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Sample records for astatine 204

  1. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  2. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  3. Adsorption interaction of astatine species with quartz and gold surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Serov, A. [Paul Scherrer Institute, Villigen (Switzerland). Lab. for Radiochemistry and Environmental Chemistry; Bern Univ. (Switzerland). Dept. for Chemistry and Biochemistry; Aksenov, N.; Bozhikov, G. [Joint Institute for Nuclear Research, Dubna (RU). Flerov Lab. of Nuclear Reactions] (and others)

    2011-07-01

    The adsorption interaction of various astatine species with quartz and gold surfaces was investigated by gas chromatography methods. Due to variations of the redox potential of the carrier gas elemental astatine, astatine oxide and hypo-astatic acid have been produced. The identification of the astatine compounds is based on the analogy assumption to the gas phase chemistry of the closest homologues in group 17 of the periodic table, iodine and bromine. The deposition temperatures as well as enthalpies of adsorption have been determined for the astatine species. The enhancement of the metallic character within group 17 towards higher Z is clearly confirmed. Macroscopic properties (sublimation enthalpy) of previously unstudied AtO{sub 2} and HAtO were estimated. The determined data for elemental astatine were compared to available literature data. Based on the obtained experimental results possible designs of experiments for studying of chemical properties of the recently discovered element 117 can be suggested. (orig.)

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. Discovery of the astatine, radon, francium, and radium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  6. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  7. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  8. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  9. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  10. 44 CFR 204.27-204.40 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false 204.27-204.40 Section 204.27-204.40 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE FIRE MANAGEMENT ASSISTANCE GRANT PROGRAM Declaration Process §§ 204.27-204.40...

  11. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  12. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom;

    2015-01-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...... and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting...... vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method...

  13. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  14. HIS 204 ASH Course Tutorial / Tutorialoutlet

    OpenAIRE

    JOHN

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com   HIS 204 Week 1 DQ 1 (Ash) HIS 204 Week 1 DQ 2 (Ash) HIS 204 Week 1 Quiz (Ash) HIS 204 Week 2 DQ 1 (Ash) HIS 204 Week 2 DQ 2 (Ash) HIS 204 Week 2 Quiz (Ash) HIS 204 Week 3 Assignment Women Right, Sacrifices & Independence (Ash) HIS 204 Week 3 DQ 1 (Ash) HIS 204 Week 3 DQ 2 (Ash) HIS 204 Week 4 DQ 1 (Ash) HIS 204 Week 4 DQ 2 (Ash) HIS 204 Week 4 Quiz (Ash) HIS 204 Week 5 DQ 1 (Ash) ...

  15. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  16. ONU 204i

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    ONU 204i是UTStarcom推出的一款用于GEPON系统的用户终端设备。它专为家庭用户和SOHO用户设计,为用户网关或PC提供千兆速率的宽带连接。ONU 204i位数据和IPTV视频服务提供了4路具备强大二层功能的10/100Base—T Ethernet网口.它可由UTStarcom BBS系列的光线路终端进行远端的配置和管理。

  17. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  18. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  19. HIS 204 NEW Course Tutorial / Tutorialoutlet

    OpenAIRE

    JOHN

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com   HIS 204 Week 1 DQ 1 The History of Reconstruction (Ash) (New) HIS 204 Week 1 DQ 2 The Industrial Revolution (Ash) (New) HIS 204 Week 1 Quiz (Ash) (New) HIS 204 Week 2 DQ 1 The Progressive Movement (Ash) (New) HIS 204 Week 2 DQ 2 America's Age of Imperialism (Ash) (New) HIS 204 Week 2 Quiz (Ash) (New) HIS 204 Week 2 Paper The Progressive Presidents (Ash) (New) HIS 204 Week 3 DQ 1 Normalcy and the...

  20. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  1. 48 CFR 3017.204 - Contracts.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contracts. 3017.204... ACQUISITION REGULATION (HSAR) CONTRACT METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options. 3017.204 Contracts....

  2. 30 CFR 204.204 - What accounting and auditing relief will MMS not allow?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What accounting and auditing relief will MMS not allow? 204.204 Section 204.204 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and Auditing...

  3. 48 CFR 18.204 - Resources.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Resources. 18.204 Section 18.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Emergency Acquisition Flexibilities 18.204 Resources. (a)...

  4. 48 CFR 217.204 - Contracts.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contracts. 217.204 Section... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 217.204 Contracts. (e)(i) Notwithstanding FAR 17.204(e), the ordering period of a task order or delivery order...

  5. 48 CFR 2017.204 - Contracts

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts 2017.204 Section 2017.204 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 2017.204 Contracts (a) The contracting officer...

  6. 48 CFR 317.204 - Contracts.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contracts. 317.204 Section 317.204 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 317.204 Contracts. (e) The total of the basic and...

  7. 48 CFR 1517.204 - Contracts.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts. 1517.204 Section 1517.204 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1517.204 Contracts. The SCM may approve a contract...

  8. 48 CFR 17.204 - Contracts.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contracts. 17.204 Section 17.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 17.204 Contracts. (a) The contract shall specify...

  9. 48 CFR 617.204 - Contracts.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contracts. 617.204 Section 617.204 Federal Acquisition Regulations System DEPARTMENT OF STATE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 617.204 Contracts. (e) The Procurement Executive shall...

  10. 48 CFR 817.204 - Contracts.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracts. 817.204 Section 817.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 817.204 Contracts. (a) The contracting officer...

  11. 42 CFR 93.204 - Contract.

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    2010-10-01

    ... MISCONDUCT Definitions § 93.204 Contract. Contract means an acquisition instrument awarded under the HHS Federal Acquisition Regulation (FAR), 48 CFR Chapter 1, excluding any small purchases awarded pursuant to... 42 Public Health 1 2010-10-01 2010-10-01 false Contract. 93.204 Section 93.204 Public...

  12. 48 CFR 2417.204 - Contracts.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts. 2417.204 Section 2417.204 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT CONTRACTING METHODS AND CONTRACTING TYPES SPECIAL CONTRACTING METHODS Options 2417.204 Contracts. (e) The...

  13. 48 CFR 417.204 - Contracts.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contracts. 417.204 Section 417.204 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 417.204 Contracts. The head of the contracting...

  14. 48 CFR 811.204 - Contract clause.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 811.204 Section 811.204 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS COMPETITION AND ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Using and Maintaining Requirements Documents 811.204...

  15. 32 CFR 204.4 - Responsibilities.

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    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 204.4 Section 204.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS USER FEES § 204.4 Responsibilities. (a) The USD(C) shall develop and monitor policies governing...

  16. 14 CFR 1212.204 - Fees.

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    2010-01-01

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  17. 40 CFR 243.204 - Collection management.

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    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Collection management. 243.204 Section 243.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.204 Collection management....

  18. 22 CFR 204.43 - Governing law.

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    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Governing law. 204.43 Section 204.43 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT HOUSING GUARANTY STANDARD TERMS AND CONDITIONS Administration § 204.43 Governing law. This Guaranty shall be governed by and construed in accordance with the laws...

  19. 22 CFR 204.41 - Arbitration.

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    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Arbitration. 204.41 Section 204.41 Foreign... § 204.41 Arbitration. Any controversy or claim between A.I.D. and the Lender or any Assignee arising out of this Guaranty shall be settled by arbitration to be held in Washington, DC in accordance with...

  20. 40 CFR 240.204-1 - Requirement.

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    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirement. 240.204-1 Section 240.204-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.204-1...

  1. 48 CFR 204.802 - Contract files.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract files. 204.802 Section 204.802 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Files 204.802 Contract files. Official...

  2. 46 CFR 204.10 - Attorney's fees.

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    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Attorney's fees. 204.10 Section 204.10 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION POLICY, PRACTICE AND PROCEDURE CLAIMS AGAINST THE MARITIME ADMINISTRATION UNDER THE FEDERAL TORT CLAIMS ACT § 204.10 Attorney's fees. Attorney's fees for any claim...

  3. 7 CFR 1430.204 - Requesting benefits.

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    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Requesting benefits. 1430.204 Section 1430.204... Program § 1430.204 Requesting benefits. (a) A request for benefits or contract application, under this... MILC benefits must certify the accuracy and truthfulness of the information in their...

  4. 22 CFR 20.4 - Retirement benefits.

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    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Retirement benefits. 20.4 Section 20.4 Foreign Relations DEPARTMENT OF STATE PERSONNEL BENEFITS FOR CERTAIN FORMER SPOUSES § 20.4 Retirement benefits. (a) Type of benefits. (1) A former spouse who meets the qualification requirements of § 20.3 is entitled...

  5. 48 CFR 243.204 - Administration.

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    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders....

  6. 40 CFR 240.204 - Water quality.

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    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Water quality. 240.204 Section 240.204 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.204 Water quality....

  7. Dicty_cDB: CHR204 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHR204 (Link to dictyBase) - - - Contig-U16471-1 CHR204P (Link to Original site) CHR...204F 167 CHR204Z 819 CHR204P 966 - - Show CHR204 Library CH (Link to library) Clone ID CHR... URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CH/CHR2-A/CHR204Q.Seq.d/ Representative seq. ID CHR...204P (Link to Original site) Representative DNA sequence >CHR204 (CHR204Q) /CSM/CH/CHR2-A/CHR2... significant alignments: (bits) Value CHR204 (CHR204Q) /CSM/CH/CHR2-A/CHR204Q.Seq

  8. Dicty_cDB: CHG204 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHG204 (Link to dictyBase) - - - Contig-U16708-1 CHG204P (Link to Original site) CHG20...4F 160 CHG204Z 479 CHG204P 619 - - Show CHG204 Library CH (Link to library) Clone ID CHG20... URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CH/CHG2-A/CHG204Q.Seq.d/ Representative seq. ID CHG20...4P (Link to Original site) Representative DNA sequence >CHG204 (CHG204Q) /CSM/CH/CHG2-A/CHG20... alignments: (bits) Value CHG204 (CHG204Q) /CSM/CH/CHG2-A/CHG204Q.Seq.d/ 876 0.0 VHA360 (VHA360Q) /CSM/VH/VH

  9. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  10. 9 CFR 204.1 - Introduction.

    Science.gov (United States)

    2010-01-01

    ... Introduction. The Grain Inspection, Packers and Stockyards Administration (Packers and Stockyards Programs... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Introduction. 204.1 Section 204.1 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS...

  11. 13 CFR 500.204 - Loan terms.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Loan terms. 500.204 Section 500... GUARANTEED LOAN PROGRAM Oil and Gas Guaranteed Loans § 500.204 Loan terms. (a) All loans guaranteed under the... United States with remaining periods of maturity comparable to the term of the loan sought to...

  12. 13 CFR 400.204 - Loan terms.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Loan terms. 400.204 Section 400... PROGRAM Steel Guarantee Loans § 400.204 Loan terms. (a) All loans guaranteed under the Program shall be... States with remaining periods of maturity comparable to the term of the loan sought to be guaranteed....

  13. 48 CFR 1817.204 - Contracts.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contracts. 1817.204 Section... CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Options 1817.204 Contracts. (e)(i) The 5-year limitation (basic plus option periods) applies to all NASA contracts regardless of type and...

  14. 17 CFR 204.6 - Agency review.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Agency review. 204.6 Section... COLLECTION Administrative Offset § 204.6 Agency review. (a) To the extent that a debt owed has not been... request to review a disputed debt must be submitted to the Commission official who provided...

  15. 48 CFR 44.204 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... contract, awarded on the basis of adequate price competition or whose prices are set by law or regulation... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clauses. 44.204 Section 44.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT...

  16. 9 CFR 204.2 - Organization.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Organization. 204.2 Section 204.2 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND..., Wyoming) Fort Worth—Room 8A36, Federal Building, 819 Taylor Street, Fort Worth, Texas 76102...

  17. 28 CFR 36.204 - Administrative methods.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Administrative methods. 36.204 Section 36... PUBLIC ACCOMMODATIONS AND IN COMMERCIAL FACILITIES General Requirements § 36.204 Administrative methods... standards or criteria or methods of administration that have the effect of discriminating on the basis...

  18. 17 CFR 204.75 - Collection services.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Collection services. 204.75... DEBT COLLECTION Miscellaneous: Credit Bureau Reporting, Collection Services § 204.75 Collection services. Section 13 of the Debt Collection Act (31 U.S.C. 3718) authorizes agencies to enter...

  19. 41 CFR 50-204.67 - Oxygen.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Oxygen. 50-204.67 Section..., Vapors, Fumes, Dusts, and Mists § 50-204.67 Oxygen. The in-plant transfer, handling, storage, and utilization of oxygen as a liquid or a compressed gas shall be in accordance with Compressed Gas...

  20. 44 CFR 204.1 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... information on the procedures for the declaration and grants management processes for the Fire Management... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 204.1 Section 204.1 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND...

  1. 50 CFR 648.204 - Possession restrictions.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Possession restrictions. 648.204 Section... Atlantic Herring Fishery § 648.204 Possession restrictions. (a) A vessel must be issued a valid limited... with no possession restriction from any of the herring management areas defined in §...

  2. 48 CFR 2052.204-70 - Security.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Security. 2052.204-70... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 2052.204-70 Security. As prescribed... National Security information, restricted data, formerly restricted data, and other classified...

  3. 41 CFR 50-204.68 - Hydrogen.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Hydrogen. 50-204.68..., Vapors, Fumes, Dusts, and Mists § 50-204.68 Hydrogen. The in-plant transfer, handling, storage, and utilization of hydrogen shall be in accordance with Compressed Gas Association Pamphlets G-5.1-1961 and...

  4. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  5. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  6. 41 CFR 50-204.36 - Radiation standards for mining.

    Science.gov (United States)

    2010-07-01

    .... Department of Labor, Radiation Safety and Health Standards (41 CFR 50-204.36). You should preserve this... mining. 50-204.36 Section 50-204.36 Public Contracts and Property Management Other Provisions Relating to... CONTRACTS Radiation Standards § 50-204.36 Radiation standards for mining. (a) For the purpose of...

  7. AcEST: CL204Contig1 [AcEST

    Lifescience Database Archive (English)

    Full Text Available CL204Contig1 503 2 Adiantum capillus-veneris contig: CL204contig1 sequence. Link to clone list Show CL2...04Contig1 Contig ID CL204Contig1 Length 503 Number of clones 2 Definition Adiantum capillus-veneris contig: CL2

  8. 12 CFR 204.121 - Bankers' banks.

    Science.gov (United States)

    2010-01-01

    ... D (12 CFR 204.3(i)) and if the Federal Reserve is satisfied that the quality of management and...-through correspondent in accordance with Regulation D. Satisfaction of these criteria will assure...

  9. Dicty_cDB: SSA204 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA204 (Link to dictyBase) - - - Contig-U14136-1 SSA204F (Link to Original site) SSA...204F 277 - - - - - - Show SSA204 Library SS (Link to library) Clone ID SSA204 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SS/SSA2-A/SSA204Q.Seq.d/ Representative seq. ID SSA20...4F (Link to Original site) Representative DNA sequence >SSA204 (SSA204Q) /CSM/SS/SSA2-A/SSA204Q.Seq.d/ AAAAT...vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SSA484 (SSA484Q) /CSM/SS/SSA

  10. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  11. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  12. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  13. 23 CFR 230.204 - Implementation of supportive services.

    Science.gov (United States)

    2010-04-01

    ... 230.204 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS EXTERNAL PROGRAMS Supportive Services for Minority, Disadvantaged, and Women Business Enterprises § 230.204... highway agency shall establish procedures to develop, conduct, and administer minority business...

  14. 22 CFR 204.1 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... “Act”). (b) Eligible Note(s) means (a) Note(s) meeting the eligiblity criteria set out in § 204.12...) Lender means an Eligible Investor who initially provides loan funds to the Borrower in exchange for... date on which banks of the District of Columbia of the United States of America are open for...

  15. 8 CFR 204.301 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... Intercountry Adoption of a Convention Adoptee § 204.301 Definitions. The definitions in 22 CFR 96.2 apply to... parent has willfully forsaken all parental rights, obligations, and claims to the child, as well as all... employee of the Central Authority (but not of an agency or entity authorized to perform a Central...

  16. 10 CFR 63.204 - Preclosure standard.

    Science.gov (United States)

    2010-01-01

    ... MOUNTAIN, NEVADA Preclosure Public Health and Environmental Standards § 63.204 Preclosure standard. DOE... of 0.15 mSv (15 mrem) from the combination of: (a) Management and storage (as defined in 40 CFR 191.2) of radioactive material that: (1) Is subject to 40 CFR 191.3(a); and (2) Occurs outside of the...

  17. 48 CFR 50.204 - Policy.

    Science.gov (United States)

    2010-10-01

    ... EXTRAORDINARY CONTRACTUAL ACTIONS AND THE SAFETY ACT Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.204 Policy. (a) Agencies should— (1) Determine whether the technology to be procured is...)(viii) of 6 CFR 25.4, Designation of Qualified Anti-Terrorism Technologies; (2) Encourage offerors...

  18. 41 CFR 109-50.204 - Limitations.

    Science.gov (United States)

    2010-07-01

    ... Condition Codes 1 and 4, as defined in 41 CFR 101-43.4801(e), meet this criteria. Serviceability of... DISPOSAL AUTHORITIES 50.2-Math and Science Equipment Gift Program § 109-50.204 Limitations. (a) Excess and... the appropriate gift instrument where the book value of an item of equipment exceeds $25,000 or...

  19. 32 CFR 204.7 - Legislative proposals.

    Science.gov (United States)

    2010-07-01

    ...) MISCELLANEOUS USER FEES § 204.7 Legislative proposals. (a) Legislative proposals that allow the DoD Component to..., if a provision of the service is dependent on demand that is irregular or unpredictable (e.g., a fee... Counsel, 1600 Defense Pentagon, Washington, DC 20301-1600. Proposals to remove user fee restrictions...

  20. 41 CFR 50-204.8 - Use of compressed air.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Use of compressed air. 50-204.8 Section 50-204.8 Public Contracts and Property Management Other Provisions Relating to Public... General Safety and Health Standards § 50-204.8 Use of compressed air. Compressed air shall not be used...

  1. 7 CFR 22.204 - Rural development committees.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Rural development committees. 22.204 Section 22.204 Agriculture Office of the Secretary of Agriculture RURAL DEVELOPMENT COORDINATION Roles and Responsibilities of Federal Government § 22.204 Rural development committees. State rural development...

  2. 7 CFR 3560.204 - Security deposits and membership fees.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Security deposits and membership fees. 3560.204 Section 3560.204 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Rents § 3560.204 Security deposits and membership fees. (a)...

  3. 32 CFR 204.3 - Policy and procedures.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Policy and procedures. 204.3 Section 204.3...) MISCELLANEOUS USER FEES § 204.3 Policy and procedures. (a) General. It is DoD policy not to compete unfairly... immediate or substantial gain or values (which may or may not be measurable in monetary terms) than...

  4. 40 CFR 86.204-94 - Section numbering; construction.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Section numbering; construction. 86.204-94 Section 86.204-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.204-94 Section...

  5. 5 CFR 179.204 - Applicability of regulations.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Applicability of regulations. 179.204 Section 179.204 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Salary Offset § 179.204 Applicability of regulations. These regulations are to...

  6. 48 CFR 204.804 - Closeout of contract files.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Closeout of contract files. 204.804 Section 204.804 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Files 204.804 Closeout of contract...

  7. 48 CFR 204.805 - Disposal of contract files.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Disposal of contract files. 204.805 Section 204.805 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Files 204.805 Disposal of contract files....

  8. 12 CFR 204.8 - International banking facilities.

    Science.gov (United States)

    2010-01-01

    ... specified in 12 CFR 204.125. (ii) (A) That is payable (1) On a specified date not less than two business... 12 Banks and Banking 2 2010-01-01 2010-01-01 false International banking facilities. 204.8 Section 204.8 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE...

  9. 44 CFR 204.21 - Fire management assistance declaration criteria.

    Science.gov (United States)

    2010-10-01

    ... Declaration Process § 204.21 Fire management assistance declaration criteria. (a) Determinations. We will... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Fire management assistance declaration criteria. 204.21 Section 204.21 Emergency Management and Assistance FEDERAL EMERGENCY...

  10. 42 CFR 56.204 - Grant evaluation and award.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Grant evaluation and award. 56.204 Section 56.204 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR MIGRANT HEALTH SERVICES Grants for Planning and Developing Migrant Health Centers § 56.204 Grant evaluation...

  11. 40 CFR 204.57 - Selective enforcement auditing.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Selective enforcement auditing. 204.57 Section 204.57 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS NOISE EMISSION STANDARDS FOR CONSTRUCTION EQUIPMENT Portable Air Compressors § 204.57 Selective enforcement...

  12. 40 CFR 204.3 - Number and gender.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Number and gender. 204.3 Section 204.3... STANDARDS FOR CONSTRUCTION EQUIPMENT General Provisions § 204.3 Number and gender. As used in this part, words in the singular shall be deemed to import the plural, and words in the masculine gender shall...

  13. 23 CFR 971.204 - Management systems requirements.

    Science.gov (United States)

    2010-04-01

    ... requirements of this subpart consistent with 23 CFR 660.105(b). The management systems may be tailored to meet... 23 Highways 1 2010-04-01 2010-04-01 false Management systems requirements. 971.204 Section 971.204... MANAGEMENT SYSTEMS Forest Highway Program Management Systems § 971.204 Management systems requirements....

  14. 23 CFR 973.204 - Management systems requirements.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Management systems requirements. 973.204 Section 973.204... Indian Affairs Management Systems § 973.204 Management systems requirements. (a) The BIA, in consultation... maximum extent possible to meet the management system requirements. (i) A nationwide congestion...

  15. 5 CFR 734.204 - Participation in political organizations.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Participation in political organizations. 734.204 Section 734.204 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL... participate fully in the business of nominating caucuses of political parties; (d) Organize or reorganize...

  16. 14 CFR 1214.204 - Patent and data rights.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Patent and data rights. 1214.204 Section... Substantial Investment in the STS Program § 1214.204 Patent and data rights. (a) When accommodating missions... purposes rights to inventions, patents and data resulting from such missions, subject to the...

  17. 5 CFR 2638.204 - Deputy ethics official.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Deputy ethics official. 2638.204 Section 2638.204 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Designated Agency Ethics Official §...

  18. 12 CFR 204.132 - Treatment of loan strip participations.

    Science.gov (United States)

    2010-01-01

    ... selling the loan or participation in effect must buy back the loan or participation at the maturity of the... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Treatment of loan strip participations. 204.132... RESERVE REQUIREMENTS OF DEPOSITORY INSTITUTIONS (REGULATION D) Interpretations § 204.132 Treatment of...

  19. 15 CFR 2011.204 - Entry of specialty sugars.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Entry of specialty sugars. 2011.204... UNITED STATES TRADE REPRESENTATIVE ALLOCATION OF TARIFF-RATE QUOTA ON IMPORTED SUGARS, SYRUPS AND MOLASSES Specialty Sugar § 2011.204 Entry of specialty sugars. An importer or the importer's agent...

  20. 41 CFR 50-204.1a - Variances.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Variances. 50-204.1a... and Application § 50-204.1a Variances. (a) Variances from standards in this part may be granted in the same circumstances in which variances may be granted under sections 6(b)(6)(A) or 6(d) of the...

  1. 48 CFR 52.204-2 - Security Requirements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Security Requirements. 52.204-2 Section 52.204-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Contractor agrees to insert terms that conform substantially to the language of this clause, including...

  2. 20 CFR 416.204 - Redeterminations of SSI eligibility.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Redeterminations of SSI eligibility. 416.204... AGED, BLIND, AND DISABLED Eligibility General § 416.204 Redeterminations of SSI eligibility. (a... eligible and that you are receiving the right amount of SSI benefits. This review deals with...

  3. 34 CFR 300.204 - Exception to maintenance of effort.

    Science.gov (United States)

    2010-07-01

    ... the child has terminated; or (3) No longer needs the program of special education. (d) The termination....204 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL... CHILDREN WITH DISABILITIES Local Educational Agency Eligibility § 300.204 Exception to maintenance...

  4. 48 CFR 204.7003 - Basic PII number.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Basic PII number. 204.7003 Section 204.7003 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT...), the National Industries for the Severely Handicapped (NISH), and the Federal Prison Industries...

  5. 8 CFR 204.302 - Role of service providers.

    Science.gov (United States)

    2010-01-01

    ... facilitator that is not authorized under 8 CFR part 292 to engage in representation before USCIS. (c... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Role of service providers. 204.302 Section... PETITIONS Intercountry Adoption of a Convention Adoptee § 204.302 Role of service providers. (a) Who...

  6. 23 CFR 810.204 - Application by mass transit authority.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Application by mass transit authority. 810.204 Section... MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass Transit Projects § 810.204 Application by mass transit authority. A publicly-owned mass transit authority...

  7. 48 CFR 204.270 - Electronic Document Access.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Contract Distribution 204.270 Electronic Document Access. Follow the procedures at PGI 204.270 relating to obtaining an account in the Electronic Document Access... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Electronic Document...

  8. 41 CFR 50-204.10 - Occupational noise exposure.

    Science.gov (United States)

    2010-07-01

    ... Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 204-SAFETY AND HEALTH STANDARDS FOR FEDERAL SUPPLY CONTRACTS General Safety and Health Standards § 50-204.10 Occupational noise exposure. (a) Protection... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Occupational...

  9. 6 CFR 27.204 - Minimum concentration by security issue.

    Science.gov (United States)

    2010-01-01

    ... the incorporation by reference of this standard in accordance with 5 U.S.C. 552(a) and 1 CFR part 51... 6 Domestic Security 1 2010-01-01 2010-01-01 false Minimum concentration by security issue. 27.204... FACILITY ANTI-TERRORISM STANDARDS Chemical Facility Security Program § 27.204 Minimum concentration...

  10. 40 CFR 600.204-77 - Section numbering, construction.

    Science.gov (United States)

    2010-07-01

    ....204-77 Section 600.204-77 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later Model Year Automobiles-Procedures for Calculating Fuel Economy Values §...

  11. 18 CFR 375.204 - Notice of meetings.

    Science.gov (United States)

    2010-04-01

    ....204 Section 375.204 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REVISED GENERAL RULES THE COMMISSION Procedures Under the Government in the Sunshine Act... Commission determines by a recorded vote by a majority of the membership that Commission business so...

  12. 7 CFR 25.204 - Evaluation of the strategic plan.

    Science.gov (United States)

    2010-01-01

    ... development—(1) Consolidated planning. The extent to which the plan is part of a larger strategic community... 7 Agriculture 1 2010-01-01 2010-01-01 false Evaluation of the strategic plan. 25.204 Section 25... COMMUNITIES Nomination Procedure § 25.204 Evaluation of the strategic plan. The strategic plan will...

  13. 48 CFR 952.204-77 - Computer security.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Computer security. 952.204... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.204-77 Computer security. As prescribed in 904.404(d)(7), the following clause shall be included: Computer Security (AUG 2006)...

  14. 7 CFR 400.204 - Notification of deviation from standards.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Notification of deviation from standards. 400.204... Contract-Standards for Approval § 400.204 Notification of deviation from standards. A Contractor shall advise the Corporation immediately if the Contractor deviates from the requirements of these...

  15. 5 CFR 870.204 - Annual rates of pay.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Annual rates of pay. 870.204 Section 870.204 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS... for an employee on piecework rates is the total basic earnings for the previous calendar year,...

  16. 23 CFR 972.204 - Management systems requirements.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Management systems requirements. 972.204 Section 972.204... systems requirements. (a) The FWS shall develop, establish and implement the management systems as... management system requirements. (f) The FWS shall develop an appropriate means to evaluate the...

  17. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  18. 48 CFR 3003.204 - Treatment of violations.

    Science.gov (United States)

    2010-10-01

    ... COCO shall ensure that the hearing procedures required by (FAR) 48 CFR 3.204(b) are afforded to the... during the “conduct of an agency procurement” the COCO shall consult with Government legal...

  19. 29 CFR 1603.204 - Ex parte communications.

    Science.gov (United States)

    2010-07-01

    ... EXEMPT STATE AND LOCAL GOVERNMENT EMPLOYEE COMPLAINTS OF EMPLOYMENT DISCRIMINATION UNDER SECTION 304 OF THE GOVERNMENT EMPLOYEE RIGHTS ACT OF 1991 Hearings § 1603.204 Ex parte communications. (a) Oral...

  20. Emergence of OXA-204 β-lactamase in Tunisia.

    Science.gov (United States)

    Charfi, Karama; Mansour, Wejdène; Khalifa, Anis Ben Haj; Mastouri, Maha; Aouni, Mahjoub; Mammeri, Hedi

    2015-08-01

    A retrospective epidemiological survey was carried out to determine the prevalence of carbapenemase producers among enterobacterial clinical isolates recovered in the center of maternity and neonatology of Monastir (Tunisia). PCR screening identified 1 OXA-48 and 2 OXA-204 producers, which coexpressed the CTX-M-15 or the CMY-4 β-lactamases. PCR mapping showed that the bla(OXA-48) gene was carried by a Tn1999.2 transposon, whereas the bla(OXA-204) gene was part of the Tn2016 transposon-like structure. The OXA-48- or OXA-204-producing Klebsiella pneumoniae clinical isolates and the OXA-204-expressing Escherichia coli clinical isolate belonged to the widespread sequence types ST11, ST101, and ST617, respectively. The OXA-204 enzyme, which is a point derivative of the OXA-48 carbapenemase, had hitherto been reported in 2013 from K. pneumoniae isolate. Our study shows for the first time the dissemination of this resistance marker in E. coli strain. The coproduction of OXA-204 with CTX-M-15 and CMY-4 enzymes may potentiate the risk of multiresistance and may enhance the risk of dissemination. PMID:26001616

  1. 40 CFR 94.204 - Designation of engine families.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Designation of engine families. 94.204... Designation of engine families. This section specifies the procedure and requirements for grouping of engines into engine families. (a) Manufacturers shall divide their engines into groupings of engines which...

  2. 5 CFR 847.204 - Elections of FERS coverage.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Elections of FERS coverage. 847.204... REGULATIONS (CONTINUED) ELECTIONS OF RETIREMENT COVERAGE BY CURRENT AND FORMER EMPLOYEES OF NONAPPROPRIATED FUND INSTRUMENTALITIES Elections To Continue Retirement Coverage After a Qualifying Move §...

  3. 31 CFR 537.204 - Prohibited new investment in Burma.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Prohibited new investment in Burma... Prohibitions § 537.204 Prohibited new investment in Burma. Except as otherwise authorized, new investment, as... Foreign Operations, Export Financing, and Related Programs Appropriations Act, 1997 (Public Law...

  4. 40 CFR 204.56 - Testing by the Administrator.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Testing by the Administrator. 204.56... the Administrator. (a)(1) The Administrator may require that any compressor tested or scheduled to be...) The Administrator may specify that he will conduct such testing at the manufacturer's facility,...

  5. 48 CFR 503.204 - Treatment of violations.

    Science.gov (United States)

    2010-10-01

    ... Executive, or designee, written findings of fact (together with a transcription of the proceedings, if made... mitigating factors to the Senior Procurement Executive, or designee, in accordance with FAR 3.204(b) either...(c) only after considering mitigating factors....

  6. 48 CFR 6.204 - Section 8(a) competition.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Section 8(a) competition... ACQUISITION PLANNING COMPETITION REQUIREMENTS Full and Open Competition After Exclusion of Sources 6.204 Section 8(a) competition. (a) To fulfill statutory requirements relating to section 8(a) of the...

  7. 48 CFR 952.204-73 - Facility clearance.

    Science.gov (United States)

    2010-10-01

    ..., control or influence and will be treated by DOE, to the extent permitted by law, as business or financial... agency, or representative of a foreign government; (ii) Any form of business enterprise or legal entity... FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 952.204-73...

  8. 48 CFR 204.7004 - Supplementary PII numbers.

    Science.gov (United States)

    2010-10-01

    ...) Positions 2 through 3. These are the first two digits in a serial number. They may be either alpha or... the office identified in the basic PII number, assign a serial number to the order or call. The first... Identification Numbers 204.7004 Supplementary PII numbers. (a) Uses of the supplementary number....

  9. 9 CFR 113.204 - Mink Enteritis Vaccine, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Mink Enteritis Vaccine, Killed Virus..., DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.204 Mink Enteritis Vaccine, Killed Virus. Mink Enteritis...

  10. 8 CFR 204.6 - Petitions for employment creation aliens.

    Science.gov (United States)

    2010-01-01

    ... subpart), and personal tax returns including income, franchise, property (whether real, personal, or... Management and Budget) or the outer boundary of any city or town having a population of 20,000 or more... this manner does not exempt the petitioner from the requirements of 8 CFR 204.6(j) (2) and (3)...

  11. 48 CFR 16.204 - Fixed-price incentive contracts.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Fixed-price incentive... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 16.204 Fixed-price incentive contracts. A fixed-price incentive contract is a fixed-price contract that provides for adjusting profit...

  12. 10 CFR 490.204 - Process for granting exemptions.

    Science.gov (United States)

    2010-01-01

    ... Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.204 Process for granting exemptions. (a) To obtain an exemption, in whole or in part...) Alternative fuels that meet the normal requirements and practices of the principal business of the State...

  13. 12 CFR 204.130 - Eligibility for NOW accounts.

    Science.gov (United States)

    2010-01-01

    ... maintain NOW accounts directly. The Board believes that these accounts are similar in nature to trust... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Eligibility for NOW accounts. 204.130 Section... NOW accounts. (a) Summary. In response to many requests for rulings, the Board has determined...

  14. 18 CFR 367.2040 - Account 204, Preferred stock issued.

    Science.gov (United States)

    2010-04-01

    ... stock issued. 367.2040 Section 367.2040 Conservation of Power and Water Resources FEDERAL ENERGY... GAS ACT Balance Sheet Chart of Accounts Proprietary Capital § 367.2040 Account 204, Preferred stock issued. This account must include the par or stated value of all preferred stock issued and outstanding....

  15. 41 CFR 50-204.75 - Transportation safety.

    Science.gov (United States)

    2010-07-01

    ... Transportation Safety § 50-204.75 Transportation safety. Any requirements of the U.S. Department of Transportation under 49 CFR Parts 171-179 and Parts 390-397 and 14 CFR Part 103 shall be applied to... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Transportation safety....

  16. 41 CFR 101-6.204-3 - Special benefits.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Special benefits. 101-6...-Nondiscrimination in Programs Receiving Federal Financial Assistance § 101-6.204-3 Special benefits. An individual shall not be deemed subjected to discrimination by reason of his exclusion from benefits limited...

  17. 40 CFR 6.204 - Categorical exclusions and extraordinary circumstances.

    Science.gov (United States)

    2010-07-01

    ... EFFECTS ABROAD OF EPA ACTIONS EPA's NEPA Environmental Review Procedures § 6.204 Categorical exclusions... occurs; educational and training programs; literature searches and studies; computer studies and... Director or other appropriate official must certify in writing that the laboratory follows good...

  18. 31 CFR 536.204 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 536... Prohibitions § 536.204 Evasions; attempts; conspiracies. Any transaction for the purpose of, or which has the... this part is hereby prohibited. Any conspiracy formed for the purpose of engaging in a...

  19. 31 CFR 597.204 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 597... REGULATIONS Prohibitions § 597.204 Evasions; attempts; conspiracies. Any transaction for the purpose of, or... set forth in this part is hereby prohibited. Any conspiracy formed for the purpose of engaging in...

  20. 31 CFR 541.204 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 541... § 541.204 Evasions; attempts; conspiracies. (a) Except as otherwise authorized, and notwithstanding any... or any license or permit granted prior to the effective date, any conspiracy formed to violate...

  1. 31 CFR 598.204 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 598... REGULATIONS Prohibitions § 598.204 Evasions; attempts; conspiracies. Except to the extent provided in... the effect of evading or avoiding, and any endeavor, attempt, or conspiracy to violate any of...

  2. 31 CFR 588.204 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 588... Prohibitions § 588.204 Evasions; attempts; conspiracies. (a) Except as otherwise authorized, and... entered into or any license or permit granted prior to the effective date, any conspiracy formed for...

  3. 31 CFR 587.204 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 587... MONTENEGRO) MILOSEVIC SANCTIONS REGULATIONS Prohibitions § 587.204 Evasions; attempts; conspiracies. (a... date, any conspiracy formed for the purpose of engaging in a transaction prohibited by this part...

  4. 15 CFR 270.204 - Provision of additional resources and services needed by a Team.

    Science.gov (United States)

    2010-01-01

    ... services needed by a Team. 270.204 Section 270.204 Commerce and Foreign Trade Regulations Relating to... CONSTRUCTION SAFETY TEAMS NATIONAL CONSTRUCTION SAFETY TEAMS Investigations § 270.204 Provision of additional resources and services needed by a Team. The Director will determine the appropriate resources that a...

  5. 31 CFR 575.204 - Prohibited importation of goods or services from Iraq.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Prohibited importation of goods or services from Iraq. 575.204 Section 575.204 Money and Finance: Treasury Regulations Relating to Money and... REGULATIONS Prohibitions § 575.204 Prohibited importation of goods or services from Iraq. Except as...

  6. 12 CFR 741.204 - Maximum public unit and nonmember accounts, and low-income designation.

    Science.gov (United States)

    2010-01-01

    ... low-income designation. 741.204 Section 741.204 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... Unions § 741.204 Maximum public unit and nonmember accounts, and low-income designation. Any credit union...) Obtain a low-income designation in order to accept nonmember accounts, other than from public units...

  7. 41 CFR 50-204.33 - Disclosure to former employee of individual employee's record.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Disclosure to former employee of individual employee's record. 50-204.33 Section 50-204.33 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 204-SAFETY AND HEALTH STANDARDS FOR FEDERAL...

  8. 18 CFR 3b.204 - Safeguarding information in manual and computer-based record systems.

    Science.gov (United States)

    2010-04-01

    ... information in manual and computer-based record systems. 3b.204 Section 3b.204 Conservation of Power and Water... Collection of Records § 3b.204 Safeguarding information in manual and computer-based record systems. (a) The administrative and physical controls to protect the information in the manual and computer-based record...

  9. 40 CFR 88.204-94 - Sales requirements for the California Pilot Test Program.

    Science.gov (United States)

    2010-07-01

    ... Pilot Test Program. 88.204-94 Section 88.204-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES California Pilot Test Program § 88.204-94 Sales requirements for the California Pilot Test Program. (a) The total annual required minimum...

  10. 8 CFR 204.306 - Classification as an immediate relative based on a Convention adoption.

    Science.gov (United States)

    2010-01-01

    ....306 Classification as an immediate relative based on a Convention adoption. (a) Unless 8 CFR 204.309... process: (1) First, the U.S. citizen must file a Form I-800A under 8 CFR 204.310; (2) Then, once USCIS has... adoptee, the U.S. citizen must file a Form I-800 under 8 CFR 204.313....

  11. 48 CFR 52.204-5 - Women-Owned Business (Other Than Small Business).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Women-Owned Business (Other Than Small Business). 52.204-5 Section 52.204-5 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.204-5 Women-Owned Business (Other Than Small Business). As prescribed in...

  12. 30 CFR 285.204 - What areas are available for leasing consideration?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What areas are available for leasing consideration? 285.204 Section 285.204 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... OCS Renewable Energy Leases General Lease Information § 285.204 What areas are available for...

