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Sample records for astatine 203

  1. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  2. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  3. Adsorption interaction of astatine species with quartz and gold surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Serov, A. [Paul Scherrer Institute, Villigen (Switzerland). Lab. for Radiochemistry and Environmental Chemistry; Bern Univ. (Switzerland). Dept. for Chemistry and Biochemistry; Aksenov, N.; Bozhikov, G. [Joint Institute for Nuclear Research, Dubna (RU). Flerov Lab. of Nuclear Reactions] (and others)

    2011-07-01

    The adsorption interaction of various astatine species with quartz and gold surfaces was investigated by gas chromatography methods. Due to variations of the redox potential of the carrier gas elemental astatine, astatine oxide and hypo-astatic acid have been produced. The identification of the astatine compounds is based on the analogy assumption to the gas phase chemistry of the closest homologues in group 17 of the periodic table, iodine and bromine. The deposition temperatures as well as enthalpies of adsorption have been determined for the astatine species. The enhancement of the metallic character within group 17 towards higher Z is clearly confirmed. Macroscopic properties (sublimation enthalpy) of previously unstudied AtO{sub 2} and HAtO were estimated. The determined data for elemental astatine were compared to available literature data. Based on the obtained experimental results possible designs of experiments for studying of chemical properties of the recently discovered element 117 can be suggested. (orig.)

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. Discovery of the astatine, radon, francium, and radium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  6. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  7. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  8. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  9. AED 203 Courses Tutorial / indigohelp

    OpenAIRE

    hela

    2015-01-01

    AED 203 Assignment: Science Experiment AED 203 Capstone Discussion Question AED 203 Final Project: Effective Classroom Management Plan AED 203 WEEK 1 ONE DISCUSSION 1 AED 203 WEEK 1 ONE DISCUSSION 2 AED 203 CheckPoint: Room Plan AED 203 CheckPoint: Effective Lesson Plan AED 203 WEEK 3 THREE DISCUSSION 1 AED 203 WEEK 3 THREE DISCUSSION 2 AED 203 CheckPoint: Monitoring Student Progress AED 203 WEEK 5 FIVE DISCUSSION QUESTION 1 AED 203 WEEK 5 FIVE DISC...

  10. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  11. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  12. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom;

    2015-01-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...... and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting...... vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method...

  13. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  14. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  15. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  16. ECO 203 NEW Tutorial / Uoptutorial

    OpenAIRE

    Meri

    2015-01-01

    For more course tutorials visit www.uoptutorial.com     ECO 203 Week 1 Question ECO 203 Week 1 DQ 1 Economics Systems ECO 203 Week 1 DQ 2 Role of Government ECO 203 Week 2 Journal Challenges to the American Labor Force ECO 203 Week 2 DQ 1 The Current State of the Economy and Unemployment  ECO 203 Week 2 DQ 2 Who Benefits and Who Loses from Inflation? ECO 203 Week 3 Assignment Efforts to Reduce the Budget Deficit ECO 203 Week 3 Discuss...

  17. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  18. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  19. SOC 203 ASH Tutorial course/ Uoptutorial

    OpenAIRE

    Michael Crichton

    2015-01-01

    For more course tutorials visit www.uoptutorial.com   SOC 203 Week 1 DQ 1 The Sociological Imagination SOC 203 Week 1 DQ 2 Homelessness SOC 203 Week 2 DQ 1 Education and Equality SOC 203 Week 2 DQ 2 Title IX SOC 203 Week 2 Final Paper Preparation SOC 203 Week 3 DQ 1 Hate Crimes SOC 203 Week 3 DQ 2 Prisons and the War on Drugs SOC 203 Week 3 The Interconnection of Social Problems SOC 203 Week 4 DQ 1 Gay Parenting SOC 203 Week 4 DQ 2 Reinvent...

  20. ECO 203 ASH course tutorial/tutorialoutlet

    OpenAIRE

    NARESH 34

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com   ECO 203 Week 1 DQ 1 Economics Systems ECO 203 Week 1 DQ 2 Role of Government ECO 203 Week 1 Quiz ECO 203 Week 2 DQ 1 The Current State of the Economy and Unemployment ECO 203 Week 2 DQ 2 Who Benefits and Who Loses from Inflation ? ECO 203 Week 2 Quiz ECO 203 Week 3 DQ 1 Government Fiscal Policy ECO 203 Week 3 DQ 2 Budget Deficits and the National Debt ECO 203 Week 3 Assignment Efforts to Reduce t...

  1. SOC 203 ASH Course Tutorial/Tutorialrank

    OpenAIRE

    graceruby

    2015-01-01

    For more course tutorials visit   www.tutorialrank.com Tutorial Purchased: 5 Times, Rating: A+   SOC 203 Week 1 DQ 1 The Sociological Imagination SOC 203 Week 1 DQ 2 Homelessness SOC 203 Week 2 DQ 1 Education and Equality SOC 203 Week 2 DQ 2 Title IX SOC 203 Week 2 Final Paper Preparation SOC 203 Week 3 DQ 1 Hate Crimes SOC 203 Week 3 DQ 2 Prisons and the War on Drugs SOC 203 Week 3 The Interconnection of Social Problems SOC 203 We...

  2. 24 CFR 203.203 - Issuance and nature of insured 10-year protection plans.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Issuance and nature of insured 10-year protection plans. 203.203 Section 203.203 Housing and Urban Development Regulations Relating to... Underwriting Procedures Insured Ten-Year Protection Plans (plan) § 203.203 Issuance and nature of insured...

  3. AED 203 uop course tutorial/uop help

    OpenAIRE

    johnson

    2015-01-01

    For more course tutorials visit www.uophelp.com     AED 203 Assignment: Science Experiment AED 203 Capstone Discussion Question AED 203 Final Project: Effective Classroom Management Plan AED 203 WEEK 1 ONE DISCUSSION 1 AED 203 WEEK 1 ONE DISCUSSION 2 AED 203 CheckPoint: Room Plan AED 203 CheckPoint: Effective Lesson Plan AED 203 WEEK 3 THREE DISCUSSION 1 AED 203 WEEK 3 THREE DISCUSSION 2 AED 203 CheckPoint: Monitoring Student Progr...

  4. AED 203 UOP Course Tutorial/TutorialRank

    OpenAIRE

    markenz

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 5 Times, Rating: A+ AED 203 Assignment: Science Experiment AED 203 Capstone Discussion Question AED 203 Final Project: Effective Classroom Management Plan AED 203 WEEK 1 ONE DISCUSSION 1 AED 203 WEEK 1 ONE DISCUSSION 2 AED 203 CheckPoint: Room Plan AED 203 CheckPoint: Effective Lesson Plan AED 203 WEEK 3 THREE DISCUSSION 1 AED 203 WEEK 3 THREE DISCUSSION 2 AED 203 CheckPoint: Monitori...

  5. 24 CFR 203.443 - Insurance premium.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Insurance premium. 203.443 Section 203.443 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... premium. All of the provisions of §§ 203.260 through 203.269 1 concerning mortgage insurance...

  6. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  7. 40 CFR 240.203 - General design.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false General design. 240.203 Section 240.203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR... design....

  8. 5 CFR 850.203 - Other elections.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Other elections. 850.203 Section 850.203...) RETIREMENT SYSTEMS MODERNIZATION Applications for Benefits; Elections § 850.203 Other elections. (a) Any other election may be effected in such form as the Director prescribes under § 850.104. Such...

  9. 46 CFR 109.203 - Sanitation.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Sanitation. 109.203 Section 109.203 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS OPERATIONS Tests, Drills, and Inspections § 109.203 Sanitation. (a) The master or person in charge shall insure that the...

  10. 49 CFR 37.203 - Lift maintenance.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Lift maintenance. 37.203 Section 37.203... DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.203 Lift maintenance. (a) The entity shall establish a system of regular and frequent maintenance checks of lifts sufficient to determine if they are...

  11. 24 CFR 203.7 - Commitment process.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Commitment process. 203.7 Section 203.7 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Insurance, and Commitments § 203.7 Commitment process. For single family mortgage programs that are...

  12. 48 CFR 203.1004 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct 203.1004 Contract clauses. (a) Use the clause at 252.203-7003 in solicitations and contracts that include the FAR clause 52.203-13, Contractor Code of Business Ethics and...

  13. 14 CFR 25.203 - Stall characteristics.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Stall characteristics. 25.203 Section 25.203 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Stalls § 25.203 Stall characteristics. (a) It...

  14. 40 CFR 240.203-1 - Requirement.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirement. 240.203-1 Section 240.203-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.203-1...

  15. 5 CFR 302.203 - Disqualifying factors.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Disqualifying factors. 302.203 Section 302.203 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT IN THE EXCEPTED SERVICE Eligibility Standards § 302.203 Disqualifying factors. (a) The...

  16. 49 CFR 215.203 - Restricted cars.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Restricted cars. 215.203 Section 215.203..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.203 Restricted cars. (a) This section restricts the operation of any railroad freight car that is— (1) More than...

  17. 47 CFR 97.203 - Beacon station.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Beacon station. 97.203 Section 97.203... SERVICE Special Operations § 97.203 Beacon station. (a) Any amateur station licensed to a holder of a Technician, Technician Plus, General, Advanced or Amateur Extra Class operator license may be a beacon....

  18. 30 CFR 75.203 - Mining methods.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Mining methods. 75.203 Section 75.203 Mineral... SAFETY STANDARDS-UNDERGROUND COAL MINES Roof Support § 75.203 Mining methods. (a) The method of mining... faulty pillar recovery methods. Pillar dimensions shall be compatible with effective control of the...

  19. 12 CFR 203.3 - Exempt institutions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Exempt institutions. 203.3 Section 203.3 Banks... DISCLOSURE (REGULATION C) § 203.3 Exempt institutions. (a) Exemption based on state law. (1) A state-chartered or state-licensed financial institution is exempt from the requirements of this regulation if...

  20. 32 CFR 203.13 - Procurement.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Procurement. 203.13 Section 203.13 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS TECHNICAL ASSISTANCE FOR PUBLIC PARTICIPATION (TAPP) IN DEFENSE ENVIRONMENTAL RESTORATION ACTIVITIES § 203.13 Procurement. Procurements will...

  1. 48 CFR 16.203-1 - Description.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Description. 16.203-1 Section 16.203-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Fixed-Price Contracts 16.203-1 Description. (a) A...

  2. 48 CFR 5416.203-1 - Description.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Description. 5416.203-1 Section 5416.203-1 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF DEFENSE TYPES OF CONTRACTS Fixed Price Contracts 5416.203-1 Description. (a)(S-90) Adjustments based...

  3. 46 CFR 169.203 - Description.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Description. 169.203 Section 169.203 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Inspection and Certification Certificate of Inspection § 169.203 Description. The certificate of...

  4. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  5. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  6. Dicty_cDB: AFG203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AF (Link to library) AFG203 (Link to dictyBase) - - - Contig-U16382-1 AFG203E (Link to Original site) AFG20...3F 611 AFG203Z 741 AFG203P 1352 AFG203E 1195 Show AFG203 Library AF (Link to library) Clone ID AFG20...ginal site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/AF/AFG2-A/AFG203Q.Seq.d/ Re...presentative seq. ID AFG203E (Link to Original site) Representative DNA sequence >AFG203 (AFG203Q) /CSM/AF/AFG2-A/AFG20...SM-cDNA Score E Sequences producing significant alignments: (bits) Value AFG203 (AFG203Q) /CSM/AF/AFG2-A/AFG20

  7. SOC 203 uop course tutorial/tutorial rank

    OpenAIRE

    hiolnv

    2015-01-01

    For more course tutorials visit   www.tutorialrank.com Tutorial Purchased: 5 Times, Rating: A+   SOC 203 Week 1 DQ 1 The Sociological Imagination SOC 203 Week 1 DQ 2 Homelessness SOC 203 Week 2 DQ 1 Education and Equality SOC 203 Week 2 DQ 2 Title IX SOC 203 Week 2 Final Paper Preparation SOC 203 Week 3 DQ 1 Hate Crimes SOC 203 Week 3 DQ 2 Prisons and the War on Drugs SOC 203 Week 3 The Interconnection of Social Problems SOC 203 We...

  8. 48 CFR 203.1003 - Requirements.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contractor Code of Business Ethics and Conduct 203.1003 Requirements. (b) Notification of possible contractor violation....

  9. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  10. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  11. 23 CFR 230.203 - Policy.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Policy. 230.203 Section 230.203 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS EXTERNAL PROGRAMS Supportive Services for Minority... participation of minority business enterprises in Federal-aid highway contracts in part through the...

  12. 41 CFR 50-203.18 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Evidence. 50-203.18...-Healey Public Contracts Act § 50-203.18 Evidence. (a) Witnesses appearing at the hearing need not be... shall be tendered in quadruplicate. When evidence is embraced in a document containing matter...

  13. 48 CFR 570.203-2 - Competition.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Competition. 570.203-2... 570.203-2 Competition. (a) Solicit at least three sources to promote competition to the maximum extent..., document the file to explain the lack of competition....

  14. 41 CFR 50-203.11 - Review.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Review. 50-203.11 Section...-Healey Public Contracts Act § 50-203.11 Review. (a) Within twenty (20) days after service of the decision... administrative law judge an original and four copies of a petition for review of the decision. The petition...

  15. 5 CFR 250.203 - Agency responsibilities.

    Science.gov (United States)

    2010-01-01

    ... 250.203 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Strategic Human Capital Management § 250.203 Agency responsibilities. (a) To assist in the assessment of the management of human capital in the Federal Government, and to help meet...

  16. 32 CFR 203.19 - Appeals process.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Appeals process. 203.19 Section 203.19 National....19 Appeals process. DoD Components will establish an appeals process to settle potential disputes... process. The Department of Defense recognizes that the RAB/TRC may disagree with the findings of...

  17. 32 CFR 203.5 - TAPP process.

    Science.gov (United States)

    2010-07-01

    ... to follow the rules and regulations for purchase orders as outlined in the FAR (48 CFR part 13). As a... 32 National Defense 2 2010-07-01 2010-07-01 false TAPP process. 203.5 Section 203.5 National... TAPP process. This section provides an overview of the TAPP process. Specific details referred to...

  18. 14 CFR 1212.203 - Disclosures.

    Science.gov (United States)

    2010-01-01

    ... Records § 1212.203 Disclosures. (a) The system manager shall keep a disclosure accounting for each... (2) In accordance with § 1212.203(g) (1) and (2), below. (c) The disclosure accounting required by...) The name and address of the recipient person or Agency. (d) The disclosure accounting shall...

  19. 40 CFR 86.203-94 - Abbreviations.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Abbreviations. 86.203-94 Section 86.203-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... Later Model Year Gasoline-Fueled New Light-Duty Vehicles, New Light-Duty Trucks and New...

  20. 24 CFR 945.203 - Allocation plan.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Allocation plan. 945.203 Section... FAMILIES Application and Approval Procedures § 945.203 Allocation plan. (a) Applicable terminology. (1) As used in this section, the terms “initial allocation plan” refers to the PHA's first submission of...

  1. 48 CFR 2944.203 - Consent limitations.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Consent limitations. 2944.203 Section 2944.203 Federal Acquisition Regulations System DEPARTMENT OF LABOR CONTRACT MANAGEMENT... rationale), signed by the contracting officer, and included in the contract file....

  2. 7 CFR 1260.203 - Confidential treatment.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Confidential treatment. 1260.203 Section 1260.203 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF PROMOTION AND RESEARCH...

  3. 14 CFR 67.203 - Eye.

    Science.gov (United States)

    2010-01-01

    ... separately, with or without corrective lenses. If corrective lenses (spectacles or contact lenses) are... equivalent, at 16 inches in each eye separately, with or without corrective lenses. If age 50 or older, near... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Eye. 67.203 Section 67.203 Aeronautics...

  4. 24 CFR 203.34 - Credit standing.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Credit standing. 203.34 Section 203.34 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued....34 Credit standing. A mortgagor must have a general credit standing satisfactory to the Commissioner....

  5. 22 CFR 203.2 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... information may be accessed in the daily course of conducting business. (e) International Private Voluntary... Voluntary Organization (LPVO) means a non-U.S. based PVO that meets the definition of an International... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Definitions. 203.2 Section 203.2...

  6. 27 CFR 24.203 - Honey wine.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Honey wine. 24.203 Section... THE TREASURY LIQUORS WINE Production of Agricultural Wine § 24.203 Honey wine. (a) Subject to paragraph (b) of this section, a winemaker, in the production of wine from honey, may add the following:...

  7. 5 CFR 844.203 - Supporting documentation.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Supporting documentation. 844.203 Section... § 844.203 Supporting documentation. (a) An individual or agency filing an application for disability... whatever documentation OPM requires in order to determine whether the individual meets the...

  8. 33 CFR 203.62 - Drought assistance.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Drought assistance. 203.62... Supplies: Contaminated Water Sources and Drought Assistance § 203.62 Drought assistance. (a) Authority. The... political subdivisions, within areas determined to be drought-distressed. (b) General policy. (1) It is...

  9. 40 CFR 600.203-77 - Abbreviations.

    Science.gov (United States)

    2010-07-01

    ....203-77 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Fuel Economy Regulations for 1977 and Later Model Year Automobiles-Procedures for Calculating Fuel Economy Values § 600.203-77 Abbreviations....

  10. 41 CFR 50-203.8 - Hearing.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Hearing. 50-203.8 Section 50-203.8 Public Contracts and Property Management Other Provisions Relating to Public Contracts..., examine, and cross-examine witnesses and to introduce into the record documentary or other evidence....

  11. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  12. 48 CFR 828.203 - Acceptability of individual sureties.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acceptability of individual sureties. 828.203 Section 828.203 Federal Acquisition Regulations System DEPARTMENT OF VETERANS... Acceptability of individual sureties....

  13. Dicty_cDB: CHS203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHS203 (Link to dictyBase) - - - Contig-U11332-1 - (Link to Or...iginal site) - - CHS203Z 727 - - - - Show CHS203 Library CH (Link to library) Clone ID CHS203 (Link to dicty...Base) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U11332-1 Original site URL http://dictycdb.b...LSYDILSLLDS HLWLKKPLTISPQFLTMIGPELDPTLPNNPFKEFFNKLGTSSHDSGDNIDFKIPSFFEDN SRRHWGVETELSTGSCPICTLSLAENPESSFLGST...SYDILSLLDS HLWLKKPLTISPQFLTMIGPELDPTLPNNPFKEFFNKLGTSSHDSGDNIDFKIPSFFEDN SRRHWGVETELSTGSCPICTLSLAENPESSFLGSTP

  14. 5 CFR 2601.203 - Conflict of interest analysis.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Conflict of interest analysis. 2601.203 Section 2601.203 Administrative Personnel OFFICE OF GOVERNMENT ETHICS ORGANIZATION AND PROCEDURES... Acceptance of Gifts § 2601.203 Conflict of interest analysis. (a) A gift shall not be solicited or...

  15. 24 CFR 203.37 - Nature of title to realty.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Nature of title to realty. 203.37 Section 203.37 Housing and Urban Development Regulations Relating to Housing and Urban Development... § 203.37 Nature of title to realty. A mortgage, to be eligible for insurance, must be on real...

  16. 48 CFR 1815.203-72 - Risk management.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Risk management. 1815.203-72 Section 1815.203-72 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE... Proposals and Information 1815.203-72 Risk management. In all RFPs and RFOs for supplies or services...

  17. 9 CFR 113.203 - Feline Panleukopenia Vaccine, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ... Virus. 113.203 Section 113.203 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS STANDARD REQUIREMENTS Killed Virus Vaccines § 113.203 Feline Panleukopenia Vaccine, Killed Virus. Feline...

  18. 24 CFR 203.18a - Solar energy system.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Solar energy system. 203.18a... § 203.18a Solar energy system. (a) The dollar limitation provided in § 203.18(a) may be increased by up... to the installation of a solar energy system. (b) Solar energy system is defined as any...

  19. 24 CFR 203.261 - Calculation of periodic MIP.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Calculation of periodic MIP. 203.261 Section 203.261 Housing and Urban Development Regulations Relating to Housing and Urban...-Periodic Payment § 203.261 Calculation of periodic MIP. The amount of any periodic MIP shall be...

  20. 48 CFR 9.203 - QPL's, QML's, and QBL's.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false QPL's, QML's, and QBL's. 9.203 Section 9.203 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS Qualifications Requirements 9.203 QPL's, QML's, and QBL's....

  1. 5 CFR 2610.203 - Documentation of fees and expenses.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Documentation of fees and expenses. 2610.203 Section 2610.203 Administrative Personnel OFFICE OF GOVERNMENT ETHICS ORGANIZATION AND PROCEDURES IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 2610.203...

  2. 31 CFR 203.10 - Electronic payment methods.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Electronic payment methods. 203.10 Section 203.10 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... TAX AND LOAN PROGRAM Electronic Federal Tax Payments § 203.10 Electronic payment methods. (a)...

  3. 31 CFR 203.9 - Scope of the subpart.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Scope of the subpart. 203.9 Section 203.9 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... LOAN PROGRAM Electronic Federal Tax Payments § 203.9 Scope of the subpart. This subpart prescribes...

  4. 31 CFR 203.12 - EFTPS interest assessments.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false EFTPS interest assessments. 203.12 Section 203.12 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... TAX AND LOAN PROGRAM Electronic Federal Tax Payments § 203.12 EFTPS interest assessments....

  5. 31 CFR 203.13 - Appeal and dispute resolution.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Appeal and dispute resolution. 203.13 Section 203.13 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... TAX AND LOAN PROGRAM Electronic Federal Tax Payments § 203.13 Appeal and dispute resolution....

  6. 48 CFR 1336.203 - Government estimate of construction costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Government estimate of construction costs. 1336.203 Section 1336.203 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE... Contracting for Construction 1336.203 Government estimate of construction costs. After award, the...

  7. 24 CFR 203.259 - Method of payment of MIP.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Method of payment of MIP. 203.259 Section 203.259 Housing and Urban Development Regulations Relating to Housing and Urban Development... § 203.259 Method of payment of MIP. The payment of any MIP under this subpart shall be made to...

  8. 32 CFR 203.15 - Method of payment.

    Science.gov (United States)

    2010-07-01

    ... ACTIVITIES § 203.15 Method of payment. The SAP set forth in FAR (48 CFR part 13) require purchase orders to... 32 National Defense 2 2010-07-01 2010-07-01 false Method of payment. 203.15 Section 203.15 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE...

  9. 20 CFR 404.203 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Computing Primary Insurance Amounts General § 404.203 Definitions. (a) General definitions. As used in this subpart— Ad hoc increase in primary insurance amounts means an increase in primary insurance...

  10. 40 CFR 156.203 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.203 Definitions. Terms in this subpart have the same meanings as they do in the Federal Insecticide, Fungicide, and Rodenticide Act,...

  11. 18 CFR 1304.203 - Vegetation management.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Vegetation management...-Owned Residential Access Shoreland § 1304.203 Vegetation management. No vegetation management shall be approved on TVA-owned Residential Access Shoreland until a Vegetation Management Plan meeting...

  12. 24 CFR 203.342 - Mortgage modification.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgage modification. 203.342... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Continuation of Insurance §...

  13. 7 CFR 765.203 - Protective advances.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE SPECIAL PROGRAMS DIRECT LOAN SERVICING-REGULAR Protecting the Agency's Security Interest § 765.203 Protective advances. When necessary to protect the Agency's security interest, costs incurred for the..., hazard, or flood insurance; (e) Pay harvesting costs; (f) Maintain Agency security instruments; (g)...

  14. 5 CFR 2606.203 - Granting access.

    Science.gov (United States)

    2010-01-01

    ....203 Administrative Personnel OFFICE OF GOVERNMENT ETHICS ORGANIZATION AND PROCEDURES PRIVACY ACT RULES...) When the data subject seeks to obtain original documentation, the Office and the other agencies... the records, adequate identification documentation will be required, e.g., an employee...

  15. 28 CFR 20.3 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Administration DEPARTMENT OF JUSTICE CRIMINAL JUSTICE INFORMATION SYSTEMS General Provisions § 20.3 Definitions... justice users with respect to the various systems managed by the FBI CJIS Division. (d) Criminal history... such information does not indicate the individual's involvement with the criminal justice system....

  16. Proposition 203: A Critical Metaphor Analysis

    Science.gov (United States)

    Johnson, Eric

    2005-01-01

    This project draws on Lakoff and Johnson's (1980) work with metaphor analysis to uncover the rhetorical strategies applied by supporters of the English for the Children organization during the 2000 Arizona Proposition 203 campaign. The data were collected from three sources: (a) "The Arizona Republic"; (b) the "East Valley Tribune"; and (c) the…

  17. 32 CFR 203.3 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... TECHNICAL ASSISTANCE FOR PUBLIC PARTICIPATION (TAPP) IN DEFENSE ENVIRONMENTAL RESTORATION ACTIVITIES § 203.3... or may be endangered by the release of hazardous substances at the facility. Applicant. Any group of... include a TAPP project description. Assistance provider. An individual, group of individuals, or...

  18. 5 CFR 340.203 - Technical assistance.

    Science.gov (United States)

    2010-01-01

    ... filling part-time positions; (4) Interpretations of part-time employment law, regulations and policy; (5...-TIME CAREER EMPLOYMENT (PART-TIME, SEASONAL, ON-CALL, AND INTERMITTENT) Regulatory Requirements-Part-Time Employment § 340.203 Technical assistance. (a) The Office of Personnel Management shall...

  19. Tank 241-C-203: Tank characterization plan

    Energy Technology Data Exchange (ETDEWEB)

    Schreiber, R.D.

    1995-03-06

    This document is a plan which serves as the contractual agreement between the Characterization Program, Sampling Operations, and WHC 222-S Laboratory. Scope of this plan is to provide guidance for sampling and analysis of samples for tank 241-C-203.

  20. 33 CFR 203.13 - Available assistance.

    Science.gov (United States)

    2010-07-01

    ... Secretary of the Army or his delegated nominee) to construct wells and to transport water for human... Section 203.13 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE EMERGENCY EMPLOYMENT OF ARMY AND OTHER RESOURCES, NATURAL DISASTER PROCEDURES Introduction §...

  1. 42 CFR 56.203 - Project elements.

    Science.gov (United States)

    2010-10-01

    ... Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR MIGRANT HEALTH SERVICES Grants for Planning and Developing Migrant Health Centers § 56.203 Project elements. A project for planning and developing a migrant health center supported under this subpart must: (a) Determine (by...

  2. 48 CFR 50.203 - General.

    Science.gov (United States)

    2010-10-01

    ... that will enhance the protection of the nation; and (2) Provide risk management and litigation management protections for sellers of QATTs and others in the supply and distribution chain. (b) The SAFETY....203 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT...

  3. 48 CFR 11.203 - Customer satisfaction.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Customer satisfaction. 11... PLANNING DESCRIBING AGENCY NEEDS Using and Maintaining Requirements Documents 11.203 Customer satisfaction... reflects the customer's needs and to obtain suggestions for corrective actions. Whenever practicable,...

  4. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  5. 7 CFR 1219.203 - Reapportionment of membership.

    Science.gov (United States)

    2010-01-01

    ... SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HASS AVOCADO PROMOTION, RESEARCH, AND INFORMATION Rules and Regulations § 1219.203 Reapportionment...

  6. 9 CFR 205.203 - Place of filing EFS.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Place of filing EFS. 205.203 Section 205.203 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE CLEAR TITLE-PROTECTION FOR PURCHASERS OF...

  7. 24 CFR 203.382 - Cancellation of hazard insurance.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Cancellation of hazard insurance. 203.382 Section 203.382 Housing and Urban Development Regulations Relating to Housing and Urban... Cancellation of hazard insurance. The mortgagee shall cancel any hazard insurance policy as of the date of...

  8. 48 CFR 203.570-3 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF DEFENSE GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 203.570-3 Contract clause. Use the clause at 252.203-7001, Prohibition on Persons... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clause....

  9. 49 CFR 1540.203 - Security threat assessment.

    Science.gov (United States)

    2010-10-01

    ... check conducted by TSA. (2) A security threat assessment conducted under 49 CFR part 1572 for the... 49 Transportation 9 2010-10-01 2010-10-01 false Security threat assessment. 1540.203 Section 1540... Security Threat Assessments § 1540.203 Security threat assessment. (a) Each operator subject to...

  10. 24 CFR 203.255 - Insurance of mortgage.

    Science.gov (United States)

    2010-04-01

    ... obligations under § 203.10 concerning informed consumer choice for prospective FHA mortgagors); (4) Not... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Insurance of mortgage. 203.255... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER...

  11. 24 CFR 203.316 - Termination by prepayment of mortgage.

    Science.gov (United States)

    2010-04-01

    ... mortgage. 203.316 Section 203.316 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Termination of Insurance...

  12. 48 CFR 1328.203-7 - Exclusion of individual sureties.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Exclusion of individual sureties. 1328.203-7 Section 1328.203-7 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE... Exclusion of individual sureties. The designee authorized to exclude an individual from acting as a...

  13. 48 CFR 1328.203 - Acceptability of individual sureties.

    Science.gov (United States)

    2010-10-01

    ... individual sureties. 1328.203 Section 1328.203 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE... Acceptability of individual sureties. (a) Contracting officers shall obtain the opinion of the Procurement Counsel as to the adequacy of the documents pledging the assets of an individual surety prior to...

  14. 48 CFR 28.203 - Acceptability of individual sureties.

    Science.gov (United States)

    2010-10-01

    ... individual sureties. 28.203 Section 28.203 Federal Acquisition Regulations System FEDERAL ACQUISITION... Acceptability of individual sureties. (a) An individual surety is acceptable for all types of bonds except position schedule bonds. The contracting officer shall determine the acceptability of individuals...

  15. 10 CFR 63.203 - Implementation of Subpart K.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Implementation of Subpart K. 63.203 Section 63.203 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Preclosure Public Health and Environmental Standards §...

  16. 48 CFR 1326.203 - Transition of work.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Transition of work. 1326.203 Section 1326.203 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SOCIOECONOMIC... work. The designee authorized to determine that transitioning response, relief, and/or...

  17. 48 CFR 26.203 - Transition of work.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Transition of work. 26.203... PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Disaster or Emergency Assistance Activities 26.203 Transition of work... emergency response work to local firms (e.g., unnecessarily broad scopes of work or long periods...

  18. 24 CFR 203.554 - Enforcement of late charges.

    Science.gov (United States)

    2010-04-01

    ... on the part of the mortgagor is the failure to pay a late charge or charges (§ 203.25), except as provided in § 203.556. (b) A late charge attributable to a particular installment payment due under the... mortgagor of his obligation to pay a late charge, such a charge may be deducted from any subsequent...

  19. 48 CFR 5416.203-4 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contract clauses. 5416.203-4 Section 5416.203-4 Federal Acquisition Regulations System DEFENSE LOGISTICS AGENCY, DEPARTMENT OF... established price or cost index may be derived from sales prices in the marketplace, quotes, or assessments...

  20. 41 CFR 109-38.203 - Agency identification.

    Science.gov (United States)

    2010-07-01

    ... Administrative Services, Logistics Management Division, Headquarters, using DOE Form 4250.2, “Requisition for... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Agency identification. 109-38.203 Section 109-38.203 Public Contracts and Property Management Federal Property...

  1. 24 CFR 570.203 - Special economic development activities.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES COMMUNITY DEVELOPMENT BLOCK GRANTS Eligible Activities... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Special economic development activities. 570.203 Section 570.203 Housing and Urban Development Regulations Relating to Housing and...

  2. 33 CFR 203.51 - Levee owner's manual.

    Science.gov (United States)

    2010-07-01

    ... Maintenance Manual specified by 33 CFR 208.10(a)(10) will fulfill the requirement of providing a levee owner's... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Levee owner's manual. 203.51... Program § 203.51 Levee owner's manual. (a) Authority. In accordance with section 202(f) of Public Law...

  3. 5 CFR 1201.203 - Proceedings for attorney fees.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Proceedings for attorney fees. 1201.203... PRACTICES AND PROCEDURES Attorney Fees (Plus Costs, Expert Witness Fees, and Litigation Expenses, Where Applicable), Consequential Damages, and Compensatory Damages § 1201.203 Proceedings for attorney fees....

  4. 41 CFR 105-54.203-2 - Active charters file.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Active charters file. 105-54.203-2 Section 105-54.203-2 Public Contracts and Property Management Federal Property Management... charters file. The GSA Committee Management Officer retains each original signed charter in a file...

  5. 48 CFR 236.203 - Government estimate of construction costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government estimate of...-ENGINEER CONTRACTS Special Aspects of Contracting for Construction 236.203 Government estimate of construction costs. Follow the procedures at PGI 236.203 for handling the Government estimate of...

  6. 29 CFR 1952.203 - Compliance staffing benchmarks.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Compliance staffing benchmarks. 1952.203 Section 1952.203... Compliance staffing benchmarks. Under the terms of the 1978 Court Order in AFL-CIO v. Marshall, compliance staffing levels (benchmarks) necessary for a “fully effective” enforcement program were required to...

  7. 24 CFR 203.400 - Method of payment.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Method of payment. 203.400 Section... FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Payment of Insurance Benefits § 203.400 Method of payment. If the application for insurance benefits is acceptable to the Commissioner payment...

  8. 42 CFR 447.203 - Documentation of payment rates.

    Science.gov (United States)

    2010-10-01

    ... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS PAYMENTS FOR SERVICES Payment Methods: General Provisions § 447.203 Documentation of payment rates. (a) The agency must maintain documentation of payment rates and make it... 42 Public Health 4 2010-10-01 2010-10-01 false Documentation of payment rates. 447.203 Section...

  9. 24 CFR 203.434 - Declaration of trust.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Declaration of trust. 203.434... Mortgage § 203.434 Declaration of trust. A sale of a beneficial interest in a group of insured mortgages... interest in a specific mortgage shall be made only pursuant to a declaration of trust, which has...

