WorldWideScience

Sample records for astatine 200

  1. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production.

  2. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  3. Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Jakobsson, U., E-mail: ulrjak@kth.se; Cederwall, B. [KTH, The Division of Nuclear Physics, AlbaNova University Center, SE-10691 Stockholm (Sweden); Uusitalo, J.; Auranen, K.; Badran, H.; Cox, D. M.; Grahn, T.; Greenlees, P. T.; Julin, R.; Juutinen, S.; Herzáň, A.; Konki, J.; Leino, M.; Mallaburn, M.; Pakarinen, J.; Papadakis, P.; Partanen, J.; Rahkila, P.; Sandzelius, M.; Sarén, J. [University of Jyvaskyla, Department of Physics, P.O. Box 35, FI-40014 University of Jyvaskyla (Finland); and others

    2015-10-15

    Low-lying states in neutron-deficient astatine and francium nuclei have been studied by means of in-beam and delayed spectroscopy. The 13/2{sup +} state has been observed in francium nuclei with a similar down-sloping trend as in neighbouring astatine and bismuth isotopes, as a function of decreasing neutron number. A systematic trend can also now be seen for the 1/2{sup +} state both in astatine and francium nuclei, where the level energy decreases steeply as a function of neutron number when moving further away from the neutron shell closure. This trend is very similar between astatine nuclei and their francium isotones. Moreover, shape coexistence has been observed between the 13/2{sup +} state and the spherical 9/2{sup −} ground state in {sup 203}Fr and {sup 205}Fr.

  4. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom

    2015-01-01

    and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting......To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...

  5. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    NARCIS (Netherlands)

    Rothe, S.; Andreyev, A. N.; Antalic, S.; Borschevsky, A.; Capponi, L.; Cocolios, T. E.; De Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.; Kaldor, U.; Kudryavtsev, Yuri; Koester, U.; Lane, J. F. W.; Lassen, J.; Liberati, V.; Lynch, K. M.; Marsh, B. A.; Nishio, K.; Pauwels, D.; Pershina, V.; Popescu, L.; Procter, T. J.; Radulov, D.; Raeder, S.; Rajabali, M. M.; Rapisarda, E.; Rossel, R. E.; Sandhu, K.; Seliverstov, M. D.; Sjoedin, A. M.; Van den Bergh, P.; Van Duppen, P.; Venhart, M.; Wakabayashi, Y.; Wendt, K. D. A.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviou

  6. Laser photodetachment of radioactive ions: towards the determination of the electronegativity of astatine

    CERN Multimedia

    Rothe, Sebastian; Welander, Jakob Emanuel; Chrysalidis, Katerina; Day Goodacre, Thomas; Fedosseev, Valentine; Fiotakis, Spyridon; Forstner, Oliver; Heinke, Reinhard Matthias; Johnston, Karl; Kron, Tobias; Koester, Ulli; Liu, Yuan; Marsh, Bruce; Ringvall Moberg, Annie; Rossel, Ralf Erik; Seiffert, Christoph; Studer, Dominik; Wendt, Klaus; Hanstorp, Dag

    2017-01-01

    Negatively charged ions are mainly stabilized through the electron correlation effect. A measure of the stability of a negative ion is the electron affinity, which the energy gain by attaching an electron to a neutral atom. This fundamental quantity is, due to the almost general lack of bound excited states, the only atomic property that can be determined with high accuracy for negative ions. We will present the results of the first laser photodetachment studies of radioactive negative ions at CERN-ISOLDE. The photodetachment threshold for the radiogenic iodine isotope 128I was measured successfully, demonstrating the performance of the upgraded GANDALPH experimental beam line. The first detection of photo-detached astatine atoms marks a milestone towards the determination of the EA of this radioactive element.

  7. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron affinity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photo-detachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral line width of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in off-line tests by the clear observation of the photo-detachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148.

  8. Ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and ionic radii of element Uus (Z = 117) and astatine.

    Science.gov (United States)

    Chang, Zhiwei; Li, Jiguang; Dong, Chenzhong

    2010-12-30

    Multiconfiguration Dirac-Fock (MCDF) method was employed to calculate the first five ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and radii for the element Uus and its homologue At. Main valence correlation effects were taken into account. The Breit interaction and QED effects were also estimated. The uncertainties of calculated IPs, EAs, and IR for Uus and At were reduced through an extrapolation procedure. The good consistency with available experimental and other theoretical values demonstrates the validity of the present results. These theoretical data therefore can be used to predict some unknown physicochemical properties of element Uus, Astatine, and their compounds.

  9. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  10. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  11. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  12. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  13. 200 aastat kunstiharidust Eestis

    Index Scriptorium Estoniae

    2002-01-01

    5. XII tähistati TÜ kunstimuuseumis 200 aasta möödumist professionaalse kunstihariduse algusest Eestis. Avati kunstinäitus, esitleti kataloogi "200 aastat kunstiharidust Eestis - Tartu Ülikooli joonistuskool 1803-1893"

  14. GEN 200 Courses/sanptutorial

    OpenAIRE

    2015-01-01

    GEN 200 Week 1 Assignment- Map Out an Important Goal GEN 200 Week 1 DQ 1 GEN 200 Week 1 DQ 2 GEN 200 Week 2 Assignment- Communication and Collaboration Strategy Paper GEN 200 Week 2 DQ 1 GEN 200 Week 2 DQ 2 GEN 200 Week 3 Assignment- Student Web Scavenger Hunt GEN 200 Week 3 DQ 1 GEN 200 Week 3 DQ 2 GEN 200 Week 4 Assignment-Research Strategy Paper GEN 200 Week 4 DQ 1 GEN 200 Week 4 DQ 2 GEN 200 Week 5 DQ 1 GEN 200 Week 5 DQ 2 GEN 200 We...

  15. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  16. PHI 200 Course Tutorial / Snaptutorial

    OpenAIRE

    Pascal

    2015-01-01

    For more classes visit www.snaptutorial.com PHI 200 Week 2 DQ 1 Ethics and Relativism PHI 200 Week 2 DQ 2 Animal Rights PHI 200 Week 2 Written Assignment Assisted Suicide PHI 200 Week 3 DQ 1 The Limits of Skepticism PHI 200 Week 3 DQ 2 Creationism and Science PHI 200 Week 3 Written Assignment Final Paper (Death Penalty) PHI 200 Week 4 DQ 1 Proof of God's Existence PHI 200 Week 4 DQ 2 The Turing Test PHI 200 Week 4 Quiz PHI 200 Week 5 DQ 1 The Va...

  17. Comment: 200 [Taxonomy Icon

    Lifescience Database Archive (English)

    Full Text Available Japanese tree frog Hyla japonica Hyla_japonica_L.png 200.png Takeru Nakazato (Database Center for Life...合データベースセンター) Photo: Takeru Nakazato (Database Center for Life Science) nakazato 2009/11/04 17:26:47 2010/01/14 20:11:35 ...

  18. Hans Christian Andersen 200

    Index Scriptorium Estoniae

    2005-01-01

    Hollandi lasteraamatute autorist ja illustraatorist Max Velthuijs'ist (1923-2005). H.C. Anderseni 200. sünniaastapäevale pühendatud lasteraamatunäitusest Rahvusraamatukogus. Eksponeeritakse ka Tiina Reinsalu akvarelle raamatule "Ööbik"

  19. Deutsch 100, 200, 300.

    Science.gov (United States)

    Manitoba Dept. of Education, Winnipeg.

    Manitoba's curriculum guide for German 100, 200, and 300 is designed to (1) make teachers of these courses aware of the official policy concerning the nature, goals, and objectives of the courses and approved teaching materials, and (2) provide instructional guidelines. The guide provides information about three sets of teaching materials from…

  20. Status of EXO-200

    CERN Document Server

    Ackerman, Nicole

    2009-01-01

    EXO-200 is the first phase of the Enriched Xenon Observatory (EXO) experiment, which searches for neutrinoless double beta decay in 136Xe to measure the mass and probe the Majorana nature of the neutrino. EXO-200 consists of 200 kg of liquid Xe enriched to 80% in 136Xe in an ultra-low background TPC. Energy resolution is enhanced through the simultaneous collection of scintillation light using Large Area Avalanche Photodiodes (LAAPD's) and ionization charge. It is being installed at the WIPP site in New Mexico, which provides a 2000 meter water-equivalent overburden. EXO-200 will begin taking data in 2009, with the expected two-year sensitivity to the half-life for neutrinoless double beta decay of 6.4 10^25 years. According to the most recent nuclear matrix element calculations, this corresponds to an effective Majorana neutrino mass of 0.13 to 0.19 eV. It will also measure the two neutrino mode for the first time in 136Xe.

  1. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  2. Hanford 200 Areas Development Plan

    Energy Technology Data Exchange (ETDEWEB)

    Rinne, C.A.; Daly, K.S.

    1993-08-01

    The purpose of the Hanford 200 Areas Development Plan (Development Plan) is to guide the physical development of the 200 Areas (which refers to the 200 East Area, 200 West Area, and 200 Area Corridor, located between the 200 East and 200 West Areas) in accordance with US Department of Energy (DOE) Order 4320.lB (DOE 1991a) by performing the following: Establishing a land-use plan and setting land-use categories that meet the needs of existing and proposed activities. Coordinating existing, 5-year, and long-range development plans and guiding growth in accordance with those plans. Establishing development guidelines to encourage cost-effective development and minimize conflicts between adjacent activities. Identifying site development issues that need further analysis. Integrating program plans with development plans to ensure a logical progression of development. Coordinate DOE plans with other agencies [(i.e., Washington State Department of Ecology (Ecology) and US Environmental Protection Agency (EPA)]. Being a support document to the Hanford Site Development Plan (DOE-RL 1990a) (parent document) and providing technical site information relative to the 200 Areas.

  3. An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211

    Energy Technology Data Exchange (ETDEWEB)

    O’Hara, Matthew J.; Krzysko, Anthony J.; Niver, Cynthia M.; Morrison, Samuel S.; Owsley, Stanley L.; Hamlin, Donald K.; Dorman, Eric F.; Scott Wilbur, D.

    2017-04-01

    Astatine-211 (211At) is a promising cyclotron-produced radionuclide being investigated for use in targeted alpha therapy of blood borne and metastatic cancers, as well as treatment of tumor remnants after surgical resections. The isolation of trace quantities of 211At, produced within several grams of a Bi metal cyclotron target, involves a complex, multi-step procedure: (1) Bi metal dissolution in strong HNO3, (2) distillation of the HNO3 to yield Bi salts containing 211At, (3) dissolution of the salts in strong HCl, (4) solvent extraction of 211At from bismuth salts with diisopropyl ether (DIPE), and (5) back-extraction of 211At from DIPE into NaOH, leading to a purified 211At product. Step (1) has been addressed first to begin the process of automating the onerous 211At isolation process. A computer-controlled Bi target dissolution system has been designed. The system performs in-line dissolution of Bi metal from the target assembly using an enclosed target dissolution block, routing the resulting solubilized 211At/Bi mixture to the subsequent process step. The primary parameters involved in Bi metal solubilization (HNO3 concentration and influent flow rate) were optimized prior to evaluation of the system performance on replicate cyclotron irradiated targets. The results indicate that the system performs reproducibly, having nearly quantitative release of 211At from irradiated targets, with cumulative 211At recoveries that follow a sigmoidal function. The predictable nature of the 211At release profile allows the user to tune the system to meet target processing requirements.

  4. Penfigoide anti p-200 Anti-p200 pemphigoid

    OpenAIRE

    T Zarowsky

    2011-01-01

    Se efectúa una revisión del penfigoide ampollar anti-P200 desde el punto de vista clínico, histopatológico, inmunológico como su tratamiento y múltiples diagnósticos diferenciales.A review of the anti-P200 pemphigoid from the clinical, histopathological, immunological are updated, as well assess to its treatment and various differentials diagnosis.

  5. Penfigoide anti p-200 Anti-p200 pemphigoid

    Directory of Open Access Journals (Sweden)

    T Zarowsky

    2011-06-01

    Full Text Available Se efectúa una revisión del penfigoide ampollar anti-P200 desde el punto de vista clínico, histopatológico, inmunológico como su tratamiento y múltiples diagnósticos diferenciales.A review of the anti-P200 pemphigoid from the clinical, histopathological, immunological are updated, as well assess to its treatment and various differentials diagnosis.

  6. 200 GW for Germany; 200 Gigawatt fuer Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Fuhs, Michael; Enkhardt, Sandra

    2012-11-01

    200 GW of solar power, i.e. seven times as much as today: Is that a realistic goal, or is it just propaganda for a lobby intending to make a good life for manufacturers and fitters? There is much to suggest that it may be a socially relevant goal.

  7. CMS silicon tracker milestone 200

    CERN Document Server

    Dierlamm, A

    2002-01-01

    The tracker of CMS will fully consist of silicon micro-strip and pixel sensors. Building a detector with 210 m/sup 2/ sensor surface in about 3 years requires a tightly controlled construction schedule. All different aspects of the production are exercised within a pre- production of 200 modules (Milestone 200) to identify and eliminate possible bottlenecks and to test the complete electronic chain. The quality, process stability and radiation hardness of the silicon sensors will be permanently monitored. Automatic assembly procedure and industrial bonding machines will guarantee a fast and reliable construction. All modules will be tested for signal, noise and pedestals at room temperature and operation temperature of -10 degrees C. Quality assurance of the Milestone 200 sensors and modules including irradiation and stability tests are presented. (6 refs).

  8. PHI 200 ASH Course Tutorial/ Tutorialrank

    OpenAIRE

    john

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 5 Times, Rating: A+   PHI 200 Week 2 DQ 1 Ethics and Relativism PHI 200 Week 2 DQ 2 Animal Rights PHI 200 Week 2 Written Assignment Assisted Suicide PHI 200 Week 3 DQ 1 The Limits of Skepticism PHI 200 Week 3 DQ 2 Creationism and Science PHI 200 Week 3 Written Assignment Final Paper (Death Penalty) PHI 200 Week 4 DQ 1 Proof of God's Existence PHI 200 Week 4 DQ 2 The Tu...

  9. Analisis dan Optimasi Desain Sistem Reaktor Gas Temperatur Tinggi RGTT200K dan RGTT200KT

    Directory of Open Access Journals (Sweden)

    Mohammad Dhandhang Purwadi

    2013-03-01

    dengan penyelesaian persamaan aljabar linier dari model RGTT200K dan RGTT200KT. Dari analisis dan optimasi ini dihasilkan desain konseptual sistem RGTT200K dan RGTT200KT dengan spesifikasi thermal-flow teras sama, dan peningkatan EUF dari 63% menjadi 80,14% (untuk RGTT200K dan dari 63,6% menjadi 78,02% (untuk RGTT200KT.

  10. 17 CFR 200.70 - Business promotions.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Business promotions. 200.70 Section 200.70 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.70 Business promotions. A member...

  11. 17 CFR 200.552 - NEPA planning.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false NEPA planning. 200.552 Section 200.552 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT... § 200.552 NEPA planning. Where it is reasonably foreseeable by the Commission that it may be required...

  12. 10 CFR 1021.200 - DOE planning.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false DOE planning. 1021.200 Section 1021.200 Energy DEPARTMENT... Decisionmaking § 1021.200 DOE planning. (a) DOE shall provide for adequate and timely NEPA review of DOE... accordance with 40 CFR 1501.2 and this section. In its planning for each proposal, DOE shall include...

  13. 49 CFR 195.200 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.200 Section 195.200 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.200 Scope. This subpart prescribes minimum requirements for constructing...

  14. 7 CFR 59.200 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Definitions. 59.200 Section 59.200 Agriculture... REPORTING Swine Reporting § 59.200 Definitions. The following definitions apply to this subpart. Affiliate... in which the pricing mechanism is a formula price based on any market other than the market for...

  15. 34 CFR 200.17 - Intermediate goals.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Intermediate goals. 200.17 Section 200.17 Education... Programs Operated by Local Educational Agencies Adequate Yearly Progress (ayp) § 200.17 Intermediate goals. Each State must establish intermediate goals that increase in equal increments over the period...

  16. 42 CFR 400.200 - General definitions.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false General definitions. 400.200 Section 400.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS INTRODUCTION; DEFINITIONS Definitions § 400.200 General definitions. In this chapter, unless...

  17. 38 CFR 200.3 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Responsibilities. 200.3 Section 200.3 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.3 Responsibilities. (a) The COO is the AFRH NEPA...

  18. 20 CFR 200.6 - Open meetings.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Open meetings. 200.6 Section 200.6 Employees' Benefits RAILROAD RETIREMENT BOARD GENERAL ADMINISTRATION GENERAL ADMINISTRATION § 200.6 Open meetings. (a) Definitions—(1) Meeting. For purposes of this section, the term “meeting” shall mean the deliberations of...

  19. 17 CFR 200.400 - Open meetings.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Open meetings. 200.400 Section 200.400 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT... Meetings § 200.400 Open meetings. Except as otherwise provided in this subpart, meetings of the...

  20. 49 CFR 179.200-10 - Welding.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Welding. 179.200-10 Section 179.200-10... Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-10 Welding. (a) All joints... W (IBR, see § 171.7 of this subchapter). Welding procedures, welders and fabricators shall...

  1. 42 CFR 421.200 - Carrier functions.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Carrier functions. 421.200 Section 421.200 Public...) MEDICARE PROGRAM MEDICARE CONTRACTING Carriers § 421.200 Carrier functions. A contract between CMS and a carrier specifies the functions to be performed by the carrier. The contract may include any or all of...

  2. 44 CFR 206.200 - General.

    Science.gov (United States)

    2010-10-01

    ... to State and Local Governments,” published at 44 CFR part 13, place requirements on the State in its... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false General. 206.200 Section 206.200 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF...

  3. 24 CFR 200.605 - Authority.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Authority. 200.605 Section 200.605 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN...

  4. 24 CFR 200.600 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Purpose. 200.600 Section 200.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN...

  5. 24 CFR 200.635 - Compliance.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Compliance. 200.635 Section 200.635 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN...

  6. 21 CFR 1311.200 - Pharmacy responsibilities.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Pharmacy responsibilities. 1311.200 Section 1311... ORDERS AND PRESCRIPTIONS (Eff. 6-1-10) Electronic Prescriptions § 1311.200 Pharmacy responsibilities. (a) Before initially using a pharmacy application to process controlled substance prescriptions, the...

  7. 17 CFR 200.505 - Original classification.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Original classification. 200...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Classification and Declassification of National Security Information and Material § 200.505 Original classification. (a) No Commission Member or employee has...

  8. 17 CFR 200.506 - Derivative classification.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Derivative classification. 200...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Classification and Declassification of National Security Information and Material § 200.506 Derivative classification. Any document that includes...

  9. 13 CFR 130.200 - Eligible entities.

    Science.gov (United States)

    2010-01-01

    ... or university; (3) A college or school of business, engineering, commerce or agriculture; (4) A... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Eligible entities. 130.200 Section 130.200 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS...

  10. 42 CFR 93.200 - Administrative action.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Administrative action. 93.200 Section 93.200 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  11. 17 CFR 200.64 - Judicial review.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Judicial review. 200.64... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.64 Judicial review. The Congress has provided for review by the courts of the decisions and orders by this Commission. Members should...

  12. 24 CFR 200.78 - Energy conservation.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Energy conservation. 200.78 Section... Eligibility Requirements for Existing Projects Property Requirements § 200.78 Energy conservation. Construction, mechanical equipment, and energy and metering selections shall provide cost effective...

  13. 15 CFR 200.100 - Statutory functions.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Statutory functions. 200.100 Section..., PROCEDURES, AND FEES § 200.100 Statutory functions. (a) The National Institute of Standards & Technology (NIST) has been assigned the following functions (15 U.S.C. 271 et seq.): (1) The custody,...

  14. 17 CFR 200.660 - Communications.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Communications. 200.660 Section 200.660 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... Communications. (a) The agency shall take appropriate steps to ensure effective communication with...

  15. 7 CFR 1710.200 - Purpose.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Purpose. 1710.200 Section 1710.200 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE... borrower's future requirements for energy and capacity. The load forecast of a power supply...

  16. 24 CFR 200.73 - Property development.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Property development. 200.73 Section 200.73 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment,...

  17. Results and Status of EXO-200

    Science.gov (United States)

    Daniels, Tim; Kaufman, Lisa; EXO-200 Collaboration

    2016-09-01

    EXO-200 has provided one of the most sensitive searches for neutrinoless double-beta decay utilizing 175 kg of enriched liquid xenon in an ultra-low background time projection chamber. This detector has demonstrated excellent energy resolution and background rejection capabilities. Using the first two years of data, EXO-200 has set a limit of 1 . 1 ×1025 y at 90% C.L. on the neutrinoless double-beta decay half-life of Xe136. The experiment has experienced a brief hiatus in data taking during a temporary shutdown of its host facility: the Waste Isolation Pilot Plant. EXO-200 has resumed data taking in earnest with upgraded detector electronics. Results from the analysis of EXO-200 data and an update on the current status of EXO-200 will be presented.

  18. Result from, and status of, EXO-200

    Science.gov (United States)

    MacLellan, Ryan; EXO-200 Collaboration

    2016-03-01

    EXO-200 has provided one of the most sensitive searches for neutrinoless double-beta decay utilizing 175kg of enriched liquid xenon in an ultra-low background time projection chamber. This detector has demonstrated excellent energy resolution and background rejection capabilities. Using the first two years of data, EXO-200 has set a limit of 1 . 1 ×1025 y at 90% C.L. on the neutrinoless double-beta decay half-life of 136Xe. The experiment has experienced a brief hiatus in data taking during a temporary shutdown of its host facility: the Waste Isolation Pilot Plant. EXO-200 expects to resume data taking in earnest this fall with upgraded detector electronics. Results from the analysis of EXO-200 data and an update on the current status of EXO-200 will be presented.

  19. 24 CFR 200.610 - Policy.

    Science.gov (United States)

    2010-04-01

    ... GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.610 Policy. It... programs shall pursue affirmative fair housing marketing policies in soliciting buyers and tenants,...

  20. 24 CFR 200.615 - Applicability.

    Science.gov (United States)

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.615 Applicability. The affirmative fair housing marketing requirements, as set forth in paragraphs (a) through...

  1. Gogol 200 : teatraliseeritud kirjandustund / Reet Kudu

    Index Scriptorium Estoniae

    Kudu, Reet, 1949-

    2009-01-01

    4. aprillil Tallinnas Vene Kultuurikeskuses toimunud teatriõhtust "200 aastat koos Nikolai Gogoliga", mille stsenarist on Lidia Golovataja ja režissöör Jevgeni Gaitšuk. Loe ka: Kes on geeniuse sõbrad?

  2. 200 Irish students at CERN - virtually!

    CERN Document Server

    2003-01-01

    On 6 October, 200 physics students from schools around Ireland paid a virtual visit to CERN and met several CERN scientists, with the help of the latest video conferencing technology using high-speed internet lines.

  3. 7 CFR 205.200 - General.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and Handling Requirements § 205.200 General....

  4. 200 million Euros:Worthy or Not?

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    "Pierre Cardin to Sell Licenses to Chinese Companies with 200 million Euros",frankly speaking,at the first time I knew the news,several questions ran into my mind:"200 million Euros,is it too much for such a not-first-class international fashion brand?","200 millions Euros,with such a large amount of capital,domestic enterprises could gain more investment to develop their own brand?",or"Pierre Cardin…".Although later one of the spokesman of Pierre Cardin Group explained:"This is not about the sale of the Pierre Cardin group,but the sale of certain licenses in China",this hot deal still arouse fierce comments from not only the domestic industrial insiders,but also the publics.

  5. 200 North Aggregate Area source AAMS report

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This report presents the results of an aggregate area management study (AAMS) for the 200 North Aggregate Area in the 200 Areas of the US Department of Energy (DOE) Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past practice investigations.

  6. 17 CFR 200.2 - Statutory functions.

    Science.gov (United States)

    2010-04-01

    ... AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management § 200.2 Statutory... interest and the interest of investors and consumers. The Act generally limits a public-utility holding... represent the debtors by proscribing certain relationships that could conflict with proper exercise...

  7. 13 CFR 500.200 - Eligible Borrower.

    Science.gov (United States)

    2010-01-01

    ... available to it under reasonable terms or conditions sufficient to meet its financing needs, as reflected in... 500.200 Business Credit and Assistance EMERGENCY OIL AND GAS GUARANTEED LOAN BOARD EMERGENCY OIL AND... the General Accounting Office and an independent auditor acceptable to the Board prior to the...

  8. 13 CFR 400.200 - Eligible Borrower.

    Science.gov (United States)

    2010-01-01

    ... terms or conditions sufficient to meet its financing needs, as reflected in the financial and business... 400.200 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE... an independent auditor acceptable to the Board prior to the issuance of the guarantee and while...

  9. 24 CFR 200.620 - Requirements.

    Science.gov (United States)

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.620... marketing responsibility to another party, be responsible for that party's carrying out the requirements: (a... marketing program shall be in effect for each multifamily project throughout the life of the mortgage....

  10. 21 CFR 131.200 - Yogurt.

    Science.gov (United States)

    2010-04-01

    ...) Concentrated skim milk, nonfat dry milk, buttermilk, whey, lactose, lact-al-bum-ins, lacto-globulins, or whey... CONSUMPTION MILK AND CREAM Requirements for Specific Standardized Milk and Cream § 131.200 Yogurt. (a... of bulky flavors, contains not less than 3.25 percent milkfat and not less than 8.25 percent...

  11. Uitgelicht: Familienamen en 200 jaar burgerlijke stand.

    NARCIS (Netherlands)

    Brouwer, L.

    2011-01-01

    Dit jaar bestaat de burgerlijke stand 200 jaar en gezien de efficiëntie van de persoonsregistratie die bewerkstelligd is, mogen we daar best stil bij blijven staan. We zien dan ook dat er onder andere op de archieven in den lande uitgebreid aandacht aan wordt besteed. Hier op het Meertens Instituut

  12. 24 CFR 200.105 - Mortgagor supervision.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgagor supervision. 200.105... supervision. (a) As long as the Commissioner is the insurer or holder of the mortgage, the Commissioner shall... Regulatory Agreement or other instrument granting the Commissioner supervision of the mortgagor....

  13. 15 CFR 200.108 - Request procedure.

    Science.gov (United States)

    2010-01-01

    ..., PROCEDURES, AND FEES § 200.108 Request procedure. (a) A formal purchase order for the calibration or test should be sent before or at the time the instrument or standard is shipped. The purchase order should... by purchase order or by letter or document authorizing the cost of the work to be billed to...

  14. 200 aastat klassikalist filoloogiat / Ivo Volt

    Index Scriptorium Estoniae

    Volt, Ivo, 1975-

    2003-01-01

    Detsembris tähistati kollokviumiga 200 a. möödumist klassikalise filoloogia eriala sünnist Eestis. Ettekannetega esinesid ka Mati Unt ja Mari Murdvee (antiikautorite tekstide esitamisvõimalustest teatrilaval), Jüri Talvet ja Jaan Unt

  15. 34 CFR 200.90 - Program definitions.

    Science.gov (United States)

    2010-07-01

    ... Intervention Programs for Children and Youth Who are Neglected, Delinquent, or At-Risk of Dropping Out § 200.90...) in an institution or a community day program for neglected or delinquent children that consists of... community day program or school not operated by the State that serves delinquent children and youth....

  16. 50 CFR 300.200 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Definition of Illegal, Unreported, or Unregulated Fishing § 300.200 Purpose. The purpose of this subpart is... Reauthorization Act of 2006 (“Act”) to publish a definition of the term “Illegal, unreported, or...

  17. 38 CFR 52.200 - Physical environment.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Physical environment. 52...) PER DIEM FOR ADULT DAY HEALTH CARE OF VETERANS IN STATE HOMES Standards § 52.200 Physical environment. The physical environment must be designed, constructed, equipped, and maintained to protect the...

  18. 38 CFR 200.2 - Background.

    Science.gov (United States)

    2010-07-01

    ... NATIONAL ENVIRONMENTAL POLICY ACT § 200.2 Background. (a) The NEPA and the Council on Environmental Quality... actions (activities, programs, projects, legislation) and any reasonable alternatives on the environment... the decision is made about whether and how to proceed with the action. Relevant...

  19. Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis.

    Science.gov (United States)

    Pruszyński, Marek; Bilewicz, Aleksander; Zalutsky, Michael R

    2008-04-01

    The goal of this study was to evaluate a new approach that can be applied for labeling biomolecules with (211)At. Many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking different (211)At labeling strategies. The approach evaluated in this study was to attach astatide anions to soft metal cations, which are also complexed by a bifunctional ligand. Ultimately, this complex could in principle be subsequently conjugated to a biomolecule with the proper selection of ligand functionality. We report here the attachment of (211)At(-) and *I(-) (*I = (131)I or (125)I) anions to the soft metal cations Rh(III) and Ir(III), which are complexed by the 1,5,9,13-tetrathiacyclohexadecane-3,11-diol (16aneS4-diol) ligand. Radioactive *I(-) anions were used for preliminary studies directed at the optimization of reaction conditions and to provide a baseline for comparison of results with (211)At. Four complexes Rh[16aneS4-diol]*I/(211)At and Ir[16aneS4-diol]*I/(211)At were synthesized in high yield in a one-step procedure, and the products were characterized mainly by paper electrophoresis and reversed-phase HPLC. The influences of time and temperature of heating and concentrations of metal cations and sulfur ligand 16aneS4-diol, as well as pH on the reaction yields were determined. Yields of about 80% were obtained when the quantities of Rh(III) or Ir(III) cations and 16aneS4-diol ligand in the solutions were 62.5 nmol and 250 nmol, respectively, and the pH ranged 3.0-4.0. Syntheses required heating for 1-1.5 h at 75-80 degrees C. The influence of microwave heating on the time and completeness of the complexation reaction was evaluated and compared with the conventional method of heating in an oil bath. Microwave synthesis accelerates reactions significantly. With microwave heating, yields of about 75% for Rh[16aneS4-diol](131)I and Ir[16aneS4-diol](131)I complexes were obtained after only 20 min exposure of the reaction mixtures to

  20. Neuromuscular Fatigue During 200 M Breaststroke

    Directory of Open Access Journals (Sweden)

    Ana Conceição

    2014-03-01

    Full Text Available The aims of this study were: i to analyze activation patterns of four upper limb muscles (duration of the active and non-active phase in each lap of 200m breaststroke, ii quantify neuromuscular fatigue, with kinematics and physiologic assessment. Surface electromyogram was collected for the biceps brachii, deltoid anterior, pectoralis major and triceps brachii of nine male swimmers performing a maximal 200m breaststroke trial. Swimming speed, SL, SR, SI decreased from the 1st to the 3rd lap. SR increased on the 4th lap (35.91 ± 2.99 stroke·min-1. Peak blood lactate was 13.02 ± 1.72 mmol·l-1 three minutes after the maximal trial. The EMG average rectified value (ARV increased at the end of the race for all selected muscles, but the deltoid anterior and pectoralis major in the 1st lap and for biceps brachii, deltoid anterior and triceps brachii in the 4th lap. The mean frequency of the power spectral density (MNF decreased at the 4th lap for all muscles. These findings suggest the occurrence of fatigue at the beginning of the 2nd lap in the 200m breaststroke trial, characterized by changes in kinematic parameters and selective changes in upper limb muscle action. There was a trend towards a non-linear fatigue state.

  1. EXO-200 results and cosmogenic backgrounds

    Science.gov (United States)

    Belov, V. A.; EXO-200 collaboration

    2017-01-01

    Status update and recent results from the double beta decay search experiment EXO-200 are presented. Detector is a liquid xenon TPC with charge and light readout located underground in low-background laboratory at 1600 m.w.e. depth. It contains 175 kg of xenon with 80.6% abundance of 136Xe, which acts as both the decaying nucleus and detection medium. Detector showed good performance and achieved remarkable results. The detector has demonstrated excellent energy resolution and background rejection capabilities and has set a lower limit on the 0νββ-decay half-life of 1.1 × 1025 years at 90% C.L. in early 2014. The EXO-200 collaboration has since published several papers on experimental backgrounds and searches for rare or exotic processes. After a two-year data interruption, EXO-200 is now back online with significant hardware improvements, including a radon reduction air system and a front end electronics upgrade for better energy resolution.

  2. Os 200 anos da pilha elétrica The 200 years of the electric pile

    Directory of Open Access Journals (Sweden)

    Aécio Pereira Chagas

    2000-06-01

    Full Text Available In celebration of the 200th anniversary of the electric pile, invented by Alessandro Volta, a synopsis of his letter to The Royal Society (London and of his biography is presented.

  3. STUDY OF 200 CASES OF PLEURAL FLUID

    Directory of Open Access Journals (Sweden)

    Ramakrishna R

    2016-09-01

    Full Text Available BACKGROUND We have studied 200 patients of pleural fluid presenting to our tertiary care centre. Presence of cases of pleural fluid is a common presentation both in pulmonary and extrapulmonary diseases. We analysed the patients having both exudates and transudates and studied the results. MATERIALS AND METHODS We selected patients above 20 years of age and classified the patients with pleural fluid as having transudates and exudates. We studied the causes of transudates and exudates. A total of 200 patients are studied in this prospective study. Diagnosis of pleural exudates is made on the basis of Light’s criteria, chest x-ray, pleural fluid analysis, CT scan in selected patients, sputum examination, bronchoscopy and bronchial washings. Moribund and non-cooperative patients and HIV positives were excluded from the study. RESULTS Among the 200 patients, 91% have exudates. 9% have transudates by Light’s criteria. Tuberculosis is the commonest cause of effusions (64.83% followed by malignancy (13.73% and sympneumonic or parapneumonic effusions (9.89%. Pleural effusions occurred predominantly in males. Prevalence of diabetes Mellitus among cases of tuberculous pleural effusions is 13.56%. Tuberculous effusions are predominantly right-sided. CONCLUSION Predominant cases of pleural fluid are exudates. Commonest cause of pleural effusion is Tuberculosis followed by malignancy both pulmonary and extrapulmonary and sym. and parapneumonic effusions. Prevalence of Diabetes among Tuberculous pleural effusion cases is more or less same as in general population. Cough, expectoration fever, chest pain and breathlessness are the common symptoms occurring in three fourths of the patients of tuberculous pleural effusion. Most of the cases of Tuberculous effusion are above 30 years of age. In the diagnosis of tuberculous pleural effusion, Pleural fluid ADA is very important. Pleural fluid cytology, pleural biopsy, bronchoscopy, bronchial washings and sputum

  4. Superhigh-resolution 200ppi series TFT-LCDs; Chokoseisai 200ppi ekisho display series

    Energy Technology Data Exchange (ETDEWEB)

    Kawamata, K.; Hirai, H. [Toshiba Corp., Tokyo (Japan)

    2000-02-01

    We have developed a 202 pixels per inch (ppi) thin-film transistor liquid crystal display (TFT-LCD) using low-temperature polycrystalline silicon (LTPS) technology. The superhigh resolution of 202 ppi offers the same image quality as printed matter such as magazines. The 200 ppi series TFT-LCDs are expected to support further developments in such areas as electronic books (e-books) and personal digital-picture viewers. Our lineup of 200 ppi TFT-LCDs includes a 4-inch display with VGA resolution, which is suitable for palmtop-size applications, and a 6.3-inch display with XGA resolution, which is suitable for typical photograph or paperback book-size applications. Larger size LCDs with 200 ppi resolution will be developed. (author)

  5. Hunting virtual LSPs at LEP 200

    CERN Document Server

    Datta, A; Drees, Manuel; Datta, A; Guchait, M; Drees, M

    1995-01-01

    Relatively light sneutrinos, which are experimentally allowed, may significantly affect the currently popular search strategies for supersymmetric particles by decaying dominantly into an invisible channel. In certain cases the second lightest neutralino may also decay invisibly leading to two extra carriers of missing energy -- in addition to the lightest supersymmetric particle (LSP) \\zi\\ -- the virtual LSPs (VLSPs). It is shown that these VLSPs are allowed in supergravity models with common scalar and gaugino masses at the unification scale for a sizable region of parameter space and are consistent with all constraints derived so far from SUSY searches. The pair production of right handed sleptons, which can very well be the lightest charged SUSY particles in this scenario, at LEP 200 and their decay signatures are discussed. The signal survives kinematical cuts required to remove the standard model background. Charginos are also pair produced copiously if kinematically accessible; they also decay dominant...

  6. Feasibility study of a 200 ampere battery

    Science.gov (United States)

    Baldwin, A. R.

    1991-06-01

    The results of a Sandia National Laboratories program to design and develop a high-current thermal battery for the Hypersonic Weapons Technology Program are presented. The feasibility of a 200 A, 150 s, 12 Vdc primary battery was demonstrated under ambient conditions. New header feedthrough design concepts were used, and new internal current collectors and internal power leads were considered. The Li(Si)/LiBr-LiCl-LiF/FeS2 electrochemical system has shown exceptional performance at the high-current operation conditions. A high-rate Zinc/Silver Oxide secondary cell was also evaluated, and the results are presented in this report. These cells exhibited excellent high-rate discharge performance.

  7. 200,000 jobs with reduced energy consumption; 200.000 Jobs mit weniger Energie

    Energy Technology Data Exchange (ETDEWEB)

    Wedekind, K.

    2007-07-15

    Modernisation of heating systems is still going slow in Germany. Most heating systems are still more than 20 years old. They consume too much energy and pollute the environment. The industrial association BDH intends to speed up the process and create 200,000 new jobs. (orig.)

  8. Earth Surface Patterns in 200 Years (Invited)

    Science.gov (United States)

    Werner, B.

    2009-12-01

    What kinds of patterns will characterize Earth's surface in 200 years? This question is addressed using a complex systems dynamical framework for distinct levels of description in a hierarchy, in which time scale and spatial extent increase and number of variables decrease with level, and in which levels are connected nonlinearly to each other via self-organization and slaving and linearly to the external environment. Self-organized patterns linking the present to 200 years in the future must be described dynamically on a level with a time scale of centuries. Human-landscape coupling will play a prominent role in the formation of these patterns as population peaks and interactions become nonlinear over these time scales. Three related examples illustrate this approach. First, the response of human-occupied coastlines to rising sea level. Coastlines in wealthy regions develop a spatially varying boom and bust pattern, with response amplified by structures meant to delay the effects of sea level rise. Coastlines in economically disadvantaged regions experience a subdued response, with populations developing a culture of displacement that minimizes human-landscape interactions in a context of scarce resources. Second, the evolution of nation-state borders with degrading ecosystems, declining resource availability and increasing transportation costs. The maintenance of strong borders as selective filtration systems (goods, capital and people) is based on a cost-benefit analysis in which the economic benefits accruing from long distance, globalized resource exploitation are weighed against policing and infrastructure costs. As costs rise above benefits, borders fragment, with a transition to local barriers and conflicts, and mobile peoples moving to resources. Third, trends in urbanization and development of megacities under economic and environmental stress. The pattern of rapid growth of megacities through inward migration, with displaced people occupying high

  9. Laparoscopic Cholecystectomy: An Experience of 200 cases

    Directory of Open Access Journals (Sweden)

    Sanjay K. Bhasin, J.G. Langer.

    2004-04-01

    Full Text Available The surgical management of gallstones has been revolutionized after the advent of laparoscopiccholecystectomysince 1985/87. This minimally invasive technique has virtually become the goldstandard in the management of cholelithiasis. We share our experience of 200 cases of laparoscopiccholecystectomyperformed in symptomatic cholelithiasis over a period of five years from 1998 to2002 in Govt. Medical College, Jammu. There were 32 males and 168 females in the study group.Maximum age of the patients was 65-yr and minimum 17-yr. Patients with high-risk medical problems;deranged LFT, CBD stones and acute cholecystitis were excluded from this study. Average operationtime was 61.3 minute (40-130 mt, post-operative analgesic used were 3.02 doses per patient (2-15doses, post-operative hospital stay was 4.34 days (2-26 days and time to return to work was 13.2days (10-40 days. Rate of conversion to conventional-cholecystectomy was 4%. There was nomortality and negligible/acceptable morbidity. No complications were observed in the follow up periodranging from 2 weeks to 6 months. The patients were quite satisfied with the outcome of the procedure.

  10. 40 CFR 246.200 - High-grade paper recovery.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false High-grade paper recovery. 246.200 Section 246.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE... paper recovery....

  11. 40 CFR 246.200-7 - Recommended procedures: Transportation.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommended procedures: Transportation. 246.200-7 Section 246.200-7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 246.200-7 Recommended procedures: Transportation. Transportation to market may be supplied by...

  12. 17 CFR 200.26a - Office of Information Technology.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Office of Information Technology. 200.26a Section 200.26a Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Organization § 200.26a Office of Information Technology. The Office of Information Technology is...

  13. 7 CFR 948.200 - Accounting and collections.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Accounting and collections. 948.200 Section 948.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Accounting and Collections § 948.200 Accounting and collections. (a) Each handler's assessment account...

  14. 17 CFR 200.72 - Supervision of internal organization.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Supervision of internal organization. 200.72 Section 200.72 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.72 Supervision...

  15. 34 CFR 200.12 - Single State accountability system.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Single State accountability system. 200.12 Section 200... Improving Basic Programs Operated by Local Educational Agencies State Accountability System § 200.12 Single State accountability system. (a)(1) Each State must demonstrate in its State plan that the State...

  16. 24 CFR 200.153 - Presentation of claim.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Presentation of claim. 200.153 Section 200.153 Housing and Urban Development Regulations Relating to Housing and Urban Development... Claims for Losses § 200.153 Presentation of claim. In the event the insured lender is entitled under...

  17. 12 CFR 1806.200 - Community eligibility and designation.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Community eligibility and designation. 1806.200 Section 1806.200 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY BANK ENTERPRISE AWARD PROGRAM Awards § 1806.200 Community eligibility and designation. (a)...

  18. 34 CFR 200.55 - Qualifications of teachers.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Qualifications of teachers. 200.55 Section 200.55... Basic Programs Operated by Local Educational Agencies Qualifications of Teachers and Paraprofessionals § 200.55 Qualifications of teachers. (a) Newly hired teachers in Title I programs. (1) An LEA...

  19. 34 CFR 200.6 - Inclusion of all students.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Inclusion of all students. 200.6 Section 200.6... Basic Programs Operated by Local Educational Agencies Standards and Assessments § 200.6 Inclusion of all...— (A) For each student with a disability, as defined under section 602(3) of the IDEA,...

  20. 17 CFR 200.735-7 - Negotiation for employment.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Negotiation for employment. 200.735-7 Section 200.735-7 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Employees and Former Members and Employees of the Commission § 200.735-7 Negotiation for employment. (a)...

  1. 24 CFR 200.36 - Financial reporting requirements.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Financial reporting requirements. 200.36 Section 200.36 Housing and Urban Development Regulations Relating to Housing and Urban... Regulations § 200.36 Financial reporting requirements. The mortgagor must comply with the financial...