  13. 41 CFR 50-204.6 - Medical services and first aid.

    Science.gov (United States)

    2010-07-01

    ... first aid. 50-204.6 Section 50-204.6 Public Contracts and Property Management Other Provisions Relating... SUPPLY CONTRACTS General Safety and Health Standards § 50-204.6 Medical services and first aid. (a) The... trained to render first aid. First aid supplies approved by the consulting physician shall be...

  14. 44 CFR 204.23 - Processing a request for a fire management assistance declaration.

    Science.gov (United States)

    2010-10-01

    ... ASSISTANCE GRANT PROGRAM Declaration Process § 204.23 Processing a request for a fire management assistance... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Processing a request for a fire management assistance declaration. 204.23 Section 204.23 Emergency Management and...

  15. 12 CFR 747.204 - Notice of intention to terminate insured status.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Notice of intention to terminate insured status. 747.204 Section 747.204 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING... Status § 747.204 Notice of intention to terminate insured status. Unless correction of the...

  16. 12 CFR 204.122 - Secondary market activities of international banking facilities.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Secondary market activities of international banking facilities. 204.122 Section 204.122 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF...) Interpretations § 204.122 Secondary market activities of international banking facilities. (a) Questions have...

  17. 44 CFR 204.25 - FEMA-State agreement for fire management assistance grant program.

    Science.gov (United States)

    2010-10-01

    ... GRANT PROGRAM Declaration Process § 204.25 FEMA-State agreement for fire management assistance grant... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false FEMA-State agreement for fire management assistance grant program. 204.25 Section 204.25 Emergency Management and Assistance...

  18. 44 CFR 204.24 - Determination on request for a fire management assistance declaration.

    Science.gov (United States)

    2010-10-01

    ... ASSISTANCE GRANT PROGRAM Declaration Process § 204.24 Determination on request for a fire management... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Determination on request for a fire management assistance declaration. 204.24 Section 204.24 Emergency Management and...

  19. 44 CFR 204.26 - Appeal of fire management assistance declaration denial.

    Science.gov (United States)

    2010-10-01

    ... PROGRAM Declaration Process § 204.26 Appeal of fire management assistance declaration denial. (a... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Appeal of fire management assistance declaration denial. 204.26 Section 204.26 Emergency Management and Assistance FEDERAL...

  20. 26 CFR 601.204 - Changes in accounting periods and in methods of accounting.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 20 2010-04-01 2010-04-01 false Changes in accounting periods and in methods of accounting. 601.204 Section 601.204 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INTERNAL REVENUE PRACTICE STATEMENT OF PROCEDURAL RULES Rulings and Other Specific Matters § 601.204 Changes in accounting...

  1. 48 CFR 53.204-1 - Safeguarding classified information within industry (DD Form 254, DD Form 441).

    Science.gov (United States)

    2010-10-01

    ... information within industry (DD Form 254, DD Form 441). 53.204-1 Section 53.204-1 Federal Acquisition....204-1 Safeguarding classified information within industry (DD Form 254, DD Form 441). The following... specified in subpart 4.4 and the clause at 52.204-2: (a) DD Form 254 (Department of Defense (DOD)),...

  2. Extraction of Indium with Mixture of P204 and Cyanex 923%P204-Cyanex 923混合溶剂萃取铟

    Institute of Scientific and Technical Information of China (English)

    张瑾; 刘大星; 王春; 戴猷元

    2000-01-01

    研究了P204、P507、Cyanex 923及P204单一体系与3种中性有机磷萃取剂(Cyanex 923、TRPO 、TBP)组成的混合体系对In(Ⅲ)、Fe(Ⅲ)的萃取和反萃性能. 发现在P204中加入Cyanex 92 3使In(Ⅲ)的萃取率略有下降,反萃率提高. 红外光谱分析证明P204与Cyanex 923存在缔合作用,抑制P204与In(Ⅲ)和Fe(Ⅲ)的离子交换反应,可以提高过程的反萃率.

  3. 29 CFR 778.204 - “Clock pattern” premium pay.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false âClock patternâ premium pay. 778.204 Section 778.204 Labor... Excluded From the âRegular Rateâ Extra Compensation Paid for Overtime § 778.204 “Clock pattern” premium pay. (a) Overtime premiums under section 7(e)(7). Where a collective bargaining agreement or...

  4. 19 CFR 351.204 - Time periods and persons examined; voluntary respondents; exclusions.

    Science.gov (United States)

    2010-04-01

    ... § 351.204 Time periods and persons examined; voluntary respondents; exclusions. (a) Introduction... fiscal quarters (or, in an investigation involving merchandise imported from a nonmarket economy...

  5. 30 CFR 210.204 - How do I submit facility data?

    Science.gov (United States)

    2010-07-01

    ... you submit facility data by paper copy, send it to the applicable address given in § 210.202(c)(2). ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I submit facility data? 210.204 Section... MANAGEMENT FORMS AND REPORTS Production and Royalty Reports-Solid Minerals § 210.204 How do I submit...

  6. 17 CFR 275.204A-1 - Investment adviser codes of ethics.

    Science.gov (United States)

    2010-04-01

    ... ethics. 275.204A-1 Section 275.204A-1 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... codes of ethics. (a) Adoption of code of ethics. If you are an investment adviser registered or required... enforce a written code of ethics that, at a minimum, includes: (1) A standard (or standards) of...

  7. 27 CFR 26.204a - Verification of eligible wines and eligible flavors.

    Science.gov (United States)

    2010-04-01

    ... wines and eligible flavors. 26.204a Section 26.204a Alcohol, Tobacco Products and Firearms ALCOHOL AND... Verification of eligible wines and eligible flavors. (a) Any person who, after December 1, 1990, brings into... eligible wines shall, before the first tax determination at that rate, request and receive a statement...

  8. 27 CFR 19.204 - Alternation of distilled spirits plant and taxpaid wine bottling house premises.

    Science.gov (United States)

    2010-04-01

    ... spirits plant and taxpaid wine bottling house premises. 19.204 Section 19.204 Alcohol, Tobacco Products... distilled spirits plant and taxpaid wine bottling house premises. (a) General. A proprietor of a distilled spirits plant operating a contiguous taxpaid wine bottling house desiring to alternate the use of...

  9. 17 CFR 204.55 - Change in notification to Financial Management Service.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Change in notification to Financial Management Service. 204.55 Section 204.55 Commodity and Securities Exchanges SECURITIES AND... Financial Management Service. After the Commission sends FMS notification of an individual's liability for...

  10. 8 CFR 204.308 - Where to file Form I-800A or Form I-800.

    Science.gov (United States)

    2010-01-01

    ... provisionally approved under 8 CFR 204.313(g) and the petitioner has either adopted or obtained custody of the child for purposes of emigration and adoption, the Department of State officer with jurisdiction to... eligible both under 8 CFR 204.309(b)(4) for approval of a Form I-800 and under 8 CFR part 245...

  11. 30 CFR 204.205 - How do I obtain accounting and auditing relief?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I obtain accounting and auditing relief? 204.205 Section 204.205 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and Auditing Relief §...

  12. 30 CFR 204.201 - Who may obtain accounting and auditing relief?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who may obtain accounting and auditing relief? 204.201 Section 204.201 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and Auditing Relief §...

  13. 48 CFR 1652.204-72 - Filing health benefit claims/court review of disputed claims.

    Science.gov (United States)

    2010-10-01

    ... inserted in all FEHB Program contracts. Filing Health Benefit Claims/Court Review of Disputed Claims (MAR... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Filing health benefit claims/court review of disputed claims. 1652.204-72 Section 1652.204-72 Federal Acquisition...

  14. 40 CFR 211.204-1 - Information content of -primary label.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Information content of -primary label. 211.204-1 Section 211.204-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... content of -primary label. The information to appear on the -primary label must be according -to §...

  15. 42 CFR 411.204 - Medicare benefits secondary to LGHP benefits.

    Science.gov (United States)

    2010-10-01

    ....204 Section 411.204 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM EXCLUSIONS FROM MEDICARE AND LIMITATIONS ON MEDICARE PAYMENT Special... services furnished during any month in which the individual— (1) Is entitled to Medicare Part A...

  16. 48 CFR 3052.204-70 - Security requirements for unclassified information technology resources.

    Science.gov (United States)

    2010-10-01

    ... for unclassified information technology resources. As prescribed in (HSAR) 48 CFR 3004.470-3, insert a clause substantially the same as follows: Security Requirements for Unclassified Information Technology... unclassified information technology resources. 3052.204-70 Section 3052.204-70 Federal Acquisition...

  17. 5 CFR 890.204 - Withdrawal of approval of health benefits plans or carriers.

    Science.gov (United States)

    2010-01-01

    ... CFR subpart 1609.70 are not met. Such action carries with it the right to a hearing as provided in... plans or carriers. 890.204 Section 890.204 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT... documentary evidence, including rebuttal evidence, in opposition to the proposed action. (i) A...

  18. 23 CFR 500.204 - TMS components for highway traffic data.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false TMS components for highway traffic data. 500.204 Section... INFRASTRUCTURE MANAGEMENT MANAGEMENT AND MONITORING SYSTEMS Traffic Monitoring System § 500.204 TMS components for highway traffic data. (a) General. Each State's TMS, including those using alternative...

  19. Separation of nickel, cobalt and copper by solvent extraction with P204

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Nickel, cobalt and copper were separated by solvent extraction with P204. The experimental results show that [Co(NH3)6]3+ is an inert complex in extraction kinetics, therefore cobalt can be separated from nickel and copper by non-equilibrium solvent extraction. Under the conditions of temperature 25℃, contact time of two phases 10 min, phase ratio 1:1, aqueous pH 10.10 and concentration of P204 20 %, [ Co(NH3 )6 3+ is hardly extracted by P204, while the percentage extractions of nickel and copper are 79.3 % and 93.9 % respectively. Nickel and copper are separated by equi librium solvent extraction with P204. Under the conditions of temperature 25 ℃, contact time of two phases 1 min, phase ratio 1:1, equilibrium pH 4.01 and concentration of P204 20%, the separation factor of copper and nickel is 216.

  20. Strain gage sting balance 204-6. Calibration report

    Science.gov (United States)

    Blaettler, Heinz

    1986-12-01

    The strain gage sting balance 204-6 was developed for aerodynamic measurements on rocket models in the transonic and supersonic wind tunnel. Data are: X = +/- 50 (N); Y = +/- 150 (N); Z = +/- 400 (N); Mx = +/- 1.5 (Nm); My = +/- 20 (Nm); and Mz = +/- 10 (Nm). Compared to the existing balances of same size the ratio Y/Z is changed from 1:8 to 1:3.75. This change of specifications was introduced with regard to measurements to be taken with a sting providing automatic roll positioning around the X-axis. The resistance module was separately constructed and prestressed by a factor of 0.5, and connected to the model and sting part of the balance by electron-beam welding.

  1. 20 CFR 204.7 - Employment relation-service to a local lodge or division of a railway labor organization.

    Science.gov (United States)

    2010-04-01

    ... or division of a railway labor organization. 204.7 Section 204.7 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT EMPLOYMENT RELATION § 204.7 Employment relation—service to a local lodge or division of a railway labor organization. Service by an individual...

  2. 8 CFR 204.7 - Preservation of benefits contained in savings clause of Immigration and Nationality Act...

    Science.gov (United States)

    2010-01-01

    ... savings clause of Immigration and Nationality Act Amendments of 1976. 204.7 Section 204.7 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.7 Preservation of benefits contained in savings clause of Immigration and Nationality...

  3. 24 CFR 960.204 - Denial of admission for criminal activity or drug abuse by household members.

    Science.gov (United States)

    2010-04-01

    ... activity or drug abuse by household members. 960.204 Section 960.204 Housing and Urban Development... HOUSING Admission § 960.204 Denial of admission for criminal activity or drug abuse by household members. (a) Required denial of admission—(1) Persons evicted for drug-related criminal activity. The...

  4. 10 CFR 431.204 - Uniform test method for the measurement of energy consumption of illuminated exit signs.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Uniform test method for the measurement of energy consumption of illuminated exit signs. 431.204 Section 431.204 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION... Procedures § 431.204 Uniform test method for the measurement of energy consumption of illuminated exit...

  5. 30 CFR 204.207 - Who will approve, deny, or modify my request for accounting and auditing relief?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who will approve, deny, or modify my request for accounting and auditing relief? 204.207 Section 204.207 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ALTERNATIVES FOR MARGINAL PROPERTIES Accounting and Auditing Relief § 204.207 Who...

  6. 30 CFR 204.5 - What statutory requirements must I meet to obtain royalty prepayment or accounting and auditing...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What statutory requirements must I meet to obtain royalty prepayment or accounting and auditing relief? 204.5 Section 204.5 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT ALTERNATIVES FOR MARGINAL PROPERTIES General Provisions § 204.5...

  7. 48 CFR 27.204-1 - Use of patented technology under the North American Free Trade Agreement.

    Science.gov (United States)

    2010-10-01

    ... under the North American Free Trade Agreement. 27.204-1 Section 27.204-1 Federal Acquisition Regulations... Patents and Copyrights 27.204-1 Use of patented technology under the North American Free Trade Agreement... the patent holder is from a country that is a party to the North American Free Trade Agreement...

  8. 5 CFR 894.204 - May I be enrolled in more than one dental or vision plan at a time?

    Science.gov (United States)

    2010-01-01

    ... or vision plan at a time? 894.204 Section 894.204 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES DENTAL AND VISION INSURANCE PROGRAM Coverage and Types of Enrollment § 894.204 May I be enrolled in more than one dental or...

  9. 8 CFR 204.11 - Special immigrant status for certain aliens declared dependent on a juvenile court (special...

    Science.gov (United States)

    2010-01-01

    ... declared dependent on a juvenile court (special immigrant juvenile). 204.11 Section 204.11 Aliens and... Petitions § 204.11 Special immigrant status for certain aliens declared dependent on a juvenile court (special immigrant juvenile). (a) Definitions. Eligible for long-term foster care means that...

  10. miR-204-5p suppresses cell proliferation by inhibiting IGFBP5 in papillary thyroid carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Lianyong; Wang, Jingnan; Li, Xiangqi; Ma, Junhua; Shi, Chao; Zhu, Hongling; Xi, Qian; Zhang, Jichen; Zhao, Xuemei; Gu, Mingjun, E-mail: mjgugonglihos@yeah.net

    2015-02-20

    microRNAs (miRNAs) are frequently dysregulated in human malignancies. It was recently shown that miR-204-5p is downregulated in papillary thyroid carcinoma (PTC); however, the functional significance of this observation is not known. This study investigated the role of miR-204-5p in PTC. Overexpressing miR-204-5p suppressed PTC cell proliferation and induced cell cycle arrest and apoptosis. The results of a luciferase reporter assay showed that miR-204-5p can directly bind to the 3′ untranslated region (UTR) of insulin-like growth factor-binding protein 5 (IGFBP5) mRNA, and IGFBP5 overexpression partially reversed the growth-inhibitory effects of miR-204-5p. These results indicate that miR-204-5p acts as a tumor suppressor in PTC by regulating IGFBP5 expression and that miR-204-5p can potentially serve as an antitumorigenic agent in the treatment of PTC. - Highlights: • miR-204-5p expression is downregulated in PTC tissues and cell lines. • miR-204-5p suppresses proliferation and promotes apoptosis in PTC cells. • miR-204-5p suppresses IGFBP5 expression by direct binding to the 3′-UTR. • IGFBP5 overexpression reverses the effects of miR-204-5p.

  11. Yeast Interacting Proteins Database: YPL204W, YOL149W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YPL204W HRR25 Protein kinase involved in regulating diverse events including vesicu...tion Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and c

  12. Yeast Interacting Proteins Database: YPL204W, YHR185C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YPL204W HRR25 Protein kinase involved in regulating diverse events including vesicu...e HRR25 Bait description Protein kinase involved in regulating diverse events including vesicular traffickin

  13. Yeast Interacting Proteins Database: YPL204W, YER095W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YPL204W HRR25 Protein kinase involved in regulating diverse events including vesicu... gene name HRR25 Bait description Protein kinase involved in regulating diverse events including vesicular t

  14. Electron Scattering from MERCURY-198 and Mercury -204.

    Science.gov (United States)

    Laksanaboonsong, Jarungsaeng

    This experiment is the first electron scattering study on mercury isotopes. Electron scattering from ^{198}Hg and ^{204 }Hg has been performed at the NIKHEF-K Medium Energy Accelerator. Measured cross sections cover an effective momentum transfer range from 0.4 to 2.9 fm^ {-1}. Elastic cross sections were determined for scattering from both isotopes. Cross section for inelastic excitations in ^{198}Hg below 3 MeV were also determined. Measured cross sections were fit using DWBA phase shift codes to determine coefficients for Fourier-Bessel expansions of ground state and transition charge densities. Differences between the ground state charge densities of the two isotopes reveal the effect of the polarization of the proton core in response to the addition of neutrons. Spin and parity of several excited states of ^{198}Hg were determined. Extracted transition densities of these states show their predominantly collective nature. Charge densities for members of the ground state rotational band were compared with axially symmetric Hartree-Fock and geometrical model predictions.

  15. miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer

    Science.gov (United States)

    Sacconi, A; Biagioni, F; Canu, V; Mori, F; Di Benedetto, A; Lorenzon, L; Ercolani, C; Di Agostino, S; Cambria, A M; Germoni, S; Grasso, G; Blandino, R; Panebianco, V; Ziparo, V; Federici, O; Muti, P; Strano, S; Carboni, F; Mottolese, M; Diodoro, M; Pescarmona, E; Garofalo, A; Blandino, G

    2012-01-01

    Micro RNAs (miRs) are small non-coding RNAs aberrantly expressed in human tumors. Here, we aim to identify miRs whose deregulated expression leads to the activation of oncogenic pathways in human gastric cancers (GCs). Thirty nine out of 123 tumoral and matched uninvolved peritumoral gastric specimens from three independent European subsets of patients were analyzed for the expression of 851 human miRs using Agilent Platform. The remaining 84 samples were used to validate miRs differentially expressed between tumoral and matched peritumoral specimens by qPCR. miR-204 falls into a group of eight miRs differentially expressed between tumoral and peritumoral samples. Downregulation of miR-204 has prognostic value and correlates with increased staining of Bcl-2 protein in tumoral specimens. Ectopic expression of miR-204 inhibited colony forming ability, migration and tumor engraftment of GC cells. miR-204 targeted Bcl-2 messenger RNA and increased responsiveness of GC cells to 5-fluorouracil and oxaliplatin treatment. Ectopic expression of Bcl-2 protein counteracted miR-204 pro-apoptotic activity in response to 5-fluorouracil. Altogether, these findings suggest that modulation of aberrant expression of miR-204, which in turn releases oncogenic Bcl-2 protein activity might hold promise for preventive and therapeutic strategies of GC. PMID:23152059

  16. Lung collagens perpetuate pulmonary fibrosis via CD204 and M2 macrophage activation.

    Directory of Open Access Journals (Sweden)

    Mirjam Stahl

    Full Text Available Idiopathic pulmonary fibrosis is characterized by abundant collagen production and accumulation of alternatively activated macrophages (M2 in the lower respiratory tract. Mechanisms as to how alveolar macrophages are activated by collagen breakdown products are unknown. Alveolar macrophages were obtained by bronchoalveolar lavage from 30 patients with idiopathic pulmonary fibrosis (IPF and 37 healthy donors (HD. Alveolar macrophages were cultured in the presence of collagen type I, III, IV and V monomers w/wo a neutralizing antibody against scavenger receptor I class A (CD204. Culture supernatants were assayed for the M2 markers CCL18, CCL2, and interleukin-1 receptor antagonist (IL-1ra by ELISA. Furthermore, expression of phospho-Akt was measured using ELISA and expression of CD204 by RT-PCR and flow cytometry. Stimulation with collagen type I and III monomers significantly up-regulated CCL18, IL-1ra production of alveolar macrophages. Furthermore, expression of CCL2 and CD204 were up-regulated by collagen type I exposure. In addition, collagen type I stimulation increased pospho-Akt expression. Collagen type I effects were abrogated by neutralizing antiCD204 and a non-selective Phosphatidylinositide 3-kinase inhibitor (LY294002. Spontaneous CD204 expression of alveolar macrophages was significantly increased in patients with IPF. In conclusion, our findings demonstrate that monomeric collagen type I via CD204 induces phospho-Akt expression shifting alveolar macrophages to the profibrotic M2 type. Innate immune responses induced by collagen monomers might perpetuate pulmonary fibrosis.

  17. MiR-204 is responsible for inherited retinal dystrophy associated with ocular coloboma.

    Science.gov (United States)

    Conte, Ivan; Hadfield, Kristen D; Barbato, Sara; Carrella, Sabrina; Pizzo, Mariateresa; Bhat, Rajeshwari S; Carissimo, Annamaria; Karali, Marianthi; Porter, Louise F; Urquhart, Jill; Hateley, Sofie; O'Sullivan, James; Manson, Forbes D C; Neuhauss, Stephan C F; Banfi, Sandro; Black, Graeme C M

    2015-06-23

    Ocular developmental disorders, including the group classified as microphthalmia, anophthalmia, and coloboma (MAC) and inherited retinal dystrophies, collectively represent leading causes of hereditary blindness. Characterized by extreme genetic and clinical heterogeneity, the separate groups share many common genetic causes, in particular relating to pathways controlling retinal and retinal pigment epithelial maintenance. To understand these shared pathways and delineate the overlap between these groups, we investigated the genetic cause of an autosomal dominantly inherited condition of retinal dystrophy and bilateral coloboma, present in varying degrees in a large, five-generation family. By linkage analysis and exome sequencing, we identified a previously undescribed heterozygous mutation, n.37 C > T, in the seed region of microRNA-204 (miR-204), which segregates with the disease in all affected individuals. We demonstrated that this mutation determines significant alterations of miR-204 targeting capabilities via in vitro assays, including transcriptome analysis. In vivo injection, in medaka fish (Oryzias latipes), of the mutated miR-204 caused a phenotype consistent with that observed in the family, including photoreceptor alterations with reduced numbers of both cones and rods as a result of increased apoptosis, thereby confirming the pathogenic effect of the n.37 C > T mutation. Finally, knockdown assays in medaka fish demonstrated that miR-204 is necessary for normal photoreceptor function. Overall, these data highlight the importance of miR-204 in the regulation of ocular development and maintenance and provide the first evidence, to our knowledge, of its contribution to eye disease, likely through a gain-of-function mechanism. PMID:26056285

  18. 14 CFR 204.6 - Certificated and commuter air carriers proposing a change in operations, ownership, or management...

    Science.gov (United States)

    2010-01-01

    ... proposing a change in operations, ownership, or management which is not substantial. 204.6 Section 204.6... carriers proposing a change in operations, ownership, or management which is not substantial. Carriers proposing to make a change which would not substantially affect their operations, management, or...

  19. 12 CFR 204.123 - Sale of Federal funds by investment companies or trusts in which the entire beneficial interest...

    Science.gov (United States)

    2010-01-01

    ... CFR 204.2(a)(1)(vii)(A)(1)). These exemptions from the definition of deposit are known collectively as... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Sale of Federal funds by investment companies... SYSTEM RESERVE REQUIREMENTS OF DEPOSITORY INSTITUTIONS (REGULATION D) Interpretations § 204.123 Sale...

  20. 24 CFR 1000.204 - How does an Indian tribe designate itself as recipient of the grant?

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false How does an Indian tribe designate itself as recipient of the grant? 1000.204 Section 1000.204 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND...

  1. 30 CFR 204.215 - Are the information collection requirements in this subpart approved by the Office of Management...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Are the information collection requirements in this subpart approved by the Office of Management and Budget (OMB)? 204.215 Section 204.215 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT...

  2. Draft Genome Sequences of 15 Isolates of Listeria monocytogenes Serotype 1/2a, Subgroup ST204.

    Science.gov (United States)

    Allnutt, Theodore R; Bradbury, Mark I; Fanning, Séamus; Chandry, P Scott; Fox, Edward M

    2016-01-01

    Listeria monocytogenes sequence type 204 (ST204) strains have been isolated from a range of food, environmental, and clinical sources in Australia. This study describes the draft genome sequences of 15 isolates collected from meat and dairy associated sources. PMID:27609916

  3. Model Validation at the 204 MW New Mexico Wind Energy Center: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Muljadi, E.; Butterfield, C. P.; Ellis, A.; Mechenbier, J.; Hochheimer, J.; Young, R.; Miller, N.; Delmerico, R.; Zavadil, R.; Smith, J. C.

    2006-06-01

    In this paper, we describe methods to derive and validate equivalent models for a large wind farm. FPL Energy's 204-MW New Mexico Wind Energy Center, which is interconnected to the Public Service Company of New Mexico (PNM) transmission system, was used as a case study. The methods described are applicable to any large wind power plant.

  4. 7 CFR 1744.204 - Rural development investments that do not meet the ratio requirements.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Rural development investments that do not meet the... GUARANTEED AND INSURED TELEPHONE LOANS Borrower Investments § 1744.204 Rural development investments that do... consider, on a case-by-case basis, requests for approval of rural development investments not...

  5. 34 CFR 403.204 - What are the State's responsibilities for program evaluation and improvement?

    Science.gov (United States)

    2010-07-01

    ... APPLIED TECHNOLOGY EDUCATION PROGRAM What Are the Administrative Responsibilities of a State Under the State Vocational and Applied Technology Education Program? § 403.204 What are the State's... 34 Education 3 2010-07-01 2010-07-01 false What are the State's responsibilities for...

  6. 42 CFR 412.204 - Payment to hospitals located in Puerto Rico.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Payment to hospitals located in Puerto Rico. 412... Payment System for Inpatient Operating Costs for Hospitals Located in Puerto Rico § 412.204 Payment to hospitals located in Puerto Rico. (a) FY 1988 through FY 1997. For discharges occurring on or after...

  7. 31 CFR 515.803 - Customs procedures; merchandise specified in § 515.204.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Customs procedures; merchandise... CONTROL REGULATIONS Procedures § 515.803 Customs procedures; merchandise specified in § 515.204. (a) With... thereto) whether or not such merchandise has been imported into the United States, collectors of...

  8. 31 CFR 500.803 - Customs procedures; merchandise specified in § 500.204.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Customs procedures; merchandise... CONTROL REGULATIONS Procedures § 500.803 Customs procedures; merchandise specified in § 500.204. (a) With... United States, directors of customs shall not accept or allow any: (1) Entry for consumption...

  9. 8 CFR 204.313 - Filing and adjudication of a Form I-800.

    Science.gov (United States)

    2010-01-01

    ... service provider's plan for post-placement duties, as specified in 22 CFR 96.50; and (5) If the child may... has given the notice contemplated by article 5(c) of the Convention, shall constitute prima facie... jurisdiction under 8 CFR 204.308(b) to adjudicate the Form I-800, together with the evidence specified in...

  10. 5 CFR 842.204 - Immediate voluntary retirement-basic age and service requirements.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Immediate voluntary retirement-basic age... ANNUITY Eligibility § 842.204 Immediate voluntary retirement—basic age and service requirements. (a) An... paragraph (d) of this section, after attaining the minimum retirement age and completing 10 years of...

  11. 13 CFR 106.204 - Who has the authority to approve and sign a Cosponsorship Agreement?

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Who has the authority to approve... Cosponsored Activities § 106.204 Who has the authority to approve and sign a Cosponsorship Agreement? The... administrator, after consultation with the General Counsel (or designee), has the authority to approve...

  12. 44 CFR 204.22 - Submitting a request for a fire management assistance declaration.

    Science.gov (United States)

    2010-10-01

    ... ASSISTANCE GRANT PROGRAM Declaration Process § 204.22 Submitting a request for a fire management assistance.... To ensure that we can process a State's request for a fire management assistance declaration as... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Submitting a request for...

  13. 13 CFR 126.204 - May a qualified HUBZone SBC have affiliates?

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false May a qualified HUBZone SBC have... PROGRAM Requirements to be a Qualified HUBZone SBC § 126.204 May a qualified HUBZone SBC have affiliates? A concern may have affiliates provided that the aggregate size of the concern and all of...

  14. miR-204对癫痫神经元中BDNF/TrkB信号通路的影响%The Study of miR-204 Regulates BDNF/TrkB Expression in Epileptic Neurons

    Institute of Scientific and Technical Information of China (English)

    常伟; 潘立平; 吴秋静; 宋毅军

    2014-01-01

    Objective To study the effect of miR-204 on BDNF/TrkB signaling and pathogenesis on the neuron model of epilepsy. Methods Primary hippocampal neurons were cultured in vitro for 7 days, and were divided into control group, control+BDNF group, epilepsy group, epilepsy+BDNF group , control+miR204 group, epilepsy+miR204 group and ep-ilepsy+miR204+BDNF group. The epilepsy model of hippocampal neurons was established by being exposed to Mg2+free me-dia for 3 hours. The miR-204 lentivirus vector was constructed. The effect of miR-204 on BDNF/TrkB expression was detect-ed by immunohistochemistry, patch clamp and Western blot technique. Results Compared with the control group, the TrkB phosphorylation level was higher in control+BDNF group. The TrkB phosphorylation level was lower in epilepsy+BDNF group than that of control+BDNF group, but it was higher than that of epilepsy group. The TrkB phosphorylation level was higher in epilepsy+miR204+BDNF group than that of epilepsy+BDNF group and epilepsy+ miR204 group. Conclusion BDNF and miR-204 can improve the inhibitory condition of BDNF/TrkB signaling and may play an important role in alleviat-ing epilepsy disease.%目的:研究海马神经元癫痫模型中转染miR-204后对脑源性神经营养因子(BDNF)与TrkB通路调控作用的影响。方法取原代培养7 d后的细胞,分为正常组、正常+BDNF组、癫痫组、癫痫+BDNF组、正常转染miR-204组、癫痫转染miR-204组、癫痫转染miR-204+BDNF组。癫痫组用无镁液处理3 h制作癫痫模型。制备成功miR-204慢病毒表达载体。采用免疫荧光、膜片钳及免疫印迹技术鉴定及观察miR-204对BDNF/TrkB通路表达的影响。结果 TrkB蛋白的磷酸化水平:正常+BDNF组高于正常组;癫痫+BDNF组低于正常+BDNF组,高于癫痫组;癫痫+miR-204+BDNF组高于癫痫+BDNF组和癫痫+miR-204组。结论BDNF及miR-204可以改善BDNF/TrkB受抑制的状态,从而在癫痫疾病的缓解中可能发挥重要作用。

  15. MiR-204-5p suppresses cell proliferation by inhibiting IGFBP5 in papillary thyroid carcinoma.

    Science.gov (United States)

    Liu, Lianyong; Wang, Jingnan; Li, Xiangqi; Ma, Junhua; Shi, Chao; Zhu, Hongling; Xi, Qian; Zhang, Jichen; Zhao, Xuemei; Gu, Mingjun

    2015-02-20

    microRNAs (miRNAs) are frequently dysregulated in human malignancies. It was recently shown that miR-204-5p is downregulated in papillary thyroid carcinoma (PTC); however, the functional significance of this observation is not known. This study investigated the role of miR-204-5p in PTC. Overexpressing miR-204-5p suppressed PTC cell proliferation and induced cell cycle arrest and apoptosis. The results of a luciferase reporter assay showed that miR-204-5p can directly bind to the 3' untranslated region (UTR) of insulin-like growth factor-binding protein 5 (IGFBP5) mRNA, and IGFBP5 overexpression partially reversed the growth-inhibitory effects of miR-204-5p. These results indicate that miR-204-5p acts as a tumor suppressor in PTC by regulating IGFBP5 expression and that miR-204-5p can potentially serve as an antitumorigenic agent in the treatment of PTC.

  16. miR-204-5p regulates cell proliferation and metastasis through inhibiting CXCR4 expression in OSCC.

    Science.gov (United States)

    Wang, Xinjuan; Li, Fujun; Zhou, Xiaoli

    2016-08-01

    MicroRNAs (miRNAs) are important small molecules in cancer including oral squamous cell carcinoma (OSCC) which regulate gene expression at post-transcriptional levels. MiR-204-5p acts as a tumor suppressor in some of cancers, but the role of it in OSCC is not known. The aim of this study is to investigate the expression and functional roles of miR-204-5p in OSCC. The results showed that the expression of miR-204-5p was lower in cancer tissues or cells. Next, cell proliferation, cell cycle, migration and invasion were detected. It was found that miR-204-5p could enhance OSCC cell proliferation and metastasis. MiR-204-5p was predicted as a regulatory miRNA of CXCR4 in OSCC, and the data analysis indicated that there was a negatively relationship between miR-204-5p and CXCR4 expression in OSCC tissues from the patients. In a conclusion, our findings suggested that miR-204-5p may function as an inhibitory RNA molecule in OSCC by targeting CXCR4. PMID:27470356

  17. Dual targeting of ANGPT1 and TGFBR2 genes by miR-204 controls angiogenesis in breast cancer

    Science.gov (United States)

    Flores-Pérez, Ali; Marchat, Laurence A.; Rodríguez-Cuevas, Sergio; Bautista-Piña, Verónica; Hidalgo-Miranda, Alfredo; Ocampo, Elena Aréchaga; Martínez, Mónica Sierra; Palma-Flores, Carlos; Fonseca-Sánchez, Miguel A.; Astudillo-de la Vega, Horacio; Ruíz-García, Erika; González-Barrios, Juan Antonio; Pérez-Plasencia, Carlos; Streber, María L.; López-Camarillo, César

    2016-01-01

    Deregulated expression of microRNAs has been associated with angiogenesis. Studying the miRNome of locally advanced breast tumors we unsuspectedly found a dramatically repression of miR-204, a small non-coding RNA with no previous involvement in tumor angiogenesis. Downregulation of miR-204 was confirmed in an independent cohort of patients and breast cancer cell lines. Gain-of-function analysis indicates that ectopic expression of miR-204 impairs cell proliferation, anchorage-independent growth, migration, invasion, and the formation of 3D capillary networks in vitro. Likewise, in vivo vascularization and angiogenesis were suppressed by miR-204 in a nu/nu mice model. Genome-wide profiling of MDA-MB-231 cells expressing miR-204 revealed changes in the expression of hundred cancer-related genes. Of these, we focused on the study of pro-angiogenic ANGPT1 and TGFβR2. Functional analysis using luciferase reporter and rescue assays confirmed that ANGPT1 and TGFβR2 are novel effectors downstream of miR-204. Accordingly, an inverse correlation between miR-204 and ANGPT1/TGFβR2 expression was found in breast tumors. Knockdown of TGFβR2, but not ANGPT1, impairs cell proliferation and migration whereas inhibition of both genes inhibits angiogenesis. Taken altogether, our findings reveal a novel role for miR-204/ANGPT1/TGFβR2 axis in tumor angiogenesis. We propose that therapeutic manipulation of miR-204 levels may represent a promising approach in breast cancer. PMID:27703260

  18. Variable Star Status of Two Stars: V204 and I-I-39 in M3

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The star I-I-42 (=vZ1390), a cluster member in M3, located near the red edge of the instability strip of the horizontal branch, was discovered by Roberts and Sandage as a low amplitude variable, it was designated as V204 in the "second catalogue of variable stars in globular clusters", but its coordinates given in all versions of this catalogue are wrong since 1955. We argue that V204 is indeed a low amplitude HB variable star, located near to the red edge of the instability strip, with a period of 0.74785d and an amplitude of about 0.04 mag in V. We also find that the red cluster member star I-I-39 is a low amplitude variable with a period of 1.16d and amplitude of about 0.03 mag in V which might be pulsating at the second overtone.

  19. The Application of P204-Cyanex 923-Sulphonating Kerosene in the Solvent Extraction of Indium%P204-Cyanex 923磺化煤油用于铟的萃取和反萃研究

    Institute of Scientific and Technical Information of China (English)

    孙进贺; 贾永忠; 景燕; 王小华; 孟宪党; 徐跃伟

    2011-01-01

    采用正交试验系统研究和对比了高原条件下P204磺化煤油和P204-Cyanex 923磺化煤油对钢的萃取和反萃条件.研究表明,适量添加Cyanex 923可在不影响萃取率的同时,降低有机相对铁的萃取;3 mol/L HCl+1 mol/L ZnCl2溶液对P204-Cyanex 923磺化煤油具有良好的反萃性能.%The compared orthogonal experiments on the conditions of solvent extraction and stripping of indium with P204-sulphonating kerosene and P204-Cyanex 923-sulphonating kerosene were carried out under the high latitude.The results indicated that the solvent extraction of indium was not affected and the extraction of Fe in organic phase was inhibited when the concentration of Cyanex 923 was maintained with a proper ratio.The solution of 3 mol/L HCl+1 mol/L ZnCl2 was an excellent stripping agent for P204-Cyanex 923-sulphonating kerosene.

  20. MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression.

    Science.gov (United States)

    Gao, Rui; Wang, Liming; Sun, Jun; Nie, Kun; Jian, Huiling; Gao, Lei; Liao, Xinhua; Zhang, Haiyuan; Huang, Jin; Gan, Shangquan

    2014-08-25

    Neuritin (Nrn1) is a neurotrophin that plays an important role in nervous system plasticity and repair following nerve injury. MicroRNAs (miRNAs) are a type of small non-coding RNA that regulate nearly all aspects of nerve development and survival, including apoptosis. Here it was found that miR-204 negatively regulates Nrn1 protein expression through direct interaction with Nrn1 transcript. Moreover, miR-204 activates cleaved caspase-3, enhancing the sensitivity of RSC96 Schwann cells to H2O2-induced oxidative stress and apoptosis. Thus, miR-204 expressed at a low level may create a microenvironment suitable for the repair of injured nerves by relieving the inhibition of Nrn1 transcription and stimulating the anti-apoptotic function of Schwann cells. These results provide novel insights into the roles of miR-204 in nerve injury and repair. PMID:25036738

  1. 41 CFR 101-27.204 - Types of shelf-life items.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Types of shelf-life items...-Management of Shelf-Life Materials § 101-27.204 Types of shelf-life items. Shelf-life items are classified as nonextendable (Type I) and extendable (Type II). Type I items have a definite storage life after which the...

  2. Neutron capture at the s-process branching points $^{171}$Tm and $^{204}$Tl

    CERN Multimedia

    Branching points in the s-process are very special isotopes for which there is a competition between the neutron capture and the subsequent b-decay chain producing the heavy elements beyond Fe. Typically, the knowledge on the associated capture cross sections is very poor due to the difficulty in obtaining enough material of these radioactive isotopes and to measure the cross section of a sample with an intrinsic activity; indeed only 2 out o the 21 ${s}$-process branching points have ever been measured by using the time-of-flight method. In this experiment we aim at measuring for the first time the capture cross sections of $^{171}$Tm and $^{204}$Tl, both of crucial importance for understanding the nucleosynthesis of heavy elements in AGB stars. The combination of both (n,$\\gamma$) measurements on $^{171}$Tm and $^{204}$Tl will allow one to accurately constrain neutron density and the strength of the 13C(α,n) source in low mass AGB stars. Additionally, the cross section of $^{204}$Tl is also of cosmo-chrono...

