WorldWideScience

Sample records for astatine 203

  1. Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Jakobsson, U., E-mail: ulrjak@kth.se; Cederwall, B. [KTH, The Division of Nuclear Physics, AlbaNova University Center, SE-10691 Stockholm (Sweden); Uusitalo, J.; Auranen, K.; Badran, H.; Cox, D. M.; Grahn, T.; Greenlees, P. T.; Julin, R.; Juutinen, S.; Herzáň, A.; Konki, J.; Leino, M.; Mallaburn, M.; Pakarinen, J.; Papadakis, P.; Partanen, J.; Rahkila, P.; Sandzelius, M.; Sarén, J. [University of Jyvaskyla, Department of Physics, P.O. Box 35, FI-40014 University of Jyvaskyla (Finland); and others

    2015-10-15

    Low-lying states in neutron-deficient astatine and francium nuclei have been studied by means of in-beam and delayed spectroscopy. The 13/2{sup +} state has been observed in francium nuclei with a similar down-sloping trend as in neighbouring astatine and bismuth isotopes, as a function of decreasing neutron number. A systematic trend can also now be seen for the 1/2{sup +} state both in astatine and francium nuclei, where the level energy decreases steeply as a function of neutron number when moving further away from the neutron shell closure. This trend is very similar between astatine nuclei and their francium isotones. Moreover, shape coexistence has been observed between the 13/2{sup +} state and the spherical 9/2{sup −} ground state in {sup 203}Fr and {sup 205}Fr.

  2. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production.

  3. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  4. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom

    2015-01-01

    and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting......To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...

  5. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    NARCIS (Netherlands)

    Rothe, S.; Andreyev, A. N.; Antalic, S.; Borschevsky, A.; Capponi, L.; Cocolios, T. E.; De Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.; Kaldor, U.; Kudryavtsev, Yuri; Koester, U.; Lane, J. F. W.; Lassen, J.; Liberati, V.; Lynch, K. M.; Marsh, B. A.; Nishio, K.; Pauwels, D.; Pershina, V.; Popescu, L.; Procter, T. J.; Radulov, D.; Raeder, S.; Rajabali, M. M.; Rapisarda, E.; Rossel, R. E.; Sandhu, K.; Seliverstov, M. D.; Sjoedin, A. M.; Van den Bergh, P.; Van Duppen, P.; Venhart, M.; Wakabayashi, Y.; Wendt, K. D. A.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviou

  6. Main: HSRENTHSR203J [PLACE

    Lifescience Database Archive (English)

    Full Text Available HSRENTHSR203J S000466 24-April-2005 (last modified) kehi HSRE(HSR203 responsive ele...ment) in tobacco (N.t.) responsible for the marked induction of the HSR203J gene during the HR (hypersensiti...ve response); HSR203J is specifically activated during the early steps of incompatible plant/pathogen interactions; HR Nicotiana tabacum (tobacco) CAAAATTTTGTA ...

  7. Laser photodetachment of radioactive ions: towards the determination of the electronegativity of astatine

    CERN Multimedia

    Rothe, Sebastian; Welander, Jakob Emanuel; Chrysalidis, Katerina; Day Goodacre, Thomas; Fedosseev, Valentine; Fiotakis, Spyridon; Forstner, Oliver; Heinke, Reinhard Matthias; Johnston, Karl; Kron, Tobias; Koester, Ulli; Liu, Yuan; Marsh, Bruce; Ringvall Moberg, Annie; Rossel, Ralf Erik; Seiffert, Christoph; Studer, Dominik; Wendt, Klaus; Hanstorp, Dag

    2017-01-01

    Negatively charged ions are mainly stabilized through the electron correlation effect. A measure of the stability of a negative ion is the electron affinity, which the energy gain by attaching an electron to a neutral atom. This fundamental quantity is, due to the almost general lack of bound excited states, the only atomic property that can be determined with high accuracy for negative ions. We will present the results of the first laser photodetachment studies of radioactive negative ions at CERN-ISOLDE. The photodetachment threshold for the radiogenic iodine isotope 128I was measured successfully, demonstrating the performance of the upgraded GANDALPH experimental beam line. The first detection of photo-detached astatine atoms marks a milestone towards the determination of the EA of this radioactive element.

  8. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron affinity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photo-detachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral line width of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in off-line tests by the clear observation of the photo-detachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148.

  9. Ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and ionic radii of element Uus (Z = 117) and astatine.

    Science.gov (United States)

    Chang, Zhiwei; Li, Jiguang; Dong, Chenzhong

    2010-12-30

    Multiconfiguration Dirac-Fock (MCDF) method was employed to calculate the first five ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and radii for the element Uus and its homologue At. Main valence correlation effects were taken into account. The Breit interaction and QED effects were also estimated. The uncertainties of calculated IPs, EAs, and IR for Uus and At were reduced through an extrapolation procedure. The good consistency with available experimental and other theoretical values demonstrates the validity of the present results. These theoretical data therefore can be used to predict some unknown physicochemical properties of element Uus, Astatine, and their compounds.

  10. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  11. 40 CFR 240.203 - General design.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false General design. 240.203 Section 240.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR... design....

  12. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  13. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  14. 42 CFR 1002.203 - Mandatory exclusion.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Mandatory exclusion. 1002.203 Section 1002.203... AUTHORITIES PROGRAM INTEGRITY-STATE-INITIATED EXCLUSIONS FROM MEDICAID Mandatory Exclusion § 1002.203 Mandatory exclusion. (a) The State agency, in order to receive Federal financial participation (FFP),...

  15. 24 CFR 904.203 - Planning.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Planning. 904.203 Section 904.203... HOUSING HOMEOWNERSHIP OPPORTUNITIES Homeownership Counseling and Training § 904.203 Planning. (a) The... beyond the contract period. (c) In planning a homeownership counseling and training program, whether...

  16. 47 CFR 97.203 - Beacon station.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Beacon station. 97.203 Section 97.203... SERVICE Special Operations § 97.203 Beacon station. (a) Any amateur station licensed to a holder of a Technician, Technician Plus, General, Advanced or Amateur Extra Class operator license may be a beacon....

  17. 40 CFR 243.203 - Collection frequency.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Collection frequency. 243.203 Section 243.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES... and Recommended Procedures § 243.203 Collection frequency....

  18. 30 CFR 75.203 - Mining methods.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Mining methods. 75.203 Section 75.203 Mineral... SAFETY STANDARDS-UNDERGROUND COAL MINES Roof Support § 75.203 Mining methods. (a) The method of mining... faulty pillar recovery methods. Pillar dimensions shall be compatible with effective control of the...

  19. 14 CFR 25.203 - Stall characteristics.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Stall characteristics. 25.203 Section 25.203 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Stalls § 25.203 Stall characteristics. (a) It...

  20. 49 CFR 234.203 - Control circuits.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Control circuits. 234.203 Section 234.203 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION..., Inspection, and Testing Maintenance Standards § 234.203 Control circuits. All control circuits that...

  1. 33 CFR 136.203 - Proof.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Proof. 136.203 Section 136.203 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE POLLUTION... SOURCE; AND ADVERTISEMENT Procedures for Particular Claims § 136.203 Proof. In addition to...

  2. 49 CFR 37.203 - Lift maintenance.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Lift maintenance. 37.203 Section 37.203... DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.203 Lift maintenance. (a) The entity shall establish a system of regular and frequent maintenance checks of lifts sufficient to determine if they are...

  3. 34 CFR 685.203 - Loan limits.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Loan limits. 685.203 Section 685.203 Education..., DEPARTMENT OF EDUCATION WILLIAM D. FORD FEDERAL DIRECT LOAN PROGRAM Borrower Provisions § 685.203 Loan limits... Direct Stafford/Ford Loan Program and Federal Stafford Loan Program aggregate limits. The...

  4. 46 CFR 109.203 - Sanitation.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Sanitation. 109.203 Section 109.203 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS OPERATIONS Tests, Drills, and Inspections § 109.203 Sanitation. (a) The master or person in charge shall insure that the...

  5. 12 CFR 203.3 - Exempt institutions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Exempt institutions. 203.3 Section 203.3 Banks... DISCLOSURE (REGULATION C) § 203.3 Exempt institutions. (a) Exemption based on state law. (1) A state-chartered or state-licensed financial institution is exempt from the requirements of this regulation if...

  6. 1 CFR 20.3 - Organization.

    Science.gov (United States)

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Organization. 20.3 Section 20.3 General... DOCUMENTS HANDLING OF THE UNITED STATES GOVERNMENT MANUAL STATEMENTS § 20.3 Organization. (a) Information about lines of authority and organization may be reflected in a chart if the chart clearly...

  7. 7 CFR 1260.203 - Confidential treatment.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1260.203 Section 1260.203 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING... Promotion and Research Order Reports, Books and Records § 1260.203 Confidential treatment. All...

  8. 29 CFR 1614.203 - Rehabilitation Act.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Rehabilitation Act. 1614.203 Section 1614.203 Labor... EMPLOYMENT OPPORTUNITY Provisions Applicable to Particular Complaints § 1614.203 Rehabilitation Act. (a... Rehabilitation Act of 1973, as amended (29 U.S.C. 791), has been violated in a complaint alleging...

  9. 42 CFR 56.203 - Project elements.

    Science.gov (United States)

    2010-10-01

    ... SERVICES Grants for Planning and Developing Migrant Health Centers § 56.203 Project elements. A project for... population, based on the assessment prepared pursuant to paragraph (b) of this section which indicates in... 42 Public Health 1 2010-10-01 2010-10-01 false Project elements. 56.203 Section 56.203...

  10. 42 CFR 51c.203 - Project elements.

    Science.gov (United States)

    2010-10-01

    ... SERVICES Grants for Planning and Developing Community Health Centers § 51c.203 Project elements. A project... fulfill the needs identified in the assessment prepared pursuant to paragraph (a) of this section and how... 42 Public Health 1 2010-10-01 2010-10-01 false Project elements. 51c.203 Section 51c.203...

  11. 24 CFR 203.7 - Commitment process.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Commitment process. 203.7 Section 203.7 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Insurance, and Commitments § 203.7 Commitment process. For single family mortgage programs that are...

  12. 34 CFR 682.203 - Responsible parties.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Responsible parties. 682.203 Section 682.203 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM General Provisions § 682.203...

  13. 48 CFR 203.1004 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct 203.1004 Contract clauses. (a) Use the clause at 252.203-7003 in solicitations and contracts that include the FAR clause 52.203-13, Contractor Code of Business Ethics and...

  14. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  15. Dicty_cDB: AFG203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AF (Link to library) AFG203 (Link to dictyBase) - - - Contig-U16382-1 AFG203E (Link to Original site) AFG20...3F 611 AFG203Z 741 AFG203P 1352 AFG203E 1195 Show AFG203 Library AF (Link to library) Clone ID AFG20...ginal site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/AF/AFG2-A/AFG203Q.Seq.d/ Re...presentative seq. ID AFG203E (Link to Original site) Representative DNA sequence >AFG203 (AFG203Q) /CSM/AF/AFG2-A/AFG20...SM-cDNA Score E Sequences producing significant alignments: (bits) Value AFG203 (AFG203Q) /CSM/AF/AFG2-A/AFG20

  16. 48 CFR 203.1003 - Requirements.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct 203.1003 Requirements. (b) Notification of possible contractor violation....

  17. 40 CFR 203.1 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Definitions. 203.1 Section 203.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS LOW-NOISE... meaning given it in the Noise Control Act of 1972 (Pub. L. 92-574). (1) Act means the Noise Control Act...

  18. 14 CFR 67.203 - Eye.

    Science.gov (United States)

    2010-01-01

    ... separately, with or without corrective lenses. If corrective lenses (spectacles or contact lenses) are... equivalent, at 16 inches in each eye separately, with or without corrective lenses. If age 50 or older, near... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Eye. 67.203 Section 67.203 Aeronautics...

  19. 12 CFR 203.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Definitions. 203.2 Section 203.2 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM HOME MORTGAGE DISCLOSURE... of Puerto Rico. The term includes an individual condominium unit, cooperative unit, or mobile...

  20. 32 CFR 203.13 - Procurement.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Procurement. 203.13 Section 203.13 National....13 Procurement. Procurements will be conducted as purchase orders in accordance with the FAR (48 CFR part 13). Under these procedures, procurements not exceeding $100,000 are reserved exclusively...

  1. 24 CFR 945.203 - Allocation plan.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Allocation plan. 945.203 Section... FAMILIES Application and Approval Procedures § 945.203 Allocation plan. (a) Applicable terminology. (1) As used in this section, the terms “initial allocation plan” refers to the PHA's first submission of...

  2. 48 CFR 570.203-2 - Competition.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Competition. 570.203-2... 570.203-2 Competition. (a) Solicit at least three sources to promote competition to the maximum extent practicable. If you have repeated requirements for space in the same market, and if practicable, invite...

  3. 5 CFR 844.203 - Supporting documentation.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Supporting documentation. 844.203 Section... § 844.203 Supporting documentation. (a) An individual or agency filing an application for disability... whatever documentation OPM requires in order to determine whether the individual meets the...

  4. 23 CFR 230.203 - Policy.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Policy. 230.203 Section 230.203 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS EXTERNAL PROGRAMS Supportive Services for Minority... participation of minority business enterprises in Federal-aid highway contracts in part through the...

  5. 7 CFR 1726.203 - Multiparty negotiation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Multiparty negotiation. 1726.203 Section 1726.203... negotiation. Multiparty negotiation may only be used where permitted under subpart F of this part or where... negotiation: (a) Selection of qualified bidders. The borrower (acting through its engineer, if...

  6. 42 CFR 93.203 - Complainant.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Complainant. 93.203 Section 93.203 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  7. 41 CFR 50-203.11 - Review.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Review. 50-203.11 Section...-Healey Public Contracts Act § 50-203.11 Review. (a) Within twenty (20) days after service of the decision... administrative law judge an original and four copies of a petition for review of the decision. The petition...

  8. 37 CFR 203.3 - Organization.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Organization. 203.3 Section... PROCEDURES FREEDOM OF INFORMATION ACT: POLICIES AND PROCEDURES Organization § 203.3 Organization. (a) In... legislative and policy matters. (e) The Office has no field organization. (f) The Office is located in...

  9. 48 CFR 2944.203 - Consent limitations.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Consent limitations. 2944.203 Section 2944.203 Federal Acquisition Regulations System DEPARTMENT OF LABOR CONTRACT MANAGEMENT... rationale), signed by the contracting officer, and included in the contract file....

  10. 24 CFR 203.672 - Residential areas.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Residential areas. 203.672 Section... FAMILY MORTGAGE INSURANCE Servicing Responsibilities Occupied Conveyance § 203.672 Residential areas. (a) For the purposes of occupied conveyance considerations, a residential area is any area...

  11. 12 CFR 268.203 - Rehabilitation Act.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Rehabilitation Act. 268.203 Section 268.203... Rehabilitation Act. (a) Model employer. The Board shall be a model employer of individuals with disabilities. The... Rehabilitation Act of 1973, as amended (29 U.S.C. 791), has been violated in a complaint alleging...

  12. 32 CFR 203.19 - Appeals process.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Appeals process. 203.19 Section 203.19 National....19 Appeals process. DoD Components will establish an appeals process to settle potential disputes... process. The Department of Defense recognizes that the RAB/TRC may disagree with the findings of...

  13. 32 CFR 203.5 - TAPP process.

    Science.gov (United States)

    2010-07-01

    ... to follow the rules and regulations for purchase orders as outlined in the FAR (48 CFR part 13). As a... 32 National Defense 2 2010-07-01 2010-07-01 false TAPP process. 203.5 Section 203.5 National... TAPP process. This section provides an overview of the TAPP process. Specific details referred to...

  14. 18 CFR 375.203 - Open meetings.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Open meetings. 375.203... § 375.203 Open meetings. (a) General rule. Except as provided in § 375.206, meetings of the Commission will be open meetings. (b) Public participation in open meetings. (1) Members of the public are...

  15. 32 CFR 203.6 - Cost principles.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Cost principles. 203.6 Section 203.6 National... Cost principles. (a) Non-profit contractors must comply with the cost principles in OMB Circular A-122...) For-profit contractors and subcontractors must comply with the cost principles in the FAR (48 CFR...

  16. 5 CFR 2606.203 - Granting access.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Granting access. 2606.203 Section 2606... Access to Records and Accounting of Disclosures § 2606.203 Granting access. (a) The methods for allowing access to records, when such access has been granted by OGE or the other agency concerned are:...

  17. 27 CFR 24.203 - Honey wine.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Honey wine. 24.203 Section... THE TREASURY LIQUORS WINE Production of Agricultural Wine § 24.203 Honey wine. (a) Subject to paragraph (b) of this section, a winemaker, in the production of wine from honey, may add the following:...

  18. 28 CFR 42.203 - Discrimination prohibited.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Discrimination prohibited. 42.203 Section...) of the Justice System Improvement Act of 1979 § 42.203 Discrimination prohibited. (a) No person in... participation in, be denied the benefits of, be subjected to discrimination under, or denied employment...

  19. 40 CFR 86.203-94 - Abbreviations.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Abbreviations. 86.203-94 Section 86.203-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... Later Model Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New...

  20. 48 CFR 2424.203 - Policy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. 2424.203 Section 2424.203 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT... Policy. See 24 CFR part 15 for the HUD regulations which implement the Freedom of Information Act....

  1. 5 CFR 179.203 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Definitions. 179.203 Section 179.203 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS.... Hearing official means an individual (including an administrative law judge) responsible for...

  2. Dicty_cDB: SLI203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLI203 (Link to dictyBase) - - - Contig-U16463-1 SLI203Z (Link... to Original site) - - SLI203Z 579 - - - - Show SLI203 Library SL (Link to library) Clone ID SLI203 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLI2-A/SLI203Q.Seq.d/ Representative seq. ID SLI20...3Z (Link to Original site) Representative DNA sequence >SLI203 (SLI203Q) /CSM/SL/SLI2-A/SLI203Q.Seq.d/ XXXXX...VNDVIKFAARSNL*ini lkiikk*knkkk*ki Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SLI203 (SLI2

  3. Dicty_cDB: SFC203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SF (Link to library) SFC203 (Link to dictyBase) - - - Contig-U16289-1 SFC203P (Link to Original site) SFC...203F 151 SFC203Z 340 SFC203P 491 - - Show SFC203 Library SF (Link to library) Clone ID SFC... URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SF/SFC2-A/SFC203Q.Seq.d/ Representative seq. ID SFC...203P (Link to Original site) Representative DNA sequence >SFC203 (SFC203Q) /CSM/SF/SFC2-A/SFC2...fnvvrsrry*tmatitkrcrlvirk*shcrv*tcqws*p Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SFC

  4. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  5. 48 CFR 828.203 - Acceptability of individual sureties.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acceptability of individual sureties. 828.203 Section 828.203 Federal Acquisition Regulations System DEPARTMENT OF VETERANS... Acceptability of individual sureties....

  6. Dicty_cDB: CHS203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHS203 (Link to dictyBase) - - - Contig-U11332-1 - (Link to Or...iginal site) - - CHS203Z 727 - - - - Show CHS203 Library CH (Link to library) Clone ID CHS203 (Link to dicty...Base) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U11332-1 Original site URL http://dictycdb.b...LSYDILSLLDS HLWLKKPLTISPQFLTMIGPELDPTLPNNPFKEFFNKLGTSSHDSGDNIDFKIPSFFEDN SRRHWGVETELSTGSCPICTLSLAENPESSFLGST...SYDILSLLDS HLWLKKPLTISPQFLTMIGPELDPTLPNNPFKEFFNKLGTSSHDSGDNIDFKIPSFFEDN SRRHWGVETELSTGSCPICTLSLAENPESSFLGSTP

  7. 31 CFR 203.10 - Electronic payment methods.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Electronic payment methods. 203.10 Section 203.10 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... TAX AND LOAN PROGRAM Electronic Federal Tax Payments § 203.10 Electronic payment methods. (a)...

  8. 31 CFR 203.9 - Scope of the subpart.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Scope of the subpart. 203.9 Section 203.9 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... LOAN PROGRAM Electronic Federal Tax Payments § 203.9 Scope of the subpart. This subpart prescribes...

  9. 31 CFR 203.12 - EFTPS interest assessments.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false EFTPS interest assessments. 203.12 Section 203.12 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... TAX AND LOAN PROGRAM Electronic Federal Tax Payments § 203.12 EFTPS interest assessments....

  10. 31 CFR 203.13 - Appeal and dispute resolution.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Appeal and dispute resolution. 203.13 Section 203.13 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... TAX AND LOAN PROGRAM Electronic Federal Tax Payments § 203.13 Appeal and dispute resolution....

  11. 48 CFR 9.203 - QPL's, QML's, and QBL's.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false QPL's, QML's, and QBL's. 9.203 Section 9.203 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Qualifications Requirements 9.203 QPL's, QML's, and QBL's....

  12. 46 CFR 108.203 - Berths and lockers.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Berths and lockers. 108.203 Section 108.203 Shipping... EQUIPMENT Construction and Arrangement Accommodation Spaces § 108.203 Berths and lockers. (a) Each sleeping...) Each occupant of a sleeping space must have a readily accessible locker of hard, smooth material....

  13. 24 CFR 203.18a - Solar energy system.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Solar energy system. 203.18a... § 203.18a Solar energy system. (a) The dollar limitation provided in § 203.18(a) may be increased by up... to the installation of a solar energy system. (b) Solar energy system is defined as any...

  14. 48 CFR 1815.203-72 - Risk management.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Risk management. 1815.203-72 Section 1815.203-72 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... Proposals and Information 1815.203-72 Risk management. In all RFPs and RFOs for supplies or services...

  15. 48 CFR 1329.203-70 - DOC Federal tax exemption.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false DOC Federal tax exemption. 1329.203-70 Section 1329.203-70 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS TAXES Federal Excise Taxes 1329.203-70 DOC Federal tax exemption. (a) The Office...

  16. 48 CFR 29.203 - Other Federal tax exemptions.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Other Federal tax exemptions. 29.203 Section 29.203 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS TAXES Federal Excise Taxes 29.203 Other Federal tax exemptions....

  17. 48 CFR 1329.203 - Other Federal tax exemptions.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Other Federal tax exemptions. 1329.203 Section 1329.203 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS TAXES Federal Excise Taxes 1329.203 Other Federal tax exemptions....

  18. 24 CFR 203.37 - Nature of title to realty.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Nature of title to realty. 203.37 Section 203.37 Housing and Urban Development Regulations Relating to Housing and Urban Development... § 203.37 Nature of title to realty. A mortgage, to be eligible for insurance, must be on real...

  19. 5 CFR 410.203 - Options for developing employees.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Options for developing employees. 410.203 Section 410.203 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS TRAINING Planning and Evaluating Training § 410.203 Options for developing employees. Agencies may use a full...

  20. 42 CFR 400.203 - Definitions specific to Medicaid.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Definitions specific to Medicaid. 400.203 Section 400.203 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS INTRODUCTION; DEFINITIONS Definitions § 400.203 Definitions specific...

  1. 20 CFR 416.203 - Initial determinations of SSI eligibility.

    Science.gov (United States)

    2010-04-01

    .... 416.203 Section 416.203 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility General § 416.203 Initial determinations of SSI... for documents and any other information we need to make sure you meet all the requirements. We...

  2. 5 CFR 2610.203 - Documentation of fees and expenses.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Documentation of fees and expenses. 2610.203 Section 2610.203 Administrative Personnel OFFICE OF GOVERNMENT ETHICS ORGANIZATION AND PROCEDURES IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 2610.203...

  3. 49 CFR 238.203 - Static end strength.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Static end strength. 238.203 Section 238.203... Equipment § 238.203 Static end strength. (a)(1) Except as further specified in this paragraph or in.... (2) For a passenger car or a locomotive, the static end strength of unoccupied volumes may be...

  4. 48 CFR 570.203-1 - Market survey.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Market survey. 570.203-1 Section 570.203-1 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SPECIAL... 570.203-1 Market survey. Conduct a market survey to identify potential sources. Use...

  5. 41 CFR 50-203.12 - Effective date.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Effective date. 50-203.12 Section 50-203.12 Public Contracts and Property Management Other Provisions Relating to Public Contracts...-Healey Public Contracts Act § 50-203.12 Effective date. The amendments to Subpart A shall...

  6. 42 CFR 84.203 - Breathing resistance test; minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Breathing resistance test; minimum requirements. 84.203 Section 84.203 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Chemical Cartridge Respirators § 84.203 Breathing resistance test; minimum requirements. (a) Resistance...

  7. 7 CFR 765.203 - Protective advances.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE SPECIAL PROGRAMS DIRECT LOAN SERVICING-REGULAR Protecting the Agency's Security Interest § 765.203 Protective advances. When necessary to protect the Agency's security interest, costs incurred for the..., hazard, or flood insurance; (e) Pay harvesting costs; (f) Maintain Agency security instruments; (g)...

  8. 48 CFR 50.203 - General.

    Science.gov (United States)

    2010-10-01

    ... that will enhance the protection of the nation; and (2) Provide risk management and litigation management protections for sellers of QATTs and others in the supply and distribution chain. (b) The SAFETY....203 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT...

  9. 21 CFR 131.203 - Lowfat yogurt.

    Science.gov (United States)

    2010-04-01

    .... (d) Other optional ingredients. (1) Concentrated skim milk, nonfat dry milk, buttermilk, whey... CONSUMPTION MILK AND CREAM Requirements for Specific Standardized Milk and Cream § 131.203 Lowfat yogurt. (a... than 8.25 percent milk solids not fat, and has a titratable acidity of not less than 0.9...

  10. 48 CFR 11.203 - Customer satisfaction.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Customer satisfaction. 11... PLANNING DESCRIBING AGENCY NEEDS Using and Maintaining Requirements Documents 11.203 Customer satisfaction. Acquisition organizations shall communicate with customers to determine how well the requirements...

  11. 15 CFR 970.203 - Exploration plan.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Exploration plan. 970.203 Section 970... Exploration plan. (a) General. Each application must include an exploration plan which describes the applicant.... Generally, the exploration plan must demonstrate to a reasonable extent that the applicant's efforts, by...

  12. 33 CFR 203.13 - Available assistance.

    Science.gov (United States)

    2010-07-01

    ... Secretary of the Army or his delegated nominee) to construct wells and to transport water for human... Section 203.13 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE EMERGENCY EMPLOYMENT OF ARMY AND OTHER RESOURCES, NATURAL DISASTER PROCEDURES Introduction §...

  13. Tank 241-C-203: Tank characterization plan

    Energy Technology Data Exchange (ETDEWEB)

    Schreiber, R.D.

    1995-03-06

    This document is a plan which serves as the contractual agreement between the Characterization Program, Sampling Operations, and WHC 222-S Laboratory. Scope of this plan is to provide guidance for sampling and analysis of samples for tank 241-C-203.

  14. 5 CFR 430.203 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... Performance Appraisal for General Schedule, Prevailing Rate, and Certain Other Employees § 430.203 Definitions... plans, and other means of expressing expected performance. Appraisal means the process under which performance is reviewed and evaluated. Appraisal period means the established period of time for...

  15. 33 CFR 203.46 - Restrictions.

    Science.gov (United States)

    2010-07-01

    ... Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program § 203.46 Restrictions. (a) Restrictions to flood control works. Flood control works are designed and...) Non-flood related rehabilitation. Rehabilitation of flood control structures damaged by...

  16. 40 CFR 156.203 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.203 Definitions. Terms in this subpart have the same meanings as they do in the Federal Insecticide, Fungicide, and Rodenticide Act,...

  17. 47 CFR 13.203 - Examination elements.

    Science.gov (United States)

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS Examination System § 13.203... commercial radio operator license. For each Element, the Commission shall establish through public notices or... operation of pertinent GMDSS sub-systems and equipment; ability to send and receive correctly by...

  18. 21 CFR 203.3 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... PRESCRIPTION DRUG MARKETING General Provisions § 203.3 Definitions. (a) The act means the Federal Food, Drug..., data, audio, pictorial, or other information representation in digital form that is created, modified... same marketing or service area, or nearby licensed practitioners, of drugs for use in the treatment...

  19. Proposition 203: A Critical Metaphor Analysis

    Science.gov (United States)

    Johnson, Eric

    2005-01-01

    This project draws on Lakoff and Johnson's (1980) work with metaphor analysis to uncover the rhetorical strategies applied by supporters of the English for the Children organization during the 2000 Arizona Proposition 203 campaign. The data were collected from three sources: (a) "The Arizona Republic"; (b) the "East Valley Tribune"; and (c) the…

  20. 43 CFR 17.203 - Discrimination prohibited.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Discrimination prohibited. 17.203 Section... Discrimination prohibited. (a) General. No qualified handicapped person shall, on the basis of handicap, be excluded from participation in, be denied the benefits of, or otherwise be subjected to...

  1. 7 CFR 1219.203 - Reapportionment of membership.

    Science.gov (United States)

    2010-01-01

    ... SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HASS AVOCADO PROMOTION, RESEARCH, AND INFORMATION Rules and Regulations § 1219.203 Reapportionment...

  2. 49 CFR 384.203 - Driving while under the influence.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Driving while under the influence. 384.203 Section... § 384.203 Driving while under the influence. (a) The State must have in effect and enforce through... apply its criminal or other sanctions for driving under the influence to a person found to have...

  3. 48 CFR 352.203-70 - Anti-lobbying.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Anti-lobbying. 352.203-70... SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions and Clauses 352.203-70 Anti-lobbying. As prescribed in 303.808-70, the Contracting Officer shall insert the following clause: Anti-Lobbying...

  4. 5 CFR 950.203 - Public accountability standards.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Public accountability standards. 950.203... PRIVATE VOLUNTARY ORGANIZATIONS Eligibility Provisions § 950.203 Public accountability standards. (a) To... comply with the requirements of public accountability, and the charitable organization may be...

  5. 41 CFR 109-38.203 - Agency identification.

    Science.gov (United States)

    2010-07-01

    ... Administrative Services, Logistics Management Division, Headquarters, using DOE Form 4250.2, “Requisition for... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Agency identification. 109-38.203 Section 109-38.203 Public Contracts and Property Management Federal Property...

  6. 41 CFR 105-54.203-2 - Active charters file.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Active charters file. 105-54.203-2 Section 105-54.203-2 Public Contracts and Property Management Federal Property Management... charters file. The GSA Committee Management Officer retains each original signed charter in a file...

  7. 48 CFR 1519.203 - Mentor-protege.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Mentor-protege. 1519.203... PROGRAMS SMALL BUSINESS PROGRAMS Policies 1519.203 Mentor-protege. (a) The Contracting officer shall insert the clause at 1552.219-70, Mentor-Protege Program, in all contracts under which the Contractor...

  8. 31 CFR 539.203 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 539.203 Section 539.203 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY WEAPONS OF MASS DESTRUCTION TRADE...

  9. 14 CFR 139.203 - Contents of Airport Certification Manual.

    Science.gov (United States)

    2010-01-01

    .... 139.203 Section 139.203 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... are significant to emergency operations X X X X 5. The location of each obstruction required to be..., equipment, personnel, and procedures for meeting the aircraft rescue and firefighting requirements,...

  10. 48 CFR 1328.203-7 - Exclusion of individual sureties.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Exclusion of individual sureties. 1328.203-7 Section 1328.203-7 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE... Exclusion of individual sureties. The designee authorized to exclude an individual from acting as a...

  11. 48 CFR 1328.203 - Acceptability of individual sureties.

    Science.gov (United States)

    2010-10-01

    ... individual sureties. 1328.203 Section 1328.203 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE... Acceptability of individual sureties. (a) Contracting officers shall obtain the opinion of the Procurement Counsel as to the adequacy of the documents pledging the assets of an individual surety prior to...

  12. 46 CFR 16.203 - Employer, MRO, and SAP responsibilities.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Employer, MRO, and SAP responsibilities. 16.203 Section... CHEMICAL TESTING Required Chemical Testing § 16.203 Employer, MRO, and SAP responsibilities. (a) Employers...) Substance Abuse Professional (SAP). Individuals performing SAP functions must meet the training...

  13. 10 CFR 63.203 - Implementation of Subpart K.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Implementation of Subpart K. 63.203 Section 63.203 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC... Implementation of Subpart K. DOE must demonstrate that normal operations at the Yucca Mountain site will and...

  14. 24 CFR 203.434 - Declaration of trust.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Declaration of trust. 203.434... Mortgage § 203.434 Declaration of trust. A sale of a beneficial interest in a group of insured mortgages... interest in a specific mortgage shall be made only pursuant to a declaration of trust, which has...

  15. 31 CFR 29.203 - Service of Process.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Service of Process. 29.203 Section 29.203 Money and Finance: Treasury Office of the Secretary of the Treasury FEDERAL BENEFIT PAYMENTS UNDER CERTAIN DISTRICT OF COLUMBIA RETIREMENT PROGRAMS Coordination With the District Government §...

  16. 33 CFR 203.51 - Levee owner's manual.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Levee owner's manual. 203.51... Program § 203.51 Levee owner's manual. (a) Authority. In accordance with section 202(f) of Public Law 104-303, the Corps will provide a levee owner's manual to the non-Federal sponsor of all flood...

  17. 48 CFR 1505.203 - Publicizing and response time.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Publicizing and response time. 1505.203 Section 1505.203 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY... in FAR 5.202(a)(7), if to do so would disclose the originality of thought or innovativeness of...

  18. 49 CFR 1580.203 - Reporting significant security concerns.

    Science.gov (United States)

    2010-10-01

    ..., Scenic, Historic and Excursion Operators, and Private Cars § 1580.203 Reporting significant security... 49 Transportation 9 2010-10-01 2010-10-01 false Reporting significant security concerns. 1580.203... SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY MARITIME AND LAND TRANSPORTATION SECURITY...

  19. 14 CFR 221.203 - Unique rule numbers required.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Unique rule numbers required. 221.203... PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Electronically Filed Tariffs § 221.203 Unique rule numbers required... bear a unique rule number. (b) The unique rule numbers for the fares specified in this section shall...

  20. 29 CFR 1952.203 - Compliance staffing benchmarks.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Compliance staffing benchmarks. 1952.203 Section 1952.203... Compliance staffing benchmarks. Under the terms of the 1978 Court Order in AFL-CIO v. Marshall, compliance staffing levels (benchmarks) necessary for a “fully effective” enforcement program were required to...

  1. 49 CFR 571.203 - Standard No. 203; Impact protection for the driver from the steering control system.

    Science.gov (United States)

    2010-10-01

    ... MOTOR VEHICLE SAFETY STANDARDS Federal Motor Vehicle Safety Standards § 571.203 Standard No. 203; Impact... a result of impact. S2. Application. This standard applies to passenger cars and to multipurpose... impact. S4. Requirements. Each passenger car and each multipurpose passenger vehicle, truck and bus...

  2. An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211

    Energy Technology Data Exchange (ETDEWEB)

    O’Hara, Matthew J.; Krzysko, Anthony J.; Niver, Cynthia M.; Morrison, Samuel S.; Owsley, Stanley L.; Hamlin, Donald K.; Dorman, Eric F.; Scott Wilbur, D.

    2017-04-01

    Astatine-211 (211At) is a promising cyclotron-produced radionuclide being investigated for use in targeted alpha therapy of blood borne and metastatic cancers, as well as treatment of tumor remnants after surgical resections. The isolation of trace quantities of 211At, produced within several grams of a Bi metal cyclotron target, involves a complex, multi-step procedure: (1) Bi metal dissolution in strong HNO3, (2) distillation of the HNO3 to yield Bi salts containing 211At, (3) dissolution of the salts in strong HCl, (4) solvent extraction of 211At from bismuth salts with diisopropyl ether (DIPE), and (5) back-extraction of 211At from DIPE into NaOH, leading to a purified 211At product. Step (1) has been addressed first to begin the process of automating the onerous 211At isolation process. A computer-controlled Bi target dissolution system has been designed. The system performs in-line dissolution of Bi metal from the target assembly using an enclosed target dissolution block, routing the resulting solubilized 211At/Bi mixture to the subsequent process step. The primary parameters involved in Bi metal solubilization (HNO3 concentration and influent flow rate) were optimized prior to evaluation of the system performance on replicate cyclotron irradiated targets. The results indicate that the system performs reproducibly, having nearly quantitative release of 211At from irradiated targets, with cumulative 211At recoveries that follow a sigmoidal function. The predictable nature of the 211At release profile allows the user to tune the system to meet target processing requirements.

  3. Evaluation of oxime k203 as antidote in tabun poisoning.

    Science.gov (United States)

    Kovarik, Zrinka; Vrdoljak, Ana Lucić; Berend, Suzana; Katalinić, Maja; Kuc, Kamil; Musilek, Kamil; Radić, Bozica

    2009-03-01

    We studied bispyridinium oxime K203 [(E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide] with tabun-inhibited human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro, and its antidotal effect on tabun-poisoned mice and rats in vivo. We compared it with oximes K048 and TMB-4, which have proven the most efficient oxime antidotes in tabun poisoning by now. Tabun-inhibited AChE was completely reactivated by K203, with the overall reactivation rate constant of 1806 L mol(-1) min(-1). This means that K203 is a very potent reactivator of tabun-inhibited AChE. In addition, K203 reversibly inhibited AChE (Ki = 0.090 mmol L(-1)) and BChE (K(i) = 0.91 mmol L(-1)), and exhibited its protective effect against phosphorylation of AChE by tabun in vitro. In vivo, a quarter of the LD50 K203 dose insured survival of all mice after the application of as many as 8 LD50 doses of tabun, which is the highest dosage obtained compared to K048 and TMB-4. Moreover, K203 showed high therapeutic potency in tabun-poisoned rats, preserving cholinesterase activity in rat plasma up to 60 min after poisoning. This therapeutic improvement obtained by K203 in tabun-poisoning places this oxime in the spotlight for further development.

  4. Equilibrium and pre-equilibrium emissions in proton-induced reactions on 203,205Tl

    Indian Academy of Sciences (India)

    A Kaplan; A Aydin; E Tel; B Şarer

    2009-02-01

    In this study, the excitation functions for the reactions 203Tl(, )203Pb, 203Tl(, 3)203Pb, 203Tl(, 2)202Pb, 205Tl(, 4)202Pb, 203Tl(, 3)201Pb, 205Tl(, 5)201Pb, 203Tl(, 4)200Pb and 205Tl(, 6)200Pb have been calculated using pre-equilibrium and equilibrium reaction mechanisms. Calculated results based on hybrid model, geometry-dependent hybrid model and cascade-exciton model have been compared with the experimental data.

