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Sample records for astatine 200

  1. Organic chemistry of astatine

    International Nuclear Information System (INIS)

    The paper surveys the investigations on the chemical behaviour of astatine in organic systems and deals with the preparation and identification of its organic compounds. A discussion is given on some of the physico-chemical properties of these compounds determined by extrapolation techniques as well as by direct measurement. The biomedical importance of 211At-labelled compounds is briefly referred to. (authors)

  2. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  3. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. Dosimetrical considerations in astatine-211 radioimmunotherapy

    International Nuclear Information System (INIS)

    Several dosimetrical quantities have been suggested for use in alpha-particle dosimetry. To evaluate the expected biological effect when using these quantities, a Monte Carlo program was set to register the single-event distribution of both specific energy and alpha-particle track length to a cell nucleus (r=5.6 μm). Distributions were acquired for both 'bound' (simulating the effect of 211At-labelled antibodies bound to antigens on cell surfaces (r=7.0 μm)) as well as 'non-bound' (simulating 211At-labelled antibodies that have not bound to a cell) astatine-211. From these distributions, various theoretical cell survival curves were established for 3 different dosimetrical quantities, i.e. specific energy, number of alpha-particle hits and total track length. The survival curves for all quantities are presented for the corresponding mean absorbed dose in order to facilitate comparisons of the expected effects of using the 3 different quantities for both distributions of 211At decays. The theoretical survival curves presented here could, combined with experiments using 'bound' and 'non-bound' 211At in a single-cell suspension, reveal which dosimetrical quantity is most suitable for 211 At-radioimmunotherapy. (author)

  6. Discovery of the astatine, radon, francium, and radium isotopes

    OpenAIRE

    Fry, C; Thoennessen, M

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  7. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  8. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  9. Scrutinizing "Invisible" astatine: A challenge for modern density functionals.

    Science.gov (United States)

    Sergentu, Dumitru-Claudiu; David, Grégoire; Montavon, Gilles; Maurice, Rémi; Galland, Nicolas

    2016-06-01

    The main-group 6p elements did not receive much attention in the development of recent density functionals. In many cases it is still difficult to choose among the modern ones a relevant functional for various applications. Here, we illustrate the case of astatine species (At, Z = 85) and we report the first, and quite complete, benchmark study on several properties concerning such species. Insights on geometries, transition energies and thermodynamic properties of a set of 19 astatine species, for which reference experimental or theoretical data has been reported, are obtained with relativistic (two-component) density functional theory calculations. An extensive set of widely used functionals is employed. The hybrid meta-generalized gradient approximation (meta-GGA) PW6B95 functional is overall the best choice. It is worth noting that the range-separated HSE06 functional as well as the old and very popular B3LYP and PBE0 hybrid-GGAs appear to perform quite well too. Moreover, we found that astatine chemistry in solution can accurately be predicted using implicit solvent models, provided that specific parameters are used to build At cavities. © 2016 Wiley Periodicals, Inc. PMID:27059181

  10. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  11. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  12. Astatine-211: production, injection into monoclonal antibodies radiological effect, possible application to cancer treatment

    International Nuclear Information System (INIS)

    Methods developed in the Laboratory of Nuclear Problems, JINR, for producing astatine-211 and injecting it into monoclonal antibodies are described. The use of its diethylene triamine penta-acetic acid complex is shown to be the most effective method of injecting astatine into a biomolecules. The biological effect of the α-particles emitted from the astatine-211 is investigated using Chinese hamster fibroblasts and Ehrlich carcinoma cells. It is established that the mitotic activity depression, number of degenerating cells, number of cells with chromosome aberrations, and cellular surviving fraction depend on the concentration of the radionuclide in the medium 'in vitro'. The RBE of α-particles in comparison with 60Co γ-rays is 3. Injection of astatine-211 absorbed on tellurium particles into mice with ascitic tumors resulted in prolongation of their life or elimination of the tumors. (author). 39 refs, 7 figs

  13. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  14. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    Science.gov (United States)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-07-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method that combines dry distillation of astatine-211 and a synthesis module for producing radiopharmaceuticals into a process platform. This platform will standardize production of astatinated radiopharmaceuticals, and hence, it will facilitate large clinical studies focused on this promising, but chemically challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies.

  15. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-01-01

    vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method......To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and...... challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies....

  16. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  17. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  18. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  19. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  20. Direct astatination of a tumour-binding protein, human epidermal growth factor, using nido-carborane as a prosthetic group

    International Nuclear Information System (INIS)

    A method for direct astatine labeling of proteins has been investigated. Binding sites for astatine were created by coupling of a nido-carborane derivative to a protein, the human epidermal growth factor (hEGF), using two different conjugation methods - by glutaraldehyde cross-linking or by introduction of sulfohydryl groups by Traut's reagent with subsequent linking of ANC-1 with m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester. The conjugates were astatinated using the Chloramine-T method in high yield. The best labeling was obtained by the glutaraldehyde conjugate with an average yield of 68 ± 9%. In vitro stability tests indicated that the glutaraldehyde conjugated label was as stable as hEGF labeled with astatobenzoate. (author)

  1. Labelling prospects of astatine-211 with immunoglobulins (IgG): some general considerations

    International Nuclear Information System (INIS)

    The tumour therapeutic potential of the short lived alpha emitting radiohalogen 211At has been already been well recognised in the field of radioimmuno therapy. There is no evidence as such to show that astatine itself is a tumour seeking isotope. Therefore it has to be tagged to tumour seeking compound such as a drug or a protein preferably an antibody (IgG). In this communication, the labelling parameters which are required to be investigated for obtaining a stable product which could be useful as radioimmuno therapeutic agent, are described. (author). 6 refs

  2. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  3. Extraction of 211At-astatine from hydrochloric acid solutions by means of TOPO, TBP, and triphenylphosphine

    International Nuclear Information System (INIS)

    The extraction behaviour of astatine was studied under defined conditions from hydrochloride acid solutions (cHCl>0.1 M or 1 and 2M). Therefore other effects like adsorption, reduction or hydrolysis can be excluded. The present work describes the extraction with tri- n- octylphosphinoxide (TOPO), tri- n-butylphosphate (TBP) and tri-phenylphosphine in chloroform. (orig.)

  4. No-carrier-added astatination of N-succinimidyl-3-(tri-n-butylstannyl) benzoate (ATE) via electrophilic destannylation

    International Nuclear Information System (INIS)

    The no-carrier-added synthesis of N-succinimidyl 3-[211At]astato-benzoate from N-succinimidyl 3-(tri-n-butylstannyl)benzoate (ATE) is described. The nature of the solvent in which the 211At was isolated from the target was an important factor influencing both the radiochemical yields and the nature of the incorporated astatine activity. (orig.)

  5. 211At-Rh(16-S4-diol) complex as a precursor for astatine radiopharmaceuticals

    International Nuclear Information System (INIS)

    211At is one of the most promising radionuclides in α-radioimmunotherapy (α-RIT). Unfortunately, biomolecules labeled by direct electrophilic astatination are unstable due to the rapid loss of 211At under both in vitro and in vivo conditions. The present paper describes the results of our studies on attaching At- to the rhodium(III) complex with thioether ligand: 1,5,9,13-etrathiacyclohexadecane-3,11-diol (16-S4-diol). Rh3+ was chosen as a moderately soft metal cation which should form very strong bonds with soft At- anions, but first of all because of the kinetic inertness of low spin rhodium(III) d6 complexes. The 16-S4-diol ligand was selected due to formation of stable complexes with Rh3+. The experiments related to optimization of the reaction conditions were performed with the 131I, basing on a chemical similarity of I- to At-. The experiments with 211At were then carried out under the conditions found optimal for I-. The preliminary results are promising, and indicate a possibility for astatination of biomolecules by using the 211At-Rh(16-S4-diol) complex

  6. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  7. HTT 200 Course/HTT200nerddotcom

    OpenAIRE

    Entirecourse,dqs,checkpoints

    2015-01-01

    For More Course Tutorials Visit www.htt200nerd.com   HTT 200 Final Project: Foreign Destination Research Project HTT 200 Week 1 CheckPoint: Job Opportunities HTT 200 Week 2 Assignment: Demographics HTT 200 Week 2 CheckPoint: Diversity HTT 200 Week 3 CheckPoint: Casual Restaurants HTT 200 Week 4 Assignment: Franchising HTT 200 Week 4 CheckPoint: Chain and Independent Restaurants HTT 200 Week 5 CheckPoint: Customer Types HTT 200 Week 6 Assignment...

  8. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  9. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  10. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  11. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  12. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  13. HTT200 phoenix Material-htt200dotcom

    OpenAIRE

    sandy

    2015-01-01

    HTT 200 Entire Course (UOP) For more course tutorials visit www.htt200.com   HTT 200 Final Project: Foreign Destination Research Project HTT 200 Week 1 CheckPoint: Job Opportunities HTT 200 Week 2 Assignment: Demographics HTT 200 Week 2 CheckPoint: Diversity HTT 200 Week 3 CheckPoint: Casual Restaurants HTT 200 Week 4 Assignment: Franchising HTT 200 Week 4 CheckPoint: Chain and Independent Restaurants HTT 200 Week 5 CheckPoint: Customer Types ...

  14. Stability and in vivo behavior of Rh[16aneS4-diol]211At complex: A potential precursor for astatine radiopharmaceuticals

    International Nuclear Information System (INIS)

    Introduction: The heavy halogen 211At is of great interest for targeted radiotherapy because it decays by the emission of short-range, high-energy α-particles. However, many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking other 211At labeling strategies. One relatively unexplored approach is to utilize prosthetic groups based on astatinated rhodium (III) complex stabilized with a tetrathioether macrocyclic ligand – Rh[16aneS4-diol]211At. The purpose of the current study was to evaluate the in vitro and in vivo stability of this complex in comparison to its iodine analog – Rh[16aneS4-diol]131I. Methods: Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I complexes were synthesized and purified by HPLC. The stability of both complexes was evaluated in vitro by incubation in phosphate-buffered saline (PBS) and human serum at different temperatures. The in vivo behavior of the two radiohalogenated complexes was assessed by a paired-label biodistribution study in normal Balb/c mice. Results: Both complexes were synthesized in high yield and purity. Almost no degradation was observed for Rh[16aneS4-diol]131I in PBS over a 72 h incubation. The astatinated analog exhibited good stability in PBS over 14 h. A slow decline in the percentage of intact complex was observed for both tracers in human serum. In the biodistribution study, retention of 211At in most tissues was higher than that of 131I at all time points, especially in spleen and lungs. Renal clearance of Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I predominated, with 84.1 ± 2.3% and 94.6 ± 0.9% of injected dose excreted via the urine at 4 h. Conclusions: The Rh[16aneS4-diol]211At complex might be useful for constructing prosthetic groups for the astatination of biomolecules and further studies are planned to evaluate this possibility

  15. FIN 200 UOP Course Tutorial / fin200dotcom

    OpenAIRE

    anil14

    2015-01-01

    FIN 200 Entire Course For more course tutorials visit   www.fin200.com   FIN 200 Week 1 CheckPoint Financial Management Goals FIN 200 Week 1 Assignment Cash Flow Preparation FIN 200 Week 2 Checkpoint Financial Ratios FIN 200 Week 2 DQ 1 & DQ 2 FIN 200 Week 3 CheckPoint Financial Forecasting FIN 200 Week 3 Assignment Pro Forma Statements FIN 200 Week 4 Checkpoint Break Even Analysis FIN 200 Week 4 DQ 1 & DQ 2 FIN 200 Week 5 CheckPo...

  16. FIN 200 Uop Material-fin200dotcom

    OpenAIRE

    Sandywilliam6

    2015-01-01

    FIN 200 Entire Course For more course tutorials visit   www.fin200.com   FIN 200 Week 1 CheckPoint Financial Management Goals FIN 200 Week 1 Assignment Cash Flow Preparation FIN 200 Week 2 Checkpoint Financial Ratios FIN 200 Week 2 DQ 1 & DQ 2 FIN 200 Week 3 CheckPoint Financial Forecasting FIN 200 Week 3 Assignment Pro Forma Statements FIN 200 Week 4 Checkpoint Break Even Analysis FIN 200 Week 4 DQ 1 & DQ 2 FIN 200 Week 5 CheckPo...

  17. Status of EXO-200

    OpenAIRE

    Ackerman, Nicole

    2009-01-01

    EXO-200 is the first phase of the Enriched Xenon Observatory (EXO) experiment, which searches for neutrinoless double beta decay in 136Xe to measure the mass and probe the Majorana nature of the neutrino. EXO-200 consists of 200 kg of liquid Xe enriched to 80% in 136Xe in an ultra-low background TPC. Energy resolution is enhanced through the simultaneous collection of scintillation light using Large Area Avalanche Photodiodes (LAAPD's) and ionization charge. It is being installed at the WIPP ...

  18. AED 200 Courses Tutorial / indigohelp

    OpenAIRE

    nesa

    2015-01-01

    AED 200 Week 1 DQ1 and DQ2 AED 200 Week 1 CheckPoint Teacher Certification Licensure AED 200 Week 2 CheckPoint Students Social Challenges AED 200 Week 2 CheckPoint Social Justice AED 200 Week 2 Assignment Multicultural Education Scenario AED 200 Week 3 DQ 1 and DQ 2 AED 200 Week 3 CheckPoint School Funding Issues AED 200 Week 4 CheckPoint Religion in Schools AED 200 Week 4 CheckPoint Debate Project Outline AED 200 Week 4 Assignment Students Rights and Teach...

  19. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  20. Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter

    International Nuclear Information System (INIS)

    The sodium/iodide symporter (NIS) has been recognized as an attractive target for radioiodine-mediated cancer gene therapy. In this study we investigated the role of human NIS for cellular uptake of the high LET α-emitter astatine-211 (211At) in comparison with radioiodine as a potential radionuclide for future applications. A mammalian NIS expression vector was constructed and used to generate six stable NIS-expressing cancer cell lines (three derived from thyroid carcinoma, two from colon carcinoma, one from glioblastoma). Compared with the respective control cell lines, steady state radionuclide uptake of NIS-expressing cell lines increased up to 350-fold for iodine-123 (123I), 340-fold for technetium-99m pertechnetate (99mTcO4-) and 60-fold for 211At. Cellular 211At accumulation was found to be dependent on extracellular Na+ ions and displayed a similar sensitivity towards sodium perchlorate inhibition as radioiodide and 99mTcO4- uptake. Heterologous competition with unlabelled NaI decreased NIS-mediated 211At uptake to levels of NIS-negative control cells. Following uptake both radioiodide and 211At were rapidly (apparent t1/2 3-15 min) released by the cells as determined by wash-out experiments. Data of scintigraphic tumour imaging in a xenograft nude mice model of transplanted NIS-modified thyroid cells indicated that radionuclide uptake in NIS-expressing tumours was up to 70 times (123I), 25 times (99mTcO4-) and 10 times (211At) higher than in control tumours or normal tissues except stomach (3-5 times) and thyroid gland (5-10 times). Thirty-four percent and 14% of the administered activity of 123I and 211At, respectively, was found in NIS tumours by region of interest analysis (n=2). Compared with cell culture experiments, the effective half-life in vivo was greatly prolonged (6.5 h for 123I, 5.2 h for 211At) and preliminary dosimetric calculations indicate high tumour absorbed doses (3.5 Gy/MBqtumour for 131I and 50.3 Gy/MBqtumour for 211At). In

  1. Status of EXO-200

    CERN Document Server

    Ackerman, Nicole

    2009-01-01

    EXO-200 is the first phase of the Enriched Xenon Observatory (EXO) experiment, which searches for neutrinoless double beta decay in 136Xe to measure the mass and probe the Majorana nature of the neutrino. EXO-200 consists of 200 kg of liquid Xe enriched to 80% in 136Xe in an ultra-low background TPC. Energy resolution is enhanced through the simultaneous collection of scintillation light using Large Area Avalanche Photodiodes (LAAPD's) and ionization charge. It is being installed at the WIPP site in New Mexico, which provides a 2000 meter water-equivalent overburden. EXO-200 will begin taking data in 2009, with the expected two-year sensitivity to the half-life for neutrinoless double beta decay of 6.4 10^25 years. According to the most recent nuclear matrix element calculations, this corresponds to an effective Majorana neutrino mass of 0.13 to 0.19 eV. It will also measure the two neutrino mode for the first time in 136Xe.

  2. Status of EXO-200

    Energy Technology Data Exchange (ETDEWEB)

    Ackerman, Nicole; /SLAC

    2011-12-06

    EXO-200 is the first phase of the Enriched Xenon Observatory (EXO) experiment, which searches for neutrinoless double beta decay in {sup 136}Xe to measure the mass and probe the Majorana nature of the neutrino. EXO-200 consists of 200 kg of liquid Xe enriched to 80% in {sup 136}Xe in an ultra-low background TPC. Energy resolution is enhanced through the simultaneous collection of scintillation light using Large Area Avalanche Photodiodes (LAAPD's) and ionization charge. It is being installed at the WIPP site in New Mexico, which provides a 2000 meter water-equivalent overburden. EXO-200 will begin taking data in 2009, with the expected two-year sensitivity to the half-life for neutrinoless double beta decay of 6.4 x 10{sup 25} years. According to the most recent nuclear matrix element calculations, this corresponds to an effective Majorana neutrino mass of 0.13 to 0.19 eV. It will also measure the two neutrino mode for the first time in {sup 136}Xe.

  3. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  4. Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter

    Energy Technology Data Exchange (ETDEWEB)

    Petrich, T.; Helmeke, H.-J.; Meyer, G.J.; Knapp, W.H.; Poetter, E. [Department of Nuclear Medicine, Medizinische Hochschule Hannover (Germany)

    2002-07-01

    The sodium/iodide symporter (NIS) has been recognized as an attractive target for radioiodine-mediated cancer gene therapy. In this study we investigated the role of human NIS for cellular uptake of the high LET {alpha}-emitter astatine-211 ({sup 211}At) in comparison with radioiodine as a potential radionuclide for future applications. A mammalian NIS expression vector was constructed and used to generate six stable NIS-expressing cancer cell lines (three derived from thyroid carcinoma, two from colon carcinoma, one from glioblastoma). Compared with the respective control cell lines, steady state radionuclide uptake of NIS-expressing cell lines increased up to 350-fold for iodine-123 ({sup 123}I), 340-fold for technetium-99m pertechnetate ({sup 99m}TcO{sub 4}{sup -}) and 60-fold for {sup 211}At. Cellular {sup 211}At accumulation was found to be dependent on extracellular Na{sup +} ions and displayed a similar sensitivity towards sodium perchlorate inhibition as radioiodide and {sup 99m}TcO{sub 4}{sup -} uptake. Heterologous competition with unlabelled NaI decreased NIS-mediated {sup 211}At uptake to levels of NIS-negative control cells. Following uptake both radioiodide and {sup 211}At were rapidly (apparent t{sub 1/2} 3-15 min) released by the cells as determined by wash-out experiments. Data of scintigraphic tumour imaging in a xenograft nude mice model of transplanted NIS-modified thyroid cells indicated that radionuclide uptake in NIS-expressing tumours was up to 70 times ({sup 123}I), 25 times ({sup 99m}TcO{sub 4}{sup -}) and 10 times ({sup 211}At) higher than in control tumours or normal tissues except stomach (3-5 times) and thyroid gland (5-10 times). Thirty-four percent and 14% of the administered activity of {sup 123}I and {sup 211}At, respectively, was found in NIS tumours by region of interest analysis (n=2). Compared with cell culture experiments, the effective half-life in vivo was greatly prolonged (6.5 h for {sup 123}I, 5.2 h for {sup 211}At) and

  5. Comment: 200 [Taxonomy Icon

    Lifescience Database Archive (English)

    Full Text Available 合データベースセンター) Photo: Takeru Nakazato (Database Center for Life Science) nakazato 2009/11/04 17:26:47 2010/01/14 20:11:35 ... ...Japanese tree frog Hyla japonica Hyla_japonica_L.png 200.png Takeru Nakazato (Database Center for Life Scien...ce) licensed under CC Attribution2.1 Japan ニホンアマガエル Hyla japonica 撮影:仲里猛留(ライフサイエンス統

  6. Physics at LEP 200

    International Nuclear Information System (INIS)

    The LEP project has always been understood as an e+e- collider with an energy of 100 GeV per beam. In 1981 it was decided to introduce a step in energy and to make available as soon as possible 50 GeV per beam, the so called LEP I phase. A tremendous effort is underway to construct both the machine and the detectors, most of this concentrated on the start of physics with LEP I. Nevertheless a workshop was proposed to study the experimental and theoretical aspects of the physics feasible at LEP 200. It was organized by ECFA under the chairmanship of W. Hoogland and held at Aachen in September 29th 1986. Many contributions were presented and the summary was given by Professor D. Perkins. A few weeks ago the proceedings appeared. I have used essentially all the various results of the working groups of the workshop and I will refer to the proceedings as the Green Book. Many discussions and results were already mentionned in Physics at LEP referred to as the Yellow Book. An excellent lecture given by R.P. PECCEI at the CERN School has also been very useful to me. In this report I would like to discuss the following points: upgrading of the machine to 200 GeV. Physics to the W's. Higgs boson search. Toponium physics. Non-standard physics, and finally give a conclusion

  7. Rabbit CD200R binds host CD200 but not CD200-like proteins from poxviruses

    Science.gov (United States)

    Akkaya, Munir; Kwong, Lai-Shan; Akkaya, Erdem; Hatherley, Deborah; Barclay, A. Neil

    2016-01-01

    CD200 is a widely distributed membrane protein that gives inhibitory signals through its receptor (CD200R) on myeloid cells. CD200 has been acquired by herpesviruses where it has been shown to interact with host CD200R and downmodulate the immune system. It has been hypothesized that poxviruses have acquired CD200; but the potential orthologues show less similarity to their hosts. Myxoma virus M141 protein is a potential CD200 orthologue with a potent immune modulatory function in rabbits. Here, we characterized the rabbit CD200, CD200R and tested the CD200-like sequences for binding CD200R. No binding could be detected using soluble recombinant proteins, full length protein expressed on cells or myxoma virus infected cells. Finally, using knockdown models, we showed that the inhibitory effect of M141 on RAW 264.7 cells upon myxoma virus infection is not due to CD200R. We conclude that the rabbit poxvirus CD200-like proteins cause immunomodulation without utilizing CD200R. PMID:26590792

  8. HTT 200 UOP Coureses/UOP Help

    OpenAIRE

    royal12

    2015-01-01

     HTT 200 Entire Course For more course tutorials visit www.uophelp.com HTT 200 Final Project: Foreign Destination Research Project HTT 200 Week 1 CheckPoint: Job Opportunities HTT 200 Week 2 Assignment: Demographics HTT 200 Week 2 CheckPoint: Diversity HTT 200 Week 3 CheckPoint: Casual Restaurants HTT 200 Week 4 Assignment: Franchising HTT 200 Week 4 CheckPoint: Chain and Independent Restaurants HTT 200 Week 5 CheckPoint: Customer Types HTT 200...

  9. Hanford 200 Areas Development Plan

    International Nuclear Information System (INIS)

    The purpose of the Hanford 200 Areas Development Plan (Development Plan) is to guide the physical development of the 200 Areas (which refers to the 200 East Area, 200 West Area, and 200 Area Corridor, located between the 200 East and 200 West Areas) in accordance with US Department of Energy (DOE) Order 4320.lB (DOE 1991a) by performing the following: Establishing a land-use plan and setting land-use categories that meet the needs of existing and proposed activities. Coordinating existing, 5-year, and long-range development plans and guiding growth in accordance with those plans. Establishing development guidelines to encourage cost-effective development and minimize conflicts between adjacent activities. Identifying site development issues that need further analysis. Integrating program plans with development plans to ensure a logical progression of development. Coordinate DOE plans with other agencies [(i.e., Washington State Department of Ecology (Ecology) and US Environmental Protection Agency (EPA)]. Being a support document to the Hanford Site Development Plan (DOE-RL 1990a) (parent document) and providing technical site information relative to the 200 Areas

  10. Hanford 200 Areas Development Plan

    Energy Technology Data Exchange (ETDEWEB)

    Rinne, C.A.; Daly, K.S.

    1993-08-01

    The purpose of the Hanford 200 Areas Development Plan (Development Plan) is to guide the physical development of the 200 Areas (which refers to the 200 East Area, 200 West Area, and 200 Area Corridor, located between the 200 East and 200 West Areas) in accordance with US Department of Energy (DOE) Order 4320.lB (DOE 1991a) by performing the following: Establishing a land-use plan and setting land-use categories that meet the needs of existing and proposed activities. Coordinating existing, 5-year, and long-range development plans and guiding growth in accordance with those plans. Establishing development guidelines to encourage cost-effective development and minimize conflicts between adjacent activities. Identifying site development issues that need further analysis. Integrating program plans with development plans to ensure a logical progression of development. Coordinate DOE plans with other agencies [(i.e., Washington State Department of Ecology (Ecology) and US Environmental Protection Agency (EPA)]. Being a support document to the Hanford Site Development Plan (DOE-RL 1990a) (parent document) and providing technical site information relative to the 200 Areas.

  11. HTT 200 UOP Course Tutorial / Tutoriloutlet

    OpenAIRE

    JANU

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com     HTT 200 Final Project: Foreign Destination Research Project HTT 200 Week 1 CheckPoint: Job Opportunities HTT 200 Week 2 Assignment: Demographics HTT 200 Week 2 CheckPoint: Diversity HTT 200 Week 3 CheckPoint: Casual Restaurants HTT 200 Week 4 Assignment: Franchising HTT 200 Week 4 CheckPoint: Chain and Independent Restaurants HTT 200 Week 5 CheckPoint: Customer Types HTT 200 We...

  12. Catch tanks inhibitor addition 200-East and 200-West Areas

    International Nuclear Information System (INIS)

    Reported is the study of 11 catch tanks in the 200-East Area and the 7 catch tanks in the 200-West Area listed as active. The location, capacity, material of construction, annual total accumulation, annual rain intrusion, waste transfer rate, and access for chemical injection in these tanks are documented. The present and future utilization and isolation plans for the catch tanks are established

  13. Durable donor engraftment after radioimmunotherapy using α-emitter astatine-211-labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation.

    Science.gov (United States)

    Chen, Yun; Kornblit, Brian; Hamlin, Donald K; Sale, George E; Santos, Erlinda B; Wilbur, D Scott; Storer, Barry E; Storb, Rainer; Sandmaier, Brenda M

    2012-02-01

    To reduce toxicity associated with external γ-beam radiation, we investigated radioimmunotherapy with an anti-CD45 mAb labeled with the α-emitter, astatine-211 ((211)At), as a conditioning regimen in dog leukocyte antigen-identical hematopoietic cell transplantation (HCT). Dose-finding studies in 6 dogs treated with 100 to 618 μCi/kg (211)At-labeled anti-CD45 mAb (0.5 mg/kg) without HCT rescue demonstrated dose-dependent myelosuppression with subsequent autologous recovery, and transient liver toxicity in dogs treated with (211)At doses less than or equal to 405 μCi/kg. Higher doses of (211)At induced clinical liver failure. Subsequently, 8 dogs were conditioned with 155 to 625 μCi/kg (211)At-labeled anti-CD45 mAb (0.5 mg/kg) before HCT with dog leukocyte antigen-identical bone marrow followed by a short course of cyclosporine and mycophenolate mofetil immunosuppression. Neutropenia (1-146 cells/μL), lymphopenia (0-270 cells/μL), and thrombocytopenia (1500-6560 platelets/μL) with prompt recovery was observed. Seven dogs had long-term donor mononuclear cell chimerism (19%-58%), whereas 1 dog treated with the lowest (211)At dose (155 μCi/kg) had low donor mononuclear cell chimerism (5%). At the end of follow-up (18-53 weeks), only transient liver toxicity and no renal toxicity had been observed. In conclusion, conditioning with (211)At-labeled anti-CD45 mAb is safe and efficacious and provides a platform for future clinical trials of nonmyeloablative transplantation with radioimmunotherapy-based conditioning. PMID:22134165

  14. Safety analyses for NHR-200

    International Nuclear Information System (INIS)

    The NHR-200 is a commercial 200-MW District Heating Reactor developed in China. It is designed on the basis of design, construction and four-year operating experience of the 5MW Experimental Heating Reactor (NHR-5). It has special safety features which are briefly described in this paper. Accident classification and safety criteria are also explained. Some typical and serious accidents are studied theoretically, and their results are detailed in this paper. They demonstrate the excellent safety characteristics of HR-200. (author). 4 refs, 9 figs, 1 tab

  15. FIN 200 (UOP) course tutorial/tutorialoutlet

    OpenAIRE

    naresh 1

    2015-01-01

    For more course tutorials visit www.tutorialoutlet.com     FIN 200 Week 1 CheckPoint Financial Management Goals (UOP) FIN 200 Week 1 Assignment Cash Flow Preparation (UOP) FIN 200 Week 2 Checkpoint Financial Ratios (UOP) FIN 200 Week 2 DQ 1 & DQ 2 (UOP) FIN 200 Week 3 CheckPoint Financial Forecasting (UOP) FIN 200 Week 3 Assignment Pro Forma Statements (UOP) FIN 200 Week 4 Checkpoint Break Even Analysis (UOP) FIN 200 Week 4 DQ 1 & ...

  16. CJS 200 UOP Course Tutorial/ Tutorialrank

    OpenAIRE

    SICENK

    2015-01-01

    For more course tutorials visit www.tutorialrank.com Tutorial Purchased: 3 Times, Rating: A+   CJS 200 Assignment: The Prison System CJS 200 Assignment: The Effects of Punishment and Sentencing CJS 200 CheckPoint: Prison Populations CJS 200 Assignment: Inside Criminal Law CJS 200 CheckPoint: Causation of Crime CJS 200 CheckPoint: Law Enforcement Agencies CJS 200 Assignment: The Rules of Law Enforcement CJS 200 CheckPoint: Terrorism and Cyber Cr...

  17. 200 GW for Germany; 200 Gigawatt fuer Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Fuhs, Michael; Enkhardt, Sandra

    2012-11-01

    200 GW of solar power, i.e. seven times as much as today: Is that a realistic goal, or is it just propaganda for a lobby intending to make a good life for manufacturers and fitters? There is much to suggest that it may be a socially relevant goal.

  18. FIN 200 UOP COURSE Tutorial/UOPHELP

    OpenAIRE

    sdfghj

    2015-01-01

    For more course tutorials visit www.uophelp.com   FIN 200 Week 1 CheckPoint Financial Management Goals FIN 200 Week 1 Assignment Cash Flow Preparation FIN 200 Week 2 Checkpoint Financial Ratios FIN 200 Week 2 DQ 1 & DQ 2 FIN 200 Week 3 CheckPoint Financial Forecasting FIN 200 Week 3 Assignment Pro Forma Statements FIN 200 Week 4 Checkpoint Break Even Analysis FIN 200 Week 4 DQ 1 & DQ 2 FIN 200 Week 5 CheckPoint Long-Term and Short-Term Financin...

  19. AED 200 UOP course/uophelp

    OpenAIRE

    uophelp

    2015-01-01

    For more course tutorials visit www.uophelp.com   AED 200 Week 1 DQ1 and DQ2 AED 200 Week 1 CheckPoint Teacher Certification Licensure AED 200 Week 2 CheckPoint Students Social Challenges AED 200 Week 2 CheckPoint Social Justice AED 200 Week 2 Assignment Multicultural Education Scenario AED 200 Week 3 DQ 1 and DQ 2 AED 200 Week 3 CheckPoint School Funding Issues AED 200 Week 4 CheckPoint Religion in Schools AED 200 Week 4 CheckPoint Debate Proj...

  20. 150V/200V MOSFET

    Institute of Scientific and Technical Information of China (English)

    刘广荣

    2009-01-01

    据《世界电子元器件》2009年9月月刊报道,IR推出一系列150 V和200 VHEXFET功率MOSFET,为开关模式电源(SMPS)、不断电系统(UPS)、反相器和DC马达驱动器等工业应用提供极低的闸电荷(Qg)。随着DC/DC功率转换应用技术的日益进步,开关频率也有所提高,输入电

  1. Fission hindrance studies in 200Pb

    International Nuclear Information System (INIS)

    In the present investigation evaporation residues (ERs) and spin distribution (gamma fold) for the 200Pb have been measured with different entrance channel (16O +184W → 200Pb) at beam energies 84 to 120 MeV

  2. 20 CFR 416.200 - Introduction.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Introduction. 416.200 Section 416.200 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility General § 416.200 Introduction. You are eligible for SSI benefits if you meet all...

  3. 4 CFR 200.7 - Fees.

    Science.gov (United States)

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Fees. 200.7 Section 200.7 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PRIVACY ACT OF 1974 § 200.7 Fees. A fee will not be charged for searching, reviewing, or making corrections to records. A fee for copying will be assessed at the same rate...

  4. 17 CFR 200.310 - Fees.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Fees. 200.310 Section 200.310... Maintained by the Commission § 200.310 Fees. (a) A request by an individual for copies of a record pertaining... the copier and the Commission. (b) Waiver or reduction of fees. Whenever the Privacy Act...

  5. 17 CFR 200.552 - NEPA planning.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false NEPA planning. 200.552 Section 200.552 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT... § 200.552 NEPA planning. Where it is reasonably foreseeable by the Commission that it may be required...

  6. 29 CFR 99.200 - Audit requirements.

    Science.gov (United States)

    2010-07-01

    ... financial statement audit of the auditee, the auditee may elect to have a program-specific audit conducted... 29 Labor 1 2010-07-01 2010-07-01 true Audit requirements. 99.200 Section 99.200 Labor Office of....200 Audit requirements. (a) Audit required. Non-Federal entities that expend $300,000 or more in...

  7. 40 CFR 240.200-1 - Requirement.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirement. 240.200-1 Section 240.200-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.200-1...

  8. 21 CFR 1271.200 - Equipment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Equipment. 1271.200 Section 1271.200 Food and... CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.200 Equipment. (a) General. To prevent the introduction, transmission, or spread of communicable diseases, equipment used in...

  9. 17 CFR 200.502 - Definition.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Definition. 200.502 Section 200.502 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT... Information and Material § 200.502 Definition. As used in this part: Foreign government information...

  10. 17 CFR 200.401 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Definitions. 200.401 Section 200.401 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Regulations Pertaining to Public Observation of Commission Meetings § 200.401 Definitions. As used in...

  11. 34 CFR 200.42 - Corrective action.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Corrective action. 200.42 Section 200.42 Education... Programs Operated by Local Educational Agencies Lea and School Improvement § 200.42 Corrective action. (a) Definition. “Corrective action” means action by an LEA that— (1) Substantially and directly responds to—...

  12. 36 CFR 200.2 - Field organization.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Field organization. 200.2 Section 200.2 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND PROCEDURES Organization § 200.2 Field organization. The field organization of the...

  13. 17 CFR 200.55 - Statutory obligations.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Statutory obligations. 200.55 Section 200.55 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.55 Statutory obligations. In administering the law, members of this...

  14. 49 CFR 179.200-10 - Welding.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Welding. 179.200-10 Section 179.200-10... Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-10 Welding. (a) All joints... W (IBR, see § 171.7 of this subchapter). Welding procedures, welders and fabricators shall...

  15. 34 CFR 200.15 - Timeline.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Timeline. 200.15 Section 200.15 Education Regulations... Programs Operated by Local Educational Agencies Adequate Yearly Progress (ayp) § 200.15 Timeline. (a) Each State must establish a timeline for making AYP that ensures that, not later than the 2013-2014...

  16. Treatment of cultured glioma cells with the EGFR-TKI gefitinib (''Iressa'', ZD1839) increases the uptake of astatinated EGF despite the absence of gefitinib-mediated growth inhibition

    International Nuclear Information System (INIS)

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib (''Iressa'', ZD1839), a reversible growth inhibitor of EGFR-expressing tumour cells, has been shown to enhance the antitumour effect of ionising radiation, and also to increase the uptake of radioiodinated EGF. Thus, combination of gefitinib treatment and radionuclide targeting is an interesting option for therapy of brain tumours that are difficult to treat with conventional methods. The aim of this study was to evaluate how pre-treatment with gefitinib affects binding of astatinated EGF (211At-EGF) to cultured glioma U343 cells, which express high levels of EGFR. The growth of U343 cells in the presence of gefitinib was investigated, and it was found that gefitinib does not significantly inhibit the growth of these cells. Nevertheless, the uptake of 211At-EGF in U343 cells was markedly increased (up to 3.5 times) in cells pre-treated with gefitinib (1 μM). This indicates that a combination of gefitinib treatment and radionuclide targeting to EGFR might be a useful therapeutic modality, even for patients who do not respond to treatment with gefitinib alone. (orig.)

  17. 17 CFR 200.64 - Judicial review.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Judicial review. 200.64... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.64 Judicial review. The Congress has provided for review by the courts of the decisions and orders by this Commission. Members should...

  18. 34 CFR 200.43 - Restructuring.

    Science.gov (United States)

    2010-07-01

    ...— (1) Makes fundamental reforms to improve student academic achievement in the school; (2) Has... governance, in order to improve student academic achievement in the school and that has substantial promise... 34 Education 1 2010-07-01 2010-07-01 false Restructuring. 200.43 Section 200.43...

  19. 24 CFR 200.73 - Property development.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Property development. 200.73 Section 200.73 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment,...

  20. 49 CFR 179.200-7 - Materials.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Materials. 179.200-7 Section 179.200-7 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK...

  1. 10 CFR 1021.200 - DOE planning.

    Science.gov (United States)

    2010-01-01

    ... accordance with 40 CFR 1501.2 and this section. In its planning for each proposal, DOE shall include adequate... accordance with 40 CFR 1506.3. ... 10 Energy 4 2010-01-01 2010-01-01 false DOE planning. 1021.200 Section 1021.200 Energy...

  2. 34 CFR 200.71 - LEA eligibility.

    Science.gov (United States)

    2010-07-01

    ... least five percent of the LEA's total population ages 5 to 17 years, inclusive. (d) Education finance... 34 Education 1 2010-07-01 2010-07-01 false LEA eligibility. 200.71 Section 200.71 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY...

  3. 24 CFR 200.635 - Compliance.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Compliance. 200.635 Section 200.635 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA...

  4. 24 CFR 200.600 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Purpose. 200.600 Section 200.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA...

  5. 24 CFR 960.200 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... 960, subpart E. (8) Protection for victims of domestic violence, dating violence, and stalking, 24 CFR... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Purpose. 960.200 Section 960.200 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE...

  6. 7 CFR 62.200 - Services.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Services. 62.200 Section 62.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) LIVESTOCK, MEAT, AND...

  7. 34 CFR 200.103 - Definitions.

    Science.gov (United States)

    2010-07-01

    ...; and (2) Preschool children below the age and grade level at which the agency provides free public... 34 Education 1 2010-07-01 2010-07-01 false Definitions. 200.103 Section 200.103 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY...

  8. 42 CFR 414.200 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Purpose. 414.200 Section 414.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM PAYMENT FOR PART B MEDICAL AND OTHER HEALTH SERVICES Payment for Durable Medical Equipment...

  9. 46 CFR 119.200 - General.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false General. 119.200 Section 119.200 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS MACHINERY INSTALLATION Propulsion Machinery §...

  10. 17 CFR 200.302 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Definitions. 200.302 Section 200.302 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Regulations Pertaining to the Privacy of Individuals and Systems of Records Maintained by the Commission §...

  11. 13 CFR 130.200 - Eligible entities.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Eligible entities. 130.200 Section 130.200 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS DEVELOPMENT... or university; (3) A college or school of business, engineering, commerce or agriculture; (4)...

  12. 17 CFR 200.660 - Communications.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Communications. 200.660 Section 200.660 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... Communications. (a) The agency shall take appropriate steps to ensure effective communication with...

  13. 36 CFR 200.4 - Administrative issuances.

    Science.gov (United States)

    2010-07-01

    ... Forester, a Regional Special Agent in Charge of Law Enforcement and Investigations, a Research Station... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Administrative issuances. 200.4 Section 200.4 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF...