  2. 200 Area Interim Storage Area Technical Safety Requirements

    Energy Technology Data Exchange (ETDEWEB)

    CARRELL, R.D.

    2000-03-15

    The 200 Area Interim Storage Area Technical Safety Requirements define administrative controls and design features required to ensure safe operation during receipt and storage of canisters containing spent nuclear fuel. This document is based on the 200 Area Interim Storage Area, Annex D, Final Safety Analysis Report which contains information specific to the 200 Area Interim Storage Area.

  3. 34 CFR 200.45 - Supplemental educational services.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Supplemental educational services. 200.45 Section 200... Improving Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.45 Supplemental educational services. (a) Definition. “Supplemental educational services” means tutoring and...

  4. 49 CFR 613.200 - Statewide transportation planning and programming.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Statewide transportation planning and programming. 613.200 Section 613.200 Transportation Other Regulations Relating to Transportation (Continued... Transportation Planning and Programming § 613.200 Statewide transportation planning and programming....

  5. 21 CFR 1404.200 - What is a covered transaction?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false What is a covered transaction? 1404.200 Section 1404.200 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Covered Transactions § 1404.200 What is a covered transaction? A covered transaction is...

  6. 20 CFR 1010.200 - What is priority of service?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What is priority of service? 1010.200 Section 1010.200 Employees' Benefits OFFICE OF THE ASSISTANT SECRETARY FOR VETERANS' EMPLOYMENT AND TRAINING... of Service § 1010.200 What is priority of service? (a) As defined in section 2(a) of the JVA (38...

  7. 48 CFR 927.200 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Scope of subpart. 927.200 Section 927.200 Federal Acquisition Regulations System DEPARTMENT OF ENERGY GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patents 927.200 Scope of subpart. When consulting 48 CFR part...

  8. 42 CFR 403.200 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Basis and scope. 403.200 Section 403.200 Public... PROVISIONS SPECIAL PROGRAMS AND PROJECTS Medicare Supplemental Policies § 403.200 Basis and scope. (a... intent of that section is to enable Medicare beneficiaries to identify Medicare supplemental...

  9. 49 CFR 179.200-9 - Compartment tanks.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Compartment tanks. 179.200-9 Section 179.200-9... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-9 Compartment tanks....

  10. 24 CFR 200.21 - Reinsurance of Commissioner held mortgages.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Reinsurance of Commissioner held mortgages. 200.21 Section 200.21 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 200.21 Reinsurance of Commissioner held mortgages. Any mortgage assigned to the Commissioner...

  11. 19 CFR 200.735-103 - Counseling service.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Counseling service. 200.735-103 Section 200.735-103 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION EMPLOYEE RESPONSIBILITIES AND CONDUCT General Provisions § 200.735-103 Counseling service. (a) The Chairman shall appoint a Designated...

  12. 49 CFR 179.200-22 - Test of tanks.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Test of tanks. 179.200-22 Section 179.200-22... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-22 Test of tanks. (a)...

  13. INTEGRATED COI S200 - Hi-NiCalon FIBER WITH AN S200 MATRIX (POLYMER MATRIX COMPOSITE - PMC) / AETB 1

    Science.gov (United States)

    2003-01-01

    INTEGRATED COI S200 - Hi-NiCalon FIBER WITH AN S200 MATRIX (POLYMER MATRIX COMPOSITE - PMC) / AETB 16 (FOAM CORE) / CARBON REINFORCED CYANOESTER (CERAMIC MATRIX COMPOSITE - CMC) HOT STRUCTURE, PANEL 884-1: SAMPLE 1

  14. VASIMR VX-200 thruster throttling optimization from 30 to 200 kW

    Science.gov (United States)

    Squire, Jared; Olsen, Chris; Chang-Diaz, Franklin; Longmier, Benjamin; Ballenger, Maxwell; Carter, Mark; Glover, Tim; McCaskill, Greg

    2012-10-01

    The VASIMR^ VX-200 experimental plasma thruster incorporates a 40 kW helicon plasma source with a 180 kW Ion Cyclotron Heating (ICH) acceleration stage integrated in a superconducting magnet. Argon propellant mass flow is injected up to 140 mg/s. Rapid plasma start up ( 10^5 liters/s) in a 150 m^3 vacuum chamber achieve performance measurements with the charge exchange mean-free-path greater than 1 m in the background neutral gas (pressure < 10-5 Torr). The thruster efficiency at 200 kW total power is 72 ± 9%, the ratio of effective jet power to input RF power, with an Isp = 4900 ± 300 seconds (flow velocity of 49 km/s), and an ion flux of 1.7 ± 0.1 x 10^21/s. The thrust increases steadily with power to 5.8 ± 0.4 N until the power is maximized and there is no indication of saturation. The plasma density near the device exit exceeds 10^18 m-3 with a power density over 5 MW/m^2. An extensive study of thruster performance, efficiency and thrust-to-power ratio, as a function of Ar propellant flow rate and ICH-to-helicon RF power ratio has been carried out over a total power range of 30 to 200 kW. Optimized throttling set points are determined. The experimental configuration and results of this study are presented.

  15. 200-BP-5 operable unit treatability test report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    The 200-BP-5 Operable Unit was established in response to recommendations presented in the 200 East Groundwater Aggregate Area Management Study Report (AAMSR) (DOE-RL 1993a). Recognizing different approaches to remediation, the groundwater AAMSR recommended separating groundwater from source and vadose zone operable units and subdividing 200 East Area groundwater into two operable units. The division between the 200-BP-5 and 200-PO-1 Operable Units was based principally on source operable unit boundaries and distribution of groundwater plumes derived from either B Plant or Plutonium/Uranium Extraction (PUREX) Plant liquid waste disposal sites.

  16. miR-200 family and its mechanism%miR-200及其作用机制

    Institute of Scientific and Technical Information of China (English)

    苏娟; 张庆瑜

    2011-01-01

    miR-200是一簇与上皮间质转化(EMT)密切相关的微RNA(miRNA)家族,其家族成员包括miR-200a、miR-200b、miR-200c、miR-141及miR-429.miR-200是EMT的主要调节分子并可维持细胞的上皮表型,在EMT的发生和肿瘤的进展过程中发挥重要的作用.%MiR-200 family is a cluster of miRNAs closely linked to EMT. The miR-200 family contains miR-200a, miR-200b, miR-200c, miR-141 and miR-429. Many studies have shown that miR-200 family are key regulators of EMT and determine the epithelial phenotype. They are important to both EMT development and tumor progression. This paper reviews the advancement in the research of miR-200 family and its mechanism.

  17. Super high precision 200 ppi liquid crystal display series; Chokoseido 200 ppi ekisho display series

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    In mobile equipment, in demand is a high precision liquid crystal display (LCD) having the power of expression equivalent to printed materials like magazines because of the necessity of displaying a large amount of information on a easily potable small screen. In addition, with the spread and high-quality image of digital still cameras, it is strongly desired to display photographed digital image data in high quality. Toshiba Corp., by low temperature polysilicone (p-Si) technology, commercialized the liquid crystal display series of 200 ppi (pixels per inch) precision dealing with the rise of the high-precision high-image quality LCD market. The super high precision of 200 ppi enables the display of smooth beautiful animation comparable to printed sheets of magazines and photographs. The display series are suitable for the display of various information services such as electronic books and electronic photo-viewers including internet. The screen sizes lined up are No. 4 type VGA (640x480 pixels) of a small pocket notebook size and No. 6.3 type XGA (1,024x768 pixels) of a paperback size, with a larger screen to be furthered. (translated by NEDO)

  18. Exhaust Plume Measurements of the VASIMR VX-200

    Science.gov (United States)

    Longmier, Benjamin; Bering, Edgar, III; Squire, Jared; Glover, Tim; Chang-Diaz, Franklin; Brukardt, Michael

    2008-11-01

    Recent progress is discussed in the development of an advanced RF electric propulsion concept: the Variable Specific Impulse Magnetoplasma Rocket (VASIMR) VX-200 engine, a 200 kW flight-technology prototype. Results from high power Helicon only and Helicon with ICRH experiments are performed on the VX-200 using argon plasma. Recent measurements of axial plasma density and potential profiles, magnetic field-line shaping, charge exchange, and force measurements taken in the plume of the VX-200 exhaust are made within a new 125 cubic meter cryo-pumped vacuum chamber and are presented in the context of RF plasma thruster physics.

  19. 19 CFR 200.735-113 - Miscellaneous statutory provisions.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Miscellaneous statutory provisions. 200.735-113 Section 200.735-113 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION EMPLOYEE RESPONSIBILITIES... Government Service.” (b) Chapter 11 of Title 18, United States Code, relating to bribery, graft,...

  20. 10 CFR 490.200 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Purpose and scope. 490.200 Section 490.200 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... duty motor vehicles acquired for State fleets be alternative fueled vehicles....

  1. 24 CFR 200.1101 - Cross-reference.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Cross-reference. 200.1101 Section 200.1101 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING...

  2. 24 CFR 200.1001 - Cross-reference.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Cross-reference. 200.1001 Section 200.1001 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING...

  3. 17 CFR 200.61 - Impressions of influence.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Impressions of influence. 200...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.61 Impressions of influence. A... influence him, that any person unduly enjoys his favor or that he is affected in any way by the...

  4. 13 CFR 108.200 - Adequate capital for NMVC Companies.

    Science.gov (United States)

    2010-01-01

    ... VENTURE CAPITAL (âNMVCâ) PROGRAM Qualifications for the NMVC Program Capitalizing A Nmvc Company § 108.200 Adequate capital for NMVC Companies. You must meet the requirements of §§ 108.200-108.230 in order to... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Adequate capital for...

  5. 24 CFR 200.72 - Zoning, deed and building restrictions.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Zoning, deed and building restrictions. 200.72 Section 200.72 Housing and Urban Development Regulations Relating to Housing and Urban... Zoning, deed and building restrictions. The project when completed shall not violate any material...

  6. 24 CFR 14.200 - Contents of application.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Contents of application. 14.200 Section 14.200 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... Agricultural Marketing Act, 12 U.S.C. 1141j(a). (c) If the applicant is a partnership, corporation,...

  7. 24 CFR 200.640 - Effect on other requirements.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Effect on other requirements. 200.640 Section 200.640 Housing and Urban Development Regulations Relating to Housing and...

  8. 24 CFR 200.630 - Notice of housing opportunities.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Notice of housing opportunities. 200.630 Section 200.630 Housing and Urban Development Regulations Relating to Housing and...

  9. 34 CFR 200.61 - Parents' right to know.

    Science.gov (United States)

    2010-07-01

    ... the teacher provides instruction. (2) Whether the teacher is teaching under emergency or other... parent's child has been assigned, or has been taught for four or more consecutive weeks by, a teacher of... 34 Education 1 2010-07-01 2010-07-01 false Parents' right to know. 200.61 Section 200.61...

  10. 38 CFR 200.5 - Coordination with other authorities.

    Science.gov (United States)

    2010-07-01

    ... authorities. 200.5 Section 200.5 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME... explicitly understood that compliance with NEPA does not substitute for compliance with other environmental authorities, nor does compliance with such other authority substitute for compliance with NEPA....

  11. 19 CFR 200.735-120 - Information prohibited.

    Science.gov (United States)

    2010-04-01

    ... professional society or a charitable, religious, social, fraternal, recreational, public service, civic, or... 19 Customs Duties 3 2010-04-01 2010-04-01 false Information prohibited. 200.735-120 Section 200.735-120 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION EMPLOYEE RESPONSIBILITIES...

  12. 24 CFR 401.200 - Who may be a PAE?

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Who may be a PAE? 401.200 Section...-MARKET) Participating Administrative Entity (PAE) and Portfolio Restructuring Agreement (PRA) § 401.200 Who may be a PAE? A PAE must qualify under the definition in section 512(10) of MAHRA. It must...

  13. 49 CFR 179.200-11 - Postweld heat treatment.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Postweld heat treatment. 179.200-11 Section 179.200-11 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... Postweld heat treatment. When specified in § 179.201-1, after welding is complete, postweld heat...

  14. 34 CFR 200.2 - State responsibilities for assessment.

    Science.gov (United States)

    2010-07-01

    ... Disabilities Education Act (IDEA) as compared to all other students; and (vi) Economically disadvantaged... 34 Education 1 2010-07-01 2010-07-01 false State responsibilities for assessment. 200.2 Section 200.2 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY...

  15. 17 CFR 200.22 - The Chief Accountant.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false The Chief Accountant. 200.22... § 200.22 The Chief Accountant. The Chief Accountant of the Commission is the principal adviser to the... administration of the federal securities laws. The Chief Accountant oversees the accounting profession's...

  16. 17 CFR 200.21a - The Ethics Counsel.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false The Ethics Counsel. 200.21a...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General Organization § 200.21a The Ethics Counsel. (a) The Ethics Counsel within the Office of the General Counsel of...

  17. 21 CFR 522.1125 - Hemoglobin glutamer-200 (bovine).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Hemoglobin glutamer-200 (bovine). 522.1125 Section... § 522.1125 Hemoglobin glutamer-200 (bovine). (a) Specifications. Each 125 milliliter bag contains 13 grams per deciliter of polymerized hemoglobin of bovine origin in modified Lactated Ringer's...

  18. miR-200 Regulates Endometrial Development During Early Pregnancy.

    Science.gov (United States)

    Jimenez, Patricia T; Mainigi, Monica A; Word, R Ann; Kraus, W Lee; Mendelson, Carole R

    2016-09-01

    For successful embryo implantation, endometrial stromal cells must undergo functional and morphological changes, referred to as decidualization. However, the molecular mechanisms that regulate implantation and decidualization are not well defined. Here we demonstrate that the estradiol- and progesterone-regulated microRNA (miR)-200 family was markedly down-regulated in mouse endometrial stromal cells prior to implantation, whereas zinc finger E-box binding homeobox-1 and -2 and other known and predicted targets were up-regulated. Conversely, miR-200 was up-regulated during in vitro decidualization of human endometrial stromal cells. Knockdown of miR-200 negatively affected decidualization and prevented the mesenchymal-epithelial transition-like changes that accompanied decidual differentiation. Notably, superovulation of mice and humans altered miR-200 expression. Our findings suggest that hormonal alterations that accompany superovulation may negatively impact endometrial development and decidualization by causing aberrant miR-200 expression.

  19. 21 CFR 200.200 - Prescription drugs; reminder advertisements and reminder labeling to provide price information to...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Prescription drugs; reminder advertisements and... Prescription Drug Consumer Price Listing § 200.200 Prescription drugs; reminder advertisements and reminder labeling to provide price information to consumers. (a) Prescription drug reminder advertisements...

  20. Tumour angiogenesis regulation by the miR-200 family

    Science.gov (United States)

    Pecot, Chad V.; Ivan, Cristina; Lu, Chunhua; Wu, Sherry; Han, Hee-Dong; Shah, Maitri Y.; Rodriguez-Aguayo, Cristian; Bottsford-Miller, Justin; Liu, Yuexin; Kim, Sang Bae; Unruh, Anna; Gonzalez-Villasana, Vianey; Huang, Li; Zand, Behrouz; Moreno-Smith, Myrthala; Mangala, Lingegowda S.; Taylor, Morgan; Dalton, Heather J.; Sehgal, Vasudha; Wen, Yunfei; Kang, Yu; Baggerly, Keith A.; Lee, Ju-Seog; Ram, Prahlad T.; Ravoori, Murali K.; Kundra, Vikas; Zhang, Xinna; Ali-Fehmi, Rouba; Gonzalez-Angulo, Ana-Maria; Massion, Pierre P.; Calin, George A.; Lopez-Berestein, Gabriel; Zhang, Wei; Sood, Anil K.

    2013-01-01

    The miR-200 family is well known to inhibit the epithelial–mesenchymal transition, suggesting it may therapeutically inhibit metastatic biology. However, conflicting reports regarding the role of miR-200 in suppressing or promoting metastasis in different cancer types have left unanswered questions. Here we demonstrate a difference in clinical outcome based on miR-200's role in blocking tumour angiogenesis. We demonstrate that miR-200 inhibits angiogenesis through direct and indirect mechanisms by targeting interleukin-8 and CXCL1 secreted by the tumour endothelial and cancer cells. Using several experimental models, we demonstrate the therapeutic potential of miR-200 delivery in ovarian, lung, renal and basal-like breast cancers by inhibiting angiogenesis. Delivery of miR-200 members into the tumour endothelium resulted in marked reductions in metastasis and angiogenesis, and induced vascular normalization. The role of miR-200 in blocking cancer angiogenesis in a cancer-dependent context defines its utility as a potential therapeutic agent. PMID:24018975

  1. 200 000 kroonine viga Reformierakonna aruandes / Tarmo Vahter

    Index Scriptorium Estoniae

    Vahter, Tarmo, 1970-

    2008-01-01

    Reformierakonna aruande kohaselt maksis Riigikogu liige Jaanus Rahumägi 200 000 krooni reklaamfirmale Droom. J. Rahumäe väitel ei ole ta firmale maksnud sentigi. Vt. samas intervjuud Jaanus Rahumäega

  2. Color Hawaii Shaded Relief ? 200-Meter Resolution - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The NED is...

  3. 24 CFR 200.300 - Nondiscrimination and fair housing policy.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Nondiscrimination and Fair Housing... part 5; and (b) The affirmative fair housing marketing requirements in 24 CFR part 200, subpart M...

  4. NSF Obligations for Top 200 Institutions by Fiscal Year

    Data.gov (United States)

    National Science Foundation — An text/xml file containing FY 2001 through FY 2015 National Science Foundation (NSF) obligations by institution for the top 200 recipients defined in terms of total...

  5. Grayscale Hawaii Shaded Relief ? 200-Meter Resolution - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The...

  6. Color Alaska Shaded Relief ? 200-Meter Resolution - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The NED is...

  7. Grayscale Alaska Shaded Relief ? 200-Meter Resolution - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The...

  8. 1992 County Pesticide Use Estimates for 200 Compounds

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset includes information for 200 pesticides on the average amount (pounds) applied to 87 agricultural crops and the acres of crops treated for counties...

  9. Aerial Photography and Imagery, Ortho-Corrected - Osceola_200_Ortho

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Orthophotos at a map scale of 1"=200' with one foot ground pixel resolution were produced for Osceola, FL. Orthophotography was collected from DMC 10,000' above...

  10. 17 CFR 200.67 - Power to adopt rules.

    Science.gov (United States)

    2010-04-01

    ... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.67 Power to adopt rules. In exercising... rules should never tend to stifle or discourage legitimate business enterprises or activities,...

  11. 17 CFR 200.41 - Quorum of the Commission.

    Science.gov (United States)

    2010-04-01

    ...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Disposition of Commission Business § 200.41 Quorum of the... office; and provided further that on any matter of business as to which the number of members in...

  12. 49 CFR 179.200-14 - Expansion capacity.

    Science.gov (United States)

    2010-10-01

    ... determined by using formula in § 179.200-6(a). (3) The dome head, if dished, must be dished to a radius not... Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-14 Expansion capacity. (a... the tank for Class DOT-111A cars, or in a dome for Class DOT-103 and 104 type cars. (b) For tank...

  13. Characterization of Large Area APDs for the EXO-200 Detector

    Energy Technology Data Exchange (ETDEWEB)

    Neilson, R.; LePort, F.; Pocar, A.; /Stanford U., Phys. Dept.; Kumar, K.; /Massachusetts U., Amherst; Odian, A.; Prescott, C.Y.; /SLAC; Tenev, V.; /Stanford U., Phys. Dept.; Ackerman, N.; /SLAC; Akimov, D.; /Moscow, ITEP; Auger, M.; /Bern U., LHEP; Benitez-Medina, C.; /Colorado State U.; Breidenbach, M.; /SLAC; Burenkov, A.; /Moscow, ITEP; Conley, R.; /SLAC; Cook, S.; /Colorado State U.; deVoe, R.; Dolinski, M.J.; /Stanford U., Phys. Dept.; Fairbank, W., Jr.; /Colorado State U.; Farine, J.; /Laurentian U.; Fierlinger, P.; Flatt, B.; /Stanford U., Phys. Dept. /Bern U., LHEP /Stanford U., Phys. Dept. /Maryland U. /Colorado State U. /Laurentian U. /Carleton U. /SLAC /Maryland U. /Moscow, ITEP /Alabama U. /SLAC /Colorado State U. /Stanford U., Phys. Dept. /Alabama U. /Stanford U., Phys. Dept. /Alabama U. /SLAC /Carleton U. /SLAC /Maryland U. /Moscow, ITEP /Carleton U. /Stanford U., Phys. Dept. /Bern U., LHEP /SLAC /Laurentian U. /SLAC /Maryland U.

    2011-12-02

    EXO-200 uses 468 large area avalanche photodiodes (LAAPDs) for detection of scintillation light in an ultra-low-background liquid xenon (LXe) detector. We describe initial measurements of dark noise, gain and response to xenon scintillation light of LAAPDs at temperatures from room temperature to 169 K - the temperature of liquid xenon. We also describe the individual characterization of more than 800 LAAPDs for selective installation in the EXO-200 detector.

  14. The functionality of canoeists specializing in competitive distance 200 meters.

    Directory of Open Access Journals (Sweden)

    Guo Penchen

    2011-09-01

    Full Text Available The article shows the importance of reactive properties to realize the potential of canoeist of south-east Asia specializing in the 200 meters established on a specialized focus of the training process sprinter. The parameters of functionality of athletes based on integrated aerobic and anaerobic ensure competitive distance of 200 m. They are based on assessing level of aerobic power and capacity of energy supply and properties of the cardiorespiratory system in actively increasing metabolic acidosis.

  15. Characterization of large area APDs for the EXO-200 detector

    CERN Document Server

    Neilson, R; Pocar, A; Kumar, K; Odian, A; Prescott, C Y; Tenev, V; Ackerman, N; Akimov, D; Auger, M; Benitez-Medina, C; Breidenbach, M; Burenkov, A; Conley, R; Cook, S; deVoe, R; Dolinski, M J; Fairbank, W; Farine, J; Fierlinger, P; Flatt, B; Gornea, R; Gratta, G; Green, M; Hall, C; Hall, K; Hallman, D; Hargrove, C; Herrin, S; Hodgson, J; Kaufman, L J; Kovalenko, A; Leonard, D S; Mackay, D; Mong, B; Diez, M Montero; Niner, E; O'Sullivan, K; Piepke, A; Rowson, P C; Sinclair, D; Skarpaas, K; Slutsky, S; Stekhanov, V; Strickland, V; Twelker, K; Vuilleumier, J -L; Wamba, K; Wichoski, U; Wodin, J; Yang, L; Yen, Y -R

    2009-01-01

    EXO-200 uses 468 large area avalanche photodiodes (LAAPDs) for detection of scintillation light in an ultra-low-background liquid xenon (LXe) detector. We describe initial measurements of dark noise, gain and response to xenon scintillation light of LAAPDs at temperatures from room temperature to 169K - the temperature of liquid xenon. We also describe the individual characterization of more than 800 LAAPDs for selective installation in the EXO-200 detector.

  16. Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle.

    Directory of Open Access Journals (Sweden)

    Siddappa N Byrareddy

    Full Text Available Lectin-like molecules and their receptors are cell surface molecules that have been shown to play a role in either facilitating infection or serving as transporters of HIV/SIV in vivo. The role of these lectin-like molecules in the pathogenesis of HIV/SIV infection continues to be defined. In efforts to gain further insight on the potential role of these lectin-like molecules, our laboratory generated monoclonal antibodies (mAb against the human analogs of rhesus macaque CD200, CD200R and Mincle, since the rhesus macaques are accepted as the most reliable animal model to study human HIV infection. The characterization of the cell lineages from the blood and various tissues of rhesus macaques that express these lectin-like molecules are described herein. Among the mononuclear cells, the cells of the myeloid lineage of rhesus macaques are the predominant cell lineages that express readily detectable levels of CD200, CD200R and Mincle that is similar to the expression of Siglec-1 and Siglec-3 reported by our laboratory earlier. Subset analysis revealed that a higher frequency of the CD14+/CD16- subset from normal rhesus macaques express CD200, CD200R and Mincle. Differences in the frequencies and density of expression of these molecules by the gated population of CD14+ cells from various tissues are noted with PBMC and bone marrow expressing the highest and the mononuclear cells isolated from the colon and ileum expressing the lowest levels. While a significant frequency of pDCs and mDCs express Siglec-1/Siglec-3, a much lower frequency expresses CD200, CD200R and Mincle in PBMCs from rhesus macaques. The mAb against CD200 and CD200R but not Mincle appear to inhibit the infection of macrophage tropic SIV/SHIV in vitro. We conclude that these mAbs may have potential to be used as adjunctive therapeutic agents to control/inhibit SIV/HIV infection.

  17. 75 FR 31282 - Airworthiness Directives; Airbus Model A319-100, A320-200, A321-100, and A321-200 Series Airplanes

    Science.gov (United States)

    2010-06-03

    ...-100, A320-200, A321- 100, and A321-200 Series Airplanes AGENCY: Federal Aviation Administration (FAA... May 12, 2006. The error resulted in an incorrect component maintenance manual number. This AD applies to certain Airbus Model A319-100, A320-200, A321-100, and A321-200 series airplanes. This AD...

  18. Language Arts Lingo: Glossaries and Flashcards for 200+ Terms.

    Science.gov (United States)

    Blount, R. Howard, Jr.

    Intended for teachers of grades 4-8, this book provides tools and resources to help students fall in love with literature. The book contains reproducible glossaries containing over 200 literary, genre, book content, and book construction terms, along with removable flashcards, to make reviewing language arts essentials easy, enjoyable, and fun.…

  19. 17 CFR 200.610 - Self-evaluation.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Self-evaluation. 200.610... handicaps or organizations representing individuals with handicaps, to participate in the self-evaluation... following completion of the self-evaluation, maintain on file and make available for public inspection:...

  20. 24 CFR 200.625 - Affirmative fair housing marketing plan.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.625 Affirmative fair housing marketing plan. Each applicant for participation in FHA housing... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Affirmative fair housing...

  1. Analysis of Numerical Simulation Results of LIPS-200 Lifetime Experiments

    Science.gov (United States)

    Chen, Juanjuan; Zhang, Tianping; Geng, Hai; Jia, Yanhui; Meng, Wei; Wu, Xianming; Sun, Anbang

    2016-06-01

    Accelerator grid structural and electron backstreaming failures are the most important factors affecting the ion thruster's lifetime. During the thruster's operation, Charge Exchange Xenon (CEX) ions are generated from collisions between plasma and neutral atoms. Those CEX ions grid's barrel and wall frequently, which cause the failures of the grid system. In order to validate whether the 20 cm Lanzhou Ion Propulsion System (LIPS-200) satisfies China's communication satellite platform's application requirement for North-South Station Keeping (NSSK), this study analyzed the measured depth of the pit/groove on the accelerator grid's wall and aperture diameter's variation and estimated the operating lifetime of the ion thruster. Different from the previous method, in this paper, the experimental results after the 5500 h of accumulated operation of the LIPS-200 ion thruster are presented firstly. Then, based on these results, theoretical analysis and numerical calculations were firstly performed to predict the on-orbit lifetime of LIPS-200. The results obtained were more accurate to calculate the reliability and analyze the failure modes of the ion thruster. The results indicated that the predicted lifetime of LIPS-200's was about 13218.1 h which could satisfy the required lifetime requirement of 11000 h very well.

  2. 45 CFR 2541.200 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Standards for financial management systems. 2541... STATE AND LOCAL GOVERNMENTS Post-Award Requirements § 2541.200 Standards for financial management... violation of the restrictions and prohibitions of applicable statutes. (b) The financial management...

  3. Measurement Technology on 200 Liters Barrels of Radioactive Waste

    Institute of Scientific and Technical Information of China (English)

    BAI; Lei; SHAO; Jie-wen; LIU; Da-ming; LIU; Hong-bin; CHENG; Yi-mei; HE; Li-xia; ZHU; Li-qun

    2012-01-01

    <正>The measurement device on 200 liters barrel of radioactive waste is designed following the rule of orderly measurement automatically, by using the technology of non-destructive to measure the mass of radioactive waste produced from fuel cycle. Device objects as shown in Fig. 1, which consists of the

  4. 24 CFR 291.200 - Future REO acquisition method.

    Science.gov (United States)

    2010-04-01

    ... business with HUD under 2 CFR part 2424. ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Future REO acquisition method. 291... Sales Procedures § 291.200 Future REO acquisition method. (a) Under this method of property...

  5. 34 CFR 200.59 - Duties of paraprofessionals.

    Science.gov (United States)

    2010-07-01

    ... a teacher. (2) Assisting in classroom management. (3) Assisting in computer instruction. (4... direct supervision of a teacher who meets the requirements in § 200.56. (2) A paraprofessional works... the paraprofessional is working; and (iii) The paraprofessional works in close and frequent...

  6. 19 CFR 200.735-111 - Gambling, betting, and lotteries.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Gambling, betting, and lotteries. 200.735-111...-111 Gambling, betting, and lotteries. An employee shall not participate, while on Government-owned or... a gambling device, in conducting a lottery or pool, in a game for money or property, or in...

  7. 17 CFR 200.14 - Office of Administrative Law Judges.

    Science.gov (United States)

    2010-04-01

    ... Organization § 200.14 Office of Administrative Law Judges. (a) Under the Administrative Procedure Act (5 U.S.C. 551-559) and the federal securities laws, the Office of Administrative Law Judges conducts hearings in proceedings instituted by the Commission. The Administrative Law Judges are responsible for the fair...

  8. 40 CFR 156.200 - Scope and applicability.

    Science.gov (United States)

    2010-07-01

    ... Section 156.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... 170 of this chapter. The requirements addressed in these statements are designed to reduce the risk of... used in the production of agricultural plants on agricultural establishments as defined in § 170.3...

  9. Valitsus toetas Lennart Meri hooldust 200 000 krooniga

    Index Scriptorium Estoniae

    2006-01-01

    Ilmunud ka: Postimees : na russkom jazõke 30. jaan. lk. 2. Valitsus eraldas raske haigusega võitleva president Lennart Meri möödunudaastase koduhoolduse eest tasumiseks 200 000 krooni, põhjendades rahaeraldust sooviga toetada maksimaalselt presidendi ravi ja hooldamist

  10. 21 CFR 11.200 - Electronic signature components and controls.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Electronic signature components and controls. 11... SERVICES GENERAL ELECTRONIC RECORDS; ELECTRONIC SIGNATURES Electronic Signatures § 11.200 Electronic signature components and controls. (a) Electronic signatures that are not based upon biometrics shall:...

  11. Pulsar polarisation below 200 MHz: Average profiles and propagation effects

    NARCIS (Netherlands)

    Noutsos, A.; Sobey, C.; Kondratiev, V.I.; Weltevrede, P.; Verbiest, J.P.W.; Karastergiou, A.; Kramer, M.; Kuniyoshi, M.; Alexov, A.; Breton, R.P.; Bilous, A.V.; Cooper, S.; Falcke, H.; Grießmeier, J.M.; Hassall, T.E.; Hessels, J.W.T.; Keane, E.F.; Osłowski, S.; Pilia, M.; Serylak, M.; Stappers, B.W.; ter Veen, S.; van Leeuwen, J.; Zagkouris, K.; Anderson, K.; Bähren, L.; Bell, M.; Broderick, J.; Carbone, D.; Cendes, Y.; Coenen, T.; Corbel, S.; Eislöffel, J.; Fender, R.; Garsden, H.; Jonker, P.; Law, C.; Markoff, S.; Masters, J.; Miller-Jones, J.; Molenaar, G.; Osten, R.; Pietka, M.; Rol, E.; Rowlinson, A.; Scheers, B.; Spreeuw, H.; Staley, T.; Stewart, A.; Swinbank, J.; Wijers, R.; Wijnands, R.; Wise, M.; Zarka, P.; van der Horst, A.

    2015-01-01

    Aims. We present the highest-quality polarisation profiles to date of 16 non-recycled pulsars and four millisecond pulsars, observed below 200 MHz with the LOFAR high-band antennas. Based on the observed profiles, we perform an initial investigation of expected observational effects resulting from t

  12. 17 CFR 200.15 - Office of International Affairs.

    Science.gov (United States)

    2010-04-01

    ... to international securities markets. OIA facilitates the development of and, where appropriate... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Office of International... Organization § 200.15 Office of International Affairs. (a) The Office of International Affairs (“OIA”)...

  13. 7 CFR 1160.200 - Establishment and membership.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE FLUID MILK PROMOTION PROGRAM Fluid Milk Promotion Order National Fluid Milk Processor Promotion Board § 1160.200 Establishment and membership. (a)...

  14. Russia to invest 200 million Swiss Francs in international accelerator

    CERN Multimedia

    2001-01-01

    Russia will invest 200 million CHF in the LHC project, according to first deputy industry, science and technologies minister. The results of scientific research in the center will be use in various industries, enabling new Russian technologies to enter the world market.

  15. Fission barrier heights in the A ∼ 200 mass region

    Indian Academy of Sciences (India)

    K Mahata

    2015-08-01

    Statistical model analysis is carried out for - and -induced fission reactions using a consistent description for fission barrier and level density in A ∼ 200 mass region. A continuous damping of shell correction with excitation energy is considered. Extracted fission barriers agree well with the recent microscopic–macroscopic model. The shell corrections at the saddle point were found to be insignificant.

  16. 17 CFR 200.23a - Office of Economic Analysis.

    Science.gov (United States)

    2010-04-01

    ... Office also assists the Commission's enforcement effort by applying economic analysis and statistical... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Office of Economic Analysis... Organization § 200.23a Office of Economic Analysis. The Office of Economic Analysis is responsible...

  17. 34 CFR 200.51 - Notice of SEA action.

    Science.gov (United States)

    2010-07-01

    ... Programs Operated by Local Educational Agencies Lea and School Improvement § 200.51 Notice of SEA action... parents— (A) In an understandable and uniform format, including alternative formats upon request; and (B... information to the parents of each student enrolled in a school served by the LEA— (i) Directly, through...

  18. High efficiency 200 TEU container ship developed by CSC

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ After three years operation, the large, energy-efficient, environment-friendly 200 TEU container ship Changjiang developed by China Changjiang National Shipping Group Corporation (CSC) has become an important force in the fleet of container ships in the upper reaches of the Yangtze River in China.

  19. 40 CFR 61.200 - Designation of facilities.

    Science.gov (United States)

    2010-07-01

    ... Emissions From Phosphogypsum Stacks § 61.200 Designation of facilities. The provisions of this subpart apply to each owner or operator of a phosphogypsum stack, and to each person who owns, sells, distributes, or otherwise uses any quantity of phosphogypsum which is produced as a result of wet acid...

  20. Pulsar polarisation below 200 MHz: Average profiles and propagation effects

    NARCIS (Netherlands)

    Noutsos, A.; Sobey, C.; Kondratiev, V.I.; Weltevrede, P.; Verbiest, J.P.W.; Karastergiou, A.; Kramer, M.; Kuniyoshi, M.; Alexov, A.; Breton, R.P.; Bilous, A.V.; Cooper, S.; Falcke, H.; Griessmeier, J.-M.; Hassall, T.E.; Hessels, J.W.T.; Keane, E.F.; Oslowski, S.; Pilia, M.; Serylak, M.; Stappers, B.W.; Veen, S. ter; Leeuwen, J. van; Zagkouris, K.; Anderson, K.; Baehren, L.; Bell, M.E.; Broderick, J.; Carbone, D.; Cendes, Y.; Coenen, T.; Corbel, S.; Eisloeffel, J.; Fender, R.P.; Garsden, H.; Jonker, P.; Law, C.J.; Markoff, S.; Masters, J.; Miller-Jones, J.C.A.; Molenaar, G.; Osten, R.; Pietka, M.; Rol, E.; Rowlinson, A.; Scheers, L.H.A.; Spreeuw, H.; Staley, T.; Stewart, A.; Swinbank, J.; Wijers, R.A.M.J.; Wijnands, R.; Wise, M.W.; Zarka, P.; Horst, A. van der

    2015-01-01

    Aims: We present the highest-quality polarisation profiles to date of 16 non-recycled pulsars and four millisecond pulsars, observed below 200 MHz with the LOFAR high-band antennas. Based on the observed profiles, we perform an initial investigation of expected observational effects resulting from t

  1. Performance Measurements and Technology Demonstration of the VASIMR® VX-200

    Science.gov (United States)

    Longmier, B. W.; Bering, E. A.; Squire, J. P.; Glover, T. W.; Cassady, L. D.; Ilin, A. V.; Carter, M. D.; Olsen, C. S.; McCaskill, G. E.; Chang Díaz, F.

    2010-12-01

    Recent progress is discussed in the development of an advanced RF electric propulsion engine: the VAriable Specific Impulse Magnetoplasma Rocket (VASIMR®) VX-200, a 200 kW flight-technology prototype. This device is the only known industrial application of the physics of the aurora borealis. Results are presented from first stage only and first stage with booster stage experiments that were performed on the VX-200 using between 60 mg/s and 150 mg/s argon propellant. The plasma source is a helicon discharge that uses whistler mode waves near the lower hybrid frequency. The booster stage uses electromagnetic ion cyclotron wave absorption to accelerate the ions. Measurements of ion flux, ion energy, plasma density and potential gradients, and force density profiles taken in the exhaust plume of the VX-200 are made within a 150 cubic meter vacuum chamber and are presented in the context of individual stage and total engine performance. Measurements include detailed pitch angle scans of the accelerated ions and plasma parameter maps of the exhaust plume. An emphasis will be given to our ability to probe wave-particle interactions in the exhaust plume. We are now in a position to conduct more detailed auroral simulation studies and are actively seeking collaborators.

  2. CCNA routing and switching study guide exams 100-101, 200-101, and 200-120

    CERN Document Server

    Lammle, Todd

    2013-01-01

    Prepare for the new CCNA exams with this Todd Lammle study guide Cisco author, speaker, and trainer Todd Lammle is considered the authority on all things networking, and his books have sold almost a million copies worldwide. This all-purpose CCNA study guide methodically covers all the objectives of the ICND1 (100-101) and ICND2 (200-101) exams as well as providing additional insight for those taking CCNA Composite (200-120) exam. It thoroughly examines operation of IP data networks, LAN switching technologies, IP addressing (IPv4/IPv6), IP routing technologies, IP services, network device s

  3. CCNA routing and switching review guide exams 100-101, 200-101, and 200-120

    CERN Document Server

    Lammle, Todd

    2013-01-01

    Todd Lammle's focused, concise review guide, updated for the latest CCNA exams CCNA is one of the most sought after certifications for IT professionals. If you're preparing for the CCNA Routing and Switching certification, this Sybex review guide offers the best quick review available. Organized by exam objective, it's the perfect supplement to other learning tools, including the Sybex CCNA Routing and Switching Study Guide (ISBN: 9781118749616). All exam topics from exams 100-101, 200-101, and 200-120 are thoroughly covered, and additional study materials including bonus exams, electronic f

  4. [CD200 protein, bad prognostic in patients with multiple myeloma].

    Science.gov (United States)

    Vela-Ojeda, Jorge; García-Ruiz Esparza, M A; Padilla-González, Y; Pérez-Retiguin, F; Reyes-Maldonado, E; Maillet, D; Montiel-Cervantes, L A

    2015-01-01

    Introducción: el mieloma múltiple (MM) es una gammopatía monoclonal caracterizada por la proliferación anormal de células plasmáticas malignas. La proteína CD200 se ha descrito como una proteína con funciones inmunosupresoras y que es un factor de mal pronóstico en algunas enfermedades malignas, incluyendo al MM. El objetivo de este artículo es determinar la cantidad de proteína CD200 en células plasmáticas de pacientes con MM de reciente diagnóstico y en linfocitos CD3+ de donadores sanos. Métodos: se estudiaron 35 pacientes con diagnóstico reciente de MM y 25 individuos sanos. Se usaron los anticuerpos monoclonales para CD38 (PeCyC5), CD138 (APC), y CD200 (PE). El análisis estadístico fue realizado con el programa SPSS 19v. Se utilizaron las pruebas estadísticas U de Mann Whitney, curvas de supervivencia de Kaplan y Meier y la prueba de log-rank. Resultados: las frecuencias de anemia, hipercalcemia, elevación de DHL, creatinina sérica y beta-2 microglobulina fueron de 68%, 34%, 20%, 22% y 45% respectivamente. El tratamiento administrado fue MPT 20, Tal-Dex 8, y VAD 7. Cinco pacientes lograron respuesta completa, 17 respuesta parcial, y 13 respuesta menor o falla al tratamiento. Conclusiones: el CD200 es un factor de mal pronóstico para supervivencia global en pacientes con mieloma múltiple. Los linfocitos CD3+ de medula ósea de pacientes con MM expresan en mayor proporción CD200 en comparación con sujetos sanos.

  5. Feasibility study report for the 200-BP-1 operable unit

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This feasibility study examines a range of alternatives and provides recommendations for selecting a preferred alternative for remediating contamination at the 200-BP-1 operable unit. The 200-BP-1 operable unit is located in the center of the Hanford Site along the northern boundary of the 200 East Area. The 241-BY Tank Farm is located immediately to the south of the operable unit. 200-BP-1 is a source operable unit with contaminated soils associated primarily with nine inactive cribs (known as the 216-B cribs). These cribs were used for disposal of low-level radioactive liquid waste from U Plant uranium recovery operations, and waste storage tank condensate from the adjacent 241-BY Tank Farm. The cribs used for disposal of U Plant waste were in operation from 1955--1965, and the cribs used for disposal of tank condensate were in operation from 1965--1975. In addition to the cribs, four unplanned releases of radioactive materials have occurred within the operable unit. Contaminated surface soils associated with the unplanned releases have been consolidated over the cribs and covered with clean soil to reduce contaminant migration and exposure. Discharge of wastes to the cribs has resulted in soil and groundwater contamination. The groundwater is being addressed as part of the 200 East Aggregate Area, groundwater operable unit. Contaminated soils at the site can be categorized by the types of contaminants, their distribution in the soil column, and the risk posed by the various potential exposure pathways. Below the clean soil cover, the near surface soils contain low-levels of contamination with cesium-137, radium-226, strontium-90, thorium-228, and uranium. The lifetime incremental cancer risk associated with these soils if they were exposed at the surface is 9{times}10{sup {minus}5}.