  3. Performance evaluation of Eureka-147 with RS(204, 188) code for mobile multimedia broadcasting

    Science.gov (United States)

    Chang, Seung-Gi; Ha, Victor H. S.; Zhang, Zhiming; Kim, Yongje

    2003-06-01

    The demand for mobile multimedia broadcasting service is increasing consistently as more people expect seamless outdoor connections and communication capabilities. In this paper, we introduce the digital multimedia broadcasting (DMB) system based on Eureka-147 that has been tentatively adopted in Korea. Since Eureka-147 is originally designed for broadcasting digital audio data, it provides a bit error rate (BER) of about 10-4 while the transmission of compressed video data, for example, requires the BER of about 10-9. To deal with this mismatch, the Korean DMB standard is considering the addition of the RS(204,188) coder to Eureka-147. In this paper, we apply the RS(204,188) coder to the Eureka-147 and present the simulation results on the performance of this modified system at various transmission and protection modes. We conclude that the addition of RS(204,188) coder to Eureka-147 in the Korean DMB system results in the satisfactory level of BER for mobile multimedia broadcasting services.

  4. 高精度铅同位素207Pb-204Pb双稀释剂TIMS测试方法%Highly precise Pb isotope analysis by 207Pb-204Pb double spike method using TIMS

    Institute of Scientific and Technical Information of China (English)

    刘希军; 王桂琴; CASTILLO P R; 许继峰; 黄丰; 余红霞; 陈玲

    2013-01-01

    利用热电离质谱(TIMS)和207Pb-204Pb双稀释法测定低含量Pb岩石样品的同位素比值,可以有效校正由质谱分析造成的同位素分馏效应,提高铅同位素比值测定的精度和准确度.本文利用中国科学院广州地球化学研究所Triton TIMS,建立了207Pb-204Pb双稀释剂测试方法,并对Pb含量为5~20 ng的国际标样SRM981进行3个月的TIMS仪器测定,双稀释剂法外部校正后得到的206Pb/204Pb、207Pb/204Pb和208Pb/204Pb外部精度分别为±0.0034、±0.0046和±0.0100 (2sd,n=28).达到或优于其他国际高水平TIMS实验室双稀释剂法测定精度.同时,运用新方法对国际岩石标样AGV-2和BCR-2进行测定,得到的比值分别为:206Pb/204Pb=18.870±0.006、207Pb/204Pb=15.619±0.003、208Pb/204Pb=38.546±0.012和206Pb/204Pb=18.752±0.011、207Pb/204Pb=15.619±0.005、208Pb/204Pb=38.723±0.020,与国际同类实验室测定结果和精度一致,表明该新建方法是可靠的.运用207Pb-204Pb双稀释剂法对岩石样品进行测定,可获得高精度铅同位素比值,尤其对低含量Pb的基性、超基性地质样品测定有很大的优势.%207Pb-204Pb double spike method has been developed at Guangzhou Institute of Geochemistry in order to obtain high quality Pb isotope ratio.This method could effectively correct the mass fractionation effects for Pb isotopic analysis of samples with low Pb concentration by thermal ionization mass spectrometry (TIMS).The minimum amount of Pb per load can be as low as 5×10-9-20×10-9 g,and the analysis method could effectively improve precision and accuracy.In this study,we determined Pb isotopic composition of SRM 981 using 207Pb-204Pb double spike,the external precisions of 206Pb/204Pb,207Pb/204Pb and 208Pb/204Pb are ±0.0034,±0.0046 and ±0.0100 (2×sd,n =28,t =3 months).Meanwhile we have analyzed standard reference rocks of USGS:AGV-2 and BCR-2 by using the same procedure,the isotopic ratios for AGV-2 and BCR-2 are 206pb/204pb =18.870

  5. M5640+P204+P507萃取净化镍电解液%Nickel Sulphate Electrolyte Extraction Purified by M5640+P204+P507

    Institute of Scientific and Technical Information of China (English)

    李学鹏

    2011-01-01

    The extraction purification of nickel sulphate electrolyte was studied. M5640 was used to remove Cu2+. The extraction rate was higher than 99. 83% and the content of Cu2+ was lower than 0. 1 mg/L on the conditions including pH = 3. 0, O/A=l/1, volume concentration of M5640 to be 15%, and the reaction time as 2 min. Then, P204 was used to remove other impurities. The conditions included pH = 4. 0, O/A=2/1, volume concentration of P204 to be 25%, and reaction time as 7 min. At last, raffinate was purified with P507 on the following conditions that 75 % P507 was saponificated by sodium hydroxide solution, the concentration of Co2+ was increased to 4. 19 g/L (Co/Ni=l/10), pH = 4~5 and extraction series was 4. The final raffinate can satisfied the standard of 5N nickel.%对硫酸镍电解液的萃取净化除杂进行了系统研究.采用M5640对铜离子进行除杂的条件为:pH3.0,相比1∶1,萃取剂体积浓度15%,振荡时间5 min,在此条件下铜离子的萃取率大于99.83%,萃余液含铜已达到5N镍电解液标准要求.去除铜离子之后,采用P204对电解液进行除杂,试验条件:pH4.0,相比2∶1,萃取剂体积浓度25%,振荡时间7 min,温度20℃.萃余液再用P507萃取除杂,试验条件:用氢氧化钠溶液均相制皂75%,提高待萃液当中钴离子的含量至4.19 g/L,即Co/Ni为1/10,4级萃取,控制水相pH 4~5.副终萃余液中各杂质离子的含量均达到生产5N镍的电解液标准.

  6. Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels*

    Science.gov (United States)

    Miller, Melissa; Shi, Jie; Zhu, Yingmin; Kustov, Maksym; Tian, Jin-bin; Stevens, Amy; Wu, Meng; Xu, Jia; Long, Shunyou; Yang, Pu; Zholos, Alexander V.; Salovich, James M.; Weaver, C. David; Hopkins, Corey R.; Lindsley, Craig W.; McManus, Owen; Li, Min; Zhu, Michael X.

    2011-01-01

    Transient receptor potential canonical (TRPC) channels are Ca2+-permeable nonselective cation channels implicated in diverse physiological functions, including smooth muscle contractility and synaptic transmission. However, lack of potent selective pharmacological inhibitors for TRPC channels has limited delineation of the roles of these channels in physiological systems. Here we report the identification and characterization of ML204 as a novel, potent, and selective TRPC4 channel inhibitor. A high throughput fluorescent screen of 305,000 compounds of the Molecular Libraries Small Molecule Repository was performed for inhibitors that blocked intracellular Ca2+ rise in response to stimulation of mouse TRPC4β by μ-opioid receptors. ML204 inhibited TRPC4β-mediated intracellular Ca2+ rise with an IC50 value of 0.96 μm and exhibited 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. In whole-cell patch clamp recordings, ML204 blocked TRPC4β currents activated through either μ-opioid receptor stimulation or intracellular dialysis of guanosine 5′-3-O-(thio)triphosphate (GTPγS), suggesting a direct interaction of ML204 with TRPC4 channels rather than any interference with the signal transduction pathways. Selectivity studies showed no appreciable block by 10–20 μm ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons. In isolated guinea pig ileal myocytes, ML204 blocked muscarinic cation currents activated by bath application of carbachol or intracellular infusion of GTPγS, demonstrating its effectiveness on native TRPC4 currents. Therefore, ML204 represents an excellent novel tool for investigation of TRPC4 channel function and may facilitate the development of therapeutics targeted to TRPC4. PMID:21795696

  7. Networking automation of ECI’s G-204 electronic engineering laboratory

    Directory of Open Access Journals (Sweden)

    Hernán Paz Penagos

    2010-04-01

    Full Text Available Increased use (by students and teachers of the “Escuela Colombiana de Ingeniería Julio Garavito” Electronic Engineering laboratories during the last year has congested access to these laboratories; the School’s Electronic Engineering (Ecitronica programme’s applied Electronic studies’ centre research group thus proposed, designed and developed a research prolect taking advantage of G building’s electrical distribution to offer access facilities, laboratory equipment control, energy saving and improved service quality. The G-204 laboratory’s network sys- tem will have an access control subsystem with client–main computer architecture. The latter consists of a user, schedule, group and work-bank database; the user is connected from any computer (client to the main computer through Internet to reserve his/her turn at laboratory practice by selecting the schedule, group, work-bank, network type required (1Ф or 3Ф and registering co-workers. Access to the G-204 laboratory on the day and time of practice is made by means of an intelligent card reader. Information of public interest produced and controlled by the main computer is displayed on three LCD screens located on one of G building’s second floor walls, as is an electronic clock. The G-204 laboratory temperature and time are continually updated. Work-banks are enabled or disabled by the main computer; the work banks are provided with power (beginning of practice or disconnected (end of practice or due to eventualities to protect the equipment, save energy, facilitate monitors and supervise the logistics of the state of the equipment at the end of each practice. The research group was organised into Transmission Line and Applications sub-groups. Power Line Communications PLC technology was used for to exploring digital modulation alternatives, coding and detecting errors, coupling, data transmission protocols and new applications, all based on channel estimation (networking

  8. Residual Waste from Hanford Tanks 241-C-203 and 241-C-204. 2. Contaminant Release Model

    International Nuclear Information System (INIS)

    Fusion analyses, water leaches, selective extractions, empirical solubility measurements, and thermodynamic modeling were used with results from solid-phase characterization studies [see companion paper (1)] to determine total concentrations, contaminant-phase associations, and develop contaminant release models for residual sludge from single-shell underground waste tanks 241-C-203 and 241-C-204 at the U.S. Department of Energy?s Hanford Site in southeastern Washington state. U and Tc are primary contaminants of concern because of their long half-lives and their generally high mobility in oxidizing soil and groundwater environments. Uranium release was determined to be controlled by two phases; ?ejkaite [Na4(UO2)(CO3)3] and poorly crystalline Na2U2O7 [or clarkeite Na[(UO2)O(OH)](H2O)0-1] which were identified in C-203 and C-204 sludge samples (1). U release was determined to occur in three stages from these phases. In the first stage, U release will be controlled by the solubility of ?ejkaite, which is suppressed by high concentrations of sodium released from dissolution of NaNO3 in the residual sludges. Equilibrium solubility calculations indicate the U released during this stage will have a maximum concentration of 0.021 M. When all the NaNO3 has dissolved from the sludge, the solubility of the remaining ?ejkaite will increase to 0.28 M. After ?ejkaite has completely dissolved, the maximum concentration of U released is expected to be controlled by the solubility of Na2U2O7 at a concentration of 3.0 ? 10-5 M. For Tc, a significant fraction of its concentration in the residual sludge was determined to be relatively insoluble (20 wt% for C-203 and 80 wt% for C-204). Because of the low concentrations of Tc in these sludge materials, the characterization studies did not identify any discrete Tc solids phases. Therefore, release of the readily soluble fraction of Tc was assumed to be controlled by the solubility of NaTcO4 at 7.1 M. Selective extraction results

  9. The Mouse Clock Locus: Sequence and Comparative Analysis of 204 Kb from Mouse Chromosome 5

    OpenAIRE

    Wilsbacher, Lisa D.; Sangoram, Ashvin M.; Antoch, Marina P.; Takahashi, Joseph S.

    2000-01-01

    The Clock gene encodes a basic helix-loop-helix (bHLH)–PAS transcription factor that regulates circadian rhythms in mice. We previously cloned Clock in mouse and human using a battery of behavioral and molecular techniques, including shotgun sequencing of two bacterial artificial chromosome (BAC) clones. Here we report the finished sequence of a 204-kb region from mouse chromosome 5. This region contains the complete loci for the Clock and Tpardl (pFT27) genes, as well as the 3′ partial locus...

  10. Corrective Action Decision Document for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada, Rev. No. 0

    Energy Technology Data Exchange (ETDEWEB)

    Robert Boehlecke

    2004-04-01

    The six bunkers included in CAU 204 were primarily used to monitor atmospheric testing or store munitions. The ''Corrective Action Investigation Plan (CAIP) for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada'' (NNSA/NV, 2002a) provides information relating to the history, planning, and scope of the investigation; therefore, it will not be repeated in this CADD. This CADD identifies potential corrective action alternatives and provides a rationale for the selection of a recommended corrective action alternative for each CAS within CAU 204. The evaluation of corrective action alternatives is based on process knowledge and the results of investigative activities conducted in accordance with the CAIP (NNSA/NV, 2002a) that was approved prior to the start of the Corrective Action Investigation (CAI). Record of Technical Change (ROTC) No. 1 to the CAIP (approval pending) documents changes to the preliminary action levels (PALs) agreed to by the Nevada Division of Environmental Protection (NDEP) and DOE, National Nuclear Security Administration Nevada Site Office (NNSA/NSO). This ROTC specifically discusses the radiological PALs and their application to the findings of the CAU 204 corrective action investigation. The scope of this CADD consists of the following: (1) Develop corrective action objectives; (2) Identify corrective action alternative screening criteria; (3) Develop corrective action alternatives; (4) Perform detailed and comparative evaluations of corrective action alternatives in relation to corrective action objectives and screening criteria; and (5) Recommend and justify a preferred corrective action alternative for each CAS within CAU 204.

  11. The Interferon-inducible p204 Protein Regulate Cardiac Differentiation:Mechanisms and Application Prospect%干扰素诱导蛋白p204调节心肌分化的机制及应用前景

    Institute of Scientific and Technical Information of China (English)

    宋方; 吴强

    2011-01-01

    干扰素诱导蛋白p200家族蛋白包括6种鼠类及4种人类家族成员,具有共同的特征结构,广泛参与调节细胞增殖和分化、衰老和凋亡,在自身免疫反应、抗病毒及抗癌等领域发挥着重要的作用.内源性的p200家族蛋白鼠p204在心肌及骨骼肌表达最高,提示其在肌分化中起着重要作用.本文联系p204的分子结构及调节细胞生长与分化的功能,阐述p204促骨骼肌成肌细胞及胚胎癌细胞分化的机制,及对心肌损伤后心肌再生的应用前景.%The interferon-inducible protein 200 family (p200) proteins, which have several common characteristic structures and are highly homologous to one another, include 6 kinds of murine and 4 kinds of human family members, are widely involved in regulating cell proliferation and differentiation, senescence and apoptosis,playing important roles in the autoimmune response, anti-virus, anti-cancer and other fields.The endogenous murine p204 of p200 family proteins has the highest expression in heart and skeletal muscle, suggesting that it plays an important role in muscle differentiation.This article links the molecular structure of p204 and its functions of regulation of cell growth and differentiation, describes the mechanisms of p204 to promote skeletal myoblast,embryonal carcinoma cell differentiation and its application prospect for myocardial regeneration after cardiac injury.

  12. Analysis of test result for 204 brucellosis cases%204例布氏杆菌病实验室检测结果分析

    Institute of Scientific and Technical Information of China (English)

    宋耀丽; 张俊杰; 牛国永; 刘伟伟

    2015-01-01

    Objective Based on the result of laboratory test, the diagnosis for brucelosis was determined, in order to sup-port of trend prediction and making control measures for brucelosis.Methods According to the experimental diagnostic criteria for brucellosis, the combined detection of tiger red plate agglutination test ( RBPT) and serum agglutination test ( SAT) was performed in detection of brucella antibody on infected cases, suspected cases and related conective individu-als.Results The brucella antibody were detected in 204 cases among all of 470 subjects,with a positive rate 43.4%. Among the brucellosis cases, the ratio of male to female was 1.62 ∶1, cases in 40 to 69 years age accounted for 75.49%, farmers accounted for 40.69%, slaughter workers accounted for 32.35%.Conclusions It is to strengthen control brucel-losis measures to the individuals engaged in aquaculture and animal husbandry, and improve their awareness of self-protec-tion.%目的:通过实验室检测,发现布氏杆菌感染者,掌握疫情动态,为预测布氏杆菌病流行趋势、制订防治对策提供依据。方法根据布氏杆菌病实验室诊断标准,利用虎红平板凝集试验(RBPT)和试管凝集试验(SAT)相结合的试验方法,对布氏杆菌病疑似病例和有接触史等的人员进行布氏杆菌抗体检测。结果在470例监测对象中,布氏杆菌抗体阳性病例204例,阳性率43.4%。在阳性病例中,男女性别比为1.62∶1;40~69岁年龄组占75.49%;畜牧养殖人员占40.69%,屠宰作业者占32.35%。结论应加强对养殖业和畜牧业人员的预防控制工作,提高其自我防护意识。

  13. 农村高血压健康管理204例临床体会%204 cases of clinical experience of Rural Hypertension Health Management

    Institute of Scientific and Technical Information of China (English)

    李立华

    2015-01-01

    目的:对农村高血压患者实行规范化健康管理,从而有效提高患者血压达标率。方法:以204例我辖区农村高血压患者为对象,通过1年的健康管理,包括戒烟限酒,健康饮食,限制钠盐摄入,适量运动,控制体重,健康知识宣教,心理疏导以及合理用药,并收集相关资料进行自身前后比较。结果:高血压患者纳入健康管理,通过健康教育和干预指导,有效控制血压,减少并发症。患者诊断标准知晓率、防治知识知晓率、规范服药率、血压达标率之间差异有统计学意义。结论:对农村高血压患者实行持续系统的健康管理切实可行,效果明显。值得在农村社区内开展。%Objective:To increase the standard rate of blood pressure by executing normal health management.Methods:Aiming at 204 cases of rural hypertention patients in our region by health management for one year,including quitting smoking and setting limit on alcohol,moderate exercise,weight control,health knowledge propaganda, psychological counseling and rational use of drugs, and collecting related data to make own comparison.Results:Bring these hypertention patients into health management,control blood pressure effectively and reduce the complications by health education and intervention guidance.Making the difference of the awareness rate of diagnostic criteria and prevention knowledge,standardized medication rate,and standard rate of blood pressure meaningful on statistics.Conclusion:Continuous and systematic rural hypertention health management is feasible and has a striking effect.It deserves to develop in rural region.

  14. Clinical analysis of 204 children infected by mouse typhus salmonella%204例儿童感染鼠伤寒沙门氏菌临床分析

    Institute of Scientific and Technical Information of China (English)

    梁燕霞; 李小南; 伍绍东

    2016-01-01

    Objective To retrospectively analyze drug resistance of children infected mouse typhus salmonella, and to guide rational clinical drug use.Methods Salmonella from 420 children with salmonella diarrhea were separated from faeces, and their serum type was confirmed by serology agglutination test. Kerby-Bauer disk diffusion test was used to detect sensitivity to antibacterial agents.Results Among 420 separated salmonella from faeces, there were 204 mouse typhus salmonella cases, accounting for 48.57%, which was resistant to multiple antibiotics. It showed complete resistance to sulfonamides (100.0%), followed by ampicillin (93.6%), streptomycin (94.1%) and tetracycline (98.0%) with high resistance rates. Ceftazidime (2.0%) and ciprofloxacin (2.0%) had the lowest resistance rates, and others showed various resistance.Conclusion Mouse typhus salmonella shows resistance for various antibiotics, along with multi-drug resistance. Rational application of antibiotics is necessary in accordance with drug sensitivity outcomes.%目的:回顾分析临床儿童感染鼠伤寒沙门氏菌耐药情况,指导临床合理用药。方法420例沙门氏菌腹泻儿童,从其粪便中分离沙门氏菌,采用血清学凝集试验确定沙门氏菌血清型,再采用Kerby-Bauer纸片扩散法检测其对抗菌药物的敏感性。结果从腹泻儿童粪便分离出420例沙门氏菌中,鼠伤寒沙门氏菌204例,占48.57%。鼠伤寒沙门氏菌对多种抗生素产生耐药,对磺胺类药全部耐药(100.0%),耐药率较高的还有氨苄西林(93.6%),链霉素(94.1%),四环素(98.0%);耐药率最低的是头孢他啶(2.0%),环丙沙星(2.0%),其余出现不同程度的耐药性。结论鼠伤寒沙门氏菌对多种抗生素产生耐药性,并出现多重耐药性,临床上需根据药敏结果合理使用抗生素。

  15. 41 CFR 302-4.204 - If my spouse does not accompany me but travels unaccompanied at a different time, what per diem...

    Science.gov (United States)

    2010-07-01

    ... accompany me but travels unaccompanied at a different time, what per diem rate will he/she receive? 302-4.204 Section 302-4.204 Public Contracts and Property Management Federal Travel Regulation System... my spouse does not accompany me but travels unaccompanied at a different time, what per diem...

  16. 9 CFR 381.204 - Marking of poultry products offered for entry; official import inspection marks and devices.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Marking of poultry products offered...; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Imported Poultry Products § 381.204 Marking of poultry products offered for...

  17. 20 CFR 718.204 - Total disability and disability causation defined; criteria for determining total disability and...

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Total disability and disability causation defined; criteria for determining total disability and total disability due to pneumoconiosis. 718.204... MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED STANDARDS FOR DETERMINING COAL MINERS' TOTAL...

  18. External bremsstrahlung spectra excited by 204Tl β particles in thick targets

    Science.gov (United States)

    Powar, M. S.; Ahmad, Salim; Singh, M.

    1980-06-01

    Spectral distributions of bremsstrahlung produced by 204Tl β particles in thick targets of Perspex, aluminum, copper, tin, and lead have been measured in a sandwich geometry. The contributions of internal bremsstrahlung produced along with the β particles have been determined by magnetic field deflection as well as the Z=O extrapolation method. Experimental results agree with Bethe-Heitler Born-approximation theory, corrected for Coulomb-field effects for low- and medium-Z targets, but show 25% positive deviation for high-Z targets. Again it is found that the bremsstrahlung produced in low-Z targets like Perspex is comparable with internal bremsstrahlung, and the corrections for its contribution to measurements by earlier workers can lead to large uncertainties.

  19. Breakup mechanisms for 7Li + 197Au, 204Pb systems at sub-barrier energies

    Directory of Open Access Journals (Sweden)

    Luong D.H.

    2013-12-01

    Full Text Available Coincidence measurements of breakup fragments were carried out for the 7Li + 197Au and 204Pb systems at sub-barrier energies. The mechanisms triggering breakup, and time-scales of each process, were identified through the reaction Q-values and the relative energy of the breakup fragments. Binary breakup of 7Li were found to be predominantly triggered by nucleon transfer, with p-pickup leading to 8Be → α + α decay being the preferred breakup mode. From the time-scales of each process, the coincidence yields were separated into prompt and delayed components, allowing the identification of breakup process important in the suppression of complete fusion of 7Li at above-barrier energies.

  20. Distinction of [220] and [204] textures of Cu(In,Ga)Se2 film and their growth behaviors depending on substrate nature and Na incorporation

    International Nuclear Information System (INIS)

    For better understanding of the structural property of polycrystalline tetragonal Cu(In,Ga)Se2 (CIGS) thin films grown on soda-lime glass, it is necessary to characterize the [220]- and [204]-oriented textures clearly that are related to the different physical properties. However, the distinction between the [220]- and [204]-oriented textures is very difficult because of their nearly identical plane spacings and atomic arrangements. Using X-ray diffraction techniques of high resolution θ–2θ scanning and reciprocal space mapping, we distinguished the [220]- and [204]-oriented textures of CIGS films and observed that the behaviors of [220] and [204] textures independently depended on both substrate nature and Na presence. We report the Na- and substrate-related dependence of the physical properties of the CIGS film was attributed to the independent growth behaviors of the [220] and [204] textures in the CIGS. - Highlights: • We investigated [220]- and [204]-oriented textures of Cu(In,Ga)Se2 (CIGS) films. • X-ray diffraction methods distinguished two textures. • The growth behaviors were influenced by underlying substrate and Na. • The [220] and [204] textures in CIGS should be differentially observed

  1. Distinction of [220] and [204] textures of Cu(In,Ga)Se{sub 2} film and their growth behaviors depending on substrate nature and Na incorporation

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Dae-Hyung, E-mail: dhcho@etri.re.kr [IT Components and Materials Industry Technology Research Department, Electronics and Telecommunications Research Institute (ETRI), 218 Gajeongno, Yuseong-gu, Daejeon 305-700 (Korea, Republic of); Kim, Jeha [Department of Solar & Energy Engineering, Cheongju University, 298 Daeseongro, Sangdang-gu, Cheongju, Chungbuk 360-764 (Korea, Republic of); Chung, Yong-Duck [IT Components and Materials Industry Technology Research Department, Electronics and Telecommunications Research Institute (ETRI), 218 Gajeongno, Yuseong-gu, Daejeon 305-700 (Korea, Republic of); Korea University of Science and Technology (UST), 217 Gajeongno, Yuseong-gu, Daejeon 305-350 (Korea, Republic of)

    2015-08-31

    For better understanding of the structural property of polycrystalline tetragonal Cu(In,Ga)Se{sub 2} (CIGS) thin films grown on soda-lime glass, it is necessary to characterize the [220]- and [204]-oriented textures clearly that are related to the different physical properties. However, the distinction between the [220]- and [204]-oriented textures is very difficult because of their nearly identical plane spacings and atomic arrangements. Using X-ray diffraction techniques of high resolution θ–2θ scanning and reciprocal space mapping, we distinguished the [220]- and [204]-oriented textures of CIGS films and observed that the behaviors of [220] and [204] textures independently depended on both substrate nature and Na presence. We report the Na- and substrate-related dependence of the physical properties of the CIGS film was attributed to the independent growth behaviors of the [220] and [204] textures in the CIGS. - Highlights: • We investigated [220]- and [204]-oriented textures of Cu(In,Ga)Se{sub 2} (CIGS) films. • X-ray diffraction methods distinguished two textures. • The growth behaviors were influenced by underlying substrate and Na. • The [220] and [204] textures in CIGS should be differentially observed.

  2. Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization.

    Directory of Open Access Journals (Sweden)

    J Saadi Imam

    Full Text Available Increasing evidence suggests that chromosomal regions containing microRNAs are functionally important in cancers. Here, we show that genomic loci encoding miR-204 are frequently lost in multiple cancers, including ovarian cancers, pediatric renal tumors, and breast cancers. MiR-204 shows drastically reduced expression in several cancers and acts as a potent tumor suppressor, inhibiting tumor metastasis in vivo when systemically delivered. We demonstrated that miR-204 exerts its function by targeting genes involved in tumorigenesis including brain-derived neurotrophic factor (BDNF, a neurotrophin family member which is known to promote tumor angiogenesis and invasiveness. Analysis of primary tumors shows that increased expression of BDNF or its receptor tropomyosin-related kinase B (TrkB parallel a markedly reduced expression of miR-204. Our results reveal that loss of miR-204 results in BDNF overexpression and subsequent activation of the small GTPase Rac1 and actin reorganization through the AKT/mTOR signaling pathway leading to cancer cell migration and invasion. These results suggest that microdeletion of genomic loci containing miR-204 is directly linked with the deregulation of key oncogenic pathways that provide crucial stimulus for tumor growth and metastasis. Our findings provide a strong rationale for manipulating miR-204 levels therapeutically to suppress tumor metastasis.

  3. P204从大洋富钴结壳浸出液中萃取锌%Application of P204 in Hydrometallurgy of Ocean Cobalt-rich Crust

    Institute of Scientific and Technical Information of China (English)

    汪胜东; 蒋讯雄; 蒋开喜; 范艳青

    2006-01-01

    研究用P204做萃取剂,硫酸做反萃剂,从大洋富钴结壳常温常压硫酸快速浸出液中综合回收锌的工艺过程,考察相比、平衡水相pH等因素对P204萃取锌的影响.优化出的萃取工艺条件为有机相组成为10%P204+90%煤油(体积百分数),皂化率70%,室温,相比(O/A)=1/10,出口水相pH=3~3.1,萃取级数为7级,每级混合时间5min.经过7级逆流萃取、4级洗涤、3级反萃后,可以得到符合电解沉积要求的硫酸锌溶液.

  4. Neutron metrology in the HFR. Irradiation of vanadium alloys. Experiment R204-7/8/9 (VABONA)

    International Nuclear Information System (INIS)

    The irradiation experiment R204-7/8/9 is part of a material research program VABONA in which the radiation damage is investigated of different vanadium alloys. The experiment deals with the irradiation of vanadium specimens α-implanted at the cyclotron in Ispra. The irradiation has been performed in a SIENA capsule in the HFR Petten at three different temperatures (873, 973 and 1073 K). The irradiation took place in position C5 during seven HFR operating cycles. The target damage level was 5 dpa (displacements per atom). This report presents the final neutron metrology results obtained from activation monitors in the three specimen holders, coded as R204-7/8/9. Data about the number of displacements per atom are also included. The main results of the thermal and fast neutron fluence measurements are presented. (orig.)

  5. A theoretical study of energy spectra and transition probabilities of 200–204Hg isotopes in transitional region of IBM

    International Nuclear Information System (INIS)

    In this paper, by using the SO(6) representation of eigenstates and transitional Interacting Boson Model (IBM) Hamiltonian, the evolution from prolate to oblate shapes along the chain of Hg isotopes is studied. Parameter-free (up to overall scale factors) predictions for spectra and B(E2) transition rates are found to be in good agreement with experimental data for 200–204Hg isotopes which are supported to be located in this transitional region. (author)

  6. Evaluation of Energy-Related Inventions Program: An Empirical Analysis of 204 Inventions; TOPICAL

    International Nuclear Information System (INIS)

    This report is an evaluation of the Energy-Related Inventions Program (ERIP). It assess the program's effectiveness and impacts, characterizes participating inventions and inventors, and identifies correlates of successful commercialization in order to suggest possible improvements. Seventy of the 204 ERIP inventions that were studied were successfully introduced into the market, accounting for more than$200M in sales from 1976 through 1984. During 1984, 921 full-time equivalent employees were supported directly by ERIP inventors or their licensees. (Estimates of indirect economic impacts are also contained in the report.) Data on patterns of fund raising clearly show a need for assistance by programs like ERIP. Commercially successful inventors shared several traits. They had less formal education, fewer patents, more work experience in small firms, more outside funding early in their work, more shared responsibility with others for invention development, more management experience, and greater previous experience with starting new businesses. Recommendations are made regarding: (1) priorities for allocating ERIP grants; (2) improved efficiency of the NBS/DOE operations; (3) delivery of technical and commercialization assistance to grant recipients; and (4) further evaluation research

  7. Evaluation of Energy-Related Inventions Program: An Empirical Analysis of 204 Inventions

    Energy Technology Data Exchange (ETDEWEB)

    Brown, M.A.

    1987-01-01

    This report is an evaluation of the Energy-Related Inventions Program (ERIP). It assesses the program's effectiveness and impacts, characterizes participating inventions and inventors, and identifies correlates of successful commercialization in order to suggest possible improvements. Seventy of the 204 ERIP inventions that were studied were successfully introduced into the market, accounting for more than $200M in sales from 1976 through 1984. During 1984, 921 full-time equivalent employees were supported directly by ERIP inventors or their licensees. (Estimates of indirect economic impacts are also contained in the report.) Data on patterns of fund raising clearly show a need for assistance by programs like ERIP. Commercially successful inventors shared several traits. They had less formal education, fewer patents, more work experience in small firms, more outside funding early in their work, more shared responsibility with others for invention development, more management experience, and greater previous experience with starting new businesses. Recommendations are made regarding: (1) priorities for allocating ERIP grants; (2) improved efficiency of the NBS/DOE operations; (3) delivery of technical and commercialization assistance to grant recipients; and (4) further evaluation research.

  8. Hanford Tanks 241-C-203 and 241-C-204: Residual Waste Contaminant Release Model and Supporting Data

    International Nuclear Information System (INIS)

    This report describes the development of release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. Key results from this work are (1) future releases from the tanks of the primary contaminants of concern (99Tc and 238U) can be represented by relatively simple solubility relationships between infiltrating water and solid phases containing the contaminants; and (2) high percentages of technetium-99 in the sludges (20 wt% in C-203 and 75 wt% in C-204) are not readily water leachable, and, in fact, are very recalcitrant. This is similar to results found in related studies of sludges from Tank AY-102. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for the U.S. Department of Energy

  9. Hanford Tanks 241-C-203 and 241 C 204: Residual Waste Contaminant Release Model and Supporting Data

    International Nuclear Information System (INIS)

    This report was revised in May 2007 to correct 90Sr values in Chapter 3. The changes were made on page 3.9, paragraph two and Table 3.10; page 3.16, last paragraph on the page; and Tables 3.21 and 3.31. The rest of the text remains unchanged from the original report issued in October 2004. This report describes the development of release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. Key results from this work are (1) future releases from the tanks of the primary contaminants of concern (99Tc and 238U) can be represented by relatively simple solubility relationships between infiltrating water and solid phases containing the contaminants; and (2) high percentages of technetium-99 in the sludges (20 wt% in C-203 and 75 wt% in C-204) are not readily water leachable, and, in fact, are very recalcitrant. This is similar to results found in related studies of sludges from Tank AY-102. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for the U.S. Department of Energy.

  10. Corrective Action Decision Document for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada: Revision 0, Including Errata Sheet

    Energy Technology Data Exchange (ETDEWEB)

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2004-04-01

    This Corrective Action Decision Document identifies the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's corrective action alternative recommendation for each of the corrective action sites (CASs) within Corrective Action Unit (CAU) 204: Storage Bunkers, Nevada Test Site (NTS), Nevada, under the Federal Facility Agreement and Consent Order. An evaluation of analytical data from the corrective action investigation, review of current and future operations at each CAS, and a detailed comparative analysis of potential corrective action alternatives were used to determine the appropriate corrective action for each CAS. There are six CASs in CAU 204, which are all located between Areas 1, 2, 3, and 5 on the NTS. The No Further Action alternative was recommended for CASs 01-34-01, 02-34-01, 03-34-01, and 05-99-02; and a Closure in Place with Administrative Controls recommendation was the preferred corrective action for CASs 05-18-02 and 05-33-01. These alternatives were judged to meet all requirements for the technical components evaluated as well as applicable state and federal regulations for closure of the sites and will eliminate potential future exposure pathways to the contaminated media at CAU 204.

  11. Hanford Tanks 241-C-203 and 241 C 204: Residual Waste Contaminant Release Model and Supporting Data

    Energy Technology Data Exchange (ETDEWEB)

    Deutsch, William J.; Krupka, Kenneth M.; Lindberg, Michael J.; Cantrell, Kirk J.; Brown, Christopher F.; Schaef, Herbert T.

    2007-05-23

    This report was revised in May 2007 to correct 90Sr values in Chapter 3. The changes were made on page 3.9, paragraph two and Table 3.10; page 3.16, last paragraph on the page; and Tables 3.21 and 3.31. The rest of the text remains unchanged from the original report issued in October 2004. This report describes the development of release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. Key results from this work are (1) future releases from the tanks of the primary contaminants of concern (99Tc and 238U) can be represented by relatively simple solubility relationships between infiltrating water and solid phases containing the contaminants; and (2) high percentages of technetium-99 in the sludges (20 wt% in C-203 and 75 wt% in C-204) are not readily water leachable, and, in fact, are very recalcitrant. This is similar to results found in related studies of sludges from Tank AY-102. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for the U.S. Department of Energy.

  12. Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1.

    Science.gov (United States)

    Vikram, Ajit; Kim, Young-Rae; Kumar, Santosh; Li, Qiuxia; Kassan, Modar; Jacobs, Julia S; Irani, Kaikobad

    2016-01-01

    Gut microbiota promotes atherosclerosis, and vascular endothelial dysfunction, signalled by impaired endothelium-dependent vasorelaxation, is an early marker of atherosclerosis. Here we show that vascular microRNA-204 (miR-204) expression is remotely regulated by the microbiome, and impairs endothelial function by targeting the Sirtuin1 lysine deacetylase (Sirt1). MiR-204 is downregulated, while Sirt1 is upregulated, in aortas of germ-free mice. Suppression of gut microbiome with broad-spectrum antibiotics decreases miR-204, increases Sirt1 and bioavailable vascular nitric oxide, and improves endothelium-dependent vasorelaxation in mouse aortas. Antibiotics curtail aortic miR-204 upregulation, and rescue decline of aortic Sirt1 and endothelium-dependent vasorelaxation, triggered by high-fat diet feeding. Improvement of endothelium-dependent vasorelaxation by antibiotics is lost in mice lacking endothelial Sirt1. Systemic antagonism of miR-204 rescues impaired endothelium-dependent vasorelaxation and vascular Sirt1, and decreases vascular inflammation induced by high-fat diet. These findings reveal a gut microbe-vascular microRNA-Sirtuin1 nexus that leads to endothelial dysfunction. PMID:27586459

  13. Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis.

    Directory of Open Access Journals (Sweden)

    Younghee Lee

    2010-04-01

    Full Text Available Due to the large number of putative microRNA gene targets predicted by sequence-alignment databases and the relative low accuracy of such predictions which are conducted independently of biological context by design, systematic experimental identification and validation of every functional microRNA target is currently challenging. Consequently, biological studies have yet to identify, on a genome scale, key regulatory networks perturbed by altered microRNA functions in the context of cancer. In this report, we demonstrate for the first time how phenotypic knowledge of inheritable cancer traits and of risk factor loci can be utilized jointly with gene expression analysis to efficiently prioritize deregulated microRNAs for biological characterization. Using this approach we characterize miR-204 as a tumor suppressor microRNA and uncover previously unknown connections between microRNA regulation, network topology, and expression dynamics. Specifically, we validate 18 gene targets of miR-204 that show elevated mRNA expression and are enriched in biological processes associated with tumor progression in squamous cell carcinoma of the head and neck (HNSCC. We further demonstrate the enrichment of bottleneckness, a key molecular network topology, among miR-204 gene targets. Restoration of miR-204 function in HNSCC cell lines inhibits the expression of its functionally related gene targets, leads to the reduced adhesion, migration and invasion in vitro and attenuates experimental lung metastasis in vivo. As importantly, our investigation also provides experimental evidence linking the function of microRNAs that are located in the cancer-associated genomic regions (CAGRs to the observed predisposition to human cancers. Specifically, we show miR-204 may serve as a tumor suppressor gene at the 9q21.1-22.3 CAGR locus, a well established risk factor locus in head and neck cancers for which tumor suppressor genes have not been identified. This new strategy

  14. 干扰素诱导蛋白p204表达变化对大鼠血管平滑肌细胞增殖及p21表达的影响%Effects of p204 expression on expression of p21 and proliferation of vascular smooth muscle cells in rats

    Institute of Scientific and Technical Information of China (English)

    龙向淑; 吴强; 宋方

    2012-01-01

    目的:观察干扰素诱导蛋白p204对鼠血管平滑肌细胞(VSMCs)增殖及p21表达的影响,探讨p204在VSMCs增殖调控中的作用及可能机制.方法:应用干扰素α(IFN-α)处理和p204基因(Ifi204)的小干扰RNA(siRNA)瞬时干预体外培养的VSMCs,用MTT法测定细胞活力反映细胞增殖,流式细胞仪分析细胞周期,用半定量RT-PCR 法和Western blotting 分别检测p204和p21的mRNA和蛋白表达.结果:IFN-α可诱导鼠VSMCs p204 mRNA和蛋白表达上调,降低VSMCs细胞活力和细胞周期G1/S转换,伴p21 mRNA和蛋白表达上调.转染Ifi204 siRNA可抑制p204和p21表达,提高VSMCs细胞活力和促进细胞周期G1/S转换.结论:p204表达可抑制鼠VSMCs的增殖,该效应可能与激活p21表达有关.%AIM: To observe the effect of interferon - inducible protein 204 ( p204 ) on the expression of p21 and proliferation of vascular smooth muscle cells ( VSMCs ) in rats. METHODS: Interferon alpha ( IFN - a ) and small interference RNA ( siRNA ) targeting p204 gene ( Ifi204 ) was used to intervene cultured VSMCs in vitro instantaneously, then the cell vitality was determined by MTT assay to reflect the cell proliferation. The cell cycle was analyzed by flow cy-tometry. The expression of p204 and p21 at mRNA and protein levels was determined by semi - quantitative RT - PCR and Western blotting. RESULTS: In rat VSMCs, IFN - a. Induced the increase in the expression of p204 at mRNA and protein levels, reduced the cell vitality and the G,/S phase transition, and up - regulated the expression of p21 at mRNA and protein levels. Transfection of Ifi204 siRNA restrained the expression of p204 and p21, increased the cell vitality and promoted the G1 /S phase transition. CONCLUSION: The expression of p204 restrains the proliferation of rat VSMCs, probably by activating the expression of p21.

