化患者205例的神经传导特点分析%Nerve conduction studies in 205 patients with amyotrophic lateral sclerosis

    Institute of Scientific and Technical Information of China (English)

    冯新红; 崔丽英; 刘明生; 管宇宙; 李本红; 杜华

    2011-01-01

    Objective To investigate the F-wave and nerve conduction in patients with amyotrophic lateral sclerosis (ALS) and explore the correlation between these parameters and muscle strength, disease duration and onset site.Methods The data of outpatients and inpatients diagnosed with ALS were collected in Peking Union Medical College Hospital from January 1997 to May 2008.Standard sensory and motor nerve conduction study of the median nerve, ulnar nerve and tibial nerve was performed in 205 patients with ALS.F-wave velocity and frequency was measured in median nerve.Parameters for analyses included sensory conduction velocity and amplitude, distal motor latency (DML), and compound muscle action potential (CMAP) amplitude.Correlation between muscle strength and DML, CMAP amplitude or F-wave frequency were also explored.Results Delayed DML of the median nerve, ulnar nerve and tibial nerve were found in 24.9% (48/193), 15.3% (25/163), 21.2% (7/33) of patients respectively.Decreased CMAP amplitudes were found in 57.0% (110/193), 49.7% (81/163), 39.4% (13/33) of patients respectively.Decreased F-wave frequency of the median nerve was found in 68.9% (122/177) of patients.The abnormality of DML,CMAP amplitude and F-wave frequency of median nerve were increased in weaker muscles.Decreased median nerve CMAP amplitude (81.5% (53/65)) and F-wave abnormality (decreased persistence 70.9%(44/62), absent responses 45.1% (28/62)) in spinal onset groups were significantly higher than those in bulbar onset groups (CMAP 32.4% (11/34); F-wave: decreased persistence 38.2% (13/34), absent responses 14.7% (5/34); x2 = 23.629, 9.753, 9.029,all P <0.01).Compared with the bulbar onset group,the abnormality of DML in spinal onset group was higher, but not reach statistical significance.Logistic regression revealed a strong direct association between decreased CMAP amplitudes and upperextremity muscles strength, disease duration and onset symptom.Abnormality of F-wave frequency was associated with

  2. Expression and clinical value analysis of plasma miR-205, miR-212 and miR-429 in ovarian cancer%卵巢癌患者血浆miR-205、miR-212及miR-429的水平分析及意义∗

    Institute of Scientific and Technical Information of China (English)

    穆鹏; 李联崑; 贾海清; 王晓彬

    2015-01-01

    Objective To explore the levels of plasma miR⁃205, miR⁃212 and miR⁃429 in ovarian cancer and analyze the re⁃lationship between the above indicators and clinical pathology parameters of ovarian cancer. Methods Plasma samples from 71 ovarian cancer patients before treatment were collected. The real⁃time quantitative RT⁃PCR ( qRT⁃PCR) was used to detect the levels of miR⁃205, miR⁃212 and miR⁃429, and the clinical pathology parameters of ovarian cancer ( age, clinical stage, degree of differentiation, histological type and lymph node metastasis) were collected. The clinical pathology parameters of patients with different levels of miR⁃205, miR⁃212 and miR⁃429 were compared. The receiver operating characteristic curve ( ROC) was employed to analyze the clinical value of plasma miR⁃205, miR⁃212 and miR⁃429 in the diagnosis of ovarian cancer. Meanwhile, the plasma samples from 68 healthy volunteers (healthy control group) and 66 patients with benign ovarian tumor (benign group) were collected as control. Results There were higher levels of miR⁃205 and but lower miR⁃212 and miR⁃429 in ovarian cancer group versus other two groups with signifi⁃cant difference ( P all<0�05) . In ovarian cancer, the level of miR⁃205 was related with age, clinical stage, degree of differentiation and lymph node metastasis, and miR⁃212 was related with clinical stage and degree of differentiation, and miR⁃429 was related with clinical stage and lymph node metastasis ( P all<0�05) . The plasma level of miR⁃205 was negatively correlated with miR⁃212 and miR⁃429 ( r=-0�572、-0�325) , and miR⁃212 was positively correlated with miR⁃429 with statistically significance ( r=0�473,P<0�05) . The AUC, sensitivity and specificity of plasma miR⁃205, miR⁃212 and miR⁃429 in the diagnosis of ovarian cancer were 0�915, 92�1%and 86�2%, 0�944,87�3% and 91�0%, and 0�905, 88�5% and 83�6%. Conclusion There was higher

  3. Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells

    Institute of Scientific and Technical Information of China (English)

    ZU Xiao-yan; ZHANG Zhen-ya; ZHANG Xiao-wen; YOSHIOKA Masahiro; YANG Ying-nan; LI Ji

    2010-01-01

    Background Vaccinium uliginosum L. is a type of blueberry found in the Chinese Changbai Mountains. We extracted Vaccinium uliginosurn Anthocyanins (Av.uli) to investigate its bioactivity on suppressing cancer cells.Methods Av.uli was extracted under different conditions of temperature (10℃-35℃), pH 1.0-3.0, and diatomaceous earth (1.0 g-3.0 g), followed by a HPLC analysis for the determination of the ingredients. Its anticancer bioactivities on human colon and colorectal cancer cells (DLD-1 and COLO205) were compared with those on Lonicera caerulea Anthocyanins (AL.cae) and Vaccinium myrtillus Anthocyanins (Av.myr), using cell viability assays, DNA electrophoresis and nuclear morphology assays.Results The optimum process of Av.uliextraction involved conditions of temperature 20℃, pH 2.0, and diatomaceous earth 1.0 g/50 g of fruit weight. Av.uli contained 5 main components: delphinidin (40.70±1.72)%, cyanidin (3.40±0.68)%,petunidin (17.70±0.54)%, peonidin (2.90±0.63)% and malvidin (35.50±1.11)%. The malvidin percentage was significantly higher (P <0.05) than it in Av.myr. Av.uli complied with a dose-dependent repression of cancer cell proliferation with an IC50 (50% inhibitory concentration) value of 50 μg/ml, and showed greater anticancer efficiency than AL. cae and Av. myr under the same cell treatment conditions. These observations were further supported by the results of nuclear assays.Conclusions The extraction protocol and conditions we used were effective for anthocyanin extraction. Av.uli could be a feasible practical research tool and a promising therapeutic source to suppress human colon or colorectal cancers.