  6. Pathogenicity of autoantibodies in anti-p200 pemphigoid.

    Directory of Open Access Journals (Sweden)

    Katerina Vafia

    Full Text Available Recently, the C-terminus of laminin γ1 has been identified as target antigen in anti-p200 pemphigoid and the disease was renamed as anti-laminin γ1 pemphigoid. However, the pathogenic relevance of these autoantibodies has not yet been demonstrated. Therefore, we employed an ex vivo model of autoantibody-mediated leukocyte-dependent neutrophil activation and dermal-epidermal separation (DES using cryosections of human skin. We showed that anti-p200 pemphigoid sera (n = 7 induced DES in a time-dependent manner, in contrast to sera from healthy controls. Furthermore, laminin γ1-specific IgG and serum depleted from anti-laminin γ1 reactivity were generated using the recombinant C-terminus of laminin γ1 (LAMC1-term; amino acids 1364 to 1609. Interestingly, both fractions labeled the dermal-epidermal-junction (DEJ by indirect immunofluorescence microscopy on human foreskin and recognized a 200 kDa protein by immunoblotting with dermal extract. Human and rabbit IgG against LAMC1-cterm failed to attract neutrophils at the DEJ and to induce DES. In contrast, patient serum depleted from LAMC1-cterm reactivity led to the same extent of DES as non-depleted IgG. Repeated injection of rabbit anti-murine LAMC1-cterm IgG into both neonatal and adult C57BL/6mice as well as repetitive immunization of various mouse strains with murine LAMC1-cterm failed to induce macro- and microscopic lesions. In all mice, circulating anti-LAMC1-cterm antibodies were present, but only in some mice, IgG deposits were seen at the DEJ. We conclude that autoantibodies in anti-p200 pemphigoid sera are pathogenic while pathogenicity is not mediated by autoantibodies against laminin γ1. Further studies are needed to identify the pathogenically relevant autoantigen in anti-p200 pemphigoid.

  7. Introducing HiggsBounds 2.0.0

    Energy Technology Data Exchange (ETDEWEB)

    Bechtle, Philip; Weiglein, Georg [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Brein, Oliver [Freiburg Univ. (Germany). Physikalisches Inst.; Heinemeyer, Sven [Instituto de Fisica de Cantabria (CSIC-UC), Santander (Spain); Williams, Karina [Bonn Univ. (Germany). Bethe Center for Theoretical Physics

    2011-01-15

    We introduce version 2.0.0 of the computer program HiggsBounds. The program tests neutral and charged Higgs sectors of arbitrary models against the current exclusion bounds from LEP and the Tevatron. As input, it requires a selection of model predictions, such as Higgs masses, branching ratios, effective couplings and total decay widths. The program uses the expected and observed topological cross section limits from the Higgs searches to determine whether a given parameter scenario of a model is excluded at the 95% C.L. by those searches. Version 2.0.0 includes 39/53 LEP/Tevatron Higgs search analyses, compared to 13/36 in the previous release (1.2.0). Among the newly included analyses are LEP searches for neutral Higgs bosons (H) decaying invisibly or into hadrons, LEP searches via the production modes {tau}{sup +}{tau}{sup -}H and b anti bH, Tevatron searches via t anti tH, and LEP and Tevatron searches for charged Higgs bosons. Also, all Tevatron results presented at the ICHEP'10 are included in version 2.0.0. In this note, we explain the basic ideas behind the implementation of HiggsBounds and provide a list of search topologies implemented in version 2.0.0. Furthermore, we apply HiggsBounds 2.0.0 to (a) determine the allowed Higgs mass range for a simple 4th generation model, (b) update/reproduce LEP/Tevatron Higgs exclusion plots for the MSSM m{sub h}{sup max} benchmark scenario, and (c) show exclusion results for the scalar sector of the Randall-Sundrum model. (orig.)

  8. Continuing the Operation of EXO-200 at WIPP

    Energy Technology Data Exchange (ETDEWEB)

    Gratta, Giorgio [Stanford Univ., CA (United States)

    2016-02-24

    This grant supported, in part, the operations of the EXO-200 double beta decay experiment at the Waste Isolation Pilot Plant (WIPP) for the period May 1, 2013 to Sept 30, 2015. In this period EXO-200 completed its first phase of data taking, although its operation was disrupted in Feb 2014 by the accidents at WIPP (unrelated to the experiment). The primary goal of the experiment is to search for the very rate (and to date not observed) neutrino-less double beta decay. Such decay, if observed, would shed the light of the quantum-mechanical structure of neutrinos, and the origins of elementary particle masses. Another goal of the detector is to serve as prototype of a larger neutrino-less double beta decay experiment, currently being considered by DOE-OS.

  9. Fact Sheet for KM200 Front-end Electronics

    Energy Technology Data Exchange (ETDEWEB)

    Ianakiev, Kiril Dimitrov [Los Alamos National Laboratory; Iliev, Metodi [Los Alamos National Laboratory; Swinhoe, Martyn Thomas [Los Alamos National Laboratory

    2015-07-08

    The KM200 device is a versatile, configurable front-end electronics boards that can be used as a functional replacement for Canberra’s JAB-01 boards based on the Amptek A-111 hybrid chip, which continues to be the preferred choice of electronics for large number of the boards in junction boxes of multiplicity counters that process the signal from an array of 3He detectors. Unlike the A-111 chip’s fixed time constants and sensitivity range, the shaping time and sensitivity of the new KM200 can be optimized for demanding applications such as spent fuel, and thus could improve the safeguards measurements of existing systems where the A-111 or PDT electronics does not perform well.

  10. Eddy current characterization of magnetic treatment of nickel 200

    Science.gov (United States)

    Chern, E. J.

    1993-01-01

    Eddy current methods have been applied to characterize the effect of magnetic treatments on component service-life extension. Coil impedance measurements were acquired and analyzed on nickel 200 specimens that have been subjected to many mechanical and magnetic engineering processes: annealing, applied strain, magnetic field, shot peening, and magnetic field after peening. Experimental results have demonstrated a functional relationship between coil impedance, resistance and reactance, and specimens subjected to various engineering processes. It has shown that magnetic treatment does induce changes in electromagnetic properties of nickel 200 that then exhibit evidence of stress relief. However, further fundamental studies are necessary for a thorough understanding of the exact mechanism of the magnetic field processing effect on machine-tool service life.

  11. Stabilization of 200-atom platinum nanoparticles by organosilane fragments

    KAUST Repository

    Pelzer, Katrin

    2011-04-19

    Three\\'s a charm: Platinum nanoparticles of 2 nm diameter and containing approximately 200 atoms covered with n-octylsilyl groups (see picture, right; Pt blue, Si red, C gray, H turquoise) form when [Pt(dba)2] (dba=dibenzylideneacetone) decomposes in the presence of n-octylsilane. The particles adopt a cuboctahedral structure with an edge length of three atoms. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Condensation pool experiments with steam using DN200 blowdown pipe

    Energy Technology Data Exchange (ETDEWEB)

    Laine, J.; Puustinen, M. [Lappeenranta Univ. of Technology (Finland)

    2005-08-01

    This report summarizes the results of the condensation pool experiments with steam using a DN200 blowdown pipe. Altogether five experiment series, each consisting of several steam blows, were carried out in December 2004 with a scaled-down test facility designed and constructed at Lappeenranta University of Technology. The main purpose of the experiments was to increase the understanding of different phenomena in the condensation pool during steam discharge. (au)

  13. Fission fragment mass distributions in reactions populating 200Pb

    CERN Document Server

    Chaudhuri, A; Ghosh, T K; Banerjee, K; Sadhukhan, Jhilam; Bhattacharya, S; Roy, P; Roy, T; Bhattacharya, C; Asgar, Md A; Dey, A; Kundu, S; Manna, S; Meena, J K; Mukherjee, G; Pandey, R; Rana, T K; Srivastava, V; Dubey, R; Kaur, Gurpreet; Saneesh, N; Sugathan, P; Bhattacharya, P

    2016-01-01

    The fission fragment mass distributions have been measured in the reactions 16O + 184W and 19F+ 181Ta populating the same compound nucleus 200Pb? at similar excitation energies. It is found that the widths of the mass distribution increases monotonically with excitation energy, indicating the absence of quasi-fission for both reactions. This is contrary to two recent claims of the presence of quasi-fission in the above mentioned reactions.

  14. A Simple Ocean Bottom Hydrophone with 200 Megabyte Data Capacity

    Science.gov (United States)

    1993-06-01

    single board computer (modified) Recorder 200 megabyte Winchester disk (by Conner Peripherals, part of the Onset Tattletale) Data format each one megabyte...system consists of this improved front-end with the addition of a commercially available single board computer -. a Tattletale model 6 from Onset...bit digitizer and recorder are part of the single board computer . The timing is performed by the computer and an external oscillator. 5 Figure 4: The

  15. Spectra of Highly Ionized Sulfur below 200 (A)

    Institute of Scientific and Technical Information of China (English)

    YANG Zhi-Hu; WANG You-De; MA Xin-Wen; LIU Hui-Ping; SU Hong; ZHANG Yan-Ping; XIAO Guo-Qing

    2004-01-01

    @@ Spectra of carbon-, boron-, beryllium-, lithium-, helium-, and hydrogen-like sulfur ions were obtained and studied for the wavelengths below 200 A and the energy of 80 MeV by using beam-foil method. Thirty-five lines have been identified, in which 15 lines are newly accurately measured. The spectra were analysed based on the theoretical results and other experimental data.

  16. [Humalog® 200 U/ml KwikPen™].

    Science.gov (United States)

    Scheen, A J

    2015-10-01

    Insulin lispro (Humalog®) was the first short-acting insulin analogue to be indicated for the treatment of diabetes mellitus requiring insulin therapy. After subcutaneous injection, insulin lispro has a more favourable pharmacokinetics/pharmacodynamics profile than human insulin, characterized by a faster resorption and a more rapid and less prolonged glucose-lowering activity. These properties allow a better control of postprandial hyperglycaemia and a reduction of the risk of delayed hypoglycaemia, especially at night. The patient's quality of life is also improved because insulin lispro can be injected within the 15 minutes before meal and even possibly after meal when the amount of food intake is unpredictable. Already commercialized as Humalog® 100 U/ml, insulin lispro is now also available as Humalog® 200 U/ml. A pharmacokinetics/pharmacodynamics study confirmed the bioequivalence of the two formulations, based upon the analysis of both plasma free insulin concentrations and glucose infusion rates to maintain normoglycaemia. Humalog® 200 U/ml is available in a novel disposable 3 ml pen (KwikPen™), with lower glide force and injection volume; thus this new pen is more convenient for the patient compared with the current pen used to inject Humalog® 100 U/ml. The new formulation Humalog® 200 U/ml is indicated in Europe for adult patients with type 1 or type 2 diabetes who require more than 20 units of prandial insulin per day to cover their meals.

  17. Hydrogen Plasma Generation with 200 MHz RF Ion Source

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeongtae; Park, Kwangmook; Seo, Dong Hyuk; Kim, Han-Sung; Kwon, Hyeok-Jung; Cho, Yong-Sub [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    The ion source for the system is required to be rugged with 2000 hours maintenance free operation time because it is installed in the vessel filled with SF6 gas at the pressure of 10 bar. A 200 MHz RF ion source is considered as an ion source. It is a simple construction and provides long life operation. The specifications of the ion source are 5 kV extraction voltage and 1 mA beam current referenced to the proton. RF ion source has been developed and undergone a performance test. Results of the test are presented. 200 MHz RF ion source is designated and manufactured. First of all test stand test of ion source are set up for a performance test of ion source. It includes a RF ion source, a 200-MHz RF system, beam extraction system, vacuum system, beam extraction system, and beam diagnostic system. At pressure of 1.2E-5 torr, hydrogen plasma is generated with net RF power 70 W. Pyrex tube surrounded by an inductive coil takes the role of vessel and discharge is enhanced with field of permanent magnets.

  18. Visual system effects of exercise on Mauna Kea at 2,200 and 4,200 meters altitude.

    Science.gov (United States)

    Schmeisser, E T; Gagliano, D L; Santiago-Marini, J

    1997-03-01

    Field exercise studies were performed at two altitudes (2,200 and 4,200 m) in 2 successive years using different sets of young male volunteers. Visual function indices were measured both at sea level and during a strenuous exercise regime at altitude. Volunteers were grouped in the first study by initial rest period (2 days vs. no rest) and in the second by diet (supplemental carbohydrates vs. Meals Ready to Eat rations only). Overall results showed no effect according to grouping, a decrease in average visual acuity at the higher altitude overall, and a decrease in electroretinographic (ERG) photopic flicker responses at moderate altitude. It is concluded that heavy exercise at these altitudes may not have operationally significant effects on ground troops in night vision or target recognition, although the change in ERG parameters does indicate a shift in retinal cone physiology that may have subtler effects.

  19. POLYSHIFT Communications Software for the Connection Machine System CM-200

    Directory of Open Access Journals (Sweden)

    William George

    1994-01-01

    Full Text Available We describe the use and implementation of a polyshift function PSHIFT for circular shifts and end-offs shifts. Polyshift is useful in many scientific codes using regular grids, such as finite difference codes in several dimensions, and multigrid codes, molecular dynamics computations, and in lattice gauge physics computations, such as quantum chromodynamics (QCD calculations. Our implementation of the PSHIFT function on the Connection Machine systems CM-2 and CM-200 offers a speedup of up to a factor of 3–4 compared with CSHIFT when the local data motion within a node is small. The PSHIFT routine is included in the Connection Machine Scientific Software Library (CMSSL.

  20. Radiation emission from the "Rhodotron-TT200" cavity

    Institute of Scientific and Technical Information of China (English)

    Farshid Tabbakh; Mahmud Borhani

    2011-01-01

    In this paper, the X-rays emitted from the Rhodotron-TT200 cavity have been studied in depth.We found that the Bremsstrahlung interaction is the only contribution of X-ray generation important to safety.The X-ray dose rate in the Rhodotron vault is calculated for normal conditions based on MCNP4C results.The presented calculation shows good agreement with the experimental measurements, which consequently confirms the reliability of the calculation for use in shielding design and other safety aspects.

  1. Epidemiology in Ethiopia 200 years after John Snow's birth.

    Science.gov (United States)

    Enquselassie, Fikre

    2013-10-01

    The year 2013 marks exactly 200 years since John Snow, known as the father of modern epidemiology, was born. In 19th century, epidemiologists like John Snow, concentrated almost entirely upon infectious diseases of humans measuring the burden of disease, describing pattern and attempting to understand the transmission dynamics. During the second half of the 20th century; big changes occurred so that epidemiologists in the developed world started to use systematized approaches to investigate the etiologies, conditions and to evaluate interventions through different study designs. However, the situation in the developing world is not the same as the rest of the world. Even 200 years after Snow's birth, epidemiological capacity is lowest in Africa. This article attempts to describe that Ethiopia is not exceptional. In the past few decades, there have been some attempts to build capacity in the country by launching training programs in clinical epidemiology, general epidemiology and field epidemiology. However, not only few epidemiologists are trained, but, limited funding, high-teaching burdens, poor working conditions and low salaries are among important contributors for epidemiological brain drain in Ethiopia. Thus, strengthening learning opportunities and rewarding career paths are required to increase human resource capacity and retain skilled personnel in the field of epidemiology.

  2. Safety analysis, 200 Area, Savannah River Plant: Separations area operations

    Energy Technology Data Exchange (ETDEWEB)

    Perkins, W.C.; Lee, R.; Allen, P.M.; Gouge, A.P.

    1991-07-01

    The nev HB-Line, located on the fifth and sixth levels of Building 221-H, is designed to replace the aging existing HB-Line production facility. The nev HB-Line consists of three separate facilities: the Scrap Recovery Facility, the Neptunium Oxide Facility, and the Plutonium Oxide Facility. There are three separate safety analyses for the nev HB-Line, one for each of the three facilities. These are issued as supplements to the 200-Area Safety Analysis (DPSTSA-200-10). These supplements are numbered as Sup 2A, Scrap Recovery Facility, Sup 2B, Neptunium Oxide Facility, Sup 2C, Plutonium Oxide Facility. The subject of this safety analysis, the, Plutonium Oxide Facility, will convert nitrate solutions of {sup 238}Pu to plutonium oxide (PuO{sub 2}) powder. All these new facilities incorporate improvements in: (1) engineered barriers to contain contamination, (2) barriers to minimize personnel exposure to airborne contamination, (3) shielding and remote operations to decrease radiation exposure, and (4) equipment and ventilation design to provide flexibility and improved process performance.

  3. The 200 Degree-Long Magellanic Stream System

    CERN Document Server

    Nidever, David L; Burton, W Butler; Nigra, Lou

    2010-01-01

    We establish that the Magellanic Stream (MS) is some 40 degrees longer than previously known with certainty and that the entire MS and Leading Arm (LA) system is thus at least 200 degrees long. With the GBT, we conducted a ~200 square degree, 21-cm survey at the MS-tip to substantiate the continuity of the MS between the Hulsbosch & Wakker data and the MS-like emission reported by Braun & Thilker. Our survey, in combination with the Arecibo survey by Stanimirovic et al., shows that the MS gas is continuous in this region and that the MS is at least ~140 degrees long. We identify a new filament on the eastern side of the MS that significantly deviates from the equator of the MS coordinate system for more than ~45 degrees. Additionally, we find a previously unknown velocity inflection in the MS-tip near MS longitude L_MS=-120 degrees at which the velocity reaches a minimum and then starts to increase. We find that five compact high velocity clouds cataloged by de Heij et al. as well as Wright's Cloud ar...

  4. State waste discharge permit application, 200-E chemical drain field

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    As part of the Hanford Federal Facility Agreement and Consent Order negotiations (Ecology et al. 1994), the US Department of Energy, Richland Operations Office, the US Environmental Protection Agency, and the Washington State Department of Ecology agreed that liquid effluent discharges to the ground on the Hanford Site which affect groundwater or have the potential to affect ground would be subject to permitting under the structure of Chapter 173-216 (or 173-218 where applicable) of the Washington Administrative Code, the State Waste Discharge Permit Program. As a result of this decision, the Washington State Department of Ecology and the US Department of Energy, Richland Operations Office entered into Consent Order No. DE 91NM-177, (Ecology and DOE-RL 1991). The Consent Order No. DE 91NM-177 requires a series of permitting activities for liquid effluent discharges. This document presents the State Waste Discharge Permit (SWDP) application for the 200-E Chemical Drain Field. Waste water from the 272-E Building enters the process sewer line directly through a floor drain, while waste water from the 2703-E Building is collected in two floor drains, (north and south) that act as sumps and are discharged periodically. The 272-E and 2703-E Buildings constitute the only discharges to the process sewer line and the 200-E Chemical Drain Field.

  5. Inspiratory muscle training improves 100 and 200 m swimming performance.

    Science.gov (United States)

    Kilding, Andrew E; Brown, Sarah; McConnell, Alison K

    2010-02-01

    Inspiratory muscle training (IMT) has been shown to improve time trial performance in competitive athletes across a range of sports. Surprisingly, however, the effect of specific IMT on surface swimming performance remains un-investigated. Similarly, it is not known whether any ergogenic influence of IMT upon swimming performance is confined to specific race distances. To determine the influence of IMT upon swimming performance over 3 competitive distances, 16 competitive club-level swimmers were assigned at random to either an experimental (pressure threshold IMT) or sham IMT placebo control group. Participants performed a series of physiological and performance tests, before and following 6 weeks of IMT, including (1) an incremental swim test to the limit of tolerance to determine lactate, heart rate and perceived exertion responses; (2) standard measures of lung function (forced vital capacity, forced expiratory volume in 1 s, peak expiratory flow) and maximal inspiratory pressure (MIP); and (3) 100, 200 and 400 m swim time trials. Training utilised a hand-held pressure threshold device and consisted of 30 repetitions, twice per day. Relative to control, the IMT group showed the following percentage changes in swim times: 100 m, -1.70% (90% confidence limits, +/-1.4%), 200 m, -1.5% (+/-1.0), and 400 m, 0.6% (+/-1.2). Large effects were observed for MIP and rates of perceived exertion. In conclusion, 6 weeks of IMT has a small positive effect on swimming performance in club-level trained swimmers in events shorter than 400 m.

  6. 200系的科学认识和审慎使用

    Institute of Scientific and Technical Information of China (English)

    陈金虎; 李筱

    2009-01-01

    本文介绍了200系的起源和发展,以及国内的发展情况,重点阐述了标准200系和非标200系的特点以及滥用200系存在的严重后果,最后警示用户应科学认识200系并审慎使用。

  7. Survey of 200 cases of the abdominal aortography

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ki Jeung; Choi, Doo Suk; Hah, Hae Koo [National Medical Center, Seoul (Korea, Republic of)

    1972-12-15

    From 1962 to 1970 about 200 abdominal aortographies were performed in Department of Radiology of National Medical Center, Seoul, Korea, with percutaneous retrograde seldinger catheterization technique. The 200 cases of the abdominal aortography were analyzed as followings. 1) The sex ratio of all patients was 105 (52.5%) males to 95 (47.5%) females. And high incidence was noted in middle age group. (46 patients were from 30 years to 40 years of age) 2) Radiological findings were grouped as 62 (31%) vascular lesion, 113 (56.5%) visceral or other expanding lesions and 29 (14.5%) angiographically nonspecific findings. Total is over 200 due to double lesions in 4 patients. 3) The 62 vascular lesions were composed of 40 aortitis, 28 renal hypertension etc. a) The 40 aortitis was divided into 25 artherosclerotic and 15 nonspecific. The 15 nonspecific aortitis revealed segmental narrowing (2-4 cm) with collaterals. b) In 28 renal hypertension, 17 cases were combined with aortitis, but not in 11 cases (Pure renal hypertension), and 19 cases were unilateral. 4) The highest incidence in 113 (56.5%) visceral or other expanding lesions, was renal lesions (88 cases), and other lesions, such as 12 retroperitoneal masses, 9 liver and pancreatic masses were also noted. The 88 renal lesions were composed of 37 renal tbc, 17 hydronephrosis (excluding tbc hydro), Tumors, 10 cyst etc. a) The most significant findings of renal tuberculosis in renal arteriogrpahy was rarefaction of contrast staining in involved area which was noted in 32 cases (87%) out of 37 renal Tuberculosis. b) All 12 hypernephroma, 1 wilm's tumor, metastaic tumor from fibromyomata uteri revealed pathological vessels and tumor stainings, however these findings were not noted in 2 ureteral carcinoma involving renal pelvis. 5) No permanent complications arose after abdominal aortography. (Percutaneous retrograde seldinger catheterization technique) 6) Abdominal aortography and selective visceral injections gave

  8. Pulsar polarisation below 200 MHz: Average profiles and propagation effects

    CERN Document Server

    Noutsos, A; Kondratiev, V I; Weltevrede, P; Verbiest, J P W; Karastergiou, A; Kramer, M; Kuniyoshi, M; Alexov, A; Breton, R P; Bilous, A V; Cooper, S; Falcke, H; Grießmeier, J -M; Hassall, T E; Hessels, J W T; Keane, E F; Osłowski, S; Pilia, M; Serylak, M; Stappers, B W; ter Veen, S; van Leeuwen, J; Zagkouris, K; Anderson, K; Bähren, L; Bell, M; Broderick, J; Carbone, D; Cendes, Y; Coenen, T; Corbel, S; Eislöffel, J; Fender, R; Garsden, H; Jonker, P; Law, C; Marko, S; Masters, J; Miller-Jones, J; Molenaar, G; Osten, R; Pietka, M; Rol, E; Rowlinson, A; Scheers, B; Spreeuw, H; Staley, T; Stewart, A; Swinbank, J; Wijers, R; Wijnands, R; Wise, M; Zarka, P; van der Horst, A

    2015-01-01

    We present the highest-quality polarisation profiles to date of 16 non-recycled pulsars and four millisecond pulsars, observed below 200 MHz with the LOFAR high-band antennas. Based on the observed profiles, we perform an initial investigation of expected observational effects resulting from the propagation of polarised emission in the pulsar magnetosphere and the interstellar medium. The predictions of magnetospheric birefringence in pulsars have been tested using spectra of the pulse width and fractional polarisation from multifrequency data. The derived spectra offer only partial support for the expected effects of birefringence on the polarisation properties, with only about half of our sample being consistent with the model's predictions. It is noted that for some pulsars these measurements are contaminated by the effects of interstellar scattering. For a number of pulsars in our sample, we have observed significant variations in the amount of Faraday rotation as a function of pulse phase, which is possi...

  9. Hypnosis for cancer care: over 200 years young.

    Science.gov (United States)

    Montgomery, Guy H; Schnur, Julie B; Kravits, Kate

    2013-01-01

    Answer questions and earn CME/CNE Hypnosis has been used to provide psychological and physical comfort to individuals diagnosed with cancer for nearly 200 years. The goals of this review are: 1) to describe hypnosis and its components and to dispel misconceptions; 2) to provide an overview of hypnosis as a cancer prevention and control technique (covering its use in weight management, smoking cessation, as an adjunct to diagnostic and treatment procedures, survivorship, and metastatic disease); and 3) to discuss future research directions. Overall, the literature supports the benefits of hypnosis for improving quality of life during the course of cancer and its treatment. However, a great deal more work needs to be done to explore the use of hypnosis in survivorship, to understand the mediators and moderators of hypnosis interventions, and to develop effective dissemination strategies.

  10. Hydrogen permeation in stationary arc-melted nickel 200

    Science.gov (United States)

    Li, H.; North, T. H.; Sommerville, I. D.; McLean, A.

    1990-06-01

    A combination of hydrogen permeation experiments and computer simulation was used to evaluate the distributions of temperature and of the hydrogen transfer flux in a stationary arcmelted Nickel 200 disc over the entire hydrogen permeation zone. The results indicate that the markedly nonuniform temperature distribution in the hydrogen permeation zone involves widely varying hydrogen fluxes and even transfer of hydrogen in different directions. At steady state, the hydrogen distribution is determined by a thermally produced dynamic equilibrium. Hydrogen supersaturation occurs in solid nickel at the solid/liquid interface in the arc-melted pool. An increase in hydrogen partial pressure in the shielding gas increases the heat input to the melt and decreases the stability of the arc melting process.

  11. Passive neutron design study for 200-L waste drums

    Energy Technology Data Exchange (ETDEWEB)

    Menlove, H.O.; Beddingfield, D.B.; Pickrell, M.M. [and others

    1997-09-01

    We have developed a passive neutron counter for the measurement of plutonium in 200-L drums of scrap and waste. The counter incorporates high efficiency for the multiplicity counting in addition to the traditional coincidence counting. The {sup 252}Cf add-a-source feature is used to provide an accurate assay over a wide range of waste matrix materials. The room background neutron rate is reduced by using 30 cm of external polyethylene shielding and the cosmic-ray background is reduced by statistical filtering techniques. Monte Carlo Code calculations were used to determine the optimum detector design, including the gas pressure, size, number, and placement of the {sup 3}He tubes in the moderator. Various moderators, including polyethylene, plastics, teflon, and graphite, were evaluated to obtain the maximum efficiency and minimum detectable mass of plutonium.

  12. 200 more puzzling physics problems with hints and solutions

    CERN Document Server

    Gnädig, Péter; Vigh, Máté

    2016-01-01

    Like its predecessor, 200 Puzzling Physics Problems, this book is aimed at strengthening students' grasp of the laws of physics by applying them to situations that are practical, and to problems that yield more easily to intuitive insight than to brute-force methods and complex mathematics. The problems are chosen almost exclusively from classical, non-quantum physics, but are no easier for that. They are intriguingly posed in accessible non-technical language, and require readers to select an appropriate analysis framework and decide which branches of physics are involved. The general level of sophistication needed is that of the exceptional school student, the good undergraduate, or the competent graduate student; some physics professors may find some of the more difficult questions challenging. By contrast, the mathematical demands are relatively minimal, and seldom go beyond elementary calculus. This further book of physics problems is not only instructive and challenging, but also enjoyable.

  13. Results of 200 KW fuel cell evaluation programs

    Energy Technology Data Exchange (ETDEWEB)

    Torrey, J.M.; Merten, G.P. [SAIC, San Diego, CA (United States); Binder, M.J. [Army Construction Engineering Research Labs., Champaign, IL (United States)] [and others

    1996-12-31

    Science Applications International Corporation (SAIC) has installed six monitoring systems on ONSI Corporation 200 kW phosphoric acid fuel cells. Three of the systems were installed for the U.S. Army Construction Engineering Research Laboratories (USACERL) which is coordinating the Department of Defense (DoD) fuel cell Demonstration Program and three were installed under a contract with the New York State Energy Research and Development Authority (NYSERDA). Monitoring of the three NYSERDA sites has been completed. Monitoring systems for the DoD fuel cells were installed in August, 1996 and thus no operating data was available at the time of this writing, but will be presented at the Fuel Cell Seminar. This paper will present the monitoring configuration and research approach for each program. Additionally, summary performance data is presented for the completed NYSERDA program.

  14. Fall 1998 200 East area biological vector contamination report

    Energy Technology Data Exchange (ETDEWEB)

    CONNELL, D.J.

    1999-03-17

    The purpose of this report is to document the investigation into the cause of the spread of radioactive contamination in September and October 1998 at the Hanford Site's 200 East Area and its subsequent spread to the City of Richland Landfill; identify the source of the contamination; and present corrective actions. The focus and thrust of managing the incident was based on the need to accomplish the following, listed in order of importance: (1) protect the health and safety of the Site workers and the public; (2) contain and control the spread of contamination; (3) identify the source of contamination and the pathways for its spread; and (4) identify the causal factors enabling the contamination.

  15. High Reflectivity of Silver Extended Down to 200 NM

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, N L; Wolfe, J D

    2001-06-04

    Silver has the highest reflectance of all of the metals, but it tarnishes in the presence of sulfides, chlorides, and oxides in the atmosphere. Also, the silver reflectance is very low at wavelengths below 400 nm making aluminum more desirable mirror coating for the W region. We have found a way to prevent silver tarnishing by sandwiching the silver layer between two thin layers of NiCrN{sub x}, and to extend the metal's high reflectance down to 200 nm by depositing the (thin) Ag layer on top of Al. Thus, the uv is transmitted through the thin Ag layer below 400 nm wavelength, and is reflected from the A1 layer underneath. This W-shifted durable coating provides a valuable alternative to the aluminum coating for telescope mirror coatings where collection efficiency is an important consideration.

  16. In vitro evaluation of carbamazepine 200 mg tablets.

    Science.gov (United States)

    Kibwage, I O; Nguyo, M

    1993-08-01

    A comparative in-vitro performance of carbamazepine 200mg tablet products available on the Kenyan market was evaluated. The products which include the innovator product, Tegretol, have similar quality consonant with pharmacopoeial specifications. A batch of one of the products had a carbamazepine content of 106.6% label claim which was outside the upper limits of 105%. One product packaged in multiple-unit containers of a 1000, had an unacceptable high friability of 6.82% loss in weight. All products had good dissolution profiles and released at least 70% of the dose within 45 minutes. Drug dissolution from tablets was found to vary between batches for one product. At each sampling time, most generics had wide variations in amount of dissolved drug. The effect of such variations on tablet efficacy cannot be ascertained in the absence of bioavailability data.

  17. Optimization of 200 kV electrostatic accelerator

    Directory of Open Access Journals (Sweden)

    M Nazmabadi

    2015-09-01

    Full Text Available Optimizations on 200 kV electrostatic accelerator have been done in order to increasing ion current on target, improving vacuum condition and reduction in x-rays emission, increasing stability of high voltage power supply and reaching much greater achievable voltage value. The accelerator tube has most important effect on beam tracing in the electrostatic accelerators. So precautions most be considered in designing and constructing of this part. In order to finding permissible tolerances in construction and assembling of 200 kV electrostatic accelerator column, first the effects of angle deviation of a part from accelerator axis on beam track in the accelerator tube was simulated with Simion 7.0 computer program. We found that in order to prevent beam lost, the tolerances of balancing and co-centering of each part should be smaller than 0.1 mm. Each part of accelerator tube constructed by tolerances lower than 0.05 mm. Ultrasonic cleaning method used in pre-assembling process of parts. Because of its excellences, in the new tube we used borosilicate glass instead of high density alumina as insulators between the metallic electrodes. After three days of working vacuum pumps the system reached to 8.0×10-7 and after months to 5.0×10-7 ultimate pressure values. Measurements showed that by these considerations the maximum of reachable ion current on target was 1.1 mA which increased 50% compared to old machine, while x-ray emission intensity was increased by 25%. Optimizations of high voltage power supply are now under studies and tests

  18. Laparoscopic repair of hiatal hernias: Experience after 200 consecutive cases

    Directory of Open Access Journals (Sweden)

    Bjelović Miloš

    2014-01-01

    Full Text Available Introduction. Repair of hiatal hernias has been performed traditionally via open laparotomy or thoracotomy. Since first laparoscopic hiatal hernia repair in 1992, this method had a growing popularity and today it is the standard approach in experienced centers specialized for minimally invasive surgery. Objective. In the current study we present our experience after 200 consecutive laparoscopic hiatal hernia repairs. Methods. A retrospective cohort study included 200 patients who underwent elective laparoscopic hiatal hernia repair at the Department for Minimally Invasive Upper Digestive Surgery, Clinic for Digestive Surgery, Clinical Center of Serbia in Belgrade from April 2004 to December 2013. Results. Hiatal hernia types included 108 (54% patients with type I, 30 (15% with type III, 62 (31% with giant paraesophageal hernia, while 27 (13.5% patients presented with a chronic gastric volvulus. There were a total of 154 (77% Nissen fundoplications. In 26 (13% cases Nissen procedure was combined with esophageal lengthening procedure (Collis-Nissen, and in 17 (8.5% Toupet fundoplications was performed. Primary retroesophageal crural repair was performed in 164 (82% cases, Cleveland Clinic Foundation suture modification in 27 (13.5%, 4 (2% patients underwent synthetic mesh hiatoplasty, 1 (0.5% primary repair reinforced with pledgets, and 4 (2% autologous fascia lata graft reinforcement. Poor result with anatomic and symptomatic recurrence (indication for revisional surgery was detected in 5 patients (2.7%. Conclusion. Based on the result analysis, we found that laparoscopic hiatal hernia repair was a technically challenging but feasible technique, associated with good to excellent postoperative outcomes comparable to the best open surgery series.

  19. miR-200 family and gastrointestinal tumors%miR-200家族在消化系肿瘤中的研究进展

    Institute of Scientific and Technical Information of China (English)

    杜平; 张庆瑜

    2011-01-01

    The miR-200 family (including miR-200a, miR-200b, miR-200c, miR-141, and miR-429) play important roles in proliferation, invasion and metastasis of tumors of epithelial origin. Gastrointestinal tumors belong to a group of tumors of epithelial origin. This article reviews the latest advances in understanding the relationship between the miR-200 family and gastrointestinal tumors.%miR-200家族(miR-200a、miR-200b、miR-200c、miR-141、miR-429)是众多已被发现的mieroRNA中的一员,其在上皮来源肿瘤的增殖、侵袭、转移中的作用成为近年来的研究热点之一,本文对miR-200家族在同为上皮来源的消化系肿瘤中的研究进展进行了综述.

  20. Immunomodulator CD200 promotes neurotrophic activity by interacting with and activating the fibroblast growth factor receptor

    DEFF Research Database (Denmark)

    Pankratova, Stanislava; Bjornsdottir, Halla; Christensen, Claus;

    2016-01-01

    in the suppression of microglia activation. We for the first time demonstrated that CD200 can interact with and transduce signaling through activation of the fibroblast growth factor receptor (FGFR), thereby inducing neuritogenesis and promoting neuronal survival in primary neurons. CD200-induced FGFR...... phosphorylation was abrogated by CD200R, whereas FGF2-induced FGFR activation was inhibited by CD200. We also identified a sequence motif located in the first Ig-like module of CD200, likely representing the minimal CD200 binding site for FGFR. The FGFR binding motif overlaps with the CD200R binding site......, suggesting that they can compete for CD200 binding in cells that express both receptors. We propose that CD200 in neurons functions as a ligand of FGFR....

  1. Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.

    Directory of Open Access Journals (Sweden)

    Stefano Caserta

    Full Text Available Certain parasites have evolved to evade the immune response and establish chronic infections that may persist for many years. T cell responses in these conditions become muted despite ongoing infection. Upregulation of surface receptors with inhibitory properties provides an immune cell-intrinsic mechanism that, under conditions of chronic infection, regulates immune responses and limits cellular activation and associated pathology. The negative regulator, CD200 receptor, and its ligand, CD200, have been shown to regulate macrophage activation and reduce pathology following infection. We show that CD4 T cells also increase expression of inhibitory CD200 receptors (CD200R in response to chronic infection. CD200R was upregulated on murine effector T cells in response to infection with bacterial, Salmonella enterica, or helminth, Schistosoma mansoni, pathogens that respectively drive predominant Th1- or Th2-responses. In vitro chronic and prolonged stimuli were required for the sustained upregulation of CD200R, and its expression coincided with loss of multifunctional potential in T effector cells during infection. Importantly, we show an association between IL-4 production and CD200R expression on T effector cells from humans infected with Schistosoma haematobium that correlated effectively with egg burden and, thus infection intensity. Our results indicate a role of CD200R:CD200 in T cell responses to helminths which has diagnostic and prognostic relevance as a marker of infection for chronic schistosomiasis in mouse and man.

  2. DETAILED ANALYSIS OF THE MOST PROMISING ALTERNATIVES TO USING GRANULAR ACTIVATED CARBON TO TREAT 200-ZP-1 GROUNDWATER AND 200-PW-1 SOIL VAPOR

    Energy Technology Data Exchange (ETDEWEB)

    BYRNES ME, KALMAR JA

    2007-11-26

    This document presents a detailed evaluation of selected alternative treatment options to granular activated carbon (GAC) for removing carbon tetrachloride generated from the groundwater pump-and-treat system at the 200-ZP-I Operable Unit (OU) in the 200 West Area of the Hanford Site. This evaluation of alternative treatment options to GAC is also applicable to the vadose zone soil vapor extraction (SVE) system at the 200-PW-l OU, which is also located in the Hanford Site's 200 West Area.

  3. The Atacama Cosmology Telescope: CMB Polarization at $200<\\ell<9000$

    CERN Document Server

    Naess, Sigurd; McMahon, Jeff; Niemack, Michael D; Addison, Graeme E; Ade, Peter A R; Allison, Rupert; Amiri, Mandana; Baker, Andrew; Battaglia, Nick; Beall, James A; de Bernardis, Francesco; Bond, J Richard; Britton, Joe; Calabrese, Erminia; Cho, Hsiao-mei; Coughlin, Kevin; Crichton, Devin; Das, Sudeep; Datta, Rahul; Devlin, Mark J; Dicker, Simon R; Dunkley, Joanna; Dünner, Rolando; Fowler, Joseph W; Fox, Anna E; Gallardo, Patricio; Grace, Emily; Gralla, Megan; Hajian, Amir; Halpern, Mark; Henderson, Shawn; Hill, J Colin; Hilton, Gene C; Hilton, Matt; Hincks, Adam D; Hlozek, Renée; Ho, Patty; Hubmayr, Johannes; Huffenberger, Kevin M; Hughes, John P; Infante, Leopoldo; Irwin, Kent; Jackson, Rebecca; Klein, Jeff; Koopman, Brian; Kosowsky, Arthur; Li, Dale; Louis, Thibaut; Lungu, Marius; Madhavacheril, Mathew; Marriage, Tobias A; Maurin, Loïc; Menanteau, Felipe; Moodley, Kavilan; Munson, Charles; Newburgh, Laura; Nibarger, John; Nolta, Michael R; Page, Lyman A; Pappas, Christine; Partridge, Bruce; Rojas, Felipe; Schmitt, Benjamin; Sehgal, Neelima; Sherwin, Blake D; Sievers, Jon; Simon, Sara; Spergel, David N; Staggs, Suzanne T; Switzer, Eric R; Thornton, Robert; Trac, Hy; Tucker, Carole; Van Engelen, Alexander; Ward, Jon; Wollack, Edward J

    2014-01-01

    We report on measurements of the cosmic microwave background (CMB) and celestial polarization at 146 GHz made with the Atacama Cosmology Telescope Polarimeter (ACTPol) in its first three months of observing. Four regions of sky covering a total of 270 square degrees were mapped with an angular resolution of $1.3'$. The map noise levels in the four regions are between 11 and 17 $\\mu$K-arcmin. We present TT, TE, EE, TB, EB, and BB power spectra from three of these regions. The observed E-mode polarization power spectrum, displaying six acoustic peaks in the range $200<\\ell<3000$, is an excellent fit to the prediction of the best-fit cosmological models from WMAP9+ACT and Planck data. The polarization power spectrum, which mainly reflects primordial plasma velocity perturbations, provides an independent determination of cosmological parameters consistent with those based on the temperature power spectrum, which results mostly from primordial density perturbations. We find that without masking any point sou...

  4. Computerized tomographic studies in cerebral palsy. Analysis of 200 cases

    Energy Technology Data Exchange (ETDEWEB)

    Sugie, Y. (Tokyo Women' s Medical Coll. (Japan))

    1981-09-01

    Computed tomographic (CT) findings in 200 children with cerebral palsy (CP) were analysed from the viewpoint of clinical manifestations, disease complications and etiological factors. CT scans of 135 cases (67.5%) were found to be abnormal and there were 14 (7%) borderline cases. The major abnormality found on CT scans was cerebral atrophy. Other important changes included focal or diffuse low density area in the brain tissue, congenital malformation, and cerebellar atrophy. From the clinical point of view, a large number of patients with spastic tetraplegia and spastic diplegia showed highly abnormal CT scans. On the other hand, in patients with spastic monoplegia, spastic paraplegia, and athetotic type, CT findings were normal or revealed only minor cerebral atrophy. Most children showing asymmetric clinical symptoms had corresponding asymmetric CT abnormalities which included ventricular enlargement, low density area in the brain tissue, and hemispherical volume. There was a significant correlation between the severity of physical impairment and the extent of CT abnormalities. Severely affected children had grossly abnormal CT scans such as hydranencephaly, polycystic change, and extensive cerebral atrophy. In the patients complicated with epilepsy, the incidence and severity of abnormal CT were higher than those of non-epileptic patients. Mentally retarded patients had variable enlargement of the subarachnoidal space depending on the severity of their mental retardation. Patients with suspected postnatal etiology also had high incidence of severe CT abnormality. CT scan is a valuable tool for evaluating patients with CP and in some cases, possible etiology of the disease may be discovered.

  5. DC SQUID RF magnetometer with 200 MHz bandwidth

    Science.gov (United States)

    Talanov, Vladimir; Lettsome, Nesco; Orozco, Antonio; Cawthorne, Alfred; Borzenets, Valery

    2012-02-01

    Because of periodic flux-to-voltage transfer function, Superconducting QUantum Interference Device (SQUID) magnetometers operate in a closed-loop regime [1], which linearizes the response, and increases the dynamic range and sensitivity. However, a transmission line delay between the SQUID and electronics fundamentally limits the closed-loop bandwidth at 20 MHz [1], although the intrinsic bandwidth of SQUIDs is in gigahertz range. We designed a DC SQUID based RF magnetometer capable of wideband sensing coherent magnetic fields up to 200 MHz. To overcome the closed-loop bandwidth limitation, we utilized a low-frequency flux-modulated closed-loop to simultaneously lock the quasi-static magnetic flux and provide AC bias for the RF flux. The SQUID RF voltage is processed by RF electronics based on a double lock-in technique. This yields a signal proportional to the amplitude and phase of the RF magnetic flux, with more than four decades of a linear response. For YBaCuO SQUID on bi-crystal SrTiO substrate at 77 K we achieved a flux noise density of 4 μφ0/Hz at 190 MHz, which is similar to that measured at kHz frequencies with conventional flux-locked loop. [1] D. Drung, et al., Supercond. Sci. Technol. 19, S235 (2006).