  15. Cavity residue leucine 95 and channel residues glutamine 204, aspartic acid 211, and phenylalanine 269 of toluene o-xylene monooxygenase influence catalysis.

    Science.gov (United States)

    Kurt, Cansu; Sönmez, Burcu; Vardar, Nurcan; Yanık-Yıldırım, K Cansu; Vardar-Schara, Gönül

    2016-09-01

    Structural analysis of toluene-o-xylene monooxygenase (ToMO) hydroxylase revealed the presence of three hydrophobic cavities, a channel, and a pore leading from the protein surface to the active site. Here, saturation mutagenesis was used to investigate the catalytic roles of alpha-subunit (TouA) second cavity residue L95 and TouA channel residues Q204, D211, and F269. By testing the substrates toluene, phenol, nitrobenzene, and/or naphthalene, these positions were found to influence the catalytic activity of ToMO. Several regiospecific variants were identified from TouA positions Q204, F269, and L95. For example, TouA variant Q204H had the regiospecificity of nitrobenzene changed significantly from 30 to 61 % p-nitrophenol. Interestingly, a combination of mutations at Q204H and A106V altered the regiospecificity of nitrobenzene back to 27 % p-nitrophenol. TouA variants F269Y, F269P, Q204E, and L95D improved the meta-hydroxylating capability of nitrobenzene by producing 87, 85, 82, and 77 % m-nitrophenol, respectively. For naphthalene oxidation, TouA variants F269V, Q204A, Q204S/S222N, and F269T had the regiospecificity changed from 16 to 9, 10, 23, and 25 % 2-naphthol, respectively. Here, two additional TouA residues, S222 and A106, were also identified that may have important roles in catalysis. Most of the isolated variants from D211 remained active, whereas having a hydrophobic residue at this position appeared to diminish the catalytic activity toward naphthalene. The mutational effects on the ToMO regiospecificity described here suggest that it is possible to further fine tune and engineer the reactivity of multicomponent diiron monooxygenases toward different substrates at positions that are relatively distant from the active site. PMID:27311562

  16. Completion Report for Well ER-20-4 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Management

    2011-04-30

    Well ER-20-4 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site, Nye County, Nevada. The well was drilled in August and September 2010 as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to investigate the possibility of radionuclide transport from up-gradient underground nuclear tests conducted in central Pahute Mesa. This well also provided detailed hydrogeologic information in the Tertiary volcanic section that will help reduce uncertainties within the Pahute Mesa-Oasis Valley hydrostratigraphic framework model.

  17. Character of HBV (hepatitis B virus) polymerase gene rtM204V/I and rtL180M mutation in patients with lamivudine resistance

    Institute of Scientific and Technical Information of China (English)

    LI Min-wei; HOU Wei; WO Jian-er; LIU Ke-zhou

    2005-01-01

    Objectives: To investigate the relationship between HBV (hepatitis B virus) polymerase gene 180 and 204 sites mutation and lamivudine resistance. Methods: One hundred forty-one patients with lamivudine resistance after lamivudine treatment and 60 chronic hepatitis B patients without lamivudine treatment were enrolled in this study. The serum HBV DNA mutation was analyzed by sequence detection via polymerase chain reaction (PCR). The sequences of the same patient were analyzed before and after lamivudine treatment. Results: One hundred and nine lamivudine resistance patients had HBV YMDD (tyrosine-methionine-aspartate-aspartate) mutation. Among them, 45 patients had rtL 180M/M204V mutation (41.28%), 28patients had rtL180M/M204I mutation (25.70%) and 36 patients had rtM204I mutation (33.02%). There were 6 patients with rtL180M mutation in 32 lamivudine resistance patients. Sixty chronic hepatitis patients without lamivudine treatment had no mutations. Conclusions: HBV mutations, which play an important role in lamivudine resistance usually locate at polymerase gene 204 site; 180 site mutation was also observed in these patients. Evaluation of the anti-virus therapy by surveillance of the two sites mutations is of importance.

  18. 用盐酸及P204回收铅烟灰中铟的生产实践%Production Practice of Recovering Indium from Lead Reverberatory Dust with HCl Leaching -P204 Extraction

    Institute of Scientific and Technical Information of China (English)

    赵玉琴

    2013-01-01

    用盐酸浸取铅烟灰,铟的浸取率大于90%,浸取温度355 K ,浸取时间4 h ,再用P204萃取,用盐酸反萃,萃余液再用铅烟灰沉铟后送氯化锌车间。经一年多的生产实践,工艺技术可行,铟的回收率大于80%,铋的回收率大于90%。%Leaching the lead ash by hydrochloric acid , indium leaching rate is greater than 90% ,leaching temperature is 355 K , Leaching for 4 h , then extracting the lead ash by P204 , and back extracting it by hy-drochloric acid , extraction raffinate is sent to the zinc chloride workshop after precipitating indium . Pro-duction practicing more than one year show s that the technology is available , the recovery rate of indium is greater than 80% , bismuth recovery is more than 90% .

  19. Inhibition of smooth muscle contraction and platelet aggregation by peptide 204–212 of lipocortin 5: an attempt to define some structure requirements

    Directory of Open Access Journals (Sweden)

    K. G. Mugridge

    1993-01-01

    Full Text Available Peptide 204–212 of lipocortin (LC 5 inhibited porcine pancreatic phospholipase A2 (PLA2 induced rat stomach strip contractions and ADP induced rabbit platelet aggregation in a concentration dependent manner (IC30 of 10 μM and 400 μM, respectively. The first two amino acids are not necessary since the eptapeptide 206–212 was equipotent in both assays (IC30 of 12.5 μM and 420 μM. Of the two pentapeptides 204–208 and 208–212 only the latter showed inhibitory activity in both models although the potency was much reduced (IC30 of 170 μM and 630 μM compared with that of the parent nonapeptide. Comparison of peptide 204–212 effects with those of its analogues on LC1 and LC2 indicate that lysine 208 and aspartic acid 211 are essential in order to maintain a fully active nonapeptide.

  20. Attenuation of bremsstrahlung from 90Sr-90Y, 147Pm and 204Tl in thick target compounds

    Science.gov (United States)

    Manjunatha, H. C.

    2014-11-01

    The external bremsstrahlung (EB) produced by beta particles such as from 90Sr-90Y, 147Pm and 204Tl in PbCl2, PbF2, Pb(NO3)2 and CdO were measured using NaI(Tl) crystal. The beta stopper technique is employed to measure the integral intensities above 100 keV energy in different absorber thicknesses. Attenuation of the external bremsstrahlung, excited by 90Sr-90Y, 147Pm and 204Tl beta-emitters in the same compounds has also been studied. The measured attenuation parameter is not constant with absorber thickness and it increases with increasing Zmod of the absorber. Whereas, the mass attenuation coefficient of gamma rays of equivalent energy is independent of the absorber thickness. This confirms that the attenuation of EB in an absorber does not conform to a single exponential law, unlike the absorption of monoenergetic gamma rays. Rather it may be a combination of a large number of exponential terms.

  1. A humanized monoclonal antibody neutralizes yellow fever virus strain 17D-204 in vitro but does not protect a mouse model from disease.

    Science.gov (United States)

    Calvert, Amanda E; Dixon, Kandice L; Piper, Joseph; Bennett, Susan L; Thibodeaux, Brett A; Barrett, Alan D T; Roehrig, John T; Blair, Carol D

    2016-07-01

    The yellow fever virus (YFV) vaccine 17D-204 is considered safe and effective, yet rare severe adverse events (SAEs), some resulting in death, have been documented following vaccination. Individuals exhibiting post-vaccinal SAEs are ideal candidates for antiviral monoclonal antibody (MAb) therapy; the time until appearance of clinical signs post-exposure is usually short and patients are quickly hospitalized. We previously developed a murine-human chimeric monoclonal antibody (cMAb), 2C9-cIgG, reactive with both virulent YFV and 17D-204, and demonstrated its ability to prevent and treat YF disease in both AG129 mouse and hamster models of infection. To counteract possible selection of 17D-204 variants that escape neutralization by treatment with a single MAb (2C9-cIgG), we developed a second cMAb, 864-cIgG, for use in combination with 2C9-cIgG in post-vaccinal therapy. MAb 864-cIgG recognizes/neutralizes only YFV 17D-204 vaccine substrain and binds to domain III (DIII) of the viral envelope protein, which is different from the YFV type-specific binding site of 2C9-cIgG in DII. Although it neutralized 17D-204 in vitro, administration of 864-cIgG had no protective capacity in the interferon receptor-deficient AG129 mouse model of 17D-204 infection. The data presented here show that although DIII-specific 864-cIgG neutralizes virus infectivity in vitro, it does not have the ability to abrogate disease in vivo. Therefore, combination of 864-cIgG with 2C9-cIgG for treatment of YF vaccination SAEs does not appear to provide an improvement on 2C9-cIgG therapy alone.

  2. Transformer 2β and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA.

    Science.gov (United States)

    Kuwano, Y; Nishida, K; Kajita, K; Satake, Y; Akaike, Y; Fujita, K; Kano, S; Masuda, K; Rokutan, K

    2015-05-01

    RNA-binding proteins and microRNAs are potent post-transcriptional regulators of gene expression. Human transformer 2β (Tra2β) is a serine/arginine-rich-like protein splicing factor and is now implicated to have wide-ranging roles in gene expression as an RNA-binding protein. RNA immunoprecipitation (RIP) with an anti-Tra2β antibody and microarray analysis identified a subset of Tra2β-associated mRNAs in HCT116 human colon cancer cells, many of which encoded cell death-related proteins including Bcl-2 (B-cell CLL/lymphoma 2). Tra2β knockdown in HCT116 cells decreased Bcl-2 expression and induced apoptosis. Tra2β knockdown accelerated the decay of BCL2α mRNA that encodes Bcl-2 and full-length 3' UTR, while it did not affect the stability of BCL2β mRNA having a short, alternatively spliced 3' UTR different from BCL2α 3' UTR. RIP assays with anti-Tra2β and anti-Argonaute 2 antibodies, respectively, showed that Tra2β bound to BCL2α 3' UTR, and that Tra2β knockdown facilitated association of miR-204 with BCL2α 3' UTR. The consensus sequence (GAA) for Tra2β-binding lies within the miR-204-binding site of BCL2 3' UTR. Mutation of the consensus sequence canceled the binding of Tra2β to BCL2 3' UTR without disrupting miR-204-binding to BCL2 3' UTR. Transfection of an anti-miR-204 or introduction of three-point mutations into the miR-204-binding site increased BCL2 mRNA and Bcl-2 protein levels. Inversely, transfection of precursor miR-204 reduced their levels. Experiments with Tra2β-silenced or overexpressed cells revealed that Tra2β antagonized the effects of miR-204 and upregulated Bcl-2 expression. Furthermore, TRA2β mRNA expression was significantly upregulated in 22 colon cancer tissues compared with paired normal tissues and positively correlated with BCL2 mRNA expression. Tra2β knockdown in human lung adenocarcinoma cells (A549) increased their sensitivity to anticancer drugs. Taken together, our findings suggest that Tra2β regulates apoptosis by

  3. The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death.

    Science.gov (United States)

    Chen, Peng-Hsu; Chang, Cheng-Kuei; Shih, Chwen-Ming; Cheng, Chia-Hsiung; Lin, Cheng-Wei; Lee, Chin-Cheng; Liu, Ann-Jeng; Ho, Kuo-Hao; Chen, Ku-Chung

    2016-11-01

    Xanthohumol (XN), a prenylated chalcone extracted from hop plant Humulus lupulus L. (Cannabaceae), has potential for cancer therapy, including gliomas. Micro (mi)RNAs are small noncoding RNAs that control gene expression. Several miRNAs have been identified to participate in regulating glioma development. However, no studies have demonstrated whether miRNA is involved in XN cytotoxicity resulting in glioma cell death. This study investigated the effects of XN-mediated miRNA expression in activating apoptotic pathways in glioblastoma U87 MG cells. First, we found that XN significantly reduced cell viability and induced apoptosis via pro-caspase-3/8 cleavage and poly(ADP ribose) polymerase (PARP) degradation. We also identified that pro-caspase-9 cleavage, Bcl2 family expression changes, mitochondrial dysfunction, and intracellular ROS generation also participated in XN-induced glioma cell death. With a microarray analysis, miR-204-3p was identified as the most upregulated miRNA induced by XN cytotoxicity. The extracellular signal-regulated kinase (ERK)/c-Fos pathway was validated to participate in XN-upregulated miR-204-3p expression. With a promoter assay and ChIP analysis, we found that c-Fos dose-dependently bound to the miR-204-3p gene promoter region. Furthermore, miR-204-3p levels decreased in several glioma cell lines compared to astrocytes. Overexpression of miR-204-3p enhanced glioma cell apoptosis. IGFBP2, an upregulated regulator of glioma proliferation, was validated by a TCGA analysis as a direct target gene of miR-204-3p. XN's inhibition of the IGFBP2/AKT/Bcl2 pathway via miR-204-3p targeting played a critical role in mediating glioma cell death. These results emphasized that the XN-mediated miR-204-3p network may provide novel therapeutic strategies for future glioblastoma therapy and drug development.

  4. Ureteroscope pneumatic lithotripsy for 204 cases of ureteral calculi%输尿管镜气压弹道碎石术治疗输尿管结石204例效果观察及治疗策略

    Institute of Scientific and Technical Information of China (English)

    张力; 胡兴平; 王凯

    2012-01-01

    Objective To investigate the effect of ureteroscope pneumatic lithotripsy for ureteral calculi. Methods Pneumatic lithotripsy under ureteroscopy was used to treat 204 cases of ureteral calculi, including 16 cases (8% ) in middle ureter and 188 cases (92% ) in lower ureter, in which 6 cases were in the wall of urinary bladder. Results The operation time varied from 15 to 116 min (45 min on average). The success rate of ureteroscope pneumatic lithotripsy was 98.0% (200 cases). The intraoperative stone free rate was 96. 6%. Stones in 2 cases transferred to kidney. Thus the surgery ended in failure. Some stones in 3 cases transferred to kidney after ureteroscope pneumatic lithotripsy (diameterIS3 mm). Stones in 1 case were exceptionally hard which could not be shattered by pneumatic lithotripsy probe and transferred to surgery. In another case, due to severe local mucosal edema with hemorrhage caused by swelling in the opening of the wall of urinary bladder, we could not find the front opening of ureter and insert a guide wire into it. This case was then cured by both surgery and ureteroscope pneumatic lithotripsy. Postoperative hematuria was observed by naked eye or microscope in all the cases, and disappeared 2-3 days after operation. No complications such as perforation and infection were found in any cases. Conclusions Ureteroscope pneumatic lithotripsy for ureteral calculi is effective, safe, with small damage of tissue, fewer complications, which can be used as the top choice for ureteral calculi in middle and lower ureter.%目的 观察输尿管镜气压弹道碎石术治疗输尿管结石的效果.方法 应用输尿管镜下气压弹道碎石治疗输尿管结石204例,其中输尿管中段结石16例(占8%),输尿管下段结石188例(占92%),膀胱壁内段结石6例.结果 204例手术时间15 ~116分钟,平均45分钟;碎石成功率98.0%(200例),术中结石排净率96.6%,2例结石漂移至肾脏,未能完成手术;3例碎石后,

  5. 41 CFR 302-3.204 - When an employed immediate family member and I are transferring in the interest of the Government...

    Science.gov (United States)

    2010-07-01

    ... immediate family member and I are transferring in the interest of the Government, what information must we... Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types of Transfers Relocation of Two Or More Employed Immediate Family Members § 302-3.204 When an...

  6. Fabry-perot kinematics of hh 202-204 in the orion nebula: are they part of a big bipolar outflow?

    Directory of Open Access Journals (Sweden)

    M. Rosado

    2002-01-01

    Full Text Available Se presenta un estudio cinem atico de los objetos HH 202, 203 y 204 usando mapas de velocidad Fabry-Perot en H y [N II]. En el caso de HH 202 se encuentran nebulosidades que podr an estar asociadas a este objeto o bien, dada sus altas velocidades (superiores a 100 km s

  7. How to Use the ADI-R for Classifying Autism Spectrum Disorders? Psychometric Properties of Criteria from the Literature in 1,204 Dutch Children

    Science.gov (United States)

    de Bildt, Annelies; Oosterling, Iris J.; van Lang, Natasja D. J.; Kuijper, Sanne; Dekker, Vera; Sytema, Sjoerd; Oerlemans, Anoek M.; van Steijn, Daphne J.; Visser, Janne C.; Rommelse, Nanda N.; Minderaa, Ruud B.; van Engeland, Herman; van der Gaag, Rutger-Jan; Buitelaar, Jan K.; de Jonge, Maretha V.

    2013-01-01

    The algorithm of the Autism Diagnostic Interview-Revised provides criteria for autism versus non-autism according to DSM-IV. Criteria for the broader autism spectrum disorders are needed. This study investigated the validity of seven sets of criteria from the literature, in 1,204 Dutch children (aged 3-18 years) with and without mental…

  8. Coupled-channel analysis for 20.4 MeV energy of p-^{64}Zn inelastic scattering

    Indian Academy of Sciences (India)

    Harun Yücel; Müşfik Taşan

    2012-02-01

    In this study, a coupled-channel (CC) analysis of the elastic and the inelastic scattering of 20.4 MeV polarized protons from a 64Zn target leading to the deformed 2+, $3^−$, $2^+_2$ states was performed. The CC potential parameters and the deformation parameters of the excited states corresponding to the best fit to the experimental differential cross-sections and the analysing powers data were determined. For $2^+_2$ excited state, a mixed type was used and a good fit to the data was provided. The CC calculation results were compared to the pure distorted wave Born approximation (DWBA) calculation results which were calculated using the new parameters. All calculations were conducted using the computer code ECIS06.

  9. Corrective Action Decision Document for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada, Revision 0 with ROTC 1, 2, and Errata

    Energy Technology Data Exchange (ETDEWEB)

    Wickline, Alfred

    2004-04-01

    This Corrective Action Decision Document (CADD) has been prepared for Corrective Action Unit (CAU) 204 Storage Bunkers, Nevada Test Site (NTS), Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (FFACO) that was agreed to by the State of Nevada; U.S. Department of Energy (DOE); and the U.S. Department of Defense (FFACO, 1996). The NTS is approximately 65 miles (mi) north of Las Vegas, Nevada (Figure 1-1). The Corrective Action Sites (CASs) within CAU 204 are located in Areas 1, 2, 3, and 5 of the NTS, in Nye County, Nevada (Figure 1-2). Corrective Action Unit 204 is comprised of the six CASs identified in Table 1-1. As shown in Table 1-1, the FFACO describes four of these CASs as bunkers one as chemical exchange storage and one as a blockhouse. Subsequent investigations have identified four of these structures as instrumentation bunkers (CASs 01-34-01, 02-34-01, 03-34-01, 05-33-01), one as an explosives storage bunker (CAS 05-99-02), and one as both (CAS 05-18-02). The six bunkers included in CAU 204 were primarily used to monitor atmospheric testing or store munitions. The ''Corrective Action Investigation Plan (CAIP) for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada'' (NNSA/NV, 2002a) provides information relating to the history, planning, and scope of the investigation; therefore, it will not be repeated in this CADD. This CADD identifies potential corrective action alternatives and provides a rationale for the selection of a recommended corrective action alternative for each CAS within CAU 204. The evaluation of corrective action alternatives is based on process knowledge and the results of investigative activities conducted in accordance with the CAIP (NNSA/NV, 2002a) that was approved prior to the start of the Corrective Action Investigation (CAI). Record of Technical Change (ROTC) No. 1 to the CAIP (approval pending) documents changes to the preliminary action levels

  10. Cu0.02Ti0.94Nb2.04O7: An advanced anode material for lithium-ion batteries of electric vehicles

    Science.gov (United States)

    Yang, Chao; Lin, Chunfu; Lin, Shiwei; Chen, Yongjun; Li, Jianbao

    2016-10-01

    To explore advanced anode materials for lithium-ion batteries of electric vehicles, Cu2+/Nb5+ co-doped TiNb2O7 is studied. Cu0.02Ti0.94Nb2.04O7 is successfully fabricated using a facile solid-state reaction. X-ray diffraction analyses combined with Rietveld refinements demonstrate that the trace Cu2+/Nb5+ co-doping does not destroy the shear ReO3 crystal structure of TiNb2O7 but increases the lattice parameters and unit cell volume. Specific surface area tests and scanning electron microscopy images reveal a smaller average particle size in Cu0.02Ti0.94Nb2.04O7. Due to the increased unit cell volume and free 3d electrons in Cu2+ ions, the Li+-ion diffusion coefficient and electronic conductivity of Cu0.02Ti0.94Nb2.04O7 are respectively enhanced by 14.8 times and at least 220 times. Consequently, Cu0.02Ti0.94Nb2.04O7 exhibits advanced electrochemical properties in terms of specific capacity, rate capability and cyclic stability. At 0.1 C, it delivers a large first-cycle discharge/charge capacity of 346/315 mAh g-1. At 10 C, it still provides a large capacity of 182 mAh g-1 with tiny loss of only 1.2% over 1000 cycles. In sharp contrast, TiNb2O7 shows a small capacity of only 90 mAh g-1 and large loss of 59.8%. Therefore, Cu0.02Ti0.94Nb2.04O7 possesses great potential for the application in lithium-ion batteries for electric vehicles.

  11. Tank Vapor Characterization Project: Headspace vapor characterization of Hanford Waste Tank U-204, Results from samples collected on August 8, 1995

    International Nuclear Information System (INIS)

    This report describes the analytical results of vapor samples taken from the headspace of the waste storage tank 241-U-204 (Tank U-204) at the Hanford Site in Washington State. The results described in this report were obtained to characterize the vapors present in the tank headspace and to support safety evaluations and tank-farm operations. The results include air concentrations of selected inorganic and organic analytes and grouped compounds from samples obtained by Westinghouse Hanford Company (WHC) and provided for analysis to Pacific Northwest National Laboratory (PNL). Analyses were performed by the Vapor Analytical Laboratory (VAL) at PNL. Analyte concentrations were based on analytical results and, where appropriate, sample volumes provided by WHC. A summary of the results is listed. Detailed descriptions of the analytical results appear in the text

  12. Book review: Dominique Brossard, James Shanahan and Clint Nesbitt (eds), The Public, the Media and Agricultural Biotechnology (Wallingford: CABI, 2007). 414pp. ISBN 978 1 84593 204 6, #75.00 / $150.00

    OpenAIRE

    2008-01-01

    Book review: Dominique Brossard, James Shanahan and Clint Nesbitt (eds), The Public, the Media and Agricultural Biotechnology (Wallingford: CABI, 2007). 414pp. ISBN 978 1 84593 204 6, #75.00 / $150.00

  13. Food sources of total omega 6 fatty acids (18:2 + 20:4), listed in descending order by percentages of their contribution to intake, based on data from the National Health and Nutrition Examination Survey 2005-2006

    Science.gov (United States)

    Food sources of total omega 6 fatty acids (18:2 + 20:4), listed in descending order by percentages of their contribution to intake, based on data from the National Health and Nutrition Examination Survey 2005-2006

  14. Food sources of arachidonic acid (PFA 20:4), listed in descending order by percentages of their contribution to intake, based on data from the National Health and Nutrition Examination Survey 2005-2006

    Science.gov (United States)

    Food sources of arachidonic acid (PFA 20:4), listed in descending order by percentages of their contribution to intake, based on data from the National Health and Nutrition Examination Survey 2005-2006

  15. Safety and efficacy of rhBMP2 in posterior cervical spinal fusion for subaxial degenerative spine disease: Analysis of outcomes in 204 patients

    OpenAIRE

    Xu, Risheng; Bydon, Mohamad; Sciubba, Daniel M.; Witham, Timothy F.; Wolinsky, Jean-Paul; Gokaslan, Ziya L; Bydon, Ali

    2011-01-01

    Background: Many studies offer excellent demonstration of the ability of bone morphogenic protein (BMP) to enhance fusion rates in anterior as well as posterior lumbar surgery. Recently, BMP has also been shown to increase arthrodesis rates in anterior cervical surgery, albeit with concomitant increases in complication rates. To date, however, few studies have investigated the safety and efficacy of BMP in cervical surgeries approached posteriorly. Methods: We retrospectively reviewed 204 con...

  16. Modeling and Docking Studies on Novel Mutants (K71L and T204V of the ATPase Domain of Human Heat Shock 70 kDa Protein 1

    Directory of Open Access Journals (Sweden)

    Asita Elengoe

    2014-04-01

    Full Text Available The purpose of exploring protein interactions between human adenovirus and heat shock protein 70 is to exploit a potentially synergistic interaction to enhance anti-tumoral efficacy and decrease toxicity in cancer treatment. However, the protein interaction of Hsp70 with E1A32 kDa of human adenovirus serotype 5 remains to be elucidated. In this study, two residues of ATPase domain of human heat shock 70 kDa protein 1 (PDB: 1 HJO were mutated. 3D mutant models (K71L and T204V using PyMol software were then constructed. The structures were evaluated by PROCHECK, ProQ, ERRAT, Verify 3D and ProSA modules. All evidence suggests that all protein models are acceptable and of good quality. The E1A32 kDa motif was retrieved from UniProt (P03255, as well as subjected to docking interaction with NBD, K71L and T204V, using the Autodock 4.2 program. The best lowest binding energy value of −9.09 kcal/mol was selected for novel T204V. Moreover, the protein-ligand complex structures were validated by RMSD, RMSF, hydrogen bonds and salt bridge analysis. This revealed that the T204V-E1A32 kDa motif complex was the most stable among all three complex structures. This study provides information about the interaction between Hsp70 and the E1A32 kDa motif, which emphasizes future perspectives to design rational drugs and vaccines in cancer therapy.

  17. FOXC1 in human trabecular meshwork cells is involved in regulatory pathway that includes miR-204, MEIS2, and ITGβ1.

    Science.gov (United States)

    Paylakhi, Seyed Hassan; Moazzeni, Hamidreza; Yazdani, Shahin; Rassouli, Paniz; Arefian, Ehsan; Jaberi, Elham; Arash, Emad Heidari; Gilani, Ahmad Sadighi; Fan, Jian-Bing; April, Craig; Amin, Sadaf; Suri, Fatemeh; Elahi, Elahe

    2013-06-01

    Forkhead box C1 (FOXC1) is a transcription factor that affects eye development. FOXC1 is implicated in the etiology of glaucoma because mutations in the gene are among the causes of Axenfeld-Rieger syndrome which is often accompanied by glaucoma. Glaucoma is the second leading cause of blindness. It is a complex disorder whose genetic basis in most patients remains unknown. Microarrays expression analysis was performed to identify genes in human trabecular meshwork (TM) primary cultures that are affected by FOXC1 and genes that may have roles in glaucoma. This represents the first genome wide analysis of FOXC1 target genes in any tissue. FOXC1 knock down by siRNAs affected the expression of 849 genes. Results on selected genes were confirmed by real time PCR, immunoblotting, and dual luciferase reporter assays. Observation of MEIS2 as a FOXC1 target and consideration of FOXC1 as a potential target of miR-204 prompted testing the effect of this micro RNA on expression of FOXC1 and several genes identified by array analysis as FOXC1 target genes. It was observed that miR-204 caused decreased expression of FOXC1 and the FOXC1 target genes CLOCK, PLEKHG5, ITGβ1, and MEIS2 in the TM cultures. Expression of CLOCK, PLEKHG5, ITGβ1 has not previously been reported to be affected by miR-204. The data suggest existence of a complex regulatory pathway in the TM part of which includes interactions between FOXC1, miR-204, MEIS2, and ITGβ1. All these molecules are known to have TM relevant functions, and the TM is strongly implicated in the etiology of glaucoma. PMID:23541832

  18. Identification of glutamic acid 204 and aspartic acid 200 in chitinase A1 of Bacillus circulans WL-12 as essential residues for chitinase activity.

    Science.gov (United States)

    Watanabe, T; Kobori, K; Miyashita, K; Fujii, T; Sakai, H; Uchida, M; Tanaka, H

    1993-09-01

    Prokaryotic chitinases, class III plant chitinases, yeast chitinases, and endo-beta-N-acetylglucosaminidases share weak amino acid sequence similarities at the certain region of each enzyme. These regions have been assumed to be important for catalytic activities of the enzymes. To verify this assumption, three amino acid residues (Ser-160, Asp-200, Glu-204) in chitinase A1 of Bacillus circulans WL-12 were chosen, based on the amino acid sequence alignment of the regions sharing sequence similarity, and were replaced by site-directed mutagenesis. Kinetic parameters for 4-methylumbelliferyl-N,N',N"-triacetylchitotriose hydrolysis were determined with wild-type and seven mutant chitinases. Chitinases with Glu-204-->Gln mutation and Glu-204-->Asp mutation were essentially inactive and kcat values of these chitinases were approximately 1/5,000 and 1/17,000 of that of wild-type chitinase, respectively. Asp-200-->Asn mutation decreased the kcat value to approximately 1/350 of that of the wild-type enzyme, while the Km value decreased only slightly. On the other hand, neither the kcat value nor the Km value was affected by Asp-200-->Glu mutation. Thus, it appeared that Glu-204 and Asp-200 are directly involved in the catalytic events of chitinase A1. The role of the carboxyl group of Asp-200 can be fully substituted by that of Glu residue. The Ser-160-->Ala mutant retained 10% activity of the wild-type chitinase indicating that the hydroxyl group of Ser-160 is not absolutely required for the catalytic activity. These results indicate a lysozyme-type catalytic mechanism of the chitinase.

  19. Global requirements for DNA sample collections: results of a survey of 204 ethics committees in 40 countries.

    Science.gov (United States)

    Ricci, D S; Broderick, E D; Tchelet, A; Hong, F; Mayevsky, S; Mohr, D M; Schaffer, M E; Warner, A W; Hakkulinen, P; Snapir, A

    2011-04-01

    The Industry Pharmacogenomics Working Group has an interest in attaining a better understanding of global requirements for sample collections intended for pharmacogenetics research. To have adequately powered pharmacogenetics studies representative of the clinical trial population, it is important to collect DNA samples from a majority of consenting study participants under many institutional review board/ethics committee (IRB/EC) jurisdictions. A survey was distributed to gather information from local and central IRBs/ECs. The survey included questions related to the approval of pharmacogenetics studies, collection and banking of samples, and return of data to subjects. A total of 204 responses were received from global IRBs/ECs with pharmacogenetic experience. The data show that requirements for approval of pharmacogenetic research differ between IRBs/ECs within and between countries but not between regions of the United States. A better understanding of differing requirements should facilitate global sample collection of DNA for pharmacogenetics research and may provide the basis for harmonized regulations for collection of genetic samples in the future. PMID:21346753

  20. Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients.

    Science.gov (United States)

    Yalcinkaya, Ulviye; Doganavsargil, Basak; Sezak, Murat; Kececi, Burcin; Argin, Mehmet; Basdemir, Gulcin; Oztop, Fikri

    2014-12-01

    Osteoid osteoma and osteoblastoma are histologically similar, benign bone-forming tumors. In this retrospective study, we aimed to evaluate the natural history; clinical, pathologic, and radiologic findings; and treatment results in 204 patients between 1959 and 2006 in a single institution. According to the World Health Organization's definition, tumors ≤1 cm in diameter were classified as osteoid osteoma, and those ≥2 cm, as osteoblastoma. For tumors between 1 cm and 2 cm, other criteria, such as the bone involved, the site, the presence of a nidus, and presence of peripheral sclerosis, were used for diagnosis. There were 131 patients with osteoid osteoma (93 male, 38 female) and 73 patients with osteoblastoma (40 male, 33 female). The mean age in the osteoid osteoma and osteoblastoma groups was 16.4 ± 7 and 19.6 ± 9.9 years, respectively. The osteoid osteoma cases were mostly localized in the extremities, whereas the osteoblastoma cases involved the vertebral column and sacrum. The nidus size varied between 0.2 and 1.5 cm in osteoid osteoma cases, and the tumor size range was 1.3-10 cm in the osteoblastoma cases. The pain was encountered in 89% of osteoid osteoma and 45% of osteoblastoma patients. Histopathology was similar in both cases. The treatment of choice was conservative surgery for both diagnoses. In conclusion, osteoblastoma is clinically and radiologically more aggressive than osteoid osteoma.

  1. 204例孕妇营养知识水平、态度与行为调查%Investigation on nutritional knowledge level, attitude and practice of 204 pregnant women

    Institute of Scientific and Technical Information of China (English)

    闻立芳; 曾亮华; 李秀琼; 秦子惠; 牛晓虎

    2011-01-01

    目的:了解深圳市孕妇营养知识、饮食行为及其影响因素,为开展孕妇营养教育工作提供依据.方法:采用随机抽样方法对204例孕妇进行营养知识、态度、行为问卷调查.结果:孕妇营养KAP水平较差,总合格率为75.5%;30.4%的孕妇营养知识不足,营养态度不端正占26.5%.营养行为三者普遍较好,合格率达83.3%;孕妇的营养知识、态度、行为三者呈明显正相关关系;孕妇获得营养信息的来源主要是网络(88.6%)和专业书籍(69.3%)、报刊杂志和电视广播各占50.0%.教育程度和孕周、年龄、户籍、职业对孕妇营养KAP水平有影响(P<0.000 1).结论:加强医院孕期营养教育,对孕妇开展有针对性的个体化营养教育和干预,提高医务人员的营养知识技能水平,同时应全面提高孕产妇健康素质.%Objective: To understand the nutritional knowledge and dietary behavior of pregnant women in Shenzhen and the effect factors, provide a basis for carrying out nutritional educational work among pregnant women. Methods: Random sampling method was used to survey nutritional knowledge, attitude and practice (KAP) of 204 pregnant women. Results: The nutritional KAP level of pregnant women in Shenzhen was low, the total passing rate was 75. 5% , 30. 4% of the pregnant women lacked nutritional knowledge, the proportion of pregnant women with incorrect nutritional attitude was 26. 5%. The nutritional behavior of pregnant women in Shenzhen was good, the passing rate was 83. 3% ; there was a correlation among nutritional KAP. The sources of nutritional information were from the network (88. 6% ) and books (69. 3% ); newspaper/magazine and TV/radio accounted for 50.0% , respectively. The educational level, gestational weeks, maternal age, household register and occupation had impact on nutritional KAP level of pregnant women in Shenzhen (P < 0. 000 1) . Conclusion : The nutritional education during pregnancy should be

  2. NEW METHOD FOR DETERMINING HEPATITIS B VIRUS RESISTANCE MUTATIONS M204I/V TO NUCLEOS(TIDE ANALOGUES IN PATIENTS WITH CHRONIC HEPATITIS B

    Directory of Open Access Journals (Sweden)

    E. A. Elpaeva

    2015-01-01

    Full Text Available Аnalogues of nucleos(tides (AN such as lamivudine (LAM, telbivudine (TBV, adefovir (ADP, entecavir (ENT are widely used for the treatment of chronic hepatitis B (CHB. However, the prolonged treatment using these drugs often leads to the development of drug resistance. The most common substitutions in the reverse transcriptase are methionine for valine (rtM204V, or methionine for isoleucine (rtM204I at position 204. Early AN-resistant mutations detection is of great importance to determine the treatment strategy of patients with CHB. Currently there are many highly sensitive methods for detection of drug resistance mutations, such as next-generation sequencing, reverse hybridizationbased line probe assay (LiPA, mass spectrometry. However, these methods require expensive equipment and reagents, and they are not widely used in clinical laboratories. The aim of this study was to develop a simple and accurate real-time PCR method for detection of rtM204I/V mutation. This method showed high specificity and sensitivity (1000 copies/ml, it is less laborious and does not require additional equipment, fast and cost effective compared to other methods. HBV mutations of resistance to AN were determined in 5 groups of patients with CHB. Patients of the first group received monotherapy with pegylated interferon (n = 12, the second group — lamivudine (n = 10, the third group — telbivudine (n = 7, the fourth group — entecavir (n = 15. The fifth group consisted of patients who did not receive antiviral therapy (n = 3. The frequency of mutations in HBV polymerase YMDD-motif was determined among 47 patients with CHB: it was 10% for lamivudine treated patients, 20% — for entecavir, 28% — for telbivudine. YIDD/YVDD motifs were identified in two patients and YMDD/YIDD — in one patient. Real-time PCR method for the detection of AN-resistant rtM204I/V mutations in HBV polymerase can be used in routine diagnostics for primary screening of patients not

  3. 经皮球囊肺动脉瓣成形术204例临床分析%Clinical analysis in 204 cases with percutaneous balloon pulmonary valvoplasty

    Institute of Scientific and Technical Information of China (English)

    王霄芳; 金梅; 吴邦骏; 郑可; 郭保静; 梁永梅; 肖燕燕; 李伟; 韩玲

    2011-01-01

    目的:探讨经皮球囊肺动脉瓣成形术(PBPV),治疗肺动脉瓣狭窄(PS)及室间隔完整的肺动脉瓣闭锁(PA/IVS)的安全性及有效性.方法:我科自1987年4月至2011年5月收治的PS202例,PA/IVS 2例,男性116例,女性88例,年龄3个月~40岁,平均4.25岁,体质量5~60 kg,平均(17.32±8 85)kg,发绀34例.完善心电图、心脏X线像、超声心动图检查,行右心导管检查及右心室造影并完成PBPV.结果:PBPV 204例,成功200例,成功率98%.PBPV术后,导管测肺动脉瓣跨瓣压差[(30 84±15.05 )mmHg(1 mmHg=0.133 kPa)]较术前(75.75±30.04)mmHg明显下降,P=0.001.4例失败病例中,1例因右心室流出道狭窄导丝难以到达肺动脉,取消PBPV.第2例导丝送入肺动脉出现循环不稳定取消PBPV.第3例PA/IVS,射频打孔成功后球囊扩张时出现心包填塞,转外科手术.第4例术中球囊扩张时右心室流出道撕裂致心包填塞,抢救无效死亡.其中2例出现严重并发症,1例三尖瓣腱索断裂;1例缺血、缺氧性脑病.结论:PBPV治疗PS及PA/IVS安全有效.严格掌握适应证,规范操作可以减少并发症.%Objective; To investigate the safety and effectiveness of percutaneous balloon pulmonary valvuloplasty (PBPV) in the treatment of pulmonary valve stenosis (PS) and pulmonary atresia with intact ventricular septum (PA/IVS). Methods; From April 1987 to May 2011 , 202 patients with PS and two with PA / IVS [male 116, female 88; aged 3 months to 40 years, mean (4. 25 ± 4. 16) years; body weight (5 -60) kg, average (17. 32 ± 8. 85) kg; 34 cases with cyanosis] were treated in the Department of Pediatric Cardiology , Beijing AnZhen Hospital. All patients were also assessed with electrocardiogram(ECG) , X-ray chest radiography , echocardiography, right heart catheterization and right ventricular angiography before the procedure. It is important to emphasize the need to measure the pulmonary valve annulus at the hinge point. PBPV were performed in 204 patients

  4. Death from Liver Failure despite Lamivudine Prophylaxis during R-CHOP Chemotherapy due to Rapid Emergence M204 Mutations

    Directory of Open Access Journals (Sweden)

    Lay Lay Win

    2013-01-01

    Full Text Available Background. Rapid and early emergence of clinically significant LAM resistance is thought to be unlikely during the first year of treatment, and as a result LAM is thought to be a reasonable choice as a first line agent for prophylaxis during chemotherapy. Aim. To report fatal HBV reactivation despite appropriate LAM prophylaxis in two previously treatment-naive individuals undergoing R-CHOP chemotherapy. Case Presentation. Case 1 is a 65-year-old man with chronic HBV infection: HBeAg-negative, HBV DNA 6.65E5 IU/mL, ALT 43 IU/L, and Fibroscan 4.4 kPa, consistent with F0, who was diagnosed with lymphoma that was treated with R-CHOP and LAM prophylaxis. HBV DNA fell to 2.18E1 IU/mL within 2 months of starting LAM. Four months after chemotherapy, despite ongoing LAM of 7-month duration with confirmed adherence, severe asymptomatic hepatitis was noted during routine monitoring with ALT 1019 IU/L, HBeAg negative, HBV DNA 1.43E7 IU/mL, and genotyping confirmed L80I and M204I mutations. He died 14 days after flare diagnosis despite a switch to tenofovir (HBV DNA had fallen to 1.94E5 IU/mL 2 weeks after starting tenofovir. Case 2 is a 50-year-old man who was found to have HBeAg-negative hepatitis B, ALT 37 IU/L, and no clinical features of cirrhosis (platelets 283, APRI 0.19 after lymphoma diagnosis. Lymphoma was treated with R-CHOP and LAM prophylaxis. Pretreatment HBV DNA was not done but was 8.90E4 IU/mL 3 weeks after starting LAM and 3.96E3 IU/mL 3 months after starting LAM. Two months after chemotherapy, despite ongoing LAM of 7-month duration with confirmed adherence, severe symptomatic hepatitis presenting with jaundice, abdominal pain, and confusion was noted. ALT 902 IU/L, HBeAg negative, HBV DNA 1.02E8 IU/mL, and genotyping confirmed L80I, M80V, and M204V/S mutations. He died 3 days after flare diagnosis despite the addition of tenofovir. Conclusion. Lamivudine should not be used for prophylaxis of patients with chronic

  5. AMO-miR-204 antisense oligonucleotides enhance the sensitivity of MOLT-4 cells to matrine%Hsa-miR-204反义核酸提高MOLT-4细胞对苦参碱的敏感性研究

    Institute of Scientific and Technical Information of China (English)

    孙文洪; 何金花; 韩泽平; 黄国贤; 朱丽梨; 何琨仪; 陈炳豪

    2014-01-01

    目的 研究miR-204的反义核酸(anti-miR204 oligonucleotides,AMO-miR-204)联合苦参碱观察其对人急性淋巴细胞白血病细胞株(MOLT-4)生长与凋亡的影响及机制.方法 将一定浓度的人工合成的AMO-miR-204经脂质体包裹转染MOLT-4细胞,并联合不同浓度的苦参碱作用于MOLT-4细胞48 h后,采用MTT法检测单用AMO-miR-204、单用苦参碱及AMO-miR-204联合苦参碱对MOLT-4细胞增殖抑制作用,流式细胞术检测细胞早期凋亡率;实时荧光定量RT-PCR检测细胞 Bcl-2mRNA 的表达水平;克隆形成抑制实验检测克隆形成能力.结果单用苦参碱的IC50为0.75 mg·L-1;苦参碱与阴性对照联合使用,IC50为0.29 mg·L-1,表现为相加作用;苦参碱与AMO- miR-204联合使用,IC50为0.07 mg·L-1,增敏倍数为10.7,表现为协同作用.流式细胞术结果显示:联合组比单用组早期凋亡率明显增高,凋亡率达25.4%.单用AMO-miR-204、苦参碱及两者联均能下调 Bcl-2mRNA基因的表达水平,对MOLT-4细胞克隆形成逐渐减小,其中两者联合的克隆数为(28±3.0).结论 AMO- miR-204可提高MOLT-4细胞对苦参碱的敏感性,其机制可能为通过下调Bcl-2 mRNA的表达水平,促进MOLT-4细胞早期凋亡,并抑制其克隆形成有关.