  10. Equilibrium and pre-equilibrium emissions in proton-induced reactions on 203,205Tl

    Indian Academy of Sciences (India)

    A Kaplan; A Aydin; E Tel; B Şarer

    2009-02-01

    In this study, the excitation functions for the reactions 203Tl(, )203Pb, 203Tl(, 3)203Pb, 203Tl(, 2)202Pb, 205Tl(, 4)202Pb, 203Tl(, 3)201Pb, 205Tl(, 5)201Pb, 203Tl(, 4)200Pb and 205Tl(, 6)200Pb have been calculated using pre-equilibrium and equilibrium reaction mechanisms. Calculated results based on hybrid model, geometry-dependent hybrid model and cascade-exciton model have been compared with the experimental data.

  11. 30 CFR 20.3 - Application procedures and requirements.

    Science.gov (United States)

    2010-07-01

    ..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MINE LAMPS OTHER THAN STANDARD CAP LAMPS § 20.3... accrediting organization; (2) Complete technical explanation of how the product complies with each...

  12. 40 CFR 59.203 - Standards for consumer products.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) NATIONAL VOLATILE ORGANIC COMPOUND EMISSION STANDARDS FOR CONSUMER AND COMMERCIAL PRODUCTS National Volatile Organic Compound Emission Standards for Consumer Products § 59.203 Standards for consumer... those consumer products that are registered under the Federal Insecticide, Fungicide, and...

  13. 46 CFR 108.203 - Berths and lockers.

    Science.gov (United States)

    2010-10-01

    ... EQUIPMENT Construction and Arrangement Accommodation Spaces § 108.203 Berths and lockers. (a) Each sleeping... pipe, ventilating duct, or other overhead installation. (i) Each berth must have a berth light....

  14. 18 CFR 701.203 - Schedule of fees.

    Science.gov (United States)

    2010-04-01

    ... ORGANIZATION Availability of Information § 701.203 Schedule of fees. (a) The Public Information Officer will to... requester is advised promptly upon physical receipt of the request of the anticipated cost and agrees...

  15. 14 CFR 171.203 - Requests for IFR procedure.

    Science.gov (United States)

    2010-01-01

    ...) NAVIGATIONAL FACILITIES NON-FEDERAL NAVIGATION FACILITIES VHF Marker Beacons § 171.203 Requests for IFR... beacon facility that he owns must submit the following information with that request: (1) A...

  16. Distribution of lead-203 in human peripheral blood in vitro

    International Nuclear Information System (INIS)

    In-vitro experiments using 203Pb were performed to identify the lead binding components in human peripheral blood. The distribution of lead in plasma, in the red cell membrane, and within the red cell was also investigated. Studies of the distribution of 203Pb in the whole blood showed that at a lead concentration of 2.45 μmol/l (50 μg/100 ml) about 94% of lead had been incorporated by the erythrocytes and 6% remained in the plasma. After extraction of lipid by a methanol/chloroform mixture, about 75% of the lead was found to be associated with the protein fraction. The lipid contained about 21% of the 203Pb, the remainder being in the aqueous plasma. SDS polyacrylamide gel electrophoresis of blood plasma showed that almost 90% of the 203Pb was present in the albumin fraction; the remainder was likely to be associated with high molecular weight globulins. Several binding sites were identified on the erythrocyte membrane. The high molecular weight component, about 130 000-230 000, was the most important 203Pb binding site. Chemical modification of membrane proteins suggested that the carboxyl groups are the major ligand responsible for most of the lead binding. SH groups of the membrane may have a minor role, but amino groups did not appear to affect the lead binding. The binding of lead to erythrocytes was not confined to membranes, over 80% of lead in blood penetrates into erythrocytes and binds to intracellular components. Gel chromatography of the haemolysate showed that over 90% of the 203Pb was attached to the haemoglobin molecule. (author)

  17. 75 FR 75693 - Rehabilitation Mortgage Insurance Underwriting Program Section 203(k); Notice of Proposed...

    Science.gov (United States)

    2010-12-06

    ... URBAN DEVELOPMENT Rehabilitation Mortgage Insurance Underwriting Program Section 203(k); Notice of... information: Title of Proposal: Rehabilitation Mortgage Insurance Underwriting Program Section 203(k). OMB... Program Development, Department of Housing and Urban Development, 451 7th Street, SW., Washington,...

  18. 48 CFR 627.203 - Patent indemnification of Government by contractor.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Patent indemnification of Government by contractor. 627.203 Section 627.203 Federal Acquisition Regulations System DEPARTMENT OF STATE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patents 627.203 Patent indemnification...

  19. 41 CFR 50-203.2 - Issuance of a formal complaint.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Issuance of a formal complaint. 50-203.2 Section 50-203.2 Public Contracts and Property Management Other Provisions Relating to... of the Walsh-Healey Public Contracts Act § 50-203.2 Issuance of a formal complaint. After a report...

  20. 32 CFR Appendix A to Part 203 - Technical Assistance for Public Participation Request Form

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Technical Assistance for Public Participation Request Form A Appendix A to Part 203 National Defense Department of Defense (Continued) OFFICE OF THE... DEFENSE ENVIRONMENTAL RESTORATION ACTIVITIES Pt. 203, App. A Appendix A to Part 203—Technical...

  1. 24 CFR 203.420 - Nature of Mutual Mortgage Insurance Fund.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Nature of Mutual Mortgage Insurance Fund. 203.420 Section 203.420 Housing and Urban Development Regulations Relating to Housing and Urban... and Distributive Shares § 203.420 Nature of Mutual Mortgage Insurance Fund. The Mutual...

  2. 14 CFR 1252.203 - Special benefits for children and the elderly.

    Science.gov (United States)

    2010-01-01

    ... elderly. 1252.203 Section 1252.203 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION... Determining Age Discrimination § 1252.203 Special benefits for children and the elderly. If a recipient operating a program or activity provides special benefits to the elderly or to children, such use of...

  3. 48 CFR 1652.203-70 - Misleading, deceptive, or unfair advertising.

    Science.gov (United States)

    2010-10-01

    ... unfair advertising. 1652.203-70 Section 1652.203-70 Federal Acquisition Regulations System OFFICE OF... CLAUSES Texts of FEHBP Clauses 1652.203-70 Misleading, deceptive, or unfair advertising. As prescribed in... Unfair Advertising (JAN 1991) (a) The Carrier agrees that any advertising material, including...

  4. 33 CFR 203.47 - Modifications to non-Federal flood control works.

    Science.gov (United States)

    2010-07-01

    ... flood control works. 203.47 Section 203.47 Navigation and Navigable Waters CORPS OF ENGINEERS... DISASTER PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program § 203.47 Modifications to non-Federal flood...

  5. 33 CFR 203.44 - Rehabilitation of non-Federal flood control works.

    Science.gov (United States)

    2010-07-01

    ... flood control works. 203.44 Section 203.44 Navigation and Navigable Waters CORPS OF ENGINEERS... DISASTER PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program § 203.44 Rehabilitation of non-Federal flood...

  6. 48 CFR 52.203-13 - Contractor Code of Business Ethics and Conduct.

    Science.gov (United States)

    2010-10-01

    ... Business Ethics and Conduct. 52.203-13 Section 52.203-13 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.203-13 Contractor Code of Business Ethics and Conduct. As prescribed in 3.1004(a), insert the following clause: Contractor Code of Business Ethics and Conduct (APR 2010) (a)...

  7. 24 CFR 203.422 - Right and liability under Mutual Mortgage Insurance Fund.

    Science.gov (United States)

    2010-04-01

    ... Mortgage Insurance Fund and Distributive Shares § 203.422 Right and liability under Mutual Mortgage... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Right and liability under Mutual Mortgage Insurance Fund. 203.422 Section 203.422 Housing and Urban Development Regulations Relating...

  8. 24 CFR 4001.203 - Calculation of upfront and annual mortgage insurance premiums for Program mortgages.

    Science.gov (United States)

    2010-04-01

    ... mortgage insurance premiums for Program mortgages. 4001.203 Section 4001.203 Housing and Urban Development....203 Calculation of upfront and annual mortgage insurance premiums for Program mortgages. (a) Applicable premiums. Any mortgage presented for endorsement under section 257 on or after October 1,...

  9. 30 CFR 203.72 - Can my lease receive more than one suspension volume?

    Science.gov (United States)

    2010-07-01

    ... volume? 203.72 Section 203.72 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR... receive more than one suspension volume? Yes. You may apply for royalty relief that involves more than one suspension volume under § 203.62 in two circumstances. (a) Each field that includes your lease may receive...

  10. 29 CFR 825.203 - Scheduling of intermittent or reduced schedule leave.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Scheduling of intermittent or reduced schedule leave. 825.203 Section 825.203 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT... Family and Medical Leave Act § 825.203 Scheduling of intermittent or reduced schedule leave....

  11. 48 CFR 252.203-7002 - Requirement to Inform Employees of Whistleblower Rights.

    Science.gov (United States)

    2010-10-01

    ... Employees of Whistleblower Rights. 252.203-7002 Section 252.203-7002 Federal Acquisition Regulations System... Whistleblower Rights. As prescribed in 203.970, use the following clause: Requirement To Inform Employees of Whistleblower Rights (JAN 2009) The Contractor shall inform its employees in writing of employee...

  12. 48 CFR 12.203 - Procedures for solicitation, evaluation, and award.

    Science.gov (United States)

    2010-10-01

    ... solicitation, evaluation, and award. 12.203 Section 12.203 Federal Acquisition Regulations System FEDERAL... Acquisition of Commercial Items 12.203 Procedures for solicitation, evaluation, and award. Contracting... conjunction with the policies and procedures for solicitation, evaluation and award prescribed in part...

  13. 47 CFR 54.203 - Designation of eligible telecommunications carriers for unserved areas.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Designation of eligible telecommunications carriers for unserved areas. 54.203 Section 54.203 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... Support § 54.203 Designation of eligible telecommunications carriers for unserved areas. (a) If no...

  14. 33 CFR 203.61 - Emergency water supplies due to contaminated water source.

    Science.gov (United States)

    2010-07-01

    ... Water Act (see 40 CFR 141), is exceeded. (ii) The water supply has been identified as a source of... contaminated water source. 203.61 Section 203.61 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT... PROCEDURES Emergency Water Supplies: Contaminated Water Sources and Drought Assistance § 203.61...

  15. 5 CFR 870.203 - Post-election BIA.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Post-election BIA. 870.203 Section 870...-election BIA. (a) The BIA of an individual who elects a Living Benefit under subpart K of this part is the amount of insurance left after the effective date of the Living Benefit election. This amount is...

  16. 5 CFR 847.203 - Elections of CSRS coverage.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Elections of CSRS coverage. 847.203... REGULATIONS (CONTINUED) ELECTIONS OF RETIREMENT COVERAGE BY CURRENT AND FORMER EMPLOYEES OF NONAPPROPRIATED FUND INSTRUMENTALITIES Elections To Continue Retirement Coverage After a Qualifying Move §...

  17. 5 CFR 950.203 - Public accountability standards.

    Science.gov (United States)

    2010-01-01

    ... Section 950.203 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... insure organizations wishing to solicit donations from Federal employees in the workplace are portraying... organization is directed by an active and responsible governing body whose members have no material conflict...

  18. 46 CFR 16.203 - Employer, MRO, and SAP responsibilities.

    Science.gov (United States)

    2010-10-01

    ... meet the training requirements and follow the procedures in 49 CFR Part 40. (2) MROs may report... and follow the procedures in 49 CFR Part 40. ... 46 Shipping 1 2010-10-01 2010-10-01 false Employer, MRO, and SAP responsibilities. 16.203...

  19. 27 CFR 555.203 - Types of magazines.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Types of magazines. 555... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Storage § 555.203 Types of magazines. For purposes of this part, there are five types of magazines. These types, together with the classes...

  20. 10 CFR 830.203 - Unreviewed safety question process.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Unreviewed safety question process. 830.203 Section 830... Unreviewed safety question process. (a) The contractor responsible for a hazard category 1, 2, or 3 DOE... a procedure for its USQ process on a schedule that allows DOE approval in a safety evaluation...

  1. 48 CFR 43.203 - Change order accounting procedures.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Change order accounting... CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 43.203 Change order accounting procedures. (a) Contractors' accounting systems are seldom designed to segregate the costs of performing changed...

  2. 24 CFR 203.350 - Assignment of mortgage.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Assignment of mortgage. 203.350... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Assignment of Mortgage §...

  3. 20 CFR 416.203 - Initial determinations of SSI eligibility.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Initial determinations of SSI eligibility... INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility General § 416.203 Initial determinations of SSI eligibility. (a) What happens when you apply for SSI benefits. When you apply for SSI benefits we will ask...

  4. 24 CFR 203.270 - Open-end insurance charges.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Open-end insurance charges. 203.270... (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND... SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Open-End Insurance Charges-All...

  5. 48 CFR 828.203-7 - Exclusion of individual sureties.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Exclusion of individual... Exclusion of individual sureties. The DSPE may make the determinations referenced in FAR 28.203-7: (a) To exclude individuals from acting as surety on bonds; and (b) To accept bonds from individuals named on...

  6. 24 CFR 203.361 - Acceptance of property by Commissioner.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Acceptance of property by... AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Claim Procedure § 203.361 Acceptance of property by Commissioner. Upon receipt of notice of property transfer the Commissioner...

  7. 40 CFR 61.203 - Radon monitoring and compliance procedures.

    Science.gov (United States)

    2010-07-01

    ... disposal of phosphogypsum or for water management, the stack ceases to be in inactive status and the owner... stack for disposal of phosphogypsum or water management, the stack will once again become inactive and... for Radon Emissions From Phosphogypsum Stacks § 61.203 Radon monitoring and compliance procedures....

  8. 48 CFR 1631.203-70 - Allocation techniques.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Allocation techniques. 1631... PRINCIPLES AND PROCEDURES Contracts With Commercial Organizations 1631.203-70 Allocation techniques. (a... preferred allocation technique is one that shows the consumption of resources in performance of...

  9. 48 CFR 23.203 - Energy-efficient products.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Energy-efficient products... SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water Efficiency and Renewable Energy 23.203...

  10. 31 CFR 539.203 - Evasions; attempts; conspiracies.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Evasions; attempts; conspiracies. 539... REGULATIONS Prohibitions § 539.203 Evasions; attempts; conspiracies. Any transaction by any United States... prohibited. Any conspiracy formed for the purpose of engaging in a transaction prohibited by this part...

  11. 48 CFR 836.203 - Government estimate of construction costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Government estimate of... Contracting for Construction 836.203 Government estimate of construction costs. The overall amount of the Government estimate must not be disclosed until after award of the contract. After award, the...

  12. 48 CFR 436.203 - Government estimate of construction costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Government estimate of... Contracting for Construction 436.203 Government estimate of construction costs. For acquisitions using sealed bid procedures, the contracting officer may disclose the overall amount of the Government's...

  13. 27 CFR 31.203 - Possession of used liquor bottles.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Possession of used liquor... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS ALCOHOL BEVERAGE DEALERS Reuse and Possession of Used Liquor Bottles § 31.203 Possession of used liquor bottles. The possession of used liquor bottles by any...

  14. 20 CFR 633.203 - Review of funding request.

    Science.gov (United States)

    2010-04-01

    ... 633.203 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR MIGRANT AND.... The SGA will identify all review standards including: (a) An understanding of the problems of migrant... capability to administer effectively a diversified employability development program for migrant and...

  15. 24 CFR 203.493 - Declaration of trust.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Declaration of trust. 203.493... Declaration of trust. A sale of a beneficial interest in a group of insured loans, where the interest to be... be made only pursuant to a declaration of trust, which has been approved by the Commissioner prior...

  16. 24 CFR 203.604 - Contact with the mortgagor.

    Science.gov (United States)

    2010-04-01

    ... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Servicing Responsibilities Mortgagee Action and Forbearance § 203.604... the mortgage are unpaid. If default occurs in a repayment plan arranged other than during a...

  17. 24 CFR 1003.203 - Special economic development activities.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Special economic development... Eligible Activities § 1003.203 Special economic development activities. A grantee may use ICDBG funds for special economic development activities in addition to other activities authorized in this subpart...

  18. 33 CFR 203.72 - Eligibility criteria and procedures.

    Science.gov (United States)

    2010-07-01

    ..., DEPARTMENT OF DEFENSE EMERGENCY EMPLOYMENT OF ARMY AND OTHER RESOURCES, NATURAL DISASTER PROCEDURES Advance Measures § 203.72 Eligibility criteria and procedures. (a) Threat of flooding. An imminent threat of... readily apparent that damages will be incurred if preventive action is not taken immediately. (b)...

  19. 24 CFR 203.288 - Discontinuance of adjusted premium charge.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Discontinuance of adjusted premium... Premium § 203.288 Discontinuance of adjusted premium charge. Notwithstanding any provision in the mortgage instrument, there shall be no adjusted mortgage insurance premium due the Commissioner on account of...

  20. 203Hg binding in the liver and kidney of the frog, Rana tigrina

    International Nuclear Information System (INIS)

    Following a single i.p. dose of the radioisotope, 203Hg was found to accumulate in both the high and low molecular weight (MW) fractions of the kidney and liver of the frog. The course of 203Hg appearance in the 2 fractions varied in the liver; 203Hg was exclusively associated with the higher MW fractions at 2 days whereas the radiotracer appeared in both low and high MW fractions at 4 and 7 days after administration. In the kidneys, however, 203Hg was associated with high and low MW fractions at all the intervals studied. Low MW 203Hg binding fraction appeared to be a metallothionein-like substance. (Auth.)

  1. 30 CFR 203.68 - What pre-application costs will MMS consider in determining economic viability?

    Science.gov (United States)

    2010-07-01

    ... determining economic viability? 203.68 Section 203.68 Mineral Resources MINERALS MANAGEMENT SERVICE... § 203.68 What pre-application costs will MMS consider in determining economic viability? (a) We will not consider ineligible costs as set forth in § 203.89(h) in determining economic viability for purposes...

  2. The expression and function of microRNA-203 in lung cancer.

    Science.gov (United States)

    Jin, Jianhua; Deng, Jianzhong; Wang, Fang; Xia, Xiyi; Qiu, Tiefeng; Lu, Wenbin; Li, Xianwen; Zhang, Hua; Gu, Xiaoyan; Liu, Yungang; Cao, Weiguo; Shao, Wenlong

    2013-02-01

    We aimed to determine the expression of microRNA-203 (miR-203) in human lung cancer cell lines and to evaluate the effects of miR-203 by targeting survivin, on the lung cancer cell line 95-D to provide potential new strategies for treating lung cancer. The expression of miR-203 was detected using quantitative real-time PCR (qRT-PCR) in the in vitro cultured lung cancer cells A549, HCC827, NCI-H1299, and 95-D as well as in normal human bronchial epithelial cells. Following a 72-h transfection with the miR-203 precursor in 95-D lung cancer cells, the change in miR-203 expression was detected using qRT-PCR and the resulting effect on survivin protein expression was ascertained by Western blot analysis. The influence of miR-203 on the viability of 95-D lung cancer cells was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The effect of miR-203 on 95-D cell proliferation was analyzed using flow cytometry. The consequences of miR-203 expression on 95-D cell apoptosis were analyzed by Annexin V/propidium iodide double staining coupled with flow cytometry. The role of miR-203 in the invasive potential of 95-D cells was studied using a transwell chamber assay. A luciferase reporter gene system was used to verify that survivin is a target gene for miR-203. By qRT-PCR, the expression of miR-203 was lower in lung cancer cells than in normal bronchial epithelial cells (p transfection with the miR-203 precursor (p transfection with the miR-203 precursor, survivin protein levels in 95-D cells were significantly decreased (p transfection with the miR-203 precursor (p < 0.05). The expression of miR-203 is downregulated in lung cancer cells. miR-203 negatively regulates survivin protein expression and inhibits the proliferation and invasion of lung cancer cells. Therapeutic strategies that enhance miR-203 expression or silence survivin could potentially benefit lung cancer patients. PMID:23073851

  3. MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines

    DEFF Research Database (Denmark)

    Viticchiè, Giuditta; Lena, Anna Maria; Latina, Alessia;

    2011-01-01

    transition and invasion of healthy tissues (usually bones). MicroRNA-203 (miR-203) is a tumor suppressor microRNA often silenced in different malignancies. Here, we show that miR-203 is downregulated in clinical primary prostatic tumors compared to normal prostate tissue, and in metastatic prostate cancer...... cell lines compared to normal epithelial prostatic cells. Overexpression of miR-203 in brain or bone metastatic prostate cell lines (DU145 and PC3) is sufficient to induce a mesenchymal to epithelial transition with inhibition of cell proliferation, migration and invasiveness. We have identified CKAP2......, LASP1, BIRC5, WASF1, ASAP1 and RUNX2 as new miR-203 direct target mRNAs involved in these events. Therefore, miR-203 could be a potentially new prognostic marker and therapeutic target in metastatic prostate cancer....

  4. 21 CFR 74.203 - FD&C Green No. 3.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false FD&C Green No. 3. 74.203 Section 74.203 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL LISTING OF COLOR ADDITIVES SUBJECT TO CERTIFICATION Foods § 74.203 FD&C Green No. 3. (a) Identity. (1) The color additive FD&C Green No. 3 is principally the...

  5. Some health physics aspects of working with 203Hg in university research.

    Science.gov (United States)

    Belanger, M; Westin, A; Barfuss, D W

    2001-02-01

    The radioisotope 203Hg is used in university toxicology research experiments. When our commercial vendor ceased the production of the high specific activity 203Hg we required, an alternative source was sought. Other commercial sources were investigated without success leaving the synthesis of this radioisotope to us. This paper outlines the method we used to synthesize 203Hg and provides a summary of our results to date and a discussion of our experiences.

  6. Tank 241-B-203 Push Mode Core Sampling and Analysis Plan

    Energy Technology Data Exchange (ETDEWEB)

    Jo, J. [Westinghouse Hanford Co., Richland, WA (United States)

    1995-05-16

    This Sampling and Analysis Plan (SAP) will identify characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements in accordance with the Tank Safety Screening Data Quality Objective (Babad and Redus 1994). This Data Quality Objective (DQO) is described in the Tank Characterization Plan (Jo, 1995) for tank 241-B-203 (B-203). This SAP will also identify procedures and requirements for collecting and characterizing samples from tank B-203 by the core sampling method.

  7. 21 CFR 203.50 - Requirements for wholesale distribution of prescription drugs.

    Science.gov (United States)

    2010-04-01

    ... sale, purchase, or trade of such drug. This identifying statement shall include: (1) The proprietary... prescription drugs. 203.50 Section 203.50 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL PRESCRIPTION DRUG MARKETING Wholesale Distribution §...

  8. 5 CFR 2638.203 - Duties of the designated agency ethics official.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Duties of the designated agency ethics official. 2638.203 Section 2638.203 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS OFFICE OF GOVERNMENT ETHICS AND EXECUTIVE AGENCY ETHICS PROGRAM RESPONSIBILITIES Designated Agency...

  9. 48 CFR 2152.203-70 - Misleading, deceptive, or unfair advertising.

    Science.gov (United States)

    2010-10-01

    ... unfair advertising. 2152.203-70 Section 2152.203-70 Federal Acquisition Regulations System OFFICE OF..., deceptive, or unfair advertising. As prescribed in 2103.571, insert the following clause: Misleading, Deceptive, or Unfair Advertising (OCT 2005) The Contractor agrees that any advertising material...

  10. 24 CFR 203.52 - Acceptance of individual residential water purification equipment.

    Science.gov (United States)

    2010-04-01

    ... National Primary Drinking Water requirements, 40 CFR parts 141 and 142.) (4) There exists a Plan providing... residential water purification equipment. 203.52 Section 203.52 Housing and Urban Development Regulations... water purification equipment. If a property otherwise eligible for insurance under this part does...

  11. 33 CFR 203.48 - Inspection guidelines for non-Federal flood control works.

    Science.gov (United States)

    2010-07-01

    ...-Federal flood control works. 203.48 Section 203.48 Navigation and Navigable Waters CORPS OF ENGINEERS... DISASTER PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm..., construction, and maintenance of non-Federal flood control works. The guidelines are not intended to...

  12. 5 CFR 451.203 - Responsibilities of the Office of Personnel Management.

    Science.gov (United States)

    2010-01-01

    ... Personnel Management. 451.203 Section 451.203 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL... Management. (a) The Office of Personnel Management, in accordance with Executive Order 10717, as amended... and recommend to the President which career employees should receive this award. (b) Under...

  13. 9 CFR 93.203 - Ports designated for the importation of poultry.

    Science.gov (United States)

    2010-01-01

    ... of poultry. 93.203 Section 93.203 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF CERTAIN ANIMALS, BIRDS, FISH, AND POULTRY, AND CERTAIN ANIMAL, BIRD, AND...

  14. 47 CFR 101.203 - Communications concerning safety of life and property.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Communications concerning safety of life and property. 101.203 Section 101.203 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY... concerning safety of life and property. (a) Handling and transmission of messages concerning the safety...

  15. 10 CFR 490.203 - Light Duty Alternative Fueled Vehicle Plan.

    Science.gov (United States)

    2010-01-01

    ... Section 490.203 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.203 Light Duty Alternative Fueled Vehicle Plan. (a) General Provisions... fleets, a State may follow a Light Duty Alternative Fueled Vehicle Plan that has been approved by...

  16. 24 CFR 203.256 - Insurance of open-end advance.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Insurance of open-end advance. 203... Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF... Insurance § 203.256 Insurance of open-end advance. Insurance on an open-end advance will be evidenced...

  17. 21 CFR 20.3 - Certification and authentication of Food and Drug Administration records.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Certification and authentication of Food and Drug Administration records. 20.3 Section 20.3 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... authentication of Food and Drug Administration records. (a) Upon request, the Food and Drug Administration...

  18. 5 CFR 330.203 - Eligibility due to reduction in force.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Eligibility due to reduction in force. 330.203 Section 330.203 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE... Eligibility due to reduction in force. (a) To apply for the RPL, an employee must meet all the...

  19. 9 CFR 203.15 - Trust benefits under sections 206 and 207 of the Act.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Trust benefits under sections 206 and 207 of the Act. 203.15 Section 203.15 Animals and Animal Products GRAIN INSPECTION, PACKERS AND..., live poultry seller or grower, to preserve his interest in the statutory trust, must give...

  20. 48 CFR 1836.203 - Government estimate of construction costs.(NASA supplements paragraph (c))

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Government estimate of construction costs.(NASA supplements paragraph (c)) 1836.203 Section 1836.203 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  1. 38 CFR 1.203 - Information to be reported to VA Police.

    Science.gov (United States)

    2010-07-01

    ... reported to VA Police. 1.203 Section 1.203 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... be reported to VA Police. Information about actual or possible violations of criminal laws related to... occurs on VA premises, will be reported by VA management officials to the VA police component...

  2. 7 CFR 760.203 - Eligible losses, adverse weather, and other loss conditions.

    Science.gov (United States)

    2010-01-01

    ... to, flood, freeze, hurricane, hail, tidal surge, volcanic eruption, and wildfire on non-Federal land... 7 Agriculture 7 2010-01-01 2010-01-01 false Eligible losses, adverse weather, and other loss conditions. 760.203 Section 760.203 Agriculture Regulations of the Department of Agriculture (Continued)...

  3. 50 CFR 226.203 - Critical habitat for northern right whales.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Critical habitat for northern right whales. 226.203 Section 226.203 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND... Critical habitat for northern right whales. (a) Great South Channel. The area bounded by 41°40′ N/69°45′...

  4. 17 CFR 275.203(b)(3)-1 - Definition of “client” of an investment adviser.

    Science.gov (United States)

    2010-04-01

    ... generally to the public as an investment adviser, within the meaning of section 203(b)(3) of the Act (15 U.S... than the United States, and is regulated as a public investment company under the laws of the country... investment adviser. 275.203(b)(3)-1 Section 275.203(b)(3)-1 Commodity and Securities Exchanges SECURITIES...

  5. 24 CFR 203.439a - Mortgages on property in Allegany Reservation of Seneca Nation of Indians authorized by section...

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgages on property in Allegany Reservation of Seneca Nation of Indians authorized by section 203(q) of the National Housing Act. 203.439a... Reservation of Seneca Indians § 203.439a Mortgages on property in Allegany Reservation of Seneca Nation...

  6. 24 CFR 203.666 - Processing defaulted mortgages on property in Allegany Reservation of Seneca Nation of Indians.

    Science.gov (United States)

    2010-04-01

    ... property in Allegany Reservation of Seneca Nation of Indians. 203.666 Section 203.666 Housing and Urban... INSURANCE Servicing Responsibilities Assignment and Forbearance-Property in Allegany Reservation of Seneca Indians § 203.666 Processing defaulted mortgages on property in Allegany Reservation of Seneca Nation...

  7. 30 CFR 203.44 - What administrative steps must I take to use the royalty suspension volume?

    Science.gov (United States)

    2010-07-01

    ... 30 CFR part 250, subpart L. (d) You must provide the information in paragraph (b) of this section by... the royalty suspension volume? 203.44 Section 203.44 Mineral Resources MINERALS MANAGEMENT SERVICE... Relief § 203.44 What administrative steps must I take to use the royalty suspension volume? (a) You...

  8. 14 CFR 203.4 - Montreal Agreement as part of airline-passenger contract and conditions of carriage.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Montreal Agreement as part of airline-passenger contract and conditions of carriage. 203.4 Section 203.4 Aeronautics and Space OFFICE OF THE... CONVENTION LIABILITY LIMITS AND DEFENSES § 203.4 Montreal Agreement as part of airline-passenger contract...

  9. 36 CFR 223.203 - Indirect substitution exception for National Forest System timber from within Washington State.

    Science.gov (United States)

    2010-07-01

    ... 36 CFR 223.203, the prohibition contained in section 490(b) of the Act (16 U.S.C. 620b) applies to me... from the prohibition against indirect substitution in section 490(b) of the Act, a person must have... exception for National Forest System timber from within Washington State. 223.203 Section 223.203...

  10. Porcine ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1/CD203a)

    DEFF Research Database (Denmark)

    Petersen, Cathrine Bie; Hillig, Ann-Britt Nygaard; Viuff, Birgitte;

    2007-01-01

    /phosphodiesterase 1 (NPP1/CD203a). The porcine NPP1/CD203a encoding gene was mapped to chromosome 1 using a radiation hybrid panel, and transcription was investigated by RT-PCR analysis of several tissues. The cDNA was cloned and introduced into COS7 cells resulting in expression of functionally active enzyme...... and verification of the specificity of an SWC9 reacting monoclonal antibody. The antibody was used for immunohistochemical examination of various porcine tissues. Most prominent expression of NPP1/CD203a was found in lung macrophages and liver sinusoids....

  11. COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Qi, Huan; Zuo, Dai-Ying; Bai, Zhao-Shi; Xu, Jing-Wen; Li, Zeng-Qiang [Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang (China); Shen, Qi-Rong; Wang, Zhi-Wei [Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang (China); Zhang, Wei-Ge, E-mail: zhangweige2000@sina.com [Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang (China); Wu, Ying-Liang, E-mail: yingliang_1016@163.com [Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang (China)

    2014-12-12

    Highlights: • COH-203 exhibits anti-hepatoma effects in vitro and in vivo with low toxicity. • COH-203 inhibits tubulin polymerization. • COH-203 induces mitotic arrest followed by mitotic slippage in BEL-7402 cells. • COH-203 induces p53-dependent senescence in BEL-7402 cells. - Abstract: 5-(3-Hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-3H-1, 2-dithiol-3-one (COH-203) is a novel synthesized analogue of combretastatin A-4 that can be classified as a microtubule inhibitor. In this study, we evaluated the anti-hepatoma effect of COH-203 in vitro and in vivo and explored the underlying molecular mechanisms. COH-203 was shown to be more effective in inhibiting the proliferation of liver cancer cells compared with normal liver cells. COH-203 also displayed potent anti-tumor activity in a hepatocellular carcinoma xenograft model without significant toxicity. Mechanistic studies demonstrated that treatment with COH-203 induced mitotic arrest by inhibiting tubulin polymerization in BEL-7402 liver cancer cells. Long-term COH-203 treatment in BEL-7402 cells led to mitotic slippage followed by senescence via the p14{sup Arf}–p53–p21 and p16{sup INK4α}–Rb pathways. Furthermore, suppression of p53 via pifithrin-α (p53 inhibitor) and p53-siRNA attenuated COH-203-induced senescence in BEL-7402 cells, suggesting that COH-203 induced senescence p53-dependently. In conclusion, we report for the first time that COH-203, one compound in the combretastatin family, promotes anti-proliferative activity through the induction of p-53 dependent senescence. Our findings will provide a molecular rationale for the development of COH-203 as a promising anti-tumor agent.

  12. 49 CFR 236.203 - Hand operated crossover between main tracks; protection.

    Science.gov (United States)

    2010-10-01

    ..., AND APPLIANCES Automatic Block Signal Systems Standards § 236.203 Hand operated crossover between main... crossover is occupied by a train, locomotive or car in such a manner as to foul the main track. It shall...

  13. Molecular cloning of a cDNA related to vernalization(verc203) in winter wheat

    Institute of Scientific and Technical Information of China (English)

    种康; 谭克辉; 黄华梁; 梁厚果

    1995-01-01

    A cDNA clone related to the vernalization in winter wheat(verc203)was harvested from the en-riched cold-induced cDNA library of 10~4 pfu with differential screening.The insert of verc203 in λ gt10 vector wassubcloned into the sites between BamH Ⅰ and Hind Ⅲ in pUC19 plasmid after being amplified with PCR.the analysis of the Northern blotting with a probe of verc203 indicated that the verc203 has a negative signalfor the control and the devernalized mRNA and a positive signal for the vernalized winter wheat and non-vernalized spring wheat at about 2.6 kb.