  4. Structure of putative CutA1 from Homo sapiens determined at 2.05 Å resolution

    Energy Technology Data Exchange (ETDEWEB)

    Bagautdinov, Bagautdin, E-mail: bagautdi@spring8.or.jp; Matsuura, Yoshinori; Bagautdinova, Svetlana; Kunishima, Naoki; Yutani, Katsuhide [Protein Structure Analysis Team, RIKEN SPring-8 Center, Harima Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan)

    2008-05-01

    The X-ray structure of human CutA1 was solved in space group P2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = 68.69, b = 88.84, c = 125.33 Å and six molecules per asymmetric unit. The structure of human brain CutA1 (HsCutA1) has been determined using diffraction data to 2.05 Å resolution. HsCutA1 has been implicated in the anchoring of acetylcholinesterase in neuronal cell membranes, while its bacterial homologue Escherichia coli CutA1 is involved in copper tolerance. Additionally, the structure of HsCutA1 bears similarity to that of the signal transduction protein PII, which is involved in regulation of nitrogen metabolism. Although several crystal structures of CutA1 from various sources with different rotation angles and degrees of interaction between trimer interfaces have been reported, the specific functional role of CutA1 is still unclear. In this study, the X-ray structure of HsCutA1 was determined in space group P2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = 68.69, b = 88.84, c = 125.33 Å and six molecules per asymmetric unit. HsCutA1 is a trimeric molecule with intertwined antiparallel β-strands; each subunit has a molecular weight of 14.6 kDa and contains 135 amino-acid residues. In order to obtain clues to the possible function of HsCutA1, its crystal structure was compared with those of other CutA1 and PII proteins.

  5. Structure of putative CutA1 from Homo sapiens determined at 2.05 Å resolution

    International Nuclear Information System (INIS)

    The X-ray structure of human CutA1 was solved in space group P212121, with unit-cell parameters a = 68.69, b = 88.84, c = 125.33 Å and six molecules per asymmetric unit. The structure of human brain CutA1 (HsCutA1) has been determined using diffraction data to 2.05 Å resolution. HsCutA1 has been implicated in the anchoring of acetylcholinesterase in neuronal cell membranes, while its bacterial homologue Escherichia coli CutA1 is involved in copper tolerance. Additionally, the structure of HsCutA1 bears similarity to that of the signal transduction protein PII, which is involved in regulation of nitrogen metabolism. Although several crystal structures of CutA1 from various sources with different rotation angles and degrees of interaction between trimer interfaces have been reported, the specific functional role of CutA1 is still unclear. In this study, the X-ray structure of HsCutA1 was determined in space group P212121, with unit-cell parameters a = 68.69, b = 88.84, c = 125.33 Å and six molecules per asymmetric unit. HsCutA1 is a trimeric molecule with intertwined antiparallel β-strands; each subunit has a molecular weight of 14.6 kDa and contains 135 amino-acid residues. In order to obtain clues to the possible function of HsCutA1, its crystal structure was compared with those of other CutA1 and PII proteins

  6. Determining the Total Volume of the 2.05 Ga Bushveld Magmatic Event: Correlation of the Molopo Farms Complex, Botswana

    Science.gov (United States)

    Escobar, E.; Gates, M.; Pitcavage, E.; Bybee, G. M.; Feineman, M. D.

    2015-12-01

    The Bushveld Igneous Complex (BIC) in South Africa, erupted 2.05 billion years ago, is the world's largest layered intrusion in the range of 710-1060 x 103 km3 conservatively. However, the total volume of the magmatic event that produced the BIC remains poorly known. Several other intrusions occurred approximately contemporaneously with the BIC, but a clear relationship between these multiple intrusions is yet to be determined. The Molopo Farms Complex (MFC) is a layered igneous complex of similar age 2.044 Ga ­± 24 Ma located in Botswana, 200km west of the far western limb of the BIC, with a total volume of 1300 km2. Using trace element analysis, this study makes an attempt to find a correlation between the magma that emplaced the Molopo Farms Complex with the Bushveld Igneous Complex. The MFC is related to the BIC and is located under approximately 200m of Kalahari sands, which prevents any direct sampling or observation. Unlike the BIC, the MFC is poorly studied creating a lack of information for the complex. Drill core samples from the MFC were analyzed to determine the trace element composition using an inductively coupled plasma mass spectrometer (ICP-MS). Using previously reported values for the BIC; a comparison can be made on both complexes to find possible correlations. The comparison of trace element schematics in the MFC and the BIC suggest that both complexes are derived from the same parental magma, often referred to as the "B1" magma. These comparisons allow for an assumption that the initial parental magma of the BIC may have also emplaced the MFC.

  7. miRNA array analysis determines miR-205 is overexpressed in head and neck squamous cell carcinoma and enhances cellular proliferation

    Directory of Open Access Journals (Sweden)

    Howard JD

    2013-08-01

    Full Text Available MicroRNAs (miRNAs play a critical role in cell cycle and pro-survival signal regulation. Consequently, their deregulation can enhance tumorigenesis and cancer progression. In the current investigation, we determined whether cancer- or human papillomavirus (HPV-specific miRNA deregulation could further elucidate signal transduction events unique to head and neck squamous cell carcinoma (HNSCC. Twenty-nine newly diagnosed HNSCC tumors (HPV-positive: 14, HPV-negative: 15 and four normal mucosa samples were analyzed for global miRNA expression. Differential miRNA expression analysis concluded HNSCC is characterized by a general upregulation of miRNAs compared to normal mucosa. Additionally, miR-449a and miR-129-3p were statistically significant miRNAs differentially expressed between HPV-positive and HPV-negative HNSCC. The upregulation of miR-449a was also validated within an independent dataset obtained from TCGA containing 279 HNSCCs and 39 normal adjacent mucosa samples. To gain a better understanding of miRNA-mediated cell cycle deregulation in HNSCC, we functionally evaluated miR-205, a transcript upregulated in our cancer-specific analysis and a putative regulator of E2F1. Modulation of miR-205 with a miRNA mimic and inhibitor revealed miR-205 is capable of regulating E2F1 expression in HNSCC and overexpression of this transcript enhances proliferation. This study demonstrates miRNA expression is highly deregulated in HNSCC and functional evaluations of these miRNAs may reveal novel HPV context dependent mechanisms in this disease.