  14. 17 CFR 200.70 - Business promotions.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Business promotions. 200.70... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.70 Business promotions. A member must not engage in any other business, employment or vocation while in office, nor may he ever use...

  15. 17 CFR 200.506 - Derivative classification.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Derivative classification. 200...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Classification and Declassification of National Security Information and Material § 200.506 Derivative classification. Any document that includes...

  16. 17 CFR 200.505 - Original classification.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Original classification. 200...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Classification and Declassification of National Security Information and Material § 200.505 Original classification. (a) No Commission Member or employee has...

  17. 7 CFR 1219.200 - Terms defined.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Terms defined. 1219.200 Section 1219.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HASS AVOCADO PROMOTION,...

  18. 7 CFR 1206.200 - Terms defined.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Terms defined. 1206.200 Section 1206.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH,...

  19. 7 CFR 1209.200 - Terms defined.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Terms defined. 1209.200 Section 1209.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MUSHROOM PROMOTION, RESEARCH,...

  20. 24 CFR 200.78 - Energy conservation.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Energy conservation. 200.78 Section... Eligibility Requirements for Existing Projects Property Requirements § 200.78 Energy conservation... conservation in accordance with standards established by the Commissioner. Mortgage Provisions...

  1. Result from, and status of, EXO-200

    Science.gov (United States)

    MacLellan, Ryan; EXO-200 Collaboration

    2016-03-01

    EXO-200 has provided one of the most sensitive searches for neutrinoless double-beta decay utilizing 175kg of enriched liquid xenon in an ultra-low background time projection chamber. This detector has demonstrated excellent energy resolution and background rejection capabilities. Using the first two years of data, EXO-200 has set a limit of 1 . 1 ×1025 y at 90% C.L. on the neutrinoless double-beta decay half-life of 136Xe. The experiment has experienced a brief hiatus in data taking during a temporary shutdown of its host facility: the Waste Isolation Pilot Plant. EXO-200 expects to resume data taking in earnest this fall with upgraded detector electronics. Results from the analysis of EXO-200 data and an update on the current status of EXO-200 will be presented.

  2. Is The CD200/CD200 Receptor Interaction More Than Just a Myeloid Cell Inhibitory Signal?

    OpenAIRE

    Minas, Konstantinos; Liversidge, Janet

    2006-01-01

    The membrane glycoprotein CD200, which has a widespread but defined distribution and a structurally similar receptor (CD200R) that transmits an inhibitory signal to cells of the hematopoetic lineage, especially myeloid cells, has been characterized. CD200R expression is restricted predominantly to cells of the myeloid lineage indicating that this ligand/receptor pair has a specific role in controlling myeloid cell function. In addition to CD200R, several related genes have been identified. Wh...

  3. 200 Irish students at CERN - virtually!

    CERN Multimedia

    2003-01-01

    On 6 October, 200 physics students from schools around Ireland paid a virtual visit to CERN and met several CERN scientists, with the help of the latest video conferencing technology using high-speed internet lines.

  4. 17 CFR 200.29 - Rules.

    Science.gov (United States)

    2010-04-01

    ... INFORMATION AND REQUESTS Organization and Program Management General Organization § 200.29 Rules. The.... Where any such proposals presents a legal problem or is a matter of first impression, or involves...

  5. 24 CFR 200.610 - Policy.

    Science.gov (United States)

    2010-04-01

    ... GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.610 Policy. It... programs shall pursue affirmative fair housing marketing policies in soliciting buyers and tenants,...

  6. 24 CFR 200.615 - Applicability.

    Science.gov (United States)

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.615 Applicability. The affirmative fair housing marketing requirements, as set forth in paragraphs (a) through...

  7. The SM-200 step motor control device

    International Nuclear Information System (INIS)

    One of the main nodes of the stand for testing and modeling solenoid coils, which define the focus of the beam of charged particles in the accelerator LUE-200 (IREN), is a device for positioning Hall sensors (HS). The mechanism of movement of the platform where HS are installed is activated by the step motor. This paper describes the control device of the step motor SM-200

  8. Brasil: 200 anos de Estado; 200 anos de administração pública; 200 anos de reformas Brazil: 200 years of state; 200 years of public administration; 200 years of reforms

    Directory of Open Access Journals (Sweden)

    Frederico Lustosa da Costa

    2008-10-01

    Full Text Available A passagem dos 200 anos da transferência da corte portuguesa para o Brasil tem suscitado a realização de inúmeros eventos comemorativos, como seminários, palestras, exposições e a publicação de livros e artigos em jornais e revistas. Entretanto, poucos encontros, discussões e publicações em torno dos "200 anos" procuraram destacar a questão da constituição do Estado nacional e da formação da administração pública brasileira. Este artigo preenche uma pequena parte da lacuna deixada na comemoração do bicentenário da chegada da família real portuguesa ao Brasil. Oferece um rápido panorama da história das transformações por que tem passado a administração pública brasileira, destacando as mudanças planejadas, quer dizer, os esforços de reforma do aparelho de Estado. São enfatizadas as três grandes reformas que se sucederam a partir de meados dos anos 1930 do século passado, separadas entre si por intervalos de 30 anos - 1937, 1967 e 1995 (ou 1998, ano da promulgação da Emenda Constitucional no 19. Todo o percurso percorrido desde 1808 configura hoje uma tríplice efeméride - 200 anos de Estado nacional, 200 anos de administração pública e 200 anos de reformas institucionais e administrativas.The passing of 200 years since the transfer of the Portuguese Royal Court for Brazil has generated the realization of innumerable commemorative events, such as seminars, guest speakers, expositions and the publication of books and articles in journals and magazines. However, few findings, discussions and publications about the "200 years" looked to examine the question of the constitution of the national state and the formation of Brazilian public administration. This article intends to fill the large void left in the commemoration of the 200 years since the arrival of the Royal Portuguese Family in Brazil. It offers a quick historical panorama of the transformations that Brazilian public administration experienced

  9. 200 million Euros:Worthy or Not?

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    "Pierre Cardin to Sell Licenses to Chinese Companies with 200 million Euros",frankly speaking,at the first time I knew the news,several questions ran into my mind:"200 million Euros,is it too much for such a not-first-class international fashion brand?","200 millions Euros,with such a large amount of capital,domestic enterprises could gain more investment to develop their own brand?",or"Pierre Cardin…".Although later one of the spokesman of Pierre Cardin Group explained:"This is not about the sale of the Pierre Cardin group,but the sale of certain licenses in China",this hot deal still arouse fierce comments from not only the domestic industrial insiders,but also the publics.

  10. 200-UP-2 operable unit radiological surveys

    International Nuclear Information System (INIS)

    This report summarizes and documents the results of the radiological surveys conducted from August 17 through December 16, 1993 over a partial area of the 200-UP-2 Operable Unit, 200-W Area, Hanford Site, Richland, Washington. In addition, this report explains the survey methodology of the Mobile Surface Contamination Monitor 11 (MSCM-II) and the Ultra Sonic Ranging And Data System (USRADS). The radiological survey of the 200-UP-2 Operable Unit was conducted by the Site Investigative Surveys/Environmental Restoration Health Physics Organization of the Westinghouse Hanford Company. The survey methodology for the majority of area was based on utilization of the MSCM-II or the USRADS for automated recording of the gross beta/gamma radiation levels at or near six (6) inches from the surface soil

  11. S-200防空导弹

    Institute of Scientific and Technical Information of China (English)

    刘明

    2008-01-01

    S-200是苏联于上世纪五、六十年代为对付XB-70超音速战略轰炸机和SR-71超音速侦察机而发展出的一种远程中高空防空导弹系统.北约称之为SA-5“甘蒙”(意译为“腌猪腿”)。苏联在1985年时达到装备的最高峰,竟然装备有130个S-200防空导弹团,发射架1950部。随着更新一代的S-300P和S-300V防空导弹系统的服役。S-200才开始陆续退役。

  12. 200mmx200mm OLED步进投影曝光机%Projective Stepper for 200 mmx200 mm OLED Process

    Institute of Scientific and Technical Information of China (English)

    周畅; 李喜峰

    2012-01-01

    It is an undoubted trend for OLED, especially AMOLED, as the next generation and potential display technology. Since producible or profitable AMOLED process has not been mastered by most display manufacturer, 200 mm x200 mm pilot line is very important and cost-efficient for process research and development. And AMOLED process require tighter CD and Overlay for TFT exposure than TFT-LCD. This paper introduces a novel type of projective stepper, SS B200/10A, for TFT procedure of AMOLED pilot line, which is totally different from proximity exposure tool called aligner. Furthermore testing data and display device show the projective stepper can meet well with requirement of AMOLED process.%有机发光二极管(OLED)尤其是AMOLED由于其独特的性能.其可能成为下一代显示技术。目前AMOLED显示还未达到量产之前.200mmx200mm的研发线对于AMOLED技术工艺验证尤为重要。AMOLED对TFT曝光的要求(CD均匀性、套刻精度等)较TFT—LCD高。基于此,介绍了可用于OLED研发要求的步进投影曝光机SSB200/10A,实测数据及显示器件成功开发表明该设备能够很好地满足AMOLED工艺要求。

  13. Triggering at ISABELLE: the first 200 nanoseconds

    International Nuclear Information System (INIS)

    In a typical experiment, a certain small number of signals will come into an electronics trailer on cables that are as short as possible and have propagation velocities as high as possible. With these signals a fast decision will be made as to whether the rest of the information coming in on the slower, longer cables should be further processed or not. The typical length of time for this decision is 200 ns. In this paper, some of the problems arising during that first 200 ns are confronted, and some examples of attempts to solve those problems are given

  14. 200 North Aggregate Area source AAMS report

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This report presents the results of an aggregate area management study (AAMS) for the 200 North Aggregate Area in the 200 Areas of the US Department of Energy (DOE) Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past practice investigations.

  15. Supercapacitor operating at 200 degrees celsius.

    Science.gov (United States)

    Borges, Raquel S; Reddy, Arava Leela Mohana; Rodrigues, Marco-Tulio F; Gullapalli, Hemtej; Balakrishnan, Kaushik; Silva, Glaura G; Ajayan, Pulickel M

    2013-01-01

    The operating temperatures of current electrochemical energy storage devices are limited due to electrolyte degradation and separator instability at higher temperatures. Here we demonstrate that a tailored mixture of materials can facilitate operation of supercapacitors at record temperatures, as high as 200°C. Composite electrolyte/separator structures made from naturally occurring clay and room temperature ionic liquids, with graphitic carbon electrodes, show stable supercapacitor performance at 200°C with good cyclic stability. Free standing films of such high temperature composite electrolyte systems can become versatile functional membranes in several high temperature energy conversion and storage applications. PMID:23999206

  16. 200 North Aggregate Area source AAMS report

    International Nuclear Information System (INIS)

    This report presents the results of an aggregate area management study (AAMS) for the 200 North Aggregate Area in the 200 Areas of the US Department of Energy (DOE) Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past practice investigations

  17. AED 200 uop course tutorial/uop help

    OpenAIRE

    baily

    2015-01-01

     For more course tutorials visit www.uophelp.com   AED 200 Week 1 DQ1 and DQ2 AED 200 Week 1 CheckPoint Teacher Certification Licensure AED 200 Week 2 CheckPoint Students Social Challenges AED 200 Week 2 CheckPoint Social Justice AED 200 Week 2 Assignment Multicultural Education Scenario AED 200 Week 3 DQ 1 and DQ 2 AED 200 Week 3 CheckPoint School Funding Issues AED 200 Week 4 CheckPoint Religion in Schools AED 200 Week 4 CheckPoint Debat...

  18. 17 CFR 200.54 - Constitutional obligations.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Constitutional obligations... ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.54 Constitutional... against any infringement of the constitutional rights, privileges, or immunities of those who are...

  19. 24 CFR 200.105 - Mortgagor supervision.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgagor supervision. 200.105... supervision. (a) As long as the Commissioner is the insurer or holder of the mortgage, the Commissioner shall... Regulatory Agreement or other instrument granting the Commissioner supervision of the mortgagor....

  20. 49 CFR 200.5 - Applications.

    Science.gov (United States)

    2010-10-01

    ... TRANSPORTATION INFORMAL RULES OF PRACTICE FOR PASSENGER SERVICE § 200.5 Applications. (a) Each application and... apply to the Administrator for an order altering that requirement. Each application shall: (1) List by... application shall: (1) List the facilities for proposed downgrading or disposal; (2) Describe and give...

  1. 24 CFR 200.215 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... Officer. (See § 200.224) (e) Principal. (1) An individual, joint venture, partnership, corporation, trust... includes: (i) Any affiliates of a principal; (ii) if the principal is a partnership, all general partners, and each limited partner having a 25 percent or more interest in the partnership; (iii) if...

  2. 38 CFR 52.200 - Physical environment.

    Science.gov (United States)

    2010-07-01

    ... Register in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. The document incorporated by reference is... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Physical environment. 52...) PER DIEM FOR ADULT DAY HEALTH CARE OF VETERANS IN STATE HOMES Standards § 52.200 Physical...

  3. 30 CFR 217.200 - Audits.

    Science.gov (United States)

    2010-07-01

    ... copies of audit reports that express opinions on such compliance to the Associate Director for Minerals... INSPECTIONS Coal § 217.200 Audits. An audit of the accounts and books of operators/lessees for the purpose of determining compliance with Federal lease terms relating to Federal royalties may be required annually or...

  4. 24 CFR 200.620 - Requirements.

    Science.gov (United States)

    2010-04-01

    ... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.620... marketing responsibility to another party, be responsible for that party's carrying out the requirements: (a... marketing program shall be in effect for each multifamily project throughout the life of the mortgage....

  5. Beyond metric gravity: Progress on PS-200

    International Nuclear Information System (INIS)

    The reconciliation of quantum mechanics and gravity on varying distance scales requires changes to General Relativity that may be testable implications. We briefly review the status of tests with matter of the inverse square law and the principle of equivalence, then report on progress on the drift-tube measurement section of PS- 200, the experiment to measure the gravitational acceleration of antiprotons

  6. 20 CFR 200.6 - Open meetings.

    Science.gov (United States)

    2010-04-01

    ...) Disclose the identity of a confidential source and, in the case of a record compiled by a criminal law...) of this section shall govern in the case of any request under 5 U.S.C. 552 and 20 CFR 200.3 to copy... international tribunal, or an arbitration, or the initiation, conduct, or disposition by the agency of...

  7. 36 CFR 200.8 - Appeals.

    Science.gov (United States)

    2010-07-01

    ... submitted under § 200.7 shall be submitted in accordance with U.S. Department of Agriculture rules at 7 CFR... CFR part 1, subpart A, and the appendix to subpart A. (c) The Forest Service Freedom of Information... Agriculture, Auditors Building, 14th and Independence Avenue, S.W., P.O. Box 96090, Washington, DC...

  8. 19 CFR 200.735-102 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION EMPLOYEE RESPONSIBILITIES AND CONDUCT General Provisions § 200.735-102 Definitions. In this part: (a) Commission means the U.S. International Trade Commission. (b) Commissioner means a Commissioner of the U.S. International Trade Commission. (c)...

  9. 200 Area treated effluent disposal facility operational test report

    International Nuclear Information System (INIS)

    This document reports the results of the 200 Area Treated Effluent Disposal Facility (200 Area TEDF) operational testing activities. These completed operational testing activities demonstrated the functional, operational and design requirements of the 200 Area TEDF have been met

  10. Neuromuscular Fatigue During 200 M Breaststroke

    Directory of Open Access Journals (Sweden)

    Ana Conceição

    2014-03-01

    Full Text Available The aims of this study were: i to analyze activation patterns of four upper limb muscles (duration of the active and non-active phase in each lap of 200m breaststroke, ii quantify neuromuscular fatigue, with kinematics and physiologic assessment. Surface electromyogram was collected for the biceps brachii, deltoid anterior, pectoralis major and triceps brachii of nine male swimmers performing a maximal 200m breaststroke trial. Swimming speed, SL, SR, SI decreased from the 1st to the 3rd lap. SR increased on the 4th lap (35.91 ± 2.99 stroke·min-1. Peak blood lactate was 13.02 ± 1.72 mmol·l-1 three minutes after the maximal trial. The EMG average rectified value (ARV increased at the end of the race for all selected muscles, but the deltoid anterior and pectoralis major in the 1st lap and for biceps brachii, deltoid anterior and triceps brachii in the 4th lap. The mean frequency of the power spectral density (MNF decreased at the 4th lap for all muscles. These findings suggest the occurrence of fatigue at the beginning of the 2nd lap in the 200m breaststroke trial, characterized by changes in kinematic parameters and selective changes in upper limb muscle action. There was a trend towards a non-linear fatigue state.

  11. Os 200 anos da pilha elétrica The 200 years of the electric pile

    Directory of Open Access Journals (Sweden)

    Aécio Pereira Chagas

    2000-06-01

    Full Text Available In celebration of the 200th anniversary of the electric pile, invented by Alessandro Volta, a synopsis of his letter to The Royal Society (London and of his biography is presented.

  12. 1997-1998 Annual Review of the 200 West and 200 East area performance assessments

    International Nuclear Information System (INIS)

    An annual review of the 200 West and 200 East Area Performance Assessment (PA) analyses for fiscal year 1998 was completed. Burial ground disposal operations were found to be compliant with performance objectives in DOE Order 5820.2A. Other newly generated information and analyses relevant to PA assumptions and results were summarized. This report was initially submitted to the Department of Energy-Richland Office (DOE-RL) as a letter report in October, 1998

  13. 13 CFR 108.200 - Adequate capital for NMVC Companies.

    Science.gov (United States)

    2010-01-01

    ... Companies. 108.200 Section 108.200 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Qualifications for the NMVC Program Capitalizing A Nmvc Company § 108.200 Adequate capital for NMVC Companies. You must meet the requirements of §§ 108.200-108.230 in order...

  14. Pediatric esophageal scintigraphy. Results of 200 studies

    Energy Technology Data Exchange (ETDEWEB)

    Guillet, J.; Wynchank, S.; Basse-Cathalinat, B.; Christophe, E.; Ducassou, D.; Blanquet, P.

    1983-09-01

    Esophageal transit of a small volume of watery liquid has been observed scintigraphically in 200 studies performed on patients aged between 6 days and 16 years. Qualitative information concerning esophageal morphology and function in the various phases of deglutition, and scintigraphic features of achalasia, stenosis, and other pathologies are described. Measured esophageal transit time and its normal variation, its relevance to the diagnosis of esophagitis, and the monitoring of treatment are discussed. This technique observing distinct deglutitions has proven a useful diagnostic tool. Its advantages and limitations are discussed in comparison with other methods.

  15. Pediatric esophageal scintigraphy. Results of 200 studies

    International Nuclear Information System (INIS)

    Esophageal transit of a small volume of watery liquid has been observed scintigraphically in 200 studies performed on patients aged between 6 days and 16 years. Qualitative information concerning esophageal morphology and function in the various phases of deglutition, and scintigraphic features of achalasia, stenosis, and other pathologies are described. Measured esophageal transit time and its normal variation, its relevance to the diagnosis of esophagitis, and the monitoring of treatment are discussed. This technique observing distinct deglutitions has proven a useful diagnostic tool. Its advantages and limitations are discussed in comparison with other methods

  16. On sbottom hadronization at LEP 200

    International Nuclear Information System (INIS)

    The question of the hadronization of the sbottom is of interest for experimental searches. A study concerning this feature is presented for masses accessible at LEP 200 assuming that the sbottom is the lightest squark. Numerical evaluations of the decay modes b-bar1 → bX-bar10 and b-bar1 → bX-bar20 are done by varying the SUSY space parameters M2 and μ. The results obtained allow to assert in which conditions the sbottom hadronizes and which decay dominates. (authors)

  17. digitally driven remote manipulator MT200

    International Nuclear Information System (INIS)

    Realization of specifics moves or at regular speed, or repetitive tasks, are ones of the difficulties encountered in the remote-manipulating field. The french Atomic Energy Commission (CEA) made a digital control for the remote-manipulator MT200. The selected solution consists in replacing the master arm by a plate equipped with electrical motors and a computing system. This paper presents the characteristics and functionalities of this control and the several tests for evaluating this system. The easy implementation of this system and the good results allows us to envisage in some sections, the execution of tricky works or the automation of repetitive tasks. (author). 3 figs., 1 tab

  18. Hunting effective LSP at LEP 200

    International Nuclear Information System (INIS)

    Relatively light sneutrinos, which are experimentally allowed, may significantly affect the currently popular search strategies for supersymmetric particles by decaying dominantly into an invisible channel. In certain cases the second lightest neutralino may also decay invisibly leading to two extra carriers of missing energy - in addition to the lightest supersymmetric particle (LSP) Z1 - the effective LSPs (ELSPs). It is shown that these ELSPs are allowed in supergravity models with common scalar and gaugino masses at the unification scale for a sizable region of parameter space and are consistent with all constraints derived so far from SUSY searches. The pair production of right handed sleptons, which can very well be the lightest charged SUSY particles in this scenario, at LEP 200 and their decay signatures are discussed. The signal survives kinematical cuts required to remove the standard model background. Charginos are also pair produced copiously if kinematically accessible; they also decay dominantly into hadronically quiet di-lepton+ET modes leading to interesting unlike sign dilepton events which are again easily separable from the Standard Model backgrounds at LEP 200 energies. (orig.)

  19. Hanford 200 area (sanitary) waste water system

    International Nuclear Information System (INIS)

    The US Department of Energy (DOE) Hanford Site is located in southeastern Washington State. The Hanford Site is approximately 1,450 sq. km (560 sq. mi) of semiarid land set aside for activities of the DOE. The reactor fuel processing and waste management facilities are located in the 200 Areas. Over the last 50 years at Hanford dicard of hazardous and sanitary waste water has resulted in billions of liters of waste water discharged to the ground. As part of the TPA, discharges of hazardous waste water to the ground and waters of Washington State are to be eliminated in 1995. Currently sanitary waste water from the 200 Area Plateau is handled with on-site septic tank and subsurface disposal systems, many of which were constructed in the 1940s and most do not meet current standards. Features unique to the proposed new sanitary waste water handling systems include: (1) cost effective operation of the treatment system as evaporative lagoons with state-of-the-art liner systems, and (2) routing collection lines to avoid historic contamination zones. The paper focuses on the challenges met in planning and designing the collection system

  20. Superhigh-resolution 200ppi series TFT-LCDs; Chokoseisai 200ppi ekisho display series

    Energy Technology Data Exchange (ETDEWEB)

    Kawamata, K.; Hirai, H. [Toshiba Corp., Tokyo (Japan)

    2000-02-01

    We have developed a 202 pixels per inch (ppi) thin-film transistor liquid crystal display (TFT-LCD) using low-temperature polycrystalline silicon (LTPS) technology. The superhigh resolution of 202 ppi offers the same image quality as printed matter such as magazines. The 200 ppi series TFT-LCDs are expected to support further developments in such areas as electronic books (e-books) and personal digital-picture viewers. Our lineup of 200 ppi TFT-LCDs includes a 4-inch display with VGA resolution, which is suitable for palmtop-size applications, and a 6.3-inch display with XGA resolution, which is suitable for typical photograph or paperback book-size applications. Larger size LCDs with 200 ppi resolution will be developed. (author)

  1. Summary of the 200x200 GeV μ+-μ- collider working group

    International Nuclear Information System (INIS)

    We report the discussions and some preliminary results from the sessions of the 200x200 GeV μ+-μ- Collider working group. The physics motivation for such a open-quote open-quote medium-energy close-quote close-quote collider is discussed. Possible parameters for such a system are described, and compared with higher-energy systems. Relatively-high luminosities (L∼1033 cm-2s-1) appear possible. Modifications of existing facilities to obtain medium-energy μ+-μ- collisions are discussed. Other discussion topics (μ-p colliders, low-energy μ sources, etc.) are summarized. copyright 1995 American Institute of Physics

  2. LLNL Site 200 Risk Management Plan

    International Nuclear Information System (INIS)

    2008, has been included as an appendix to the RMP Supplemental Information document. LLNL Site 200 is a research and development laboratory with infrastructure necessary to support its operations and personnel. Research and development activities at LLNL are focused on stockpile stewardship; achieving robust and vital scientific, engineering, and manufacturing capability; inertial confinement fusion; laser technology; materials and process science; computational and information sciences; basic sciences; engineering sciences; and biological sciences. Based upon CalARP Program regulations, guidance found in California Accidental Release Prevention Program (CalARP) Administering Guidance, Chapter 1, a review of facility specific documents, accident analyses summarized in this document and detailed in the LLNL Site 200 RMP Supporting Information document, LLNL has determined that each process meeting the CalARP threshold criteria meets the requirements for CalARP Program Level 1. In accordance with CalARP regulations, LLNL considers the natural segmentation of processes at Site 200 to be on a building basis and therefore consideration of inventory should be on a building basis rather than a 'site-wide' basis. Only those materials identified as equal to as or greater than the threshold quantities for the CalARP program on a building (process) level are reflected in this document. As such, materials and quantities reported in this document on a building (process) level will vary from materials and quantities reported in the LLNL Hazardous Materials Business Plan, Acutely Hazardous Material Registration Form on a site-wide level. For each process involving regulated quantities of lithium hydride, worst case accident analysis shows that the toxic endpoint lies within the site boundaries. These analyses document that the nearest public receptor is beyond the distance to a toxic or flammable endpoint. Refer to the LLNL Site 200 RMP Supporting Information document for a more

  3. 40 CFR 246.200 - High-grade paper recovery.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false High-grade paper recovery. 246.200 Section 246.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE... paper recovery....

  4. Earth Surface Patterns in 200 Years (Invited)

    Science.gov (United States)

    Werner, B.

    2009-12-01

    What kinds of patterns will characterize Earth's surface in 200 years? This question is addressed using a complex systems dynamical framework for distinct levels of description in a hierarchy, in which time scale and spatial extent increase and number of variables decrease with level, and in which levels are connected nonlinearly to each other via self-organization and slaving and linearly to the external environment. Self-organized patterns linking the present to 200 years in the future must be described dynamically on a level with a time scale of centuries. Human-landscape coupling will play a prominent role in the formation of these patterns as population peaks and interactions become nonlinear over these time scales. Three related examples illustrate this approach. First, the response of human-occupied coastlines to rising sea level. Coastlines in wealthy regions develop a spatially varying boom and bust pattern, with response amplified by structures meant to delay the effects of sea level rise. Coastlines in economically disadvantaged regions experience a subdued response, with populations developing a culture of displacement that minimizes human-landscape interactions in a context of scarce resources. Second, the evolution of nation-state borders with degrading ecosystems, declining resource availability and increasing transportation costs. The maintenance of strong borders as selective filtration systems (goods, capital and people) is based on a cost-benefit analysis in which the economic benefits accruing from long distance, globalized resource exploitation are weighed against policing and infrastructure costs. As costs rise above benefits, borders fragment, with a transition to local barriers and conflicts, and mobile peoples moving to resources. Third, trends in urbanization and development of megacities under economic and environmental stress. The pattern of rapid growth of megacities through inward migration, with displaced people occupying high

  5. Ore-turbidity gamma densimeter GTM-200

    International Nuclear Information System (INIS)

    The device is designed for measuring ore turbidity through the pipe walls, without any contact with the measured fluid. The measuring principle is based on the attenuation of gamma beam intensity across a homogeneous medium. The facility consists of a measuring block, mounted on the pipe carrying the fluid whose density is to be measured and a display block which gives the measured density in g/cm3. The measuring block is made up of an emitter equipped with a Cs 137 radiation source and a receiver. The operational and technical features and components of the system are: - Leaden emitter; - Radioactive source: Cs-137; - Measuring range: 1 - 2.1g/cm3; - Maximum admitted error across measuring range: ±1.5% of real conventional value; - Average response time: 30 seconds; - Power supply: 220 V ac±10%; 50 Hz; - Ambient temperature: - 10 deg. C to + 40 deg. C; - Pipe diameter: 80 mm - 200 mm; - Receiver shielding level: IP 65; - Display-transmitter shielding level: IP 54; - Display-transmitter output signal: 4 - 20 mA for a preset measuring sub-range; - Receiver to display-transmitter wire length: 30 m. (authors)

  6. Laparoscopic Cholecystectomy: An Experience of 200 cases

    Directory of Open Access Journals (Sweden)

    Sanjay K. Bhasin, J.G. Langer.

    2004-04-01

    Full Text Available The surgical management of gallstones has been revolutionized after the advent of laparoscopiccholecystectomysince 1985/87. This minimally invasive technique has virtually become the goldstandard in the management of cholelithiasis. We share our experience of 200 cases of laparoscopiccholecystectomyperformed in symptomatic cholelithiasis over a period of five years from 1998 to2002 in Govt. Medical College, Jammu. There were 32 males and 168 females in the study group.Maximum age of the patients was 65-yr and minimum 17-yr. Patients with high-risk medical problems;deranged LFT, CBD stones and acute cholecystitis were excluded from this study. Average operationtime was 61.3 minute (40-130 mt, post-operative analgesic used were 3.02 doses per patient (2-15doses, post-operative hospital stay was 4.34 days (2-26 days and time to return to work was 13.2days (10-40 days. Rate of conversion to conventional-cholecystectomy was 4%. There was nomortality and negligible/acceptable morbidity. No complications were observed in the follow up periodranging from 2 weeks to 6 months. The patients were quite satisfied with the outcome of the procedure.

  7. Dynamic behaviour of S200F beryllium

    International Nuclear Information System (INIS)

    Compression tests have been made on a large scale of strain, strain rate (up to 2000 s-1) and temperature (between 20 C and 300 C). From these experiences, we have calculated a constitutive model for beryllium S200F, which can be used by computer codes. Its formulation is not far from Steinberg, Cochran and Guinan's. But in our case, the influences of temperature and strain rate appear clearly within the expression. To validate our equation, we have used it in a computer code. Its extrapolation for higher strain rates is in good agreement with experiments such as Taylor impact tests or plate impact tests (strain rates greater than 104 s-1). With micrography, we could settle a link between the main strain mode within the material, and the variation of one parameter of the model. Beside the constitutive model, we have shown that shock loaded beryllium behaves in two different ways. If the strain rate is lower than 5.106 s-1, then it is proportional to the squared shock pressure. Beyond, it is a linear function of shock pressure to the power of four. By a spall study on beryllium, we have confirmed that it is excessively fragile. Its fracture is sudden, at a strength near 1 GPa. (author)

  8. 34 CFR 200.57 - Plans to increase teacher quality.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Plans to increase teacher quality. 200.57 Section 200... Paraprofessionals § 200.57 Plans to increase teacher quality. (a) State plan. (1) A State that receives funds under... ensure that all public elementary and secondary school teachers in the State who teach core...

  9. 40 CFR 246.200-7 - Recommended procedures: Transportation.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommended procedures: Transportation. 246.200-7 Section 246.200-7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 246.200-7 Recommended procedures: Transportation. Transportation to market may be supplied by...

  10. 21 CFR 137.200 - Whole wheat flour.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Whole wheat flour. 137.200 Section 137.200 Food... Flours and Related Products § 137.200 Whole wheat flour. (a) Whole wheat flour, graham flour, entire wheat flour is the food prepared by so grinding cleaned wheat, other than durum wheat and red...

  11. 200 area effluent treatment facility opertaional test report

    International Nuclear Information System (INIS)

    This document reports the results of the 200 Area Effluent Treatment Facility (200 Area ETF) operational testing activities. These Operational testing activities demonstrated that the functional, operational and design requirements of the 200 Area ETF have been met and identified open items which require retesting

  12. 40 CFR 246.200-3 - Recommended procedures: Market study.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommended procedures: Market study. 246.200-3 Section 246.200-3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 246.200-3 Recommended procedures: Market study. An investigation of markets should be made by...

  13. 24 CFR 200.153 - Presentation of claim.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Presentation of claim. 200.153 Section 200.153 Housing and Urban Development Regulations Relating to Housing and Urban Development... Claims for Losses § 200.153 Presentation of claim. In the event the insured lender is entitled under...

  14. Limited field investigation for the 200-UP-1 operable unit

    International Nuclear Information System (INIS)

    The 200-UP-1 Groundwater Operable Unit is located in the southern portion of the 200 West Area on the Hanford Site in Washington State. The operable unit is located adjacent to the 200-ZP-1 Groundwater Operable Unit and underlies a significant part of seven source operable units: 200-RO-1, 200-RO-2, 200-RO-3, 200-RO-4, 200-SS-2, 200-UP-2, and 200-UP-3. Remedial efforts in the 100-ZP-1 Operable Unit focus on addressing volatile organic contamination in the aquifer. The focus of the 200-UP-1 limited field investigation (LFI) is on contaminated aquifer soils and groundwater within its boundary, with the exception of uranium and technetium-99 plumes, which are addressed by an existing 200-UP-1 interim remedial measure (IRM). The LFI approach is driven by general and specific data needs required to refine the site conceptual model and conduct a risk assessment. Activities supporting the LFI include drilling, well construction, sampling and analysis, data validation, geologic and geophysical logging, aquifer testing, measuring depth to water, and evaluating geodetic survey and existing analytical data

  15. 200 Area Interim Storage Area Technical Safety Requirements

    International Nuclear Information System (INIS)

    The 200 Area Interim Storage Area Technical Safety Requirements define administrative controls and design features required to ensure safe operation during receipt and storage of canisters containing spent nuclear fuel. This document is based on the 200 Area Interim Storage Area, Annex D, Final Safety Analysis Report which contains information specific to the 200 Area Interim Storage Area

  16. 29 CFR 2530.200b-6 - Maritime industry.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Maritime industry. 2530.200b-6 Section 2530.200b-6 Labor... Provisions § 2530.200b-6 Maritime industry. (a) General. Sections 202(a)(3)(D), 203(b)(2)(D) and 204(b)(3)(E... provisions applicable to the maritime industry. In general, those provisions permit statutory...

  17. 17 CFR 200.72 - Supervision of internal organization.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Supervision of internal organization. 200.72 Section 200.72 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.72 Supervision...

  18. 34 CFR 200.91 - SEA counts of eligible children.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false SEA counts of eligible children. 200.91 Section 200.91... Prevention and Intervention Programs for Children and Youth Who are Neglected, Delinquent, or At-Risk of Dropping Out § 200.91 SEA counts of eligible children. To receive an allocation under part D, subpart 1...

  19. 10 CFR 72.200 - Provision of MRS information.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Provision of MRS information. 72.200 Section 72.200 Energy... MRS Information to State Governments and Indian Tribes § 72.200 Provision of MRS information. (a) The... Governor and legislature of any State in which an MRS authorized under the Nuclear Waste Policy Act of...

  20. 17 CFR 200.26a - Office of Information Technology.

    Science.gov (United States)

    2010-04-01

    ... Organization § 200.26a Office of Information Technology. The Office of Information Technology is responsible... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Office of Information Technology. 200.26a Section 200.26a Commodity and Securities Exchanges SECURITIES AND EXCHANGE...

  1. 200 area effluent treatment facility opertaional test report

    Energy Technology Data Exchange (ETDEWEB)

    Crane, A.F.

    1995-10-26

    This document reports the results of the 200 Area Effluent Treatment Facility (200 Area ETF) operational testing activities. These Operational testing activities demonstrated that the functional, operational and design requirements of the 200 Area ETF have been met and identified open items which require retesting.

  2. 34 CFR 200.6 - Inclusion of all students.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Inclusion of all students. 200.6 Section 200.6 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY... Basic Programs Operated by Local Educational Agencies Standards and Assessments § 200.6 Inclusion of...

  3. 12 CFR 563.200 - Conflicts of interest.

    Science.gov (United States)

    2010-01-01

    ...-OPERATIONS Reporting and Bonding § 563.200 Conflicts of interest. If you are a director, officer, or employee... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Conflicts of interest. 563.200 Section 563.200... savings association; and (b) You must, if you have an interest in a matter or transaction before the...

  4. 19 CFR 200.735-103 - Counseling service.

    Science.gov (United States)

    2010-04-01

    ... specific program elements listed in Office of Government Ethics regulations, 5 CFR 738.203(b). ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Counseling service. 200.735-103 Section 200.735... General Provisions § 200.735-103 Counseling service. (a) The Chairman shall appoint a Designated...

  5. Limited field investigation for the 200-UP-1 operable unit

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    The 200-UP-1 Groundwater Operable Unit is located in the southern portion of the 200 West Area on the Hanford Site in Washington State. The operable unit is located adjacent to the 200-ZP-1 Groundwater Operable Unit and underlies a significant part of seven source operable units: 200-RO-1, 200-RO-2, 200-RO-3, 200-RO-4, 200-SS-2, 200-UP-2, and 200-UP-3. Remedial efforts in the 100-ZP-1 Operable Unit focus on addressing volatile organic contamination in the aquifer. The focus of the 200-UP-1 limited field investigation (LFI) is on contaminated aquifer soils and groundwater within its boundary, with the exception of uranium and technetium-99 plumes, which are addressed by an existing 200-UP-1 interim remedial measure (IRM). The LFI approach is driven by general and specific data needs required to refine the site conceptual model and conduct a risk assessment. Activities supporting the LFI include drilling, well construction, sampling and analysis, data validation, geologic and geophysical logging, aquifer testing, measuring depth to water, and evaluating geodetic survey and existing analytical data.

  6. 34 CFR 303.200 - Formula for State allocations.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Formula for State allocations. 303.200 Section 303.200 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... TODDLERS WITH DISABILITIES Procedures for Making Grants to States § 303.200 Formula for State...

  7. 34 CFR 200.34 - Identification for restructuring.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Identification for restructuring. 200.34 Section 200.34... for restructuring. (a) If a school continues to fail to make AYP after one full school year of corrective action under § 200.42, the LEA must prepare a restructuring plan for the school and...

  8. 7 CFR 948.200 - Accounting and collections.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Accounting and collections. 948.200 Section 948.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Accounting and Collections § 948.200 Accounting and collections. (a) Each handler's assessment account...

  9. 34 CFR 200.5 - Timeline for assessments.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Timeline for assessments. 200.5 Section 200.5 Education... Programs Operated by Local Educational Agencies Standards and Assessments § 200.5 Timeline for assessments... least once in grades 10 through 12. (3) The Secretary may extend, for one additional year, the...

  10. PM200/PS200: Self-Lubricating Bearing and Seal Materials for Applications to 900 C

    Science.gov (United States)

    Sliney, Harold E.

    1991-01-01

    The development of the PS/PM200 class of self-lubricating material is described. The composition of the materials and their performance under temperature conditions from minus 160 degrees to 900 C (minus 250 to 1650 F) are examined. Applications in areas such as cylinder liner coatings, shaft seals, gas bearings, and airframe thermal expansion joints are proposed. Graphs and tables are provided to show service temperature limits, mechanical strength, linear thermal expansion, and thermal conductivity parameters.

  11. 200-BP-5 operable unit treatability test report

    International Nuclear Information System (INIS)

    The 200-BP-5 Operable Unit was established in response to recommendations presented in the 200 East Groundwater Aggregate Area Management Study Report (AAMSR) (DOE-RL 1993a). Recognizing different approaches to remediation, the groundwater AAMSR recommended separating groundwater from source and vadose zone operable units and subdividing 200 East Area groundwater into two operable units. The division between the 200-BP-5 and 200-PO-1 Operable Units was based principally on source operable unit boundaries and distribution of groundwater plumes derived from either B Plant or Plutonium/Uranium Extraction (PUREX) Plant liquid waste disposal sites

  12. VASIMR VX-200 thruster throttling optimization from 30 to 200 kW

    Science.gov (United States)

    Squire, Jared; Olsen, Chris; Chang-Diaz, Franklin; Longmier, Benjamin; Ballenger, Maxwell; Carter, Mark; Glover, Tim; McCaskill, Greg

    2012-10-01

    The VASIMR^ VX-200 experimental plasma thruster incorporates a 40 kW helicon plasma source with a 180 kW Ion Cyclotron Heating (ICH) acceleration stage integrated in a superconducting magnet. Argon propellant mass flow is injected up to 140 mg/s. Rapid plasma start up ( 10^5 liters/s) in a 150 m^3 vacuum chamber achieve performance measurements with the charge exchange mean-free-path greater than 1 m in the background neutral gas (pressure efficiency at 200 kW total power is 72 ± 9%, the ratio of effective jet power to input RF power, with an Isp = 4900 ± 300 seconds (flow velocity of 49 km/s), and an ion flux of 1.7 ± 0.1 x 10^21/s. The thrust increases steadily with power to 5.8 ± 0.4 N until the power is maximized and there is no indication of saturation. The plasma density near the device exit exceeds 10^18 m-3 with a power density over 5 MW/m^2. An extensive study of thruster performance, efficiency and thrust-to-power ratio, as a function of Ar propellant flow rate and ICH-to-helicon RF power ratio has been carried out over a total power range of 30 to 200 kW. Optimized throttling set points are determined. The experimental configuration and results of this study are presented.