  14. MiRNA-203 suppresses cell proliferation, migration and invasion in colorectal cancer via targeting of EIF5A2

    Science.gov (United States)

    Deng, Biao; Wang, Bin; Fang, Jiaqing; Zhu, Xuchao; Cao, Zhongwei; Lin, Qi; Zhou, Lisheng; Sun, Xing

    2016-01-01

    While it is known that miR-203 is frequently downregulated in many types of human cancer, little is known regarding its expression and functional role in colorectal cancer (CRC). In this study, we aimed to investigate the expression and the potential mechanisms of miR-203 in colorectal cancer. MiR-203 was significantly downregulated in CRC tissues compared with matched normal adjacent tissues. Our clinical data show that decreased miR-203 was associated with an advanced clinical tumor-node-metastasis stage, lymph node metastasis, and poor survival in CRC patients. Furthermore, externally induced expression of miR-203 significantly inhibited CRC cell proliferation and invasion in vitro and in vivo. Mechanistically, we identified EIF5A2 as a direct and functional target of miR-203. The levels of miR-203 were inversely correlated with levels of the EIF5A2 in the CRC tissues. Restoration of EIF5A2 in the miR-203-overexpressing CRC cells reversed the suppressive effects of miR-203. Our results demonstrate that miR-203 serves as a tumor suppressor gene and may be useful as a new potential therapeutic target in CRC. PMID:27376958

  15. A norming study and library of 203 dance movements.

    Science.gov (United States)

    Christensen, Julia F; Nadal, Marcos; Cela-Conde, Camilo José

    2014-01-01

    Dance stimuli have been used in experimental studies of (i) how movement is processed in the brain; (ii) how affect is perceived from bodily movement; and (iii) how dance can be a source of aesthetic experience. However, stimulus materials across--and even within--these three domains of research have varied considerably. Thus, integrative conclusions remain elusive. Moreover, concerns have been raised that the movements selected for such stimuli are qualitatively too different from the actual art form dance, potentially introducing noise in the data. We propose a library of dance stimuli which responds to the stimuli requirements and design criteria of these three areas of research, while at the same time respecting a dance art-historical perspective, offering greater ecological validity as compared with previous dance stimulus sets. The stimuli are 5-6 s long video clips, selected from genuine ballet performances. Following a number of coding experiments, the resulting stimulus library comprises 203 ballet dance stimuli coded in (i) 25 qualitative and quantitative movement variables; (ii) affective valence and arousal; and (iii) the aesthetic qualities beauty, liking, and interest. An Excel spreadsheet with these data points accompanies this manuscript, and the stimuli can be obtained from the authors upon request.

  16. Prognostic value of microRNA-203a expression in breast cancer.

    Science.gov (United States)

    Gomes, Bruno Costa; Martins, Manuela; Lopes, Paulina; Morujão, Inês; Oliveira, Mário; Araújo, António; Rueff, José; Rodrigues, António Sebastião

    2016-09-01

    Tumor heterogeneity and the poor outcome of breast cancer (BC) patients have led researchers to define new markers of this disease. In recent years, microRNA expression patterns have proven to be valuable disease indicators. The level of miR-203a, in particular, was shown to be altered in different types of cancer. The objective of the present study was to assess the relationship between miR-203a expression and clinicopathological features of BC in a Portuguese cohort. The expression levels of miR‑203a were analyzed in 109 formalin‑fixed paraffin-embedded paired normal and tumor tissue samples. Significant overexpression of miR‑203a in the tumor tissues was found (1.7-fold higher) compared to the expression in the normal adjacent tissues (p=0.003). In addition, several clinicopathological characteristics presented an association with higher miR-203a expression levels. Tumors with diameter ≤18.5 mm (1.5-fold; p=0.019), tumors positive for estrogen receptor (fold-change, 1.71; p=0.042), progesterone receptor (fold-change, 1.50; p=0.046) and negative for HER2 (fold-change, 1.50; p=0.016) and high Ki-67 index (fold-change, 2.60; p=0.024) presented a significant difference in miR-203a expression compared with adjacent normal tissues. Tumors without invasion of lymph nodes also presented higher expression of miR-203a (fold-change, 2.40; p=0.004). With regard to histological classification, ductal carcinomas in situ (fold-change, 2.20; p=0.028) and invasive carcinoma NOS (fold-change, 1.71; p=0.009) displayed significantly higher expression of miR-203a. Moreover, we found a significant downregulation of miR-203a with increased stage in invasive lobular carcinomas, suggesting that miR-203a could represent a potential marker to discriminate stages in invasive lobular carcinomas. PMID:27431784

  17. miR-203 inhibits melanoma invasive and proliferative abilities by targeting the polycomb group gene BMI1

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Xiao [Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China); Sun, Yong [Department of Burn and Plastic Surgery, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300 (China); Han, Siqi [Department of Medical Oncology, Jinling Hospital, Nanjing 210002 (China); Zhu, Wei [Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China); Zhang, Haiping, E-mail: zhanghaiping_2000@163.com [Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053 (China); Lian, Shi, E-mail: lianshi_2020@163.com [Department of Dermatology and Venereal Disease, Capital Medical University, Beijing 100069 (China)

    2015-01-02

    Highlights: • First reported deregulation of miR-203 and up-regulation of BMI1 in metastatic melanoma. • miR-203 decreased BMI1 expression by directly binding to 3′UTR. • Further found miR-203 overexpression suppressed cell invasion and stemness. • Re-expression of BMI1 rescued miR-203-mediated suppression. • miR-203-BMI1 axis may be potential therapeutic targets of melanoma metastasis. - Abstract: Metastasis is the major problem in malignant melanoma, posing a therapeutic challenge to clinicians. The investigation of the underlying mechanism driving this progress remains a large unmet need. In this study, we revealed a miR-203-BMI1 axis that regulated melanoma metastasis. We found significantly deregulation of miR-203 and up-regulation of BMI1 in melanoma, particularly in metastatic melanoma. An inverse correlation between the levels of miR-203 and BMI1 was further observed in melanoma tissues and cell lines. We also identified BMI1 as a downstream target gene of miR-203, which bound to the 3′UTR of BMI1. Overexpression of miR-203 was associated with decreased BMI1 expression and impaired cell invasion and tumor sphere formation activities. Re-expression of BMI1 markedly rescued miR-203-mediated suppression of these events. Taken together, our results demonstrated that miR-203 regulated melanoma invasive and proliferative abilities in part by targeting BMI1, providing new insights into potential mechanisms of melanoma metastasis.

  18. miR-203 inhibits melanoma invasive and proliferative abilities by targeting the polycomb group gene BMI1

    International Nuclear Information System (INIS)

    Highlights: • First reported deregulation of miR-203 and up-regulation of BMI1 in metastatic melanoma. • miR-203 decreased BMI1 expression by directly binding to 3′UTR. • Further found miR-203 overexpression suppressed cell invasion and stemness. • Re-expression of BMI1 rescued miR-203-mediated suppression. • miR-203-BMI1 axis may be potential therapeutic targets of melanoma metastasis. - Abstract: Metastasis is the major problem in malignant melanoma, posing a therapeutic challenge to clinicians. The investigation of the underlying mechanism driving this progress remains a large unmet need. In this study, we revealed a miR-203-BMI1 axis that regulated melanoma metastasis. We found significantly deregulation of miR-203 and up-regulation of BMI1 in melanoma, particularly in metastatic melanoma. An inverse correlation between the levels of miR-203 and BMI1 was further observed in melanoma tissues and cell lines. We also identified BMI1 as a downstream target gene of miR-203, which bound to the 3′UTR of BMI1. Overexpression of miR-203 was associated with decreased BMI1 expression and impaired cell invasion and tumor sphere formation activities. Re-expression of BMI1 markedly rescued miR-203-mediated suppression of these events. Taken together, our results demonstrated that miR-203 regulated melanoma invasive and proliferative abilities in part by targeting BMI1, providing new insights into potential mechanisms of melanoma metastasis

  19. 13 CFR 127.203 - What are the rules governing the requirement that economically disadvantaged women must own EDWOSBs?

    Science.gov (United States)

    2010-01-01

    ... in the same or similar line of business. (b) Limitation on personal net worth. In order to be... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are the rules governing the requirement that economically disadvantaged women must own EDWOSBs? 127.203 Section 127.203 Business...

  20. 24 CFR 203.43j - Eligibility of mortgages on Allegany Reservation of Seneca Nation of Indians.

    Science.gov (United States)

    2010-04-01

    ... Allegany Reservation of Seneca Nation of Indians. 203.43j Section 203.43j Housing and Urban Development... Reservation of Seneca Nation of Indians. A mortgage on a leasehold estate covering a one- to four-family residence located on the Allegany Reservation of the Seneca Nation of Indians in the State of New York...

  1. 24 CFR 203.16 - Certificate and contract regarding use of dwelling for transient or hotel purposes.

    Science.gov (United States)

    2010-04-01

    ... use of dwelling for transient or hotel purposes. 203.16 Section 203.16 Housing and Urban Development... use of dwelling for transient or hotel purposes. Every application filed with respect to insurance of... housing or any part thereof covered by the mortgage for transient or hotel purposes, together with...

  2. 12 CFR Appendix B to Part 203 - Form and Instructions for Data Collection on Ethnicity, Race, and Sex

    Science.gov (United States)

    2010-01-01

    ... Ethnicity, Race, and Sex B Appendix B to Part 203 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF... to Part 203—Form and Instructions for Data Collection on Ethnicity, Race, and Sex I. Instructions on Collection of Data on Ethnicity, Race, and Sex You may list questions regarding the ethnicity, race, and...

  3. 76 FR 30908 - Foreign-Trade Zone 203-Moses Lake, Washington, Export-Only Manufacturing Authority, SGL...

    Science.gov (United States)

    2011-05-27

    ... Foreign-Trade Zones Board Foreign-Trade Zone 203--Moses Lake, Washington, Export-Only Manufacturing..., 2011, an application was submitted by the Port of Moses Lake Public Corporation, grantee of Foreign... manufacture carbon fiber under FTZ procedures solely for export within Site 3 of FTZ 203 in Moses...

  4. 5 CFR 890.203 - Application for approval of, and proposal of amendments to, health benefit plans.

    Science.gov (United States)

    2010-01-01

    ... marketing purposes; (iii) Health care delivery system: A health care delivery system providing reasonable... of amendments to, health benefit plans. 890.203 Section 890.203 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES HEALTH...

  5. 75 FR 59688 - Foreign-Trade Zone 203-Moses Lake, WA; Application for Reorganization and Expansion Under...

    Science.gov (United States)

    2010-09-28

    ... FR 1170, 1/12/09; correction 74 FR 3987, 1/22/09). The ASF is an option for grantees for the... 203 was approved by the Board on October 18, 1994 (Board Order 702, 59 FR 54433, 10/31/94). The... Foreign-Trade Zones Board Foreign-Trade Zone 203--Moses Lake, WA; Application for Reorganization...

  6. miR-203 inhibits cell proliferation and promotes cisplatin induced cell death in tongue squamous cancer.

    Science.gov (United States)

    Lin, Jiong; Lin, Yao; Fan, Li; Kuang, Wei; Zheng, Liwei; Wu, Jiahua; Shang, Peng; Wang, Qiaofeng; Tan, Jiali

    2016-04-29

    Oral squamous cell carcinoma (OSCC) is one of the most common types of the head and neck cancer. Chemo resistance of OSCC has been identified as a substantial therapeutic hurdle. In this study, we analyzed the role of miR-203 in the OSCC and its effects on cisplatin-induced cell death in an OSCC cell line, Tca8113. There was a significant decrease of miR-203 expression in OSCC samples, compared with the adjacent normal, non-cancerous tissue. After 3 days cisplatin treatment, the survived Tca8113 cells had a lower expression of miR-203 than that in the untreated control group. In contrast, PIK3CA showed an inverse expression in cancer and cisplatin survived Tca8113 cells. Transfection of Tca8113 cells with miR-203 mimics greatly reduced PIK3CA expression and Akt activation. Furthermore, miR-203 repressed PIK3CA expression through targeting the 3'UTR. Restoration of miR-203 not only suppressed cell proliferation, but also sensitized cells to cisplatin induced cell apoptosis. This effect was absent in cells that were simultaneously treated with PIK3CA RNAi. In summary, these findings suggest miR-203 plays an important role in cisplatin resistance in OSCC, and furthermore delivery of miR-203 analogs may serve as an adjuvant therapy for OSCC.

  7. 12 CFR 347.203 - Deposit insurance required for all branches of foreign banks engaged in domestic retail deposit...

    Science.gov (United States)

    2010-01-01

    ... foreign banks engaged in domestic retail deposit activity in the same State. 347.203 Section 347.203 Banks... engaged in domestic retail deposit activity in the same State. The FDIC will not insure deposits in any... foreign bank in the same state that engages in domestic retail deposit activity will be an insured branch....

  8. 胃癌患者外周血microRNA-203的检测及意义

    Institute of Scientific and Technical Information of China (English)

    邵文

    2012-01-01

    目的探讨胃癌患者外周血microRNA-203的表达及临床意义。方法采用RT—PCR方法检测20例胃癌患者、10例健康志愿者外周血中microRNA-203的表达。结果胃癌组和正常对照组外周血中microRNA-203的表达有显著差异(P〈0.01)。胃癌组外周血中microRNA-203的表达水平较正常对照组明显下调。结论外周血中microRNA-203的检测可作为胃癌早期诊断的标志物。

  9. 胃癌患者外周血microRNA-203的检测及意义

    Institute of Scientific and Technical Information of China (English)

    邵文

    2012-01-01

    目的 探讨胃癌患者外周血microRNA-203的表达及临床意义.方法 采用RT-PCR方法检测20例胃癌患者、10例健康志愿者外周血中microRNA-203的表达.结果 胃癌组和正常对照组外周血中microRNA-203的表达有显著差异(P<0.01).胃癌组外周血中microRNA-203的表达水平较正常对照组明显下调.结论 外周血中microRNA-203的检测可作为胃癌早期诊断的标志物.

  10. Rewiring of an Epithelial Differentiation Factor, miR-203, to Inhibit Human Squamous Cell Carcinoma Metastasis

    Directory of Open Access Journals (Sweden)

    Nathan Benaich

    2014-10-01

    Full Text Available Metastatic colonization of distant organs underpins the majority of human-cancer-related deaths, including deaths from head and neck squamous cell carcinoma (HNSCC. We report that miR-203, a miRNA that triggers differentiation in multilayered epithelia, inhibits multiple postextravasation events during HNSCC lung metastasis. Inducible reactivation of miR-203 in already established lung metastases reduces the overall metastatic burden. Using an integrated approach, we reveal that miR-203 inhibits metastasis independently of its effects on differentiation. In vivo genetic reconstitution experiments show that miR-203 inhibits lung metastasis by suppressing the prometastatic activities of three factors involved in cytoskeletal dynamics (LASP1, extracellular matrix remodeling (SPARC, and cell metabolism (NUAK1. Expression of miR-203 and its downstream effectors correlates with HNSCC overall survival outcomes, indicating the therapeutic potential of targeting this signaling axis.

  11. Effect of vitamin D on the intestinal absorption of /sup 203/Pb and /sup 47/Ca in chicks

    Energy Technology Data Exchange (ETDEWEB)

    Mykkaenen, H.M.; Wasserman, R.H.

    1982-03-01

    The transfer of /sup 203/Pb and/or /sup 47/Ca across the intestinal epithelium of the chick was investigated, with emphasis given to the functional role of cholecalciferol (vitamin D-3). /sup 203/Pb, after introduction in the intestinal lumen, is rapidly accumulated by the intestinal tissue, and only a fraction of /sup 203/ Pb is translocated parenterally (absorbed). Cholecalciferol did not significantly affect the accumulation of /sup 203/Pb by intestinal tissue but did accelerate /sup 203/Pb movement across the basal-lateral membrane. In contrast, cholecalciferol both decreased /sup 47/Ca tissue levels and increased /sup 47/Ca absorption. In rachitic chicks, the rate of absorption of /sup 203/Pb was greater in the distal than in the proximal segments of the intestine; after cholecalciferol repletion, the degree of absorption in all segments was similar, indicating the order of cholecalciferol effectiveness as duodenum greater than or equal to jejunum > ileum. An acute dose of 1,25(OH)/sub 2/D/sub 3/ to rachitic chicks also enhanced both /sup 203/Pb and /sup 47/Ca absorption, but the time course and pattern of absorption of these metal cations differed. The time at which the absorption of /sup 203/Pb peaked and returned to base-line occurred sooner than for /sup 47/Ca. Also the back-flux (blood ..-->.. intestinal lumen) of /sup 47/Ca was enhanced by cholecalciferol, whereas no effect on the back-flux of /sup 203/Pb was noted. These studies show that cholecalciferol and 1,25(OH)/sub 2/D/sub 3/ affects both the /sup 203/Pb and /sup 47/Ca absorptive processes, but the nature of these responses are not identical, suggesting differences in the transport path or the macromolecular interactions of these metal ions during the course of absorption, or both.

  12. 30 CFR 203.55 - Under what conditions can my end-of-life royalty relief arrangement for an oil and gas lease be...

    Science.gov (United States)

    2010-07-01

    ... royalty relief arrangement for an oil and gas lease be ended? 203.55 Section 203.55 Mineral Resources... ROYALTY RATES OCS Oil, Gas, and Sulfur General Royalty Relief for End-Of-Life Leases § 203.55 Under what conditions can my end-of-life royalty relief arrangement for an oil and gas lease be ended? (a) If you...

  13. 7 CFR 1744.203 - Establishing amount of rural development investment.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Establishing amount of rural development investment... INSURED TELEPHONE LOANS Borrower Investments § 1744.203 Establishing amount of rural development investment. For purposes of determining whether a rural development investment is within the limits of...

  14. 33 CFR 203.43 - Inspection of Federal flood control works.

    Science.gov (United States)

    2010-07-01

    ... accordance with 33 CFR 208.10 and Engineer Regulation (ER) 1130-2-530, Flood Control Operations and... PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program § 203.43 Inspection of Federal flood control works. (a)...

  15. 33 CFR 203.45 - Rehabilitation of Federal flood control works.

    Science.gov (United States)

    2010-07-01

    ... PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program § 203.45 Rehabilitation of Federal flood control works. Rehabilitation of Federal flood control projects will be identical to rehabilitation of non-Federal projects (§...

  16. 33 CFR 203.85 - Rehabilitation of Federal flood control projects.

    Science.gov (United States)

    2010-07-01

    ... PROCEDURES Local Interests/Cooperation Agreements § 203.85 Rehabilitation of Federal flood control projects. Some sponsors of Federal flood control projects are not required to furnish written assurances of local... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Rehabilitation of Federal...

  17. 33 CFR 203.42 - Inspection of non-Federal flood control works.

    Science.gov (United States)

    2010-07-01

    ... PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program § 203.42 Inspection of non-Federal flood control works. (a) Required inspections. The Corps will conduct inspections of non-Federal flood control works. These inspections are...

  18. 42 CFR 50.203 - Sterilization of a mentally competent individual aged 21 or older.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Sterilization of a mentally competent individual... HUMAN SERVICES GRANTS POLICIES OF GENERAL APPLICABILITY Sterilization of Persons in Federally Assisted Family Planning Projects § 50.203 Sterilization of a mentally competent individual aged 21 or...

  19. 24 CFR 972.203 - Definition of “conversion.”

    Science.gov (United States)

    2010-04-01

    ... DEVELOPMENT CONVERSION OF PUBLIC HOUSING TO TENANT-BASED ASSISTANCE Voluntary Conversion of Public Housing Developments Purpose; Definition of Conversion § 972.203 Definition of “conversion.” For purposes of this subpart, the term “conversion” means the removal of public housing units from the inventory of a...

  20. 24 CFR 203.430 - Sale of interests in insured mortgages.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Sale, Assignment and Pledge of Insured Mortgage § 203.430 Sale of interests in insured mortgages. No mortgagee may sell or...

  1. 24 CFR 203.404 - Amount of payment-assigned mortgages.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Payment of Insurance Benefits § 203.404 Amount of payment—assigned mortgages. Upon an acceptable assignment of a mortgage,...

  2. 24 CFR 203.436 - Claim procedure-graduated payment mortgages.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Graduated Payment Mortgages § 203... principal or interest. (b) The phrases unpaid principal balance of the loan or principal of the...

  3. 10 CFR 9.203 - Procedure where response to demand is required prior to receiving instructions.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Procedure where response to demand is required prior to... or Disclosure in Response to Subpoenas or Demands of Courts or Other Authorities § 9.203 Procedure where response to demand is required prior to receiving instructions. If a response to the demand...

  4. 6 CFR 27.203 - Calculating the screening threshold quantity by security issue.

    Science.gov (United States)

    2010-01-01

    ... Act, 42 U.S.C. 6901 et. seq., except for the waste described in 40 CFR 261.33; (8) in naturally... SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Chemical Facility Security Program § 27.203 Calculating... either as compressed air or as part of combustion; (6) Contained in articles, as defined in 40 CFR...

  5. 30 CFR 203.85 - What is in an economic viability and relief justification report?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What is in an economic viability and relief... Required Reports § 203.85 What is in an economic viability and relief justification report? This report... economic viability and relief justification report must contain the following items for an oil and...

  6. 30 CFR 203.82 - What is MMS's authority to collect this information?

    Science.gov (United States)

    2010-07-01

    ... Reports § 203.82 What is MMS's authority to collect this information? The Office of Management and Budget... determinations. (1) Your application for royalty relief must contain enough information on finances, economics...-production development reports must contain enough information for us to verify that your...

  7. 17 CFR 275.203-2 - Withdrawal from investment adviser registration.

    Science.gov (United States)

    2010-04-01

    ... application). (b) Electronic filing. Once you have filed your Form ADV (17 CFR 279.1) (or any amendments to... Withdrawal from investment adviser registration. (a) Form ADV-W. You must file Form ADV-W (17 CFR 279.2) to... days after acceptance solely for the purpose of commencing a proceeding under section 203(e) of the...

  8. 24 CFR 203.204 - Requirements and limitations of a plan.

    Science.gov (United States)

    2010-04-01

    ... structural defect claim, Plans must, unless prohibited by applicable law, provide for binding arbitration... time of settlement. In the case of optional coverage beyond the coverage required under § 203.205, the... protection measures. (f) Unless prohibited by applicable law, Plans must, at a minimum, stipulate that...

  9. 24 CFR 203.319 - Pro rata payment of premiums and charges.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Pro rata payment of premiums and... § 203.319 Pro rata payment of premiums and charges. No contract of insurance shall be terminated until the mortgagee has paid to the Commissioner the pro rata portion of the current annual MIP or...

  10. 24 CFR 203.268 - Pro rata payment of periodic MIP.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Pro rata payment of periodic MIP...-Periodic Payment § 203.268 Pro rata payment of periodic MIP. (a) If the insurance contract is terminated... rata MIP shall not be due or payable where the mortgagee notifies the Commissioner that foreclosure...

  11. 29 CFR 780.203 - Performance of operations on a farm but not by the farmer.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Performance of operations on a farm but not by the farmer... Operations § 780.203 Performance of operations on a farm but not by the farmer. Logging or sawmill operations on a farm undertaken on behalf of the farmer or on behalf of the buyer of the logs or the...

  12. 76 FR 1599 - Foreign-Trade Zone 203-Moses Lake, Washington; Application for Manufacturing Authority, SGL...

    Science.gov (United States)

    2011-01-11

    ... Foreign-Trade Zones Board Foreign-Trade Zone 203--Moses Lake, Washington; Application for Manufacturing Authority, SGL Automotive Carbon Fibers, LLC, (Carbon Fiber Manufacturing), Moses Lake, WA An application... Carbon Fibers, LLC (SGL Automotive), located in Moses Lake, Washington. The application was...

  13. 20 CFR 718.203 - Establishing relationship of pneumoconiosis to coal mine employment.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Establishing relationship of pneumoconiosis... DETERMINING COAL MINERS' TOTAL DISABILITY OR DEATH DUE TO PNEUMOCONIOSIS Determining Entitlement to Benefits § 718.203 Establishing relationship of pneumoconiosis to coal mine employment. (a) In order for...

  14. 21 CFR 203.60 - Request and receipt forms, reports, and records.

    Science.gov (United States)

    2010-04-01

    ... SERVICES (CONTINUED) DRUGS: GENERAL PRESCRIPTION DRUG MARKETING Request and Receipt Forms, Reports, and Records § 203.60 Request and receipt forms, reports, and records. (a) Use of electronic records, electronic signatures, and handwritten signatures executed to electronic records. (1) Provided...

  15. 31 CFR 537.203 - Prohibited importation of products of Burma.

    Science.gov (United States)

    2010-07-01

    ...: Section 3(b) of the Burmese Freedom and Democracy Act of 2003 provides that the prohibition contained in... Prohibitions § 537.203 Prohibited importation of products of Burma. Except as otherwise authorized, and... President determines and notifies specified committees of Congress that to do so is in the national...

  16. 23 CFR 633.203 - Applicability of existing laws, regulations, and directives.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Applicability of existing laws, regulations, and...) § 633.203 Applicability of existing laws, regulations, and directives. The provisions of title 23 U.S.C..., respectively, to the development highway system and the local access roads. In addition, the Regulations...

  17. A catalog of 203 galaxy clusters serendipitously detected in the ROSAT PSPC pointed observations

    DEFF Research Database (Denmark)

    Vikhlinin, A.; McNamara, B.R.; Forman, W.;

    1998-01-01

    We present a catalog of 203 clusters of galaxies serendipitously detected in 647 ROSAT PSPC high Galactic latitude pointings covering 158 deg(2). This is one of the largest X-ray-selected cluster samples, comparable in size only to the ROSAT All-Sky Survey sample of nearby clusters (Ebeling et al...

  18. Revised final report for tank 241-C-203, auger samples 95-AUG-20 and 95-AUG-21. Revision 1

    International Nuclear Information System (INIS)

    Two auger samples from tank 241-C-203 (C-203) were received at the 222-S Laboratories and underwent safety screening analyses, consisting of differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and total alpha activity. No notification limits were exceeded for the analyses. Two samples were submitted for a density determination at the request of Characterization Plant Engineering. SCOPE This document is the revised final report for the tank C-203 auger samples collected on April 5, 1995 (samples 95-AUG-20 and 95-AUG-021)

  19. Use of CYBER 203 and CYBER 205 computers for three-dimensional transonic flow calculations

    Science.gov (United States)

    Melson, N. D.; Keller, J. D.

    1983-04-01

    Experiences are discussed for modifying two three-dimensional transonic flow computer programs (FLO 22 and FLO 27) for use on the CDC CYBER 203 computer system. Both programs were originally written for use on serial machines. Several methods were attempted to optimize the execution of the two programs on the vector machine: leaving the program in a scalar form (i.e., serial computation) with compiler software used to optimize and vectorize the program, vectorizing parts of the existing algorithm in the program, and incorporating a vectorizable algorithm (ZEBRA I or ZEBRA II) in the program. Comparison runs of the programs were made on CDC CYBER 175. CYBER 203, and two pipe CDC CYBER 205 computer systems.

  20. Pump-limited, 203 W, single-frequency monolithic fiber amplifier based on laser gain competition.

    Science.gov (United States)

    Zeringue, Clint; Vergien, Christopher; Dajani, Iyad

    2011-03-01

    We present high power results of a Yb-doped fiber amplifier seeded with a combination of broad and single-frequency laser signals. This two-tone concept was used in conjunction with externally applied or intrinsically formed thermal gradients to demonstrate combined stimulated Brillouin scattering suppression in a copumped monolithic, polarization-maintaining (PM) fiber. Depending on the input parameters and the thermal gradient, the output power of the single-frequency signal ranged from 80 to 203 W with slope efficiencies from 70% to 80%. The 203 W amplifier was pump limited and is, to the best of our knowledge, the highest reported in the literature for monolithic, PM single-frequency fiber amplifiers. PMID:21368926

  1. HPLC determination of brain biogenic amines following treatment with bispyridinium aldoxime K203.

    Science.gov (United States)

    Hashemi, F; Laufer, R; Szegi, P; Csomor, V; Kalász, H; Tekes, Kornélia

    2014-03-01

    Effect of a new acetylcholine-esterase reactivator, K203 as a new potential antidote in organophosphate intoxications was studied on dopamine (DA), homovanillic acid (HVA), serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) levels in seven brain regions (cerebellum, spinal cord, hippocampus, hypothalamus, striatum, medulla oblongata and frontal cortex) of rats by an optimized and validated HPLC method. No significant change in brain level of these neurotransmitters was found either 15 or 60 min following treatment. However, when 5-HIAA/5-HT ratios were calculated as measure of turnover, significant decreases were found in the cerebellum, hippocampus, hypothalamus and the frontal cortex 15 min following K203 administration, but after 60 min only in the frontal cortex. PMID:24631794

  2. Development of a new radiolabel (lead-203) and new chelating agents for labeling monoclonal anntibodies for imaging

    Energy Technology Data Exchange (ETDEWEB)

    Srivastava, S.C.; Mease, R.C.; Meinken, G.E.; Mausner, L.F.; Steplewski, Z.

    1988-01-01

    High liver uptake and slow body clearance presently limit the usefulness of /sup 111/In labeled antibodies for tumor imaging. We have investigated /sup 203/Pb as an alternate and better antibody label. The DTPA and cyclohexyl EDTA (CDTA) conjugates of an anticolon carcinoma antibody, 17-1A were labeled (bicyclic anhydride method) with /sup 203/Pb and /sup 111/In with 60 and 90% labeling yields, respectively. The biodistribution of /sup 203/Pb-17-1A conjugates was compared with the corresponding /sup 111/In-labeled preparations and with /sup 203/Pb-DTPA, /sup 203/Pb-nitrate and nonrelevant antibody controls in normal and human tumor (SW948) xenografted nude mice at 24, and 96 hr. Lead-203-labeled CDTA and DTPA antibody conjugates gave similar in vivo distributions. Even though the lead bound to these chelate-antibody conjugates was more labile in serum and in vivo, compared to indium, it cleared much faster from the liver and the whole body. A new series of chelating agents based on the incorporation of a trans-1,2- diaminocyclohexane moiety into the carbon backbone of polyaminocarboxylates is being synthesized. These are expected to provide stronger complexing ability for lead and produce greater in vivo stability. These ligands are also expected to be superior to EDTA and DTPA for labeling antibodies with other radiometals, including indium. 32 refs., 3 tabs.

  3. Tank 241-T-203, core 190 analytical results for the final report

    Energy Technology Data Exchange (ETDEWEB)

    Steen, F.H.

    1997-08-05

    This document is the analytical laboratory report for tank 241-T-203 push mode core segments collected on April 17, 1997 and April 18, 1997. The segments were subsainpled and analyzed in accordance with the Tank 241-T-203 Push Mode Core Sampling andanalysis Plan (TSAP) (Schreiber, 1997a), the Safety Screening Data Quality Objective (DQO)(Dukelow, et al., 1995) and Leffer oflnstructionfor Core Sample Analysis of Tanks 241-T-201, 241-T-202, 241-T-203, and 241-T-204 (LOI)(Hall, 1997). The analytical results are included in the data summary report (Table 1). None of the samples submitted for Differential Scanning Calorimetry (DSC), Total Alpha Activity (AT) and Total Organic Carbon (TOC) exceeded notification limits as stated in the TSAP (Schreiber, 1997a). The statistical results of the 95% confidence interval on the mean calculations are provided by the Tank Waste Remediation Systems (TWRS) Technical Basis Group in accordance with the Memorandum of Understanding (Schreiber, 1997b) and not considered in this report.

