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Sample records for astatine 200

  1. Radiochemistry of astatine

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, T J; Dombsky, M; D' Auria, J M; Ward, T E

    1988-01-01

    This monograph is a review of the literature through 1987 and covers the methods of producing the radioisotopes of astatine and the inorganic, nuclear, and organic chemistry of astatine. The discussion is limited to chemical and physical chemical properties of astatine. The monograph, after the introduction, is divided into chapters titled: production methods, nuclear spectroscopy, chemistry of astatine, separation and isolation (dry and wet), and selected procedures. 209 refs., 15 figs., 7 tabs. (DLC)

  2. Discovery of the astatine, radon, francium, and radium isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Fry, C.; Thoennessen, M., E-mail: thoennessen@nscl.msu.edu

    2013-09-15

    Thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is described. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  3. Discovery of the astatine, radon, francium, and radium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  4. Discovery of the astatine, radon, francium, and radium isotopes

    Science.gov (United States)

    Fry, C.; Thoennessen, M.

    2013-09-01

    Thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is described. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  5. Delayed and In-beam Spectroscopy on Francium and Astatine Nuclei at the Proton Drip Line

    Energy Technology Data Exchange (ETDEWEB)

    Uusitalo, J.; Jakobsson, U. [Department of Physics, University of Jyvaeskylae (Finland); Collaboration: RITU-Gamma Gollaboration

    2011-11-30

    Delayed and in-beam spectroscopy on francium and astatine nuclei at and beyond the proton drip line has been performed. In neutron deficient astatine nuclei a shift to deformed shapes as a function of decreasing neutron has been obtained. In neutron deficient francium isotope the same shift is evident.

  6. Delayed and In-beam Spectroscopy on Francium and Astatine Nuclei at the Proton Drip Line

    Science.gov (United States)

    Uusitalo, J.; Jakobsson, U.

    2011-11-01

    Delayed and in-beam spectroscopy on francium and astatine nuclei at and beyond the proton drip line has been performed. In neutron deficient astatine nuclei a shift to deformed shapes as a function of decreasing neutron has been obtained. In neutron deficient francium isotope the same shift is evident.

  7. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  8. Measurement of the first ionization potential of astatine by laser ionization spectroscopy.

    Science.gov (United States)

    Rothe, S; Andreyev, A N; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yuri; Köster, U; Lane, J F W; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt, K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.31751(8) eV. New ab initio calculations are performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of superheavy element 117, the heaviest homologue of astatine.

  9. Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Jakobsson, U., E-mail: ulrjak@kth.se; Cederwall, B. [KTH, The Division of Nuclear Physics, AlbaNova University Center, SE-10691 Stockholm (Sweden); Uusitalo, J.; Auranen, K.; Badran, H.; Cox, D. M.; Grahn, T.; Greenlees, P. T.; Julin, R.; Juutinen, S.; Herzáň, A.; Konki, J.; Leino, M.; Mallaburn, M.; Pakarinen, J.; Papadakis, P.; Partanen, J.; Rahkila, P.; Sandzelius, M.; Sarén, J. [University of Jyvaskyla, Department of Physics, P.O. Box 35, FI-40014 University of Jyvaskyla (Finland); and others

    2015-10-15

    Low-lying states in neutron-deficient astatine and francium nuclei have been studied by means of in-beam and delayed spectroscopy. The 13/2{sup +} state has been observed in francium nuclei with a similar down-sloping trend as in neighbouring astatine and bismuth isotopes, as a function of decreasing neutron number. A systematic trend can also now be seen for the 1/2{sup +} state both in astatine and francium nuclei, where the level energy decreases steeply as a function of neutron number when moving further away from the neutron shell closure. This trend is very similar between astatine nuclei and their francium isotones. Moreover, shape coexistence has been observed between the 13/2{sup +} state and the spherical 9/2{sup −} ground state in {sup 203}Fr and {sup 205}Fr.