  8. Downregulation of COMMD1 by miR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cells.

    Science.gov (United States)

    Yeh, D-W; Chen, Y-S; Lai, C-Y; Liu, Y-L; Lu, C-H; Lo, J-F; Chen, L; Hsu, L-C; Luo, Y; Xiang, R; Chuang, T-H

    2016-05-01

    Sustained activation of nuclear factor-κB (NF-κB) in cancer cells has been shown to promote inflammation, expansion of cancer stem cell (CSC) population, and tumor development. In contrast, recent studies reveal that CSCs exhibit increased inflammation due to constitutive NF-κB activation; however, the underlying molecular mechanism remains unclear. In the present study, the analysis of microarray data revealed upregulation of NF-κB-regulated pro-inflammatory genes and downregulation of copper metabolism MURR1 domain-containing 1 (COMMD1) during the enrichment for stemness in SAS head and neck squamous-cell carcinoma (HNSCC) cells. The 3'-UTR of COMMD1 mRNA contains microRNA (miR)-205 target site. Parallel studies with HNSCC and NSCLC cells indicated that miR-205 is upregulated upon NF-κB activation and suppresses COMMD1 expression in stemness-enriched cancer cells. COMMD1 negatively regulates the inflammatory responses induced by TLR agonists, IL-1β, and TNF-α by targeting RelA for degradation. The shRNA-mediated downregulation of COMMD1 in cancer cells enhanced inflammatory response, generating favorable conditions for macrophage recruitment. In addition, genes associated with stemness were also upregulated in these cells, which exhibited increased potential for anchorage-independent growth. Furthermore, COMMD1 downregulation promoted in vivo tumorigenesis and tumor growth, and tumors derived from COMMD1-knockdown cells displayed elevated level of NF-κB activation, increased expression of inflammatory- and stemness-associated genes, and contain expanded population of tumor-associated leukocytes and stemness-enriched cancer cells. These results suggest that COMMD1 downregulation by miR-205 promotes tumor development by modulating a positive feedback loop that amplifies inflammatory- and stemness-associated properties of cancer cells. PMID:26586569

  9. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); ScientificOpinion on Flavouring Group Evaluation 205, (FGE.205): Consideration of genotoxicity data on representatives for 13 α,β-unsaturated aliphatic ketones with terminal double bonds and precursors from

    DEFF Research Database (Denmark)

    Larsen, John Christian; Nørby, Karin Kristiane; Beltoft, Vibe Meister;

    The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider in the Flavouring Group Evaluation 205, the additional data on genotoxicity submitted by the Industry on two representative substances, oct-1-en-3-one [FL...... on the first site of contact (e.g. the stomach) and on the liver is requested on the most potent of the representative substances, pent-1-en-3-one....

  10. Numerical Simulations of a 2.05 μm Q-switched Ho:YLF Laser for CO2 IPDA Space Remote Sensing

    OpenAIRE

    Pellegrino Jessica Barrientos; Edouart Dimitri; Gibert Fabien; Cenac Claire

    2016-01-01

    We report on numerical simulations of the performances of a 2.05 μm double pulse Q-switched Ho:YLF laser for the monitoring of CO2 from space. A Q-switched Holmium laser set-up based on a MOPA configuration is proposed to fulfill the requirements of a IPDA space-borne measurement. Double pulse operation is considered to obtain a 250 μs delay time between the ON and OFF pulse emissions. Numerical simulations results show that up to 40 mJ ON pulse can be extracted from the Ho:YLF laser at a rep...

  11. Survey of new vector computers: The CRAY 1S from CRAY research; the CYBER 205 from CDC and the parallel computer from ICL - architecture and programming

    Science.gov (United States)

    Gentzsch, W.

    1982-01-01

    Problems which can arise with vector and parallel computers are discussed in a user oriented context. Emphasis is placed on the algorithms used and the programming techniques adopted. Three recently developed supercomputers are examined and typical application examples are given in CRAY FORTRAN, CYBER 205 FORTRAN and DAP (distributed array processor) FORTRAN. The systems performance is compared. The addition of parts of two N x N arrays is considered. The influence of the architecture on the algorithms and programming language is demonstrated. Numerical analysis of magnetohydrodynamic differential equations by an explicit difference method is illustrated, showing very good results for all three systems. The prognosis for supercomputer development is assessed.

  12. Nondegenerate parametric generation of 2.2-mJ, few-cycle 2.05-μm pulses using a mixed phase matching scheme

    International Nuclear Information System (INIS)

    We describe the production of 2.2-mJ, ∼6 optical-cycle-long mid-infrared laser pulses with a carrier wavelength of 2.05 μm in a two-stage β-BaB2O4 nondegenerate optical parametric amplifier design with a mixed phase matching scheme, which is pumped by a standard Ti:sapphire chirped-pulse amplification system. It is demonstrated that relatively high pulse energies, short pulse durations, high stability, and excellent beam profiles can be obtained using this simple approach, even without the use of optical parametric chirped-pulse amplification

  13. Valve inlet fluid conditions for pressurizer safety and relief valves for B and W 177-FA and 205-FA plants. Final report. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    Cartin, L.R.; Winks, R.W.; Merchent, J.W.; Brandt, R.T.

    1982-12-01

    The overpressurization transients for the Babcock and Wilcox Company's 177- and 205-FA units are reviewed to determine the range of fluid conditions expected at the inlet of pressurizer safety and relief valves. The final Safety Analysis Report, extended high-pressure injection, and cold overpressurization events are considered. The results of this review, presented in the form of tables and graphs, provide input to the PWR utilities in their justification that the fluid conditions under which their valve designs were tested as part of the EPRI PWR Safety and Relief Valve Test Program are representative of those expected in their unit(s).

  14. 20.5.Epilepsy

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920390 Clinical analysis of 36 cases ofepilepsy in the elderly with cerebrovasculardiseases.SHI Shangjin (石尚金),et al.DeptNeurol,General Hosp,Guangzhou Milit Com-mand.Chin J Geriatr 1991;10(4):206-208.

  15. 20.5.Epilepsy

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920184 Clinical analysis of 25 cases ofchronic alcoholic intoxication with epilepsy.PANG Zhixing (庞治兴),et al.Dept Psychol,1stTeaching Hosp.Norman Bethune Med Univ,130021 Chin J Nerv & Ment Dis 1991; 17 (5):289-291.The clinical manifestations of 25 cases (male)

  16. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance.

    Science.gov (United States)

    Bonifaz, Laura; Bonnyay, David; Mahnke, Karsten; Rivera, Miguel; Nussenzweig, Michel C; Steinman, Ralph M

    2002-12-16

    To identify endocytic receptors that allow dendritic cells (DCs) to capture and present antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated DEC-205, which is abundant on DCs in lymphoid tissues. Ovalbumin (OVA) protein, when chemically coupled to monoclonal alphaDEC-205 antibody, was presented by CD11c+ lymph node DCs, but not by CD11c- cells, to OVA-specific, CD4+ and CD8+ T cells. Receptor-mediated presentation was at least 400 times more efficient than unconjugated OVA and, for MHC class I, the DCs had to express transporter of antigenic peptides (TAP) transporters. When alphaDEC-205:OVA was injected subcutaneously, OVA protein was identified over a 4-48 h period in DCs, primarily in the lymph nodes draining the injection site. In vivo, the OVA protein was selectively presented by DCs to TCR transgenic CD8+ cells, again at least 400 times more effectively than soluble OVA and in a TAP-dependent fashion. Targeting of alphaDEC-205:OVA to DCs in the steady state initially induced 4-7 cycles of T cell division, but the T cells were then deleted and the mice became specifically unresponsive to rechallenge with OVA in complete Freund's adjuvant. In contrast, simultaneous delivery of a DC maturation stimulus via CD40, together with alphaDEC-205:OVA, induced strong immunity. The CD8+ T cells responding in the presence of agonistic alphaCD40 antibody produced large amounts of interleukin 2 and interferon gamma, acquired cytolytic function in vivo, emigrated in large numbers to the lung, and responded vigorously to OVA rechallenge. Therefore, DEC-205 provides an efficient receptor-based mechanism for DCs to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation.