  4. Microanalysis of oligosaccharide HS203 in beagle dog plasma by postcolumn fluorescence derivatization method.

    Science.gov (United States)

    Sun, Shumeng; Zhao, Xia; Li, Guangsheng; Yu, Guangli; Xing, Xiaoxu; Zeng, Yangyang; Wu, Jian; Wang, Jianing

    2012-06-20

    A rapid and sensitive postcolumn fluorescence derivatization method was developed for microanalysis of antidiabetic oligosaccharide HS203 in beagle dog plasma. After plasma protein was removed by a simple and fast ultrafiltration method, chromatographic separation was performed on an Asahipak GS-320 HQ column with a mobile phase of 50 mmol/L phosphate buffer (pH 6.7) and acetonitrile (83/17, v/v). The column effluent was monitored by fluorescence detection at 249 nm (excitation) and 435 nm (emission) using guanidine hydrochloride as a postcolumn derivatizing reagent. A satisfactory resolution of the analyte was achieved and the limit of detection was found to be 4 ng (more sensitive than silver staining of HS203 in polyacrylamide gel electrophoresis). The method described above was successfully applied to a pharmacokinetic study of HS203 and to monitor blood glucose level simultaneously in beagle dog. It is also possible to be applied for microanalysis of other oligosaccharides in biological samples. PMID:24750771

  5. The expression and clinical significance of miR-203 in pediatric acute leukemia%miR-203在儿童急性白血病患者中的表达及其临床意义

    Institute of Scientific and Technical Information of China (English)

    王娜; 潘健; 曹岚; 卢俊; 肖佩芳; 赵文理; 胡绍燕; 柴忆欢

    2013-01-01

    目的 检测miR-203在儿童急性白血病患者中的甲基化状态及表达情况,探讨其临床意义.方法 应用甲基化特异性聚合酶链反应检测miR-203启动子区CpG岛的甲基化状态,用实时荧光定量聚合酶链反应检测miR-203的相对表达量,分析其与临床指标间的关系.结果 31例儿童急性淋巴细胞白血病(ALL)、15例儿童急性髓系白血病(AML)及23份非恶性血液病患儿骨髓标本(对照组)均未检测到miR-203的甲基化现象.miR-203在对照组、儿童急性白血病组、ALL组及AML组的相对表达量分别为16.93±6.31、48.97±10.38、55.88±12.91、24.28±9.10,儿童急性白血病组、ALL组与对照组相比,差异有统计学意义(P值分别为0.011和0.009),儿童AML组与对照组相比,差异无统计学意义(P=0.514).各项临床指标中,miR-203的表达与初诊ALL患儿的性别、免疫分型、染色体核型、是否检出融合基因、BCR-ABL基因表达、SIL-TAL1基因表达、泼尼松试验及急性白血病患儿的性别、染色体核型、是否检出融合基因、SIL-TAL1基因表达相关(P值均<0.05).其中在ALL危险度分组两两比较中,中危组与高危组两组间miR-203的表达差异有统计学意义(P=0.022).结论 miR-203在大部分急性白血病患儿中不受甲基化机制调控.miR-203可能作为原癌基因参与儿童急性白血病尤其是ALL的形成.miR-203的高表达可能与急性白血病患儿尤其是ALL患儿的不良预后相关.%Objective To investigate the methylation,expression and clinical significance of miR-203 in pediatric acute leukemia.Methods The methylation status of miR-203 promoter CpG islands was detected with methylation-specific polymerase chain reaction.The expression of miR-203 was detected by Taqman real-time quantitative polymerase chain reaction.And the clinical significance of miR-203 in pediatric acute leukemia (ALL) was also analyzed.Results The promoter of miR-203 was unmethylated in all of 31

  6. Production and radiochemical separation of 203Pb radioisotope for nuclear medicine

    International Nuclear Information System (INIS)

    Complete text of publication follows. The heavy metal pollution due to their industrial production, waste repository or accident as the cyanide spill in river Tisza in 2002, increase the scientific interest for using an ideal trace isotope for monitoring these type of events. The lead is one of the most toxic and commonly used heavy metal, its poisoning is often deadly because very difficult to recognize and identify. The neuro-scientific study of biodegradation effect of lead could be an impressive scientific field of application of 203Pb radioisotope. However the targeted radionuclide therapy especially the α-emitting radioisotope therapy is also strongly interested to find an ideal tracer for the 213Bi and 212Pb therapy. Therefore the 203Pb is a potential radioisotope for this role due to its radiation behaviour and as heavy metal element. The 203Tl(p,n) 203Pb nuclear reaction was chosen for the production. The irradiation was done at the compact cyclotron of Atomki with proton beam 14.5 MeV energy and beam current of 7 μAs. The thickness of the target material was 840 μm, the irradiation time was 3 hours and the produced activity was 40 MBq at EOB. It corresponds to 1.87 MBq/μAh physical yield of the reaction which correlating with the cross section curve. A new technique was developed for target preparation. The metal Tl was pressed into a copper backing and covered with a HAWAR foil with thickness of 11 μm. The covering foil saved the surface of the Tl from the oxidation and also transferred the dissipating heat to the cooling He gas. The back side of the target was cooled with pressured cold water. The irradiated Tl target was pressed out from the copper backing, which had only the thickness of 0.2 mm. Then the Thallium was dissolved in nitric acid. The excess acid was evaporated slowly. The nitrate form was transferred to chloride form by 8 mol/dm 3 HCl and the Thallium was kept in 3+ oxidation stage by hydrogen peroxide. The separation was carried out

  7. Down regulation of miR-203 in radiation-induced thymic lymphoma promoted cells proliferation and inhibited apoptosis%Down regulation of miR-203in radiation-induced thymic lymphoma promoted cells proliferation and inhibited apoptosis

    Institute of Scientific and Technical Information of China (English)

    Zhang Chaoxiong; Zhang Mingjian; Gao Fu; Zhou Chuanfeng; Zhang Pei; Cai Jianming; Liu Cong

    2015-01-01

    Objective To investigate the role of miR-203 in radiation-induced thymic lymphoma (RITL).Methods A 60Co irradiator was used for total-body irradiation.MicroRNAs(miRNAs) level was assayed by qRT-PCR.Cell proliferation was assayed by MTT assay.Cell apoptosis was examined by fluorescence activated cell sorter (FACS).Dual luciferase reporter assay system was used to detect the 3'UTR reporter.Results MiR-203 was down-regulated in RITL tissues.Overexpression of miR-203 strongly inhibited the proliferation of both NIH3T3 cells and EL4 cells and vice versa.MiR-203 inhibited cells proliferation and induced apoptosis via TANK-binding kinase (TBK1),SLUG (SNAI2) and Cyclin D1 (CCND1).Conclusions Radiation down-regulated the level of miR-203 in thymic,which promoted radiation-induced thymic lymphoma by targeting TBK1,SNAI2 and CCND1.

  8. Ovarian masses in children and adolescents in China: analysis of 203 cases

    OpenAIRE

    Liu, Hongqian; Wang, Xiangao; Lu, Donghao; Liu, Zhihong; Shi, Gang

    2013-01-01

    Objective The true incidence of ovarian tumors in children is unknown. Few studies beyond case reports and case series have been published concerning pediatric ovarian tumors. Herein we review a large number of ovarian tumor cases. Methods The charts of 203 patients who presented with adnexal masses were reviewed. Results The patient’s ranged in age from 2 to 18 years (mean = 15.6 years), with 30 being premenarchal (14.8%). The incidence of ovarian tumor increases with age, especially in pati...

  9. Residual Waste from Hanford Tanks 241-C-203 and 241-C-204. 2. Contaminant Release Model

    International Nuclear Information System (INIS)

    Fusion analyses, water leaches, selective extractions, empirical solubility measurements, and thermodynamic modeling were used with results from solid-phase characterization studies [see companion paper (1)] to determine total concentrations, contaminant-phase associations, and develop contaminant release models for residual sludge from single-shell underground waste tanks 241-C-203 and 241-C-204 at the U.S. Department of Energy?s Hanford Site in southeastern Washington state. U and Tc are primary contaminants of concern because of their long half-lives and their generally high mobility in oxidizing soil and groundwater environments. Uranium release was determined to be controlled by two phases; ?ejkaite [Na4(UO2)(CO3)3] and poorly crystalline Na2U2O7 [or clarkeite Na[(UO2)O(OH)](H2O)0-1] which were identified in C-203 and C-204 sludge samples (1). U release was determined to occur in three stages from these phases. In the first stage, U release will be controlled by the solubility of ?ejkaite, which is suppressed by high concentrations of sodium released from dissolution of NaNO3 in the residual sludges. Equilibrium solubility calculations indicate the U released during this stage will have a maximum concentration of 0.021 M. When all the NaNO3 has dissolved from the sludge, the solubility of the remaining ?ejkaite will increase to 0.28 M. After ?ejkaite has completely dissolved, the maximum concentration of U released is expected to be controlled by the solubility of Na2U2O7 at a concentration of 3.0 ? 10-5 M. For Tc, a significant fraction of its concentration in the residual sludge was determined to be relatively insoluble (20 wt% for C-203 and 80 wt% for C-204). Because of the low concentrations of Tc in these sludge materials, the characterization studies did not identify any discrete Tc solids phases. Therefore, release of the readily soluble fraction of Tc was assumed to be controlled by the solubility of NaTcO4 at 7.1 M. Selective extraction results

  10. 30 CFR 203.32 - What other requirements or restrictions apply to royalty relief for a qualified phase 2 or phase...

    Science.gov (United States)

    2010-07-01

    ... REDUCTION IN ROYALTY RATES OCS Oil, Gas, and Sulfur General Royalty Relief for Drilling Ultra-Deep Wells on... qualified ultra-deep well is a directional well (either an original well or a sidetrack) drilled across a... to royalty relief for a qualified phase 2 or phase 3 ultra-deep well? 203.32 Section 203.32...

  11. 30 CFR 203.40 - Which leases are eligible for royalty relief as a result of drilling a deep well or a phase 1...

    Science.gov (United States)

    2010-07-01

    ... REDUCTION IN ROYALTY RATES OCS Oil, Gas, and Sulfur General Royalty Relief for Drilling Deep Gas Wells on... a result of drilling a deep well or a phase 1 ultra-deep well? 203.40 Section 203.40 Mineral... a result of drilling a deep well or a phase 1 ultra-deep well? Your lease may receive an RSV...

  12. 30 CFR 203.30 - Which leases are eligible for royalty relief as a result of drilling a phase 2 or phase 3 ultra...

    Science.gov (United States)

    2010-07-01

    ... ROYALTY RATES OCS Oil, Gas, and Sulfur General Royalty Relief for Drilling Ultra-Deep Wells on Leases Not... a result of drilling a phase 2 or phase 3 ultra-deep well? 203.30 Section 203.30 Mineral Resources... drilling a phase 2 or phase 3 ultra-deep well? Your lease may receive a royalty suspension volume...

  13. 30 CFR 203.34 - To which production may an RSV earned by qualified phase 2 and phase 3 ultra-deep wells on my...

    Science.gov (United States)

    2010-07-01

    ... REDUCTION IN ROYALTY RATES OCS Oil, Gas, and Sulfur General Royalty Relief for Drilling Ultra-Deep Wells on...) To production from a deep well or ultra-deep well that commenced drilling before: (1) March 26, 2003... qualified phase 2 and phase 3 ultra-deep wells on my lease not be applied? 203.34 Section 203.34...

  14. 24 CFR 257.203 - Calculation of up-front and annual mortgage insurance premiums for H4H program mortgages.

    Science.gov (United States)

    2010-04-01

    ... mortgage insurance premiums for H4H program mortgages. 257.203 Section 257.203 Housing and Urban... FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND... mortgage insurance premiums for H4H program mortgages. (a) Applicable premiums. Any mortgage presented...

  15. 20 CFR 25.203 - How is the Special Schedule applied to non-resident aliens in the Territory of Guam?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false How is the Special Schedule applied to non-resident aliens in the Territory of Guam? 25.203 Section 25.203 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL EMPLOYEES' COMPENSATION ACT COMPENSATION FOR DISABILITY AND DEATH OF NONCITIZEN FEDERAL...

  16. 25 CFR 162.203 - When can the regulations in this subpart be superseded or modified by tribal laws and leasing...

    Science.gov (United States)

    2010-04-01

    ... modified by tribal laws and leasing policies? 162.203 Section 162.203 Indians BUREAU OF INDIAN AFFAIRS... When can the regulations in this subpart be superseded or modified by tribal laws and leasing policies... resolution establishing a general policy for the leasing of tribal and individually-owned agricultural...

  17. Protection from endotoxic shock by EVK-203, a novel alkylpolyamine sequestrant of lipopolysaccharide.

    Science.gov (United States)

    Nguyen, Thuan B; Adisechan, Ashok Kumar; Suresh Kumar, E V K; Balakrishna, Rajalakshmi; Kimbrell, Matthew R; Miller, Kelly A; Datta, Apurba; David, Sunil A

    2007-09-01

    Lipopolysaccharides (LPS) play a key role in the pathogenesis of septic shock, a major cause of mortality in the critically ill patient. The only therapeutic option aimed at limiting downstream systemic inflammatory processes by targeting lipopolysaccharide is Toraymyxin, an extracorporeal hemoperfusion device using solid phase-immobilized polymyxin B (PMB). While PMB is known to effectively sequester LPS, its severe systemic toxicity proscribes its parenteral use, and hemoperfusion may not be feasible in patients in shock. In our continuing efforts to develop small-molecule mimics which display the LPS-sequestering properties, but not the toxicity of PMB, a series of mono- and bis-substituted dialkylpolyamines were synthesized and evaluated. We show that EVK-203, an alkylpolyamine compound, specifically binds to and neutralizes the activity of LPS, and affords complete protection in a murine model of endotoxic shock. EVK-203 is without any apparent toxicity when administered to mice at multiples of therapeutic doses for several days. The specific endotoxin-sequestering property along with a very favorable therapeutic index renders this compound an ideal candidate for preclinical development.

  18. 48 CFR 203.104-4 - Disclosure, protection, and marking of contractor bid or proposal information and source...

    Science.gov (United States)

    2010-10-01

    ..., and marking of contractor bid or proposal information and source selection information. 203.104-4....104-4 Disclosure, protection, and marking of contractor bid or proposal information and source selection information. (d)(3) For purposes of FAR 3.104-4(d)(3) only, DoD follows the...

  19. 42 CFR 413.203 - Transplant center costs for organs sent to foreign countries or transplanted in patients other...

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Transplant center costs for organs sent to foreign...) Services and Organ Procurement Costs § 413.203 Transplant center costs for organs sent to foreign countries... for all organs is reduced by the costs associated with procuring organs sent to foreign...

  20. 49 CFR 1572.203 - Transportation of explosives from Canada to the United States via railroad carrier.

    Science.gov (United States)

    2010-10-01

    ... doing business in Canada and will also determine whether the train crew members present no known... Hazardous Materials From Canada or Mexico To and Within the United States by Land Modes § 1572.203... Safety, Research and Special Programs Administration, in accordance with 49 CFR 173.56, and determined...

  1. Activation analysis of thallium in urine using the 203Tl(n,2n) 202Tl reaction

    International Nuclear Information System (INIS)

    The method developed by the authors of thallium determination in human urine, based on the 203Tl(n,2n)202Tl reaction followed by chemical separation and measurement of the produced 202Tl by gamma spectrometry, is described. Its application in some cases of intoxication by thallium is reported. The advantages and limitations of the described technique are discussed. (author)

  2. 42 CFR 137.203 - May a Self-Governance Tribe participate in a voluntary national uniform data collection effort...

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false May a Self-Governance Tribe participate in a... HUMAN SERVICES TRIBAL SELF-GOVERNANCE Operational Provisions Health Status Reports § 137.203 May a Self-Governance Tribe participate in a voluntary national uniform data collection effort with the IHS? Yes,...

  3. 78 FR 56655 - Foreign-Trade Zone (FTZ) 203-Moses Lake, Washington; Notification of Proposed Production Activity...

    Science.gov (United States)

    2013-09-13

    ... Foreign-Trade Zones Board Foreign-Trade Zone (FTZ) 203--Moses Lake, Washington; Notification of Proposed Production Activity; AREVA Inc. (Fuel Rod Assemblies); Richland, Washington The Moses Lake Public Corporation... AREVA Inc. (AREVA), located in Richland, Washington. The notification conforming to the requirements...

  4. Hypersonic characteristics of an advanced aerospace plane at Mach 20.3

    Science.gov (United States)

    Mccandless, R. S.

    1985-01-01

    Wind-tunnel studies have been performed in the Langley Hypersonic Helium Tunnel Facility to obtain static longitudinal and lateral-directional aerodynamic characteristics of an advanced aerospace plane concept. The nominal test conditions are a Mach number of 20.3 and a Reynolds number of 6.8 x 10 to the 6th power per foot at angles of attack from 0 to 25 deg and angles of sideslip of -3 and 0 deg. Stability and control characteristics are obtained for several deflections of the elevators, elevons, and rudder. In addition, a modified canopy is examined. The results indicate that this vehicle is longitudinally stable at angles of attack near the maximum lift-drag ratio. Also, the vehicle is shown to be directionally unstable with positive dihedral effect.

  5. Biodistribution and radiation dosimetry of a positron emission tomographic ligand, {sup 18}F-SP203, to image metabotropic glutamate subtype 5 receptors in humans

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Yasuyuki; Simeon, Fabrice G.; Pike, Victor W.; Innis, Robert B.; Fujita, Masahiro [National Institute of Mental Health, Molecular Imaging Branch, Bethesda, MD (United States); Hatazawa, Jun [Osaka University Graduate School of Medicine, Department of Nuclear Medicine and Tracer Kinetics, Suita, Osaka (Japan); Mozley, P.D. [Merck Research Laboratories, West Point, PA (United States)

    2010-10-15

    A new PET ligand, 3-fluoro-5-(2-(2-{sup 18}F-(fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ({sup 18}F-SP203), is a positron emission tomographic radioligand selective for metabotropic glutamate subtype 5 receptors. The purposes of this study were to estimate the radiation-absorbed doses of {sup 18}F-SP203 in humans and to determine from the distribution of radioactivity in bone structures with various proportions of bone and red marrow whether {sup 18}F-SP203 undergoes defluorination. Whole-body images were acquired for 5 h after injecting {sup 18}F-SP203 in seven healthy humans. Urine was collected at various time points. Radiation-absorbed doses were estimated by the Medical Internal Radiation Dose scheme. After injecting {sup 18}F-SP203, the two organs with highest radiation exposure were urinary bladder wall and gallbladder wall, consistent with both urinary and fecal excretion. In the skeleton, most of the radioactivity was in bone structures that contain red marrow and not in those without red marrow. Although the dose to red marrow (30.9 {mu}Sv/MBq) was unusually high, the effective dose (17.8 {mu}Sv/MBq) of {sup 18}F-SP203 was typical of that of other {sup 18}F radiotracers. {sup 18}F-SP203 causes an effective dose in humans typical of several other {sup 18}F radioligands and undergoes little defluorination. (orig.)

  6. Regulation of Cell Proliferation and Migration by miR-203 via GAS41/miR-10b Axis in Human Glioblastoma Cells

    Science.gov (United States)

    Pal, Dhananjaya; Mukhopadhyay, Debasmita; Ramaiah, M. Janaki; Sarma, Pranjal; Bhadra, Utpal; Bhadra, Manika Pal

    2016-01-01

    Glioma amplified sequence 41(GAS41) is a potent transcription factor that play a crucial role in cell proliferation and survival. In glioblastoma, the expression of GAS41 at both transcriptional and post transcriptional level needs to be tightly maintained in response to cellular signals. Micro RNAs (miRNA) are small non coding RNA that act as important regulators for modulating the expression of various target genes. Studies have shown that several miRNAs play role in the post-transcriptional regulation of GAS41. Here we identified GAS41 as a novel target for endogenous miR-203 and demonstrate an inverse correlation of miR-203 expression with GAS41 in glioma cell lines (HNGC2 and U87). Over expression of miR-203 negatively regulates GAS41 expression in U87 and HNGC2 cell lines. Moreover, miR-203 restrained miR-10b action by suppressing GAS41. GAS41 is essential for repressing p53 in tumor suppressor pathway during cell proliferation. Enforced expression of GAS41 produced contradictory effect on miR-203 but was able to enhance p53 tumor suppressor pathway associated protein. It was also found that miR-203 maintains the stability of p53 as knock down of p53 expression using siRNA resulted in down regulation of pri-miR and mature miR-203 expression. Conversely reconstitution of miR-203 expression induced apoptosis and inhibited migratory property of glioma cells. Taken together, we show that miR-203 is a key negative regulator of GAS41 and acts as tumor suppressor microRNA in glioma. PMID:27467502

  7. 不同栽培方式下香型优质稻渝香203的产量分析%Analysis of High-quality Rice Yuxiang 203 Yields under Different Planting Patterns

    Institute of Scientific and Technical Information of China (English)

    张现伟; 李经勇; 唐永群; 姚雄

    2011-01-01

    [Objective] The aim was to study the yields of Yuxiang203 in different planting patterns, discuss the better planting pattern to obtain the larger yields. [ Method] The differences of yield and its related characters were studied under 4 planting patterns, hand transplanting,machine transplanting, seedling throwing, direct sowing. [Result] The results showed that the yield performances of Yuxiang203 under 4 planting patterns were as follows:hand transplanting > machine transplanting > seedling throwing > direct sowing. [Conclusion] Four planting and cultivation patterns have their respective advantages and disadvantages. Thereinto, hand transplanting' yield is the biggest, but it has the disadvantage of big labor intensity and high planting cost. Machine transplanting and seedling throwing replace hand transplanting gradually.%[目的]研究不同栽培方式下优质稻渝香203的产量差异,探讨挖掘品种的高产潜力的栽培技术.[方法]研究手栽秧、机栽秧、抛秧、直播4种栽培方式下渝香203产量及相关性状的差异.[结果]手栽秧种植方式下产量最高,之后依次为机栽秧、抛秧,直播栽培方式下产量最低.[结论]4种栽培方式有各自的优缺点.其中手栽秧产量水平最高,但其劳动强度大,种植成本高;机插秧和抛秧正逐渐取代手插秧.

  8. 30 CFR 203.60 - Who may apply for royalty relief on a case-by-case basis in deep water in the Gulf of Mexico or...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Who may apply for royalty relief on a case-by-case basis in deep water in the Gulf of Mexico or offshore of Alaska? 203.60 Section 203.60 Mineral... basis in deep water in the Gulf of Mexico or offshore of Alaska? You may apply for royalty relief...

  9. 9 CFR 203.16 - Mailing of checks in payment for livestock purchased for slaughter, for cash and not on credit.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Mailing of checks in payment for livestock purchased for slaughter, for cash and not on credit. 203.16 Section 203.16 Animals and Animal... Stat. 1250 (7 U.S.C. 228b); 7 CFR 2.17, 2.54; 42 FR 35625; Pub. L. 96-511, 94 Stat. 2812 (44...

  10. Effects of Fe203 Nanoparticles on Water Permeability and Strength Assessments of High Strength Self-Compacting Concrete

    Institute of Scientific and Technical Information of China (English)

    Ali Khoshakhlagh; All Nazar; Gholarnreza Khala

    2012-01-01

    In this work, compressive, flexural and split tensile strength together with coefficient of water absorption of high performance self-compacting concrete containing different amount of Fe2Os nanoparticles have been investigated. The strength and the water permeability of the specimens have been improved by adding Fe2Os nanoparticles in the cement paste up to 4.0 wt%. Fe203 nanoparticle as a foreign nucleation site could accelerate C-S-H gel formation as a result of increased crystalline Ca(OH)2 amount especially at the early age of hydration and hence increase the strength of the specimens. In addition, Fe203 nanoparticles are able to act as nanofillers and recover the pore structure of the specimens by decreasing harmful pores to improve the water permeability. Several empirical relations have been presented to predict the flexural and the split tensile strength of the specimens by means of the corresponding compressive strength at a certain age of curing. Accelerated peak appearance in conduction calorimetry tests, more weight loss in thermogravimetric analysis and more rapid appearance of peaks related to hydrated products in X-ray diffraction results indicate that Fe203 nanoparticles up to 4 wt% could improve the mechanical and the physical properties of the specimens.

  11. Hanford Tanks 241-C-203 and 241-C-204: Residual Waste Contaminant Release Model and Supporting Data

    International Nuclear Information System (INIS)

    This report describes the development of release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. Key results from this work are (1) future releases from the tanks of the primary contaminants of concern (99Tc and 238U) can be represented by relatively simple solubility relationships between infiltrating water and solid phases containing the contaminants; and (2) high percentages of technetium-99 in the sludges (20 wt% in C-203 and 75 wt% in C-204) are not readily water leachable, and, in fact, are very recalcitrant. This is similar to results found in related studies of sludges from Tank AY-102. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for the U.S. Department of Energy

  12. Hanford Tanks 241-C-203 and 241 C 204: Residual Waste Contaminant Release Model and Supporting Data

    International Nuclear Information System (INIS)

    This report was revised in May 2007 to correct 90Sr values in Chapter 3. The changes were made on page 3.9, paragraph two and Table 3.10; page 3.16, last paragraph on the page; and Tables 3.21 and 3.31. The rest of the text remains unchanged from the original report issued in October 2004. This report describes the development of release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. Key results from this work are (1) future releases from the tanks of the primary contaminants of concern (99Tc and 238U) can be represented by relatively simple solubility relationships between infiltrating water and solid phases containing the contaminants; and (2) high percentages of technetium-99 in the sludges (20 wt% in C-203 and 75 wt% in C-204) are not readily water leachable, and, in fact, are very recalcitrant. This is similar to results found in related studies of sludges from Tank AY-102. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for the U.S. Department of Energy.

  13. Hanford Tanks 241-C-203 and 241 C 204: Residual Waste Contaminant Release Model and Supporting Data

    Energy Technology Data Exchange (ETDEWEB)

    Deutsch, William J.; Krupka, Kenneth M.; Lindberg, Michael J.; Cantrell, Kirk J.; Brown, Christopher F.; Schaef, Herbert T.

    2007-05-23

    This report was revised in May 2007 to correct 90Sr values in Chapter 3. The changes were made on page 3.9, paragraph two and Table 3.10; page 3.16, last paragraph on the page; and Tables 3.21 and 3.31. The rest of the text remains unchanged from the original report issued in October 2004. This report describes the development of release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. Key results from this work are (1) future releases from the tanks of the primary contaminants of concern (99Tc and 238U) can be represented by relatively simple solubility relationships between infiltrating water and solid phases containing the contaminants; and (2) high percentages of technetium-99 in the sludges (20 wt% in C-203 and 75 wt% in C-204) are not readily water leachable, and, in fact, are very recalcitrant. This is similar to results found in related studies of sludges from Tank AY-102. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for the U.S. Department of Energy.

  14. Maternal-fetal distribution of mercury ( sup 203 Hg) released from dental amalgam fillings

    Energy Technology Data Exchange (ETDEWEB)

    Vimy, M.J.; Takahashi, Y.; Lorscheider, F.L. (Univ. of Calgary, Alberta (Canada))

    1990-04-01

    In humans, the continuous release of Hg vapor from dental amalgam tooth restorations is markedly increased for prolonged periods after chewing. The present study establishes a time-course distribution for amalgam Hg in body tissues of adult and fetal sheep. Under general anesthesia, five pregnant ewes had twelve occlusal amalgam fillings containing radioactive 203Hg placed in teeth at 112 days gestation. Blood, amniotic fluid, feces, and urine specimens were collected at 1- to 3-day intervals for 16 days. From days 16-140 after amalgam placement (16-41 days for fetal lambs), tissue specimens were analyzed for radioactivity, and total Hg concentrations were calculated. Results demonstrate that Hg from dental amalgam will appear in maternal and fetal blood and amniotic fluid within 2 days after placement of amalgam tooth restorations. Excretion of some of this Hg will also commence within 2 days. All tissues examined displayed Hg accumulation. Highest concentrations of Hg from amalgam in the adult occurred in kidney and liver, whereas in the fetus the highest amalgam Hg concentrations appeared in liver and pituitary gland. The placenta progressively concentrated Hg as gestation advanced to term, and milk concentration of amalgam Hg postpartum provides a potential source of Hg exposure to the newborn. It is concluded that accumulation of amalgam Hg progresses in maternal and fetal tissues to a steady state with advancing gestation and is maintained. Dental amalgam usage as a tooth restorative material in pregnant women and children should be reconsidered.

  15. Critical experiments on low-enriched uranium oxide systems with H/U = 2.03

    International Nuclear Information System (INIS)

    Seven critical experiments were performed on a horizontal split table machine using 4.48% enriched 235U uranium oxide (U3O8). The oxide was compacted to a density of 4.68 g/cm3 and placed in 152-mm cubical aluminum cans. Water was added to achieve an H/U atomic ratio of 2.03. Various arrays of oxide cans were distributed on each half of the split table and the separation between halves reduced until criticality occurred. The critical table separation varied from 4.3 mm to 29.3 mm. These experiments were performed in both plastic and concrete reflectors. The first five experiments required the addition of a high-enriched (approx. 93% 235U) metal driver to achieve criticality. Critical uranium driver masses ranged from 2.765 kg to 13.730 kg for 5 x 5 x 5 arrays of uranium oxide cans. In all five cases, the center can of the array was deleted to accommodate the driver. The uranium oxide mass was 1859.6 kg. Two additional experiments in the plastic reflector contained either 9.3-mm- or 24.3-mm-thick plastic moderator material between the oxide cans. These latter experiments did not require a driver to achieve criticality; and the uranium oxide mass was 723.9 kg for the configuration having the thinner interstitial moderator and 452.4 kg for the other

  16. Maternal-fetal distribution of mercury (203Hg) released from dental amalgam fillings

    International Nuclear Information System (INIS)

    In humans, the continuous release of Hg vapor from dental amalgam tooth restorations is markedly increased for prolonged periods after chewing. The present study establishes a time-course distribution for amalgam Hg in body tissues of adult and fetal sheep. Under general anesthesia, five pregnant ewes had twelve occlusal amalgam fillings containing radioactive 203Hg placed in teeth at 112 days gestation. Blood, amniotic fluid, feces, and urine specimens were collected at 1- to 3-day intervals for 16 days. From days 16-140 after amalgam placement (16-41 days for fetal lambs), tissue specimens were analyzed for radioactivity, and total Hg concentrations were calculated. Results demonstrate that Hg from dental amalgam will appear in maternal and fetal blood and amniotic fluid within 2 days after placement of amalgam tooth restorations. Excretion of some of this Hg will also commence within 2 days. All tissues examined displayed Hg accumulation. Highest concentrations of Hg from amalgam in the adult occurred in kidney and liver, whereas in the fetus the highest amalgam Hg concentrations appeared in liver and pituitary gland. The placenta progressively concentrated Hg as gestation advanced to term, and milk concentration of amalgam Hg postpartum provides a potential source of Hg exposure to the newborn. It is concluded that accumulation of amalgam Hg progresses in maternal and fetal tissues to a steady state with advancing gestation and is maintained. Dental amalgam usage as a tooth restorative material in pregnant women and children should be reconsidered

  17. Polymorphism of Gly482Ser PPARGC 1A and Ala203Pro PPARGC 1B in the pathogenesis of Graves’ orbitopathy

    Directory of Open Access Journals (Sweden)

    D M Serkin

    2015-06-01

    Full Text Available Aim. To examine the association of polymorphisms Gly482Ser PPARGC 1A and Ala203Pro PPARGC 1B with the development of thyroid eye disease (TEO. Materials and methods. A total of 88 people: 52 patients with TEO, 36 - healthy individuals. Identified polymorphisms Gly482Ser PPARGC 1A and Ala203Pro PPARGC 1B by PCR. Results. When TEO detected differences in the frequency of allele and genotype SNPs investigated compared with the control. The prevalence of genotypes and alleles in patients with TEO (Gly/Gly - 38.5%, Gly/Ser - 34.6%, Ser/Ser - 26.9%, Gly-allele - 55.8%, Ser-allele - 44.2% gene PPARGC 1A; Ala/Ala - 19.2%, Ala/Pro - 55.8%, Pro/Pro - 25%, Ala-allele - 47.1%, Pro-allele - 52.9% gene PPARGC 1B. The prevalence of genotypes and alleles in the control group (Gly/Gly - 38.9%, Gly/Ser - 44.4%, Ser/Ser - 16.7%, Gly-allele - 61.1%, Ser-allele - 38.9% of the gene PPARGC 1A; Ala/Ala - 25%, Ala/Pro - 58.3%, Pro/Pro - 16.7%, Ala-allele - 54.2%, Pro-allele - 45.8% of the gene PPARGC 1B. Conclusion. At TEO more common genotypes Ser482Ser PPARGC 1A, Pro203Pro PPARGC 1B and Ser allele polymorphism Gly482Ser PPARGC 1A, Pro polymorphism Ala203Pro PPARGC 1B, as well as less common genotypes Gly482Ser PPARGC 1A, Ala203Ala PPARGC 1B and Gly allele polymorphism Gly482Ser PPARGC 1A, Ala polymorphism Ala203Pro PPARGC 1B. Polymorphisms and allele Gly482Ser PPARGC 1A gene and gene Ala203Pro PPARGC 1B do not modify the risk of TEO.

  18. A DISCUSSION ON THE IMPROVEMENT OF THE APPLICATION ACCURACY OF THE TSP203 SYSTEM%如何提高TSP203系统在应用中的准确性

    Institute of Scientific and Technical Information of China (English)

    舒森

    2011-01-01

    The transport engineering has massive tunnel construction, and the tunnel construction is likely to be affected by adverse geological structures. In order to reduce the influence of geological disaster on tunnel construction, researchers use the TSP2O3 geological forecast system to carry out the survey in front of the tunnel face and provide in advance geological prediction that could give instructions for the following construction; nevertheless, due to the existence of much misinformation in the practical application, these means often fail to report the situation or the accurate of the report is too low. These problems often result from the insufficient data acquisition and data processing. Through standard data acquisition and reasonable data processing, the adverse effect might be reduced, and the application accuracy of the TSP203 system in the geological forecast could be improved.%为了减少地质灾害对隧道施工的影响,采用 TSP203超前地质预报系统对隧道掌子面前方进行探测,提供超前地质预报,为后续施工提供指导.但是,在实际应用中出现了很多误报、漏报或者准确性太低的情况,这些问题往往是由于数据采集和数据处理中的不足带来的.通过规范的数据采集和合理的数据处理,可以减少这些不足的不良影响,从而提高TSP203系统在超前地质预报应用中的准确性.

  19. Synthesis and characterization in monkey of [{sup 11}C]SP203 as a radioligand for imaging brain metabotropic glutamate 5 receptors

    Energy Technology Data Exchange (ETDEWEB)

    Simeon, Fabrice G.; Liow, Jeih-San; Zhang, Yi; Hong, Jinsoo; Gladding, Robert L.; Zoghbi, Sami S.; Innis, Robert B.; Pike, Victor W. [National Institutes of Health, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD (United States)

    2012-12-15

    [{sup 18}F]SP203 (3-fluoro-5-(2-(2-([{sup 18}F]fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile) is an effective high-affinity and selective radioligand for imaging metabotropic 5 receptors (mGluR5) in human brain with PET. To provide a radioligand that may be used for more than one scanning session in the same subject in a single day, we set out to label SP203 with shorter-lived {sup 11}C (t{sub 1/2} = 20.4 min) and to characterize its behavior as a radioligand with PET in the monkey. Iodo and bromo precursors were obtained by cross-coupling 2-fluoromethyl-4-((trimethylsilyl)ethynyl)-1,3-thiazole with 3,5-diiodofluorobenzene and 3,5-dibromofluorobenzene, respectively. Treatment of either precursor with [{sup 11}C]cyanide ion rapidly gave [{sup 11}C]SP203, which was purified with high-performance liquid chromatography. PET was used to measure the uptake of radioactivity in brain regions after injecting [{sup 11}C]SP203 intravenously into rhesus monkeys at baseline and under conditions in which mGluR5 were blocked with 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP). The emergence of radiometabolites in monkey blood in vitro and in vivo was assessed with radio-HPLC. The stability of [{sup 11}C]SP203 in human blood in vitro was also measured. The iodo precursor gave [{sup 11}C]SP203 in higher radiochemical yield (>98 %) than the bromo precursor (20-52 %). After intravenous administration of [{sup 11}C]SP203 into three rhesus monkeys, radioactivity peaked early in brain (average 12.5 min) with a regional distribution in rank order of expected mGluR5 density. Peak uptake was followed by a steady decline. No radioactivity accumulated in the skull. In monkeys pretreated with MTEP before [{sup 11}C]SP203 administration, radioactivity uptake in brain was again high but then declined more rapidly than in the baseline scan to a common low level. [{sup 11}C]SP203 was unstable in monkey blood in vitro and in vivo, and gave predominantly less lipophilic radiometabolites

  20. Epidermal anti-Inflammatory properties of 5,11,14 20:3: Effects on mouse ear edema, PGE2 levels in cultured keratinocytes, and PPAR activation

    Directory of Open Access Journals (Sweden)

    Baur Markus

    2002-12-01

    Full Text Available Abstract Background 5,11,14 20:3 is similar to 20:4n-6 but lacks the internal Δ8 double bond essential for prostaglandin and eicosanoid synthesis. When previously fed to laboratory animals as a gymnosperm seed oil component it has shown anti-inflammatory properties. Results Herein, topically applied Podocarpus nagi methyl esters (containing 26% 5,11,14 20:3 were incorporated into mouse ear phospholipids, reduced 20:4n-6, and reduced 20:4n-6- and TPA-induced mouse ear edema. Purified 5,11,14 20:3 was taken up by cultured human skin keratinocytes, reduced 20:4n-6, and reduced PGE2 levels dramatically. Purified 5,11,14 20:3 did not affect PPARα, PPARγ, or PPARδ transactivation. Conclusions Topical application of 5,11,14 20:3 to skin surfaces can thus reduce inflammatory processes, most likely by displacing 20:4n-6 from phospholipid pools and reducing downstream inflammatory products derived from 20:4n-6 such as PGE2 and leukotrienes. It could have potential use in treating clinical skin disorders resulting from overproduction of 20:4n-6-derived eicosanoid products.