  10. Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei

    Science.gov (United States)

    Jakobsson, U.; Uusitalo, J.; Auranen, K.; Badran, H.; Cederwall, B.; Cox, D. M.; Grahn, T.; Greenlees, P. T.; Julin, R.; Juutinen, S.; HerzáÅ, A.; Konki, J.; Leino, M.; Mallaburn, M.; Pakarinen, J.; Papadakis, P.; Partanen, J.; Rahkila, P.; Sandzelius, M.; Sarén, J.; Scholey, C.; Sorri, J.; Stolze, S.

    2015-10-01

    Low-lying states in neutron-deficient astatine and francium nuclei have been studied by means of in-beam and delayed spectroscopy. The 13/2+ state has been observed in francium nuclei with a similar down-sloping trend as in neighbouring astatine and bismuth isotopes, as a function of decreasing neutron number. A systematic trend can also now be seen for the 1/2+ state both in astatine and francium nuclei, where the level energy decreases steeply as a function of neutron number when moving further away from the neutron shell closure. This trend is very similar between astatine nuclei and their francium isotones. Moreover, shape coexistence has been observed between the 13/2+ state and the spherical 9/2- ground state in 203Fr and 205Fr.

  11. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom

    2015-01-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...

  12. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    NARCIS (Netherlands)

    Rothe, S.; Andreyev, A. N.; Antalic, S.; Borschevsky, A.; Capponi, L.; Cocolios, T. E.; De Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.; Kaldor, U.; Kudryavtsev, Yuri; Koester, U.; Lane, J. F. W.; Lassen, J.; Liberati, V.; Lynch, K. M.; Marsh, B. A.; Nishio, K.; Pauwels, D.; Pershina, V.; Popescu, L.; Procter, T. J.; Radulov, D.; Raeder, S.; Rajabali, M. M.; Rapisarda, E.; Rossel, R. E.; Sandhu, K.; Seliverstov, M. D.; Sjoedin, A. M.; Van den Bergh, P.; Van Duppen, P.; Venhart, M.; Wakabayashi, Y.; Wendt, K. D. A.

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical

  13. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  14. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates

    DEFF Research Database (Denmark)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per

    2016-01-01

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even sing...... of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies....

  15. Laser photodetachment of radioactive ions: towards the determination of the electronegativity of astatine

    CERN Multimedia

    Rothe, Sebastian; Welander, Jakob Emanuel; Chrysalidis, Katerina; Day Goodacre, Thomas; Fedosseev, Valentine; Fiotakis, Spyridon; Forstner, Oliver; Heinke, Reinhard Matthias; Johnston, Karl; Kron, Tobias; Koester, Ulli; Liu, Yuan; Marsh, Bruce; Ringvall Moberg, Annie; Rossel, Ralf Erik; Seiffert, Christoph; Studer, Dominik; Wendt, Klaus; Hanstorp, Dag

    2017-01-01

    Negatively charged ions are mainly stabilized through the electron correlation effect. A measure of the stability of a negative ion is the electron affinity, which the energy gain by attaching an electron to a neutral atom. This fundamental quantity is, due to the almost general lack of bound excited states, the only atomic property that can be determined with high accuracy for negative ions. We will present the results of the first laser photodetachment studies of radioactive negative ions at CERN-ISOLDE. The photodetachment threshold for the radiogenic iodine isotope 128I was measured successfully, demonstrating the performance of the upgraded GANDALPH experimental beam line. The first detection of photo-detached astatine atoms marks a milestone towards the determination of the EA of this radioactive element.

  16. Complexation study on no-carrier-added astatine with insulin: A candidate radiopharmaceutical

    Energy Technology Data Exchange (ETDEWEB)

    Lahiri, Susanta [Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064 (India)], E-mail: susanta.lahiri@saha.ac.in; Roy, Kamalika [Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064 (India); Sen, Souvik [Berhampur Sadar Hospital, Berhampur, Murshidabad 742 101 (India)

    2008-12-15

    No-carrier-added astatine radionuclides produced in the {sup 7}Li-irradiated lead matrix were separated from bulk lead nitrate target by complexing At with insulin, followed by dialysis. The method offers simultaneous separation of At from lead as well as its complexation with insulin. The At-insulin complex might be a potential radiopharmaceutical in the treatment of hepatocellular carcinoma. The stability of At-insulin complex was checked by dialysis against deionized water and Ringer lactate (RL) solution. It has been found that the half-life of At-insulin complex is about {approx}12 h, when dialyzed against deionized water and is only 6 h, when dialyzed against RL solution having the same composition as blood serum. The 6 h half-life of this Insulin-At complex is perfect for killing cancer cells from external cell surfaces as the half-life of internalization of insulin molecule inside the cell is 7-12 h.