  6. A 200-GHz telescope unit for the QUIJOTE CMB Experiment

    Science.gov (United States)

    Sanquirce, Rubén.; Etxeita, Borja; Murga, Gaizka; Fernandez, Esther; Sainz, Iñaki; Sánchez, Vicente; Viera-Curbelo, Teodora A.; Gómez, María. F.; Aguiar-Gonzalez, Marta; Hoyland, Roger J.; Pérez de Taoro, Ángeles R.; Vega, Afrodisio; Rebolo-López, Rafael; Rubiño, Jose Alberto

    2014-07-01

    Experiment QUIJOTE (Q-U-I JOint TEnerife) is a scientific collaboration, leaded by the Instituto de Astrofísica de Canarias (IAC), which can measure the polarization of the Cosmic Microwave Background (CMB) in the range of frequency up to 200 GHz, at angular scales of 1°. The project is composed of 2 telescopes and 3 instruments, located in Teide Observatory (Tenerife, Spain). After the successful delivery of the first telescope (operative since 2012), Idom is currently involved on the turn key supply of the second telescope (phase II). The work started in June 2013 and it will be completed in a challenging period of 12 months (operative at the beginning of July 2014), including design, factory assembly and testing, transport and final commissioning on site. This second unit will improve the opto-mechanical performance and maintainability. The telescope will have an unlimited rotation capacity in azimuth axis and a range of movement between 25°-95° in elevation axis. An integrated rotary joint will transmit fluid, power and signal to the rotary elements. The pointing and tracking accuracy will be significantly below to specification: 1.76 arcmin and 44 arcsec, respectively. This project completes Idoḿs contribution during phase I, which also comprises the integration and functional tests for the 5 polarimeters of the first instrument in Bilbao headquarters, and the design and supervision of the building which protects both telescopes, including the installation and commissioning of the mechanism for shutters aperture.

  7. [Clinical analysis of 200 cases of idiopathic thrombocytopenic purpura].

    Science.gov (United States)

    García-Stivalet, Lilia Adela; Muñoz-Flores, Aarón; Montiel-Jarquín, Alvaro José; Barragán-Hervella, Rodolfo Gregorio; Bejarano-Huertas, Ruth; García-Carrasco, Mario; López-Colombo, Aurelio

    2014-01-01

    INTRODUCCIÓN: la púrpura trombocitopénica idiopática se caracteriza por la extravasación de sangre en el tejido subcutáneo, membranas, mucosas o piel, que puede generar manifestaciones clínicas de sangrado como lesiones equimóticas, petequias de aparición brusca, epistaxis, gingivorragia y complicaciones graves como hemorragia intracraneal, debido a destrucción plaquetaria mediada por anticuerpos dirigidos contra la superficie de las plaquetas. El objetivo de este informe es presentar las características clínicas de los pacientes con púrpura trombocitopénica idiopática en un hospital de tercer nivel de atención, con la finalidad de tener estadísticas para estudios analíticos posteriores. MÉTODOS: se realizó un estudio descriptivo de 200 pacientes atendidos en el servicio de hematología con diagnóstico de púrpura trombocitopénica idiopática. Se describen sus manifestaciones clínicas, el diagnóstico y el tratamiento médico y quirúrgico empleados.

  8. ASASSN-14ae: A Tidal Disruption Event at 200 Mpc

    CERN Document Server

    Holoien, Thomas W -S; Bersier, D; Kochanek, C S; Stanek, K Z; Shappee, B J; Grupe, D; Basu, U; Beacom, J F; Brimacombe, J; Brown, J S; Davis, A B; Jencson, J; Pojmanski, G; Szczygiel, D M

    2014-01-01

    ASASSN-14ae is a candidate tidal disruption event (TDE) found at the center of SDSS J110840.11+340552.2 ($d\\simeq200$ Mpc) by the All-Sky Automated Survey for Supernovae (ASAS-SN), a global array of 14-cm telescopes. The host galaxy is an early type spiral with no signs of an active galactic nucleus (AGN) and with little recent star formation. We present follow-up photometric and spectroscopic observations of the source, including optical data from ground-based telescopes and ultraviolet and optical data from Swift. From blackbody fits to the host-subtracted spectral energy distribution, we find that the transient had a peak luminosity of $L\\simeq8\\times10^{43}$ erg s$^{-1}$ and a total integrated energy of $E\\simeq1.5\\times10^{50}$ ergs over the $\\sim3$ months of observations presented. The blackbody temperature of the transient remains roughly constant at $T\\sim20,000$ K while the luminosity declines by nearly 1.5 orders of magnitude during this time, a drop that is most consistent with an exponential, $L\\p...

  9. The SEDs of the revised 200 mJy sample

    CERN Document Server

    Antón, S; Marcha, M J M; Bondi, M; Polatidis, A

    2004-01-01

    We address the question of why low-luminosity radio sources with similar flat radio spectra show a range of optical activity. The investigation is based on the spectral energy distributions (SEDs) of objects from the 200 mJy sample. We gathered new data from the VLA at 43 GHz, from SCUBA in the JCMT at 2000, 1350 and 850 micron and from the ISOPHOT instrument on ISO at 170, 90, 60 and 25 micron. There is considerable diversity amongst the SEDs of the objects: there are objects with steep broadband spectra between centimetre and millimetre bands (14% of the sample), there are those with flat broadband spectra over most of the spectral range (48% of the sample) and there are those which show pronounced sub-mm/infrared excesses (27% of the sample). Some objects of the first group have two sided radio morphology indicating that their pc-scale emission is not dominated by beamed jet emission. Amongst the objects that have smooth broadband spectra from the radio to the infrared there are passive elliptical galaxies...

  10. Elastic Precursor Decay in S-200F Beryllium

    Science.gov (United States)

    Adams, Chris; Anderson, William; Blumenthal, William; Gray, George (Rusty), III

    2013-06-01

    We have performed a number of plate impact experiments on vacuum hot-pressed (VHP) S-200F Be at shock stresses between 2.1 and 23 GPa to gain insight into the dynamic strength and damage behavior of this technologically important material. In this discussion we will focus on our observations of dynamic strength represented by the Hugoniot Elastic Limit (HEL) determined from the amplitude of the elastic precursor wave observed in VISAR wave profiles collected at the rear surface of the target for experiments conducted in transmission geometry. We observe monotonic decay in precursor amplitude with run distance for sample thicknesses between 4 and 8 mm. We will discuss the observed precursor decay with respect to the relative roles of twinning and dislocation mediated slip in the overall material mechanical response. We will make comparisons with similar data obtained from experiments conducted on roll-textured plate where the contribution of twinning to initial deformation is expected to be suppressed. C. D. Adams et al., ``Shock Compression of Condensed Matter - 2009,'' AIP Conference Proceedings 1195, 1, 509-512 (2009).

  11. Industry, environment and health through 200 years in Manchester

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, Ian; Hodgson, Rob; Lawson, Nigel [School of Geography, University of Manchester, Mansfield Cooper Building, M13 9PL Manchester (United Kingdom)

    2002-05-01

    The Manchester urban area evolved rapidly in the early 19th century from a series of small towns to a major industrial conurbation with huge material flows and worldwide trade connections. A combination of the availability of nearby coalfields, canals, and free trade, which encouraged entrepreneurial enterprise, made Manchester into the 'shock' city of the industrial revolution. Rapid nucleated urban growth associated with industrialisation throughout the 19th century involved an exponential growth in materials transfers and in waste flows. The 20th century suburban dispersal of residential and industrial growth led to further increase in the impact of the urban metabolism, especially in terms of mass: distance of materials movement. The current post-industrial phase in Greater Manchester has to cope with the environmental and social legacies of its industrial past and with growing per capita materials consumption and increases in number of households despite a nearly static population of around 2.5 million. Changes in material flows, land usage and river morphology in Greater Manchester over the past 200 years have reflected changing technologies, industry, economics, social expectations and environmental legislation. Manchester had the first passenger railway, the first inter-basin domestic water transfer in the UK, the first urban smokeless zones and was part of a pioneering land reclamation partnership in the 1970s. Even so, the environmental legacy of industrial material flows constantly presents new challenges, from the cost of reclaiming contaminated brownfield sites to finding destinations for today's urban waste.

  12. Calibration of the Nikon 200 for Close Range Photogrammetry

    Energy Technology Data Exchange (ETDEWEB)

    Sheriff, Lassana; /City Coll., N.Y. /SLAC

    2010-08-25

    The overall objective of this project is to study the stability and reproducibility of the calibration parameters of the Nikon D200 camera with a Nikkor 20 mm lens for close-range photogrammetric surveys. The well known 'central perspective projection' model is used to determine the camera parameters for interior orientation. The Brown model extends it with the introduction of radial distortion and other less critical variables. The calibration process requires a dense network of targets to be photographed at different angles. For faster processing, reflective coded targets are chosen. Two scenarios have been used to check the reproducibility of the parameters. The first one is using a flat 2D wall with 141 coded targets and 12 custom targets that were previously measured with a laser tracker. The second one is a 3D Unistrut structure with a combination of coded targets and 3D reflective spheres. The study has shown that this setup is only stable during a short period of time. In conclusion, this camera is acceptable when calibrated before each use. Future work should include actual field tests and possible mechanical improvements, such as securing the lens to the camera body.

  13. 24 CFR 200.926c - Model code provisions for use in partially accepted code jurisdictions.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Model code provisions for use in partially accepted code jurisdictions. 200.926c Section 200.926c Housing and Urban Development Regulations... Minimum Property Standards § 200.926c Model code provisions for use in partially accepted...

  14. 29 CFR 780.200 - Inclusion of forestry or lumbering operations in agriculture is limited.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Inclusion of forestry or lumbering operations in agriculture is limited. 780.200 Section 780.200 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR... Lumbering Operations § 780.200 Inclusion of forestry or lumbering operations in agriculture is...

  15. 9 CFR 113.200 - General requirements for killed virus vaccines.

    Science.gov (United States)

    2010-01-01

    ... vaccines. 113.200 Section 113.200 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... REQUIREMENTS Killed Virus Vaccines § 113.200 General requirements for killed virus vaccines. When prescribed in an applicable Standard Requirement or in the filed Outline of Production, a killed virus...

  16. Laboratory Diagnosis and Clinical Profile of Anti-p200 Pemphigoid

    NARCIS (Netherlands)

    Meijer, Joost M.; Diercks, Gilles F. H.; Schmidt, Enno; Pas, Hendri H.; Jonkman, Marcel F.

    2016-01-01

    IMPORTANCE Anti-p200 pemphigoid is a rare subepidermal autoimmune blistering disease characterized by autoantibodies against a 200-kDa protein in the basement membrane zone. Anti-p200 pemphigoid is probably often misdiagnosed because of low availability of diagnostic assays and expertise and classif

  17. 14 CFR 1212.200 - Determining existence of records subject to the Privacy Act.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Determining existence of records subject to the Privacy Act. 1212.200 Section 1212.200 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PRIVACY ACT-NASA REGULATIONS Access to Records § 1212.200 Determining existence of records...

  18. 17 CFR 200.24a - Director of the Office of Consumer Affairs.

    Science.gov (United States)

    2010-04-01

    ... Consumer Affairs. 200.24a Section 200.24a Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.24a Director of the Office of Consumer Affairs. The Director of the Office of Consumer Affairs is responsible to the Chairman for the Commission's investor education and...

  19. 20 CFR 666.200 - Under what circumstances is a State eligible for an Incentive Grant?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Under what circumstances is a State eligible for an Incentive Grant? 666.200 Section 666.200 Employees' Benefits EMPLOYMENT AND TRAINING... Incentives and Sanctions for State Performance § 666.200 Under what circumstances is a State eligible for...

  20. 7 CFR 3015.200 - Acknowledgement of support on publications and audiovisuals.

    Science.gov (United States)

    2010-01-01

    ... audiovisuals. 3015.200 Section 3015.200 Agriculture Regulations of the Department of Agriculture (Continued... Miscellaneous § 3015.200 Acknowledgement of support on publications and audiovisuals. (a) Definitions. Appendix A defines “audiovisual,” “production of an audiovisual,” and “publication.” (b)...

  1. 49 CFR 179.200-19 - Reinforcements, when used, and appurtenances not otherwise specified.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Reinforcements, when used, and appurtenances not otherwise specified. 179.200-19 Section 179.200-19 Transportation Other Regulations Relating to... DOT-111AW and 115AW) § 179.200-19 Reinforcements, when used, and appurtenances not otherwise...

  2. 24 CFR 200.195 - Removal of nonprofit organization from Nonprofit Organization Roster.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Removal of nonprofit organization from Nonprofit Organization Roster. 200.195 Section 200.195 Housing and Urban Development Regulations... Placement and Removal Procedures for Participation in FHA Programs Nonprofit Organization § 200.195...

  3. 17 CFR 200.30-10 - Delegation of authority to Chief Administrative Law Judge.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Delegation of authority to Chief Administrative Law Judge. 200.30-10 Section 200.30-10 Commodity and Securities Exchanges... Organization and Program Management General Organization § 200.30-10 Delegation of authority to...

  4. Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation

    NARCIS (Netherlands)

    N. Koning; M. van Eijk; W. Pouwels; M.S.M. Brouwer; D. Voehringer; I. Huitinga; R.M. Hoek; G. Raes; J. Hamann

    2010-01-01

    Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-4 or IL-13. In mice, peritoneal M2 macrophage

  5. 17 CFR 200.18 - Director of Division of Corporation Finance.

    Science.gov (United States)

    2010-04-01

    ... Corporation Finance. 200.18 Section 200.18 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.18 Director of Division of Corporation Finance. The Director of the Division of Corporation Finance is responsible to the Commission for the administration of all matters (except...

  6. 21 CFR 201.200 - Disclosure of drug efficacy study evaluations in labeling and advertising.

    Science.gov (United States)

    2010-04-01

    ... labeling and advertising. 201.200 Section 201.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Efficacy Study § 201.200 Disclosure of drug efficacy study evaluations in labeling and advertising. (a)(1...), promotional labeling, and advertisements shall include, as part of the information for practitioners...

  7. 12 CFR 550.200 - Must I review a prospective account before I accept it?

    Science.gov (United States)

    2010-01-01

    ... accept it? 550.200 Section 550.200 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE... § 550.200 Must I review a prospective account before I accept it? Before accepting a prospective fiduciary account, you must review it to determine whether you can properly administer the account....

  8. 17 CFR 200.20c - Office of Filings and Information Services.

    Science.gov (United States)

    2010-04-01

    ... Information Services. 200.20c Section 200.20c Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.20c Office of Filings and Information Services. The Office of Filings and Information Services is responsible for the receipt and initial handling of all public documents filed at...

  9. 17 CFR 200.19a - Director of the Division of Trading and Markets.

    Science.gov (United States)

    2010-04-01

    ... Trading and Markets. 200.19a Section 200.19a Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.19a Director of the Division of Trading and Markets. The Director of the Division of Trading and Markets is responsible to the Commission for the administration and execution...

  10. PEROXIDE DESTRUCTION TESTING FOR THE 200 AREA EFFLUENT TREATMENT FACILITY

    Energy Technology Data Exchange (ETDEWEB)

    HALGREN DL

    2010-03-12

    The hydrogen peroxide decomposer columns at the 200 Area Effluent Treatment Facility (ETF) have been taken out of service due to ongoing problems with particulate fines and poor destruction performance from the granular activated carbon (GAC) used in the columns. An alternative search was initiated and led to bench scale testing and then pilot scale testing. Based on the bench scale testing three manganese dioxide based catalysts were evaluated in the peroxide destruction pilot column installed at the 300 Area Treated Effluent Disposal Facility. The ten inch diameter, nine foot tall, clear polyvinyl chloride (PVC) column allowed for the same six foot catalyst bed depth as is in the existing ETF system. The flow rate to the column was controlled to evaluate the performance at the same superficial velocity (gpm/ft{sup 2}) as the full scale design flow and normal process flow. Each catalyst was evaluated on peroxide destruction performance and particulate fines capacity and carryover. Peroxide destruction was measured by hydrogen peroxide concentration analysis of samples taken before and after the column. The presence of fines in the column headspace and the discharge from carryover was generally assessed by visual observation. All three catalysts met the peroxide destruction criteria by achieving hydrogen peroxide discharge concentrations of less than 0.5 mg/L at the design flow with inlet peroxide concentrations greater than 100 mg/L. The Sud-Chemie T-2525 catalyst was markedly better in the minimization of fines and particle carryover. It is anticipated the T-2525 can be installed as a direct replacement for the GAC in the peroxide decomposer columns. Based on the results of the peroxide method development work the recommendation is to purchase the T-2525 catalyst and initially load one of the ETF decomposer columns for full scale testing.

  11. Ascending phlebography of the legs with Solutrast 200

    Energy Technology Data Exchange (ETDEWEB)

    Tuengerthal, S.

    1984-10-01

    This is a report on an open clinical test with the X-ray contrast medium Jopamidol, which is non-ionic and therefore osmolarity-reduced. It has an iodine content of 200 mg iodine/ml and was found to be useful for the demonstration of the peripheral and central veins. 92.9 per cent of all examinations, using an injected dose of mostly 50 ml of the agent, permitted satisfactory contrasting of the veins of the lower extremities including the pelvic veins. Because the contrast solution flows off quickly it is possible in spite of the low iodine content to obtain a fair demonstration of discrete alterations of the vessel walls of peripheral veins, and to document the veins, in the abdomen at the same time. The systemic tolerance of the agent is good. 96.7 per cent of the patients showed no symptoms after the contrast medium was injected, one patient exhibited mild signs of hypergenetic reaction to the X-ray contrast medium (urticaria). Side effects were seen in 3.3 per cent of the patients and were in all cases non-threatening. The local tolerance is excellent. 86.6 per cent did not experience disagreeable sensations in the extremity examined. Only one patient reported great pain during the examination. Clinical and nuclear investigations after the phlebography did not suffer from thrombophlebitic complications. The fastness of the investigation and good local tolerance of the contrast solution reduce the risk involved with the phlebography especially in at-risk patients.

  12. The Use of Ion Chromatography for the Determination of Clean-In-Place-200 (CIP-200 Detergent Traces

    Directory of Open Access Journals (Sweden)

    Héctor Colón

    2006-01-01

    Full Text Available Anion chromatography with conductivity detection was chosen as the analytical technique for the development of a cleaning validation method for clean-in-place (CIP detergents. The method was developed and validated for the determination of traces of the detergent CIP-200. It was shown to be linear with a squared correlation coefficient (r2 of 0.9999 and the accuracy experiments presented average recoveries of 88.2% (area response factor from stainless steel surfaces. The repeatability was found to be 1.6% and an intermediate precision of 1.9% across the range. The method was also shown to be sensitive with an average Detection Limit (DL of 0.23 ppm and a Quantitation Limit (QL of 0.70 ppm based on the amount of phosphate in the detergent sample. The phosphate signal was well resolved from typical ions encountered in water samples or any other interference presented from swabs and surfaces. The method was applied to cleaning validation samples and proved to be suitable for rapid and reliable quality control.

  13. Calculo de tanque de PRFV de 200 000 litros de capacidad. // 200 000 liters capacity PRFV tank calculation.

    Directory of Open Access Journals (Sweden)

    J. García de la Figal Costales

    2002-01-01

    Full Text Available La tarea que se acomete es el cálculo a resistencia y rigidez de un tanque para el almacenamiento de agua, de 200 000 litrosde capacidad, construido de plástico reforzado con fibras de vidrio, PRFV. El mismo es cilíndrico vertical, de 8 metros dediámetro por 4.2 metros de altura. Los materiales seleccionados para la conformación de las láminas con las que se haránlos laminados de PRFV, fueron: resina poliéster isosftálica, y fibras de vidrio E.La carga fundamental a soportar por el tanque será la presión debida a la columna de agua en su interior, pero por estar a laintemperie y en zona de playa, se considerará también la acción de las dilataciones debidas a la temperatura, así como laacción de un ciclón.Palabras claves: resistencia, recipiente, composites, elementos finitos._____________________________________________________________________________Abstract.The stress and strains calculation of a water reinforced fiber glass container is carried out by means of a modern FiniteElement program, because the high complexity of calculus. The soported main load is the pressure caused by the column ofwater.Key words: Resistance, vessels, composites, finite elements.

  14. Characterization of Biofilm in 200W Fluidized Bed Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Michelle H.; Saurey, Sabrina D.; Lee, Brady D.; Parker, Kent E.; Eisenhauer, Emalee ER; Cordova, Elsa A.; Golovich, Elizabeth C.

    2014-09-29

    Contaminated groundwater beneath the 200 West Area at the Hanford Site in Southeast Washington is currently being treated using a pump and treat system to remove organics, inorganics, radionuclides, and metals. A granular activated carbon-based fluidized bed reactor (FBR) has been added to remove nitrate, hexavalent chromium and carbon tetrachloride. Initial analytical results indicated the microorganisms effectively reduced many of the contaminants to less than cleanup levels. However shortly thereafter operational upsets of the FBR include carbon carry over, over production of microbial extracellular polymeric substance (biofilm) materials, and over production of hydrogen sulfide. As a result detailed investigations were undertaken to understand the functional diversity and activity of the microbial community present in the FBR over time. Molecular analyses including terminal restriction fragment length polymorphism analysis, quantitative polymerase chain reaction and fluorescent in situ hybridization analyses were performed on the microbial community extracted from the biofilm within the bed and from the inoculum, to determine functional dynamics of the FBR bed over time and following operational changes. Findings from these analyses indicated: 1) the microbial community within the bed was completely different than community used for inoculation, and was likely from the groundwater; 2) analyses early in the testing showed an FBR community dominated by a few Curvibacter and Flavobacterium species; 3) the final sample taken indicated that the microbial community in the FBR bed had become more diverse; and 4) qPCR analyses indicated that bacteria involved in nitrogen cycling, including denitrifiers and anaerobic ammonia oxidizing bacteria, were dominant in the bed. These results indicate that molecular tools can be powerful for determining functional diversity within FBR type reactors. Coupled with micronutrient, influent and effluent chemistry evaluations, a more

  15. CEBAF 200 kV Inverted Electron Gun

    Energy Technology Data Exchange (ETDEWEB)

    Grames, J M; Clark, J; Hansknecht, J; Poelker, M; Stutzman, M L; Suleiman, R; Surles-Law, K.E.L.; BastaniNejad, M

    2011-03-01

    Two DC high volt­age GaAs pho­to­guns have been built at Jef­fer­son Lab based on a com­pact in­vert­ed in­su­la­tor de­sign. One pho­to­gun pro­vides the po­lar­ized elec­tron beam at CEBAF and op­er­ates at 130 kV bias volt­age. The other gun is used for high av­er­age cur­rent life­time stud­ies at a ded­i­cat­ed test fa­cil­i­ty and has been op­er­at­ed at bias volt­age up to 225 kV. The ad­van­tages of high­er DC volt­age for CEBAF in­clude re­duced space-charge emit­tance growth and the po­ten­tial for pro­longed pho­to­cath­ode life­time. How­ev­er, a con­se­quence of op­er­at­ing at high­er volt­ages is the in­creased like­li­hood of field emis­sion or break­down, both of which are un­ac­cept­able. High­lights of the R&D stud­ies lead­ing to­ward a pro­duc­tion 200keV GaAs pho­to­gun for CEBAF will be pre­sent­ed.

  16. Learn from experience: insights of 200+ PACS customers.

    Science.gov (United States)

    Swaton, Norm

    2002-01-01

    This article is based on a PACS study published in June 2001 by KLAS Enterprises. The study offers unique insight into the performance, underlying technology, product depth and breadth, and "real world" issues facing 10 of the leading PACS vendors and their clients as rated at more than 200 of their client sites by CIOs, department directors and vendor executives. The driving force behind this report reflects the heightened interest in PACS systems in general and PACS' contributions to the benefits associated with an electronic medical record. This research was sponsored by 10 healthcare provider organizations (not vendors), ranging from a 150-bed acute-care hospital to a seven-hospital IDN. Most of the data in the report focuses on the use of PACS in the radiology department, since comparatively few sites are using PACS systems in other departments, such as cardiology or pathology. The participating vendors supplied their customer lists, which contributed to the majority of clients surveyed. Clients surveyed in the study vary widely in size, ranging from 50 to 2,000 beds, with about 46 percent of those surveyed having a hospital size of more than 400 beds. The customers represent a broad cross-section of PACS clients, ranging from 10 percent to 95 percent filmless, with large-scale users making up the majority of respondents. Each of the customers were asked to numerically rate their vendor on 28 aspects of performance, as well as to answer 12 questions relating to customer satisfaction. Based on study results, success with PACS can be distilled into some basic principles. There are other issues that will help with a successful PACS selection and implementation, but the following list should help anyone get started. If you are able to focus on and accomplish these few things, you stand a better chance of building and meeting your business case. Pre-sell your PACS concept to the radiologists, technicians, IS/IT staff supporting it and to the referring physicians

  17. Characterization of biofilm in 200W fluidized bed reactors

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Michelle H. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Saurey, Sabrina D. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Lee, Brady D. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Parker, Kent E. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Eisenhauer, Emalee E. R. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Cordova, Elsa A. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Golovich, Elizabeth C. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

    2014-09-29

    Contaminated groundwater beneath the 200 West Area at the Hanford Site in Southeast Washington is currently being treated using a pump and treat system to remove organics, inorganics, radionuclides, and metals. A granular activated carbon-based fluidized bed reactor (FBR) has been added to remove nitrate, hexavalent chromium and carbon tetrachloride. Initial analytical results indicated the microorganisms effectively reduced many of the contaminants to less than cleanup levels. However shortly thereafter operational upsets of the FBR include carbon carry over, over production of microbial extracellular polymeric substance (biofilm) materials, and over production of hydrogen sulfide. As a result detailed investigations were undertaken to understand the functional diversity and activity of the microbial community present in the FBR over time. Molecular analyses including terminal restriction fragment length polymorphism analysis, quantitative polymerase chain reaction and fluorescent in situ hybridization analyses were performed on the microbial community extracted from the biofilm within the bed and from the inoculum, to determine functional dynamics of the FBR bed over time and following operational changes. Findings from these analyses indicated: 1) the microbial community within the bed was completely different than community used for inoculation, and was likely from the groundwater; 2) analyses early in the testing showed an FBR community dominated by a few Curvibacter and Flavobacterium species; 3) the final sample taken indicated that the microbial community in the FBR bed had become more diverse; and 4) qPCR analyses indicated that bacteria involved in nitrogen cycling, including denitrifiers and anaerobic ammonia oxidizing bacteria, were dominant in the bed. These results indicate that molecular tools can be powerful for determining functional diversity within FBR type reactors. Coupled with micronutrient, influent and effluent chemistry

  18. Honeywell HPA200精密气压计测量异常现象分析%Abnormal measure analysis of the Honeywell HPA200 precision barometer

    Institute of Scientific and Technical Information of China (English)

    张栋

    2011-01-01

    In order to solve the transnormal error which measured by the Honeywell HPA200 precision barometer,factors that related to the phenomenon are compared. The EMI characters of the HPA200 barometer have been found that the basic factor is the 400 MHz wireless interphone. Then,the hardware of the LC band reject filter is designed to lower the measure error value by the HPA200 precision barometer. The measure error is obviously reduced by the HPA200 barometer with the LC band reject filter in practice,and the ability of the anti-EMI is improved. Finally,the measure accuracy of the system demand is met by the HPA200 barometer with the LC band reject filter.%为了解决Honeywell HPA200精密气压计出现的严重超标的测量异常现象,通过分析对比相关的因素,查找验证HPA200精密气压计受到400 MHz无线对讲机的电磁干扰,依此设计硬件LC带阻滤波器,来滤除400 MHz左右的确定性干扰信号.最终通过实际测试和验证,LC带阻滤波器可以增强HPA200精密气压计抗干扰能力,降低气压计测量误差,并达到HPA200精密气压计的测量指标要求.

  19. miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus

    Institute of Scientific and Technical Information of China (English)

    Cameron M Smith; David I Watson; Mary P Leong; George C Mayne; Michael Z Michael; Bas PL Wijnhoven; Damian J Hussey

    2011-01-01

    AIM:To investigate miR-200 family expression in Barrett's epithelium,gastric and duodenal epithelia,and esophageal adenocarcinoma. METHODS:Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200,ZEB1 and ZEB2 expression.Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS:Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001).In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenal epithelia,and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02),and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02).The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium.We observed significant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION:miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium.

  20. Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system.

    Science.gov (United States)

    Hernangómez, Miriam; Carrillo-Salinas, Francisco J; Mecha, Miriam; Correa, Fernando; Mestre, Leyre; Loría, Frida; Feliú, Ana; Docagne, Fabian; Guaza, Carmen

    2014-01-01

    The central nervous system (CNS) innate immune response includes an arsenal of molecules and receptors expressed by professional phagocytes, glial cells and neurons that is involved in host defence and clearance of toxic and dangerous cell debris. However, any uncontrolled innate immune responses within the CNS are widely recognized as playing a major role in the development of autoimmune disorders and neurodegeneration, with multiple sclerosis (MS) Alzheimer's disease (AD) being primary examples. Hence, it is important to identify the key regulatory mechanisms involved in the control of CNS innate immunity and which could be harnessed to explore novel therapeutic avenues. Neuroimmune regulatory proteins (NIReg) such as CD95L, CD200, CD47, sialic acid, complement regulatory proteins (CD55, CD46, fH, C3a), HMGB1, may control the adverse immune responses in health and diseases. In the absence of these regulators, when neurons die by apoptosis, become infected or damaged, microglia and infiltrating immune cells are free to cause injury as well as an adverse inflammatory response in acute and chronic settings. We will herein provide new emphasis on the role of the pair CD200-CD200R in MS and its experimental models: experimental autoimmune encephalomyelitis (EAE) and Theiler's virus induced demyelinating disease (TMEV-IDD). The interest of the cannabinoid system as inhibitor of inflammation prompt us to introduce our findings about the role of endocannabinoids (eCBs) in promoting CD200-CD200 receptor (CD200R) interaction and the benefits caused in TMEV-IDD. Finally, we also review the current data on CD200-CD200R interaction in AD, as well as, in the aging brain.

  1. SRP engineering and design history, Vol III, 200 F and H Areas

    Energy Technology Data Exchange (ETDEWEB)

    Banick, C.J.

    2000-04-17

    This volume combines the record of events relating to the development of design for both the 200-F and H Areas. Chronologically, the definition of plant facilities was first established for the 200-F Area. The second area, 200-H, was projected initially to be a supplementary plutonium separations facility. This history explains the differences in character and capacity of the manufacturing facilities in both areas as production requirements and experience with separations processes advanced.

  2. Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish

    Directory of Open Access Journals (Sweden)

    Yuan Liu

    2015-01-01

    Full Text Available Purpose. The small nuclear ribonucleoprotein 200 kDa (SNRNP200 gene is a fundamental component for precursor message RNA (pre-mRNA splicing and has been implicated in the etiology of autosomal dominant retinitis pigmentosa (adRP. This study aims to determine the consequences of knocking down Snrnp200 in zebrafish. Methods. Expression of the Snrnp200 transcript in zebrafish was determined via whole mount in situ hybridization. Morpholino oligonucleotide (MO aiming to knock down the expression of Snrnp200 was injected into zebrafish embryos, followed by analyses of aberrant splicing and expression of the U4/U6-U5 tri-small nuclear ribonucleoproteins (snRNPs components and retina-specific transcripts. Systemic changes and retinal phenotypes were further characterized by histological study and immunofluorescence staining. Results. Snrnp200 was ubiquitously expressed in zebrafish. Knocking down Snrnp200 in zebrafish triggered aberrant splicing of the cbln1 gene, upregulation of other U4/U6-U5 tri-snRNP components, and downregulation of a panel of retina-specific transcripts. Systemic defects were found correlated with knockdown of Snrnp200 in zebrafish. Only demorphogenesis of rod photoreceptors was detected in the initial stage, mimicking the disease characteristics of RP. Conclusions. We conclude that knocking down Snrnp200 in zebrafish could alter regular splicing and expression of a panel of genes, which may eventually trigger rod defects.

  3. Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish.

    Science.gov (United States)

    Liu, Yuan; Chen, Xue; Qin, Bing; Zhao, Kanxing; Zhao, Qingshun; Staley, Jonathan P; Zhao, Chen

    2015-01-01

    Purpose. The small nuclear ribonucleoprotein 200 kDa (SNRNP200) gene is a fundamental component for precursor message RNA (pre-mRNA) splicing and has been implicated in the etiology of autosomal dominant retinitis pigmentosa (adRP). This study aims to determine the consequences of knocking down Snrnp200 in zebrafish. Methods. Expression of the Snrnp200 transcript in zebrafish was determined via whole mount in situ hybridization. Morpholino oligonucleotide (MO) aiming to knock down the expression of Snrnp200 was injected into zebrafish embryos, followed by analyses of aberrant splicing and expression of the U4/U6-U5 tri-small nuclear ribonucleoproteins (snRNPs) components and retina-specific transcripts. Systemic changes and retinal phenotypes were further characterized by histological study and immunofluorescence staining. Results. Snrnp200 was ubiquitously expressed in zebrafish. Knocking down Snrnp200 in zebrafish triggered aberrant splicing of the cbln1 gene, upregulation of other U4/U6-U5 tri-snRNP components, and downregulation of a panel of retina-specific transcripts. Systemic defects were found correlated with knockdown of Snrnp200 in zebrafish. Only demorphogenesis of rod photoreceptors was detected in the initial stage, mimicking the disease characteristics of RP. Conclusions. We conclude that knocking down Snrnp200 in zebrafish could alter regular splicing and expression of a panel of genes, which may eventually trigger rod defects.

  4. Comparison of the Nellcor N-200 and N-3000 pulse oximeters during simulated postoperative activities

    DEFF Research Database (Denmark)

    Lie, C; Kehlet, H; Rosenberg, J

    1997-01-01

    Twenty-six healthy volunteers were monitored simultaneously with the Nellcor N-200 and N-3000 pulse oximeters during nonhypoxaemic simulated postoperative activity. The overall number of registered events (hypoxaemic episodes or loss of signal) was fewer with the N-3000 than with the N-200 (8 vs...... to loss of signal were significantly rarer with the N-3000 than with the N-200 (3 vs. 13, p = 0.001). The Nellcor N-3000 oximeter may offer an advantage over the N-200 model when monitoring patients in the postoperative period....

  5. 浦项钢铁停止生产200系不锈钢

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    今年初浦项钢铁成功研制出200系(镍含量4%),但是没有生产。浦项钢铁不生产200系的原因是,200系被贸易商作为300系销售的情况频频发生,而且200系的质量问题持续发生,此外,国际不锈钢生产商都不生产200系,所以浦项钢铁决定不生产200系。现在韩国200系进口量越来越多,200系主要进口品种是镍含量1%和4%,其中主要进口镍含量1%的200系不锈钢,主要进口国是中国、印度和中国台湾地区。

  6. FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells.

    Science.gov (United States)

    Liu, Fei; Lee, Jae Y; Wei, Huijun; Tanabe, Osamu; Engel, James D; Morrison, Sean J; Guan, Jun-Lin

    2010-12-02

    Little is known about whether autophagic mechanisms are active in hematopoietic stem cells (HSCs) or how they are regulated. FIP200 (200-kDa FAK-family interacting protein) plays important roles in mammalian autophagy and other cellular functions, but its role in hematopoietic cells has not been examined. Here we show that conditional deletion of FIP200 in hematopoietic cells leads to perinatal lethality and severe anemia. FIP200 was cell-autonomously required for the maintenance and function of fetal HSCs. FIP200-deficient HSC were unable to reconstitute lethally irradiated recipients. FIP200 ablation did not result in increased HSC apoptosis, but it did increase the rate of HSC proliferation. Consistent with an essential role for FIP200 in autophagy, FIP200-null fetal HSCs exhibited both increased mitochondrial mass and reactive oxygen species. These data identify FIP200 as a key intrinsic regulator of fetal HSCs and implicate a potential role for autophagy in the maintenance of fetal hematopoiesis and HSCs.

  7. RNA recognition by a human antibody against brain cytoplasmic 200 RNA.

    Science.gov (United States)

    Jung, Euihan; Lee, Jungmin; Hong, Hyo Jeong; Park, Insoo; Lee, Younghoon

    2014-06-01

    Diverse functional RNAs participate in a wide range of cellular processes. The RNA structure is critical for function, either on its own or as a complex form with proteins and other ligands. Therefore, analysis of the RNA conformation in cells is essential for understanding their functional mechanisms. However, no appropriate methods have been established as yet. Here, we developed an efficient strategy for panning and affinity maturation of anti-RNA human monoclonal antibodies from a naïve antigen binding fragment (Fab) combinatorial phage library. Brain cytoplasmic 200 (BC200) RNA, which is also highly expressed in some tumors, was used as an RNA antigen. We identified MabBC200-A3 as the optimal binding antibody. Mutagenesis and SELEX experiments showed that the antibody recognized a domain of BC200 in a structure- and sequence-dependent manner. Various breast cancer cell lines were further examined for BC200 RNA expression using conventional hybridization and immunoanalysis with MabBC200-A3 to see whether the antibody specifically recognizes BC200 RNA among the total purified RNAs. The amounts of antibody-recognizable BC200 RNA were consistent with hybridization signals among the cell lines. Furthermore, the antibody was able to discriminate BC200 RNA from other RNAs, supporting the utility of this antibody as a specific RNA structure-recognizing probe. Intriguingly, however, when permeabilized cells were subjected to immunoanalysis instead of purified total RNA, the amount of antibody-recognizable RNA was not correlated with the cellular level of BC200 RNA, indicating that BC200 RNA exists as two distinct forms (antibody-recognizable and nonrecognizable) in breast cancer cells and that their distribution depends on the cell type. Our results clearly demonstrate that anti-RNA antibodies provide an effective novel tool for detecting and analyzing RNA conformation.

  8. Application of new techniques to renovation of 200 MW steam turbine

    Institute of Scientific and Technical Information of China (English)

    陈浮; 宋彦萍; 王仲奇

    2001-01-01

    Presents the new techniques leading to the improvements in aerodynamics of 200MW steam turbine high-pressure cylinder and mid-pressure cylinder, discusses the rearloaded profile and blade bowing, and concludes from numerical simulation and experimental results that the application of rearloaded profile and blade bowing has improved the performance of 200 MW unit.

  9. 24 CFR 1710.200 - Instructions for Statement of Record, Additional Information and Documentation.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Instructions for Statement of Record, Additional Information and Documentation. 1710.200 Section 1710.200 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER,...

  10. 24 CFR 200.947 - Building product standards and certification program for polystyrene foam insulation board.

    Science.gov (United States)

    2010-04-01

    ... certification program for polystyrene foam insulation board. 200.947 Section 200.947 Housing and Urban... program for polystyrene foam insulation board. (a) Applicable standards. (1) All polystyrene foam... Testing and Materials (ASTM) standard C-578-92, Standard Specification for Rigid, Cellular...

  11. 24 CFR 200.77 - Lead-based paint poisoning prevention.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Lead-based paint poisoning prevention. 200.77 Section 200.77 Housing and Urban Development Regulations Relating to Housing and Urban...-based paint poisoning prevention. Requirements set forth in 24 CFR part 35 apply to these programs....

  12. 49 CFR 179.200-23 - Tests of pressure relief valves.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Tests of pressure relief valves. 179.200-23 Section 179.200-23 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS...-23 Tests of pressure relief valves. (a) Each valve shall be tested by air or gas for compliance...

  13. 40 CFR 270.200 - How may I renew my RAP if it is expiring?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false How may I renew my RAP if it is expiring? 270.200 Section 270.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... renew my RAP if it is expiring? If you wish to renew your expiring RAP, you must follow the process...

  14. MiR-200c regulates Noxa expression and sensitivity to proteasomal inhibitors.

    Science.gov (United States)

    Lerner, Mikael; Haneklaus, Moritz; Harada, Masako; Grandér, Dan

    2012-01-01

    The pro-apoptotic p53 target Noxa is a BH3-only protein that antagonizes the function of selected anti-apoptotic Bcl-2 family members. While much is known regarding the transcriptional regulation of Noxa, its posttranscriptional regulation remains relatively unstudied. In this study, we therefore investigated whether Noxa is regulated by microRNAs. Using a screen combining luciferase reporters, bioinformatic target prediction analysis and microRNA expression profiling, we identified miR-200c as a negative regulator of Noxa expression. MiR-200c was shown to repress basal expression of Noxa, as well as Noxa expression induced by various stimuli, including proteasomal inhibition. Luciferase reporter experiments furthermore defined one miR-200c target site in the Noxa 3'UTR that is essential for this direct regulation. In spite of the miR-200c:Noxa interaction, miR-200c overexpression led to increased sensitivity to the clinically used proteasomal inhibitor bortezomib in several cell lines. This apparently contradictory finding was reconciled by the fact that in cells devoid of Noxa expression, miR-200c overexpression had an even more pronounced positive effect on apoptosis induced by proteasomal inhibition. Together, our data define miR-200c as a potentiator of bortezomib-induced cell death. At the same time, we show that miR-200c is a novel negative regulator of the pro-apoptotic Bcl-2 family member Noxa.

  15. MiR-200c regulates Noxa expression and sensitivity to proteasomal inhibitors.

    Directory of Open Access Journals (Sweden)

    Mikael Lerner

    Full Text Available The pro-apoptotic p53 target Noxa is a BH3-only protein that antagonizes the function of selected anti-apoptotic Bcl-2 family members. While much is known regarding the transcriptional regulation of Noxa, its posttranscriptional regulation remains relatively unstudied. In this study, we therefore investigated whether Noxa is regulated by microRNAs. Using a screen combining luciferase reporters, bioinformatic target prediction analysis and microRNA expression profiling, we identified miR-200c as a negative regulator of Noxa expression. MiR-200c was shown to repress basal expression of Noxa, as well as Noxa expression induced by various stimuli, including proteasomal inhibition. Luciferase reporter experiments furthermore defined one miR-200c target site in the Noxa 3'UTR that is essential for this direct regulation. In spite of the miR-200c:Noxa interaction, miR-200c overexpression led to increased sensitivity to the clinically used proteasomal inhibitor bortezomib in several cell lines. This apparently contradictory finding was reconciled by the fact that in cells devoid of Noxa expression, miR-200c overexpression had an even more pronounced positive effect on apoptosis induced by proteasomal inhibition. Together, our data define miR-200c as a potentiator of bortezomib-induced cell death. At the same time, we show that miR-200c is a novel negative regulator of the pro-apoptotic Bcl-2 family member Noxa.