  5. 48 CFR 1631.203-72 - Home office expense.

    Science.gov (United States)

    2010-10-01

    ... for purposes of FAR 31.203 if they are allocated on the basis of the beneficial or causal relationship... cannot be allocated on the basis of a more specific beneficial or causal relationship should be...

  6. 7 CFR 1280.203 - Nominee's agreement to serve.

    Science.gov (United States)

    2010-01-01

    ... contractual relationship with the Board; and (c) Withdraw from participation in deliberations, decision-making....203 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE...

  7. Purification of cyclotron-produced {sup 203}Pb for labeling Herceptin

    Energy Technology Data Exchange (ETDEWEB)

    Garmestani, Kayhan [Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, NCI, Bethesda, MD 20892-1002 (United States); Milenic, Diane E. [Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, NCI, Bethesda, MD 20892-1002 (United States); Brady, Erik D. [Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, NCI, Bethesda, MD 20892-1002 (United States); Plascjak, Paul S. [PET Department, Clinical Center, NIH, Bethesda, MD 20892-1002 (United States); Brechbiel, Martin W. [Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, NCI, Bethesda, MD 20892-1002 (United States)]. E-mail: martinwb@mail.nih.gov

    2005-04-01

    A simple and rapid procedure was developed for the purification of cyclotron-produced {sup 203}Pb via the {sup 203}Tl(d,2n) {sup 203}Pb reaction. A Pb(II) selective ion-exchange resin, with commercial name Pb Resin from Eichrom Technologies, Inc., was used to purify {sup 203}Pb from the cyclotron-irradiated Tl target with excellent recovery of the enriched Tl target material. The purified {sup 203}Pb was used to radiolabel the monoclonal antibody Herceptin. The in vitro and in vivo properties of the {sup 203}Pb radioimmunoconjugate were evaluated.

  8. 75 FR 75693 - Rehabilitation Mortgage Insurance Underwriting Program Section 203(k); Notice of Proposed...

    Science.gov (United States)

    2010-12-06

    ... URBAN DEVELOPMENT Rehabilitation Mortgage Insurance Underwriting Program Section 203(k); Notice of... information: Title of Proposal: Rehabilitation Mortgage Insurance Underwriting Program Section 203(k). OMB... Program Development, Department of Housing and Urban Development, 451 7th Street, SW., Washington,...

  9. 48 CFR 27.203 - Security requirements for patent applications containing classified subject matter.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Security requirements for patent applications containing classified subject matter. 27.203 Section 27.203 Federal Acquisition... subject matter....

  10. 18 CFR 382.203 - Annual charges under the Interstate Commerce Act.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Annual charges under the Interstate Commerce Act. 382.203 Section 382.203 Conservation of Power and Water Resources FEDERAL... § 382.203 Annual charges under the Interstate Commerce Act. (a) The adjusted costs of administration...

  11. 48 CFR 1852.203-70 - Display of Inspector General Hotline Posters.

    Science.gov (United States)

    2010-10-01

    ... General Hotline Posters. 1852.203-70 Section 1852.203-70 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.203-70 Display of Inspector General Hotline Posters. As prescribed in 1803.7001, insert the following clause: Display of Inspector General Hotline Posters (JUN 2001) (a) The...

  12. 48 CFR 1552.203-71 - Display of EPA Office of Inspector General Hotline poster.

    Science.gov (United States)

    2010-10-01

    ... Inspector General Hotline poster. 1552.203-71 Section 1552.203-71 Federal Acquisition Regulations System... Provisions and Clauses 1552.203-71 Display of EPA Office of Inspector General Hotline poster. As prescribed... all contract options. Display of EPA Office of Inspector General Hotline Poster (AUG 2000) (a) For...

  13. 48 CFR 852.203-71 - Display of Department of Veterans Affairs hotline poster.

    Science.gov (United States)

    2010-10-01

    ... Veterans Affairs hotline poster. 852.203-71 Section 852.203-71 Federal Acquisition Regulations System... Provisions and Clauses 852.203-71 Display of Department of Veterans Affairs hotline poster. As prescribed in 803.7001, insert the following clause: Display of Department of Veterans Affairs Hotline Poster...

  14. 7 CFR 160.203 - Fees for inspection and certification of other naval stores material.

    Science.gov (United States)

    2010-01-01

    ... stores material. 160.203 Section 160.203 Agriculture Regulations of the Department of Agriculture... Services Rendered § 160.203 Fees for inspection and certification of other naval stores material. Whenever..., analyze and certify any naval stores material other than spirits of turpentine or rosin, at the request...

  15. 30 CFR 203.82 - What is MMS's authority to collect this information?

    Science.gov (United States)

    2010-07-01

    ... Reports § 203.82 What is MMS's authority to collect this information? The Office of Management and Budget... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What is MMS's authority to collect this information? 203.82 Section 203.82 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE...

  16. 14 CFR 1252.203 - Special benefits for children and the elderly.

    Science.gov (United States)

    2010-01-01

    ... elderly. 1252.203 Section 1252.203 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... Determining Age Discrimination § 1252.203 Special benefits for children and the elderly. If a recipient operating a program or activity provides special benefits to the elderly or to children, such use of...

  17. 22 CFR 40.203 - Alien entitled to A, E, or G nonimmigrant classification.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Alien entitled to A, E, or G nonimmigrant classification. 40.203 Section 40.203 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Failure to Comply with INA § 40.203 Alien entitled to A,...

  18. 32 CFR Appendix A to Part 203 - Technical Assistance for Public Participation Request Form

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Technical Assistance for Public Participation Request Form A Appendix A to Part 203 National Defense Department of Defense (Continued) OFFICE OF THE... DEFENSE ENVIRONMENTAL RESTORATION ACTIVITIES Pt. 203, App. A Appendix A to Part 203—Technical...

  19. 33 CFR 203.44 - Rehabilitation of non-Federal flood control works.

    Science.gov (United States)

    2010-07-01

    ... flood control works. 203.44 Section 203.44 Navigation and Navigable Waters CORPS OF ENGINEERS... DISASTER PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program § 203.44 Rehabilitation of non-Federal flood...

  20. 33 CFR 203.47 - Modifications to non-Federal flood control works.

    Science.gov (United States)

    2010-07-01

    ... flood control works. 203.47 Section 203.47 Navigation and Navigable Waters CORPS OF ENGINEERS... DISASTER PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program § 203.47 Modifications to non-Federal flood...

  1. 24 CFR 203.43e - Eligibility of mortgages covering houses in federally impacted areas.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Eligibility of mortgages covering houses in federally impacted areas. 203.43e Section 203.43e Housing and Urban Development Regulations... Requirements and Underwriting Procedures Eligible Properties § 203.43e Eligibility of mortgages covering...

  2. 48 CFR 1837.203-70 - Providing contractors access to sensitive information.

    Science.gov (United States)

    2010-10-01

    ... require access to sensitive information in the Government's possession, which may be entitled to... access to sensitive information. 1837.203-70 Section 1837.203-70 Federal Acquisition Regulations System... Advisory and Assistance Services 1837.203-70 Providing contractors access to sensitive information....

  3. 48 CFR 627.203 - Patent indemnification of Government by contractor.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Patent indemnification of Government by contractor. 627.203 Section 627.203 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patents 627.203 Patent indemnification...

  4. 48 CFR 252.203-7002 - Requirement to Inform Employees of Whistleblower Rights.

    Science.gov (United States)

    2010-10-01

    ... Employees of Whistleblower Rights. 252.203-7002 Section 252.203-7002 Federal Acquisition Regulations System... Whistleblower Rights. As prescribed in 203.970, use the following clause: Requirement To Inform Employees of Whistleblower Rights (JAN 2009) The Contractor shall inform its employees in writing of employee...

  5. 33 CFR 203.61 - Emergency water supplies due to contaminated water source.

    Science.gov (United States)

    2010-07-01

    ... Water Act (see 40 CFR 141), is exceeded. (ii) The water supply has been identified as a source of... contaminated water source. 203.61 Section 203.61 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT... PROCEDURES Emergency Water Supplies: Contaminated Water Sources and Drought Assistance § 203.61...

  6. 48 CFR 1652.203-70 - Misleading, deceptive, or unfair advertising.

    Science.gov (United States)

    2010-10-01

    ... unfair advertising. 1652.203-70 Section 1652.203-70 Federal Acquisition Regulations System OFFICE OF... CLAUSES Texts of FEHBP Clauses 1652.203-70 Misleading, deceptive, or unfair advertising. As prescribed in... Unfair Advertising (JAN 1991) (a) The Carrier agrees that any advertising material, including...

  7. 24 CFR 203.420 - Nature of Mutual Mortgage Insurance Fund.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Nature of Mutual Mortgage Insurance Fund. 203.420 Section 203.420 Housing and Urban Development Regulations Relating to Housing and Urban... and Distributive Shares § 203.420 Nature of Mutual Mortgage Insurance Fund. The Mutual...

  8. 48 CFR 1631.203-70 - Allocation techniques.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Allocation techniques. 1631... PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 1631.203-70 Allocation techniques. (a... preferred allocation technique is one that shows the consumption of resources in performance of...

  9. 14 CFR 1216.203 - Definition of key terms.

    Science.gov (United States)

    2010-01-01

    ... saturated soil conditions for growth and reproduction. Wetlands generally include swamps, marshes, bogs, and... Floodplain and Wetlands Management § 1216.203 Definition of key terms. (a) Action—any NASA activity including... wetlands. (i) Floodproofing—the modification of individual structures and facilities, their sites,...

  10. 48 CFR 828.203-7 - Exclusion of individual sureties.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Exclusion of individual... Exclusion of individual sureties. The DSPE may make the determinations referenced in FAR 28.203-7: (a) To exclude individuals from acting as surety on bonds; and (b) To accept bonds from individuals named on...

  11. 27 CFR 9.203 - Saddle Rock-Malibu.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Saddle Rock-Malibu. 9.203... Saddle Rock-Malibu. (a) Name. The name of the viticultural area described in this section is “Saddle Rock-Malibu”. For purposes of part 4 of this chapter, “Saddle Rock-Malibu” is a term of...

  12. 5 CFR 2634.203 - Persons excluded by rule.

    Science.gov (United States)

    2010-01-01

    ... FINANCIAL DISCLOSURE, QUALIFIED TRUSTS, AND CERTIFICATES OF DIVESTITURE Persons Required To File Public Financial Disclosure Reports § 2634.203 Persons excluded by rule. (a) In general. Any individual or group of... possible coverage by confidential disclosure rules. (c) Procedure. (1) The exclusion of any individual...

  13. 27 CFR 555.203 - Types of magazines.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Types of magazines. 555... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Storage § 555.203 Types of magazines. For purposes of this part, there are five types of magazines. These types, together with the classes...

  14. 48 CFR 23.203 - Energy-efficient products.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Energy-efficient products... SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water Efficiency and Renewable Energy 23.203...

  15. 24 CFR 203.493 - Declaration of trust.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Declaration of trust. 203.493... Declaration of trust. A sale of a beneficial interest in a group of insured loans, where the interest to be... be made only pursuant to a declaration of trust, which has been approved by the Commissioner prior...

  16. 10 CFR 830.203 - Unreviewed safety question process.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Unreviewed safety question process. 830.203 Section 830... Unreviewed safety question process. (a) The contractor responsible for a hazard category 1, 2, or 3 DOE... a procedure for its USQ process on a schedule that allows DOE approval in a safety evaluation...

  17. 48 CFR 43.203 - Change order accounting procedures.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Change order accounting... CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 43.203 Change order accounting procedures. (a) Contractors' accounting systems are seldom designed to segregate the costs of performing changed...

  18. 24 CFR 203.500 - Mortgage servicing generally.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Servicing Responsibilities General Requirements § 203.500... for denial of insurance benefits, but failure to comply will be cause for imposition of a civil...

  19. 33 CFR 127.203 - Portable gas detectors.

    Science.gov (United States)

    2010-07-01

    ...) WATERFRONT FACILITIES WATERFRONT FACILITIES HANDLING LIQUEFIED NATURAL GAS AND LIQUEFIED HAZARDOUS GAS Waterfront Facilities Handling Liquefied Natural Gas Equipment § 127.203 Portable gas detectors. The marine... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Portable gas detectors....

  20. 20 CFR 633.203 - Review of funding request.

    Science.gov (United States)

    2010-04-01

    ... 633.203 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR MIGRANT AND.... The SGA will identify all review standards including: (a) An understanding of the problems of migrant... capability to administer effectively a diversified employability development program for migrant and...

  1. 9 CFR 113.203 - Feline Panleukopenia Vaccine, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Feline Panleukopenia Vaccine, Killed... REQUIREMENTS Killed Virus Vaccines § 113.203 Feline Panleukopenia Vaccine, Killed Virus. Feline Panleukopenia... shall be individually tested for neutralizing antibody against feline panleukopenia virus to...

  2. 7 CFR 1160.203 - Nominee's agreement to serve.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE FLUID MILK PROMOTION PROGRAM Fluid Milk Promotion Order National Fluid Milk Processor Promotion Board § 1160.203 Nominee's agreement to serve....

  3. 14 CFR 13.203 - Separation of functions.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Separation of functions. 13.203 Section 13... Separation of functions. (a) Civil penalty proceedings, including hearings, shall be prosecuted by an agency attorney. (b) An agency employee engaged in the performance of investigative or prosecutorial functions...

  4. 40 CFR 59.203 - Standards for consumer products.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) NATIONAL VOLATILE ORGANIC COMPOUND EMISSION STANDARDS FOR CONSUMER AND COMMERCIAL PRODUCTS National Volatile Organic Compound Emission Standards for Consumer Products § 59.203 Standards for consumer... not include any VOC that: (1) Has a vapor pressure of less than 0.1 millimeters of mercury at...

  5. 45 CFR 150.203 - Circumstances requiring CMS enforcement.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Circumstances requiring CMS enforcement. 150.203... CARE ACCESS CMS ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS CMS Enforcement Processes for... requiring CMS enforcement. CMS enforces HIPAA requirements to the extent warranted (as determined by CMS)...

  6. 48 CFR 3016.203-470 - Solicitation provision.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Solicitation provision... CONTRACTS Fixed-Price Contracts 3016.203-470 Solicitation provision. The contracting officer shall insert a provision substantially the same as (HSAR) 48 CFR 3052.216-70, Evaluation of Offers Subject to an...

  7. miR-203 downregulates Yes-1 and suppresses oncogenic activity in human oral cancer cells.

    Science.gov (United States)

    Lee, Seul-Ah; Kim, Jae-Sung; Park, Sun-Young; Kim, Heung-Joong; Yu, Sun-Kyoung; Kim, Chun Sung; Chun, Hong Sung; Kim, Jeongsun; Park, Jong-Tae; Go, Daesan; Kim, Do Kyung

    2015-10-01

    The purpose of this study was to elucidate the molecular mechanisms of microRNA-203 (miR-203) as a tumor suppressor in KB human oral cancer cells. MicroRNA microarray results showed that the expression of miR-203 was significantly down-regulated in KB cells compared with normal human oral keratinocytes. The viability of KB cells was decreased by miR-203 in the time- and dose-dependent manners. In addition, over-expressed miR-203 not only increased the nuclear condensation but also significantly increased the apoptotic population of KB cells. These results indicated that the over-expression of miR-203 induced apoptosis of KB cells. Furthermore, the target gene array analyses revealed that the expression of Yes-1, a member of the Src family kinases (SFKs), was significantly down-regulated by miR-203 in KB cells. Moreover, both the mRNA and protein levels of Yes-1 were strongly reduced in KB cells transfected with miR-203. Therefore, these results indicated that Yes-1 is predicted to be a potential target gene of miR-203. Through a luciferase activity assay, miR-203 was confirmed to directly targets the Yes-1 3' untranslated region (UTR) to suppress gene expression. Therefore, our findings indicate that miR-203 induces the apoptosis of KB cells by directly targeting Yes-1, suggesting its application in anti-cancer therapeutics.

  8. BANF1 is downregulated by IRF1-regulated microRNA-203 in cervical cancer.

    Directory of Open Access Journals (Sweden)

    Langyong Mao

    Full Text Available MicroRNAs (miRNAs play important roles in various biological processes and are closely associated with the development of cancer. In fact, aberrant expression of miRNAs has been implicated in numerous cancers. In cervical cancer, miR-203 levels are decreased, although the cause of this aberrant expression remains unclear. In this study, we investigate the molecular mechanisms regulating miR-203 gene transcription. We identify the miR-203 transcription start site by 5' rapid amplification of cDNA ends and subsequently identify the miR-203 promoter region. Promoter analysis revealed that IRF1, a transcription factor, regulates miR-203 transcription by binding to the miR-203 promoter. We also demonstrate that miR-203 targets the 3' untranslated region of BANF1, thus downregulating its expression, whereas miR-203 expression is driven by IRF1. MiR-203 is involved in cell cycle regulation and overexpression of miR-203 suppresses cervical cancer cell proliferation, colony formation, migration and invasion. The inhibitory effect of miR-203 on the cancer cells is partially mediated by downregulating its target, BANF1, since knockdown of BANF1 also suppresses colony formation, migration and invasion.

  9. MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines

    DEFF Research Database (Denmark)

    Viticchiè, Giuditta; Lena, Anna Maria; Latina, Alessia;

    2011-01-01

    transition and invasion of healthy tissues (usually bones). MicroRNA-203 (miR-203) is a tumor suppressor microRNA often silenced in different malignancies. Here, we show that miR-203 is downregulated in clinical primary prostatic tumors compared to normal prostate tissue, and in metastatic prostate cancer...... cell lines compared to normal epithelial prostatic cells. Overexpression of miR-203 in brain or bone metastatic prostate cell lines (DU145 and PC3) is sufficient to induce a mesenchymal to epithelial transition with inhibition of cell proliferation, migration and invasiveness. We have identified CKAP2......, LASP1, BIRC5, WASF1, ASAP1 and RUNX2 as new miR-203 direct target mRNAs involved in these events. Therefore, miR-203 could be a potentially new prognostic marker and therapeutic target in metastatic prostate cancer....

  10. Some health physics aspects of working with 203Hg in university research.

    Science.gov (United States)

    Belanger, M; Westin, A; Barfuss, D W

    2001-02-01

    The radioisotope 203Hg is used in university toxicology research experiments. When our commercial vendor ceased the production of the high specific activity 203Hg we required, an alternative source was sought. Other commercial sources were investigated without success leaving the synthesis of this radioisotope to us. This paper outlines the method we used to synthesize 203Hg and provides a summary of our results to date and a discussion of our experiences.

  11. 7 CFR 760.203 - Eligible losses, adverse weather, and other loss conditions.

    Science.gov (United States)

    2010-01-01

    ... to, flood, freeze, hurricane, hail, tidal surge, volcanic eruption, and wildfire on non-Federal land... 7 Agriculture 7 2010-01-01 2010-01-01 false Eligible losses, adverse weather, and other loss conditions. 760.203 Section 760.203 Agriculture Regulations of the Department of Agriculture (Continued)...

  12. 33 CFR 203.49 - Rehabilitation of Hurricane and Shore Protection Projects.

    Science.gov (United States)

    2010-07-01

    ... Shore Protection Projects. 203.49 Section 203.49 Navigation and Navigable Waters CORPS OF ENGINEERS... authorized hurricane or shore protection structure damaged or destroyed by wind, wave, or water action of an... of damage to a Hurricane/Shore Protection Project. “Prolongation or severity” means a Category 3...

  13. 10 CFR 490.203 - Light Duty Alternative Fueled Vehicle Plan.

    Science.gov (United States)

    2010-01-01

    ... Section 490.203 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.203 Light Duty Alternative Fueled Vehicle Plan. (a) General Provisions... fleets, a State may follow a Light Duty Alternative Fueled Vehicle Plan that has been approved by...

  14. Increased level of basophil CD203c expression predicts severe chronic urticaria.

    Science.gov (United States)

    Ye, Young-Min; Yang, Eun-Mi; Yoo, Hye-Soo; Shin, Yoo-Seob; Kim, Seung-Hyun; Park, Hae-Sim

    2014-01-01

    Increased FcεR1α expression with upregulated CD203c expression on peripheral basophils is seen in patients with chronic urticaria (CU). However, there has been no published report on the association between CD203c expression level and clinical disease activity in CU patients. To investigate whether the increase of basophil activation is associated with the disease activity of CU, we measured basophil CD203c expression using a tricolor flow cytometric method in 82 CU patients and 21 normal controls. The relationship between the percentage of CD203c-expressing basophils and clinical parameters was analyzed. The mean basophil CD203c expression was significantly higher in CU patients than in healthy controls (57.5% vs 11.6%, P basophil CD203c expression in severe CU patients was significantly higher than in non-severe CU (66.5% ± 23.3% vs 54.0% ± 23.3%, P = 0.033). Multiple logistic regression analysis indicated that both ≥ 72% basophil CD203c expression and urticaria activity score (UAS)≥ 13 were significant predictors of severe CU (P = 0.005 and P = 0.032, respectively). These findings suggest that the quantification of basophil activation with CD203c at baseline may be used as a potential predictor of severe CU requiring another treatment option beyond antihistamines.

  15. 30 CFR 203.63 - Does my application have to include all leases in the field?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Does my application have to include all leases in the field? 203.63 Section 203.63 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT RELIEF OR REDUCTION IN ROYALTY RATES OCS Oil, Gas, and Sulfur General Royalty Relief for Pre-Act Deep...

  16. 50 CFR 226.203 - Critical habitat for northern right whales.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Critical habitat for northern right whales. 226.203 Section 226.203 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND... Critical habitat for northern right whales. (a) Great South Channel. The area bounded by 41°40′ N/69°45′...

  17. 30 CFR 203.75 - What risk do I run if I request a redetermination?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What risk do I run if I request a redetermination? 203.75 Section 203.75 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... run if I request a redetermination? If you request a redetermination after we have granted you...

  18. 40 CFR 266.203 - Standards applicable to the transportation of solid waste military munitions.

    Science.gov (United States)

    2010-07-01

    ... transportation of solid waste military munitions. 266.203 Section 266.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS... applicable to the transportation of solid waste military munitions. (a) Criteria for hazardous...

  19. 24 CFR 203.52 - Acceptance of individual residential water purification equipment.

    Science.gov (United States)

    2010-04-01

    ... residential water purification equipment. 203.52 Section 203.52 Housing and Urban Development Regulations... water purification equipment. If a property otherwise eligible for insurance under this part does not have access to a continuing supply of safe and potable water without the use of a water...

  20. 31 CFR 203.11 - Same-day reporting and payment mechanisms.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Same-day reporting and payment mechanisms. 203.11 Section 203.11 Money and Finance: Treasury Regulations Relating to Money and Finance... payment mechanisms. (a) General. A financial institution or its authorized correspondent may initiate...

  1. 7 CFR 59.203 - Mandatory daily reporting for sows and boars.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Mandatory daily reporting for sows and boars. 59.203... (CONTINUED) LIVESTOCK MANDATORY REPORTING Swine Reporting § 59.203 Mandatory daily reporting for sows and boars. (a) Prior day report. The corporate officers or officially designated representatives of...

  2. 21 CFR 20.3 - Certification and authentication of Food and Drug Administration records.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Certification and authentication of Food and Drug Administration records. 20.3 Section 20.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... authentication of Food and Drug Administration records. (a) Upon request, the Food and Drug Administration...

  3. 27 CFR 26.203 - Containers of 1 gallon (3.785 liters) or less.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Containers of 1 gallon (3.785 liters) or less. 26.203 Section 26.203 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO... gallon (3.785 liters) or less. Containers of distilled spirits brought into the United States from...

  4. 33 CFR 203.48 - Inspection guidelines for non-Federal flood control works.

    Science.gov (United States)

    2010-07-01

    ...-Federal flood control works. 203.48 Section 203.48 Navigation and Navigable Waters CORPS OF ENGINEERS... DISASTER PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm..., construction, and maintenance of non-Federal flood control works. The guidelines are not intended to...

  5. 33 CFR 203.50 - Nonstructural alternatives to rehabilitation of flood control works.

    Science.gov (United States)

    2010-07-01

    ... rehabilitation of flood control works. 203.50 Section 203.50 Navigation and Navigable Waters CORPS OF ENGINEERS... DISASTER PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm... of flood control works. (a) Authority. Under Public Law 84-99, the Chief of Engineers is...

  6. 38 CFR 1.203 - Information to be reported to VA Police.

    Science.gov (United States)

    2010-07-01

    ... reported to VA Police. 1.203 Section 1.203 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... be reported to VA Police. Information about actual or possible violations of criminal laws related to... occurs on VA premises, will be reported by VA management officials to the VA police component...

  7. 5 CFR 295.203 - Filing requirements for demands or requests for documents or testimony.

    Science.gov (United States)

    2010-01-01

    ... requests for documents or testimony. 295.203 Section 295.203 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS TESTIMONY BY OPM EMPLOYEES RELATING TO OFFICIAL INFORMATION AND PRODUCTION OF OFFICIAL RECORDS IN LEGAL PROCEEDINGS Requests for Testimony and Production of Documents §...

  8. 27 CFR 19.203 - Alternation of distilled spirits plant and bonded wine cellar premises.

    Science.gov (United States)

    2010-04-01

    ... spirits plant and bonded wine cellar premises. 19.203 Section 19.203 Alcohol, Tobacco Products and... spirits plant and bonded wine cellar premises. (a) General. A proprietor of a distilled spirits plant operating a contiguous bonded wine cellar desiring to alternate the use of each premises by extension...

  9. 5 CFR 2638.203 - Duties of the designated agency ethics official.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Duties of the designated agency ethics official. 2638.203 Section 2638.203 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Designated Agency...

  10. 48 CFR 2152.203-70 - Misleading, deceptive, or unfair advertising.

    Science.gov (United States)

    2010-10-01

    ... unfair advertising. 2152.203-70 Section 2152.203-70 Federal Acquisition Regulations System OFFICE OF..., deceptive, or unfair advertising. As prescribed in 2103.571, insert the following clause: Misleading, Deceptive, or Unfair Advertising (OCT 2005) The Contractor agrees that any advertising material...

  11. Effect of vitamin D on the intestinal absorption of 203Pb and 47Ca in chicks

    Energy Technology Data Exchange (ETDEWEB)

    Mykkaenen, H.M.; Wasserman, R.H.

    1982-03-01

    The transfer of 203Pb and/or 47Ca across the intestinal epithelium of the chick was investigated, with emphasis given to the functional role of cholecalciferol (vitamin D-3). 203Pb, after introduction in the intestinal lumen, is rapidly accumulated by the intestinal tissue, and only a fraction of 203Pb is translocated parenterally (absorbed). Cholecalciferol did not significantly affect the accumulation of 203Pb by intestinal tissue but did accelerate 203Pb movement across the basal-lateral membrane. In contrast, cholecalciferol both decreased 47Ca tissue levels and increased 47Ca absorption. In rachitic chicks, the rate of absorption of 203Pb was greater in the distal than in the proximal segments of the intestine; after cholecalciferol repletion, the degree of absorption in al segments was similar, indicting the order of cholecalciferol effectiveness as duodenum greater than or equal to jejunum greater than ileum. An acute dose of 1,25(OH)2D3 to rachitic chicks also enhanced both 203Pb and 47Ca absorption, but the time course and pattern of absorption of these metal cations differed. The time at which the absorption of 203Pb peaked and returned to base-line occurred sooner than for 47Ca. Also the back-flux (blood leads to intestinal lumen) of 47Ca was enhanced by cholecalciferol, whereas no effect on the back-flux of 203Pb was noted. These studies show that cholecalciferol and 1,25(OH)2D3 affects both the 203Pb and 47Ca absorptive processes, but the nature of these responses are not identical, suggesting differences in the transport path or the macromolecular interactions of these metal ions during the course of absorption, or both.

  12. 30 CFR 203.68 - What pre-application costs will MMS consider in determining economic viability?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What pre-application costs will MMS consider in determining economic viability? 203.68 Section 203.68 Mineral Resources MINERALS MANAGEMENT SERVICE... § 203.68 What pre-application costs will MMS consider in determining economic viability? (a) We will...

  13. 14 CFR 203.4 - Montreal Agreement as part of airline-passenger contract and conditions of carriage.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Montreal Agreement as part of airline-passenger contract and conditions of carriage. 203.4 Section 203.4 Aeronautics and Space OFFICE OF THE... CONVENTION LIABILITY LIMITS AND DEFENSES § 203.4 Montreal Agreement as part of airline-passenger contract...

  14. 24 CFR 203.666 - Processing defaulted mortgages on property in Allegany Reservation of Seneca Nation of Indians.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Processing defaulted mortgages on property in Allegany Reservation of Seneca Nation of Indians. 203.666 Section 203.666 Housing and Urban... Indians § 203.666 Processing defaulted mortgages on property in Allegany Reservation of Seneca Nation...

  15. 24 CFR 203.439a - Mortgages on property in Allegany Reservation of Seneca Nation of Indians authorized by section...

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgages on property in Allegany Reservation of Seneca Nation of Indians authorized by section 203(q) of the National Housing Act. 203.439a... Reservation of Seneca Indians § 203.439a Mortgages on property in Allegany Reservation of Seneca Nation...

  16. Increased Level of Basophil CD203c Expression Predicts Severe Chronic Urticaria

    OpenAIRE

    Ye, Young-Min; Yang, Eun-Mi; Yoo, Hye-Soo; Shin, Yoo-Seob; Kim, Seung-Hyun; Park, Hae-Sim

    2013-01-01

    Increased FcεR1α expression with upregulated CD203c expression on peripheral basophils is seen in patients with chronic urticaria (CU). However, there has been no published report on the association between CD203c expression level and clinical disease activity in CU patients. To investigate whether the increase of basophil activation is associated with the disease activity of CU, we measured basophil CD203c expression using a tricolor flow cytometric method in 82 CU patients and 21 normal con...

  17. Porcine ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1/CD203a)

    DEFF Research Database (Denmark)

    Petersen, Cathrine Bie; Hillig, Ann-Britt Nygaard; Viuff, Birgitte;

    2007-01-01

    /phosphodiesterase 1 (NPP1/CD203a). The porcine NPP1/CD203a encoding gene was mapped to chromosome 1 using a radiation hybrid panel, and transcription was investigated by RT-PCR analysis of several tissues. The cDNA was cloned and introduced into COS7 cells resulting in expression of functionally active enzyme...... and verification of the specificity of an SWC9 reacting monoclonal antibody. The antibody was used for immunohistochemical examination of various porcine tissues. Most prominent expression of NPP1/CD203a was found in lung macrophages and liver sinusoids....

  18. COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Qi, Huan; Zuo, Dai-Ying; Bai, Zhao-Shi; Xu, Jing-Wen; Li, Zeng-Qiang [Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang (China); Shen, Qi-Rong; Wang, Zhi-Wei [Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang (China); Zhang, Wei-Ge, E-mail: zhangweige2000@sina.com [Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang (China); Wu, Ying-Liang, E-mail: yingliang_1016@163.com [Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang (China)

    2014-12-12

    Highlights: • COH-203 exhibits anti-hepatoma effects in vitro and in vivo with low toxicity. • COH-203 inhibits tubulin polymerization. • COH-203 induces mitotic arrest followed by mitotic slippage in BEL-7402 cells. • COH-203 induces p53-dependent senescence in BEL-7402 cells. - Abstract: 5-(3-Hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-3H-1, 2-dithiol-3-one (COH-203) is a novel synthesized analogue of combretastatin A-4 that can be classified as a microtubule inhibitor. In this study, we evaluated the anti-hepatoma effect of COH-203 in vitro and in vivo and explored the underlying molecular mechanisms. COH-203 was shown to be more effective in inhibiting the proliferation of liver cancer cells compared with normal liver cells. COH-203 also displayed potent anti-tumor activity in a hepatocellular carcinoma xenograft model without significant toxicity. Mechanistic studies demonstrated that treatment with COH-203 induced mitotic arrest by inhibiting tubulin polymerization in BEL-7402 liver cancer cells. Long-term COH-203 treatment in BEL-7402 cells led to mitotic slippage followed by senescence via the p14{sup Arf}–p53–p21 and p16{sup INK4α}–Rb pathways. Furthermore, suppression of p53 via pifithrin-α (p53 inhibitor) and p53-siRNA attenuated COH-203-induced senescence in BEL-7402 cells, suggesting that COH-203 induced senescence p53-dependently. In conclusion, we report for the first time that COH-203, one compound in the combretastatin family, promotes anti-proliferative activity through the induction of p-53 dependent senescence. Our findings will provide a molecular rationale for the development of COH-203 as a promising anti-tumor agent.

  19. Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis.

    Science.gov (United States)

    Pruszyński, Marek; Bilewicz, Aleksander; Zalutsky, Michael R

    2008-04-01

    The goal of this study was to evaluate a new approach that can be applied for labeling biomolecules with (211)At. Many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking different (211)At labeling strategies. The approach evaluated in this study was to attach astatide anions to soft metal cations, which are also complexed by a bifunctional ligand. Ultimately, this complex could in principle be subsequently conjugated to a biomolecule with the proper selection of ligand functionality. We report here the attachment of (211)At(-) and *I(-) (*I = (131)I or (125)I) anions to the soft metal cations Rh(III) and Ir(III), which are complexed by the 1,5,9,13-tetrathiacyclohexadecane-3,11-diol (16aneS4-diol) ligand. Radioactive *I(-) anions were used for preliminary studies directed at the optimization of reaction conditions and to provide a baseline for comparison of results with (211)At. Four complexes Rh[16aneS4-diol]*I/(211)At and Ir[16aneS4-diol]*I/(211)At were synthesized in high yield in a one-step procedure, and the products were characterized mainly by paper electrophoresis and reversed-phase HPLC. The influences of time and temperature of heating and concentrations of metal cations and sulfur ligand 16aneS4-diol, as well as pH on the reaction yields were determined. Yields of about 80% were obtained when the quantities of Rh(III) or Ir(III) cations and 16aneS4-diol ligand in the solutions were 62.5 nmol and 250 nmol, respectively, and the pH ranged 3.0-4.0. Syntheses required heating for 1-1.5 h at 75-80 degrees C. The influence of microwave heating on the time and completeness of the complexation reaction was evaluated and compared with the conventional method of heating in an oil bath. Microwave synthesis accelerates reactions significantly. With microwave heating, yields of about 75% for Rh[16aneS4-diol](131)I and Ir[16aneS4-diol](131)I complexes were obtained after only 20 min exposure of the reaction mixtures to

  20. 78 FR 20168 - Twenty Fourth Meeting: RTCA Special Committee 203, Unmanned Aircraft Systems

    Science.gov (United States)

    2013-04-03

    ... Federal Aviation Administration Twenty Fourth Meeting: RTCA Special Committee 203, Unmanned Aircraft Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION.../Approval of Twenty Third Plenary Meeting Summary Leadership Update Workgroup Progress...

  1. Molecular cloning of a cDNA related to vernalization(verc203) in winter wheat

    Institute of Scientific and Technical Information of China (English)

    种康; 谭克辉; 黄华梁; 梁厚果

    1995-01-01

    A cDNA clone related to the vernalization in winter wheat(verc203)was harvested from the en-riched cold-induced cDNA library of 10~4 pfu with differential screening.The insert of verc203 in λ gt10 vector wassubcloned into the sites between BamH Ⅰ and Hind Ⅲ in pUC19 plasmid after being amplified with PCR.the analysis of the Northern blotting with a probe of verc203 indicated that the verc203 has a negative signalfor the control and the devernalized mRNA and a positive signal for the vernalized winter wheat and non-vernalized spring wheat at about 2.6 kb.

  2. econ203 full course latest 2015 november [ all discussions all homework and all quizzes

    OpenAIRE

    Laynebaril1

    2017-01-01

      econ203 full course latest 2015 november [ all discussions all homework and all quizzes ] Click Link Below To Buy: http://hwcampus.com/shop/econ203-full-course/   homework 1 Your quiz has been submitted successfully. Chapter 1_ a command economy Question 1 1 / 1 point In countries like _____________ the command economy predominates. a) Germany and France b) Cuba and North Korea c) China and Vietnam d) South Africa and Kenya Chapter 1_marke...

  3. Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats

    OpenAIRE

    Berend, Suzana; Lucić Vrdoljak, Ana; Musilek, Kamil; Kuča, Kamil; Radić, Božica

    2012-01-01

    The highly toxic nature of tabun has been known for many years, but there are still serious limitations to antidotal therapy. In this study, we used rats as an experimental model to evaluate the efficiency of bispyridinium para-oxime K203 as therapy against tabun poisoning as well as to examine if induction of oxidative stress is linked to organophosphate toxicity. K203 showed high potency in counteracting tabun poisoning. Either alone or in combination with atropine, this oxime s...

  4. A norming study and library of 203 dance movements.

    Science.gov (United States)

    Christensen, Julia F; Nadal, Marcos; Cela-Conde, Camilo José

    2014-01-01

    Dance stimuli have been used in experimental studies of (i) how movement is processed in the brain; (ii) how affect is perceived from bodily movement; and (iii) how dance can be a source of aesthetic experience. However, stimulus materials across--and even within--these three domains of research have varied considerably. Thus, integrative conclusions remain elusive. Moreover, concerns have been raised that the movements selected for such stimuli are qualitatively too different from the actual art form dance, potentially introducing noise in the data. We propose a library of dance stimuli which responds to the stimuli requirements and design criteria of these three areas of research, while at the same time respecting a dance art-historical perspective, offering greater ecological validity as compared with previous dance stimulus sets. The stimuli are 5-6 s long video clips, selected from genuine ballet performances. Following a number of coding experiments, the resulting stimulus library comprises 203 ballet dance stimuli coded in (i) 25 qualitative and quantitative movement variables; (ii) affective valence and arousal; and (iii) the aesthetic qualities beauty, liking, and interest. An Excel spreadsheet with these data points accompanies this manuscript, and the stimuli can be obtained from the authors upon request.