  6. Corrective Action Investigation Plan for Corrective Action Unit 204: Storage Bunkers, Nevada Test Site, Nevada (December 2002, Revision No.: 0), Including Record of Technical Change No. 1

    Energy Technology Data Exchange (ETDEWEB)

    NNSA/NSO

    2002-12-12

    The Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 204 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 204 is located on the Nevada Test Site approximately 65 miles northwest of Las Vegas, Nevada. This CAU is comprised of six Corrective Action Sites (CASs) which include: 01-34-01, Underground Instrument House Bunker; 02-34-01, Instrument Bunker; 03-34-01, Underground Bunker; 05-18-02, Chemical Explosives Storage; 05-33-01, Kay Blockhouse; 05-99-02, Explosive Storage Bunker. Based on site history, process knowledge, and previous field efforts, contaminants of potential concern for Corrective Action Unit 204 collectively include radionuclides, beryllium, high explosives, lead, polychlorinated biphenyls, total petroleum hydrocarbons, silver, warfarin, and zinc phosphide. The primary question for the investigation is: ''Are existing data sufficient to evaluate appropriate corrective actions?'' To address this question, resolution of two decision statements is required. Decision I is to ''Define the nature of contamination'' by identifying any contamination above preliminary action levels (PALs); Decision II is to ''Determine the extent of contamination identified above PALs. If PALs are not exceeded, the investigation is completed. If PALs are exceeded, then Decision II must be resolved. In addition, data will be obtained to support waste management decisions. Field activities will include radiological land area surveys, geophysical surveys to identify any subsurface metallic and nonmetallic debris, field screening for applicable contaminants of potential concern, collection and analysis of surface and subsurface soil samples from biased locations

  7. (112) and (220)/(204)-oriented CuInSe{sub 2} thin films grown by co-evaporation under vacuum

    Energy Technology Data Exchange (ETDEWEB)

    Ruffenach, Sandra; Robin, Yoann; Moret, Matthieu, E-mail: matthieu.moret@univ-montp2.fr; Aulombard, Roger-Louis; Briot, Olivier

    2013-05-01

    CuInSe{sub 2} (CIS) layers were grown by co-evaporation in a molecular beam epitaxy system onto soda lime glass substrates by using both two-step and three step processes. The physical properties of the layers were investigated using X-ray diffraction (XRD) and optical spectroscopy. The sample atomic composition was assessed by energy dispersive analysis of X-rays. Cu-rich or In-rich CIS thin films were obtained exhibiting strong preferential (112) and (220)/(204) orientations in both cases. We performed thermal annealing at 450 °C under nitrogen, keeping Se overpressure to avoid Se desorption from the layer. The annealed layers all exhibit improved crystalline quality, with reduced stoichiometric discrepancy. The secondary phases like Cu{sub x}Se{sub 1−x} or In{sub x}Se{sub 1−x} are no more observable by XRD measurements. Regarding the preferential orientation, thermal annealing of Cu-rich CIS layers favours the (112) orientation leading to a more (112) textured layer after annealing, whatever the initial preferential growth orientation was. In opposite, thermal annealing of In-rich samples increases the (220)/(204) texture of the sample. - Highlights: ► We have studied the thermal annealing effect of Cu-rich and In-rich CuInSe{sub 2}. ► Thermal annealing improves the optical and crystalline quality. ► Secondary phase turned to CuInSe{sub 2} through a recrystallization process or evaporated. ► Thermal annealing of Cu-rich layers leads to an increase of the (112) texture. ► Thermal annealing of In-rich layers leads to an increase of the (220)/(204) texture.

  8. The two mutations, Q204X and nt821, of the myostatin gene affect carcass and meat quality in young heterozygous bulls of French beef breeds

    OpenAIRE

    Levéziel, Hubert; Payet-Duprat, Nathalie; Hocquette, Jean-François; Lepetit, Jacques; Rousset, Sylvie; Denoyelle, Christophe; Bernard-Capel, Carine; Journaux, L.; Bonnot, Aline; Renand, Gilles

    2010-01-01

    The availability of genetic tests to detect different mutations in the myostatin gene allows the identification of heterozygous animals and would warrant the superiority of these animals for slaughter performance if this superiority is confirmed. Thus, 2 mutations of this gene, Q204X and nt821, were studied in 3 French beef breeds in the program Qualvigène. This work was done with 1,114 Charolais, 1,254 Limousin, and 981 Blonde d’Aquitaine young bulls from, respectively, 48, 36, and 30 sires ...

  9. The two mutations, Q204X and nt821, of the myostatin gene affect carcass and meat quality in young heterozygous bulls of French beef breeds.

    Science.gov (United States)

    Allais, S; Levéziel, H; Payet-Duprat, N; Hocquette, J F; Lepetit, J; Rousset, S; Denoyelle, C; Bernard-Capel, C; Journaux, L; Bonnot, A; Renand, G

    2010-02-01

    The availability of genetic tests to detect different mutations in the myostatin gene allows the identification of heterozygous animals and would warrant the superiority of these animals for slaughter performance if this superiority is confirmed. Thus, 2 mutations of this gene, Q204X and nt821, were studied in 3 French beef breeds in the program Qualvigène. This work was done with 1,114 Charolais, 1,254 Limousin, and 981 Blonde d'Aquitaine young bulls from, respectively, 48, 36, and 30 sires and slaughtered from 2004 to 2006. In addition to the usual carcass traits recorded at slaughter (e.g., carcass yield, muscle score), carcass composition was estimated by weighing internal fat and dissecting the 6th rib. The muscle characteristic traits analyzed were lipid and collagen contents, muscle fiber section area, and pH. Regarding meat quality, sensory qualities of meat samples were evaluated by a taste panel, and Warner-Bratzler shear force was measured. Deoxyribonucleic acid was extracted from the blood samples of all calves, the blood samples of 78% of the dams, and the blood or semen samples of all the sires. Genotypes were determined for 2 disruptive mutations, Q204X and nt821. Analyses were conducted by breed. The superiority of carcass traits of calves carrying one copy of the mutated allele (Q204X or nt821) over noncarrier animals was approximately +1 SD in the Charolais and Limousin breeds but was not significant in the Blonde d'Aquitaine. In the Charolais breed, for which the frequency was the greatest (7%), young bulls carrying the Q204X mutation presented a carcass with less fat, less intramuscular fat and collagen contents, and a clearer and more tender meat than those of homozygous-normal cattle. The meat of these animals also had slightly less flavor. Also in the Charolais breed, 13 of 48 sires were heterozygous. For each sire, the substitution effect of the wild allele by the mutant allele was approximately +1 SD for carcass conformation and yield

  10. Validation of expression patterns for nine miRNAs in 204 lymph-node negative breast cancers.

    Directory of Open Access Journals (Sweden)

    Kristin Jonsdottir

    Full Text Available INTRODUCTION: Although lymph node negative (LN- breast cancer patients have a good 10-years survival (∼85%, most of them still receive adjuvant therapy, while only some benefit from this. More accurate prognostication of LN- breast cancer patient may reduce over- and under-treatment. Until now proliferation is the strongest prognostic factor for LN- breast cancer patients. The small molecule microRNA (miRNA has opened a new window for prognostic markers, therapeutic targets and/or therapeutic components. Previously it has been shown that miR-18a/b, miR-25, miR-29c and miR-106b correlate to high proliferation. METHODS: The current study validates nine miRNAs (miR-18a/b miR-25, miR-29c, miR-106b, miR375, miR-424, miR-505 and let-7b significantly correlated with established prognostic breast cancer biomarkers. Total RNA was isolated from 204 formaldehyde-fixed paraffin embedded (FFPE LN- breast cancers and analyzed with quantitative real-time Polymerase Chain Reaction (qPCR. Independent T-test was used to detect significant correlation between miRNA expression level and the different clinicopathological features for breast cancer. RESULTS: Strong and significant associations were observed for high expression of miR-18a/b, miR-106b, miR-25 and miR-505 to high proliferation, oestrogen receptor negativity and cytokeratin 5/6 positivity. High expression of let-7b, miR-29c and miR-375 was detected in more differentiated tumours. Kaplan-Meier survival analysis showed that patients with high miR-106b expression had an 81% survival rate vs. 95% (P = 0.004 for patients with low expression. CONCLUSION: High expression of miR-18a/b are strongly associated with basal-like breast cancer features, while miR-106b can identify a group with higher risk for developing distant metastases in the subgroup of Her2 negatives. Furthermore miR-106b can identify a group of patients with 100% survival within the otherwise considered high risk group of patients with

  11. 超高效液相色谱-四极杆-飞行时间质谱法快速筛查茶叶中的204种农药残留%Rapid determination of 204 pesticide residues in tea by ultra performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry

    Institute of Scientific and Technical Information of China (English)

    余璐; 宋伟; 吕亚宁; 赵暮雨; 周芳芳; 胡艳云; 郑平

    2015-01-01

    An analytical method was established for the simultaneous determination of 204 pes-ticide residues in tea by ultra performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry( UPLC-Q-TOF/MS). The samples were extracted with acetonitrile, and cleaned-up by solid phase extraction( SPE)with a Carb-PSA cartridge,eluted with aceto-nitrile-toluene(3:1,v/v),determined by UPLC-Q-TOF/MS and quantified by external standard method. A data base of the accurate mass numbers and a library which contains the 204 pesti-cides were established. The automatic retrieval of detection results was carried on according to the characteristics of the compound,such as accurate mass,retention time,isotopic ratio,and so on. Based on the above results,the qualitative identifications of the 204 pesticides were accomplished without the contrast of standard substances. The results indicated that this meth-od can be used to determine the 204 pesticides in tea. At the three spiked levels of 10,20,50μg/kg,mean recoveries for the 204 pesticides in tea were between 68. 1% and 117. 2%,with the relative standard deviations( RSDs)ranging from 3. 1% to 18. 9%. The limits of quantifica-tion for the 204 pesticides were lower than 10 μg/kg. The method has been applied to four posi-tive samples,and the results generally accord with the detection results by the method of GB/T 23205-2008. This method has the characteristics of high efficiency,as well as high sensitivity and accuracy,which can meet the requirement of the determination of the 204 pesticides in tea.%利用超高效液相色谱-四极杆-飞行时间质谱( UPLC-Q-TOF/MS)技术建立了茶叶中204种农药残留的快速筛查和确证检测方法。样品采用乙腈提取,经 Carb-PSA 固相萃取小柱净化,用乙腈-甲苯(3:1,v/v)洗脱,采用UPLC-Q-TOF/MS检测,外标法定量。建立了204种农药的一级精确质量数据库和二级谱图库,通过化合物的精确质量数

  12. Pahute Mesa Well Development and Testing Analyses for Wells ER-20-8 and ER-20-4, Nevada National Security Site, Nye County, Nevada, Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Greg Ruskauff and Sam Marutzky

    2012-09-01

    Wells ER-20-4 and ER-20-8 were drilled during fiscal year (FY) 2009 and FY 2010 (NNSA/NSO, 2011a and b). The closest underground nuclear test detonations to the area of investigation are TYBO (U-20y), BELMONT (U-20as), MOLBO (U-20ag), BENHAM (U-20c), and HOYA (U-20 be) (Figure 1-1). The TYBO, MOLBO, and BENHAM detonations had working points located below the regional water table. The BELMONT and HOYA detonation working points were located just above the water table, and the cavity for these detonations are calculated to extend below the water table (Pawloski et al., 2002). The broad purpose of Wells ER-20-4 and ER-20-8 is to determine the extent of radionuclide-contaminated groundwater, the geologic formations, groundwater geochemistry as an indicator of age and origin, and the water-bearing properties and hydraulic conditions that influence radionuclide migration. Well development and testing is performed to determine the hydraulic properties at the well and between other wells, and to obtain groundwater samples at the well that are representative of the formation at the well. The area location, wells, underground nuclear detonations, and other features are shown in Figure 1-1. Hydrostratigraphic cross sections A-A’, B-B’, C-C’, and D-D’ are shown in Figures 1-2 through 1-5, respectively.

  13. Tank Vapor Characterization Project: Headspace vapor characterization of Hanford Waste Tank 241-C-204: Results from samples collected on 07/02/96

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, B.L.; Evans, J.C.; Pool, K.H. [and others

    1997-01-01

    This report describes the analytical results of vapor samples taken from the headspace of the waste storage tank 241-C-204 (Tank C-204) at the Hanford Site in Washington State. The results described in this report were obtained to characterize the vapors present in the tank headspace and to support safety evaluations and tank farm operations. The results include air concentrations of selected inorganic and organic analytes and grouped compounds from samples obtained by Westinghouse Hanford Company (WHC) and provided for analysis to Pacific Northwest National Laboratory (PNNL). Analyses were performed by the Vapor Analytical Laboratory (VAL) at PNNL. Analyte concentrations were based on analytical results and, where appropriate, sample volumes provided by WHC. A summary of the inorganic analytes, permanent gases, and total non-methane organic compounds is listed in Table S.1. The three highest concentration analytes detected in SUMMA{trademark} canister and triple sorbent trap samples are also listed in Table S.1. Detailed descriptions of the analytical results appear in the appendices.

  14. Measurement of the neutron capture cross section of the s-only isotope 204Pb from 1 eV to 440 keV

    CERN Document Server

    Domingo-Pardo, C; Aerts, G; Alvarez-Pol, H; Alvarez-Velarde, F; Andriamonje, S; Andrzejewski, J; Assimakopoulos, P; Audouin, L; Badurek, G; Baumann, P; Becvar, F; Berthoumieux, E; Bisterzo, S; Calvino, F; Cano-Ott, D; Capote, R; Carrapico, C; Cennini, P; Chepel, V; Chiaveri, E; Colonna, N; Cortes, G; Couture, A; Cox, J; Dahlfors, M; David, S; Dillmann, I; Dolfini, R; Dridi, W; Duran, I; Eleftheriadis, C; Embid-Segura, M; Ferrant, L; Ferrari, A; Ferreira-Marques, R; Fitzpatrick, L; Frais-Koelbl, H; Fujii, K; Furman, W; Gallino, R; Goncalves, I; Gonzalez-Romero, E; Goverdovski, A; Gramegna, F; Griesmayer, E; Guerrero, C; Gunsing, F; Haas, B; Haight, R; Heil, M; Herrera-Martinez, A; Igashira, M; Isaev, S; Jericha, E; Kadi, Y; Kappeler, F; Karamanis, D; Karadimos, D; Kerveno, M; Ketlerov, V; Koehler, P; Konovalov, V; Kossionides, E; Krticka, M; Lamboudis, C; Leeb, H; Lindote, A; Lopes, I; Lozano, M; Lukic, S; Marganiec, J; Marrone, S; Mastinu, P; Mengoni, A; Milazzo, P.M; Moreau, C; Mosconi, M; Neves, F; Oberhummer, H; Oshima, M; O'Brien, S; Pancin, J; Papachristodoulou, C; Papadopoulos, C; Paradela, C; Patronis, N; Pavlik, A; Pavlopoulos, P; Perrot, L; Plag, R; Plompen, A; Plukis, A; Poch, A; Pretel, C; Quesada, J; Rauscher, T; Reifarth, R; Rosetti, M; Rubbia, C; Rudolf, G; Rullhusen, P; Salgado, J; Sarchiapone, L; Savvidis, I; Stephan, C; Tagliente, G; Tain, J.L; Tassan-Got, L; Tavora, L; Terlizzi, R; Vannini, G; Vaz, P; Ventura, A; Villamarin, D; Vincente, M.C; Vlachoudis, V; Vlastou, R; Voss, F; Walter, S; Wendler, H; Wiescher, M; Wisshak, K

    2007-01-01

    The neutron capture cross section of 204Pb has been measured at the CERN n_TOF installation with high resolution in the energy range from 1 eV to 440 keV. An R-matrix analysis of the resolved resonance region, between 1 eV and 100 keV, was carried out using the SAMMY code. In the interval between 100 keV and 440 keV we report the average capture cross section. The background in the entire neutron energy range could be reliably determined from the measurement of a 208Pb sample. Other systematic effects in this measurement could be investigated and precisely corrected by means of detailed Monte Carlo simulations. We obtain a Maxwellian average capture cross section for 204Pb at kT=30 keV of 79(3) mb, in agreement with previous experiments. However our cross section at kT=5 keV is about 35% larger than the values reported so far. The implications of the new cross section for the s-process abundance contributions in the Pb/Bi region are discussed.

  15. Tank Vapor Characterization Project: Headspace vapor characterization of Hanford Waste Tank 241-C-204: Results from samples collected on 07/02/96

    International Nuclear Information System (INIS)

    This report describes the analytical results of vapor samples taken from the headspace of the waste storage tank 241-C-204 (Tank C-204) at the Hanford Site in Washington State. The results described in this report were obtained to characterize the vapors present in the tank headspace and to support safety evaluations and tank farm operations. The results include air concentrations of selected inorganic and organic analytes and grouped compounds from samples obtained by Westinghouse Hanford Company (WHC) and provided for analysis to Pacific Northwest National Laboratory (PNNL). Analyses were performed by the Vapor Analytical Laboratory (VAL) at PNNL. Analyte concentrations were based on analytical results and, where appropriate, sample volumes provided by WHC. A summary of the inorganic analytes, permanent gases, and total non-methane organic compounds is listed in Table S.1. The three highest concentration analytes detected in SUMMA trademark canister and triple sorbent trap samples are also listed in Table S.1. Detailed descriptions of the analytical results appear in the appendices

  16. NEW CATALYTIC SYSTEMS FOR THE FIXATION OF CO2 Ⅲ. INFLUENCE OF ADDITIVES AND REACTION MEDIUM ON THE COPOLYMERIZATION OF CARBON DIOXIDE-EPICHLOROHYDRIN IN THE PRESENCE OF Nd(P204)3-Al(i-Bu)3

    Institute of Scientific and Technical Information of China (English)

    CHEN Xianhai; ZHANG Yifeng; SHEN Zhiquan

    1994-01-01

    Copolymerization of carbon dioxide with epichlorohydrin was successfully carried out by using Nd (P204)3-A1 (i-Bu)3 as catalyst (P204) = (RO)2POO -, R=CH3 (CH2)3CH(C2H5)CH2-). Addition of carbonyl compounds into the catalyst decreased the carbon dioxide content of the copolymer to some extent. Compared to nonpolar solvents, ethereal and moderate polar solvents were favourable to obtaining higher carbon dioxide content copolymer. The coincidence of these results with the assumed copolymerization scheme clearly indicated that the copolymerization proceeds via coordinate anionic mechanism.

  17. Baruch Spinoza, Compendio di grammatica della lingua ebraica (a cura e con introduzione di Pina Totaro, traduzione e note di Massimo Gargiulo, Firenze, Olschki Editore, 2013, 204 pp. ISBN 978-88-222-6212-7

    Directory of Open Access Journals (Sweden)

    Sara Ferrari

    2014-11-01

    Full Text Available Baruch Spinoza, Compendio di grammatica della lingua ebraica(a cura e con introduzione di Pina Totaro, traduzione e note di Massimo Gargiulo, Firenze, Olschki Editore, 2013, 204 pp. ISBN 978-88-222-6212-7

  18. Separation of indium(Ⅲ),gallium(Ⅲ),and zinc(Ⅱ) with Levextrel resin containing di(2-ethylhexyl) phosphoric acid (CL-P204):Part Ⅱ.Mechanism and kinetics of adsorbing indium(Ⅲ)

    Institute of Scientific and Technical Information of China (English)

    LIU Junshen; ZHOU Baoxue; CAI Chunguang; CAI Jun; CAI Weimin

    2004-01-01

    The mechanism of adsorbing indium(Ⅲ) from sulfate solutions with CL-P204 Levextrel resin containing di(-2-ethylhexyl) phosphoric acid was examined by batch operation and infrared spectra. The results showed that the P204 adsorbed on the resin behaved in the similar way to solvent extraction except that it was as a monomer in resin adsorbing but in dimeric form in solvent extraction. Three factors including temperature, indium(Ⅲ) concentration of solution, and the size of resin particles which influence the In3+/H+ exchange on CL-P204 Levextrel resin were investigated by the modified limited batch technique in order to determine the kinetics of In3+/H+ exchange. It was found that the rate of ion exchange increased with the temperature and the concentration of solution increasing and with the size of the resin particles decreasing.According to the expression developed by Boyd et al., the controlling factor of In3+/H+ exchange on CL-P204 Levextrel resin was the diffusion through the resin particles. The effective diffusion coefficient, activation energy, and entropy of activation in the particle-diffusion were determined as 1.57 x l0-10 m2/s, 11.9 KJ/mol, -84.1 J/(mol. K), respectively.

  19. High-power 2.04  μm laser in an ultra-compact Ho-doped lead germanate fiber.

    Science.gov (United States)

    Kuan, Pei-Wen; Fan, Xiaokang; Li, Xia; Li, Dahai; Li, Kefeng; Zhang, Lei; Yu, Chunlei; Hu, Lili

    2016-07-01

    A highly Ho-doped single-mode lead germanate glass fiber is developed for compact ∼2  μm lasers. Over 600 mW of laser output operating at 2.04 μm is demonstrated in a 2 cm-long active fiber. The slope efficiency reaches ∼34.9% with respect to the launched 1.94 μm laser pump power. To the best of our knowledge, this is the highest laser output power demonstrated within a few centimeters of a Ho-doped fiber. This result shows that the fiber is highly promising for high-power single-frequency laser applications. PMID:27367060

  20. miR-204 Shifts the Epithelial to Mesenchymal Transition in Concert with the Transcription Factors RUNX2, ETS1, and cMYB in Prostate Cancer Cell Line Model

    Directory of Open Access Journals (Sweden)

    Krassimira Todorova

    2014-01-01

    Full Text Available Epithelial to mesenchymal transition is an essential step in advanced cancer development. Many master transcription factors shift their expression to drive this process, while noncoding RNAs families like miR-200 are found to restrict it. In this study we investigated how the tumor suppressor miR-204 and several transcription factors modulate main markers of mesenchymal transformation like E- and N-cadherin, SLUG, VEGF, and SOX-9 in prostate cancer cell line model (LNCaP, PC3, VCaP, and NCI-H660. We found that SLUG, E-cadherin, and N-cadherin are differentially modulated by miR-204, using miR-204 specific mimics and inhibitors and siRNA gene silencing (RUNX2, ETS-1, and cMYB. The genome perturbation associated TMPRSS2-ERG fusion coincided with shift from tumor-suppressor to tumor-promoting activity of this miRNA. The ability of miR-204 to suppress cancer cell viability and migration was lost in the fusion harboring cell lines. We found differential E-cadherin splicing corroborating to miR-204 modulatory effects. RUNX2, ETS1, and cMYB are involved in the regulation of E-cadherin, N-cadherin, and VEGFA expression. RUNX2 knockdown results in SOX9 downregulation, while ETS1 and cMYB silencing result in SOX9 upregulation in VCaP cells. Their expression was found to be also methylation dependent. Our study provides means for understanding cancer heterogeneity in regard to adapted therapeutic approaches development.

  1. 萃取分离电解锰阳极液中锰、镁离子试验研究%Separating of Manganese and Magnesium From Electrolytic Manganese Anode Solution Using P204

    Institute of Scientific and Technical Information of China (English)

    皮露; 何克杰; 罗炎; 孙维义; 丁桑岚; 苏仕军

    2015-01-01

    电解锰过程中,阳极液中的镁离子在闭路循环中会逐渐积累,使电流效率下降,能耗增大,同时也影响电解锰产品质量。研究了用P204‐磺化煤油溶液萃取分离阳极液中的锰离子和镁离子,分别考察了 P204体积分数、有机相皂化率、水相p H、相比等参数对锰离子和镁离子萃取率的影响。结果表明,在溶液温度35℃、P204体积分数25%、有机相皂化率50%、水相p H=4.0,V o ∶V a =2∶1的最佳条件下,经4级逆流萃取,锰离子萃取率达99.5%,镁离子萃取率为31.8%。%In the process of electrolytic manganese ,the magnesium ions in anode solution will gradually accumulated in closed cycle to reduce current efficiency and increase energy consumption ,and affect the quality of electrolytic manganese product .The separation of manganese and magnesium from the electrolytic manganese anode solution using P204 in sulfonated kerosene was investigated .The influence of several parameters on the extraction rate of manganese and magnesium were examined , such as P204 volume fraction in organic phase ,saponification rate of the organic phase ,water phase pH ,the ratio of organic phase volume to water phase volume .The results suggest that under the conditions of temperature of 35 ℃ ,P204 volume fraction of 25% ,organic phase saponification rate of 50% ,water phase pH of 4 .0 ,Vo ∶Va = 2∶1 ,and four‐stages countercurrent extraction ,satisfactory extraction efficiency (99 .5% ) of manganese ion is achieved ,while the extraction of magnesium is approximately 31 .8% ,manganese ion and magnesium ion are effectively separated at a low cost .

  2. Serine 204 phosphorylation and O-β-GlcNAC interplay of IGFBP-6 as therapeutic indicator to regulate IGF-II functions in viral mediated hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    Sarwar Muhammad T

    2011-05-01

    Full Text Available Abstract Hepatocellular carcinoma is mainly associated with viral hepatitis B and C. Activation of cell growth stimulator IGF-II gene is observed in tumor formation especially in viral associated hepatocellular carcinoma. Elevated IGF-II levels are indicator of increased risk for cholangiocellular and hepatocellular carcinomas through over saturation of IGF-II binding capacities with IGF receptors leading to cellular dedifferentiation. In HCV, core protein is believed to trans-activate host IGF-II receptor through PKC pathway and the inhibition of tumor cell growth can be achieved by blocking IGF-II pathway either at transcriptional level or increasing its binding with IGFBPs (Insulin like growth factor proteins at C-terminal, so that it is not available in free form. IGFBP-6 is a specific inhibitor of IGF-II actions. Affinity of IGFBPs with IGFs is controlled by post-translational modifications. Phosphorylation of IGFBPs inhibits IGFs action on target cells while O-glycosylation prevents binding of IGFBP-6 to glycosaminoglycans and cell membranes and resulting in a 10-fold higher affinity for IGF-II. O-glycosylation and phosphorylation operate the functional expression of cellular proteins, this switching on and off the protein expression is difficult to monitor in vivo. By using neural network based prediction methods, we propose that alternate O-β-GlcNAc modification and phosphorylation on Ser 204 control the binding of IGFBP-6 with IGF-II. This information may be used for developing new therapies by regulating IGFBP-6 assembly with IGF-II to minimize the risk of viral associated hepatocellular carcinoma. We can conclude that during HCV/HBV infection, O-β-GlcNAc of IGFBP-6 at Ser 204 diminish their binding with IGF-II, increase IGF-II cellular expression and promote cancer progression which can lead to hepatocellular carcinoma. Furthermore, this site can be used for developing new therapies to control the IGF-II actions during viral

  3. Phenotypic characteristics of a novel mutation rtM204Q in the reverse-transcriptase domain of hepatitis B virus isolated from a chronic hepatitis B patient receiving lamivudine treatment

    Directory of Open Access Journals (Sweden)

    Yan WANG

    2012-06-01

    Full Text Available Objective  To analyze the phenotypic characteristics of a novel mutation rtM204Q in the reverse-transcriptase (RT domain of hepatitis B virus (HBV. Methods  HBV DNA was isolated from a chronic hepatitis B patient receiving lamivudine treatment. The full-length RT region was amplified and the PCR product was cloned into the pGEM-Teasy vector. About 40 clones were randomly selected for DNA sequencing and drug-resistance-associated variation was analyzed. After restriction enzyme (XhoⅠ/SphⅠ digestion and ligation procedure, the 1.1-ploid genome length HBV recombinant plasmids harboring wild type and three different mutants in RT region were constructed. Then the replication-competent constructs pTriEx–wRT and pTriEx–mRT were transiently transfected into the HepG2 cells by FuGene® HD transfection reagent. Four hours post-transfection, new media containing different concentrations of nucleoside/nucleotide analogs (lamivudine: 0, 0.01, 0.1, 1, 10, 100μmol/L; adefovir: 0, 0.033, 0.1, 0.33, 1, 3.3μmol/L; entecavir: 0, 0.001, 0.01, 0.1, 1, 10μmol/L; tenofovir: 0, 0.01, 0.1, 1, 10, 100μmol/L were sequentially replaced every other day for 4 days. To analyze the phenotypic characteristics of the HBV mutant with different concentrations of the drug, the supernatant was collected and HBV DNA quantitation was done using real-time PCR. Results  Sequence analysis of 37 clones showed that there were five mutants in RT region, 13 (35.1% for wild type, 11 (29.7% for rtM204Q, 2 (5.4% for rtM204I, 10 (27.0% for rtA181T, and 1 (2.7% for rtA181T + rtM204Q. The relative replication capacity of the latter four mutants was 89.95%, 46.28%, 55.77% and 34.44% (P < 0.05 of wild-type strain, respectively. Phenotypic resistance analysis of the former two mutants showed that susceptibility of rtM204Q and rtM204I strains to lamivudine was 1/75.68 and 1/1000 respectively compared to the wild type strain, while their susceptibility to adefovir, entecavir and

  4. Exploring the effects of high-velocity flows in abundance determinations in H II regions. Bidimensional spectroscopy of HH 204 in the Orion Nebula

    CERN Document Server

    Núñez-Díaz, M; Esteban, C; López-Martín, L; García-Rojas, J; Luridiana, V

    2012-01-01

    We present results from integral field optical spectroscopy with the Potsdam Multi-Aperture Spectrograph of the Herbig-Haro (HH) object HH 204, with a spatial sampling of 1 x 1 arcsec^2. We have obtained maps of different emission lines, physical conditions and ionic abundances from collisionally excited lines. The ionization structure of the object indicates that the head of the bow shock is optically thick and has developed a trapped ionization front. The density at the head is at least five times larger than in the background ionized gas. We discover a narrow arc of high T_e([N II]) values delineating the southeast edge of the head. The temperature in this zone is about 1,000 K higher than in the rest of the field and should correspond to a shock-heated zone at the leading working surface of the gas flow. This is the first time this kind of feature is observed in a photoionized HH object. We find that the O^+ and O abundance maps show anomalous values at separate areas of the bow shock probably due to: a) ...

  5. Exploring the effects of high-velocity flows in abundance determinations in H II regions: bidimensional spectroscopy of HH 204 in the Orion nebula

    Science.gov (United States)

    Núñez-Díaz, M.; Mesa-Delgado, A.; Esteban, C.; López-Martín, L.; García-Rojas, J.; Luridiana, V.

    2012-04-01

    We present results from integral field optical spectroscopy with the Potsdam Multi-Aperture Spectrograph of the Herbig-Haro (HH) object HH 204, with a spatial sampling of 1 × 1 arcsec2. We have obtained maps of different emission lines, physical conditions and ionic abundances from collisionally excited lines. The ionization structure of the object indicates that the head of the bow shock is optically thick and has developed a trapped ionization front. The density at the head is at least five times larger than in the background ionized gas. We discover a narrow arc of high Te([N II]) values delineating the southeast edge of the head. The temperature in this zone is about 1000 K higher than in the rest of the field and should correspond to a shock-heated zone at the leading working surface of the gas flow. This is the first time this kind of feature is observed in a photoionized HH object. We find that the O+ and O abundance maps show anomalous values at separate areas of the bow shock probably due to: (a) overestimation of the collisional de-excitation effects of the [O II] lines in the compressed gas at the head of the bow shock, and (b) the use of a too high Te([N II]) at the area of the leading working surface of the flow.

  6. CD5 expression is regulated during human T-cell activation by alternative polyadenylation, PTBP1, and miR-204.

    Science.gov (United States)

    Domingues, Rita G; Lago-Baldaia, Inês; Pereira-Castro, Isabel; Fachini, Joseph M; Oliveira, Liliana; Drpic, Danica; Lopes, Nair; Henriques, Telmo; Neilson, Joel R; Carmo, Alexandre M; Moreira, Alexandra

    2016-06-01

    T lymphocytes stimulated through their antigen receptor (TCR) preferentially express mRNA isoforms with shorter 3´ untranslated regions (3´-UTRs) derived from alternative pre-mRNA cleavage and polyadenylation (APA). However, the physiological relevance of APA programs remains poorly understood. CD5 is a T-cell surface glycoprotein that negatively regulates TCR signaling from the onset of T-cell activation. CD5 plays a pivotal role in mediating outcomes of cell survival or apoptosis, and may prevent both autoimmunity and cancer. In human primary T lymphocytes and Jurkat cells we found three distinct mRNA isoforms encoding CD5, each derived from distinct poly(A) signals (PASs). Upon T-cell activation, there is an overall increase in CD5 mRNAs with a specific increase in the relative expression of the shorter isoforms. 3´-UTRs derived from these shorter isoforms confer higher reporter expression in activated T cells relative to the longer isoform. We further show that polypyrimidine tract binding protein (PTB/PTBP1) directly binds to the proximal PAS and PTB siRNA depletion causes a decrease in mRNA derived from this PAS, suggesting an effect on stability or poly(A) site selection to circumvent targeting of the longer CD5 mRNA isoform by miR-204. These mechanisms fine-tune CD5 expression levels and thus ultimately T-cell responses. PMID:27005442

  7. Characterization of the ground X1 state of 204Pb19F, 206Pb19F, 207Pb19F, and 208Pb19F

    International Nuclear Information System (INIS)

    Pure rotational spectra of the ground electronic-vibrational X1 state of 204Pb19F, 206Pb19F, 207Pb19F, and 208Pb19F are measured with a resonator pulsed supersonic jet Fourier-transform microwave spectrometer. Also reported is a new measurement of the Stark effect on the optical spectra of A(leftarrow)X1 transitions. These spectra are combined with published high-resolution infrared spectra of X2↔X1 transitions in order to create a complete picture of the ground state of lead monofluoride. For the microwave data, molecules are prepared by laser ablation of lead target rods and stabilized in a supersonic jet of neon mixed with sulfur hexafluoride. For the optical Stark spectra, a continuous source of molecules is created in a nozzle heated to 1000 deg. C. The microwave spectra confirm, improve, and extend previously reported constants that describe the rotational, spin-orbit, and hyperfine interactions of the ground electronic state of the PbF molecule. A discrepancy concerning the sign of the hyperfine constant describing the 207Pb nucleus is discussed. Magnetic-field-dependent microwave spectra are used to characterize the Zeeman interaction in terms of two g factors of the body-fixed electronic wave function. The optical Stark spectra are used to characterize the electric dipole moment of the X1 and A states.