  16. 21 CFR 178.3750 - Polyethylene glycol (mean molecular weight 200-9,500).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Polyethylene glycol (mean molecular weight 200-9..., PRODUCTION AIDS, AND SANITIZERS Certain Adjuvants and Production Aids § 178.3750 Polyethylene glycol (mean molecular weight 200-9,500). Polyethylene glycol identified in this section may be safely used as...

  17. 21 CFR 172.820 - Polyethylene glycol (mean molecular weight 200-9,500).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Polyethylene glycol (mean molecular weight 200-9... ADDITION TO FOOD FOR HUMAN CONSUMPTION Multipurpose Additives § 172.820 Polyethylene glycol (mean molecular weight 200-9,500). Polyethylene glycol identified in this section may be safely used in food...

  18. 28 CFR 200.1 - Eligibility for Protection under the Convention Against Torture.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Eligibility for Protection under the Convention Against Torture. 200.1 Section 200.1 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED... in the United States Senate resolution of ratification of the Convention, as implemented by...

  19. 30 CFR 243.200 - How do I demonstrate financial solvency?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I demonstrate financial solvency? 243.200 Section 243.200 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS REVENUE MANAGEMENT Financial...

  20. 24 CFR 200.194 - Placement of nonprofit organization on Nonprofit Organization Roster.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Placement of nonprofit organization on Nonprofit Organization Roster. 200.194 Section 200.194 Housing and Urban Development Regulations... Placement and Removal Procedures for Participation in FHA Programs Nonprofit Organization §...

  1. 13 CFR 123.200 - Am I eligible to apply for a physical disaster business loan?

    Science.gov (United States)

    2010-01-01

    ..., corporation, limited liability company, or other legal entity recognized under State law. Your business' size... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Am I eligible to apply for a physical disaster business loan? 123.200 Section 123.200 Business Credit and Assistance SMALL...

  2. Functional Role of the microRNA-200 Family in Breast Morphogenesis and Neoplasia

    Directory of Open Access Journals (Sweden)

    Bylgja Hilmarsdottir

    2014-09-01

    Full Text Available Branching epithelial morphogenesis is closely linked to epithelial-to-mesenchymal transition (EMT, a process important in normal development and cancer progression. The miR-200 family regulates epithelial morphogenesis and EMT through a negative feedback loop with the ZEB1 and ZEB2 transcription factors. miR-200 inhibits expression of ZEB1/2 mRNA, which in turn can down-regulate the miR-200 family that further results in down-regulation of E-cadherin and induction of a mesenchymal phenotype. Recent studies show that the expression of miR-200 genes is high during late pregnancy and lactation, thereby indicating that these miRs are important for breast epithelial morphogenesis and differentiation. miR-200 genes have been studied intensively in relation to breast cancer progression and metastasis, where it has been shown that miR-200 members are down-regulated in basal-like breast cancer where the EMT phenotype is prominent. There is growing evidence that the miR-200 family is up-regulated in distal breast metastasis indicating that these miRs are important for colonization of metastatic breast cancer cells through induction of mesenchymal to epithelial transition. The dual role of miR-200 in primary and metastatic breast cancer is of interest for future therapeutic interventions, making it important to understand its role and interacting partners in more detail.

  3. 7 CFR 25.200 - Nominations by State and local governments.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Nominations by State and local governments. 25.200... COMMUNITIES Nomination Procedure § 25.200 Nominations by State and local governments. (a) Nomination criteria. One or more local governments and the States in which an area is located must nominate such area...

  4. 34 CFR 200.80 - Migrant Education Even Start Program definition.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Migrant Education Even Start Program definition. 200.80... DISADVANTAGED Even Start Family Literacy Program § 200.80 Migrant Education Even Start Program definition. Eligible participants under the Migrant Education Even Start Program (MEES) must meet the definitions of...

  5. Mir-200 family expression is downregulated upon neoplastic progression of barrett's esophagus

    NARCIS (Netherlands)

    C.M. Smith; D.I. Watson (David); M.P. Leong (Mary P); L.V. Mayne; M.Z. Michael; B.P.L. Wijnhoven (Bas); D.J. Hussey

    2011-01-01

    textabstractAIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of mi

  6. Development of a 200kW multi-fuel type PAFC power plant

    Energy Technology Data Exchange (ETDEWEB)

    Take, Tetsuo; Kuwata, Yutaka; Adachi, Masahito; Ogata, Tsutomu [NTT Integrated Information & Energy System Labs., Tokyo (Japan)

    1996-12-31

    Nippon Telegraph and Telephone Corporation (NFT) has been developing a 200 kW multi-fuel type PAFC power plant which can generate AC 200 kW of constant power by switching fuel from pipeline town gas to liquefied propane gas (LPG) and vice versa. This paper describes the outline of the demonstration test plant and test results of its fundamental characteristics.

  7. 40 CFR 246.200-2 - Recommended procedures: High-grade paper recovery from smaller offices.

    Science.gov (United States)

    2010-07-01

    ... offices. The recovery of high-grade paper generated by office facilities of less than 100 office workers... paper recovery from smaller offices. 246.200-2 Section 246.200-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE SEPARATION FOR MATERIALS RECOVERY GUIDELINES...

  8. 29 CFR 2530.200a-2 - Treasury regulations for purposes of the Act.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Treasury regulations for purposes of the Act. 2530.200a-2... BENEFIT PLANS Scope and General Provisions § 2530.200a-2 Treasury regulations for purposes of the Act. Regulations prescribed by the Secretary of the Treasury or his delegate under sections 410 and 411 of the...

  9. 31 CFR 363.200 - What Treasury securities does this subpart govern?

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false What Treasury securities does this subpart govern? 363.200 Section 363.200 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT...

  10. 17 CFR 200.30-1 - Delegation of authority to Director of Division of Corporation Finance.

    Science.gov (United States)

    2010-04-01

    ... Director of Division of Corporation Finance. 200.30-1 Section 200.30-1 Commodity and Securities Exchanges... Division of Corporation Finance. Pursuant to the provisions of Pub. L., No. 87-592, 76 Stat. 394 (15 U.S.C... otherwise, the following functions to the Director of the Division of Corporation Finance, to be...

  11. 20 CFR 663.200 - What are intensive services for adults and dislocated workers?

    Science.gov (United States)

    2010-04-01

    ... experience is a planned, structured learning experience that takes place in a workplace for a limited period of time. Work experience may be paid or unpaid, as appropriate. A work experience workplace may be in... dislocated workers? 663.200 Section 663.200 Employees' Benefits EMPLOYMENT AND TRAINING...

  12. 24 CFR 200.950 - Building product standards and certification program for solar water heating system.

    Science.gov (United States)

    2010-04-01

    ... certification program for solar water heating system. 200.950 Section 200.950 Housing and Urban Development... solar water heating system. (a) Applicable standards. (1) All solar water heating systems shall be...) Document OG-300-93, Operating Guidelines and Minimum Standards for Certifying Solar Water Heating...

  13. 34 CFR 200.65 - Determining equitable participation of teachers and families of participating private school...

    Science.gov (United States)

    2010-07-01

    ... proportionate to the number of private school children from low-income families residing in participating public... families of participating private school children. 200.65 Section 200.65 Education Regulations of the... Determining equitable participation of teachers and families of participating private school children....

  14. A Truncated form of CD200 (CD200S Expressed on Glioma Cells Prolonged Survival in a Rat Glioma Model by Induction of a Dendritic Cell-Like Phenotype in Tumor-Associated Macrophages

    Directory of Open Access Journals (Sweden)

    Kana Kobayashi

    2016-04-01

    Full Text Available CD200 induces immunosuppression in myeloid cells expressing its receptor CD200R, which may have consequences for tumor immunity. We found that human carcinoma tissues express not only full-length CD200 (CD200L but also its truncated form, CD200S. Although CD200S is reported to antagonize the immunosuppressive actions of CD200L, the role of CD200S in tumor immunity has never been investigated. We established rat C6 glioma cell lines that expressed either CD200L or CD200S; the original C6 cell line did not express CD200 molecules. The cell lines showed no significant differences in growth. Upon transplantation into the neonatal Wistar rat forebrain parenchyma, rats transplanted with C6-CD200S cells survived for a significantly longer period than those transplanted with the original C6 and C6-CD200L cells. The C6-CD200S tumors were smaller than the C6-CD200L or C6-original tumors, and many apoptotic cells were found in the tumor cell aggregates. Tumor-associated macrophages (TAMs in C6-CD200S tumors displayed dendritic cell (DC-like morphology with multiple processes and CD86 expression. Furthermore, CD3+, CD4+ or CD8+ cells were more frequently found in C6-CD200S tumors, and the expression of DC markers, granzyme, and perforin was increased in C6-CD200S tumors. Isolated TAMs from original C6 tumors were co-cultured with C6-CD200S cells and showed increased expression of DC markers. These results suggest that CD200S activates TAMs to become DC-like antigen presenting cells, leading to the activation of CD8+ cytotoxic T lymphocytes, which induce apoptotic elimination of tumor cells. The findings on CD200S action may provide a novel therapeutic modality for the treatment of carcinomas.

  15. Changes of serum levels of miR-200b and miR-200c in patients with gastric cancer and its clinical significance%胃癌患者血清miR-200b和miR-200c水平变化及临床意义

    Institute of Scientific and Technical Information of China (English)

    陈志凯; 傅松维; 鲍舟君; 李卓栋

    2016-01-01

    目的 观察胃癌患者血清miR-200b和miR-200c水平变化特点,探讨其临床意义.方法 回顾性分析浙江省舟山医院自2012年1月~2014年6月消化内科及胃肠外科收治的84例胃癌患者为研究对象(观察组),选择30例健康人为对照组.采用qRT-PCR检测所有研究对象血清miR-200b和miR-200c水平,比较2组间血清miR-200b和miR-200c水平差异,探讨胃癌患者血清miR-200b和miR-200c水平与其临床及病理特点之间的关系.结果 胃癌组血清miR-200b和miR-200c水平均明显低于对照组,差异均有统计学意义(均P <0.05).胃癌患者不同年龄、性别、分化程度和浸润深度之间血清miR-200b和miR-200c水平差异无统计学意义;较高临床分期及合并淋巴结转移的患者血清miR-200b和miR-200c水平明显低于较低临床分期和无淋巴结转移者,差异均有统计学意义(均P <0.05).血清miR-200b和miR-200c水平诊断胃癌的AUC分别为0.826(95% CI:0.741 ~ 0.911,P<0.001)和0.856(95%CI:0.778 ~0.935,P<0.001).结论 胃癌患者血清miR-200b和miR-200c水平明显降低,并且与临床分期和淋巴结转移密切相关,检测血清miR-200b和miR-200c水平有助于判断胃癌并判断预后.

  16. Structural Features and In-service Inspection of the LTNHR-200 Pressure Vessel

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The pressure vessel of 200 MW low temperature nuclear heating reactor (LTNHR-200) is the main part of primary pressure boundary and its reasonable and reliable structural design is the key point to assure the safe operation of LTNHR-200. The double-shell pressure vessels were designed. LTNHR-200 pressure vessel meets the condition of Leak Before Break and has a relatively low failure probability. Metal containment (outer pressure vessel) has the similar features to LTNHR-200 pressure vessel. There exists no LOCA and core melting with the double vessel. The in-service inspection of the pressure vessel can be simplified greatly because of the safety and structural features of the reactor.

  17. 对田径200米运动项目特点的分析

    Institute of Scientific and Technical Information of China (English)

    邹昕宇

    2014-01-01

    200米跑是田径短距离运动中技术特点较为突出的一个项目。200米运动项目自1900年第2届奥运会开始至今已经有一百多年的历史了。文章从介绍200米跑运动项目的起源谈起,探讨了200米跑运动项目成绩的发展过程;最后对200米跑的供能特点进行分析。

  18. MiR-200c promotes bladder cancer cell migration and invasion by directly targeting RECK

    Directory of Open Access Journals (Sweden)

    Cheng Y

    2016-08-01

    Full Text Available Yidong Cheng,* Xiaolei Zhang,* Peng Li,* Chengdi Yang, Jinyuan Tang, Xiaheng Deng, Xiao Yang, Jun Tao, Qiang Lu, Pengchao Li Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China *These authors contributed equally to this work Background: Increasing evidence suggests that the dysregulation of certain microRNAs plays an important role in tumorigenesis and metastasis. MiR-200c exhibits a disordered expression in many tumors and presents dual roles in bladder cancer (BC. Therefore, the definite role of miR-200c in BC needs to be investigated further.Materials and methods: Quantitative reverse transcription polymerase chain reaction was used to assess miR-200c expression. Cell invasion and migration were evaluated using wound healing and transwell assays. The luciferase reporter assay was used to identify the direct target of miR-200c. The expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK in BC tissues and adjacent nontumor tissues, as well as in BC cell lines, was detected through quantitative reverse transcription polymerase chain reaction, Western blot assay, and immunohistochemistry.Results: The miR-200c expression was significantly upregulated in the BC tissues compared with the adjacent nontumor tissues. The downregulation of miR-200c significantly inhibited cell migration and invasion in the BC cell lines. The luciferase reporter assay showed that RECK was a direct target of miR-200c. The knockdown of RECK in the BC cell lines treated with anti-miR-200c elevated the previously attenuated cell migration and invasion.Conclusion: Our findings indicated that miR-200c functions as oncogenes in BC and may provide a novel therapeutic strategy for the treatment of BC. Keywords: miR-200c, bladder cancer, migration, invasion, RECK

  19. Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer

    DEFF Research Database (Denmark)

    Wiklund, Erik D; Bramsen, Jesper B; Hulf, Toby

    2011-01-01

    MicroRNAs (miRNA) are small noncoding RNAs commonly deregulated in cancer. The miR-200 family (miR-200a, -200b, -200c, -141 and -429) and miR-205 are frequently silenced in advanced cancer and have been implicated in epithelial to mesenchymal transition (EMT) and tumor invasion by targeting the t...

  20. Regulation of miR-200c by Nuclear Receptors PPARα, LRH-1 and SHP

    Science.gov (United States)

    Zhang, Yuxia; Yang, Zhihong; Whitby, Richard; Wang, Li

    2011-01-01

    We investigated regulation of miR-200c expression by nuclear receptors. Ectopic expression of miR-200c inhibited MHCC97H cell migration, which was abrogated by the synergistic effects of PPARα and LRH-1 siRNAs. The expression of miR-200c was decreased by PPARα/LRH-1 siRNAs and increased by SHP siRNAs, and overexpression of the receptors reversed the effects of their respective siRNAs. SHP siRNAs also drastically enhanced the ability of the LRH-1 agonist RJW100 to induce miR-200c and downregulate ZEB1 and ZEB2 proteins. Co-expression of PPARα and LRH-1 moderately transactivated the miR-200c promoter, which was repressed by SHP co-expression. RJW100 caused strong activation of the miR-200c promoter. This is the first report to demonstrate that miR-200c expression is controlled by nuclear receptors. PMID:22100809

  1. BAF200 is required for heart morphogenesis and coronary artery development.

    Directory of Open Access Journals (Sweden)

    Lingjuan He

    Full Text Available ATP-dependent SWI/SNF chromatin remodeling complexes utilize ATP hydrolysis to non-covalently change nucleosome-DNA interactions and are essential in stem cell development, organogenesis, and tumorigenesis. Biochemical studies show that SWI/SNF in mammalian cells can be divided into two subcomplexes BAF and PBAF based on the subunit composition. ARID2 or BAF200 has been defined as an intrinsic subunit of PBAF complex. However, the function of BAF200 in vivo is not clear. To dissect the possible role of BAF200 in regulating embryogenesis and organ development, we generated BAF200 mutant mice and found they were embryonic lethal. BAF200 mutant embryos exhibited multiple cardiac defects including thin myocardium, ventricular septum defect, common atrioventricular valve, and double outlet right ventricle around E14.5. Moreover, we also detected reduced intramyocardial coronary arteries in BAF200 mutants, suggesting that BAF200 is required for proper migration and differentiation of subepicardial venous cells into arterial endothelial cells. Our work revealed that PBAF complex plays a critical role in heart morphogenesis and coronary artery angiogenesis.

  2. microRNA-200a silencing protects neural stem cells against cerebral ischemia/reperfusion injury

    Science.gov (United States)

    Ma, Ji; Shui, Shaofeng; Han, Xinwei; Guo, Dong; Li, Tengfei; Yan, Lei

    2017-01-01

    Neural stem cells (NSCs) play major roles in neurological recovery after cerebral infarction (CI). This study was trying to investigate whether miR-200a, a vital regulator in cell proliferation, migration and apoptosis, also has a role in oxygen-glucose deprivation/reperfusion (OGD/R) injured NSCs. In this study, primary NSCs were subjected to OGD/R conditions to mimic an in vitro CI model. Before OGD/R induction, NSCs were transfected with vector or shRNA against miR-200a to overexpress or suppress miR-200a expression. The changes in cell viability, apoptosis, migration, the expression of c-Myc, and the phosphorylation of STAT1, STAT3 and MAPK were respectively assessed. Inhibitors of STAT1/3 and MAPK, i.e., Nifuroxazide and BIRB 796, were used to administrate miR-200a-silenced NSCs, and the expressions of above mentioned proteins were detected. After OGD/R exposure, miR-200a was up-regulated in NSCs (P < 0.001). miR-200a silencing alleviated OGD/R-induced the decrease of cell viability and migration (P < 0.01); meanwhile, alleviated OGD/R-induced apoptosis via reducing Bax/Bcl-2 ratio and down-regulating p53 and cytochrome c (P < 0.01 or P < 0.001). c-Myc, p-STAT1, p-STAT3, p-MAPK were all negatively regulated by miR-200a (P < 0.01 or P < 0.001); more important, the increase of c-Myc induced by miR-200a silencing was abolished by Nifuroxazide or BIRB 796 (P < 0.01 or P < 0.001). These data indicate miR-200a silencing protects NSCs from OGD/R-induced injury, possibly via regulating the STATs/c-Myc and MAPK/c-Myc signalings. PMID:28222148

  3. A damage model of Zr {alpha} under cyclic loading at 200 degree Celsius; Modelisation de l`endommagement du Zr {alpha} sous chargement cyclique a 200 deg C

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, C.; Drubay, B. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. de Mecanique et de Technologie; Cailletaud, G. [Ecole Nationale Superieure des Mines, 75 - Paris (France); Mottot, M. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Direction des Technologies Avancees

    1994-12-31

    A damage model for anticipating zirconium {alpha} test-piece rupture under cyclic solicitations at 200 degree Celsius is presented. The article is divided into three parts : an experimental approach, the damage model presentation and the application of this model. (O.L.). 10 refs., 7 figs., 4 tabs.

  4. EFFICACY OF IMIDACLOPRID (CONFIDOR 200 SL AGAINST APHIDS INFESTING WHEAT CROP

    Directory of Open Access Journals (Sweden)

    N Joshi

    2010-02-01

    Full Text Available Imidacloprid (Confidor 200 SL was evaluated either alone or with a fungicide (Tilt 0.01% against wheat aphids. There were seven different treatments, including an untreated control. All the treatments were replicated three times in a similar field environment. Population of wheat aphids was recorded on randomly selected five plants in each plot at different intervals, both before and after the spraying. Confidor 200 SL @ 400 ml/ha treatment was found most effective against wheat aphids. However, mixing of Confidor 200 SL @ 100 ml/ha with Tilt @ 0.01 %, was found significantly least effective for wheat aphids control.

  5. 从F200谈富士新一代Super CCD EXR

    Institute of Scientific and Technical Information of China (English)

    落单的鱼

    2009-01-01

    富士的F系列消费类相机是其主打“优秀成像”概念的系列相机.而FinePix F200EXR是F系列相机的最新旗舰型号。但是光看配置.F200和F100似乎没有什么变化.那么F200较F100到底有哪些改进之处呢?

  6. WinCC与S7-200系列PLC通信的实现

    Institute of Scientific and Technical Information of China (English)

    孙连生; 刘志韬

    2006-01-01

    针对控制系统中上位机与S7—200系列PLC(Program Logic Control)通信的实际问题.总结了使用WinCC组态软件上位机与S7—200系列PLC的通信方法,这几种方法在不同的控制系统中能较好解决上位机与S7~200系列PLC通信问题。

  7. 眩晕200例中医治疗临床研究%Research on TCM Treatment of 200 Cases of Patients with Vertigo

    Institute of Scientific and Technical Information of China (English)

    王金桥

    2014-01-01

    Objective To study the clinical ef ect of vertigo, 200 cases of traditional Chinese medicine treatment.Methods April 2012~January 2014 to our hospital for treatment of vertigo patients 200 cases, according to the patient's symptoms observation analysis, compare the therapeutic ef ect of patients before and after treatment of traditional Chinese medicine. Results A total of 200 patients with vertigo were in the process of Chinese medicine treatment, the clinical ef ect of 185 cases were markedly improved, ef ective in 13 cases, not only in 2 cases, total ef ective rate is 99.0%. Conclusion Take the traditional Chinese medicine treatment in patients with vertigo at ack number of times and the symptom such as dizziness, blur ed vision has significant ef ect, worthy of clinical application and promotion.%目的研究眩晕200例中医治疗的临床效果。方法选取2012年4月~2014年1月来我院进行治疗眩晕的患者200例,根据患者的病状进行观察分析,比较患者中医治疗前后的治疗效果。结果对我院的200例眩晕患者进行中医治疗的过程中,临床效果显效的有185例,有效的有13例,无效的只有2例,总有效率达到99.0%。结论采取中医治疗对眩晕患者的发作次数和头昏眼花、视力模糊等症状具有显著的效果,值得临床运用及推广。

  8. Therapeutic evaluation of homoeopathic drug Crotalus horridus 200C against Ehrlichiosis-infected dogs in Mizoram

    Directory of Open Access Journals (Sweden)

    Isaac B Tungnunga

    2016-01-01

    Conclusion: Nested PCR assay had been shown to be sensitive and specific for detection of Ehrlichia canis. Crotalus horridus 200C may be an effective and choice of drug for control of canine ehrlichiosis.

  9. 17 CFR 200.60 - Qualification to participate in particular matters.

    Science.gov (United States)

    2010-04-01

    ... EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200... respect to any matter wherein he or any relatives or former business associates or clients are...

  10. Doctor Offices, Published in 2008, 1:2400 (1in=200ft) scale, Shawano County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Doctor Offices dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Published Reports/Deeds information as of 2008. Data by this...

  11. Address Points, Published in 2008, 1:2400 (1in=200ft) scale, Eau Claire County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Address Points dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Other information as of 2008. Data by this publisher are often...

  12. Õpetajaks hakkamise eest võib tulevikus saada 200 000 krooni / Mirko Ojakivi

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2007-01-01

    Isamaa ja Res Publica Liit lubab võimule pääsedes maksta esmakordselt tööle asuvale pedagoogilise kõrgharidusega õpetajale 200 000 krooni stardiraha. Endise haridusministri Tõnis Lukase selgitus

  13. 33 CFR 166.200 - Shipping safety fairways and anchorage areas, Gulf of Mexico.

    Science.gov (United States)

    2010-07-01

    ... Navigation or danger markings must be installed as required by 33 CFR Subchapter C. (c) Special Conditions...: For Federal Register citations affecting § 166.200, see the List of CFR Sections Affected,...

  14. Color Alaska Shaded Relief ? 200-Meter Resolution, Albers projection - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The NED is...

  15. 康斯登肖邦200周年腕表限量1810枚

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    康斯登(Frederique Constant)在去年向钢琴大师肖邦200周年冥诞致敬,推出了"肖邦200周年纪念表",今年再次推出"肖邦200周年纪念表",表盘改以优雅的珐琅材质呈现,整体更显古典气息。全球限量1810只。今年全新的"肖邦(Chopin)200周年纪念表"珐琅材质表盘款式,以2010年的版本为基础,在表盘上使用了白色珐琅打造,

  16. Haridusministeerium kingib koolilõpetajatele 200 000 eest šokolaadi / Mirko Ojakivi

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2006-01-01

    Haridus- ja Teadusministeerium kingib keskkoolide, gümnaasiumide ja kutsekoolide lõpetajatele 200 000 krooni eest Kalevi erikujundusega šokolaadi. Seda otsust kritiseerib endine haridusminister Tõnis Lukas

  17. USGS Small-scale Dataset - Color Hawaii Shaded Relief - 200-Meter Resolution 200512 GeoTIFF

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The NED is...

  18. The VASIMR[registered trademark] VF-200-1 ISS Experiment as a Laboratory for Astrophysics

    Science.gov (United States)

    Glover Tim W.; Squire, Jared P.; Longmier, Benjamin; Cassady, Leonard; Ilin, Andrew; Carter, Mark; Olsen, Chris S.; McCaskill, Greg; Diaz, Franklin Chang; Girimaji, Sharath; Araya, Daniel; Shebalin, John

    2010-01-01

    The VASIMR[R] Flight Experiment (VF-200-1) will be tested in space aboard the International Space Station (ISS) in about four years. It will consist of two 100 kW parallel plasma engines with opposite magnetic dipoles, resulting in a near zero-torque magnetic system. Electrical energy will come from ISS at low power level, be stored in batteries and used to fire the engine at 200 kW. The VF-200-1 project will provide a unique opportunity on the ISS National Laboratory for astrophysicists and space physicists to study the dynamic evolution of an expanding and reconnecting plasma loop. Here, we review the status of the project and discuss our current plans for computational modeling and in situ observation of a dynamic plasma loop on an experimental platform in low-Earth orbit. The VF-200-1 project is still in the early stages of development and we welcome new collaborators.

  19. Address Points, Published in 2008, 1:2400 (1in=200ft) scale, Kenosha County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Address Points dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Other information as of 2008. Data by this publisher are often...

  20. 小鼠体型控制相关microRNA-200b(miR-200b)的表达谱及靶标分析%The Expression Profile and Target Gene Analysis of Mouse (Mus musculus) Body Size Regulation related microRNA-200b(miR-200b)

    Institute of Scientific and Technical Information of China (English)

    任红艳; 刘楠; 陶聪; 郑建伟; 李奎

    2013-01-01

    microRNA-200b (miR-200b) has similar functions in regulating body size in mammals, while its exact roles has not been examined in mammals. To study the expression of miR-200b during the embryo development stage, and investigate the important roles of miR-200b and its target gene in regulating the body size of mouse, in this study, precursor miR-200b was amplified from the mouse (Mus musculus) genome DNA, RNA folding sofware was used to construct the secondary structure of miR-200b; potential target genes were predicted with bioinformatic software, and validated through Dual-luciferase reporter assay system; the expression profiles of miR-200b and its target gene Fog2 were detected using Real-time PCR in different tissues of adult mouse and embryos at the stage of 10.5~15.0 days after coitus. The results showed that the miR-200b precursor had the typical stem-loop structure of microRNA, and the Fog2 gene was predicted and tested to be a target gene of miR-200b, which showed negatively related expression to miR-200b in the embryos dpc10. 5~15.0; qRT-PCR results showed that the miR-200b was expressed in almost all the tissues of female mouse, with higher expression in muscle, kidney and uterine, and lower expression in heart, spleen and lung tissues. From the expression profile and target gene testing results, we can conclude that miR-200b may play important roles in regulating mouse embryo development through acting with its target gene Fog2.%microRNA-200b(miR-200b)具有类似的调控哺乳动物体型大小的功能,但尚未在哺乳动物个体上进行验证.为研究microRNA-200b在小鼠发育过程中的表达,探讨microRNA-200b及其靶标基因在小鼠体型发育调控中的关键作用,本研究从小鼠(Mus musculus)基因组中扩增得到miR-200b前体序列,并验证了该miRNA的茎环前体结构;采用生物信息学软件预测miR-200b可能的靶基因,并通过双荧光素酶报告载体系统验证了miR-200b与靶基因3'UTR

  1. Tourism Areas, Published in 2011, 1:2400 (1in=200ft) scale, Trempealeau County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Tourism Areas dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2011. Data by this publisher are...

  2. USGS Small-scale Dataset - Grayscale Hawaii Shaded Relief - 200-Meter Resolution 200509 GeoTIFF

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The...

  3. USGS Small-scale Dataset - Grayscale Alaska Shaded Relief - 200-Meter Resolution 200509 GeoTIFF

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The...

  4. USGS Small-scale Dataset - Color Alaska Shaded Relief - 200-Meter Resolution 200512 GeoTIFF

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The NED is...

  5. Color Hawaii Shaded Relief ? 200-Meter Resolution, Albers projection - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The NED is...

  6. Grayscale Alaska Shaded Relief ? 200-Meter Resolution, Albers projection - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The...

  7. Grayscale Hawaii Shaded Relief ? 200-Meter Resolution, Albers projection - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The...

  8. Summary of radioactive solid waste received in the 200 Areas during calendar year 1995

    Energy Technology Data Exchange (ETDEWEB)

    Hladek, K.L.

    1996-06-06

    Westinghouse Hanford Company manages and operates the Hanford Site 200 Area radioactive solid waste storage and disposal facilities for the US Department of Energy, Richland Operations Office. These facilities include radioactive solid waste disposal sites and radioactive solid waste storage areas. This document summarizes the amount of radioactive materials that have been buried and stored in the 200 Area radioactive solid waste storage and disposal facilities since startup in 1944 through calendar year 1995. This report does not include backlog waste, solid radioactive wastes in storage or disposed of in other areas, or facilities such as the underground tank farms. Unless packaged within the scope of WHC-EP-0063, Hanford Site Solid Waste Acceptance Criteria, liquid waste data are not included in this document. This annual report provides a summary of the radioactive solid waste received in the both the 200-East and 200-West Areas during the calendar year 1995.

  9. 76 FR 24351 - Airworthiness Directives; Airbus Model A340-200 and -300 Series Airplanes

    Science.gov (United States)

    2011-05-02

    ... economic impact, positive or negative, on a substantial number of small entities under the criteria of the... A340-200/-300 pre- modification 49203 (reinforcements of pylon primary structure for enhanced...

  10. Pharmacy Locations, Published in 2008, 1:2400 (1in=200ft) scale, Shawano County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Pharmacy Locations dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Published Reports/Deeds information as of 2008. Data by this...

  11. Assisted Living Facilities, Published in 2010, 1:2400 (1in=200ft) scale, Shawano County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Assisted Living Facilities dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Published Reports/Deeds information as of 2010. Data...

  12. Ambulatory Surgical Facilities, Published in 2010, 1:2400 (1in=200ft) scale, Shawano County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Ambulatory Surgical Facilities dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Published Reports/Deeds information as of 2010....

  13. Emergency Shelters, Published in 2007, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Emergency Shelters dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2007. Data by this publisher...

  14. Fire Stations, Published in 2007, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Fire Stations dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2007. Data by this publisher are...

  15. Navigable Waters, Published in 2007, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Navigable Waters dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2007. Data by this publisher...

  16. Public Beaches, Published in 2008, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Public Beaches dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2008. Data by this publisher are...

  17. Navigable Waters, Published in 1996, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Navigable Waters dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 1996. Data by this publisher...

  18. Trails, Hiking, Published in 2007, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, Hiking dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2007. Data by this publisher are...

  19. Fair Grounds, Published in 2007, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Fair Grounds dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2007. Data by this publisher are...

  20. Trails, Bike, Published in 2007, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Trails, Bike dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2007. Data by this publisher are...

  1. Dam Inventory, Published in 2007, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Dam Inventory dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2007. Data by this publisher are...

  2. Railroad Lines, Published in 2007, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Railroad Lines dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2007. Data by this publisher are...

  3. Police Stations, Published in 2007, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Police Stations dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2007. Data by this publisher...

  4. Cultural Resources, landmarks, Published in 2008, 1:2400 (1in=200ft) scale, Haskell County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Cultural Resources dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Not Provided information as of 2008. It is described as...

  5. Zoning Districts, Published in 2012, 1:2400 (1in=200ft) scale, Sauk County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Zoning Districts dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Published Reports/Deeds information as of 2012. Data by this...

  6. Hydrography, Published in 2008, 1:2400 (1in=200ft) scale, Harper County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Hydrography dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Not Provided information as of 2008. Data by this publisher are...

  7. Easements, Published in 2008, 1:2400 (1in=200ft) scale, Harper County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Easements dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Not Provided information as of 2008. Data by this publisher are often...

  8. Soils, Published in 2008, 1:2400 (1in=200ft) scale, Harper County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Soils dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Not Provided information as of 2008. Data by this publisher are often...

  9. The novel fluid loss additive HTF-200C for oil field cementing%新型固井降失水剂HTF-200C

    Institute of Scientific and Technical Information of China (English)

    郭锦棠; 卢海川; 刘硕琼; 靳建州; 于永金

    2012-01-01

    The domestic fluid loss additives often have lower thermal stability and poor salt-tolerance and their comprehensive properties are not good enough. To solve the problems, a novel cement fluid loss additive HTF-200C. Which can resist high temperature and high salt content, was synthesized using the monomers of 2-acrylamido-2-methyl-propane sulphonic acid (AMPS), N, N-dimethyl acrylamide (DMAA) and a new compound with double carboxyl by the method of aqueous solution polymerization. The microstructural characterization and application performance of HTF-200C show that the polymer with the structure of all the monomers has an excellent thermal stability and strong salt tolerance, and can be used in 200 "C or in saturated brine. And the problem of the normal fluid loss additive being easy to hydrolyze due to high temperature can be solved with HTF-200C. What's more, it can also deal with the bulge of thickening curve in consistency test. The cement slurry prepared mainly by HTF-200C presents good comprehensive properties such as low filtration, high thermal stability, strong salt tolerance, rapid development of strength in low temperature, without far delayed solidification, short transit time during thickening process, and so on. The cementing job quality of Well Chengu 1-3 in the Liaohe Oilfield is excellent after it is used.%针对目前中国常规固井降失水剂抗温抗盐能力差、综合性能欠佳的问题,以2-丙烯酰胺基-2-甲基丙磺酸(AMPS)、N,N-二甲基丙烯酰胺(DMAA)、新型双羧基化合物为单体,采用水溶液自由基聚合的方法合成了耐盐、抗高温的共聚物型固井水泥降失水剂HTF-200C.HTF-200C微观结构表征和应用性能综合评价表明,各单体成功参与聚合,共聚物热稳定性良好;该降失水剂控失水耐温可达200℃,抗盐达饱和,可解决常规降失水剂高温下易水解、稠化实验“鼓包”等问题;以HTF-200C为主剂的水泥浆体系失水量低、抗盐耐温

  10. Annex D-200 Area Interim Storage Area Final Safety Analysis Report [FSAR] [Section 1 & 2

    Energy Technology Data Exchange (ETDEWEB)

    CARRELL, R D

    2002-07-16

    The 200 Area Interim Storage Area (200 Area ISA) at the Hanford Site provides for the interim storage of non-defense reactor spent nuclear fuel (SNF) housed in aboveground dry cask storage systems. The 200 Area ISA is a relatively simple facility consisting of a boundary fence with gates, perimeter lighting, and concrete and gravel pads on which to place the dry storage casks. The fence supports safeguards and security and establishes a radiation protection buffer zone. The 200 Area ISA is nominally 200,000 ft{sup 2} and is located west of the Canister Storage Building (CSB). Interim storage at the 200 Area ISA is intended for a period of up to 40 years until the materials are shipped off-site to a disposal facility. This Final Safety Analysis Report (FSAR) does not address removal from storage or shipment from the 200 Area ISA. Three different SNF types contained in three different dry cask storage systems are to be stored at the 200 Area ISA, as follows: (1) Fast Flux Test Facility Fuel--Fifty-three interim storage casks (ISC), each holding a core component container (CCC), will be used to store the Fast Flux Test Facility (FFTF) SNF currently in the 400 Area. (2) Neutron Radiography Facility (NRF) TRIGA'--One Rad-Vault' container will store two DOT-6M3 containers and six NRF TRIGA casks currently stored in the 400 Area. (3) Commercial Light Water Reactor Fuel--Six International Standards Organization (ISO) containers, each holding a NAC-I cask4 with an inner commercial light water reactor (LWR) canister, will be used for commercial LWR SNF from the 300 Area. An aboveground dry cask storage location is necessary for the spent fuel because the current storage facilities are being shut down and deactivated. The spent fuel is being transferred to interim storage because there is no permanent repository storage currently available.

  11. Strangeness production in p+Pb reactions at 200 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Greiner, D.E. [Lawrence Berkeley Lab. (LBL), CA (United States); Andersen, E.; Blaes, R.; Cherney, M.; Cruz, B. de la; Fernandez, C.; Garabatos, C.; Garzon, J.A.; Geist, W.M.; Gruhn, C.R.; Hafidouni, M.; Hrubec, J.; Jones, P.G.; Judd, E.G.; Kuipers, J.P.M.; Ladrem, M.; Ladron de Guevara, P.; Loevhoeiden, G.; MacNaughton, J.; Mosquera, J.; Natkaniec, Z.; Nelson, J.M.; Neuhofer, G.; Perez de los Heros, C.; Plo, M.; Porth, P.; Powell, B.; Ramil, A.; Rohringer, H.; Sakrejda, I.; Thorsteinsen, T.F.; Traxler, J.; Voltolini, C.; Wozniak, K.; Yanez, A.; Zybert, R. [Fysisk Institutt, Bergen Univ. (Norway)]|[Centre de Recherches Nucleaires, IN2P3-CNRS/Univ. L. Pasteur, 67 -Strasbourg (France)]|[Creighton Univ., Dept. of Physics, Omaha, NE (United States)]|[CIEMAT, Div. de Fisica de Particulas, Madrid (Spain)]|[Universidad de Santiago de Compostela (Spain). Dept. de Fisica de Particulas]|[Lawrence Berkeley Lab. (LBL), CA (United States)]|[Inst. fuer Hochenergiephysik (HEPHY), Vienna (Austria)]|[Dept. of Physics, Birmingham Univ. (United Kingdom)]|[CERN, Geneva (Switzerland)]|[Instytut Fizyki Jadrowej, Krakow (Poland); NA36 Collaboration

    1994-01-03

    The production of the strange particles {Lambda}, anti {Lambda} and K{sub S}{sup 0} in p+Pb collisions at 200 GeV/c has been measured using the NA36 TPC. Rapidity distributions and multiplicity dependences are presented and compared to model calculations. Reinteractions in the target are important to describe the observed spectra. Inverse slopes T{approx}200 MeV are extracted from the transverse mass distributions. (orig.)

  12. In situ Measurements of the SPS 200MHz Accelerating Cavity III

    CERN Document Server

    Kramer, Patrick; Caspers, Fritz; Vollinger, Christine; Montesinos, Eric; CERN. Geneva. ATS Department

    2015-01-01

    The main 200MHz travelling wave RF system of the SPS consists of two 5-tank and two 4-tank cavities. This system will be modified during LS 2, and the preparation work has already started. The 5 tank 200MHz travelling wave cavity III was measured in reflection. This Internal Note presents results obtained for the matching of cavity and feeder line, by looking at both frequency and time domain data. Techniques for estimating the feeder line attenuation are also presented.

  13. Discrete Sampling Test Plan for the 200-BP-5 Operable Unit

    Energy Technology Data Exchange (ETDEWEB)

    Sweeney, Mark D.

    2010-02-04

    The Discrete Groundwater Sampling Project is conducted by the Pacific Northwest National Laboratory (PNNL) on behalf of CH2M HILL Plateau Remediation Company. The project is focused on delivering groundwater samples from proscribed horizons within select groundwater wells residing in the 200-BP-5 Operable Unit (200-BP-5 OU) on the Hanford Site. This document provides the scope, schedule, methodology, and other details of the PNNL discrete sampling effort.

  14. A Comprehensive Review on miR-200c, A Promising Cancer Biomarker with Therapeutic Potential.

    Science.gov (United States)

    Kumar, Suresh; Nag, Alo; Mandal, Chandi C

    2015-01-01

    MicroRNAs (miRNAs) are small single stranded non coding RNA molecules (~22 nucleotides) which impede protein production by directly interacting with 3'untranslated regions of the target mRNAs. Interestingly, miR-200c is often dysregulated in various cancers that normally exhibits tumor suppressive behavior by blocking epithelial to mesenchymal transition (EMT) of cancer cells. However, elevation of miR-200c in various cancer tissues contradicts the tumor suppressive role of this microRNA. This review addresses the molecular mechanisms involved in the regulation of the endogenous level of miR-200c in various cancers such as breast, ovarian, prostate, endometrial, lungs, colon, pancreatic, etc. and its differential role in regulation of proliferation and EMT phenotype of cancer cells. Further, this review discusses whether abnormal level of miR-200c in cancer tissues or in blood circulation can be used as a biomarker. Importantly, how the level of miR-200c can be used to predict the effectiveness of the cancer therapy is also discussed. Accumulating evidences suggest that use of miR-200c alone may not be sufficient for treatment of cancer patients, but the combination of miR-200c with an anti-proliferating drug could be a better choice to prevent invasiveness of cancers as well as tumor growth both in primary and in metastatic sites. This article also proposes that the tumor microenvironment may have a role in influencing epigenetic silencing of miR-200c expression.

  15. Epithelial cell differentiation regulated by MicroRNA-200a in mammary glands.

    Directory of Open Access Journals (Sweden)

    Kentaro Nagaoka

    Full Text Available Mammary gland epithelial cells undergo periodic cycles of proliferation, differentiation, and involution. Many studies have reported that miRNAs, which are small, non-coding RNAs, influence a variety of biological processes during posttranscriptional regulation. Here, we found that one miRNA, miR-200a, was relatively highly expressed in epithelial cell-rich organs such as mammary glands, lung, and kidney in mice. In mammary glands, miR-200a expression increased during mid-pregnancy through lactation; its expression was stimulated by lactogenic hormone treatment of mammary epithelial cells. Lactogenic hormone also induced the expression of milk protein ß-casein mRNA (a marker of cell differentiation and E-cadherin mRNA (a marker of epithelial cells. However, knockdown of miR-200a prevented increases in ß-casein and E-cadherin mRNA expression. Protein analysis revealed that E-cadherin signal was decreased and ZEB1 (a marker of EMT was increased following miR-200a knockdown. Finally, in a three-dimensional culture system modeling lumen-containing mammary ducts, miR-200a knockdown decreased the cavity formation rate and suppressed claudin-3 and par-6b expression, indicating reduced epithelial cell polarity. These observations suggest that miR-200a is important for maintaining the epithelial cell phenotype, which contributes to lactogenic hormone induction of cellular differentiation in mammary glands.