  13. Neutral Wind Observations below 200 km altitudes

    Science.gov (United States)

    Watanabe, S.; Abe, T.; Habu, H.; Kakinami, Y.; Larsen, M. F.; Pfaff, R. F., Jr.; Yamamoto, M.

    2015-12-01

    Neutral Wind Observations below 200 km altitudesS. Watanabe1, T. Abe2, H. Habu2, Y. Kakinami3, M. Larsen4, R. Pfaff5, M. Yamamoto6, M-Y. Yamamoto31Hokkaido University/Hokkaido Information University, 2JAXA/ISAS, 3Kochi University of Technology, 4Clemson University, 5NASA/Goddard Space Flight Center, 6Kyoto University, Neutral wind in the thermosphere is one of the key parameters to understand the ionosphere-thermosphere coupling process. JAXA/ISAS successfully launched sounding rockets from Uchinoura Space Center (USC) on September 2, 2007, January 12, 2012, and July 20, 2013, and NASA launched sounding rockets from Kwajalein on May 7, 2013 and from Wallops on July 4, 2013. The rockets installed Lithium and/or TMA canisters as well as instruments for plasma and electric and magnetic fields. The atomic Lithium gases were released at altitudes between 150 km and 300 km in the evening on September 2, 2007, at altitude of ~100 km in the morning on January 12, 2012, at altitude of ~120km in the midnight on July 20, 2013, at altitude between 150 km and 300 km in the evening on May 7, 2013 and at altitude of ~150 km in the noon on July 4, 2013. The Lithium atoms were scattering sunlight by resonance scattering with wavelength of 670nm. However, the Lithium atoms scattered moon light on July 20, 2013. The moon light scattering is the first time to use for thermospheric wind measurement in the midnight. The Lithium clouds/trails and TMA trails showed clearly the neutral wind shears and atmospheric waves at ~150 km altitude in the lower thermosphere for all local time.

  14. Astatination of closo-dodecaborate(2-) anion

    Czech Academy of Sciences Publication Activity Database

    Orlova, A.; Lebeda, Ondřej; Tolmachev, V.; Lundquist, H.; Carlsson, J.; Sjöberg, S.

    Cambridge : The Royal Society of Chemistry , 2000 - (Davidson, M.; Hughes, A.; Marder, T.; Wade , K.), s. 144-147 [Conference "Contemporary Boron Chemistry ". Durham (GB), 11.07.1999-15.07.1999] Institutional research plan: CEZ:AV0Z1048901 Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  15. State Waste Discharge Permit application: 200-E Powerhouse Ash Pit

    Energy Technology Data Exchange (ETDEWEB)

    Atencio, B.P.

    1994-06-01

    As part of the Hanford Federal Facility Agreement and Consent Order negotiations, the US Department and Energy, Richland Operations Office, the US Environmental Protection Agency, and the Washington State Department of Ecology agreed that liquid effluent discharges to the ground on the Hanford Site which affect groundwater or have the potential to affect groundwater would be subject to permitting under the structure of Chapter 173-216 (or 173-218 where applicable) of the Washington Administrative Code, the State Waste Discharge Permit Program. This document constitutes the State Waste Discharge Permit application for the 200-E Powerhouse Ash Pit. The 200-E Powerhouse Ash Waste Water discharges to the 200-E Powerhouse Ash Pit via dedicated pipelines. The 200-E Ash Waste Water is the only discharge to the 200-E Powerhouse Ash Pit. The 200-E Powerhouse is a steam generation facility consisting of a coal-handling and preparation section and boilers.

  16. Super high precision 200 ppi liquid crystal display series; Chokoseido 200 ppi ekisho display series

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    In mobile equipment, in demand is a high precision liquid crystal display (LCD) having the power of expression equivalent to printed materials like magazines because of the necessity of displaying a large amount of information on a easily potable small screen. In addition, with the spread and high-quality image of digital still cameras, it is strongly desired to display photographed digital image data in high quality. Toshiba Corp., by low temperature polysilicone (p-Si) technology, commercialized the liquid crystal display series of 200 ppi (pixels per inch) precision dealing with the rise of the high-precision high-image quality LCD market. The super high precision of 200 ppi enables the display of smooth beautiful animation comparable to printed sheets of magazines and photographs. The display series are suitable for the display of various information services such as electronic books and electronic photo-viewers including internet. The screen sizes lined up are No. 4 type VGA (640x480 pixels) of a small pocket notebook size and No. 6.3 type XGA (1,024x768 pixels) of a paperback size, with a larger screen to be furthered. (translated by NEDO)

  17. 21 CFR 73.200 - Synthetic iron oxide.

    Science.gov (United States)

    2010-04-01

    ... million. Mercury (as Hg) , not more than 1 part per million. (2) Synthetic iron oxide for dog and cat food... food. (2) Synthetic iron oxide may be safely used for the coloring of dog and cat foods in an amount... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Synthetic iron oxide. 73.200 Section 73.200...

  18. 17 CFR 200.27 - The Regional Directors.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false The Regional Directors. 200.27... § 200.27 The Regional Directors. Each Regional Director is responsible for executing the Commission's... matters, by the Deputy Director of the Division of Enforcement who is responsible for Regional...

  19. 20 CFR 627.200 - Governor/Secretary agreement.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Governor/Secretary agreement. 627.200 Section... PROVISIONS GOVERNING PROGRAMS UNDER TITLES I, II, AND III OF THE ACT Program Requirements § 627.200 Governor/Secretary agreement. (a)(1) To establish a continuing relationship under the Act, the Governor and...

  20. 40 CFR 747.200 - Triethanolamine salt of tricarboxylic acid.

    Science.gov (United States)

    2010-07-01

    ...-1005) has been regulated by the Environmental Protection Agency, at 40 CFR 747.200, as published in the... regulated by the Environmental Protection Agency (40 CFR 747.200 published in the Federal Register of... lubricating. (3) Nitrosating agent means any substance that has the potential to transfer a nitrosyl...

  1. 21 CFR 522.1125 - Hemoglobin glutamer-200 (bovine).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Hemoglobin glutamer-200 (bovine). 522.1125 Section... § 522.1125 Hemoglobin glutamer-200 (bovine). (a) Specifications. Each 125 milliliter bag contains 13 grams per deciliter of polymerized hemoglobin of bovine origin in modified Lactated Ringer's...

  2. 19 CFR 200.735-118 - Interests of employees' relatives.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Interests of employees' relatives. 200.735-118 Section 200.735-118 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION EMPLOYEE RESPONSIBILITIES... of an employee's immediate household means those blood relations who are residents of the...

  3. 7 CFR 1437.108-1437.200 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false 1437.108-1437.200 Section 1437.108-1437.200 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS NONINSURED CROP DISASTER ASSISTANCE...

  4. 21 CFR 176.200 - Defoaming agents used in coatings.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Defoaming agents used in coatings. 176.200 Section 176.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... quantity of defoaming agent or agents used shall not exceed the amount reasonably required to...

  5. 34 CFR 200.19 - Other academic indicators.

    Science.gov (United States)

    2010-07-01

    ... must report under section 1111(h) of the Act (annual report cards) performance on the academic... 34 Education 1 2010-07-01 2010-07-01 false Other academic indicators. 200.19 Section 200.19... EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED...

  6. 17 CFR 200.111 - Prohibitions; application; definitions.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Prohibitions; application; definitions. 200.111 Section 200.111 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Code of Behavior Governing Ex Parte Communications Between Persons Outside...

  7. 24 CFR 200.55 - Financing fees and charges.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Financing fees and charges. 200.55 Section 200.55 Housing and Urban Development Regulations Relating to Housing and Urban Development... Financing fees and charges. Fees and charges approved by the Commissioner in excess of the initial...

  8. 24 CFR 92.200 - Private-public partnership.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Private-public partnership. 92.200... Development HOME INVESTMENT PARTNERSHIPS PROGRAM Program Requirements § 92.200 Private-public partnership... private sector in accordance with section 221 of the Act....

  9. 40 CFR 246.200-6 - Recommended procedures: Storage.

    Science.gov (United States)

    2010-07-01

    ....200-6 Section 246.200-6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE SEPARATION FOR MATERIALS RECOVERY GUIDELINES Requirements and Recommended Procedures § 246..., the use of stationary compactors, or storage in corrugated boxes or normal waste containers....

  10. 49 CFR 179.200-11 - Postweld heat treatment.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Postweld heat treatment. 179.200-11 Section 179.200-11 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... Postweld heat treatment. When specified in § 179.201-1, after welding is complete, postweld heat...

  11. 34 CFR 200.20 - Making adequate yearly progress.

    Science.gov (United States)

    2010-07-01

    ... paragraph (c)(1)(i) of this section if they take— (A) Either an assessment of English language proficiency under § 200.6(b)(3) or the State's reading/language arts assessment under § 200.2; and (B) The State's... English proficient students on the mathematics assessment, the reading/language arts assessment...

  12. 29 CFR 1926.200 - Accident prevention signs and tags.

    Science.gov (United States)

    2010-07-01

    ... reference in accordance with 5 U.S.C. 552(a) and 1 CFR part 51. You may obtain a copy of the Millennium... 29 Labor 8 2010-07-01 2010-07-01 false Accident prevention signs and tags. 1926.200 Section 1926... § 1926.200 Accident prevention signs and tags. (a) General. Signs and symbols required by this...

  13. 34 CFR 200.60 - Expenditures for professional development.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Expenditures for professional development. 200.60... Paraprofessionals § 200.60 Expenditures for professional development. (a)(1) Except as provided in paragraph (a)(2... professional development activities to ensure that teachers and paraprofessionals meet the requirements...

  14. 15 CFR 200.103 - Consulting and advisory services.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Consulting and advisory services. 200.103 Section 200.103 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... opportunity of laboratory observation and informal discussion. A brochure describing the current series...

  15. 21 CFR 200.50 - Ophthalmic preparations and dispensers.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Ophthalmic preparations and dispensers. 200.50... (CONTINUED) DRUGS: GENERAL GENERAL Requirements for Specific Classes of Drugs § 200.50 Ophthalmic... intended for ophthalmic use, including preparations for cleansing the eyes, should be sterile. It...

  16. Exceptional results from, and status of, EXO-200

    Science.gov (United States)

    Smith, Erica; EXO-200 Collaboration

    2015-10-01

    EXO-200 has provided one of the most sensitive searches for neutrinoless double-beta decay utilizing 175 kg of enriched liquid xenon in an ultra-low background time projection chamber. This detector has demonstrated excellent energy resolution and background rejection capabilities. Using the first two years of data, EXO-200 has set a limit of 1 . 1 ×1025 y at 90% C.L. on the neutrinoless double-beta decay half-life of Xe136. The experiment has experienced a brief hiatus in data taking during a temporary shutdown of its host facility: the Waste Isolation Pilot Plant. EXO-200 expects to resume data taking in earnest this fall with upgraded detector electronics. Results from the analysis of EXO-200 data and an update on the current status of EXO-200 will be presented.

  17. Waste site grouping for 200 Areas soil investigations

    International Nuclear Information System (INIS)

    The purpose of this document is to identify logical waste site groups for characterization based on criteria established in the 200 Areas Soil Remediation Strategy (DOE-RL 1996a). Specific objectives of the document include the following: finalize waste site groups based on the approach and preliminary groupings identified in the 200 Areas Soil Remediation Strategy; prioritize the waste site groups based on criteria developed in the 200 Areas Soil Remediation Strategy; select representative site(s) that best represents typical and worse-case conditions for each waste group; develop conceptual models for each waste group. This document will serve as a technical baseline for implementing the 200 Areas Soil Remediation Strategy. The intent of the document is to provide a framework, based on waste site groups, for organizing soil characterization efforts in the 200 Areas and to present initial conceptual models

  18. 21 CFR 200.200 - Prescription drugs; reminder advertisements and reminder labeling to provide price information to...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Prescription drugs; reminder advertisements and... Prescription Drug Consumer Price Listing § 200.200 Prescription drugs; reminder advertisements and reminder labeling to provide price information to consumers. (a) Prescription drug reminder advertisements...

  19. Tier II Analysis of Vadose Zone Sediments from UPRS 200-E-81 and 200-E-86

    Energy Technology Data Exchange (ETDEWEB)

    Valenta, Michelle M.; Geiszler, Keith N.; Bjornstad, Bruce N.; Schaef, Herbert T.; Brown, Christopher F.

    2009-04-01

    The overall goals of the Tank Farm Vadose Zone Project, led by Washington River Protection Solutions, are to define risks from past and future single-shell tank farm activities; identify and evaluate the efficacy of interim measures; and aid, via collection of geochemical information and data, the future decisions that must be made by the U.S. Department of Energy (DOE) regarding the near-term operations, future waste retrieval, and final closure activities for the single-shell tank waste management areas (WMAs). To meet the investigative goals of the Tank Farm Vadose Zone Project, the Environmental Sciences Laboratory performed geochemical analyses on vadose zone sediments collected within Waste Management Area C. Tier one analyses of UPR-200-E-86, which includes direct push probe holes C5952, C5958 and C5960, were performed between 3/25/08 and 4/14/08. Preliminary results were presented to CH2M Hill Hanford Group on 6/5/08. As a result of the tier one investigations, further tier two analyses were requested. Tier two investigations include particle size and mineralogy analyses on samples collected between 80 to 120 feet below ground surface that were found to contain high concentrations of chloride and sulfate. Tier one analyses on sediments retrieved near UPR-200-E-81, direct push probe hole C6394, were performed between 6/20/08 and 7/22/08. Preliminary results of the tier one analyses were presented on 8/15/08. As a result of the tier one investigations, further tier two analyses were requested. Tier two analyses include determining whether U-236 exists in samples at approximately 42 feet below the ground surface. Confirmation of U-236 will determine whether the U-238 seen in the leaches performed on samples at that depth is a result of contamination and not from leaching natural uranium. Using the water and acid extract U-238 concentrations from the tier one analysis, equilibrium Kd values were requested to be calculated. Additional tier two analysis includes

  20. Color Hawaii Shaded Relief ? 200-Meter Resolution - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The NED...

  1. 15 CFR 270.200 - Technical conduct of investigation.

    Science.gov (United States)

    2010-01-01

    ... NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NATIONAL CONSTRUCTION SAFETY TEAMS NATIONAL CONSTRUCTION SAFETY TEAMS Investigations § 270.200 Technical conduct of investigation. (a) Preliminary reconnaissance. (1) An initial assessment of the event, including an initial site...

  2. 49 CFR 599.200 - Registration of participating dealers.

    Science.gov (United States)

    2010-10-01

    ... preclude a dealer registered under other franchise agreements from receiving a credit for transactions... Section 599.200 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY... funds; (5) The ability to submit application materials and perform transactions electronically using...

  3. Grayscale Hawaii Shaded Relief ? 200-Meter Resolution - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The...

  4. Physics capabilities of the second stage Baikal detector NT-200

    Energy Technology Data Exchange (ETDEWEB)

    Spiering, C.; Heller, R.; Heukenkamp, H.; Krabi, J.; Mikolajski, T.; Thon, T.; Wischnewski, R. [Institut fuer Hochenergiephysik, Zeuthen (Germany); Alatin, S.D.; Fialkovsky, S.V.; Kulepov, V.F.; Milenin, M.B. [Polytechnical Inst., Nizhni Novgorod (Russia); Belolaptikov, I.A.; Bezrukov, L.B.; Borisovets, B.A.; Bugaev, E.V.; Djilkibaev, Zh.A.M.; Domogatsky, G.V.; Donskich, L.A.; Doroshenko, A.A.; Galperin, M.D.; Gushtan, M.N.; Klabukov, A.M.; Klimushin, S.I.; Lanin, O.J.; Lubsandorzhiev, B.K.; Ogievietzky, N.V.; Panfilov, A.I.; Sokalsky, I.A.; Trofimenko, I.I. [Inst. for Nuclear Research, Moscow (Russia); Budnev, N.M.; Chensky, A.G.; Dobrynin, V.I.; Gress, O.A.; Koshechkin, A.P.; Lanin, J.B.; Litunenko, G.A.; Lopin, A.L.; Naumov, V.A.; Nemchenko, M.I.; Parfenov, Yu.V.; Pavlov, A.A.; Pokalev, O.P.; Primin, V.A.; Sumanov, A.A.; Tarashansky, V.A.; Zurbanov, V.L. [Irkutsk State Univ. (Russia); Dudkin, G.N.; Egorov, V.Yu.; Lukanin, A.A.; Ovcharov, A.M.; Padalko, V.M.; Padusenko, A.H. [Tomsk Polytechnical Inst. (Russia); Golikov, A.V.; Kabikov, V.B.; Kuzmichov, L.A.; Osipova, E.A.; Zaslavskaya, E.S. [Moscow State Univ. (Russia); Jenek, L.; Kiss, D.; Tanko, L. [Central Research Inst. of Fundamental Physics, Budapest (Hungary)]|[Joint Inst. for Nuclear Research, Dubna (Russia); Kusner, Yu.S.; Poleschuk, V.A.; Sherstyankin, P.P. [Limnological Inst., Irkutsk (Russia); Levin, A.A.; Nikiforov, A.I.; Rosanov, M.I. [Marine Technical Univ., St. Petersburg (Russia); BAIKAL Collaboration

    1991-12-01

    We describe the lake Baikal deep underwater detector `NT-200` and discuss its physics capabilities to investigate problems in the field of neutrino astrophysics, cosmic ray physics and particle physics. (orig.).

  5. 29 CFR 541.200 - General rule for administrative employees.

    Science.gov (United States)

    2010-07-01

    ...-manual work directly related to the management or general business operations of the employer or the... OUTSIDE SALES EMPLOYEES Administrative Employees § 541.200 General rule for administrative employees....

  6. Physics capabilities of the second stage Baikal detector NT-200

    International Nuclear Information System (INIS)

    We describe the lake Baikal deep underwater detector 'NT-200' and discuss its physics capabilities to investigate problems in the field of neutrino astrophysics, cosmic ray physics and particle physics. (orig.)

  7. 42 CFR 447.200 - Basis and purpose.

    Science.gov (United States)

    2010-10-01

    ...) MEDICAL ASSISTANCE PROGRAMS PAYMENTS FOR SERVICES Payment Methods: General Provisions § 447.200 Basis and purpose. This subpart prescribes State plan requirements for setting payment rates to implement, in...

  8. 24 CFR 401.200 - Who may be a PAE?

    Science.gov (United States)

    2010-04-01

    ...-MARKET) Participating Administrative Entity (PAE) and Portfolio Restructuring Agreement (PRA) § 401.200 Who may be a PAE? A PAE must qualify under the definition in section 512(10) of MAHRA. It must...

  9. 17 CFR 200.41 - Quorum of the Commission.

    Science.gov (United States)

    2010-04-01

    ...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Disposition of Commission Business § 200.41 Quorum of the... office; and provided further that on any matter of business as to which the number of members in...

  10. Grayscale Alaska Shaded Relief ? 200-Meter Resolution - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The...

  11. Thermal-hydraulic design of the 200 MW NHR

    International Nuclear Information System (INIS)

    The thermal hydraulic design of the 200-MW Nuclear Heating Reactor (NHR), design criteria, design methods, important characteristics and some development results are presented in this paper. (author). 5 refs, 8 figs, 2 tabs

  12. 1992 County Pesticide Use Estimates for 200 Compounds

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset includes information for 200 pesticides on the average amount (pounds) applied to 87 agricultural crops and the acres of crops treated for counties...

  13. Characterization of Large Area APDs for the EXO-200 Detector

    Energy Technology Data Exchange (ETDEWEB)

    Neilson, R.; LePort, F.; Pocar, A.; /Stanford U., Phys. Dept.; Kumar, K.; /Massachusetts U., Amherst; Odian, A.; Prescott, C.Y.; /SLAC; Tenev, V.; /Stanford U., Phys. Dept.; Ackerman, N.; /SLAC; Akimov, D.; /Moscow, ITEP; Auger, M.; /Bern U., LHEP; Benitez-Medina, C.; /Colorado State U.; Breidenbach, M.; /SLAC; Burenkov, A.; /Moscow, ITEP; Conley, R.; /SLAC; Cook, S.; /Colorado State U.; deVoe, R.; Dolinski, M.J.; /Stanford U., Phys. Dept.; Fairbank, W., Jr.; /Colorado State U.; Farine, J.; /Laurentian U.; Fierlinger, P.; Flatt, B.; /Stanford U., Phys. Dept. /Bern U., LHEP /Stanford U., Phys. Dept. /Maryland U. /Colorado State U. /Laurentian U. /Carleton U. /SLAC /Maryland U. /Moscow, ITEP /Alabama U. /SLAC /Colorado State U. /Stanford U., Phys. Dept. /Alabama U. /Stanford U., Phys. Dept. /Alabama U. /SLAC /Carleton U. /SLAC /Maryland U. /Moscow, ITEP /Carleton U. /Stanford U., Phys. Dept. /Bern U., LHEP /SLAC /Laurentian U. /SLAC /Maryland U.

    2011-12-02

    EXO-200 uses 468 large area avalanche photodiodes (LAAPDs) for detection of scintillation light in an ultra-low-background liquid xenon (LXe) detector. We describe initial measurements of dark noise, gain and response to xenon scintillation light of LAAPDs at temperatures from room temperature to 169 K - the temperature of liquid xenon. We also describe the individual characterization of more than 800 LAAPDs for selective installation in the EXO-200 detector.

  14. Microscopic MR imaging of cataracts at 200 MHz

    International Nuclear Information System (INIS)

    An MR microscope (gradient strength, up to 100 gauss/cm; diameter, 7 mm; typical resolution, 20-40 μm) operating at 200 MHz is used to study cataract formation in a rat cataract model. Factors determining image intensity at 200 MHz such as T1, T2, and diffusion are discussed. In particular, these gradient strengths are typical for pulsed gradient diffusion experiments. The authors compare image intensity with the cellular changes accompanying cataract formation

  15. The Lake Baikal Neutrino Telescope NT-200: Status, results, future

    International Nuclear Information System (INIS)

    The Baikal Neutrino Telescope NT-200 has been put into operation on April 6th, 1998. We describe the parameters and structure of NT-200 and present results with various stages of the stepwise increasing detector: from NT-36 to NT-96. Results cover atmospheric muons, neutrino events, search for neutrino events from WIMPS annihilation, search for magnetic monopoles. We also give preliminary results of the combined operation of the underwater array and a Cherenkov EAS array, placed on the ice surface

  16. Licensing of the construction permit of the NHR-200

    International Nuclear Information System (INIS)

    The nuclear heating reactor (NHR) was developed by the Institute of Nuclear Energy Technology (INET), Tsinghua University. The main design features and safety concepts of the NHR-200, the criteria and principles that were followed in licensing the construction permit of the NHR-200 are discussed. Licensing activities and procedures are described. Some of the main licensing safety issues including accident analysis, secondary containment design, the requirements for the Diesel generators and the safety classification of systems and components are briefly addressed

  17. Pleurodesis by erythromycin, tetracycline, Aerosil™ 200, and erythromycin plus Aerosil™ 200 in a rat model: a preliminary study

    OpenAIRE

    Hashemzadeh Shahryar; Hashemzadeh Khosrow; Mamaghani Kamran; Ansari Elnaz; Aligholipour Raheleh; EJ Golzari Samad; Ghabili Kamyar

    2012-01-01

    Abstract Background None of the current pleurodesing agents fulfil all the criteria for best pleural sclerosant. Therefore, the search for the ideal agent for chemical pleurodesis still continues. The aim of the present study was to compare the effectiveness of erythromycin, tetracycline, Aerosil™ 200 (hydrophilic fumed amorphous silica), and erythromycin plus Aerosil™ 200 in producing pleurodesis in rats. In the present study, talc was not used as a pleurodesing agent due to an unavailabilit...

  18. Pleurodesis by erythromycin, tetracycline, Aerosil™ 200, and erythromycin plus Aerosil™ 200 in a rat model: a preliminary study

    Directory of Open Access Journals (Sweden)

    Hashemzadeh Shahryar

    2012-11-01

    Full Text Available Abstract Background None of the current pleurodesing agents fulfil all the criteria for best pleural sclerosant. Therefore, the search for the ideal agent for chemical pleurodesis still continues. The aim of the present study was to compare the effectiveness of erythromycin, tetracycline, Aerosil™ 200 (hydrophilic fumed amorphous silica, and erythromycin plus Aerosil™ 200 in producing pleurodesis in rats. In the present study, talc was not used as a pleurodesing agent due to an unavailability of its sterile and pure form in Iran. Methods Overall, 75 adult male Spraque-Dawley rats were randomized to 5 treatment groups. Each group received an intrapleural injection via 5 Fr Silastic tubes of one of the following sterile agents: 35mg/kg erythromycin in 2 ml of saline, 35mg/kg tetracycline in 2 ml of saline, 35mg/kg Aerosil™ 200 in 2ml of saline, erythromycin (35mg/kg in 2 ml of saline plus Aerosil™ 200 (35mg/kg in 2 ml of saline, or 2 ml of saline as a control. The animals were euthanized and necropsied 30 days after injection. The pleurae were assessed for macroscopic and microscopic evidence of surrounding inflammation and fibrosis. Results The median macroscopic score in the Aerosil™ 200 group was significantly higher than that in the erythromycin group (P P P  Conclusion This study suggests that Aerosil™ 200 with or without erythromycin may be more potent pleurodesis agent than erythromycin and tetracycline.

  19. Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle.

    Directory of Open Access Journals (Sweden)

    Siddappa N Byrareddy

    Full Text Available Lectin-like molecules and their receptors are cell surface molecules that have been shown to play a role in either facilitating infection or serving as transporters of HIV/SIV in vivo. The role of these lectin-like molecules in the pathogenesis of HIV/SIV infection continues to be defined. In efforts to gain further insight on the potential role of these lectin-like molecules, our laboratory generated monoclonal antibodies (mAb against the human analogs of rhesus macaque CD200, CD200R and Mincle, since the rhesus macaques are accepted as the most reliable animal model to study human HIV infection. The characterization of the cell lineages from the blood and various tissues of rhesus macaques that express these lectin-like molecules are described herein. Among the mononuclear cells, the cells of the myeloid lineage of rhesus macaques are the predominant cell lineages that express readily detectable levels of CD200, CD200R and Mincle that is similar to the expression of Siglec-1 and Siglec-3 reported by our laboratory earlier. Subset analysis revealed that a higher frequency of the CD14+/CD16- subset from normal rhesus macaques express CD200, CD200R and Mincle. Differences in the frequencies and density of expression of these molecules by the gated population of CD14+ cells from various tissues are noted with PBMC and bone marrow expressing the highest and the mononuclear cells isolated from the colon and ileum expressing the lowest levels. While a significant frequency of pDCs and mDCs express Siglec-1/Siglec-3, a much lower frequency expresses CD200, CD200R and Mincle in PBMCs from rhesus macaques. The mAb against CD200 and CD200R but not Mincle appear to inhibit the infection of macrophage tropic SIV/SHIV in vitro. We conclude that these mAbs may have potential to be used as adjunctive therapeutic agents to control/inhibit SIV/HIV infection.

  20. Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle.

    Science.gov (United States)

    Byrareddy, Siddappa N; Little, Dawn; Mayne, Ann E; Villinger, Francois; Ansari, Aftab A

    2015-01-01

    Lectin-like molecules and their receptors are cell surface molecules that have been shown to play a role in either facilitating infection or serving as transporters of HIV/SIV in vivo. The role of these lectin-like molecules in the pathogenesis of HIV/SIV infection continues to be defined. In efforts to gain further insight on the potential role of these lectin-like molecules, our laboratory generated monoclonal antibodies (mAb) against the human analogs of rhesus macaque CD200, CD200R and Mincle, since the rhesus macaques are accepted as the most reliable animal model to study human HIV infection. The characterization of the cell lineages from the blood and various tissues of rhesus macaques that express these lectin-like molecules are described herein. Among the mononuclear cells, the cells of the myeloid lineage of rhesus macaques are the predominant cell lineages that express readily detectable levels of CD200, CD200R and Mincle that is similar to the expression of Siglec-1 and Siglec-3 reported by our laboratory earlier. Subset analysis revealed that a higher frequency of the CD14+/CD16- subset from normal rhesus macaques express CD200, CD200R and Mincle. Differences in the frequencies and density of expression of these molecules by the gated population of CD14+ cells from various tissues are noted with PBMC and bone marrow expressing the highest and the mononuclear cells isolated from the colon and ileum expressing the lowest levels. While a significant frequency of pDCs and mDCs express Siglec-1/Siglec-3, a much lower frequency expresses CD200, CD200R and Mincle in PBMCs from rhesus macaques. The mAb against CD200 and CD200R but not Mincle appear to inhibit the infection of macrophage tropic SIV/SHIV in vitro. We conclude that these mAbs may have potential to be used as adjunctive therapeutic agents to control/inhibit SIV/HIV infection. PMID:26468886

  1. 200 Area plateau inactive miscellaneous underground storage tanks locations

    International Nuclear Information System (INIS)

    Fluor Daniel Northwest (FDNW) has been tasked by Lockheed Martin Hanford Corporation (LMHC) to incorporate current location data for 64 of the 200-Area plateau inactive miscellaneous underground storage tanks (IMUST) into the centralized mapping computer database for the Hanford facilities. The IMUST coordinate locations and tank names for the tanks currently assigned to the Hanford Site contractors are listed in Appendix A. The IMUST are inactive tanks installed in underground vaults or buried directly in the ground within the 200-East and 200-West Areas of the Hanford Site. The tanks are categorized as tanks with a capacity of less than 190,000 liters (50,000 gal). Some of the IMUST have been stabilized, pumped dry, filled with grout, or may contain an inventory or radioactive and/or hazardous materials. The IMUST have been out of service for at least 12 years

  2. The EXO-200 detector, part I: Detector design and construction

    CERN Document Server

    Auger, M; Barbeau, P S; Bartoszek, L; Baussan, E; Beauchamp, E; Benitez-Medina, C; Breidenbach, M; Chauhan, D; Cleveland, B; Conley, R; Cook, J; Cook, S; Coppens, A; Craddock, W; Daniels, T; Davis, C G; Davis, J; deVoe, R; Dobi, A; Dolinski, M J; Dunford, M; Fairbank, W; Farine, J; Fierlinger, P; Franco, D; Giroux, G; Gornea, R; Graham, K; Gratta, G; Hagemann, C; Hall, C; Hall, K; Hargrove, C; Herrin, S; Hodgson, J; Hughes, M; Karelin, A; Kaufman, L J; Kirk, J; Kuchenkov, A; Kumar, K; Leonard, D S; Leonard, F; LePort, F; Mackay, D; MacLellan, R; Marino, M; Merkle, K; Mong, B; Díez, M Montero; Müller, A R; Neilson, R; Odian, A; O'Sullivan, K; Oullet, C; Piepke, A; Pocar, A; Prescott, C Y; Pushkin, K; Rivas, A; Rollin, E; Rowson, P C; Sabourov, A; Sinclair, D; Skarpaas, K; Slutsky, S; Stekhanov, V; Strickland, V; Swift, M; Tosi, D; Twelker, K; Vuilleumier, J -L; Vuilleumier, J -M; Walton, T; Weber, M; Wichoski, U; Wodin, J; Wright, J D; Yang, L; Yen, Y -R

    2012-01-01

    EXO-200 is an experiment designed to search for double beta decay of $^{136}$Xe with a single-phase, liquid xenon detector. It uses an active mass of 110 kg of xenon enriched to 80.6% in the isotope 136 in an ultra-low background time projection chamber capable of simultaneous detection of ionization and scintillation. This paper describes the EXO-200 detector with particular attention to the most innovative aspects of the design that revolves around the reduction of backgrounds, the efficient use of the expensive isotopically enriched xenon, and the optimization of the energy resolution in a relatively large volume.

  3. Generation and detection of ultrabroadband infrared wave exceeding 200 THz

    Directory of Open Access Journals (Sweden)

    Ashida Masaaki

    2013-03-01

    Full Text Available By focusing a hollow-fiber compressed intense 10–fs pulse and its second harmonic in air, an ultrabroadband infrared pulse with a spectral range of 1–200 THz is generated through a plasma. Coherent detection of the signal up to 100 THz is achieved with electro–optic sampling and THz air-breakdown-coherent-detection. The drastic dependence on the orientation of the second harmonic crystal is clarified in a range of 100–200 THz. From these, the whole frequency components are confirmed to be generated from the AC biased plasma and phase-locked.

  4. Plot-processing system in computer U-200, (1)

    International Nuclear Information System (INIS)

    In order to use terminal computer U-200 for plot-processing of experimental data, hardware and basic software have been prepared. The digital plotter, originally for system USC-3 can be used as an output device through the adapter consisting of decoding circuit and plot-driving pulse generator. Six subroutine subprograms were also prepared as basic software for U-200, which are called in FORTRAN langauge from the main routine of application programs: SUBROUTINE PLTSET, ... FACTOR, ... WHERE, ... PLOT, ... SYMBOL, and ... NUMBER. They are similar in functional structure to those for USC-3. (auth.)

  5. 200 West Groundwater Aggregate Area management study report

    International Nuclear Information System (INIS)

    This report presents the results of an aggregate area management study (AAMS) for the 200 West Groundwater Aggregate Area in the 200 Areas of the US Department of Energy (DOE) Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) or Resource Conservation and Recovery Act (RCRA), Facility Investigations (Rlq) and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment, storage or disposal (TSD) closure activities with CERCLA and RCRA past practice investigations

  6. 200 Area Liquid Effluent Facilities -- Quality assurance program plan

    International Nuclear Information System (INIS)

    This Quality Assurance Program Plan (QAPP) describes the quality assurance and management controls used by the 200 Area Liquid Effluent Facilities (LEF) to perform its activities in accordance with DOE Order 5700.6C. The 200 Area LEF consists of the following facilities: Effluent Treatment Facility (ETF); Treated Effluent Disposal Facility (TEDF); Liquid Effluent Retention facility (LERF); and Truck Loading Facility -- (Project W291). The intent is to ensure that all activities such as collection of effluents, treatment, concentration of secondary wastes, verification, sampling and disposal of treated effluents and solids related with the LEF operations, conform to established requirements

  7. 200 Areas soil remediation strategy -- Environmental Restoration Program

    International Nuclear Information System (INIS)

    The remediation and waste management activities in the 200 Areas of the Hanford Site (located in Richland, Washington) currently range from remediating groundwater, remediating source units (contaminated soils), decontaminating and decommissioning of buildings and structures, maintaining facilities, managing transuranic, low-level and mixed waste, and operating tank farms that store high-level waste. This strategy focuses on the assessment and remediation of soil that resulted from the discharge of liquids and solids from processing facilities to the ground (e.g., ponds, ditches, cribs, burial grounds) in the 200 Areas and addresses only those waste sites assigned to the Environmental Restoration Program

  8. 200-BP-5 operable unit Technical Baseline report

    Energy Technology Data Exchange (ETDEWEB)

    Jacques, I.D.; Kent, S.K.

    1991-10-01

    This report supports development of a remedial investigation/feasibility study work plan for the 200-BP-5 operable unit. The report summarizes baseline information for waste sites and unplanned release sites located in the 200-BP-5 operable unit. The sites were investigated by the Technical Baseline Section of the Environmental Engineering Group, Westinghouse Hanford Company (Westinghouse Hanford). The investigation consisted of review and evaluation of current and historical Hanford Site reports, drawings, and photographs, and was supplemented with recent inspections of the Hanford Site and employee interviews. No field investigations or sampling were conducted.

  9. 200-BP-5 operable unit Technical Baseline report

    International Nuclear Information System (INIS)

    This report supports development of a remedial investigation/feasibility study work plan for the 200-BP-5 operable unit. The report summarizes baseline information for waste sites and unplanned release sites located in the 200-BP-5 operable unit. The sites were investigated by the Technical Baseline Section of the Environmental Engineering Group, Westinghouse Hanford Company (Westinghouse Hanford). The investigation consisted of review and evaluation of current and historical Hanford Site reports, drawings, and photographs, and was supplemented with recent inspections of the Hanford Site and employee interviews. No field investigations or sampling were conducted

  10. 200 words you should use chambers address to impress

    CERN Document Server

    Watt, Donald

    2008-01-01

    A manageable way to improve your vocabulary: 200 words common enough to be generally understood, but difficult enough to be misused or neglectedEach term explained fully in everyday languageExamples from reputable sources showing how these words can be used to good effect Ever heard a word you wish you could use? Address to Impress clearly explains the meaning and nuance of 200 words selected by the editors of The Chambers Dictionary for their practical value. Quotes from popular media show each entry in context, and easily confusable words are flagged up to prevent

  11. Rhesus Rhadinovirus R15 Encodes a Functional Homologue of Human CD200

    OpenAIRE

    Langlais, Carly L.; Jones, John M.; Estep, Ryan D.; Wong, Scott W.

    2006-01-01

    A viral CD200 homologue (vCD200) encoded by open reading frame R15 of rhesus rhadinovirus (RRV), a gammaherpesvirus closely related to human herpesvirus 8 (HHV-8), is described here. RRV vCD200 shares 30% and 28% amino acid identity with human CD200 (huCD200) and HHV-8 vCD200, respectively. In vitro analysis indicated that an Fc fusion (vCD200-Fc) is expressed as a glycoprotein with a core molecular mass of 53 kDa. Utilizing monoclonal antibodies raised against vCD200-Fc, vCD200 expression wa...

  12. 24 CFR 200.926 - Minimum property standards for one and two family dwellings.

    Science.gov (United States)

    2010-04-01

    ... §§ 200.926a-200.926e, apply to single family detached homes, duplexes, three-unit homes, and to living... and two family dwellings. 200.926 Section 200.926 Housing and Urban Development Regulations Relating... Minimum Property Standards § 200.926 Minimum property standards for one and two family dwellings....

  13. 24 CFR 200.161 - Administration of debenture transactions.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Administration of debenture... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Mortgage Insurance Procedures and Processing Claims for Losses § 200.161 Administration of debenture transactions. The Secretary of...

  14. 17 CFR 200.610 - Self-evaluation.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Self-evaluation. 200.610...-evaluation. (a) The agency shall, by September 6, 1989, evaluate its current policies and practices, and the... handicaps or organizations representing individuals with handicaps, to participate in the...

  15. Measurement Technology on 200 Liters Barrels of Radioactive Waste

    Institute of Scientific and Technical Information of China (English)

    BAI; Lei; SHAO; Jie-wen; LIU; Da-ming; LIU; Hong-bin; CHENG; Yi-mei; HE; Li-xia; ZHU; Li-qun

    2012-01-01

    <正>The measurement device on 200 liters barrel of radioactive waste is designed following the rule of orderly measurement automatically, by using the technology of non-destructive to measure the mass of radioactive waste produced from fuel cycle. Device objects as shown in Fig. 1, which consists of the

  16. Photooxidation of dinitrophenylhistidine-200 human carbonic anhydrase B.

    Science.gov (United States)

    Kandel, M; Gornall, A G; Lam, L K; Kandel, S I

    1975-05-01

    Partial inactivation of tau-dinitrophenylhistidine-200 human carbonic anhydrase B, induced by visible light, followed first order kinetics (k(app) = 6.05 times 10-2 min-1). After 50 min the tau-dinitrophenylhistidine (tau-DNP-histidine) content decreased to a negligible level, but the illuminated enzyme retained, at pH 7.6, approximately 9.2 percent of the esterase activity of the native enzyme. The following lines of evidence suggest that the loss of activity results from the destruction of tau-DNP-histidine-200. (1) No significant loss of amino acid other than tau-DNP-histidine was detected after illumination. (2) The rate of loss of activity correlated well with the loss of tau-DNP-histidine. (3) In the photooxidized enzyme the DNP moiety was retained but had lost the characteristic sensitivity of tau-DNP-histidine to nucleophilic attack. Titration of the illuminated enzyme with acetazolamide indicated that the residual activity is an intrinsic property of the modified enzyme. The chromatographically purified photooxidized enzyme migrated as a single band on isoelectrofocusing in polyacylamide gel, and at pH 7.6 possessed 7.5 percent esterase activity relative to the native enzyme. By establishing effective destruction of histidine-200, it can be concluded that neither the pi N nor, as previously shown, the tau N of histidine-200 is critical for the catalysis. PMID:237619

  17. 24 CFR 200.36 - Financial reporting requirements.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Financial reporting requirements... Regulations § 200.36 Financial reporting requirements. The mortgagor must comply with the financial reporting requirements in 24 CFR part 5, subpart H....