  1. Investigation of the /sup 203/ /sup 205/Tl level schemes after (n,n'gamma) reactions at 2. 75 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Wohlfarth, H.; Kretz, R.; Backe, H.; Hegewisch, S.; Vonach, H.

    1980-06-01

    Some 259 gamma-lines have been observed with Ge(Li) detectors from (/sup 203/ /sup 205/)Tl(n,n'gamma) reactions with 2.75 MeV neutrons using (/sup nat/)Tl and enriched (/sup 203/)Tl samples. The different gamma lines could be attributed unambiguously to the (/sup 203/)Tl and (/sup 205/)Tl isotopes. It was possible to assign only 60 and 54 transitions to the known level schemes of (/sup 203/)Tl and (/sup 205/)Tl, respectively. From these facts it can be concluded that the low spin members in (/sup 203/ /sup 205/) Tl between 1.5 and 2.7 MeV are only partially known. The decay of a 5/2/sup -/ level at 2623.1 keV in (205)Tl was identified and the corresponding transition energies have been measured. With these results isomer shifts of general gamma lines corresponding to the decay of the same 5/2/sup -/ level in muonic (/sup 205/)Tl were determined.

  2. Investigation of 203,205Hg with the (d,pγ) reaction - identification of the i13/2 neutron hole state in 205Hg

    International Nuclear Information System (INIS)

    Low lying levels in 203Hg and 205Hg were studied with the (d, p) deuteron break-up reaction at Ed=14 and 18 MeV. Gamma-rays and conversion-electrons were measured in coincidence with protons. In addition delayed spectra were recorded with μs and ms beam pulsing. The i13/2 neutron hole state was identified in 205Hg and confirmed in 203Hg. The known level structure of 205Hg below 2 MeV is confirmed and extended. For 203Hg we observe the γ-decay of several levels below 1.5 MeV, which were previously known from transfer reactions. (orig.)

  3. The designing of afforestation model on the road segment from Yiershi to Aershan of the S203 line%省道203线伊尔施至阿尔山段营造林模式设计

    Institute of Scientific and Technical Information of China (English)

    陶桂云; 石慧; 赵田义

    2012-01-01

    针对内蒙古自治区省道203线伊尔施至阿尔山段道路自然环境、交通旅游环境及立地条件进行了调查研究和分析,形成该路段绿色走廊营造林模式设计指导思想与原则,总结出代表大兴安岭寒温带地区的道路绿化美化营造林模式,为绿色通道工程等生态环境建设提供可靠技术支撑。%The natural environment, transportation and tour environment and ground terms of the road segment from Yiershi to Aershan of the S203 Line in Inner Mongolia have been researched and analyzed. It was formed that the guide thought and principle of afforestation model in the green hallway ,and the afforostation and beautification models that can represent the cold temperate zone in the Great Xingean Mountains were summarized, provided the dependable theo- ries and technique support for ecological environment construction such as the green passage engineering etc.

  4. Upregulation of miR-203 and miR-210 affect growth and differentiation of keratinocytes after exposure to sulfur mustard in normoxia and hypoxia.

    Science.gov (United States)

    Deppe, Janina; Steinritz, Dirk; Santovito, Donato; Egea, Virginia; Schmidt, Annette; Weber, Christian; Ries, Christian

    2016-02-26

    Exposure of the skin to sulfur mustard (SM) results in long-term complications such as impaired tissue regeneration. Previous own studies in normal human epidermal keratinocytes (NHEK) treated with SM demonstrated reduced proliferation, premature differentiation and a restricted functionality of hypoxia-mediated signaling in the cells. Here, we investigated the involvement of microRNAs, miR-203 and miR-210, in these mechanisms. SM significantly upregulated the expression of miR-203 in NHEK when cultivated under normoxic and hypoxic conditions. SM had no effect on miR-210 under normoxia. However, miR-210 levels were greatly increased in NHEK when grown in hypoxia and further elevated upon exposure of the cells to SM. In normoxia and hypoxia, inhibition of miR-203 by transfection of NHEK with complementary oligonucleotides, anti-miR-203, attenuated the SM-induced impairment of metabolic activity and proliferation, and counteracted SM-promoted keratin-1 expression in these cells. Consistent ameliorating effects on dysregulated metabolic activity, proliferation and keratin-1 expression in SM-treated NHEK were obtained upon inhibition of miR-210 in these cells grown in hypoxia. Our findings provide evidence that miR-203 and miR-210 are key regulators in normal and SM-impaired keratinocyte functionality, and suggest potential usefulness of inhibitors against miR-203 and miR-210 for target-directed therapeutical intervention to improve re-epithelialization of SM-injured skin. PMID:26383628

  5. Hanford Tanks 241-C-202 and 241-C-203 Residual Waste Contaminant Release Models and Supporting Data

    Energy Technology Data Exchange (ETDEWEB)

    Deutsch, William J.; Krupka, Kenneth M.; Lindberg, Michael J.; Cantrell, Kirk J.; Brown, Christopher F.; Mattigod, Shas V.; Schaef, Herbert T.; Arey, Bruce W.

    2007-09-13

    As directed by Congress, the U. S. Department of Energy (DOE) established the Office of River Protection in 1998 to manage DOE's largest, most complex environmental cleanup project – retrieval of radioactive waste from Hanford tanks for treatment and eventual disposal. Sixty percent by volume of the nation's high-level radioactive waste is stored at Hanford in aging deteriorating tanks. If not cleaned up, this waste is a threat to the Columbia River and the Pacific Northwest. CH2M Hill Hanford Group, Inc., is the Office of River Protection's prime contractor responsible for the storage, retrieval, and disposal of Hanford's tank waste. As part of this effort, CH2M HILL Hanford Group, Inc. contracted with Pacific Northwest National Laboratory (PNNL) to develop release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for DOE.

  6. Hanford Tanks 241-C-202 and 241-C-203 Residual Waste Contaminant Release Models and Supporting Data

    International Nuclear Information System (INIS)

    As directed by Congress, the U. S. Department of Energy (DOE) established the Office of River Protection in 1998 to manage DOE's largest, most complex environmental cleanup project retrieval of radioactive waste from Hanford tanks for treatment and eventual disposal. Sixty percent by volume of the nation's high-level radioactive waste is stored at Hanford in aging deteriorating tanks. If not cleaned up, this waste is a threat to the Columbia River and the Pacific Northwest. CH2M Hill Hanford Group, Inc., is the Office of River Protection's prime contractor responsible for the storage, retrieval, and disposal of Hanford's tank waste. As part of this effort, CH2M HILL Hanford Group, Inc. contracted with Pacific Northwest National Laboratory PNNL to develop release models for key contaminants that are present in residual sludge remaining after closure of Hanford Tanks 241-C-203 (C-203) and 241-C-204 (C-204). The release models were developed from data generated by laboratory characterization and testing of samples from these two tanks. These release models are being developed to support the tank closure risk assessments performed by CH2M HILL Hanford Group, Inc., for DOE.

  7. 45 CFR 2540.203 - When must I conduct a State criminal registry check and a National Sex Offender Public Web site...

    Science.gov (United States)

    2010-10-01

    ... check and a National Sex Offender Public Web site check on an individual in a covered position? 2540.203... National Sex Offender Public Web site check on an individual in a covered position? (a) The State criminal... enrolls in, or is hired by, your program on or after October 1, 2009. (b) The National Sex Offender...

  8. 41 CFR 302-3.203 - If I am transferring in the interest of the Government and my employed immediate family member(s...

    Science.gov (United States)

    2010-07-01

    ... the interest of the Government and my employed immediate family member(s) transfer is not in the... ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types of Transfers Relocation of Two Or More Employed Immediate Family Members § 302-3.203 If I am transferring in the interest of the Government and my...

  9. Factors Affecting Examination Attrition: Does Academic Support Help? A Survey of ACN203S (Cost Accounting and Control) Students at Unisa

    Science.gov (United States)

    Tladi, Lerato Sonia

    2013-01-01

    This study sought to determine the attributing and contributing factors to examination absence as well as whether the academic and social support available to students had a role to play in discouraging or reducing absence from examinations using results from a quantitative survey of ACN203S (Cost Accounting and Control) students who were admitted…

  10. Electro-acupuncture Treatment on 203 Cases for T2MD with Obesity%电针治疗T2DM伴肥胖203例研究

    Institute of Scientific and Technical Information of China (English)

    张娜; 刘志诚; 徐斌

    2014-01-01

    观察电针治疗2型糖尿(T2DM)病肥胖患者的疗效。方法:电针治疗203例T2DM伴肥胖患者。观察治疗3个月前后患者空腹血糖(FBS)、空腹胰岛素(FINS)、胰岛素敏感指数(ISI)、胰岛素抵抗指数(Homa-IR)、胰岛素分泌指数(Homa-茁)、肥胖度(A)、体质量(Kg)、体质指数(BMI)和体脂百分率(F%)的变化,观察肥胖和证型对电针降糖疗效的影响。结果:与治疗前相比,203例患者经治疗后,FINS、Homa-IR、FBS都有显著回降(P<0.01),ISI、Homa-茁显著回升(P<0.01),治疗前后比较胰岛茁细胞功能改善均有显著统计学意义;A、体质量、BMI、F%均显著下降(P<0.01)。肥胖能影响电针加耳针降糖疗效,证型无影响。结论:电针能显著纠正T2DM伴肥胖患者的血糖,保护胰岛茁细胞功能,并且能降低患者体质量。%This study was aimed to observe the effect of electro-acupuncture (EA) treatment on Zhong-Xiao (ZX, T2MD) with obesity. A total of 203 patients with ZX accompanied with obesity accepted EA treatment. Before and after 3-month treatment, observations were made on patients' fasting blood glucose (FBS), fasting insulin (FINS), in-sulin sensitivity index (ISI), insulin resistance index (Homa-IR), insulin secretion index (Homa-β), degree of obesity (A), body mass (Kg), body mass index (BMI) and body fat percentage (F%) changes. The results showed that com-pared with pretreatment, the posttreatment FINS, Homa-IR, FBS had a significant decrease among 203 patients (P<0.01); the ISI and Homa-β had a significant increase (P < 0.01). There was a significant statistical difference on islet β-cell function before and after treatment. The A, body mass, BMI, and F% were significantly decreased (P<0.01). It was concluded that EA can significantly correct ZX with obesity patients' glucose consumption, protect the islet β-cell function, and reduce the body mass of patients.

  11. 203例房颤患者中医辨证相关因素分析%Analysis on Relative Factors of Syndrome Differentiation in 203 Patients with Auricular Fibrillation

    Institute of Scientific and Technical Information of China (English)

    汪云翔

    2012-01-01

    目的:探求心房颤动中医分型与年龄、性别及相关疾病的关系.方法:选择203例房颤患者,按中医辨证分为瘀阻心脉、痰浊闭阻、水饮凌心、心血不足、阴虚火旺、心阳不振6型,比较不同性别、年龄以及有冠心病病史、风湿性心脏病病史、高血压病病史患者各中医证型的构成情况.结果:房颤病人以老年人居多,证型以瘀阻心脉、痰浊闭阻居多.有冠心病病史的房颤患者多为瘀阻心脉、痰浊闭阻型;有高血压性心脏病的患者辨证多为瘀阻心脉、阴虚火旺;风心病引起的房颤辨证多为水饮凌心、心血不足.结论:房颤患者的中医证型与其年龄及相关病史有关,临床辨证需考虑相关因素.%Objective: To find out the relationships between TCM pattern and aging, gender and associated diseases. Method: All 203 patients were divided into six groups according to TCM syndrome differentiation, which included: blood stasis obstructing the heart, phlegm turbidity obstruction, water intimidating the heart, heart blood deficiency, Yin deficiency and fire hyperactivity, devitalization of heart Yang. The syndromes of patients with the history of coronary heart disease, rheumatic heart disease and hypertension as well as their gender and ages were analyzed. Result: Most of the patients with auricular fibrillation are the elderly and their syndromes mostly are blood stasis obstructing the heart and phlegm turbidity obstruction; the patients with the history of coronary heart disease are also of blood stasis obstructing the heart and phlegm turbidity obstruction; the patients with the history of hypertensive heart disease are differentiated as blood stasis obstructing the heart and Yin deficiency and fire hyperactivity; auricular fibrillation induced by rheumatic heart disease is mostly differentiated as water intimidating the heart and heart blood deficiency. Conclusion: TCM syndrome of auricular fibrillation is associated to

  12. IER 203 CED-2 Report: LLNL Final Design for BERP Ball With a Composite Reflector of Thin Polyethylene Backed by Nickel

    Energy Technology Data Exchange (ETDEWEB)

    Percher, C. M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Heinrichs, D. P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kim, S. K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-07-18

    This report documents the results of final design (CED-2) for IER 203, BERP Ball Composite Reflection, and focuses on critical configurations with a 4.5 kg α-phase plutonium sphere reflected by a combination of thin high density polyethylene (HDPE) backed by a thick nickel reflector. The Lawrence Livermore National Laboratory’s (LLNL’s) Nuclear Criticality Safety Division, in support of fissile material operations, calculated surprisingly reactive configurations when a fissile core was surrounded by a thin, moderating reflector backed by a thick metal reflector. These composite reflector configurations were much more reactive than either of the single reflector materials separately. The calculated findings have resulted in a stricter-than-anticipated criticality control set, impacting programmatic work. IER 203 was requested in response to these seemingly anomalous calculations to see if the composite reflection effect could be shown experimentally.

  13. Influence of nutrient factors on the growth of Lactoccus latis subsp. Lactis DL-203 and its biosynthesis of Nisin%营养因素对乳酸乳球菌DL-203生长及其Nisin生物合成的影响

    Institute of Scientific and Technical Information of China (English)

    焦中高; 陈海昌; 刘茵

    2003-01-01

    对Nisin高产茵株乳酸乳球菌DL-203的营养要求及其对Nisin生物合成的影响进行了研究.结果表明,乳链茵肽的生物合成与DL-203的生长呈极显著正相关,乳酸乳球菌DL-203生长和合成Nisin的最佳碳源和氮源分别为蔗糖和大豆蛋白胨,其适宜浓度均为15~20g/L.磷酸盐对乳酸乳球菌DL-203生长及其Nisin生物合成具有极大的促进作用,其中以Na2HPO4效果最好,其浓度在224mmol/L以下时时茵体生长和Nisin生物合成具有较大的促进作用.

  14. Application of dual-axis accelerometer ADXL203 in perceptual foot system of humanoid robot%ADXL203型双轴加速计在机器人足部感知系统中的应用

    Institute of Scientific and Technical Information of China (English)

    申海义; 吴宝元; 任阳; 申飞; 吴仲城

    2012-01-01

    In complex environments, ground reaction force can not meet the demand of walking stably for humanoid robot, then angle information of foot is more important in this application. The feet dip angle can reflect the sloping ground state, it is an important basis of the humanoid robot stability control.The high-speed real-time collection and processing of angle information is realized by using ADXL2O3 dual axle acceleration sensor and DSP (TMS3202811), and through the experiment proof that the tilt sensors in the robot foot perception system is feasible.%仿人机器人要实现在复杂环境下稳定行走,仅仅依靠地面反力信息远不能满足应用要求,此时足部的倾角信息显得更为重要.脚面倾角可以反映地面倾斜状态,是仿人机器人稳定控制的一个重要依据.利用ADXL203双轴加速度传感器与DSP (TMS3202811)实现对倾角信息的实时高速采集与处理,并通过实验证明了倾角传感器在机器人足部感知系统中是可行的.

  15. IER 203 CED-2 Report: LLNL Final Design for BERP Ball With a Composite Reflector of Thin Polyethylene Backed by Nickel

    Energy Technology Data Exchange (ETDEWEB)

    Percher, C. M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Heinrichs, D. P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kim, S. K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-07-18

    This report documents the results of final design (CED-2) for IER 203, BERP Ball Composite Reflection, and focuses on critical configurations with a 4.5 kg α-phase plutonium sphere reflected by a combination of thin high-density polyethylene (HDPE) backed by a thick nickel reflector. The Lawrence Livermore National Laboratory’s (LLNL’s) Nuclear Criticality Safety Division, in support of fissile material operations, calculated surprisingly reactive configurations when a fissile core was surrounded by a thin, moderating reflector backed by a thick metal reflector. These composite reflector configurations were much more reactive than either of the single reflector materials separately. The calculated findings have resulted in a stricter-than-anticipated criticality control set, impacting programmatic work. IER 203 was requested in response to these seemingly anomalous calculations to see if the composite reflection effect could be shown experimentally. This report focuses on the Beryllium Reflected Plutonium (BERP) ball as a fissile material core reflected by polyethylene and nickel. A total of four critical configurations were designed as part of CED-2. Fabrication costs are estimated to be $98,500, largely due to the cost of the large nickel reflectors. The IER 203 experiments could reasonably be expected to begin in early FY2017,

  16. Experiences with explicit finite-difference schemes for complex fluid dynamics problems on STAR-100 and CYBER-203 computers

    Science.gov (United States)

    Kumar, A.; Rudy, D. H.; Drummond, J. P.; Harris, J. E.

    1982-08-01

    Several two- and three-dimensional external and internal flow problems solved on the STAR-100 and CYBER-203 vector processing computers are described. The flow field was described by the full Navier-Stokes equations which were then solved by explicit finite-difference algorithms. Problem results and computer system requirements are presented. Program organization and data base structure for three-dimensional computer codes which will eliminate or improve on page faulting, are discussed. Storage requirements for three-dimensional codes are reduced by calculating transformation metric data in each step. As a result, in-core grid points were increased in number by 50% to 150,000, with a 10% execution time increase. An assessment of current and future machine requirements shows that even on the CYBER-205 computer only a few problems can be solved realistically. Estimates reveal that the present situation is more storage limited than compute rate limited, but advancements in both storage and speed are essential to realistically calculate three-dimensional flow.

  17. Patterns and processes in crop domestication: an historical review and quantitative analysis of 203 global food crops.

    Science.gov (United States)

    Meyer, Rachel S; DuVal, Ashley E; Jensen, Helen R

    2012-10-01

    Domesticated food crops are derived from a phylogenetically diverse assemblage of wild ancestors through artificial selection for different traits. Our understanding of domestication, however, is based upon a subset of well-studied 'model' crops, many of them from the Poaceae family. Here, we investigate domestication traits and theories using a broader range of crops. We reviewed domestication information (e.g. center of domestication, plant traits, wild ancestors, domestication dates, domestication traits, early and current uses) for 203 major and minor food crops. Compiled data were used to test classic and contemporary theories in crop domestication. Many typical features of domestication associated with model crops, including changes in ploidy level, loss of shattering, multiple origins, and domestication outside the native range, are less common within this broader dataset. In addition, there are strong spatial and temporal trends in our dataset. The overall time required to domesticate a species has decreased since the earliest domestication events. The frequencies of some domestication syndrome traits (e.g. nonshattering) have decreased over time, while others (e.g. changes to secondary metabolites) have increased. We discuss the influences of the ecological, evolutionary, cultural and technological factors that make domestication a dynamic and ongoing process.

  18. Acute avulsion fractures of the pelvis in adolescent competitive athletes: prevalence, location and sports distribution of 203 cases collected

    International Nuclear Information System (INIS)

    Objective. To describe the prevalence, location and sports distribution of pelvic avulsion fractures in adolescent competitive athletes. Design and patients. One thousand two hundred and thirty-eight radiographs of the pelvis taken for focal traumatic symptoms in athletes with an age range of 11-35 years over a period of 22 years were reviewed. Results. One hundred and ninety-eight adolescent athletes were affected by 203 avulsion fractures of the pelvic apophyses (five cases presented multiple locations). The localisation was the ischial tuberosity (IT) in 109 cases, anterior inferior iliac spine (AIIS) in 45 cases, anterior superior iliac spine (ASIS) in 39 cases, superior corner of pubic symphysis (SCPS) in 7 cases and iliac crest (IC) in 3 cases. Soccer (74 cases) and gymnastics (55 cases) were the sports with the highest number of avulsion fractures documented. Conclusions. Apophyseal avulsion fractures of the pelvis in adolescent competitive athletes are most common in soccer and gymnastics. The lesions are usually the consequence of sudden and forceful muscle-tendon contractions during sport activities. Plain radiographs, are determinant for the diagnosis. (orig.)

  19. Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial–mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Dongjing [Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha 410008 (China); Wu, Jilin, E-mail: 6296082@qq.com [Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha 410008 (China); Liu, Meizhou [Department of Medical Service, Shenzhen Second People' s Hospital, Shenzhen, Guangdong 518035 (China); Yin, Hui [Staff' s Hospital, Central South University, Changsha, Hunan 410078 (China); He, Jiantai [Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha 410008 (China); Zhang, Bo, E-mail: zhangbo8095@126.com [Department of Ultrasonography, Xiangya Hospital, Central South University, Changsha, Hunan 410008 (China)

    2015-09-04

    Hepatitis C virus (HCV) Core protein has been demonstrated to induce epithelial–mesenchymal transition (EMT) and is associated with cancer progression of hepatocellular carcinoma (HCC). However, how the Core protein regulates EMT is still unclear. In this study, HCV Core protein was overexpressed by an adenovirus. The protein levels of EMT markers were measured by Western blot. The xenograft animal model was established by inoculation of HepG2 cells. Results showed that ectopic expression of HCV core protein induced EMT in L02 hepatocytes and HepG2 tumor cells by upregulating vimentin, Sanl1, and Snal2 expression and downregulating E-cadherin expression. Moreover, Core protein downregulated miR-30c and miR-203a levels in L02 and HepG2 cells, but artificial expression of miR-30c and miR-203a reversed Core protein-induced EMT. Further analysis showed that ectopic expression of HCV core protein stimulated cell proliferation, inhibited apoptosis, and increased cell migration, whereas artificial expression of miR-30c and miR-203a significantly reversed the role of Core protein in these cell functions in L02 and HepG2 cells. In the HepG2 xenograft tumor models, artificial expression of miR-30c and miR-203a inhibited EMT and tumor growth. Moreover, L02 cells overexpressing Core protein can form tumors in nude mice. In HCC patients, HCV infection significantly shortened patients' survival time, and loss of miR-30c and miR-203 expression correlated with poor survival. In conclusion, HCV core protein downregulates miR-30c and miR-203a expression, which results in activation of EMT in normal hepatocytes and HCC tumor cells. The Core protein-activated-EMT is involved in the carcinogenesis and progression of HCC. Loss of miR-30c and miR-203a expression is a marker for the poor prognosis of HCC. - Highlights: • HCV core protein downregulates miR-30c and miR-203a expression. • Downregulation of miR-30c and miR-203a activates EMT. • Activated-EMT is involved in the

  20. Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial–mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells

    International Nuclear Information System (INIS)

    Hepatitis C virus (HCV) Core protein has been demonstrated to induce epithelial–mesenchymal transition (EMT) and is associated with cancer progression of hepatocellular carcinoma (HCC). However, how the Core protein regulates EMT is still unclear. In this study, HCV Core protein was overexpressed by an adenovirus. The protein levels of EMT markers were measured by Western blot. The xenograft animal model was established by inoculation of HepG2 cells. Results showed that ectopic expression of HCV core protein induced EMT in L02 hepatocytes and HepG2 tumor cells by upregulating vimentin, Sanl1, and Snal2 expression and downregulating E-cadherin expression. Moreover, Core protein downregulated miR-30c and miR-203a levels in L02 and HepG2 cells, but artificial expression of miR-30c and miR-203a reversed Core protein-induced EMT. Further analysis showed that ectopic expression of HCV core protein stimulated cell proliferation, inhibited apoptosis, and increased cell migration, whereas artificial expression of miR-30c and miR-203a significantly reversed the role of Core protein in these cell functions in L02 and HepG2 cells. In the HepG2 xenograft tumor models, artificial expression of miR-30c and miR-203a inhibited EMT and tumor growth. Moreover, L02 cells overexpressing Core protein can form tumors in nude mice. In HCC patients, HCV infection significantly shortened patients' survival time, and loss of miR-30c and miR-203 expression correlated with poor survival. In conclusion, HCV core protein downregulates miR-30c and miR-203a expression, which results in activation of EMT in normal hepatocytes and HCC tumor cells. The Core protein-activated-EMT is involved in the carcinogenesis and progression of HCC. Loss of miR-30c and miR-203a expression is a marker for the poor prognosis of HCC. - Highlights: • HCV core protein downregulates miR-30c and miR-203a expression. • Downregulation of miR-30c and miR-203a activates EMT. • Activated-EMT is involved in the

  1. Metal transfer to plants grown on a dredged sediment: use of radioactive isotope 203Hg and titanium

    International Nuclear Information System (INIS)

    Improperly disposed of dredged sediments contaminated with metals may induce long-term leaching and an increase of metal concentrations in ground waters and vegetal cover plants. The objective of the study was to quantify the sediment-to-plant transfer of Cu, Pb, Hg and Zn with a particular focus on the pathway of Hg and to determine whether the establishment of vegetal cover modifies the metal availability. A pot experiment with rape (Brassica napus), cabbage (Brassica oleraccea) and red fescue (Festuca rubra) was set up using a sediment first spiked with the radioisotope 203Hg. Zinc concentrations (197-543 mg kg-1 DM) in leaves were higher than Cu concentration (197-543 mg kg-1 DM), Pb concentration (2.3-2.6 mg kg-1 DM) and Hg concentration (0.9-1.7 mg kg-1 DM). Leaves-to-sediment ratios decreased as follows: Zn>Cu>Hg>Pb. According to Ti measurements, metal contamination by dry deposition was less than 1%. Mercury concentration in plant leaves was higher than European and French thresholds. Foliar absorption of volatile Hg was a major pathway for Hg contamination with a root absorption of Hg higher in rape than in cabbage and red fescue. Growth of each species increased Cu solubility. Zinc solubility was increased only in the presence of rape. The highest increase of Cu solubility was observed for red fescue whereas this species largely decreased Zn solubility. Dissolved organic carbon (DOC) measurements suggested that Cu solubilisation could result from organic matter or release of natural plant exudates. Dissolved inorganic carbon (DIC) measures suggested that the high Zn solubility in the presence of rape could originate from a generation of acidity in rape rhizosphere and a subsequent dissolution of calcium carbonates. Consequently, emission of volatile Hg from contaminated dredged sediments and also the potential increase of metal solubility by a vegetal cover of grass when used in phytostabilisation must be taken into account by decision makers

  2. NMR-ON measurement s of 187WFe, 187,183,186ReNi, 186ReFe and 203PbFe

    International Nuclear Information System (INIS)

    The magnetic hyperfine splitting frequencies of 187WFe, 182Re(jπ = 2+)Ni, 186ReNi, 186ReFe, 186ReFe and 203PbFe in a zero external magnetic field have been determined by the NMR-ON method at about 7 mK as 225.56(6), 130.9(1), 98.17(4), 136.6(4), 1007.0(3) and 58.43(3) MHz, respectively. With the known g-factors of g(186Re, 1-) = 1.739(3) and g(203Pb, 5/2-) = 0.27456(20), the following hyperfine fields were deduced: BHF(186ReNi) = -103.05(35) kG; BHF(186ReFe) = -759.7(13) kG; BHF(203PbFe) = +279.18(25) kG. Taking hyperfine anomalies into account, the g-factor of 183Re was deduced as vertical strokeg(183Re, 5/2+)vertical stroke = 1.267(6). With the assumption of Knight shift factor K = 0, the g-factors of 182Re and 187W and the hyperfine field of 187WFe were determined as vertical strokeg(182Re, 2+)vertical stroke = 1.63(5), vertical strokeg(187W, 3/2-)vertical stroke = 0.414(10) and BHF(187WFe) = -714(18) kG. The large hyperfine anomaly was deduced to be 183W Δ 187W = -0.124(22). (orig.)

  3. Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency.

    Science.gov (United States)

    Ichi, Ikuyo; Kono, Nozomu; Arita, Yuka; Haga, Shizuka; Arisawa, Kotoko; Yamano, Misato; Nagase, Mana; Fujiwara, Yoko; Arai, Hiroyuki

    2014-01-01

    In mammals, 5,8,11-eicosatrienoic acid (Mead acid, 20:3n-9) is synthesized from oleic acid during a state of essential fatty acid deficiency (EFAD). Mead acid is thought to be produced by the same enzymes that synthesize arachidonic acid and eicosapentaenoic acid, but the genes and the pathways involved in the conversion of oleic acid to Mead acid have not been fully elucidated. The levels of polyunsaturated fatty acids in cultured cells are generally very low compared to those in mammalian tissues. In this study, we found that cultured cells, such as NIH3T3 and Hepa1-6 cells, have significant levels of Mead acid, indicating that cells in culture are in an EFAD state under normal culture conditions. We then examined the effect of siRNA-mediated knockdown of fatty acid desaturases and elongases on the level of Mead acid, and found that knockdown of Elovl5, Fads1, or Fads2 decreased the level of Mead acid. This and the measured levels of possible intermediate products for the synthesis of Mead acid such as 18:2n-9, 20:1n-9 and 20:2n-9 in the knocked down cells indicate two pathways for the synthesis of Mead acid: pathway 1) 18:1n-9→(Fads2)→18:2n-9→(Elovl5)→20:2n-9→(Fads1)→20:3n-9 and pathway 2) 18:1n-9→(Elovl5)→20:1n-9→(Fads2)→20:2n-9→(Fads1)→20:3n-9. PMID:24184513

  4. 201-Tl production studies by 203-Tl(p,3n)201-Pb and 202-Hg(p,2n) nuclear reactions

    Energy Technology Data Exchange (ETDEWEB)

    Birattari, C.; Bonardi, M.; Salomone, A. (Milan Univ. (Italy). Ist. di Fisica)

    Thallium 201 has been produced in the Milan university AVF cyclotron by a /sup 203/Tl(p,3n)/sup 201/Pb and /sup 202/Hg(p,2n) nuclear reactions. /sup 201/Tl//sup 201/Pb were separated radiochemically by the preparation of thallium as thallous iodide after complexation of the lead with EDTA. /sup 202/Hg and /sup 201/Tl were separated by washing the target and holder, to which the radiothallium adheres with 3HCl and adding NaOH. Quality control is by radiochromatography.

  5. Metal transfer to plants grown on a dredged sediment: use of radioactive isotope {sup 203}Hg and titanium

    Energy Technology Data Exchange (ETDEWEB)

    Caille, Nathalie [ENSAIA-INRA/INPL, 2 avenue de la Foret de Haye, F-54505 Vandoeuvre-les-Nancy (France); CNRSSP, 930 boulevard Lahure, F-59505 Douai (France); Laboratoire des Interactions Microorganismes-Mineraux-Matiere organique dans les sols, CNRS, 17 rue Notre-Dame des Pauvres, F-54505 Vandoeuvre-les-Nancy (France); Vauleon, Clotilde [CNRSSP, 930 boulevard Lahure, F-59505 Douai (France); Leyval, Corinne [Laboratoire des Interactions Microorganismes-Mineraux-Matiere organique dans les sols, CNRS, 17 rue Notre-Dame des Pauvres, F-54505 Vandoeuvre-les-Nancy (France); Morel, Jean-Louis [ENSAIA-INRA/INPL, 2 avenue de la Foret de Haye, F-54505 Vandoeuvre-les-Nancy (France)]. E-mail: jean-louis.Morel@ensaia.inpl-nancy.fr

    2005-04-01

    Improperly disposed of dredged sediments contaminated with metals may induce long-term leaching and an increase of metal concentrations in ground waters and vegetal cover plants. The objective of the study was to quantify the sediment-to-plant transfer of Cu, Pb, Hg and Zn with a particular focus on the pathway of Hg and to determine whether the establishment of vegetal cover modifies the metal availability. A pot experiment with rape (Brassica napus), cabbage (Brassica oleraccea) and red fescue (Festuca rubra) was set up using a sediment first spiked with the radioisotope {sup 203}Hg. Zinc concentrations (197-543 mg kg{sup -1} DM) in leaves were higher than Cu concentration (197-543 mg kg{sup -1} DM), Pb concentration (2.3-2.6 mg kg{sup -1} DM) and Hg concentration (0.9-1.7 mg kg{sup -1} DM). Leaves-to-sediment ratios decreased as follows: Zn>Cu>Hg>Pb. According to Ti measurements, metal contamination by dry deposition was less than 1%. Mercury concentration in plant leaves was higher than European and French thresholds. Foliar absorption of volatile Hg was a major pathway for Hg contamination with a root absorption of Hg higher in rape than in cabbage and red fescue. Growth of each species increased Cu solubility. Zinc solubility was increased only in the presence of rape. The highest increase of Cu solubility was observed for red fescue whereas this species largely decreased Zn solubility. Dissolved organic carbon (DOC) measurements suggested that Cu solubilisation could result from organic matter or release of natural plant exudates. Dissolved inorganic carbon (DIC) measures suggested that the high Zn solubility in the presence of rape could originate from a generation of acidity in rape rhizosphere and a subsequent dissolution of calcium carbonates. Consequently, emission of volatile Hg from contaminated dredged sediments and also the potential increase of metal solubility by a vegetal cover of grass when used in phytostabilisation must be taken into account

  6. Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents

    International Nuclear Information System (INIS)

    We investigated the chemopreventive effects of naturally occurring compounds like butyric acid (BA), nicotinamide (NA) and calcium glucarate (CAG) individually or in combination in 7, 12-dimethylbenz [a] anthracene (DMBA) treated mouse skin at 4 and 16 weeks, the time before and after the tumor development. DMBA application did not show any skin tumors at 4 weeks but well defined tumors appeared at 16 weeks. BA, NA or CAG prevented the tumor development significantly but the protection was highly enhanced when all these compounds were given together. In order to see the molecular changes progressing with tumors, we showed the downregulation of tumor suppressor miR-203 at 16 weeks and upregulation of histone deacetylases (HDAC), DNA methyltransferase, promoter methylation of miR-203 at 4 or 16 weeks. Regulators of micro RNA biogenesis such as DICER1 and Ago2 were also deregulated by DMBA. Proto-oncogene c-myc and BMI1 were upregulated and tumor suppressor gene p16 was downregulated by DMBA as a function of time. Effects of BA, NA or CAG were more pronounced after 16 weeks as compared to 4 weeks in preventing the tumor development and altered gene expression. Concomitant administration of BA, NA and CAG tried to prevent these alterations more effectively than that of individual compound possibly by regulating miR-203 status through epigenetic or biogenetic modulations before and after the tumor development. Study provides a rationale for chemoprevention by combination of different compounds targeting miR-203. - Highlights: • DMBA modulates miR-203 and its regulator before and after the onset of tumors. • Suppression of miR-203 and p16 could be the result of gene promoter methylation. • BA, NA or CAG prevents the effects of DMBA. • Combination of BA, NA or CAG is more effective in preventing the DMBA modulations

  7. Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents

    Energy Technology Data Exchange (ETDEWEB)

    Tiwari, Prakash; Gupta, Krishna P., E-mail: krishnag522@yahoo.co.in

    2014-07-15

    We investigated the chemopreventive effects of naturally occurring compounds like butyric acid (BA), nicotinamide (NA) and calcium glucarate (CAG) individually or in combination in 7, 12-dimethylbenz [a] anthracene (DMBA) treated mouse skin at 4 and 16 weeks, the time before and after the tumor development. DMBA application did not show any skin tumors at 4 weeks but well defined tumors appeared at 16 weeks. BA, NA or CAG prevented the tumor development significantly but the protection was highly enhanced when all these compounds were given together. In order to see the molecular changes progressing with tumors, we showed the downregulation of tumor suppressor miR-203 at 16 weeks and upregulation of histone deacetylases (HDAC), DNA methyltransferase, promoter methylation of miR-203 at 4 or 16 weeks. Regulators of micro RNA biogenesis such as DICER1 and Ago2 were also deregulated by DMBA. Proto-oncogene c-myc and BMI1 were upregulated and tumor suppressor gene p16 was downregulated by DMBA as a function of time. Effects of BA, NA or CAG were more pronounced after 16 weeks as compared to 4 weeks in preventing the tumor development and altered gene expression. Concomitant administration of BA, NA and CAG tried to prevent these alterations more effectively than that of individual compound possibly by regulating miR-203 status through epigenetic or biogenetic modulations before and after the tumor development. Study provides a rationale for chemoprevention by combination of different compounds targeting miR-203. - Highlights: • DMBA modulates miR-203 and its regulator before and after the onset of tumors. • Suppression of miR-203 and p16 could be the result of gene promoter methylation. • BA, NA or CAG prevents the effects of DMBA. • Combination of BA, NA or CAG is more effective in preventing the DMBA modulations.