  17. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron affinity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photo-detachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral line width of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in off-line tests by the clear observation of the photo-detachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148.

  18. Adsorption of the astatine species on a gold surface: A relativistic density functional theory study

    Science.gov (United States)

    Demidov, Yuriy; Zaitsevskii, Andréi

    2018-01-01

    We report first-principle based studies of the adsorption interaction of astatine species on a gold surface. These studies are aimed primarily at the support and interpretation of gas chromatographic experiments with superheavy elements, tennessine (Ts, Z = 117), a heavier homologue of At, and possibly its pseudo-homologue nihonium (Nh, Z = 113). We use gold clusters with up to 69 atoms to simulate the adsorption sites and estimate the desorption energies of At & AtOH from a stable gold (1 1 1) surface. To describe the electronic structure of At -Aun and AtOH -Aun complexes, we combine accurate shape-consistent relativistic pseudopotentials and non-collinear two-component relativistic density functional theory. The predicted desorption energies of At and AtOH on gold are 130 ± 10 kJ/mol and 90 ± 10 kJ/mol, respectively. These results confirm the validity of the estimates derived from chromatographic data (147 ± 15 kJ/mol for At, and 100-10+20 kJ/mol for AtOH).

  19. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  20. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  1. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  2. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott [Univ. of Washington, Seattle, WA (United States)

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  3. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  4. An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211

    Energy Technology Data Exchange (ETDEWEB)

    O’Hara, Matthew J.; Krzysko, Anthony J.; Niver, Cynthia M.; Morrison, Samuel S.; Owsley, Stanley L.; Hamlin, Donald K.; Dorman, Eric F.; Scott Wilbur, D.

    2017-04-01

    Astatine-211 (211At) is a promising cyclotron-produced radionuclide being investigated for use in targeted alpha therapy of blood borne and metastatic cancers, as well as treatment of tumor remnants after surgical resections. The isolation of trace quantities of 211At, produced within several grams of a Bi metal cyclotron target, involves a complex, multi-step procedure: (1) Bi metal dissolution in strong HNO3, (2) distillation of the HNO3 to yield Bi salts containing 211At, (3) dissolution of the salts in strong HCl, (4) solvent extraction of 211At from bismuth salts with diisopropyl ether (DIPE), and (5) back-extraction of 211At from DIPE into NaOH, leading to a purified 211At product. Step (1) has been addressed first to begin the process of automating the onerous 211At isolation process. A computer-controlled Bi target dissolution system has been designed. The system performs in-line dissolution of Bi metal from the target assembly using an enclosed target dissolution block, routing the resulting solubilized 211At/Bi mixture to the subsequent process step. The primary parameters involved in Bi metal solubilization (HNO3 concentration and influent flow rate) were optimized prior to evaluation of the system performance on replicate cyclotron irradiated targets. The results indicate that the system performs reproducibly, having nearly quantitative release of 211At from irradiated targets, with cumulative 211At recoveries that follow a sigmoidal function. The predictable nature of the 211At release profile allows the user to tune the system to meet target processing requirements.

  5. Reagents for astatination of biomolecules. 2. Conjugation of anionic boron cage pendant groups to a protein provides a method for direct labeling that is stable to in vivo deastatination.