  17. Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

    Science.gov (United States)

    Bonifaz, Laura; Bonnyay, David; Mahnke, Karsten; Rivera, Miguel; Nussenzweig, Michel C.; Steinman, Ralph M.

    2002-01-01

    To identify endocytic receptors that allow dendritic cells (DCs) to capture and present antigens on major histocompatibility complex (MHC) class I products in vivo, we evaluated DEC-205, which is abundant on DCs in lymphoid tissues. Ovalbumin (OVA) protein, when chemically coupled to monoclonal αDEC-205 antibody, was presented by CD11c+ lymph node DCs, but not by CD11c− cells, to OVA-specific, CD4+ and CD8+ T cells. Receptor-mediated presentation was at least 400 times more efficient than unconjugated OVA and, for MHC class I, the DCs had to express transporter of antigenic peptides (TAP) transporters. When αDEC-205:OVA was injected subcutaneously, OVA protein was identified over a 4–48 h period in DCs, primarily in the lymph nodes draining the injection site. In vivo, the OVA protein was selectively presented by DCs to TCR transgenic CD8+ cells, again at least 400 times more effectively than soluble OVA and in a TAP-dependent fashion. Targeting of αDEC-205:OVA to DCs in the steady state initially induced 4–7 cycles of T cell division, but the T cells were then deleted and the mice became specifically unresponsive to rechallenge with OVA in complete Freund's adjuvant. In contrast, simultaneous delivery of a DC maturation stimulus via CD40, together with αDEC-205:OVA, induced strong immunity. The CD8+ T cells responding in the presence of agonistic αCD40 antibody produced large amounts of interleukin 2 and interferon γ, acquired cytolytic function in vivo, emigrated in large numbers to the lung, and responded vigorously to OVA rechallenge. Therefore, DEC-205 provides an efficient receptor-based mechanism for DCs to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation. PMID:12486105

  18. Decontamination and dismantlement of the building 200/205 pneumatic transfer tube at Argonne National Laboratory-East project final report.

    Energy Technology Data Exchange (ETDEWEB)

    Wiese, E. C.

    1998-12-11

    The Building 200/205 Pneumatic Transfer Tube D&D Project was directed toward the following goals: Remove any radioactive and hazardous materials associated with the transfer tube; Survey the transfer tube to identify any external contamination; Remove the transfer tube and package for disposal; Survey the soil and sand surrounding the transfer tube for any contamination; and Backfill the trench in which the tube sat and restore the area to its original condition. These goals had been set in order to eliminate the radiological and hazardous safety concerns inherent in the buried transfer tube and to allow, upon completion of the project, the removal of this project from the ANL-E action item list. The physical condition of the transfer tube and possible nuclear fuel samples lost in the tube were the primary areas of concern, while the exact location of the transfer tube was of secondary concern. ANL-E health physics technicians collected characterization data from the ends of the Building 200/205 pneumatic transfer tube in January 1998. The characterization surveys identified contamination to a level of 67,000 dpm (1,117 Bq) ({beta}/{gamma}) and 20,000 dpm (333 Bq) {alpha} smearable at the opening.

  19. The miR-200 family and miR-205 are repressed by Twist1 and concurrently silenced and DNA hypermethylated in invasive bladder cancer

    DEFF Research Database (Denmark)

    Wiklund, Erik Digman

    MicroRNAs (miRNA) are small non-coding RNAs commonly deregulated in cancer. The miR-200 family (miR-200a, -200b, -200c, -141 and -429) and miR-205 are encoded in three separate genomic loci and are frequently silenced in advanced cancer. The miR-200 family and miR-205 have been implicated in tumour...... invasion and metastasis by negatively regulating the transcriptional repressors of E-cadherin, ZEB1 and ZEB2. Loss of miR-200 expression leads to silencing of E-cadherin, thereby promoting epithelial to mesenchymal transition (EMT) and loss of cell adhesion. However, little is known about...... the transcriptional regulation of the miR-200s. Here we show that the three miR-200 loci are concurrently silenced and gain promoter hypermethylation in muscle invasive bladder tumors and undifferentiated bladder cell lines. Furthermore, we report that the mesoderm transcription factor Twist1 and miR-200 expression...

  20. Cytotoxicity and intracellular fate of PLGA and chitosan-coated PLGA nanoparticles in Madin-Darby bovine kidney (MDBK) and human colorectal adenocarcinoma (Colo 205) cells.

    Science.gov (United States)

    Trif, Mihaela; Florian, Paula E; Roseanu, Anca; Moisei, Magdalena; Craciunescu, Oana; Astete, Carlos E; Sabliov, Cristina M

    2015-11-01

    Polymeric nanoparticles (NPs) are known to facilitate intracellular uptake of drugs to improve their efficacy, with minimum bioreactivity. The goal of this study was to assess cellular uptake and trafficking of PLGA NPs and chitosan (Chi)-covered PLGA NPs in Madin-Darby bovine kidney (MDBK) and human colorectal adenocarcinoma (Colo 205) cells. Both PLGA and Chi-PLGA NPs were not cytotoxic to the studied cells at concentrations up to 2500 μg/mL. The positive charge conferred by the chitosan deposition on the PLGA NPs improved NPs uptake by MDBK cells. In this cell line, Chi-PLGA NPs colocalized partially with early endosomes compartment and showed a more consistent perinuclear localization than PLGA NPs. Kinetic uptake of PLGA NPs by Colo 205 was slower than that by MDBK cells, detected only at 24 h, exceeding that of Chi-PLGA NPs. This study offers new insights on NP interaction with target cells supporting the use of NPs as novel nutraceuticals/drug delivery systems in metabolic disorders or cancer therapy. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3599-3611, 2015.

  1. Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition.