  18. 34 CFR 200.36 - Communication with parents.

    Science.gov (United States)

    2010-07-01

    ... Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.36 Communication with parents. (a) Throughout the school improvement process, the State, LEA, or school must communicate with the parents of each child attending the school. (b) The State, LEA, or school must ensure...

  19. Analysis of Numerical Simulation Results of LIPS-200 Lifetime Experiments

    Science.gov (United States)

    Chen, Juanjuan; Zhang, Tianping; Geng, Hai; Jia, Yanhui; Meng, Wei; Wu, Xianming; Sun, Anbang

    2016-06-01

    Accelerator grid structural and electron backstreaming failures are the most important factors affecting the ion thruster's lifetime. During the thruster's operation, Charge Exchange Xenon (CEX) ions are generated from collisions between plasma and neutral atoms. Those CEX ions grid's barrel and wall frequently, which cause the failures of the grid system. In order to validate whether the 20 cm Lanzhou Ion Propulsion System (LIPS-200) satisfies China's communication satellite platform's application requirement for North-South Station Keeping (NSSK), this study analyzed the measured depth of the pit/groove on the accelerator grid's wall and aperture diameter's variation and estimated the operating lifetime of the ion thruster. Different from the previous method, in this paper, the experimental results after the 5500 h of accumulated operation of the LIPS-200 ion thruster are presented firstly. Then, based on these results, theoretical analysis and numerical calculations were firstly performed to predict the on-orbit lifetime of LIPS-200. The results obtained were more accurate to calculate the reliability and analyze the failure modes of the ion thruster. The results indicated that the predicted lifetime of LIPS-200's was about 13218.1 h which could satisfy the required lifetime requirement of 11000 h very well.

  20. 200 MeV RF linac for synchrotron injection

    International Nuclear Information System (INIS)

    Construction has been completed on an electron linear accelerator for the Brookhaven National Laboratory. This accelerator will be used for the injection of a 200 MeV electron beam into a synchrotron for lithography experiments. This paper describes the conceptual design of the linac, its e-gun pulser, and its control and timing systems. 3 figs., ref

  1. The positioning device of beam probes for accelerator LUE-200

    International Nuclear Information System (INIS)

    The description of a device for the positioning of sliding beam probes which is the part of the beam diagnostic system for the LUE-200 electron linac of IREN installation is presented. The device provides remote control of input-output operation of beam probes of five diagnostic stations established in an accelerating tract and in the beam transportation channel of the accelerator

  2. 24 CFR 200.75 - Environmental quality determinations and standards.

    Science.gov (United States)

    2010-04-01

    ... § 200.75 Environmental quality determinations and standards. Requirements set forth in 24 CFR part 50, Protection and Enhancement of Environmental Quality, 24 CFR part 51, Environmental Criteria and Standards, 24 CFR part 55, Implementation of Executive Order 11988, Flood Plain Management, and as...

  3. 20 CFR 401.200 - Blood donor locator service.

    Science.gov (United States)

    2010-04-01

    ... 401.200 Employees' Benefits SOCIAL SECURITY ADMINISTRATION PRIVACY AND DISCLOSURE OF OFFICIAL RECORDS... authority under State law relating to the public health or otherwise has the duty or authority under State... received pursuant to the rules in this part and section 1141 of the Social Security Act and related...

  4. 17 CFR 200.305 - Special procedure: Medical records.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Special procedure: Medical... Individuals and Systems of Records Maintained by the Commission § 200.305 Special procedure: Medical records... records pertaining to him that include medical and/or psychological information, the Commission, if...

  5. 17 CFR 200.735-4 - Outside employment and activities.

    Science.gov (United States)

    2010-04-01

    ... receipt of honoraria is discouraged (See 17 CFR 200.735-4(b)(7)), that rule is not applicable to the... by section 401(a) of Executive Order 11222, they are prohibited by Civil Service Regulations (5 CFR... reimbursement may be accepted for the travel expenses of an employee's spouse or traveling companion unless...

  6. 34 CFR 200.51 - Notice of SEA action.

    Science.gov (United States)

    2010-07-01

    ...) To the extent practicable, in a language that parents can understand. (2) The SEA must provide... community the results of its review under § 200.50, including statistically sound disaggregated results in..., including alternative formats upon request; and (ii) To the extent practicable, in a language that...

  7. 19 CFR 200.735-105 - Gifts, entertainment, and favors.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Gifts, entertainment, and favors. 200.735-105...-105 Gifts, entertainment, and favors. (a) Except as provided in paragraph (b) of this section, no employee may solicit or accept, directly or indirectly, any gift, gratuity, favor, entertainment, loan,...

  8. 34 CFR 200.53 - LEA corrective action.

    Science.gov (United States)

    2010-07-01

    ... SEA to identify an LEA for corrective action; and (ii) Any underlying staffing, curriculum, or other... programmatic funds or reduce administrative funds. (ii) Institute and fully implement a new curriculum based on... school consistent with § 200.44(h). (Approved by the Office of Management and Budget under control...

  9. Fission barrier heights in the A ∼ 200 mass region

    Indian Academy of Sciences (India)

    K Mahata

    2015-08-01

    Statistical model analysis is carried out for - and -induced fission reactions using a consistent description for fission barrier and level density in A ∼ 200 mass region. A continuous damping of shell correction with excitation energy is considered. Extracted fission barriers agree well with the recent microscopic–macroscopic model. The shell corrections at the saddle point were found to be insignificant.

  10. 17 CFR 200.23a - Office of Economic Analysis.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Office of Economic Analysis... Organization § 200.23a Office of Economic Analysis. The Office of Economic Analysis is responsible for... Office also assists the Commission's enforcement effort by applying economic analysis and...

  11. 36 CFR 200.7 - Request for records.

    Science.gov (United States)

    2010-07-01

    ... addresses listed in § 200.2; the Director of Law Enforcement and Investigations, other Staff Directors, or... processing of those records are governed by the rules at 7 CFR 1.6. Agency officials are authorized to...: (1) Extend the 10-day administrative deadline for reply pursuant to 7 CFR 1.14; (2)...

  12. Comparative Validity of the Shedler and Westen Assessment Procedure-200

    Science.gov (United States)

    Mullins-Sweatt, Stephanie N.; Widiger, Thomas A.

    2008-01-01

    A predominant dimensional model of general personality structure is the five-factor model (FFM). Quite a number of alternative instruments have been developed to assess the domains of the FFM. The current study compares the validity of 2 alternative versions of the Shedler and Westen Assessment Procedure (SWAP-200) FFM scales, 1 that was developed…

  13. Nanosecond iodine laser with an output energy of 200 J

    Energy Technology Data Exchange (ETDEWEB)

    Katulin, V.A.; Nosach, V.Y.; Petrov, A.L.

    1976-08-01

    A description is given of an iodine photodissociation laser with an output energy of 200 J in the form of pulses of 1 nsec duration and approx.2 x 10/sup -4/ rad divergence. The final amplifying stages are pumped with ultraviolet radiation produced by a high-current discharge in the working gas. (AIP)

  14. High efficiency 200 TEU container ship developed by CSC

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ After three years operation, the large, energy-efficient, environment-friendly 200 TEU container ship Changjiang developed by China Changjiang National Shipping Group Corporation (CSC) has become an important force in the fleet of container ships in the upper reaches of the Yangtze River in China.

  15. 24 CFR 200.162 - Certificates of claim.

    Science.gov (United States)

    2010-04-01

    ... Claims for Losses § 200.162 Certificates of claim. The certificate of claim issued to the mortgagee at... its investment in a particular property any excess over and above such investment is available for payment on the certificate of claim. Certificates of claim bear interest at the rate of 3 percent...

  16. 24 CFR 990.200 - Determination of formula amount.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Determination of formula amount... Subsidy § 990.200 Determination of formula amount. (a) General. The amount of operating subsidy that a PHA is eligible for is the difference between its formula expenses (as calculated under subpart C of...

  17. 19 CFR 200.735-125 - Exemption from restrictions.

    Science.gov (United States)

    2010-04-01

    ... any court, board, commission, or legislative body with respect to matters of fact within the personal... employee's testimony is required in the interest of justice. (2) Statements under penalty of perjury. A... 200.735-125 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION EMPLOYEE RESPONSIBILITIES...

  18. Russia to invest 200 million Swiss Francs in international accelerator

    CERN Multimedia

    2001-01-01

    Russia will invest 200 million CHF in the LHC project, according to first deputy industry, science and technologies minister. The results of scientific research in the center will be use in various industries, enabling new Russian technologies to enter the world market.

  19. 48 CFR 915.200 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... CONTRACT TYPES CONTRACTING BY NEGOTIATION Solicitation and Receipt of Proposals and Information 915.200 Scope of subpart. The 48 CFR subpart 15.2 is not applicable to Program Opportunity Notices for Commercial Demonstrations (See subpart 917.72) or Program Research and Development Announcements (See...

  20. 24 CFR 200.625 - Affirmative fair housing marketing plan.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.625 Affirmative fair housing marketing plan. Each applicant for participation in FHA housing... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Affirmative fair housing...

  1. 34 CFR 200.55 - Qualifications of teachers.

    Science.gov (United States)

    2010-07-01

    ... meet the requirements in § 200.56. (c) Definition. The term “core academic subjects” means English, reading or language arts, mathematics, science, foreign languages, civics and government, economics, arts... ensure that all teachers hired after the first day of the 2002-2003 school year who teach core...

  2. 41 CFR 109-50.200 - Scope of subpart.

    Science.gov (United States)

    2010-07-01

    ... related and Federal research equipment to elementary and secondary educational institutions or nonprofit organizations for the purpose of improving math and science curricula or conducting of technical and scientific... 50-SPECIAL DOE DISPOSAL AUTHORITIES 50.2-Math and Science Equipment Gift Program § 109-50.200...

  3. 17 CFR 200.735-5 - Securities transactions.

    Science.gov (United States)

    2010-04-01

    ... disqualification, such as those resulting from the automatic reinvestment of dividends, stock splits, stock... disqualification provisions of Rule 6, 17 CFR 200.735-6, and 18 U.S.C. 208 are applicable. (ii) For purposes of... 1940 (15 U.S.C. 80a-2(a)(37)) which become effective pursuant to 17 CFR 230.485(b). (2) Securities of...

  4. 48 CFR 50.200 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... EXTRAORDINARY CONTRACTUAL ACTIONS AND THE SAFETY ACT Support Anti-terrorism by Fostering Effective Technologies Act of 2002 50.200 Scope of subpart. This subpart implements the Support Anti-terrorism by Fostering Effective Technologies Act of 2002 (SAFETY Act) liability protections to promote development and use of...

  5. 40 CFR 180.200 - Dicloran; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Dicloran; tolerances for residues. 180... PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.200 Dicloran; tolerances for residues. (a) General. (1) Tolerances are established for residues of...

  6. CCNA routing and switching review guide exams 100-101, 200-101, and 200-120

    CERN Document Server

    Lammle, Todd

    2013-01-01

    Todd Lammle's focused, concise review guide, updated for the latest CCNA exams CCNA is one of the most sought after certifications for IT professionals. If you're preparing for the CCNA Routing and Switching certification, this Sybex review guide offers the best quick review available. Organized by exam objective, it's the perfect supplement to other learning tools, including the Sybex CCNA Routing and Switching Study Guide (ISBN: 9781118749616). All exam topics from exams 100-101, 200-101, and 200-120 are thoroughly covered, and additional study materials including bonus exams, electronic f

  7. CCNA routing and switching study guide exams 100-101, 200-101, and 200-120

    CERN Document Server

    Lammle, Todd

    2013-01-01

    Prepare for the new CCNA exams with this Todd Lammle study guide Cisco author, speaker, and trainer Todd Lammle is considered the authority on all things networking, and his books have sold almost a million copies worldwide. This all-purpose CCNA study guide methodically covers all the objectives of the ICND1 (100-101) and ICND2 (200-101) exams as well as providing additional insight for those taking CCNA Composite (200-120) exam. It thoroughly examines operation of IP data networks, LAN switching technologies, IP addressing (IPv4/IPv6), IP routing technologies, IP services, network device s

  8. Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle

    OpenAIRE

    Byrareddy, Siddappa N.; Little, Dawn; Mayne, Ann E.; Villinger, Francois; Aftab A. Ansari

    2015-01-01

    Lectin-like molecules and their receptors are cell surface molecules that have been shown to play a role in either facilitating infection or serving as transporters of HIV/SIV in vivo. The role of these lectin-like molecules in the pathogenesis of HIV/SIV infection continues to be defined. In efforts to gain further insight on the potential role of these lectin-like molecules, our laboratory generated monoclonal antibodies (mAb) against the human analogs of rhesus macaque CD200, CD200R and Mi...

  9. Introducing HiggsBounds 2.0.0

    Energy Technology Data Exchange (ETDEWEB)

    Bechtle, Philip; Weiglein, Georg [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Brein, Oliver [Freiburg Univ. (Germany). Physikalisches Inst.; Heinemeyer, Sven [Instituto de Fisica de Cantabria (CSIC-UC), Santander (Spain); Williams, Karina [Bonn Univ. (Germany). Bethe Center for Theoretical Physics

    2011-01-15

    We introduce version 2.0.0 of the computer program HiggsBounds. The program tests neutral and charged Higgs sectors of arbitrary models against the current exclusion bounds from LEP and the Tevatron. As input, it requires a selection of model predictions, such as Higgs masses, branching ratios, effective couplings and total decay widths. The program uses the expected and observed topological cross section limits from the Higgs searches to determine whether a given parameter scenario of a model is excluded at the 95% C.L. by those searches. Version 2.0.0 includes 39/53 LEP/Tevatron Higgs search analyses, compared to 13/36 in the previous release (1.2.0). Among the newly included analyses are LEP searches for neutral Higgs bosons (H) decaying invisibly or into hadrons, LEP searches via the production modes {tau}{sup +}{tau}{sup -}H and b anti bH, Tevatron searches via t anti tH, and LEP and Tevatron searches for charged Higgs bosons. Also, all Tevatron results presented at the ICHEP'10 are included in version 2.0.0. In this note, we explain the basic ideas behind the implementation of HiggsBounds and provide a list of search topologies implemented in version 2.0.0. Furthermore, we apply HiggsBounds 2.0.0 to (a) determine the allowed Higgs mass range for a simple 4th generation model, (b) update/reproduce LEP/Tevatron Higgs exclusion plots for the MSSM m{sub h}{sup max} benchmark scenario, and (c) show exclusion results for the scalar sector of the Randall-Sundrum model. (orig.)

  10. Pathogenicity of Autoantibodies in Anti-p200 Pemphigoid

    Science.gov (United States)

    Beckmann, Tina; Hirose, Misa; Dworschak, Jenny; Recke, Andreas; Ludwig, Ralf J.; Hashimoto, Takashi; Zillikens, Detlef; Schmidt, Enno

    2012-01-01

    Recently, the C-terminus of laminin γ1 has been identified as target antigen in anti-p200 pemphigoid and the disease was renamed as anti-laminin γ1 pemphigoid. However, the pathogenic relevance of these autoantibodies has not yet been demonstrated. Therefore, we employed an ex vivo model of autoantibody-mediated leukocyte-dependent neutrophil activation and dermal-epidermal separation (DES) using cryosections of human skin. We showed that anti-p200 pemphigoid sera (n = 7) induced DES in a time-dependent manner, in contrast to sera from healthy controls. Furthermore, laminin γ1-specific IgG and serum depleted from anti-laminin γ1 reactivity were generated using the recombinant C-terminus of laminin γ1 (LAMC1-term; amino acids 1364 to 1609). Interestingly, both fractions labeled the dermal-epidermal-junction (DEJ) by indirect immunofluorescence microscopy on human foreskin and recognized a 200 kDa protein by immunoblotting with dermal extract. Human and rabbit IgG against LAMC1-cterm failed to attract neutrophils at the DEJ and to induce DES. In contrast, patient serum depleted from LAMC1-cterm reactivity led to the same extent of DES as non-depleted IgG. Repeated injection of rabbit anti-murine LAMC1-cterm IgG into both neonatal and adult C57BL/6mice as well as repetitive immunization of various mouse strains with murine LAMC1-cterm failed to induce macro- and microscopic lesions. In all mice, circulating anti-LAMC1-cterm antibodies were present, but only in some mice, IgG deposits were seen at the DEJ. We conclude that autoantibodies in anti-p200 pemphigoid sera are pathogenic while pathogenicity is not mediated by autoantibodies against laminin γ1. Further studies are needed to identify the pathogenically relevant autoantigen in anti-p200 pemphigoid. PMID:22911854

  11. Feasibility study report for the 200-BP-1 operable unit

    International Nuclear Information System (INIS)

    This feasibility study examines a range of alternatives and provides recommendations for selecting a preferred alternative for remediating contamination at the 200-BP-1 operable unit. The 200-BP-1 operable unit is located in the center of the Hanford Site along the northern boundary of the 200 East Area. The 241-BY Tank Farm is located immediately to the south of the operable unit. 200-BP-1 is a source operable unit with contaminated soils associated primarily with nine inactive cribs (known as the 216-B cribs). These cribs were used for disposal of low-level radioactive liquid waste from U Plant uranium recovery operations, and waste storage tank condensate from the adjacent 241-BY Tank Farm. The cribs used for disposal of U Plant waste were in operation from 1955--1965, and the cribs used for disposal of tank condensate were in operation from 1965--1975. In addition to the cribs, four unplanned releases of radioactive materials have occurred within the operable unit. Contaminated surface soils associated with the unplanned releases have been consolidated over the cribs and covered with clean soil to reduce contaminant migration and exposure. Discharge of wastes to the cribs has resulted in soil and groundwater contamination. The groundwater is being addressed as part of the 200 East Aggregate Area, groundwater operable unit. Contaminated soils at the site can be categorized by the types of contaminants, their distribution in the soil column, and the risk posed by the various potential exposure pathways. Below the clean soil cover, the near surface soils contain low-levels of contamination with cesium-137, radium-226, strontium-90, thorium-228, and uranium. The lifetime incremental cancer risk associated with these soils if they were exposed at the surface is 9x10-5

  12. Feasibility study report for the 200-BP-1 operable unit

    International Nuclear Information System (INIS)

    This feasibility study (FS) examines a range of alternatives and provides recommendations for selecting a preferred altemative for remediating contamination at the 200-BP-1 operable unit. The 200-BP-1 operable unit is located in the center of the Hanford Site along the northern boundary of the 200 East Area. The 241-BY Tank Farm is located immediately to the south of the operable unit. 200-BP-1 is a source operable unit with contaminated soils associated primarily with nine inactive cribs (known as the 216-B cribs). These cribs were used for disposal of low-level radioactive liquid waste from U Plant uranium recovery operations, and waste storage tank condensate from the adjacent 241-BY Tank Farm. The cribs used for disposal of U Plant waste were in operation from 1955--1965, and the cribs used for disposal of tank condensate were in operation from 1965-1975. In addition to the cribs, four unplanned releases of radioactive materials have occurred within the operable unit. Contaminated surface soils associated with the unplanned releases have been consolidated over the cribs and covered with clean soil to reduce contaminant migration and exposure. Discharge of wastes to the cribs has resulted in soil and groundwater contamination. The groundwater is being addressed as part of the 200 East Aggregate Area groundwater operable unit. Contaminated soils at the site can be categorized by the types of contaminants, their distribution in the soil column, and the risk posed by the various potential exposure pathways. Below the clean soil cover, the near surface soils contain low-:levels of contamination with cesium-137, radium-226, strontium-90, thorium-228 and uranium. The lifetime incremental cancer risk associated with these soils if they were exposed at the surface is 9 x 105

  13. Pathogenicity of autoantibodies in anti-p200 pemphigoid.

    Directory of Open Access Journals (Sweden)

    Katerina Vafia

    Full Text Available Recently, the C-terminus of laminin γ1 has been identified as target antigen in anti-p200 pemphigoid and the disease was renamed as anti-laminin γ1 pemphigoid. However, the pathogenic relevance of these autoantibodies has not yet been demonstrated. Therefore, we employed an ex vivo model of autoantibody-mediated leukocyte-dependent neutrophil activation and dermal-epidermal separation (DES using cryosections of human skin. We showed that anti-p200 pemphigoid sera (n = 7 induced DES in a time-dependent manner, in contrast to sera from healthy controls. Furthermore, laminin γ1-specific IgG and serum depleted from anti-laminin γ1 reactivity were generated using the recombinant C-terminus of laminin γ1 (LAMC1-term; amino acids 1364 to 1609. Interestingly, both fractions labeled the dermal-epidermal-junction (DEJ by indirect immunofluorescence microscopy on human foreskin and recognized a 200 kDa protein by immunoblotting with dermal extract. Human and rabbit IgG against LAMC1-cterm failed to attract neutrophils at the DEJ and to induce DES. In contrast, patient serum depleted from LAMC1-cterm reactivity led to the same extent of DES as non-depleted IgG. Repeated injection of rabbit anti-murine LAMC1-cterm IgG into both neonatal and adult C57BL/6mice as well as repetitive immunization of various mouse strains with murine LAMC1-cterm failed to induce macro- and microscopic lesions. In all mice, circulating anti-LAMC1-cterm antibodies were present, but only in some mice, IgG deposits were seen at the DEJ. We conclude that autoantibodies in anti-p200 pemphigoid sera are pathogenic while pathogenicity is not mediated by autoantibodies against laminin γ1. Further studies are needed to identify the pathogenically relevant autoantigen in anti-p200 pemphigoid.

  14. Environmental assessment for the salvage/demolition of 200 West Area, 200 East Area, and 300 Area steam plants

    International Nuclear Information System (INIS)

    This environmental assessment has been prepared to assess potential environmental impacts associated with the US Department of Energy's proposed action: the salvage/demolition of the 200 West Area, 200 East Area, and 300 Area Steam Plants and steam distribution piping. Impact information will be used by the US Department of Energy, Richland Operations Office Manager, to determine if the proposed action is a major federal action significantly affecting the quality of the human environment. If the proposed action is determined to be major and significant, an environmental impact statement will be prepared. If the proposed action is determined not to be major and significant, a Finding of No Significant Impact (FONSI) will be issued and the action can proceed. The proposed action involves the salvage and demolition of the 200 West Area, 200 East Are, and 300 Area steam plants and their associated steam distribution piping, equipment, and ancillary facilities. Activities include the salvaging and recycling of all materials, wastes, and equipment where feasible, with waste minimization efforts utilized

  15. Eddy current characterization of magnetic treatment of nickel 200

    Science.gov (United States)

    Chern, E. J.

    1993-01-01

    Eddy current methods have been applied to characterize the effect of magnetic treatments on component service-life extension. Coil impedance measurements were acquired and analyzed on nickel 200 specimens that have been subjected to many mechanical and magnetic engineering processes: annealing, applied strain, magnetic field, shot peening, and magnetic field after peening. Experimental results have demonstrated a functional relationship between coil impedance, resistance and reactance, and specimens subjected to various engineering processes. It has shown that magnetic treatment does induce changes in electromagnetic properties of nickel 200 that then exhibit evidence of stress relief. However, further fundamental studies are necessary for a thorough understanding of the exact mechanism of the magnetic field processing effect on machine-tool service life.

  16. Fact Sheet for KM200 Front-end Electronics

    Energy Technology Data Exchange (ETDEWEB)

    Ianakiev, Kiril Dimitrov [Los Alamos National Laboratory; Iliev, Metodi [Los Alamos National Laboratory; Swinhoe, Martyn Thomas [Los Alamos National Laboratory

    2015-07-08

    The KM200 device is a versatile, configurable front-end electronics boards that can be used as a functional replacement for Canberra’s JAB-01 boards based on the Amptek A-111 hybrid chip, which continues to be the preferred choice of electronics for large number of the boards in junction boxes of multiplicity counters that process the signal from an array of 3He detectors. Unlike the A-111 chip’s fixed time constants and sensitivity range, the shaping time and sensitivity of the new KM200 can be optimized for demanding applications such as spent fuel, and thus could improve the safeguards measurements of existing systems where the A-111 or PDT electronics does not perform well.

  17. Upgrade of the Brookhaven 200 MeV linac

    International Nuclear Information System (INIS)

    The Brookhaven 200 MeV linac serves as the injector for the AGS Booster, as well as delivering beam to the Biomedical Isotope Resource Center. During the past year, many linac systems have been upgraded to allow operation at 2.5 times higher average current (150 μA). This was achieved by an increase in rep-rate from 5 to 7.5 Hz, an increase in beam current from 25 mA to 37 mA, and a slight increase in pulse width to ∼530 μs. Additional upgrades were made to improve reliability and modernize old systems. This paper describes improvements made in the 35 keV and 750 keV beam transport, 200 MeV beam transport, rf transmission line, rf power supplies, control systems, and instrumentation

  18. Fire Hazards Analysis for the 200 Area Interim Storage Area

    International Nuclear Information System (INIS)

    This documents the Fire Hazards Analysis (FHA) for the 200 Area Interim Storage Area. The Interim Storage Cask, Rad-Vault, and NAC-1 Cask are analyzed for fire hazards and the 200 Area Interim Storage Area is assessed according to HNF-PRO-350 and the objectives of DOE Order 5480 7A. This FHA addresses the potential fire hazards associated with the Interim Storage Area (ISA) facility in accordance with the requirements of DOE Order 5480 7A. It is intended to assess the risk from fire to ensure there are no undue fire hazards to site personnel and the public and to ensure property damage potential from fire is within acceptable limits. This FHA will be in the form of a graded approach commensurate with the complexity of the structure or area and the associated fire hazards

  19. Colloid formation during the corrosion of SRL 200 glass

    International Nuclear Information System (INIS)

    Nonradioactive SRL 200S glass and fully radioactive SRL 200R glass were reacted at glass surface areas to leachant volume (SA/V) ratios of 20,000, 2,000, and 340 m-1 for times varying from several days to a few years. The particles present in the leachates of these tests have been examined by analytical electron microscopy (AEM). The major colloidal clay phase was identified as a smectite clay from its characteristic electron diffraction pattern. The clay colloids eventually disappear from the solution and return to the glass; the time at which this occurs depends on the SA/V. Uranium silicate particles and calcium-bearing phases were also sometimes found in the leachates

  20. Raman spectroscopy of hot hydrogen above 200 GPa

    Science.gov (United States)

    Howie, Ross T.; Dalladay-Simpson, Philip; Gregoryanz, Eugene

    2015-05-01

    It has been theorized that at high pressure the increased energy of the zero-point oscillations in hydrogen would destabilize the lattice and form a ground fluid state at 0 K (ref. ). Theory has also suggested that this fluid state, representing a new state of matter, might have unusual properties governed by quantum effects, such as superfluidity or superconductivity. Here, by combining Raman spectroscopy and in situ high-temperature, high-pressure techniques, we demonstrate that above 200 GPa a new phase transition occurs as temperature is increased, for example 480 K at 255 GPa. If the transformation is interpreted as melting, it would be the lowest melting temperature of any material at these high pressures. We also find a new triple point between phases I and IV and the new phase, and demonstrate that hydrogen retains its molecular character around this point. These data may require a significant revision of the phase diagram of hydrogen above 200 GPa.

  1. Continuing the Operation of EXO-200 at WIPP

    Energy Technology Data Exchange (ETDEWEB)

    Gratta, Giorgio [Stanford Univ., CA (United States)

    2016-02-24

    This grant supported, in part, the operations of the EXO-200 double beta decay experiment at the Waste Isolation Pilot Plant (WIPP) for the period May 1, 2013 to Sept 30, 2015. In this period EXO-200 completed its first phase of data taking, although its operation was disrupted in Feb 2014 by the accidents at WIPP (unrelated to the experiment). The primary goal of the experiment is to search for the very rate (and to date not observed) neutrino-less double beta decay. Such decay, if observed, would shed the light of the quantum-mechanical structure of neutrinos, and the origins of elementary particle masses. Another goal of the detector is to serve as prototype of a larger neutrino-less double beta decay experiment, currently being considered by DOE-OS.

  2. Stabilization of 200-atom platinum nanoparticles by organosilane fragments

    KAUST Repository

    Pelzer, Katrin

    2011-04-19

    Three\\'s a charm: Platinum nanoparticles of 2 nm diameter and containing approximately 200 atoms covered with n-octylsilyl groups (see picture, right; Pt blue, Si red, C gray, H turquoise) form when [Pt(dba)2] (dba=dibenzylideneacetone) decomposes in the presence of n-octylsilane. The particles adopt a cuboctahedral structure with an edge length of three atoms. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Condensation pool experiments with steam using DN200 blowdown pipe

    International Nuclear Information System (INIS)

    This report summarizes the results of the condensation pool experiments with steam using a DN200 blowdown pipe. Altogether five experiment series, each consisting of several steam blows, were carried out in December 2004 with a scaled-down test facility designed and constructed at Lappeenranta University of Technology. The main purpose of the experiments was to increase the understanding of different phenomena in the condensation pool during steam discharge. (au)

  4. Fission fragment mass distributions in reactions populating 200Pb

    CERN Document Server

    Chaudhuri, A; Ghosh, T K; Banerjee, K; Sadhukhan, Jhilam; Bhattacharya, S; Roy, P; Roy, T; Bhattacharya, C; Asgar, Md A; Dey, A; Kundu, S; Manna, S; Meena, J K; Mukherjee, G; Pandey, R; Rana, T K; Srivastava, V; Dubey, R; Kaur, Gurpreet; Saneesh, N; Sugathan, P; Bhattacharya, P

    2016-01-01

    The fission fragment mass distributions have been measured in the reactions 16O + 184W and 19F+ 181Ta populating the same compound nucleus 200Pb? at similar excitation energies. It is found that the widths of the mass distribution increases monotonically with excitation energy, indicating the absence of quasi-fission for both reactions. This is contrary to two recent claims of the presence of quasi-fission in the above mentioned reactions.

  5. Condensation pool experiments with steam using DN200 blowdown pipe

    Energy Technology Data Exchange (ETDEWEB)

    Laine, J.; Puustinen, M. [Lappeenranta Univ. of Technology (Finland)

    2005-08-01

    This report summarizes the results of the condensation pool experiments with steam using a DN200 blowdown pipe. Altogether five experiment series, each consisting of several steam blows, were carried out in December 2004 with a scaled-down test facility designed and constructed at Lappeenranta University of Technology. The main purpose of the experiments was to increase the understanding of different phenomena in the condensation pool during steam discharge. (au)

  6. Hydrogen Plasma Generation with 200 MHz RF Ion Source

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeongtae; Park, Kwangmook; Seo, Dong Hyuk; Kim, Han-Sung; Kwon, Hyeok-Jung; Cho, Yong-Sub [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    The ion source for the system is required to be rugged with 2000 hours maintenance free operation time because it is installed in the vessel filled with SF6 gas at the pressure of 10 bar. A 200 MHz RF ion source is considered as an ion source. It is a simple construction and provides long life operation. The specifications of the ion source are 5 kV extraction voltage and 1 mA beam current referenced to the proton. RF ion source has been developed and undergone a performance test. Results of the test are presented. 200 MHz RF ion source is designated and manufactured. First of all test stand test of ion source are set up for a performance test of ion source. It includes a RF ion source, a 200-MHz RF system, beam extraction system, vacuum system, beam extraction system, and beam diagnostic system. At pressure of 1.2E-5 torr, hydrogen plasma is generated with net RF power 70 W. Pyrex tube surrounded by an inductive coil takes the role of vessel and discharge is enhanced with field of permanent magnets.

  7. The New IJS MR200 TLD Measuring System

    International Nuclear Information System (INIS)

    Measuring system for thermoluminescent dosimetry MR200 was developed at Jozef Stefan Institute in the 80s. The system has been successfully used for almost 20 years in personal and environmental dosimetry, together with the CaF2:Mn dosimeters, also produced at our institute. New standards in radiation protection dosimetry, as well as recent development of personal computers, were the main reasons to initiate the project of upgrading the system and testing its characteristics for compliance with the IEC international electrotechnical standards. The measuring system is based on the analog part of the TL reader MR200, which remained unchanged. The main elements of the analog part are: the electrically heated oven in nitrogen atmosphere with welded thermocouple, and the optical part with the photo multiplier and the reference light source. The new measuring system is fully PC controlled in the Windows environment. The upgraded MR200 TLD thermoluminescent system preserved all the good measuring properties of the original design. With the new process control many advantages were acquired, making it more user friendly and suitable for routine, as well as research applications. The system complies with the IEC1066 standard for environmental dosimetry. Measuring capabilities can easily be adapted to future demands by means of software changes. One example of future development is adjusting the measuring procedure also for personal dosimetry with use of energy compensated CaF2:Mn. (author)

  8. 75 FR 61985 - Airworthiness Directives; Boeing Model 747-100, 747-100B, 747-100B SUD, 747-200B, 747-200F, 747...

    Science.gov (United States)

    2010-10-07

    ... 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034...-100, 747-100B, 747- 100B SUD, 747-200B, 747-200F, 747-300, 747-400, 747-400D, 747SP, and 747SR Series... 747-100, 747-100B, 747-100B SUD, 747-200B, 747-200F, 747-300, 747-400, 747-400D, 747SP, and...

  9. The JHP 200-MeV proton linear accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Takao [National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan)

    1997-11-01

    A 200-MeV proton linear accelerator for the Japanese Hadron Project (JHP) has been designed. It consists of a 3-MeV radio-frequency quadrupole linac (RFQ), a 50-MeV drift tube linac (DTL) and a 200-MeV separated-type drift tube linac (SDTL). A frequency of 324 MHz has been chosen for all of the rf structures. A peak current of 30 mA (H{sup -} ions) of 400 {mu}sec pulse duration will be accelerated at a repetition rate of 25 Hz. A future upgrade plan up to 400 MeV is also presented, in which annular-coupled structures (ACS) of 972 MHz are used in an energy range of above 150 or 200 MeV. One of the design features is its high performance for a beam-loss problem during acceleration. It can be achieved by separating the transition point in the transverse motion from that of the longitudinal motion. The transverse transition at a rather low-energy range decreases the effects of space-charge, while the longitudinal transition at a rather high-energy range decreases the effects of nonlinear problems related to acceleration in the ACS. Coupled envelope equations and equipartitioning theory are used for the focusing design. The adoption of the SDTL structure improves both the effective shunt impedance and difficulties in fabricating drift tubes with focusing magnets. An accurate beam-simulation code on a parallel supercomputer was used for confirming any beam-loss problem during acceleration. (author)

  10. Hydrogeology of the 200 Areas low-level burial grounds

    International Nuclear Information System (INIS)

    This report presents information derived form the installation of 35 ground-water monitoring wells around six low-level radioactive/hazardous waste burial grounds located in the 200 Areas of the Hanford Site in southeastern Washington State. This information was collected between May 20, 1987 and August 1, 1988. The contents of this report have been divided into two volumes. Volume 1 contains the main text. This Volume contains the appendixes, including data and supporting information that verify content and results found in the main text

  11. POLYSHIFT Communications Software for the Connection Machine System CM-200

    Directory of Open Access Journals (Sweden)

    William George

    1994-01-01

    Full Text Available We describe the use and implementation of a polyshift function PSHIFT for circular shifts and end-offs shifts. Polyshift is useful in many scientific codes using regular grids, such as finite difference codes in several dimensions, and multigrid codes, molecular dynamics computations, and in lattice gauge physics computations, such as quantum chromodynamics (QCD calculations. Our implementation of the PSHIFT function on the Connection Machine systems CM-2 and CM-200 offers a speedup of up to a factor of 3–4 compared with CSHIFT when the local data motion within a node is small. The PSHIFT routine is included in the Connection Machine Scientific Software Library (CMSSL.

  12. The 200 l stainless steel canister - remote handling clutch assembly

    International Nuclear Information System (INIS)

    The assembly 200 l stainless steel canister with remote handling clutch is an equipment for conditioning, transport and intermediate storage of solid low- and intermediate level radioactive wastes. Loading the canister with pre-conditioned radioactive wastes is done at Post-Irradiation Examination Laboratory (LEPI) of INR Pitesti either within the transfer cell (CT) or supra-cell (SC). To this goal, lifting and handling means with which the LEPI is equipped, namely, lifting bridge and remote handling clutch are used. Conditioning of waste in view of their removal from LEPI implies their solidification in concrete and placing in stainless steel canister, the operations being effected in adequate rooms correspondingly equipped in the frame of the shop located at +8.40 m height at LEPI. Technical characteristics are: - capacity, 200 l; - external diameter, max. 600 mm; - casing height, 925 mm; casing thickness, 1.5 mm; - bottom thickness, 3 mm; - lid thickness, 3 mm. The canister cross profile of the lower and upper ends is modelled so that pilling is possible without horizontal slipping. The equipment together with remote handling clutch, engaged in a special collar of the upper part of canister, is presented

  13. Safety analysis, 200 Area, Savannah River Plant: Separations area operations

    Energy Technology Data Exchange (ETDEWEB)

    Perkins, W.C.; Lee, R.; Allen, P.M.; Gouge, A.P.

    1991-07-01

    The nev HB-Line, located on the fifth and sixth levels of Building 221-H, is designed to replace the aging existing HB-Line production facility. The nev HB-Line consists of three separate facilities: the Scrap Recovery Facility, the Neptunium Oxide Facility, and the Plutonium Oxide Facility. There are three separate safety analyses for the nev HB-Line, one for each of the three facilities. These are issued as supplements to the 200-Area Safety Analysis (DPSTSA-200-10). These supplements are numbered as Sup 2A, Scrap Recovery Facility, Sup 2B, Neptunium Oxide Facility, Sup 2C, Plutonium Oxide Facility. The subject of this safety analysis, the, Plutonium Oxide Facility, will convert nitrate solutions of {sup 238}Pu to plutonium oxide (PuO{sub 2}) powder. All these new facilities incorporate improvements in: (1) engineered barriers to contain contamination, (2) barriers to minimize personnel exposure to airborne contamination, (3) shielding and remote operations to decrease radiation exposure, and (4) equipment and ventilation design to provide flexibility and improved process performance.

  14. State waste discharge permit application, 200-E chemical drain field

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    As part of the Hanford Federal Facility Agreement and Consent Order negotiations (Ecology et al. 1994), the US Department of Energy, Richland Operations Office, the US Environmental Protection Agency, and the Washington State Department of Ecology agreed that liquid effluent discharges to the ground on the Hanford Site which affect groundwater or have the potential to affect ground would be subject to permitting under the structure of Chapter 173-216 (or 173-218 where applicable) of the Washington Administrative Code, the State Waste Discharge Permit Program. As a result of this decision, the Washington State Department of Ecology and the US Department of Energy, Richland Operations Office entered into Consent Order No. DE 91NM-177, (Ecology and DOE-RL 1991). The Consent Order No. DE 91NM-177 requires a series of permitting activities for liquid effluent discharges. This document presents the State Waste Discharge Permit (SWDP) application for the 200-E Chemical Drain Field. Waste water from the 272-E Building enters the process sewer line directly through a floor drain, while waste water from the 2703-E Building is collected in two floor drains, (north and south) that act as sumps and are discharged periodically. The 272-E and 2703-E Buildings constitute the only discharges to the process sewer line and the 200-E Chemical Drain Field.