  5. miR-203 inhibits melanoma invasive and proliferative abilities by targeting the polycomb group gene BMI1

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Xiao [Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China); Sun, Yong [Department of Burn and Plastic Surgery, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300 (China); Han, Siqi [Department of Medical Oncology, Jinling Hospital, Nanjing 210002 (China); Zhu, Wei [Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China); Zhang, Haiping, E-mail: zhanghaiping_2000@163.com [Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China); Lian, Shi, E-mail: lianshi_2020@163.com [Department of Dermatology and Venereal Disease, Capital Medical University, Beijing 100069 (China)

    2015-01-02

    Highlights: • First reported deregulation of miR-203 and up-regulation of BMI1 in metastatic melanoma. • miR-203 decreased BMI1 expression by directly binding to 3′UTR. • Further found miR-203 overexpression suppressed cell invasion and stemness. • Re-expression of BMI1 rescued miR-203-mediated suppression. • miR-203-BMI1 axis may be potential therapeutic targets of melanoma metastasis. - Abstract: Metastasis is the major problem in malignant melanoma, posing a therapeutic challenge to clinicians. The investigation of the underlying mechanism driving this progress remains a large unmet need. In this study, we revealed a miR-203-BMI1 axis that regulated melanoma metastasis. We found significantly deregulation of miR-203 and up-regulation of BMI1 in melanoma, particularly in metastatic melanoma. An inverse correlation between the levels of miR-203 and BMI1 was further observed in melanoma tissues and cell lines. We also identified BMI1 as a downstream target gene of miR-203, which bound to the 3′UTR of BMI1. Overexpression of miR-203 was associated with decreased BMI1 expression and impaired cell invasion and tumor sphere formation activities. Re-expression of BMI1 markedly rescued miR-203-mediated suppression of these events. Taken together, our results demonstrated that miR-203 regulated melanoma invasive and proliferative abilities in part by targeting BMI1, providing new insights into potential mechanisms of melanoma metastasis.

  6. 49 CFR 173.203 - Non-bulk packagings for liquid hazardous materials in Packing Group III.

    Science.gov (United States)

    2010-10-01

    ... in Packing Group III. 173.203 Section 173.203 Transportation Other Regulations Relating to... materials in Packing Group III. (a) When § 172.101 of this subchapter specifies that a liquid hazardous... of part 173, to the requirements of part 178 of this subchapter at the Packing Group I, II or...

  7. 45 CFR 46.203 - Duties of IRBs in connection with research involving pregnant women, fetuses, and neonates.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Duties of IRBs in connection with research involving pregnant women, fetuses, and neonates. 46.203 Section 46.203 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Additional Protections for Pregnant Women, Human Fetuses and Neonates...

  8. 12 CFR Appendix B to Part 203 - Form and Instructions for Data Collection on Ethnicity, Race, and Sex

    Science.gov (United States)

    2010-01-01

    ... Ethnicity, Race, and Sex B Appendix B to Part 203 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF... to Part 203—Form and Instructions for Data Collection on Ethnicity, Race, and Sex I. Instructions on Collection of Data on Ethnicity, Race, and Sex You may list questions regarding the ethnicity, race, and...

  9. 16 CFR Appendix D to Part 436 - Sample Item 20(3) Table-Status of Franchise Outlets

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Sample Item 20(3) Table-Status of Franchise Outlets D Appendix D to Part 436 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES... Item 20(3) Table—Status of Franchise Outlets Status of Franchise Outlets For years 2004 to 2006...

  10. 24 CFR 203.43j - Eligibility of mortgages on Allegany Reservation of Seneca Nation of Indians.

    Science.gov (United States)

    2010-04-01

    ... Allegany Reservation of Seneca Nation of Indians. 203.43j Section 203.43j Housing and Urban Development... Reservation of Seneca Nation of Indians. A mortgage on a leasehold estate covering a one- to four-family residence located on the Allegany Reservation of the Seneca Nation of Indians in the State of New York...

  11. 9 CFR 203.4 - Statement with respect to the disposition of records by packers, live poultry dealers, stockyard...

    Science.gov (United States)

    2010-01-01

    ... disposition of records by packers, live poultry dealers, stockyard owners, market agencies and dealers. 203.4... STOCKYARDS ACT § 203.4 Statement with respect to the disposition of records by packers, live poultry dealers... Stockyards Act (7 U.S.C. 221) provides, in part, that every packer, live poultry dealer, stockyard...

  12. miR-203 inhibits cell proliferation and promotes cisplatin induced cell death in tongue squamous cancer.

    Science.gov (United States)

    Lin, Jiong; Lin, Yao; Fan, Li; Kuang, Wei; Zheng, Liwei; Wu, Jiahua; Shang, Peng; Wang, Qiaofeng; Tan, Jiali

    2016-04-29

    Oral squamous cell carcinoma (OSCC) is one of the most common types of the head and neck cancer. Chemo resistance of OSCC has been identified as a substantial therapeutic hurdle. In this study, we analyzed the role of miR-203 in the OSCC and its effects on cisplatin-induced cell death in an OSCC cell line, Tca8113. There was a significant decrease of miR-203 expression in OSCC samples, compared with the adjacent normal, non-cancerous tissue. After 3 days cisplatin treatment, the survived Tca8113 cells had a lower expression of miR-203 than that in the untreated control group. In contrast, PIK3CA showed an inverse expression in cancer and cisplatin survived Tca8113 cells. Transfection of Tca8113 cells with miR-203 mimics greatly reduced PIK3CA expression and Akt activation. Furthermore, miR-203 repressed PIK3CA expression through targeting the 3'UTR. Restoration of miR-203 not only suppressed cell proliferation, but also sensitized cells to cisplatin induced cell apoptosis. This effect was absent in cells that were simultaneously treated with PIK3CA RNAi. In summary, these findings suggest miR-203 plays an important role in cisplatin resistance in OSCC, and furthermore delivery of miR-203 analogs may serve as an adjuvant therapy for OSCC.

  13. 24 CFR 203.16 - Certificate and contract regarding use of dwelling for transient or hotel purposes.

    Science.gov (United States)

    2010-04-01

    ... use of dwelling for transient or hotel purposes. 203.16 Section 203.16 Housing and Urban Development... use of dwelling for transient or hotel purposes. Every application filed with respect to insurance of... housing or any part thereof covered by the mortgage for transient or hotel purposes, together with...

  14. 12 CFR 347.203 - Deposit insurance required for all branches of foreign banks engaged in domestic retail deposit...

    Science.gov (United States)

    2010-01-01

    ... foreign banks engaged in domestic retail deposit activity in the same State. 347.203 Section 347.203 Banks... engaged in domestic retail deposit activity in the same State. The FDIC will not insure deposits in any... foreign bank in the same state that engages in domestic retail deposit activity will be an insured branch....

  15. 24 CFR 203.390 - Waiver of title-mortgages or property formerly held by the Secretary.

    Science.gov (United States)

    2010-04-01

    ... property formerly held by the Secretary. 203.390 Section 203.390 Housing and Urban Development Regulations... formerly held by the Secretary. (a) Mortgages sold by the Secretary. (1) If the Secretary sells a mortgage... Secretary. (1) If a property held by the Secretary is sold by the Secretary who also insures a...

  16. 42 CFR 137.203 - May a Self-Governance Tribe participate in a voluntary national uniform data collection effort...

    Science.gov (United States)

    2010-10-01

    ... voluntary national uniform data collection effort with the IHS? 137.203 Section 137.203 Public Health PUBLIC...-Governance Tribe participate in a voluntary national uniform data collection effort with the IHS? Yes, in... participate, at its option, in national IHS data reporting activities such as Government Performance...

  17. 23 CFR 636.203 - What are the elements of two-phase selection procedures for competitive proposals?

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false What are the elements of two-phase selection procedures for competitive proposals? 636.203 Section 636.203 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING Selection...

  18. Gavatero-203, nueva variedad de sorgo forrajero para el estado de Sinaloa Gavatero-203, new sorghum forage cultivar for the State of Sinaloa

    Directory of Open Access Journals (Sweden)

    Luis Alberto Hernández Espinal

    2010-12-01

    Full Text Available La nueva variedad de sorgo Gavatero-203, fue desarrollado en el Campo Experimental Valle de Culiacán del INIFAP y registrado con el número 2205-SOG-529-090209/C en el catálogo de variedades factibles de certificación de México. Esta variedad se adapta a las áreas productoras de sorgo para el estado de Sinaloa. Gavatero-203 es una variedad de grano rojo y se recomienda para condiciones de riego y temporal. El rendimiento promedio de la variedad es de 2 849 kg ha-1 de grano y 35 367 kg ha-1 de forraje verde, supera en promedio 18.5% y 15.4% respectivamente al rendimiento de híbridos comerciales de compañías privadas, que se cultivan en la región bajo las mismas condiciones. Gavatero-203 tiene mejor calidad bromatológica que los híbridos comerciales en el forraje, con un 7.3% de proteína y 66.4% de digestibilidad, supera en promedio 1% y 6% respectivamente, a los híbridos comerciales. Es tolerante a enfermedades que se presentan en la región, como son: ergot (Claviceps african, antracnosis (Colletotrichum graminícola, tizón de la panoja (Fusarium moniliforme y pudrición carbonosa del tallo (Macrophomina phaseolina. El forraje de sorgo Gavatero-203, se recomienda como un material de doble propósito en prácticas de conservación de forraje como henificado y ensilaje.The new sorghum variety Gavatero-203 was developed at Culiacán Valley Experiment Station of the National Research Forestry, Agriculture and Livestock Institute (INIFAP and was registered with the number 2205-SOG-529-090209/C in the Catalogue of Feasible Varieties of Certification in Mexico. This variety is adapted to sorghum-producing areas in State of Sinaloa, Mexico.The variety Gavatero-203 has red grain and is recommended either for irrigation and rainfall areas. The average yield of the variety is 2 849 kg ha-1 of grain and 35 367 kg ha-1 of green forage, which is 18.5% and 15.4% higher than the grain and fresh forage yield of commercial hybrids from private

  19. 胃癌患者外周血microRNA-203的检测及意义

    Institute of Scientific and Technical Information of China (English)

    邵文

    2012-01-01

    目的探讨胃癌患者外周血microRNA-203的表达及临床意义。方法采用RT—PCR方法检测20例胃癌患者、10例健康志愿者外周血中microRNA-203的表达。结果胃癌组和正常对照组外周血中microRNA-203的表达有显著差异(P〈0.01)。胃癌组外周血中microRNA-203的表达水平较正常对照组明显下调。结论外周血中microRNA-203的检测可作为胃癌早期诊断的标志物。

  20. 胃癌患者外周血microRNA-203的检测及意义

    Institute of Scientific and Technical Information of China (English)

    邵文

    2012-01-01

    目的 探讨胃癌患者外周血microRNA-203的表达及临床意义.方法 采用RT-PCR方法检测20例胃癌患者、10例健康志愿者外周血中microRNA-203的表达.结果 胃癌组和正常对照组外周血中microRNA-203的表达有显著差异(P<0.01).胃癌组外周血中microRNA-203的表达水平较正常对照组明显下调.结论 外周血中microRNA-203的检测可作为胃癌早期诊断的标志物.

  1. Effect of vitamin D on the intestinal absorption of /sup 203/Pb and /sup 47/Ca in chicks

    Energy Technology Data Exchange (ETDEWEB)

    Mykkaenen, H.M.; Wasserman, R.H.

    1982-03-01

    The transfer of /sup 203/Pb and/or /sup 47/Ca across the intestinal epithelium of the chick was investigated, with emphasis given to the functional role of cholecalciferol (vitamin D-3). /sup 203/Pb, after introduction in the intestinal lumen, is rapidly accumulated by the intestinal tissue, and only a fraction of /sup 203/ Pb is translocated parenterally (absorbed). Cholecalciferol did not significantly affect the accumulation of /sup 203/Pb by intestinal tissue but did accelerate /sup 203/Pb movement across the basal-lateral membrane. In contrast, cholecalciferol both decreased /sup 47/Ca tissue levels and increased /sup 47/Ca absorption. In rachitic chicks, the rate of absorption of /sup 203/Pb was greater in the distal than in the proximal segments of the intestine; after cholecalciferol repletion, the degree of absorption in all segments was similar, indicating the order of cholecalciferol effectiveness as duodenum greater than or equal to jejunum > ileum. An acute dose of 1,25(OH)/sub 2/D/sub 3/ to rachitic chicks also enhanced both /sup 203/Pb and /sup 47/Ca absorption, but the time course and pattern of absorption of these metal cations differed. The time at which the absorption of /sup 203/Pb peaked and returned to base-line occurred sooner than for /sup 47/Ca. Also the back-flux (blood ..-->.. intestinal lumen) of /sup 47/Ca was enhanced by cholecalciferol, whereas no effect on the back-flux of /sup 203/Pb was noted. These studies show that cholecalciferol and 1,25(OH)/sub 2/D/sub 3/ affects both the /sup 203/Pb and /sup 47/Ca absorptive processes, but the nature of these responses are not identical, suggesting differences in the transport path or the macromolecular interactions of these metal ions during the course of absorption, or both.

  2. 20 CFR 25.203 - How is the Special Schedule applied to non-resident aliens in the Territory of Guam?

    Science.gov (United States)

    2010-04-01

    ...-resident aliens in the Territory of Guam? 25.203 Section 25.203 Employees' Benefits OFFICE OF WORKERS... Compensation § 25.203 How is the Special Schedule applied to non-resident aliens in the Territory of Guam? (a... on or after July 1, 1971 in the Territory of Guam to non-resident alien employees recruited...

  3. 24 CFR 203.33 - Relationship of income to mortgage payments.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Relationship of income to mortgage... Mortgagors § 203.33 Relationship of income to mortgage payments. (a) Adequacy of mortgagor's gross income. A mortgagor must establish, to the satisfaction of the Secretary, that his or her gross income is and will...

  4. 24 CFR 203.319 - Pro rata payment of premiums and charges.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Pro rata payment of premiums and... § 203.319 Pro rata payment of premiums and charges. No contract of insurance shall be terminated until the mortgagee has paid to the Commissioner the pro rata portion of the current annual MIP or...

  5. 24 CFR 203.268 - Pro rata payment of periodic MIP.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Pro rata payment of periodic MIP...-Periodic Payment § 203.268 Pro rata payment of periodic MIP. (a) If the insurance contract is terminated... rata MIP shall not be due or payable where the mortgagee notifies the Commissioner that foreclosure...

  6. 30 CFR 203.85 - What is in an economic viability and relief justification report?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What is in an economic viability and relief... Required Reports § 203.85 What is in an economic viability and relief justification report? This report... economic viability and relief justification report must contain the following items for an oil and...

  7. 48 CFR 52.203-14 - Display of Hotline Poster(s).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Display of Hotline Poster... Clauses 52.203-14 Display of Hotline Poster(s). As prescribed in 3.1004(b), insert the following clause: Display of Hotline Poster(s) (DEC 2007) (a) Definition. United States, as used in this clause, means...

  8. 7 CFR 1744.203 - Establishing amount of rural development investment.

    Science.gov (United States)

    2010-01-01

    ... investment shall be the total amount of funds committed to the rural development project as of the date of... 7 Agriculture 11 2010-01-01 2010-01-01 false Establishing amount of rural development investment... INSURED TELEPHONE LOANS Borrower Investments § 1744.203 Establishing amount of rural...

  9. 41 CFR 50-203.1 - Reports of breach or violation.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Reports of breach or... of the Walsh-Healey Public Contracts Act § 50-203.1 Reports of breach or violation. (a) Any employer, employee, labor or trade organization or other interested person or organization may report a breach...

  10. 43 CFR 20.203 - Exclusion from confidential financial disclosure requirement for certain special Government...

    Science.gov (United States)

    2010-10-01

    ... § 20.203 Exclusion from confidential financial disclosure requirement for certain special Government... reporting requirements of the OGE Form 450. Any confidential financial disclosure requirement must be... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Exclusion from confidential...

  11. 33 CFR 203.85 - Rehabilitation of Federal flood control projects.

    Science.gov (United States)

    2010-07-01

    ... PROCEDURES Local Interests/Cooperation Agreements § 203.85 Rehabilitation of Federal flood control projects. Some sponsors of Federal flood control projects are not required to furnish written assurances of local... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Rehabilitation of Federal...

  12. 33 CFR 203.42 - Inspection of non-Federal flood control works.

    Science.gov (United States)

    2010-07-01

    ... PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program § 203.42 Inspection of non-Federal flood control works. (a) Required inspections. The Corps will conduct inspections of non-Federal flood control works. These inspections are...

  13. 33 CFR 203.45 - Rehabilitation of Federal flood control works.

    Science.gov (United States)

    2010-07-01

    ... PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program § 203.45 Rehabilitation of Federal flood control works. Rehabilitation of Federal flood control projects will be identical to rehabilitation of non-Federal projects (§...

  14. 33 CFR 203.43 - Inspection of Federal flood control works.

    Science.gov (United States)

    2010-07-01

    ... PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program § 203.43 Inspection of Federal flood control works. (a) Required inspections. A completed Federal flood control project, or completed functional portions thereof, is...

  15. External monitoring of /sup 203/Hg-labelled Dirofilaria immitis microfilariae in mice and dogs

    Energy Technology Data Exchange (ETDEWEB)

    Lengemann, F.W.; Grieve, R.B.; Chmielewicz, M.; Kallfelz, F.A.; Georgi, J.R.

    1986-04-01

    Microfilariae of Dirofilaria immitis were labelled with /sup 203/Hg/sup 2 +/ in vitro and injected into irradiated mice and Beagle dogs. With irradiated mice it was possible to demonstrate microfilariae present in the blood and to detect /sup 203/Hg by external counting as long as 28 days after dosing. The /sup 203/Hg/sup 2 +/ label had a half-time of 4-5 days; the amount of stable mercury in the labelling medium strongly influenced the survival of microfilariae in vivo. In dogs, external counting showed the lungs to be a major location of microfilariae soon after reinjection into the host. Evidence was obtained that labelled microfilariae can circulate; however, the detection of dispersed microfilariae is difficult because of the relative insensitivity of the detecting system. For radiomercury the accumulation of the inorganic form in the liver and kidneys limits the long-term usefulness of /sup 203/Hg/sup 2 +/ as a label if the organism being studied also accumulates in these organs.

  16. 21 CFR 203.39 - Donation of drug samples to charitable institutions.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Donation of drug samples to charitable... SERVICES (CONTINUED) DRUGS: GENERAL PRESCRIPTION DRUG MARKETING Samples § 203.39 Donation of drug samples... donation record accurately describes the drug sample delivered and that no drug sample is adulterated...

  17. 24 CFR 3280.203 - Flame spread limitations and fire protection requirements.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Flame spread limitations and fire... Fire Safety § 3280.203 Flame spread limitations and fire protection requirements. (a) Establishment of flame spread rating. The surface flame spread rating of interior-finish material must not exceed...

  18. 24 CFR 203.610 - Relief for mortgagor in military service.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Servicing Responsibilities Mortgagee Action and Forbearance § 203... person in the military service as that term is defined in the Soldiers and Sailors Civil Relief Act...

  19. 21 CFR 203.50 - Requirements for wholesale distribution of prescription drugs.

    Science.gov (United States)

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) DRUGS: GENERAL PRESCRIPTION DRUG MARKETING Wholesale Distribution § 203.50 Requirements for wholesale distribution of prescription drugs. (a) Identifying statement for sales by... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Requirements for wholesale distribution...

  20. 7 CFR 205.203 - Soil fertility and crop nutrient management practice standard.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Soil fertility and crop nutrient management practice... Requirements § 205.203 Soil fertility and crop nutrient management practice standard. (a) The producer must..., and biological condition of soil and minimize soil erosion. (b) The producer must manage...

  1. 13 CFR 126.203 - What size standards apply to HUBZone SBCs?

    Science.gov (United States)

    2010-01-01

    ... PROGRAM Requirements to be a Qualified HUBZone SBC § 126.203 What size standards apply to HUBZone SBCs? (a) At time of application for certification. A HUBZone SBC must meet SBA's size standards for its... concern is small, SBA may deny the concern status as a qualified HUBZone SBC, or SBA may request a...

  2. 10 CFR 9.203 - Procedure where response to demand is required prior to receiving instructions.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Procedure where response to demand is required prior to... or Disclosure in Response to Subpoenas or Demands of Courts or Other Authorities § 9.203 Procedure where response to demand is required prior to receiving instructions. If a response to the demand...

  3. 77 FR 48174 - Comment Request for Information Collection for the ETA 203, Characteristics of the Insured...

    Science.gov (United States)

    2012-08-13

    ... Employment and Training Administration Comment Request for Information Collection for the ETA 203... Administration (ETA), Labor. ACTION: Notice. SUMMARY: The Department of Labor (Department), as part of its... requirements on respondents can be properly assessed. Currently, ETA is soliciting comments concerning...

  4. 29 CFR 780.203 - Performance of operations on a farm but not by the farmer.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Performance of operations on a farm but not by the farmer... Operations § 780.203 Performance of operations on a farm but not by the farmer. Logging or sawmill operations on a farm undertaken on behalf of the farmer or on behalf of the buyer of the logs or the...

  5. 18 CFR 2.26 - Policies concerning review of applications under section 203.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Policies concerning review of applications under section 203. 2.26 Section 2.26 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES GENERAL POLICY...

  6. Basophil sensitivity through CD63 or CD203c is a functional measure for specific immunotherapy

    Directory of Open Access Journals (Sweden)

    Dahl Ronald

    2010-02-01

    Full Text Available Abstract Background Subcutaneous Immunotherapy (SCIT modifies the allergic response and relieves allergic symptoms. SCIT is the only and a very effective treatment for insect venom allergy. We hypothesized that basophil sensitivity, measured through the basophil activation test, would decrease during SCIT up dosing. Expression of CD203c was compared to CD63 as marker for basophil activation, using a Bland Altman plot and ROC curves. Methods Patients (n = 18 starting subcutaneous SCIT for wasp allergy with an up dosing scheme of 7 to 11 weeks were enrolled. Heparinised blood samples were drawn at weeks 1-4, 7 and at the first maintenance visit. Basophils were stimulated at 7 log dilutions of V. vespula allergen for 15 min, and were stained with CD203c and CD63. Basophils were identified as CD203c+ leukocytes, and the proportion of CD63+ and CD203c+ cells were plotted against allergen concentration. A sigmoid curve was fitted to the points, and the allergen concentration at which half of the maximal activation was achieved, LC50, was calculated. In another series of experiments, LC50 calculated in whole blood (AP was subtracted from LC50 calculated with basophils suspended in plasma from a nonatopic donor (HS to determine the protective effect of soluble factors in blood of patients treated with SCIT. Results Heparin blood basophil activation was similar through CD63 and CD203c. Basophils were significantly more sensitized three weeks after initiation of SCIT compared to baseline (p Conclusion Basophil activation is a versatile and sensitive tool that measures changes in the humoral immune response to allergen during SCIT.

  7. Mercury 203 distribution in pregnant and nonpregnant rats following systemic infusions with thiol-containing amino acids

    Energy Technology Data Exchange (ETDEWEB)

    Aschner, M.; Clarkson, T.W.

    1987-12-01

    Near-term pregnant (gestational day 17) and nonpregnant Long-Evans female rats were continuously infused into the external jugular vein with 0.1 mmole/hour L-cysteine, 0.1 mmole/hour L-leucine, or saline. At 24, 48, and 72 hours, 50 mumole/hour (/sup 203/Hg)-MeHgCl was administered over 1 hour. Total /sup 203/Hg body burden, brain, kidney, liver, and blood /sup 203/Hg concentrations were determined at 96 hours by gamma scintillation spectrometry. Despite significantly greater /sup 203/Hg whole body retention in the pregnant animals /sup 203/Hg concentrations in blood, brain, kidney, and liver were higher in nonpregnant rats. In addition, brain /sup 203/Hg concentrations in both pregnant and virgin rats were significantly higher in L-cysteine-treated rats compared with controls. These results suggest that the fetus may act as a sink for MeHg, thus decreasing /sup 203/Hg concentrations in maternal blood, brain, kidney, and liver. Furthermore, the data indicate that brain uptake of methylmercury in both pregnant and nonpregnant rats is enhanced by chronic L-cysteine infusion, lending support to the hypothesis that methylmercury in the rat may be translocated across the blood-brain barrier by the neutral amino acid carrier transport system.

  8. Cyclophilin 20-3 relays a 12-oxo-phytodienoic acid signal during stress responsive regulation of cellular redox homeostasis.

    Science.gov (United States)

    Park, Sang-Wook; Li, Wei; Viehhauser, Andrea; He, Bin; Kim, Soonok; Nilsson, Anders K; Andersson, Mats X; Kittle, Joshua D; Ambavaram, Madana M R; Luan, Sheng; Esker, Alan R; Tholl, Dorothea; Cimini, Daniela; Ellerström, Mats; Coaker, Gitta; Mitchell, Thomas K; Pereira, Andy; Dietz, Karl-Josef; Lawrence, Christopher B

    2013-06-04

    The jasmonate family of phytohormones plays central roles in plant development and stress acclimation. However, the architecture of their signaling circuits remains largely unknown. Here we describe a jasmonate family binding protein, cyclophilin 20-3 (CYP20-3), which regulates stress-responsive cellular redox homeostasis. (+)-12-Oxo-phytodienoic acid (OPDA) binding promotes CYP20-3 to form a complex with serine acetyltransferase 1, which triggers the formation of a hetero-oligomeric cysteine synthase complex with O-acetylserine(thiol)lyase B in chloroplasts. The cysteine synthase complex formation then activates sulfur assimilation that leads to increased levels of thiol metabolites and the buildup of cellular reduction potential. The enhanced redox capacity in turn coordinates the expression of a subset of OPDA-responsive genes. Thus, we conclude that CYP20-3 is a key effector protein that links OPDA signaling to amino acid biosynthesis and cellular redox homeostasis in stress responses.

  9. Navier-Stokes solution on the CYBER-203 by a pseudospectral technique

    Science.gov (United States)

    Lambiotte, J. J.; Hussaini, M. Y.; Bokhari, S.; Orszag, S. A.

    A three-level, time-split, mixed spectral/finite difference method for the numerical solution of the three-dimensional, compressible Navier-Stokes equations has been developed and implemented on the Control Data Corporation (CDC) CYBER-203. This method uses a spectral representation for the flow variables in the streamwise and spanwise coordinates, and central differences in the normal direction. The five dependent variables are interleaved one horizontal plane at a time and the array of their values at the grid points of each horizontal plane is a typical vector in the computation. The code is organized so as to require, per time step, a single forward-backward pass through the entire data base. The one-and two-dimensional Fast Fourier Transforms are performed using software especially developed for the CYBER-203.

  10. /sup 203/Hg and other gamma-emitting radio-isotopes as labels for Dirofilaria immitis microfilariae

    Energy Technology Data Exchange (ETDEWEB)

    Lengemann, F.W.; Grieve, R.B.; Chmielewicz, M.; Georgi, J.R.

    1986-04-01

    The in vitro uptake of gamma-emitting radionuclides by microfilariae of Dirofilaria immitis was investigated. Radionuclides tested were /sup 133/Ba, /sup 207/Bi, /sup 82/Br, /sup 109/Cd, /sup 51/Cr, /sup 60/Co, /sup 59/Fe, /sup 203/Hg, /sup 125/I, /sup 54/Mn, /sup 32/P, /sup 125/Sb, /sup 46/Sc, /sup 75/Se and /sup 65/Zn. Only /sup 207/Bi, /sup 59/Fe, /sup 203/Hg, /sup 54/Mn and /sup 46/Sc showed more than 2% of the available radioactivity to bind to the microfilariae. When tested for retention in vitro only /sup 203/Hg showed retention levels approaching 90%. Moreover, when dimethyl-sulphoxide was incorporated into the medium at levels of 1% (v/v) the uptake of /sup 203/Hg could be increased by 3-5 times; no other radio-isotope tested responded in this manner. The uptake of /sup 203/Hg was directly related to temperature and time of incubation. Mercury, as mercuric chloride, was toxic to the microfilariae and represents an impediment to the incorporation of high levels of /sup 203/Hg in microfilariae.

  11. Clinical features of 203 infants with pulmonary tuberculosis%婴儿肺结核203例临床特征分析

    Institute of Scientific and Technical Information of China (English)

    龚春竹; 朱朝敏

    2014-01-01

    Objectives To summarize the clinical features and relevant factors of 203 cases with infantile pulmonary tuberculosis. Methods Clinical data of 203 infantile with pulmonary tuberculosis were retrospectively reviewed. Results Among 203 infants, 127 (62.6%) were from country, 76 (37.4%) from city;64.5%of city infants have received BCG vaccination, which is higher than 46.5%in country infants;78 cases (38.4%) have clear evidence for active tuberculosis exposure, 26 cases (12.8%) have suspicious tuberculosis exposure;175 cases (86.2%) have fever, 165 cases (81.3%) have respiratory symptoms, 107 cases (52.7%) have pulmonary signs, 80 cases (39.4%) have hepatosplenomegaly;Etiology was conifrmed in 91 cases (44.8%);54.7%of patients were found with concurrent extrapulmonary tuberculosis, and the most commonly seen was formis tuberculous meningitis. In this study, the misdiagnosis rate is 39.9%, and 84.0%patients were often misdiagnosed as bronchial pneumonia;Vaccinated BCG rate is lower in infants with severe tuberculosis (44.83%) than that of infants with mild tuberculosis (74.14%). Conclusions Infantile pulmonary tuberculosis is featured with acute onset, severe clinical performance and easily complicated with extrapulmonary tuberculosis, atypical clinical performance, and high misdiagnosed rate which needs early detection and diagnosis. Unvaccinated BCG and active tuberculosis exposure were important clues for the diagnosis of infantile pulmonary tuberculosis.%目的:总结分析婴儿肺结核的临床特点及相关因素。方法回顾性分析2001年至2011年收治的203例婴儿肺结核的临床资料。结果203例住院肺结核患儿中,来自农村127例(62.56%),城市76例(37.44%);城市患儿BCG接种率(64.47%)高于农村(46.46%),差异有统计学意义(P<0.05)。有明确活动性肺结核接触史78例(38.42%),可疑结核接触史26例(12.81%);临床表现发热175例(86.21%),呼吸道症状165例(81.28%),有肺部体征107例(52

  12. Tank 241-T-203, core 190 analytical results for the final report

    Energy Technology Data Exchange (ETDEWEB)

    Steen, F.H.

    1997-08-05

    This document is the analytical laboratory report for tank 241-T-203 push mode core segments collected on April 17, 1997 and April 18, 1997. The segments were subsainpled and analyzed in accordance with the Tank 241-T-203 Push Mode Core Sampling andanalysis Plan (TSAP) (Schreiber, 1997a), the Safety Screening Data Quality Objective (DQO)(Dukelow, et al., 1995) and Leffer oflnstructionfor Core Sample Analysis of Tanks 241-T-201, 241-T-202, 241-T-203, and 241-T-204 (LOI)(Hall, 1997). The analytical results are included in the data summary report (Table 1). None of the samples submitted for Differential Scanning Calorimetry (DSC), Total Alpha Activity (AT) and Total Organic Carbon (TOC) exceeded notification limits as stated in the TSAP (Schreiber, 1997a). The statistical results of the 95% confidence interval on the mean calculations are provided by the Tank Waste Remediation Systems (TWRS) Technical Basis Group in accordance with the Memorandum of Understanding (Schreiber, 1997b) and not considered in this report.

  13. Development of the Separation System of {sup 203}Tl Stable Isotope

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Do Young; Ko, Kwang Hoon; Lim, Gwon; Kim, Tak Soo; Park, Hyun Min; Rho, Si Pyo; Kim, Cheol Jung [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2005-07-01

    Thallium has two naturally occurring isotopes, {sup 203}Tl and {sup 205}Tl, with abundances of 30% and 70%, respectively. {sup 203}Tl is an indispensable raw material for the production of {sup 201}Tl radioisotopes by a proton bombardment in a cyclotron. {sup 201}TlCl is a radiopharmaceutical used widely to diagnose a heart disease. Development of the isotope-selective photoionization technique of Tl has been attractive, but an isotope selective ionization of thallium has never been achieved so far because of its small isotope shift as well as the lack of an available autoionization state. We have proposed a new method to separate the thallium isotopes, which is based-on an isotope-selective optical pumping followed by infrared photoionization. Many photoionization methods are available, such as the two photon excitation followed by the direct ionization in a high electric field. But, other ionization methods do not have the sufficient selectivity for a single stage. Two or three stages have to be applied for obtaining the sufficient selectivity. Moreover, they need strict experimental conditions and are expected that the efficiency decreases in the ionization step. However, our method is expected to overcome these drawbacks. With this background, we developed the laser isotope separation system to have high isotopic abundance of {sup 203}Tl. The system configuration and characteristics are represented in this paper.

  14. Morphology and Frictional Characteristics Under Electrical Currents of Al203/Cu Composites Prepared by Internal Oxidation

    Institute of Scientific and Technical Information of China (English)

    Liu Ruihua; Song Kexing; Jia Shuguo; Xu Xiaofeng; Gao Jianxin; Guo Xiuhua

    2008-01-01

    Two AhO3/Cu composites containing 0.24 wt.% A1203 and 0.60 wt.% A1203 separately are prepared by internal oxidation.Effectsof sliding speed and pressure on the fi-ictional characteristics of the composites and copper against brass are investigated and compared.The changes in morphology of the sliding surface and subsurface are examined with scanning electron microscope (SEM) and energy dispersive X-ray spectrum (EDS).The results show that the wear resistance of the AI203/Cu composites is superior to that of copperunder the same conditions.Under a given electrical current,the wear rate of AI203/Cu composites decreases as the AleO3-content increases.However,the wear rates of the Al203/Cu composites and copper increase as the sliding speed and pressure increase under drysliding condition.The main wear mechanisms for AleO3/Cu composites are of abrasion and adhesion;for copper,it is adhesion,although wear by oxidation and electrical erosion can also be observed as the speed and pressure rise.

  15. The expression and clinical significance of miR-203 in pediatric acute leukemia%miR-203在儿童急性白血病患者中的表达及其临床意义

    Institute of Scientific and Technical Information of China (English)

    王娜; 潘健; 曹岚; 卢俊; 肖佩芳; 赵文理; 胡绍燕; 柴忆欢

    2013-01-01

    目的 检测miR-203在儿童急性白血病患者中的甲基化状态及表达情况,探讨其临床意义.方法 应用甲基化特异性聚合酶链反应检测miR-203启动子区CpG岛的甲基化状态,用实时荧光定量聚合酶链反应检测miR-203的相对表达量,分析其与临床指标间的关系.结果 31例儿童急性淋巴细胞白血病(ALL)、15例儿童急性髓系白血病(AML)及23份非恶性血液病患儿骨髓标本(对照组)均未检测到miR-203的甲基化现象.miR-203在对照组、儿童急性白血病组、ALL组及AML组的相对表达量分别为16.93±6.31、48.97±10.38、55.88±12.91、24.28±9.10,儿童急性白血病组、ALL组与对照组相比,差异有统计学意义(P值分别为0.011和0.009),儿童AML组与对照组相比,差异无统计学意义(P=0.514).各项临床指标中,miR-203的表达与初诊ALL患儿的性别、免疫分型、染色体核型、是否检出融合基因、BCR-ABL基因表达、SIL-TAL1基因表达、泼尼松试验及急性白血病患儿的性别、染色体核型、是否检出融合基因、SIL-TAL1基因表达相关(P值均<0.05).其中在ALL危险度分组两两比较中,中危组与高危组两组间miR-203的表达差异有统计学意义(P=0.022).结论 miR-203在大部分急性白血病患儿中不受甲基化机制调控.miR-203可能作为原癌基因参与儿童急性白血病尤其是ALL的形成.miR-203的高表达可能与急性白血病患儿尤其是ALL患儿的不良预后相关.%Objective To investigate the methylation,expression and clinical significance of miR-203 in pediatric acute leukemia.Methods The methylation status of miR-203 promoter CpG islands was detected with methylation-specific polymerase chain reaction.The expression of miR-203 was detected by Taqman real-time quantitative polymerase chain reaction.And the clinical significance of miR-203 in pediatric acute leukemia (ALL) was also analyzed.Results The promoter of miR-203 was unmethylated in all of 31

  16. Down regulation of miR-203 in radiation-induced thymic lymphoma promoted cells proliferation and inhibited apoptosis%Down regulation of miR-203in radiation-induced thymic lymphoma promoted cells proliferation and inhibited apoptosis

    Institute of Scientific and Technical Information of China (English)

    Zhang Chaoxiong; Zhang Mingjian; Gao Fu; Zhou Chuanfeng; Zhang Pei; Cai Jianming; Liu Cong

    2015-01-01

    Objective To investigate the role of miR-203 in radiation-induced thymic lymphoma (RITL).Methods A 60Co irradiator was used for total-body irradiation.MicroRNAs(miRNAs) level was assayed by qRT-PCR.Cell proliferation was assayed by MTT assay.Cell apoptosis was examined by fluorescence activated cell sorter (FACS).Dual luciferase reporter assay system was used to detect the 3'UTR reporter.Results MiR-203 was down-regulated in RITL tissues.Overexpression of miR-203 strongly inhibited the proliferation of both NIH3T3 cells and EL4 cells and vice versa.MiR-203 inhibited cells proliferation and induced apoptosis via TANK-binding kinase (TBK1),SLUG (SNAI2) and Cyclin D1 (CCND1).Conclusions Radiation down-regulated the level of miR-203 in thymic,which promoted radiation-induced thymic lymphoma by targeting TBK1,SNAI2 and CCND1.