    Science.gov (United States)

    Su, Chih-Ming; Lee, Wei-Hwa; Wu, Alexander T H; Lin, Yen-Kuang; Wang, Liang-Shun; Wu, Chih-Hsiung; Yeh, Chi-Tai

    2015-06-01

    Breast cancer is the leading cause of cancer-related deaths among females in economically developing countries. Greater than 95% of breast malignancies are of epithelial origin; the induction of epithelial-to-mesenchymal transition (EMT) has been shown to initiate the metastatic process in breast carcinoma and remains the key target for drug development. Here, we examine the anti-metastatic potential of pterostilbene in modulating EMT process in breast cancer cells both in vitro and in vivo. The differential invasive ability among MCF7, Hs578t and MDA-MB-231 breast cancer cell lines were closely correlated with the expression of EMT markers, determined by Western blots and Matrigel-coated transwells assay. Pterostilbene inhibited the migratory and invasive potential of triple-negative MDA-MB-231 and Hs578t cells, accompanied by the up-regulation of E-cadherin and down-regulation of Snail, Slug, vimentin and ZEB1. Mechanistic investigations revealed a significant up-regulation of miR-205, which resulted in the reduction of Src expression in pterostilbene-treated breast cancer cells. Importantly, pterostilbene suppressed tumor growth and metastasis in MDA-MB-231-bearing NOD/SCID mice by reducing Src/Fak signaling; this observation was consistent with the negative correlations between miR-205 and Src expression in both normal and malignant breast tissues. Our findings provide supports for the usage of pterostilbene as an inhibitor of EMT process and potential candidate for adjuvant therapy. PMID:25792283

  2. The spatially-resolved correlation between [NII] 205 {\\mu}m line emission and the 24 {\\mu}m continuum in nearby galaxies

    CERN Document Server

    Hughes, T M; Schirm, M R P; Parkin, T J; Wu, R; De Looze, I; Wilson, C D; Viaene, S; Bendo, G J; Boselli, A; Cormier, D; Ibar, E; Karczewski, O Ł; Lu, N; Spinoglio, L

    2016-01-01

    A correlation between the 24 {\\mu}m continuum and the [NII] 205 {\\mu}m line emission may arise if both quantities trace the star formation activity on spatially-resolved scales within a galaxy, yet has so far only been observed in the nearby edge-on spiral galaxy NGC 891. We therefore assess whether the [NII] 205 - 24 {\\mu}m emission correlation has some physical origin or is merely an artefact of line-of-sight projection effects in an edge-on disc. We search for the presence of a correlation in Herschel and Spitzer observations of two nearby face-on galaxies, M51 and M83, and the interacting Antennae galaxies NGC 4038 and 4039. We show that not only is this empirical relationship also observed in face-on galaxies, but also that the correlation appears to be governed by the star formation rate (SFR). Both the nuclear starburst in M83 and the merger-induced star formation in NGC 4038/9 exhibit less [NII] emission per unit SFR surface density than the normal star-forming discs. These regions of intense star for...

  3. Uso de redes neurais artificais na predição de valores genéticos para peso aos 205 dias em bovinos da raça Tabapuã

    OpenAIRE

    R.V. Ventura; Silva, M. A.; T.H. Medeiros; N.L. Dionello; F.E. Madalena; A.B. Fridrich; B.D. Valente; Santos, G.G.; L.S. Freitas; R.R. Wenceslau; V.P.S. Felipe; G.S.S. Corrêa

    2012-01-01

    Dados de 19240 animais Tabapuã, provenientes de 152 fazendas localizadas em diversos estados brasileiros, nascidos entre 1976 e 1995, foram utilizados para predição do valor genético do peso aos 205 dias de idade (VG_P205) por meio de redes neurais artificiais (RNAs) e usando o algoritmo LM - Levenberg Marquardt - para treinamento dos dados de entrada. Por se tratar de rede com aprendizado supervisionado, foram utilizados, como saída desejada, os valores genéticos preditos pelo BLUP para a ca...

  4. MicroRNA profiling in prostate cancer--the diagnostic potential of urinary miR-205 and miR-214.

    Directory of Open Access Journals (Sweden)

    Anvesha Srivastava

    Full Text Available Prostate cancer (PCa is the most common type of cancer in men in the United States, which disproportionately affects African American descents. While metastasis is the most common cause of death among PCa patients, no specific markers have been assigned to severity and ethnic biasness of the disease. MicroRNAs represent a promising new class of biomarkers owing to their inherent stability and resilience. In the present study, we investigated potential miRNAs that can be used as biomarkers and/or therapeutic targets and can provide insight into the severity and ethnic biasness of PCa. PCR array was performed in FFPE PCa tissues (5 Caucasian American and 5 African American and selected differentially expressed miRNAs were validated by qRT-PCR, in 40 (15 CA and 25 AA paired PCa and adjacent normal tissues. Significantly deregulated miRNAs were also analyzed in urine samples to explore their potential as non-invasive biomarker for PCa. Out of 8 miRNAs selected for validation from PCR array data, miR-205 (p<0.0001, mir-214 (p<0.0001, miR-221(p<0.001 and miR-99b (p<0.0001 were significantly downregulated in PCa tissues. ROC curve shows that all four miRNAs successfully discriminated between PCa and adjacent normal tissues. MiR-99b showed significant down regulation (p<0.01 in AA PCa tissues as compared to CA PCa tissues and might be related to the aggressiveness associated with AA population. In urine, miR-205 (p<0.05 and miR-214 (p<0.05 were significantly downregulated in PCa patients and can discriminate PCa patients from healthy individuals with 89% sensitivity and 80% specificity. In conclusion, present study showed that miR-205 and miR-214 are downregulated in PCa and may serve as potential non-invasive molecular biomarker for PCa.

  5. Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen

    Directory of Open Access Journals (Sweden)

    Saluja SS

    2014-11-01

    Full Text Available Sandeep S Saluja,1 Douglas J Hanlon,1 Fiona A Sharp,2 Enping Hong,2 David Khalil,1 Eve Robinson,1 Robert Tigelaar,1 Tarek M Fahmy,2,3 Richard L Edelson1 1Department of Dermatology, Yale University School of Medicine, 2Department of Biomedical Engineering, Yale University, 3Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA Abstract: Targeting antigen to dendritic cells (DCs is a powerful and novel strategy for vaccination. Priming or loading DCs with antigen controls whether subsequent immunity will develop and hence whether effective vaccination can be achieved. The goal of our present work was to increase the potency of DC-based antitumor vaccines by overcoming inherent limitations associated with antigen stability and cross-presentation. Nanoparticles prepared from the biodegradable polymer poly(lactic-co-glycolic acid have been extensively used in clinical settings for drug delivery and are currently the subject of intensive investigation as antigen delivery vehicles for vaccine applications. Here we describe a nanoparticulate delivery system with the ability to simultaneously carry a high density of protein-based antigen while displaying a DC targeting ligand on its surface. Utilizing a targeting motif specific for the DC-associated surface ligand DEC-205, we show that targeted nanoparticles encapsulating a MART-127–35 peptide are both internalized and cross-presented with significantly higher efficiency than isotype control-coated nanoparticles in human cells. In addition, the DEC-205-labeled nanoparticles rapidly escape from the DC endosomal compartment and do not colocalize with markers of early (EEA-1 or late endosome/lysosome (LAMP-1. This indicates that encapsulated antigens delivered by nanoparticles may have direct access to the class I cytoplasmic major histocompatibility complex loading machinery, overcoming the need for “classical” cross-presentation and facilitating heightened DC