  8. Efficacy and complications of ultrasound-guided percutaneous renal biopsy using 18 G automatic biopsy gun in diffuse renal disease: Analysis of 203 cases

    Energy Technology Data Exchange (ETDEWEB)

    Gwon, Dong Il; Lee, Kang Hoon; Song, Kyung Sup; An, Suk Joo; Son, Sang Bum; Kim, Hyeon Suk [The Catholic University of Korea, St. Paul' s Hospital, Seoul (Korea, Republic of); Kim, Jee Young; Kim, Won Young; Park, Young Ha [The Catholic University of Korea, St. Vincent' s Hospital, Suwon (Korea, Republic of)

    2000-12-15

    To evaluate the efficacy and complications of ultrasound-guided percutaneous renal biopsy using 18G automatic biopsy gun in patients with diffuse renal disease. 203 ultrasound-guided renal biopsies using 18G automatic biopsy gun were performed in 197 patients for the diagnosis of diffuse renal disease. The success and complication rates were retrospectively evaluated by analysis of pathologic and clinical records and post-procedure ultrasonograms of the patients. Out of 203 renal biopsies, adequate tissues for pathologic diagnosis were obtained in 184 (90.6%) biopsies. The mean number of needle passes was 2.08, and the mean number of retrieved glomeruli was 7.71 {+-} 4.23. Minor complications occurred in seven biopsies (3.45%) including asymptomatic macroscopic hematuria in five (2.45%) and small subcapsular hematomas in two (1%). No patients required transfusion or surgery because of biopsy-related complication. Ultrasound-guided percutaneous renal biopsy using 18G automatic biopsy gun was an effective method for the pathologic diagnosis of diffuse renal disease and safe with low complication rate related to the procedure.

  9. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness.

    Science.gov (United States)

    Le, Lily Thao-Nhi; Cazares, Oscar; Mouw, Janna K; Chatterjee, Sharmila; Macias, Hector; Moran, Angel; Ramos, Jillian; Keely, Patricia J; Weaver, Valerie M; Hinck, Lindsay

    2016-03-14

    Breast tumor progression is accompanied by changes in the surrounding extracellular matrix (ECM) that increase stiffness of the microenvironment. Mammary epithelial cells engage regulatory pathways that permit dynamic responses to mechanical cues from the ECM. Here, we identify a SLIT2/ROBO1 signaling circuit as a key regulatory mechanism by which cells sense and respond to ECM stiffness to preserve tensional homeostasis. We observed that Robo1 ablation in the developing mammary gland compromised actin stress fiber assembly and inhibited cell contractility to perturb tissue morphogenesis, whereas SLIT2 treatment stimulated Rac and increased focal adhesion kinase activity to enhance cell tension by maintaining cell shape and matrix adhesion. Further investigation revealed that a stiff ECM increased Robo1 levels by down-regulating miR-203. Consistently, patients whose tumor expressed a low miR-203/high Robo1 expression pattern exhibited a better overall survival prognosis. These studies show that cells subjected to stiffened environments up-regulate Robo1 as a protective mechanism that maintains cell shape and facilitates ECM adherence.

  10. A comparison of the neuroprotective efficacy of individual oxime (HI-6) and combinations of oximes (HI-6+trimedoxime, HI-6+K203) in soman-poisoned rats.

    Science.gov (United States)

    Kassa, Jiri; Karasova, Jana Zdarova; Tesarova, Sandra

    2011-07-01

    The ability of two combinations of oximes (HI-6+trimedoxime, HI-6+K203) to reduce soman-induced acute neurotoxic signs and symptoms was compared with the neuroprotective efficacy of the oxime HI-6 alone, using a functional observational battery. Soman-induced neurotoxicity and the neuroprotective effects of HI-6 alone and HI-6 combined with trimedoxime or K203 in rats poisoned with soman at a sublethal dose (90 μg/kg intramuscularly, i.m.; 80% of LD₅₀ value) were monitored by the functional observational battery at 24 hours following soman administration. The results indicate that both tested oxime mixtures combined with atropine were able to allow soman-poisoned rats to survive 24 hours following soman challenge, while 4 nontreated soman-poisoned rats and 1 soman-poisoned rat treated with oxime HI-6 alone combined with atropine died within 24 hours following soman poisoning. While the oxime HI-6 alone combined with atropine treatment was able to eliminate a few soman-induced neurotoxic signs and symptoms, both oxime mixtures showed higher neuroprotective efficacy in soman-poisoned rats. Especially, the combination of HI-6 with trimedoxime was able to eliminate most soman-induced neurotoxic signs and symptoms and markedly reduce acute neurotoxicity of soman in rats. Thus, both tested mixtures of oximes combined with atropine were able to increase the neuroprotective effectiveness of antidotal treatment of acute soman poisonings, compared to the individual oxime.

  11. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness

    Science.gov (United States)

    Le, Lily Thao-Nhi; Cazares, Oscar; Mouw, Janna K.; Chatterjee, Sharmila; Macias, Hector; Moran, Angel; Ramos, Jillian; Keely, Patricia J.; Weaver, Valerie M.

    2016-01-01

    Breast tumor progression is accompanied by changes in the surrounding extracellular matrix (ECM) that increase stiffness of the microenvironment. Mammary epithelial cells engage regulatory pathways that permit dynamic responses to mechanical cues from the ECM. Here, we identify a SLIT2/ROBO1 signaling circuit as a key regulatory mechanism by which cells sense and respond to ECM stiffness to preserve tensional homeostasis. We observed that Robo1 ablation in the developing mammary gland compromised actin stress fiber assembly and inhibited cell contractility to perturb tissue morphogenesis, whereas SLIT2 treatment stimulated Rac and increased focal adhesion kinase activity to enhance cell tension by maintaining cell shape and matrix adhesion. Further investigation revealed that a stiff ECM increased Robo1 levels by down-regulating miR-203. Consistently, patients whose tumor expressed a low miR-203/high Robo1 expression pattern exhibited a better overall survival prognosis. These studies show that cells subjected to stiffened environments up-regulate Robo1 as a protective mechanism that maintains cell shape and facilitates ECM adherence. PMID:26975850

  12. The Roles of miR-26, miR-29, and miR-203 in the Silencing of the Epigenetic Machinery during Melanocyte Transformation.

    Science.gov (United States)

    Gasque Schoof, Cláudia Regina; Izzotti, Alberto; Jasiulionis, Miriam Galvonas; Vasques, Luciana Dos Reis

    2015-01-01

    The epigenetic marks located throughout the genome exhibit great variation between normal and transformed cancer cells. While normal cells contain hypomethylated CpG islands near gene promoters and hypermethylated repetitive DNA, the opposite pattern is observed in cancer cells. Recently, it has been reported that alteration in the microenvironment of melanocyte cells, such as substrate adhesion blockade, results in the selection of anoikis-resistant cells, which have tumorigenic characteristics. Melanoma cells obtained through this model show an altered epigenetic pattern, which represents one of the first events during the melanocytes malignant transformation. Because microRNAs are involved in controlling components of the epigenetic machinery, the aim of this work was to evaluate the potential association between the expression of miR-203, miR-26, and miR-29 family members and the genes Dnmt3a, Dnmt3b, Mecp2, and Ezh2 during cells transformation. Our results show that microRNAs and their validated or predicted targets are inversely expressed, indicating that these molecules are involved in epigenetic reprogramming. We also show that miR-203 downregulates Dnmt3b in mouse melanocyte cells. In addition, treatment with 5-aza-CdR promotes the expression of miR-26 and miR-29 in a nonmetastatic melanoma cell line. Considering the occurrence of CpG islands near the miR-26 and miR-29 promoters, these data suggest that they might be epigenetically regulated in cancer.

  13. Cosmetology 103, 203, 303.

    Science.gov (United States)

    Manitoba Dept. of Education, Winnipeg.

    As part of the high school vocational industrial program in Manitoba, this course has been designed to provide students with the foundation for a career in cosmetology. The program introduces and provides opportunities for student skill development in the techniques of hairdressing, hair cutting, facial preparation, and skin care. The program,…

  14. BCG对小鼠RAW264.7巨噬细胞miR-203、miR-142-3p、miR-21表达的影响%Effect of BCG on expression of miR-203, miR-142-3p and miR-21 in mouse RAW264.7 macrophages

    Institute of Scientific and Technical Information of China (English)

    张兆波; 魏军; 汤建中; 赵志军; 张一琳; 张瑞芹; 徐广贤

    2013-01-01

    目的:检测卡介苗(Bacillus Calmette-Guerin,BCG)刺激巨噬细胞后miR-203、miR-142-3p、miR-21表达量的变化,为研究microRNA(miRNA)在巨噬细胞抗结核分枝杆菌免疫应答中的调控作用提供依据.方法:利用浓度为1.0 ×107ml-1的BCG刺激培养的小鼠RAW264.7细胞,分别在4、8、12、24小时提取细胞small RNA,并利用相应的茎环反转录引物,反转录成cDNA,同时构建成熟miR-203、miR-142-3p、miR-21的T载体,绘制标准曲线,利用Real-Time PCR检测miR-203、miR-142-3p、miR-21的表达量.结果:BCG作用RAW264.7细胞4、8、12、24小时后,miR-21表达显著性上调(10倍以上,P<0.05),miR-142-3p表达显著性下调(20倍以上,P<0.05),miR-203在4、8、12小时表达下调(3倍以上,P<0.05),24小时后表达上调(2倍以上,P<0.05).结论:BCG刺激RAW264.7巨噬细胞后,miR-203、miR-142-3p、miR-21的表达发生显著性变化,说明这些miRNA可能通过调控免疫相关基因在巨噬细胞抗结核分枝杆菌的免疫应答中发挥着重要的作用.%Objective: To detect the influence of Bacillus Calmette-Guerin (BCG) on the expression of miit-203, miR-142-3p and miR-21 in the macrophages and provide the basis to study the regulation of miRNA in the immune response of macrophages to My-cobacterium tuberculosis. Methods:Small RNA was extracted at different times after stimulated with a concentration of 1.0 × 107 ml"1 of BCG in cultured mouse RAW264. 7 cells. After using stem-loop reverse transcription primers to reverse transcribed into cDNA, the expression of miR-203, miR-142-3p and miR-21 was detected by Real-time PCR. At the same time, building the T vector of mature miR-203, miR-142-3p and miR- 21 to make the standard curve. Results:After RAW264.7 cells was treated by BCG for 4, 8, 12 and 24 h, miR-21 expression was up-regulated significantly (More than 10 times, P < 0. 05). However, miR-142-3 p was significantly down-regulated at the same time( More than 20 times, P <0. 05

  15. Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents.

    Science.gov (United States)

    Tiwari, Prakash; Gupta, Krishna P

    2014-07-15

    We investigated the chemopreventive effects of naturally occurring compounds like butyric acid (BA), nicotinamide (NA) and calcium glucarate (CAG) individually or in combination in 7, 12-dimethylbenz [a] anthracene (DMBA) treated mouse skin at 4 and 16 weeks, the time before and after the tumor development. DMBA application did not show any skin tumors at 4 weeks but well defined tumors appeared at 16 weeks. BA, NA or CAG prevented the tumor development significantly but the protection was highly enhanced when all these compounds were given together. In order to see the molecular changes progressing with tumors, we showed the downregulation of tumor suppressor miR-203 at 16 weeks and upregulation of histone deacetylases (HDAC), DNA methyltransferase, promoter methylation of miR-203 at 4 or 16 weeks. Regulators of micro RNA biogenesis such as DICER1 and Ago2 were also deregulated by DMBA. Proto-oncogene c-myc and BMI1 were upregulated and tumor suppressor gene p16 was downregulated by DMBA as a function of time. Effects of BA, NA or CAG were more pronounced after 16 weeks as compared to 4 weeks in preventing the tumor development and altered gene expression. Concomitant administration of BA, NA and CAG tried to prevent these alterations more effectively than that of individual compound possibly by regulating miR-203 status through epigenetic or biogenetic modulations before and after the tumor development. Study provides a rationale for chemoprevention by combination of different compounds targeting miR-203. PMID:24792773

  16. Konica Minolta bizhub C203 the Brand-new Intelligent Color Digital MFP Goes on the Market Brilliantly%柯尼卡美能达全新智能多功能彩色数码复合机bizhub C203精彩上市

    Institute of Scientific and Technical Information of China (English)

    张华

    2008-01-01

    @@ 2008年9月17日,全球彩色商务领导厂商柯尼卡美能达办公系统(中国)有限公司推出功能与设计兼备,迎合高效商务工作组和大中型企业印务需求的彩色多功能数码复合机bizhub C203,其黑白、彩色输出同速,均为20页每分钟.

  17. NITRATE + NITRITE CONTENT (CONCENTRATION), PHOSPHATE, NITRITE, SILICATE and other profile and discrete sample data collected in the Gulf of Alaska on the ALPHA HELIX and WECOMA cruises HX203, HX205 and others as part of the NEP project from 1998-03-08 to 2004-07-05 (NODC Accession 0115260)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0115260 includes profile, discrete sample and chemical data collected aboard the ALPHA HELIX and WECOMA during cruises HX203, HX205, HX208, HX211,...

  18. BIOMASS, SPECIES IDENTIFICATION, SPECIES IDENTIFICATION - LIFE STAGE, TAXONOMIC CODE and species abundance tows data collected in the Gulf of Alaska on the ALPHA HELIX and WECOMA cruises HX201, HX203 and others as part of the NEP project from 1997-10-14 to 2004-10-08 (NODC Accession 0113956)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0113956 includes tows and biological data collected aboard the ALPHA HELIX and WECOMA during cruises HX201, HX203, HX205, HX208, HX211, HX215, HX217,...

  19. BIOMASS, SPECIES IDENTIFICATION, TAXONOMIC CODE, SPECIES IDENTIFICATION - LIFE STAGE and species abundance tows data collected in the Gulf of Alaska on the ALPHA HELIX and WECOMA cruises HX201, HX203 and others as part of the NEP project from 1997-10-10 to 2004-10-07 (NODC Accession 0113896)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0113896 includes tows and biological data collected aboard the ALPHA HELIX and WECOMA during cruises HX201, HX203, HX205, HX208, HX211, HX215, HX217,...

  20. SALINITY, WATER TEMPERATURE, FLUORESCENCE, PHOTOSYNTHETIC ACTIVE RADIATION (PAR) and other profile data collected in the Gulf of Alaska on the ALPHA HELIX and WECOMA cruises HX201, HX203 and others as part of the NEP project from 1997-10-10 to 2004-12-09 (NODC Accession 0113922)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC Accession 0113922 includes profile, biological and physical data collected aboard the ALPHA HELIX and WECOMA during cruises HX201, HX203, HX205, HX208, HX211,...

  1. A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.

    Science.gov (United States)

    Kassa, Jiri; Karasova, Jana Zdarova; Pavlikova, Ruzena; Musilek, Kamil; Kuca, Kamil; Bajgar, Jiri; Jung, Young-Sik

    2011-03-01

    The potency of bispyridinium acetylcholinesterase reactivator KR-22934 in reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic effects was compared with the oxime K203 and commonly used oximes. Studies determining percentage of reactivation of tabun-inhibited blood and tissue acetylcholinesterase in rats showed that the reactivating efficacy of KR-22934 was slightly higher than the reactivating efficacy of K203 and roughly corresponded to the reactivating efficacy of obidoxime and trimedoxime in blood and diaphragm. On the other hand, the oxime KR-22934 was not able to reactivate tabun-inhibited acetylcholinesterase in the brain. The therapeutic efficacy of all oximes studied approximately corresponded to their reactivating efficacy. Based on the results, one can conclude that the oxime KR-22934 is not suitable for the replacement of commonly used oximes for the antidotal treatment of tabun poisoning in spite of its potency to reactivate tabun-inhibited acetylcholinesterase in the peripheral compartment (blood, diaphragm).

  2. Factors Associated with Advanced Inferior Vena Cava Filter Removals: A Single-Center Retrospective Study of 203 Patients Over 7 Years

    Energy Technology Data Exchange (ETDEWEB)

    Dowell, Joshua D., E-mail: Joshua.Dowell@osumc.edu; Wagner, Daniel, E-mail: Daniel.Wagner@osumc.edu; Elliott, Eric, E-mail: Eric.Elliott@osumc.edu [The Ohio State University Wexner Medical Center, Department of Radiology, Division of Interventional Radiology (United States); Yildiz, Vedat O., E-mail: Vedat.Yildiz@osumc.edu; Pan, Xueliang, E-mail: Jeff.Pan@osumc.edu [The Ohio State University Wexner Medical Center, Center for Biostatistics (United States)

    2016-02-15

    PurposeTo identify factors associated with advanced inferior vena cava filter (IVCF) retrieval to raise awareness on technical considerations, retrieval efficiency, and patient safety.Materials and MethodsA single-center retrospective review was performed of 203 consecutive retrievable IVC filters placed between 2007 and 2014. Attempted retrievals were classified as advanced if the routine “snare and sheath” technique was initially unsuccessful after multiple attempts, or an alternate endovascular maneuver or access site was utilized. Patient and filter characteristics were recorded.Results203 attempted retrievals were reviewed (48.7 % male, 51.2 % female, mean age 52.7 years, mean dwell time 109 days). Advanced retrievals were observed in 20 patients (9.8 %) (15 females, 5 males). Fluoroscopy time (p ≤ 0.01, 34.3 ± 21.1 and 5.3 ± 4.5 min for advanced retrievals and routine retrievals respectively, same below), gender (p = 0.031), and retrieval tilt angle (p ≤ 0.01, 5.7 ± 5.10° vs. 11.9 ± 11.03°) were associated with advanced retrievals. Females were 3.16 times more likely to have an advanced retrieval performed than males with a significantly higher tilt angle in those with advanced retrieval. History of cancer (p = 0.502), dwell time (p = 0.916), retrieval caval diameter (p = 0.053), placement caval diameter (p = 0.365), filter type (p = 0.710), strut perforation (p = 0.506), placement tilt angle (p = 0.311), and age (p = 0.558) were not found significantly associated with advanced retrievals.ConclusionsWomen are at increased risk for advanced filter retrieval secondary to a significant change in filter tilt over time compared to men, independent of filter type or competing demographic or filter risks, likely placing them at increased risk for higher procedural fluoroscopy times.

  3. Clinical utility of multiplex ligation-dependent probe amplification technique in identification of aetiology of unexplained mental retardation: A study in 203 Indian patients

    Directory of Open Access Journals (Sweden)

    Vijay R Boggula

    2014-01-01

    Full Text Available Background & objectives: Developmental delay (DD/mental retardation also described as intellectual disability (ID, is seen in 1-3 per cent of general population. Diagnosis continues to be a challenge at clinical level. With the advancement of new molecular cytogenetic techniques such as cytogenetic microarray (CMA, multiplex ligation-dependent probe amplification (MLPA techniques, many microdeletion/microduplication syndromes with DD/ID are now delineated. MLPA technique can probe 40-50 genomic regions in a single reaction and is being used for evaluation of cases with DD/ID. In this study we evaluated the clinical utility of MLPA techniques with different probe sets to identify the aetiology of unexplained mental retardation in patients with ID/DD. Methods: A total of 203 randomly selected DD/ID cases with/without malformations were studied. MLPA probe sets for subtelomeric regions (P070/P036 and common microdeletions/microduplications (P245-A2 and X-chromosome (P106 were used. Positive cases with MLPA technique were confirmed using either fluorescence in situ hybridization (FISH or follow up confirmatory MLPA probe sets. Results: The overall detection rate was found to be 9.3 per cent (19 out of 203. The detection rates were 6.9 and 7.4 per cent for common microdeletion/microduplication and subtelomeric probe sets, respectively. No abnormality was detected with probe set for X-linked ID. The subtelomeric abnormalities detected included deletions of 1p36.33, 4p, 5p, 9p, 9q, 13q telomeric regions and duplication of 9pter. The deletions/duplications detected in non telomeric regions include regions for Prader Willi/Angelman regions, Williams syndrome, Smith Magenis syndrome and Velocardiofacial syndrome. Interpretation & conclusions: Our results show that the use of P245-A2 and P070/P036-E1 probes gives good diagnostic yield. Though MLPA cannot probe the whole genome like cytogenetic microarray, due to its ease and relative low cost it is an

  4. The assessment and control of the implementation of Articles 3 and 7 of EC Directive 80/779/EEC (sulphur dioxide and suspended particulates) and EC Directive 85/203/EEC (nitrogen dioxide) in Luxembourg

    OpenAIRE

    Sluyter RJCF (ed); LLO

    1994-01-01

    De implementatie in de Luxemburgse wetgeving van de EG richtlijnen 80/799 (zwaveldioxide en zwevende deeltjes) en 85/203 (stikstofdioxide) is beschreven in dit rapport. De nadruk hierbij is gelegd op de monitoring van zwaveldioxide, zwevende deeltjes en stikstofdioxide in overeenstemming met de richtlijnen en de controle van de luchtkwaliteit. Informatie over emissies en concentraties van voornoemde stoffen wordt gegeven. Het beleid van Luxemburg inzake de vermindering van luchtverontreinigin...

  5. TSP-203超前地质预报在隧道斜井涌水探测中的应用%On the Application of the TSP-203 Advanced Geological Forecasting to the Detection of Water Inflow in Inclined Shafts for a Tunnel

    Institute of Scientific and Technical Information of China (English)

    蔡永斐

    2015-01-01

    介绍了TSP-203超前地质预报探测技术的工作原理、系统组成,现场数据采集的程序及在此过程中应注意的问题等;结合在斜井涌水探测中的应用实例,进行了具体的数据解译,并据此预测了可能发生涌水的位置,并及时启动了应急预案,成功的完成了斜井的开挖施工.可为隧道施工超前地质预报工作提供参考.

  6. 雄甾-4-烯-3,17-二酮11α羟化突变株Metarhizium anisopliae M28-203的代谢调控%Metabolic regulation of androst-4-ene-3,17-dione 11α-hydroxylation mutant strain Metarhizium anisopliae M28-203

    Institute of Scientific and Technical Information of China (English)

    叶丽; 周珮; 冯美卿

    2011-01-01

    目的 从营养代谢调控和转化条件控制两个方面入手提高雄甾-4-烯-3,17-二酮(androst-4-ene-3,17-dione,AD)11α羟化突变株Metarhizium anisopliae M28-203转化效率.方法 通过正交试验确定发酵培养基配方,对影响转化的一系列因素如:pH、发酵时间、通气量、底物投料量及溶解性、细胞通透性进行控制,考察以上因素对羟化反应的影响,确定最佳转化条件.结果 该突变株培养基最佳配方为葡萄糖30 g/L、玉米浆20 g/L、蚕蛹粉5 g/L、硫酸铵2.5 g/L、磷酸氢二钾1 g/L、硫酸镁0.5 g/L和硫酸亚铁0.02 g/L.在pH 6.0~6.5、菌龄48~60 h、250 mL摇瓶装液量为30和40 mL、转化时间72 h时能取得最佳转化效果.在底物投料量为2 mg/mL时,采用4%无水乙醇溶解底物或加入0.75 mg/mL Tween 80均有利于羟化反应,在以上优化条件下转化率分别达到62.5%和66.8%.结论 突变株Metarhizium anisopliae M28-203能有效地在AD上引入11α羟基,为工业生产依普利酮及其他甾体药物提供关键中间体.%Objective To improve the transformation efficiency of androst-4-ene-3, 17-dione (AD) llα-hydroxylation mutant strain Metarhizium anisopliae M28-203 through regulations of nutrition metabolism and biotransformation conditions. Methods The optimal fermentation culture was determined by orthogonal test. The effects of pH, fermentation time, air flow, substrate addition method and substrate concentration on hydroxylation were investigated and the optimal transformation condition was constructed. Results The optimal fermentation culture contained glucose 30 g/L, corn steep 20 g/L, silkworm chrysalis powder 5 g/L, (NH4)2SO4 2.5 g/L, K2HPO4 1 g/L, MgSO4 0.5 g/L and FeSO4 0.02 g/L. The optimal transformation condition was pH 6.0 - 6.5, 48 - 60 h mycelium age, 30 and 40 mL medium volume in 250 mL shake flask and 72 hour transformation time. Both 4% ethanol and 0.75 mg/mL Tween 80 were helpful for substrate solubility, and then

  7. /sup 99m/pertechnetate uptake in the transplanted kidney. [/sup 99m/Tc, /sup 133/Xe, /sup 131/I, /sup 203/Hg

    Energy Technology Data Exchange (ETDEWEB)

    Aquino, H.C.; Preston, D.F.; Luke, R.G.

    1971-01-01

    Acute renal failure is a common complication of kidney transplantation. The major causes are acute tubular necrosis (ATN), arterial or venous thrombosis, rejection, ureteral obstruction, and extravasation. Each situation requires a different treatment and demands prompt diagnosis to prevent loss of the graft and patient morbidity or mortality. The clinical problem is further complicated by the possible coincidence of more than one of these pathologies, in particular the development of graft rejection superimposed on ATN in the post-transplant period. The diagnostic studies used in this differential diagnosis may include retrograde ureteral catheterization, renal arteriography, open or closed renal biopsy, isotope studies with /sup 133/xenon, /sup 131/I-hippuran, /sup 203/Hg-chlormerodrin, and more recently /sup 99m/pertechnetate. Only the latter methods with hippuran, chlormerodrin, and pertechnetate avoid direct manipulation of the graft or its artery or ureter with the inherent risks of such procedures. We present results of serial studies of sodium /sup 99m/pertechnetate photoscanning(Tc scan) in 38 renal homografts. In some studies computer determined graphs of renal radioactivity versus time (Tc renogram) were obtained.

  8. Estrategias de enseñanza para el curso EIF-203 Estructuras discretas para informática a través del uso de las redes sociales Facebook y Twitter

    Directory of Open Access Journals (Sweden)

    Enrique Vílchez Quesada

    2014-05-01

    Full Text Available Recibido 29 de octubre de 2013 • Corregido 2 de marzo de 2014 • Aceptado 2 de abril de 2014. Este artículo corresponde a un trabajo científico derivado del proyecto de investigación en docencia adscrito a la Escuela de Informática de la Universidad Nacional de Costa Rica (UNA, titulado: Facebook como herramienta de enseñanza y aprendizaje para el curso EIF-203 Estructuras discretas para informática a través del uso de cuadernos interactivos. El objetivo general del proyecto consistió en analizar técnica y pedagógicamente la red social Facebook como un entorno de enseñanza y aprendizaje. En este documento se presenta una serie de estrategias de enseñanza creadas para complementar la docencia en el contexto del curso EIF-203, utilizando como plataforma educativa las redes sociales Facebook y Twitter. Las estrategias compartidas constituyen una intensa búsqueda de nuevas metodologías para mejorar los procesos de enseñanza e, idealmente, los procesos de aprendizaje en la materia EIF-203, integrada dentro del plan de estudios de la carrera Ingeniería en Sistemas de Información de la UNA. Estas fueron implementadas en un grupo de 31 estudiantes de la Sede Interuniversitaria de Alajuela, durante el I semestre 2013. Lo anterior permitió evaluar las estrategias de enseñanza desarrolladas utilizando una metodología de carácter cuantitativo. El instrumento empleado (un cuestionario se validó mediante una prueba de fiabilidad “Alfa de Cronbach” recurriendo a una muestra de 65 participantes. Los resultados obtenidos forman parte del análisis expuesto en el presente trabajo.

  9. Simulation and optimization of the tower in a commercial vinyl acetate refining process%醋酸乙烯精制工艺中TQ-203塔的参数模拟优化与技术改造

    Institute of Scientific and Technical Information of China (English)

    李群生; 徐曼; 陈刚; 黄荣海; 徐凌云; 王宝华

    2013-01-01

    This paper targets the problem of handling capacity not meeting the production requirements and the high energy consumption in tower TQ-203 in a commercial vinyl acetate refining process.The process simulation software Aspen Plus was used simulate the vinyl acetate distillation tower,and the NRTL model which was close to the actual production parameters was selected.The number of theoretical plates used was 31.Orthogonal experimental analysis methods were used to obtain the best combination of the parameters to improve the design and operation parameters:the best location of the feed was found to be the 5 th theoretical plate,with a reflux ratio of 2.30,and the side cutting position at the 29th theoretical plate.Using the above parameters resulted in improvements and the production requirements being met.Two energy-saving measures including preheating the feed on the tower side and the side draw of TQ-205 heating the tower reactor of TQ-203 were proposed,which could reduce vapor (0.4 MPa) flow to 12.56 t/h and circulating cooling water flow to 434.54 t/h,resulting in economic benefits of 14.95 million yuan/a.%针对某工厂醋酸乙烯精制工艺TQ-203塔存在处理量不能满足生产要求、能耗较高的问题,运用流程模拟软件Aspen Plus对TQ-203塔进行模拟,选取最接近生产实际的NRTL模型,确定了理论板数为31块.由单因素分析给出了较优的参数范围,利用正交实验方法得到的最佳参数组合为:进料位置为第5块理论板,回流比为2.30,侧线采出位置为第29块理论板.根据上述结果提出对TQ-203塔更换塔板、调整进料及侧线采出位置的改进措施,能够满足该塔对处理量及产品纯度的生产要求;提出了侧线采出预热进料和采用第五精馏塔侧线采出做本塔塔釜热源的节能措施,该措施能节省水蒸汽(0.4MPa)12.56t/h、循环冷却水434.54t/h,可取得经济效益1495万元/a.

  10. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  11. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  12. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  13. Study and construction of a β-spectrometer of uniform axial magnetic field fitted with a β-γ coincidence selector. Study of the β spectra of 32P, 203Hg, 198Au. Measurement of the conversion coefficients of 203Ti and of 198Hg

    International Nuclear Information System (INIS)

    In the first part is given the principle of the beta spectrometer with uniform axial field using systematically the idea of caustics. The apparatus is described and its properties compared to those deduced from trajectory calculations. The β-ray and γ-ray detectors and the device for selecting coincidences with a 2 τ resolution of 5 nanoseconds are also presented. In the second part, the spectrometer is used for studying reference elements and the most accurate results are confirmed. The β spectrum of 60Co has a statistical form with an accuracy of 1 per cent; the maximum energy E0 is 316.5 ± 1.5 keV. That of the 7/2 + → 11/2 transition for 137Cs has a unique form, once forbidden. E0= 522 ± 3 keV. Conversion coefficients αk = 96 ± 1 X 10-3 αL + M + N = 20.9 ± 0.5 X 10-3. The two β spectra of 59Fe, separated by coincidence with the gamma, have the statistical form E0 = 462 ± 2 keV (55.1 + 0,3 per cent) and E1 = 275 ± 4 keV (44.9 ± 0.3 per cent). It is then verified whether the l selection rule is apparent in the shape of the phosphorus 32 beta spectrum. It is found in fact that it is not of statistical shape and its shape coefficient is determined. For a theoretical interpretation it is necessary to have better approximations than those generally used and this interpretation will not be unique. This work has also made it possible to show that the source contains a small proportion of 33P. The study of the 203Hg β spectrum followed by the 279 keV gamma spectrum is designed to determine the conversion coefficients. The interior spectrum of gold 198 is not of statistical shape either. The form coefficient is determined together with the conversion coefficients which are in slight disagreement with those calculated by Rose or Sliv. An interpretation of the spectrum is put forward which proposes an imperfect compensation for the various elements of the matrix. (author)

  14. Mead acid (20:3n-9) and n-3 polyunsaturated fatty acids are not associated with risk of posterior longitudinal ligament ossification: results of a case-control study.