  15. State waste discharge permit application, 200-E chemical drain field

    International Nuclear Information System (INIS)

    As part of the Hanford Federal Facility Agreement and Consent Order negotiations (Ecology et al. 1994), the US Department of Energy, Richland Operations Office, the US Environmental Protection Agency, and the Washington State Department of Ecology agreed that liquid effluent discharges to the ground on the Hanford Site which affect groundwater or have the potential to affect ground would be subject to permitting under the structure of Chapter 173-216 (or 173-218 where applicable) of the Washington Administrative Code, the State Waste Discharge Permit Program. As a result of this decision, the Washington State Department of Ecology and the US Department of Energy, Richland Operations Office entered into Consent Order No. DE 91NM-177, (Ecology and DOE-RL 1991). The Consent Order No. DE 91NM-177 requires a series of permitting activities for liquid effluent discharges. This document presents the State Waste Discharge Permit (SWDP) application for the 200-E Chemical Drain Field. Waste water from the 272-E Building enters the process sewer line directly through a floor drain, while waste water from the 2703-E Building is collected in two floor drains, (north and south) that act as sumps and are discharged periodically. The 272-E and 2703-E Buildings constitute the only discharges to the process sewer line and the 200-E Chemical Drain Field

  16. A scanning SQUID microscope with 200 MHz bandwidth

    International Nuclear Information System (INIS)

    We developed a scanning DC SQUID microscope with novel readout electronics capable of wideband sensing of RF magnetic fields from 50 to 200 MHz and simultaneously providing closed-loop response at kHz frequencies. To overcome the 20 MHz bandwidth limitation of traditional closed-loop SQUIDs, a flux-modulated closed-loop simultaneously locks the SQUID quasi-static flux and flux-biases the SQUID for amplification of the RF flux up to Φ0/4 in amplitude. Demodulating the SQUID voltage with a double lock-in technique yields a signal representative of both the amplitude and phase of the RF flux. This provides 80 dB of a linear dynamic range with a flux noise density of 4 μΦ0 Hz−1/2 at 200 MHz for a Y Ba2Cu3O7 bi-crystal SQUID at 77 K. We describe the electronics’ performance and present images for RF magnetic field of the travelling wave in a coplanar waveguide, the standing wave in an open-circuited microstrip, and a surface mounted device antenna. (paper)

  17. Safety analysis, 200 Area, Savannah River Plant: Separations area operations

    International Nuclear Information System (INIS)

    The nev HB-Line, located on the fifth and sixth levels of Building 221-H, is designed to replace the aging existing HB-Line production facility. The nev HB-Line consists of three separate facilities: the Scrap Recovery Facility, the Neptunium Oxide Facility, and the Plutonium Oxide Facility. There are three separate safety analyses for the nev HB-Line, one for each of the three facilities. These are issued as supplements to the 200-Area Safety Analysis (DPSTSA-200-10). These supplements are numbered as Sup 2A, Scrap Recovery Facility, Sup 2B, Neptunium Oxide Facility, Sup 2C, Plutonium Oxide Facility. The subject of this safety analysis, the, Plutonium Oxide Facility, will convert nitrate solutions of 238Pu to plutonium oxide (PuO2) powder. All these new facilities incorporate improvements in: (1) engineered barriers to contain contamination, (2) barriers to minimize personnel exposure to airborne contamination, (3) shielding and remote operations to decrease radiation exposure, and (4) equipment and ventilation design to provide flexibility and improved process performance

  18. Hydrogeology of the 200 Areas low-level burial grounds

    International Nuclear Information System (INIS)

    This report presents information derived from the installation of 35 ground-water monitoring wells around six low-level radioactive/hazardous waste burial grounds located in the 200 Areas of the Hanford Site in southeastern Washington State. This information was collected between May 20, 1987 and August 1, 1988. The contents of this report have been divided into two volumes. This volume contains the main text. Volume 2 contains the appendixes, including data and supporting information that verify content and results found in the main text. This report documents information collected by the Pacific Northwest Laboratory at the request of Westinghouse Hanford Company. Presented in this report are the preliminary interpretations of the hydrogeologic environment of six low-level burial grounds, which comprise four waste management areas (WMAs) located in the 200 Areas of the Hanford Site. This information and its accompanying interpretations were derived from sampling and testing activities associated with the construction of 35 ground-water monitoring wells as well as a multitude of previously existing boreholes. The new monitoring wells were installed as part of a ground-water monitoring program initiated in 1986. This ground-water monitoring program is based on requirements for interim status facilities in compliance with the Resource Conservation and Recovery Act (1976)

  19. 200 and 270 GHz SIS receivers development for atmospheric observation

    International Nuclear Information System (INIS)

    Superconducting mixers have been developed for observations of atmospheric minor constituents such as ClO and ozone at Communications Research Laboratory. This paper describes the work at development of 200 and 270 GHz SIS mixers. Nb/AlOx/Nb junctions were fabricated at Nobeyama Radio Observatory. The base Nb layer 200 nm, the Al (AlOx) insulation layer, and the counter Nb electrode 150 nm are sputtered. The area outside of a junction defined by etching of the counter electrode is insulated by anodized Nb layer and sputtered SiO2. After sputtering thick SiO2 layer on the whole wafer, a contact hole is made by etching. The thickness of the wiring Nb layer is 500 nm. The junctions are formed on the 250 μm thick fused quartz substrate. After the process of the junction fabrication, the quartz substrate is shaved from the back side until 150 μm thickness. Each junction for 270 GHz mixer has an area of about 1 μm 2 . The normal resistance of the six junctions series array is around 70 Ω. The mixer block has a reduced waveguide (1.2 x 0.1 mm for 200 GHz and 0.98 x 0. 1 mm for 270 GHz). The waveguide has two tuners in addition to a fixed backshort cavity. This configuration can allow to realize the lower embedding impedance, and less sensitive to the position of the tuners. The SIS mixers are cooled in a closed cycle He refrigerator. The LO is optically injected through a Fabry Perot interferometer. The 5--7 GHz IF is fed to a HEMT amplifier cooled at 15 K. The authors have started a preliminary measurement of the noise temperature of the SIS receivers, and comparing with calculated DSB receiver noise temperature assuming 3-port model. They continue to improve the performance of the SIS mixers now. They intend that the receivers shall be utilized for atmospheric monitor from next winter

  20. The vacuolar potential of Characean cells subjected to electromagnetic radiation in the range 200-8,200 MHz

    Energy Technology Data Exchange (ETDEWEB)

    Barsoum, Y.H.; Pickard, W.F.

    1982-01-01

    Single giant cells of Chara braunii and Nitella flexilis were placed in a microstrip exposure apparatus and subjected to bursts of electromagnetic radiation (carrier frequencies from 200 to 8,200 MHz) at a nominal power level of 100 W/m2. The vacuolar potential was monitored with a micropipette, and offsets as low as 1 microV could be resolved in real time by suitable filtering and signal averaging; under these conditions, no offsets of the vacuolar potential were detected. At much higher power levels (corresponding to greater than or equal to 2 V rms between microstrip and ground plane), the slow hyperpolarizing ramp reported at lower frequencies could be seen but, because of insufficient power, could not be accurately measured. It appeared to decay beyond 500 MHz and to be absent at and above 950 MHz. To investigate reports that snail neurons irradiated for 1 h at 2,450 MHz and approximately 15.5 W/kg developed lowered membrane resistivities, Characean cells were exposed in the microstrip apparatus for 1 h at 2,450 MHz and 230 W/m2; their membrane resistivities were found to be lowered about 18.5%.

  1. 200 more puzzling physics problems with hints and solutions

    CERN Document Server

    Gnädig, Péter; Vigh, Máté

    2016-01-01

    Like its predecessor, 200 Puzzling Physics Problems, this book is aimed at strengthening students' grasp of the laws of physics by applying them to situations that are practical, and to problems that yield more easily to intuitive insight than to brute-force methods and complex mathematics. The problems are chosen almost exclusively from classical, non-quantum physics, but are no easier for that. They are intriguingly posed in accessible non-technical language, and require readers to select an appropriate analysis framework and decide which branches of physics are involved. The general level of sophistication needed is that of the exceptional school student, the good undergraduate, or the competent graduate student; some physics professors may find some of the more difficult questions challenging. By contrast, the mathematical demands are relatively minimal, and seldom go beyond elementary calculus. This further book of physics problems is not only instructive and challenging, but also enjoyable.

  2. ECFA workshop on LEP 200. Vol. 1 and 2

    International Nuclear Information System (INIS)

    On the initiative of the European Committee for Future Accelerators, a workshop was organized to study experimental and theoretical aspects of the physics feasible at LEP with the beam energy increased to its design value of 100 GeV per beam. These two volumes provide the written versions of the reports presented by nine working groups to the workshop, as well as the presentations on the machine upgrade itself and the potential of hadron colliders and of HERA for LEP 200 physics. Each working group studied a specific topic, evaluating in some detail the requirements both for the detectors and for the machine of W mass measurements, W decay properties, W production dynamics, electroweak radiative corrections, two-photon physics, new heavy quarks and leptons, Higgs particles, supersymmetric particles, and composite models. The proceedings also include some of the more detailed work done in the framework of the working groups. (orig.)

  3. Study on a computerized compact simulator of NHR-200

    International Nuclear Information System (INIS)

    A fully computerized compact simulator is studied in accordance with the engineering practical need of NHR-200. A SUN SPARC 2 stand-alone workstation is selected as its computer system and multi-task structure of software is employed. Simulation program is derived from the RETRAN-02 code. The standard I/O devices are used as its interface equipment and the man-machine interface graphic program is coded on the basis of X Window System. Shared memory and semaphores are used for inter-task communication and a timer is used in real-time control of tasks. Its accuracy and simulation speed are verified by using several typical accident transients. The accuracy and speed are perfectly able to meet the requirements of engineering simulation. It is useful for normal and accident transient analysis, engineering study and design, reactor operation support and personnel training

  4. Fall 1998 200 East area biological vector contamination report

    International Nuclear Information System (INIS)

    The purpose of this report is to document the investigation into the cause of the spread of radioactive contamination in September and October 1998 at the Hanford Site's 200 East Area and its subsequent spread to the City of Richland Landfill; identify the source of the contamination; and present corrective actions. The focus and thrust of managing the incident was based on the need to accomplish the following, listed in order of importance: (1) protect the health and safety of the Site workers and the public; (2) contain and control the spread of contamination; (3) identify the source of contamination and the pathways for its spread; and (4) identify the causal factors enabling the contamination

  5. Fall 1998 200 East area biological vector contamination report

    Energy Technology Data Exchange (ETDEWEB)

    CONNELL, D.J.

    1999-03-17

    The purpose of this report is to document the investigation into the cause of the spread of radioactive contamination in September and October 1998 at the Hanford Site's 200 East Area and its subsequent spread to the City of Richland Landfill; identify the source of the contamination; and present corrective actions. The focus and thrust of managing the incident was based on the need to accomplish the following, listed in order of importance: (1) protect the health and safety of the Site workers and the public; (2) contain and control the spread of contamination; (3) identify the source of contamination and the pathways for its spread; and (4) identify the causal factors enabling the contamination.

  6. Pulsar polarisation below 200 MHz: Average profiles and propagation effects

    CERN Document Server

    Noutsos, A; Kondratiev, V I; Weltevrede, P; Verbiest, J P W; Karastergiou, A; Kramer, M; Kuniyoshi, M; Alexov, A; Breton, R P; Bilous, A V; Cooper, S; Falcke, H; Grießmeier, J -M; Hassall, T E; Hessels, J W T; Keane, E F; Osłowski, S; Pilia, M; Serylak, M; Stappers, B W; ter Veen, S; van Leeuwen, J; Zagkouris, K; Anderson, K; Bähren, L; Bell, M; Broderick, J; Carbone, D; Cendes, Y; Coenen, T; Corbel, S; Eislöffel, J; Fender, R; Garsden, H; Jonker, P; Law, C; Marko, S; Masters, J; Miller-Jones, J; Molenaar, G; Osten, R; Pietka, M; Rol, E; Rowlinson, A; Scheers, B; Spreeuw, H; Staley, T; Stewart, A; Swinbank, J; Wijers, R; Wijnands, R; Wise, M; Zarka, P; van der Horst, A

    2015-01-01

    We present the highest-quality polarisation profiles to date of 16 non-recycled pulsars and four millisecond pulsars, observed below 200 MHz with the LOFAR high-band antennas. Based on the observed profiles, we perform an initial investigation of expected observational effects resulting from the propagation of polarised emission in the pulsar magnetosphere and the interstellar medium. The predictions of magnetospheric birefringence in pulsars have been tested using spectra of the pulse width and fractional polarisation from multifrequency data. The derived spectra offer only partial support for the expected effects of birefringence on the polarisation properties, with only about half of our sample being consistent with the model's predictions. It is noted that for some pulsars these measurements are contaminated by the effects of interstellar scattering. For a number of pulsars in our sample, we have observed significant variations in the amount of Faraday rotation as a function of pulse phase, which is possi...

  7. Magnetism of liquid 3He up to 200 T

    International Nuclear Information System (INIS)

    We report measurements of nuclear magnetism of degenerate liquid 3He below 0.1 K. Nuclear polarization up to 60% was transiently obtained by rapid melting of a 80% polarized 3He solid. From simultaneous measurements of the magnetization and of the heat released during the relaxation towards magnetic equilibrium, we deduce the magnetization dependence of the free energy of the liquid, and hence the magnetization curve up to 200 T. At 26 bar and 80 mK, we find that the susceptibility decreases with increasing magnetization. This rules out any significant metamagnetism of the liquid, in contradiction with former expectations. In order to confirm this behaviour by a static experiment, we have developed a torque magnetometer to carry out precision measurements of the equilibrium magnetization up to 30 T (corresponding to a 12% polarization) and at 50 mK. Preliminary results of this experiment are reported. (orig.)

  8. Results of 200 KW fuel cell evaluation programs

    Energy Technology Data Exchange (ETDEWEB)

    Torrey, J.M.; Merten, G.P. [SAIC, San Diego, CA (United States); Binder, M.J. [Army Construction Engineering Research Labs., Champaign, IL (United States)] [and others

    1996-12-31

    Science Applications International Corporation (SAIC) has installed six monitoring systems on ONSI Corporation 200 kW phosphoric acid fuel cells. Three of the systems were installed for the U.S. Army Construction Engineering Research Laboratories (USACERL) which is coordinating the Department of Defense (DoD) fuel cell Demonstration Program and three were installed under a contract with the New York State Energy Research and Development Authority (NYSERDA). Monitoring of the three NYSERDA sites has been completed. Monitoring systems for the DoD fuel cells were installed in August, 1996 and thus no operating data was available at the time of this writing, but will be presented at the Fuel Cell Seminar. This paper will present the monitoring configuration and research approach for each program. Additionally, summary performance data is presented for the completed NYSERDA program.

  9. User-calibration of Mettler AT200 analytical balance

    International Nuclear Information System (INIS)

    The purpose of this technical implementing procedure (TIP) is to describe the calibration of the Mettler AT200 analytical balance or similar type balance (henceforth called the balance). This balance is used for activities of the Scientific Investigation Plan (SIP) ''Metal Barrier Selection and Testing'' (SIP-CM-01, WBS nr. 1.2.2.5.1). In particular, it will be used for Activity E-20-50, ''Long-Term Corrosion Studies.'' The balance will be used for weighing test specimens and reagent chemicals. However, it is not limited to these uses. The calibration procedures consist of activating the internal (self) calibration of the apparatus, and weighing and recording of traceable standards. The balance is equipped with self (internal) calibration and linearization capabilities. It has an internal (built in) set of weights which are used for self calibration. The standard weights are traceable to National Institute of Standards and Technology (NIST)

  10. Optimization of 200 kV electrostatic accelerator

    Directory of Open Access Journals (Sweden)

    M Nazmabadi

    2015-09-01

    Full Text Available Optimizations on 200 kV electrostatic accelerator have been done in order to increasing ion current on target, improving vacuum condition and reduction in x-rays emission, increasing stability of high voltage power supply and reaching much greater achievable voltage value. The accelerator tube has most important effect on beam tracing in the electrostatic accelerators. So precautions most be considered in designing and constructing of this part. In order to finding permissible tolerances in construction and assembling of 200 kV electrostatic accelerator column, first the effects of angle deviation of a part from accelerator axis on beam track in the accelerator tube was simulated with Simion 7.0 computer program. We found that in order to prevent beam lost, the tolerances of balancing and co-centering of each part should be smaller than 0.1 mm. Each part of accelerator tube constructed by tolerances lower than 0.05 mm. Ultrasonic cleaning method used in pre-assembling process of parts. Because of its excellences, in the new tube we used borosilicate glass instead of high density alumina as insulators between the metallic electrodes. After three days of working vacuum pumps the system reached to 8.0×10-7 and after months to 5.0×10-7 ultimate pressure values. Measurements showed that by these considerations the maximum of reachable ion current on target was 1.1 mA which increased 50% compared to old machine, while x-ray emission intensity was increased by 25%. Optimizations of high voltage power supply are now under studies and tests

  11. Safety assessment for the proposed pilot-scale treatability tests for the 200-UP-1 and 200-ZP-1 groundwater operable units. Revision 1

    International Nuclear Information System (INIS)

    This safety assessment provides an analysis of the proposed pilot-scale treatability test activities to be and conducted within the 200 Area groundwater operable units on the Hanford Site. The 200-UP-1 and 200-ZP-1 operable units are located in the 200 West Area of the Hanford Site. These tests will evaluate an ion exchange (IX) water purification treatment system and granular activated carbon (GAC). A detailed engineering analysis of (GAC) adsorption for remediation of groundwater contamination. A detailed engineering analysis of the IX treatment system. The principal source of information for this assessment, states that the performance objective of the treatment systems is to remove 90% of the uranium and technetium-99 (99Tc) from the extracted groundwater at the 200-UP-1 site. The performance objective for 200-ZP-1 is to remove 90% of the carbon tetrachloride (CCl4), chloroform, and trichloroethylene (TCE) from the extracted groundwater

  12. CKY-200型土工离心机研制%Research and Design of Geotechnical Centrifuge of CKY-200

    Institute of Scientific and Technical Information of China (English)

    刘小刚; 王新伦

    2012-01-01

    The 200g.t geotechnical centrifuge had three layers so that the different systems can be isolatedThe linear motion ball guide was designed between the pull beam and the swing arm supporting, and a monitor system was also designed for the unbalance force.The linkage mechanism can be formed by applying the hinges (pins) between hangers and the swing arm,and the same as between hangers and plat-fomuThus the pitman arm and the tangential exciting force of the shaking table can be weakenedln addition the electric system of the centrifuge has several function modules,such as the static data acquisition system, photo,photography,the dynamic balance system and automatic regulate systeiruFurthermore ,the acceleration control accuracy of the driving system was analyzedThe practical application demonstrates that the stability of the acceleration is less than (±0.5)%F.S/4h and the transmission error of the static data acquisition system is less than 0.015%.%容量为200g.t的CKY-200型土工离心机采用三层布局形式,各系统相对隔离;臂架与转臂支承间采用直线导轨系统联接,并增设不平衡力监测系统;吊篮的吊耳与转臂、吊耳与工作平台间采用铰链(销轴)联接,以削弱安装于吊篮的振动台工作时产生的垂臂向和切向振动冲击.电气系统具备静态数采、摄影、摄像、动平衡检测与自动调整等功能.分析了拖动系统加速度控制精度.试验表明:加速度稳定度≤(±0.5)%F.S/4h;静态数采系统的相对传输误差≤0.015%.

  13. Návrh podvozku VUT200 TwinCobra

    OpenAIRE

    Novák, Josef

    2015-01-01

    Hlavním cílem diplomové práce je návrh variant konstrukčního řešení uspořádání a zatahování hlavního podvozku letounu VUT200 TwinCobra. Pro každou variantu je určen rozvor respektive rozchod podvozkových noh v závislosti na poloze hlavního podvozku, která je volena vzhledem k možnostem zatažení podvozku do draku letounu. Pro vybranou variantu jsou sledovány další cíle diplomové práce - určení případů zatížení při přistání podle požadavků předpisu CS 23 a pevnostní analýza dílců podvozkové noh...

  14. Applications of magnetic resonance imaging at 200 MHz

    International Nuclear Information System (INIS)

    In this thesis the construction and testing of an NMR microimaging system based on a WM200 console and 4.7T 89mm bore magnet is described. This imaging system was assembled by the author and used for small animal imaging. Good image quality was obtained. NMR imaging of small animals is demonstrated using this system in the brain of the rat and the abdomen of the mouse. The possibility of using NMR imaging in conjunction with the technique of microdialysis is also demonstrated and the ability of the system to monitor the occurrence of lesions in rat brain is explored. In the second part of this, thesis a novel projection gradient coil design, to be used for remote MRI, is introduced and its construction described. Such open systems will widen the medical and non-medical applications of MRI. Simple theoretical solutions for the generation of linear gradients, which may form the basis of future designs, are presented. The practical feasibility of such systems is clearly demonstrated through the construction and refinement of a simple projection gradient system. Finally, the construction and successful testing of a complete remote imaging probe is described. (author)

  15. Collective dipole rotational bands in the A ∼ 200 region

    International Nuclear Information System (INIS)

    Rotational oblate bands consisting of regular sequences of magnetic dipole transitions have recently been identified in 196-200Pb. Their observation indicates a drastic change in the high-spin configurations between the Hg, Tl and 194Pb nuclei, in which SD bands are clearly observed, and the heavier Pb isotopes, where these weakly deformed oblate structures see to dominate. Angular correlation ratios show the transitions to be dipoles. Their magnetic nature can be deduced from intensity measurements, and they are characterized by small dynamic moments of inertia. Several of the bands have been interpreted as being built on high-K two-proton configurations coupled to an aligned pair of i13/2 neutrons in the even A nuclei, and to either one or three i13/2 neutrons in the odd A nuclei. Cranked shell model calculations predict the alignment of a pair of i13/2 neutrons (the AB crossing) at ω ∼ 0.18 MeVℎ-1. The higher frequency crossing at ω ∼ 0.4 MeVℎ-1 may be due to the alignment of f5/2 neutrons, h11/2 protons, or both. 17 refs., 4 figs

  16. Fast circuit breakers for 200 kA currents

    International Nuclear Information System (INIS)

    A circuit breaker operated by mechanical rupture, capable of opening very high currents in times of the order of ten microseconds has been realized. A copper conductor in the form of a T, fragilized at the joint of the arms and the leg, is ruptured by oil under a pressure of 3 kbars. This pressure is obtained by the magnetic forces of a 600 kA current pulse flowing in a coaxial conductor system. Current flowing in an inductive storage coil is transferred onto a fuse in 9 microseconds. The subsequent explosion of the fuse can either open the circuit and absorb all the stored energy or transfer it to any desired load. The switch is sufficiently reisolated to withstand the voltage peak thus created. A 200 kA current has thus been opened in 20 microseconds and a 9 kV overvoltage sustained. The system, because of its inherent symmetry, can be lengthened to obtain any desired current carrying capacity and requires a relatively small command energy

  17. ASASSN-14ae: A Tidal Disruption Event at 200 Mpc

    CERN Document Server

    Holoien, Thomas W -S; Bersier, D; Kochanek, C S; Stanek, K Z; Shappee, B J; Grupe, D; Basu, U; Beacom, J F; Brimacombe, J; Brown, J S; Davis, A B; Jencson, J; Pojmanski, G; Szczygiel, D M

    2014-01-01

    ASASSN-14ae is a candidate tidal disruption event (TDE) found at the center of SDSS J110840.11+340552.2 ($d\\simeq200$ Mpc) by the All-Sky Automated Survey for Supernovae (ASAS-SN), a global array of 14-cm telescopes. The host galaxy is an early type spiral with no signs of an active galactic nucleus (AGN) and with little recent star formation. We present follow-up photometric and spectroscopic observations of the source, including optical data from ground-based telescopes and ultraviolet and optical data from Swift. From blackbody fits to the host-subtracted spectral energy distribution, we find that the transient had a peak luminosity of $L\\simeq8\\times10^{43}$ erg s$^{-1}$ and a total integrated energy of $E\\simeq1.5\\times10^{50}$ ergs over the $\\sim3$ months of observations presented. The blackbody temperature of the transient remains roughly constant at $T\\sim20,000$ K while the luminosity declines by nearly 1.5 orders of magnitude during this time, a drop that is most consistent with an exponential, $L\\p...

  18. Calibration of the Nikon 200 for Close Range Photogrammetry

    Energy Technology Data Exchange (ETDEWEB)

    Sheriff, Lassana; /City Coll., N.Y. /SLAC

    2010-08-25

    The overall objective of this project is to study the stability and reproducibility of the calibration parameters of the Nikon D200 camera with a Nikkor 20 mm lens for close-range photogrammetric surveys. The well known 'central perspective projection' model is used to determine the camera parameters for interior orientation. The Brown model extends it with the introduction of radial distortion and other less critical variables. The calibration process requires a dense network of targets to be photographed at different angles. For faster processing, reflective coded targets are chosen. Two scenarios have been used to check the reproducibility of the parameters. The first one is using a flat 2D wall with 141 coded targets and 12 custom targets that were previously measured with a laser tracker. The second one is a 3D Unistrut structure with a combination of coded targets and 3D reflective spheres. The study has shown that this setup is only stable during a short period of time. In conclusion, this camera is acceptable when calibrated before each use. Future work should include actual field tests and possible mechanical improvements, such as securing the lens to the camera body.

  19. The Atacama Cosmology Telescope: CMB Polarization at $200<\\ell<9000$

    CERN Document Server

    Naess, Sigurd; McMahon, Jeff; Niemack, Michael D; Addison, Graeme E; Ade, Peter A R; Allison, Rupert; Amiri, Mandana; Baker, Andrew; Battaglia, Nick; Beall, James A; de Bernardis, Francesco; Bond, J Richard; Britton, Joe; Calabrese, Erminia; Cho, Hsiao-mei; Coughlin, Kevin; Crichton, Devin; Das, Sudeep; Datta, Rahul; Devlin, Mark J; Dicker, Simon R; Dunkley, Joanna; Dünner, Rolando; Fowler, Joseph W; Fox, Anna E; Gallardo, Patricio; Grace, Emily; Gralla, Megan; Hajian, Amir; Halpern, Mark; Henderson, Shawn; Hill, J Colin; Hilton, Gene C; Hilton, Matt; Hincks, Adam D; Hlozek, Renée; Ho, Patty; Hubmayr, Johannes; Huffenberger, Kevin M; Hughes, John P; Infante, Leopoldo; Irwin, Kent; Jackson, Rebecca; Klein, Jeff; Koopman, Brian; Kosowsky, Arthur; Li, Dale; Louis, Thibaut; Lungu, Marius; Madhavacheril, Mathew; Marriage, Tobias A; Maurin, Loïc; Menanteau, Felipe; Moodley, Kavilan; Munson, Charles; Newburgh, Laura; Nibarger, John; Nolta, Michael R; Page, Lyman A; Pappas, Christine; Partridge, Bruce; Rojas, Felipe; Schmitt, Benjamin; Sehgal, Neelima; Sherwin, Blake D; Sievers, Jon; Simon, Sara; Spergel, David N; Staggs, Suzanne T; Switzer, Eric R; Thornton, Robert; Trac, Hy; Tucker, Carole; Van Engelen, Alexander; Ward, Jon; Wollack, Edward J

    2014-01-01

    We report on measurements of the cosmic microwave background (CMB) and celestial polarization at 146 GHz made with the Atacama Cosmology Telescope Polarimeter (ACTPol) in its first three months of observing. Four regions of sky covering a total of 270 square degrees were mapped with an angular resolution of $1.3'$. The map noise levels in the four regions are between 11 and 17 $\\mu$K-arcmin. We present TT, TE, EE, TB, EB, and BB power spectra from three of these regions. The observed E-mode polarization power spectrum, displaying six acoustic peaks in the range $200<\\ell<3000$, is an excellent fit to the prediction of the best-fit cosmological models from WMAP9+ACT and Planck data. The polarization power spectrum, which mainly reflects primordial plasma velocity perturbations, provides an independent determination of cosmological parameters consistent with those based on the temperature power spectrum, which results mostly from primordial density perturbations. We find that without masking any point sou...

  20. Computerized tomographic studies in cerebral palsy. Analysis of 200 cases

    Energy Technology Data Exchange (ETDEWEB)

    Sugie, Y. (Tokyo Women' s Medical Coll. (Japan))

    1981-09-01

    Computed tomographic (CT) findings in 200 children with cerebral palsy (CP) were analysed from the viewpoint of clinical manifestations, disease complications and etiological factors. CT scans of 135 cases (67.5%) were found to be abnormal and there were 14 (7%) borderline cases. The major abnormality found on CT scans was cerebral atrophy. Other important changes included focal or diffuse low density area in the brain tissue, congenital malformation, and cerebellar atrophy. From the clinical point of view, a large number of patients with spastic tetraplegia and spastic diplegia showed highly abnormal CT scans. On the other hand, in patients with spastic monoplegia, spastic paraplegia, and athetotic type, CT findings were normal or revealed only minor cerebral atrophy. Most children showing asymmetric clinical symptoms had corresponding asymmetric CT abnormalities which included ventricular enlargement, low density area in the brain tissue, and hemispherical volume. There was a significant correlation between the severity of physical impairment and the extent of CT abnormalities. Severely affected children had grossly abnormal CT scans such as hydranencephaly, polycystic change, and extensive cerebral atrophy. In the patients complicated with epilepsy, the incidence and severity of abnormal CT were higher than those of non-epileptic patients. Mentally retarded patients had variable enlargement of the subarachnoidal space depending on the severity of their mental retardation. Patients with suspected postnatal etiology also had high incidence of severe CT abnormality. CT scan is a valuable tool for evaluating patients with CP and in some cases, possible etiology of the disease may be discovered.

  1. Ducom 200, a new hybrid gas nuclear approach

    International Nuclear Information System (INIS)

    Full text: Nowadays nuclear energy is facing an increasingly tough competition with other energy sources in many countries. Particularly, in places where gas is available at low prices, combined cycle gas turbine plants (CCGT) appear as formidable competitors against nuclear power plants. The relative cost composition of electric power is different in gas and nuclear generation. In the nuclear industry, operation and maintenance (O and M) and fuel costs are relatively low, while construction costs represent the major component of investment. On the other hand for the CCGT, fuel costs are higher than capital costs. Therefore, the existing relation between the price of gas and the capital cost of nuclear plants mostly determines the economic competitiveness between both technologies, which varies between regions. Recently, a technical analysis was presented in order to complement the advantages of gas turbines and nuclear power plants, leading to a great reduction in energy generation costs. This work presents a new proposal of gas-nuclear synergism, especially focused on the necessities of developing countries. These countries are usually interested in low and medium power nuclear reactors, for energy production and desalinisation. The proposed system is called DUCOM 200, and it has some advantages similar to combined cycle gas turbines, but using present generation LWR Nuclear power plants

  2. Environmental emergency planning regulations under section 200 of CEPA, 1999

    International Nuclear Information System (INIS)

    The federal government is under pressure to adopt adequate emergency management programs which are in agreement with international standards and best practices to address incidents of any kind. It is expected that regulations will be put into effect in early 2003 by the federal government under section 200 of the Canadian Environmental Protection Act 1999 (CEPA 1999). These regulations would require the development and implementation of Environmental Emergency Plans covering 174 substances (with their associated thresholds) that could harm human health or environmental quality if released. Sixteen of the substances are already in the List of Toxic Substances under CEPA 1999 or proposed for addition to the List. As work is concluded on the assessment of the remaining CEPA toxics and other hazardous substances, amendments will be submitted to the regulations. The intent and development process of this regulation was reviewed by the author. The requirements for Canadian facilities that would be subjected to the proposed regulation concerning environmental emergency prevention, preparedness, response and recovery (PPRR) plans were also outlined. 10 refs., 2 tabs

  3. 41 CFR 301-71.200 - Who must review and sign travel claims?

    Science.gov (United States)

    2010-07-01

    ... travel claims? 301-71.200 Section 301-71.200 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES AGENCY RESPONSIBILITIES 71-AGENCY TRAVEL ACCOUNTABILITY REQUIREMENTS Travel Claims for Reimbursement § 301-71.200 Who must review and sign travel...

  4. 17 CFR 200.19a - Director of the Division of Trading and Markets.

    Science.gov (United States)

    2010-04-01

    ... Trading and Markets. 200.19a Section 200.19a Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.19a Director of the Division of Trading and Markets. The Director of the Division of Trading and Markets is responsible to the Commission for the administration and execution...

  5. 21 CFR 200.10 - Contract facilities (including consulting laboratories) utilized as extramural facilities by...

    Science.gov (United States)

    2010-04-01

    ... laboratories) utilized as extramural facilities by pharmaceutical manufacturers. 200.10 Section 200.10 Food and... GENERAL General Provisions § 200.10 Contract facilities (including consulting laboratories) utilized as...) The Food and Drug Administration is aware that many manufacturers of pharmaceutical products...

  6. Laboratory Diagnosis and Clinical Profile of Anti-p200 Pemphigoid

    NARCIS (Netherlands)

    Meijer, Joost M; Diercks, Gilles F H; Schmidt, Enno; Pas, Hendri H; Jonkman, Marcel F

    2016-01-01

    Importance: Anti-p200 pemphigoid is a rare subepidermal autoimmune blistering disease characterized by autoantibodies against a 200-kDa protein in the basement membrane zone. Anti-p200 pemphigoid is probably often misdiagnosed because of low availability of diagnostic assays and expertise and classi

  7. 17 CFR 200.18 - Director of Division of Corporation Finance.

    Science.gov (United States)

    2010-04-01

    ... Corporation Finance. 200.18 Section 200.18 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.18 Director of Division of Corporation Finance. The Director of the Division of Corporation Finance is responsible to the Commission for the administration of all matters (except...

  8. BAIKAL experiment: Main results obtained with the neutrino telescope NT200.

    OpenAIRE

    Baikal Collaboration

    2006-01-01

    The Baikal Neutrino Telescope NT200 takes data since April 1998. On April 9th, 2005, the 10 Mton scale detector NT200$+$ was put into operation in Lake Baikal. Selected results obtained during 1998-2002 with the neutrino telescope NT200 are presented.

  9. 9 CFR 113.200 - General requirements for killed virus vaccines.

    Science.gov (United States)

    2010-01-01

    ... vaccines. 113.200 Section 113.200 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... REQUIREMENTS Killed Virus Vaccines § 113.200 General requirements for killed virus vaccines. When prescribed in an applicable Standard Requirement or in the filed Outline of Production, a killed virus...

  10. 40 CFR 421.200 - Applicability: Description of the secondary mercury subcategory.

    Science.gov (United States)

    2010-07-01

    ... secondary mercury subcategory. 421.200 Section 421.200 Protection of Environment ENVIRONMENTAL PROTECTION... CATEGORY Secondary Mercury Subcategory § 421.200 Applicability: Description of the secondary mercury... mercury from secondary mercury facilities processing recycled mercuric oxide batteries and other...

  11. Interim remedial measures proposed plan for the 200-ZP-1 Operable Unit, Hanford Site, Washington

    International Nuclear Information System (INIS)

    The purpose of this interim remedial measures (IRM) proposed plan is to present and solicit public comments on the IRM planned for the 200-ZP-1 Operable Unit at the Hanford Site in Washington state. The 200-ZP-1 is one of two operable units that envelop the groundwater beneath the 200 West Area of the Hanford Site

  12. 34 CFR 200.37 - Notice of identification for improvement, corrective action, or restructuring.

    Science.gov (United States)

    2010-07-01

    ... action, or restructuring. 200.37 Section 200.37 Education Regulations of the Offices of the Department of... restructuring. (a) If an LEA identifies a school for improvement or subjects the school to corrective action or restructuring, the LEA must, consistent with the requirements of § 200.36, promptly notify the parent or...

  13. 12 CFR 550.200 - Must I review a prospective account before I accept it?

    Science.gov (United States)

    2010-01-01

    ... accept it? 550.200 Section 550.200 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE... § 550.200 Must I review a prospective account before I accept it? Before accepting a prospective fiduciary account, you must review it to determine whether you can properly administer the account....

  14. Superfund Record of Decision (EPA Region 10): Hanford 200 Area (USDOE), (200-UP-1 Operable Unit), Benton County, WA, February 11, 1997

    International Nuclear Information System (INIS)

    This decision document presents the selected Interim Remedial Action (IRA) for the US Department of Energy (US DOE) Hanford 200-UP-1 Operable Unit (OU), 200 Area, Hanford Site, Benton County, Washington. The selected remedy consists of pumping the highest concentration zone of the contaminated groundwater plume at 200-UP-1 and treatment using the existing Effluent Treatment Facility (ETF) located in the 200 East Area. The selected remedy is intended to reduce contaminant mass within the plume and minimize migration of uranium and technetium-99 from the 200 West Area. The selected remedy will remove and treat these two contaminants of concern, in addition to the specific co-contaminants of nitrate and carbon tetrachloride which exist within the groundwater

  15. Preliminary engineering assessment of treatment alternatives for groundwater from the Hanford 200 Area 200-BP-5 plumes

    International Nuclear Information System (INIS)

    This report presents the results of the Preliminary Engineering Assessment of Treatment Alternatives (PEATA), an engineering evaluation of potential treatment alternatives for groundwater extracted from the 200-BP-5 Area's 216-BY Cribs and 216-B-5 Reverse Well plumes. The primary objective of the PEATA was to identify treatment technologies that are worth further consideration (i.e., treatability testing or a more refined engineering evaluation). It will also provide a basis for evaluating the results of the treatability testing that is currently being conducted on the presumptive remedy of ion exchange with disposal of spent resin and will serve as a guide for selection of other technologies for additional testing. Because there are little data or past experience with groundwater similar to the BY-Crib and B-5 Reverse Well Plumes, treatment efficiencies cannot be predicted with certainty and rigorous treatment system designs and costs cannot be developed. This applies to all alternatives, including the presumptive remedy of ion exchange. The approach for this study was to develop conceptual designs and approximate costs for the treatment technologies that were most likely to be effective on the BY-Crib and B-5 Reverse Well groundwater

  16. Calculo de tanque de PRFV de 200 000 litros de capacidad. // 200 000 liters capacity PRFV tank calculation.

    Directory of Open Access Journals (Sweden)

    J. García de la Figal Costales

    2002-01-01

    Full Text Available La tarea que se acomete es el cálculo a resistencia y rigidez de un tanque para el almacenamiento de agua, de 200 000 litrosde capacidad, construido de plástico reforzado con fibras de vidrio, PRFV. El mismo es cilíndrico vertical, de 8 metros dediámetro por 4.2 metros de altura. Los materiales seleccionados para la conformación de las láminas con las que se haránlos laminados de PRFV, fueron: resina poliéster isosftálica, y fibras de vidrio E.La carga fundamental a soportar por el tanque será la presión debida a la columna de agua en su interior, pero por estar a laintemperie y en zona de playa, se considerará también la acción de las dilataciones debidas a la temperatura, así como laacción de un ciclón.Palabras claves: resistencia, recipiente, composites, elementos finitos._____________________________________________________________________________Abstract.The stress and strains calculation of a water reinforced fiber glass container is carried out by means of a modern FiniteElement program, because the high complexity of calculus. The soported main load is the pressure caused by the column ofwater.Key words: Resistance, vessels, composites, finite elements.