  16. miR-200家族在乳腺癌中的表达及其临床意义%The expression and its clinical significance of miR-200 family members in breast cancer

    Institute of Scientific and Technical Information of China (English)

    杨平安; 邢程; 王如娟

    2016-01-01

    目的 探讨miR-200家族成员在乳腺癌中的表达及其临床意义.方法 实时定量PCR和原位杂交分析乳腺癌组织中miR-200家族5个成员的表达情况.单因素和多因素分析miR-200a、miR-200b和miR-200c表达与乳腺癌临床病理参数和预后之间的相关性.结果 miR-200a、miR-200b和miR-200c在乳腺癌组织中的表达明显低于正常乳腺上皮组织,差异有统计学意义(P<0.01).miR-200a和miR-200b低表达与乳腺癌分期更晚、分级更高有关,而miR-200e低表达仅与分期更晚有关.多元回归分析表明,miR-200a、miR-200b和miR-200c低表达与乳腺癌患者生存期更短有关(P<0.01),miR-200a、miR-200b和miR-200c是乳腺癌患者预后的独立预测因子.结论 miR-200a、miR-200b和miR-200e表达下调能够促进肿瘤进展,是预测乳腺癌患者预后的可靠指标,miR-200a、miR-200b和miR-200c也具有成为乳腺癌靶向治疗靶点的潜力.

  17. Production process for 200kt/a heavy soda with low-salt%200kt/a低盐重质纯碱生产工艺

    Institute of Scientific and Technical Information of China (English)

    李清菊; 李振宁

    2001-01-01

    介绍了200kt/a“固体进料离心分离一水碱法”低盐重质纯碱的生产工艺及其特点,并对该装置主要设备与控制要点进行了分析。原料一水碱水分含量要求为18%~22%,成品盐份控制在0.3%以下。%The production process and characteristics of 200kt/a heavy soda with low-salt by solid feeding and centrifuge separation of monhydrate soda were introduced, and the main equipment and controlling main point of the installation were analysed. Water content of material monohydrate soda was 18%~19%,and salt content of product was controlled to lower than 0.3%.

  18. Omron c200h-plc program design and application%欧姆龙C200 H型PLC编程设计精讲实例

    Institute of Scientific and Technical Information of China (English)

    高永斌

    2014-01-01

    The article introduces the feature of the Omron C200H-PLC,analyses some typical circuits,gives the I/O allocation table,draws the wiring diagram,designs the ladder diagrams that meet the control requirement, summarizes three kinds of PLC programmed design methods.%介绍了欧姆龙(OMRON)C200H_PLC 的性能特点,通过几个典型电路的分析,列出 I/O 分配表、画出接线图,设计出符合控制要求的梯形图,总结出3种 PLC 程序的设计方法。

  19. XHX200型X光机结构分析及保养技巧%On the Structure and Maintenance of XHX200 X-ray Machine

    Institute of Scientific and Technical Information of China (English)

    张日文

    2015-01-01

    本文系统分析了X H X200型医用X光机的实际结构,并根据多年工作经验从安装、使用及清洁等环节提出有利于设备安全运行和使用寿命延长的保养技巧。%This paper analyzed the actual structure of XHX200 medical X-ray machine systematicaly. Based on the working experience of many years, the author also put forward some maintenance tips during instalation, use and cleaning, which can facilitate the machine’s safe operation and life extension.

  20. 电切法袖套式包皮环切术200例临床分析%Electric cutting sleeve circumcision : clinical analysis of 200 cases

    Institute of Scientific and Technical Information of China (English)

    邹义华; 陈晓峰; 陈善群

    2012-01-01

    Objective:To evaluate the safety and effect of electric cutting sleeve circumcision for treatment of patients with redundant prepuce and phimosis. Method: Using electric cutting sleeve circumcision in 200 cases, the curative effect, complications and their prevention measures were analyzed. Result:The 200 cases of electric cutting sleeve circumcision show little bleeding, neat cutting, slight postoperative wound edema, little scar and satisfactory appearance of penis. Conclusion: With more satisfactory curative effect and fewer complications, Electric sleeve circumcision for treatment of patients with redundant prepuce and phimosis is worthy of clinical application.%目的:探讨电切法袖套式包皮环切术治疗包皮过长与包茎患者的安全性与疗效.方法:采用电切法袖套式包皮环切术治疗包皮过长与包茎患者200例,分析手术效果、并发症及其预防措施.结果:200例电切法袖套式包皮环切术出血少、切缘整齐,术后包皮水肿轻微,切口均一期愈合,癜痕少,阴茎外观满意.结论:电切法袖套式包皮环切术治疗包皮过长与包茎患者效果满意,并发症少,值得临床推广.

  1. Clinical Analysis on Improved New Cesarean Section in 200 Cases%改良的新式剖宫产术200例临床分析

    Institute of Scientific and Technical Information of China (English)

    徐丽

    2013-01-01

    Objective To discuss the clinical effect of improved new cesarean section .Method Various clinical indicators of 200 cases treated with improved new cesarean section and 200 cases treated with the traditional cesarean section were observed and compared .Results The time duration of operation,volume of blood loss, time of fetal delivery,incision pain,discharge of the mother after the operation ,wound healing,and hospitalization days all were improved in patients in the improved group ,and the differences between the two groups were significantly different ( P <0.05).Conclusion The improved new cesarean section is desirable in clinical application and can replace the traditional cesarean section in clinic .%  目的探讨改良的新式剖宫产术临床效果.方法观察对照200例改良的新式剖宫产术与同期200例传统剖宫产术的多项指标.结果改良的新式剖宫产术所需手术时间短,术中出血少,胎儿娩出时间短,术后排气快,术后切口疼痛轻,切口愈合良好,住院天数少.两组比较有统计学意义(P<0.05).结论改良的新式剖宫产术具有较好的临床价值,可以替代传统的剖宫产术.

  2. Study on 1 200 kW Radio Tube High Frequency Welding Unit%1 200 kW电子管高频焊机的研制

    Institute of Scientific and Technical Information of China (English)

    彭咏龙; 夏越良; 轩维克

    2004-01-01

    介绍了1 200 kW电子管高频焊机的系统组成,并对其主要设计参数和自动控制系统做了简要说明,重点介绍了超蒸发冷却技术在电子管高频设备中的应用,探讨了提高焊接效率的几项措施.

  3. FEASIBILITY STUDY REPORT FOR THE 200-ZP-1 GROUNDWATER OPERABLE UNIT

    Energy Technology Data Exchange (ETDEWEB)

    BYRNES ME

    2008-07-18

    The Hanford Site, managed by the U.S. Department of Energy (DOE), encompasses approximately 1,517 km{sup 2} (586 mi{sup 2}) in the Columbia Basin of south-central Washington State. In 1989, the U.S. Environmental Protection Agency (EPA) placed the 100, 200, 300, and 1100 Areas of the Hanford Site on the 40 Code of Federal Regulations (CFR) 300, 'National Oil and Hazardous Substances Pollution Contingency Plan' National Contingency Plan [NCPD], Appendix B, 'National Priorities List' (NPL), pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The 200 Areas NPL sites consist of the 200 West and 200 East Areas (Figure 1-1). The 200 Areas contain waste management facilities, inactive irradiated fuel reprocessing facilities, and the 200 North Area (formerly used for interim storage and staging of irradiated fuel). Several waste sites in the 600 Area, located near the 200 Areas, also are included in the 200 Areas NPL site. The 200 Areas NPL site is in a region referred to as the 'Central Plateau' and consists of approximately 700 waste sites, excluding sites assigned to the tank farm waste management areas (WMAs). The 200-ZP-1 Groundwater Operable Unit (OU) consists of the groundwater located under the northern portion of the 200 West Area. Waste sources that contributed to the 200-ZP-1 OU included cribs and trenches that received liquid and/or solid waste in the past from the Z Plant and T Plant aggregate areas, WMA-T, WMA-TX/TY, and the State-Approved Land Disposal Site (SALDS). This feasibility study (FS) for the 200-ZP-1 Groundwater OU was prepared in accordance with the requirements of CERCLA decision documents. These decision documents are part of the Administrative Record for the selection of remedial actions for each waste site and present the selected remedial actions that are chosen in accordance with CERCLA, as amended by the Superfund Amendments and Reauthorization Act of 1986

  4. Circulating microRNA-200 Family as Diagnostic Marker in Hepatocellular Carcinoma.

    Directory of Open Access Journals (Sweden)

    Sameer A Dhayat

    Full Text Available In this clinical study, we aimed to evaluate the role of circulating microRNA-200 family as a non-invasive tool to identify patients with cirrhosis-associated hepatocellular carcinoma (HCC.Prognosis of HCC remains poor with increasing incidence worldwide, mainly related to liver cirrhosis. So far, no reliable molecular targets exist for early detection of HCC at surgically manageable stages. Recently, we identified members of the microRNA-200 family as potential diagnostic markers of cirrhosis-associated HCC in patient tissue samples. Their value as circulating biomarkers for HCC remained undefined.Blood samples and clinicopathological data of consecutive patients with liver diseases were collected prospectively. Expression of the microRNA-200 family was investigated by qRT-PCR in blood serum samples of 22 HCC patients with and without cirrhosis. Serum samples of patients with non-cancerous chronic liver cirrhosis (n = 22 and of healthy volunteers (n = 15 served as controls.MicroRNA-141 and microRNA-200a were significantly downregulated in blood serum of patients with HCC compared to liver cirrhosis (p<0.007 and healthy controls (p<0.002. MicroRNA-141 and microRNA-200a could well discriminate patients with cirrhosis-associated HCC from healthy volunteers with area under the receiver-operating characteristic curve (AUC values of 0.85 and 0.82, respectively. Additionally, both microRNAs could differentiate between HCC and non-cancerous liver cirrhosis with a fair accuracy.Circulating microRNA-200 family members are significantly deregulated in patients with HCC and liver cirrhosis. Further studies are necessary to confirm the diagnostic value of the microRNA-200 family as accurate serum marker for cirrhosis-associated HCC.

  5. The Relationship Between Propulsive Force in Tethered Swimming and 200-m Front Crawl Performance.

    Science.gov (United States)

    Santos, Karini B; Bento, Paulo C B; Pereira, Gleber; Rodacki, André L F

    2016-09-01

    Santos, KB, Bento, PCB, Pereira, G, and Rodacki, ALF. The relationship between propulsive force in tethered swimming and 200-m front crawl performance. J Strength Cond Res 30(9): 2500-2507, 2016-The aims of this study were to determine whether propulsive force (peak force, mean force, impulse, and rate of force development) and stroke rate change during 2 minutes of front crawl tethered swimming and to correlate them with the stroke rate and swimming velocity in 200-m front crawl swimming. Twenty-one swimmers (21.6 ± 4.8 years, 1.78 ± 0.06 m, 71.7 ± 8.1 kg), with 200-m front crawl swimming performance equivalent to 78% of the world record (140.4 ± 10.1 seconds), were assessed during 2 minutes of maximal front crawl tethered swimming (propulsive forces and stroke rate) and 200-m front crawl swimming (stroke rate and clean velocity). Propulsive forces decreased between the beginning and the middle instants (∼20%; p ≤ 0.05) but remained stable between the middle and the end instants (∼6%; p > 0.05). The peak force was positively correlated with the clean velocity in the 200-m front crawl swimming (mean r = 0.61; p < 0.02). The stroke rates of the tethered swimming and 200-m front crawl swimming were positively correlated (r = 45; p≤ 0.01) at the middle instant. Therefore, the propulsive force and stroke rate changed throughout the 2 minutes of tethered swimming, and the peak force is the best propulsive force variable tested that correlated with 200-m front crawl swimming performance.

  6. Phase 1 remedial investigation report for 200-BP-1 operable unit. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    The US Department of Energy (DOE) Hanford Site, in Washington State is organized into numerically designated operational areas including the 100, 200, 300, 400, 600, and 1100 Areas. The US Environmental Protection Agency (EPA), in November 1989 included the 200 Areas of the Hanford Site on the National Priority List (NPL) under the Comprehensive Environmental Response, Compensation and Liability Act of 1980 (CERCLA). Inclusion on the NPL initiated the remedial investigation (RD process for the 200-BP-1 operable unit. These efforts are being addressed through the Hanford Federal Facility Agreement and Consent Order (Ecology et al. 1989) which was negotiated and approved by the DOE, the EPA, and the State of Washington Department of Ecology (Ecology) in May 1989. This agreement, known as the Tri-Party Agreement, governs all CERCLA efforts at Hanford. In March of 1990, the Department of Energy, Richland Operations (DOE-RL) issued a Remedial Investigation/Feasibility Study (RI/FS) work plan (DOE-RL 1990a) for the 200-BP-1 operable unit. The work plan initiated the first phase of site characterization activities associated with the 200-BP-1 operable unit. The purpose of the 200-BP-1 operable unit RI is to gather and develop the necessary information to adequately understand the risks to human health and the environment posed by the site and to support the development and analysis of remedial alternatives during the FS. The RI analysis will, in turn, be used by Tri-Party Agreement signatories to make a risk-management-based selection of remedies for the releases of hazardous substances that have occurred from the 200-BP-1 operable unit.

  7. 药物性肝损伤200例临床分析%Retrospective analysis of 200 patients with drug induced liver injury

    Institute of Scientific and Technical Information of China (English)

    张长平; 崔向丽; 王咏梅

    2014-01-01

    目的:探讨药物性肝损伤患者的临床特点及发病因素。方法回顾性分析药物性肝损伤患者服药史、临床表现、基础疾病、治疗及转归等。结果200例患者中女139例,男61例,涉及药品169种,其中前3位是中药(48.5%)、抗感染药(11.2%)、抗肿瘤药(8.2%)。患者基础疾病主要为心血管病(14.5%)、感染性疾病(10.3%)、皮肤病(8.8%)、骨关节病(8.4%)、肿瘤(7.9%)等。200例患者治愈146例,好转53例,死亡1例。结论引起肝损伤的药物以中药为主,临床表现形式多样,但转归较好。%Objective To investigate the characteristics and risk etiological factors of drug-induced liver injury(DILI) cases,and provide information for clinical prevention and treatment.Methods The clinical data of 200 patients (including 139 female and 71 male ) with DILI was retrospectively analyzed according to their history of medicine, clinical manifestations,underlying diseases,treatment and prognosis.Results These 200 cases involved 169 etiological drugs,of which the top 3 were traditional Chinese medicine,anti-infective drugs and anti-tumor drugs.The primary underlying diseases of these patients were cardiovascular disease,infectious diseases,skin diseases,osteoarthrosis,tumors and so on. Of those 200 patients,146 were cured,53 improved and 1 died.Conclusion DILI is dominated by traditional Chinese medicine,with various clinical manifestations and favorable prognosis.

  8. Expression and clinical significance of miR-181a, miR-200a, miR-200c in lung cancer tissues and cells%肺癌细胞及组织中miR-181a、miR-200a、miR-200c表达变化及意义

    Institute of Scientific and Technical Information of China (English)

    王勇; 李宇男; 于晓松

    2014-01-01

    Objective To observe the expression and significance of miR-181a, miR-200a, miR-200c in lung cancer tissues and cells.Methods RT-PCR method was used to detect the expression of miR-181a, miR-200a, miR-200c in lung cancer cell lines NCI-H1299, NCI-H358, H460, A549 and normal human bronchial epithelial cell line HBE , and in the lung cancer tissues and adjacent tissues .To analyze the relationship between the expression of miR-181a, miR-200a, miR-200c and clinicopathological parameters of lung cancer by means of Mann-Whitney.Results miR-181a expression in NCI-H1299, NCI-H358 and A549 were lower than that in HBE (all P0.05).miR-200c expression in lung cancer tissues was higher than that in cancer-adjacent tissues (P<0.01).miR-200a expression in the lung cancer patients with lymphatic metastasis was lower than that in lung cancer patients without lymphatic metastasis (P<0.01).Conclusions The expression of miR-181a, miR-200a were generally decreased , while miR-200c was generally increased in lung cancer cell lines and tissues , which maight be related to the occur of lung cancer .%目的:观察肺癌细胞及组织中 miR-181a、miR-200a、miR-200c 的表达变化,并探讨其临床意义。方法选择人肺癌细胞系NCI-H1299、NCI-H358、H460、A549及人正常支气管上皮细胞HBE,10例肺癌患者的癌组织及其相应癌旁组织。采用RT-PCR法检测各细胞系及组织中的miR-181a、miR-200a、miR-200c,并分析miRNA表达与临床参数的关系。结果 NCI-H1299、NCI-H358、A549细胞中miR-181a相对表达量均低于HBE细胞,NCI-H1299、NCI-H358、H460、A549细胞中miR-200a相对表达量均低于HBE细胞,NCI-H358、H460细胞中miR-200c相对表达量均高于HBE细胞,P均<0.05。肺癌及癌旁组织中miR-181a和miR-200a相对表达量比较,P均>0.05;肺癌组织中miR-200c相对表达量高于癌旁组织,P<0.01。有淋巴结转移的肺癌患者miR-200a相对表达量低

  9. FEASIBILITY STUDY REPORT FOR THE 200-ZP-1 GROUNDWATER OPERABLE UNIT

    Energy Technology Data Exchange (ETDEWEB)

    BYRNES ME

    2008-07-18

    The Hanford Site, managed by the U.S. Department of Energy (DOE), encompasses approximately 1,517 km{sup 2} (586 mi{sup 2}) in the Columbia Basin of south-central Washington State. In 1989, the U.S. Environmental Protection Agency (EPA) placed the 100, 200, 300, and 1100 Areas of the Hanford Site on the 40 Code of Federal Regulations (CFR) 300, 'National Oil and Hazardous Substances Pollution Contingency Plan' National Contingency Plan [NCPD], Appendix B, 'National Priorities List' (NPL), pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The 200 Areas NPL sites consist of the 200 West and 200 East Areas (Figure 1-1). The 200 Areas contain waste management facilities, inactive irradiated fuel reprocessing facilities, and the 200 North Area (formerly used for interim storage and staging of irradiated fuel). Several waste sites in the 600 Area, located near the 200 Areas, also are included in the 200 Areas NPL site. The 200 Areas NPL site is in a region referred to as the 'Central Plateau' and consists of approximately 700 waste sites, excluding sites assigned to the tank farm waste management areas (WMAs). The 200-ZP-1 Groundwater Operable Unit (OU) consists of the groundwater located under the northern portion of the 200 West Area. Waste sources that contributed to the 200-ZP-1 OU included cribs and trenches that received liquid and/or solid waste in the past from the Z Plant and T Plant aggregate areas, WMA-T, WMA-TX/TY, and the State-Approved Land Disposal Site (SALDS). This feasibility study (FS) for the 200-ZP-1 Groundwater OU was prepared in accordance with the requirements of CERCLA decision documents. These decision documents are part of the Administrative Record for the selection of remedial actions for each waste site and present the selected remedial actions that are chosen in accordance with CERCLA, as amended by the Superfund Amendments and Reauthorization Act of 1986

  10. MicroRNA-200 Family Profile: A Promising Ancillary Tool for Accurate Cancer Diagnosis.

    Science.gov (United States)

    Liu, Xiaodong; Zhang, Jianhua; Xie, Botao; Li, Hao; Shen, Jihong; Chen, Jianheng

    2016-01-01

    Cancer is one of the most threatening diseases in the world and great interests have been paid to discover accurate and noninvasive methods for cancer diagnosis. The value of microRNA-200 (miRNA-200, miR-200) family has been revealed in many studies. However, the results from various studies were inconsistent, and thus a meta-analysis was designed and performed to assess the overall value of miRNA200 in cancer diagnosis. Relevant studies were searched electronically from the following databases: PubMed, Embase, Web of Science, the Cochrane Library, and Chinese National Knowledge Infrastructure. Keyword combined with "miR-200," "cancer," and "diagnosis" in any fields was used for searching relevant studies. Then, the pooled sensitivity, specificity, area under the curve (AUC), and partial AUC were calculated using the random-effects model. Heterogeneity among individual studies was also explored by subgroup analyses. A total of 28 studies from 18 articles with an overall sample size of 3676 subjects (2097 patients and 1579 controls) were included in this meta-analysis. The overall sensitivity and specificity with 95% confidence intervals (95% CIs) are 0.709 (95% CI: 0.657-0.755) and 0.667 (95% CI: 0.617-0.713), respectively. Additionally, AUC and partial AUC for the pooled data is 0.735 and 0.627, respectively. Subgroup analyses revealed that using miRNA-200 family for cancer diagnosis is more effective in white than in Asian ethnic groups. In addition, cancer diagnosis by miRNA using circulating specimen is more effective than that using noncirculating specimen. Finally, miRNA is more accurate in diagnosing endometrial cancer than other types of cancer, and some miRNA family members (miR-200b and miR-429) have superior diagnostic accuracy than other miR-200 family members. In conclusion, the profiling of miRNA-200 family is likely to be a valuable tool in cancer detection and diagnosis.

  11. Continuous pulse oximetry in the general surgical ward: Nellcor N-200 versus Nellcor N-3000

    DEFF Research Database (Denmark)

    Christensen, M; Lie, C; Rosenberg, J

    1999-01-01

    Symphony N-3000 with the Nellcor N-200 pulse oximeter, when monitoring patients in the general surgical ward. Twenty-two patients were monitored during unrestricted ward activities for a total of 275 h with a N-3000 and a N-200 pulse oximeter simultaneously. Data were analysed for lack of concordance...... between the two pulse oximeters with respect to frequency of registered hypoxaemic episodes and thus the amount of time spent in the alarm state. The median number of desaturation episodes with the N-200 was 18 (range 0-511) compared with four (range 0-476) with the N-3000 (p ... of drop-outs (loss of signal) was 13 (range 1-46) with the N-200 compared with nine (2-41) with the N-3000 (p = 0.06). The N-200 registered saturation values of 85% or below for 23% of the observation time compared with 6% of the observation time with the N-3000 pulse oximeter (p

  12. R&S DST200让OTA自动测量简单易行

    Institute of Scientific and Technical Information of China (English)

    丁丁

    2012-01-01

    R&S DST200射频诊断暗室可配置自动的三维定位器,这大大方便了研发和质保阶段进行OTA和RSE的自动测量。这个测试暗室是市场上最紧凑的产品,它使用户可以直接在实验室工作台上进行测量,用户将会非常欣喜地发现,用R&S DST200获得的结果与采用大型OTA测试试验室获得的结果间有很好的相关性。罗德与施瓦茨中国有限公司丁丁所撰《R&S DST200让OTA自动测量简单易行》一文对R&S DST200系统进行了详细的介绍,并就R&S DST200对OTA进行的测量进行了研究和分析。

  13. 13 CFR 126.200 - What requirements must a concern meet to receive SBA certification as a qualified HUBZone SBC?

    Science.gov (United States)

    2010-01-01

    ... meet to receive SBA certification as a qualified HUBZone SBC? 126.200 Section 126.200 Business Credit... SBC § 126.200 What requirements must a concern meet to receive SBA certification as a qualified HUBZone SBC? (a) Concerns owned by Indian Tribal Governments—(1) Ownership. (i) The concern must be...

  14. JAERI 200 kV Electron Gun with an NEA-GaAs Photocathode

    CERN Document Server

    Nishitani, Tomohiro; Kikuzawa, Nobuhiro; John Minehara, Eisuke; Nagai, Ryoji; Nishimori, Nobuyuki; Sawamura, Masaru; Yamauchi, T

    2004-01-01

    The GaAs photocathode with negative electron affinity surface (NEA-GaAs) has been expected to be low emittance (<0.5 πmm・mrad) electron beam source. In order to generate low emittance electron beam required from ERL-FEL, we have started the developmental program of a 200keV electron gun with the NEA-GaAs photocathode for the first time in JAERI. An NEA surface has the problem that lifetime is limited by gun vacuum condition and by ion back bombardment between anode- and cathode-electrode. In order to long an NEA surface lifetime, the JAERI 200keV electron gun system consists of a 200kV DC-gun chamber on extreme high vacuum condition and an NEA activation chamber with load-lock system.

  15. Development of a 1 kW, 200 C Mapham Inventor

    Science.gov (United States)

    Hammoud, Ahmad; Gerber, Scott; Bauman, Eric; Overton, Eric; Myers, Ira; Bercaw, Robert

    1995-01-01

    Electronic systems and components are often exposed to high temperature environment in space-based applications, nuclear power facilities, and geothermal energy extraction fields. A key requirement for these systems is, therefore, to withstand the high temperature exposure while maintaining efficient and reliable operation. Efforts were taken to design and develop a high temperature power inverter capable of 200 C operation. A 1 kW, 20 kHz Mapham inverter was designed and evaluated as a function of temperature at different load levels. The inverter system, excluding its input, control, and logic circuits, was characterized at temperatures from ambient to 200 C at 0%, 50%, and 100% resistive loading. With an applied input voltage of 75 VDC, the inverter produced an output of 250 VAC. The results obtained, which indicate good operational characteristics of the inverter up to 200 C, are presented and discussed.

  16. Development of the CCP-200 mathematical model for Syzran CHPP using the Thermolib software package

    Science.gov (United States)

    Usov, S. V.; Kudinov, A. A.

    2016-04-01

    Simplified cycle diagram of the CCP-200 power generating unit of Syzran CHPP containing two gas turbines PG6111FA with generators, two steam recovery boilers KUP-110/15-8.0/0.7-540/200, and one steam turbine Siemens SST-600 (one-cylinder with two variable heat extraction units of 60/75 MW in heatextraction and condensing modes, accordingly) with S-GEN5-100 generators was presented. Results of experimental guarantee tests of the CCP-200 steam-gas unit are given. Brief description of the Thermolib application for the MatLab Simulink software package is given. Basic equations used in Thermolib for modeling thermo-technical processes are given. Mathematical models of gas-turbine plant, heat-recovery steam generator, steam turbine and integrated plant for power generating unit CCP-200 of Syzran CHPP were developed with the help of MatLab Simulink and Thermolib. The simulation technique at different ambient temperature values was used in order to get characteristics of the developed mathematical model. Graphic comparison of some characteristics of the CCP-200 simulation model (gas temperature behind gas turbine, gas turbine and combined cycle plant capacity, high and low pressure steam consumption and feed water consumption for high and low pressure economizers) with actual characteristics of the steam-gas unit received at experimental (field) guarantee tests at different ambient temperature are shown. It is shown that the chosen degrees of complexity, characteristics of the CCP-200 simulation model, developed by Thermolib, adequately correspond to the actual characteristics of the steam-gas unit received at experimental (field) guarantee tests; this allows considering the developed mathematical model as adequate and acceptable it for further work.

  17. Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer

    Directory of Open Access Journals (Sweden)

    Kan Casina WS

    2012-12-01

    Full Text Available Abstract Background There is a critical need for improved diagnostic markers for high grade serous epithelial ovarian cancer (SEOC. MicroRNAs are stable in the circulation and may have utility as biomarkers of malignancy. We investigated whether levels of serum microRNA could discriminate women with high-grade SEOC from age matched healthy volunteers. Methods To identify microRNA of interest, microRNA expression profiling was performed on 4 SEOC cell lines and normal human ovarian surface epithelial cells. Total RNA was extracted from 500 μL aliquots of serum collected from patients with SEOC (n = 28 and age-matched healthy donors (n = 28. Serum microRNA levels were assessed by quantitative RT-PCR following preamplification. Results microRNA (miR-182, miR-200a, miR-200b and miR-200c were highly overexpressed in the SEOC cell lines relative to normal human ovarian surface epithelial cells and were assessed in RNA extracted from serum as candidate biomarkers. miR-103, miR-92a and miR -638 had relatively invariant expression across all ovarian cell lines, and with small-nucleolar C/D box 48 (RNU48 were assessed in RNA extracted from serum as candidate endogenous normalizers. No correlation between serum levels and age were observed (age range 30-79 years for any of these microRNA or RNU48. Individually, miR-200a, miR-200b and miR-200c normalized to serum volume and miR-103 were significantly higher in serum of the SEOC cohort (P  Conclusions We identified serum microRNAs able to discriminate patients with high grade SEOC from age-matched healthy controls. The addition of these microRNAs to current testing regimes may improve diagnosis for women with SEOC.

  18. Level of Copper Ion in Cervical Mucus of Various Duration after Inserting VCu200 IUD

    Institute of Scientific and Technical Information of China (English)

    刘庆喜; 黄祝姈; 潘琢如

    1996-01-01

    The purpose of the study was to test the effective period of VCu200 IUD. The concentration of copper ion was measured with non-flame atomic absorption s pectrophotometer HITACHI- 180. The average concentration of copper ion(x±sx) was 2.66±0.58 μg/g cervical mucus wet weight (μg/g · M·W·W) in the first year, then gradually decreasing to 0.91±0. 16 μg/g·M·W·W in the fifteenth-year group of VCu200 IUD. There was an average of 0.35±0.08~0. 56±0. 14 μg/g·M·W·W in the control group. It showed that the concentration of copper ion was decreasing with prolongation of use of VCu200 IUD and there was statistically significant difference between VCu200 IUD group, on the one hand, and the stainless steel ring group and the control group (P<0.05~0. 01) on the other hand. No difference was found between the stainless steel ring group and the control group (P>0. 05). It was reported in the literature that the concentration of copper ion in 1.0 μg/ml had the action of anti fertility, and it was found that the concentration of copper ion was higher than 1.0 μg/ml in the tenth year after insertion of VCu200 IUD. It suggested that effective period of VCu200 IUD was at least ten years.

  19. A 10 bits 200Msps Current-Steering DAC%10比特200Msps电流舵DAC的设计

    Institute of Scientific and Technical Information of China (English)

    金锐; 万培元; 郭乐乐; 林平分

    2012-01-01

    实现了一款10比特200Msps采样速度的数模转换器。该数模转换器采用了8+2的分段结构,高8位比特使用温度码设计。文中详细分析了CMOS工艺下匹配问题,采取一定措施提高匹配性。该数模转换器采用3.3V供电电压,摆幅为2Vpp,提高了系统的抗干扰能力。在200Msps采样率下,后仿真结果可达到INL小于0.34LSB,DNL小于0.05LSB,有效比特数为9.9,SNDR达到61.7dB,SFDR为75.3dB。该DAC采用SMIC180nmCMOS工艺设计,整体面积为800*800μm。。%A 10 bits 200Msps current steering digital to analog converter was described in this work. The DAC consists of a unit current cell for 8MSBs, and a binary weighted array for 2LSBs. In this paper, mismatch problem is analysis in detail. This ADC was supplied at 3.3V, swing was 2Vpp, and the high swing improved the SNR. The integral nonlinearity error is less than 0.34LSB, and the differential nonlinearity error is less than 0.02LSB. The ENOB is 9.9, the SNDR is 61.7, the SFDR is 75.3dB. This work is designed under smicl80nm CMOS process. The total area is 800*800 μ m2

  20. 200 GPa压力范围内铝和铜的等熵压缩线计算%Compression Isentropes of Aluminum and Copper up to 200 GPa

    Institute of Scientific and Technical Information of China (English)

    莫建军; 孙承纬

    2006-01-01

    将冲击Hugoniot线作为Grüneisen物态方程的参考线,以冲击的初始状态为参考状态,推导得到线性和二次曲线表示的冲击绝热线所对应的等熵压缩线方程,计算了200 GPa压力范围内铝和铜两种材料的等熵压缩线,并且计算了以Hugoniot关系为基础的Appy经验物态方程导出的等熵压缩线.计算结果表明,以Appy经验物态方程导出的等熵压缩线与以线性冲击绝热线导出的等熵压缩线接近,在200 GPa压力范围内两者相差不到1.5%.将计算得到的铝的等熵压缩线与美国Sandia实验室ICE实验Z864数据进行了比较,由线性Hugoniot得到的等熵压缩线与实验数据相差不到1%,由Appy经验物态方程得到的等熵线与实验数据几乎重合,说明在200 GPa压力范围内,以Appy物态方程和以线性Hugoniot为参考来计算的等熵压缩线有较高的精度.

  1. Study of prevalence of headache and its various facets among 200 medical students

    OpenAIRE

    Patel, Maharshi Vinod; Patel, Hiren Bhuljibhai; Thakkar, Shivam; Shah, Vidhi; Suratia, Bhumi; Thummar, Shaili; Vachhani, Ruchi; Vadodaria, Bansari

    2016-01-01

    Aim: The aim of study is to study the prevalence of headache and its various facets among 200 medical students of SBKSMI & RC.Objectives:1) To find out the common causes of headache among medical students. 2) To find out gender difference in prevalence of headaches among medical student. 3) To determine the severity and frequency of headache. 4) To find out various relieving factors used by medical students for headacheMaterials and Methods: Cross-sectional study was done among 200 medica...

  2. Always on the starting line: ELCAT 200 - the new-generation electric vehicle

    Energy Technology Data Exchange (ETDEWEB)

    Baeckstroem, K.; Leisio, C. [ed.

    1997-11-01

    The Elcat 200 electric van can always be left charging. With most other electric van models, the situation is different. They run the risk of overcharging, which prevents continual `refuelling` of their batteries and thus considerably reduces the performance of the vehicles. The Elcat electric vehicle project has so far manufactured over 160 electric vans. Of these, the Elcat Cityvan accounts for 130, and the state-of-the-art Elcat 200 just over 30. The greatest single Elcat user is Finland Post, with 50 electric vehicles. Fifty Elcats have been sold abroad, most of them to Sweden

  3. Results from Cu+Au collisions at 200 GeV in PHENIX Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Berdnikov, Ya. A.; Kotov, D. O.; Safonov, A. S. [Federal State Autonomous Educational Institution of Higher Education “Saint-Petersburg State Polytechnical University” (Russian Federation); Ivanishchev, D. A.; Riabov, V. G.; Riabov, Yu. G.; Samsonov, V. M. [Petersburg Nuclear Physics Institute B.P. Konstantinov, National Research Centre “Kurchatov Institute” (Russian Federation)

    2016-01-22

    Collisions of asymmetric nuclei (Cu+Au) differ essentially from the case of symmetric nuclei (Cu+Cu, Au+Au) collisions in the geometry of overlap region. This leads to a number of consequences, which provide more absolute and accurate information about fundamental properties of matter under extreme conditions. Nuclear modification factors for π-mesons in Cu+Au interactions at 200 GeV were measured in PHENIX Experiment at RHIC. New experimental data on measurement of flows of different order (v{sub 1}, v{sub 2}) for light hadrons in Cu+Au interactions at 200 GeV will be discussed in this paper.

  4. Genomic structure in Europeans dating back at least 36,200 years

    DEFF Research Database (Denmark)

    Seguin-Orlando, Andaine; Korneliussen, Thorfinn Sand; Sikora, Martin;

    2014-01-01

    The origin of contemporary Europeans remains contentious. We obtained a genome sequence from Kostenki 14 in European Russia dating from 38,700 to 36,200 years ago, one of the oldest fossils of anatomically modern humans from Europe. We find that Kostenki 14 shares a close ancestry with the 24,000...... European Neolithic farmers. We find that Kostenki 14 contains more Neandertal DNA that is contained in longer tracts than present Europeans. Our findings reveal the timing of divergence of western Eurasians and East Asians to be more than 36,200 years ago and that European genomic structure today dates...

  5. Effectiveness of the GT200 Molecular Detector: A Double-Blind Test

    CERN Document Server

    Mochán, W Luis

    2013-01-01

    The GT200 is a device that has been extensively used by the Mexican armed forces to remotely detect and identify substances such as drugs and explosives. A double blind experiment has been performed to test its effectivity. In seventeen out of twenty attempts, the GT200 failed in the hands of certified operators to find more than 1600 amphetamine pills and four bullets hidden in a randomly chosen cardboard box out of eight identical boxes distributed within a 90m$\\times$20m ballroom. This result is compatible with the 1/8 probability expected for a completely ineffectual device, and is incompatible with even a moderately effective working one.

  6. The immunoglobulin superfamily member CD200R identifies cells involved in type 2 immune responses

    DEFF Research Database (Denmark)

    Blom, Lars H; Martel, Britta C; Larsen, Lau F

    2017-01-01

    BACKGROUND: The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim...... and ILC2 cells and basophils. In peanut-allergic subjects the peanut-specific Th2 (CD154(+) CRTh2(+) ) cells expressed more CD200R than the non-allergen specific Th2 (CD154(-) CRTh2(+) ) cells. Moreover, co-staining of CD161 and CD200R identified peanut-specific highly differentiated IL-4(+) IL-5(+) Th2...

  7. mproved enema method glycerine enema 200ml%改良的开塞露200 ml的灌肠方法

    Institute of Scientific and Technical Information of China (English)

    张洪越; 叶兰凤

    2014-01-01

    cosmeticsurgeryafterthecustomerduetotheimpactofpain,diet,activity,livingenvironment,andotheraspectsofthepostoperativeabdominaldistension,oftenexistsand is not easy to bowel symptoms,including we commonly used solution:enema 20-40ml anus,oral phenolphthalein tablet,Maren Pil s,told customers eat crude fiber foods for example,celery, sweet potato,taro;fruit:kiwi fruit,dragon fruit,apple,banana etc..The 200ml glycerine enema,the conventional method is to use the 50ml injection of glycerine enema syringe nipple aspira-tion after connected with a sputum suction tube inserted into the anus after lubrication,divided into four times operation steps,sputum suction tube is hard,insert the anus,customers wil not comfortable,my branch uses the method of enema with Kaiselu 200ml improved,after the clinical use,the ef ect is bet er,introduce as fol ows now.%I美容整形手术后顾客因术后疼痛、饮食、活动、居住环境、麻药等方面的影响,往往存在腹胀、不易排便的症状,我院现常用的解决方法包括:开塞露20-40ml纳肛、口服酚酞片、麻仁丸、嘱顾客多食粗纤维食物例如:芹菜、红薯、芋头等;水果有:猕猴桃、火龙果、苹果、香蕉等。200ml开塞露灌肠,以往常规方法是用50ml注射器抽吸开塞露后,注射器乳头接吸痰管,润滑后插入肛门,分四次进行操作,步骤多,吸痰管较硬,插入肛门,顾客会有不舒适感,我科采用了改良的开塞露200ml的灌肠方法,经过临床使用,效果较好,现介绍如下:

  8. New Technique for Re200c Catenary Construction on Hada Line%哈大线Re200C接触网工程施工新技术

    Institute of Scientific and Technical Information of China (English)

    朱飞雄

    2003-01-01

    通过借鉴和消化吸收国外的先进技术和施工管理经验,中铁电气化局在哈大线Re200C接触网施工中采用了许多新颖的技术和管理方法,本文介绍这些管理模式、施工特点、质量检测方法和施工允许偏差等.

  9. HY200远动系统RTU技术实现%The Techniques to Implement RTU of HY200 Remote Control System

    Institute of Scientific and Technical Information of China (English)

    林知明; 陈剑云; 钟化兰

    2000-01-01

    介绍了HY200型远动系统RTU软硬件实现的技术方法.讨论了主要硬部件的性能和作用,并给出了硬件系统结构图,提供了软件模块化设计的关系结构图,并对各主要模块的作用及软件设计原理作了详细的说明.

  10. Clinical pathological analysis of 200 cases of salivary gland tumors%涎腺肿瘤200例临床病理分析

    Institute of Scientific and Technical Information of China (English)

    符攀峰

    2016-01-01

    Objective:To investigate the clinicopathological features of salivary gland tumors,and to improve the diagnostic accuracy.Methods:200 patients with salivary gland tumors were selected.We analyzed the place of occurrence,clinical symptoms and pathological diagnosis results.Results:The tumor occurring in the submandibular gland accounted for 26.0%,occurred in the sublingual gland accounted for 5.0%,occurred in oral accounted for 1.0%,occurred in the throat accounted for 0.5% in 200 cases of patients.The clinical symptoms of the patients in this group is mainly painless mass occurred in the part of salivary gland tumors,and the majority of patients with this tumor growth slow.In this group,132 cases were benign tumors,and the rest were malignant tumors.Conclusion:Salivary gland tumors likely occur in the parotid,submandibular and sublingual glands and other parts,more benign lesions,but we should judge the differentiation of benign and malignant tumors,which is conducive to the correct diagnosis and selection of treatment measures.%目的:探讨涎腺肿瘤的临床病理特点,提高其诊断正确率。方法:收治涎腺肿瘤患者200例。分析其发病部位、临床症状、病理诊断结果。结果:200例患者中肿瘤发生在腮腺67.5%、颌下腺26.0%、舌下腺5.0%、口腔1.0%、喉部0.5%。本组患者临床症状主要为涎腺肿瘤所在部位出现无痛性肿块、多数患者此肿块生长缓慢。本组患者中良性肿瘤132例,其余为恶性肿瘤。结论:涎腺肿瘤好发于腮腺、颌下腺及舌下腺等部位,良性病变较多,但要做好良恶性鉴别,利于正确诊断及选择治疗措施。

  11. Design features of 4×200 MW level IGCC project%4×200MW级IGCC项目设计特点

    Institute of Scientific and Technical Information of China (English)

    王泓; 谭红军

    2008-01-01

    整体煤气化联合循环发电(IGCC)技术是一种很有发展前景的洁净煤发电技术.论述了IGCC技术的工艺流程,针对某电厂4 × 200 MW级IGCC项目,详细介绍了该项目的工艺系统和设备选型方案,指出建设以自主技术为主的IGCC电站必将推动我国IGCC发电技术的发展.

  12. Hybrid Powered Vehicle kihaE200 of JR EAST%JR东日本公司kihaE200型混合动力车辆

    Institute of Scientific and Technical Information of China (English)

    大村哲朗; 石清伶

    2008-01-01

    JR东日本公司为了降低在非电气化区间运行的内燃动车对环境的污染,开发了内燃混合动力车辆,该车辆具有内燃发动机和蓄电池组合的动力系统,验证了该车辆在运营中的环境污染、蓄电池性能和维护性能.新造了批量生产用的样板车kihaE200型混合动力车辆.

  13. Structural Basis for Substrate and Oxygen Activation in Homoprotocatechuate 2,3-Dioxygenase: Roles of Conserved Active Site Histidine-200

    OpenAIRE

    Kovaleva, Elena G.; Rogers, Melanie S.; Lipscomb, John D.

    2015-01-01

    Kinetic and spectroscopic studies have shown that the conserved active site residue His200 of the extradiol ring-cleaving homoprotocatechuate 2,3-dioxygenase (FeHPCD) from Brevibacterium fuscum is critical for efficient catalysis. The roles played by this residue are probed here by analysis of the steady state kinetics, pH dependence, and X-ray crystal structures of the FeHPCD position 200 variants His200Asn, His200Gln, and His200Glu alone and in complex with three catecholic substrates (homo...