  17. CYP7A1 promoter polymorphism -203A>C affects bile salt synthesis rate in patients after ileal resection.

    Science.gov (United States)

    Lenícek, Martin; Komárek, Viktor; Zimolová, Miluse; Kovár, Jan; Jirsa, Milan; Lukás, Milan; Vítek, Libor

    2008-12-01

    Cholesterol 7alpha-hydroxylase (CYP7A1) plays a crucial role in cholesterol metabolism and has been implicated in genetic susceptibility to atherosclerosis. Thus, an understanding of its transcriptional regulation is of considerable importance. We evaluated the effect of a common -203A>C polymorphism in the CYP7A1 promoter region on the activity of CYP7A1, estimated as the ratios of serum 7alpha-hydroxycholest-4-en-3-one (C4) to either total or non-HDL-cholesterol. The study was performed on patients after resection of the distal ileum, leading to upregulation of CYP7A1 activity (n = 65). Healthy volunteers served as the control group (n = 66). Whereas higher CYP7A1 activity was associated with the -203A allele in the patient group (C4/cholesterol ratio, 29.0 vs. 14.8 microg/mmol, P = 0.032; C4/non-HDL-cholesterol ratio, 53.3 vs. 21.3 microg/mmol in -203AA and -203CC, P = 0.017, respectively), no differences were observed in the healthy controls. We conclude that under physiological conditions, the -203A>C polymorphism in the CYP7A1 gene promoter region does not seem to have any clinically relevant effect. However, in patients with severe bile salt malabsorption, this polymorphism markedly affects CYP7A1 activity.

  18. 30 CFR 203.71 - How does MMS allocate a field's suspension volume between my lease and other leases on my field?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How does MMS allocate a field's suspension volume between my lease and other leases on my field? 203.71 Section 203.71 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT RELIEF OR REDUCTION IN ROYALTY RATES OCS Oil, Gas, and Sulfur...

  19. 25 CFR 162.203 - When can the regulations in this subpart be superseded or modified by tribal laws and leasing...

    Science.gov (United States)

    2010-04-01

    ... modified by tribal laws and leasing policies? 162.203 Section 162.203 Indians BUREAU OF INDIAN AFFAIRS... When can the regulations in this subpart be superseded or modified by tribal laws and leasing policies... resolution establishing a general policy for the leasing of tribal and individually-owned agricultural...

  20. 30 CFR 203.32 - What other requirements or restrictions apply to royalty relief for a qualified phase 2 or phase...

    Science.gov (United States)

    2010-07-01

    ... REDUCTION IN ROYALTY RATES OCS Oil, Gas, and Sulfur General Royalty Relief for Drilling Ultra-Deep Wells on... qualified ultra-deep well is a directional well (either an original well or a sidetrack) drilled across a... to royalty relief for a qualified phase 2 or phase 3 ultra-deep well? 203.32 Section 203.32...

  1. 30 CFR 203.40 - Which leases are eligible for royalty relief as a result of drilling a deep well or a phase 1...

    Science.gov (United States)

    2010-07-01

    ... REDUCTION IN ROYALTY RATES OCS Oil, Gas, and Sulfur General Royalty Relief for Drilling Deep Gas Wells on... a result of drilling a deep well or a phase 1 ultra-deep well? 203.40 Section 203.40 Mineral... a result of drilling a deep well or a phase 1 ultra-deep well? Your lease may receive an RSV...

  2. 30 CFR 203.30 - Which leases are eligible for royalty relief as a result of drilling a phase 2 or phase 3 ultra...

    Science.gov (United States)

    2010-07-01

    ... ROYALTY RATES OCS Oil, Gas, and Sulfur General Royalty Relief for Drilling Ultra-Deep Wells on Leases Not... a result of drilling a phase 2 or phase 3 ultra-deep well? 203.30 Section 203.30 Mineral Resources... drilling a phase 2 or phase 3 ultra-deep well? Your lease may receive a royalty suspension volume...

  3. 30 CFR 203.34 - To which production may an RSV earned by qualified phase 2 and phase 3 ultra-deep wells on my...

    Science.gov (United States)

    2010-07-01

    ... REDUCTION IN ROYALTY RATES OCS Oil, Gas, and Sulfur General Royalty Relief for Drilling Ultra-Deep Wells on...) To production from a deep well or ultra-deep well that commenced drilling before: (1) March 26, 2003... qualified phase 2 and phase 3 ultra-deep wells on my lease not be applied? 203.34 Section 203.34...

  4. 48 CFR 203.104-4 - Disclosure, protection, and marking of contractor bid or proposal information and source...

    Science.gov (United States)

    2010-10-01

    ..., and marking of contractor bid or proposal information and source selection information. 203.104-4....104-4 Disclosure, protection, and marking of contractor bid or proposal information and source selection information. (d)(3) For purposes of FAR 3.104-4(d)(3) only, DoD follows the...

  5. 21 CFR 203.36 - Fulfillment houses, shipping and mailing services, comarketing agreements, and third-party...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Fulfillment houses, shipping and mailing services... Samples § 203.36 Fulfillment houses, shipping and mailing services, comarketing agreements, and third... manufacturer or authorized distributor of record that uses a fulfillment house, shipping or mailing service,...

  6. miR-203在前列腺癌中的表达及其与预后的相关性%Expression of miR-203 in prostate carcinoma and its correlation with prognosis

    Institute of Scientific and Technical Information of China (English)

    肖虹; 郑绘霞; 阴琰; 李宁; 武丽娜; 梁钢; 赵杨璐; 程彩霞; 梁建芳

    2013-01-01

    Objective To explore the expression of miR-203 in prostate carcinoma (PCa) and its correlation with clinicopathological factors and the patients’ prognosis.Methods The expression of miR-203 in 30 cases of PCa and 10 cases of benign prostatic hyperplasia (BPH) were detected by using real-time PCR.Kaplan-Meier and multivariate Cox proportional hazards regression model analysis were applied to compare the survival curves and screen the independent prognosis factors respectively.Results Between the PCa and BPH tissues,there were significant differences in the expression of miR-203 (P < 0.05).With Gleason score getting higher,the levels of miR-203 expression were up-regulated gradually 2 times.Gleason grading > 7 scores vs BPH,Gleasen grading 9-10 scores vs BPH,Gleason grading 7-8 scores vs 7 scores,Gleason grading 9-10 scores vs < 7 scores,the levels of miR-203 expression were up-regulated 2.8,3.1,2.7,2.9 times (all P < 0.05).Moreover,this elevation correlated with Gleason grading,clinical staging and bone metastasis.Furthermore,the survival time was decreased in patients with higher expression levels of miR-203 (P < 0.05).Conclusion Aberrant miRNA expression is partially associated with enhanced malignant degrees and poor prognosis in prostate tumorigenesis.The marker could be applied to indicate the malignant degrees and evaluate the patients’ prognosis.%目的 探讨miR-203在前列腺癌组织中的表达及其与前列腺癌临床病理特征和患者预后的关系.方法 应用实时荧光定量反转录PCR检测30例前列腺癌和10例前列腺良性增生组织中miR-203的表达,应用Kaplan-Meier生存曲线分析miR-203与患者预后的关系,多变量Cox比例风险回归模型筛选影响患者生存的独立预后因素.结果 miR-203在前列腺癌组织中表达较良性增生组织增高,差异有统计学意义(P<0.05),Gleason积分>7分者较<7分者miR-203表达量增高了约2倍;Gleason积分7~8分与前

  7. miR-203 and miR-205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma.

    Science.gov (United States)

    Cañueto, J; Cardeñoso-Álvarez, E; García-Hernández, J L; Galindo-Villardón, P; Vicente-Galindo, P; Vicente-Villardón, J L; Alonso-López, D; De Las Rivas, J; Valero, J; Moyano-Sáez, E; Fernández-López, E; Mao, J H; Castellanos-Martín, A; Román-Curto, C; Pérez-Losada, J

    2016-12-11

    Cutaneous squamous cell carcinoma is the second most widespread cancer in humans and its incidence is rising. These tumours can evolve as poor-prognosis diseases, and therefore it is important to identify new markers to better predict its clinical evolution. Here, we identified the expression pattern of miRNAs at different stages of skin cancer progression in a panel of murine skin cancer cell lines. We determined that miR-203 and miR-205 are differentially expressed in this panel, and evaluated their potential use as biomarkers of prognosis in human tumours. MiR-205 was expressed in tumours with pathological features recognized as indicators of poor prognosis such as desmoplasia, perineural invasion and infiltrative growth pattern. MiR-205 was mainly expressed in undifferentiated areas and in the invasion front, and was associated with both local recurrence and the development of general clinical events of poor evolution. MiR-205 expression was an independent variable selected to predict events of poor clinical evolution using the multinomial logistic regression model described in this study. In contrast, miR-203 was mainly expressed in tumours exhibiting the characteristics associated with a good prognosis, was mainly present in well-differentiated zones, and rarely expressed in the invasion front. Therefore, the expression and associations of miR-205 and miR-203 were mostly mutually exclusive. Finally, using a logistic biplot we identified three clusters of patients with differential prognosis based on miR-203 and miR-205 expression, and pathological tumour features. This work highlights the utility of miRNA-205 and miRNA-203 as prognostic markers in cutaneous squamous cell carcinoma. This article is protected by copyright. All rights reserved.

  8. Hypersonic characteristics of an advanced aerospace plane at Mach 20.3

    Science.gov (United States)

    Mccandless, R. S.

    1985-01-01

    Wind-tunnel studies have been performed in the Langley Hypersonic Helium Tunnel Facility to obtain static longitudinal and lateral-directional aerodynamic characteristics of an advanced aerospace plane concept. The nominal test conditions are a Mach number of 20.3 and a Reynolds number of 6.8 x 10 to the 6th power per foot at angles of attack from 0 to 25 deg and angles of sideslip of -3 and 0 deg. Stability and control characteristics are obtained for several deflections of the elevators, elevons, and rudder. In addition, a modified canopy is examined. The results indicate that this vehicle is longitudinally stable at angles of attack near the maximum lift-drag ratio. Also, the vehicle is shown to be directionally unstable with positive dihedral effect.

  9. A catalog of 203 galaxy clusters serendipitously detected in the ROSAT PSPC pointed observations

    DEFF Research Database (Denmark)

    Vikhlinin, A.; McNamara, B.R.; Forman, W.;

    1998-01-01

    We present a catalog of 203 clusters of galaxies serendipitously detected in 647 ROSAT PSPC high Galactic latitude pointings covering 158 deg(2). This is one of the largest X-ray-selected cluster samples, comparable in size only to the ROSAT All-Sky Survey sample of nearby clusters (Ebeling et al......), corresponding to very poor groups, to similar to 5 x 10(44) ergs s(-1), corresponding to rich clusters. The cluster redshifts range from z = 0.015 to z > 0.5. The catalog lists X-ray fluxes, core radii, and spectroscopic redshifts for 73 clusters and photometric redshifts for the remainder. Our detection method...... confirmed clusters. The number of false detections and their flux distribution are in perfect agreement with simulations. The log N-log S relation for clusters derived from our catalog shows excellent agreement with counts of bright clusters derived from the Einstein Extended Medium Sensitivity Survey...

  10. Direct cell fate conversion of human somatic stem cells into cone and rod photoreceptor-like cells by inhibition of microRNA-203.

    Science.gov (United States)

    Choi, Soon Won; Shin, Ji-Hee; Kim, Jae-Jun; Shin, Tae-Hoon; Seo, Yoojin; Kim, Hyung-Sik; Kang, Kyung-Sun

    2016-07-05

    Stem cell-based photoreceptor differentiation strategies have been the recent focus of therapies for retinal degenerative diseases. Previous studies utilized embryonic stem (ES) cells and neural retina differentiation cocktails, including DKK1 and Noggin. Here, we show a novel microRNA-mediated strategy of retina differentiation from somatic stem cells, which are potential allogeneic cell sources. Human amniotic epithelial stem cells (AESCs) and umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) treated with a retina differentiation cocktail induced gene expressions of retina development-relevant genes. Furthermore, microRNA-203 (miR-203) is abundantly expressed in human AESCs and human UCB-MSCs. This miR-203 is predicted to target multiple retina development-relevant genes, particularly DKK1, CRX, RORβ, NEUROD1, NRL and THRB. The inhibition of miR-203 induced a retina differentiation of AESCs and UCB-MSCs. Moreover, successive treatments of anti-miR-203 led to the expression of both mature photoreceptor (PR) markers, rhodopsin and opsin. In addition, we determined that CRX, NRL and DKK1 are direct targets of miR-203 using a luciferase assay. Thus, the work presented here suggests that somatic stem cells can potentially differentiate into neural retina cell types when treated with anti-miR-203. They may prove to be a source of both PR subtypes for future allogeneic stem cell-based therapies of non-regenerative retina diseases.

  11. Biodistribution and radiation dosimetry of a positron emission tomographic ligand, {sup 18}F-SP203, to image metabotropic glutamate subtype 5 receptors in humans

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Yasuyuki; Simeon, Fabrice G.; Pike, Victor W.; Innis, Robert B.; Fujita, Masahiro [National Institute of Mental Health, Molecular Imaging Branch, Bethesda, MD (United States); Hatazawa, Jun [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Suita, Osaka (Japan); Mozley, P.D. [Merck Research Laboratories, West Point, PA (United States)

    2010-10-15

    A new PET ligand, 3-fluoro-5-(2-(2-{sup 18}F-(fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ({sup 18}F-SP203), is a positron emission tomographic radioligand selective for metabotropic glutamate subtype 5 receptors. The purposes of this study were to estimate the radiation-absorbed doses of {sup 18}F-SP203 in humans and to determine from the distribution of radioactivity in bone structures with various proportions of bone and red marrow whether {sup 18}F-SP203 undergoes defluorination. Whole-body images were acquired for 5 h after injecting {sup 18}F-SP203 in seven healthy humans. Urine was collected at various time points. Radiation-absorbed doses were estimated by the Medical Internal Radiation Dose scheme. After injecting {sup 18}F-SP203, the two organs with highest radiation exposure were urinary bladder wall and gallbladder wall, consistent with both urinary and fecal excretion. In the skeleton, most of the radioactivity was in bone structures that contain red marrow and not in those without red marrow. Although the dose to red marrow (30.9 {mu}Sv/MBq) was unusually high, the effective dose (17.8 {mu}Sv/MBq) of {sup 18}F-SP203 was typical of that of other {sup 18}F radiotracers. {sup 18}F-SP203 causes an effective dose in humans typical of several other {sup 18}F radioligands and undergoes little defluorination. (orig.)

  12. Expressions of CD63 and CD203c in basophils of allergic asthma patients%过敏性哮喘患者嗜碱粒细胞CD63和CD203c的表达

    Institute of Scientific and Technical Information of China (English)

    杨玲; 李强; 王树云; 许以平; 郭胤仕; 姚迪; 史桂英

    2012-01-01

    目的:探讨过敏性哮喘患者嗜碱粒细胞激活后其CD63和CD203c的表达情况.方法:采用流式细胞术检测过敏性哮喘(哮喘组)、非过敏性哮喘患者(非过敏性哮喘组)及正常对照者(正常对照组)的血嗜碱性粒细胞中CD63和CD203c的表达,并进行比较.结果:以CD123和人类白细胞抗原DR联合设门,可观察到外周血中的嗜碱性粒细胞.与非过敏性哮喘组及正常对照组比较,过敏性哮喘组患者的血嗜碱粒细胞CD63荧光强度显著增加(P<0.01).经粉尘螨刺激后,与刺激前对照、非过敏性哮喘者及正常对照者比较,过敏性哮喘患者的血嗜碱粒细胞CD203c和CD63荧光强度均显著增加(P<0.01).嗜碱粒细胞CD203c、CD63表达程度与皮试结果及特异性IgE水平间均存在不同程度的相关性.受试者工作特征曲线分析结果显示,嗜碱粒细胞活化试验的曲线下面积为0.923,高于特异性IgE的曲线下面积(0.876).结论:采用流式细胞术检测CD63表达来确定活化嗜碱粒细胞是诊断过敏性疾病的一种安全、有效的体外检测方法.%Objective To study the expressions of CD63 and CD203c in activated basophils of patients with allergic asthma. Methods Flow cytometry (FCM) was used to measure the expressions of CD63 and CD203c in blood basophils of allergic asthma patients, non-allergic asthma patients and normal controls, and the results were compared. Results Peripheral blood basophils could be selected by using CD 123 and HLA-DR as the gate. The median fluorescence intensity (MFI) of CD63 in basophils of allergic asthma patients increased markedly when compared with that of non-allergic asthma patients and normal controls (P<0.01). After stimulated with dust mites, the median fluorescence intensity of CD203c and CD63 in basophils of allergic asthma patients increased significantly when compared with that before stimulation and that of non-allergic asthma patients and normal controls (P<0.01). The

  13. 不同栽培方式下香型优质稻渝香203的产量分析%Analysis of High-quality Rice Yuxiang 203 Yields under Different Planting Patterns

    Institute of Scientific and Technical Information of China (English)

    张现伟; 李经勇; 唐永群; 姚雄

    2011-01-01

    [Objective] The aim was to study the yields of Yuxiang203 in different planting patterns, discuss the better planting pattern to obtain the larger yields. [ Method] The differences of yield and its related characters were studied under 4 planting patterns, hand transplanting,machine transplanting, seedling throwing, direct sowing. [Result] The results showed that the yield performances of Yuxiang203 under 4 planting patterns were as follows:hand transplanting > machine transplanting > seedling throwing > direct sowing. [Conclusion] Four planting and cultivation patterns have their respective advantages and disadvantages. Thereinto, hand transplanting' yield is the biggest, but it has the disadvantage of big labor intensity and high planting cost. Machine transplanting and seedling throwing replace hand transplanting gradually.%[目的]研究不同栽培方式下优质稻渝香203的产量差异,探讨挖掘品种的高产潜力的栽培技术.[方法]研究手栽秧、机栽秧、抛秧、直播4种栽培方式下渝香203产量及相关性状的差异.[结果]手栽秧种植方式下产量最高,之后依次为机栽秧、抛秧,直播栽培方式下产量最低.[结论]4种栽培方式有各自的优缺点.其中手栽秧产量水平最高,但其劳动强度大,种植成本高;机插秧和抛秧正逐渐取代手插秧.

  14. Research on functions and mechanisms of MicroRNA-203 on migration of human hypopharyngeal carcinoma cells%MicroRNA-203对人下咽癌细胞转移能力的影响及其机制研究

    Institute of Scientific and Technical Information of China (English)

    高丽; 卞卡

    2015-01-01

    目的:研究MicroRNA-203对人下咽癌细胞迁移能力的影响及作用机理。方法利用生物信息学方法预测Mi-croRNA-203的下游调控靶分子,利用荧光素酶报告基因实验、qRT-PCR、与Westenr blot等方法对其中与调节细胞迁移有关的靶分子MEKK1进行验证,证实下咽癌细胞中MEKK1的表达是否受MicroRNA-203的影响。通过细胞迁移实验研究MicroRNA-203对下咽癌细胞迁移能力的影响,进一步阐明可能影响下咽癌转移能力的因素。结果在过表达MicroRNA-203的下咽癌细胞中,Westenr blot检测靶基因蛋白表达量分析、qRT-PCR检测靶基因mRNA表达量和双荧光素酶报告基因实验结果均提示MicroRNA-203下调靶基因MEKK1的表达。细胞迁移实验证明过表达MicroRNA-203可显著抑制下咽癌细胞的迁移能力。结论 MEKK1是MicroR-NA-203的直接下游作用靶点,MicroRNA-203有可能通过负向调控MEKK1抑制下咽癌细胞的转移能力。%Objective To determine the roles and underlying molecular mechanism of MicroRNA-203 on the migration of human hypo-pharyngeal carcinoma cells. Methods The potential MicroRNA-203 target genes were searched by bioinformatic miRNA target prediction tools and KEGG database,and a large number of candidates was identified. The MEKK1 was selected for further investigation. This gene is known to play a role in tumor metastasis. The MicroRNA-203’s binding sites in MEKK1’s mRNA 3’UTR were analyzed by luciferase report-er assays. Nextly,the protein expression of MEKK1 in Fadu-Lv-MicroRNA-203 cells was determined by Western blot assay. The regulation of MEKK1’s mRNA expression by MicroRNA-203 was analyzed by qRT-PCR. Transwell cell migration assays were performed to confirm the im-pact of MicroRNA-203 on hypopharyngeal carcinoma metastasis. Results The expression level of endogenous MicroRNA-203 was negatively correlated with the mRNA and protein expression levels of MEKK1 in hypopharyngeal carcinoma cells

  15. 30 CFR 203.60 - Who may apply for royalty relief on a case-by-case basis in deep water in the Gulf of Mexico or...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who may apply for royalty relief on a case-by-case basis in deep water in the Gulf of Mexico or offshore of Alaska? 203.60 Section 203.60 Mineral... basis in deep water in the Gulf of Mexico or offshore of Alaska? You may apply for royalty relief...

  16. Redox-Dependent Conformational Dynamics of Decameric 2-Cysteine Peroxiredoxin and its Interaction with Cyclophilin 20-3.

    Science.gov (United States)

    Liebthal, Michael; Strüve, Marcel; Li, Xin; Hertle, Yvonne; Maynard, Daniel; Hellweg, Thomas; Viehhauser, Andrea; Dietz, Karl-Josef

    2016-07-01

    2-Cysteine peroxiredoxins (2-CysPrxs) switch between functions as a thiol peroxidase, chaperone, an interaction partner and possibly a proximity-based oxidase in a redox-dependent manner. In photosynthetic eukaryotes, 2-CysPrx localizes to the plastid, functions in the context of photosynthesis and enables an ascorbate peroxidase-independent water-water cycle for detoxifying H2O2 The high degree of evolutionary conservation of 2-CysPrx suggests that the switching is an essential characteristic and needed to transduce redox information to downstream pathways and regulation. The study aimed at exploring the dissociation behavior of 2-CysPrx and its interactions with cyclophilin depending on bulk phase conditions. Isothermal titration microcalorimetry (ITC), dynamic light scattering and size exclusion chromatography (SEC) proved the previously suggested model that reduced 2-CysPrx below a critical transition concentration (CTC) exists in its dimeric state, and above the CTC adopts the decameric state. The presence of cyclophilin 20-3 (Cyp20-3) affected the CTC of a 2-CysPrx decamer suggesting interaction which was further quantified by direct titration of 2-CysPrx with Cyp20-3, and in overlays. Finally catalytic inactivation assays showed the higher catalytic efficiency of 2-CysPrx at pH 8 compared with pH 7.2, but also revealed increased inactivation by hyperoxidation at pH 8. Interestingly, calculation of the average turnover number until inactivation gave rather similar values of 243 and 268 catalytic cycles at pH 8 and pH 7.2, respectively. These quantitative data support a model where 2-CysPrx and Cyp20-3, by interaction, form a redox-sensitive regulatory module in the chloroplast which is under control of the photosynthesis-linked stromal pH value, the redox state and additional stromal protein factor(s).

  17. Hanford Tanks 241-C-203 and 241-C-204: Residual Waste Contaminant Release Model and Supporting Data

    Energy Technology Data Exchange (ETDEWEB)

    Deutsch, William J.; Krupka, Kenneth M.; Lindberg, Michael J.; Cantrell, Kirk J.; Brown, Christopher F.; Schaef, Herbert T.

    2004-10-28

    This report describes the development of release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. Key results from this work are (1) future releases from the tanks of the primary contaminants of concern (99Tc and 238U) can be represented by relatively simple solubility relationships between infiltrating water and solid phases containing the contaminants; and (2) high percentages of technetium-99 in the sludges (20 wt% in C-203 and 75 wt% in C-204) are not readily water leachable, and, in fact, are very recalcitrant. This is similar to results found in related studies of sludges from Tank AY-102. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for the U.S. Department of Energy.

  18. Hanford Tanks 241-C-203 and 241 C 204: Residual Waste Contaminant Release Model and Supporting Data

    Energy Technology Data Exchange (ETDEWEB)

    Deutsch, William J.; Krupka, Kenneth M.; Lindberg, Michael J.; Cantrell, Kirk J.; Brown, Christopher F.; Schaef, Herbert T.

    2007-05-23

    This report was revised in May 2007 to correct 90Sr values in Chapter 3. The changes were made on page 3.9, paragraph two and Table 3.10; page 3.16, last paragraph on the page; and Tables 3.21 and 3.31. The rest of the text remains unchanged from the original report issued in October 2004. This report describes the development of release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. Key results from this work are (1) future releases from the tanks of the primary contaminants of concern (99Tc and 238U) can be represented by relatively simple solubility relationships between infiltrating water and solid phases containing the contaminants; and (2) high percentages of technetium-99 in the sludges (20 wt% in C-203 and 75 wt% in C-204) are not readily water leachable, and, in fact, are very recalcitrant. This is similar to results found in related studies of sludges from Tank AY-102. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for the U.S. Department of Energy.

  19. Maternal-fetal distribution of mercury ( sup 203 Hg) released from dental amalgam fillings

    Energy Technology Data Exchange (ETDEWEB)

    Vimy, M.J.; Takahashi, Y.; Lorscheider, F.L. (Univ. of Calgary, Alberta (Canada))

    1990-04-01

    In humans, the continuous release of Hg vapor from dental amalgam tooth restorations is markedly increased for prolonged periods after chewing. The present study establishes a time-course distribution for amalgam Hg in body tissues of adult and fetal sheep. Under general anesthesia, five pregnant ewes had twelve occlusal amalgam fillings containing radioactive 203Hg placed in teeth at 112 days gestation. Blood, amniotic fluid, feces, and urine specimens were collected at 1- to 3-day intervals for 16 days. From days 16-140 after amalgam placement (16-41 days for fetal lambs), tissue specimens were analyzed for radioactivity, and total Hg concentrations were calculated. Results demonstrate that Hg from dental amalgam will appear in maternal and fetal blood and amniotic fluid within 2 days after placement of amalgam tooth restorations. Excretion of some of this Hg will also commence within 2 days. All tissues examined displayed Hg accumulation. Highest concentrations of Hg from amalgam in the adult occurred in kidney and liver, whereas in the fetus the highest amalgam Hg concentrations appeared in liver and pituitary gland. The placenta progressively concentrated Hg as gestation advanced to term, and milk concentration of amalgam Hg postpartum provides a potential source of Hg exposure to the newborn. It is concluded that accumulation of amalgam Hg progresses in maternal and fetal tissues to a steady state with advancing gestation and is maintained. Dental amalgam usage as a tooth restorative material in pregnant women and children should be reconsidered.

  20. Scientific Opinion on Flavouring Group Evaluation 203, Revision 1 (FGE.203Rev1: α,β-Unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double-bonds and with or without additional non-conjugated double-bonds

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF

    2014-04-01

    Full Text Available The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of flavouring substances from subgroup 1.1.4 of FGE.19 in the Flavouring Group Evaluation 203, Revision 1 (FGE.203Rev1. The Flavour Industry has provided additional genotoxicity studies for one representative substance in FGE.203, namely 2,4-decadienal [FL-no: 05.140]. Based on the available data, on newly submitted studies and on the scientific evidence from the literature, the Panel concluded that the genotoxic potential cannot be ruled out for the flavouring substances in this FGE.

  1. Polymorphism of Gly482Ser PPARGC 1A and Ala203Pro PPARGC 1B in the pathogenesis of Graves’ orbitopathy

    Directory of Open Access Journals (Sweden)

    D M Serkin

    2015-06-01

    Full Text Available Aim. To examine the association of polymorphisms Gly482Ser PPARGC 1A and Ala203Pro PPARGC 1B with the development of thyroid eye disease (TEO. Materials and methods. A total of 88 people: 52 patients with TEO, 36 - healthy individuals. Identified polymorphisms Gly482Ser PPARGC 1A and Ala203Pro PPARGC 1B by PCR. Results. When TEO detected differences in the frequency of allele and genotype SNPs investigated compared with the control. The prevalence of genotypes and alleles in patients with TEO (Gly/Gly - 38.5%, Gly/Ser - 34.6%, Ser/Ser - 26.9%, Gly-allele - 55.8%, Ser-allele - 44.2% gene PPARGC 1A; Ala/Ala - 19.2%, Ala/Pro - 55.8%, Pro/Pro - 25%, Ala-allele - 47.1%, Pro-allele - 52.9% gene PPARGC 1B. The prevalence of genotypes and alleles in the control group (Gly/Gly - 38.9%, Gly/Ser - 44.4%, Ser/Ser - 16.7%, Gly-allele - 61.1%, Ser-allele - 38.9% of the gene PPARGC 1A; Ala/Ala - 25%, Ala/Pro - 58.3%, Pro/Pro - 16.7%, Ala-allele - 54.2%, Pro-allele - 45.8% of the gene PPARGC 1B. Conclusion. At TEO more common genotypes Ser482Ser PPARGC 1A, Pro203Pro PPARGC 1B and Ser allele polymorphism Gly482Ser PPARGC 1A, Pro polymorphism Ala203Pro PPARGC 1B, as well as less common genotypes Gly482Ser PPARGC 1A, Ala203Ala PPARGC 1B and Gly allele polymorphism Gly482Ser PPARGC 1A, Ala polymorphism Ala203Pro PPARGC 1B. Polymorphisms and allele Gly482Ser PPARGC 1A gene and gene Ala203Pro PPARGC 1B do not modify the risk of TEO.

  2. Physical activity in patients with axial spondyloarthritis: a cross-sectional study of 203 patients.

    Science.gov (United States)

    Fabre, Stéphanie; Molto, Anna; Dadoun, Sabrina; Rein, Christopher; Hudry, Christophe; Kreis, Sarah; Fautrel, Bruno; Pertuiset, Edouard; Gossec, Laure

    2016-12-01

    Physical activity is recommended in axial spondyloarthritis (axSpA) but may be insufficiently performed. The objective of this study was to assess physical activity in axial spondyloarthritis and to explore its explanatory factors. This was a cross-sectional study of patients with definite axSpA. The level of physical activity (International Physical Activity Questionnaire-Long form, IPAQ-L), type of aerobic exercise and the Exercise Benefits and Barriers Score were collected. Multivariate logistic regression analyses were performed to explain levels of exercise at least as recommended by the World Health Organization. In all, 203 patients were included: mean age 46.0 ± 11.6 years, 108 (53.2 %) males, mean Bath Ankylosing Spondylitis Activity Index (0-100) 37.8 ± 19.9; 137 (68.8 %) were treated with TNF-inhibitors. In all, 111 patients (54.7 %) were exercising at least as recommended; 96 (47.2 %) were in the 'high physical activity' category. Aerobic exercise >30 min was performed at least once a week by 61 (30.0 %) patients; the most frequent activities were energetic walking (31.0 %) and swimming (21.2 %). Main perceived benefits of exercising were improving physical fitness and functioning of the cardiovascular system, and the main barrier was physical exertion. Patients with paid employment had lower levels of physical activity whereas other demographic variables, disease activity/severity or TNF-inhibitor treatment were not predictive. One half of these patients performed enough physical activity according to the recommendations, similarly to the French population. Levels of physical activity did not appear to be explained by disease-related variables. Physical activity should be encouraged in axSpA.

  3. Synthesis and characterization in monkey of [{sup 11}C]SP203 as a radioligand for imaging brain metabotropic glutamate 5 receptors

    Energy Technology Data Exchange (ETDEWEB)

    Simeon, Fabrice G.; Liow, Jeih-San; Zhang, Yi; Hong, Jinsoo; Gladding, Robert L.; Zoghbi, Sami S.; Innis, Robert B.; Pike, Victor W. [National Institutes of Health, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD (United States)

    2012-12-15

    [{sup 18}F]SP203 (3-fluoro-5-(2-(2-([{sup 18}F]fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile) is an effective high-affinity and selective radioligand for imaging metabotropic 5 receptors (mGluR5) in human brain with PET. To provide a radioligand that may be used for more than one scanning session in the same subject in a single day, we set out to label SP203 with shorter-lived {sup 11}C (t{sub 1/2} = 20.4 min) and to characterize its behavior as a radioligand with PET in the monkey. Iodo and bromo precursors were obtained by cross-coupling 2-fluoromethyl-4-((trimethylsilyl)ethynyl)-1,3-thiazole with 3,5-diiodofluorobenzene and 3,5-dibromofluorobenzene, respectively. Treatment of either precursor with [{sup 11}C]cyanide ion rapidly gave [{sup 11}C]SP203, which was purified with high-performance liquid chromatography. PET was used to measure the uptake of radioactivity in brain regions after injecting [{sup 11}C]SP203 intravenously into rhesus monkeys at baseline and under conditions in which mGluR5 were blocked with 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP). The emergence of radiometabolites in monkey blood in vitro and in vivo was assessed with radio-HPLC. The stability of [{sup 11}C]SP203 in human blood in vitro was also measured. The iodo precursor gave [{sup 11}C]SP203 in higher radiochemical yield (>98 %) than the bromo precursor (20-52 %). After intravenous administration of [{sup 11}C]SP203 into three rhesus monkeys, radioactivity peaked early in brain (average 12.5 min) with a regional distribution in rank order of expected mGluR5 density. Peak uptake was followed by a steady decline. No radioactivity accumulated in the skull. In monkeys pretreated with MTEP before [{sup 11}C]SP203 administration, radioactivity uptake in brain was again high but then declined more rapidly than in the baseline scan to a common low level. [{sup 11}C]SP203 was unstable in monkey blood in vitro and in vivo, and gave predominantly less lipophilic radiometabolites

  4. Investigation of the /sup 203/ /sup 205/Tl level schemes after (n,n'gamma) reactions at 2. 75 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Wohlfarth, H.; Kretz, R.; Backe, H.; Hegewisch, S.; Vonach, H.

    1980-06-01

    Some 259 gamma-lines have been observed with Ge(Li) detectors from (/sup 203/ /sup 205/)Tl(n,n'gamma) reactions with 2.75 MeV neutrons using (/sup nat/)Tl and enriched (/sup 203/)Tl samples. The different gamma lines could be attributed unambiguously to the (/sup 203/)Tl and (/sup 205/)Tl isotopes. It was possible to assign only 60 and 54 transitions to the known level schemes of (/sup 203/)Tl and (/sup 205/)Tl, respectively. From these facts it can be concluded that the low spin members in (/sup 203/ /sup 205/) Tl between 1.5 and 2.7 MeV are only partially known. The decay of a 5/2/sup -/ level at 2623.1 keV in (205)Tl was identified and the corresponding transition energies have been measured. With these results isomer shifts of general gamma lines corresponding to the decay of the same 5/2/sup -/ level in muonic (/sup 205/)Tl were determined.

  5. Epidermal anti-Inflammatory properties of 5,11,14 20:3: Effects on mouse ear edema, PGE2 levels in cultured keratinocytes, and PPAR activation

    Directory of Open Access Journals (Sweden)

    Baur Markus

    2002-12-01

    Full Text Available Abstract Background 5,11,14 20:3 is similar to 20:4n-6 but lacks the internal Δ8 double bond essential for prostaglandin and eicosanoid synthesis. When previously fed to laboratory animals as a gymnosperm seed oil component it has shown anti-inflammatory properties. Results Herein, topically applied Podocarpus nagi methyl esters (containing 26% 5,11,14 20:3 were incorporated into mouse ear phospholipids, reduced 20:4n-6, and reduced 20:4n-6- and TPA-induced mouse ear edema. Purified 5,11,14 20:3 was taken up by cultured human skin keratinocytes, reduced 20:4n-6, and reduced PGE2 levels dramatically. Purified 5,11,14 20:3 did not affect PPARα, PPARγ, or PPARδ transactivation. Conclusions Topical application of 5,11,14 20:3 to skin surfaces can thus reduce inflammatory processes, most likely by displacing 20:4n-6 from phospholipid pools and reducing downstream inflammatory products derived from 20:4n-6 such as PGE2 and leukotrienes. It could have potential use in treating clinical skin disorders resulting from overproduction of 20:4n-6-derived eicosanoid products.

  6. A comparison of neuroprotective efficacy of newly developed oximes (K203, K206) and commonly used oximes (obidoxime, HI-6) in tabun-poisoned rats.

    Science.gov (United States)

    Kassa, Jiri; Karasova, Jana; Vasina, Libor; Bajgar, Jiri; Kuca, Kamil; Musilek, Kamil

    2009-01-01

    The neuroprotective effects of newly developed oximes (K203, K206) and commonly used oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with tabun at a sublethal dose (180 microg/kg i.m.; 80% LD(50)) were studied. The tabun-induced neurotoxicity was monitored by using a functional observational battery and an automatic measurement of motor activity. The neurotoxicity of tabun was monitored at 24 hours and 7 days following tabun challenge. The results indicate that K203 and obidoxime in combination with atropine allow all tabun-poisoned rats to survive within 7 days following tabun challenge, while 2 nontreated tabun-poisoned rats and 1 tabun-poisoned rat treated with K206 or HI-6 in combination with atropine died within 7 days. Only one of the newly developed oximes (K203) combined with atropine seems to be effective for a decrease in tabun-induced neurotoxicity within 24 hours after tabun sublethal poisoning, although it is not able to eliminate tabun-induced neurotoxicity completely. On the other hand, the neuroprotective efficacy of commonly used oximes (obidoxime and HI-6), as well as one of the new synthesized oximes (K206), is significantly lower in comparison with K203, according to the number of eliminated tabun-induced neurotoxic signs at 24 hours after tabun challenge. Due to its neuroprotective effects, K203 appears to be a suitable oxime for the antidotal treatment of acute tabun poisonings.

  7. Identification of the impact of crime on physical activity depends upon neighbourhood scale: multilevel evidence from 203,883 Australians.

    Science.gov (United States)

    Astell-Burt, Thomas; Feng, Xiaoqi; Kolt, Gregory S

    2015-01-01

    Equivocal findings on crime as a deterrent for physical activity may be due to effects of geographic scale on exposure measurement. To investigate this hypothesis, physical activity was measured in 203,883 Australians and linked to standardised crime counts within small ('Census Collection Districts'; approx. 330 residents) and larger areas ('Statistical Local Areas'; approx. 32,000 residents). A median rate ratio of 2.26 indicated substantive geographic variation in moderate-to-vigorous physical activity (MVPA). Adjusting for confounders, multilevel negative binomial regression reported lower MVPA with more crime consistently in small, but not in larger areas. Reducing small pockets of local crime may encourage more physically active lifestyles.

  8. miR-203 protects microglia mediated brain injury by regulating inflammatory responses via feedback to MyD88 in ischemia.