  17. A STUDY OF IRREGULAR ANTIBODIES IN 200 MULTI - TRANSFUSED PATIENTS

    Directory of Open Access Journals (Sweden)

    Rakesh P

    2015-09-01

    Full Text Available BACKGROUND: Alloimmunization is one of the major concern in the management of patients who required repeated blood transfusion as a lifesaving treatment . The knowledge of incidence of such alloantibodies is essential for selecting appropriate red blood cells for transfusion . AIMS: This study was carried out to get the frequency and type of unexpected red cell antibodies in the multi - transfused patient at a tertiary level government hospital in South Gujarat . MATERIALS AND METHODS: This prospective study was carried out in 200 patients who required multiple blood transfusions . The antibody screening was done with 3 & 11 commercial cell screening & identification panel by column agglutination technique (Matrix Gel System & Matrix Erygen AS - ID, Tulip Diagnostics, India at saline & anti - human globulin phase . RESULTS: The overall prevalence of alloimmunization was 7 . 0% . The majority of these had a single alloantibody (11 cases, 84 . 62% whereas the remaining 2 cases (15 . 38% had multiple antibodies . The anti - c and anti - D antibodies comprised the most common alloantibody (27 % each both followed by, anti - N (20%, anti - C (13%, anti - e & anti - M (7% antibodies . Gender & number of blood units were found to be risk factors of alloimmunization in transfused patients . In our study we found females (79% are more prone to alloimmunization . Those who were transfused more than 2 units have higher frequency of alloimmunization . The highest incidence of alloimmunization was observed in obstetrics and sickle cell patients . CONCLUSIONS: The majority of alloantibodies detected in the current study were clinically significant and of mainly belonging to Rh blood group system . Thus pre - transfusion antibody screening on patients’ samples prior to cross - match needs to be initiated in India and we can at - least provide corresponding Rh antigen negative blood to ensure safe transfusion practice

  18. PEROXIDE DESTRUCTION TESTING FOR THE 200 AREA EFFLUENT TREATMENT FACILITY

    Energy Technology Data Exchange (ETDEWEB)

    HALGREN DL

    2010-03-12

    The hydrogen peroxide decomposer columns at the 200 Area Effluent Treatment Facility (ETF) have been taken out of service due to ongoing problems with particulate fines and poor destruction performance from the granular activated carbon (GAC) used in the columns. An alternative search was initiated and led to bench scale testing and then pilot scale testing. Based on the bench scale testing three manganese dioxide based catalysts were evaluated in the peroxide destruction pilot column installed at the 300 Area Treated Effluent Disposal Facility. The ten inch diameter, nine foot tall, clear polyvinyl chloride (PVC) column allowed for the same six foot catalyst bed depth as is in the existing ETF system. The flow rate to the column was controlled to evaluate the performance at the same superficial velocity (gpm/ft{sup 2}) as the full scale design flow and normal process flow. Each catalyst was evaluated on peroxide destruction performance and particulate fines capacity and carryover. Peroxide destruction was measured by hydrogen peroxide concentration analysis of samples taken before and after the column. The presence of fines in the column headspace and the discharge from carryover was generally assessed by visual observation. All three catalysts met the peroxide destruction criteria by achieving hydrogen peroxide discharge concentrations of less than 0.5 mg/L at the design flow with inlet peroxide concentrations greater than 100 mg/L. The Sud-Chemie T-2525 catalyst was markedly better in the minimization of fines and particle carryover. It is anticipated the T-2525 can be installed as a direct replacement for the GAC in the peroxide decomposer columns. Based on the results of the peroxide method development work the recommendation is to purchase the T-2525 catalyst and initially load one of the ETF decomposer columns for full scale testing.

  19. Development status of 200 KeV, linear induction accelerator

    International Nuclear Information System (INIS)

    Full text: The Linear Induction Accelerator is being constructed for research and applications of high energy beams with high repetition rate. This paper presents the status of 200 keV, 5 kA, 50 ns, 10 Hz-100 Hz Linear Induction Accelerator (LIA) project undertaken by us. The main challenges involved in this project are development of (i) high power switching modules, (ii) pulse transformer with minimal leakage inductance and (iii) magnetic switches iv) induction cavities. Our scheme starts with a low voltage high current DC system charging a capacitor followed by a chain of compression stages and voltage step-up. The 2.5kV : 20kV first stage pulse transformer with built-in reset arrangement has been designed and fabricated with 6-toroidal amorphous cores of size 160/240/25mm. The total leakage inductance could be minimized to 3.5mH. The coaxially designed next stage pulse compression module has been fabricated and tested for full ratings. Water capacitors have been designed for energy storage at subsequent microsecond time scales. Provided with demineralised water circulation and adequate mechanical support, they are currently under fabrication. A 2.5 W water pulse- forming line (PFL) with water-oil interface is also designed to realize a pulse of 50 ns duration across a matched load with minimum distortion. The PFL is connected to the three induction cavities in parallel by a single output switch and three parallel bunches of cable with 100 kV insulation ratings providing an effective characteristic impedance of 2.5 W. Prototype induction cavities using amorphous cores at 20 kV voltage level have been operated in the adder mode. The graphite field emission diode is connected at the output of the adder consisting of three 75 kV induction modules offering a reflected impedance which matches with that of the PFL

  20. PEROXIDE DESTRUCTION TESTING FOR THE 200 AREA EFFLUENT TREATMENT FACILITY

    International Nuclear Information System (INIS)

    The hydrogen peroxide decomposer columns at the 200 Area Effluent Treatment Facility (ETF) have been taken out of service due to ongoing problems with particulate fines and poor destruction performance from the granular activated carbon (GAC) used in the columns. An alternative search was initiated and led to bench scale testing and then pilot scale testing. Based on the bench scale testing three manganese dioxide based catalysts were evaluated in the peroxide destruction pilot column installed at the 300 Area Treated Effluent Disposal Facility. The ten inch diameter, nine foot tall, clear polyvinyl chloride (PVC) column allowed for the same six foot catalyst bed depth as is in the existing ETF system. The flow rate to the column was controlled to evaluate the performance at the same superficial velocity (gpm/ft2) as the full scale design flow and normal process flow. Each catalyst was evaluated on peroxide destruction performance and particulate fines capacity and carryover. Peroxide destruction was measured by hydrogen peroxide concentration analysis of samples taken before and after the column. The presence of fines in the column headspace and the discharge from carryover was generally assessed by visual observation. All three catalysts met the peroxide destruction criteria by achieving hydrogen peroxide discharge concentrations of less than 0.5 mg/L at the design flow with inlet peroxide concentrations greater than 100 mg/L. The Sud-Chemie T-2525 catalyst was markedly better in the minimization of fines and particle carryover. It is anticipated the T-2525 can be installed as a direct replacement for the GAC in the peroxide decomposer columns. Based on the results of the peroxide method development work the recommendation is to purchase the T-2525 catalyst and initially load one of the ETF decomposer columns for full scale testing.

  1. Characterization of Biofilm in 200W Fluidized Bed Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Michelle H.; Saurey, Sabrina D.; Lee, Brady D.; Parker, Kent E.; Eisenhauer, Emalee ER; Cordova, Elsa A.; Golovich, Elizabeth C.

    2014-09-29

    Contaminated groundwater beneath the 200 West Area at the Hanford Site in Southeast Washington is currently being treated using a pump and treat system to remove organics, inorganics, radionuclides, and metals. A granular activated carbon-based fluidized bed reactor (FBR) has been added to remove nitrate, hexavalent chromium and carbon tetrachloride. Initial analytical results indicated the microorganisms effectively reduced many of the contaminants to less than cleanup levels. However shortly thereafter operational upsets of the FBR include carbon carry over, over production of microbial extracellular polymeric substance (biofilm) materials, and over production of hydrogen sulfide. As a result detailed investigations were undertaken to understand the functional diversity and activity of the microbial community present in the FBR over time. Molecular analyses including terminal restriction fragment length polymorphism analysis, quantitative polymerase chain reaction and fluorescent in situ hybridization analyses were performed on the microbial community extracted from the biofilm within the bed and from the inoculum, to determine functional dynamics of the FBR bed over time and following operational changes. Findings from these analyses indicated: 1) the microbial community within the bed was completely different than community used for inoculation, and was likely from the groundwater; 2) analyses early in the testing showed an FBR community dominated by a few Curvibacter and Flavobacterium species; 3) the final sample taken indicated that the microbial community in the FBR bed had become more diverse; and 4) qPCR analyses indicated that bacteria involved in nitrogen cycling, including denitrifiers and anaerobic ammonia oxidizing bacteria, were dominant in the bed. These results indicate that molecular tools can be powerful for determining functional diversity within FBR type reactors. Coupled with micronutrient, influent and effluent chemistry evaluations, a more

  2. CEBAF 200 kV Inverted Electron Gun

    Energy Technology Data Exchange (ETDEWEB)

    Grames, J M; Clark, J; Hansknecht, J; Poelker, M; Stutzman, M L; Suleiman, R; Surles-Law, K.E.L.; BastaniNejad, M

    2011-03-01

    Two DC high volt­age GaAs pho­to­guns have been built at Jef­fer­son Lab based on a com­pact in­vert­ed in­su­la­tor de­sign. One pho­to­gun pro­vides the po­lar­ized elec­tron beam at CEBAF and op­er­ates at 130 kV bias volt­age. The other gun is used for high av­er­age cur­rent life­time stud­ies at a ded­i­cat­ed test fa­cil­i­ty and has been op­er­at­ed at bias volt­age up to 225 kV. The ad­van­tages of high­er DC volt­age for CEBAF in­clude re­duced space-charge emit­tance growth and the po­ten­tial for pro­longed pho­to­cath­ode life­time. How­ev­er, a con­se­quence of op­er­at­ing at high­er volt­ages is the in­creased like­li­hood of field emis­sion or break­down, both of which are un­ac­cept­able. High­lights of the R&D stud­ies lead­ing to­ward a pro­duc­tion 200keV GaAs pho­to­gun for CEBAF will be pre­sent­ed.

  3. Learn from experience: insights of 200+ PACS customers.

    Science.gov (United States)

    Swaton, Norm

    2002-01-01

    This article is based on a PACS study published in June 2001 by KLAS Enterprises. The study offers unique insight into the performance, underlying technology, product depth and breadth, and "real world" issues facing 10 of the leading PACS vendors and their clients as rated at more than 200 of their client sites by CIOs, department directors and vendor executives. The driving force behind this report reflects the heightened interest in PACS systems in general and PACS' contributions to the benefits associated with an electronic medical record. This research was sponsored by 10 healthcare provider organizations (not vendors), ranging from a 150-bed acute-care hospital to a seven-hospital IDN. Most of the data in the report focuses on the use of PACS in the radiology department, since comparatively few sites are using PACS systems in other departments, such as cardiology or pathology. The participating vendors supplied their customer lists, which contributed to the majority of clients surveyed. Clients surveyed in the study vary widely in size, ranging from 50 to 2,000 beds, with about 46 percent of those surveyed having a hospital size of more than 400 beds. The customers represent a broad cross-section of PACS clients, ranging from 10 percent to 95 percent filmless, with large-scale users making up the majority of respondents. Each of the customers were asked to numerically rate their vendor on 28 aspects of performance, as well as to answer 12 questions relating to customer satisfaction. Based on study results, success with PACS can be distilled into some basic principles. There are other issues that will help with a successful PACS selection and implementation, but the following list should help anyone get started. If you are able to focus on and accomplish these few things, you stand a better chance of building and meeting your business case. Pre-sell your PACS concept to the radiologists, technicians, IS/IT staff supporting it and to the referring physicians

  4. Process for producing astatine-211 for radiopharmaceutical use

    International Nuclear Information System (INIS)

    A one-step chemical manipulation is described in combination with a distillation and collection process for producing At-211 comprising; a. providing a target of irradiated Bismuth coated to a predetermined thickness of a backing member, b. providing a vapor-producing still operably connected with a condenser that has a water cooled condensate collector formed of a dry silica gel mesh maintained at a temperature above the freezing point of water, and providing an effluent gas filter that is operably connected to receive effluent gas from the condenser, c. heating the target in the still at a temperature in the range of about 6300-6800C for a time period in the range of 50 to 80 minutes, to evole At-211 vapor from the target, c. providing a dry carrier gas having an oxygen concentration that is sufficient to form Bi/sub 2/O/sub 3/ thereby to essentially preclude vaporization of Bi metal, passing the carrier gas through the still to carry the At-211 vapor to the condenser, and to carry effluent from the condenser to the effluent gas filter, e. eluting At-211 from the condensate collector of the condenser with a controlled volume of eluent containing predetermined solvents that are compatible with a given desired radiopharmaceutical procedure, and f. collecting the At-211 in the controlled volume of eluent for use in the given radiopharmaceutical procedure

  5. miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus

    Institute of Scientific and Technical Information of China (English)

    Cameron M Smith; David I Watson; Mary P Leong; George C Mayne; Michael Z Michael; Bas PL Wijnhoven; Damian J Hussey

    2011-01-01

    AIM:To investigate miR-200 family expression in Barrett's epithelium,gastric and duodenal epithelia,and esophageal adenocarcinoma. METHODS:Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200,ZEB1 and ZEB2 expression.Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS:Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001).In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenal epithelia,and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02),and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02).The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium.We observed significant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION:miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium.

  6. Pulsar polarisation below 200 MHz: Average profiles and propagation effects

    Science.gov (United States)

    Noutsos, A.; Sobey, C.; Kondratiev, V. I.; Weltevrede, P.; Verbiest, J. P. W.; Karastergiou, A.; Kramer, M.; Kuniyoshi, M.; Alexov, A.; Breton, R. P.; Bilous, A. V.; Cooper, S.; Falcke, H.; Grießmeier, J.-M.; Hassall, T. E.; Hessels, J. W. T.; Keane, E. F.; Osłowski, S.; Pilia, M.; Serylak, M.; Stappers, B. W.; ter Veen, S.; van Leeuwen, J.; Zagkouris, K.; Anderson, K.; Bähren, L.; Bell, M.; Broderick, J.; Carbone, D.; Cendes, Y.; Coenen, T.; Corbel, S.; Eislöffel, J.; Fender, R.; Garsden, H.; Jonker, P.; Law, C.; Markoff, S.; Masters, J.; Miller-Jones, J.; Molenaar, G.; Osten, R.; Pietka, M.; Rol, E.; Rowlinson, A.; Scheers, B.; Spreeuw, H.; Staley, T.; Stewart, A.; Swinbank, J.; Wijers, R.; Wijnands, R.; Wise, M.; Zarka, P.; van der Horst, A.

    2015-04-01

    Aims: We present the highest-quality polarisation profiles to date of 16 non-recycled pulsars and four millisecond pulsars, observed below 200 MHz with the LOFAR high-band antennas. Based on the observed profiles, we perform an initial investigation of expected observational effects resulting from the propagation of polarised emission in the pulsar magnetosphere and the interstellar medium. Methods: The polarisation data presented in this paper have been calibrated for the geometric-projection and beam-shape effects that distort the polarised information as detected with the LOFAR antennas. We have used RM Synthesis to determine the amount of Faraday rotation in the data at the time of the observations. The ionospheric contribution to the measured Faraday rotation was estimated using a model of the ionosphere. To study the propagation effects, we have compared our low-frequency polarisation observations with archival data at 240, 400, 600, and 1400 MHz. Results: The predictions of magnetospheric birefringence in pulsars have been tested using spectra of the pulse width and fractional polarisation from multifrequency data. The derived spectra offer only partial support for the expected effects of birefringence on the polarisation properties, with only about half of our sample being consistent with the model's predictions. It is noted that for some pulsars these measurements are contaminated by the effects of interstellar scattering. For a number of pulsars in our sample, we have observed significant variations in the amount of Faraday rotation as a function of pulse phase, which is possibly an artefact of scattering. These variations are typically two orders of magnitude smaller than that observed at 1400 MHz by Noutsos et al. (2009), for a different sample of southern pulsars. In this paper we present a possible explanation for the difference in magnitude of this effect between the two frequencies, based on scattering. Finally, we have estimated the magnetospheric

  7. Roles of methionine oxidation in E200K prion protein misfolding: Implications for the mechanism of pathogenesis in E200K linked familial Creutzfeldt-Jakob disease.

    Science.gov (United States)

    Wang, Zonglin; Feng, Boya; Xiao, Gengfu; Zhou, Zheng

    2016-04-01

    Prion diseases are a group of neurodegenerative diseases caused by prion protein (PrP) conformational changes. More than 30 PRNP gene mutations have been associated with familial prion diseases. E200K-associated familial Creutzfeldt-Jakob disease (fCJD) is the most common inherited prion disease. One of the hallmarks of prion diseases is the accumulation of oxidative damage. The mechanism by which oxidative modification of methionine (Met) residues influence the E200K PrP misfolding remains unclear. Here, we examined the stability, structural change, oligomerization and proteinase K resistance of unoxidized/oxidized E200K PrP and Met-to-Leu mutants. We found that oxidation of surface-exposed Met109/112/129/134/154/166 residues significantly destabilized E200K PrP but had a limited impact on the protein's structure. The oxidation of Met213 was the initial step in the conformational conversion of E200K PrP and facilitated the further oxidation of Met205/206. The oxidation of Met213/205/206 led to the exposure of the inner hydrophobic core, disrupted the overall structure of E200K PrP and induced the formation of large soluble multimers at low pH. In addition, the aggregation behavior of oxidized E200K PrP at the cellular level was investigated using E200K PrP Met-to-Ser mutants. The results showed that M109/112/129/154S or M134/166S mutants were efficiently localized on the cell membrane, whereas the M213/205/206S mutant generated many of aggregated fluorescent dots in the cytoplasm. The present work provides important clues for understanding the special roles of methionine oxidation in E200K PrP misfolding and links oxidative stress and consequent misfolding of oxidative damaged E200K PrP with the pathogenic mechanism of E200K-associated fCJD. PMID:26779934

  8. Brain innate immunity in the regulation of neuroinflammation: therapeutic strategies by modulating CD200-CD200R interaction involve the cannabinoid system.

    Science.gov (United States)

    Hernangómez, Miriam; Carrillo-Salinas, Francisco J; Mecha, Miriam; Correa, Fernando; Mestre, Leyre; Loría, Frida; Feliú, Ana; Docagne, Fabian; Guaza, Carmen

    2014-01-01

    The central nervous system (CNS) innate immune response includes an arsenal of molecules and receptors expressed by professional phagocytes, glial cells and neurons that is involved in host defence and clearance of toxic and dangerous cell debris. However, any uncontrolled innate immune responses within the CNS are widely recognized as playing a major role in the development of autoimmune disorders and neurodegeneration, with multiple sclerosis (MS) Alzheimer's disease (AD) being primary examples. Hence, it is important to identify the key regulatory mechanisms involved in the control of CNS innate immunity and which could be harnessed to explore novel therapeutic avenues. Neuroimmune regulatory proteins (NIReg) such as CD95L, CD200, CD47, sialic acid, complement regulatory proteins (CD55, CD46, fH, C3a), HMGB1, may control the adverse immune responses in health and diseases. In the absence of these regulators, when neurons die by apoptosis, become infected or damaged, microglia and infiltrating immune cells are free to cause injury as well as an adverse inflammatory response in acute and chronic settings. We will herein provide new emphasis on the role of the pair CD200-CD200R in MS and its experimental models: experimental autoimmune encephalomyelitis (EAE) and Theiler's virus induced demyelinating disease (TMEV-IDD). The interest of the cannabinoid system as inhibitor of inflammation prompt us to introduce our findings about the role of endocannabinoids (eCBs) in promoting CD200-CD200 receptor (CD200R) interaction and the benefits caused in TMEV-IDD. Finally, we also review the current data on CD200-CD200R interaction in AD, as well as, in the aging brain. PMID:24588829

  9. Comparison of the Nellcor N-200 and N-3000 pulse oximeters during simulated postoperative activities

    DEFF Research Database (Denmark)

    Lie, C; Kehlet, H; Rosenberg, J

    1997-01-01

    Twenty-six healthy volunteers were monitored simultaneously with the Nellcor N-200 and N-3000 pulse oximeters during nonhypoxaemic simulated postoperative activity. The overall number of registered events (hypoxaemic episodes or loss of signal) was fewer with the N-3000 than with the N-200 (8 vs....... 32, p < 0.00005). Episodes of "desaturation' of > or = 5% from baseline were significantly fewer with the N-3000 than with the N-200 (5 vs. 19, p = 0.0001), and lowest values below 90% occurred nine times on the N-200, but were not seen with the N-3000 (p < 0.00005). Furthermore, episodes owing to...... loss of signal were significantly rarer with the N-3000 than with the N-200 (3 vs. 13, p = 0.001). The Nellcor N-3000 oximeter may offer an advantage over the N-200 model when monitoring patients in the postoperative period....

  10. Tumor-derived vaccines containing CD200 inhibit immune activation: implications for immunotherapy.

    Science.gov (United States)

    Xiong, Zhengming; Ampudia-Mesias, Elisabet; Shaver, Rob; Horbinski, Craig M; Moertel, Christopher L; Olin, Michael R

    2016-09-01

    There are over 400 ongoing clinical trials using tumor-derived vaccines. This approach is especially attractive for many types of brain tumors, including glioblastoma, yet so far the clinical response is highly variable. One contributor to poor response is CD200, which acts as a checkpoint blockade, inducing immune tolerance. We demonstrate that, in response to vaccination, glioma-derived CD200 suppresses the anti-tumor immune response. In contrast, a CD200 peptide inhibitor that activates antigen-presenting cells overcomes immune tolerance. The addition of the CD200 inhibitor significantly increased leukocyte infiltration into the vaccine site, cytokine and chemokine production, and cytolytic activity. Our data therefore suggest that CD200 suppresses the immune system's response to vaccines, and that blocking CD200 could improve the efficacy of cancer immunotherapy. PMID:27485078

  11. SRP engineering and design history, Vol III, 200 F and H Areas

    International Nuclear Information System (INIS)

    This volume combines the record of events relating to the development of design for both the 200-F and H Areas. Chronologically, the definition of plant facilities was first established for the 200-F Area. The second area, 200-H, was projected initially to be a supplementary plutonium separations facility. This history explains the differences in character and capacity of the manufacturing facilities in both areas as production requirements and experience with separations processes advanced

  12. 17 CFR 200.30-1 - Delegation of authority to Director of Division of Corporation Finance.

    Science.gov (United States)

    2010-04-01

    ... 304(d) of the Act (15 U.S.C. 77ddd(d)) and rule 4d-7 thereunder (17 CFR 260.4d-7 of this chapter). (5...). Editorial Note: For Federal Register citations affecting § 200.30-1 see the List of CFR Sections Affected... Director of Division of Corporation Finance. 200.30-1 Section 200.30-1 Commodity and Securities...

  13. SRP engineering and design history, Vol III, 200 F and H Areas

    Energy Technology Data Exchange (ETDEWEB)

    Banick, C.J.

    2000-04-17

    This volume combines the record of events relating to the development of design for both the 200-F and H Areas. Chronologically, the definition of plant facilities was first established for the 200-F Area. The second area, 200-H, was projected initially to be a supplementary plutonium separations facility. This history explains the differences in character and capacity of the manufacturing facilities in both areas as production requirements and experience with separations processes advanced.

  14. Solubility of Naproxen in Polyethylene Glycol 200 + Water Mixtures at Various Temperatures

    OpenAIRE

    Panahi-Azar, Vahid; Soltanpour, Shahla; Martinez, Fleming; Jouyban, Abolghasem

    2015-01-01

    The solubility of naproxen in binary mixtures of polyethylene glycol 200 (PEG 200) + water at the temperature range from 298.0 K to 318.0 K were reported. The combinations of Jouyban-Acree model + van’t Hoff and Jouyban-Acree model + partial solubility parameters were used to predict the solubility of naproxen in PEG 200 + water mixtures at different temperatures. Combination of Jouyban-Acree model with van’t Hoff equation can be used to predict solubility in PEG 200 + water with only four so...

  15. Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish

    Directory of Open Access Journals (Sweden)

    Yuan Liu

    2015-01-01

    Full Text Available Purpose. The small nuclear ribonucleoprotein 200 kDa (SNRNP200 gene is a fundamental component for precursor message RNA (pre-mRNA splicing and has been implicated in the etiology of autosomal dominant retinitis pigmentosa (adRP. This study aims to determine the consequences of knocking down Snrnp200 in zebrafish. Methods. Expression of the Snrnp200 transcript in zebrafish was determined via whole mount in situ hybridization. Morpholino oligonucleotide (MO aiming to knock down the expression of Snrnp200 was injected into zebrafish embryos, followed by analyses of aberrant splicing and expression of the U4/U6-U5 tri-small nuclear ribonucleoproteins (snRNPs components and retina-specific transcripts. Systemic changes and retinal phenotypes were further characterized by histological study and immunofluorescence staining. Results. Snrnp200 was ubiquitously expressed in zebrafish. Knocking down Snrnp200 in zebrafish triggered aberrant splicing of the cbln1 gene, upregulation of other U4/U6-U5 tri-snRNP components, and downregulation of a panel of retina-specific transcripts. Systemic defects were found correlated with knockdown of Snrnp200 in zebrafish. Only demorphogenesis of rod photoreceptors was detected in the initial stage, mimicking the disease characteristics of RP. Conclusions. We conclude that knocking down Snrnp200 in zebrafish could alter regular splicing and expression of a panel of genes, which may eventually trigger rod defects.

  16. A Truncated form of CD200 (CD200S) Expressed on Glioma Cells Prolonged Survival in a Rat Glioma Model by Induction of a Dendritic Cell-Like Phenotype in Tumor-Associated Macrophages12

    Science.gov (United States)

    Kobayashi, Kana; Yano, Hajime; Umakoshi, Akihiro; Matsumoto, Shirabe; Mise, Ayano; Funahashi, Yu; Ueno, Yoshitomo; Kamei, Yoshiaki; Takada, Yasutsugu; Kumon, Yoshiaki; Ohnishi, Takanori; Tanaka, Junya

    2016-01-01

    CD200 induces immunosuppression in myeloid cells expressing its receptor CD200R, which may have consequences for tumor immunity. We found that human carcinoma tissues express not only full-length CD200 (CD200L) but also its truncated form, CD200S. Although CD200S is reported to antagonize the immunosuppressive actions of CD200L, the role of CD200S in tumor immunity has never been investigated. We established rat C6 glioma cell lines that expressed either CD200L or CD200S; the original C6 cell line did not express CD200 molecules. The cell lines showed no significant differences in growth. Upon transplantation into the neonatal Wistar rat forebrain parenchyma, rats transplanted with C6-CD200S cells survived for a significantly longer period than those transplanted with the original C6 and C6-CD200L cells. The C6-CD200S tumors were smaller than the C6-CD200L or C6-original tumors, and many apoptotic cells were found in the tumor cell aggregates. Tumor-associated macrophages (TAMs) in C6-CD200S tumors displayed dendritic cell (DC)-like morphology with multiple processes and CD86 expression. Furthermore, CD3+, CD4+ or CD8+ cells were more frequently found in C6-CD200S tumors, and the expression of DC markers, granzyme, and perforin was increased in C6-CD200S tumors. Isolated TAMs from original C6 tumors were co-cultured with C6-CD200S cells and showed increased expression of DC markers. These results suggest that CD200S activates TAMs to become DC-like antigen presenting cells, leading to the activation of CD8+ cytotoxic T lymphocytes, which induce apoptotic elimination of tumor cells. The findings on CD200S action may provide a novel therapeutic modality for the treatment of carcinomas. PMID:27108386

  17. A Truncated form of CD200 (CD200S Expressed on Glioma Cells Prolonged Survival in a Rat Glioma Model by Induction of a Dendritic Cell-Like Phenotype in Tumor-Associated Macrophages

    Directory of Open Access Journals (Sweden)

    Kana Kobayashi

    2016-04-01

    Full Text Available CD200 induces immunosuppression in myeloid cells expressing its receptor CD200R, which may have consequences for tumor immunity. We found that human carcinoma tissues express not only full-length CD200 (CD200L but also its truncated form, CD200S. Although CD200S is reported to antagonize the immunosuppressive actions of CD200L, the role of CD200S in tumor immunity has never been investigated. We established rat C6 glioma cell lines that expressed either CD200L or CD200S; the original C6 cell line did not express CD200 molecules. The cell lines showed no significant differences in growth. Upon transplantation into the neonatal Wistar rat forebrain parenchyma, rats transplanted with C6-CD200S cells survived for a significantly longer period than those transplanted with the original C6 and C6-CD200L cells. The C6-CD200S tumors were smaller than the C6-CD200L or C6-original tumors, and many apoptotic cells were found in the tumor cell aggregates. Tumor-associated macrophages (TAMs in C6-CD200S tumors displayed dendritic cell (DC-like morphology with multiple processes and CD86 expression. Furthermore, CD3+, CD4+ or CD8+ cells were more frequently found in C6-CD200S tumors, and the expression of DC markers, granzyme, and perforin was increased in C6-CD200S tumors. Isolated TAMs from original C6 tumors were co-cultured with C6-CD200S cells and showed increased expression of DC markers. These results suggest that CD200S activates TAMs to become DC-like antigen presenting cells, leading to the activation of CD8+ cytotoxic T lymphocytes, which induce apoptotic elimination of tumor cells. The findings on CD200S action may provide a novel therapeutic modality for the treatment of carcinomas.

  18. 34 CFR 200.89 - MEP allocations; Re-interviewing; Eligibility documentation; and Quality control.

    Science.gov (United States)

    2010-07-01

    ... determining eligibility and in conducting quality control procedures know the requirements for accurately... documentation; and Quality control. 200.89 Section 200.89 Education Regulations of the Offices of the Department...-interviewing; Eligibility documentation; and Quality control. (a) Allocation of funds under the MEP for...

  19. 30 CFR 243.200 - How do I demonstrate financial solvency?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I demonstrate financial solvency? 243.200 Section 243.200 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS REVENUE MANAGEMENT Financial...

  20. 76 FR 38062 - Airworthiness Directives; Gulfstream Aerospace LP Model Galaxy and Gulfstream 200 Airplanes

    Science.gov (United States)

    2011-06-29

    ... 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034... Aerospace LP Model Galaxy and Gulfstream 200 Airplanes AGENCY: Federal Aviation Administration (FAA), DOT... LP Model Galaxy and Gulfstream 200 airplanes, certificated in any category, serial numbers...

  1. 34 CFR 200.66 - Requirements to ensure that funds do not benefit a private school.

    Science.gov (United States)

    2010-07-01

    ... private school. 200.66 Section 200.66 Education Regulations of the Offices of the Department of Education... private school. (a) An LEA must use funds under subpart A of this part to provide services that supplement, and in no case supplant, the services that would, in the absence of Title I services, be available...

  2. 24 CFR 200.950 - Building product standards and certification program for solar water heating system.

    Science.gov (United States)

    2010-04-01

    ... certification program for solar water heating system. 200.950 Section 200.950 Housing and Urban Development... solar water heating system. (a) Applicable standards. (1) All solar water heating systems shall be... administrator to the manufacturer. Each solar water heating system shall be marked as conforming to UM 100....

  3. 29 CFR 2530.200b-7 - Day of service for employees in the maritime industry.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Day of service for employees in the maritime industry. 2530.200b-7 Section 2530.200b-7 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY... industry. (a) General rule. A day of service in the maritime industry which must, as a minimum, be...

  4. Methodology for completing Hanford 200 Area tank waste physical/chemical profile estimations

    International Nuclear Information System (INIS)

    The purpose of the Methodology for Completing Hanford 200 Area Tank Waste Physical/Chemical Profile Estimations is to capture the logic inherent to completing 200 Area waste tank physical and chemical profile estimates. Since there has been good correlation between the estimate profiles and actual conditions during sampling and sub-segment analysis, it is worthwhile to document the current estimate methodology

  5. 29 CFR 780.200 - Inclusion of forestry or lumbering operations in agriculture is limited.

    Science.gov (United States)

    2010-07-01

    ... agriculture is limited. 780.200 Section 780.200 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR... REGULATIONS EXEMPTIONS APPLICABLE TO AGRICULTURE, PROCESSING OF AGRICULTURAL COMMODITIES, AND RELATED SUBJECTS UNDER THE FAIR LABOR STANDARDS ACT Agriculture as It Relates to Specific Situations Forestry...

  6. 21 CFR 201.200 - Disclosure of drug efficacy study evaluations in labeling and advertising.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Disclosure of drug efficacy study evaluations in labeling and advertising. 201.200 Section 201.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Commissioner of Food and Drugs from the National Academy of Sciences (1969).” As the report notes, this...

  7. 28 CFR 200.1 - Eligibility for Protection under the Convention Against Torture.

    Science.gov (United States)

    2010-07-01

    ... Convention Against Torture. 200.1 Section 200.1 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED... Torture. A removal order under Title V of the Act shall not be executed in circumstances that would violate Article 3 of the United Nations Convention Against Torture and Other Cruel, Inhuman or...

  8. 34 CFR 200.47 - SEA responsibilities for supplemental educational services.

    Science.gov (United States)

    2010-07-01

    ... appropriate supplemental educational services and language assistance in the provision of those services. (b... sound; and (iv) In the case of— (A) A public school, has not been identified under §§ 200.32, 200.33, or... format, including alternative formats upon request, and, to the extent practicable, in a language...

  9. 19 CFR 200.735-114 - Employees required to submit statements.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Employees required to submit statements. 200.735... Employees required to submit statements. Except as provided in § 200.735-114a, the following employees shall submit confidential statements of employment and financial interests: (a)(1) Employees in grade GS-13...

  10. 34 CFR 200.29 - Consolidation of funds in a schoolwide program.

    Science.gov (United States)

    2010-07-01

    ... Register. (2) For purposes of §§ 200.25 through 200.29, the authority to consolidate funds from other...; (iv) Student and parental participation and involvement; (v) Services to private school children; (vi..., State, and local sources in their schoolwide programs. (Authority: 20 U.S.C. 6314, 1413(a)(s)(D),...

  11. 49 CFR 179.200-23 - Tests of pressure relief valves.

    Science.gov (United States)

    2010-10-01

    ...-23 Tests of pressure relief valves. (a) Each valve shall be tested by air or gas for compliance with... 49 Transportation 2 2010-10-01 2010-10-01 false Tests of pressure relief valves. 179.200-23 Section 179.200-23 Transportation Other Regulations Relating to Transportation PIPELINE AND...

  12. 30 CFR 212.200 - Maintenance of and access to records.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Maintenance of and access to records. 212.200 Section 212.200 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE... prices. (3) Costs of mining, processing, handling, and transportation....

  13. 24 CFR 200.936 - Supplementary specific procedural requirements under HUD building products certification program...

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Supplementary specific procedural requirements under HUD building products certification program for solid fuel type room heaters and fireplace stoves. 200.936 Section 200.936 Housing and Urban Development Regulations Relating to Housing and...

  14. 24 CFR 200.77 - Lead-based paint poisoning prevention.

    Science.gov (United States)

    2010-04-01

    ...-based paint poisoning prevention. Requirements set forth in 24 CFR part 35 apply to these programs. ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Lead-based paint poisoning prevention. 200.77 Section 200.77 Housing and Urban Development Regulations Relating to Housing and...

  15. Development of a 200kW multi-fuel type PAFC power plant

    Energy Technology Data Exchange (ETDEWEB)

    Take, Tetsuo; Kuwata, Yutaka; Adachi, Masahito; Ogata, Tsutomu [NTT Integrated Information & Energy System Labs., Tokyo (Japan)

    1996-12-31

    Nippon Telegraph and Telephone Corporation (NFT) has been developing a 200 kW multi-fuel type PAFC power plant which can generate AC 200 kW of constant power by switching fuel from pipeline town gas to liquefied propane gas (LPG) and vice versa. This paper describes the outline of the demonstration test plant and test results of its fundamental characteristics.

  16. Structural Features and In-service Inspection of the LTNHR-200 Pressure Vessel

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The pressure vessel of 200 MW low temperature nuclear heating reactor (LTNHR-200) is the main part of primary pressure boundary and its reasonable and reliable structural design is the key point to assure the safe operation of LTNHR-200. The double-shell pressure vessels were designed. LTNHR-200 pressure vessel meets the condition of Leak Before Break and has a relatively low failure probability. Metal containment (outer pressure vessel) has the similar features to LTNHR-200 pressure vessel. There exists no LOCA and core melting with the double vessel. The in-service inspection of the pressure vessel can be simplified greatly because of the safety and structural features of the reactor.

  17. Fiscal Year 1997 Annual Report for the 100-NR-2, 200-UP-1, and 200-ZP-1 Pump and Treat Operations and Operable Units

    International Nuclear Information System (INIS)

    The Environmental Restoration Contractor (ERC), Bechtel Hanford, Inc., conducts groundwater remediation activities across the Hanford Site for the U.S. Department of Energy. Operable units, as defined under CERCLA, have been established to address groundwater contamination issues in various areas of the Site. Groundwater within these operable units has been contaminated by a variety of chemical and radiological constituents associated with past-practices liquid effluent disposal, as well as accidental leaks and spills. The ERC is currently operating three pump-and-treat systems in the 100 Area: Strontium-90 is being addressed in the 100-NR-2 Operable Unit, while hexavalent chromium is being addressed in the 100-KR-4 and 100-HR-3 Operable Units. In the 200 Area, technetium-99, uranium, carbon tetrachloride, and nitrate are being addressed in the 200-UP-1 Operable Unit, while carbon tetrachloride, trichloroethene, and chloroform are being addressed in the 200-ZP-1 Operable Unit

  18. Study on Training of 200m Running during Junior Middle School%对初中200米跑训练的研究

    Institute of Scientific and Technical Information of China (English)

    陈俊达

    2012-01-01

    目的:探讨初中200米跑切实有效的训练方法,提高初三学生中考体育加试成绩。方法:采取不同的训练方法进行对照实验的研究方法,对所得结果进行数理统计与分析。结果:实验组采取综合训练方法,200米跑成绩比对照组有显著性提高(P〈0.05)。结论:采取科学的训练方法,并合理地安排训练内容,可以大幅度提高初中200米跑成绩。建议:采取本文的训练方法,将全面提高初中生中考体育加试成绩。%Objective: To explore the 200m running effective training methods of junior middle school, improve grade students in senior high school entrance examination of physical tests. Methods : different training methods for controlled experiments, the results of statistics and analysis are made. Results: the experimental group take comprehensive training method, 200m race result had significantly increased than the control group ( P 〈 0.05 ). Conclusion: the use of scientific training methods, and reasonable arrangements for the training content, can greatly improve the junior middle school 200m race result. Suggestion: Taking the training methods in this paper will improve the junior middle school students in senior high school entrance examination of physical tests.

  19. Melanoma Cell Expression of CD200 Inhibits Tumor Formation and Lung Metastasis via Inhibition of Myeloid Cell Functions

    OpenAIRE

    Talebian, Fatemeh; Liu, Jin-Qing; Liu, Zhenzhen; Khattabi, Mazin; He, Yukai; Ganju, Ramesh; Bai, Xue-feng

    2012-01-01

    CD200 is a cell surface glycoprotein that functions through engaging CD200 receptor on cells of the myeloid lineage and inhibits their functions. Expression of CD200 has been implicated in a variety of human cancer cells including melanoma cells and has been thought to play a protumor role. To investigate the role of cancer cell expression of CD200 in tumor formation and metastasis, we generated CD200-positive and CD200-negative B16 melanoma cells. Subcutaneous injection of CD200-positive B16...