  14. Behavior of rats treated with Rhus toxicodendron 200cH Conducta da ratones tratados con Rhus toxicodendron 200cH Conduta de ratos tratados com Rhus toxicodendron 200cH

    Directory of Open Access Journals (Sweden)

    Leoni Villano Bonamin

    2008-03-01

    Full Text Available One of the main pathogenetic characteristics of Rhus toxicodendron (Rhus-t is the presence of articular pain and aggravation on standing, which improve only by motion. The present study proposes an experimental model to evaluate the action of Rhus-t 200cH. Rats were divided into 3 groups according to treatment received (Rhus-t, diazepam and water; each group was further divided into two sub-groups according to the initial pattern of behavior (hyperactive and hypoactive as assessed by open-field procedure. A second evaluation of behavior performed 24 hours later pointed out to the effects of the medications under study. Results were analyzed through Kruskal-Wallis/Dunn’s test, with a level of significance p=0.05. Keywords: Rhus toxicodendron; Animal behavior; Open-field; Idiosyncrasy.   Conduta de ratos tratados com Rhus toxicodendron 200cH Resumo Uma das características patogenéticas principais de Rhus toxicodendron (Rhus-t é a presença de dor articular e agravação em pé, melhorando exclusivamente com o movimento. O presente estudo propõe um modelo experimental para avaliar a ação de Rhus-t 200cH. Ratos foram divididos em 3 grupos de tratamento (Rhus-t, diazepam e água; cada grupo doi subdividido em 2 subgrupos de acordo com o padrão inicial de conduta (hiper e hipoativos em procedimento de campo aberto. Uma segunda avaliação da conduta, realizada 24 horas após, indicou o efeito dos medicamentos sob estudo. Os resultados foram analisados pelo teste de Kruskal-Ealis/Dunn com nível de significância p=0,05. Palavras-chave: Rhus toxicodendron; comportamento animal; Campo aberto; idiossincrasia.   Conducta da ratones tratados con Rhus toxicodendron 200cH Resumen Una de las principales características patogenéticas de Rhus toxicodendron (Rhus-t es la presencia de dolor articular y

  15. 13-bit 200MSPS Pipeline ADC Analog Circuits Design with LMS Digital Calibration%采用LMS数字校准的13位200MSPS ADC设计

    Institute of Scientific and Technical Information of China (English)

    高俊枫; 谌博; 李广军; 李强

    2011-01-01

    本文设计了无采保电路流水线ADC,并且采用LMS校准技术对ADC前三级3阶和5阶非线性误差进行数字校准。精心设计的运放和开关使MDAC的闭环非线性仅为7LSB左右。仿真结果表示200MSPS采样率的流水线ADC在输入达到83.13M时可以达到77dB的SNDR。%A SHA less pipeline ADC is designed by the paper, with the 3rd-order and 5th-order nonlinearity of thefirst three stages calibrated by LMS calibration technique. Around 7LSB closed-loop nonlinearity of MDAC is achieved by carefully consider the opamps and switches. Simulation shows the SNDR of the proposed ADC at200MSPS sampling rate is 77dB with 83.13MHz input.

  16. CITIBANK: BOARD-ORIENTED MANAGEMENT OVER THE PAST 200 YEARS%花旗银行:200年董事会核心路

    Institute of Scientific and Technical Information of China (English)

    仲继银

    2011-01-01

    @@ 花旗银行在从一个纽约城市银行成长为全球性银行的近200年历史中,经历过无数次的危机、并购与重组,可谓纷繁复杂.但其一开始就在强有力的董事会领导之下,从"所有者管理型企业"到"经理人管理型企业"的治理结构演变过程却是清晰可辨.泰勒:一群商人的银行变为一个商人的银行 花旗银行的自前身是成立于1791年的美国第一银行纽约分行,1812年塞缪尔·奥斯古德将其重组力"纽约城巾银行--花旗银行早期的正式名称.1812年6月,花旗银行以200万美元授权资本和80万美元实收资本注册成立.

  17. 200例抗精神病药物使用临床观察%Clinical observation on antipsychotics used in 200 geriopsychosis patients

    Institute of Scientific and Technical Information of China (English)

    张代江

    2013-01-01

    Objective To study the clinical value of medication for the geriopsychosis patients. Methods The clinical data in 200 geriopsychosis patients hospitalized for over 2 weeks in this hospital were performed the retrospective analysis. Results Organic mental disorder had the lowest dose level,followed by alcohol induced mental disorder and mood disorders. Schizophrenia had the highest dose level. Mental disorder coexisting somatic diseases had the lower dose of antipsychotic drugs. Conclusion The princi pies of individualization, small dose and single medication should be applied in treating the geriopsychosis patients.%目的 探讨老年精神病患者药物使用的临床价值.方法 回顾性分析该院住院治疗2周以上的老年精神病患者200例的临床资料.结果 器质性精神障碍使用剂量最小,其次为酒精所致精神障碍、情感障碍,使用剂量最高为精神分裂症患者.共患躯体疾病者使用抗精神病药剂量较小.结论 对老年精神病患者遵循个体化、小剂量和单一用药进行治疗.

  18. The Movement Control of Manipulator Based on S7-200PLC%基于S7-200PLC的机械手运动控制

    Institute of Scientific and Technical Information of China (English)

    陈冬梅

    2014-01-01

    基于S7-200PLC对机械手的运动进行一系列控制,这些运动包括手臂上下、左右直线运动,手腕旋转运动,手爪夹紧动作和机械手整体旋转运动等。所采用的动力机构是步进电机,能够做到精确控制。在多个行程开关传感器的保护下,保证了这些运动万无一失。%The various movements of manipulator are controlled based on S7-200PLC. These movements include arms' up and down, left and right straight movements, wrist rotation, gripper clamping action and manipulator overall spin movement, etc. The power mechanism adopted is stepper motor, which can achieve precise control. Under the protection of multiple trip switch sensors, those movements are perfectly performed.

  19. Dreaming and Recall during Propofol Anaesthesia for Colonoscopy in 200 Patients%200例无痛肠镜患者梦境调查和分析

    Institute of Scientific and Technical Information of China (English)

    李春雨; 李荦芸; 赵海潮; 侯泽宇; 田宇; 宋璟; 贾晋太

    2015-01-01

    观察无痛肠镜患者实施丙泊酚麻醉后的做梦情况。采用问卷调查方法对200例实施无痛肠镜诊疗结束的患者做梦情况进行研究。200例患者分为做梦者(D 组)和无梦者(N 组)两组。结果200例无痛肠镜患者做梦发生率为32.50%,梦境回忆者有35人(占做梦者的53.85%),其中有3 人梦境回忆内容与性梦有关。麻醉状态指数(CSI)无痛肠镜操作开始、操作3min 时 D 组明显低于 N 组;年龄 D 组小于 N 组,丙泊酚用量 D 组明显高于 N 组。做梦者发生率与性别、ASA分级、教育程度、种族和睡眠质量相关。无痛肠镜诊疗丙泊酚麻醉梦境发生是一种常见现象,受多种因素影响。给患者提供一个良好愉悦的心理和生理舒适诊疗体验很有必要,使服务更具人性、人伦和人情,让患者在心理和精神层面获得巨大满足。%To investigate dreaming and recall during propofol anaesthesia for colonoscopy . It studied 200 patients by questionnaire interviewing .200 patients were divided into two groups of dream and no dream .General information , monitoring index ,propofol dosage and duration of anesthesia were observed and recorded .The incidence of dream was reported in 32 .5% of patients .Dream recall was reported in 53 .85% dreaming of patients .There were only three dreams even remotely related to sexual content .CSI had significant at begin of operation and 3min after operation (in the dream group) .Age and dosage of propofol had significant in the dream group .Gender ,ASA physical status ,education level , nation and sleep quality had significance on dream recall .Dream recall is a common phenomenon for colonoscopy patients with propofol anesthesia , and is related to various factors .It is necessary to provide patients with a good pleasant psychological and physiological comfort treatment experience and to make the service more human .It has great satisfaction in the

  20. Sequence and phylogenetic analysis of the gp200 protein of Ehrlichia canis from dogs in Taiwan.

    Science.gov (United States)

    Huang, Chia-Chia; Hsieh, Yu-Chen; Tsang, Chau-Loong; Chung, Yang-Tsung

    2010-12-01

    Ehrlichia (E.) canis is a Gram-negative obligate intracellular bacterium responsible for canine monocytic ehrlichiosis. Currently, the genetic diversity of E. canis strains worldwide is poorly defined. In the present study, sequence analysis of the nearly full-length 16S rDNA (1,620 bp) and the complete coding region (4,269 bp) of the gp200 gene, which encodes the largest major immunoreactive protein in E. canis, from 17 Taiwanese samples was conducted. The resultant 16S rDNA sequences were found to be identical to each other and have very high homology (99.4~100%) with previously reported E. canis sequences. Additionally, phylogenetic analysis of gp200 demonstrated that the E. canis Taiwanese genotype was genetically distinct from other reported isolates obtained from the United States, Brazil, and Israel, and that it formed a separate clade. Remarkable variations unique to the Taiwanese genotype were found throughout the deduced amino acid sequence of gp200, including 15 substitutions occurring in two of five known species-specific epitopes. The gp200 amino acid sequences of the Taiwanese genotype bore 94.4~94.6 identities with those of the isolates from the United States and Brazil, and 93.7% homology with that of the Israeli isolate. Taken together, these results suggest that the Taiwanese genotype represents a novel strain of E. canis that has not yet been characterized.

  1. 2012 North Plains research field 12-200 limited irrigation corn production study

    Science.gov (United States)

    2012 represented the third sequential year of research regarding the limited irrigation 12-200 corn production assessment study at the North Plains Research Field (NPRF) with the yield results being improved from that of the 2011 season but less than of the 2010 season. The study's purpose was to ev...

  2. Oral two-generation reproduction toxicity study with NM-200 synthetic amorphous silica in Wistar rats

    NARCIS (Netherlands)

    Wolterbeek, A.; Oosterwijk, T.; Schneider, S.; Landsiedel, R.; Groot, D. de; Ee, R. van; Wouters, M.; Sandt, H. van de

    2015-01-01

    Synthetic amorphous silica (SAS) like NM-200 is used in a wide variety of technological applications and consumer products. Although SAS has been widely investigated the available reproductive toxicity studies are old and do not cover all requirements of current OECD Guidelines. As part of a CEFIC-L

  3. 24 CFR 200.37 - Preventing crime in federally assisted housing.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Preventing crime in federally... Programs; and Continuing Eligibility Requirements for Existing Projects Miscellaneous Cross Cutting Regulations § 200.37 Preventing crime in federally assisted housing. See part 5, subparts I and J of...

  4. 46 CFR 170.200 - Estimated lightweight vertical center of gravity.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Estimated lightweight vertical center of gravity. 170... Centers of Gravity § 170.200 Estimated lightweight vertical center of gravity. (a) Each tank vessel that... calculations required by §§ 170.170 and 172.065, the vertical center of gravity of a tank vessel in...

  5. Climate Prediction Center (CPC) Area-average 200-hPa Zonal Wind Anomalies

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This is one of the CPC?s Monthly Atmospheric and SST Indices. It is the 200-hPa zonal wind anomalies averaged over the area 5oN ? 5oS, 165oW-110oW. The anomalies are...

  6. Radioactive liquid wastes discharged to ground in the 200 Areas during 1978

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, J. D.; Poremba, B. E.

    1979-03-26

    This document is issued quarterly for the purpose of summarizing the radioactive liquid wastes that have been discharged to the ground in the 200 Areas. In addition to data for 1978, cumulative data since plant startup are presented. Also, in this document is a listing of decayed activity to the various plant sites.

  7. 200 000 krooniga tudengeid ei peibuta / Anneli Aasmäe

    Index Scriptorium Estoniae

    Aasmäe, Anneli, 1973-

    2007-01-01

    Küsitlus Tallinna Ülikooli tudengite hulgas näitas, et kehtima hakkav lähtetoetus pole nende ametivalikut mõjutanud, pigem näevad nad 200 000 krooni suuruses summas mitmesuguseid ohtusid. Vt. samas: Lühiintervjuu haridus- ja teadusminister Tõnis Lukasega

  8. Measurements on the SPS 200 MHz Travelling Wave Cavity towards an Impedance Model

    CERN Document Server

    Roggen, Toon; Caspers, Fritz; Vollinger, Christine; CERN. Geneva. ATS Department

    2016-01-01

    This note discusses the contribution of the SPS 200 MHz TWC (Travelling Wave Cavity) to the SPS longitudinal impedance model. The measurement method and setup is briefly explained and a comparison with simulations is discussed for both the fundamental pass band (FPB) as well as the Higher Order Modes (HOMs). In addition a number of improvements to the measurement setup are discussed.

  9. Electrical Conductivity Of Diamond Up To 1,200 Degrees C

    Science.gov (United States)

    Vandersande, Jan W.; Zoltan, Leslie D.

    1993-01-01

    Report discusses measurements of electrical conductivities of two synthetic diamond films, three synthetic diamondlike films, and two natural type IIa diamonds at temperatures from ambient to 1,200 degrees C. Measurements performed to compare electrical conductivities of state-of-the-art diamond films with those of natural insulating diamond, particularly at temperatures above 700 degrees C.

  10. Šveitsi firma plaanib investeerida Repo Vabrikutesse 200 miljonit krooni / Gerli Romanovitsh

    Index Scriptorium Estoniae

    Romanovitš, Gerli, 1977-

    2005-01-01

    Ilmunud ka: Severnoje Poberezhje 1. sept. lk 1,3. AS-i Repo Vabrikud omanik, Šveitsi investeerimisfirma Sorbes AG, kellele kuulus 51% ettevõtte aktsiatest, ostis SEB Eesti Ühispangalt ka ülejäänud aktsiad ning plaanib ainuomanikuna investeerida puitplaaditööstusesse 200 miljonit krooni

  11. Sigma*-mediated electronic relaxation in 200nm photoexcited ammonia and heteroaromatics

    Directory of Open Access Journals (Sweden)

    Evans N. L.

    2013-03-01

    Full Text Available Time–resolved photoelectron spectra of ammonia display combination bands of the umbrella and stretching modes associated with the N–H coordinate of σ* relaxation. Time–resolved photodissociation studies determine timescales <200fs. Similar σ* photochemistry is found in heteroaromatics

  12. Shanghang 200,000 Tonnes Copper Smelting Project Speeds up The Pace of Construction

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    <正>The 200,000 tonnes copper smelting project of Zijin Copper Co.,Ltd with a total investment of 5 billion yuan is located in Shanghang Jiaoyang Circular Economy Industrial Park,since the start of construction in June last year,

  13. Strangelet search in S-W collisions at 200A GeV/c

    Science.gov (United States)

    Borer, K.; Dittus, F.; Frei, D.; Hugentobler, E.; Klingenberg, R.; Moser, U.; Pretzl, K.; Schacher, J.; Stoffel, F.; Volken, W.; Elsener, K.; Lohmann, K. D.; Baglin, C.; Bussière, A.; Guillaud, J. P.; Appelquist, G.; Bohm, C.; Hovander, B.; Selldèn, B.; Zhang, Q. P.

    1994-03-01

    A search for new massive particles with a low charge to mass ratio in S-W collisions at a beam momentum of 200 GeV/c per nucleon is presented. Upper limits for the production of strangelets with a mass to charge ratio of up to 60 GeV/c2 at rigidities of +/-150 GV are reported.

  14. Low-dose mifepristone 200 mg and vaginal misoprostol for abortion

    NARCIS (Netherlands)

    Schaff, EA; Eisinger, SH; Stadalius, LS; Franks, P; Gore, BZ; Poppema, S

    1999-01-01

    The objectives of this study were to determine the effectiveness, side effects, and acceptability of one-third the standard 600 mg dose of mifepristone (200 mg) to induce abortion. A prospective trial at seven sites enrolled women greater than or equal to 18 years, up to 8 weeks pregnant, and wantin

  15. 34 CFR 200.37 - Notice of identification for improvement, corrective action, or restructuring.

    Science.gov (United States)

    2010-07-01

    ... no later than 14 calendar days before, the start of the school year so that parents have adequate time to exercise their choice option before the school year begins. (5)(i) If the school is in its... Lea and School Improvement § 200.37 Notice of identification for improvement, corrective action,...

  16. Hainan’s 200,000-ton Uncoated Tinplate Base Project to Kick off

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    <正>Sources from NFC Hainan Nonferrous Metals Industry Co.,Ltd.indicated that,as a key project of Hainan,the 200,000-ton uncoated tinplate base project is expected to kick off in the first half of this year.Now,all preliminary works have been completed.Upon completion,

  17. 28 CFR 44.200 - Unfair immigration-related employment practices.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Unfair immigration-related employment... IMMIGRATION-RELATED EMPLOYMENT PRACTICES Prohibited Practices § 44.200 Unfair immigration-related employment practices. (a)(1) General. It is unfair immigration-related employment practice for a person or other...

  18. Optical studies of hydrogen above 200 gigapascals - Evidence for metallization by band overlap

    Science.gov (United States)

    Mao, N. K.; Hemley, R. J.

    1989-01-01

    Direct optical observations of solid hydrogen to pressures in the 250-gigapascal range at 77 K are reported. Hydrogen samples appear nearly opaque at the maximum pressures. Measurements of absorption and Raman spectra provide evidence that electronic excitations in the visible region begin at about 200 gigapascals. The optical data are consistent with a band-overlap mechanism of metallization.

  19. 梅科A-200:南非海军的新中坚

    Institute of Scientific and Technical Information of China (English)

    陈安刚

    2006-01-01

    今年2月16日,南非海军在西蒙斯顿举行仪式,宣布向德国订购的4艘梅科A-200轻型护卫舰的首舰“阿玛托拉”号正式入役。梅科A-200的加盟标志着南非海军进入了现代化发展阶段。梅科A-200是为满足南非海军的需求而设计的。该级舰使用了德国MEKO(由德文“多用选标准舰”一词各单词头一个字母耕成)新技术,其显著特点是:采用模块化技术设计,舰艇信号特征大为降低,海上生存能力强等。在南非海军现役舰艇中,现代化程度最高.打击火力最猛、技术性能最好者非梅科A-200莫属。梅科A-290轻型护卫舰可说是南非现代海军的中坚,令人关注。

  20. Study of the hadronic $\\gamma\\gamma$ interactions at $\\sqrt{s}$ = 200 GeV

    CERN Document Server

    Alderweireld, T; Verdier, P

    2000-01-01

    A comparison between real data and Monte Carlo is presented, based on a data sample corresponding to the 84.3 pb-1 recorded by the DELPHI detector in 1999, at centre-of-mass energy of 200 GeV. Two hadronic gamma gamma generators have been used for this present analysis, TWOGAM 2.04 and PYTHIA 6.143.

  1. miR-200 family controls late steps of postnatal forebrain neurogenesis via Zeb2 inhibition

    Science.gov (United States)

    Beclin, Christophe; Follert, Philipp; Stappers, Elke; Barral, Serena; Nathalie, Coré; de Chevigny, Antoine; Magnone, Virginie; Lebrigand, Kévin; Bissels, Ute; Huylebroeck, Danny; Bosio, Andreas; Barbry, Pascal; Seuntjens, Eve; Cremer, Harold

    2016-01-01

    During neurogenesis, generation, migration and integration of the correct numbers of each neuron sub-type depends on complex molecular interactions in space and time. MicroRNAs represent a key control level allowing the flexibility and stability needed for this process. Insight into the role of this regulatory pathway in the brain is still limited. We performed a sequential experimental approach using postnatal olfactory bulb neurogenesis in mice, starting from global expression analyses to the investigation of functional interactions between defined microRNAs and their targets. Deep sequencing of small RNAs extracted from defined compartments of the postnatal neurogenic system demonstrated that the miR-200 family is specifically induced during late neuronal differentiation stages. Using in vivo strategies we interfered with the entire miR-200 family in loss- and gain-of-function settings, showing a role of miR-200 in neuronal maturation. This function is mediated by targeting the transcription factor Zeb2. Interestingly, so far functional interaction between miR-200 and Zeb2 has been exclusively reported in cancer or cultured stem cells. Our data demonstrate that this regulatory interaction is also active during normal neurogenesis. PMID:27767083

  2. Radiation emission from the "Rhodotron-TT200" cavity

    Institute of Scientific and Technical Information of China (English)

    Farshid Tabbakh; Mahmud Borhani

    2011-01-01

    In this paper, the X-rays emitted from the Rhodotron-TT200 cavity have been studied in depth. We found that the Bremsstrahlung interaction is the only contribution of X-ray generation important to safety. The X-ray dose rate in the Rhodotron vault is calc

  3. Preparation and Dynamic Tensile Behavior of C200 Green Reactive Powder Concrete

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yunsheng; SUN Wei; LIU Sifeng; JIAO Chujie; LAI Jianzhong

    2006-01-01

    A new type of green reactive powder concrete (GRPC) with compressive strength of 200 MPa is prepared by utilizing composite mineral admixtures,natural fine aggregates,and short and fine steel fibers.The quasi-static mechanical properties (mechanical strength,toughness,fracture energy and interracial bonding strength) of GRPC specimens,cured in three different types of regimes,are investigated.The experimental results show that the mechanical properties of the C200 GRPC made with the powder binders that is composed of 40% of Portland cement,25% of ultra fine slag,25% of ultra fine fly ash and 10% of silica fume are better than the others'.The corresponding compressive strength,flexural strength and fracture energy are more than 200 MPa,and 30 000 J/m2 respectively.The dynamic tensile behavior of the C200 GRPC is also investigated through the split Hopkinson pressure bar (SHPB) according to the spalling phenomenon.The dynamic testing results demonstrate that strain rate has an important effect on the dynamic tensile behavior of GRPC.With the increase of strain rate,its peak stress and relevant strain increase.The GRPC exhibits an excellent strain ratio stiffening effect under the dynamic tensile Ioad with high strain ratio,resulting in a significant change of the fracture pattern.

  4. 33 CFR 157.200 - Plans for U.S. tank vessels: Submission.

    Science.gov (United States)

    2010-07-01

    ... CARRYING OIL IN BULK Dedicated Clean Ballast Tanks on Tank Vessels General § 157.200 Plans for U.S. tank... or documents that include the following: (1) The dedicated clean ballast tank arrangement. (2... dedicated clean ballast tanks, meets the stability standards for load line assignment in 46 CFR part 42....

  5. Sodium-dependent inhibition by PN200-110 enantiomers of nicotinic adrenal catecholamine release.

    Science.gov (United States)

    Cárdenas, A. M.; Montiel, C.; Artalejo, A. R.; Sánchez-García, P.; García, A. G.

    1988-01-01

    1. Dimethylphenylpiperazinium (DMPP) or high K concentrations evoke catecholamine release from perfused cat adrenal glands; in both cases the secretory response was significantly enhanced in the absence of Na. Tetrodotoxin did not modify the nicotinic secretory response. 2. The (+)- and (-)-enantiomers of the dihydropyridine Ca channel blocker PN200-110 show a high degree of stereoselectivity in the inhibition of catecholamine secretion evoked by high K or by DMPP in the presence of Na, the (+)-enantiomer being 57 and 80 times more potent, respectively, than the (-)-enantiomer. Both, noradrenaline and adrenaline release were equally depressed by PN200-110. 3. The IC50 values for (+)- and (-)-PN200-110 for blockade of the secretory response induced by K or DMPP in the presence of Na are in the same range. In the absence of Na, (-)-PN200-110 did not affect DMPP-evoked secretion; however, the (+)-enantiomer partially inhibited it. 4. The results suggest that the physiological catecholamine release from chromaffin cells is preceded by Na entry through the nicotinic receptor-associated ionophore; this causes cell depolarization, opening of voltage-dependent, dihydropyridine-sensitive Ca channels and Ca entry into the cell. In the absence of Na, additional Ca influx through an alternative pathway (the nicotinic cholinoceptor ionophore?) might also activate secretion. PMID:2975522

  6. Merelaevanduse erastamisega sai riik 200 miljoniga vastu pükse / Martin Hanson

    Index Scriptorium Estoniae

    Hanson, Martin, 1984-

    2006-01-01

    Ilmunud ka: Delovõje Vedomosti 28. juuni lk. 4-5. Eesti Merelaevanduse pankroti tõttu jääb Eesti riik ilma 200 miljonist kroonist. Vt. samas: Merelaevanduse kurbmäng; Sarnet: raha tulnuks kohe kätte nõuda; ESCO Shipping töötab edasi

  7. Increasing N200 Potentials Via Visual Stimulus Depicting Humanoid Robot Behavior.

    Science.gov (United States)

    Li, Mengfan; Li, Wei; Zhou, Huihui

    2016-02-01

    Achieving recognizable visual event-related potentials plays an important role in improving the success rate in telepresence control of a humanoid robot via N200 or P300 potentials. The aim of this research is to intensively investigate ways to induce N200 potentials with obvious features by flashing robot images (images with meaningful information) and by flashing pictures containing only solid color squares (pictures with incomprehensible information). Comparative studies have shown that robot images evoke N200 potentials with recognizable negative peaks at approximately 260 ms in the frontal and central areas. The negative peak amplitudes increase, on average, from 1.2 μV, induced by flashing the squares, to 6.7 μV, induced by flashing the robot images. The data analyses support that the N200 potentials induced by the robot image stimuli exhibit recognizable features. Compared with the square stimuli, the robot image stimuli increase the average accuracy rate by 9.92%, from 83.33% to 93.25%, and the average information transfer rate by 24.56 bits/min, from 72.18 bits/min to 96.74 bits/min, in a single repetition. This finding implies that the robot images might provide the subjects with more information to understand the visual stimuli meanings and help them more effectively concentrate on their mental activities.

  8. CHITINASE-B FROM SERRATIA-MARCESCENS-BJL200 IS EXPORTED TO THE PERIPLASM WITHOUT PROCESSING

    NARCIS (Netherlands)

    BRURBERG, MB; EIJSINK, VGH; HAANDRIKMAN, AJ; VENEMA, G; NES, IF

    1995-01-01

    A gene encoding a chitinase from Serratia marcescens BJL200 was cloned and expressed in Escherichia coli and S. marcescens. Nucleotide sequencing revealed an open reading frame encoding a 55.5 kDa protein of 499 amino acids without a typical signal peptide for export. The cellular localization of th

  9. Development program for a 200 kW, cw gyrotron. Final report

    Energy Technology Data Exchange (ETDEWEB)

    DeHope, W.J.; Ferguson, P.E.; Hart, S.L.; Matranga, V.A.; Sandoval, J.J.; Schmitt, M.J.; Tancredi, J.J.; Wozniak, M.A.

    1984-02-01

    Development of a millimeter-wave device to produce 200 kW of continuous wave power at 60 GHz is described. The device, a gyrotron oscillator, is intended for electron-cyclotron heating of fusion plasmas. The design philosophy is herein discussed and experimental results, both diagnostic and long pulse, are given.

  10. Step Frequency and Step Length of 200-m Sprint in Able-bodied and Amputee Sprinters.

    Science.gov (United States)

    Hobara, H; Sano, Y; Kobayashi, Y; Heldoorn, T A; Mochimaru, M

    2016-02-01

    The goal of this study was to examine the hypothesis that the difference in the 200-m sprint performance of amputee and able-bodied sprinters is due to a shorter step length rather than a lower step frequency. Men's elite-level 200-m races with a total of 16 able-bodied, 13 unilateral transtibial, 5 bilateral transtibial, and 16 unilateral transfemoral amputee sprinters were analyzed from publicly available internet broadcasts. For each run, the average forward velocity, step frequency, and step length over the entire 200-m distance were analyzed for each sprinter. The average forward velocity of able-bodied sprinters was faster than that of the other 3 groups, but there was no significant difference in average step frequency between able-bodied and transtibial amputee sprinters. However, the average step length of able-bodied sprinters was significantly longer than that of the transtibial amputee sprinters. In contrast, the step frequency and step length of transfemoral amputees were significantly lower and shorter than those of the other 3 groups. These results suggest that the differences in 200-m sprint performance between able-bodied and amputee sprinters are dependent on amputation level.

  11. North versus South : Energy transition and energy intensity in Europe over 200 years

    NARCIS (Netherlands)

    Gales, Ben; Kander, Astrid; Malanima, Paolo; Rubio, Mar

    2007-01-01

    This article examines energy consumption in Sweden, Holland, Italy and Spain over 200 years, including both traditional and modern energy carriers. The analysis is based on totally new series of energy consumption including traditional carriers along with modern sources. Our main purposes are a clos

  12. Euroopa Liit võtab Eestilt statistikaga 200 miljonit / Aivar Reinap

    Index Scriptorium Estoniae

    Reinap, Aivar, 1968-

    2004-01-01

    EL-i arvutusnõuete tõttu kasvas Eesti 2003. aasta SKP ligi 10 miljardi krooni võrra, mistõttu peab Eesti maksma igal aastal 200 miljoni võrra senisest rohkem liikmemaksu. Lisa: Pool miljardit lisaks

  13. Eesti Raudtee võib narvalaste vastuseisu tõttu kaotada 200 miljonit krooni / Irina Tokareva

    Index Scriptorium Estoniae

    Tokareva, Irina

    2005-01-01

    Ilmunud ka: Severnoje Poberezhje 29. apr. 2008, lk. 3, Narvskaja Nedelja 30. apr. lk. 3. Narva linnavolikogu kinnitas häälteenamusega Eesti Raudtee territooriumi detailplaneeringu. Kui otsus jõustub, võib ettevõte jätkata Narva teelõigu rekonstrueerimist, millele on juba ligi 200 miljonit krooni kulutatud

  14. 29 CFR 778.200 - Provisions governing inclusion, exclusion, and crediting of particular payments.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Provisions governing inclusion, exclusion, and crediting of... Provisions § 778.200 Provisions governing inclusion, exclusion, and crediting of particular payments. (a... statutory exclusions are authorized. It is important to determine the scope of these exclusions, since...

  15. Aulice to Build 1,200,000 Units/Y All- steel Tires Project

    Institute of Scientific and Technical Information of China (English)

    Li Zao

    2012-01-01

    To adapt to the rapid development of automobile industry and to meet the market demand on high- performance tires, upon investigation, Hubei Aulice Tire Co., Ltd. intends to build all-steel radial tire production project with the output of 1,200,000 units per year.

  16. 34 CFR 200.29 - Consolidation of funds in a schoolwide program.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Consolidation of funds in a schoolwide program. 200.29... Consolidation of funds in a schoolwide program. (a)(1) In addition to funds under subpart A of this part, a... IDEA for that fiscal year, divided by the number of children with disabilities in the jurisdiction...

  17. 24 CFR 200.158 - Applicability of Treasury regulations to debenture transactions.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Applicability of Treasury... Mortgage Insurance Procedures and Processing Claims for Losses § 200.158 Applicability of Treasury regulations to debenture transactions. The Department of the Treasury acts as fiscal agent for...

  18. 17 CFR 200.509 - Challenge to classification by Commission employees.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Challenge to classification by... COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Classification and Declassification of National Security Information and Material § 200.509 Challenge to classification by...

  19. 18 CFR 260.200 - Original cost statement of utility property.

    Science.gov (United States)

    2010-04-01

    ...), (2) the cost of the acquiring company, (3) the amount entered in the books as of the date of...) § 260.200 Original cost statement of utility property. Any natural gas company becoming subject to the... development of the company, including, particularly, a description (giving names of parties and dates) of...

  20. In de h200d : Een eigentijdse etnografie over de inbedding van criminaliteit en identiteit

    NARCIS (Netherlands)

    R.A. Roks (Robby)

    2016-01-01

    markdownabstractVanaf eind jaren tachtig van de vorige eeuw is er in Den Haag een groepering die zichzelf de Crips noemen, naar het voorbeeld van de van oorsprong uit Los Angeles afkomstige 'gang' The Crips. De Haagse Rollin 200 Crips hebben in de afgelopen decennia geregeld van zich laten horen in

  1. Hickory, N.C., Receives $200,000 EPA Brownfield Grants to Revitalize, Strengthen Local Economy

    Science.gov (United States)

    ATLANTA - At a press conference in Huntington, W.Va., today, the U.S. Environmental Protection Agency (EPA) announced a $200,000 Brownfields Area-Wide Planning (AWP) grant to the City of Hickory, N.C., for reuse planning that includes residential an

  2. 17 CFR 200.40 - Joint disposition of business by Commission meeting.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Joint disposition of business... EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Disposition of Commission Business § 200.40 Joint disposition of business by Commission meeting. Any meeting of...

  3. 17 CFR 200.42 - Disposition of business by seriatim Commission consideration.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Disposition of business by... EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Disposition of Commission Business § 200.42 Disposition of business by seriatim Commission consideration. (a) Whenever...

  4. 17 CFR 200.43 - Disposition of business by exercise of authority delegated to individual Commissioner.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Disposition of business by... Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Disposition of Commission Business § 200.43 Disposition of business by exercise of authority delegated...

  5. 46 CFR 174.200 - Damaged stability in machinery spaces for all OSVs.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Damaged stability in machinery spaces for all OSVs. 174... Vessels § 174.200 Damaged stability in machinery spaces for all OSVs. Each OSV must be shown by design... case of damage between any two watertight bulkheads in each machinery space....

  6. 34 CFR 200.64 - Factors for determining equitable participation of private school children.

    Science.gov (United States)

    2010-07-01

    ... amount of funds generated by private school children from low-income families under paragraph (a)(2) of... generated by children from low-income families under § 200.78 who attend that private school. (b) Services... from low-income families residing in participating public school attendance areas. (ii) The LEA......

  7. DESCRIPTION OF MODELING ANALYSES IN SUPPORT OF THE 200-ZP-1 REMEDIAL DESIGN/REMEDIAL ACTION

    Energy Technology Data Exchange (ETDEWEB)

    VONGARGEN BH

    2009-11-03

    The Feasibility Study/or the 200-ZP-1 Groundwater Operable Unit (DOE/RL-2007-28) and the Proposed Plan/or Remediation of the 200-ZP-1 Groundwater Operable Unit (DOE/RL-2007-33) describe the use of groundwater pump-and-treat technology for the 200-ZP-1 Groundwater Operable Unit (OU) as part of an expanded groundwater remedy. During fiscal year 2008 (FY08), a groundwater flow and contaminant transport (flow and transport) model was developed to support remedy design decisions at the 200-ZP-1 OU. This model was developed because the size and influence of the proposed 200-ZP-1 groundwater pump-and-treat remedy will have a larger areal extent than the current interim remedy, and modeling is required to provide estimates of influent concentrations and contaminant mass removal rates to support the design of the aboveground treatment train. The 200 West Area Pre-Conceptual Design/or Final Extraction/Injection Well Network: Modeling Analyses (DOE/RL-2008-56) documents the development of the first version of the MODFLOW/MT3DMS model of the Hanford Site's Central Plateau, as well as the initial application of that model to simulate a potential well field for the 200-ZP-1 remedy (considering only the contaminants carbon tetrachloride and technetium-99). This document focuses on the use of the flow and transport model to identify suitable extraction and injection well locations as part of the 200 West Area 200-ZP-1 Pump-and-Treat Remedial Design/Remedial Action Work Plan (DOEIRL-2008-78). Currently, the model has been developed to the extent necessary to provide approximate results and to lay a foundation for the design basis concentrations that are required in support of the remedial design/remediation action (RD/RA) work plan. The discussion in this document includes the following: (1) Assignment of flow and transport parameters for the model; (2) Definition of initial conditions for the transport model for each simulated contaminant of concern (COC) (i.e., carbon

  8. Feasibility study report for the 200-BP-1 operable unit. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-01

    This feasibility study (FS) examines a range of alternatives and provides recommendations for selecting a preferred altemative for remediating contamination at the 200-BP-1 operable unit. The 200-BP-1 operable unit is located in the center of the Hanford Site along the northern boundary of the 200 East Area. The 241-BY Tank Farm is located immediately to the south of the operable unit. 200-BP-1 is a source operable unit with contaminated soils associated primarily with nine inactive cribs (known as the 216-B cribs). These cribs were used for disposal of low-level radioactive liquid waste from U Plant uranium recovery operations, and waste storage tank condensate from the adjacent 241-BY Tank Farm. The cribs used for disposal of U Plant waste were in operation from 1955--1965, and the cribs used for disposal of tank condensate were in operation from 1965-1975. In addition to the cribs, four unplanned releases of radioactive materials have occurred within the operable unit. Contaminated surface soils associated with the unplanned releases have been consolidated over the cribs and covered with clean soil to reduce contaminant migration and exposure. Discharge of wastes to the cribs has resulted in soil and groundwater contamination. The groundwater is being addressed as part of the 200 East Aggregate Area groundwater operable unit. Contaminated soils at the site can be categorized by the types of contaminants, their distribution in the soil column, and the risk posed by the various potential exposure pathways. Below the clean soil cover, the near surface soils contain low-:levels of contamination with cesium-137, radium-226, strontium-90, thorium-228 and uranium. The lifetime incremental cancer risk associated with these soils if they were exposed at the surface is 9 {times} 10{sup 5}.

  9. Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility.

    Science.gov (United States)

    Choubey, Divaker

    2012-09-01

    Both genetic and environmental factors contribute to the development and progression of systemic lupus erythematosus (SLE), a complex autoimmune disease. The disease exhibits a strong gender bias and develops predominantly in females. Additionally, most SLE patients exhibit increased serum levels of interferon-α (IFN-α) and the "IFN signature". Studies using the mouse models of lupus have identified several lupus susceptibility loci, including the New Zealand Black (NZB)-derived autoimmunity 2 (Nba2) interval on the chromosome 1. The interval, which is syntenic to the human chromosome 1q region, harbors the FcγR family, SLAM/CD2-family, and the IFN-inducible Ifi200-family genes (encoding for the p200-family proteins). Studies involving the B6.Nba2 congenic mice revealed that the development of antinuclear autoantibodies (ANAs) depends on the age, gender, and activation of type I IFN-signaling. Interestingly, recent studies involving the generation of Nba2 subcongenic mouse lines and generation of mice deficient for the Fcgr2b or Aim2 gene within the interval have provided evidence that epistatic interactions among the Nba2 genes contribute to increased lupus susceptibility. Given that the expression of some of the p200-family proteins is differentially regulated by sex hormones and these proteins differentially regulate cytosolic DNA-induced production of type I IFN and proinflammatory cytokines (IL-1β and IL-18), the major known contributors of SLE-associated inflammation, we discuss the recent advancements in our understanding of the role of p200-family proteins in lupus susceptibility modification. An improved understanding of the role of p200-family proteins in the development of autoimmunity is likely to identify new approaches to treat SLE patients.

  10. Interferon-inducible Ifi200-family genes in systemic lupus erythematosus

    Science.gov (United States)

    Choubey, Divaker; Panchanathan, Ravichandran

    2008-01-01

    Systemic lupus erythematosus (SLE) is the prototype of complex autoimmune diseases. Studies have suggested that genetic, hormonal, and environmental factors contribute to the development of the disease. Interestingly, several recent studies involving SLE patients and mouse models of the disease have suggested a role for interferon (IFN)-stimulated genes (ISGs) in the development of SLE. One family of ISGs is the Ifi200-family, which includes mouse (Ifi202a, Ifi202b, Ifi203, Ifi204, and Ifi205) and human (IFI16, MNDA, AIM2, and IFIX) genes. The mouse genes cluster between serum amyloid P-component (Apcs) and α-spectrin (Spna-1) genes on chromosome 1 and the human genes cluster in syntenic region 1q23. The Ifi200-family genes encode structurally and functionally-related proteins (the p200-family proteins). Increased expression of certain p200-family proteins in cells is associated with inhibition of cell proliferation, modulation of apoptosis, and cell differentiation. Our studies involving generation of B6.Nba2 congenic mice, coupled with gene expression analyses, identified the Ifi202 as a candidate lupus-susceptibility gene. Importantly, recent studies using different mouse models of SLE have suggested that increased expression of Ifi202 gene (encoding p202 protein) in immune cells contributes to lupus susceptibility. Consistent with a functional role for the p202 protein in lupus susceptibility, increased levels of IFI16 protein in human SLE patients are associated with the diseases. This review summarizes recent findings concerning the regulation and role of p200-family proteins in the development of SLE. PMID:18598717

  11. 在狄更斯诞辰200周年致他的一封信%~. Letter to Charles Dickens on His 200^th Birthday

    Institute of Scientific and Technical Information of China (English)

    Claire Tomalin

    2012-01-01

    为什么我们还在读狄更斯?狄更斯的小说和戏剧,在他那个年代,就像今天的报纸和电视一样,总是第一时间报道穷街陋巷的新闻和传闻,关乎贫穷和慈悲,而这些故事,今天仍在不断上演。从某种意义上来说,狄更斯不仅生活在维多利亚时代,也生活在我们今天这个时代。在狄更斯诞辰200周年之际,《查尔斯狄更斯的一生》的作者用自己细腻的笔触带你走进狄更斯的世界。

  12. 200例成人社区获得性肺炎病原体研究%200 Cases of Adult Community-Acquired Pneumonia Pathogens Research

    Institute of Scientific and Technical Information of China (English)

    田占红

    2013-01-01

    Objective Through investigation and analysis of adult community-acquired pneumonia pathogens and pathogenic characteristics of the crowd,provide a basis for clinical treatment.Methods A retrospective analysis of our hospital in March 2010 to February 2012 period 200 cases of community-acquired pneumonia in patients with sputum culture and treatment of clinical data and the results were summarized.Results Information on a total of 200 cases,including 60 years of age were 30 cases,170 cases more than 60 years of age;to mostly elderly patients.Which cured 106 patients(53%),improved in 60 cases (30%) healed in 15 cases (7.5%),9 deaths(4.5%),10 patients left the hospital (5%).Status of sputum culture results showed that:sputum culture within 60 years as Vice mainly Haemophilus influenzae in 11 cases,36.7%.Patients over the age of 60 sputum culture results Haemophilus parainfluenzae in 68 cases,40%;results,mainly in patients with sputum culture Haemophilus parainfluenzae infection based.Conclusion Adult patients with community-acquired pneumonia,mostly elderly,Haemophilus parainfluenzae is a community-acquired pneumonia is one of the main pathogens.%  目的通过调查分析成人社区获得性肺炎致病人群及致病菌特点,为临床治疗提供依据。方法回顾性分析我院2010年3月~2012年2月期间200例社区获得性肺炎患者痰培养临床资料及治疗情况,并对结果进行总结。结果资料共200例,其中60岁以下者共30例,60岁以上者170例;以老年患者居多。其中治愈106例(53%),好转60例(30%),未愈15例(7.5%),9例死亡(4.5%),10例自动出院(5%)。痰培养结果状况显示:60岁以内的痰培养主要为副流感嗜血杆菌11例,36.7%。60岁以上患者痰培养结果显示副流感嗜血杆菌68例,占40%;结果显示,患者痰培养主要为副流感嗜血杆菌感染为主。结论成人社区获得性肺炎患者以老年人居多,副流感嗜血杆

  13. Some experience in management of 200 patients with facial trauma%面部外伤200例的治疗体会

    Institute of Scientific and Technical Information of China (English)

    李美兰; 魏军昌

    2003-01-01

    目的把面部外伤按美容方法手术,减少瘢痕形成,免除患者2次整容的痛苦.方法200例面部外伤均在LXD-型冷光显微手术灯下,用小三角针,细线分层对位缝合.结果伤口愈合良好,全部1期愈合,瘢痕少,不需2次手术.结论面部外伤,以美容手术方法缝合,是理想的处理方法.能取得良好的效果.