  8. $^{204m}$Pb: A new Probe for TDPAC Experiments in Biology Complementing the Well Established Probes $^{111}$Cd and $^{199m}$Hg

    CERN Multimedia

    2002-01-01

    The short-lived nuclear probes $\\,^{111m}$Cd( t$_{1/2}$ = 49 min) , $^{199m}$Hg ( t$_{1/2}$ = 43 min) , and $^{204m}$Pb( t$_{1/2}$ = 43 min) supplied by ISOLDE are used to study the interaction of metals with biological macromolecules like, e.g., DNA and proteins. The structure and dynamics of metal sites in biomolecules are important in determining the functional efficiency of these macromolecules. Many life processes are based on such interactions. In order to study those metal sites close to physiological conditions a highly sensitive spectroscopic method is required, like Time Differential Perturbed Angular Correlation (TDPAC). Here, a radioactive atom is placed at the site of interest and by correlating the emitted $\\gamma$-quanta in space and on a nanosecond time scale local structural information is provided via the Nuclear Quadrupole Interaction. These investigations will allow a deeper insight into the adaptivity and rigidity of metal sites in the blue copper proteins (electron transfer proteins), th...

  9. In vivo detection of somatostatin receptors in patients with functionless pituitary adenomas by means of a radioiodinated analog of somatostatin ((123I)SDZ 204-090)

    Energy Technology Data Exchange (ETDEWEB)

    Faglia, G.; Bazzoni, N.; Spada, A.; Arosio, M.; Ambrosi, B.; Spinelli, F.; Sara, R.; Bonino, C.; Lunghi, F. (Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS (Italy))

    1991-10-01

    The recent availability of a Tyr3-substituted octreotide (SDZ 204-090) for radioiodination has allowed somatostatin (SRIH) receptor binding to be studied in vivo, and receptor-positive tumors of different origins to be visualized with a gamma-camera. This prompted us to investigate whether this compound could be used for external imaging of functionless pituitary adenomas displaying SRIH receptors. Eight patients with functionless pituitary adenomas, three patients with acromegaly, and three with macroprolactinoma were injected iv with 123I-labeled Tyr3-octreotide and then scanned with a gamma-camera. Positive scans were obtained in the three acromegalics and in two of the eight patients with functionless pituitary tumors. The patients with macroprolactinoma had negative scans. The diagnosis of functionless pituitary adenomas was confirmed by light and electron microscopic examination as well as immunocytochemical studies. In vitro binding of (125I)Tyr11-SRIH to cell membranes was evaluated in four functionless and three GH-secreting adenomas removed from seven of the patients. All of the GH-secreting as well as one of the four functionless adenomas had high affinity SRIH-binding sites, without differences in number or affinity, whereas SRIH-binding sites were not detected in the others. Positive scans were observed only in patients bearing tumors with high affinity SRIH-binding sites. In conclusion, (123I)Tyr3-octreotide appears to be a promising tool for singling out, in vivo, patients with functionless pituitary tumors displaying SRIH receptors who might potentially benefit from octreotide treatment.

  10. In vivo detection of somatostatin receptors in patients with functionless pituitary adenomas by means of a radioiodinated analog of somatostatin ([123I]SDZ 204-090)

    International Nuclear Information System (INIS)

    The recent availability of a Tyr3-substituted octreotide (SDZ 204-090) for radioiodination has allowed somatostatin (SRIH) receptor binding to be studied in vivo, and receptor-positive tumors of different origins to be visualized with a gamma-camera. This prompted us to investigate whether this compound could be used for external imaging of functionless pituitary adenomas displaying SRIH receptors. Eight patients with functionless pituitary adenomas, three patients with acromegaly, and three with macroprolactinoma were injected iv with 123I-labeled Tyr3-octreotide and then scanned with a gamma-camera. Positive scans were obtained in the three acromegalics and in two of the eight patients with functionless pituitary tumors. The patients with macroprolactinoma had negative scans. The diagnosis of functionless pituitary adenomas was confirmed by light and electron microscopic examination as well as immunocytochemical studies. In vitro binding of [125I]Tyr11-SRIH to cell membranes was evaluated in four functionless and three GH-secreting adenomas removed from seven of the patients. All of the GH-secreting as well as one of the four functionless adenomas had high affinity SRIH-binding sites, without differences in number or affinity, whereas SRIH-binding sites were not detected in the others. Positive scans were observed only in patients bearing tumors with high affinity SRIH-binding sites. In conclusion, [123I]Tyr3-octreotide appears to be a promising tool for singling out, in vivo, patients with functionless pituitary tumors displaying SRIH receptors who might potentially benefit from octreotide treatment

  11. Al掺杂的尖晶石型LiMn204的结构和电子性质%Structural and electronic properties of Al-doped spinel LiMn2 O4

    Institute of Scientific and Technical Information of China (English)

    高潭华; 刘慧英; 张鹏; 吴顺情; 杨勇; 朱梓忠

    2012-01-01

    采用基于密度泛函理论的第一性原理方法,在广义梯度近似(GGA)和GGA+U方法下对尖晶石型LiMn20。及其Al掺杂的尖晶石型LiAl0.125Mn1.875O4晶体的结构和电子性质进行了计算.结果表明:采用GGA方法得到尖晶石型LiMn204是立方晶系结构,其中的Mn离子为+3.5价,无法解释它的Jahn.Teller畸变.给出的LiMn204能带结构特征也与实验结果不符.而采用GGA+U方法得到在低温下的LiMn204和其掺杂体系LiAl0.125Mnl-87504的晶体都是正交结构,与实验一致.也能明确地确定Mn的两种价态Mn3+/Mn4+的分布并且能够说明Mna+06的z方向有明显的Jahn—Teller畸变,而Mn4+06则没有畸变.LiMn204的能带结构与实验比较也能够符合.采用GGA+U方法对Al掺杂体系的LiAl0.125Mnl.87504的研究表明,用Al替换一个Mn不会明显地改变晶体的电子性质,但可以有效地消除A13+06八面体的Jahn—Teller畸变,从而改善正极材料LiMn204的性能,这与电化学实验的观察结果相一致.%The structural and electronic properties of spinel LiMn204 and its A1 doping system LiAlo.125Mnl.s75Oa are investigated within the density functional theory in both the generalized gradient approximation (GGA) and the GGA with Hubbard U correc- tion (GGA+U). The results from the GGA method suggest that LiMn204 has a cubic structure and the valences of Mn ions are all +3.5, which is unable to explain the John-Teller distortions in the material. The band structure of LiMn204 predicted by the GGA method is also inconsistent with experimental result. With the GGA+U method, the low temperature structures of LiMn204 and its A1 doping system LiAlo.125Mnl.s7504 are shown to be orthogonal, the two different valence states of Mn, i.e., Mn3+/Mn4+ ions, are then determined, which is then able to explain the John-Teller distortion in octahedron Mna+O6 and the non-existence of distortion in octohedron Mn4+O6

  12. Pb(II) and Hg(II) binding to $\\textit{de novo}$ designed proteins studied by $^{204m}$Pb- and $^{199m}$Hg-Perturbed Angular Correlation of $\\gamma$-rays (PAC) spectroscopy : Clues to heavy metal toxicity

    CERN Multimedia

    2002-01-01

    $\\textit{De novo}$ design of proteins combined with PAC spectroscopy offers a unique and powerful approach to the study of fundamental chemistry of heavy metal-protein interactions, and thus of the mechanisms underlying heavy metal toxicity. In this project we focus on Pb(II) and Hg(II) binding to designed three stranded coiled coil proteins with one or two binding sites, mimicking a variety of naturally occurring thiolate-rich metal ion binding sites in proteins. The $^{204m}$Pb- and $^{199m}$Hg-PAC experiments will complement data already recorded with EXAFS, NMR, UV-Vis and CD spectroscopies.

  13. MO-E-17A-08: Attenuation-Based Size Adjusted, Scanner-Independent Organ Dose Estimates for Head CT Exams: TG 204 for Head CT

    International Nuclear Information System (INIS)

    Purpose: AAPM Task Group 204 described size specific dose estimates (SSDE) for body scans. The purpose of this work is to use a similar approach to develop patient-specific, scanner-independent organ dose estimates for head CT exams using an attenuation-based size metric. Methods: For eight patient models from the GSF family of voxelized phantoms, dose to brain and lens of the eye was estimated using Monte Carlo simulations of contiguous axial scans for 64-slice MDCT scanners from four major manufacturers. Organ doses were normalized by scannerspecific 16 cm CTDIvol values and averaged across all scanners to obtain scanner-independent CTDIvol-to-organ-dose conversion coefficients for each patient model. Head size was measured at the first slice superior to the eyes; patient perimeter and effective diameter (ED) were measured directly from the GSF data. Because the GSF models use organ identification codes instead of Hounsfield units, water equivalent diameter (WED) was estimated indirectly. Using the image data from 42 patients ranging from 2 weeks old to adult, the perimeter, ED and WED size metrics were obtained and correlations between each metric were established. Applying these correlations to the GSF perimeter and ED measurements, WED was calculated for each model. The relationship between the various patient size metrics and CTDIvol-to-organ-dose conversion coefficients was then described. Results: The analysis of patient images demonstrated the correlation between WED and ED across a wide range of patient sizes. When applied to the GSF patient models, an exponential relationship between CTDIvol-to-organ-dose conversion coefficients and the WED size metric was observed with correlation coefficients of 0.93 and 0.77 for the brain and lens of the eye, respectively. Conclusion: Strong correlation exists between CTDIvol normalized brain dose and WED. For the lens of the eye, a lower correlation is observed, primarily due to surface dose variations. Funding

  14. ECO 204 NEW Tutorial / Uoptutorial

    OpenAIRE

    Armugam

    2015-01-01

    For more course tutorials visit www.uoptutorial.com   Circular Flow Diagram. Explain how the circular flow diagram relates to the current economic situation. Using the circular flow diagram, explain a way that your family interacts in the factor market and a way that it interacts in the products market. Supply and Demand. Analyze how the law of demand applies to a recent purchase that you made. Describe how the product has changed in price and explain whether the price ch...

  15. 先天性心脏病相关性肺动脉高压患者血miR-18a、miR-27b、miR-130a、miR-204水平研究%The changes of plasma miR-18a, miR-27b, miR-130a, miR-204 in patients with pulmonary arterial hypertension due to congenital heart disease

    Institute of Scientific and Technical Information of China (English)

    吕宁; 戴海龙; 尹小龙

    2014-01-01

    目的 探索先天性心性脏病相关性肺动脉高压(PAH)患者血清中miR-18a、miR-27b、miR-130a和miR-204的表达水平,以及与PAH的相关性.方法 收集昆明医科大学附属延安医院心血管内科2012年4~12月被确诊为先天性心脏病的患者78例,其中肺动脉压正常组37例,合并轻、中度肺动脉高压组25例,重度肺动脉高压组16例;另设正常对照组20例.应用实时荧光定量PCR (Taqman探针法)检测miR-18a、miR-27b、miR-130a、miR-204在血液中的表达水平,分析先天性心脏病相关性肺动脉高压与miR-NA表达水平之间的关系.结果 先天性心脏病相关肺动脉高压患者血miR-18a、miR-27b、miR-130a表达水平显著上调,miR-204表达水平显著下调.随着肺动脉压力的不断增高,血miR-18a、miR-27b、miR-130a表达量明显升高,miR-204表达量显著下调.直线相关分析显示,先天性心脏病继发性肺动脉高压患者血miR-18a、miR-27b、miR-130a表达水平与肺动脉压力存在高度正相关关系(r=0.927,r=0.927,r=0.933,P<0.01),miR-204表达水平与肺动脉压力存在高度负相关关系(r=-0.773,P<0.01).结论 血miR-18a、miR-27b、miR-130a、miR-204水平可作为判断先天性心脏病合并肺动脉高压较好的临床血清学指标,预判价值较高.

  16. High-titer lactic acid production from NaOH-pretreated corn stover by Bacillus coagulans LA204 using fed-batch simultaneous saccharification and fermentation under non-sterile condition.

    Science.gov (United States)

    Hu, Jinlong; Zhang, Zhenting; Lin, Yanxu; Zhao, Shumiao; Mei, Yuxia; Liang, Yunxiang; Peng, Nan

    2015-04-01

    Lactic acid (LA) is an important chemical with various industrial applications. Non-food feedstock is commercially attractive for use in LA production; however, efficient LA fermentation from lignocellulosic biomass resulting in both high yield and titer faces technical obstacles. In this study, the thermophilic bacterium Bacillus coagulans LA204 demonstrated considerable ability to ferment glucose, xylose, and cellobiose to LA. Importantly, LA204 produces LA from several NaOH-pretreated agro stovers, with remarkably high yields through simultaneous saccharification and fermentation (SSF). A fed-batch SSF process conducted at 50°C and pH 6.0, using a cellulase concentration of 30 FPU (filter paper unit)/g stover and 10 g/L yeast extract in a 5-L bioreactor, was developed to produce LA from 14.4% (w/w) NaOH-pretreated non-sterile corn stover. LA titer, yield, and average productivity reached 97.59 g/L, 0.68 g/g stover, and 1.63 g/L/h, respectively. This study presents a feasible process for lignocellulosic LA production from abundant agro stovers.

  17. AB2O4型尖晶石材料的制备及其在可见光下的催化氧化特性%Preparation and Visible Light Photocatalytic Property of Spinel AB204 Nanophase Materials

    Institute of Scientific and Technical Information of China (English)

    刘楠; 姜妍彦; 唐乃玲

    2011-01-01

    AB2O4型尖晶石是一类窄带隙半导体材料,具有良好的可见光响应,呈现出的可见光光解水、可见光降解污染物和杀菌、灭菌的特性引起了人们的广泛关注,近年来取得了一系列的研究成果.本文简要介绍了AB2O4型尖晶石材料的制备方法,诸如固相法、液相法、气相法,比较了这些方法的优缺点,综述了这类光催化剂在可见光激发下光解水制氢、光催化降解污染物和杀菌、灭菌的特性,并对未来的研究方向进行了展望.%AB204-type spinel semiconductors with narrow band gap have attracted extensive attention because of their excellent visible light response. They are capable of producing water into hydrogen and oxygen, degrading the organic pollutants, disinfection and sterilization under visible-light irradiation. A series of research achievements about them have been completed in recent years. In this paper, the preparation methods and visible light photocatalytic property of AB204-type spinel materials were summarized. Finally, the research trend of the materials is also discussed.

  18. Irradiation performance and post-irradiation examinations of the instrumented sphere-pac UO2 assembly IFA-204, irradiated up to 1.7% FIMA in the Halden Boiling Water Reactor

    International Nuclear Information System (INIS)

    Fuel assembly IFA-204 consisted of four pins filled with a blend of three sizes of UO2 spheres. This blend was compacted in the zircaloy-4 cladding tube by vibration to achieve a 87-88% T.D. smear density of the 1500 mm long sphere-pac fuel column. IFA-204 was irradiated during 597 days, equivalent to 436 full power days, in the Halden BWR from November 1971 to April 1974 when the achieved assembly average burnup amounted to 13.7 MWd/kg UO2. Two of the four pins were equipped with fuel column length and pin length extensometers. The measurements showed that at average pin powers less than about 25 kW.m-1 only fuel-clad-thermal-interaction, FCTI, occurred. The clad thermal expansion coefficient was 4.8 ppm/kW.m-1. For calculations of the irradiation behaviour of sphere-pac LWR pins, filled with 0.1 MPa helium, with the Gapcon-Thermal-2 code a new thermal conductivity-temperature relationship has been developed. The calculated data agreed reasonably well with the measured data when taking into account a restructured fuel density of 90% T.D., a fuel surface roughness of 1 μm, the absence of a fuel-cladding gap and an effective full power fuel restructuring time of 40 days. It is concluded that the porous structure of the sphere-pac fuel column, whether restructured or not, has the inherent disadvantage of a high mobility of gaseous fission products and the inherent advantage of a practically stress free operation of the cladding

  19. 胃、十二指肠溃疡幽门螺杆菌感染及相关病因回顾性分析204例%Helicobacter pylori infection and other risk factors associated with peptic ulcers:an analysis of 204 cases

    Institute of Scientific and Technical Information of China (English)

    孙保华; 卢世云; 陈登登; 潘秀珍

    2011-01-01

    AIM: To study the impact of Helicobacter pylori (H.pylori) infection and other risk factors on the development of gastric ulcer (GU) and duodenal ulcer (DU).METHODS: A total of 204 patients who were treated at our hospital from 2003 to 2008 were included.The association of H.pylori infection status (14C-UBT), endoscopic findings, personal habits (smoking, alcohol intake), and medication (non-steroidal anti-inflammatory drugs (NSAIDs), aspirin intake) with the development of GU and DU was investigated using multiway frequency analysis.RESULTS: GU in the presence of H.pylori had significant association with aspirin (P = 0.0010),alcohol (P = 0.0091) and NSAIDs (P = 0.0321).DU in the presence of H.pylori had significant association with aspirin/smoking/NSAIDs (P = 0.0256), aspirin/alcohol (P = 0.0020) and aspirin/smoking (P = 0.0221).In the absence of H.pylori, GU had significant association with alcohol/NSAIDs (P = 0.0435) and NSAIDs (P = 0.0431), while DU had significant association with smoking/alcohol/NSAIDs (P = 0.0014), aspirin/NSAIDs (P = 0.0331), and aspirin/alcohol (P = 0.0032).CONCLUSION: In the presence of H.pylori,intake of aspirin, alcohol or NSAIDs acts as independent risk factors for the occurrence of GU but affects the occurrence of DU only when combined together.%目的:研究福建省立医院胃、十二指肠溃疡患者幽门螺杆菌(H.pylori)感染及其他致病因素对疾病发生的作用.方法:选取2003-2008年福建省立医院胃镜中心进行检查并确诊为消化性溃疡的患者204例,所有患者在胃镜检查前记录详细情况,包括H.pylori感染,胃黏膜活检尿素酶法(14C-UBT),吸烟史(每日>10支),饮酒史,非甾体类药物服用史.结果:H.pylori阳性的胃溃疡患者与阿司匹林(P=0.0010)、饮酒(P=0.0091)和其他非甾体类服用(P=0.0321)单独因素间呈显著性相关:H.pylori阳性的十二指肠溃疡与吸烟、饮酒、其他非甾体类服用三者共同作用呈显著性相关(P=0.0256),与

  20. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  1. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  2. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  3. Characterization of the ground X{sub 1} state of {sup 204}Pb{sup 19}F, {sup 206}Pb{sup 19}F, {sup 207}Pb{sup 19}F, and {sup 208}Pb{sup 19}F

    Energy Technology Data Exchange (ETDEWEB)

    Mawhorter, Richard J.; Murphy, Benjamin S.; Baum, Alexander L.; Sears, Trevor J.; Yang, T.; Rupasinghe, P. M; McRaven, C. P.; Shafer-Ray, N. E.; Alphei, Lukas D.; Grabow, Jens-Uwe [Department of Physics and Astronomy, Pomona College, Claremont, California 91711-6327 (United States); Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973-5000 (United States); Homer L. Dodge Department of Physics and Astronomy, University of Oklahoma, Norman, Oklahoma (United States); Gottfried-Wilhelm-Leibniz-Universitaet, Institut fuer Physikalische Chemie and Elektrochemie, Lehrgebiet A, D-30167 Hannover (Germany)

    2011-08-15

    Pure rotational spectra of the ground electronic-vibrational X{sub 1} state of {sup 204}Pb{sup 19}F, {sup 206}Pb{sup 19}F, {sup 207}Pb{sup 19}F, and {sup 208}Pb{sup 19}F are measured with a resonator pulsed supersonic jet Fourier-transform microwave spectrometer. Also reported is a new measurement of the Stark effect on the optical spectra of A(leftarrow)X{sub 1} transitions. These spectra are combined with published high-resolution infrared spectra of X{sub 2}{r_reversible}X{sub 1} transitions in order to create a complete picture of the ground state of lead monofluoride. For the microwave data, molecules are prepared by laser ablation of lead target rods and stabilized in a supersonic jet of neon mixed with sulfur hexafluoride. For the optical Stark spectra, a continuous source of molecules is created in a nozzle heated to 1000 deg. C. The microwave spectra confirm, improve, and extend previously reported constants that describe the rotational, spin-orbit, and hyperfine interactions of the ground electronic state of the PbF molecule. A discrepancy concerning the sign of the hyperfine constant describing the {sup 207}Pb nucleus is discussed. Magnetic-field-dependent microwave spectra are used to characterize the Zeeman interaction in terms of two g factors of the body-fixed electronic wave function. The optical Stark spectra are used to characterize the electric dipole moment of the X{sub 1} and A states.

  4. 14 CFR 204.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... corporation or association organized under the laws of the United States or a State, the District of Columbia... transportation certificate issued under section 41103 of the Statute authorizing the transportation by aircraft... of the United States means: (1) An individual who is a citizen of the United States; (2)...

  5. 23 CFR 646.204 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS RAILROADS Railroad...: Active warning devices means those traffic control devices activated by the approach or presence of a... the use of which is governed by block signals or by centralized traffic control. Passive...

  6. 45 CFR 204.4 - Grant appeals.

    Science.gov (United States)

    2010-10-01

    ... material necessary. (3) If the response to the grantee is adverse to the grantee's position, the response...) Section 222(a) and (b) of the Social Security Amendments of 1972 (Pub. L. 92-603). (2) Section 426 of the Social Security Act (42 U.S.C. 262). (3) Section 707 of the Social Security Act (42 U.S.C. 907)....

  7. 42 CFR 66.204 - Application.

    Science.gov (United States)

    2010-10-01

    ... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING... subject area or areas in which the proposed research or training will be conducted; (2) The resources and facilities available for use by recipients of Awards in carrying out this research or training; (3) The...

  8. 47 CFR 25.204 - Power limits.

    Science.gov (United States)

    2010-10-01

    ... orbit shall not exceed 51 dBW in any 6 MHz band from 13.77 to 13.78 GHz. Automatic power control may be... elevation of the horizon viewed from the center of radiation of the antenna of the earth station and... as soon as the attenuating weather pattern subsides. The maximum power level for power...

  9. 40 CFR 204.54 - Test procedures.

    Science.gov (United States)

    2010-07-01

    ... to measure the sound level and to calculate the average sound level of portable air compressors on... discharge valve. The air discharge shall be piped clear of the test area or fed into an effective silencer. The sound pressure level due to the air discharge shall be at least 10 dB below the sound...

  10. 29 CFR 541.204 - Educational establishments.

    Science.gov (United States)

    2010-07-01

    ... department, the English department, the foreign language department, etc.; academic counselors who perform... establishment” includes special schools for mentally or physically disabled or gifted children, regardless...

  11. 5 CFR 950.204 - Local eligibility.

    Science.gov (United States)

    2010-01-01

    ... electronic technology that allows removal of the need for geographic restrictions on giving as determined by... its funds on an accrual basis in accordance with generally accepted accounting principles and that an... have accounting procedures acceptable to an installation auditor and the inspector general. (5) Have...

  12. 31 CFR 800.204 - Control.

    Science.gov (United States)

    2010-07-01

    ... SECURITY, DEPARTMENT OF THE TREASURY REGULATIONS PERTAINING TO MERGERS, ACQUISITIONS, AND TAKEOVERS BY...; (2) The reorganization, merger, or dissolution of the entity; (3) The closing, relocation, or... interests in companies and manages them for a period of time. Corporation B is a U.S. business. In...

  13. 5 CFR 2635.204 - Exceptions.

    Science.gov (United States)

    2010-01-01

    ... value of $18 and a book about the history of cartography with a market value of $15. The employee may accept the map or the book, but not both, since the aggregate value of these two tangible items exceeds... employee. Relevant factors in making such a determination include the history of the relationship...

  14. 7 CFR 1901.204 - Compliance reviews.

    Science.gov (United States)

    2010-01-01

    ... grants. (17) Section 601 Energy Impacted Area Development Assistance grants. (18) Nonprofit National... Review Officer will: (i) Observe the recipient's records, including records on the present membership by race, the handling of applications for use of the facility, the user rates and membership fees or...

  15. 32 CFR 204.5 - Fees.

    Science.gov (United States)

    2010-07-01

    ... Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS USER FEES... demand exists for a good, resource, or service, its market price will be determined using commercial... appropriate that reflect demand, level of service, and quality of the good or service. (ii) In the absence...

  16. 7 CFR 1205.204 - Voting.

    Science.gov (United States)

    2010-01-01

    .... Forms obtained via the Internet will be located at http://www.ams.usda.gov/Cotton. Upon request by... 20026-3704. Forms obtained via the Internet will be located at http://www.ams.usda.gov/Cotton. (d... through the Internet during the voting period. A completed and signed CN-100 and supporting...

  17. 50 CFR 217.204 - Mitigation.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKE OF MARINE MAMMALS INCIDENTAL TO..., respectively. If a marine mammal is detected within or approaching a distance 200 m from in-water pile driving... for impact pile driving (350 m) prior to in-water impact pile driving, operations shall not...

  18. 46 CFR 197.204 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... diver or bell, or between a diver and a bell, that supplies the diver or bell with a life-line, breathing gas, communications, power, and heat as appropriate to the diving mode or conditions. Vessel means... Institute “Code for Pressure Piping, Power Piping.” ASME Code means the American Society of...

  19. 48 CFR 952.204-2 - Security.

    Science.gov (United States)

    2010-10-01

    ... review, as defined at 48 CFR 904.401, of an uncleared applicant or uncleared employee, and must test the... drug, as defined in 10 CFR Part 707.4. All positions requiring access authorizations are deemed testing designated positions in accordance with 10 CFR Part 707. All employees possessing access authorizations...

  20. 7 CFR 20.4 - Definitions.

    Science.gov (United States)

    2010-01-01

    ..., beef, and any products thereof, and any other agricultural commodity the Secretary may designate... issued pursuant to § 20.5 such as class(es) of wheat, or staple length(s) of cotton. Mixed wheat shall be... place of business with respect to the transaction in the United States. (j) Marketing year....

  1. BDML Metadata: 204 [SSBD[Archive

    Lifescience Database Archive (English)

    Full Text Available tal Dynamics See details in Kyoda et al. (2013) Nucleic Acids Res 41, D732-D737. CC BY-NC-SA 0.150 f005a738-5451-4b62-addc-8...//ssbd.qbic.riken.jp/search/f005a738-5451-4b62-addc-88cad3451b37/ http://ssbd.qbic.riken.jp/omero/webclient/?show=dataset-152 ...

  2. 12 CFR 204.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... the funds serve a purpose in connection with its foreign or international business or that of other... equivalent received or held by a depository institution in the usual course of business and for which it has... equivalent received or held by the depository institution in the usual course of business for a special...

  3. Inclusive measurement of (p,πsup(-)xn) double charge exchange reactions on bismuth from threshold to 800 MeV

    International Nuclear Information System (INIS)

    The energy dependence of the total angle-integrated cross section for the production of astatine isotopes from (p,πsup(-)xn) double charge exchange reactions on bismuth (sup(209)Bi) was measured from 120 to 800 MeV using activation and radiochemical techniques. Chemical yields were estimated by direct radioassaying of sup(211)At activity in thin (approximately 1 mg/cmsup(2)), irradiated bismuth targets. Calculations of the contributions of secondary (2-step) reactions to these measured astatine yields were performed, based partially upon the observed sup(211)At activity although even at the highest energies, the contribution to products lighter than sup(207)At was negligible. These data for products with as many as 7 neutrons removed from the doubly coherent product (sup(210)At) display nearby gaussian shapes for the mass distributions of the astatine residues with the maximum occurring for about sup(204)At. The most probable momentum transfer deduced from these distributions for the initial πsup(-) production step was 335 MeV/c. The observed excitation functions display a behaviour similar to that observed for the yield of sup(210)Po from a (p,πsup(O)) reaction on sup(209)Bi, but radically different from that observed for inclusive πsup(-) reactions on a heavy nucleus. These data are discussed in terms of recent theoretical approaches to negative pion production from bismuth. In addition, a simple, schematic model is developed to treat the rapidly decreasing percentage of the total inclusive πsup(-) emission which is observed for this double charge exchange reaction. This model reflects the capacity of a nucleus to a source of internal energetic protons

  4. 49 CFR 571.204 - Standard No. 204; Steering control rearward displacement.

    Science.gov (United States)

    2010-10-01

    ... displacement. S1. Purpose and scope. This standard specifies requirements limiting the rearward displacement of..., trucks, and buses. However, it does not apply to walk-in vans. S3. Definitions. Steering column means a... torque from the steering wheel to the steering gear. S4Requirements. S4.1Vehicles manufactured...

  5. 12 CFR 204.125 - Foreign, international, and supranational entities referred to in §§ 204.2(c)(1)(iv)(E) and 204.8...

    Science.gov (United States)

    2010-01-01

    ... Atomic Energy Community. European Central Bank. European Coal and Steel Community. The European.... Caribbean Development Bank. Caribbean Free Trade Association Caribbean Regional Development Agency. Central American Bank for Economic Integration. The Central American Institute for Industrial Research...

  6. Measurement of dose speed absorbed in depth imparted by sources external secondary patterns of beta radiation. Part 1 Measurement of dose speed absorbed in the surface of soft fabric for isotopes of {sup 90}Sr/{sup 90}Y, {sup 147}Pm and {sup 204}TI; Medicion de rapidez de dosis absorbida en profundidad impartida por fuentes patrones secundarios de radiacion beta externos. Parte 1. Medicion de rapidez de dosis absorbida en la superficie de tejido blando para isotopos de {sup 90}Sr/{sup 90}Y, {sup 147}Pm y {sup 204}TI

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J.T. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1993-01-15

    The dose speed was measured absorbed for depth zero, (superficial) in soft equivalent fabric, for the secondary pattern{sup s} four sources of beta radiation, (Nr. 86): {sup 90}Sr/{sup 90}Y, (1850 MBq and 74 MBq respectively); {sup 147}Pm, (518 MBq) and {sup 204}TI, (18.5 MBq). The measurement is carried out to different distances of source-detecting separation, (11.0, 30.0 and 50.0 cm for the source of 1850 MBq, 30.0 cm for that of 74 MBq; 11.00 cm for the source of {sup 147}Pmand to contact for all the sources); maintaining the radiation sheaf aligned the one axis of symmetry of the detector, ({alpha} 0 degrees). The detector employed was a extrapolation chambers of variable electrodes and electrode fixed collector, (30 mm of diameter). In accordance with the principle of Bragg-Gray the volume of the chambers is varied and they register the variations of the current of collected ionization, correcting until for a maximum of thirteen correction factors that take into account the deviation to the suppositions that it establishes this principle. The certain values of the speed of superficial absorbed dose are in the following intervals: {sup 90}Sr/{sup 90}Y, (1850 MBq, 0.0, 11.0, 30.0 and 50.0 cm): 43.164 mGy S-t, 0.544 mGy s-1 ,0.075 mGy s{sup -1} and 0.027 mGy s{sup -1}, respectively, with a Global Analysis of the order of 1.17%, 1.17%, 1.14% and 1.66%, K J; {sup 90}Sr / {sup 90}Y, (74 MBq, 0.0 and 30 cm): 1.536 mGy s{sup -1} and 0.002 mGy s{sup -1}, with Global Analysis of 1.19.0% and 5.22%, (K = 1) respectively, for the {sup 147}Pm, (0.0 and 11.0 in the interval of: 0.36 {mu}Gy s{sup -1} and 0.43 {mu}Gy s{sup -1}, with one Global Analysis of 1 .42% and 4.28%, (K = 1), respectively; and finally for the {sup 204}TI, (0.0 cm) in the interval of 0.10 {mu}Gy s{sup -1} with a Global Analysis of 1.27%. He calculates of the Global Analysis one carries out of agreement with those recommendations of the BIPM. In all the cases of source-detecting arrangement with

  7. 基于聚亚甲基蓝和磁性/多孔壳纳米CoFe2O4/SiO2固定酶的葡萄糖生物传感器%Glucose biosensor based on a poly( methlene blue) and CoFe204/SiO2colloid modified platinum electrode

    Institute of Scientific and Technical Information of China (English)

    娄方明; 盛云云; 李群芳

    2011-01-01

    用循环伏安法将电子媒介体亚甲蓝电聚合在铂电极表面上,使其表面形成均匀的聚亚甲蓝膜,通过磁铁对磁性纳米材料的吸附作用将磁性纳米CoFe2O4/SiO2 吸附在聚亚甲蓝表面,接着先后吸附葡萄糖氧化酶和磁性纳米CoFe2O4/SiO2,最后用亚甲蓝包埋电极,从而制得葡萄糖氧化酶生物传感器.实验结果表明,该葡萄糖传感器的循环伏安图中氧化峰电流与葡萄糖的浓度在1.2×10-7~6.5×10-5 mol/L 范围内呈良好线性关系,相关系数r=0.9962,检出限为6.2×10-8 mol/L(S/N=3).%A good glucose biosensor was constructed based on a poly (methlene blue) and CoFe2O4/SiO2 nanoparticles modified Pt electrode. Poly (Methlene blue), CoFe204/SiO2 nanoparticles and glucose oxidase (GOD) was absorbed on electrode surface in succession. Finally, GOD and CoFe2O4/SiO2 nanoparticles were firmly immobilized on the electrode surface by the entrapment of poly (methlene blue). The biosensor has a linear responce over the concentraction of glucose in the range of 1.2 × 10-7 ~6. 5 × 10-5 moL/L with a detection limit of 6. 2 × 10-8 moL/L and a correlation coefficient of 0. 9962 ( S/N = 3 ). The biosensor exhibited high sensitivity, good repeatability and long-time stability.

  8. Dicty_cDB: CHM204 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 0 length of database: 80,480,566 effective HSP length: 17 effective length of query: 123 effective length of database: 78,821,179 eff...ective search space: 9695005017 effective search space u...ences better than 10.0: 0 length of query: 140 length of database: _,673,055,985 effective HSP length: 21 effective... length of query: 119 effective length of database: ^,756,834,679 effective search space: 5564063326801 effective

  9. Dicty_cDB: CFD204 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1 EST0132 Tamarix androssowii leaf Tamarix androssowii cDNA, mRNA sequence. 38 0.019 2 AC094635 |AC094635.10...445564.1 Mycoplasma pulmonis (strain UAB CTIP) complete genome; segment 2/3. 36 0.008 13 CF198537 |CF198537.

  10. 17 CFR 275.204-3 - Written disclosure statements.

    Science.gov (United States)

    2010-04-01

    ... hours prior to entering into any written or oral investment advisory contract with such client or... solely to the provision of investment advisory services (i) by means of written material or oral...) through the issuance of statistical information containing no expression of opinion as to the...

  11. 24 CFR 3280.204 - Kitchen cabinet protection.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Kitchen cabinet protection. 3280... Kitchen cabinet protection. (a) The bottom and sides of combustible kitchen cabinets over cooking ranges... is designed for the future installation of a cooking range, the metal hood and cabinet...

  12. 15 CFR 904.204 - Duties and powers of Judge.

    Science.gov (United States)

    2010-01-01

    ... during the proceeding to state his or her position concerning any issue or his or her theory in support... statute or regulation; (p) Grant preliminary or interim relief; or (q) Impose, upon the motion of...

  13. 48 CFR 511.204 - Solicitation provisions and contract clauses.

    Science.gov (United States)

    2010-10-01

    ... Schedule containing information technology Special Item Numbers; or (ii) Federal Supply Schedules for... contracting officer shall include the clause 552.211-92, Radio Frequency Identification (RFID) using Passive... Consolidated Products and Services Schedule containing information technology Special Item Numbers; or...

  14. 27 CFR 555.204 - Inspection of magazines.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Inspection of magazines... of magazines. Any person storing explosive materials shall inspect his magazines at least every seven... been unauthorized entry or attempted entry into the magazines, or unauthorized removal of the...

  15. 48 CFR 31.204 - Application of principles and procedures.

    Science.gov (United States)

    2010-10-01

    ... REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Commercial... certain items for emphasis or clarity. (b)(1) For the following subcontract types, costs incurred...

  16. 44 CFR 204.3 - Definitions used throughout this part.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions used throughout... planning under the Fire Management Assistance Grant Program is to identify wildfire hazards and cost.... The ranking official responsible for overseeing the management of fire operations, planning,...

  17. 42 CFR 418.204 - Special coverage requirements.

    Science.gov (United States)

    2010-10-01

    ... individual only when necessary to relieve the family members or other persons caring for the individual. (2... consecutive days at a time. (c) Bereavement counseling. Bereavement counseling is a required hospice...

  18. 20.4.Intoxication and drug-related disease

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920183 Continuous observation of the elec-trocardiogram following experimental cere-bral hemorrhage.HAN Xiaoyu (韩筱玉),et al.Lanzhou Milit General Hosp.730050,Chin JNeurol & Psvchiat 1991; 24 (5): 295-296.Model of experimental cerebral bemorrage was

  19. 48 CFR 1652.204-71 - Coordination of Benefits.

    Science.gov (United States)

    2010-10-01

    ... insurance that pays benefits without regard to fault. (b) The Carrier shall not pay benefits under this... precedence established by the NAIC Model Guidelines for Coordination of Benefits (COB) as specified by OPM...) Changes in the order of precedence established by the NAIC Model Guidelines implemented after January 1...

  20. 48 CFR 952.204-75 - Public affairs.

    Science.gov (United States)

    2010-10-01

    ... stakeholder interactions. (c) The Contractor's internal procedures must ensure that all releases of... appropriate level within the Contractor's organization. (d) The Contractor must comply with DOE procedures for... of communication media, including public workshops, meetings or hearings, open houses,...

  1. 48 CFR 952.204-70 - Classification/Declassification.

    Science.gov (United States)

    2010-10-01

    ... possible while minimizing security costs. The Contractor or subcontractor shall insert this clause in any... Restricted Data” (classified under the Atomic Energy Act of 1954, as amended) and “National Security... documents (containing either Restricted Data or Formerly Restricted Data or National Security...

  2. 12 CFR 204.7 - Supplemental reserve requirement.

    Science.gov (United States)

    2010-01-01

    ... to increase the amount of reserves maintained to a level essential for the conduct of monetary policy... reserve ratios established by the Monetary Control Act of 1980 (Pub. L. 96-221) in effect on September...

  3. 48 CFR 952.204-72 - Disclosure of information.

    Science.gov (United States)

    2010-10-01

    ... educational institutions for research involving nuclear technology which could but is not expected to produce... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Disclosure of information... of information. As prescribed in 904.404(d)(4) this clause may be used in place of the...

  4. 18 CFR 1304.204 - Docks, piers, and boathouses.

    Science.gov (United States)

    2010-04-01

    ... structure of the maximum size, TVA shall determine the size of facility that may be approved. Applicants are... responsible for submitting plans for proposed docks, piers, and boathouses that conform to the size standards... structure. Access walkways to the water-use structure are not included in calculating the 1000-foot area....

  5. 41 CFR 50-204.5 - Machine guarding.

    Science.gov (United States)

    2010-07-01

    ... usually require point of operation guarding: Guillotine cutters. Shears. Alligator shears. Power presses. Milling machines. Power saws. Jointers. Portable power tools. Forming rolls and calenders. (d) Revolving... guarding device shall be so designed and constructed so as to prevent the operator from having any part...

  6. 12 CFR 308.204 - Enforcement of directives.

    Science.gov (United States)

    2010-01-01

    ... the directive in the appropriate United States district court pursuant to section 8(i)(1) of the FDI... to section 8(i)(2)(A) of the FDI Act, the FDIC may assess a civil money penalty against any bank that... to fulfill a guarantee of a capital restoration plan made pursuant to section 38(e)(2) of the FDI...