  20. Impact of CD200-Fc on dendritic cells in lupus-prone NZB/WF1 mice

    Science.gov (United States)

    Yin, Yufeng; Zhao, Lidan; Zhang, Fengchun; Zhang, Xuan

    2016-01-01

    Abnormal expression of CD200/CD200R1 may contribute to the immunologic abnormalities in patients with systemic lupus erythematosus (SLE). This study aimed to assess the function of CD200/CD200R1and impact of CD200-Fc on dendritic cells in lupus-prone NZB/WF1 mice. Female NZB/WF1 mice were treated with CD200-Fc or control for 4 weeks. Plasma samples were collected to measure autoantibody levels. The expression levels of CD200/CD200R1 in peripheral blood mononuclear cells (PBMCs) and splenocytes were examined. The percentage of CD200/CD200R1-positive cells in splenocytes from NZB/WF1 mice was lower than that of C57BL/6 mice (p lupus. PMID:27545083

  1. MiR-200c and HuR in ovarian cancer

    International Nuclear Information System (INIS)

    MicroRNAs in solid malignancies can behave as predictors of either good or poor outcome. This is the case with members of the miR-200 family, which are the primary regulators of the epithelial to mesenchymal transition and have been reported to act as both oncogenes and tumor suppressors. This study assessed the role of miR-200c as regulator of class III β-tubulin (TUBB3), a factor associated with drug-resistance and poor prognosis in ovarian cancer. Expression of miR-200c was assessed in a panel of ovarian cancer cell lines with inherent or acquired drug-resistance. Stable overexpression of miR-200c was obtained in A2780 and Hey cell lines. Crosslinking-coupled affinity purification method and ribonucleic-immunoprecipitation assay were used to characterise the complexes between miR-200c, HuR and 3′UTR region of TUBB3 mRNA. Nanofluidic technology and immunohistochemistry were used to analyze the expression of HuR, TUBB3 and miR-200c in 220 ovarian cancer patients. In a panel of ovarian adenocarcinoma cell lines, we observed a direct correlation between miR-200c expression and chemoresistance. In A2780 cells miR-200c targeted TUBB3 3′UTR, while a positive correlation was observed between miR-200c and TUBB3 expression in most of the other cell lines. Through the analysis of 3′UTR-associated complexes, we found that the miR-200c can increase the association of the RNA binding protein HuR with TUBB3 mRNA, whereas HuR binding enhanced TUBB3 mRNA translation. Most importantly, in our analysis on 220 ovarian cancer patients we observed that overexpression of miR-200c correlated with poor or good outcome depending on the cellular localization of HuR. This study suggests a model for the combined regulatory activity of miR-200c and HuR on TUBB3 expression in ovarian cancer. When HuR is nuclear, high expression of miR-200c inhibits TUBB3 expression and results in a good prognosis, whereas when HuR occurs in cytoplasm, the same miRNA enhances TUBB3 expression and

  2. The CD200 tolerance-signaling molecule and its receptor, CD200R1, are expressed in human placental villus trophoblast and in peri-implant decidua by 5 weeks' gestation.

    Science.gov (United States)

    Clark, David A; Arredondo, Jorge L; Dhesy-Thind, Sukhbinder

    2015-11-01

    CD200 expression in murine trophoblast and decidua prevents semi-allogeneic and LPS-induced abortions by binding to CD200 receptor-bearing cells to suppress NK activity, induces IDO in macrophages, and promotes the generation of regulatory T cell subsets. CD200 and its receptor CD200R1 reported in 7-9 weeks' gestation human villus trophoblasts are reduced in spontaneous abortion syncytiotrophoblasts. By specific antibody staining, we find that both CD200 and CD200R1 are expressed even earlier, by 5 weeks' gestation, by villus trophoblasts and by decidual cells. Expression of CD200 was validated using two independent antibodies. CD200-CD200R1 signaling may be required for human pregnancy success. PMID:26123445

  3. Design study of 1.8 K 200 W helium refrigeration system

    International Nuclear Information System (INIS)

    The superconducting RF cavities of the superconducting proton linac will be cooled by superfluid helium below 2.0 K. The cooling test of the superconducting RF cavities will be required about 200 W of cooling power at 1.8 K. Refrigeration using superfluid helium is required a helium refrigeration system cooling down to 1.8 K. A cold compressor is a key component for the system. IHI carried out 1.8 K 200 W helium refrigeration system design for cooling test of the superconducting RF cavities. The preliminary design study of the 1.8 K 200 W helium refrigeration system is presented. (author)

  4. 200-ZP-1 IRM phase 2 and 3 remedial design report, Revision 1

    International Nuclear Information System (INIS)

    This 200-ZP-1 remedial design report presents the objectives and rationale developed for the design and implementation of the selected interim remedial measure (IRM) for the 200-ZP-1 Operable Unit, located in the 200 West Area of the Hanford Site.The IRM was chosen in accordance with the Comprehensive Environmental Response, Compensation, and Liability Act of 1980, (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986, the Hanford Federal Facility Agreement and Consent Order (also known as the Tri- party Agreement), and the National Oil and Hazardous Substance Pollution Contingency Plan

  5. 200 Areas Remedial Investigation/Feasibility Study Implementation Plan - Environmental Restoration Program

    International Nuclear Information System (INIS)

    The 200 Areas Remedial Investigation/Feasibility Study Implementation Plan - Environmental Restoration Program (Implementation Plan) addresses approximately 700 soil waste sites (and associated structures such as pipelines) resulting from the discharge of liquids and solids from processing facilities to the ground (e.g., ponds, ditches, cribs,burial grounds) in the 200 Areas and assigned to the Environmental Restoration Program. The Implementation Plan outlines the framework for implementing assessment activities in the 200 Areas to ensure consistency in documentation, level of characterization, and decision making. The Implementation Plan also consolidates background information and other typical work plan materials, to serve as a single referenceable source for this type of information

  6. RCRA facility investigation report for the 200-PO-1 operable unit. Revision 1

    International Nuclear Information System (INIS)

    This Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI) report is prepared in support of the RFI/corrective measures study process for the 200-PO-1 Groundwater Operable Unit in the 200 East Area of the Hanford Site. This report summarizes existing information on this operable unit presented in the 200 East and PUREX Aggregate Area Management Study Reports, contaminant specific studies, available modeling data, and groundwater monitoring data summary reports. Existing contaminant data are screened against current regulatory limits to determine contaminants of potential concern (COPC). Each identified COPC is evaluated using well-specific and plume trend analyses

  7. Birth Defects Data from Surveillance Hospitals in Hubei Province, China, 200l – 2008

    OpenAIRE

    Jj Lin; Xd Li; Hp Zhang; Li, H; Lh Tu; Cl Xiong

    2012-01-01

    Background: To determine the prevalence and characteristics of birth defects in perinatal infants in Hubei Province during 200l-2008.Methods: The prevalence of birth defects in perinatal infants delivered after 28 weeks or more was analyzed in Hubei surveillance hospitals during 200l-2008.Results: The incidence of birth defects in perinatal infants from 200l to 2008 was 120.0 per 10,000 births, and was increased by about 41% from 81. 1 in 2001 to 138.5 per 10,000 births in 2008. The incidence...

  8. The Rhesus Rhadinovirus CD200 Homologue Affects Immune Responses and Viral Loads during In Vivo Infection

    OpenAIRE

    Estep, Ryan D.; Rawlings, Stephanie D.; Li, Helen; Manoharan, Minsha; Blaine, Elizabeth T.; O'Connor, Megan A.; Messaoudi, Ilhem; Axthelm, Michael K.; Wong, Scott W.

    2014-01-01

    Rhesus macaque rhadinovirus (RRV) is a gammaherpesvirus of rhesus macaque (RM) monkeys that is closely related to human herpesvirus 8 (HHV-8)/Kaposi's Sarcoma-associated herpesvirus (KSHV), and it is capable of inducing diseases in simian immunodeficiency virus (SIV)-infected RM that are similar to those seen in humans coinfected with HIV and HHV-8. Both HHV-8 and RRV encode viral CD200 (vCD200) molecules that are homologues of cellular CD200, a membrane glycoprotein that regulates immune res...

  9. USGS Small-scale Dataset - Color Hawaii Shaded Relief - 200-Meter Resolution 200512 GeoTIFF

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The NED...

  10. Zoning Districts, Published in 2009, 1:2400 (1in=200ft) scale, WABASH COUNTY GOVERNMENT.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Zoning Districts dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Hardcopy Maps information as of 2009. Data by this publisher...

  11. Zoning Districts, Published in 2009, 1:2400 (1in=200ft) scale, Dickinson County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Zoning Districts dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Published Reports/Deeds information as of 2009. Data by this...

  12. 16 CFR 20.0 - Scope and purpose of the guides.

    Science.gov (United States)

    2010-01-01

    ... Labeling Guides, 16 CFR part 228.) ... REBUILT, RECONDITIONED AND OTHER USED AUTOMOBILE PARTS INDUSTRY § 20.0 Scope and purpose of the guides... (including advertising in electronic format, such as on the Internet) of used parts and assemblies...

  13. The VASIMR[registered trademark] VF-200-1 ISS Experiment as a Laboratory for Astrophysics

    Science.gov (United States)

    Glover Tim W.; Squire, Jared P.; Longmier, Benjamin; Cassady, Leonard; Ilin, Andrew; Carter, Mark; Olsen, Chris S.; McCaskill, Greg; Diaz, Franklin Chang; Girimaji, Sharath; Araya, Daniel; Shebalin, John

    2010-01-01

    The VASIMR[R] Flight Experiment (VF-200-1) will be tested in space aboard the International Space Station (ISS) in about four years. It will consist of two 100 kW parallel plasma engines with opposite magnetic dipoles, resulting in a near zero-torque magnetic system. Electrical energy will come from ISS at low power level, be stored in batteries and used to fire the engine at 200 kW. The VF-200-1 project will provide a unique opportunity on the ISS National Laboratory for astrophysicists and space physicists to study the dynamic evolution of an expanding and reconnecting plasma loop. Here, we review the status of the project and discuss our current plans for computational modeling and in situ observation of a dynamic plasma loop on an experimental platform in low-Earth orbit. The VF-200-1 project is still in the early stages of development and we welcome new collaborators.

  14. Address Points, Published in 2008, 1:2400 (1in=200ft) scale, Meade County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Address Points dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Not Provided information as of 2008. The extent of these data...

  15. The Relationship between 200 m Performance and Selected Anthropometric Variables and Motor Abilities in Male Sprinters.

    Science.gov (United States)

    Maćkala, Krzysztof; Michalski, Ryszard; Čoh, Milan; Rausavljević, Nikola

    2015-07-01

    The goal of this study was the investigation of the relationship between 200 m performance and motor abilities and anthropometric characteristics of different level of male sprinters (200 m performance 23.80 ± 2.16 s--the best results 21.40 s). The physical fitness measures included: 50 m from standing and flying start, standing long jump (SLJ) standing five jump (SFJ), double and single leg countermovement jumps CMJ), flexibility (sit and reach) and 4 kg shot put throwing (over head). The Spearman correlation coefficient was applied to verify the association. The results demonstrated strong relationships (p motor abilities strong relationship exists between 200 m and time of 150 m, 50 m from standing and flying start and CMJ on single leg. Vertical jumping displayed stronger relationship with 200 m performance that horizontal one. From a practical point of view this is very important notice. PMID:26434013

  16. Dentist Offices, Published in 2008, 1:2400 (1in=200ft) scale, Shawano County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Dentist Offices dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Published Reports/Deeds information as of 2008. Data by this...

  17. Private Ambulance Services, Published in 2008, 1:2400 (1in=200ft) scale, Shawano County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Private Ambulance Services dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Published Reports/Deeds information as of 2008....

  18. Hospitals, Hospitals, Published in 2003, 1:2400 (1in=200ft) scale, Bibb County Government.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Hospitals dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Other information as of 2003. It is described as 'Hospitals'. Data...

  19. Zoning Districts, Published in 1990, 1:2400 (1in=200ft) scale, Kenosha County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Zoning Districts dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Published Reports/Deeds information as of 1990. Data by this...

  20. Doctor Offices, Published in 2008, 1:2400 (1in=200ft) scale, Shawano County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Doctor Offices dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Published Reports/Deeds information as of 2008. Data by this...

  1. Hydrography, Published in 2008, 1:2400 (1in=200ft) scale, Eau Claire County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Hydrography dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2008. Data by this publisher are...

  2. Railroad Lines, Published in 2008, 1:2400 (1in=200ft) scale, Eau Claire County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Railroad Lines dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Hardcopy Maps information as of 2008. Data by this publisher...

  3. Address Points, Published in 2008, 1:2400 (1in=200ft) scale, Eau Claire County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Address Points dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Other information as of 2008. Data by this publisher are often...

  4. Tourism Areas, Published in 2011, 1:2400 (1in=200ft) scale, Trempealeau County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Tourism Areas dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2011. Data by this publisher are...

  5. Contours, Published in 2004, 1:2400 (1in=200ft) scale, Transylvania County Assessor's Office.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Contours dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2004. Data by this publisher are often...

  6. Grayscale Hawaii Shaded Relief ? 200-Meter Resolution, Albers projection - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The...

  7. Recycling Facilities, Published in 2009, 1:2400 (1in=200ft) scale, City of Rome.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Recycling Facilities dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Other information as of 2009. Data by this publisher are...

  8. Hydrography, water, Published in 2005, 1:2400 (1in=200ft) scale, Marathon County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Hydrography dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2005. It is described as 'water'....

  9. Address Points, Published in 2013, 1:2400 (1in=200ft) scale, Oneida County Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Address Points dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Field Survey/GPS information as of 2013. Data by this publisher...

  10. 17 CFR 200.30-10 - Delegation of authority to Chief Administrative Law Judge.

    Science.gov (United States)

    2010-04-01

    ... Organization and Program Management General Organization § 200.30-10 Delegation of authority to Chief... subpenas requiring the production of documentary or other tangible evidence at any designated place...

  11. Public Access Points, Published in 2010, 1:2400 (1in=200ft) scale, Forsyth County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Public Access Points dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Field Observation information as of 2010. Data by this...

  12. Address Points, Published in 2008, 1:2400 (1in=200ft) scale, Kenosha County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Address Points dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Other information as of 2008. Data by this publisher are often...

  13. Grayscale Alaska Shaded Relief ? 200-Meter Resolution, Albers projection - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The...

  14. Color Hawaii Shaded Relief ? 200-Meter Resolution, Albers projection - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The NED...

  15. Color Alaska Shaded Relief ? 200-Meter Resolution, Albers projection - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The NED...

  16. Hydrography, rivers, Published in 2008, 1:2400 (1in=200ft) scale, Hamilton County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Hydrography dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Not Provided information as of 2008. It is described as 'rivers'....

  17. Address Points, Published in 2008, 1:2400 (1in=200ft) scale, Scott county.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Address Points dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Not Provided information as of 2008. Data by this publisher are...

  18. Contours, Published in 2006, 1:2400 (1in=200ft) scale, Kimley Horn and Associates.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Contours dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Field Survey/GPS information as of 2006. Data by this publisher are...

  19. USGS Small-scale Dataset - Grayscale Hawaii Shaded Relief - 200-Meter Resolution 200509 GeoTIFF

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The...

  20. USGS Small-scale Dataset - Grayscale Alaska Shaded Relief - 200-Meter Resolution 200509 GeoTIFF

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The...

  1. Public Beaches, Published in 2008, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Public Beaches dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2008. Data by this publisher are...

  2. Hospitals, Published in 2010, 1:2400 (1in=200ft) scale, City of Johns Creek.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Hospitals dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Field Observation information as of 2010. Data by this publisher are...

  3. ABB公司的A200-L涡轮增压器

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    ABB Turbocharging宣布,公司为二冲程低速发动机专门开发的新一代A200-L单段涡轮增压器,是涡轮增压器技术开发上的一个飞跃。A200-L的压缩机经过了优化,能够显著增加进气流量。

  4. Discrete Sampling Test Plan for the 200-BP-5 Operable Unit

    Energy Technology Data Exchange (ETDEWEB)

    Sweeney, Mark D.

    2010-02-04

    The Discrete Groundwater Sampling Project is conducted by the Pacific Northwest National Laboratory (PNNL) on behalf of CH2M HILL Plateau Remediation Company. The project is focused on delivering groundwater samples from proscribed horizons within select groundwater wells residing in the 200-BP-5 Operable Unit (200-BP-5 OU) on the Hanford Site. This document provides the scope, schedule, methodology, and other details of the PNNL discrete sampling effort.

  5. In situ Measurements of the SPS 200MHz Accelerating Cavity III

    CERN Document Server

    Kramer, Patrick; Caspers, Fritz; Vollinger, Christine; Montesinos, Eric; CERN. Geneva. ATS Department

    2015-01-01

    The main 200MHz travelling wave RF system of the SPS consists of two 5-tank and two 4-tank cavities. This system will be modified during LS 2, and the preparation work has already started. The 5 tank 200MHz travelling wave cavity III was measured in reflection. This Internal Note presents results obtained for the matching of cavity and feeder line, by looking at both frequency and time domain data. Techniques for estimating the feeder line attenuation are also presented.

  6. Depletion of CD200+ Hair Follicle Stem Cells in Human Prematurely Gray Hair Follicles

    OpenAIRE

    Sujata Mohanty; Anil Kumar; Jyoti Dhawan; Vinod K Sharma; Somesh Gupta

    2013-01-01

    Introduction: Melanocyte stem cells (MelSCs) are known to be depleted in gray hair follicles. Hair follicle stem cells (HFSCs) are important for maintenance of stemness of MelSCs. Methods: We compared the proportion of CD200+ (Cluster of Differentiation 200 positive) stem cells in the outer root sheath cell suspension of gray and pigmented hair follicles of three patients with the premature graying of hair. In addition, explants culture for HFSCs was also carried out from gray and pigmented h...

  7. Annex D-200 Area Interim Storage Area Final Safety Analysis Report [FSAR] [Section 1 & 2

    Energy Technology Data Exchange (ETDEWEB)

    CARRELL, R D

    2002-07-16

    The 200 Area Interim Storage Area (200 Area ISA) at the Hanford Site provides for the interim storage of non-defense reactor spent nuclear fuel (SNF) housed in aboveground dry cask storage systems. The 200 Area ISA is a relatively simple facility consisting of a boundary fence with gates, perimeter lighting, and concrete and gravel pads on which to place the dry storage casks. The fence supports safeguards and security and establishes a radiation protection buffer zone. The 200 Area ISA is nominally 200,000 ft{sup 2} and is located west of the Canister Storage Building (CSB). Interim storage at the 200 Area ISA is intended for a period of up to 40 years until the materials are shipped off-site to a disposal facility. This Final Safety Analysis Report (FSAR) does not address removal from storage or shipment from the 200 Area ISA. Three different SNF types contained in three different dry cask storage systems are to be stored at the 200 Area ISA, as follows: (1) Fast Flux Test Facility Fuel--Fifty-three interim storage casks (ISC), each holding a core component container (CCC), will be used to store the Fast Flux Test Facility (FFTF) SNF currently in the 400 Area. (2) Neutron Radiography Facility (NRF) TRIGA'--One Rad-Vault' container will store two DOT-6M3 containers and six NRF TRIGA casks currently stored in the 400 Area. (3) Commercial Light Water Reactor Fuel--Six International Standards Organization (ISO) containers, each holding a NAC-I cask4 with an inner commercial light water reactor (LWR) canister, will be used for commercial LWR SNF from the 300 Area. An aboveground dry cask storage location is necessary for the spent fuel because the current storage facilities are being shut down and deactivated. The spent fuel is being transferred to interim storage because there is no permanent repository storage currently available.

  8. Analysis of the role of p200-containing vesicles in post-Golgi traffic.

    OpenAIRE

    Ikonen, E.; Parton, R.G. (Robert G.); Lafont, F.; Simons, K

    1996-01-01

    p200 is a cytoplasmic protein that associates with vesicles budding from the trans-golgi network (TGN). The protein was identified by a monoclonal antibody AD7. We have used this antibody to analyze whether p200 functions in exocytic transport from the TGN to the apical or basolateral plasma membrane in Madin-Darby canine kidney cells. We found that transport of the viral marker proteins, influenza hemagglutinin (HA) to the apical surface or vesicular stomatitis virus glycoprotein (VSV G) to ...

  9. The reconstructed research reactor IRT-200 at service of bulgarian society

    International Nuclear Information System (INIS)

    In this report the possibility for using of reconstructed research reactor IRT-200 for purposes of the Boron Neutron Capture Therapy (BNCT) is discussed. A brief description of BNCT as well as main advantages of IRT-200, concerning infrastructure and neutron physical parameters are given. In the frame of the program for personnel training, a preliminary determination of dose distribution in depth for diseased and health brain tissues is done

  10. The novel fluid loss additive HTF-200C for oil field cementing%新型固井降失水剂HTF-200C

    Institute of Scientific and Technical Information of China (English)

    郭锦棠; 卢海川; 刘硕琼; 靳建州; 于永金

    2012-01-01

    The domestic fluid loss additives often have lower thermal stability and poor salt-tolerance and their comprehensive properties are not good enough. To solve the problems, a novel cement fluid loss additive HTF-200C. Which can resist high temperature and high salt content, was synthesized using the monomers of 2-acrylamido-2-methyl-propane sulphonic acid (AMPS), N, N-dimethyl acrylamide (DMAA) and a new compound with double carboxyl by the method of aqueous solution polymerization. The microstructural characterization and application performance of HTF-200C show that the polymer with the structure of all the monomers has an excellent thermal stability and strong salt tolerance, and can be used in 200 "C or in saturated brine. And the problem of the normal fluid loss additive being easy to hydrolyze due to high temperature can be solved with HTF-200C. What's more, it can also deal with the bulge of thickening curve in consistency test. The cement slurry prepared mainly by HTF-200C presents good comprehensive properties such as low filtration, high thermal stability, strong salt tolerance, rapid development of strength in low temperature, without far delayed solidification, short transit time during thickening process, and so on. The cementing job quality of Well Chengu 1-3 in the Liaohe Oilfield is excellent after it is used.%针对目前中国常规固井降失水剂抗温抗盐能力差、综合性能欠佳的问题,以2-丙烯酰胺基-2-甲基丙磺酸(AMPS)、N,N-二甲基丙烯酰胺(DMAA)、新型双羧基化合物为单体,采用水溶液自由基聚合的方法合成了耐盐、抗高温的共聚物型固井水泥降失水剂HTF-200C.HTF-200C微观结构表征和应用性能综合评价表明,各单体成功参与聚合,共聚物热稳定性良好;该降失水剂控失水耐温可达200℃,抗盐达饱和,可解决常规降失水剂高温下易水解、稠化实验“鼓包”等问题;以HTF-200C为主剂的水泥浆体系失水量低、抗盐耐温

  11. Epithelial cell differentiation regulated by MicroRNA-200a in mammary glands.

    Directory of Open Access Journals (Sweden)

    Kentaro Nagaoka

    Full Text Available Mammary gland epithelial cells undergo periodic cycles of proliferation, differentiation, and involution. Many studies have reported that miRNAs, which are small, non-coding RNAs, influence a variety of biological processes during posttranscriptional regulation. Here, we found that one miRNA, miR-200a, was relatively highly expressed in epithelial cell-rich organs such as mammary glands, lung, and kidney in mice. In mammary glands, miR-200a expression increased during mid-pregnancy through lactation; its expression was stimulated by lactogenic hormone treatment of mammary epithelial cells. Lactogenic hormone also induced the expression of milk protein ß-casein mRNA (a marker of cell differentiation and E-cadherin mRNA (a marker of epithelial cells. However, knockdown of miR-200a prevented increases in ß-casein and E-cadherin mRNA expression. Protein analysis revealed that E-cadherin signal was decreased and ZEB1 (a marker of EMT was increased following miR-200a knockdown. Finally, in a three-dimensional culture system modeling lumen-containing mammary ducts, miR-200a knockdown decreased the cavity formation rate and suppressed claudin-3 and par-6b expression, indicating reduced epithelial cell polarity. These observations suggest that miR-200a is important for maintaining the epithelial cell phenotype, which contributes to lactogenic hormone induction of cellular differentiation in mammary glands.

  12. Analysis of 200 Cases of Pathological Pregnancy of Advanced Maternal Age%高龄产妇200例病理妊娠分析

    Institute of Scientific and Technical Information of China (English)

    侯玉琼

    2013-01-01

    目的 通过实验讨论研究高龄产妇的病理性妊娠产生时的状况.方法将高龄孕妇200例和年龄<35岁产妇200例配合搭对两组妊娠发生状况.结果高龄孕妇组妊娠期间患有高血压等几率显著大于对照组.结论高龄产妇病理妊娠产生机会比率大,应强化高龄产妇期间护理.

  13. On the Structure and Maintenance of XHX200 X-ray Machine%XHX200型X光机结构分析及保养技巧

    Institute of Scientific and Technical Information of China (English)

    张日文

    2015-01-01

    This paper analyzed the actual structure of XHX200 medical X-ray machine systematicaly. Based on the working experience of many years, the author also put forward some maintenance tips during instalation, use and cleaning, which can facilitate the machine’s safe operation and life extension.%本文系统分析了X H X200型医用X光机的实际结构,并根据多年工作经验从安装、使用及清洁等环节提出有利于设备安全运行和使用寿命延长的保养技巧。

  14. On the Structure and Maintenance of XHX200 X-ray Machine%XHX200型X光机结构分析及保养技巧

    Institute of Scientific and Technical Information of China (English)

    张日文

    2014-01-01

    本文系统分析了XHX200型医用X光机的实际结构,并根据多年工作经验从安装、使用及清洁等环节提出有利于设备安全运行和使用寿命延长的保养技巧。%This paper analyzed the actual structure of XHX200 medical X-ray machine systematical y.Based on the working experience of many years, the author also put forward some maintenance tips during instal ation,use and cleaning, which can facilitate the machine's safe operation and life extension.

  15. FEASIBILITY STUDY REPORT FOR THE 200-ZP-1 GROUNDWATER OPERABLE UNIT

    Energy Technology Data Exchange (ETDEWEB)

    BYRNES ME

    2008-07-18

    The Hanford Site, managed by the U.S. Department of Energy (DOE), encompasses approximately 1,517 km{sup 2} (586 mi{sup 2}) in the Columbia Basin of south-central Washington State. In 1989, the U.S. Environmental Protection Agency (EPA) placed the 100, 200, 300, and 1100 Areas of the Hanford Site on the 40 Code of Federal Regulations (CFR) 300, 'National Oil and Hazardous Substances Pollution Contingency Plan' National Contingency Plan [NCPD], Appendix B, 'National Priorities List' (NPL), pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The 200 Areas NPL sites consist of the 200 West and 200 East Areas (Figure 1-1). The 200 Areas contain waste management facilities, inactive irradiated fuel reprocessing facilities, and the 200 North Area (formerly used for interim storage and staging of irradiated fuel). Several waste sites in the 600 Area, located near the 200 Areas, also are included in the 200 Areas NPL site. The 200 Areas NPL site is in a region referred to as the 'Central Plateau' and consists of approximately 700 waste sites, excluding sites assigned to the tank farm waste management areas (WMAs). The 200-ZP-1 Groundwater Operable Unit (OU) consists of the groundwater located under the northern portion of the 200 West Area. Waste sources that contributed to the 200-ZP-1 OU included cribs and trenches that received liquid and/or solid waste in the past from the Z Plant and T Plant aggregate areas, WMA-T, WMA-TX/TY, and the State-Approved Land Disposal Site (SALDS). This feasibility study (FS) for the 200-ZP-1 Groundwater OU was prepared in accordance with the requirements of CERCLA decision documents. These decision documents are part of the Administrative Record for the selection of remedial actions for each waste site and present the selected remedial actions that are chosen in accordance with CERCLA, as amended by the Superfund Amendments and Reauthorization Act of 1986

  16. Spatial Analysis of Contaminants in 200 West Area Groundwater in Support of the 200-ZP-1 Operable Unit Pre-Conceptual Remedy Design

    Energy Technology Data Exchange (ETDEWEB)

    Murray, Christopher J.; Bott, Yi-Ju

    2008-12-30

    This report documents a preliminary spatial and geostatistical analysis of the distribution of several contaminants of interest (COIs) in groundwater within the unconfined aquifer beneath the 200 West Area of the Hanford Site. The contaminant plumes of interest extend within the 200-ZP-1 and 200-UP-1 groundwater operable units. The COIs included in the PNNL study were carbon tetrachloride (CTET), technetium-99 (Tc-99), iodine-129 (I-129), chloroform, plutonium, uranium, trichloroethylene (TCE), and nitrate. The project included three tasks. Task 1 involved the development of a database that includes all relevant depth-discrete data on the distribution of COIs in the study area. The second task involved a spatial analysis of the three-dimensional (3D) distribution of data for the COIs in the study area. The main focus of the task was to determine if sufficient data are available for geostatistical mapping of the COIs in 3D. Task 3 involved the generation of numerical grids of the concentration of CTET, chloroform, and Tc-99.

  17. Historical records of radioactive contamination in biota at the 200 Areas of the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, A.R.; Markes, B.M.; Schmidt, J.W.; Shah, A.N.; Weiss, S.G.; Wilson, K.J.

    1994-06-01

    This document summarizes and reports a literature search of 85 environmental monitoring records of wildlife and vegetation (biota) at the 200 East Area and the 200 West Area of the Hanford Site since 1965. These records were published annually and provided the majority of the data in this report. Additional sources of data have included records of specific facilities, such as site characterization documents and preoperational environmental surveys. These documents have been released for public use. Records before 1965 were still being researched and therefore not included in this document. The intent of compiling these data into a single source was to identify past and current concentrations of radionuclides in biota at specific facilities and waste sites within each operable unit that may be used to help guide cleanup activities in the 200 Areas to be completed under the Comprehensive Environmental Response and Liability Act (CERCLA). The 200 East Area and 200 West Area were the locations of the Hanford Site separation and process facilities and waste management units. For the purposes of this document, a sample was of interest if a Geiger-Mueller counter equipped with a pancake probe-indicated beta/gamma emitting radioactivity above 200 counts per minute (cpm), or if laboratory radioanalyses indicated a radionuclide concentration equaled or exceeded 10 picocuries per gram (pCi/g). About 4,500 individual cases of monitoring for radionuclide uptake or transport in biota in the 200 Areas environs were included in the documents reviewed. About 1,900 (i.e., 42%) of these biota had radionuclide concentrations in excess of 10 pCi/g. These radionuclide transport or uptake cases were distributed among 45 species of wildlife (primarily small mammals and feces) and 30 species of vegetation. The wildlife species most commonly associated with radioactive contamination were the house mouse and the deer mouse and of vegetation species, the Russian thistle.

  18. Circulating microRNA-200 Family as Diagnostic Marker in Hepatocellular Carcinoma.

    Directory of Open Access Journals (Sweden)

    Sameer A Dhayat

    Full Text Available In this clinical study, we aimed to evaluate the role of circulating microRNA-200 family as a non-invasive tool to identify patients with cirrhosis-associated hepatocellular carcinoma (HCC.Prognosis of HCC remains poor with increasing incidence worldwide, mainly related to liver cirrhosis. So far, no reliable molecular targets exist for early detection of HCC at surgically manageable stages. Recently, we identified members of the microRNA-200 family as potential diagnostic markers of cirrhosis-associated HCC in patient tissue samples. Their value as circulating biomarkers for HCC remained undefined.Blood samples and clinicopathological data of consecutive patients with liver diseases were collected prospectively. Expression of the microRNA-200 family was investigated by qRT-PCR in blood serum samples of 22 HCC patients with and without cirrhosis. Serum samples of patients with non-cancerous chronic liver cirrhosis (n = 22 and of healthy volunteers (n = 15 served as controls.MicroRNA-141 and microRNA-200a were significantly downregulated in blood serum of patients with HCC compared to liver cirrhosis (p<0.007 and healthy controls (p<0.002. MicroRNA-141 and microRNA-200a could well discriminate patients with cirrhosis-associated HCC from healthy volunteers with area under the receiver-operating characteristic curve (AUC values of 0.85 and 0.82, respectively. Additionally, both microRNAs could differentiate between HCC and non-cancerous liver cirrhosis with a fair accuracy.Circulating microRNA-200 family members are significantly deregulated in patients with HCC and liver cirrhosis. Further studies are necessary to confirm the diagnostic value of the microRNA-200 family as accurate serum marker for cirrhosis-associated HCC.

  19. Historical records of radioactive contamination in biota at the 200 Areas of the Hanford Site

    International Nuclear Information System (INIS)

    This document summarizes and reports a literature search of 85 environmental monitoring records of wildlife and vegetation (biota) at the 200 East Area and the 200 West Area of the Hanford Site since 1965. These records were published annually and provided the majority of the data in this report. Additional sources of data have included records of specific facilities, such as site characterization documents and preoperational environmental surveys. These documents have been released for public use. Records before 1965 were still being researched and therefore not included in this document. The intent of compiling these data into a single source was to identify past and current concentrations of radionuclides in biota at specific facilities and waste sites within each operable unit that may be used to help guide cleanup activities in the 200 Areas to be completed under the Comprehensive Environmental Response and Liability Act (CERCLA). The 200 East Area and 200 West Area were the locations of the Hanford Site separation and process facilities and waste management units. For the purposes of this document, a sample was of interest if a Geiger-Mueller counter equipped with a pancake probe-indicated beta/gamma emitting radioactivity above 200 counts per minute (cpm), or if laboratory radioanalyses indicated a radionuclide concentration equaled or exceeded 10 picocuries per gram (pCi/g). About 4,500 individual cases of monitoring for radionuclide uptake or transport in biota in the 200 Areas environs were included in the documents reviewed. About 1,900 (i.e., 42%) of these biota had radionuclide concentrations in excess of 10 pCi/g. These radionuclide transport or uptake cases were distributed among 45 species of wildlife (primarily small mammals and feces) and 30 species of vegetation. The wildlife species most commonly associated with radioactive contamination were the house mouse and the deer mouse and of vegetation species, the Russian thistle

  20. Nanoparticle-mediated miR200-b delivery for the treatment of diabetic retinopathy.

    Science.gov (United States)

    Mitra, Rajendra Narayan; Nichols, Chance A; Guo, Junjing; Makkia, Rasha; Cooper, Mark J; Naash, Muna I; Han, Zongchao

    2016-08-28

    We recently reported that the Ins2(Akita) mouse is a good model for late-onset diabetic retinopathy. Here, we investigated the effect of miR200-b, a potential anti-angiogenic factor, on VEGF receptor 2 (VEGFR-2) expression and to determine the underlying angiogenic response in mouse endothelial cells, and in retinas from aged Ins2(Akita) mice. MiR200-b and its native flanking sequences were amplified and cloned into a pCAG-eGFP vector directed by the ubiquitous CAG promoter (namely pCAG-miR200-b-IRES-eGFP). The plasmid was compacted by CK30PEG10K into DNA nanoparticles (NPs) for in vivo delivery. Murine endothelial cell line, SVEC4-10, was first transfected with the plasmid. The mRNA levels of VEGF and VEGFR-2 were quantified by qRT-PCR and showed significant reduction in message expression compared with lipofectamine-transfected cells. Transfection of miR200-b suppressed the migration of SVEC4-10 cells. There was a significant inverse correlation between the level of expression of miR200-b and VEGFR-2. Intravitreal injection of miR200-b DNA NPs significantly reduced protein levels of VEGFR-2 as revealed by western blot and markedly suppressed angiogenesis as evaluated by fundus imaging in aged Ins2(Akita) mice even after 3months of post-injection. These findings suggest that NP-mediated miR200-b delivery has negatively regulated VEGFR-2 expression in vivo. PMID:27297781

  1. Phase 1 remedial investigation report for 200-BP-1 operable unit

    International Nuclear Information System (INIS)

    The US Department of Energy (DOE) Hanford Site, in Washington State is organized into numerically designated operational areas including the 100, 200, 300, 400, 600, and 1100 Areas. The US Environmental Protection Agency (EPA), in November 1989 included the 200 Areas of the Hanford Site on the National Priority List (NPL) under the Comprehensive Environmental Response, Compensation and Liability Act of 1980 (CERCLA). Inclusion on the NPL initiated the remedial investigation (RD process for the 200-BP-1 operable unit. These efforts are being addressed through the Hanford Federal Facility Agreement and Consent Order (Ecology et al. 1989) which was negotiated and approved by the DOE, the EPA, and the State of Washington Department of Ecology (Ecology) in May 1989. This agreement, known as the Tri-Party Agreement, governs all CERCLA efforts at Hanford. In March of 1990, the Department of Energy, Richland Operations (DOE-RL) issued a Remedial Investigation/Feasibility Study (RI/FS) work plan (DOE-RL 1990a) for the 200-BP-1 operable unit. The work plan initiated the first phase of site characterization activities associated with the 200-BP-1 operable unit. The purpose of the 200-BP-1 operable unit RI is to gather and develop the necessary information to adequately understand the risks to human health and the environment posed by the site and to support the development and analysis of remedial alternatives during the FS. The RI analysis will, in turn, be used by Tri-Party Agreement signatories to make a risk-management-based selection of remedies for the releases of hazardous substances that have occurred from the 200-BP-1 operable unit

  2. Phase 1 remedial investigation report for 200-BP-1 operable unit. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    The US Department of Energy (DOE) Hanford Site, in Washington State is organized into numerically designated operational areas including the 100, 200, 300, 400, 600, and 1100 Areas. The US Environmental Protection Agency (EPA), in November 1989 included the 200 Areas of the Hanford Site on the National Priority List (NPL) under the Comprehensive Environmental Response, Compensation and Liability Act of 1980 (CERCLA). Inclusion on the NPL initiated the remedial investigation (RD process for the 200-BP-1 operable unit. These efforts are being addressed through the Hanford Federal Facility Agreement and Consent Order (Ecology et al. 1989) which was negotiated and approved by the DOE, the EPA, and the State of Washington Department of Ecology (Ecology) in May 1989. This agreement, known as the Tri-Party Agreement, governs all CERCLA efforts at Hanford. In March of 1990, the Department of Energy, Richland Operations (DOE-RL) issued a Remedial Investigation/Feasibility Study (RI/FS) work plan (DOE-RL 1990a) for the 200-BP-1 operable unit. The work plan initiated the first phase of site characterization activities associated with the 200-BP-1 operable unit. The purpose of the 200-BP-1 operable unit RI is to gather and develop the necessary information to adequately understand the risks to human health and the environment posed by the site and to support the development and analysis of remedial alternatives during the FS. The RI analysis will, in turn, be used by Tri-Party Agreement signatories to make a risk-management-based selection of remedies for the releases of hazardous substances that have occurred from the 200-BP-1 operable unit.