  6. Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells

    Directory of Open Access Journals (Sweden)

    Hsiu-Man Lien

    2011-01-01

    Full Text Available A set of 10 4,7-dimethoxy-1,3-benzodioxole derivatives based on a lead compound previously discovered by our group, SY-1, which was isolated from Antrodia camphorata, were evaluated for their in vitro inhibitory activity on human colorectal carcinoma cells (COLO 205. Structure-activity relationship studies of the 10 compounds indicated the importance of the chain length of the alkyl group at the 5-position, and the 2-propenyl substituent named “apiole” exhibited the most potent inhibitory activity. In the present study, we demonstrate that the SY-1 analogue “apiole” decreased the proliferation of COLO 205 cells, but not that of normal human colonic epithelial cells (FHC. The G0/G1 cell cycle arrest induced by apiole (75–225 μM was associated with significantly increased levels of p53, p21 and p27 and decreased levels of cyclin D1. Concerning COLO 205 cell apoptosis, apiole (>150 μM treatment significantly increased the levels of cleaved caspases 3, 8, 9 and bax/bcl-2 ratio and induced ladder formation in DNA fragmentation assay and sub-G1 peak in flow cytometry analysis. These findings suggest that apiole can suppress COLO 205 cell growth; however, the detailed mechanisms of these processes require further investigation.

  7. Thermal-hydraulic design calculations for the annular fuel element with replaceable test bundles (TOAST) on the test zone position 205 of KNK II/3

    International Nuclear Information System (INIS)

    Annular fuel elements are foreseen in KNK II as carrier elements for irradiation inserts and test bundles. For the third core a reloadable annular element on position 205 is foreseen, in which replaceable 19-pin test bundles (TOAST) shall be irradiated. The present report deals with the thermal-hydraulic design of the annular carrier element and the test bundle, whereby the test bundle required additional optimization. The code CIA has been used for the calculations. Start of irradiation of the subassembly is planned at the beginning of the third core operation. After optimization of the pin-spacer geometry in the test bundle, design calculations for both bundles were performed, whereby thermal coupling between both was taken into account. The calculated mass-flows and temperature distributions are given for the nominal and the eccentric element configuration. The calculated bundle pressure losses have been corrected according to experimental results

  8. Microcalorimetric Studies on Gene Promoter Function of Cloned DNA Fragements from Halobacterium halobium J7 Plasmid pHH205 in Escherichia coli TG1

    Institute of Scientific and Technical Information of China (English)

    LEI,Ke-Lin; HOU,Han-Na; LIU,Yi; YE,Xue-Cheng; SHEN,Ping

    2007-01-01

    Halobacterium halobium is a typical kind of extremely halophilic bacterium. Combined with the antibiotic resistance assay, the microcalorimetric method was used to study the promoter function of the cloned DNA fragments from Halobacterium halobium J7 plasmid pHH205 in Escherichia coli TG1. The promoter probe vector, plasmid pKK232-8, was used to form the recombinants. The DNA fragment, which is the promoter for the chloramphenicol acetyl transferase (CAT) gene in plasmid pKK232-8, is about 800 bp, and the chloramphenicol resistance level presented by IC50 is about 200 μg·mL-1, which suggests a high promoter activity. The conclusions show that there probably exist double-function or trinary-function gene promoters in Halobacterium halobium, and Archaea may contain rich genetic resources.

  9. Numerical Simulations of a 2.05 μm Q-switched Ho:YLF Laser for CO2 IPDA Space Remote Sensing

    Science.gov (United States)

    Barrientos Pellegrino, Jessica; Edouart, Dimitri; Gibert, Fabien; Cenac, Claire

    2016-06-01

    We report on numerical simulations of the performances of a 2.05 μm double pulse Q-switched Ho:YLF laser for the monitoring of CO2 from space. A Q-switched Holmium laser set-up based on a MOPA configuration is proposed to fulfill the requirements of a IPDA space-borne measurement. Double pulse operation is considered to obtain a 250 μs delay time between the ON and OFF pulse emissions. Numerical simulations results show that up to 40 mJ ON pulse can be extracted from the Ho:YLF laser at a repetition rate of 350 Hz with an optical efficiency of 17 %.

  10. Lidar reflectance from snow at 2.05  μm wavelength as measured by the JPL Airborne Laser Absorption Spectrometer.

    Science.gov (United States)

    Spiers, Gary D; Menzies, Robert T; Jacob, Joseph C

    2016-03-10

    We report airborne measurements of lidar directional reflectance (backscatter) from land surfaces at a wavelength in the 2.05 μm CO₂ absorption band, with emphasis on snow-covered surfaces in various natural environments. Lidar backscatter measurements using this instrument provide insight into the capabilities of lidar for both airborne and future global-scale CO₂ measurements from low Earth orbit pertinent to the NASA Active Sensing of CO₂ Emissions over Nights, Days, and Seasons mission. Lidar measurement capability is particularly useful when the use of solar scattering spectroscopy is not feasible for high-accuracy atmospheric CO₂ measurements. Consequently, performance in high-latitude and winter season environments is an emphasis. Snow-covered surfaces are known to be dark in the CO₂ band spectral regions. The quantitative backscatter data from these field measurements help to elucidate the range of backscatter values that can be expected in natural environments. PMID:26974792

  11. Venus树脂修整切牙切端和关闭中切牙间隙205例临床体会

    Institute of Scientific and Technical Information of China (English)

    陈月来

    2010-01-01

    目的 观察维纳斯(Venus)树脂修复切矛切端缺损和关闭中切牙间隙中的美学效果.方法 对切牙切端缺损修复及直接在中切牙上贴面而加大中切牙牙体的方法关闭中切牙间隙,从而达到恢复功能和美容的目的.结果 205例病例经1~3年随访,满意率79.04%,基本满意11.63%,失败率9.33%.结论 维纳斯(Venus)树脂是一种较理想的切牙切端缺损修复和关闭中切牙间隙的材料.

  12. ESAT-6 Targeting to DEC205+ Antigen Presenting Cells Induces Specific-T Cell Responses against ESAT-6 and Reduces Pulmonary Infection with Virulent Mycobacterium tuberculosis.