    Science.gov (United States)

    Hamazaki, Kei; Kawaguchi, Yoshiharu; Nakano, Masato; Yasuda, Taketoshi; Seki, Shoji; Hori, Takeshi; Hamazaki, Tomohito; Kimura, Tomoatsu

    2015-05-01

    Ossification of the posterior longitudinal ligament (OPLL) involves the replacement of ligamentous tissue with ectopic bone. Although genetics and heritability appear to be involved in the development of OPLL, its pathogenesis remains to be elucidated. Given previous findings that 5,8,11-eicosatrienoic acid [20:3n-9, Mead acid (MA)] has depressive effects on osteoblastic activity and anti-angiogenic effects, and that n-3 polyunsaturated fatty acids (PUFAs) have a preventive effect on heterotopic ossification, we hypothesized that both fatty acids would be involved in OPLL development. To examine the biological significance of these and other fatty acids in OPLL, we conducted this case-control study involving 106 patients with cervical OPLL and 109 age matched controls. Fatty acid composition was determined from plasma samples by gas chromatography. Associations between fatty acid levels and incident OPLL were evaluated by logistic regression. Contrary to our expectations, we found no significant differences between patients and controls in the levels of MA or n-3 PUFAs (e.g., eicosapentaenoic acid and docosahexaenoic acid). Logistic regression analysis did not reveal any associations with OPLL risk for MA or n-3 PUFAs. In conclusion, no potential role was found for MA or n-3 PUFAs in ectopic bone formation in the spinal canal. PMID:25669698

  15. Acute stressor exposure modifies plasma exosome-associated heat shock protein 72 (Hsp72 and microRNA (miR-142-5p and miR-203.

    Directory of Open Access Journals (Sweden)

    Lida A Beninson

    Full Text Available Exosomes, biologically active nanoparticles (40-100 nm released by hematopoietic and non-hematopoietic cells, contain a variety of proteins and small, non-coding RNA known as microRNA (miRNA. Exposure to various pathogens and disease states modifies the composition and function of exosomes, but there are no studies examining in vivo exosomal changes evoked by the acute stress response. The present study reveals that exposing male Fisher 344 rats to an acute stressor modulates the protein and miRNA profile of circulating plasma exosomes, specifically increasing surface heat shock protein 72 (Hsp72 and decreasing miR-142-5p and -203. The selected miRNAs and Hsp72 are associated with immunomodulatory functions and are likely a critical component of stress-evoked modulation of immunity. Further, we demonstrate that some of these stress-induced modifications in plasma exosomes are mediated by sympathetic nervous system (SNS activation of alpha-1 adrenergic receptors (ADRs, since drug-mediated blockade of the receptors significantly attenuates the stress-induced modifications of exosomal Hsp72 and miR-142-5p. Together, these findings demonstrate that activation of the acute stress response modifies the proteomic and miRNA profile of exosomes released into the circulation.

  16. IgG三羰基锝[99mTc(CO)3(H20)3+]标记方法及其在动物体内的生物学分布%IgG radiolabelling with 99mTC by tricarbonyl method and its biodistribution in mice

    Institute of Scientific and Technical Information of China (English)

    池晓华; 黄宝丹; 汪兵; 黄凯; 李贵平

    2010-01-01

    目的 探索利用fac[99mTC(CO)3(H20)3]+中间体标记IgG的方法,了解99mTc(CO)3(H20)3-IgG在体内外的稳定性,并研究其在小鼠体内的生物分布情况.方法 自行合成fac-(99mTc(CO)3(H20)3]+中间体,并采用聚酰胺薄膜层析法测定其放化产率,利用放化中间体fac-[99mTc(CO)3(H20)3]+直接进行IgG的放射性标记,用纸层析法测定标记率及放化纯度.并分别观察99mTc标记IgG在人血清白蛋白(HSA)及生理盐水(NS)中的稳定性.取9只小白鼠,分别经尾静脉注人99mTc 标记IgG(3.7x104 Bq/100μl),于注药后2,4和12h分别先进行SPECT显像,然后处死小鼠分离各脏器,称重后测定放射性计数,计算各脏器每克组织百分注射剂量(%ID/g),结果fac-[99mTc(CO)3(H2O)3]+中间体的放化产率为82.48%,室温放置4h保持稳定.99mTc(CO)3(H20)3-IgG的标记率为57.04%,放化纯度均大于90%,在HSA中温育24h放化纯度保持稳定,而在NS中温育24h放化纯度则降为20%.体内生物分布显示99mTc(CO)3(H20)3-IgG在体内主要分布于肝、脾、肾,可较长时间存留于血池中.结论 利用放化中间体fac-[99mTc(CO)3(H20)3]+直接进行IgG放射性标记,具有良好的体内、外稳定性,在小鼠组织中分布特点符合IgG体内的放射性分布规律,可满足进一步的单抗及多肽标记的实验要求.

  17. Effect of proton irradiation induced defects on intergranular and intragranular pinning in polycrystalline textured Bi2Sr2CaCu2O8+δ and Bi1.84Pb0.34Sr1.91Ca2.03Cu3.06O10+δ superconductors

    International Nuclear Information System (INIS)

    Proton irradiated polycrystalline textured Bi2Sr2CaCu2O8+δ (Bi-2212) and Bi1.84Pb0.34Sr1.91 Ca2.03Cu3.06 O10+δ(Bi-2223) samples have been studied with respect to pinning and its correlation with irradiation induced defects characterised by Positron annihilation spectroscopy. Intergranular and intragranular pinning behaviours have been analysed through minor and major hysteresis loops respectively in DC magnetization at different fields. The sharp fall in the critical current density (Jco) at high dose of Bi-2223 as compared to Bi-2212 has been observed. (author)

  18. 21 CFR 131.203 - Lowfat yogurt.

    Science.gov (United States)

    2010-04-01

    ... culturing is completed, to destroy viable microorganisms. (b) Vitamin addition (optional). (1) If added, vitamin A shall be present in such quantity that each 946 milliliters (quart) of the food contains not...) If added, vitamin D shall be present in such quantity that each 946 milliliters (quart) of the...

  19. 33 CFR 203.32 - Policy.

    Science.gov (United States)

    2010-07-01

    ... Emergency Management Agency (FEMA) has been requested to make an emergency or disaster declaration; a.... All Corps activities will be coordinated with the State Emergency Management Agency or equivalent... Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE...

  20. 48 CFR 16.203-2 - Application.

    Science.gov (United States)

    2010-10-01

    ... covered separately in the contract. Price adjustments based on established prices should normally be restricted to industry-wide contingencies. Price adjustments based on labor and material costs should be... clause. (b) In contracts that do not require submission of certified cost or pricing data,...

  1. 10 CFR 600.203 - Applicability.

    Science.gov (United States)

    2010-01-01

    ...), Alcohol and Drug Abuse Treatment and Rehabilitation Block Grant and part C of Title V, Mental Health... Budget Reconciliation Act of 1981 (Community Services; Preventive Health and Health Services; Alcohol, Drug Abuse, and Mental Health Services; Maternal and Child Health Services; Social Services;...

  2. 37 CFR 203.3 - Organization.

    Science.gov (United States)

    2010-07-01

    ... regulations. The Office of the Register of Copyrights includes the legal, administrative, and automation staff... Copyright Office's home page is: http://www.loc.gov/copyright; information may also be accessed by connecting to the Library of Congress' home page on the World Wide Web. The address is:...

  3. 5 CFR 430.203 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... aspect of individual, team, or organizational performance that is not a critical or non-critical element. Such elements are not used in assigning a summary level but, like critical and non-critical elements... title 5, United States Code, and this subpart. Critical element means a work assignment...

  4. 15 CFR 970.203 - Exploration plan.

    Science.gov (United States)

    2010-01-01

    ... feasibility of commercial scale operations based on technical, economic, legal, political and environmental..., seafloor geotechnic properties, and currents); (5) A general description of the developing recovery and... as discussed in § 970.602; (7) Measures to protect the environment and to monitor the...

  5. 33 CFR 203.46 - Restrictions.

    Science.gov (United States)

    2010-07-01

    ... EMERGENCY EMPLOYMENT OF ARMY AND OTHER RESOURCES, NATURAL DISASTER PROCEDURES Rehabilitation Assistance for Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program..., recreation, fish and wildlife enhancement, land reclamation, habitat restoration, drainage, bank...

  6. 42 CFR 37.203 - Autopsy specifications.

    Science.gov (United States)

    2010-10-01

    ... shall be measured directly above the insertion of the anterior papillary muscle; (v) Size, number... block of tissue; a minimum of three stained slides and three blocks of tissue shall be submitted. When...-impregnated blocks of tissue shall be submitted. (b) Needle biopsy techniques shall not be used....

  7. 5 CFR 179.203 - Definitions.

    Science.gov (United States)

    2010-01-01

    ...) Health insurance premiums; (8) Normal retirement contributions as explained in 5 CFR 581.105(e) (e.g... Plan); and (9) Normal life insurance premiums (e.g., Serviceman's Group Life Insurance and basic Federal Employee's Group Life Insurance premiums) exclusive of optional life insurance......

  8. 14 CFR 417.203 - Compliance.

    Science.gov (United States)

    2010-01-01

    ... for any change to the flight safety analysis method. A licensee must file any material change with the... safety analysis must also meet the requirements for methods of analysis contained in appendices A and B of this part for a launch vehicle flown with a flight safety system and appendices B and C of...

  9. 24 CFR 904.203 - Planning.

    Science.gov (United States)

    2010-04-01

    ... close working relationship with the LHA and a program for phasing in LHA staff who will have the on... indigenous trainers to insure good communication and rapport. Special attention shall be directed to the needs of working members of the family for counseling and training sessions to be held where and...

  10. 23 CFR 620.203 - Procedures.

    Science.gov (United States)

    2010-04-01

    ... standards for the facility involved; (3) That the release will not adversely affect the Federal-aid highway... order to restore, preserve, or improve the scenic beauty adjacent to the highway consonant with...

  11. 21 CFR 333.203 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... lives upon the skin or in the hair or nails. (d) Fungus. Any of a large division of plants, including..., inner thighs and sometimes extends to the groin and the pubic area; the condition most frequently...

  12. 21 CFR 203.3 - Definitions.

    Science.gov (United States)

    2010-04-01

    ..., data, audio, pictorial, or other information representation in digital form that is created, modified... acutely ill or injured persons; provision of minimal emergency supplies of drugs to nearby nursing homes...' and distributors' warehouses, chain drug warehouses, and wholesale drug warehouses;...

  13. 21 CFR 203.22 - Exclusions.

    Science.gov (United States)

    2010-04-01

    ... purchase or other acquisition of a drug for its own use by a hospital or other health care entity that is a... the act and this part applicable to a wholesale distributor or retail pharmacy. (i) The sale, purchase... pharmacy....

  14. 47 CFR 13.203 - Examination elements.

    Science.gov (United States)

    2010-10-01

    ... other appropriate means the number of questions to be included in the question pool, the number of questions to be included in the examination, and the number of questions that must be answered correctly to... specialized theory and practice applicable to the proper installation, servicing and maintenance of ship...

  15. 50 CFR 223.203 - Anadromous fish.

    Science.gov (United States)

    2010-10-01

    ... Natural Resources (WDNR) finds that the alternate plans protect physical and biological processes at least... apply to fishery harvest activities provided that: (i) Fisheries are managed in accordance with a NMFS... concurrence from NMFS. NMFS will approve an FMEP only if it clearly defines its intended scope and area...

  16. 5 CFR 2640.203 - Miscellaneous exemptions.

    Science.gov (United States)

    2010-01-01

    ... pertinent to the case, the employee learns that the mutual life insurance company from which he holds a life... employer other than as part of a class. For purposes of this paragraph, “disqualifying financial interest... arising from the ownership of stock in his employer or prospective employer. Example 1: A chemist...

  17. 50 CFR 665.203 - Permits.

    Science.gov (United States)

    2010-10-01

    .... If one or more persons on a vessel-based bottomfish fishing trip holds an MHI non-commercial permit... fishing occurs during or as a result of a vessel-based fishing trip, then the fishing trip is considered... incapacitation, vessel breakdowns, and the loss of the vessel at sea if the event prevented the vessel...

  18. 24 CFR 203.673 - Habitability.

    Science.gov (United States)

    2010-04-01

    ... equipment used in the residential unit; (iii) Adequate cooking facilities; (iv) A continuing supply of hot and cold water; and (v) Adequate sanitary facilities and a safe method of sewage disposal. (2)...

  19. 40 CFR 211.203 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS PRODUCT NOISE... acoustic enclosures which fit over the ears and which are held in place by a spring-like headband to which... interchangeably with -the terms, “hearing protector” and -“device.” (n) Impulsive Noise. An acoustic...

  20. 31 CFR 203.2 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... located for purposes of Regulation D (12 CFR 204.3(b)(2)), even if the financial institution is not... instructions. ACH debit entry means a debit transaction originated by the Treasury Financial Agent (TFA), at.... Treasury Financial Agent (TFA) means a financial institution designated as an agent of Treasury...

  1. 24 CFR 203.672 - Residential areas.

    Science.gov (United States)

    2010-04-01

    ... used by persons active in the real estate industry in the affected area. (b) HUD shall establish such... constitutes a local economic market for the purchase and sale of residential real estate. In...

  2. 47 CFR 20.3 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... requires the use of special location-determining hardware and/or software in a portable or mobile phone. Handset-based location technology may also employ additional location-determining hardware and/or software... of providing the location of wireless 911 callers that employs hardware and/or software in the...

  3. 15 CFR 20.3 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... providing education, health care, housing, social services, or parks and recreation; or (ii) The entire... insurance or guaranty), or any other arrangement by which the agency provides or otherwise makes available...)(i) A college, university, or other postsecondary institution, or a public system of higher...

  4. 1 CFR 20.3 - Organization.

    Science.gov (United States)

    2010-01-01

    ... the agency's organizational structure. Charts must be prepared so as to be perfectly legible when... relationships between units. (c) Narrative descriptions of organizational structure or hierarchy that...

  5. 12 CFR 203.2 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... Consumer Price Index for Urban Wage Earners and Clerical Workers, not seasonally adjusted, for each twelve... home purchase loan (excluding temporary financing such as a construction loan) or refinancing of a home... defined in Regulation Z (Truth in Lending), 12 CFR part 226. (g) Home improvement loan means: (1) A...

  6. 49 CFR 232.203 - Training requirements.

    Science.gov (United States)

    2010-10-01

    ... training curriculum that covers the skills and knowledge the employee will need to possess in order to... satisfaction of the employee's supervisor or designated instructor; (6) An employee hired or working prior to... if the employee receives training and testing on the specific Federal regulatory...

  7. 28 CFR 42.203 - Discrimination prohibited.

    Science.gov (United States)

    2010-07-01

    ... on Employee Selection Guidelines, 28 CFR 50.14. (c) In matters involving employment discrimination... Guidelines on Employee Selection Procedures, 28 CFR 50.14. (e) A recipient, in determining the type of... summary punishment, or deny any individual the rights guaranteed by the Constitution to all persons;...

  8. 40 CFR 90.203 - General provisions.

    Science.gov (United States)

    2010-07-01

    ... should have reason to believe that such engines have been or will be imported in a piece of equipment; or... Enforcement Audit (SEA) failure, credits may be used to cover subsequent production of engines for the...

  9. 47 CFR 90.203 - Certification required.

    Science.gov (United States)

    2010-10-01

    ... States after March 15, 1988. Marketing of these transmitters shall not be permitted after March 15, 1989... capability to be programmed for operation on the mutual aid channels as designated in § 90.617(a)(1) of the... is capable of operating on the nationwide public safety interoperability calling channel in the...

  10. 48 CFR 31.203 - Indirect costs.

    Science.gov (United States)

    2010-10-01

    ... contract or other work, indirect costs are those remaining to be allocated to intermediate or two or more... basis of the benefits accruing to intermediate and final cost objectives. When substantially the same... for allocating indirect costs is the cost accounting period during which such costs are incurred...

  11. The study of inter and intragranular pinning behavior of oxygen irradiated textured polycrystalline Bi2Sr2CaCu2O8+δ and Bi1.84Pb0.34Sr1.91Ca2.03Cu3.06O10+δ superconductors

    International Nuclear Information System (INIS)

    Inter and intragranular pinning potentials of 116 MeV oxygen ion irradiated textured polycrystalline Bi2Sr2CaCu2O8+δ (Bi-2212) and Bi1.84Pb0.34Sr1.91Ca2.03Cu3.06O10+δ (Bi-2223) have been studied from dc magnetization at low (50 Oe) and high (10,000 Oe) fields respectively. There is an increase in intergranular pinning potential (U0) in Bi-2223 in contrast to anomalous decreases in Bi-2212 with increasing dislocation density. Intragranular pinning potential is governed by the concentration of vacancy type defects rather than its size as observed in proton irradiation. Pinning has been explained in the light of statistical dilute pinning model

  12. A Search for Lepton-Flavor-Violating Decays of the 125 GeV Higgs Boson with Hadronically Decaying Tau Leptons in the 20.3 fb$^{-1}$, $\\sqrt{s} = 8$ TeV Dataset Collected in 2012 by the ATLAS Detector at the Large Hadron Collider

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00287453

    This dissertation presents a search for lepton-flavor-violating (LFV) decays of the 125 GeV Higgs boson in final states of $\\mu\\tau_{\\mathrm{had}}$ and $e\\tau_{\\mathrm{had}}$ in the full dataset collected by the ATLAS detector in 2012. The search is based on data samples of proton--proton collisions at $\\sqrt{s} = 8$ TeV, corresponding to an integrated luminosity of 20.3 fb$^{-1}$. The topology of LFV events is exploited through an optimized selection of objects and events, with signal and control regions defined by event kinematics. A binned likelihood fit searching for the presence of LFV Higgs decays is performed using the reconstructed Higgs boson mass as the discriminating variable. No such decays are observed. The expected (observed) upper limits at $95\\%$ confidence on the branching ratios for the muon and electron final states are found to be $\\mathrm{Br}(H \\rightarrow \\mu\\tau) = 1.24\\%~(1.85\\%)$ and $\\mathrm{Br}(H \\rightarrow e\\tau) = 2.07\\%~(1.81\\%)$.

  13. The study of inter and intragranular pinning behavior of oxygen irradiated textured polycrystalline Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub 8+{delta}} and Bi{sub 1.84}Pb{sub 0.34}Sr{sub 1.91}Ca{sub 2.03}Cu{sub 3.06}O{sub 10+{delta}} superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Sen, Pintu; Bandyopadhyay, S.K.; Nambissan, P.M.G.; Ganguly, R.; Barat, P.; Mukherjee, P

    2004-08-01

    Inter and intragranular pinning potentials of 116 MeV oxygen ion irradiated textured polycrystalline Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub 8+{delta}} (Bi-2212) and Bi{sub 1.84}Pb{sub 0.34}Sr{sub 1.91}Ca{sub 2.03}Cu{sub 3.06}O{sub 10+{delta}} (Bi-2223) have been studied from dc magnetization at low (50 Oe) and high (10,000 Oe) fields respectively. There is an increase in intergranular pinning potential (U{sub 0}) in Bi-2223 in contrast to anomalous decreases in Bi-2212 with increasing dislocation density. Intragranular pinning potential is governed by the concentration of vacancy type defects rather than its size as observed in proton irradiation. Pinning has been explained in the light of statistical dilute pinning model.

  14. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE,CERN

    OpenAIRE

    Rothe, Sebastian

    2012-01-01

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spec...

  15. Neurocognition and Function of Social Life Investigation among HIV/AIDS Subjects Infected by Plasma Donation%203例农村有偿献血感染人类免疫缺陷病毒者的神经认知及社会生活功能

    Institute of Scientific and Technical Information of China (English)

    石川; Igor GRANGT; Robert K.HEATON; 于欣; 梁英; 陈玉芳; 吴尊友; JIN Hua; Ofilio VIGIL; Lucette A.CYSIQUE; Donald R.FRANKLIN Jr

    2009-01-01

    目的:调查通过献血途径感染人类免疫缺陷病毒(Human immunodeficiency virus,HIV)的203例患者的神经认知状况和社会生活功能.方法:横断面研究,采用神经心理成套测验和日常生活能力量表对安徽阜阳203例通过献血途径感染HIV的患者进行调查,选取198例年龄、性别和受教育年限相匹配的HIV阴性献血者为对照.神经心理成套测验包括执行功能、词语流畅、学习、记忆、精细运动、信息处理速度和工作记忆7个认知领域.以总体缺陷分≥0.5分作为认知损害的划界分.结果:HIV阳性受试总体认知功能[(45.7±5.9) vs.(49.4±6.0),P<0.01]和7个认知领域都较HIV阴性受试差.在精细运动功能方面HIV与丙型肝炎病毒(Heptitis C virus,HCV)感染存在交互作用(F=5.28,P<0.05).临床无症状期的HIV感染者和获得性免疫缺陷综合征(Acquired Immune Deficiency Syndrome,AIDS)患者认知损害率分别为29.2%和43.0%.HIV阳性受试的日常生活能力下降得分高于HIV阴性受试[(0.49±1.32 vs.(0.14±0.75),P<0.01],工作月数、个人和家庭月收入少于HIV阴性受试(P<0.01).认知损害组患者最低CD4细胞计数低于非认知损害组[(214.3±144.0) vs.(274.8±161.1),P=0.010],日常生活能力下降更明显[(0.75±1.58)vs.(0.34±1.13,) P<0.01].总体认知功能和日常生活能力下降相关(r=-0.22,P<0.01).结论:HIV感染者7个神经认知领域均有损害,合并丙型肝炎病毒感染可加重精细运动功能损害,随着疾病进展认知损害率提高;HIV感染者日常生活能力下降、职业功能和经济收入更差.最低CD4细胞计数对神经认知功能受损有一定预测作用;神经认知功能对日常生活能力下降造成一定影响,进而影响个人和家庭的经济收入.%Objective:To investigate the neurocognition and function of social life among human immunodeficiency virus (HIV) positive subjects infected by plasma donation.Methods:Totally 203 HIV positive

  16. 49 CFR 172.203 - Additional description requirements.

    Science.gov (United States)

    2010-10-01

    .... (2) A description of the physical and chemical form of the material, if the material is not in special form (generic chemical description is acceptable for chemical form). (3) The activity contained in... prescribed in the applicable International Atomic Energy Agency (IAEA) Certificate of Competent...

  17. 24 CFR 599.203 - Basic application submission requirements.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES RENEWAL COMMUNITIES Procedures for Nomination of... notice of, and an opportunity to participate in, the application development process. Notice...

  18. 37 CFR 203.4 - Methods of operation.

    Science.gov (United States)

    2010-07-01

    .... and 5 p.m. on any working day except legal holidays at Room LM-401, The James Madison Memorial... for records within twenty (20) working days of receipt by the Supervisory Copyright Information... extension of time greater than ten (10) working days is necessary to respond to a request due to...

  19. 28 CFR 55.6 - Coverage under section 203(c).

    Science.gov (United States)

    2010-07-01

    ... THE VOTING RIGHTS ACT REGARDING LANGUAGE MINORITY GROUPS Nature of Coverage § 55.6 Coverage under... citizens are members of a single language minority group and are limited-English proficient; and (ii) The illiteracy rate of such language minority citizens in the political subdivision is higher than the...

  20. Dicty_cDB: SHL203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available C8, complete sequence. 48 0.39 1 DY882957 |DY882957.1 AresSEQ12202 Amorphotheca resina...e pBluescript (EcoRI-XhoI) Amorphotheca resinae cDNA clone AresSEQ12202, mRNA sequence. 46 1.5 1 dna up

  1. 24 CFR 203.389 - Waived title objections.

    Science.gov (United States)

    2010-04-01

    ... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES... therewith; (k) Violations of cost or set back restrictions which do not provide a penalty of reversion...

  2. 20 CFR 429.203 - When is a claim allowable?

    Science.gov (United States)

    2010-04-01

    ... paragraph (a) of this section and the other provisions of this subpart, any claim you make for damage to, or... excluded under this subpart: (1) Property damage in quarters or other authorized places. Claims are allowable for damage to, or loss of, property arising from fire, flood, hurricane, other natural...

  3. 26 CFR 601.203 - Offers in compromise.

    Science.gov (United States)

    2010-04-01

    ... penalty and the District Counsel concurs in the acceptance of the offer, or (iv) Recommend to the Regional Commissioner the acceptance of the offer if it involves a civil liability of $100,000 or over. (2)(i) If the... acceptance or rejection of the offer together with the examining officer's report of the investigation....

  4. 48 CFR 552.203-71 - Restriction on Advertising.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Restriction on Advertising... Restriction on Advertising. As prescribed in 503.570-2, insert the following clause: Restriction on Advertising (SEP 1999) The Contractor shall not refer to this contract in commercial advertising or...

  5. 48 CFR 852.203-70 - Commercial advertising.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Commercial advertising... Commercial advertising. As prescribed in 803.570-2, insert the following clause: Commercial Advertising (JAN... solicitation, he/she will not advertise the award of the contract in his/her commercial advertising in such...

  6. 48 CFR 4.203 - Taxpayer identification information.

    Science.gov (United States)

    2010-10-01

    ... Representations and Certifications—Commercial Items, the contracting officer shall, unless otherwise provided in... the contract sent to the payment office. (b) If the TIN or type of organization is derived from a... type of organization, unless this information is otherwise provided to the payment office in...

  7. 47 CFR 25.203 - Choice of sites and frequencies.

    Science.gov (United States)

    2010-10-01

    ... strength (mV/m) Power flux density 1 (dBW/m2) Below 540 kHz 10 −65.8 540 to 1600 kHz 20 −59.8 1.6 to 470... shall conform to the power flux density limits at the earth's surface specified in appropriate parts of... data which indicates whether the field strength or power flux density figures in the above table...

  8. Preface: phys. stat. sol. (a) 203/4

    Science.gov (United States)

    Kittler, Martin; Yang, Deren

    2006-03-01

    This issue of physica status solidi (a) contains the majority of papers presented at the 2nd Sino-German Symposium The Silicon Age which was held at the Lindner Hotel Cottbus, Germany, 19-24 September 2005. This meeting followed the 1st Symposium Progress in Silicon Materials held in June 2002 in Hangzhou, P.R. China. 8 Chinese and 14 German scientists from universities, research institutes and industry were invited to present their views about different aspects of silicon.There was a continuous progress in silicon materials development during the last 40-50 years, driven by the need of the IC industry for better and larger monocrystalline silicon wafers. Moreover, low-cost crystalline silicon now dominates the world's production of solar cells in the photovoltaics industry. Furthermore, there are intensive research activities worldwide for on-chip integration of Si-based photonics in CMOS technology. In addition, new areas being connected with silicon are starting to appear, namely Si-based biochips and nanoelectronics. Silicon, one can reasonably argue, is already the most investigated of all materials. However, there is still a need for continuation of research and development regarding numerous aspects of Si and also SiGe, including related technologies, advanced diagnostics or the role of crystal defects, which are the working fields of many laboratories all over the world. This was also shown by the presentations at the symposium and can be found in the contributions contained in this issue.The organizers would like to thank the participants for their high level contributions and discussions during the symposium. This intensive and open communication allowed the participants to create synergies between the different fields of silicon research and also to build up relationships for cooperation between Chinese and German research groups.Finally, we would like to thank the Sino-German Science Center for the financial support of the symposium.

  9. Infant Mortality and Social Policy. Working Paper No. 203.

    Science.gov (United States)

    Arnold, Carolyne W.

    Less than 2 years after the Omnibus Budget Reconciliation Act (OBRA) of 1981 mandated the reorganization of long-established maternal and child health services and substantially reduced funding of programs, a rise in the incidence of unfavorable maternal and child outcomes was detected in national health data. Data suggest at least an inferential…

  10. 24 CFR 203.49 - Eligibility of adjustable rate mortgages.

    Science.gov (United States)

    2010-04-01

    ... National Housing Act. (a) Types of mortgages insurable. The types of adjustable rate mortgages that are... payment, except that, for these types of mortgages, the first adjustment shall be no sooner or later than... secured by a principal dwelling under the Truth in Lending Act, 15 U.S.C. 1601 et seq. (h)...

  11. 27 CFR 9.203 - Saddle Rock-Malibu.

    Science.gov (United States)

    2010-04-01

    ... Conejo land grant, section 3, T1S/R19W; then (3) Proceed straight east-southeast along the El Conejo land... mile along the El Conejo land grant boundary line to its second intersection with the...

  12. 21 CFR 203.37 - Investigation and notification requirements.

    Science.gov (United States)

    2010-04-01

    ... notification requirements. (a) Investigation of falsification of drug sample records. A manufacturer or authorized distributor of record that has reason to believe that any person has falsified drug sample requests, receipts, or records, or is diverting drug samples, shall: (1) Notify FDA, by telephone or...

  13. 24 CFR 203.333 - Reinstatement of defaulted mortgage.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Reinstatement of defaulted mortgage... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Default Under Mortgage §...

  14. 48 CFR 28.203-7 - Exclusion of individual sureties.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Exclusion of individual... Exclusion of individual sureties. (a) An individual may be excluded from acting as a surety on bonds... of protecting the Government. (b) An individual may be excluded for any of the following causes:...

  15. 48 CFR 28.203-3 - Acceptance of real property.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acceptance of real... Acceptance of real property. (a) Whenever a bond with a security interest in real property is submitted, the..., () performance bond, () or payment bond obligations as an individual surety on solicitation/contract...

  16. Dicty_cDB: VHI203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available s producing significant alignments: (bits) Value AF325215_2( AF325215 |pid:none) Lymphocytic choriomeningitis...5090 |pid:none) Schistosoma japonicum SJCHGC03255 ... 36 2.8 EU480452_2( EU480452 |pid:none) Lymphocytic choriomeningitis...325214_2( AF325214 |pid:none) Lymphocytic choriomeningitis virus... 35 8.2 BX2941

  17. Conventional superconductivity at 203 K at high pressures

    OpenAIRE

    Drozdov, A. P.; Eremets, M. I.; Troyan, I. A.; Ksenofontov, V.; Shylin, S. I.

    2015-01-01

    A superconductor is a material that can conduct electricity with no resistance below its critical temperature (Tc). The highest Tc that has been achieved in cuprates1 is 133 K at ambient pressure2 and 164 K at high pressures3. As the nature of superconductivity in these materials has still not been explained, the prospects for a higher Tc are not clear. In contrast, the Bardeen-Cooper-Schrieffer (BCS) theory gives a guide for achieving high Tc and does not put bounds on Tc, all that is needed...

  18. 38 CFR 20.3 - Rule 3. Definitions.

    Science.gov (United States)

    2010-07-01

    .... (h) Electronic hearing means a hearing on appeal in which an appellant or a representative participates, through voice transmission or through picture and voice transmission, by electronic or other... agency of original jurisdiction being appealed. (j) Law student means an individual pursuing a...

  19. 19 CFR 201.203 - Delegation of authority.

    Science.gov (United States)

    2010-04-01

    ... Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Debt... consumer reporting agencies certain data pertaining to delinquent debts; (d) Use offset procedures to... accordance with the policies contained herein and as otherwise provided by law....

  20. Preface: phys. stat. sol. (a) 203/12

    Science.gov (United States)

    Jackman, Richard B.; Nesládek, Milo; Haenen, Ken

    2006-09-01

    The 30 papers gathered in this issue of physica status solidi (a) give a thorough overview over different topics that were presented during the 11th edition of the International Workshop on Surface and Bulk Defects in CVD Diamond Films (SBDD), which took place from 22 to 24 February 2006, at the Hasselt University in Diepenbeek-Hasselt, Belgium. Since its start more than 10 years ago, the SBDD Workshop has grown into a well-established, yearly early bird meeting place, addressing new emerging science related to the progress in the CVD diamond field. The 10 invited lectures, 29 contributed oral presentations and 26 posters were presented in several sessions during an intense two and a half day long meeting.The number of participants reached 115 this year with participants coming from fifteen countries: Austria, Belgium, Czech Republic, France, Germany, Israel, Italy, Japan, Mexico, Poland, Russia, Singapore, Slovak Republic, Sweden, UK, and USA. The mixture of young and established scientists, including a great proportion of students, made this meeting a hot spot of lively discussions on a wide range of scientific subjects, not only during the meeting itself, but also at several occasions throughout many social events offered by the hospitality of the city of Hasselt.It stands for itself that the workshop would not have been possible without the support of many people and institutions. For financial aid we are especially indebted to the Scientific Research Community Surface Modification of Materials of the F.W.O.-Vlaanderen (Belgium), whose incessant support plays an important role in keeping this meeting going. We also thank the Hasselt University for offering the lecture hall and infrastructure facilities and Seki Technotron Corp. for sponsoring the poster reception and their presence with a table top exhibit. Finally we highly appreciate the active approach of the editorial staff of physica status solidi in this conference and would like to thank most notably Stefan Hildebrandt, Ron Schulz-Rheinländer, Christoph Lellig, and Julia Hübner, for their excellent and patient work, bringing the number of successfully published proceedings of SBDD in pss (a) up to 8 already!To finish, we would all like to invite you to the 12th edition of the SBDD series, newly renamed as Hasselt Diamond Workshop, to be held at its established location of Diepenbeek-Hasselt. We look forward meeting you again at SBDD XII in 2007:Hasselt Diamond Workshop - SBDD XII28 February-2 March 2007Hasselt University, Diepenbeek-Hasselt, Belgiumhttp://www.imo.uhasselt.be/SBDD2007London, Paris, Hasselt, August 2006

  1. Dicty_cDB: CFC203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available a ... 40 0.17 EF084406_1( EF084406 |pid:none) Picea sitchensis clone WS02712_K12... 39 0.38 ( P56873 ) RecName: Full=Sjoe... days embryo whole ... 37 1.4 ( O60232 ) RecName: Full=Sjoegren syndrome/scleroderma autoantigen... 36 1.9 B

  2. 12 CFR 303.203 - Applications for capital distributions.