    Science.gov (United States)

    Yang, Zhao; Zhong, Lina; Zhong, Shanchuan; Xian, Ronghua; Yuan, Bangqing

    2015-06-01

    Much evidence demonstrates that microglia mediated inflammatory responses play an important role in brain injury in ischemia. miRNA is the important factor in regulation of inflammation. However, the effect of miRNA in microglia mediated inflammatory responses has not been well studied. In the study, we demonstrate that miR-203 negatively regulates ischemia induced microglia activation by targeting MyD88, an important adapter protein involved in most Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) pathways. Through negative feedback, enforced expression of miR-203 or MyD88 siRNA silencing inhibits downstream NF-κβ signaling and microglia activation, thereby alleviating neuronal injury. These findings reveal that miR-203 represents a novel target regulating neuroinflammation and brain injury, thus offering a new therapeutical strategy for cerebral hypoxic diseases.

  9. Conventional superconductivity at 203 kelvin at high pressures in the sulfur hydride system.

    Science.gov (United States)

    Drozdov, A P; Eremets, M I; Troyan, I A; Ksenofontov, V; Shylin, S I

    2015-09-03

    A superconductor is a material that can conduct electricity without resistance below a superconducting transition temperature, Tc. The highest Tc that has been achieved to date is in the copper oxide system: 133 kelvin at ambient pressure and 164 kelvin at high pressures. As the nature of superconductivity in these materials is still not fully understood (they are not conventional superconductors), the prospects for achieving still higher transition temperatures by this route are not clear. In contrast, the Bardeen-Cooper-Schrieffer theory of conventional superconductivity gives a guide for achieving high Tc with no theoretical upper bound--all that is needed is a favourable combination of high-frequency phonons, strong electron-phonon coupling, and a high density of states. These conditions can in principle be fulfilled for metallic hydrogen and covalent compounds dominated by hydrogen, as hydrogen atoms provide the necessary high-frequency phonon modes as well as the strong electron-phonon coupling. Numerous calculations support this idea and have predicted transition temperatures in the range 50-235 kelvin for many hydrides, but only a moderate Tc of 17 kelvin has been observed experimentally. Here we investigate sulfur hydride, where a Tc of 80 kelvin has been predicted. We find that this system transforms to a metal at a pressure of approximately 90 gigapascals. On cooling, we see signatures of superconductivity: a sharp drop of the resistivity to zero and a decrease of the transition temperature with magnetic field, with magnetic susceptibility measurements confirming a Tc of 203 kelvin. Moreover, a pronounced isotope shift of Tc in sulfur deuteride is suggestive of an electron-phonon mechanism of superconductivity that is consistent with the Bardeen-Cooper-Schrieffer scenario. We argue that the phase responsible for high-Tc superconductivity in this system is likely to be H3S, formed from H2S by decomposition under pressure. These findings raise hope for the

  10. Role of the cysteine residues in Arabidopsis thaliana cyclophilin CYP20-3 in peptidyl-prolyl cis-trans isomerase and redox-related functions.

    Science.gov (United States)

    Laxa, Miriam; König, Janine; Dietz, Karl-Josef; Kandlbinder, Andrea

    2007-01-01

    Cyps (cyclophilins) are ubiquitous proteins of the immunophilin superfamily with proposed functions in protein folding, protein degradation, stress response and signal transduction. Conserved cysteine residues further suggest a role in redox regulation. In order to get insight into the conformational change mechanism and functional properties of the chloroplast-located CYP20-3, site-directed mutagenized cysteine-->serine variants were generated and analysed for enzymatic and conformational properties under reducing and oxidizing conditions. Compared with the wild-type form, elimination of three out of the four cysteine residues decreased the catalytic efficiency of PPI (peptidyl-prolyl cis-trans isomerase) activity of the reduced CYP20-3, indicating a regulatory role of dithiol-disulfide transitions in protein function. Oxidation was accompanied by conformational changes with a predominant role in the structural rearrangement of the disulfide bridge formed between Cys(54) and Cys(171). The rather negative E(m) (midpoint redox potential) of -319 mV places CYP20-3 into the redox hierarchy of the chloroplast, suggesting the activation of CYP20-3 in the light under conditions of limited acceptor availability for photosynthesis as realized under environmental stress. Chloroplast Prx (peroxiredoxins) were identified as interacting partners of CYP20-3 in a DNA-protection assay. A catalytic role in the reduction of 2-Cys PrxA and 2-Cys PrxB was assigned to Cys(129) and Cys(171). In addition, it was shown that the isomerization and disulfide-reduction activities are two independent functions of CYP20-3 that both are regulated by the redox state of its active centre.

  11. 5 CFR 843.203 - Eligibility for a one-time payment upon death of an employee, separated employee, or retiree if...

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Eligibility for a one-time payment upon... Payments § 843.203 Eligibility for a one-time payment upon death of an employee, separated employee, or..., the unexpended balance is payable, except as provided in section 3716 of title 31, United States...

  12. 20 CFR 661.203 - What is meant by the terms “optimum policy making authority” and “expertise relating to [a...

    Science.gov (United States)

    2010-04-01

    ... Provisions § 661.203 What is meant by the terms “optimum policy making authority” and “expertise relating to... entity to a chosen course of action. (b) A representative with “expertise relating to program, service or... expertise relating to the One-stop partner program....

  13. 16 CFR 20.3 - Misrepresentation of the terms “rebuilt,” “factory rebuilt,” “remanufactured,” etc.

    Science.gov (United States)

    2010-01-01

    ... INDUSTRY § 20.3 Misrepresentation of the terms “rebuilt,” “factory rebuilt,” “remanufactured,” etc. (a) It... deceptive to represent an industry product as “Factory Rebuilt” unless the product was rebuilt as described in paragraph (a) of this section at a factory generally engaged in the rebuilding of such...

  14. A comparison of neuroprotective efficacy of the oxime K203 and its fluorinated analogue (KR-22836) with obidoxime in Tabun-poisoned rats.

    Science.gov (United States)

    Kassa, Jiri; Karasova, Jana Zdarova; Tesarova, Sandra; Musilek, Kamil; Kuca, Kamil; Jung, Young-Sik

    2010-11-01

    The ability of the newly developed bispyridinium compound K203 and its fluorinated analogue KR-22836 to reduce tabun-induced acute neurotoxic signs and symptoms was compared with the currently available reactivator of acetylcholinesterase-obidoxime. Tabun-induced neurotoxicity and the neuroprotective effects of all tested oximes in combination with atropine in rats poisoned with tabun at a sublethal dose (200 μg/kg intramuscularly (i.m.); 80% of LD(50) value) were monitored by a functional observational battery at 24 hr after tabun challenge. The results indicate that all tested oximes combined with atropine were able to survive tabun-poisoned rats 24 hr after tabun challenge while one non-treated tabun-poisoned rat died within 24 hr after tabun poisoning. All tested oximes combined with atropine were able to decrease tabun-induced neurotoxicity in the case of sublethal poisoning but they did not eliminate all tabun-induced acute neurotoxic signs and symptoms. While the ability to reduce tabun-induced acute neurotoxicity of obidoxime and K203 was similar, the neuroprotective efficacy of KR-22836 was slightly higher compared to other tested oximes. Thus, the newly developed fluorinated analogue of K203, called KR-22836, is able to slightly increase the neuroprotective effectiveness of antidotal treatment of acute tabun poisonings compared to K203 and currently available obidoxime.

  15. Phytophthora fruit rot-resistant watermelon germplasm lines: USVL489-PFR, USVL782-PFR, USVL203-PFR, and USVL020-PFR

    Science.gov (United States)

    USVL489-PFR, USVL782-PFR, USVL203-PFR, and USVL020-PFR are watermelon (Citrullus lanatus var. lanatus (Thunb.) Matsum. & Nakai) germplasm lines that exhibit high levels of resistance to Phytophthora fruit rot caused by the plant pathogen Phytophthora capsici. Resistance in these germplasm lines is ...

  16. 高频电波刀治疗宫颈疾病203例的临床观察

    Institute of Scientific and Technical Information of China (English)

    李东川; 闫燕; 孙晓星

    2005-01-01

    宫颈疾病是指宫颈区域发生的各种病变,包括炎症,损伤,肿瘤(包括癌前病变),畸形等。目前欧美等国家对此类疾病,尤其是宫颈上皮内瘤样变(CIN)Ⅱ—Ⅲ主要采用高频电波刀(leep electrosurgical excision procedure,LEEP)手术治疗,治疗效果得到广大学者认可。我院自2004年5月起应用LEEP手术对203例各类宫颈疾病进行治疗,短期观察疗效满意,现将治疗结果报告如下。

  17. A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice.

    Science.gov (United States)

    Kassa, Jiri; Karasova, Jana Zdarova; Caisberger, Filip; Musilek, Kamil; Kuca, Kamil; Jung, Young-Sik

    2010-08-01

    The potency of newly developed bispyridinium compound K203 and its fluorinated analog KR-22836 in reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods. Studies determining the percentage of reactivation of tabun-inhibited blood and tissue acetylcholinesterase in rats showed that the reactivating efficacy of K203 is higher than the reactivating efficacy of its fluorinated analog KR-22836 as well as currently available oximes studied. The therapeutic efficacy of the oxime K203 and its fluorinated analog corresponds to their potency to reactivate tabun-inhibited acetylcholinesterase. According to the results, the oxime K203 is more suitable than KR-22836 for the replacement of commonly used oximes for the antidotal treatment of acute tabun poisoning due to its relatively high potency to counteract the acute toxicity of tabun.

  18. Oceanographic profile data collected aboard NAVIGATION RESPONSE TEAM 2 as part of project OPR-G443-NRT2-03 from 2003-05-28 to 2004-07-19 (NCEI Accession 0130636)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0130636 includes physical and profile data collected aboard the NAVIGATION RESPONSE TEAM 2 during project OPR-G443-NRT2-03 from 2003-05-28 to...

  19. Study of the effects of applying Federal Motor Vehicle Safety Standards 203 and 204 to light trucks and vans. Modification No. 3 (final)

    Energy Technology Data Exchange (ETDEWEB)

    McLean, R.F.

    1979-05-31

    From a careful inspection of trucks, their possible compliance or non-compliance with the requirements of FMVSS 203 and 204 was determined. Where non-compliance was indicated, design studies were made to bring the trucks into compilance. The added weight of the new designs was estimated. Using established cost estimating procedures, the incremental costs of the new design features were estimated. The manufacturing, wholesale, dealer markup, and total consumer costs were estimated. The average service life of the light trucks was used to establish a lifetime fuel cost based on the effects of the weight increases. The industry's leadtime requirements were discussed. Based on 1978 production volumes, the average cost per truck of complying with FMVSS 203 and 204 would be $11.35 per truck.

  20. Influence of nutrient factors on the growth of Lactoccus latis subsp. Lactis DL-203 and its biosynthesis of Nisin%营养因素对乳酸乳球菌DL-203生长及其Nisin生物合成的影响

    Institute of Scientific and Technical Information of China (English)

    焦中高; 陈海昌; 刘茵

    2003-01-01

    对Nisin高产茵株乳酸乳球菌DL-203的营养要求及其对Nisin生物合成的影响进行了研究.结果表明,乳链茵肽的生物合成与DL-203的生长呈极显著正相关,乳酸乳球菌DL-203生长和合成Nisin的最佳碳源和氮源分别为蔗糖和大豆蛋白胨,其适宜浓度均为15~20g/L.磷酸盐对乳酸乳球菌DL-203生长及其Nisin生物合成具有极大的促进作用,其中以Na2HPO4效果最好,其浓度在224mmol/L以下时时茵体生长和Nisin生物合成具有较大的促进作用.

  1. Application of dual-axis accelerometer ADXL203 in perceptual foot system of humanoid robot%ADXL203型双轴加速计在机器人足部感知系统中的应用

    Institute of Scientific and Technical Information of China (English)

    申海义; 吴宝元; 任阳; 申飞; 吴仲城

    2012-01-01

    In complex environments, ground reaction force can not meet the demand of walking stably for humanoid robot, then angle information of foot is more important in this application. The feet dip angle can reflect the sloping ground state, it is an important basis of the humanoid robot stability control.The high-speed real-time collection and processing of angle information is realized by using ADXL2O3 dual axle acceleration sensor and DSP (TMS3202811), and through the experiment proof that the tilt sensors in the robot foot perception system is feasible.%仿人机器人要实现在复杂环境下稳定行走,仅仅依靠地面反力信息远不能满足应用要求,此时足部的倾角信息显得更为重要.脚面倾角可以反映地面倾斜状态,是仿人机器人稳定控制的一个重要依据.利用ADXL203双轴加速度传感器与DSP (TMS3202811)实现对倾角信息的实时高速采集与处理,并通过实验证明了倾角传感器在机器人足部感知系统中是可行的.

  2. Role of the cysteinyl residues in Arabidopsis thaliana cyclophilin CYP20-3 in peptidyl-prolyl cis-trans isomerase and redox-related functions

    OpenAIRE

    Laxa, Miriam; König, Janine; Dietz, Karl-Josef; Kandlbinder, Andrea

    2006-01-01

    Abstract Cyclophilins (Cyps) are ubiquitous proteins of the immunophilin superfamily with proposed functions in protein folding, protein degradation, stress response and signal transduction. Conserved Cys-residues further suggest a role in redox regulation. In order to get insight into the conformational change mechanism and functional properties of the chloroplast located CYP20-3, site-directed mutagenised Cys->Ser-variants were generated and analyzed for enzymatic and conformatio...

  3. Measurement of hyperfine structure and isotope shift within the 7s1/2-7p1/2 transition in 203-Tl and 205-Tl

    CERN Document Server

    Ranjit, G; Vukasin, G D; Majumder, P K

    2013-01-01

    A two-step, two-color laser spectroscopy technique has been used to determine of the hyperfine splitting (HFS) of the 7p1/2 excited state in 203-Tl and 205-Tl, as well as the isotope shift within the 7s1/2 - 7p1/2 1301 nm transition. We find the hyperfine splittings in 203-Tl and 205-Tl to be 2152.2(7) MHz and 2173.3(8) MHz respectively. The 203-Tl - 205-Tl transition isotope shift is found to be 534.4(9) MHz. The HFS values each disagree by roughly 20 MHz from previously published values which quoted precision comparable to ours. In order to ensure accurate frequency-axis calibration in this new measurement, we employed both a Fabry-Perot cavity, as well as radio-frequency modulation to create sidebands in the absorption spectrum at well-defined frequency separation. In our experiment, one laser was locked to the ground-state 6p1/2 - 7s1/2 378 nm transition, while the second, spatially overlapping laser was scanned across the 7s1/2 (F=1) - 7p1/2 (F=0,1) hyperfine transitions.

  4. IER 203 CED-2 Report: LLNL Final Design for BERP Ball With a Composite Reflector of Thin Polyethylene Backed by Nickel

    Energy Technology Data Exchange (ETDEWEB)

    Percher, C. M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Heinrichs, D. P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kim, S. K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-07-18

    This report documents the results of final design (CED-2) for IER 203, BERP Ball Composite Reflection, and focuses on critical configurations with a 4.5 kg α-phase plutonium sphere reflected by a combination of thin high-density polyethylene (HDPE) backed by a thick nickel reflector. The Lawrence Livermore National Laboratory’s (LLNL’s) Nuclear Criticality Safety Division, in support of fissile material operations, calculated surprisingly reactive configurations when a fissile core was surrounded by a thin, moderating reflector backed by a thick metal reflector. These composite reflector configurations were much more reactive than either of the single reflector materials separately. The calculated findings have resulted in a stricter-than-anticipated criticality control set, impacting programmatic work. IER 203 was requested in response to these seemingly anomalous calculations to see if the composite reflection effect could be shown experimentally. This report focuses on the Beryllium Reflected Plutonium (BERP) ball as a fissile material core reflected by polyethylene and nickel. A total of four critical configurations were designed as part of CED-2. Fabrication costs are estimated to be $98,500, largely due to the cost of the large nickel reflectors. The IER 203 experiments could reasonably be expected to begin in early FY2017,

  5. IER 203 CED-2 Report: LLNL Final Design for BERP Ball With a Composite Reflector of Thin Polyethylene Backed by Nickel

    Energy Technology Data Exchange (ETDEWEB)

    Percher, C. M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Heinrichs, D. P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kim, S. K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-07-18

    This report documents the results of final design (CED-2) for IER 203, BERP Ball Composite Reflection, and focuses on critical configurations with a 4.5 kg α-phase plutonium sphere reflected by a combination of thin high-density polyethylene (HDPE) backed by a thick nickel reflector. The Lawrence Livermore National Laboratory’s (LLNL’s) Nuclear Criticality Safety Division, in support of fissile material operations, calculated surprisingly reactive configurations when a fissile core was surrounded by a thin, moderating reflector backed by a thick metal reflector. These composite reflector configurations were much more reactive than either of the single reflector materials separately. The calculated findings have resulted in a stricter-than-anticipated criticality control set, impacting programmatic work. IER 203 was requested in response to these seemingly anomalous calculations to see if the composite reflection effect could be shown experimentally. This report focuses on the Beryllium Reflected Plutonium (BERP) ball as a fissile material core reflected by polyethylene and nickel. A total of four critical configurations were designed as part of CED-2. Fabrication costs are estimated to be $98,500, largely due to the cost of the large nickel reflectors. The IER 203 experiments could reasonably be expected to begin in early FY2017.

  6. Acute avulsion fractures of the pelvis in adolescent competitive athletes: prevalence, location and sports distribution of 203 cases collected

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, F.; Dragoni, S. [Sports Science Inst., Rome (Italy)

    2001-03-01

    Objective. To describe the prevalence, location and sports distribution of pelvic avulsion fractures in adolescent competitive athletes. Design and patients. One thousand two hundred and thirty-eight radiographs of the pelvis taken for focal traumatic symptoms in athletes with an age range of 11-35 years over a period of 22 years were reviewed. Results. One hundred and ninety-eight adolescent athletes were affected by 203 avulsion fractures of the pelvic apophyses (five cases presented multiple locations). The localisation was the ischial tuberosity (IT) in 109 cases, anterior inferior iliac spine (AIIS) in 45 cases, anterior superior iliac spine (ASIS) in 39 cases, superior corner of pubic symphysis (SCPS) in 7 cases and iliac crest (IC) in 3 cases. Soccer (74 cases) and gymnastics (55 cases) were the sports with the highest number of avulsion fractures documented. Conclusions. Apophyseal avulsion fractures of the pelvis in adolescent competitive athletes are most common in soccer and gymnastics. The lesions are usually the consequence of sudden and forceful muscle-tendon contractions during sport activities. Plain radiographs, are determinant for the diagnosis. (orig.)

  7. Patterns and processes in crop domestication: an historical review and quantitative analysis of 203 global food crops.

    Science.gov (United States)

    Meyer, Rachel S; DuVal, Ashley E; Jensen, Helen R

    2012-10-01

    Domesticated food crops are derived from a phylogenetically diverse assemblage of wild ancestors through artificial selection for different traits. Our understanding of domestication, however, is based upon a subset of well-studied 'model' crops, many of them from the Poaceae family. Here, we investigate domestication traits and theories using a broader range of crops. We reviewed domestication information (e.g. center of domestication, plant traits, wild ancestors, domestication dates, domestication traits, early and current uses) for 203 major and minor food crops. Compiled data were used to test classic and contemporary theories in crop domestication. Many typical features of domestication associated with model crops, including changes in ploidy level, loss of shattering, multiple origins, and domestication outside the native range, are less common within this broader dataset. In addition, there are strong spatial and temporal trends in our dataset. The overall time required to domesticate a species has decreased since the earliest domestication events. The frequencies of some domestication syndrome traits (e.g. nonshattering) have decreased over time, while others (e.g. changes to secondary metabolites) have increased. We discuss the influences of the ecological, evolutionary, cultural and technological factors that make domestication a dynamic and ongoing process.

  8. Purification and Characterization of a New Thermostable κ-Carrageenase from the Marine Bacterium Pseudoalteromonas sp.QY203

    Institute of Scientific and Technical Information of China (English)

    LI Shangyong; JIA Panpan; WANG Linna; YU Wengong; HAN Feng

    2013-01-01

    A new extracellular κ-carrageenase,namely CgkP,34.0 kDa in molecular weight,was purified from Pseudoalteromonas sp.QY203.CgkP showed relatively high activity at acidities ranging from pH6.0 to pH9.0 and temperatures ranging from 30℃ to 50℃ with the highest activity at 45℃ and pH7.2.Sodium chloride increased its activity markedly,and KC1 increased its activity slightly.The divalent and trivalent metal ions including Cu2+,Ni2+,Zn2+,Mn2+,A13+ and Fe3+ significantly inhibited its activity,while Mg2+ did not.CgkP remained 70% of original activity after being incubated at 40℃ for 48 h,and remained 80% of the activity after being incubated at 45 ℃ for 1 h.It exhibited endo-κ-carrageenase activity,mainly depolymerizing the κ-carrageenan into disaccharide and tetrasaccharide.CgkP was more thermostable than most of previously reported κ-carrageenases with a potential of being used in industry.

  9. Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial–mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Dongjing [Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha 410008 (China); Wu, Jilin, E-mail: 6296082@qq.com [Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha 410008 (China); Liu, Meizhou [Department of Medical Service, Shenzhen Second People' s Hospital, Shenzhen, Guangdong 518035 (China); Yin, Hui [Staff' s Hospital, Central South University, Changsha, Hunan 410078 (China); He, Jiantai [Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha 410008 (China); Zhang, Bo, E-mail: zhangbo8095@126.com [Department of Ultrasonography, Xiangya Hospital, Central South University, Changsha, Hunan 410008 (China)

    2015-09-04

    Hepatitis C virus (HCV) Core protein has been demonstrated to induce epithelial–mesenchymal transition (EMT) and is associated with cancer progression of hepatocellular carcinoma (HCC). However, how the Core protein regulates EMT is still unclear. In this study, HCV Core protein was overexpressed by an adenovirus. The protein levels of EMT markers were measured by Western blot. The xenograft animal model was established by inoculation of HepG2 cells. Results showed that ectopic expression of HCV core protein induced EMT in L02 hepatocytes and HepG2 tumor cells by upregulating vimentin, Sanl1, and Snal2 expression and downregulating E-cadherin expression. Moreover, Core protein downregulated miR-30c and miR-203a levels in L02 and HepG2 cells, but artificial expression of miR-30c and miR-203a reversed Core protein-induced EMT. Further analysis showed that ectopic expression of HCV core protein stimulated cell proliferation, inhibited apoptosis, and increased cell migration, whereas artificial expression of miR-30c and miR-203a significantly reversed the role of Core protein in these cell functions in L02 and HepG2 cells. In the HepG2 xenograft tumor models, artificial expression of miR-30c and miR-203a inhibited EMT and tumor growth. Moreover, L02 cells overexpressing Core protein can form tumors in nude mice. In HCC patients, HCV infection significantly shortened patients' survival time, and loss of miR-30c and miR-203 expression correlated with poor survival. In conclusion, HCV core protein downregulates miR-30c and miR-203a expression, which results in activation of EMT in normal hepatocytes and HCC tumor cells. The Core protein-activated-EMT is involved in the carcinogenesis and progression of HCC. Loss of miR-30c and miR-203a expression is a marker for the poor prognosis of HCC. - Highlights: • HCV core protein downregulates miR-30c and miR-203a expression. • Downregulation of miR-30c and miR-203a activates EMT. • Activated-EMT is involved in the

  10. Analysis of characteristics of 203 HIV positive commerercial female sex workers in Guamgxi%广西203例HIV抗体阳性暗娼特征分析

    Institute of Scientific and Technical Information of China (English)

    陈怡; 陈昭霞; 沈智勇; 唐帅; 王露; 林玫

    2016-01-01

    目的:分析HIV抗体阳性暗娼的人口、行为学特征及梅毒/丙肝感染、HIV-1新发感染状况,为制定对策提供科学依据。方法2013年4—7月在全区各档次场所采用分层抽样法对暗娼开展监测,对确证HIV抗体阳性的暗娼监测数据进行统计学分析。结果发现HIV阳性暗娼203例,低档场所占82.2%,小学及以下占71.9%,广西户籍占68.0%,性交易坚持使用安全套占49.8%,最近一年HIV检测比例为39.9%,艾滋病知识知晓率为87.7%;梅毒阳性率为30.5%,HIV-1新发感染率为0.1%。结论广西HIV阳性暗娼来源场所档次低、文化程度低、坚持使用安全套比例低、HIV 检测比例低、梅毒合并感染率高,尽管 HIV-1新发感染率平稳,但今后的宣传干预、早检测、早治疗、联防联控等工作仍需进一步加强。%Objective To analyze the demographic characteristics, HIV related behaviors, syphilis/HCV infection and HIV-1 incidence among HIV positive commercial female sex workers(CSWs), and provide scientific basis for strategy making. Methods The HIV sentinel surveillance was carried out in CSWs in Guangxi from all kinds of tiers of sexual transaction places by stratified sampling in April to July of 2013 and the surveillance data of HIV positive CSWs were analyzed. Results The sentinel surveillance detected 203 HIV positive CSWs. Among them, low tier CSWs accounted for 82.3%. The education level in elementary school or below accounted for 71.9%, those with Guangxi residence accounted for 68.0%. The consistent condom use rate in commercial sex activity was 49.8% . The HIV detection rate for them in the recent year was 39.9% , the HIV knowledge awareness rate was 87.7%, syphilis positive rate was 30.5% among them, HIV-1 incidence was 0.1%. Conclusion Most of the HIV positive CSWs in Guangxi are low tier, low education level, low consistent condom use rate in commercial sex activity, and low HIV detection rate. Even

  11. A novel technique for making open-cell AI203-ZrO2 ceramic foam with plant seed template

    Institute of Scientific and Technical Information of China (English)

    Yu Jingyuan; Li Qiang; Tang Ji; Sun Xudong; Li Xiaodong

    2010-01-01

    The aim of the present research is to provide a technique for preparing open-cell AI203-ZrO2 ceramic foams with uniform cell size. This technique used plant seeds to array templates and centrifugal slip casting to obtain cell struts with high packing density. Aqueous Al2O3-ZrO2 slurries with up to 50 vol.% solid contents were prepared and the rheological characteristic of the slurries was investigated. Consolidation was performed at an acceleration of 2,860 g for 60 rain. The effect of the characteristic of plant seeds on the drying behavior of Al2O3- ZrO2 green compact was analyzed. The effects of the solid contents of slurries on segregation phenomena ofAl2O3 and ZrO2 particles and green compact uniformity were investigated. The compressive stress-strain curve and deformation behavior of Al2O3-ZrO2 ceramic foams prepared using plant seed template were analyzed. The results showed segregation phenomenon is negligible for highly stable slurry with 50 vol.% solid loading. The prepared cell struts of Al2O3-ZrO2 foams have high green density (61.9% TD), sintered density (99.1% TD) and homogeneous microstructure. When sintered at 1,550 ℃ for 2 h, the cell size of Al2O3-ZrO2 foam is approximately uniform and the diameter is about 1.1 mm. The porosity and compressive strength of sintered products is 66.2% and 5.86 MPa, respectively.

  12. Cloning and characterization of a new κ-carrageenase gene from marine bacterium Pseudoalteromonas sp. QY203

    Science.gov (United States)

    Xu, Xiaoyan; Li, Shangyong; Yang, Xuemei; Yu, Wengong; Han, Feng

    2015-12-01

    κ-carrageenan oligosaccharides exhibit various biological activities. Enzymatic degradation by κ-carrageenase is safe and controllable. Therefore, κ-carrageenases have captured more and more attentions. In this study, a κ-carrageenase encoding gene, cgkX, was cloned from Pseudoalteromonas sp. QY203 with degenerate and inverse PCR. It comprised an ORF of 1194 bp in length, encoding a protein with 397 amino acid residues. CgkX is a new member of glycoside hydrolase family 16. The deduced amino acid sequence shared a high similarity with CgkX of Pseudoalteromonas κ-carrageenase; however, the recombinant CgkX showed different biochemical characteristics. The recombinant enzyme was most active at pH 7.0 and 55°C in the presence of 300 mmol L-1 NaCl. It was stable in a broad range of acidity ranging from pH 3.0 to pH 10.0 when temperature was below 40°C. More than 80% of its activity was maintained after being incubated at pH 3.6-10.0 and 4°C for 24 h. CgkX retained more than 90% of activity after being incubated at 40°C for 1 h. EDTA and SDS (1 mmol L-1) did not inhibit its activity. CgkX hydrolyzed κ-carrageenan into disaccharide and tetrasaccharide as an endo-cleaver. All these characteristics demonstrated that CgkX is applicable to both κ-carrageenan oligosaccharide production and κ-carrageenase structure-function research.

  13. The evaluation of the reactivating and therapeutic efficacy of two novel oximes (K361 and K378) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice.

    Science.gov (United States)

    Kassa, Jiri; Sepsova, Vendula; Tumova, Martina; Musilek, Kamil; Horova, Anna

    2014-03-01

    The potency of two newly developed oximes (K361 and K378) to reactivate tabun-inhibited cholinesterase and to reduce acute toxicity of tabun was compared with the oxime K203 and trimedoxime using in vivo methods. The study determining percentage of reactivation of tabun-inhibited diaphragm cholinesterase in poisoned rats showed that the reactivating efficacy of the oxime K378 is slightly lower than the reactivating potency of the oxime K203 and trimedoxime while the ability of the oxime K361 to reactivate tabun-inhibited cholinesterase is markedly lower compared with the oxime K203 and trimedoxime. In the brain, the potency of both newly developed oximes to reactivate tabun-inhibited cholinesterase was negligible. The therapeutic efficacy of both newly developed oximes roughly corresponds to their weak reactivating efficacy. Their potency to reduce acute toxicity of tabun was significantly lower compared with the oxime K203 as well as trimedoxime. In conclusion, the reactivating and therapeutic potency of both newly developed oximes does not prevail the effectiveness of the oxime K203 and trimedoxime and, therefore, they are not suitable for their replacement of commonly used oximes for the treatment of acute tabun poisoning.

  14. The evaluation of the reactivating and therapeutic efficacy of three novel bispyridinium oximes (K454, K456, K458) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice.

    Science.gov (United States)

    Kassa, Jiri; Sepsova, Vendula; Musilek, Kamil; Horova, Anna

    2013-02-01

    The potency of three newly developed bispyridinium compounds (K454, K456, K458) to reactivate tabun-inhibited acetylcholinesterase and reduce tabun-induced lethal toxic effects was compared with the oxime K203 and trimedoxime using in vivo methods. The study determining percentage of reactivation of tabun-inhibited diaphragm and brain acetylcholinesterase in poisoned rats showed that the reactivating efficacy of all newly developed oximes is comparable with K203 but lower than the reactivating potency of trimedoxime in diaphragm. In the brain, their potency to reactivate tabun-inhibited acetylcholinesterase is lower compared with trimedoxime and the oxime K203. All three newly developed oximes were also found to be relatively effective in reducing lethal toxic effects in tabun-poisoned mice. Their therapeutic efficacy is consistent with the therapeutic potency of the oxime K203. On the other hand, their potency to reduce acute toxicity of tabun is significantly lower compared with trimedoxime. In conclusion, the reactivating and therapeutic potency of all three newly developed oximes does not prevail the effectiveness of the oxime K203 and trimedoxime and, therefore, they are not suitable for their replacement of commonly used oximes for the treatment of acute tabun poisoning.

  15. Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents

    Energy Technology Data Exchange (ETDEWEB)

    Tiwari, Prakash; Gupta, Krishna P., E-mail: krishnag522@yahoo.co.in

    2014-07-15

    We investigated the chemopreventive effects of naturally occurring compounds like butyric acid (BA), nicotinamide (NA) and calcium glucarate (CAG) individually or in combination in 7, 12-dimethylbenz [a] anthracene (DMBA) treated mouse skin at 4 and 16 weeks, the time before and after the tumor development. DMBA application did not show any skin tumors at 4 weeks but well defined tumors appeared at 16 weeks. BA, NA or CAG prevented the tumor development significantly but the protection was highly enhanced when all these compounds were given together. In order to see the molecular changes progressing with tumors, we showed the downregulation of tumor suppressor miR-203 at 16 weeks and upregulation of histone deacetylases (HDAC), DNA methyltransferase, promoter methylation of miR-203 at 4 or 16 weeks. Regulators of micro RNA biogenesis such as DICER1 and Ago2 were also deregulated by DMBA. Proto-oncogene c-myc and BMI1 were upregulated and tumor suppressor gene p16 was downregulated by DMBA as a function of time. Effects of BA, NA or CAG were more pronounced after 16 weeks as compared to 4 weeks in preventing the tumor development and altered gene expression. Concomitant administration of BA, NA and CAG tried to prevent these alterations more effectively than that of individual compound possibly by regulating miR-203 status through epigenetic or biogenetic modulations before and after the tumor development. Study provides a rationale for chemoprevention by combination of different compounds targeting miR-203. - Highlights: • DMBA modulates miR-203 and its regulator before and after the onset of tumors. • Suppression of miR-203 and p16 could be the result of gene promoter methylation. • BA, NA or CAG prevents the effects of DMBA. • Combination of BA, NA or CAG is more effective in preventing the DMBA modulations.

  16. An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.

    Science.gov (United States)

    Kassa, Jiri; Karasova, Jana; Musilek, Kamil; Kuca, Kamil

    2008-01-20

    The potency of newly developed monoxime bispyridinium compounds (K156, K203) in reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods. Studies determining percentage of reactivation of tabun-inhibited blood and tissue acetylcholinesterase in poisoned rats showed that the reactivating efficacy of newly developed oxime K203 is comparable with obidoxime and trimedoxime in blood and higher than the reactivating potency of trimedoxime and obidoxime in diaphragm and brain, where the difference in reactivating efficacy of obidoxime, trimedoxime and K203 is significant. On the other hand, the potency of newly developed K156 to reactivate tabun-inhibited acetylcholinesterase is comparable with obidoxime or trimedoxime in diaphragm and brain. It is significantly lower than the reactivating efficacy of trimedoxime and obidoxime in blood. Moreover, both newly developed oximes were found to be relatively efficacious in the reduction of lethal toxic effects in tabun-poisoned mice. Especially, the oxime K203 is able to decrease the acute toxicity of tabun nearly two times. The therapeutic efficacy of K156 and K203 corresponds to their potency to reactivate tabun-inhibited acetylcholinesterase, especially in diaphragm and brain. In contrast to obidoxime and trimedoxime, the oxime HI-6 is not effective in reactivation of tabun-inhibited acetycholinesterase and in reducing tabun lethality. While the oxime K156 does not improve the reactivating and therapeutic effectiveness of currently available obidoxime and trimedoxime, the newly developed oxime K203 is markedly more effective in reactivation of tabun-inhibited acetylcholinesterase in rats, especially in brain, and in reducing lethal toxic effects of tabun in mice and, therefore, it is suitable for the replacement of commonly used oximes for the antidotal treatment of acute tabun

  17. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness

    Science.gov (United States)

    Le, Lily Thao-Nhi; Cazares, Oscar; Mouw, Janna K.; Chatterjee, Sharmila; Macias, Hector; Moran, Angel; Ramos, Jillian; Keely, Patricia J.; Weaver, Valerie M.

    2016-01-01

    Breast tumor progression is accompanied by changes in the surrounding extracellular matrix (ECM) that increase stiffness of the microenvironment. Mammary epithelial cells engage regulatory pathways that permit dynamic responses to mechanical cues from the ECM. Here, we identify a SLIT2/ROBO1 signaling circuit as a key regulatory mechanism by which cells sense and respond to ECM stiffness to preserve tensional homeostasis. We observed that Robo1 ablation in the developing mammary gland compromised actin stress fiber assembly and inhibited cell contractility to perturb tissue morphogenesis, whereas SLIT2 treatment stimulated Rac and increased focal adhesion kinase activity to enhance cell tension by maintaining cell shape and matrix adhesion. Further investigation revealed that a stiff ECM increased Robo1 levels by down-regulating miR-203. Consistently, patients whose tumor expressed a low miR-203/high Robo1 expression pattern exhibited a better overall survival prognosis. These studies show that cells subjected to stiffened environments up-regulate Robo1 as a protective mechanism that maintains cell shape and facilitates ECM adherence. PMID:26975850

  18. Acetylcholinesterase Reactivators (HI-6, Obidoxime, Trimedoxime, K027, K075, K127, K203, K282: Structural Evaluation of Human Serum Albumin Binding and Absorption Kinetics

    Directory of Open Access Journals (Sweden)

    Filip Zemek

    2013-08-01

    Full Text Available Acetylcholinesterase (AChE reactivators (oximes are compounds predominantly targeting the active site of the enzyme. Toxic effects of organophosphates nerve agents (OPNAs are primarily related to their covalent binding to AChE and butyrylcholinesterase (BChE, critical detoxification enzymes in the blood and in the central nervous system (CNS. After exposure to OPNAs, accumulation of acetylcholine (ACh overstimulates receptors and blocks neuromuscular junction transmission resulting in CNS toxicity. Current efforts at treatments for OPNA exposure are focused on non-quaternary reactivators, monoisonitrosoacetone oximes (MINA, and diacylmonoxime reactivators (DAM. However, so far only quaternary oximes have been approved for use in cases of OPNA intoxication. Five acetylcholinesterase reactivator candidates (K027, K075, K127, K203, K282 are presented here, together with pharmacokinetic data (plasma concentration, human serum albumin binding potency. Pharmacokinetic curves based on intramuscular application of the tested compounds are given, with binding information and an evaluation of structural relationships. Human Serum Albumin (HSA binding studies have not yet been performed on any acetylcholinesterase reactivators, and correlations between structure, concentration curves and binding are vital for further development. HSA bindings of the tested compounds were 1% (HI-6, 7% (obidoxime, 6% (trimedoxime, and 5%, 10%, 4%, 15%, and 12% for K027, K075, K127, K203, and K282, respectively.

  19. A comparison of the neuroprotective efficacy of individual oxime (HI-6) and combinations of oximes (HI-6+trimedoxime, HI-6+K203) in soman-poisoned rats.