  14. 200个保健食品、食品宣传广告的调查%Survey on 200 Kinds of Functional Food and Advertisements

    Institute of Scientific and Technical Information of China (English)

    董东风; 李光宗

    2001-01-01

    @@ 保健食品、食品广告违法问题,已引起社会各界的强烈不满,近期已列为整顿和规范市场经济秩序工作的重要内容之一.保健食品、食品广告直接关系到广大人民群众的切身利益和生命安全,为从根本上制止违法的保健食品、食品广告,对某报发布的200个保健食品、食品广告进行了调查,针对保健食品、食品广告中存在的问题,提出改进意见.

  15. 200例主观性耳鸣患者听力损失临床分析%Study of hearing loss in 200 patients with subjective tinnitus

    Institute of Scientific and Technical Information of China (English)

    唐建辉; 吉彬; 刘立中

    2011-01-01

    目的:对耳鸣患者的听力损失进行分析,为进一步探讨耳鸣的发病原因、检查方法提供临床依据.方法:对以主观性耳鸣为主诉的200例患者进行耳科专科检查、声导抗检测、常频纯音听阈测听和高频扩展听阈测听检查.结果:200例耳鸣患者中,单侧耳鸣123例(61.5%),双侧耳鸣77例(38.5%);46例(23.0%)听力正常.单侧耳鸣中,患侧与对侧听阈比较0.125~8 kHz差异有统计学意义(P0.05).常频听力正常组与听力异常组比较各频率阈值差异均具有统计学意义(均P 10 kHz), the difference between two groups was not statistically significant (P > 0.05). There was significant difference in hearing threshold between tinnitus patients with normal and abnormal hearing in normal frequency(P<0. 05) ,meantime the detection rate in abnormal hearing group was lower than the normal group. Conclusion:Tinnitus can occur in people with normal hearing. Early in tinnitus,further study need be undertaken on whether the audiometry extended high frequency can offer the early evidence of hearing loss for tin-nitus patients or not.

  16. 200 Open Heart Operations on Patients with Ventricular Septal Defects%200例室间隔缺损(VSD)手术体会

    Institute of Scientific and Technical Information of China (English)

    李仲智; 郑德珍; 高玲; 郭志和; 高国庆; 陆进; 姜娟; 刘岚

    1989-01-01

    Two hundred open heart operations for VSD were performed between 1979.8 and 1987.5.77% of the patients aged below 5 years,and 68% weighed below 15kg and 16% below 10kg.98 out of 163(60%),on whom cardiac catherization was performed,showed moderate or severe pulmonary hypertension.197 patients su cvived,and 3 died duting hospitalization.Discussions involve:1) The age for operation.Patients with large defects and henrt failure;or repeated infection of respivatory tract,or hyposomia should be operated on earlier,better before the age of 2 years.As for patients with small defects operationts may be delayed to Presehool age.2) The type of operation.The defect with a diameter bigger than 1cm should be patched.The pladget mattress suture gives a better security sealing than the simple running suture does.3) The treatment of the associated cardiac deformities.PDA may be ligated before or after the cardiopulmonary bypass.4) The consi derations of a re-operation.Based on the experiences of 2 successful re-operations,it is suggested that in case of a serious complication responding Poorly to the medicaltreatmeat,a re-operation had better not be hesitated.%作者自1979年8月至1987年5月共进行了200例VSD心内直视手术,其中5岁以下占77%,体重15公斤以下占68%.手术取得良好的效果,存活率达到98.5%. 通过200例VSD手术经验,作者从手术时机的选择,修补方法的选择,合并畸形的处理以及再手术的决定等四个方面谈谈体会.

  17. 200名伤残荣誉军人牙周病调查分析%Investigation and anlysis of periodontal disease for 200 disabled soldiers

    Institute of Scientific and Technical Information of China (English)

    郭洁瑜; 李文利

    2013-01-01

    Objective: To understand the current situation of hospitalized disabled soldiers with periodontal disease, and explore the causes. Methods:Doctors-in-charge in Department of Stomatology examine 200 disabled soldiers with periodontal disease, enquire and record patients’ oral hygiene behaviors and bad habits. Results:The oral hygiene habit of disabled soldiers is worse. The prevalence rate of periodontitis is 59.5%, and the prevalence rate of gingivitis is 25.5%. Conclusion:The periodontal disease of hospitalized disabled soldiers is serious. We should strengthen the publicity of oral health knowledge, enhance the awareness of oral rights for disabled soldiers, and increase the initiative of protecting rights. Only in this way can the periodontal health level of disabled soldiers goes up radical y.%目的:了解住院伤残荣誉军人牙周病现状,并探索其形成原因。方法:由口腔科主治医师对200名伤残荣誉军人进行牙周病诊查,询问并记录患者的口腔卫生行为和不良嗜好。结果:伤残荣誉军人的口腔卫生习惯较差,牙周炎患病率为59.5%,牙龈炎的患病率为25.5%。结论:住院伤残荣誉军人牙周病严重,加强对其宣传口腔保健常识,增强伤残荣誉军人口腔维护意识,提高口腔维护的主动性,方可从根本上提高伤残荣誉军人的牙周健康水平。

  18. Lithium based alloy-thionyl chloride cells for applications at temperatures to 200 C

    Science.gov (United States)

    Kane, P.; Marincic, N.; Epstein, J.; Lindsey, A.

    A long-life lithium battery for industrial applications at temperatures up to 200 C was developed by combining Li-based alloy anodes with oxyhalide electrolytes. Cathodes were fabricated by rolling the blend of polycarbonomonofluoride, a conductive carbon additive, and a binder, while anodes were fabricated as those used in oxyhalide cells, incorporating a modified anode current collector designed to prevent the formation of 'lithium islands' at the end of discharge; nonwoven glass fiber separators were pretreated to remove excessive binders and lubricants. Various active electrode surface areas were combined with a corresponding thickness of electrodes and separators, matched in capacity. Tests of the high-rate electrode structure, using Li-Mg alloy anode in conjunction with thionyl chloride electrolyte, have demonstrated that the battery with this anode can be used under abusive conditions such as short circuit and external heating (at 175 C). Raising the operating temperature to 200 C did require some modifications of regular cell hardware.

  19. Groundwater impact assessment report for the 216-S-26 Crib, 200 West Area

    Energy Technology Data Exchange (ETDEWEB)

    Lindberg, J.W.; Evelo, S.D.; Alexander, D.J.

    1993-11-01

    This report assesses the impact of wastewater discharged to the 216-S-26 Crib on groundwater quality. The 216-S-26 Crib, located in the southern 200 West Area, has been in use since 1984 to dispose of liquid effluents from the 222-S Laboratory Complex. The 222-S Laboratory Complex effluent stream includes wastewater from four sources: the 222-S Laboratory, the 219-S Waste Storage Facility, the 222-SA Chemical Standards Laboratory, and the 291-S Exhaust Fan Control House and Stack. Based on assessment of groundwater chemistry and flow data, contaminant transport predictions, and groundwater chemistry data, the 216-S-26 Crib has minimal influence on groundwater contamination in the southern 200 West Area.

  20. Shrub-inhabiting insects of the 200 Area Plateau, southcentral Washington.

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, L.E.

    1979-10-01

    This study characterizes the insects (including spiders) associated with major shrubs of the 200 Area Plateau on the Hanford Site in southcentral Washington. Big sagebrush (Artemisia tridentata), rabbitbrush (Chrysothamnus sp.) and hopsage (Grayia spinosa) were the three shrubs included in the study. Hemiptera (true bugs) and homoptera (bugs) were the two groups most abundant on sagebrush. Homoptera and Araneida (spiders) were the common inhabitants of rabbitbrush, and Orthoptera (grasshoppers), Coleoptera (beetles), and Araneida the taxa most frequently collected from hopsage. A discussion of the effects of insects on western native shrubs is included. None of the insect populations appeared to threaten the stability of shrub stands, which is important because of the erodability of 200 Area soils.

  1. Assessing personality change in psychotherapy with the SWAP-200: a case study.

    Science.gov (United States)

    Lingiardi, Vittorio; Shedler, Jonathan; Gazzillo, Francesco

    2006-02-01

    Many studies document the efficacy of psychotherapy for acute syndromes such as depression, but less is known about personality change in patients treated for personality pathology. The Shedler-Westen Assessment Procedure (SWAP-200; Westen & Shedler, 1999a, 1999b) is an assessment tool that measures a broad spectrum of personality constructs and is designed to bridge the gap between the clinical and empirical traditions in personality assessment. In this article, we demonstrate the use of the SWAP-200 as a measure of change in a case study of a patient diagnosed with borderline personality disorder. We collected assessment data at the start of treatment and after 2 years of psychotherapy. The findings illustrate the personality processes targeted in intensive psychotherapy for borderline personality.

  2. COMBINED TREATMENT OF 200CASES OF PERIPHERY FACIAL PARALYSIS WITH ACUPUNCTURE AND CHINESE MEDICINAL HERBS

    Institute of Scientific and Technical Information of China (English)

    LuoHeping

    2000-01-01

    In the present study,200cases of periphery facial paralysis were treated with combined therapies of handle needle,electroacupuncture(EA),electronic moxibustion and oral administration of Supplemented Qianzheng San.After treatment,of the200cases,176were cured,15had marked im-provement and 9had improvement.Two groups of acupoints were chosen and used alternately for keeping the excitement of acupoints,preventing acupoint fatigue and raising the therapeutic effect.In the acute stage of periphery facial palsy,acupuncture treatment was performed using shallow needing,mild manipulation and no needing penetration.In the convalescence stage and sequela stage,penetra-tion needling was adopted and stronger stimulation given.During acute period and when facial muscu-lar spasm appeared,EA stimulation was not suitable for facial acupoints.Over use of vision should be avoided.

  3. Cryogenic Tests of Volume-Phase Holographic Gratings: I. Results at 200 K

    CERN Document Server

    Tamura, N; Luke, P N; Blackburn, C; Robertson, D J; Dipper, N A; Sharples, R M; Allington-Smith, J R; Tamura, Naoyuki; Murray, Graham J.; Luke, Peter; Blackburn, Colin; Robertson, David J.; Dipper, Nigel A.; Sharples, Ray M.; Allington-Smith, Jeremy R.

    2003-01-01

    We present results from cryogenic tests of a Volume-Phase Holographic (VPH) grating at 200 K measured at near-infrared wavelengths. The aims of these tests were to see whether the diffraction efficiency and angular dispersion of a VPH grating are significantly different at a low temperature from those at a room temperature, and to see how many cooling and heating cycles the grating can withstand. We have completed 5 cycles between room temperature and 200 K, and find that the performance is nearly independent of temperature, at least over the temperature range which we are investigating. In future, we will not only try more cycles between these temperatures but also perform measurements at a much lower temperature (e.g., 80 K).

  4. Beam profile measurement of ES-200 using secondary electron emission monitor

    Directory of Open Access Journals (Sweden)

    E Ebrahimi Basabi

    2015-09-01

    Full Text Available Up to now, different designs have been introduced for measurement beam profile accelerators. Secondary electron emission monitors (SEM are one of these devices which have been used for this purpose. In this work, a SEM has been constructed to measure beam profile of ES-200 accelerator, a proton electrostatic accelerator which is installed at SBU. Profile grid for both planes designed with 16 wires which are insulated relative to each other. The particles with maximum energy of 200 keV and maximum current of 400 μA are stopped in copper wires. Each of the wires has an individual current-to-voltage amplifier. With a multiplexer, the analogue values are transported to an ADC. The ADCs are read out by a microcontroller and finally profile of beam shows by a user interface program

  5. Treatment of 200 Cases of Asthma by Fat-cut Therapy

    Institute of Scientific and Technical Information of China (English)

    ZHANG Su-ya

    2005-01-01

    After local anesthesia, the skin of Shanzhong (CV 17) was incised 2 cm in length to expose the subcutaneous fat fully, and after cutting away local fat, the handle of the forceps was used inside the incision directly for stimulation and then the incision was sutured. In 200 cases of asthma patients, 100 cases were cured, and 95 cases were improved and 5 cases failed, with the effective rate in 97.5%.%取膻中穴,局部麻醉后,切开皮肤2cm,充分暴露皮下脂肪.割去局部脂肪在切口内直接用镊柄作手法刺激,然后缝合伤口.200例哮喘患者中治愈100例,好转95例,无效5例,总有效率97.5%.

  6. Summary of radioactive solid waste received in the 200 areas during calendar year 1997

    Energy Technology Data Exchange (ETDEWEB)

    Hagel, D.L.

    1998-06-25

    Waste Management Federal Services of Hanford Inc. manages and operates the Hanford Site 200 Area radioactive solid waste storage and disposal facilities for the US Department of Energy, Richland Operations Office under contract DE-AC06-87RL10930. These facilities include storage areas and disposal sites for radioactive solid waste. This document summarizes the amount of radioactive materials that have been buried and stored in the 200 Area radioactive solid waste storage and disposal facilities from startup in 1944 through calendar year 1997. This report does not include backlog waste, solid radioactive wastes in storage or disposed of in other areas, or facilities such as the underground tank farms. Unless packaged within the scope of WHC-EP-0063, Hanford Site Solid Waste Acceptance Cafeteria, liquid waste data are not included in this document.

  7. Summary of radioactive solid waste received in the 200 areas during calendar year 1996

    Energy Technology Data Exchange (ETDEWEB)

    Hladek, K.L.

    1997-05-21

    Rust Federal Services of Hanford Inc. manages and operates the Hanford Site 200 Area radioactive solid waste storage and disposal facilities for the US Department of Energy, Richland Operations Office under contract DE-AC06-87RL10930. These facilities include storage areas and disposal sites for radioactive solid waste. This document summarizes the amount of radioactive materials that have been buried and stored in the 200 Area radioactive solid waste storage and disposal facilities from startup in 1944 through calendar year 1996. This report does not include backlog waste, solid radioactive wastes in storage or disposed of in other areas, or facilities such as the underground tank farms. Unless packaged within the scope of WHC-EP-0063, Hanford Site Solid Waste Acceptance Criteria, liquid waste data are not included in this document.

  8. Summary of radioactive solid waste received in the 200 Areas during calendar year 1994

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, J.D.; Hagel, D.L.

    1995-08-01

    Westinghouse Hanford Company manages and operates the Hanford Site 200 Area radioactive solid waste storage and disposal facilities for the US Department of Energy, Richland Field Office, under contract DE-AC06-87RL10930. These facilities include radioactive solid waste disposal sites and radioactive solid waste storage areas. This document summarizes the amount of radioactive material that has been buried and stored in the 200 Area radioactive solid waste storage and disposal facilities from startup in 1944 through calendar year 1994. This report does not include backlog waste: solid radioactive wastes in storage or disposed of in other areas or facilities such as the underground tank farms. Unless packaged within the scope of WHC-EP-0063, Hanford Site Solid Waste Acceptance Criteria (WHC 1988), liquid waste data are not included in this document.

  9. NASA Green Flight Challenge: Conceptual Design Approaches and Technologies to Enable 200 Passenger Miles per Gallon

    Science.gov (United States)

    Wells, Douglas P.

    2011-01-01

    The Green Flight Challenge is one of the National Aeronautics and Space Administration s Centennial Challenges designed to push technology and make passenger aircraft more efficient. Airliners currently average around 50 passenger-miles per gallon and this competition will push teams to greater than 200 passenger-miles per gallon. The aircraft must also fly at least 100 miles per hour for 200 miles. The total prize money for this competition is $1.65 Million. The Green Flight Challenge will be run by the Comparative Aircraft Flight Efficiency (CAFE) Foundation September 25 October 1, 2011 at Charles M. Schulz Sonoma County Airport in California. Thirteen custom aircraft were developed with electric, bio-diesel, and other bio-fuel engines. The aircraft are using various technologies to improve aerodynamic, propulsion, and structural efficiency. This paper will explore the feasibility of the rule set, competitor vehicles, design approaches, and technologies used.

  10. The CO poisoning effect in PEMFCs operational at temperatures up to 200 degrees C

    DEFF Research Database (Denmark)

    Li, Qingfeng; He, Ronghuan; Gao, Ji-An;

    2003-01-01

    The CO poisoning effect on carbon-supported platinum catalysts (at a loading of 0.5 mg Pt/cm(2) per electrode! in polymer electrolyte membrane fuel cells (PEMFCs) has been investigated in a temperature range from 125 to 200 degreesC with the phosphoric acid-doped polybenzimidazole membranes...... as electrolyte. The effect is very temperature-dependent and can be sufficiently suppressed at elevated temperature. By defining the CO tolerance as a voltage loss less than 10 mV, it is evaluated that 3% CO in hydrogen can be tolerated at current densities up to 0.8 A/cm(2) at 200 degreesC, while at 125 degrees...

  11. Current exposure of 200 pregnant Danish women to phthalates, parabens and phenols

    DEFF Research Database (Denmark)

    Tefre de Renzy-Martin, Katrine; Frederiksen, Hanne; Christensen, Jeppe Hagstrup

    2014-01-01

    Many phthalates, parabens and phenols are suspected to have endocrine disrupting properties in humans. They are found in consumer products, including food wrapping, cosmetics and building materials. The foetus is vulnerable and exposure to these chemicals is of particular concern for pregnant women....... We therefore studied current exposure to several commonly used phthalates, parabens and phenols in 200 healthy, pregnant Danish women. A total of 200 spot urine samples were collected between weeks 8-30 of pregnancy and analysed for 10 phenols, 7 parabens and 16 phthalate metabolites by LC...... daily intake (TDI) and with Hazard Quotients (HQ) below 1. In conclusion, we found detectable levels of phthalate metabolites, parabens and phenols in almost all pregnant women, suggesting combined multiple exposures. Although the individual estimated DI of phthalates and BPA was below TDI, our results...

  12. Relativistic analysis of nuclear ground state densities at 135 to 200 MeV

    Indian Academy of Sciences (India)

    M A Suhail; N Neeloffer; Z A Khan

    2005-12-01

    A relativistic analysis of p + 40Ca elastic scattering with different nuclear ground state target densities at 135 to 200 MeV is presented in this paper. It is found that the IGO densities are more consistent in reproducing the data over the energy range considered here. The reproduction of spin-rotation-function data with the simultaneous fitting of differential cross-section and analyzing power, and the appearance of wine-bottle-bottom shaped Re eff() in the transition energy region, sensitively depends on the input nuclear ground state densities and are not solely the relativistic characteristic signatures. We also found that the wine-bottle-bottom shaped Re eff() is preferred by the spin observables in the transition energy region (i.e. 181 MeV to 200 MeV).

  13. Hydrogeology of the Hanford Site Central Plateau – A Status Report for the 200 West Area

    Energy Technology Data Exchange (ETDEWEB)

    Last, George V.; Thorne, Paul D.; Horner, Jacob A.; Parker, Kyle R.; Bjornstad, Bruce N.; Mackley, Rob D.; Lanigan, David C.; Williams, Bruce A.

    2009-08-27

    The Remediation Decisions Support (RDS) function of the Soil and Groundwater Remediation Project (managed by CH2M HILL Plateau Remediation Company [CHPRC]) is responsible for facilitating the development of consistent data, parameters, and conceptual models to resolve technical issues and support efforts to estimate contaminant migration and impacts (i.e., the assessment process). In particular, the RDS function is working to update electronic data sources and conceptual models of the geologic framework and associated hydraulic and geochemical parameters to facilitate traceability, transparency, defensibility, and consistency in support of environmental assessments. This report summarizes the efforts conducted by Pacific Northwest National Laboratory (PNNL) scientists in fiscal year 2008 (FY08) that focused primarily on the 200 West Area, as well as a secondary effort initiated on the 200 East Area.

  14. miR-200b Suppresses Cell Growth, Migration and Invasion by Targeting Notch1 in Nasopharyngeal Carcinoma

    Directory of Open Access Journals (Sweden)

    Xu Yang

    2013-11-01

    Full Text Available Background/Aims: MicroRNAs (miRNAs are a class of small noncoding RNA molecules that play important roles in carcinogenesis and tumor progression. We investigated the roles and mechanisms of miR-200b in human nasopharyngeal carcinoma (NPC. Methods: We used quantitative real-time polymerase chain reaction (qRT-PCR analyses to measure levels of miR-200b and Notch1 in NPC specimens and cell lines. Human NPC cell lines stably expressing miR-200b or control were used to analyze the tumour-suppressive effect of miR-200b. Luciferase reporter assays were used to determine the association between miR-200b and the Notch1 3' untranslated region. Results: We found that miR-200b is significantly downregulated in NPC tissues and cell lines. Gain-of-function and loss-of-function studies demonstrated that miR-200b suppresses NPC cell growth, migration and invasion in vitro. Importantly, overexpression of miR-200b effectively repressed tumor growth in nude mouse models. Integrated analysis identified Notch1 as a direct and functional target of miR-200b. Overexpression of Notch1 reversed the inhibitory effect of miR-200b on NPC cell growth and invasion. Conclusion: These results indicate that miR-200b exerts tumor-suppressive effects in NPC carcinogenesis through the suppression of Notch1 expression and suggest a therapeutic application of miR-200b in NPC.

  15. Anti-p200 pemphigoid (anti-laminin-γ1 pemphigoid demonstrating pathergy

    Directory of Open Access Journals (Sweden)

    Morgan McCarty, DO

    2015-12-01

    Full Text Available Anti-p200 pemphigoid, also called anti-laminin-γ1 pemphigoid, is a recently defined entity. First reported in 1996, the incidence is relatively rare, with approximately 70 reports in the literature. Clinical presentation is heterogeneous, but the disease most commonly mimics bullous pemphigoid with urticarial papules, plaques, or tense bullae on the trunk or extremities. Described here is a case with additional features of pathergy that have not yet been reported in the literature.

  16. Systematic Study of Trace Radioactive Impurities in Candidate Construction Materials for EXO-200

    Energy Technology Data Exchange (ETDEWEB)

    Leonard, D.S.; Grinberg, P.; Weber, P.; Baussan, E.; Djurcic, Z.; Keefer, G.; Piepke, A.; Pocar, A.; Vuilleumier, J.-L.; Vuilleumier, J.-M.; Akimov, D.; Bellerive, A.; Bowcock, M.; Breidenbach, M.; Burenkov, A.; Conley, R.; Craddock, W.; Danilov, M.; DeVoe, R.; Dixit, M.; Dolgolenko, A.; /Alabama U. /NRC-INMS /Neuchatel U. /Stanford U., Phys. Dept. /SLAC /Colorado State U. /Laurentian U. /Maryland U. /UC, Irvine

    2007-10-24

    The Enriched Xenon Observatory (EXO) will search for double beta decays of 136Xe. We report the results of a systematic study of trace concentrations of radioactive impurities in a wide range of raw materials and finished parts considered for use in the construction of EXO-200, the first stage of the EXO experimental program. Analysis techniques employed, and described here, include direct gamma counting, alpha counting, neutron activation analysis, and high-sensitivity mass spectrometry.

  17. Fundamental Frequency Tuning and Its Influence on LHC 200MHz ACN Cavity

    CERN Document Server

    Linnecar, Trevor Paul R; Tückmantel, Joachim; CERN. Geneva. SPS and LHC Division

    2001-01-01

    To study the influence of the tuner on the fundamental mode frequency, the Q factor as well as the shunt impedance of the LHC 200MHz ACN cavities, 3D simulations have been done in the frequency domain using MAFIA. Curves giving the variation of RF frequency and other RF parameters with tuner position relative to the inner surface of the cavity have been obtained for the fundamental mode. This paper details the simulation results.

  18. 200例前置胎盘的护理体会

    Institute of Scientific and Technical Information of China (English)

    刘铁华

    2014-01-01

    目的:分析临床上在前置胎盘孕妇护理过程中应该注意的事项,总结出最佳的护理措施。方法通过对我院200例前置胎盘患者同期传统护理方法对比。结果200例患者中,院内发生母婴死亡率为0,明显低于同期采取传统护理方法孕妇母婴死亡率0.72%。结论加强对前置胎盘的认识,严密观察患者生命体征,采取及时、有效、合理的护理措施对于提高前置胎盘治疗效果、保证产妇和新生儿平安具有重要作用。%Objective To analyze the clinical issues in the course of care for pregnant women with placenta previa should be noted,summed best care measures.Methods By comparing our hospital 200 cases over the same period of traditional methods of care patients with placenta previa.Results 200 patients,the occurrence of maternal and child hospital mortality was 0,significantly lower than that of traditional methods of care for pregnant women to take maternal mortality rate of 0.72%.Conclusion Strengthen awareness of placenta previa,close observation of vital signs,take timely,effective and reasonable care measures for improving the therapeutic effect of placenta previa,maternal and neonatal ensure safe play an important role.

  19. 索尼DSC-P200数码相机

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    作为面向普通家用的时尚主打机型,索尼DSC-P系列一直保持着相当高的市场份额,在DSC-P150把家用数码相机带到700万像素级后,索尼继续推出了DSC-P150的升级机型DSC-P200

  20. The prevalence of periodontal disease in a Romano-British population c. 200-400 AD

    OpenAIRE

    2014-01-01

    Objective The aim of this study was to investigate the prevalence of moderate to severe periodontitis in an ancient British cohort c. 200-400 AD. Design Observational study to assess periodontal and other oral disease parameters. Setting Natural History Museum, London. Subjects and methods 303 skulls from a Romano-British burial site in Poundbury, Dorset were examined for evidence of dental disease. Main outcome measures The primary outcome measure was presence of moderate to severe periodont...

  1. Strangelet search in S-W collisions at 200[ital A] GeV/[ital c

    Energy Technology Data Exchange (ETDEWEB)

    Borer, K.; Dittus, F.; Frei, D.; Hugentobler, E.; Klingenberg, R.; Moser, U.; Pretzl, K.; Schacher, J.; Stoffel, F.; Volken, W. (Laboratory for High Energy Physics, University of Bern, CH-3012 Bern (Switzerland)); Elsener, K.; Lohmann, K.D. (CERN, CH-1211 Geneva (Switzerland)); Baglin, C.; Bussiere, A.; Guillaud, J.P. (Laboratoire de Physique des Particules, CNRS-Institut National de Physique Nucleaire et de Physique des Particules, F-74019 Annecy-le-Vieux (France)); Appelquist, G.; Bohm, C.; Hovander, B.; Sellden, B.; Zhang, Q.P. (Fysikum, Stockholm University, Box 6730, S-113 85 Stockholm (Sweden))

    1994-03-07

    A search for new massive particles with a low charge to mass ratio in S-W collisions at a beam momentum of 200 GeV/[ital c] per nucleon is presented. Upper limits for the production of strangelets with a mass to charge ratio of up to 60 GeV/[ital c][sup 2] at rigidities of [plus minus]150 GV are reported.

  2. Strangelet search in S-W collisons at 200 {A·GeV}/{c}

    Science.gov (United States)

    Appelquist, G.; Baglin, C.; Bohm, C.; Borer, K.; Bussière, A.; Elsener, K.; Dittus, F.; Frei, D.; Guillaud, J. P.; Hovander, B.; Klingenberg, R.; Lohmann, K. D.; Hugentobler, E.; Moser, U.; Pretzl, K.; Schacher, J.; Selldèn, B.; Stoffel, F.; Volken, W.; Zhang, Q. P.

    1994-01-01

    We have searched for new massive particles with a low charge to mass ratio in S -W collisions at a beam momentum of 200 {GeV}/{c} per nucleon. Upper limits for the production of strangelets with a mass to charge ratio up to 60 {GeV}/{c 2} at rigidities of ± 150 GV are reported. This study was done with a test setup using as a spectrometer the H 6-beamline in the north area at CERN.

  3. Upgrade of Tuning-position Display for SFC 200 kW Transmitter Anode Circuit

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    It is necessary to display of precise position of anode plate tuning device for 200 kW transmitter.Therefore parameters can be conveniently preset in different frequency to tealize frequency replacing and impedance matching of D-circuit.Photo-electricity coding was originally used for angle position of old system.But after ten years’operation,it can’t precisely display position of circuit element movement because its grating was

  4. MiR-200c Regulates Noxa Expression and Sensitivity to Proteasomal Inhibitors

    OpenAIRE

    2012-01-01

    The pro-apoptotic p53 target Noxa is a BH3-only protein that antagonizes the function of selected anti-apoptotic Bcl-2 family members. While much is known regarding the transcriptional regulation of Noxa, its posttranscriptional regulation remains relatively unstudied. In this study, we therefore investigated whether Noxa is regulated by microRNAs. Using a screen combining luciferase reporters, bioinformatic target prediction analysis and microRNA expression profiling, we identified miR-200c ...

  5. Recubrimientos ópticos en el rango espectral entre 50 y 200 nm

    OpenAIRE

    Fernández Perea, Mónica; Méndez, José Antonio; Larruquert, Juan Ignacio; Aznárez, José Antonio

    2006-01-01

    The development of efficient optical coatings in the spectral region between 50 and 200 nm (EUV-FUV) is an important challenge due to the great absortion and low reflectance that most of the materials present in this region. In addition, these coatings are an important element in the advance of many fields like astronomical abservations, plasma diagnosis and lithography. In this work we describe some of the optical coatings developed by the Research Group in Thin Film Coatings (GOLD), whic...

  6. A 200 MHz SC-RF System for the HL-LHC

    CERN Document Server

    Calaga, Rama

    2016-01-01

    A quarter wave β=1 superconducting cavity at 200 MHz is proposed for the LHC as an alternative to the present 400 MHz RF system. The primary motivation of such a system would be to accelerate higher intensity and longer bunches with improved capture efficiency. Advantages related to minimizing electron cloud effects, intra-beam scattering, heating and the possibility of luminosity levelling with bunch length are described. Some considerations related to cavity optimization, beam loading and technological challenges are addressed.

  7. 200 TW 45 fs laser based on optical parametric chirped pulse amplification.

    Science.gov (United States)

    Lozhkarev, V V; Freidman, G I; Ginzburg, V N; Katin, E V; Khazanov, E A; Kirsanov, A V; Luchinin, G A; Mal'shakov, A N; Martyanov, M A; Palashov, O V; Poteomkin, A K; Sergeev, A M; Shaykin, A A; Yakovlev, I V; Garanin, S G; Sukharev, S A; Rukavishnikov, N N; Charukhchev, A V; Gerke, R R; Yashin, V E

    2006-01-01

    200 TW peak power has been achieved experimentally using a Cr:forsterite master oscillator at 1250 nm, a stretcher, three optical parametrical amplifiers based on KD*P (DKDP) crystals providing 14.5 J energy in the chirped pulse at 910 nm central wavelength, and a vacuum compressor. The final parametrical amplifier and the compressor are described in detail. Scaling of such architecture to multipetawatt power is discussed.

  8. 震撼未来 富士FinePixF200EXR相机

    Institute of Scientific and Technical Information of China (English)

    陈超; 张斌(摄影)

    2009-01-01

    “创新,改变世界”,中国联通的广告词放在富士(FUJIFILM)FinePixF200EXR数码相机身上似乎也很合适,其搭载的全新一代Super CCD EXR传感器。宣称具有革命性意义。并将开启传感新纪元。

  9. S7-200PLC与三菱FX系列PLC的自由口通信

    Institute of Scientific and Technical Information of China (English)

    杨峰

    2013-01-01

    PLC是工业控制现场应用较为广泛的一种控制器,现场工位上可能使用不同厂家生产的PLC,各种PLC都有自己的通信协议.本文主要介绍了S7-200系列PLC与三菱FX系列PLC的自由口通信.

  10. RESULTS FROM PP AT 62.4 AND 200 GeV WITH THE BRAHMS EXPERIMENTATION.

    Energy Technology Data Exchange (ETDEWEB)

    VIDEBAEK,F.; (BRAHMS EXPERIMENTATION)

    2007-02-11

    Measurements of elementary pp collisions are essential for understanding heavy ion collisions. R.esu1ts for pp collisions at 200 and 62.4 GeV are presented. At both energies NLO pQCD describes pion production well. The measured pion transverse single spin asymmetries are very large at 62.4 GeV and are reasonably well described by models relying on pQCD at transverse momenta larger than 1 GeV/c.

  11. Swept source OCT imaging of human anterior segment at 200 kHz

    Science.gov (United States)

    Karnowski, Karol; Gora, Michalina; Kaluzny, Bartlomiej; Huber, Robert; Szkulmowski, Maciej; Kowalczyk, Andrzej; Wojtkowski, Maciej

    2009-02-01

    We present applicability of the high speed swept-source optical coherence tomography for in vivo imaging of the anterior segment of the human eye. Three dimensional imaging of the cornea with reduced motion artifacts is possible by using swept source with Fourier domain mode locking operating at 200kHz with 1300nm central wavelength. High imaging speeds allow for assessment of anterior and posterior corneal topography and generation of thickness and elevation maps.

  12. Analysis and decision document in support of acquisition of steam supply for the Hanford 200 Area

    Energy Technology Data Exchange (ETDEWEB)

    Brown, D.R.; Daellenbach, K.K.; Hendrickson, P.L.; Kavanaugh, D.C.; Reilly, R.W.; Shankle, D.L.; Smith, S.A.; Weakley, S.A.; Williams, T.A. [Pacific Northwest Lab., Richland, WA (United States); Grant, T.F. [Battelle Human Affairs Research Center, Seattle, WA (United States)

    1992-02-01

    The US Department of Energy (DOE) is now evaluating its facility requirements in support of its cleanup mission at Hanford. One of the early findings is that the 200-Area steam plants, constructed in 1943, will not meet future space heating and process needs. Because the 200 Area will serve as the primary area for waste treatment and long-term storage, a reliable steam supply is a critical element of Hanford operations. This Analysis and Decision Document (ADD) is a preliminary review of the steam supply options available to the DOE. The ADD contains a comprehensive evaluation of the two major acquisition options: line-term versus privatization. It addresses the life-cycle costs associated with each alternative, as well as factors such as contracting requirements and the impact of market, safety, security, and regulatory issues. Specifically, this ADD documents current and future steam requirements for the 200 Area, describes alternatives available to DOE for meeting these requirements, and compares the alternatives across a number of decision criteria, including life-cycle cost. DOE has currently limited the ADD evaluation alternatives to replacing central steam plants rather than expanding the study to include alternative heat sources, such as a distributed network of boilers or heat pumps. Thirteen project alternatives were analyzed in the ADD. One of the alternatives was the rehabilitation of the existing 200-East coal-fired facility. The other twelve alternatives are combinations of (1) coal- or gas-fueled plants, (2) steam-only or cogeneration facilities, (3) primary or secondary cogeneration of electricity, and (4) public or private ownership.

  13. Magnetohydrodynamics (MHD) Engineering Test Facility (ETF) 200 MWe power plant. Design Requirements Document (DRD)

    Science.gov (United States)

    Rigo, H. S.; Bercaw, R. W.; Burkhart, J. A.; Mroz, T. S.; Bents, D. J.; Hatch, A. M.

    1981-01-01

    A description and the design requirements for the 200 MWe (nominal) net output MHD Engineering Test Facility (ETF) Conceptual Design, are presented. Performance requirements for the plant are identified and process conditions are indicated at interface stations between the major systems comprising the plant. Also included are the description, functions, interfaces and requirements for each of these major systems. The lastest information (1980-1981) from the MHD technology program are integrated with elements of a conventional steam electric power generating plant.

  14. GTCP331-200型APU引气系统工作原理介绍

    Institute of Scientific and Technical Information of China (English)

    盛杰

    2010-01-01

    @@ 1.APU主要功能介绍 1.1我公司所选APU的基本情况 APU的中文名称为辅助动力装置,一般都安装在飞机的尾部.我公司所选的APU是由Garrett(盖瑞特)公司设计生产的GTCP 331-200型.

  15. In de h200d: Een eigentijdse etnografie over de inbedding van criminaliteit en identiteit

    OpenAIRE

    Roks, Robby

    2016-01-01

    markdownabstractVanaf eind jaren tachtig van de vorige eeuw is er in Den Haag een groepering die zichzelf de Crips noemen, naar het voorbeeld van de van oorsprong uit Los Angeles afkomstige 'gang' The Crips. De Haagse Rollin 200 Crips hebben in de afgelopen decennia geregeld van zich laten horen in de media, onder andere in actualiteitenprogramma’s, in tijdschriften, een boek en een documentaire. In dit etnografische onderzoek naar de inbedding van criminaliteit en identiteit wordt bezien hoe...

  16. BRCA mutations cause reduction in miR-200c expression in triple negative breast cancer.

    Science.gov (United States)

    Erturk, Elif; Cecener, Gulsah; Tezcan, Gulcin; Egeli, Unal; Tunca, Berrin; Gokgoz, Sehsuvar; Tolunay, Sahsine; Tasdelen, Ismet

    2015-02-10

    Triple negative breast cancer (TNBC) is the most aggressive and poorly understood subclass of breast cancer (BC). Over the recent years, miRNA expression studies have been providing certain detailed overview that aberrant expression of miRNAs is associated with TNBC. Although TNBC tumors are strongly connected with loss of function of BRCA genes, there is no knowledge about the effect of BRCA mutation status on miRNA expressions in TNBC cases. The aims of this study were to evaluate the expression profile of miRNAs that plays role in TNBC progression and the role of BRCA mutations in their regulation. The expression level of BC associated 13 miRNAs was analyzed in 7 BRCA mutations positive, 6 BRCA mutations negative TNBC cases and 20 non-tumoral tissues using RT-PCR. According to RT2 Profiler PCR Array Data Analysis, let-7a expression was 4.67 fold reduced in TNBCs as compared to normal tissues (P=0.031). In addition, miR-200c expression was 5.75 fold reduced in BRCA mutation positive TNBC tumors (P=0.005). Analysis revealed a negative correlation between miR-200c and VEGFA expressions (r=-468). Thus, miR-200c may be involved in invasion and metastasis in TNBC cases with BRCA mutation. In this study we provide the knowledge on the first report of association between microRNA-200c and BRCA mutations in TNBC. Further studies and evaluations are required, but this miRNA may provide novel therapeutic molecular targets for TNBC treatment and new directions for the development of anticancer drugs.

  17. Assessment of seawater optical characteristics in the upper 200 m of ocean on their subsurface values

    Science.gov (United States)

    Kopelevich, Oleg V.; Prokhorenko, Olga V.

    1994-10-01

    The specific goal of this work is to develop a model and algorithms of using the optical remote sensing and/or the Secchi disk depth data for an assessment of sea water optical characteristics up to 200 m taking into account the vertical stratification. Measurement data of the scattering coefficient b(550) and of the volume scattering function at 1 degree(s), 6 degree(s), 45 degree(s) angles at 550 nm as well as of the absorption coefficient a(390), a(430) at 390 and 430 nm in the Atlantic, Pacific and Indian Oceans were grouped at five layers and were statistically analyzed. Relative standard errors of the a(390), a(430), b(550) values being calculated for deeper layers by their values at 0 - 10 m layer are estimated as 12 - 35%. A model is also developed to estimate the values of the scattering coefficient in the upper 200 m through the Secchi disk depth; the values of the volume scattering function for different layers can be assessed by using the mean scattering phase functions calculated for clear and turbid waters. The spectral absorption coefficients in the upper 200 m can be evaluated in principle by values of the diffuse coefficient KD(490) at 0 - 10 m layer.

  18. Top 200 Prescribed Drugs Mostly Prescribed by the Physician in Pharmacies at Medan City

    Science.gov (United States)

    Tanjung, H. R.; Nasution, E. S.

    2017-03-01

    The drug information literatures usually contains thousands of drugs, which much of them were rare or never prescribed by the physicians. It caused pharmacy students must learn thousands of drugs that will depleted resources and the study result was not effective. The aim of the study was to identify 200 items of drugs that mostly prescribed by the physicians in the pharmacies at Medan City. The study was a descriptive study that used a cross sectional survey methodology. The 200 items of drugs that mostly prescribed by the physician obtained from the pharmacies selected regarding to random sampling method. The study was conducted from August to September 2016. The 200 items of drugs that mostly prescribed by the physician resulted from 21.962 prescribed drugs item of 16.352 prescriptions of 100 pharmacies. The list revealed that the most prescribed drugs was amoxicilline (5.55 %), followed by dexamethasone (4.44%), mefenamic acid (3.73%), cetirizine (3.16%), and ciprofloxacine (2.97%). It shows that the antibiotic drug was the most prescribed drug by the physician in pharmacies at Medan City. Further studies are required to develop the study card from the list.

  19. Estimate of Leaf Chlorophyll and Nitrogen Content in Asian Pear (Pyrus serotina Rehd. by CCM-200

    Directory of Open Access Journals (Sweden)

    Mostafa GHASEMI

    2011-03-01

    Full Text Available In many cases evaluation of chlorophyll and nitrogen content in plants need to destructive methods, more time and organic solvents. Application of chlorophyll meters save time and resources. The aim of this study was estimating of chlorophyll and nitrogen content in Asian pear leaves using non-destructive method and rapid quantification of chlorophyll by chlorophyll content meter (CCM-200. This study was conducted on 8 years old Asian pear trees during June 2008 in Tehran, Iran. To develop our regression model, the chlorophyll meter data were correlated with extracted chlorophyll and nitrogen content data obtained from DMSO and Kejeldal methods, respectively. The results showed that, there was positive and linear correlation between CCM-200 data and chlorophyll a (R�=0.7183, chlorophyll b (R�=0.8523, total chlorophyll (R�=0.90, and total nitrogen content (R�=0.76 in Asian pear leaves. Thus, it can be concluded that, CCM-200 can be used in order to predict both chlorophyll and nitrogen content in Asian pear leaves.

  20. ALTERNATIVE REMEDIATION TECHNOLOGY STUDY FOR GROUNDWATER TREATMENT AT 200-PO-1 OPERABLE UNIT AT HANFORD SITE

    Energy Technology Data Exchange (ETDEWEB)

    DADO MA

    2008-07-31

    This study focuses on the remediation methods and technologies applicable for use at 200-PO-I Groundwater Operable Unit (OU) at the Hanford Site. The 200-PO-I Groundwater au requires groundwater remediation because of the existence of contaminants of potential concern (COPC). A screening was conducted on alternative technologies and methods of remediation to determine which show the most potential for remediation of groundwater contaminants. The possible technologies were screened to determine which would be suggested for further study and which were not applicable for groundwater remediation. COPCs determined by the Hanford Site groundwater monitoring were grouped into categories based on properties linking them by remediation methods applicable to each COPC group. The screening considered the following criteria. (1) Determine if the suggested method or technology can be used for the specific contaminants found in groundwater and if the technology can be applied at the 200-PO-I Groundwater au, based on physical characteristics such as geology and depth to groundwater. (2) Evaluate screened technologies based on testing and development stages, effectiveness, implementability, cost, and time. This report documents the results of an intern research project conducted by Mathew Dado for Central Plateau Remediation in the Soil and Groundwater Remediation Project. The study was conducted under the technical supervision of Gloria Cummins and management supervision of Theresa Bergman and Becky Austin.