  7. 28 CFR 2.204 - Conditions of supervised release.

    Science.gov (United States)

    2010-07-01

    ... information indicates a low risk of future substance abuse by the releasee, shall constitute good cause for..., court costs or assessment, or court-ordered child support or alimony payment to which the releasee...

  8. 17 CFR 242.204 - Close-out requirement.

    Science.gov (United States)

    2010-04-01

    ... 600(b)(64) of Regulation NMS (17 CFR 242.600(b)(64)). Regulation ATS—Alternative Trading Systems...) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Regulation...

  9. Dicty_cDB: VHC204 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available lis mRNA for huntin... 72 4e-11 ( P51112 ) RecName: Full=Huntingtin; AltName: Full=Huntington... dise... 72 6e-11 L28827_1( L28827 |pid:none) Mouse Huntington's Disease gene homolo... 71 9e-11... ( P42859 ) RecName: Full=Huntingtin; AltName: Full=Huntington dise... 71 9e-11 AX460946_1( AX460946 |pid:no

  10. 32 CFR 204.9 - Schedule of fees and rates.

    Science.gov (United States)

    2010-07-01

    ... operations required to process the job will be maintained (i.e., time for central processing unit, input... or less. (b) Criteria for estimating cost of computerized records: (1) Costs for processing a...

  11. Weld solidification cracking in 304 to 204L stainless steel

    Energy Technology Data Exchange (ETDEWEB)

    Hochanadel, Patrick W [Los Alamos National Laboratory; Lienert, Thomas J [Los Alamos National Laboratory; Martinez, Jesse N [Los Alamos National Laboratory; Johnson, Matthew Q [Los Alamos National Laboratory

    2010-09-15

    A series of annulus welds were made between 304 and 304L stainless steel coaxial tubes using both pulsed laser beam welding (LBW) and pulsed gas tungsten arc welding (GTAW). In this application, a change in process from pulsed LBW to pulsed gas tungsten arc welding was proposed to limit the possibility of weld solidification cracking since weldability diagrams developed for GTAW display a greater range of compositions that are not crack susceptible relative to those developed for pulsed LBW. Contrary to the predictions of the GTAW weldability diagram, cracking was found.This result was rationalized in terms of the more rapid solidification rate of the pulsed gas tungsten arc welds. In addition, for the pulsed LBW conditions, the material compositions were predicted to be, by themselves, 'weldable' according to the pulsed LBW weldability diagram. However, the composition range along the tie line connecting the two compositions passed through the crack susceptible range. Microstructurally, the primary solidification mode (PSM) of the material processed with higher power LBW was determined to be austenite (A), while solidification mode of the materials processed with lower power LBW apparently exhibited a dual PSM of both austenite (A) and ferrite-austenite (FA) within the same weld. The materials processed by pulsed GTAW showed mostly primary austenite solidification, with some regions of either primary austenite-second phase ferrite (AF) solidification or primary ferrite-second phase austenite (FA) solidification. This work demonstrates that variations in crack susceptibility may be realized when welding different heats of 'weldable' materials together, and that slight variations in processing can also contribute to crack susceptibility.

  12. 14 CFR 125.204 - Portable electronic devices.

    Science.gov (United States)

    2010-01-01

    ...; (3) Heart pacemakers; (4) Electric shavers; or (5) Any other portable electronic device that the Part... system of the aircraft on which it is to be used. (c) The determination required by paragraph (b)(5)...

  13. 14 CFR 1274.204 - Costs and payments.

    Science.gov (United States)

    2010-01-01

    ... costs incurred by hospitals is determined in accordance with the provisions of Appendix E of 45 CFR part... variety of factors. For example, while the future profitability of intellectual property may serve as an... agreements awarded to commercial firms are subject to the cost accounting standards and principles of 48...

  14. 38 CFR 3.204 - Evidence of dependents and age.

    Science.gov (United States)

    2010-07-01

    ... name and relationship of the other person to the claimant; and, where the claimant's dependent child... question of its validity; the claimant's statement conflicts with other evidence of record; or, there is a... relationship in question. (Authority: 38 U.S.C. 5124) (b) Marriage or birth. The classes of evidence to...

  15. Dicty_cDB: VSA204 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ne 3D7, *** SEQUENCING IN PROGRESS ***, 4 unordered pieces. 36 0.001 6 BQ045548 |BQ045548.1 EST594665 P. infestans-challenge...mRNA sequence. 54 0.002 1 BQ047121 |BQ047121.1 EST596239 P. infestans-challenged potato leaf, incompatible r

  16. Dicty_cDB: SLF204 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available cine transmissible gastroenteritis virus RNA dependent RNA polymerase gene, partial cds; virus envelope prot... genes, complete cds; and unknown genes. 34 3.6 3 Z35758 |Z35758.1 Transmissible gastroenteritis virus TFI v

  17. 42 CFR 460.204 - Financial recordkeeping and reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... of accounting; and (2) Verifiable by qualified auditors. (b) Accrual accounting. A PACE organization must maintain an accrual accounting recordkeeping system that does the following: (1) Accurately... financial statements. (c) Accepted reporting practices. Except as specified under Medicare principles...

  18. 14 CFR 415.204-415.400 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... Schedule (§ 415.121) 7.1Launch Processing Schedule 8.0Computing Systems and Software (§ 415.123) 8... Descriptions 8.4Operator User Manuals and Documentation 8.5Software Hazard Analyses 8.6Software Test Plans, Test Procedures, and Test Results 8.7Software Development Plan 9.0Unique Safety Policies,...

  19. 8 CFR 204.304 - Improper inducement prohibited.

    Science.gov (United States)

    2010-01-01

    ... with the birth or any illness of the child; (4) Counseling services for a parent or a child for a... obtaining the home study; (7) Expenses incurred in obtaining the reports on the child as described in 8 CFR...) or anything of value (whether the value is great or small), directly or indirectly, to induce...

  20. 23 CFR 970.204 - Management systems requirements.

    Science.gov (United States)

    2010-04-01

    ... management systems are considered in the development of NPS transportation plans and PRPTIPs and in making... systems in enhancing transportation investment decision-making and improving the overall efficiency of the... as part of the NPS planning process. (g) The management systems shall be operated so...

  1. 48 CFR 3052.204-71 - Contractor employee access.

    Science.gov (United States)

    2010-10-01

    ... CFR 3004.470-3(b), insert a clause substantially the same as follows with appropriate alternates...) “Information Technology Resources” include, but are not limited to, computer equipment, networking equipment, telecommunications equipment, cabling, network drives, computer drives, network software, computer software,...

  2. 42 CFR 37.204 - Procedure for obtaining payment.

    Science.gov (United States)

    2010-10-01

    ... smoking cigarettes? 8. Total Years in Surface and Underground Employment in Coal Mining, by State (If... devoted the most number of years) (e.g., Same as above) 7. Smoking History of Miner: (a) Did he ever...

  3. 48 CFR 52.204-8 - Annual Representations and Certifications.

    Science.gov (United States)

    2010-10-01

    ... Officer: __(i) 52.219-19, Small Business Concern Representation for the Small Business Competitiveness... Under the Small Business Competitiveness Demonstration Program. ___(iii) 52.219-22, Small Disadvantaged... Classification System (NAICS) code for this acquisition is _______ . (2) The small business size standard...

  4. 15 CFR 971.204 - Environmental and use conflict analysis.

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR COMMERCIAL RECOVERY PERMITS... Administrator to prepare an environmental impact statement (EIS) on the proposed mining activities, and to... Administrator may require the submission of additional data, in the event he determines that the basis for...

  5. 15 CFR 970.204 - Environmental and use conflict analysis.

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS OF THE ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR EXPLORATION LICENSES... activities in the area, including the testing of integrated mining systems which simulate commercial recovery... baseline data or plans for acquiring them. The applicant may at his option delay submission of baseline...

  6. 8 CFR 204.311 - Convention adoption home study requirements.

    Science.gov (United States)

    2010-01-01

    ... worker, or professional substance abuse counselor, for an evaluation and written report, if the home... certification must also specify the basis under 22 CFR part 96 (public domestic authority, accredited agency... public domestic authority, as defined in 22 CFR 96.2. (u) Home study updates and amendments. (1) A...

  7. 40 CFR 92.204 - Designation of engine families.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) CONTROL OF AIR POLLUTION FROM LOCOMOTIVES AND LOCOMOTIVE ENGINES Certification Provisions § 92... exhaust aftertreatment system (oxidation catalyst, particulate trap), and characteristics of...

  8. 34 CFR 303.204 - Payments to the jurisdictions.

    Science.gov (United States)

    2010-07-01

    .... (a) From the sums appropriated to carry out this part for any fiscal year, the Secretary may reserve... respective needs. (b) The provisions of Pub. L. 95-134, permitting the consolidation of grants to...

  9. 17 CFR 204.65 - Wage garnishment order.

    Science.gov (United States)

    2010-04-01

    ... to thirty times the minimum wage See 29 CFR 870.10. (3) When a debtor's pay is subject to withholding... shall not be required to vary its normal pay and disbursement cycles in order to comply with the withholding order. (7) Any assignment or allotment by the employee of the employee's earnings shall be void...

  10. 34 CFR 682.204 - Maximum loan amounts.

    Science.gov (United States)

    2010-07-01

    ... coursework necessary for enrollment in a graduate or professional degree or certificate program for a student... total amount the student may borrow for any period of enrollment under the Unsubsidized Stafford Loan... for the period of enrollment for which the loan is intended, less— (1) The student's...

  11. 41 CFR 50-204.1 - Scope and application.

    Science.gov (United States)

    2010-07-01

    ... in which the work or part thereof is to be performed shall be prima-facie evidence of compliance with... prima facie evidence of compliance with the safety and health requirements of the Act and of any... obligation to provide protection for the health and safety of his employees in unusual employment...

  12. 5 CFR 575.204 - Ineligible categories of employees.

    Science.gov (United States)

    2010-01-01

    ... RECRUITMENT, RELOCATION, AND RETENTION INCENTIVES; SUPERVISORY DIFFERENTIALS; AND EXTENDED ASSIGNMENT... relocation incentive to an employee in— (a) A position to which an individual is appointed by the President... of two or more individual members; or (3) In which the employee is expected to receive an...

  13. 40 CFR 180.204 - Dimethoate; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... commodities: Commodity Parts per million Asparagus 0.15 Brussels sprouts 5.0 Cherry, sweet 2.0 Cherry, tart 2... Corn, field, stover 1.0 Corn, pop, grain 0.1 Corn, pop, stover 1.0 Corn, sweet, forage 1.0 Cotton... Orange 2.0 Pea 2.0 Pear 2.0 Pecan 0.1 Pepper 2.0 Potato 0.2 Poultry, meat byproducts 0.02 Safflower,...

  14. 5 CFR 362.204 - Development, evaluation, promotion, and certification.

    Science.gov (United States)

    2010-01-01

    ... addresses the core competencies required of the occupation or functional discipline in which the Fellow will... developmental activities designed to impart the competencies of the occupation or functional discipline in which... leadership, technical, and/or general competencies expected of the Fellow or Senior Fellow as well as...

  15. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE,CERN

    OpenAIRE

    Rothe, Sebastian

    2012-01-01

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spec...

  16. 7 CFR 205.204 - Seeds and planting stock practice standard.

    Science.gov (United States)

    2010-01-01

    ... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling... and planting stock may be used to produce an organic crop when an equivalent organically...

  17. 37 CFR 204.5 - Procedures for requesting access to records.

    Science.gov (United States)

    2010-07-01

    ... any working day except legal holidays at Room LM-401, The James Madison Memorial Building, 1st and... working days of receipt; and will notify the requester within 30 working days of receipt when and...

  18. 37 CFR 204.7 - Request for correction or amendment of records.

    Science.gov (United States)

    2010-07-01

    ... person between the hours of 8:30 a.m. and 5 p.m. on any working day except legal holidays, at Room LM-401... will respond within ten working days indicating to the requester that the requested correction...

  19. 37 CFR 204.4 - Procedure for notification of the existence of records pertaining to individuals.

    Science.gov (United States)

    2010-07-01

    ...,, Washington, DC 20024, or in person between the hours of 8:30 a.m. and 5 p.m. on any working day except legal holidays at Room LM-401, The James Madison Memorial Building, 1st and Independence Avenue, SE,...

  20. 40 CFR 141.204 - Tier 3 Public Notice-Form, manner, and frequency of notice.

    Science.gov (United States)

    2010-07-01

    ... copies in central locations (e.g., community centers). (d) In what situations may the Consumer Confidence Report be used to meet the Tier 3 public notice requirements? For community water systems, the Consumer Confidence Report (CCR) required under Subpart O of this part may be used as a vehicle for the initial Tier...

  1. 40 CFR 211.204-2 - Primary label size, print and color.

    Science.gov (United States)

    2010-07-01

    ... each area shall be as follows, based upon a scale of 72 points=1 inch: (1) Area A—2.8 millimeters (mm) or 8 point. (2) Area B—7.6 mm or 22 point for the Rating;—1.7 mm or 5 point for -“Decibels”. (3) Area... letters and the general appearance of the label must be similar to the example in Figure (1)....

  2. Yeast Interacting Proteins Database: YMR204C, YJL185C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available y (1) Rows with this prey as bait Rows with this prey as bait (0) Literature on bait (YPD) 3 Literature... on prey (YPD) 5 Literature shared by bait and prey 3 Literature sharing score 4 CuraG

  3. Herman Paul. (2011. Hayden White: The Historical Imagination. Cambridge: Polity Press [204 pp.

    Directory of Open Access Journals (Sweden)

    Ariel C. Lopez

    2011-12-01

    Full Text Available Ang akdang ito ni Herman Paul ay isang kritikal na pagsasakasaysayan(historicization ng mga ideya ni Hayden White na maibibilang sapinakamahahalagang pilosopo ng kasaysayan ng kontemporaryong panahon.Si White ay tanyag bilang simbolo par excellence ng postmodernistang kasaysayan na reaksyon laban sa noo’y, at hanggang ngayo’y, namamayaning positibistang pananaw (na inuugat sa Alemang historyador ng ika-19 na dantaon na si Leopold von Ranke. Noong Dekada ’50 pa lang, masusulyapan na ang pagsalungat ni White sa tradisyong positibista nang tawagin niya si Ranke bilang “kawawang nilalang na nagkandabulag sa paghahanap ng ‘kung ano ang tunay na nangyari’”(Paul, 2011, p.105. Para kay White, ang nakaraan per se (bilang nakaraan ay isang “walang-kahulugang katotohanan” (meaningless reality lamang. Binibigyang kahulugan ng mga historyador ang nakaraan sa pamamagitan ng mga naratibo na siyang humuhugis at nagtatakda sa kahulugan. Sa magnum opus ni White na pinamagatang Metahistory: The Historical Imagination in Nineteenth-Century Europe (1973, inilalatag niya ang ibat-ibang pagbabanghay (emplotment at tropos (tropesna implisitong sinusundan at sinasandigan ng mga (positibistang historyador upang magkaroon ng makatotohanang naratibo.

  4. Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation

    OpenAIRE

    Stahl, Mirjam; Schupp, Jonas; Jäger, Benedikt; Schmid, Michael; Zissel, Gernot; Müller-Quernheim, Joachim; Prasse, Antje

    2013-01-01

    Idiopathic pulmonary fibrosis is characterized by abundant collagen production and accumulation of alternatively activated macrophages (M2) in the lower respiratory tract. Mechanisms as to how alveolar macrophages are activated by collagen breakdown products are unknown. Alveolar macrophages were obtained by bronchoalveolar lavage from 30 patients with idiopathic pulmonary fibrosis (IPF) and 37 healthy donors (HD). Alveolar macrophages were cultured in the presence of collagen type I, III, IV...

  5. 5 CFR 430.204 - Agency performance appraisal system(s).

    Science.gov (United States)

    2010-01-01

    ... critical and non-critical elements may be appraised (as specified in § 430.206(b)(7) (i)(A) and (ii)(A... performance plans, including, but not limited to, critical elements and performance standards;...

  6. Orthodontic and dysfunctional abnormalities of stomatognatic apparatus: radiographic analysis of 204 subjects

    International Nuclear Information System (INIS)

    Two hundred and four subjects (86 males and 118 females), aged 8 to 35 years, with different types of malocclusion, underwent panoramic dental radiography and skull teleradiography. This study was aimed at investigating advantages and limitations of the two radiographic techniques, in view of their use as screening methods. On orthopan-tomography, inferior interincisive point, menthon (Me), and, bilaterally, gonion (Go) and condilion (Co), were localized so as to allow a model of the right and left jaws to be made. On teleradiography of the skull, in lateral view, Steiner's cephalometric analysis allowed skeletal classes to be evaluated according to ANB angle values. More-over, major postural parameters relative to the relationship between skull and cervical spine were analyzed: atlanto-occipital distance, cranio-vertebral angle, cervical lordosis, and hyoid triangle. Orthopan-tomography, though not a reproducible technique, can be considered as a valuable screening method for it allows right and left hemi-jaws to be comparatively measured. Cephalometric analysis of postural data confirmed the frequency of wrong postures in orthodontic patients. From the correlation of mandibular asymmetries and cranio-cervical parameters, the authors observed that asymmetrical patients have many postural problems, just like class II skeletal and dolico-facial types. This findings seems to confirm the mixed (functional and skeletal) etiopathogenesis of mandibular asymmetries

  7. 7 CFR 760.204 - Eligible livestock, honeybees, and farm-raised fish.

    Science.gov (United States)

    2010-01-01

    ..., goats, llamas, poultry, reindeer, sheep, or swine; (2) Be livestock that would normally have been... eligible loss condition, as a part of the normal business operation of the producer, as determined by the...) Non-adult buffalo or beefalo, (13) Non-adult dairy cattle, (14) Poultry, (15) Reindeer, (16)...

  8. Decree No. 80-204 of 11 March 1980 concerning mining rights

    International Nuclear Information System (INIS)

    This Decree repeals a Decree of 29 October 1970 on the same subject. However, it does not amend the Mining Code presently in Force, which contains provisions of substance governing mining resarch and exploitation. In connection with substances of use for atomic energy, any projects for taking out, modifying or suppressing mining rights must, as in the past, be submitted to the Committee for Atomic Energy before the file is forwarded to the General Council for Mines. It is now laid down that the Committee for Atomic Energy must take its decision within one month. The previous text contained no provision concerning a time-limit in this respect. (NEA)

  9. 12 CFR 204.134 - Linked time deposits and transaction accounts.

    Science.gov (United States)

    2010-01-01

    ... penalty. The arrangement may be marketed as providing the customer unlimited access to its funds with a... other than to allow the payment of higher interest through the avoidance of reserve requirements. As...

  10. CLOSURE REPORT FOR CORRECTIVE ACTION UNIT 204: STORAGE BUNKERS, NEVADA TEST SITE, NEVADA

    International Nuclear Information System (INIS)

    Corrective Action Unit (CAU) 330 consists of four Corrective Action Sites (CASs) located in Areas 6, 22, and 23 of the Nevada Test Site (NTS). The unit is listed in the Federal Facility Agreement and Consent Order (FFACO, 1996) as CAU 330: Areas 6, 22, and 23 Tanks and Spill Sites. CAU 330 consists of the following CASs: CAS 06-02-04, Underground Storage Tank (UST) and Piping CAS 22-99-06, Fuel Spill CAS 23-01-02, Large Aboveground Storage Tank (AST) Farm CAS 23-25-05, Asphalt Oil Spill/Tar Release

  11. Deep Ly alpha imaging of two z=2.04 GRB host galaxy fields

    DEFF Research Database (Denmark)

    Fynbo, J.P.U.; Møller, Per; Thomsen, Bente;

    2002-01-01

    - I colour than the eastern component, suggesting the presence of at least some dust. We do not detect the host galaxy of GRB 000301C in neither Lyalpha emission nor in U and I broad-band images. The strongest limit comes from combining the narrow and U-band imaging where we infer a limit of U...... the spectral slopes (f(lambda) proportional to lambda(beta)) of the two components to beta = 2.4 +/- 0.3 (east)and -1.4 +/- 0.2 (west). This implies that both components contain at most small amounts of dust, consistent with the observed strong Lyalpha emission. The western component has a slightly redder V......(AB) > 27.7 (2sigma limit per arcsec(2)). The upper limits on the Lyalpha flux implies a Lyalpha equivalent width upper limit of similar to150 Angstrom. We find eleven and eight other galaxies with excess emission in the narrow filter in the fields of GRB 000301C and GRB 000926 respectively. These galaxies...

  12. CLOSURE REPORT FOR CORRECTIVE ACTION UNIT 204: STORAGE BUNKERS, NEVADA TEST SITE, NEVADA

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-04-01

    Corrective Action Unit (CAU) 330 consists of four Corrective Action Sites (CASs) located in Areas 6, 22, and 23 of the Nevada Test Site (NTS). The unit is listed in the Federal Facility Agreement and Consent Order (FFACO, 1996) as CAU 330: Areas 6, 22, and 23 Tanks and Spill Sites. CAU 330 consists of the following CASs: CAS 06-02-04, Underground Storage Tank (UST) and Piping CAS 22-99-06, Fuel Spill CAS 23-01-02, Large Aboveground Storage Tank (AST) Farm CAS 23-25-05, Asphalt Oil Spill/Tar Release

  13. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (204a-0613-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  14. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (204b-0613-272217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National OceanService, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  15. 48 CFR 52.204-4 - Printed or Copied Double-Sided on Recycled Paper.

    Science.gov (United States)

    2010-10-01

    ...) All paper, paperboard, and fibrous materials that enter and are collected from municipal solid waste... Government through Waste Prevention, Recycling, and Federal Acquisition, the Contractor is encouraged...

  16. 14 CFR 204.3 - Applicants for new certificate or commuter air carrier authority.

    Science.gov (United States)

    2010-01-01

    ... in accordance with Generally Accepted Accounting Principles, and (ii) A description of the significant accounting policies of each relevant corporation, such as for depreciation, amortization of... statement identifying the person who has prepared the financial statements, his or her...

  17. Setting up and Running a School Library. Information Collection and Exchange Publication No. ED204

    Science.gov (United States)

    Baird, Nicola

    2012-01-01

    This book explains how teachers can set up and run a successful school library. In it you will find advice and information on how to: (1) set up a small library and build bookshelves; (2) select books for your library; (3) make a written record of your school's books, pamphlets and other library stock such as newspapers, magazines, audio tapes and…

  18. 47 CFR 15.204 - External radio frequency power amplifiers and antenna modifications.

    Science.gov (United States)

    2010-10-01

    ... lease), or import, ship, or distribute for the purpose of selling or leasing, any external radio... paragraph, refers to antennas that have similar in-band and out-of-band radiation patterns. (2) Compliance... the 5.725-5.825 GHz band pursuant to § 15.407 of this part. The amplifier must be of a design...

  19. 17 CFR 275.204-2 - Books and records to be maintained by investment advisers.

    Science.gov (United States)

    2010-04-01

    ... bank, broker or dealer by or through whom executed where appropriate. Orders entered pursuant to the exercise of discretionary power shall be so designated. (4) All check books, bank statements, cancelled checks and cash reconciliations of the investment adviser. (5) All bills or statements (or copies...

  20. 48 CFR 1852.204-76 - Security requirements for unclassified information technolocgy resources.

    Science.gov (United States)

    2010-10-01

    ... annual IT security training in NASA IT Security policies, procedures, computer ethics, and best practices..., documentation, databases, and personnel used in performance of the contract. Access shall be provided to...

  1. 7 CFR 761.204 - Methods of allocating funds to State Offices.

    Science.gov (United States)

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS GENERAL PROGRAM ADMINISTRATION Allocation of Farm Loan Programs... allocated to State Offices using one or more of the following allocation methods: (a) Formula allocation, if data, as specified in § 761.205, is available to use the formula for the State. (b)...

  2. 12 CFR 303.204 - Applications for acquisitions, branching, and new lines of business.

    Science.gov (United States)

    2010-01-01

    ... of the plan or otherwise further the purposes of section 38 of the FDI Act. If the FDIC is not the... the FDI Act (mergers and branches) (12 U.S.C. 1828 (c) or (d)), such applications should be filed concurrently with, or made a part of, the application filed pursuant to section 38 of the FDI Act (12...

  3. 25 CFR 162.204 - Must notice of applicable tribal laws and leasing policies be provided?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Must notice of applicable tribal laws and leasing... applicable tribal laws and leasing policies be provided? (a) A tribe must provide us with an official copy of any tribal law or leasing policy that supersedes or modifies these regulations under §§ 162.109 or...

  4. 24 CFR 203.204 - Requirements and limitations of a plan.

    Science.gov (United States)

    2010-04-01

    ... structural defect claim, Plans must, unless prohibited by applicable law, provide for binding arbitration... time of settlement. In the case of optional coverage beyond the coverage required under § 203.205, the... protection measures. (f) Unless prohibited by applicable law, Plans must, at a minimum, stipulate that...

  5. 18 CFR 292.204 - Criteria for qualifying small power production facilities.

    Science.gov (United States)

    2010-04-01

    ... primary energy source of the facility must be biomass, waste, renewable resources, geothermal resources... sources. (ii) Any primary energy source which, on the basis of its energy content, is 50 percent or more... FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY...

  6. Calibration of ground-based lidar instrument WLS7-204

    DEFF Research Database (Denmark)

    Gómez Arranz, Paula; Courtney, Michael

    This report presents the result of the lidar calibration performed for the given WLS7 Windcube at DTU’s test site for large wind turbine at Høvsøre, Denmark. Calibration is here understood as the establishment of a relation between the reference wind speed measurements with measurement uncertaint...

  7. CWSP Certified Wireless Security Professional Official Study Guide, Exam PW0-204

    CERN Document Server

    Coleman, David D; Harkins, Bryan E

    2010-01-01

    Sybex is now the official publisher for Certified Wireless Network Professional, the certifying vendor for the CWSP program. This guide covers all exam objectives, including WLAN discovery techniques, intrusion and attack techniques, 802.11 protocol analysis. Wireless intrusion-prevention systems implementation, layer 2 and 3 VPNs used over 802.11 networks, and managed endpoint security systems. It also covers enterprise/SMB/SOHO/Public-Network Security design models and security solution implementation, building robust security networks, wireless LAN management systems, and much more.

  8. 8 CFR 204.2 - Petitions for relatives, widows and widowers, and abused spouses and children.

    Science.gov (United States)

    2010-01-01

    ... might include the birth certificates of children born to the abuser and the spouse; police, medical, or...) Documentation showing commingling of financial resources; (4) Birth certificate(s) of child(ren) born to the... right to appeal in accordance with the provisions of 8 CFR 3.3. (4) Derivative beneficiaries. A child...

  9. 8 CFR 204.5 - Petitions for employment-based immigrants.

    Science.gov (United States)

    2010-01-01

    ... critical role for organizations or establishments that have a distinguished reputation; (ix) Evidence that..., along with managerial and/or consulting services, and markets its accounting services under an... from higher level executives, the board of directors, or stockholders of the organization....

  10. 48 CFR 51.204 - Use of interagency fleet management system (IFMS) vehicles and related services.

    Science.gov (United States)

    2010-10-01

    ... system (IFMS) vehicles and related services shall comply with the requirements of 41 CFR 101-39 and 41 CFR 101-38.301-1 and the operator's packet furnished with each vehicle. See 41 CFR 101-6.4 for... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Use of interagency...

  11. 12 CFR 347.204 - Commitment to be examined and provide information.

    Science.gov (United States)

    2010-01-01

    ... depository institution subsidiary of a foreign bank that has been determined to be subject to comprehensive... subsidiary of a foreign bank if the foreign bank fails to provide the written commitments, consent to U.S... institution subsidiary of the foreign bank. In addition, the FDIC may consider any additional assurances...

  12. 31 CFR 500.204 - Importation of and dealings in certain merchandise.

    Science.gov (United States)

    2010-07-01

    ..., North Viet-Nam, Cambodia, or South Viet-Nam. Articles which are the growth, produce or manufacture of... is North Korea, North Viet-Nam, Cambodia, or South Viet-Nam, notwithstanding that they may have been... merchandise whose country of origin is North Korea, North Viet-Nam, Cambodia, or South Viet-Nam, if......

  13. 24 CFR 1003.204 - Special activities by Community-Based Development Organizations (CBDOs).

    Science.gov (United States)

    2010-04-01

    ... economic development, or energy conservation project. The funded project activities may include those... jobs; (3) Energy conservation project includes activities that address energy conservation, principally... to its operations; and (iv) Maintains at least 51 percent of its governing body's membership for...

  14. 8 CFR 204.4 - Amerasian child of a United States citizen.

    Science.gov (United States)

    2010-01-01

    ... marriage certificate, if married, and evidence of the termination of any previous marriages, if applicable... intercountry placement of children has arranged the beneficiary's placement in the United States. Evidence must.... The evidence must demonstrate the agency's capability, including financial capability, to arrange...

  15. 48 CFR 809.204 - Responsibilities for establishment of a qualification requirement.

    Science.gov (United States)

    2010-10-01

    ...) It is in the Government's interest to be assured before contract award that the product is satisfactory for its intended use. (5) Determining acceptability would require providing product performance data to supplement technical requirements in the specification. (6) Conducting a test would result...

  16. 23 CFR 636.204 - What items may be included in a phase-one solicitation?

    Science.gov (United States)

    2010-04-01

    ... in any phase-one solicitation: (a) The scope of work; (b) The phase-one evaluation factors and their... price related factors, which are not permitted in phase-one); (c) Phase-two evaluation factors; and...

  17. 48 CFR 52.204-6 - Data Universal Numbering System (DUNS) Number.

    Science.gov (United States)

    2010-10-01

    ...) Via the Internet at http://fedgov.dnb.com/webform or if the offeror does not have internet access, it... business name. (ii) Tradestyle, doing business, or other name by which your entity is commonly recognized... of business (industry). (x) Company Headquarters name and address (reporting relationship within...

  18. Working Paper 204 - Skills and Youth Entrepreneurship in Africa: Analysis with Evidence from Swaziland

    OpenAIRE

    Zuzana Brixiova; Mthuli Ncube

    2014-01-01

    The shortages of entrepreneurial skillshave lowered search effectiveness of potential young entrepreneurs and the rate of youth start-ups. Our paper contributes to closing a gap in the entrepreneurship and development literature with a model of costly firm creation and skill differences between young and adult entrepreneurs. The model shows that for young entrepreneurs facing high cost of searching for business opportunities, support for training is more effective in stimulating productive st...

  19. 48 CFR 2928.204 - Alternatives in lieu of corporate or individual sureties.

    Science.gov (United States)

    2010-10-01

    ... DEPARTMENT OF LABOR GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Sureties and Other Security for... of the security and coordinate the retention of the security with the Chief Financial Officer. Contracting officers may obtain access to Department of Treasury Circular 570 through the Internet at...

  20. People and things. CERN Courier, June 1980, v. 20(4)

    International Nuclear Information System (INIS)

    The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events: On 25th April at a specially convened session of the CERN Council delegates of the twelve CERN Member States unanimously appointed Professor Herwig Schopper as Director General of CERN for the five years 1981-85; On 1 April, His Royal Highness Prince Charles went on a short tour of the TRIUMF site during a visit to Vancouver; An International Symposium on the History of Particle Physics was held at Fermilab from 28-31 May. It concentrated on the origins of particle physics back in the 1930s and 40s before the advent of the big particle accelerators; The Regents of the University of California have approved the formation of a new Institute for Particle Physics on its Santa Cruz Campus. Acronymed SCIPP (the Santa Cruz Institute for Particle Physics I it builds on the strength of existing groups of theoretical and experimental particle physicists; On 18 April, Fermilab brought into operation the world's largest helium liquefier plant; During a few shifts devoted to machine developments on 20 April, the stored beam of PETRA reached the design energy of 19 GeV. ; Earlier this year, a high energy physics meeting, organized by the Academia Sinica, was held in the pleasant winter climate of Guangzhou, Canton.; At a Physics Congress in Ulm the Chancellor of the Federal Republic of Germany, Helmut Schmidt, voiced his unambiguous support for fundamental research

  1. 40 CFR 204.59 - Recall of non-complying compressors.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recall of non-complying compressors... Recall of non-complying compressors. (a) Pursuant to section 11(d)(1) of the Act, the Administrator may issue an order to the manufacturer to recall and repair or modify any compressor distributed in...

  2. Compound list: simvastatin [Open TG-GATEs

    Lifescience Database Archive (English)

    Full Text Available simvastatin SST 00117 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/simv...astatin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/simv...astatin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/simv...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/simvastatin.Rat.in_vivo.Liver.Repeat.zip ...

  3. Study on 204 birth defects of the prenatal in the city of Taiyuan from 1997 to 2008%1997年-2008年太原地区204例出生缺陷回顾性分析

    Institute of Scientific and Technical Information of China (English)

    闫惠娜; 张月莲; 郑梅玲

    2012-01-01

    目的 了解1997年-2008年间太原市出生缺陷发生情况,为进一步制定干预措施提供依据.方法 将1997年-2008年12年中在我院妇产科终止妊娠的出生缺陷忠儿按年限分为1997年-2002年(前六年)组和2003年-2008年(后六年),并对其种类、发生率及城乡分布进行回顾性分析.结果 (1) 12年中神经管畸形的发生率为56.11/万,居于首位,占全部出生缺陷的32.35%,虽然后六年的神经管畸形的发生率低于前6年,但无统计学差异(x2=3.70,P>0.05).(2)后6年中28W前B超诊断率(1.12%)比前六年(0.41%)显著提高(x2=7.49,P<0.05).(3)前6年中城市与农村出生缺陷发生率分别为133.94/万、545.45/万,后6年城市与农村出生缺陷发生率分别为129.64/万、436.50/万,(x2=42.27,P<0.05; x2 =44.47,P<0.05)农村的平均发生率为城市的3.7倍,明显高于城市.结论 神经管畸形的发生在我省仍较为突出,只有加强对神经管畸形的预防,加强优生优育知识的宣传,改善农村生活环境,提高产前诊断率水平,才有可能有效性地降低出生缺陷的发生.%Objective: In order to formulate for further interventions, investigated the types, time of making a definite diagnosis, incidence of prenatal death defects in the city of Taiyuan, from 1997 to 2008. Methods; made two different groups, the first group form the year of 1997 to 2002 and the second group form the year of 2003 to 2008. Results: (1) The most of birth defects were Neural Tube defects and the percentage was 32. 35. (2) Morbidity by B ultrasound before 28w compare to after 28w were different between 1997 - 2002 and 2003 - 2008. (x2 = 7.49, P < 0.05 ) , the later six years' diagnostic rate of type - B ultrasonic before 28w was higher than the one of former six years. (3) Incidence of death defects were relate to the gravidas's place of residence, the gravidas' s birth defect rate form countries was higher than who form the cities whatever the first group or the second group, (x2 =42. 27 , P < 0.05 ;x2 = 44.47, P < 0.05 ). Conclusion: The most of birth defects were Neural Tube defects in Shanxi, to improve consciousness of maternal health care, to improve are effective measures to decrease the birth defect rate.

  4. 8 CFR 204.12 - How can second-preference immigrant physicians be granted a national interest waiver based on...

    Science.gov (United States)

    2010-01-01

    ... Medical Health Professional Shortage Area, or a Mental Health Professional Shortage Area, and in a medical... employers so as to adjust the count of the aggregate time served in an underserved area. This calculation... an underserved area. This calculation will be based on the evidence the physician submits pursuant...

  5. 5 CFR 2641.204 - One-year restriction on any former senior employee's representations to former agency concerning...

    Science.gov (United States)

    2010-01-01

    ... Schedule, within the meaning of the definition of senior employee in § 2641.104, the employee's hourly rate... paragraph (i): A former senior employee at the National Capital Planning Commission (NCPC) wishes to contact... senior employee's current business clients who have sought the introduction. The former senior...

  6. Oahu Hyperspectral Imagery 2000 (204c-0613-332211) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  7. 8 CFR 204.13 - How can the International Broadcasting Bureau of the United States Broadcasting Board of...

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false How can the International Broadcasting Bureau of the United States Broadcasting Board of Governors petition for a fourth preference special... Broadcasting Bureau of the United States Broadcasting Board of Governors petition for a fourth...

  8. SU-C-204-07: The Production of Short-Lived Positron Emitters in Proton Therapy

    International Nuclear Information System (INIS)

    Purpose: To investigate the production and effect of short-lived positron emitters when using PET for in-vivo range verification during a proton therapy irradiation. Methods: The integrated production of short-lived positron emitters in the stopping of 55 MeV protons was measured in water, carbon, phosphorus and calcium targets. The experimental production rates are used to calculate the production on PMMA and a representative set of 4 tissue materials. The number of decays integrated over an irradiation in these materials is calculated as function of the duration of the irradiation, considering irradiations with the same total number of protons. Results: The most copiously produced short-lived nuclides and their production rates relative to the relevant long-lived nuclides are: 12-N (T1/2 = 11 ms) on carbon (9.5% of the 11-C production), 29-P (T1/2 = 4.1 s) on phosphorus (20% of the 30-P production) and 38m-K (T1/2 = 0.92 s) on calcium (113% of the 38g-K production). No short-lived nuclides are produced on water. The most noticeable Result is that for an irradiation in (carbon-rich) adipose tissue, 12-N will dominate the PET image up to an irradiation duration of 70 s. On bone tissue, 15-O dominates over 12-N after 7–15 s (depending on the carbon-to-oxygen ratio). Conclusions: The presence of 12-N needs to be considered in PET imaging during proton beam irradiations as, depending on tissue composition and PET scanning protocol, it may noticeably deteriorate image quality due to the large positron range blurring. The results presented warrant investigations into the energy-dependent production of 12-N, 29-P and 38m-K and their effect on PET imaging during proton irradiations

  9. 9 CFR 93.204 - Import permits for poultry and for poultry test specimens for diagnostic purposes; and...

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Import permits for poultry and for poultry test specimens for diagnostic purposes; and reservation fees for space at quarantine facilities... SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND...

  10. 78 FR 1299 - Waiver and Certification of Statutory Provisions of Section 1003 of Public Law 100-204 Regarding...

    Science.gov (United States)

    2013-01-08

    ... between Israel and the Palestinians, and waive the provisions of section 1003 of the Anti-Terrorism Act of... Programs Appropriations Act, 2012 (Pub. L. 112-74, Div. I), as carried forward by the Continuing Appropriations Act, 2013, the Delegation of Authority in the President's Memorandum of July 21, 2010,...