    Science.gov (United States)

    Kassa, Jiri; Karasova, Jana Zdarova; Tesarova, Sandra

    2011-07-01

    The ability of two combinations of oximes (HI-6+trimedoxime, HI-6+K203) to reduce soman-induced acute neurotoxic signs and symptoms was compared with the neuroprotective efficacy of the oxime HI-6 alone, using a functional observational battery. Soman-induced neurotoxicity and the neuroprotective effects of HI-6 alone and HI-6 combined with trimedoxime or K203 in rats poisoned with soman at a sublethal dose (90 μg/kg intramuscularly, i.m.; 80% of LD₅₀ value) were monitored by the functional observational battery at 24 hours following soman administration. The results indicate that both tested oxime mixtures combined with atropine were able to allow soman-poisoned rats to survive 24 hours following soman challenge, while 4 nontreated soman-poisoned rats and 1 soman-poisoned rat treated with oxime HI-6 alone combined with atropine died within 24 hours following soman poisoning. While the oxime HI-6 alone combined with atropine treatment was able to eliminate a few soman-induced neurotoxic signs and symptoms, both oxime mixtures showed higher neuroprotective efficacy in soman-poisoned rats. Especially, the combination of HI-6 with trimedoxime was able to eliminate most soman-induced neurotoxic signs and symptoms and markedly reduce acute neurotoxicity of soman in rats. Thus, both tested mixtures of oximes combined with atropine were able to increase the neuroprotective effectiveness of antidotal treatment of acute soman poisonings, compared to the individual oxime.

  20. The Roles of miR-26, miR-29, and miR-203 in the Silencing of the Epigenetic Machinery during Melanocyte Transformation.

    Science.gov (United States)

    Gasque Schoof, Cláudia Regina; Izzotti, Alberto; Jasiulionis, Miriam Galvonas; Vasques, Luciana Dos Reis

    2015-01-01

    The epigenetic marks located throughout the genome exhibit great variation between normal and transformed cancer cells. While normal cells contain hypomethylated CpG islands near gene promoters and hypermethylated repetitive DNA, the opposite pattern is observed in cancer cells. Recently, it has been reported that alteration in the microenvironment of melanocyte cells, such as substrate adhesion blockade, results in the selection of anoikis-resistant cells, which have tumorigenic characteristics. Melanoma cells obtained through this model show an altered epigenetic pattern, which represents one of the first events during the melanocytes malignant transformation. Because microRNAs are involved in controlling components of the epigenetic machinery, the aim of this work was to evaluate the potential association between the expression of miR-203, miR-26, and miR-29 family members and the genes Dnmt3a, Dnmt3b, Mecp2, and Ezh2 during cells transformation. Our results show that microRNAs and their validated or predicted targets are inversely expressed, indicating that these molecules are involved in epigenetic reprogramming. We also show that miR-203 downregulates Dnmt3b in mouse melanocyte cells. In addition, treatment with 5-aza-CdR promotes the expression of miR-26 and miR-29 in a nonmetastatic melanoma cell line. Considering the occurrence of CpG islands near the miR-26 and miR-29 promoters, these data suggest that they might be epigenetically regulated in cancer.

  1. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness.

    Science.gov (United States)

    Le, Lily Thao-Nhi; Cazares, Oscar; Mouw, Janna K; Chatterjee, Sharmila; Macias, Hector; Moran, Angel; Ramos, Jillian; Keely, Patricia J; Weaver, Valerie M; Hinck, Lindsay

    2016-03-14

    Breast tumor progression is accompanied by changes in the surrounding extracellular matrix (ECM) that increase stiffness of the microenvironment. Mammary epithelial cells engage regulatory pathways that permit dynamic responses to mechanical cues from the ECM. Here, we identify a SLIT2/ROBO1 signaling circuit as a key regulatory mechanism by which cells sense and respond to ECM stiffness to preserve tensional homeostasis. We observed that Robo1 ablation in the developing mammary gland compromised actin stress fiber assembly and inhibited cell contractility to perturb tissue morphogenesis, whereas SLIT2 treatment stimulated Rac and increased focal adhesion kinase activity to enhance cell tension by maintaining cell shape and matrix adhesion. Further investigation revealed that a stiff ECM increased Robo1 levels by down-regulating miR-203. Consistently, patients whose tumor expressed a low miR-203/high Robo1 expression pattern exhibited a better overall survival prognosis. These studies show that cells subjected to stiffened environments up-regulate Robo1 as a protective mechanism that maintains cell shape and facilitates ECM adherence.

  2. Efficacy and complications of ultrasound-guided percutaneous renal biopsy using 18 G automatic biopsy gun in diffuse renal disease: Analysis of 203 cases

    Energy Technology Data Exchange (ETDEWEB)

    Gwon, Dong Il; Lee, Kang Hoon; Song, Kyung Sup; An, Suk Joo; Son, Sang Bum; Kim, Hyeon Suk [The Catholic University of Korea, St. Paul' s Hospital, Seoul (Korea, Republic of); Kim, Jee Young; Kim, Won Young; Park, Young Ha [The Catholic University of Korea, St. Vincent' s Hospital, Suwon (Korea, Republic of)

    2000-12-15

    To evaluate the efficacy and complications of ultrasound-guided percutaneous renal biopsy using 18G automatic biopsy gun in patients with diffuse renal disease. 203 ultrasound-guided renal biopsies using 18G automatic biopsy gun were performed in 197 patients for the diagnosis of diffuse renal disease. The success and complication rates were retrospectively evaluated by analysis of pathologic and clinical records and post-procedure ultrasonograms of the patients. Out of 203 renal biopsies, adequate tissues for pathologic diagnosis were obtained in 184 (90.6%) biopsies. The mean number of needle passes was 2.08, and the mean number of retrieved glomeruli was 7.71 {+-} 4.23. Minor complications occurred in seven biopsies (3.45%) including asymptomatic macroscopic hematuria in five (2.45%) and small subcapsular hematomas in two (1%). No patients required transfusion or surgery because of biopsy-related complication. Ultrasound-guided percutaneous renal biopsy using 18G automatic biopsy gun was an effective method for the pathologic diagnosis of diffuse renal disease and safe with low complication rate related to the procedure.

  3. Cosmetology 103, 203, 303.

    Science.gov (United States)

    Manitoba Dept. of Education, Winnipeg.

    As part of the high school vocational industrial program in Manitoba, this course has been designed to provide students with the foundation for a career in cosmetology. The program introduces and provides opportunities for student skill development in the techniques of hairdressing, hair cutting, facial preparation, and skin care. The program,…

  4. BCG对小鼠RAW264.7巨噬细胞miR-203、miR-142-3p、miR-21表达的影响%Effect of BCG on expression of miR-203, miR-142-3p and miR-21 in mouse RAW264.7 macrophages

    Institute of Scientific and Technical Information of China (English)

    张兆波; 魏军; 汤建中; 赵志军; 张一琳; 张瑞芹; 徐广贤

    2013-01-01

    目的:检测卡介苗(Bacillus Calmette-Guerin,BCG)刺激巨噬细胞后miR-203、miR-142-3p、miR-21表达量的变化,为研究microRNA(miRNA)在巨噬细胞抗结核分枝杆菌免疫应答中的调控作用提供依据.方法:利用浓度为1.0 ×107ml-1的BCG刺激培养的小鼠RAW264.7细胞,分别在4、8、12、24小时提取细胞small RNA,并利用相应的茎环反转录引物,反转录成cDNA,同时构建成熟miR-203、miR-142-3p、miR-21的T载体,绘制标准曲线,利用Real-Time PCR检测miR-203、miR-142-3p、miR-21的表达量.结果:BCG作用RAW264.7细胞4、8、12、24小时后,miR-21表达显著性上调(10倍以上,P<0.05),miR-142-3p表达显著性下调(20倍以上,P<0.05),miR-203在4、8、12小时表达下调(3倍以上,P<0.05),24小时后表达上调(2倍以上,P<0.05).结论:BCG刺激RAW264.7巨噬细胞后,miR-203、miR-142-3p、miR-21的表达发生显著性变化,说明这些miRNA可能通过调控免疫相关基因在巨噬细胞抗结核分枝杆菌的免疫应答中发挥着重要的作用.%Objective: To detect the influence of Bacillus Calmette-Guerin (BCG) on the expression of miit-203, miR-142-3p and miR-21 in the macrophages and provide the basis to study the regulation of miRNA in the immune response of macrophages to My-cobacterium tuberculosis. Methods:Small RNA was extracted at different times after stimulated with a concentration of 1.0 × 107 ml"1 of BCG in cultured mouse RAW264. 7 cells. After using stem-loop reverse transcription primers to reverse transcribed into cDNA, the expression of miR-203, miR-142-3p and miR-21 was detected by Real-time PCR. At the same time, building the T vector of mature miR-203, miR-142-3p and miR- 21 to make the standard curve. Results:After RAW264.7 cells was treated by BCG for 4, 8, 12 and 24 h, miR-21 expression was up-regulated significantly (More than 10 times, P < 0. 05). However, miR-142-3 p was significantly down-regulated at the same time( More than 20 times, P <0. 05

  5. A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (k727 and k733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice.

    Science.gov (United States)

    Kassa, Jiri; Sepsova, Vendula; Tumova, Martina; Horova, Anna; Musilek, Kamil

    2015-04-01

    The reactivating and therapeutic efficacy of three original bispyridinium oximes (K727, K733 and K203) and one currently available oxime (trimedoxime) was evaluated in tabun-poisoned rats and mice. The oxime-induced reactivation of tabun-inhibited acetylcholinesterase was measured in diaphragm and brain of tabun-poisoned rats. The results showed that the reactivating efficacy of two recently developed oximes (K727 and K733) does not achieve the level of the reactivation of tabun-inhibited acetylcholinesterase induced by oxime K203 and trimedoxime. While all oximes studied were able to increase the activity of tabun-inhibited acetylcholinesterase in diaphragm, oxime K733 was not able to reactivate tabun-inhibited acetylcholinesterase in the brain. The therapeutic efficacy of all oximes studied roughly corresponds to their reactivating efficacy. While both recently developed oximes were able to reduce acute toxicity of tabun less than 1.5-fold, another original oxime K203 and commonly used trimedoxime reduced the acute toxicity of tabun almost two times. In conclusion, the reactivating and therapeutic potency of both newly developed oximes does not prevail the effectiveness of oxime K203 and trimedoxime, and therefore, they are not suitable for their replacement of commonly used oximes for the antidotal treatment of acute tabun poisoning.

  6. Physiological studies of environmental pollutants. Progress report, September 1, 1975--May 31, 1976. [/sup 210/Po, /sup 203/Pb, /sup 201/Tl, /sup 207/Bi, /sup 65/Zn

    Energy Technology Data Exchange (ETDEWEB)

    Lengemann, F W; Wentworth, R A

    1976-01-01

    In the past year we have looked at the transfer of some members of the actinide decay series into milk of goats. These were /sup 210/Po, /sup 203/Pb, /sup 201/Tl and /sup 207/Bi. All of these appeared in milk after oral ingestion but at levels less than 1 percent per liter. In addition we have looked at the transfer of /sup 65/Zn into milk of goats after oral and I.V. doses; the experiments are incomplete at this time. In controlled temperature studies it was found that 6.6 times as much radioiodine was secreted into milk when goats were at 33/sup 0/ as opposed to 5/sup 0/C. When radioiodine is put into the mammary gland the transfer from milk to body is rapid; more rapid than is the case for /sup 65/Zn. The analysis of these data indicate the need for a model capable of handling expansion of a compartment.

  7. Search for diboson resonances with jets in 20.3 fb$^{-1}$ pp collisions at $\\sqrt{s} =$ 8 TeV with the ATLAS detector

    CERN Document Server

    Picazio, Attilio; The ATLAS collaboration

    2015-01-01

    A search for narrow diboson high mass resonances in a dijet final state is performed in 20.3 fb$^{-1}$ of proton-proton collisions at a center-of-mass energy of $\\sqrt{s} =$ 8 TeV, collected in 2012 by the ATLAS detector at the Large Hadron Collider. The jet mass and jet substructure properties have been used to tag each jet as a boson. Using the invariant mass distribution of the boson tagged dijet system, 95 $\\%$ CL exclusion limits are set on the production cross section times branching ratio to $WW$, $WZ$, or $ZZ$ final states of $W^{\\prime}$ Extended Gauge Model (EGM) bosons and Kaluza-Klein excitations of the graviton in the bulk Randall-Sundrum model, as a function of the resonance mass. The observed mass distributions exhibit an excess of events above 1.8 TeV.

  8. The Roles of miR-26, miR-29, and miR-203 in the Silencing of the Epigenetic Machinery during Melanocyte Transformation

    Directory of Open Access Journals (Sweden)

    Cláudia Regina Gasque Schoof

    2015-01-01

    Full Text Available The epigenetic marks located throughout the genome exhibit great variation between normal and transformed cancer cells. While normal cells contain hypomethylated CpG islands near gene promoters and hypermethylated repetitive DNA, the opposite pattern is observed in cancer cells. Recently, it has been reported that alteration in the microenvironment of melanocyte cells, such as substrate adhesion blockade, results in the selection of anoikis-resistant cells, which have tumorigenic characteristics. Melanoma cells obtained through this model show an altered epigenetic pattern, which represents one of the first events during the melanocytes malignant transformation. Because microRNAs are involved in controlling components of the epigenetic machinery, the aim of this work was to evaluate the potential association between the expression of miR-203, miR-26, and miR-29 family members and the genes Dnmt3a, Dnmt3b, Mecp2, and Ezh2 during cells transformation. Our results show that microRNAs and their validated or predicted targets are inversely expressed, indicating that these molecules are involved in epigenetic reprogramming. We also show that miR-203 downregulates Dnmt3b in mouse melanocyte cells. In addition, treatment with 5-aza-CdR promotes the expression of miR-26 and miR-29 in a nonmetastatic melanoma cell line. Considering the occurrence of CpG islands near the miR-26 and miR-29 promoters, these data suggest that they might be epigenetically regulated in cancer.

  9. NITRATE + NITRITE CONTENT (CONCENTRATION), PHOSPHATE, NITRITE, SILICATE and other profile and discrete sample data collected in the Gulf of Alaska on the ALPHA HELIX and WECOMA cruises HX203, HX205 and others as part of the NEP project from 1998-03-08 to 2004-07-05 (NODC Accession 0115260)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0115260 includes profile, discrete sample and chemical data collected aboard the ALPHA HELIX and WECOMA during cruises HX203, HX205, HX208, HX211,...

  10. SALINITY, WATER TEMPERATURE, FLUORESCENCE, PHOTOSYNTHETIC ACTIVE RADIATION (PAR) and other profile data collected in the Gulf of Alaska on the ALPHA HELIX and WECOMA cruises HX201, HX203 and others as part of the NEP project from 1997-10-10 to 2004-12-09 (NODC Accession 0113922)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0113922 includes profile, biological and physical data collected aboard the ALPHA HELIX and WECOMA during cruises HX201, HX203, HX205, HX208, HX211,...

  11. BIOMASS, SPECIES IDENTIFICATION, TAXONOMIC CODE, SPECIES IDENTIFICATION - LIFE STAGE and species abundance tows data collected in the Gulf of Alaska on the ALPHA HELIX and WECOMA cruises HX201, HX203 and others as part of the NEP project from 1997-10-10 to 2004-10-07 (NODC Accession 0113896)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0113896 includes tows and biological data collected aboard the ALPHA HELIX and WECOMA during cruises HX201, HX203, HX205, HX208, HX211, HX215, HX217,...

  12. A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.

    Science.gov (United States)

    Kassa, Jiri; Karasova, Jana Zdarova; Pavlikova, Ruzena; Musilek, Kamil; Kuca, Kamil; Bajgar, Jiri; Jung, Young-Sik

    2011-03-01

    The potency of bispyridinium acetylcholinesterase reactivator KR-22934 in reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic effects was compared with the oxime K203 and commonly used oximes. Studies determining percentage of reactivation of tabun-inhibited blood and tissue acetylcholinesterase in rats showed that the reactivating efficacy of KR-22934 was slightly higher than the reactivating efficacy of K203 and roughly corresponded to the reactivating efficacy of obidoxime and trimedoxime in blood and diaphragm. On the other hand, the oxime KR-22934 was not able to reactivate tabun-inhibited acetylcholinesterase in the brain. The therapeutic efficacy of all oximes studied approximately corresponded to their reactivating efficacy. Based on the results, one can conclude that the oxime KR-22934 is not suitable for the replacement of commonly used oximes for the antidotal treatment of tabun poisoning in spite of its potency to reactivate tabun-inhibited acetylcholinesterase in the peripheral compartment (blood, diaphragm).

  13. Factors Associated with Advanced Inferior Vena Cava Filter Removals: A Single-Center Retrospective Study of 203 Patients Over 7 Years

    Energy Technology Data Exchange (ETDEWEB)

    Dowell, Joshua D., E-mail: Joshua.Dowell@osumc.edu; Wagner, Daniel, E-mail: Daniel.Wagner@osumc.edu; Elliott, Eric, E-mail: Eric.Elliott@osumc.edu [The Ohio State University Wexner Medical Center, Department of Radiology, Division of Interventional Radiology (United States); Yildiz, Vedat O., E-mail: Vedat.Yildiz@osumc.edu; Pan, Xueliang, E-mail: Jeff.Pan@osumc.edu [The Ohio State University Wexner Medical Center, Center for Biostatistics (United States)

    2016-02-15

    PurposeTo identify factors associated with advanced inferior vena cava filter (IVCF) retrieval to raise awareness on technical considerations, retrieval efficiency, and patient safety.Materials and MethodsA single-center retrospective review was performed of 203 consecutive retrievable IVC filters placed between 2007 and 2014. Attempted retrievals were classified as advanced if the routine “snare and sheath” technique was initially unsuccessful after multiple attempts, or an alternate endovascular maneuver or access site was utilized. Patient and filter characteristics were recorded.Results203 attempted retrievals were reviewed (48.7 % male, 51.2 % female, mean age 52.7 years, mean dwell time 109 days). Advanced retrievals were observed in 20 patients (9.8 %) (15 females, 5 males). Fluoroscopy time (p ≤ 0.01, 34.3 ± 21.1 and 5.3 ± 4.5 min for advanced retrievals and routine retrievals respectively, same below), gender (p = 0.031), and retrieval tilt angle (p ≤ 0.01, 5.7 ± 5.10° vs. 11.9 ± 11.03°) were associated with advanced retrievals. Females were 3.16 times more likely to have an advanced retrieval performed than males with a significantly higher tilt angle in those with advanced retrieval. History of cancer (p = 0.502), dwell time (p = 0.916), retrieval caval diameter (p = 0.053), placement caval diameter (p = 0.365), filter type (p = 0.710), strut perforation (p = 0.506), placement tilt angle (p = 0.311), and age (p = 0.558) were not found significantly associated with advanced retrievals.ConclusionsWomen are at increased risk for advanced filter retrieval secondary to a significant change in filter tilt over time compared to men, independent of filter type or competing demographic or filter risks, likely placing them at increased risk for higher procedural fluoroscopy times.

  14. Clinical utility of multiplex ligation-dependent probe amplification technique in identification of aetiology of unexplained mental retardation: A study in 203 Indian patients

    Directory of Open Access Journals (Sweden)

    Vijay R Boggula

    2014-01-01

    Full Text Available Background & objectives: Developmental delay (DD/mental retardation also described as intellectual disability (ID, is seen in 1-3 per cent of general population. Diagnosis continues to be a challenge at clinical level. With the advancement of new molecular cytogenetic techniques such as cytogenetic microarray (CMA, multiplex ligation-dependent probe amplification (MLPA techniques, many microdeletion/microduplication syndromes with DD/ID are now delineated. MLPA technique can probe 40-50 genomic regions in a single reaction and is being used for evaluation of cases with DD/ID. In this study we evaluated the clinical utility of MLPA techniques with different probe sets to identify the aetiology of unexplained mental retardation in patients with ID/DD. Methods: A total of 203 randomly selected DD/ID cases with/without malformations were studied. MLPA probe sets for subtelomeric regions (P070/P036 and common microdeletions/microduplications (P245-A2 and X-chromosome (P106 were used. Positive cases with MLPA technique were confirmed using either fluorescence in situ hybridization (FISH or follow up confirmatory MLPA probe sets. Results: The overall detection rate was found to be 9.3 per cent (19 out of 203. The detection rates were 6.9 and 7.4 per cent for common microdeletion/microduplication and subtelomeric probe sets, respectively. No abnormality was detected with probe set for X-linked ID. The subtelomeric abnormalities detected included deletions of 1p36.33, 4p, 5p, 9p, 9q, 13q telomeric regions and duplication of 9pter. The deletions/duplications detected in non telomeric regions include regions for Prader Willi/Angelman regions, Williams syndrome, Smith Magenis syndrome and Velocardiofacial syndrome. Interpretation & conclusions: Our results show that the use of P245-A2 and P070/P036-E1 probes gives good diagnostic yield. Though MLPA cannot probe the whole genome like cytogenetic microarray, due to its ease and relative low cost it is an

  15. 雄甾-4-烯-3,17-二酮11α羟化突变株Metarhizium anisopliae M28-203的代谢调控%Metabolic regulation of androst-4-ene-3,17-dione 11α-hydroxylation mutant strain Metarhizium anisopliae M28-203

    Institute of Scientific and Technical Information of China (English)

    叶丽; 周珮; 冯美卿

    2011-01-01

    目的 从营养代谢调控和转化条件控制两个方面入手提高雄甾-4-烯-3,17-二酮(androst-4-ene-3,17-dione,AD)11α羟化突变株Metarhizium anisopliae M28-203转化效率.方法 通过正交试验确定发酵培养基配方,对影响转化的一系列因素如:pH、发酵时间、通气量、底物投料量及溶解性、细胞通透性进行控制,考察以上因素对羟化反应的影响,确定最佳转化条件.结果 该突变株培养基最佳配方为葡萄糖30 g/L、玉米浆20 g/L、蚕蛹粉5 g/L、硫酸铵2.5 g/L、磷酸氢二钾1 g/L、硫酸镁0.5 g/L和硫酸亚铁0.02 g/L.在pH 6.0~6.5、菌龄48~60 h、250 mL摇瓶装液量为30和40 mL、转化时间72 h时能取得最佳转化效果.在底物投料量为2 mg/mL时,采用4%无水乙醇溶解底物或加入0.75 mg/mL Tween 80均有利于羟化反应,在以上优化条件下转化率分别达到62.5%和66.8%.结论 突变株Metarhizium anisopliae M28-203能有效地在AD上引入11α羟基,为工业生产依普利酮及其他甾体药物提供关键中间体.%Objective To improve the transformation efficiency of androst-4-ene-3, 17-dione (AD) llα-hydroxylation mutant strain Metarhizium anisopliae M28-203 through regulations of nutrition metabolism and biotransformation conditions. Methods The optimal fermentation culture was determined by orthogonal test. The effects of pH, fermentation time, air flow, substrate addition method and substrate concentration on hydroxylation were investigated and the optimal transformation condition was constructed. Results The optimal fermentation culture contained glucose 30 g/L, corn steep 20 g/L, silkworm chrysalis powder 5 g/L, (NH4)2SO4 2.5 g/L, K2HPO4 1 g/L, MgSO4 0.5 g/L and FeSO4 0.02 g/L. The optimal transformation condition was pH 6.0 - 6.5, 48 - 60 h mycelium age, 30 and 40 mL medium volume in 250 mL shake flask and 72 hour transformation time. Both 4% ethanol and 0.75 mg/mL Tween 80 were helpful for substrate solubility, and then

  16. /sup 99m/pertechnetate uptake in the transplanted kidney. [/sup 99m/Tc, /sup 133/Xe, /sup 131/I, /sup 203/Hg

    Energy Technology Data Exchange (ETDEWEB)

    Aquino, H.C.; Preston, D.F.; Luke, R.G.

    1971-01-01

    Acute renal failure is a common complication of kidney transplantation. The major causes are acute tubular necrosis (ATN), arterial or venous thrombosis, rejection, ureteral obstruction, and extravasation. Each situation requires a different treatment and demands prompt diagnosis to prevent loss of the graft and patient morbidity or mortality. The clinical problem is further complicated by the possible coincidence of more than one of these pathologies, in particular the development of graft rejection superimposed on ATN in the post-transplant period. The diagnostic studies used in this differential diagnosis may include retrograde ureteral catheterization, renal arteriography, open or closed renal biopsy, isotope studies with /sup 133/xenon, /sup 131/I-hippuran, /sup 203/Hg-chlormerodrin, and more recently /sup 99m/pertechnetate. Only the latter methods with hippuran, chlormerodrin, and pertechnetate avoid direct manipulation of the graft or its artery or ureter with the inherent risks of such procedures. We present results of serial studies of sodium /sup 99m/pertechnetate photoscanning(Tc scan) in 38 renal homografts. In some studies computer determined graphs of renal radioactivity versus time (Tc renogram) were obtained.

  17. 湘西吉首市203各社区老年人生活自理能力状况分析

    Institute of Scientific and Technical Information of China (English)

    薛桂娥; 陈正英; 沙永红

    2010-01-01

    目的 了解少数民族地区老年人生活自理能力状况,促进老年人社区卫生服务工作.方法 采用日常生活能力量表(ADL)对湘西自治州吉首市峒河社区向阳居委会的老年人进行调查.结果 受调查的203名老年人生活自理能力完全丧失率为1.0%,其中躯体生活自理能力(PSMS)和工具性日常生活活动功能(IADL)完全丧失率分别为1.0%和3.4%,PSMS的6项功能中,丧失率最高的是洗澡(6.9%),IADL的8项功能中,丧失率最高的是做饭菜(19.2%).结论 湘西地区老年人生活自理能力丧失状况有区域性特点,在社区卫生服务工作中这应引起重视.

  18. Comparison beta absorbed dose from 203Hg, 166Ho and 177LU isotopes in cortex and medulla in tree part kidney and integrated kidney using Monte Carlo method

    Directory of Open Access Journals (Sweden)

    Mohammad Mirzaei

    2015-04-01

    Full Text Available Background: Large quantities of radiopharmaceuticals prescribed for treatment and diagnosis are excreted through kidney. Therefore, radiation unwanted dose is created in kidney. As a result, exact calculation of prescribed medicine amount is important. In Mird pamphlet, 5 kidneys have considered in ellipsoidal shape that radiopharmaceutical is uniform distributed in them and gamma absorption fraction is calculated and recorded in the tables and the fraction of beta absorption is considered unit. While, kidney has internal organs and radioisotope is not uniform distributed in and beta absorbed fraction is not unit. Material and method: In this research, for the first time kidney is considered integrated shape and for the second time has been considered that it is consisted of three areas, pelvis, medulla and cortex. It is supposed that radiopharmaceutical is distributed in medulla. Then, beta absorbed dose is calculated in medulla and cortex using MCNPX code and is compared with integrated kidney results. Resuts: This research has been showed that beta absorbed dose from 203Hg, 166Ho and 177Lu isotopes in medulla is four times as much as dose in integrated kidney and beta dose in cortex is 0.004 to 0.012 times as much as beta dose in integrated kidney. Conclusion: Internal structure of kidney should be considered in simulation to achieve a more accurate prescribed dose. It is recommended that simulation results of three areas kidney are replaced with integrated kidney to prevent from renal toxicity.

  19. Depth profile of production yields of natPb(p, xn) 206,205,204,203,202,201Bi nuclear reactions

    Science.gov (United States)

    Mokhtari Oranj, Leila; Jung, Nam-Suk; Kim, Dong-Hyun; Lee, Arim; Bae, Oryun; Lee, Hee-Seock

    2016-11-01

    Experimental and simulation studies on the depth profiles of production yields of natPb(p, xn) 206,205,204,203,202,201Bi nuclear reactions were carried out. Irradiation experiments were performed at the high-intensity proton linac facility (KOMAC) in Korea. The targets, irradiated by 100-MeV protons, were arranged in a stack consisting of natural Pb, Al, Au foils and Pb plates. The proton beam intensity was determined by activation analysis method using 27Al(p, 3p1n)24Na, 197Au(p, p1n)196Au, and 197Au(p, p3n)194Au monitor reactions and also by Gafchromic film dosimetry method. The yields of produced radio-nuclei in the natPb activation foils and monitor foils were measured by HPGe spectroscopy system. Monte Carlo simulations were performed by FLUKA, PHITS/DCHAIN-SP, and MCNPX/FISPACT codes and the calculated data were compared with the experimental results. A satisfactory agreement was observed between the present experimental data and the simulations.

  20. Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion.

    Science.gov (United States)

    Fite, Kristen; Gomez-Cambronero, Julian

    2016-01-08

    Breast cancer is a leading cause of morbidity and mortality among women. Metastasis is initiated after epithelial-mesenchymal-transition (EMT). We have found a connection between EMT markers and the expression of four microRNAs (miRs) mediated by the signaling enzyme phospholipase D (PLD). Low aggressive MCF-7 breast cancer cells have low endogenous PLD enzymatic activity and cell invasion, concomitant with high expression of miR-203, -887, and -3619 (that decrease PLD2 translation and a luciferase reporter) and miR-182 (targeting PLD1) that are, therefore, "tumor-suppressor-like" miRs. The combination miR-887+miR-3619 abolished >90% of PLD enzymatic activity. Conversely, post-EMT MDA-MB-231 cells have low miR expression, high levels of PLD1/2, and high aggressiveness. The latter was reversed by ectopically transfecting the miRs, which was negated by silencing miRs with specific siRNAs. We determined that the molecular mechanism is that E-cadherin triggers expression of the miRs in pre-EMT cells, whereas vimentin dampens expression of the miRs in post-EMT invasive cells. This novel work identifies for the first time a set of miRs that are activated by a major pre-EMT marker and deactivated by a post-EMT marker, boosting the transition from low invasion to high invasion, as mediated by the key phospholipid metabolism enzyme PLD.

  1. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  2. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  3. Estrategias de enseñanza para el curso EIF-203 Estructuras discretas para informática a través del uso de las redes sociales Facebook y Twitter

    Directory of Open Access Journals (Sweden)

    Enrique Vílchez Quesada

    2014-05-01

    Full Text Available Recibido 29 de octubre de 2013 • Corregido 2 de marzo de 2014 • Aceptado 2 de abril de 2014. Este artículo corresponde a un trabajo científico derivado del proyecto de investigación en docencia adscrito a la Escuela de Informática de la Universidad Nacional de Costa Rica (UNA, titulado: Facebook como herramienta de enseñanza y aprendizaje para el curso EIF-203 Estructuras discretas para informática a través del uso de cuadernos interactivos. El objetivo general del proyecto consistió en analizar técnica y pedagógicamente la red social Facebook como un entorno de enseñanza y aprendizaje. En este documento se presenta una serie de estrategias de enseñanza creadas para complementar la docencia en el contexto del curso EIF-203, utilizando como plataforma educativa las redes sociales Facebook y Twitter. Las estrategias compartidas constituyen una intensa búsqueda de nuevas metodologías para mejorar los procesos de enseñanza e, idealmente, los procesos de aprendizaje en la materia EIF-203, integrada dentro del plan de estudios de la carrera Ingeniería en Sistemas de Información de la UNA. Estas fueron implementadas en un grupo de 31 estudiantes de la Sede Interuniversitaria de Alajuela, durante el I semestre 2013. Lo anterior permitió evaluar las estrategias de enseñanza desarrolladas utilizando una metodología de carácter cuantitativo. El instrumento empleado (un cuestionario se validó mediante una prueba de fiabilidad “Alfa de Cronbach” recurriendo a una muestra de 65 participantes. Los resultados obtenidos forman parte del análisis expuesto en el presente trabajo.

  4. Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).

    Science.gov (United States)

    Musilek, Kamil; Jun, Daniel; Cabal, Jiri; Kassa, Jiri; Gunn-Moore, Frank; Kuca, Kamil

    2007-11-01

    Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Among the organophosphates, with the exception of soman, tabun (GA) intoxications are the least responsive to treatment with commercially available therapeutics. A rational design was used to increase reactivation ability and decrease the toxicity of the novel reactivator. (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203) has better properties than previously tested compounds in vitro and, therefore, is a potential candidate for the treatment of GA intoxication in vivo.

  5. Croissance de fibres à gradient de concentration et analyse des processus dynamiques de transitions laser résonnantesdans Y203 dopé Er^{3+}, Yb^{3+} et Ho^{3+}

    Science.gov (United States)

    Laversenne, L.; Goutaudier, C.; Guyot, Y.; Cohen-Adad, M. Th.; Boulon, G.

    2002-06-01

    La croissance et l'exploitation de fibres à gradient de concentration de Y203 dopé par des ions terres rares permet d'étudier les processus dynamiques de transitions laser résonnantes des ions Yb^{3+}, Er^{3+} et Ho^{3+}. Plus particulièrement nous mettons en évidence et analysons les transferts d'énergie radiatifs (self trapping) responsables de l'allongement de la durée de vie expérimentale.

  6. A comparison of neuroprotective efficacy of two novel reactivators of acetylcholinesterase called K920 and K923 with the oxime K203 and trimedoxime in tabun-poisoned rats.

    Science.gov (United States)

    Kassa, Jiri; Misik, Jan; Hatlapatkova, Jana; Zdarova Karasova, Jana

    2017-01-22

    The ability of two newly developed bispyridinium oximes (K920, K923) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with the oxime K203 and trimedoxime using a functional observational battery (FOB). The neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose (130 μg/kg i.m.; 80% of LD50 value) were evaluated. Tabun-induced neurotoxicity was monitored by FOB at 2 h after tabun administration. The results indicate that all tested oximes combined with atropine enable tabun-poisoned rats to survive till the end of experiment while one non-treated tabun-poisoned rat died within 2 h. Both newly developed oximes (K920, K923) combined with atropine were able to markedly decrease tabun-induced neurotoxicity in the case of sublethal poisoning although they did not eliminate all tabun-induced acute neurotoxic signs and symptoms. Their ability to decrease tabun-induced acute neurotoxicity did not prevail the neuroprotective efficacy of trimedoxime and the oxime K203. Therefore, the newly developed oximes are not suitable for the replacement of currently available oximes (especially trimedoxime) in the treatment of acute tabun poisonings.

  7. Evaluation of the potency of two novel bispyridinium oximes (K456, K458) in comparison with oxime K203 and trimedoxime to counteract tabun-induced neurotoxicity in rats.

    Science.gov (United States)

    Kassa, Jiri; Misik, Jan; Karasova, Jana Z

    2013-09-01

    The ability of two newly developed bispyridinium oximes (K456, K458) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with oxime K203 and trimedoxime using the functional observational battery. The neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose (200 μg/kg i.m.; 85% of LD50 value) were evaluated. Tabun-induced neurotoxicity was monitored by the functional observational battery and automatic measurement of motor activity at 2 hr after tabun challenge. The results indicate that all tested oximes combined with atropine enable tabun-poisoned rats to survive till the end of experiment. Both newly developed oximes (K456, K458) combined with atropine were able to decrease tabun-induced neurotoxicity in the case of sublethal poisonings although they did not eliminate all tabun-induced acute neurotoxic signs and symptoms. Their ability to decrease tabun-induced acute neurotoxicity was slightly higher than that of trimedoxime and oxime K203, but the difference in neuroprotective efficacy among all oximes studied is not large enough to make a decision about replacement of commonly used oximes (especially trimedoxime and obidoxime) in the treatment of acute tabun poisonings.

  8. Simulation and optimization of the tower in a commercial vinyl acetate refining process%醋酸乙烯精制工艺中TQ-203塔的参数模拟优化与技术改造

    Institute of Scientific and Technical Information of China (English)

    李群生; 徐曼; 陈刚; 黄荣海; 徐凌云; 王宝华

    2013-01-01

    This paper targets the problem of handling capacity not meeting the production requirements and the high energy consumption in tower TQ-203 in a commercial vinyl acetate refining process.The process simulation software Aspen Plus was used simulate the vinyl acetate distillation tower,and the NRTL model which was close to the actual production parameters was selected.The number of theoretical plates used was 31.Orthogonal experimental analysis methods were used to obtain the best combination of the parameters to improve the design and operation parameters:the best location of the feed was found to be the 5 th theoretical plate,with a reflux ratio of 2.30,and the side cutting position at the 29th theoretical plate.Using the above parameters resulted in improvements and the production requirements being met.Two energy-saving measures including preheating the feed on the tower side and the side draw of TQ-205 heating the tower reactor of TQ-203 were proposed,which could reduce vapor (0.4 MPa) flow to 12.56 t/h and circulating cooling water flow to 434.54 t/h,resulting in economic benefits of 14.95 million yuan/a.%针对某工厂醋酸乙烯精制工艺TQ-203塔存在处理量不能满足生产要求、能耗较高的问题,运用流程模拟软件Aspen Plus对TQ-203塔进行模拟,选取最接近生产实际的NRTL模型,确定了理论板数为31块.由单因素分析给出了较优的参数范围,利用正交实验方法得到的最佳参数组合为:进料位置为第5块理论板,回流比为2.30,侧线采出位置为第29块理论板.根据上述结果提出对TQ-203塔更换塔板、调整进料及侧线采出位置的改进措施,能够满足该塔对处理量及产品纯度的生产要求;提出了侧线采出预热进料和采用第五精馏塔侧线采出做本塔塔釜热源的节能措施,该措施能节省水蒸汽(0.4MPa)12.56t/h、循环冷却水434.54t/h,可取得经济效益1495万元/a.

  9. A Search for Lepton-Flavor-Violating Decays of the 125 GeV Higgs Boson with Hadronically Decaying Tau Leptons in the 20.3 inverse fembtobarns using the $\\sqrt{s}=8$ TeV Dataset Collected in 2012 by the ATLAS Detector at the Large Hadron Collider

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00287453

    A Search for Lepton-Flavor-Violating Decays of the 125 GeV Higgs Boson with Hadronically Decaying Tau Leptons in the $20.3 fb^1$ proton-proton $\\sqrt{s}= 8$ TeV Dataset collected in 2012 by the ATLAS Detector at the Large Hadron Collider is reported.

  10. MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice

    Science.gov (United States)

    Lee, Benjamin P.; Burić, Ivana; George-Pandeth, Anupriya; Flurkey, Kevin; Harrison, David E.; Yuan, Rong; Peters, Luanne L.; Kuchel, George A.; Melzer, David; Harries, Lorna W.