    Science.gov (United States)

    2010-01-01

    ... requires an application under section 18(i) of the FDI Act (12 U.S.C. 1828(i)) as implemented by § 303.241... with, or made a part of, the application filed pursuant to section 38 of the FDI Act (12 U.S.C. 1831o)....

  3. 5 CFR 734.203 - Participation in nonpartisan activities.

    Science.gov (United States)

    2010-01-01

    ..., e.g., the Federal Property Management Regulations in 41 CFR chapter 101. Example 2: An employee... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Participation in nonpartisan activities... Participation in nonpartisan activities. An employee may: (a) Express his or her opinion privately and...

  4. 47 CFR 80.203 - Authorization of transmitters for licensing.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Authorization of transmitters for licensing. 80... transmitters for licensing. (a) Each transmitter authorized in a station in the maritime services after... this chapter. Transmitters of a model authorized before October 1, 1986 will be considered...

  5. 18 CFR 281.203 - Definitions and cross references.

    Science.gov (United States)

    2010-04-01

    ... in 7 CFR part 2900, et seq. (3) Essential agricultural user means a person who uses natural gas for... such as space heating, air conditioning, hot water heating, cooking, clothes drying, and other residential uses and includes apartment buildings and other multi-unit buildings. (9) Small...

  6. 40 CFR 240.203-2 - Recommended procedures: Design.

    Science.gov (United States)

    2010-07-01

    ..., easy to maintain, and consistent with the land use of the area. (d) Employee convenience facilities and... operating unit malfunctions. (j) Sampling capability should be designed into the facility so that each process stream can be sampled, and the utilities required to do so should be close at hand. The...

  7. 29 CFR 541.203 - Administrative exemption examples.

    Science.gov (United States)

    2010-07-01

    ... customer's needs and financial circumstances; advising the customer regarding the advantages and... administrative exemption. (c) An employee who leads a team of other employees assigned to complete major projects... the employee does not have direct supervisory responsibility over the other employees on the team....

  8. 24 CFR 203.357 - Deed in lieu of foreclosure.

    Science.gov (United States)

    2010-04-01

    ... deed in lieu of foreclosure from a corporate mortgagor in compliance with the requirements of paragraph... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... foreclosure, the mortgagee may acquire property from one other than a corporate mortgagor by...

  9. 48 CFR 15.203 - Requests for proposals.

    Science.gov (United States)

    2010-10-01

    ... information regarding cost comparisons between Government and contractor performance. (c) Electronic commerce... RFP shall specify the electronic commerce method(s) that offerors may use (see subpart 4.5). (d... and suitability of electronic commerce methods; and (iv) Adequacy of administrative procedures...

  10. 12 CFR Supplement I to Part 203 - Staff Commentary

    Science.gov (United States)

    2010-01-01

    ... to compute a debt-to-income ratio but also relies on the applicant's annual bonus to evaluate... calculates an annual percentage rate, consistent with Regulation Z (see 12 CFR 226.22 and part 226, appendix... Affairs of the Federal Reserve Board issues formal staff interpretations of Regulation C (12 CFR part...

  11. Preparation and characterization of Cr203 system optically variable pigment

    Institute of Scientific and Technical Information of China (English)

    DU Haiyan; ZHANG Hua; CHEN Qirong; SUN Jiayue; XU Wencai; MA Erjun

    2007-01-01

    An optically variable pigment was produced by wet chemical method, where TiO2-coated mica with interfer-ence colors acted as the substrate materials. The structure of the pigment was characterized by X-ray diffraction (XRD),and its optically variable effect was investigated by X-Rite MA86 Ⅱ five angles spectrophotometer. The impact of differ-ent interference substrate materials for improving the color travel effect was studied, and the influence of white and black background on the hue and the color travel effect were stud-ied. Results showed that optically variable pigments can be prepared by coating Cr2O3 on the surface of the pretreated TiO2-coated mica. The color travel effect was sensitive to the change of substrate materials, and different backgrounds can influence the hue and the color travel effect of the pigment.

  12. 48 CFR 36.203 - Government estimate of construction costs.

    Science.gov (United States)

    2010-10-01

    ... simplified acquisition threshold. The contracting officer may require an estimate when the cost of required... the associated cost breakdown figures in the Government estimate, but only to the extent deemed... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Government estimate...

  13. 15 CFR 971.203 - Commercial recovery plan.

    Science.gov (United States)

    2010-01-01

    ... ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR COMMERCIAL RECOVERY PERMITS Applications Contents... requirements for resource assessment and logical mining unit (§ 971.501); (6) A description of the methods...

  14. Editorial: phys. stat. sol. (a) 203/1

    Science.gov (United States)

    Stutzmann, Martin

    2006-01-01

    Dear Colleagues and Friends,on behalf of the Publishers, the Editorial Office, and the Editors of physica status solidi we wish you all the best for the coming year 2006! It is our sincere hope that your personal and professional experience with our journal has been a positive one and that you will continue to choose physica status solidi for the publication of your scientific findings in solid state physics also in the future.In doing so, you will be in increasingly good company! As a matter of fact, 2005 has been a year of exceptional growth in the number of manuscripts submitted to physica status solidi. Thus, the number of Original Papers which have reached our Editorial Office in Berlin has increased by as much as 30% compared to the long term average over the last ten years. For the Rapid Research Letter section, the corresponding increase has been even more impressive: more than +100% just in the last two years. We view this development as a confirmation of our longstanding efforts to ensure a timely publication service of high scientific quality. One relevant indicator for the high scientific standards expected from articles which are submitted for publication in physica status solidi is the average acceptance rate, which currently is less than 40%. This rate has continuously decreased from a value of about 60% ten years ago and bears witness to our efforts to strive for quality rather than quantity.Also, physica status solidi has been able to continue its long tradition as a truly international journal, despite of the strong competition in an established field such as solid state physics. In 2005, submitted papers have originated almost equally from the Americas, Europe, and Asia, with a clearly growing contribution from China, India, and Japan. We are actively working together with our international Editorial Boards and the Regional Editors to maintain a reasonable balance among papers from different parts of the world. The increasing international visibility of physica status solidi is impressively documented by the ever rising numbers of article downloads via the internet: on the average, each of the 2000 articles published annually in physica status solidi is presently accessed about 100 times via the www.Finally, let me mention some other recent developments, which are not so directly visible from the outside. Thus, a new all electronic publishing system has become operative in our Berlin Editorial Office in 2005, which allows a more efficient and timely handling of manuscripts from submission to publication (www.manuscriptXpress.com) and is particularly valuable for the editing of conference proceedings (conferences.wiley-vch.de). In addition, the functionality of the journal within the Wiley InterScience website has been enhanced by new features such as Citation Tracking. Together with the ongoing digitization of all physica status solidi issues since the 1960s, which is expected to be complete in 2006, this makes the physica status solidi homepage at Wiley InterScience a very valuable tool for literature search in solid state physics, past and present. Try it out at www.interscience.wiley.com!All of us from physica status solidi would like to convey to you our very best wishes for good health and success in the coming year 2006!

  15. Dicty_cDB: CHQ203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ete sequence. 100 7e-17 1 DT364098 |DT364098.1 JGI_ANNN9278.rev ANNN Pimephales promelas Whole (L) Pimephales promelas... cDNA clone ANNN9278 3', mRNA sequence. 48 0.22 1 DT347978 |DT347978.1 JGI_CAAX10802.fwd CAAX Pimephales promelas... testis 7-8 month adults, males and females pooled (L) Pimephales promelas... cDNA clone CAAX10802 5', mRNA sequence. 48 0.22 1 DT309975 |DT309975.1 JGI_CAAX1517.fwd CAAX Pimephales promelas... testis 7-8 month adults, males and females pooled (L) Pimephales promelas cDNA clone CAAX1517

  16. Dicty_cDB: SHC203 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available A sequence. 56 0.001 1 CV682907 |CV682907.1 service43_H06_sjs2-16-2B11-T3 SJS Schistosoma japonicum cDNA, mR...NA sequence. 56 0.001 1 CV682854 |CV682854.1 service30_G09_sjs2-14-10C09-T3 SJS Schistosoma japonicum cDNA,

  17. 5 CFR 410.203 - Options for developing employees.

    Science.gov (United States)

    2010-01-01

    ...-development activities, coaching, mentoring, career development counseling, details, rotational assignments... of options to meet their mission-related organizational and employee development needs, such...

  18. 32 CFR 2004.23 - Cost Reports [203(d)].

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Cost Reports . 2004.23 Section 2004.23 National Defense Other Regulations Relating to National Defense INFORMATION SECURITY OVERSIGHT OFFICE, NATIONAL ARCHIVES AND RECORDS ADMINISTRATION NATIONAL INDUSTRIAL SECURITY PROGRAM DIRECTIVE NO. 1 Operations §...

  19. 24 CFR 984.203 - FSS family selection procedures.

    Science.gov (United States)

    2010-04-01

    ... Action Plan. (c) Motivation as a selection factor—(1) General. a PHA may screen families for interest, and motivation to participate in the FSS program, provided that the factors utilized by the PHA are those which solely measure the family's interest, and motivation to participate in the FSS program....

  20. 14 CFR 1274.203 - Solicitations/cooperative agreement notices.

    Science.gov (United States)

    2010-01-01

    ..., occupational health, security (including information technology security), environmental, export control, and... CAN shall notify potential recipients of the relative importance of factors, and any subfactors or... with its proposal stating “How” the recipient will accomplish the task(s). Depending on its...

  1. 23 CFR 500.203 - TMS general requirements.

    Science.gov (United States)

    2010-04-01

    ... inspection and copying as prescribed in 49 CFR part 7, appendix D. (c) The TMS shall cover all public roads.... Available for inspection as prescribed in 49 CFR part 7, appendix D. 5 Traffic Monitoring Guide, DOT/FHWA, publication No. FHWA-PL-95-031, February 1995. Available for inspection and copying as prescribed in 49...

  2. 49 CFR 571.203 - Standard No. 203; Impact protection for the driver from the steering control system.

    Science.gov (United States)

    2010-10-01

    ... protection for the driver from the steering control system. S1. Purpose and scope. This standard specifies... a result of impact. S2. Application. This standard applies to passenger cars and to multipurpose... does not apply to vehicles that conform to the frontal barrier crash requirements (S5.1) of Standard...

  3. 30 CFR 203.78 - Do I keep relief approved by MMS under §§ 203.60-203.77 for my lease, unit or project if prices...

    Science.gov (United States)

    2010-07-01

    ... base oil price threshold set under paragraph (a) is $28.00 per barrel, and the daily closing NYMEX light sweet crude oil prices for the previous calendar year exceeds $28.00 per barrel, as adjusted in... daily closing NYMEX light sweet crude oil prices for the previous calendar year exceeds $3.50...

  4. Protein (Viridiplantae): 350536073 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available ilization-independent endosperm protein Solanum lycopersicum MAARVPLGCEPVVGSLTPSRKK...024:1740 3398:1740 71240:1315 91827:1315 71274:203 91888:203 4069:203 4070:203 424551:203 424574:203 4107:203 49274:203 4081:203 fert

  5. X-ray absorption spectroscopic analyses and fluorescence emission characteristics of PbO-Bi203-Ga203 glasses doped with rare-earth ions

    Science.gov (United States)

    Choi, Yong Gyu; Kim, Kyong-Hon; Chernov, Vladimir A.; Heo, Jong

    1999-12-01

    A representative of heavy metal oxide glasses, i.e., a PbO- Bi2O3-Ga2O3 glass, was investigated to identify the network structure of the glass and the electronic transition properties of rare-earth ions doped. X-ray absorption spectroscopic analyses showed that gallium forms GaO4 tetrahedral units with an average Ga-O bond length of approximately 1.87 A. Lead forms both PbO3 and PbO4 polyhedra, but the fraction of PbO4 decreases with decreasing PbO content. Bismuth in glasses constructs BiO5 and BiO6 polyhedra, which have a similar coordination scheme of the (alpha) -Bi2O3 crystal. Formation of three-coordinated oxygens is necessary to compensate shortage of oxygens to be two-fold coordinated. These glasses exhibit a relatively good thermal stability as well as the lowest phonon energy among oxide glasses, and thereby enhance numerous fluorescence emissions that are quenched in the conventional oxide glasses. Magnitudes of multiphonon relaxation are the lowest among oxide glasses and comparable to those of fluoride glasses. Fluorescence emission characteristics of Pr3+: 1.3 micrometer and Er3+: 2.7 micrometer were discussed in detail. In addition, influence of OH- on the Nd3+: 1.3 micrometer emission was analyzed. Further research efforts on impurity minimization and fiberization may realize a new oxide-based fiber-optic host.

  6. Compound list: simvastatin [Open TG-GATEs

    Lifescience Database Archive (English)

    Full Text Available simvastatin SST 00117 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/simv...astatin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/simv...astatin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/simv...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/simvastatin.Rat.in_vivo.Liver.Repeat.zip ...

  7. 7 CFR 205.203 - Soil fertility and crop nutrient management practice standard.

    Science.gov (United States)

    2010-01-01

    ...) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling... materials. (c) The producer must manage plant and animal materials to maintain or improve soil...

  8. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (203c-0613-332211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  9. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (203a-0613-272217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  10. Yeast Interacting Proteins Database: YJR091C, YDR203W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available based on available experimental and comparative sequence data Rows with this prey as prey (1) Rows with this...available experimental and comparative sequence data Rows with this prey as prey Rows with this prey as prey

  11. Aqueous chemical growth of alpha-Fe2O3-alpha-Cr203 nanocompositethin films

    Energy Technology Data Exchange (ETDEWEB)

    Vayssieres, Lionel; Guo, Jinghua; Nordgren, Joseph

    2001-06-30

    We are reporting here on the inexpensive fabrication and optical properties of an iron(III) oxide chromium(III) oxide nanocomposite thin film of corundum crystal structure. Its novel and unique-designed architecture consists of uniformed, well-defined and oriented nanorods of Hematite (alpha-Fe2O3) of 50 nm in diameter and 500nm in length and homogeneously distributed nonaggregated monodisperse spherical nanoparticles of Eskolaite (alpha-Cr2O3) of 250 nm in diameter. This alpha-Fe2O3 alpha-Cr2O3 nanocomposite thin film is obtained by growing, directly onto transparent polycrystalline conducting substrate, an oriented layer of hematite nanorods and growing subsequently, the eskolaite layer. The synthesis is carried out by a template-free, low-temperature, multilayer thin film coating process using aqueous solution of metal salts as precursors. Almost 100 percent of the light is absorbed by the composite film between 300 and 525 nm and 40 percent at 800 nm which yields great expectations as photoanode materials for photovoltaic cells and photocatalytic devices.

  12. 76 FR 24957 - Nineteenth Meeting: RTCA Special Committee 203: Unmanned Aircraft Systems

    Science.gov (United States)

    2011-05-03

    ... Spectrum Paper Update Continuity Paper Update Availability Paper Updates Sense and Avoid Workgroup... Back Briefs Other Business Date, Place, and Time for next Plenary Adjourn Attendance is open to the...) Update Work Plan Status Work Group Update Overview of Product Team Breakout Session Closing...

  13. People and things. CERN Courier, May 1980, v. 20(3)

    International Nuclear Information System (INIS)

    The article reports on achievements of various people, staff changes and position opportunities within the CERN organization and contains news updates on upcoming or past events, for example the SLAC Summer Institute on Particle Physics. In other news another step in the progress towards higher intensity, better quality beams from the CERN SPS has been taken with the recent introduction of a 'Landau damping cavity' in the ring. A limited edition of 'Aesthetics and Science', a burgundy leather-bound volume containing the proceedings of the International Symposium in honour of Robert R. Wilson, held at Fermilab on 27 April 1979, has recently been published. The contract for the refrigeration system for the ISABELLE 400 GeV proton-proton storage rings at Brookhaven was awarded in March to Helix Technology Corp. for a sum of 6.5 million dollars

  14. 41 CFR 105-54.203-3 - Submission to Library of Congress.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Submission to Library of... Submission to Library of Congress. The GSA Committee Management Officer furnishes a copy of each charter to the Library of Congress when or shortly after copies are filed with the requisite committees of...

  15. 21 CFR 203.39 - Donation of drug samples to charitable institutions.

    Science.gov (United States)

    2010-04-01

    ... charitable institution, or personal delivery by a licensed practitioner or an agent or employee of the..., brand name, quantity, and lot or control number of the drug sample donated; and (3) The date of...

  16. 34 CFR 403.203 - What are the State's responsibilities for a State assessment?

    Science.gov (United States)

    2010-07-01

    ... the groups described in 34 CFR 400.6(c); and (2) Use information gathered by the National Occupational... respect to vocational education. (7) Raising the quality of vocational education programs in schools with... workplace and to the occupations for which students are to be trained, and the extent to which...

  17. 24 CFR 203.43e - Eligibility of mortgages covering houses in federally impacted areas.

    Science.gov (United States)

    2010-04-01

    ..., rehabilitation or purchase of property located near any installation of the Armed Forces of the United States in... probable cost to the Government; and (2) The Secretary of Defense certifies that there is no intention...

  18. Rilem TC 203-RHM: Repair mortars for historic masonry. Requirements for repointing mortars for historic masonry

    NARCIS (Netherlands)

    Hees, R.P.J. van; Groot, C.; Hughes, J.J.; Balen, K. van; Bicer-Simsir, B.; Binda, L.; Elsen, J.; Konow, T. von; Lindqvist, J.E.; Papayanni, I.; Subercaseaux, M.; Tedeschi, C.; Toumbakari, E.E.; Thompson, B.

    2012-01-01

    This paper gives a summary of functional and performance requirements for repointing mortars for historic masonry (design, execution and maintenance). Successful performance of repair and conservation of mortar in historic masonry requires more care with design and execution than with modern masonry

  19. Rilem TC 203-RHM: repair mortars for historic masonry. Performance requirements for renders and plasters

    NARCIS (Netherlands)

    Hees, R.P.J. van; Hughes, J.J.; Balen, K. van; Bicer-Simsir, B.; Binda, L.; Elsen, J.; Konow, T. von; Lindqvist, J.E.; Maurenbrecher, P.; Papayanni, I.; Subercaseaux, M.; Tedeschi, C.; Toumbakari, E.E.; Thompson, M.

    2012-01-01

    This article focuses on repair or replacement mortars for historical buildings. Both the decision process and questions arising are dealt with, in order to better define and illustrate technical requirements for mortars to be used for the repair or restoration of monuments and historic buildings (ma

  20. 7 CFR 59.203 - Mandatory daily reporting for sows and boars.

    Science.gov (United States)

    2010-01-01

    ... AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT... packer of sows and boars shall report to the Secretary for each business day of the packer not later than... priced, excluding inferior swine, during the prior business day of the packer all purchase data,...

  1. CPI’s Aluminum Output Reached 2.03 Million Tons in 2011

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    <正>In an interview,Lu Qizhou,general manager of China Power Investment Corp.(CPI),noted that from 2008 on power generation companies have been operating at a loss. Against such background,it is more difficult for a power generation company to go public as a whole.In

  2. 21 CFR 203.38 - Sample lot or control numbers; labeling of sample units.

    Science.gov (United States)

    2010-04-01

    ... unit label. The manufacturer or authorized distributor of record of a drug sample shall include on the.... (b) Records containing lot or control numbers required for all drug samples distributed. A manufacturer or authorized distributor of record shall maintain for all samples distributed records of...

  3. 24 CFR 203.260 - Amount of mortgage insurance premium (periodic MIP).

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Amount of mortgage insurance... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and...

  4. 24 CFR 203.421 - Allocation of Mutual Mortgage Insurance Fund income or loss.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Allocation of Mutual Mortgage... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations...

  5. 24 CFR 203.432 - Effect of sale of insured mortgage.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Effect of sale of insured mortgage... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Sale, Assignment and Pledge...

  6. 24 CFR 203.431 - Sale of insured mortgage to approved mortgagee.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Sale of insured mortgage to... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations...

  7. 24 CFR 203.437 - Mortgages involving a dwelling unit in a cooperative housing development.

    Science.gov (United States)

    2010-04-01

    ...-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights... right of permanent possession of the dwelling unit. (e) In lieu of the types of title evidence...

  8. Tank 241-BY-109, cores 201 and 203, analytical results for the final report

    Energy Technology Data Exchange (ETDEWEB)

    Esch, R.A.

    1997-11-20

    This document is the final laboratory report for tank 241-BY-109 push mode core segments collected between June 6, 1997 and June 17, 1997. The segments were subsampled and analyzed in accordance with the Tank Push Mode Core Sampling and Analysis Plan (Bell, 1997), the Tank Safety Screening Data Quality Objective (Dukelow, et al, 1995). The analytical results are included.

  9. 30 CFR 203.89 - What is in a cost report?

    Science.gov (United States)

    2010-07-01

    ... based on historical costs, engineering estimates, or analogous projects. These costs cover: (1... evaluations). (d) Transportation costs, based on historical costs, engineering estimates, or analogous... lines; and (3) Gas plant processing for natural gas liquids. (e) Abandonment costs, based on...

  10. 48 CFR 1837.203-70 - Providing contractors access to sensitive information.

    Science.gov (United States)

    2010-10-01

    ... submit with its proposal a preliminary analysis of possible organizational conflicts of interest that... the NASA organizational element or activity that requires specified services to be provided. (3) As... organizational conflicts of interest avoidance plan. (d) This comprehensive plan shall incorporate any...

  11. CALiPER Report 20.3: Robustness of LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    Poplawski, Michael E.; Royer, Michael P.; Brown, Charles C.

    2014-12-31

    Three samples of 40 of the Series 20 PAR38 lamps underwent multi-stress testing, whereby samples were subjected to increasing levels of simultaneous thermal, humidity, electrical, and vibrational stress. The results do not explicitly predict expected lifetime or reliability, but they can be compared with one another, as well as with benchmark conventional products, to assess the relative robustness of the product designs. On average, the 32 LED lamp models tested were substantially more robust than the conventional benchmark lamps. As with other performance attributes, however, there was great variability in the robustness and design maturity of the LED lamps. Several LED lamp samples failed within the first one or two levels of the ten-level stress plan, while all three samples of some lamp models completed all ten levels. One potential area of improvement is design maturity, given that more than 25% of the lamp models demonstrated a difference in failure level for the three samples that was greater than or equal to the maximum for the benchmarks. At the same time, the fact that nearly 75% of the lamp models exhibited better design maturity than the benchmarks is noteworthy, given the relative stage of development for the technology.

  12. 21 CFR 203.30 - Sample distribution by mail or common carrier.

    Science.gov (United States)

    2010-04-01

    ... pharmacy of a hospital or other health care entity, by mail or common carrier, provided that: (1) The... to the pharmacy of a hospital or other health care entity is required to contain, in addition to all... the pharmacy of a hospital or other health care entity at the request of a licensed practitioner,...

  13. Hyperspectral Imagery for the Main Eight Hawaiian Islands:Oahu (203c-0613-272217)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project is a cooperative effort among the National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment; the...

  14. 76 FR 63602 - Voting Rights Act Amendments of 2006, Determinations Under Section 203

    Science.gov (United States)

    2011-10-13

    .... California: State Coverage Hispanic. Alameda County Asian (Chinese). Alameda County Asian (Filipino). Alameda County Hispanic. Alameda County Asian (Vietnamese). Colusa County Hispanic. Contra Costa County Hispanic... Hispanic. Lehigh County Hispanic. Philadelphia County Hispanic. Rhode Island: Central Falls city...

  15. Preparation of Carbon Nanotubes by the Catalysis of Polymer Metal Complex on Porous Al203 Matrix

    Institute of Scientific and Technical Information of China (English)

    SHI; YanLi

    2001-01-01

    At present, synthesis of carbon nanotubes (CNTs) is normally conducted on a vapor-to-solid interface at ca. 500-3500℃ via various vapor phase methods, such as are discharge, laser ablation, catalytic pyrolysis and chemical vapor deposition, etc.1-2 Recently, channel materials (such as channels of alumina and of AlPO4-5 zeolite) 3 have been utilized as solid-state templates to grow CNTs inside the channel. Here we described a novel method to prepare the carbon nanotubes based on the decomposition of C2H2 gas on the Co-Ni catalyst anchored by polymer complex on the porous A12O3 matrix. The degree of graphitization of synthesized CNTs and catalysts are of great interest.  ……

  16. Preparation of Carbon Nanotubes by the Catalysis of Polymer Metal Complex on Porous Al203 Matrix

    Institute of Scientific and Technical Information of China (English)

    SHI YanLi; ZHANG XiaoGang; LI HuLin

    2001-01-01

    @@ At present, synthesis of carbon nanotubes (CNTs) is normally conducted on a vapor-to-solid interface at ca. 500-3500℃ via various vapor phase methods, such as are discharge, laser ablation, catalytic pyrolysis and chemical vapor deposition, etc.1-2 Recently, channel materials (such as channels of alumina and of AlPO4-5 zeolite) 3 have been utilized as solid-state templates to grow CNTs inside the channel. Here we described a novel method to prepare the carbon nanotubes based on the decomposition of C2H2 gas on the Co-Ni catalyst anchored by polymer complex on the porous A12O3 matrix. The degree of graphitization of synthesized CNTs and catalysts are of great interest.

  17. 9 CFR 203.7 - Statement with respect to meat packer sales and purchase contracts.

    Science.gov (United States)

    2010-01-01

    ... concerning condition, grade, weight, or shipping instructions. (b) It is believed that both seller and buyer... of the contract. (2) Quality and condition. (i) A seller has the responsibility of making certain... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Statement with respect to meat...

  18. CALiPER Report 20.3: Robustness of LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    Poplawski, Michael E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Royer, Michael P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Brown, Charles C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-12-01

    Three samples of 40 of the Series 20 PAR38 lamps underwent multi-stress testing, whereby samples were subjected to increasing levels of simultaneous thermal, humidity, electrical, and vibrational stress. The results do not explicitly predict expected lifetime or reliability, but they can be compared with one another, as well as with benchmark conventional products, to assess the relative robustness of the product designs. On average, the 32 LED lamp models tested were substantially more robust than the conventional benchmark lamps. As with other performance attributes, however, there was great variability in the robustness and design maturity of the LED lamps. Several LED lamp samples failed within the first one or two levels of the ten-level stress plan, while all three samples of some lamp models completed all ten levels. One potential area of improvement is design maturity, given that more than 25% of the lamp models demonstrated a difference in failure level for the three samples that was greater than or equal to the maximum for the benchmarks. At the same time, the fact that nearly 75% of the lamp models exhibited better design maturity than the benchmarks is noteworthy, given the relative stage of development for the technology.

  19. Yeast Interacting Proteins Database: YPL203W, YIL033C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available tein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metab...ependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metab

  20. 29 CFR 2530.203-3 - Suspension of pension benefits upon employment.

    Science.gov (United States)

    2010-07-01

    ... particular job classification, job description or industrial occupation constitutes or is included in a trade... withholds payments that his benefits are suspended. Such notification shall contain a description of the specific reasons why benefit payments are being suspended, a general description of the plan...

  1. 7 CFR 22.203 - Major responsibilities under title VI, Sec. 603.

    Science.gov (United States)

    2010-01-01

    ... sewage and solid waste management, and rural industrialization. (3) The Rural Development Service will..., Chairman of the Urban Development Committee; the Secretary of Transportation, Chairman of...

  2. Synthesis and characterization of InP and Ga203 nanowires

    Science.gov (United States)

    Han, Zhanghua; Wang, Fei; Forsberg, Erik; Cao, Xia

    2005-01-01

    We report on the synthesis and characterization of crystalline InP and Ga2O3 nanowires. The nanowires are synthesized using a simple method based on vapor-liquid-solid (VLS) growth; a method we believe could form the basis of cheap and simple fabrication of crystalline nanowires of a broad range of semiconductor materials, including III-V compounds and semiconductor oxides. The reported InP nanowires have an average diameter of 30nm and the Ga2O3 nanowires diameters down to 100nm. Characterization data including SEM, XRD, TEM and PL are presented.

  3. 24 CFR 203.10 - Informed consumer choice for prospective FHA mortgagors.

    Science.gov (United States)

    2010-04-01

    ... Street, SW, Washington, DC 20410-8000; telephone (202) 708-2700 (this is not a toll-free number), or the... (800) 440-8647; or Santa Ana, CA (888) 827-5605). Hearing- or speech-impaired individuals may access these numbers via TTY by calling the toll-free Federal Information Relay Service at (800) 877-8339....

  4. 31 CFR 540.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    .... person holding funds, such as currency, bank deposits, or liquidated financial obligations subject to... account: (i) In a federally-insured U.S. bank, thrift institution, or credit union, provided the funds are... holder of blocked tangible property, such as chattels or real estate, or of other blocked property,...

  5. 31 CFR 594.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... currency, bank deposits, or liquidated financial obligations, subject to § 594.201(a) shall hold or place...-insured U.S. bank, thrift institution, or credit union, provided the funds are earning interest at rates... tangible property, such as chattels or real estate, or of other blocked property, such as debt or...

  6. 31 CFR 544.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... funds, such as currency, bank deposits, or liquidated financial obligations, subject to § 544.201(a...) In a federally-insured U.S. bank, thrift institution, or credit union, provided the funds are earning... affirmative obligation for the holder of blocked tangible property, such as chattels or real estate, or...

  7. 31 CFR 588.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... currency, bank deposits, or liquidated financial obligations subject to § 588.201(a) shall hold or place...-insured U.S. bank, thrift institution, or credit union, provided the funds are earning interest at rates... holder of blocked tangible property, such as chattels or real estate, or of other blocked property,...

  8. 31 CFR 545.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... currency, bank deposits, or liquidated financial obligations, subject to § 545.201(a) shall hold or place...-insured U.S. bank, thrift institution, or credit union, provided the funds are earning interest at rates... tangible property, such as chattels or real estate, or of other blocked property, such as debt or...

  9. 31 CFR 541.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... directed by the Office of Foreign Assets Control, any U.S. person holding funds, such as currency, bank... term blocked interest-bearing account means a blocked account: (i) In a federally-insured U.S. bank... tangible property, such as chattels or real estate, or of other blocked property, such as debt or...

  10. 31 CFR 542.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... directed by the Office of Foreign Assets Control, any U.S. person holding funds, such as currency, bank... term blocked interest-bearing account means a blocked account: (i) In a federally-insured U.S. bank... tangible property, such as chattels or real estate, or of other blocked property, such as debt or...

  11. 31 CFR 586.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... U.S. person holding funds, such as currency, bank deposits, or liquidated financial obligations... blocked account: (i) In a federally-insured U.S. bank, thrift institution, or credit union, provided the... affirmative obligation for the holder of blocked tangible property, such as chattels or real estate, or...

  12. 31 CFR 543.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... currency, bank deposits, or liquidated financial obligations, subject to § 543.201(a) shall hold or place...-insured U.S. bank, thrift institution, or credit union, provided the funds are earning interest at rates... holder of blocked tangible property, such as chattels or real estate, or of other blocked property,...

  13. 31 CFR 547.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ..., such as currency, bank deposits, or liquidated financial obligations, subject to § 547.201(a) shall... federally-insured U.S. bank, thrift institution, or credit union, provided the funds are earning interest at... affirmative obligation for the holder of blocked tangible property, such as chattels or real estate, or...

  14. 31 CFR 546.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... directed by the Office of Foreign Assets Control, any U.S. person holding funds, such as currency, bank... term blocked interest-bearing account means a blocked account: (i) In a federally-insured U.S. bank... tangible property, such as chattels or real estate, or of other blocked property, such as debt or...

  15. 31 CFR 548.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... directed by the Office of Foreign Assets Control, any U.S. person holding funds, such as currency, bank... term blocked interest-bearing account means a blocked account: (i) In a federally-insured U.S. bank... tangible property, such as chattels or real estate, or of other blocked property, such as debt or...

  16. 31 CFR 587.203 - Holding of funds in interest-bearing accounts; investment and reinvestment.

    Science.gov (United States)

    2010-07-01

    ... Control, any U.S. person holding funds, such as currency, bank deposits, or liquidated financial... account means a blocked account: (i) In a federally-insured U.S. bank, thrift institution, or credit union... affirmative obligation for the holder of blocked tangible property, such as chattels or real estate, or...

  17. Assessment of mercury emission at Norcem's cement kiln by use of 203 Hg tracer

    OpenAIRE

    Eriksen, Dag Øistein; Tokheim, Lars-André; Eriksen, T.A.; Meyer, Julien; Qvenild, Carsten

    2005-01-01

    In manufacture of cement clinker, mercury is introduced in the cement kiln system via the fuels and as constituents in the raw materials, i.e., limestone, iron ore, etc. The permissible emission of Hg to air is very low (0.05 mg/Nm3) due to its toxicity. Thus, it is important to know how mercury distributes and behaves in the kiln system. The objective of the study was to measure the distribution of mercury in the kiln system, to measure the hold up time of Hg, to measure the portion...

  18. 30 CFR 203.48 - Do I keep royalty relief if prices rise significantly?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Do I keep royalty relief if prices rise... royalty relief if prices rise significantly? (a) You must pay royalties on all gas and oil production for... when the average daily closing NYMEX natural gas price exceeds the applicable threshold price shown...

  19. 30 CFR 203.36 - Do I keep royalty relief if prices rise significantly?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Do I keep royalty relief if prices rise... keep royalty relief if prices rise significantly? (a) You must pay royalties on all gas production to... closing New York Mercantile Exchange (NYMEX) natural gas price exceeds the applicable threshold...

  20. Common Criteria Protection Profile "Multiple Independent Levels of Security: Operating System" [V2.03

    OpenAIRE

    Furgel, Igor; Saftig, Viola

    2016-01-01

    This Protection Profile ‘Multiple Independent Levels of Security: Operating System (MILS PP: Operating System)’ is issued by the EURO-MILS Consortium. This PP addresses only Operating System as part of a MILS final integrated system. This PP is intended to be part of a set of MILS PPs that should comprise, in the future, also other PPs regarding MILS architecture, like a PP addressing both underlying Hardware Platform and Operating System together and a PP for the entire integ...