    Directory of Open Access Journals (Sweden)

    Aarón Silva-Sánchez

    Full Text Available Airways infection with Mycobacterium tuberculosis (Mtb is contained mostly by T cell responses, however, Mtb has developed evasion mechanisms which affect antigen presenting cell (APC maturation/recruitment delaying the onset of Ag-specific T cell responses. Hypothetically, bypassing the natural infection routes by delivering antigens directly to APCs may overcome the pathogen's naturally evolved evasion mechanisms, thus facilitating the induction of protective immune responses. We generated a murine monoclonal fusion antibody (α-DEC-ESAT to deliver Early Secretory Antigen Target (ESAT-6 directly to DEC205+ APCs and to assess its in vivo effects on protection associated responses (IFN-γ production, in vivo CTL killing, and pulmonary mycobacterial load. Treatment with α-DEC-ESAT alone induced ESAT-6-specific IFN-γ producing CD4+ T cells and prime-boost immunization prior to Mtb infection resulted in early influx (d14 post-infection and increased IFN-γ+ production by specific T cells in the lungs, compared to scarce IFN-γ production in control mice. In vivo CTL killing was quantified in relevant tissues upon transferring target cells loaded with mycobacterial antigens. During infection, α-DEC-ESAT-treated mice showed increased target cell killing in the lungs, where histology revealed cellular infiltrate and considerably reduced bacterial burden. Targeting the mycobacterial antigen ESAT-6 to DEC205+ APCs before infection expands specific T cell clones responsible for early T cell responses (IFN-γ production and CTL activity and substantially reduces lung bacterial burden. Delivering mycobacterial antigens directly to APCs provides a unique approach to study in vivo the role of APCs and specific T cell responses to assess their potential anti-mycobacterial functions.

  13. A putative autonomous 20.5 kb-CACTA transposon insertion in an F3'H allele identifies a new CACTA transposon subfamily in Glycine max

    Directory of Open Access Journals (Sweden)

    Vodkin Lila

    2008-12-01

    Full Text Available Abstract Background The molecular organization of very few genetically defined CACTA transposon systems have been characterized thoroughly as those of Spm/En in maize, Tam1 of Antirrhinum majus Candystripe1 (Cs1 from Sorghum bicolor and CAC1 from Arabidopsis thaliana, for example. To date, only defective deletion derivatives of CACTA elements have been described for soybean, an economically important plant species whose genome sequence will be completed in 2008. Results We identified a 20.5 kb insertion in a soybean flavonoid 3'-hydroxylase (F3'H gene representing the t* allele (stable gray trichome color whose origin traces to a single mutable chimeric plant displaying both tawny and gray trichomes. This 20.5 kb insertion has the molecular structure of a putative autonomous transposon of the CACTA family, designated Tgmt*. It encodes a large gene that was expressed in two sister isolines (T* and tm of the stable gray line (t* from which Tgmt* was isolated. RT-PCR derived cDNAs uncovered the structure of a large precursor mRNA as well as alternatively spliced transcripts reminiscent of the TNPA-mRNA generated by the En-1 element of maize but without sequence similarity to the maize TNPA. The larger mRNA encodes a transposase with a tnp2 and TNP1-transposase family domains. Because the two soybean lines expressing Tgmt* were derived from the same mutable chimeric plant that created the stable gray trichome t* allele line from which the element was isolated, Tgmt* has the potential to be an autonomous element that was rapidly inactivated in the stable gray trichome t* line. Comparison of Tgmt* to previously described Tgm elements demonstrated that two subtypes of CACTA transposon families exist in soybean based on divergence of their characteristic subterminal repeated motifs and their transposases. In addition, we report the sequence and annotation of a BAC clone containing the F3'H gene (T locus which was interrupted by the novel Tgmt* element

  14. NITRATE + NITRITE CONTENT (CONCENTRATION), PHOSPHATE, NITRITE, SILICATE and other profile and discrete sample data collected in the Gulf of Alaska on the ALPHA HELIX and WECOMA cruises HX203, HX205 and others as part of the NEP project from 1998-03-08 to 2004-07-05 (NODC Accession 0115260)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0115260 includes profile, discrete sample and chemical data collected aboard the ALPHA HELIX and WECOMA during cruises HX203, HX205, HX208, HX211,...

  15. Curcumin intake affects miRNA signature in murine melanoma with mmu-miR-205-5p most significantly altered.

    Directory of Open Access Journals (Sweden)

    Indra N Dahmke

    Full Text Available Melanoma is the most aggressive form of skin cancer with estimated 48,000 deaths per year worldwide. The polyphenol curcumin derived from the plant Curcuma longa is well known for its anti-inflammatory and anti-cancerogenic properties. Accordingly, dietary intake of this compound may be suitable for melanoma prevention. However, how this compound affects basic cellular mechanisms in developing melanoma still remains elusive. Therefore, the aim of this study was to investigate for the first time the impact of oral curcumin administration on the miRNA signature of engrafting melanoma. For this purpose, the effects of a 4% curcumin diet were tested on melanoma, which were established by injection of murine B78H1 cells in the flank of C57BL/6 mice. Curcumin diet or standard chow (control was administered two weeks prior to injection of tumor cells until termination of the experiment. High throughput chip-based array analysis was deployed to detect alterations in the miRNA signature of the tumors. Curcumin treatment significantly reduced the growth of the flank tumors. Furthermore the miRNA expression signature in tumors was substantially altered by curcumin intake with mmu-miR-205-5p over 100 times higher expressed when compared to controls. The expression levels of identified key miRNAs in the tumor samples were confirmed by quantitative real-time polymerase chain reaction (qRT-PCR. A comparable expression pattern of these miRNAs was also detected in other curcumin-treated melanoma cell lines under in vitro conditions. Putative targets of curcumin-induced up-regulated miRNAs were enriched in 'o-glycan biosynthesis', 'endoplasmatic reticulum protein processing' and different cancer-related pathways. Western Blot analyses revealed that of these targets anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2 and proliferating cell nuclear antigen (PCNA were significantly down-regulated in curcumin-treated tumors. These findings demonstrate a profound alteration

  16. Relation between Partial Mechanical Injuries and Nature of Death in High-falling Cases:An Analysis of 205 Cases%205例高坠案件局部机械性损伤与死亡性质关系分析

    Institute of Scientific and Technical Information of China (English)