  11. SU-C-204-05: Simulations of a Portal Imaging System for Conformal and Intensity Modulated Fast Neutron Therapy

    International Nuclear Information System (INIS)

    Purpose: The University of Washington Medical Center offers neutron therapy for the palliative and definitive treatment of selected cancers. In vivo field verification has the potential to improve the safe and effective delivery of neutron therapy. We propose a portal imaging method that relies on the creation of positron emitting isotopes (11C and 15O) through (n, 2n) reactions with a PMMA plate placed below the patient. After field delivery, the plate is retrieved from the vault and imaged using a reader that detects annihilation photons. The spatial pattern of activity produced in the PMMA plate provides information to reconstruct the neutron fluence map needed to confirm treatment delivery. Methods: We used MCNP to simulate the accumulation of 11C activity in a slab of PMMA 2 mm thick, and GATE was used to simulate the sensitivity and spatial resolution of a prototype imaging system. BGO crystal thicknesses of 1 cm, 2 cm and 3 cm were simulated with detector separations of 2 cm. Crystal pitches of 2 mm and 4 mm were evaluated. Back-projection of the events was used to create a planar image. The spatial resolution was taken to be the FWHM of the reconstructed point source image. Results: The system sensitivity for a point source in the center of the field of view was found to range from 58% for 1 cm thick BGO with 2 mm crystal pitch to 74% for the 3 cm thick BGO crystals with 4 mm crystal pitch. The spatial resolution at the center of the field of view was found to be 1.5 mm for the system with 2 mm crystal pitch and 2.8 mm for the system with the 4 mm crystal pitch. Conclusion: BGO crystals with 4 mm crystal pitch and 3 cm length would offer the best sensitivity reader

  12. Andrés Barba, Versiones de Teresa : Anagrama, Barcelona, 2006, 204 pp.

    OpenAIRE

    Pellicer, Gemma

    2008-01-01

    Andrés Barba (Madrid, 1975) se dio a conocer como escritor con la novela corta El hueso que más duele (Premio Ramón J. Sender 1997), a la que siguieron La hermana de Katia (finalista del Premio Herralde 2001), Ahora tocad música de baile (2004) y Versiones de Teresa (Premio Torrente Ballester 2005), la novela que aquí nos ocupa. También cuenta en su haber con un libro de relatos, La recta intención (2002) y otro infantil, Historia de nadas (2006). Licenciado en Filología Hispánica por la Univ...

  13. Multifrequency Radio Observations of a SNR in the LMC. The Case of SNR J0527-6549 (DEM L204

    Directory of Open Access Journals (Sweden)

    Bozzetto, L. M.

    2010-12-01

    Full Text Available We present a detailed study and results of new Australia Telescope Compact Array (ATCA observations of supernova remnant SNR J0527-6549. This Large Magellanic Cloud (LMC object follows a typical supernova remnant (SNR horseshoe morphology with a diameter of D=(66$imes$58$pm$1~pc which is among the largest SNRs in the LMC. Its relatively large size indicates older age while a steeper than expected radio spectral index of $alpha$=-0.92$pm$0.11 is more typical of younger and energetic SNRs. Also, we report detections of regions with a high order of polarization at a peak value of $sim$ 54 per cent $pm$ 17 per cent at 6~cm.

  14. Oahu Hyperspectral Imagery 2000 (204c-0613-272217) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  15. Oahu Hyperspectral Imagery 2000 (204b-0613-332211) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  16. Oahu Hyperspectral Imagery 2000 (204a-0613-272217) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  17. Oahu Hyperspectral Imagery 2000 (204a-0613-332211) - Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  18. Oahu Hyperspectral Imagery 2000 (204b-0613-272217)- Visual Interpretation from Remote Sensing Imagery Main Eight Hawaiian Islands

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort between the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment,...

  19. SU-C-204-07: The Production of Short-Lived Positron Emitters in Proton Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Buitenhuis, H J T; Dendooven, P; Biegun, A K; Goethem, M-J van; Graaf, E R van der; Brandenburg, S [University of Groningen, Groningen (Netherlands); Diblen, F [University of Groningen, Groningen (Netherlands); Ghent University, Ghent (Belgium)

    2015-06-15

    Purpose: To investigate the production and effect of short-lived positron emitters when using PET for in-vivo range verification during a proton therapy irradiation. Methods: The integrated production of short-lived positron emitters in the stopping of 55 MeV protons was measured in water, carbon, phosphorus and calcium targets. The experimental production rates are used to calculate the production on PMMA and a representative set of 4 tissue materials. The number of decays integrated over an irradiation in these materials is calculated as function of the duration of the irradiation, considering irradiations with the same total number of protons. Results: The most copiously produced short-lived nuclides and their production rates relative to the relevant long-lived nuclides are: 12-N (T1/2 = 11 ms) on carbon (9.5% of the 11-C production), 29-P (T1/2 = 4.1 s) on phosphorus (20% of the 30-P production) and 38m-K (T1/2 = 0.92 s) on calcium (113% of the 38g-K production). No short-lived nuclides are produced on water. The most noticeable Result is that for an irradiation in (carbon-rich) adipose tissue, 12-N will dominate the PET image up to an irradiation duration of 70 s. On bone tissue, 15-O dominates over 12-N after 7–15 s (depending on the carbon-to-oxygen ratio). Conclusions: The presence of 12-N needs to be considered in PET imaging during proton beam irradiations as, depending on tissue composition and PET scanning protocol, it may noticeably deteriorate image quality due to the large positron range blurring. The results presented warrant investigations into the energy-dependent production of 12-N, 29-P and 38m-K and their effect on PET imaging during proton irradiations.

  20. SU-D-204-01: Dual-Energy Calibration for Breast Density Measurement Using Spectral Mammography

    Energy Technology Data Exchange (ETDEWEB)

    Ding, H; Cho, H; Kumar, N; Sennung, D; Molloi, S [Department of Radiological Sciences, University of California, Irvine, CA (United States)

    2015-06-15

    Purpose: To investigate the feasibility of minimizing the systematic errors in dual-energy breast density quantification induced by the use of tissue-equivalent plastic phantoms as the calibration basis materials. Methods: Dual-energy calibration using tissue-equivalent plastic phantoms was performed on a spectral mammography system based on scanning multi-slit Si strip photon-counting detectors. The plastic phantom calibration used plastic water and adipose-equivalent phantoms as the basis materials, which have different x-ray attenuation properties compared to water and lipid in actual breast tissue. Two methods were used to convert the dual-energy decomposition measurements in plastic phantom thicknesses into true water and lipid basis. The first method was based entirely on the theoretical x-ray attenuation coefficients of the investigated materials in the mammographic energy range. The conversion matrix was determined from least-squares fitting of the target material using the reported attenuation coefficients of water and lipid. The second method was developed based on experimental calibrations, which measured the low-and high-energy signals of pure water and lipid of known thicknesses. A non-linear rational function was used to correlate the decomposed thicknesses to the known values, so that the conversion coefficients can be determined. Both methods were validated using independent measurements of water and lipid mixture phantoms. The correlation of the dual-energy decomposition measurements and the known values were studied with linear regression analysis. Results: There was an excellent linear correlation between the converted water thicknesses and the known values. The slopes of the linear fits were determined to be 0.63 and 1.03 for the simulation and experimental results, respectively. The non-linear fitting in the experimental approach reduced the root-mean-square (RMS) errors from approximately 3.4 mm to 1.5 mm. Conclusion: The results suggested that conversion of the dual-energy measurements into water and lipid thicknesses minimized the systematic errors in tissue decomposition studies.

  1. LOSCAR: Long-term Ocean-atmosphere-Sediment CArbon cycle Reservoir Model v2.0.4

    Directory of Open Access Journals (Sweden)

    R. E. Zeebe

    2012-01-01

    Full Text Available The LOSCAR model is designed to efficiently compute the partitioning of carbon between ocean, atmosphere, and sediments on time scales ranging from centuries to millions of years. While a variety of computationally inexpensive carbon cycle models are already available, many are missing a critical sediment component, which is indispensable for long-term integrations. One of LOSCAR's strengths is the coupling of ocean-atmosphere routines to a computationally efficient sediment module. This allows, for instance, adequate computation of CaCO3 dissolution, calcite compensation, and long-term carbon cycle fluxes, including weathering of carbonate and silicate rocks. The ocean component includes various biogeochemical tracers such as total carbon, alkalinity, phosphate, oxygen, and stable carbon isotopes. LOSCAR's configuration of ocean geometry is flexible and allows for easy switching between modern and paleo-versions. We have previously published applications of the model tackling future projections of ocean chemistry and weathering, pCO2 sensitivity to carbon cycle perturbations throughout the Cenozoic, and carbon/calcium cycling during the Paleocene-Eocene Thermal Maximum. The focus of the present contribution is the detailed description of the model including numerical architecture, processes and parameterizations, tuning, and examples of input and output. Typical CPU integration times of LOSCAR are of order seconds for several thousand model years on current standard desktop machines. The LOSCAR source code in C can be obtained from the author by sending a request to loscar.model@gmail.com.

  2. 国外新批准上市的药物新制剂新剂型(204

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    1美国FDA批准复方雷地帕韦(1edipasvir)/索夫布韦片上市美国FDA批准吉利德科学公司产品(商品名:Harvoni)上市,用于治疗慢性丙型肝炎病毒(HCV)基因1型感染。剂量规格:雷地帕韦/索夫布韦(sofosbuvir)90mg/400mg/片。

  3. 8 CFR 204.3 - Orphan cases under section 101(b)(1)(F) of the Act (non-Convention cases).

    Science.gov (United States)

    2010-01-01

    ... adult member of the prospective adoptive parents' household has been made with available child abuse... parents' household has a history of substance abuse, sexual or child abuse, and/or domestic violence, the... prospective adoptive parents' household to cooperate in having available child abuse registries checked...

  4. 8 CFR 204.309 - Factors requiring denial of a Form I-800A or Form I-800.

    Science.gov (United States)

    2010-01-01

    ... abuse, child abuse, and/or family violence, or any other criminal history as an offender; the fact that... any additional adult member of the household, failed to cooperate in having available child abuse... met with, or had any other form of contact with, the child's parents, legal custodian, or...

  5. Genotype data: 6 [

    Lifescience Database Archive (English)

    Full Text Available B204B HBHHBHAAHBHBHHAHAHBAHAABAHBBAAHHBHHHHAAHAHABABAHAHHABHHHHHHHBAAHHAABBHBABHHBA...BBBHHBAHHBHHHAAHHHAHHHAABAHHHHHHBABBHHHAABHHHAHABHHHAHBBHHHHHHHAAABBHHHHBBABAABHHAAAABABAHBBHBHBHHBHAABABHHHA ...

  6. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1995-12-01

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

  7. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity...

  8. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Science.gov (United States)

    2010-01-01

    .... Actinium Ac 89 Aluminum Al 13 Americium Am 95 Antimony Sb 51 Argon Ar 18 Arsenic As 33 Astatine At 85... Curium Cm 96 Dysprosium Dy 66 Einsteinium Es 99 Erbium Er 68 Europium Eu 63 Fermium Fm 100 Fluorine F...

  9. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    International Nuclear Information System (INIS)

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons

  10. SU-C-204-04: Patient Specific Proton Stopping Powers Estimation by Combining Proton Radiography and Prior-Knowledge X-Ray CT Information

    Energy Technology Data Exchange (ETDEWEB)

    Collins-Fekete, CA [Massachussetts General Hospital, Quebec, Quebec (Canada); Ion Beam Application, Louvain-la-neuve (Belgium); Aarhus University, Aarhus, Aarhus (Denmark); Centre Hospitalier Univ de Quebec, Quebec, QC (Canada); Brousmiche, S [Ion Beam Application, Louvain-la-neuve (Belgium); Hansen, D [Aarhus University, Aarhus, Aarhus (Denmark); Beaulieu, L [Centre Hospitalier Univ de Quebec, Quebec, QC (Canada); Seco, J [Mass General Hospital, Harvard Medical, Boston, MA (United States)

    2015-06-15

    Purpose: The material relative stopping power (RSP) uncertainty is the highest contributor to the range uncertainty in proton therapy. The purpose of this work is to develop a robust and systematic method that yields accurate, patient specific, RSP by combining 1) pre-treatment x-ray CT and 2) daily proton radiograph of the patient. Methods: The method is formulated as a linear least-square optimization problem (min||Ax-B||2). The parameter A represents the pathlength crossed by the proton in each material. The RSPs for the materials (water equivalent thickness (WET)/physical thickness) are denoted by x. B is the proton radiograph expressed as WET crossed. The problem is minimized using a convex-conic optimization algorithm with xi

  11. Precision mass measurements of some isotopes of tungsten and mercury for an adjustment to the mass table in the region A = 184 to A = 204

    Science.gov (United States)

    Barillari, Domenico K.

    This thesis concerns the precise re-measurement of mass values in the region of the mercury isotopes, such that important discrepancies in the high-mass end of the mass table could be resolved. Scope and contents. Four mass spectroscopic doublets involving a comparison between 201Hg, 199Hg and 183W (and using a chlorocarbon reference) are reported from measurements made with the upgraded Manitoba 11 deflection instrument. The measurements address the problem of a mass table mis-adjustment in the region of the valley of β-stability between the tungsten group and the noble metals. The results, forming a well-closed loop of mass differences, support the earlier results of Kozier [Ko(1977)] regarding the (stable) mercury isotope masses and confirm an approximate 20 μu discrepancy in the mass adjustment of Audi et al [Au(1993)]. A local least- square re-adjustment conducted using these and existing mass table data suggests that the error originates with mass differences pertaining to one or more other nuclide pairs, perhaps 193Ir-192Ir. The work on upgrading the precision voltage supply and potentiometry system of the Manitoba II instrument is also reported, as is a new assessment on the data processing method. (Abstract shortened by UMI.)

  12. 穴位注射配合麻黄汤辨证治疗强直性脊柱炎204

    Institute of Scientific and Technical Information of China (English)

    戴松铭

    2010-01-01

    @@ 强直性脊柱炎(ankylosing spondylitis,AS)是一种以中轴关节和肌腱、韧带、骨附着点的慢性炎症为主的全身性疾病,以炎性腰痛、肌腱端炎、外周关节炎和关节外表现为特点.

  13. SU-C-204-02: Improved Patient-Specific Optimization of the Stopping Power Calibration for Proton Therapy Planning Using a Single Proton Radiography

    Energy Technology Data Exchange (ETDEWEB)

    Rinaldi, I [Lyon 1 University and CNRS/IN2P3, UMR 5822, Villeurbanne (France); Ludwig Maximilian University, Garching, DE (Germany); Heidelberg University Hospital, Heidelberg, DE (Germany); Parodi, K [Ludwig Maximilian University, Garching, DE (Germany); Heidelberg University Hospital, Heidelberg, DE (Germany); Krah, N [Heidelberg Collaboratory for Image Processing, Heidelberg, DE (Germany)

    2015-06-15

    Purpose: We present an improved method to calculate patient-specific calibration curves to convert X-ray computed tomography (CT) Hounsfield Unit (HU) to relative stopping powers (RSP) for proton therapy treatment planning. Methods: By optimizing the HU-RSP calibration curve, the difference between a proton radiographic image and a digitally reconstructed X-ray radiography (DRR) is minimized. The feasibility of this approach has previously been demonstrated. This scenario assumes that all discrepancies between proton radiography and DRR originate from uncertainties in the HU-RSP curve. In reality, external factors cause imperfections in the proton radiography, such as misalignment compared to the DRR and unfaithful representation of geometric structures (“blurring”). We analyze these effects based on synthetic datasets of anthropomorphic phantoms and suggest an extended optimization scheme which explicitly accounts for these effects. Performance of the method is been tested for various simulated irradiation parameters. The ultimate purpose of the optimization is to minimize uncertainties in the HU-RSP calibration curve. We therefore suggest and perform a thorough statistical treatment to quantify the accuracy of the optimized HU-RSP curve. Results: We demonstrate that without extending the optimization scheme, spatial blurring (equivalent to FWHM=3mm convolution) in the proton radiographies can cause up to 10% deviation between the optimized and the ground truth HU-RSP calibration curve. Instead, results obtained with our extended method reach 1% or better correspondence. We have further calculated gamma index maps for different acceptance levels. With DTA=0.5mm and RD=0.5%, a passing ratio of 100% is obtained with the extended method, while an optimization neglecting effects of spatial blurring only reach ∼90%. Conclusion: Our contribution underlines the potential of a single proton radiography to generate a patient-specific calibration curve and to improve dose delivery by optimizing the HU-RSP calibration curve as long as all sources of systematic incongruence are properly modeled.

  14. SU-D-204-07: Comparison of AAPM TG150 Draft Image Receptor Tests with Vendor Automated QC Tests for Five Mobile DR Units

    Energy Technology Data Exchange (ETDEWEB)

    Li, G; Nishino, T [UT MD Anderson Cancer Center, Houston, TX (United States); Greene, T [Radiation Services, Inc., Dover, FL (United States); Willis, C [MD Anderson Cancer Center, Bellaire, TX (United States)

    2015-06-15

    Purpose: To determine the consistency of digital detector (DR) tests recommended by AAPM TG150 and tests provided by commercially available DirectView Total Quality Tool (TQT). Methods: The DR tests recommended by the TG150 Detector Subgroup[1] were performed on 4 new Carestream DRX-Revolution and one Carestream DRX1C retrofit of a GE AMX-4 that had been in service for three years. After detector calibration, flat-field images plus images of two bar patterns oriented parallel and perpendicular to the A-C axis, were acquired at conditions recommended by TG150. Raw images were harvested and then analyzed using a MATLAB software previously validated[2,3,4]. Data were analyzed using ROIs of two different dimensions: 1) 128 x 128 ROIs matching the detector electronics; and 2) 256 x 256 ROIs, each including 4 adjacent smaller ROIs. TG150 metrics from 128 x 128 ROIs were compared to TQT metrics, which are also obtained from 128 x 128 ROIs[5]. Results: The results show that both TG150 and TQT measurements were consistent among these detectors. Differences between TG150 and TQT values appear systematic. Compared with 128 x 128 ROIs, noise and SNR non-uniformity were lower with 256 x 256 ROIs, although signal non-uniformity was similar, indicating detectors were appropriately calibrated for gain and offset. MTF of the retrofit unit remained essentially the same between 2012 and 2015, but was inferior to the new units. The older generator focal spot is smaller (0.75mm vs. 1.2mm), and the SID for acquisition is 182cm as well, so focal spot dimensions cannot explain the difference. The difference in MTF may be secondary to differences in generator X-ray spectrum or by unannounced changes in detector architecture. Further investigation is needed. Conclusion: The study shows that both TG150 and TQT tests are consistent. The numerical value of some metrics are dependent on ROI size.

  15. CALiPER Report 20.4: Lumen and Chromaticity Maintenance of LED PAR38 Lamps Operated in Steady-State Conditions

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-12-30

    This CALiPER report focuses on lumen maintenance, chromaticity maintenance, and catastrophic failure in 32 of the Series 20 LED PAR38 lamps and 8 benchmark lamps, which were monitored for nearly 14,000 hours at ambient temperatures between 44°C and 45°C.

  16. SU-D-204-07: Comparison of AAPM TG150 Draft Image Receptor Tests with Vendor Automated QC Tests for Five Mobile DR Units

    International Nuclear Information System (INIS)

    Purpose: To determine the consistency of digital detector (DR) tests recommended by AAPM TG150 and tests provided by commercially available DirectView Total Quality Tool (TQT). Methods: The DR tests recommended by the TG150 Detector Subgroup[1] were performed on 4 new Carestream DRX-Revolution and one Carestream DRX1C retrofit of a GE AMX-4 that had been in service for three years. After detector calibration, flat-field images plus images of two bar patterns oriented parallel and perpendicular to the A-C axis, were acquired at conditions recommended by TG150. Raw images were harvested and then analyzed using a MATLAB software previously validated[2,3,4]. Data were analyzed using ROIs of two different dimensions: 1) 128 x 128 ROIs matching the detector electronics; and 2) 256 x 256 ROIs, each including 4 adjacent smaller ROIs. TG150 metrics from 128 x 128 ROIs were compared to TQT metrics, which are also obtained from 128 x 128 ROIs[5]. Results: The results show that both TG150 and TQT measurements were consistent among these detectors. Differences between TG150 and TQT values appear systematic. Compared with 128 x 128 ROIs, noise and SNR non-uniformity were lower with 256 x 256 ROIs, although signal non-uniformity was similar, indicating detectors were appropriately calibrated for gain and offset. MTF of the retrofit unit remained essentially the same between 2012 and 2015, but was inferior to the new units. The older generator focal spot is smaller (0.75mm vs. 1.2mm), and the SID for acquisition is 182cm as well, so focal spot dimensions cannot explain the difference. The difference in MTF may be secondary to differences in generator X-ray spectrum or by unannounced changes in detector architecture. Further investigation is needed. Conclusion: The study shows that both TG150 and TQT tests are consistent. The numerical value of some metrics are dependent on ROI size

  17. Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-Convergence on axonal guidance

    DEFF Research Database (Denmark)

    Kaalund, Sanne S; Venø, Morten T; Bak, Mads;

    2014-01-01

    OBJECTIVE: Mesial temporal lobe epilepsy (MTLE) is one of the most common types of the intractable epilepsies and is most often associated with hippocampal sclerosis (HS), which is characterized by pronounced loss of hippocampal pyramidal neurons. microRNAs (miRNAs) have been shown to be dysregul......OBJECTIVE: Mesial temporal lobe epilepsy (MTLE) is one of the most common types of the intractable epilepsies and is most often associated with hippocampal sclerosis (HS), which is characterized by pronounced loss of hippocampal pyramidal neurons. microRNAs (miRNAs) have been shown...... to be dysregulated in epilepsy and neurodegenerative diseases, and we hypothesized that miRNAs could be involved in the pathogenesis of MTLE and HS. METHODS: miRNA expression was quantified in hippocampal specimens from human patients using miRNA microarray and quantitative real-time polymerase chain reaction RT...

  18. In situ vaccination with CD204 gene-silenced dendritic cell, not unmodified dendritic cell, enhances radiation therapy of prostate cancer

    OpenAIRE

    Guo, Chunqing; Yi, Huanfa; YU, XIAOFEI; Zuo, Daming; Qian, Jie; Yang, Gary; Barbara A Foster; Subjeck, John R.; Sun, Xiaolei; Mikkelsen, Ross B.; Fisher, Paul B.; Wang, Xiang-Yang

    2012-01-01

    Given the complexity of prostate cancer progression and metastasis, multimodalities that target different aspects of tumor biology, e.g., radiotherapy (RT) in conjunction with immunotherapy, may provide the best opportunities for promoting clinical benefits in patients with high risk localized prostate cancer. Here we show that intratumoral administration of unmodified dendritic cells (DCs) failed to synergize with fractionated RT. However, ionizing radiation combined with in situ vaccination...

  19. TU-EF-204-01: Accurate Prediction of CT Tube Current Modulation: Estimating Tube Current Modulation Schemes for Voxelized Patient Models Used in Monte Carlo Simulations.

    OpenAIRE

    McMillan, K; Bostani, M; McCollough, C; McNitt-Gray, M

    2015-01-01

    PURPOSE: Most patient models used in Monte Carlo-based estimates of CT dose, including computational phantoms, do not have tube current modulation (TCM) data associated with them. While not a problem for fixed tube current simulations, this is a limitation when modeling the effects of TCM. Therefore, the purpose of this work was to develop and validate methods to estimate TCM schemes for any voxelized patient model. METHODS: For 10 patients who received clinically-indicated chest (n=5) and ab...

  20. Calculation notes that support accident scenario and consequence development for the leak from a railcar/tank trailer at the 204-ar waste unloading facility

    Energy Technology Data Exchange (ETDEWEB)

    Ryan, G.W., Westinghouse Hanford

    1996-09-19

    This document supports the development and presentation of the following accident scenario in the TWRS Final Safety Analysis Report: Leak from Railcar/Tank Trailer. The calculations needed to quantify the risk associated with this accident scenario are included within.

  1. 41 CFR 301-71.204 - Within how many calendar days after the submission of a proper travel claim must we reimburse the...

    Science.gov (United States)

    2010-07-01

    ... expenses; (f) Relocation income tax allowance; (g) Use of a relocation services company; (h) Home marketing... allowances are exempt from this provision: (a) Transportation and storage of household goods and...

  2. SU-D-204-06: Dose and Image Quality Evaluation of a Low-Dose Slot-Scanning X-Ray System for Pediatric Orthopedic Studies

    International Nuclear Information System (INIS)

    Purpose: Children in early teens with scoliosis require repeated radiographic exams over a number of years. The EOS (EOS imaging S.A., Paris, France) is a novel low-dose slot-scanning digital radiographic system designed to produce full-spine images of a free-standing patient. The radiation dose and image quality characteristics of the EOS were evaluated relative to those of a Computed Radiography (CR) system for scoliosis imaging. Methods: For dose evaluation, a full-torso anthropomorphic phantom was scanned five times using the default standard clinical protocols for both the EOS and a CR system, which include both posteroanterior and lateral full-spine views. Optically stimulated luminescent dosimeters (OSLDs), also known as nanoDots™ (Landauer, Inc., Glenwood, IL), were placed on the phantom’s surface to measure entrance skin dose. To assess image quality, MTF curves were generated from sampling the noise levels within the high-contrast regions of a line-pair phantom. Vertical and horizontal distortions were measured for the square line-pair phantom with the EOS system to evaluate the effects of geometric magnification and misalignment with the indicated imaging plane. Results: The entrance skin dose was measured to be 0.4 to 1.1 mGy for the EOS, and 0.7 to 3.6 mGy for the CR study. MTF comparison shows that CR greatly outperforms the EOS, despite both systems having a limiting resolution at 1.8 line-pairs per mm. Vertical distortion was unaffected by phantom positioning, because of the EOS slot-scanning geometry. Horizontal distortion increased linearly with miscentering distance. Conclusion: The EOS system resulted in approximately 70% lower radiation dose than CR for full-spine images. Image quality was found to be inferior to CR. Further investigation is required to see if EOS system is an acceptable modality for performing clinically diagnostic scoliosis examinations

  3. SU-C-204-04: Patient Specific Proton Stopping Powers Estimation by Combining Proton Radiography and Prior-Knowledge X-Ray CT Information

    International Nuclear Information System (INIS)

    Purpose: The material relative stopping power (RSP) uncertainty is the highest contributor to the range uncertainty in proton therapy. The purpose of this work is to develop a robust and systematic method that yields accurate, patient specific, RSP by combining 1) pre-treatment x-ray CT and 2) daily proton radiograph of the patient. Methods: The method is formulated as a linear least-square optimization problem (min||Ax-B||2). The parameter A represents the pathlength crossed by the proton in each material. The RSPs for the materials (water equivalent thickness (WET)/physical thickness) are denoted by x. B is the proton radiograph expressed as WET crossed. The problem is minimized using a convex-conic optimization algorithm with xi

  4. SU-D-204-06: Dose and Image Quality Evaluation of a Low-Dose Slot-Scanning X-Ray System for Pediatric Orthopedic Studies

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Z; Hoerner, M; Lamoureux, R; Rill, L; Arreola, M [Univ Florida, Jacksonville Beach, FL (United States)

    2015-06-15

    Purpose: Children in early teens with scoliosis require repeated radiographic exams over a number of years. The EOS (EOS imaging S.A., Paris, France) is a novel low-dose slot-scanning digital radiographic system designed to produce full-spine images of a free-standing patient. The radiation dose and image quality characteristics of the EOS were evaluated relative to those of a Computed Radiography (CR) system for scoliosis imaging. Methods: For dose evaluation, a full-torso anthropomorphic phantom was scanned five times using the default standard clinical protocols for both the EOS and a CR system, which include both posteroanterior and lateral full-spine views. Optically stimulated luminescent dosimeters (OSLDs), also known as nanoDots™ (Landauer, Inc., Glenwood, IL), were placed on the phantom’s surface to measure entrance skin dose. To assess image quality, MTF curves were generated from sampling the noise levels within the high-contrast regions of a line-pair phantom. Vertical and horizontal distortions were measured for the square line-pair phantom with the EOS system to evaluate the effects of geometric magnification and misalignment with the indicated imaging plane. Results: The entrance skin dose was measured to be 0.4 to 1.1 mGy for the EOS, and 0.7 to 3.6 mGy for the CR study. MTF comparison shows that CR greatly outperforms the EOS, despite both systems having a limiting resolution at 1.8 line-pairs per mm. Vertical distortion was unaffected by phantom positioning, because of the EOS slot-scanning geometry. Horizontal distortion increased linearly with miscentering distance. Conclusion: The EOS system resulted in approximately 70% lower radiation dose than CR for full-spine images. Image quality was found to be inferior to CR. Further investigation is required to see if EOS system is an acceptable modality for performing clinically diagnostic scoliosis examinations.

  5. 20 CFR 408.204 - What conditions will prevent you from qualifying for SVB or being entitled to receive SVB payments?

    Science.gov (United States)

    2010-04-01

    ... to section 237(a) or 212(a)(6)(A) of the Immigration and Nationality Act and before the month in... from which you fled, for a crime or an attempt to commit a crime that is a felony under the laws of...

  6. SU-E-J-204: Can a Commercial System for MR-IGRT Be Used to Treat Patients Without Acquiring a CT Scan?

    International Nuclear Information System (INIS)

    Patients treated using a magnetic-resonance image guided radiation therapy (MR-IGRT) system received both CT and MR simulations. During planning, the CT is used to determine relative electron density (RED) using a calibration table. This study aims to investigate the feasibility of MR-only treatments by comparing CT-computed dose distributions to those computed with combinations of water (1.0), lung (0.26), tissue (1.02), and bone (1.12) bulk RED overrides, and to identify the effects of the magnetic field on the RED-overridden doses. Methods: Four patients who received treatment using a commercial MR-IGRT system were analyzed (1 lung, 2 abdomen, and 1 pelvis). The clinical plans were computed using the first fraction MRI as primary, and the simulation CT as secondary for REDs. Plans were reoptimized using default bulk RED overrides (water/lung and tissue/lung for the lung patient, water/bone, tissue/bone, water only, and tissue only for the abdomen and pelvis patients). Additionally, each plan was re-optimized to include the static magnetic field. All plans were normalized to the same PTV coverage as the clinical plan. Dose-difference volumes and DVHs were computed for bulk density override plans, and 3D gamma analyses between each plan and its accompanying magnetic field plan were performed using 3%/3 mm dose difference and distance-to-agreement criteria using the PTV and Skin as masking structures. Results: The average differences in PTV and organs-at-risk mean dose for all RED combinations tested were −0.19 Gy (−0.62 – 0.06 Gy) and −0.34 Gy (−1.76 – 0.33 Gy), respectively. The average PTV and Skin gamma pass rates for all RED combinations tested were 99.88% (99.5% – 100%) and 98. 35% (96.3% – 99.6%). No systematic differences in DVHs or isodoses were observed. Conclusions: It is likely that that a commercial MR-IGRT system may produce high quality treatment plans without the need for CT scans. Authors of this abstract are members of the Washington University Radiation Oncology department, which has a research agreement with ViewRay, Inc

  7. SU-C-204-06: Surface Imaging for the Set-Up of Proton Post-Mastectomy Chestwall Irradiation: Gated Images Vs Non Gated Images

    International Nuclear Information System (INIS)

    Purpose: Historically, the set-up for proton post-mastectomy chestwall irradiation at our institution started with positioning the patient using tattoos and lasers. One or more rounds of orthogonal X-rays at gantry 0° and beamline X-ray at treatment gantry angle were then taken to finalize the set-up position. As chestwall targets are shallow and superficial, surface imaging is a promising tool for set-up and needs to be investigated Methods: The orthogonal imaging was entirely replaced by AlignRT™ (ART) images. The beamline X-Ray image is kept as a confirmation, based primarily on three opaque markers placed on skin surface instead of bony anatomy. In the first phase of the process, ART gated images were used to set-up the patient and the same specific point of the breathing curve was used every day. The moves (translations and rotations) computed for each point of the breathing curve during the first five fractions were analyzed for ten patients. During a second phase of the study, ART gated images were replaced by ART non-gated images combined with real-time monitoring. In both cases, ART images were acquired just before treatment to access the patient position compare to the non-gated CT. Results: The average difference between the maximum move and the minimum move depending on the chosen breathing curve point was less than 1.7 mm for all translations and less than 0.7° for all rotations. The average position discrepancy over the course of treatment obtained by ART non gated images combined to real-time monitoring taken before treatment to the planning CT were smaller than the average position discrepancy obtained using ART gated images. The X-Ray validation images show similar results with both ART imaging process. Conclusion: The use of ART non gated images combined with real time imaging allows positioning post-mastectomy chestwall patients in less than 3 mm / 1°

  8. SU-C-204-06: Surface Imaging for the Set-Up of Proton Post-Mastectomy Chestwall Irradiation: Gated Images Vs Non Gated Images

    Energy Technology Data Exchange (ETDEWEB)

    Batin, E; Depauw, N; MacDonald, S; Lu, H [Massachusetts General Hospital, Boston, MA (United States)

    2015-06-15

    Purpose: Historically, the set-up for proton post-mastectomy chestwall irradiation at our institution started with positioning the patient using tattoos and lasers. One or more rounds of orthogonal X-rays at gantry 0° and beamline X-ray at treatment gantry angle were then taken to finalize the set-up position. As chestwall targets are shallow and superficial, surface imaging is a promising tool for set-up and needs to be investigated Methods: The orthogonal imaging was entirely replaced by AlignRT™ (ART) images. The beamline X-Ray image is kept as a confirmation, based primarily on three opaque markers placed on skin surface instead of bony anatomy. In the first phase of the process, ART gated images were used to set-up the patient and the same specific point of the breathing curve was used every day. The moves (translations and rotations) computed for each point of the breathing curve during the first five fractions were analyzed for ten patients. During a second phase of the study, ART gated images were replaced by ART non-gated images combined with real-time monitoring. In both cases, ART images were acquired just before treatment to access the patient position compare to the non-gated CT. Results: The average difference between the maximum move and the minimum move depending on the chosen breathing curve point was less than 1.7 mm for all translations and less than 0.7° for all rotations. The average position discrepancy over the course of treatment obtained by ART non gated images combined to real-time monitoring taken before treatment to the planning CT were smaller than the average position discrepancy obtained using ART gated images. The X-Ray validation images show similar results with both ART imaging process. Conclusion: The use of ART non gated images combined with real time imaging allows positioning post-mastectomy chestwall patients in less than 3 mm / 1°.

  9. The afterglow of the short/intermediate-duration gamma-ray burst GRB 000301C: A jet at z=2.04

    DEFF Research Database (Denmark)

    Jensen, B.L.; Fynbo, J.U.; Gorosabel, J.;

    2001-01-01

    We present Ulysses and NEAR data from the detection of the short or intermediate duration (2 s) gamma-ray burst GRB 000301C (2000 March 1.41 UT). The gamma-ray burst (GRB) was localised by the Inter Planetary Network (IPN) and RXTE to an area of similar to 50 arcmin(2). A fading optical counterpart...

  10. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  11. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  12. Production cross section of At radionuclides from $^{7}$Li+$^{\\textrm{nat}}$Pb and $^{9}$Be+$^{\\textrm{nat}}$Tl reactions

    CERN Document Server

    Maiti, Moumita

    2011-01-01

    Earlier we reported theoretical studies on the probable production of astatine radionuclides from $^{6,7}$Li and $^{9}$Be-induced reactions on natural lead and thalliun targets, respectively. For the first time, in this report, production of astatine radionuclides has been investigated experimentally with two heavy ion induced reactions: $^{9}$Be+$^{\\textrm{nat}}$Tl and $^{7}$Li+$^{\\textrm{nat}}$Pb. Formation cross sections of the evaporation residues, $^{207,208,209,210}$At, produced in (HI, xn) channel, have been measured by the stacked-foil technique followed by the off-line $\\gamma$-spectrometry at the low incident energies ($<$50 MeV). Measured excitation functions have been explained in terms of compound nuclear reaction mechanism using Weisskopf-Ewing and Hauser-Feshbach model. Absolute cross section values are lower than the respective theoretical predictions.

  13. 40 CFR 63.4165 - How do I determine the emission capture system efficiency?

    Science.gov (United States)

    2010-07-01

    ... section are met: (1) The capture system meets the criteria in Method 204 of appendix M to 40 CFR part 51... building enclosure in Method 204 of appendix M to 40 CFR part 51. (2) Use Method 204A or 204F of appendix M to 40 CFR part 51 to determine the mass fraction of TVH liquid input from each coating, thinner,...

  14. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  15. 78 FR 80379 - Federal Acquisition Regulation; Trade Agreements Thresholds

    Science.gov (United States)

    2013-12-31

    ..., 2014. On December 18, 2013 (78 FR 76700), the United States Trade Representative published new...,000 204,000 10,335,931 Panama FTA 204,000 204,000 7,864,000 Peru FTA 204,000 204,000 7,864,000... changes are in line with inflation and maintain the status quo. List of Subjects in 48 CFR Parts 22,...

  16. 40 CFR 63.4964 - How do I determine the emission capture system efficiency?

    Science.gov (United States)

    2010-07-01

    ... coating operation during the capture efficiency test run. (4) Use Method 204D or E of appendix M to 40 CFR... Method 204 of appendix M to 40 CFR part 51 for a PTE and directs all the exhaust gases from the enclosure... 204 of appendix M to 40 CFR part 51. (2) Use Method 204A or 204F of appendix M to 40 CFR part 51...

  17. 40 CFR 63.4765 - How do I determine the emission capture system efficiency?

    Science.gov (United States)

    2010-07-01

    ... coating operation during the capture efficiency test run. (4) Use Method 204D or E of appendix M to 40 CFR... meets the criteria in Method 204 of appendix M to 40 CFR part 51 for a PTE and directs all the exhaust... enclosure in Method 204 of appendix M to 40 CFR part 51. (2) Use Method 204A or 204F of appendix M to 40...

  18. Luminescent Properties of Sm3+ Doped SrIn204 Red Emission Phosphor%SrIn2O4:Sm3+红色荧光粉的发光特性

    Institute of Scientific and Technical Information of China (English)

    刘海燕; 孙明生; 杨志平; 杨艳民

    2011-01-01

    The SrIn2O4: Sm3+ red emission phosphor were synthesized by combustion method and their lumi nescence properties were studied. The SrIn2O4: Sm3+ shows three major emission peaks at 568,606,660 nm,which correspond to the 4G5/2→6H5/2, 4G5/2→ 6H7/2 and 4G5/2→6H9/2 typical transition of Sm3+, respectively.The strongest emission peak is at 606 nm. Their excitation spectra containing two bands whose peaks located at 413,476 nm indicating that this phosphor can be excited effectively in both near-ultraviolet light-emitting diode (UVLED) and blue light-emitting diode for white LED. The influence of the concentration of Sm3 + was inves tigated also. The SrIn2O4: Sm3+ phosphor is a very appropriate red-emitting phosphor for white light-emitting diode device.%采用燃烧法合成了SrIn2O4:Sm3+红色荧光粉并研究了其发光性质.发射光谱由位于红橙区的3个主要荧光发射峰组成,峰值分别为568,606,660 nm,对应Sm3+的4G5/2→6H5/2、4G5/2→6H7/2和4G5/2→6H9/2特征跃迁发射,其中606 nm的发射最强.激发光谱包括峰值位于323,413 nm的宽带,说明该荧光粉可以被近紫外-紫色发光二极管管芯激发发射红光.研究了Sm3+的掺杂浓度对样品发光强度的影响.实验结果表明SrIn2O4:Sm3+是一种可用于制作白光LED的红色荧光粉.

  19. Multibeam collection for KN204-02: Multibeam data collected aboard Knorr from 2011-12-12 to 2011-12-23, departing from Praia, Cape Verde and returning to Woods Hole, MA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  20. Multibeam collection for KN204-01: Multibeam data collected aboard Knorr from 2011-11-06 to 2011-12-11, departing from Woods Hole, MA and returning to Praia, Cape Verde

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...