    2017-01-01

    MicroRNAs (miRNAs) are small non-coding RNA species that have been shown to have roles in multiple processes that occur in higher eukaryotes. They act by binding to specific sequences in the 3’ untranslated region of their target genes and causing the transcripts to be degraded by the RNA-induced silencing complex (RISC). MicroRNAs have previously been reported to demonstrate altered expression in several aging phenotypes such as cellular senescence and age itself. Here, we have measured the expression levels of 521 small regulatory microRNAs (miRNAs) in spleen tissue from young and old animals of 6 mouse strains with different median strain lifespans by quantitative real-time PCR. Expression levels of 3 microRNAs were robustly associated with strain lifespan, after correction for multiple statistical testing (miR-203-3p [β-coefficient = −0.6447, p = 4.8 × 10−11], miR-664-3p [β-coefficient = 0.5552, p = 5.1 × 10−8] and miR-708-5p [β-coefficient = 0.4986, p = 1.6 × 10−6]). Pathway analysis of binding sites for these three microRNAs revealed enrichment of target genes involved in key aging and longevity pathways including mTOR, FOXO and MAPK, most of which also demonstrated associations with longevity. Our results suggests that miR-203-3p, miR-664-3p and miR-708-5p may be implicated in pathways determining lifespan in mammals. PMID:28304372

  11. Acute stressor exposure modifies plasma exosome-associated heat shock protein 72 (Hsp72 and microRNA (miR-142-5p and miR-203.

    Directory of Open Access Journals (Sweden)

    Lida A Beninson

    Full Text Available Exosomes, biologically active nanoparticles (40-100 nm released by hematopoietic and non-hematopoietic cells, contain a variety of proteins and small, non-coding RNA known as microRNA (miRNA. Exposure to various pathogens and disease states modifies the composition and function of exosomes, but there are no studies examining in vivo exosomal changes evoked by the acute stress response. The present study reveals that exposing male Fisher 344 rats to an acute stressor modulates the protein and miRNA profile of circulating plasma exosomes, specifically increasing surface heat shock protein 72 (Hsp72 and decreasing miR-142-5p and -203. The selected miRNAs and Hsp72 are associated with immunomodulatory functions and are likely a critical component of stress-evoked modulation of immunity. Further, we demonstrate that some of these stress-induced modifications in plasma exosomes are mediated by sympathetic nervous system (SNS activation of alpha-1 adrenergic receptors (ADRs, since drug-mediated blockade of the receptors significantly attenuates the stress-induced modifications of exosomal Hsp72 and miR-142-5p. Together, these findings demonstrate that activation of the acute stress response modifies the proteomic and miRNA profile of exosomes released into the circulation.

  12. Search for pair-produced top squarks decaying into a charm quark and the lightest neutralinos with 20.3 fb${}^{-1}$ of $pp$ collisions at $\\sqrt{s}=8~$TeV with the ATLAS detector at the LHC

    CERN Document Server

    The ATLAS collaboration

    2013-01-01

    This note presents the search for direct top squark pair production in the decay channel to a charm quark and the lightest neutralino ($\\tilde{t} \\to c + \\tilde{\\chi}_{1}^{0}$), using $20.3$~fb$^{-1}$ of proton-proton collision data at $\\sqrt{s} = 8$~TeV recorded by the ATLAS experiment at the LHC in 2012. The analysis is carried out in different signal regions according to the final state jet multiplicity. One of the regions uses charm-flavour identification to increase the signal purity. No excess above the Standard Model background expectation is observed. Limits are set on the visible cross-section of new physics within the requirements of the search. The results are interpreted in the context of direct pair production of top squarks and presented in terms of exclusion limits in the ($m_{\\tilde{t}}$, $m_{\\tilde{\\chi}_{1}^{0}}$) plane. A top squark mass of 200~GeV is excluded at 95$\\%$ confidence level for $m_{\\tilde{t}}$--$m_{\\tilde{\\chi}_{1}^{0}} < 85$~GeV. Top squark masses up to 230~GeV are excluded...

  13. Indirect immunofluorescence(IgG and IgM tests for toxoplasmosis on 203 persons, with no symptomatology suggesting the disease, located in the city of Rio de Janeiro. Serological follow up one to two years later.

    Directory of Open Access Journals (Sweden)

    Maria Regina Reis Amendoeira

    1981-12-01

    Full Text Available Clinical and serological follow up examinations were performed on 203 persons, from three to twenty years of age, from the otolaryngology department of a hospital in the city of Rio de Janeiro, with no symptomatology suggesting toxoplasmosis, but suffering from chronic tonsillitis. According to results obtained during the first indirect immunofluorescence tests, the patients were divided into following groups: Group I (non-reactive IgG and IgM, 98 persons (48.3%; Group II (1:16 ≤ IgG ≤ 1:256 and non-reactive IgM, 74 persons (36.5%; Group III (IgM ≥ 1:1024 and non-reactive IgM, 18 persons (8.8%, and Group IV (IgG and IgM reactive, 13 persons (6.4%. One to two years later, 131 (64.5% of the 203 persons were reexamined by a second indirect immunofluorescence test. In the case of 66 persons (Group I whose serum was non-reactive in the IgG and IgM classes during the first indirect immunofluorescence test, serum conversion was observed in aproximately 21.2%. in 65 individuals (49.6%, (Groups II, III and IV,with reactive serum in the IgG classes during the first indirect immunofluorescence test, the second reaction showed an increase in titres in 20% of the cases, a decrease in 67.7% of the cases, or no alterations in 12.3 of the cases. In the IgM class, all 131 sera were non-reactive at 116 dilution the second immunofluorescence test, including the 13 cases that had previously been reactive in the immunoglobulin class, Symptomatology suggesting toxoplasmosis was only observed in one case during the second testing, this patient's principal physical sign being hypertrophied lymph nodes. during this period, the Toxoplasma antibodies showed titres of IgG 1:32000 and non-reactive IgM, whilst one year previously, during the first test, these titres were IgG 1:1024 and IgM 1:64. Differences in the age, sex and skin coloring of patients were not statistically significant as regards alterations in the indirect immunofluorescence test titres.Foi feito o

  14. IgG三羰基锝[99mTc(CO)3(H20)3+]标记方法及其在动物体内的生物学分布%IgG radiolabelling with 99mTC by tricarbonyl method and its biodistribution in mice

    Institute of Scientific and Technical Information of China (English)

    池晓华; 黄宝丹; 汪兵; 黄凯; 李贵平

    2010-01-01

    目的 探索利用fac[99mTC(CO)3(H20)3]+中间体标记IgG的方法,了解99mTc(CO)3(H20)3-IgG在体内外的稳定性,并研究其在小鼠体内的生物分布情况.方法 自行合成fac-(99mTc(CO)3(H20)3]+中间体,并采用聚酰胺薄膜层析法测定其放化产率,利用放化中间体fac-[99mTc(CO)3(H20)3]+直接进行IgG的放射性标记,用纸层析法测定标记率及放化纯度.并分别观察99mTc标记IgG在人血清白蛋白(HSA)及生理盐水(NS)中的稳定性.取9只小白鼠,分别经尾静脉注人99mTc 标记IgG(3.7x104 Bq/100μl),于注药后2,4和12h分别先进行SPECT显像,然后处死小鼠分离各脏器,称重后测定放射性计数,计算各脏器每克组织百分注射剂量(%ID/g),结果fac-[99mTc(CO)3(H2O)3]+中间体的放化产率为82.48%,室温放置4h保持稳定.99mTc(CO)3(H20)3-IgG的标记率为57.04%,放化纯度均大于90%,在HSA中温育24h放化纯度保持稳定,而在NS中温育24h放化纯度则降为20%.体内生物分布显示99mTc(CO)3(H20)3-IgG在体内主要分布于肝、脾、肾,可较长时间存留于血池中.结论 利用放化中间体fac-[99mTc(CO)3(H20)3]+直接进行IgG放射性标记,具有良好的体内、外稳定性,在小鼠组织中分布特点符合IgG体内的放射性分布规律,可满足进一步的单抗及多肽标记的实验要求.

  15. Evaluation of Novel Wet Chemistry Separation and Purification Methods to Facilitate Automation of Astatine-­211 Isolation

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott [Univ. of Washington, Seattle, WA (United States)

    2016-07-19

    This research is a collaborative effort between the research groups of the PIs, Dr. D. Scott Wilbur in the Department of Radiation Oncology at the University of Washington (UW) and Matthew O’Hara at the Pacific Northwest National Laboratory (PNNL). In this report only those studies conducted at UW and the budget information from UW will be reported. A separate progress and financial report will be provided by PNNL. This final report outlines the experiments (Tasks) conducted and results obtained at UW from July 1, 2013 thru June 30, 2016 (2-­year project with 1 year no-­cost extension). The report divides the information on the experiments and results obtained into the 5 specific objectives of the research efforts and the Tasks within those objectives. This format is used so that it is easy to see what has been accomplished in each area. A brief summary of the major findings from the studies is provided below. Summary of Major Findings from Research/Training Activities at UW: Anion and cation exchange columns did not provide adequate 211At capture and/or extraction results under conditions studied to warrant further evaluation; PEG-­Merrifield resins containing mPEG350, mPEG750, mPEG2000 and mPEG5000 were synthesized and evaluated; All of the mPEG resins with different sized mPEG moieties conjugated gave similar 211At capture (>95%) from 8M HCl solutions and release with conc. NH4OH (~50-­80%), but very low quantities were released when NaOH was used as an eluent; Capture and release of 211At when loading [211At]astatate appeared to be similar to that of [211At]astatide on PEG columns, but further studies need to be conducted to confirm that; Capture of 211At on PEG columns was lower (e.g. 80-­90%) from solutions of 8M HNO3, but higher capture rates (e.g. 99%) can be obtained when 10M HNO3 is mixed with an equal quantity of 8M HCl; Addition of reductants to the 211At solutions did not appear to change the percent capture, but may have an effect on the % extracted; There was some indication that the PEG-­Merrifield resins could be saturated (perhaps with Bi) resulting in lower capture percentages, but more studies need to be done to confirm that; A target dissolution chamber, designed and built at PNNL, works well with syringe pumps so it can be used in an automated system; Preliminary semi-­automated 211At isolation studies have been conducted with full scale target dissolution and 211At isolation using a PEG column on the Hamilton automated system gave low overall recoveries, but HNO3 was used (rather than HCl) for loading the 211At and flow rates were not optimized; Results obtained using PEG columns are high enough to warrant further development on a fully automated system; Results obtained also indicate that additional studies are warranted to evaluate other types of columns for 211At separation from bismuth, which allow use of HNO3/HCl mixtures for loading and NaOH for eluting 211At. Such a column could greatly simplify the overall isolation process and make it easier to automate.

  16. Transect 20:3 (winter 2002)

    OpenAIRE

    2002-01-01

    IN THIS ISSUE OF TRANSECT - (feature article) Microbial Observatories Reveal Lively Little-Known Worlds Beneath the Surfaces of Land and Lake - Innovative Nesting Program at Coal Oil Point Reserve Proves Great Success - Stunt Ranch Reserve Looks Forward to New Facilities - Field Course Students from Minnesota Discover California Ecology at NRS Reserves

  17. 49 CFR 180.203 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... replacement of a pressure part (e.g. a wall, head, or pressure fitting) by welding. Rejected cylinder means a... using the water jacket or direct expansion methods: (1) Water jacket method means a volumetric expansion... volume of water the cylinder externally displaces at test pressure and the volume of water the...

  18. Reference: 203 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available cently, two pathways of crossover formation have been identified on the basis of distinct genetic controls. In one pathway, crossover...ance-dependent manner. This phenomenon is known as interference. The second kind of crossover is insensitive... to interference. The two pathways function independently in budding yeast. Only interference-insensitive crossover...s occur in Schizosaccharomyces pombe. In contrast, only interference-sensitive crossover... one of the genes shown to be required for the formation of interference-sensitive crossovers in Saccharomyc

  19. 33 CFR 203.12 - Authority.

    Science.gov (United States)

    2010-07-01

    ... alternatives thereto; emergency protection of federally authorized hurricane or shore protection projects which are threatened, when such protection is warranted to protect against imminent and substantial loss to life and property; and repair and restoration of federally authorized hurricane or shore...

  20. 33 CFR 203.15 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Washington, D.C. Hurricane/Shore Protection Project (HSPP). A flood control project designed and constructed... projects known as shore protection projects, shore protection structures, periodic nourishment projects, shore enhancement projects, and similar terms. Components of an HSPP may include both hard...

  1. 48 CFR 370.203 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... member of the Tribe. (b) Indian Tribe means an Indian Tribe, pueblo, band, nation, or other organized...), which is recognized as eligible for the special programs and services provided by the United States to... Financing Act of 1974 (88 Stat. 77, 25 U.S.C. 1451). (d) Indian-owned economic enterprise means any...

  2. 49 CFR 372.203 - Beaumont, TX.

    Science.gov (United States)

    2010-10-01

    ... and is comprised of all points as follows: (a) The municipality of Beaumont, Tex., itself; (b) All... County and Orange County, Tex.; (d) All of any municipality any part of which is within the limits of the combined areas defined in paragraphs (b) and (c) of this section, and (e) All of any municipality...

  3. 50 CFR 223.203 - Anadromous fish.

    Science.gov (United States)

    2010-10-01

    ... contractors of the ODFW, WDFW (Agencies), IDFG, or CDFG (Agencies), or as a part of a monitoring and research... Screening Criteria for Anadromous Salmonids, January 1997” or with any subsequent revision. (ii) The owner... require a commitment of compensatory mitigation if implementation of the plan and schedule is...

  4. 42 CFR 37.203 - Autopsy specifications.

    Science.gov (United States)

    2010-10-01

    ... the ventricular surface and shall not include trabeculations or pericardial fat. The right ventricle... diaphragm; (vii) From each type of suspected pneumoconiotic lesion, representative microscopic slides... block of tissue; a minimum of three stained slides and three blocks of tissue shall be submitted....

  5. BDML Metadata: 203 [SSBD[Archive

    Lifescience Database Archive (English)

    Full Text Available tal Dynamics See details in Kyoda et al. (2013) Nucleic Acids Res 41, D732-D737. CC BY-NC-SA 0.180 bbc0402b-...tp://ssbd.qbic.riken.jp/search/bbc0402b-d0d2-4873-9883-a71dc1108884/ http://ssbd.qbic.riken.jp/omero/webclient/?show=dataset-152 ...

  6. 18 CFR 1304.203 - Vegetation management.

    Science.gov (United States)

    2010-04-01

    ... corridor. (k) Planting of trees, shrubs, wildflowers, native grasses, and ground covers within the SMZ is... located to minimize removal of trees or other vegetation on the TVA land. (d) Grass may be planted and... steps are allowed. Pruning of side limbs that extend into the access corridor from trees located...

  7. 40 CFR 211.203 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... interchangeably with -the terms, “hearing protector” and -“device.” (n) Impulsive Noise. An acoustic event... giving noise reduction effectiveness information appropriate to the product. (p) Manufacturer. As stated... with the distribution of such products.” (q) Noise Reduction Rating (NRR). A single number...

  8. 7 CFR 1205.203 - Voting eligibility.

    Science.gov (United States)

    2010-01-01

    ... husband or a wife is eligible to vote if he or she shares with his or her spouse in the proceeds of the... rent or share tenant. Thus, if a husband and wife are tenants or sharecropper on a farm, jointly... rental or sharecropping agreement is written, signed by both parties, or oral, provided both husband...

  9. 31 CFR 203.2 - Definitions.

    Science.gov (United States)

    2010-07-01

    ..., capacity means the dollar amount of collateral that the depositary has pledged for SDIs under a BIC...-bearing note maintained on the books of the Treasury Support Center representing the amount of SDIs...

  10. 10 CFR 600.203 - Applicability.

    Science.gov (United States)

    2010-01-01

    ..., Drug Abuse, and Mental Health Services; Maternal and Child Health Services; Social Services; Low-Income...), Alcohol and Drug Abuse Treatment and Rehabilitation Block Grant and part C of Title V, Mental Health...) of the Refugee Education Assistance Act of 1980 (Pub. L. 96-422, 94 Stat. 1809), for cash...

  11. 31 CFR 203.1 - Scope.

    Science.gov (United States)

    2010-07-01

    ... Federal tax payments may do so through the paper tax system (PATAX), or Electronic Federal Tax Payment... TREASURY FINANCIAL MANAGEMENT SERVICE PAYMENT OF FEDERAL TAXES AND THE TREASURY TAX AND LOAN PROGRAM... institutions of electronic and paper-based deposits and payments of Federal taxes; the operation of...

  12. 20 CFR 655.203 - Assurances.

    Science.gov (United States)

    2010-04-01

    ... WORKERS IN THE UNITED STATES Labor Certification Process for Logging Employment and Non-H-2A Agricultural... least the adverse effect wage rate; give the 3/4 guarantee; state that work tools, supplies...

  13. 22 CFR 203.2 - Definitions.

    Science.gov (United States)

    2010-04-01

    ....2 Definitions. As used in this part: (a) Cooperative Development Organization (CDO) means an... Voluntary Organization (LPVO) means a non-U.S. based PVO that meets the definition of an International... nonprofit or profit-making. (i) Nonprofit organization means any corporation, trust,...

  14. China Report: Science and Technology, Number 203.

    Science.gov (United States)

    2007-11-02

    the authors improved it with 25w, 30s ultrasonic treat- ment. When the bovine thymus DNA, a high-polymer product of jSerya Feinbiochemica Heidelberg...thod is adopted by Jilin Industrial University, Jilin Chemical Industry Company, Taiyuan Xinhua Chemical Plant , etc; the 2nd by Changchun Research...Institute of Mo- tor Vehicles, Beijing Research Insttute of Motor Vehicles, Beijing Experimental Chemistry Plant , Research Institute of Engineering

  15. 5 CFR 9901.203 - Waivers.

    Science.gov (United States)

    2010-01-01

    ... for members of the SES and employees in SL/ST positions), and 5 U.S.C. 6304(f) (regarding annual leave... Administrative Personnel DEPARTMENT OF DEFENSE HUMAN RESOURCES MANAGEMENT AND LABOR RELATIONS SYSTEMS (DEPARTMENT OF DEFENSE-OFFICE OF PERSONNEL MANAGEMENT) DEPARTMENT OF DEFENSE NATIONAL SECURITY PERSONNEL...

  16. 5 CFR 2640.203 - Miscellaneous exemptions.

    Science.gov (United States)

    2010-01-01

    ... arises from Federal Government or Federal Reserve Bank salary or benefits, or from Social Security or... employment of relatives at 5 U.S.C. 3110. (e) Commercial discount and incentive programs. An employee may... policy. The amount of the dividend is based upon the company's overall profitability. Nevertheless,...

  17. 47 CFR 20.3 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES COMMERCIAL MOBILE RADIO.... Commercial mobile radio service. A mobile service that is: (a)(1) provided for profit, i.e., with the intent... service that is neither a commercial mobile radio service nor the functional equivalent of a service...

  18. 49 CFR 232.203 - Training requirements.

    Science.gov (United States)

    2010-10-01

    ... training curriculum that covers the skills and knowledge the employee will need to possess in order to... satisfaction of the employee's supervisor or designated instructor; (6) An employee hired or working prior to... if the employee receives training and testing on the specific Federal regulatory...

  19. 5 CFR 2635.203 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... incurred. It does not include: (1) Modest items of food and refreshments, such as soft drinks, coffee and... benefits, including favorable rates and commercial discounts, available to the public or to a class... required as part of his official duties; (6) Pension and other benefits resulting from...

  20. 50 CFR 665.203 - Permits.

    Science.gov (United States)

    2010-10-01

    .... If one or more persons on a vessel-based bottomfish fishing trip holds an MHI non-commercial permit... fishing occurs during or as a result of a vessel-based fishing trip, then the fishing trip is considered... incapacitation, vessel breakdowns, and the loss of the vessel at sea if the event prevented the vessel...

  1. 32 CFR 203.10 - Eligible activities.

    Science.gov (United States)

    2010-07-01

    ... reports include, but are not limited to: (i) Installation restoration program site studies, engineering documents, such as site inspections, remedial investigations, feasibility studies, engineering evaluation..., including baseline and ecological risk assessments conducted by the installation; and (iii)...

  2. 5 CFR 250.203 - Agency responsibilities.

    Science.gov (United States)

    2010-01-01

    ... the assessment of the management of human capital in the Federal Government, and to help meet the... current state, projects the human resources needed to achieve the agency's program performance goals and... development of human capital goals and objectives during the agency's strategic planning and...

  3. 14 CFR 417.203 - Compliance.

    Science.gov (United States)

    2010-01-01

    ... for any change to the flight safety analysis method. A licensee must file any material change with the... safety analysis must also meet the requirements for methods of analysis contained in appendices A and B of this part for a launch vehicle flown with a flight safety system and appendices B and C of...

  4. 40 CFR 90.203 - General provisions.

    Science.gov (United States)

    2010-07-01

    ... should have reason to believe that such engines have been or will be imported in a piece of equipment; or... Enforcement Audit (SEA) failure, credits may be used to cover subsequent production of engines for the...

  5. 24 CFR 203.200 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... collapsible soils. Damage to the following nonload-bearing portions of the home is not considered a structural... items, not a part of the structure, which are damaged by the defect or as a result of the defect....

  6. 10 CFR 26.203 - General provisions.

    Science.gov (United States)

    2010-01-01

    ... comprehensive examination required in § 26.29(b): (1) Knowledge of the contributors to worker fatigue, circadian... to the work hour controls in § 26.205; (2) Records of shift schedules and shift cycles of...

  7. 33 CFR 203.32 - Policy.

    Science.gov (United States)

    2010-07-01

    ... provided to supplement State and local efforts. The Corps will not perform ice jam blasting operations for... arrive within a day or two) likely to cause additional flooding. (3) Removal of ice jams is a...

  8. 24 CFR 92.203 - Income determinations.

    Science.gov (United States)

    2010-04-01

    ... low-income families for the family size of the tenant and state that the tenant's annual income does... Security Income, Aid to Families with Dependent Children, or other public assistance or public welfare... for very low-income families established under § 92.252(b)(2) are based on adjusted income....

  9. 48 CFR 31.203 - Indirect costs.

    Science.gov (United States)

    2010-10-01

    ... contract or other work, indirect costs are those remaining to be allocated to intermediate or two or more... basis of the benefits accruing to intermediate and final cost objectives. When substantially the same... for allocating indirect costs is the cost accounting period during which such costs are incurred...

  10. 48 CFR 52.203-3 - Gratuities.

    Science.gov (United States)

    2010-10-01

    ... as in a breach of the contract; and (2) In addition to any other damages provided by law, to... to any other rights and remedies provided by law or under this contract. (End of clause) ... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses...

  11. Therapeutic intervention of silymarin on the migration of non-small cell lung cancer cells is associated with the axis of multiple molecular targets including class 1 HDACs, ZEB1 expression, and restoration of miR-203 and E-cadherin expression.

    Science.gov (United States)

    Singh, Tripti; Prasad, Ram; Katiyar, Santosh K

    2016-01-01

    Lung cancer and its metastasis is the leading cause of cancer-related mortality world-wide. Non-small cell lung cancer (NSCLC) accounts for about 90% of total lung cancer cases. Despite advancements in therapeutic approaches, only limited improvement has been achieved. Therefore, alternative strategies are required for the management of lung cancer. Here we report the chemotherapeutic effect of silymarin, a phytochemical from milk thistle plant (Silybum marianum L. Gaertn.), on NSCLC cell migration using metastatic human NSCLC cell lines (A549, H1299 and H460) together with the molecular targets underlying these effects. Using an in vitro cell migration assay, we found that treatment of human NSCLC cells (A549, H1299 and H460) with silymarin (0, 5, 10 and 20 µg/mL) for 24 h resulted in concentration-dependent inhibition of cell migration, which was associated with the inhibition of histone deacetylase (HDAC) activity and reduced levels of class 1 HDAC proteins (HDAC1, HDAC2, HDAC3 and HDAC8) and concomitant increases in the levels of histone acetyltransferase activity (HAT). Known HDAC inhibitors (sodium butyrate and trichostatin A) exhibited similar patterns of therapeutic effects on the lung cancer cells. Treatment of A549 and H460 cells with silymarin reduced the expression of the transcription factor ZEB1 and restored expression of E-cadherin. The siRNA knockdown of ZEB1 also reduced the expression of HDAC proteins and enhanced re-expression of the levels of E-cadherin in NSCLC cells. MicroRNA-203 (miR-203) acts as a tumor suppressor, regulates tumor cell invasion and is repressed by ZEB1 in cancer cells. Silymarin treatment restored the levels of miR-203 in NSCLC cells. These findings indicate that silymarin can effectively inhibit lung cancer cell migration and provide a coherent model of its mechanism of action suggesting that silymarin may be an important therapeutic option for the prevention or treatment of lung cancer metastasis when administered either

  12. Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

    Energy Technology Data Exchange (ETDEWEB)

    Green, Damian J.; Shadman, Mazyar; Jones, Jon C.; Frayo, Shani; Kenoyer, Aimee L.; Hylarides, Mark; Hamlin, Donald K.; Wilbur, D. Scott; Balkan, Ethan R.; Lin, Yukang; Miller, Brian W.; Frost, Sophia; Gopal, Ajay K.; Orozco, Johnnie J.; Gooley, Ted; Laird, Kelley L.; Till, B. G.; Back, Tom; Sandmaier, B. M.; Pagel, John M.; Press, Oliver W.

    2015-03-26

    Alpha emitting radionuclides release a large amount of energy within a few cell diameters and may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD) conditions in which micrometastatic disease satellites are broadly distributed. To evaluate this hypothesis, 211At conjugated 1F5 mAb (anti-CD20) was studied in both bulky lymphoma tumor xenograft and MRD animal models. Superior treatment responses to 211At conjugated 1F5 mAb were evident in the MRD setting. Lymphoma xenograft tumor bearing animals treated with doses of up to 48µCi of anti-CD20 211At-decaborate [211At-B10-1F5] experienced modest responses (0% cures but 2-3-fold prolongation of survival compared to negative controls). In contrast, 70% of animals in the MRD lymphoma model demonstrated complete eradication of disease when treated with 211At-B10-1F5 at a radiation dose that was less than one-third (15 µCi) of the highest dose given to xenograft animals. Tumor progression among untreated control animals in both models was uniformly lethal. After 130 days, no significant renal or hepatic toxicity is observed in the cured animals receiving 15 µCi of 211At-B10-1F5. These findings suggest that in a MRD lymphoma model, where isolated cells and tumor microclusters prevail, α-emitters may be uniquely efficacious.

  13. A Search for Lepton-Flavor-Violating Decays of the 125 GeV Higgs Boson with Hadronically Decaying Tau Leptons in the 20.3 fb$^{-1}$, $\\sqrt{s} = 8$ TeV Dataset Collected in 2012 by the ATLAS Detector at the Large Hadron Collider

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00287453

    This dissertation presents a search for lepton-flavor-violating (LFV) decays of the 125 GeV Higgs boson in final states of $\\mu\\tau_{\\mathrm{had}}$ and $e\\tau_{\\mathrm{had}}$ in the full dataset collected by the ATLAS detector in 2012. The search is based on data samples of proton--proton collisions at $\\sqrt{s} = 8$ TeV, corresponding to an integrated luminosity of 20.3 fb$^{-1}$. The topology of LFV events is exploited through an optimized selection of objects and events, with signal and control regions defined by event kinematics. A binned likelihood fit searching for the presence of LFV Higgs decays is performed using the reconstructed Higgs boson mass as the discriminating variable. No such decays are observed. The expected (observed) upper limits at $95\\%$ confidence on the branching ratios for the muon and electron final states are found to be $\\mathrm{Br}(H \\rightarrow \\mu\\tau) = 1.24\\%~(1.85\\%)$ and $\\mathrm{Br}(H \\rightarrow e\\tau) = 2.07\\%~(1.81\\%)$.

  14. Effects of ZnO addition on mechanical properties of Bi{sub 1.84}Pb{sub 0.34}Sr{sub 1.91}Ca{sub 2.03}Cu{sub 3.06}O{sub 10} prepared by a wet technique

    Energy Technology Data Exchange (ETDEWEB)

    Karaca, I. [Department of Physics, Faculty of Science and Arts, Nigde University, 51200 Nigde (Turkey)], E-mail: ikaraca38@hotmail.com; Uzun, O.; Koelemen, U.; Yilmaz, F. [Department of Physics, Faculty of Science and Arts, Gaziosmanpasa University, 60240 Tokat (Turkey); Sahin, O. [Department of Physics, Faculty of Science and Arts, Mustafa Kemal University, 31034 Hatay (Turkey)

    2009-05-12

    In this study, ZnO molar wt% 0, 5, 10, 20, 30, and 50 added Bi{sub 1.84}Pb{sub 0.34}Sr{sub 1.91}Ca{sub 2.03}Cu{sub 3.06}O{sub 10} superconductors were prepared by wet technique. The experimental works consist of powder X-ray diffraction (XRD) for phase analyses and c-axes parameters, scanning electron microscopy (SEM) for microstructure examination, and microhardness measurements for mechanical properties. These measurements showed that Zn-added material, in comparison with the pure sample, had increased c-axes parameters and decreased grain size. In addition, the experimental results of microhardness measurements were analyzed using Oliver-Pharr model. It was observed that the change of indentation hardness (H{sub IT}) and reduced elastic modulus (E{sub r}) values showed an increasing trend with ZnO addition and exhibited peak load dependence (i.e., indentation size effect (ISE))

  15. Dicty_cDB: SHG203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available H_new03_P06 Bicyclus anynana wings - 5TH instar larvae Bicyclus anynana cDNA 3', mRNA sequence. 36 5.5 2 DY7...71880 |DY771880.1 5TH_new03_J24 Bicyclus anynana wings - 5TH instar larvae Bicyclus anynana cDNA 3', mRNA se

  16. Dicty_cDB: CHQ203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ete sequence. 100 7e-17 1 DT364098 |DT364098.1 JGI_ANNN9278.rev ANNN Pimephales promelas Whole (L) Pimephales promelas... cDNA clone ANNN9278 3', mRNA sequence. 48 0.22 1 DT347978 |DT347978.1 JGI_CAAX10802.fwd CAAX Pimephales promelas... testis 7-8 month adults, males and females pooled (L) Pimephales promelas... cDNA clone CAAX10802 5', mRNA sequence. 48 0.22 1 DT309975 |DT309975.1 JGI_CAAX1517.fwd CAAX Pimephales promelas... testis 7-8 month adults, males and females pooled (L) Pimephales promelas cDNA clone CAAX1517

  17. 48 CFR 552.203-71 - Restriction on Advertising.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Restriction on Advertising... Restriction on Advertising. As prescribed in 503.570-2, insert the following clause: Restriction on Advertising (SEP 1999) The Contractor shall not refer to this contract in commercial advertising or...

  18. 48 CFR 15.203 - Requests for proposals.

    Science.gov (United States)

    2010-10-01

    ... information regarding cost comparisons between Government and contractor performance. (c) Electronic commerce... RFP shall specify the electronic commerce method(s) that offerors may use (see subpart 4.5). (d... and suitability of electronic commerce methods; and (iv) Adequacy of administrative procedures...

  19. 1935 15' Quad #203 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  20. 40 CFR 61.203 - Radon monitoring and compliance procedures.

    Science.gov (United States)

    2010-07-01

    ..., each owner or operator of an inactive phosphogypsum stack shall test the stack for radon-222 flux in... the radon-222 flux testing. Each report shall also include the following information: (i) The name and... provide EPA with a report detailing the actions taken and the results of the radon-222 flux testing....

  1. 38 CFR 20.3 - Rule 3. Definitions.

    Science.gov (United States)

    2010-07-01

    .... (h) Electronic hearing means a hearing on appeal in which an appellant or a representative participates, through voice transmission or through picture and voice transmission, by electronic or other... agency of original jurisdiction being appealed. (j) Law student means an individual pursuing a...

  2. 24 CFR 203.357 - Deed in lieu of foreclosure.

    Science.gov (United States)

    2010-04-01

    ... deed in lieu of foreclosure from a corporate mortgagor in compliance with the requirements of paragraph... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... foreclosure, the mortgagee may acquire property from one other than a corporate mortgagor by...

  3. 40 CFR 240.203-2 - Recommended procedures: Design.

    Science.gov (United States)

    2010-07-01

    ... considered in the design. (c) The facility should be designed to be compatible with the surrounding area, easy to maintain, and consistent with the land use of the area. (d) Employee convenience facilities and plant maintenance facilities should be provided. Adequate lighting should be provided throughout...

  4. 19 CFR 201.203 - Delegation of authority.

    Science.gov (United States)

    2010-04-01

    ... Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Debt... consumer reporting agencies certain data pertaining to delinquent debts; (d) Use offset procedures to... accordance with the policies contained herein and as otherwise provided by law....

  5. Preface: phys. stat. sol. (a) 203/12

    Science.gov (United States)

    Jackman, Richard B.; Nesládek, Milo; Haenen, Ken

    2006-09-01

    The 30 papers gathered in this issue of physica status solidi (a) give a thorough overview over different topics that were presented during the 11th edition of the International Workshop on Surface and Bulk Defects in CVD Diamond Films (SBDD), which took place from 22 to 24 February 2006, at the Hasselt University in Diepenbeek-Hasselt, Belgium. Since its start more than 10 years ago, the SBDD Workshop has grown into a well-established, yearly early bird meeting place, addressing new emerging science related to the progress in the CVD diamond field. The 10 invited lectures, 29 contributed oral presentations and 26 posters were presented in several sessions during an intense two and a half day long meeting.The number of participants reached 115 this year with participants coming from fifteen countries: Austria, Belgium, Czech Republic, France, Germany, Israel, Italy, Japan, Mexico, Poland, Russia, Singapore, Slovak Republic, Sweden, UK, and USA. The mixture of young and established scientists, including a great proportion of students, made this meeting a hot spot of lively discussions on a wide range of scientific subjects, not only during the meeting itself, but also at several occasions throughout many social events offered by the hospitality of the city of Hasselt.It stands for itself that the workshop would not have been possible without the support of many people and institutions. For financial aid we are especially indebted to the Scientific Research Community Surface Modification of Materials of the F.W.O.-Vlaanderen (Belgium), whose incessant support plays an important role in keeping this meeting going. We also thank the Hasselt University for offering the lecture hall and infrastructure facilities and Seki Technotron Corp. for sponsoring the poster reception and their presence with a table top exhibit. Finally we highly appreciate the active approach of the editorial staff of physica status solidi in this conference and would like to thank most notably Stefan Hildebrandt, Ron Schulz-Rheinländer, Christoph Lellig, and Julia Hübner, for their excellent and patient work, bringing the number of successfully published proceedings of SBDD in pss (a) up to 8 already!To finish, we would all like to invite you to the 12th edition of the SBDD series, newly renamed as Hasselt Diamond Workshop, to be held at its established location of Diepenbeek-Hasselt. We look forward meeting you again at SBDD XII in 2007:Hasselt Diamond Workshop - SBDD XII28 February-2 March 2007Hasselt University, Diepenbeek-Hasselt, Belgiumhttp://www.imo.uhasselt.be/SBDD2007London, Paris, Hasselt, August 2006

  6. 48 CFR 28.203-7 - Exclusion of individual sureties.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Exclusion of individual... Exclusion of individual sureties. (a) An individual may be excluded from acting as a surety on bonds... of protecting the Government. (b) An individual may be excluded for any of the following causes:...

  7. Dicty_cDB: SFE203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available viimdesfnsilepenawlflfddvsqlqqlpivqnnqenfinsidf ntgdvtttnisglnfqsleeslnsdtsienkpq...i Frame C: ilktviiykqciiviimdesfnsilepenawlflfddvsqlqqlpivqnnqenfinsidf ntgdvtttnisglnfqsleeslnsdtsienkpqiie

  8. 12 CFR 303.203 - Applications for capital distributions.

    Science.gov (United States)

    2010-01-01

    ... requires an application under section 18(i) of the FDI Act (12 U.S.C. 1828(i)) as implemented by § 303.241... with, or made a part of, the application filed pursuant to section 38 of the FDI Act (12 U.S.C. 1831o)....

  9. 24 CFR 203.49 - Eligibility of adjustable rate mortgages.

    Science.gov (United States)

    2010-04-01

    ... National Housing Act. (a) Types of mortgages insurable. The types of adjustable rate mortgages that are... payment, except that, for these types of mortgages, the first adjustment shall be no sooner or later than... secured by a principal dwelling under the Truth in Lending Act, 15 U.S.C. 1601 et seq. (h)...

  10. 31 CFR 203.3 - TT&L depositaries.

    Science.gov (United States)

    2010-07-01

    ... accept electronic Federal tax payments, but does not accept direct investments or SDIs. A retainer... that accepts direct investments, SDIs, or dynamic investments and may accept electronic and/or...

  11. 31 CFR 203.20 - Investment account requirements.

    Science.gov (United States)

    2010-07-01

    ... direct investments, SDIs, term investments, or other investment programs. (c) Withdrawals. The amount of... balance limit. (3) SDIs. SDIs are credited to the SDI account balance and are not considered in...

  12. 31 CFR 203.21 - Collateral security requirements.

    Science.gov (United States)

    2010-07-01

    ... limit to obtain the depositary's maximum portion of the same-day direct investment. (3) SDIs. The day before SDIs are credited to an investor depositary's SDI account balance, the depositary must pledge..., to cover the total of the SDIs to be received. (4) TIO. Each depositary participating in the...

  13. 24 CFR 203.18 - Maximum mortgage amounts.

    Science.gov (United States)

    2010-04-01

    ... as of the date the mortgage is accepted for insurance. (e) Disaster victims. A mortgage covering a... is required as a result of a flood, fire, hurricane, earthquake, storm, riot or civil disorder...

  14. 49 CFR 377.203 - Extension of credit to shippers.

    Science.gov (United States)

    2010-10-01

    ... end of the extended credit period if, in consideration therefor, they include any published service... unjust discrimination between similarly situated shippers and/or consignees; (iii) Shall be applied...

  15. 28 CFR 55.6 - Coverage under section 203(c).

    Science.gov (United States)

    2010-07-01

    ... THE VOTING RIGHTS ACT REGARDING LANGUAGE MINORITY GROUPS Nature of Coverage § 55.6 Coverage under... citizens are members of a single language minority group and are limited-English proficient; and (ii) The illiteracy rate of such language minority citizens in the political subdivision is higher than the...

  16. 28 CFR 16.203 - Closed meetings-Formal procedure.