    王怀勇; 罗斌; 石河; 黄京璐; 李明; 张凯

    2015-01-01

    Objective To explore the relation between the behavior psychology analysis of partial me-chanical injuries and the nature of death in high-falling cases, and provide reference, for such cases. Methods Of 311 death victims of high-falling injuries collected from 2008 to 2013, 205 cases were as-sociated with partial mechanical injuries. The characteristics of injury formation, preliminary crime scene traces, fatal injury of high-falling, and text messages were all retrospectively analyzed. Results Accord-ing to the investigation of preliminary crime scene traces, fatal injury of high-falling and text message, there were 86 suicide, 24 accident and 95 uncertainty in the 205 cases. According to the behavior psy-chology analysis of partial mechanical injuries, there were 80 suicide, 11 accident, and 4 homicide in the 95 uncertainty cases. Conclusion The partial mechanical injuries uncertainly caused by high-falling correlate with the manner of high-falling death. According to the behavior psychology analysis of the partial mechanical injuries in high-falling death cases, the presumption of high-falling death is usually accurate.%目的:探讨高坠案件中局部机械性损伤行为心理分析与死亡性质的关系,为此类案件的定性提供参考。方法收集2008—2013年高坠死亡案件311例,其中存在高坠难以形成的局部机械性损伤案例205例。对损伤形成特点、现场痕迹、高坠致命伤、文字信息等进行分析。结果205例中,根据初步现场痕迹、高坠致命伤、文字信息等分析后,明确自杀86例,意外24例,性质不明95例。95例性质不明案例经对局部机械性损伤进行行为心理分析后,认定自杀80例,意外11例,他杀 4例。结论高坠难以形成的局部机械性损伤与死亡性质具有关联性,根据局部机械性损伤行为心理分析推断高坠死亡性质基本准确。

  17. Clinical Outcomes of Volume-Modulated Arc Therapy in 205 Patients with Nasopharyngeal Carcinoma: An Analysis of Survival and Treatment Toxicities.

    Directory of Open Access Journals (Sweden)

    Rui Guo

    Full Text Available To investigate the clinical efficacy and treatment toxicity of volume-modulated arc therapy (VMAT for nasopharyngeal carcinoma (NPC.205 VMAT-treated NPC patients from our cancer center were prospectively entrolled. All patients received 68-70 Gy irradiation based on the planning target volume of the primary gross tumor volume. Acute and late toxicities were graded according to the Common Terminology Criteria for Adverse Events v3.0 and Radiation Therapy Oncology Group Late Radiation Morbidity Scoring Criteria.The median follow-up period was 37.3 months (range, 6.3-45.1 months. The 3-year estimated local failure-free survival, regional failure-free survival, locoregional failure-free survival, distant metastasis-free survival, disease-free survival and overall survival were 95.5%, 97.0%, 94.0%, 92.1%, 86.8% and 97.0%, respectively. Cox regression analysis showed primary gross tumor volume, N stage and EBV-DNA to be independent predictors of VMAT outcomes (P < 0.05. The most common acute and late side effects were grade 2-3 mucositis (78% and xerostomia (83%, 61%, 34%, and 9% at 3, 6, 12 and 24 months after VMAT, respectively.VMAT for the primary treatment of NPC achieved very high locoregional control with a favorable toxicity profile. The time-saving benefit of VMAT will enable more patients to receive precision radiotherapy.

  18. 2n-emission from 205Pb* nucleus using clusterization approach at Ebeam˜14-20 MeV

    Science.gov (United States)

    Kaur, Amandeep; Sandhu, Kiran; Sharma, Manoj Kumar

    2016-05-01

    The dynamics involved in n-induced reaction with 204Pb target is analyzed and the decay of the composite system 205Pb* is governed within the collective clusterization approach of the Dynamical Cluster-decay Model (DCM). The experimental data for 2n-evaporation channel is available for neutron energy range of 14-20 MeV and is addressed by optimizing the only parameter of the model, the neck-length parameter (ΔR). The calculations are done by taking the quadrupole (β2) deformations of the decaying fragments and the calculated 2n-emission cross-sections find nice agreement with available data. An effort is made to study the role of level density parameter in the decay of hot-rotating nucleus, and the mass dependence in level density parameter is exercised for the first time in DCM based calculations. It is to be noted that the effect of deformation, temperature and angular momentum etc. is studied to extract better description of the dynamics involved.

  19. HATNet Field G205: Follow-Up Observations of 28 Transiting-Planet candidates and Confirmation of the Planet HAT-P-8b

    CERN Document Server

    Latham, David W; Torres, Guillermo; Stefanik, Robert P; Noyes, Robert W; Kovács, Géza; Pál, András; Marcy, Geoffrey W; Fischer, Debra A; Butler, R Paul; Sip\\H{o)cz, Brigitta; Sasselov, Dimitar D; Esquerdo, Gilbert A; Vogt, Steven S; Hartman, Joel D; Kovács, Gábor; Lázár, József; Papp, István; Sári, Pál

    2008-01-01

    We report the identification of 32 transiting-planet candidates in HATNet field G205. We describe the procedures that we have used to follow up these candidates with spectroscopic and photometric observations, and we present a status report on our interpretation of the 28 candidates for which we have follow-up observations. Eight are eclipsing binaries with orbital solutions whose periods are consistent with their photometric ephemerides; two of these spectroscopic orbits are singled-lined and six are double-lined. For one of the candidates, a nearby but fainter eclipsing binary proved to be the source for the HATNet light curve, due to blending in the HATNet images. Four of the candidates were found to be rotating more rapidly than vsini = 50 km/s and were not pursued further. Thirteen of the candidates showed no significant velocity variation at the level of 0.5 to 1.0 km/s . Seven of these were eventually withdrawn as photometric false alarms based on an independent reanalysis using more sophisticated tool...

  20. Medium optimization for the production of cyclic adenosine 3',5'-monophosphate by Microbacterium sp. no. 205 using response surface methodology.

    Science.gov (United States)

    Chen, Xiao-Chun; Bai, Jian-Xin; Cao, Jia-Ming; Li, Zhen-Jiang; Xiong, Jian; Zhang, Lei; Hong, Yuan; Ying, Han-Jie

    2009-01-01

    Response surface methodology was employed to optimize medium composition for the production of cyclic adenosine 3',5'-monophosphate (cAMP) with Microbacterium sp. no. 205. A fractional factorial design (2(11-7)) was applied to evaluate the effects of different components in the medium. K(2)HPO(4), MgSO(4) and NaF were found to significantly influence on the cAMP production. The steepest ascent method was used to access the optimal region of the medium composition. The concentrations of the three factors were optimized subsequently using central composite design and response surface methodology. The optimal medium composition to achieve the optimal cAMP production was determined (g/L): K(2)HPO(4), 12.78; MgSO(4), 3.53 and NaF, 0.18. The corresponding cAMP concentration was 8.50 g/L, which was about 1.8-fold increase compared with that using the original medium. Validation experiments were also carried out to prove the adequacy and the accuracy of the model obtained. The cAMP fermentation in 5L fermenter reached 9.87 g/L. PMID:18778935