  3. FEASIBILITY STUDY REPORT FOR THE 200-ZP-1 GROUNDWATER OPERABLE UNIT

    Energy Technology Data Exchange (ETDEWEB)

    BYRNES ME

    2008-07-18

    The Hanford Site, managed by the U.S. Department of Energy (DOE), encompasses approximately 1,517 km{sup 2} (586 mi{sup 2}) in the Columbia Basin of south-central Washington State. In 1989, the U.S. Environmental Protection Agency (EPA) placed the 100, 200, 300, and 1100 Areas of the Hanford Site on the 40 Code of Federal Regulations (CFR) 300, 'National Oil and Hazardous Substances Pollution Contingency Plan' National Contingency Plan [NCPD], Appendix B, 'National Priorities List' (NPL), pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The 200 Areas NPL sites consist of the 200 West and 200 East Areas (Figure 1-1). The 200 Areas contain waste management facilities, inactive irradiated fuel reprocessing facilities, and the 200 North Area (formerly used for interim storage and staging of irradiated fuel). Several waste sites in the 600 Area, located near the 200 Areas, also are included in the 200 Areas NPL site. The 200 Areas NPL site is in a region referred to as the 'Central Plateau' and consists of approximately 700 waste sites, excluding sites assigned to the tank farm waste management areas (WMAs). The 200-ZP-1 Groundwater Operable Unit (OU) consists of the groundwater located under the northern portion of the 200 West Area. Waste sources that contributed to the 200-ZP-1 OU included cribs and trenches that received liquid and/or solid waste in the past from the Z Plant and T Plant aggregate areas, WMA-T, WMA-TX/TY, and the State-Approved Land Disposal Site (SALDS). This feasibility study (FS) for the 200-ZP-1 Groundwater OU was prepared in accordance with the requirements of CERCLA decision documents. These decision documents are part of the Administrative Record for the selection of remedial actions for each waste site and present the selected remedial actions that are chosen in accordance with CERCLA, as amended by the Superfund Amendments and Reauthorization Act of 1986

  4. Functional Analysis of the Short Isoform of Orf Virus Protein OV20.0

    Science.gov (United States)

    Tseng, Yeu-Yang; Lin, Fong-Yuan; Cheng, Sun-Fang; Chulakasian, Songkhla; Chou, Chia-Chi; Liu, Ya-Fen; Chang, Wei-Shan; Wong, Min-Liang

    2015-01-01

    ABSTRACT Orf virus (ORFV) OV20.0L is an ortholog of vaccinia virus (VACV) gene E3L. The function of VACV E3 protein as a virulence factor is well studied, but OV20.0 has received less attention. Here we show that like VACV E3L, OV20.0L encodes two proteins, a full-length protein and a shorter form (sh20). The shorter sh20 is an N-terminally truncated OV20.0 isoform generated when a downstream AUG codon is used for initiating translation. These isoforms differed in cellular localization, with full-length OV20.0 and sh20 found throughout the cell and predominantly in the cytoplasm, respectively. Nonetheless, both OV20.0 isoforms were able to bind double-stranded RNA (dsRNA)-activated protein kinase (PKR) and dsRNA. Moreover, both isoforms strongly inhibited PKR activation as shown by decreased phosphorylation of the translation initiation factor eIF2α subunit and protection of Sindbis virus infection against the activity of interferon (IFN). In spite of this apparent conservation of function in vitro, a recombinant ORFV that was able to express only the sh20 isoform was attenuated in a mouse model. IMPORTANCE The OV20.0 protein of orf virus (ORFV) has two isoforms and contributes to virulence, but the roles of the two forms are not known. This study shows that the shorter isoform (sh20) arises due to use of a downstream initiation codon and is amino-terminally truncated. The sh20 form also differs in expression kinetics and cellular localization from full-length OV20.0. Similar to the full-length isoform, sh20 is able to bind dsRNA and PKR, inactivate PKR, and thus act as an antagonist of the interferon response in vitro. In vivo, however, wild-type OV20.0 could not be replaced with sh20 alone without a loss of virulence, suggesting that the functions of the isoforms are not simply redundant. PMID:25694596

  5. MicroRNA-200 Family Profile: A Promising Ancillary Tool for Accurate Cancer Diagnosis.

    Science.gov (United States)

    Liu, Xiaodong; Zhang, Jianhua; Xie, Botao; Li, Hao; Shen, Jihong; Chen, Jianheng

    2016-01-01

    Cancer is one of the most threatening diseases in the world and great interests have been paid to discover accurate and noninvasive methods for cancer diagnosis. The value of microRNA-200 (miRNA-200, miR-200) family has been revealed in many studies. However, the results from various studies were inconsistent, and thus a meta-analysis was designed and performed to assess the overall value of miRNA200 in cancer diagnosis. Relevant studies were searched electronically from the following databases: PubMed, Embase, Web of Science, the Cochrane Library, and Chinese National Knowledge Infrastructure. Keyword combined with "miR-200," "cancer," and "diagnosis" in any fields was used for searching relevant studies. Then, the pooled sensitivity, specificity, area under the curve (AUC), and partial AUC were calculated using the random-effects model. Heterogeneity among individual studies was also explored by subgroup analyses. A total of 28 studies from 18 articles with an overall sample size of 3676 subjects (2097 patients and 1579 controls) were included in this meta-analysis. The overall sensitivity and specificity with 95% confidence intervals (95% CIs) are 0.709 (95% CI: 0.657-0.755) and 0.667 (95% CI: 0.617-0.713), respectively. Additionally, AUC and partial AUC for the pooled data is 0.735 and 0.627, respectively. Subgroup analyses revealed that using miRNA-200 family for cancer diagnosis is more effective in white than in Asian ethnic groups. In addition, cancer diagnosis by miRNA using circulating specimen is more effective than that using noncirculating specimen. Finally, miRNA is more accurate in diagnosing endometrial cancer than other types of cancer, and some miRNA family members (miR-200b and miR-429) have superior diagnostic accuracy than other miR-200 family members. In conclusion, the profiling of miRNA-200 family is likely to be a valuable tool in cancer detection and diagnosis. PMID:26618619

  6. Conceptual design report, 200 Area sanitary sewer system: Project 96L-EWL-116

    International Nuclear Information System (INIS)

    Project L-116 will install an integrated sanitary sewer system in the 200 Area. This new system will connect existing sewer systems for facilities that have a foreseeable future, provide capacity and routing for future facilities, and install new septic sewer systems for existing facilities that cannot be feasibly connected to the new sewer system and have a mission that will extend beyond the year 2000. Project L-116 will construct a sanitary sewer collection, treatment, and disposal system for facilities in the 200-East and -West Areas and adjacent areas located on the 200 Area plateau. The existing septic systems will be abandoned or decommissioned in accordance with applicable Washington State and local codes and regulations. The conceptual design for the sanitary sewer system is designed around population forecasts of 5,000 people for 200-West Area and 9,000 people for 200-East Area. The definitive design will be based on the latest forecast populations at the time definitive design is initiated

  7. 20 CFR 25.200 - How is the Special Schedule applied for employees in the Republic of the Philippines?

    Science.gov (United States)

    2010-04-01

    ... employees in the Republic of the Philippines? 25.200 Section 25.200 Employees' Benefits OFFICE OF WORKERS... Compensation § 25.200 How is the Special Schedule applied for employees in the Republic of the Philippines? (a.... Military Forces covered by the Philippine Medical Care Program and the Employees' Compensation...

  8. 41 CFR 102-73.200 - What types of special purpose space may the Department of the Interior lease?

    Science.gov (United States)

    2010-07-01

    ... purpose space may the Department of the Interior lease? 102-73.200 Section 102-73.200 Public Contracts and... § 102-73.200 What types of special purpose space may the Department of the Interior lease? The Department of the Interior is delegated authority to lease the following types of special purpose space:...

  9. Cherenkov counter of extensive air showers for combined operation with the neutrino telescope NT-200

    International Nuclear Information System (INIS)

    The Baikal NT-200 neutrino telescope consists of 192 optical modules based on the Quasar-370 hybrid photodetectors. To study the angular resolution of NT-200 neutrino telescope one has developed the Cherenkov counter of extensive air showers with 1 deg angular resolution. Paper describes the electron structure of the facility made in terms of the CAMAC standard. One evaluates the measurement error for time intervals depending on the amplitude of output signals of photodetector. The counting rate of coinciding events of the Cherenkov counter for extensive air showers and of NT-200 deep-sea neutrino telescope constitutes about 0.5 min-1.Measuring of time interval between the trigger signals of the neutrino telescope and of the Cherenkov counter enables to suppress efficiently random coincidences and to obtain additional information on the muon trajectory

  10. The IS200/IS605 Family and "Peel and Paste" Single-strand Transposition Mechanism.

    Science.gov (United States)

    He, S; Corneloup, A; Guynet, C; Lavatine, L; Caumont-Sarcos, A; Siguier, P; Marty, B; Dyda, F; Chandler, M; Ton Hoang, B

    2015-08-01

    This chapter presents an analysis of the organization and distribution of the IS200/IS605 family of insertion sequences (IS). Members of this family are widespread in both bacteria and archaea. They are unusual because they use obligatory single-strand DNA intermediates, which distinguishes them from classical IS. We summarize studies of the experimental model systems IS608 (from Helicobacter pylori) and ISDra2 (from Deinococcus radiodurans) and present biochemical, genetic, and structural data that describe their transposition pathway and the way in which their transposase (an HuH rather than a DDE enzyme) catalyzes this process. The transposition of IS200/IS605 family members can be described as a "Peel-and-Paste" mechanism. We also address the probable domestication of IS200/IS605 family transposases as enzymes involved in multiplication of repeated extragenic palindromes and as potential homing endonucleases in intron-IS chimeras. PMID:26350330

  11. Continuous pulse oximetry in the general surgical ward: Nellcor N-200 versus Nellcor N-3000

    DEFF Research Database (Denmark)

    Christensen, M; Lie, C; Rosenberg, J

    1999-01-01

    New measurement principles in pulse oximetry have been introduced to decrease the incidence of false movement alarms. Experimental studies have shown that the new Nellcor Symphony N-3000 may reduce the incidence of false alarms when monitoring during different activities. We compared the Nellcor...... Symphony N-3000 with the Nellcor N-200 pulse oximeter, when monitoring patients in the general surgical ward. Twenty-two patients were monitored during unrestricted ward activities for a total of 275 h with a N-3000 and a N-200 pulse oximeter simultaneously. Data were analysed for lack of concordance...... between the two pulse oximeters with respect to frequency of registered hypoxaemic episodes and thus the amount of time spent in the alarm state. The median number of desaturation episodes with the N-200 was 18 (range 0-511) compared with four (range 0-476) with the N-3000 (p < 0.0001). The median number...

  12. Dry-type 50 MW, 200 kV Tesla transformer for compact pulse generator

    International Nuclear Information System (INIS)

    Full text: A 15V/200kV, 2μs air-core pulse transformer has been designed and fabricated for a prototype compact pulse generator for generation of intense pulsed electron beams. The transformer can deliver 50 to 100J energy at 50 MW peak power to charge a pulse forming line at 200 kV in 2μs time, which on discharge produces 200kV, 50ns HV pulse. This pulse transformer has also been used for surface flashover studies on insulators in vacuum and transformer oil mediums for sub-micro second region. In this paper, design details of pulse transformer, the test results and a comparative discussion with the conventional systems has been presented in brief

  13. Elastic scattering of polarised deuterons from 16O at 200, 400 and 700 MeV

    International Nuclear Information System (INIS)

    Angular distributions of cross section, and Ay and Ayy analysing powers were measured for polarised deuteron elastic scattering from 16O at 200, 400 and 700 MeV. The data at 200 MeV bear evidence of the nuclear rainbow phenomenon while those at 400 and 700 MeV are reminiscent of the proton scattering results at equivalent energies. The data were analysed in terms of the optical model. The real central potential shape changes from an attractive Woods-Saxon form at 200 MeV to a wine-bottle-bottom form with a repulsive interior at 700 MeV. The total reaction cross sections deduced display a clear nuclear transparency effect in the present energy domain in agreement with predictions from the Glauber theory optical limit. Comparison with previous results for 40Ca and 58Ni targets is made. (orig.)

  14. Elastic scattering of polarised deuterons from 16O at 200, 400 and 700 MeV

    International Nuclear Information System (INIS)

    Angular distributions of cross section, and Ay and Ayy analysing powers were measured for polarised deuteron elastic scattering from 16O at 200, 400 and 700 MeV. The data at 200 MeV bear evidence of the nuclear rainbow phenomenon while those at 400 and 700 MeV are reminiscent of the proton scattering results at equivalent energies. The data were analysed in terms of the optical model. The real central potential shape changes from an attractive Woods-Saxon form at 200 MeV to a wine-bottle-bottom form with a repulsive interior at 700 Mev. The total reaction cross sections deduced display a clear nuclear transparency effect in the present energy domain agreement with predictions from the Glauber theory optical limit. Comparison with previous results for 40Ca and 58Ni targets is made

  15. Qualification tests for the low sulfur expanded graphite product Cefigraf NAC S200

    International Nuclear Information System (INIS)

    Previously qualified expanded graphites used to make stuffing box or seal packing are no compliant with all PMUC requirements in the following respects: - chemical: limited halogen and sulfur contents (less than 200 ppm); - technical : positive functionability tests; - quality assurance : manufacturers or suppliers compliant with AREN 29002; - commercial : national outline-agreements between EDF and the manufacturers. EDF/R and DD is responsible for functionability tests in the PMUC organization. This paper reports the tests performed with a low sulfur expanded graphite tape from LE CARBONE LORRAINE - CEFILAC ET ETANCHEITE, referenced CEFIGRAF NAC S200. As the basic product was new, we observed the behavior of stuffing box packing made with it, regarding: - mechanical strength (using a press); - corrosion at ambient temperature on eight steel grades; - leaktightness at 200 bar and 300 deg C in demineralized water; - cycling life span. Results obtained are satisfactory and comparable to those for previously qualified expanded graphites. (authors). 1 fig., 1 tab., 3 refs., 3 annexes

  16. Melanoma cell expression of CD200 inhibits tumor formation and lung metastasis via inhibition of myeloid cell functions.

    Directory of Open Access Journals (Sweden)

    Fatemeh Talebian

    Full Text Available CD200 is a cell surface glycoprotein that functions through engaging CD200 receptor on cells of the myeloid lineage and inhibits their functions. Expression of CD200 has been implicated in a variety of human cancer cells including melanoma cells and has been thought to play a protumor role. To investigate the role of cancer cell expression of CD200 in tumor formation and metastasis, we generated CD200-positive and CD200-negative B16 melanoma cells. Subcutaneous injection of CD200-positive B16 melanoma cells inhibited tumor formation and growth in C57BL/6 mice but not in Rag1⁻/⁻C57BL/6 mice. However, i.v. injection of CD200-positive B16 melanoma cells dramatically inhibited tumor foci formation in the lungs of both C57BL/6 and Rag1⁻/⁻C57BL6 mice. Flow cytometry analysis revealed higher expression of CD200R in Gr1⁺ myeloid cells in the lung than in peripheral myeloid cells. Depletion of Gr1⁺ cells or stimulation of CD200R with an agonistic antibody in vivo dramatically inhibited tumor foci formation in the lungs. In addition, treatment with tumor antigen specific CD4 or CD8 T cells or their combination yielded a survival advantage for CD200 positive tumor bearing mice over mice bearing CD200-negative tumors. Taken together, we have revealed a novel role for CD200-CD200R interaction in inhibiting tumor formation and metastasis. Targeting CD200R may represent a novel approach for cancer immunotherapy.

  17. Pilot-scale treatability test plan for the 200-BP-5 operable unit

    International Nuclear Information System (INIS)

    This document presents the treatability test plan for pilot-scale pump and treat testing at the 200-BP-5 Operable Unit. This treatability test plan has been prepared in response to an agreement between the U.S. Department of Energy (DOE), the U.S. Environmental Protection Agency (EPA), and the State of Washington Department of Ecology (Ecology), as documented in Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement, Ecology et al. 1989a) Change Control Form M-13-93-03 (Ecology et al. 1994) and a recent 200 NPL Agreement Change Control Form (Appendix A). The agreement also requires that, following completion of the activities described in this test plan, a 200-BP-5 Operable Unit Interim Remedial Measure (IRM) Proposed Plan be developed for use in preparing an Interim Action Record of Decision (ROD). The IRM Proposed Plan will be supported by the results of this treatability test plan, as well as by other 200-BP-5 Operable Unit activities (e.g., development of a qualitative risk assessment). Once issued, the Interim Action ROD will specify the interim action(s) for groundwater contamination at the 200-BP-5 Operable Unit. The treatability test approach is to conduct a pilot-scale pump and treat test for each of the two contaminant plumes associated with the 200-BP-5 Operable Unit. Primary contaminants of concern are 99Tc and 60Co for underwater affected by past discharges to the 216-BY Cribs, and 90Sr, 239/240Pu, and Cs for groundwater affected by past discharges to the 216-B-5 Reverse Well. The purpose of the pilot-scale treatability testing presented in this testplan is to provide the data basis for preparing an IRM Proposed Plan. To achieve this objective, treatability testing must: Assess the performance of groundwater pumping with respect to the ability to extract a significant amount of the primary contaminant mass present in the two contaminant plumes

  18. Development of the CCP-200 mathematical model for Syzran CHPP using the Thermolib software package

    Science.gov (United States)

    Usov, S. V.; Kudinov, A. A.

    2016-04-01

    Simplified cycle diagram of the CCP-200 power generating unit of Syzran CHPP containing two gas turbines PG6111FA with generators, two steam recovery boilers KUP-110/15-8.0/0.7-540/200, and one steam turbine Siemens SST-600 (one-cylinder with two variable heat extraction units of 60/75 MW in heatextraction and condensing modes, accordingly) with S-GEN5-100 generators was presented. Results of experimental guarantee tests of the CCP-200 steam-gas unit are given. Brief description of the Thermolib application for the MatLab Simulink software package is given. Basic equations used in Thermolib for modeling thermo-technical processes are given. Mathematical models of gas-turbine plant, heat-recovery steam generator, steam turbine and integrated plant for power generating unit CCP-200 of Syzran CHPP were developed with the help of MatLab Simulink and Thermolib. The simulation technique at different ambient temperature values was used in order to get characteristics of the developed mathematical model. Graphic comparison of some characteristics of the CCP-200 simulation model (gas temperature behind gas turbine, gas turbine and combined cycle plant capacity, high and low pressure steam consumption and feed water consumption for high and low pressure economizers) with actual characteristics of the steam-gas unit received at experimental (field) guarantee tests at different ambient temperature are shown. It is shown that the chosen degrees of complexity, characteristics of the CCP-200 simulation model, developed by Thermolib, adequately correspond to the actual characteristics of the steam-gas unit received at experimental (field) guarantee tests; this allows considering the developed mathematical model as adequate and acceptable it for further work.

  19. Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer

    Directory of Open Access Journals (Sweden)

    Kan Casina WS

    2012-12-01

    Full Text Available Abstract Background There is a critical need for improved diagnostic markers for high grade serous epithelial ovarian cancer (SEOC. MicroRNAs are stable in the circulation and may have utility as biomarkers of malignancy. We investigated whether levels of serum microRNA could discriminate women with high-grade SEOC from age matched healthy volunteers. Methods To identify microRNA of interest, microRNA expression profiling was performed on 4 SEOC cell lines and normal human ovarian surface epithelial cells. Total RNA was extracted from 500 μL aliquots of serum collected from patients with SEOC (n = 28 and age-matched healthy donors (n = 28. Serum microRNA levels were assessed by quantitative RT-PCR following preamplification. Results microRNA (miR-182, miR-200a, miR-200b and miR-200c were highly overexpressed in the SEOC cell lines relative to normal human ovarian surface epithelial cells and were assessed in RNA extracted from serum as candidate biomarkers. miR-103, miR-92a and miR -638 had relatively invariant expression across all ovarian cell lines, and with small-nucleolar C/D box 48 (RNU48 were assessed in RNA extracted from serum as candidate endogenous normalizers. No correlation between serum levels and age were observed (age range 30-79 years for any of these microRNA or RNU48. Individually, miR-200a, miR-200b and miR-200c normalized to serum volume and miR-103 were significantly higher in serum of the SEOC cohort (P  Conclusions We identified serum microRNAs able to discriminate patients with high grade SEOC from age-matched healthy controls. The addition of these microRNAs to current testing regimes may improve diagnosis for women with SEOC.

  20. Epithelial Cell Differentiation Regulated by MicroRNA-200a in Mammary Glands

    OpenAIRE

    NAGAOKA, Kentaro; Zhang, Haolin; Watanabe, Gen; Taya, Kazuyoshi

    2013-01-01

    Mammary gland epithelial cells undergo periodic cycles of proliferation, differentiation, and involution. Many studies have reported that miRNAs, which are small, non-coding RNAs, influence a variety of biological processes during posttranscriptional regulation. Here, we found that one miRNA, miR-200a, was relatively highly expressed in epithelial cell-rich organs such as mammary glands, lung, and kidney in mice. In mammary glands, miR-200a expression increased during mid-pregnancy through la...

  1. Effectiveness of the GT200 Molecular Detector: A Double-Blind Test

    CERN Document Server

    Mochán, W Luis

    2013-01-01

    The GT200 is a device that has been extensively used by the Mexican armed forces to remotely detect and identify substances such as drugs and explosives. A double blind experiment has been performed to test its effectivity. In seventeen out of twenty attempts, the GT200 failed in the hands of certified operators to find more than 1600 amphetamine pills and four bullets hidden in a randomly chosen cardboard box out of eight identical boxes distributed within a 90m$\\times$20m ballroom. This result is compatible with the 1/8 probability expected for a completely ineffectual device, and is incompatible with even a moderately effective working one.

  2. Results from Cu+Au collisions at 200 GeV in PHENIX Experiment

    International Nuclear Information System (INIS)

    Collisions of asymmetric nuclei (Cu+Au) differ essentially from the case of symmetric nuclei (Cu+Cu, Au+Au) collisions in the geometry of overlap region. This leads to a number of consequences, which provide more absolute and accurate information about fundamental properties of matter under extreme conditions. Nuclear modification factors for π-mesons in Cu+Au interactions at 200 GeV were measured in PHENIX Experiment at RHIC. New experimental data on measurement of flows of different order (v1, v2) for light hadrons in Cu+Au interactions at 200 GeV will be discussed in this paper

  3. Results from Cu+Au collisions at 200 GeV in PHENIX Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Berdnikov, Ya. A.; Kotov, D. O.; Safonov, A. S. [Federal State Autonomous Educational Institution of Higher Education “Saint-Petersburg State Polytechnical University” (Russian Federation); Ivanishchev, D. A.; Riabov, V. G.; Riabov, Yu. G.; Samsonov, V. M. [Petersburg Nuclear Physics Institute B.P. Konstantinov, National Research Centre “Kurchatov Institute” (Russian Federation)

    2016-01-22

    Collisions of asymmetric nuclei (Cu+Au) differ essentially from the case of symmetric nuclei (Cu+Cu, Au+Au) collisions in the geometry of overlap region. This leads to a number of consequences, which provide more absolute and accurate information about fundamental properties of matter under extreme conditions. Nuclear modification factors for π-mesons in Cu+Au interactions at 200 GeV were measured in PHENIX Experiment at RHIC. New experimental data on measurement of flows of different order (v{sub 1}, v{sub 2}) for light hadrons in Cu+Au interactions at 200 GeV will be discussed in this paper.

  4. Neutral water-chemical regime with hydrogen peroxide dosage at the AMB-200 unit

    International Nuclear Information System (INIS)

    Results of investigations related to estimation of erosion-corrosion process rates on feed water treatment with hydrogen peroxide at the Beloyarskaya NPP second unit are given. As follows from analysis, values of electric conductivity and iron oxide concentrations reduced two times as compared with correctionless regimes. Metal erosion rate in some feed water loop sections reduced 200-600 times. Hydrogen peroxide metering for feed water provides good condition and reliable operation of feed water loop equipment, reactor circuit and process tubes of the AMB-200 reactor unit

  5. The series of siemens SST-200 to SST-900 steam turbines in Russia

    Science.gov (United States)

    Kasilov, V. F.

    2015-04-01

    The chronology of cooperation between the transnational German concern Siemens and Russia is given. The designs of the SST-200-SST-900 series of industrial steam turbines for electrical capacities ranging from 10 to 180 MW that were installed at thermal power plants and industrial facilities of Russia in the period 2004-2014 are reviewed. The design features of the SST-600 steam turbine used as part of the PGU-200 combined-cycle plant installed at the Southwest cogeneration station are considered.

  6. Always on the starting line: ELCAT 200 - the new-generation electric vehicle

    Energy Technology Data Exchange (ETDEWEB)

    Baeckstroem, K.; Leisio, C. [ed.

    1997-11-01

    The Elcat 200 electric van can always be left charging. With most other electric van models, the situation is different. They run the risk of overcharging, which prevents continual `refuelling` of their batteries and thus considerably reduces the performance of the vehicles. The Elcat electric vehicle project has so far manufactured over 160 electric vans. Of these, the Elcat Cityvan accounts for 130, and the state-of-the-art Elcat 200 just over 30. The greatest single Elcat user is Finland Post, with 50 electric vehicles. Fifty Elcats have been sold abroad, most of them to Sweden

  7. 西门子S7 200 PLC在汽车上的应用%Applications of Siemens S7 200 PLC in Pumping Automobile

    Institute of Scientific and Technical Information of China (English)

    钱伟中

    2013-01-01

    主要介绍泵遥汽车液压系统中电器控制部分存在的一些问题,通过用TP178 Micro触摸屏和S7 200 PLC进行改造,使系统性能得到很大提高,尤其在泵送排量方面的控制性能更佳,为以后在这方面的开发提供参考和借鉴.

  8. Inhibition of miR-200c Restores Endothelial Function in Diabetic Mice Through Suppression of COX-2.

    Science.gov (United States)

    Zhang, Huina; Liu, Jian; Qu, Dan; Wang, Li; Luo, Jiang-Yun; Lau, Chi Wai; Liu, Pingsheng; Gao, Zhen; Tipoe, George L; Lee, Hung Kay; Ng, Chi Fai; Ma, Ronald Ching Wan; Yao, Xiaoqiang; Huang, Yu

    2016-05-01

    Endothelial dysfunction plays a crucial role in the development of diabetic vasculopathy. Our initial quantitative PCR results showed an increased miR-200c expression in arteries from diabetic mice and patients with diabetes. However, whether miR-200c is involved in diabetic endothelial dysfunction is unknown. Overexpression of miR-200c impaired endothelium-dependent relaxations (EDRs) in nondiabetic mouse aortas, whereas suppression of miR-200c by anti-miR-200c enhanced EDRs in diabetic db/db mice. miR-200c suppressed ZEB1 expression, and ZEB1 overexpression ameliorated endothelial dysfunction induced by miR-200c or associated with diabetes. More importantly, overexpression of anti-miR-200c or ZEB1 in vivo attenuated miR-200c expression and improved EDRs in db/db mice. Mechanistic study with the use of COX-2(-/-) mice revealed that COX-2 mediated miR-200c-induced endothelial dysfunction and that miR-200c upregulated COX-2 expression in endothelial cells through suppression of ZEB1 and increased production of prostaglandin E2, which also reduced EDR. This study demonstrates for the first time to our knowledge that miR-200c is a new mediator of diabetic endothelial dysfunction and inhibition of miR-200c rescues EDRs in diabetic mice. These new findings suggest the potential usefulness of miR-200c as the target for drug intervention against diabetic vascular complications. PMID:26822089

  9. NAL200 Series Level Compensator′s Adjustment Method%NAL200系列水准仪补偿器的调校方法

    Institute of Scientific and Technical Information of China (English)

    曹慧楠; 王健; 张太平

    2014-01-01

    This article introduced the NAL200 series level compensator the characteristics and working principle of the level and the compensator inspection and correction method, and gives the detail level, correction methods for basic indexes such as the adjustment of round bubble, I Angle error correction, the compensation accuracy of correction, compensator cross error correction and so on, in the process of measurement for the user to ensure the precision of the instrument to provide the reference.%介绍了NAL200系列水准仪的特点、水准仪工作原理以及补偿器检验和校正的方法,并详细给出了水准仪基本指标的校正方法,如圆水泡的调整、i角误差的校正、补偿精度的校正、补偿器交叉误差的校正等,为用户在进行测量过程中保证仪器的精度提供参考。

  10. 24 CFR 598.200 - Who nominates an area for designation?

    Science.gov (United States)

    2010-04-01

    ... DESIGNATIONS Nomination Procedure § 598.200 Who nominates an area for designation? Applicants for empowerment... the area is located, except as provided in §§ 598.500, 598.510, and 598.515. The nomination must be... of the designation process, and must contain complete and accurate information. (Approved by...

  11. Merelaevanduse erastamisega sai riik 200 miljoniga vastu pükse / Martin Hanson

    Index Scriptorium Estoniae

    Hanson, Martin, 1984-

    2006-01-01

    Ilmunud ka: Delovõje Vedomosti 28. juuni lk. 4-5. Eesti Merelaevanduse pankroti tõttu jääb Eesti riik ilma 200 miljonist kroonist. Vt. samas: Merelaevanduse kurbmäng; Sarnet: raha tulnuks kohe kätte nõuda; ESCO Shipping töötab edasi

  12. 20 CFR 200.9 - Selection of members of Actuarial Advisory Committee.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Selection of members of Actuarial Advisory... ADMINISTRATION § 200.9 Selection of members of Actuarial Advisory Committee. (a) Introduction. Under section 15(f... actuaries to serve on an Actuarial Advisory Committee. This section describes how the two actuaries...

  13. 7 CFR 330.200 - Movement of plant pests regulated; permits required.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Movement of plant pests regulated; permits required... AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FEDERAL PLANT PEST REGULATIONS; GENERAL; PLANT PESTS; SOIL, STONE, AND QUARRY PRODUCTS; GARBAGE Movement of Plant Pests § 330.200 Movement...

  14. Analysis of the NHR-200 nuclear sea water desalination plant and its interface design

    International Nuclear Information System (INIS)

    Safety is important to nuclear sea water desalination, and concerns the safety of the reactor itself and the prevention of potable water contamination. The NHR-200 has an integrated arrangement with natural circulation. It is an LWR of the vessel VAX with self-pressurized performance. Safety is achieved by its inherent and passive safety features, including a reactor core that is always covered by coolant under any LOCA conditions, a large negative reactivity feedback, a fairly large departure from nucleate boiling ratio, perfect containment systems, etc. For these reasons, the site of the NHR-200 can be located near to a populated arm The NHR-200 nuclear desalination plant is an integrated plant. Coupling between the NHR-200 and the multi-effect distillation plant is designed to prevent potable water from being contaminated through multi-isolation barriers. The composition of the water production costs and the results of sensitivity analysis show that if the water production costs are to be reduced greatly, investment in the water plant will have to be lower. A high load factor is also an important factor if these costs are to be reduced. (author)

  15. 46 CFR 174.200 - Damaged stability in machinery spaces for all OSVs.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Damaged stability in machinery spaces for all OSVs. 174... Vessels § 174.200 Damaged stability in machinery spaces for all OSVs. Each OSV must be shown by design... case of damage between any two watertight bulkheads in each machinery space....

  16. Aulice to Build 1,200,000 Units/Y All- steel Tires Project

    Institute of Scientific and Technical Information of China (English)

    Li Zao

    2012-01-01

    To adapt to the rapid development of automobile industry and to meet the market demand on high- performance tires, upon investigation, Hubei Aulice Tire Co., Ltd. intends to build all-steel radial tire production project with the output of 1,200,000 units per year.

  17. Waste segregation analysis for salt well pumping in the 200 W Area -- Task 3.4

    International Nuclear Information System (INIS)

    There is an estimated 7 million liters (1.9 million gallons) of potentially complexed waste that need to be pumped from single-shell tanks (SST) in the 200 West Area. This represents up to 40% of the salt well liquor that needs to be pumped in the 200 West Area. There are three double-shell (DST) tanks in the 241-SY tank farm in the 200 West Area. Tank 241-SY-101 is full and not usable. Tank 241-SY-102 has a transuranic (TRU) sludge in the bottom. Current rules prohibit mixing complexed waste with TRU waste. Tank 241-SY-103 has three major problems. First, 241-SY-103 is on the Flammable Watch list. Second, adding waste to tank 241-SY-103 has the potential for an episodic release of hydrogen gas. Third, 241-SY-103 will not hold all of the potentially complexed waste from the SSTs. This document looks at more details regarding the salt well pumping of the 200 West Area tank farm. Some options are considered but it is beyond the scope of this document to provide an in-depth study necessary to provide a defensible solution to the complexed waste problem

  18. 17 CFR 200.24a - Director of the Office of Consumer Affairs.

    Science.gov (United States)

    2010-04-01

    ... COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General Organization § 200.24a Director of the Office of Consumer Affairs. The Director of the Office of... the Commission; and increasing public knowledge of the functions of the Commission. (b)...

  19. Sensitivity of the Baikal neutrino telescope NT-200 to point sources of very high energy neutrinos

    International Nuclear Information System (INIS)

    The sensitivity of the deep underwater muon and neutrino detector 'NT-200' in lake Baikal to point sources of extraterrestrial neutrinos is calculated. Results are given for different assumptions on the neutrino source spectrum and the reconstruction capabilities of the detector. (orig.)

  20. 7 CFR 1755.200 - RUS standard for splicing copper and fiber optic cables.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false RUS standard for splicing copper and fiber optic..., ACCEPTABLE MATERIALS, AND STANDARD CONTRACT FORMS § 1755.200 RUS standard for splicing copper and fiber optic... fiber optic cables. Typical applications of these methods include aerial, buried, and...

  1. Development program for a 200 kW, cw gyrotron. Final report

    International Nuclear Information System (INIS)

    Development of a millimeter-wave device to produce 200 kW of continuous wave power at 60 GHz is described. The device, a gyrotron oscillator, is intended for electron-cyclotron heating of fusion plasmas. The design philosophy is herein discussed and experimental results, both diagnostic and long pulse, are given

  2. 50 CFR 216.200 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... of Offshore Oil and Gas Facilities in the U.S. Beaufort Sea § 216.200 Specified activity and... and pipeline construction, vessel and helicopter activity; and oil production activities, including ice road construction, and vessel and helicopter activity, but excluding seismic operations....

  3. 37 CFR 2.200 - Assignment records open to public inspection.

    Science.gov (United States)

    2010-07-01

    ... the Patent and Trademark Office § 2.200 Assignment records open to public inspection. (a)(1) Separate...) are open to public inspection at the Office, and copies of those assignment records may be obtained... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Assignment records open...

  4. 21 CFR 200.15 - Definition of term “insulin.”

    Science.gov (United States)

    2010-04-01

    ....15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL GENERAL General Provisions § 200.15 Definition of term “insulin.” For purposes of sections 801 and 802 of the act and this title, the term insulin means the active principle of the...

  5. Climate Prediction Center (CPC) Area-average 200-hPa Zonal Wind Anomalies

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This is one of the CPC?s Monthly Atmospheric and SST Indices. It is the 200-hPa zonal wind anomalies averaged over the area 5oN ? 5oS, 165oW-110oW. The anomalies...

  6. Measurements on the SPS 200 MHz Travelling Wave Cavity towards an Impedance Model

    CERN Document Server

    Roggen, Toon; Caspers, Fritz; Vollinger, Christine; CERN. Geneva. ATS Department

    2016-01-01

    This note discusses the contribution of the SPS 200 MHz TWC (Travelling Wave Cavity) to the SPS longitudinal impedance model. The measurement method and setup is briefly explained and a comparison with simulations is discussed for both the fundamental pass band (FPB) as well as the Higher Order Modes (HOMs). In addition a number of improvements to the measurement setup are discussed.

  7. Emulsion stars of 200, 300 and 400 GeV protons

    International Nuclear Information System (INIS)

    Shower particle multiplicities of proton stars increase from 13.2+-0.2 at 200 to 16.8+-0.4 at 400 GeV, despite the constancy of heavy prongs. Angular distributions and energy spectrum of heavy prongs are given. There is a steady evolution of characteristics of stars with primary energy attributable to cluster emission. (author)

  8. Preparation and Dynamic Tensile Behavior of C200 Green Reactive Powder Concrete

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yunsheng; SUN Wei; LIU Sifeng; JIAO Chujie; LAI Jianzhong

    2006-01-01

    A new type of green reactive powder concrete (GRPC) with compressive strength of 200 MPa is prepared by utilizing composite mineral admixtures,natural fine aggregates,and short and fine steel fibers.The quasi-static mechanical properties (mechanical strength,toughness,fracture energy and interracial bonding strength) of GRPC specimens,cured in three different types of regimes,are investigated.The experimental results show that the mechanical properties of the C200 GRPC made with the powder binders that is composed of 40% of Portland cement,25% of ultra fine slag,25% of ultra fine fly ash and 10% of silica fume are better than the others'.The corresponding compressive strength,flexural strength and fracture energy are more than 200 MPa,and 30 000 J/m2 respectively.The dynamic tensile behavior of the C200 GRPC is also investigated through the split Hopkinson pressure bar (SHPB) according to the spalling phenomenon.The dynamic testing results demonstrate that strain rate has an important effect on the dynamic tensile behavior of GRPC.With the increase of strain rate,its peak stress and relevant strain increase.The GRPC exhibits an excellent strain ratio stiffening effect under the dynamic tensile Ioad with high strain ratio,resulting in a significant change of the fracture pattern.

  9. Radioactive liquid wastes discharged to ground in the 200 Areas during 1978

    International Nuclear Information System (INIS)

    This document is issued quarterly for the purpose of summarizing the radioactive liquid wastes that have been discharged to the ground in the 200 Areas. In addition to data for 1978, cumulative data since plant startup are presented. Also, in this document is a listing of decayed activity to the various plant sites

  10. 46 CFR 170.200 - Estimated lightweight vertical center of gravity.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Estimated lightweight vertical center of gravity. 170... Centers of Gravity § 170.200 Estimated lightweight vertical center of gravity. (a) Each tank vessel that... calculations required by §§ 170.170 and 172.065, the vertical center of gravity of a tank vessel in...

  11. Increasing N200 Potentials Via Visual Stimulus Depicting Humanoid Robot Behavior.

    Science.gov (United States)

    Li, Mengfan; Li, Wei; Zhou, Huihui

    2016-02-01

    Achieving recognizable visual event-related potentials plays an important role in improving the success rate in telepresence control of a humanoid robot via N200 or P300 potentials. The aim of this research is to intensively investigate ways to induce N200 potentials with obvious features by flashing robot images (images with meaningful information) and by flashing pictures containing only solid color squares (pictures with incomprehensible information). Comparative studies have shown that robot images evoke N200 potentials with recognizable negative peaks at approximately 260 ms in the frontal and central areas. The negative peak amplitudes increase, on average, from 1.2 μV, induced by flashing the squares, to 6.7 μV, induced by flashing the robot images. The data analyses support that the N200 potentials induced by the robot image stimuli exhibit recognizable features. Compared with the square stimuli, the robot image stimuli increase the average accuracy rate by 9.92%, from 83.33% to 93.25%, and the average information transfer rate by 24.56 bits/min, from 72.18 bits/min to 96.74 bits/min, in a single repetition. This finding implies that the robot images might provide the subjects with more information to understand the visual stimuli meanings and help them more effectively concentrate on their mental activities. PMID:26621216

  12. A Dictionary of Russian Idioms and Colloquialisms; 2,200 Expressions with Examples.

    Science.gov (United States)

    Jaszczun, Wasyl; Krynski, Szymon

    Some 2,200 expressions with illustrative sentences in Russian are contained in this dictionary intended for use as a reference work by students in intermediate and advanced Russian studies. The idioms or colloquialisms are rendered into English and are derived primarily from the classics of Russian literature. The dictionary covers phraseological…

  13. The PS 200 catching trap: A new tool for ultra-low energy antiproton physics

    International Nuclear Information System (INIS)

    Approximately one million antiprotons have been trapped and electron cooled in the PS200 catching trap from a single fast extracted pulse from LEAR. The system is described in detail, different extraction schemes are discussed, and possible applications of this instrument to ultra-low energy atomic and nuclear physics with antiprotons are mentioned

  14. Revised Hydrogeology for the Suprabasalt Aquifer System, 200-East Area and Vicinity, Hanford Site, Washington

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Bruce A.; Bjornstad, Bruce N.; Schalla, Ronald; Webber, William D.

    2000-04-20

    This study supports the Hanford Groundwater/Vadose integration project objectives to better understand the risk of groundwater contamination and potential risk to the public via groundwater flow paths. The primary objective of this study was to refine the conceptual groundwater flow model for the 200-East Area and vicinity.

  15. 15 CFR 200.109 - Shipping, insurance, and risk of loss.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Shipping, insurance, and risk of loss..., SERVICES, PROCEDURES, AND FEES § 200.109 Shipping, insurance, and risk of loss. (a) Shipment of apparatus... as to minimize the likelihood of damage in shipment and handling. Suggestions on packing and...

  16. 33 CFR 166.200 - Shipping safety fairways and anchorage areas, Gulf of Mexico.

    Science.gov (United States)

    2010-07-01

    ... Navigation or danger markings must be installed as required by 33 CFR Subchapter C. (c) Special Conditions...: For Federal Register citations affecting § 166.200, see the List of CFR Sections Affected, which... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Shipping safety fairways...

  17. 17 CFR 200.83 - Confidential treatment procedures under the Freedom of Information Act.

    Science.gov (United States)

    2010-04-01

    ... categories of information (see, e.g., 17 CFR 240.24b-2) or where the Commission has not specified that an... provisions of the Freedom of Information Act and Commission rules thereunder. See 17 CFR 200.80(d)(6)....

  18. 20 CFR 200.5 - Protection of privacy of records maintained on individuals.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Protection of privacy of records maintained... ADMINISTRATION GENERAL ADMINISTRATION § 200.5 Protection of privacy of records maintained on individuals. (a... as his full name, date of birth, and social security number. The system manager shall respond to...

  19. 40 CFR 80.200 - What gasoline is subject to the sulfur standards and requirements?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What gasoline is subject to the sulfur... (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Sulfur Gasoline Sulfur Standards § 80.200 What gasoline is subject to the sulfur standards and requirements? For the purpose...

  20. CO tolerance by the PEMFC operational at temperatures up to 200°C

    DEFF Research Database (Denmark)

    Li, Qingfeng; He, Ronghuan; Gao, Ji-An; Jensen, Jens Oluf; Bjerrum, Niels

    The CO poisoning effect on carbon-supported platinum catalysts in polymer electrolyte membrane fuel cells has been investigated in a temperature range from 125 to 200°C with the phosphoric acid-doped polybenzimidazole membranes as electrolyte. The effect is very temperature-dependent and can be...