    Science.gov (United States)

    2010-07-01

    ... obtained from any person, corporation, business, labor or pension organization, which is privileged or... lawful national security intelligence investigation, confidential information furnished only by the... certificates of exemption under the Labor-Management Reporting and Disclosure Act of 1959 and the...

  17. 48 CFR 28.203 - Acceptability of individual sureties.

    Science.gov (United States)

    2010-10-01

    ... bond obligations) pledged by the individual surety, must equal or exceed the penal amount of each bond..., must equal or exceed the penal amount of the bond. Each individual surety must accept both joint and several liability to the extent of the penal amount of the bond. (c) If the contracting officer...

  18. Dicty_cDB: AFI203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available d sequence (All Frames) Frame A: ---xsxsslfxsxxfxfxxs*ktrxf*xxlxxdwgpsxgmlxixkxxxxkixsx Frame B: ---XVXQACLXXGIFXS...2 Translated Amino Acid sequence ---XVXQACLXXGIFXSXQVKKPGIFXIXXXGTGALPGACWXXKKXAKXKFXXX Translated Amino Aci

  19. 49 CFR 172.203 - Additional description requirements.

    Science.gov (United States)

    2010-10-01

    ..., there must be entered for— (1) Anhydrous ammonia. (i) The words “0.2 PERCENT WATER” to indicate the... transportation as “limited quantity,” as authorized by this subchapter, must include the words “Limited Quantity... labels. (6) For a package containing fissile Class 7 (radioactive) material: (i) The words...

  20. Dicty_cDB: SHL203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available C8, complete sequence. 48 0.39 1 DY882957 |DY882957.1 AresSEQ12202 Amorphotheca resina...e pBluescript (EcoRI-XhoI) Amorphotheca resinae cDNA clone AresSEQ12202, mRNA sequence. 46 1.5 1 dna up

  1. 24 CFR 203.389 - Waived title objections.

    Science.gov (United States)

    2010-04-01

    ... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES... therewith; (k) Violations of cost or set back restrictions which do not provide a penalty of reversion...

  2. 20 CFR 429.203 - When is a claim allowable?

    Science.gov (United States)

    2010-04-01

    ... paragraph (a) of this section and the other provisions of this subpart, any claim you make for damage to, or... excluded under this subpart: (1) Property damage in quarters or other authorized places. Claims are allowable for damage to, or loss of, property arising from fire, flood, hurricane, other natural...

  3. Dicty_cDB: VHI203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available s producing significant alignments: (bits) Value AF325215_2( AF325215 |pid:none) Lymphocytic choriomeningitis...5090 |pid:none) Schistosoma japonicum SJCHGC03255 ... 36 2.8 EU480452_2( EU480452 |pid:none) Lymphocytic choriomeningitis...325214_2( AF325214 |pid:none) Lymphocytic choriomeningitis virus... 35 8.2 BX2941

  4. Preparation and characterization of Cr203 system optically variable pigment

    Institute of Scientific and Technical Information of China (English)

    DU Haiyan; ZHANG Hua; CHEN Qirong; SUN Jiayue; XU Wencai; MA Erjun

    2007-01-01

    An optically variable pigment was produced by wet chemical method, where TiO2-coated mica with interfer-ence colors acted as the substrate materials. The structure of the pigment was characterized by X-ray diffraction (XRD),and its optically variable effect was investigated by X-Rite MA86 Ⅱ five angles spectrophotometer. The impact of differ-ent interference substrate materials for improving the color travel effect was studied, and the influence of white and black background on the hue and the color travel effect were stud-ied. Results showed that optically variable pigments can be prepared by coating Cr2O3 on the surface of the pretreated TiO2-coated mica. The color travel effect was sensitive to the change of substrate materials, and different backgrounds can influence the hue and the color travel effect of the pigment.

  5. Preface: phys. stat. sol (a) 203/9

    Science.gov (United States)

    Duewski, P.; Bristowe, P.; Maurice, J.-L.; Komninou, P.

    2006-07-01

    This special issue contains a selection of papers that were presented at a symposium on Interfacial Processes and Properties of Advanced Materials (IPAM05) held at the E-MRS Fall Meeting, Warsaw, Poland on 5-7 September 2005. The symposium was conceived and inspired by the success of its predecessor (IPAM04) held at the University of Caen, France in June 2004.The symposium attracted over sixty contributions and was organized around five areas: Interfaces and dislocations in compound semiconductors, Gate oxide interfaces, Interfaces and defects in electroceramics, Metal-metal interfaces and interfacial modeling, and Interfaces in nano-structured and amorphous thin-film systems. The focus was on the influence of buried interfaces on the functionality of various electronic and opto-electronic devices such as lasers, ferroelectric memories, CMOS and magnetic disks. Therefore the materials addressed at the symposium included compound semiconductors (e.g. GaN, CdTe, ZnO), perovskites (e.g. SrTiO3), dielectrics (e.g. HfO2, SiO2, Al2O3), and metals (e.g. Fe/V superlattices). The aim of the symposium was to bring together leading interface experts, both experimental and theoretical, to explore the connection between interfacial properties (atomic and electronic structure, segregation, diffusion, kinetics) and materials performance in a device application. Papers were presented that described the use of a variety of sophisticated experimental techniques to explore the interfacial properties including HRTEM, X-ray high-resolution diffraction, Raman spectroscopy, STM, AFM, PL spectroscopy, SIMS and electrical and magnetic measurements. The theoretical work included applications of density functional theory, atomistic simulations, dislocation theory and finite element modeling. The program stimulated many exciting and productive discussions between experimentalists and theorists. The ultimate objective was to improve our knowledge of the role of interfaces on the properties of current and emerging device materials. It is hoped that these proceedings represent a step towards that goal and will encourage further conferences in this area in the future.The organisers gratefully acknowledge funding from the US Office of Naval Research Global (ONRG) Conference Support Program. They also would like to thank E-MRS for their administrative support and the Institute of Physics, Polish Academy of Sciences and the Warsaw University of Technology for hosting the symposium.

  6. 12 CFR Supplement I to Part 203 - Staff Commentary

    Science.gov (United States)

    2010-01-01

    ... so in order to enhance its utility to users. Paragraph 5(e) Notice of availability. 1. Poster... action notices. 3. Requests for preapproval. To be a covered preapproval program, the written commitment... 2010, the asset-size exemption threshold is $39 million. Depository institutions with assets at...

  7. Dicty_cDB: CFC203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available a ... 40 0.17 EF084406_1( EF084406 |pid:none) Picea sitchensis clone WS02712_K12... 39 0.38 ( P56873 ) RecName: Full=Sjoe... days embryo whole ... 37 1.4 ( O60232 ) RecName: Full=Sjoegren syndrome/scleroderma autoantigen... 36 1.9 B

  8. 26 CFR 601.203 - Offers in compromise.

    Science.gov (United States)

    2010-04-01

    ... penalty and the District Counsel concurs in the acceptance of the offer, or (iv) Recommend to the Regional Commissioner the acceptance of the offer if it involves a civil liability of $100,000 or over. (2)(i) If the... acceptance or rejection of the offer together with the examining officer's report of the investigation....

  9. Effect of La203 nanoparticles on properties of molybdenum powder

    Institute of Scientific and Technical Information of China (English)

    王金淑; 周美玲; 左铁镛; 聂祚仁; 张久兴; 刘娟

    2001-01-01

    The properties of La2O3-doped molybdenum powder were studied. The La2O3 nanoparticles on the surface of molybdenum powder which is produced by the reduction of La(NO3)3-doped MoO2 in hydrogen decrease the intensity of feature energy loss peak of molybdenum substrate; but increase that of peak of Mo 3d. The surface of molybdenum powder exposed to the atmosphere can be reduced because the surface is mainly covered with La2O3 nanoparticles. As a result, the capability of anti-oxidation of molybdenum is improved.

  10. Dicty_cDB: CHG203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available MXVIXXXMXVMXXXMVVMIXTXVVMIIXMXXMPMMVVXMIXMVMAXMXRDDXXXWW* *xx*wr*xwsr*w*sxxxwxxxx*ww*xxs*w*xxxx*xw*xxsx*w*xxsxwxvxxxxm vxxmakmvvx...avkmvxxikxvvxitktsgxdnxdpwxrxxxwwxkxpr**xxpxc**txs rw* Trans...xrxx ws*xwprwx*xrsrwxxxsrxx*x*prrvvxitxtrgxdxrdggxnxqgdexxrdvdexx qdg Frame B: *q...kikiwkkmlkn skkl*npsrkmi*fiilnmlmktq*krikkng--- ---dggdnxxxxgdgxxdggddxhxgghdnhxaxdahdggdxdxdgdgxxdx**xx*xvv mxxxmavxmvxmmvimxxmvx...xxxmvvxtxmmvxxxxxxvvxxxxivvxmxxmvgdxgxd gxxxgqdgxxxgqdgxxxq

  11. 49 CFR 219.203 - Responsibilities of railroads and employees.

    Science.gov (United States)

    2010-10-01

    ... involved in the accident or incident. In any case where an operator, dispatcher, signal maintainer or other... duty tour. An employee who has been transported to receive medical care is not released from duty...

  12. 22 CFR 203.6 - IPVO conditions of registration.

    Science.gov (United States)

    2010-04-01

    ... members. (f) Condition No. 6 (Financial Viability). That it: (1) Accounts for its funds in accordance with generally accepted accounting principles (GAAP) or generally accepted accounting standards of IPVO's country of domicile. (2) Has a sound financial position; (3) Provides its financial statements to the...

  13. 7 CFR 62.203 - How to withdraw service.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) LIVESTOCK, MEAT, AND OTHER AGRICULTURAL COMMODITIES (QUALITY SYSTEMS VERIFICATION PROGRAMS) Quality Systems Verification...

  14. 24 CFR 984.203 - FSS family selection procedures.

    Science.gov (United States)

    2010-04-01

    ... Action Plan. (c) Motivation as a selection factor—(1) General. a PHA may screen families for interest, and motivation to participate in the FSS program, provided that the factors utilized by the PHA are those which solely measure the family's interest, and motivation to participate in the FSS program....

  15. 14 CFR 1274.203 - Solicitations/cooperative agreement notices.

    Science.gov (United States)

    2010-01-01

    ..., occupational health, security (including information technology security), environmental, export control, and... CAN shall notify potential recipients of the relative importance of factors, and any subfactors or... with its proposal stating “How” the recipient will accomplish the task(s). Depending on its...

  16. 29 CFR 541.203 - Administrative exemption examples.

    Science.gov (United States)

    2010-07-01

    ... real estate transaction or a collective bargaining agreement, or designing and implementing productivity improvements) generally meets the duties requirements for the administrative exemption, even if... or safety, building or construction, health or sanitation, environmental or soils specialists...

  17. 47 CFR 25.203 - Choice of sites and frequencies.

    Science.gov (United States)

    2010-10-01

    ... strength (mV/m) Power flux density 1 (dBW/m2) Below 540 kHz 10 −65.8 540 to 1600 kHz 20 −59.8 1.6 to 470... shall conform to the power flux density limits at the earth's surface specified in appropriate parts of... data which indicates whether the field strength or power flux density figures in the above table...

  18. 49 CFR 1540.203 - Security threat assessment.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION SECURITY CIVIL AVIATION SECURITY: GENERAL RULES... Transportation Worker Identification Credential or Hazardous Materials Endorsement programs. (3) A...

  19. 48 CFR 852.203-70 - Commercial advertising.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Commercial advertising... Commercial advertising. As prescribed in 803.570-2, insert the following clause: Commercial Advertising (JAN... solicitation, he/she will not advertise the award of the contract in his/her commercial advertising in such...

  20. 15 CFR 971.203 - Commercial recovery plan.

    Science.gov (United States)

    2010-01-01

    ... ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR COMMERCIAL RECOVERY PERMITS Applications Contents... requirements for resource assessment and logical mining unit (§ 971.501); (6) A description of the methods and... identification of any toxic substances in wastes....

  1. Central Asian Leadership Succession: When, Not If. Number 203

    Science.gov (United States)

    2003-12-01

    R E C T O R AT E Robert A. Silano Director of Publications The Institute for National Strategic Studies publishes books, monographs, and reports on...Government. P U B L I C AT I O N D I R E C T O R AT E Robert A. Silano Director of Publications The Institute for National Strategic Studies...R AT E Robert A. Silano Director of Publications The Institute for National Strategic Studies publishes books, monographs, and reports on national

  2. 23 CFR 500.203 - TMS general requirements.

    Science.gov (United States)

    2010-04-01

    ... inspection and copying as prescribed in 49 CFR part 7, appendix D. (c) The TMS shall cover all public roads.... Available for inspection as prescribed in 49 CFR part 7, appendix D. 5 Traffic Monitoring Guide, DOT/FHWA, publication No. FHWA-PL-95-031, February 1995. Available for inspection and copying as prescribed in 49...

  3. {sup 203,205}Tl NMR Studies of Crystallographically Characterized Thallium Alkoxides. X-Ray Structures of [Tl(OCH{sub 2}CH{sub 3})]4 and [Tl(OAr)]{sub infinity} where OAr = OC{sub 6}H{sub 3}(Me){sub 2}-2,6 and OC{sub 6}H{sub 3}(Pr{sup i}){sub 2}-2,6

    Energy Technology Data Exchange (ETDEWEB)

    ZECHMANN,CECILIA A.; BOYLE,TIMOTHY J.; PEDROTTY,DAWN M.; ALAM,TODD M.; LANG,DAVID P.; SCOTT,BRIAN L.

    2000-07-25

    [Tl(OCH{sub 2}CH{sub 3})]{sub 4}, (1) was reacted with excess HOR to prepare a series of [Tl(OR)]{sub n} where OR= OCHMe{sub 2} (2, n = 4), OCMe{sub 3} (3, n = 4), OCH{sub 2}CMe{sub 3} (4, n = 4), OC{sub 6}H{sub 3}(Me){sub 2}-2,6 (5, n = {infinity}), and OC{sub 6}H{sub 3}(Pr{sup i}){sub 2}-2,6 (6, n = {infinity}). Single crystal X-ray diffraction was used to determine the structure of compounds ligated by more sterically demanding ligands. Compound 4 was found to adopt a cubane structure, while 5 and 6 formed linear polymeric structures. These compounds were additionally characterized by {sup 203,205}Tl solution and {sup 205}Tl solid state NMR. Compounds 1--4 were found to remain intact in solution while the polymeric species, 5 and 6, appeared to be fluxional. While variations in the solution and solid state structures for the tetrameric [Tl(OR)]{sub 4} and polymeric [Tl(OAr)]{sub {infinity}} may be influenced by the steric hindrance of their respective ligands, the covalency of the species is believed to be more an effect of the parent alcohol acidity.

  4. 10 CFR Appendix C to Part 20 - Quantities 1 of Licensed Material Requiring Labeling

    Science.gov (United States)

    2010-01-01

    ... Polonium-205 1,000 Polonium-207 1,000 Polonium-210 0.1 Astatine-207 100 Astatine-211 10 Radon-220 1 Radon-222 1 Francium-222 100 Francium-223 100 Radium-223 0.1 Radium-224 0.1 Radium-225 0.1 Radium-226...

  5. 30 CFR 203.78 - Do I keep relief approved by MMS under §§ 203.60-203.77 for my lease, unit or project if prices...

    Science.gov (United States)

    2010-07-01

    ... base oil price threshold set under paragraph (a) is $28.00 per barrel, and the daily closing NYMEX light sweet crude oil prices for the previous calendar year exceeds $28.00 per barrel, as adjusted in... daily closing NYMEX light sweet crude oil prices for the previous calendar year exceeds $3.50...

  6. 48 CFR 52.203-12 - Limitation on Payments to Influence Certain Federal Transactions.

    Science.gov (United States)

    2010-10-01

    ..., with the intent to influence, any communication to or appearance before an officer or employee of any... individual, corporation, company, association, authority, firm, partnership, society, State, and local... communications and services expressly authorized by paragraphs (c)(1) and (2) of this clause are permitted....

  7. 13 CFR 106.203 - What provisions must be set forth in a Cosponsorship Agreement?

    Science.gov (United States)

    2010-01-01

    ... the Cosponsored Activity; (d) A proposed budget demonstrating: (1) The type and source of financial contribution(s) (including but not limited to cash, in-kind, Gifts, and Participant Fees) that the SBA and each... budget and will be liquidated prior to other sources of funding for the Cosponsored Activity....

  8. Preparation of Carbon Nanotubes by the Catalysis of Polymer Metal Complex on Porous Al203 Matrix

    Institute of Scientific and Technical Information of China (English)

    SHI YanLi; ZHANG XiaoGang; LI HuLin

    2001-01-01

    @@ At present, synthesis of carbon nanotubes (CNTs) is normally conducted on a vapor-to-solid interface at ca. 500-3500℃ via various vapor phase methods, such as are discharge, laser ablation, catalytic pyrolysis and chemical vapor deposition, etc.1-2 Recently, channel materials (such as channels of alumina and of AlPO4-5 zeolite) 3 have been utilized as solid-state templates to grow CNTs inside the channel. Here we described a novel method to prepare the carbon nanotubes based on the decomposition of C2H2 gas on the Co-Ni catalyst anchored by polymer complex on the porous A12O3 matrix. The degree of graphitization of synthesized CNTs and catalysts are of great interest.

  9. Preparation of Carbon Nanotubes by the Catalysis of Polymer Metal Complex on Porous Al203 Matrix

    Institute of Scientific and Technical Information of China (English)

    SHI; YanLi

    2001-01-01

    At present, synthesis of carbon nanotubes (CNTs) is normally conducted on a vapor-to-solid interface at ca. 500-3500℃ via various vapor phase methods, such as are discharge, laser ablation, catalytic pyrolysis and chemical vapor deposition, etc.1-2 Recently, channel materials (such as channels of alumina and of AlPO4-5 zeolite) 3 have been utilized as solid-state templates to grow CNTs inside the channel. Here we described a novel method to prepare the carbon nanotubes based on the decomposition of C2H2 gas on the Co-Ni catalyst anchored by polymer complex on the porous A12O3 matrix. The degree of graphitization of synthesized CNTs and catalysts are of great interest.  ……

  10. 34 CFR 403.203 - What are the State's responsibilities for a State assessment?

    Science.gov (United States)

    2010-07-01

    ... programs to meet the needs of individuals who are members of special populations. (12) Other factors... disseminate those criteria. (d) Assessment criteria must include at least the following factors, but may... technological setting. (f)(1) Each State board shall complete the initial assessment required by paragraph...

  11. In-situ RHEED analysis of atomic layer deposition and characterization of AL203 gate dielectrics

    NARCIS (Netherlands)

    Bankras, R.G.; Aarnink, A.A.I.; Holleman, J.; Schmitz, J.

    2003-01-01

    A new custom designed reactor was realized at the MESA+ cleanroom to fabricate high-k dielectrics using atomic layer deposition (ALD). Key features of the reactor are: a small reactor volume, in-situ RHEED analysis and low background pressure. The effect of precursor and purge pulse times is discuss

  12. Yeast Interacting Proteins Database: YJR091C, YDR203W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpre...As encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexp

  13. The Future of Architecture Collaborative Information Sharing: DoDAF Version 2.03 Updates

    Science.gov (United States)

    2012-04-30

    Salamander x Select Solution Factory Select Business Solutions BPMN , UML x SimonTool Simon Labs x SimProcess CACI BPMN x System Architecture Management...for DoDAF Mega UML x Metastorm ProVision Metastorm BPMN x Naval Simulation System - 4 Aces METRON x NetViz CA x OPNET OPNET x Tool Name Vendor Primary

  14. 7 CFR 1901.203 - Title VIII of the Civil Rights Act of 1968.

    Science.gov (United States)

    2010-01-01

    ..., rental, or financing of housing contained in title VIII apply to: (1) All dwellings financed by loans... equal housing opportunity throughout the nation. We encourage and support an affirmative advertising and... Public Law 103-354 programs and referral to the Department of Justice for suit by the United States...

  15. CALiPER Report 20.3: Robustness of LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-12-30

    A small sample of each of the CALiPER Application Summary Report 20 PAR38 lamp types underwent stress testing that included substantial temperature and humidity changes, electrical variation, and vibration. The results do not directly address expected lifetime, but can be compared with one another, as well as with benchmark conventional products, to assess the relative robustness of the product designs.

  16. CALiPER Report 20.3: Robustness of LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    Poplawski, Michael E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Royer, Michael P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Brown, Charles C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-12-01

    Three samples of 40 of the Series 20 PAR38 lamps underwent multi-stress testing, whereby samples were subjected to increasing levels of simultaneous thermal, humidity, electrical, and vibrational stress. The results do not explicitly predict expected lifetime or reliability, but they can be compared with one another, as well as with benchmark conventional products, to assess the relative robustness of the product designs. On average, the 32 LED lamp models tested were substantially more robust than the conventional benchmark lamps. As with other performance attributes, however, there was great variability in the robustness and design maturity of the LED lamps. Several LED lamp samples failed within the first one or two levels of the ten-level stress plan, while all three samples of some lamp models completed all ten levels. One potential area of improvement is design maturity, given that more than 25% of the lamp models demonstrated a difference in failure level for the three samples that was greater than or equal to the maximum for the benchmarks. At the same time, the fact that nearly 75% of the lamp models exhibited better design maturity than the benchmarks is noteworthy, given the relative stage of development for the technology.

  17. 5 CFR 330.203 - Eligibility due to reduction in force.

    Science.gov (United States)

    2010-01-01

    ... does not lose RPL eligibility. (v) Declines an interview or fails to appear for a scheduled interview... individual from the RPL because of failure to reply to a specific permanent job offer or an inquiry of... effect on RPL eligibility or continuation of RPL consideration. (f) Consideration for all jobs...

  18. 24 CFR 203.462 - Pro rata payment of premium before termination.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Pro rata payment of premium before... Pro rata payment of premium before termination. No contract of insurance shall be terminated until the lender has paid to the Commissioner the pro rata portion of the current annual insurance premium....

  19. 12 CFR 308.203 - Order to dismiss a director or senior executive officer.

    Science.gov (United States)

    2010-01-01

    ... executive officer under § 38(f)(2)(F)(ii) of the FDI Act, the FDIC shall also serve a copy of the directive... the bank based on supervisory criteria other than capital, pursuant to section 38(g) of the FDI...

  20. CALiPER Report 20.3: Robustness of LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    Poplawski, Michael E.; Royer, Michael P.; Brown, Charles C.

    2014-12-31

    Three samples of 40 of the Series 20 PAR38 lamps underwent multi-stress testing, whereby samples were subjected to increasing levels of simultaneous thermal, humidity, electrical, and vibrational stress. The results do not explicitly predict expected lifetime or reliability, but they can be compared with one another, as well as with benchmark conventional products, to assess the relative robustness of the product designs. On average, the 32 LED lamp models tested were substantially more robust than the conventional benchmark lamps. As with other performance attributes, however, there was great variability in the robustness and design maturity of the LED lamps. Several LED lamp samples failed within the first one or two levels of the ten-level stress plan, while all three samples of some lamp models completed all ten levels. One potential area of improvement is design maturity, given that more than 25% of the lamp models demonstrated a difference in failure level for the three samples that was greater than or equal to the maximum for the benchmarks. At the same time, the fact that nearly 75% of the lamp models exhibited better design maturity than the benchmarks is noteworthy, given the relative stage of development for the technology.

  1. 21 CFR 203.60 - Request and receipt forms, reports, and records.

    Science.gov (United States)

    2010-04-01

    ... SERVICES (CONTINUED) DRUGS: GENERAL PRESCRIPTION DRUG MARKETING Request and Receipt Forms, Reports, and... of review, analysis, verification, authentication, and reproduction by the person who executed the... available within 2 business days of a request....

  2. 203 SINGLE-STEP GENE EDITING OF 3 XENOANTIGENS IN PORCINE FIBROBLASTS USING PROGRAMMABLE NUCLEASES.

    Science.gov (United States)

    Perota, A; Lagutina, I; Quadalti, C; Duchi, R; Turini, P; Crotti, G; Colleoni, S; Conchon, S; Concordet, J-P; Lazzari, G; Soulillou, J-P; Galli, C

    2016-01-01

    Programmable nucleases (ZFN, Tal Effector Nucleases, and CRISPR) opened a new era for mammal genome editing, in particular for the pigs used for xenotransplantation. Multiple gene editing events are required both for knockout (KO) of xenoantigens and for targeted integration of human protective genes (Perota et al. 2016 J. Genet. Genomics 43, 233-23). The objective of the present work was to edit selected pig lines to KO the enzymes coding for the most relevant xenoantigens (i.e. GGTA1, CMAH, and B4GalNT2), combining Talens and CRISPR/Cas9 technologies to magnetic beads selection (Li et al. 2013 Xenotransplantation 22, 20-31). Primary porcine adult fibroblasts were transfected using Nucleofector (V-024 program). In a single reaction 2×10(6) fibroblasts were co-transfected using 2 different sets of TALENS (4μg/set) specific for CMAH (Conchon et al., 2013) and GGTA1 (Perota et al., 2015) genes together with B4GalNT2-specific CRISPR/Cas9 expression vector (2μg; pX330-B4GalNT2; Estrada et al., 2015). Eight days post-transfection (DPT), Gal-/- cells were selected initially using biotin-conjugated IB4 lectin (Sigma, St. Louis, MO, USA) and magnetic beads (Dynabeads M-280, Thermo Fisher Scientific, Waltham, MA, USA). The selected cells were then plated on 150-mm Petri dishes (200 cells/dish) and cultured for 10 days. Selected colonies were expanded for PCR analysis and cryopreserved for somatic cell nuclear transfer (SCNT). All colonies were analysed by PCR for CMAH gene and their resulting products were digested with HindIII (HindIII-RFLP). Colonies that lost wild-type HindIII as a consequence of Talens effected deletion were PCR characterised for GGTA1, selecting those that had detectable Indels after gel electrophoresis and finally analysed by PCR for B4GalNT2. All PCR products were validated by sequencing for all the 3 genes of interest (TopoTA, Thermo Fisher Scientific). Selected colonies were used as nuclear donors for SCNT (Lagutina et al., 2006). Eight DPT we obtained 3.45×10(6) cells. About 6.0×10(3) Gal-negative cells (0.17%) were collected from the supernatant after magnetic beads separation. Eighteen DPT, 120 colonies were picked up and their HindIII-RFLP analyses on CMAH gene revealed that 22 colonies (18.3%) were KO for both CMAH alleles. Of these 22 colonies following electrophoretic analyses of GGTA1-PCR products, 13 colonies had detectable Indels. These 13 colonies were finally PCR analysed and sequenced for B4GalNT2 and sequenced. Final sequencing results confirmed that 2 colonies (1.6%) resulted in KO for the 3 genes. Three different zona-free SCNT experiments were done and 579 reconstructed embryos were obtained. On Day 7, 322 morulae or blastocysts (56%) were transferred in 3 synchronised sows and 2 (66%) became pregnant. In conclusion, after gene editing with programmable nucleases, combining beads-mediated selection with well-designed molecular analyses, we developed a multistep assay that can be used efficiently to detect desired gene edited events in cell colonies suitable for the SCNT. Embryos generated after SCNT were able to establish pregnancies at a high rate.

  3. 30 CFR 203.89 - What is in a cost report?

    Science.gov (United States)

    2010-07-01

    ... based on historical costs, engineering estimates, or analogous projects. These costs cover: (1... evaluations). (d) Transportation costs, based on historical costs, engineering estimates, or analogous... lines; and (3) Gas plant processing for natural gas liquids. (e) Abandonment costs, based on...

  4. 33 CFR 203.14 - Responsibilities of non-Federal interests.

    Science.gov (United States)

    2010-07-01

    ... during flood situations; (3) Training personnel to operate, maintain, and patrol projects during crisis... Program (RIP), as detailed in subpart D of this part; and, (5) Responsible regulation, management, and use... official. For flood fight direct assistance and Post Flood Response assistance, non-Federal interests...

  5. 46 CFR 27.203 - What are the requirements for fire detection on towing vessels?

    Science.gov (United States)

    2010-10-01

    ... maintaining indication by the visible alarms; (4) A circuit-fault detector test-switch; and (5) Labels for all switches and indicator lights, identifying their functions; (e) The system draws power from two...

  6. 48 CFR 52.203-13 - Contractor Code of Business Ethics and Conduct.

    Science.gov (United States)

    2010-10-01

    ... management or supervisory responsibilities within a business entity (e.g., general manager; plant manager... Schedule, or any other procurement instrument intended for use by multiple agencies, the Contractor shall... the risk of criminal conduct, with appropriate steps to design, implement, or modify the...

  7. Rilem TC 203-RHM: Repair mortars for historic masonry. Requirements for repointing mortars for historic masonry

    NARCIS (Netherlands)

    Hees, R.P.J. van; Groot, C.; Hughes, J.J.; Balen, K. van; Bicer-Simsir, B.; Binda, L.; Elsen, J.; Konow, T. von; Lindqvist, J.E.; Papayanni, I.; Subercaseaux, M.; Tedeschi, C.; Toumbakari, E.E.; Thompson, B.

    2012-01-01

    This paper gives a summary of functional and performance requirements for repointing mortars for historic masonry (design, execution and maintenance). Successful performance of repair and conservation of mortar in historic masonry requires more care with design and execution than with modern masonry

  8. 17 CFR 275.203-1 - Application for investment adviser registration.

    Science.gov (United States)

    2010-04-01

    ..., substantial changes to Part II of Form ADV. Thus, the rules for preparing, delivering, and offering Part II... materially inaccurate. State law may continue to require you to file Part II with the appropriate State...) When filed. Each Form ADV is considered filed with the Commission upon acceptance by the IARD....

  9. 30 CFR 203.73 - How do suspension volumes apply to natural gas?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do suspension volumes apply to natural gas... suspension volumes apply to natural gas? You must measure natural gas production under the royalty-suspension volume as follows: 5.62 thousand cubic feet of natural gas, measured in accordance with 30 CFR part...

  10. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (203b-0613-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  11. 48 CFR 252.203-7000 - Requirements Relating to Compensation of Former DoD Officials.

    Science.gov (United States)

    2010-10-01

    ... TO COMPENSATION OF FORMER DOD OFFICIALS (JAN 2009) (a) Definition. Covered DoD official, as used in... evaluation team for a contract in an amount in excess of $10 million. (b) The Contractor shall not...

  12. 30 CFR 203.5 - What is MMS's authority to collect information?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What is MMS's authority to collect information... to collect information? (a) The Office of Management and Budget (OMB) has approved the information....” (b) The MMS collects this information to make decisions on the economic viability of...

  13. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (203a-0613-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  14. Yeast Interacting Proteins Database: YDL203C, YPL124W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available SPC29 Inner plaque spindle pole body (SPB) component, links the central plaque c...RF YPL124W Prey gene name SPC29 Prey description Inner plaque spindle pole body (SPB) component, links the c

  15. 31 CFR 540.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    .... person holding funds, such as currency, bank deposits, or liquidated financial obligations subject to... account: (i) In a federally-insured U.S. bank, thrift institution, or credit union, provided the funds are... holder of blocked tangible property, such as chattels or real estate, or of other blocked property,...

  16. 31 CFR 594.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... currency, bank deposits, or liquidated financial obligations, subject to § 594.201(a) shall hold or place...-insured U.S. bank, thrift institution, or credit union, provided the funds are earning interest at rates... tangible property, such as chattels or real estate, or of other blocked property, such as debt or...

  17. 31 CFR 544.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... funds, such as currency, bank deposits, or liquidated financial obligations, subject to § 544.201(a...) In a federally-insured U.S. bank, thrift institution, or credit union, provided the funds are earning... affirmative obligation for the holder of blocked tangible property, such as chattels or real estate, or...

  18. 31 CFR 588.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... currency, bank deposits, or liquidated financial obligations subject to § 588.201(a) shall hold or place...-insured U.S. bank, thrift institution, or credit union, provided the funds are earning interest at rates... holder of blocked tangible property, such as chattels or real estate, or of other blocked property,...

  19. 31 CFR 545.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... currency, bank deposits, or liquidated financial obligations, subject to § 545.201(a) shall hold or place...-insured U.S. bank, thrift institution, or credit union, provided the funds are earning interest at rates... tangible property, such as chattels or real estate, or of other blocked property, such as debt or...

  20. 31 CFR 541.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... directed by the Office of Foreign Assets Control, any U.S. person holding funds, such as currency, bank... term blocked interest-bearing account means a blocked account: (i) In a federally-insured U.S. bank... tangible property, such as chattels or real estate, or of other blocked property, such as debt or...

  1. 31 CFR 542.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... directed by the Office of Foreign Assets Control, any U.S. person holding funds, such as currency, bank... term blocked interest-bearing account means a blocked account: (i) In a federally-insured U.S. bank... tangible property, such as chattels or real estate, or of other blocked property, such as debt or...

  2. 31 CFR 586.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... U.S. person holding funds, such as currency, bank deposits, or liquidated financial obligations... blocked account: (i) In a federally-insured U.S. bank, thrift institution, or credit union, provided the... affirmative obligation for the holder of blocked tangible property, such as chattels or real estate, or...

  3. 31 CFR 543.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... currency, bank deposits, or liquidated financial obligations, subject to § 543.201(a) shall hold or place...-insured U.S. bank, thrift institution, or credit union, provided the funds are earning interest at rates... holder of blocked tangible property, such as chattels or real estate, or of other blocked property,...

  4. 31 CFR 547.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ..., such as currency, bank deposits, or liquidated financial obligations, subject to § 547.201(a) shall... federally-insured U.S. bank, thrift institution, or credit union, provided the funds are earning interest at... affirmative obligation for the holder of blocked tangible property, such as chattels or real estate, or...

  5. 31 CFR 546.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... directed by the Office of Foreign Assets Control, any U.S. person holding funds, such as currency, bank... term blocked interest-bearing account means a blocked account: (i) In a federally-insured U.S. bank... tangible property, such as chattels or real estate, or of other blocked property, such as debt or...

  6. 31 CFR 548.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... directed by the Office of Foreign Assets Control, any U.S. person holding funds, such as currency, bank... term blocked interest-bearing account means a blocked account: (i) In a federally-insured U.S. bank... tangible property, such as chattels or real estate, or of other blocked property, such as debt or...

  7. 31 CFR 587.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... Control, any U.S. person holding funds, such as currency, bank deposits, or liquidated financial... account means a blocked account: (i) In a federally-insured U.S. bank, thrift institution, or credit union... affirmative obligation for the holder of blocked tangible property, such as chattels or real estate, or...

  8. 30 CFR 285.203 - With whom will MMS consult before issuance of a lease?

    Science.gov (United States)

    2010-07-01

    ... other relevant Federal laws. Federal statutes that require us to consult with or respond to findings... process, MMS prior to issuing the lease, will coordinate and consult with relevant Federal...

  9. 41 CFR 105-54.203-3 - Submission to Library of Congress.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Submission to Library of... Submission to Library of Congress. The GSA Committee Management Officer furnishes a copy of each charter to the Library of Congress when or shortly after copies are filed with the requisite committees of...

  10. 5 CFR 831.203 - Continuation of coverage for employees of the Metropolitan Washington Airports Authority.

    Science.gov (United States)

    2010-01-01

    ... Service Retirement System. (e) Sick leave. An employee who retires, or dies leaving a survivor entitled to... is under a formal leave system as defined in § 831.302. ... OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT...

  11. Rilem TC 203-RHM: repair mortars for historic masonry. Performance requirements for renders and plasters

    NARCIS (Netherlands)

    Hees, R.P.J. van; Hughes, J.J.; Balen, K. van; Bicer-Simsir, B.; Binda, L.; Elsen, J.; Konow, T. von; Lindqvist, J.E.; Maurenbrecher, P.; Papayanni, I.; Subercaseaux, M.; Tedeschi, C.; Toumbakari, E.E.; Thompson, M.

    2012-01-01

    This article focuses on repair or replacement mortars for historical buildings. Both the decision process and questions arising are dealt with, in order to better define and illustrate technical requirements for mortars to be used for the repair or restoration of monuments and historic buildings (ma

  12. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (203-0609-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  13. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (203a-0613-272217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  14. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (203c-0613-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  15. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (203c-0613-272217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  16. 9 CFR 93.203 - Ports designated for the importation of poultry.

    Science.gov (United States)

    2010-01-01

    ... PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND POULTRY..., Vermont; Oroville and Sumas, Washington. (c) Mexican border ports. The following land border ports...

  17. 76 FR 63602 - Voting Rights Act Amendments of 2006, Determinations Under Section 203

    Science.gov (United States)

    2011-10-13

    ... County Hispanic. Grant County Hispanic. Guadalupe County Hispanic. Harding County Hispanic. Hidalgo...). Rio Arriba County Hispanic. San Juan County American Indian (Navajo). San Miguel County Hispanic... (Vietnamese). Hidalgo County Hispanic. Hockley County Hispanic. Hudspeth County Hispanic. Jim Hogg...

  18. Substitute potting compounds for Sylgard 93-120. Process Development Endeavor Nos. 203 and 207

    Energy Technology Data Exchange (ETDEWEB)

    Flowers, G.L.; Switzer, S.T.

    1979-07-01

    The report deals with the development of substitute potting compounds to replace the no longer available Dow Corning 93-120. Three different approaches to formulate a substitute, two of which were successful are presented. The efforts discussed are a part of a laarger project to better understand the silicone potting compound technology and to formulate substitutes for specific materials which have been discontinued by Dow Corning.

  19. 75 FR 2925 - Sixteenth Plenary Meeting: RTCA Special Committee 203: Unmanned Aircraft Systems

    Science.gov (United States)

    2010-01-19

    ... Closing Session Attendance is open to the interested public but limited to space availability. With the...: Unmanned Aircraft Systems. SUMMARY: The FAA is issuing this notice to advise the public of a meeting of... FAA Status Reports Special Committee Status Overview Requirements & Architecture Product Team...

  20. 76 FR 24957 - Nineteenth Meeting: RTCA Special Committee 203: Unmanned Aircraft Systems

    Science.gov (United States)

    2011-05-03

    ... interested public but limited to space availability. With the approval of the chairman, members of the public...: Unmanned Aircraft Systems. SUMMARY: The FAA is issuing this notice to advise the public of a meeting of... Workgroup Sense and Avoid Workgroup Ad Hoc Group Report Architecture Group Report Modeling and...