    Science.gov (United States)

    Wilbur, D Scott; Chyan, Ming-Kuan; Hamlin, Donald K; Vessella, Robert L; Wedge, Timothy J; Hawthorne, M Frederick

    2007-01-01

    Cancer-targeting biomolecules labeled with 211At must be stable to in vivo deastatination, as control of the 211At distribution is critical due to the highly toxic nature of alpha-particle emission. Unfortunately, no astatinated aryl conjugates have shown in vivo stability toward deastatination when (relatively) rapidly metabolized proteins, such as monoclonal antibody Fab' fragments, are labeled. As a means of increasing the in vivo stability of 211At-labeled proteins, we have been investigating antibody conjugates of boron cage moieties. In this investigation, protein-reactive derivatives containing a nido-carborane (2), a bis-nido-carborane derivative (Venus Flytrap Complex, 3), and four 2-nonahydro-closo-decaborate(2-) derivatives (4-7) were prepared and conjugated with an antibody Fab' fragment such that subsequent astatination and in vivo tissue distributions could be obtained. To aid in determination of stability toward in vivo deastatination, the Fab'-borane conjugates were also labeled with 125I, and that material was coinjected with the 211At-labeled Fab'. For comparison, direct labeling of the Fab' with 125I and 211At was conducted. Direct labeling with Na[125I]I and Chloramine-T gave an 89% radiochemical yield. However, direct labeling of the Fab' with Na[211At]At and Chloramine-T resulted in a yield of Studies to optimize the closo-decaborate(2-) conjugates for protein labeling are underway.

  6. Deutsch 100, 200, 300.

    Science.gov (United States)

    Manitoba Dept. of Education, Winnipeg.

    Manitoba's curriculum guide for German 100, 200, and 300 is designed to (1) make teachers of these courses aware of the official policy concerning the nature, goals, and objectives of the courses and approved teaching materials, and (2) provide instructional guidelines. The guide provides information about three sets of teaching materials from…

  7. Hans Christian Andersen 200

    Index Scriptorium Estoniae

    2005-01-01

    Hollandi lasteraamatute autorist ja illustraatorist Max Velthuijs'ist (1923-2005). H.C. Anderseni 200. sünniaastapäevale pühendatud lasteraamatunäitusest Rahvusraamatukogus. Eksponeeritakse ka Tiina Reinsalu akvarelle raamatule "Ööbik"

  8. Comment: 200 [Taxonomy Icon

    Lifescience Database Archive (English)

    Full Text Available Japanese tree frog Hyla japonica Hyla_japonica_L.png 200.png Takeru Nakazato (Database Center for Life...合データベースセンター) Photo: Takeru Nakazato (Database Center for Life Science) nakazato 2009/11/04 17:26:47 2010/01/14 20:11:35 ...

  9. Hanford 200 Areas Development Plan

    Energy Technology Data Exchange (ETDEWEB)

    Rinne, C.A.; Daly, K.S.

    1993-08-01

    The purpose of the Hanford 200 Areas Development Plan (Development Plan) is to guide the physical development of the 200 Areas (which refers to the 200 East Area, 200 West Area, and 200 Area Corridor, located between the 200 East and 200 West Areas) in accordance with US Department of Energy (DOE) Order 4320.lB (DOE 1991a) by performing the following: Establishing a land-use plan and setting land-use categories that meet the needs of existing and proposed activities. Coordinating existing, 5-year, and long-range development plans and guiding growth in accordance with those plans. Establishing development guidelines to encourage cost-effective development and minimize conflicts between adjacent activities. Identifying site development issues that need further analysis. Integrating program plans with development plans to ensure a logical progression of development. Coordinate DOE plans with other agencies [(i.e., Washington State Department of Ecology (Ecology) and US Environmental Protection Agency (EPA)]. Being a support document to the Hanford Site Development Plan (DOE-RL 1990a) (parent document) and providing technical site information relative to the 200 Areas.

  10. 49 CFR 179.200-10 - Welding.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Welding. 179.200-10 Section 179.200-10... Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-10 Welding. (a) All joints... W (IBR, see § 171.7 of this subchapter). Welding procedures, welders and fabricators shall be...

  11. 29 CFR 99.200 - Audit requirements.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Audit requirements. 99.200 Section 99.200 Labor Office of the Secretary of Labor AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Audits § 99.200 Audit requirements. (a) Audit required. Non-Federal entities that expend $300,000 or more in a...

  12. 24 CFR 100.200 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... CONDUCT UNDER THE FAIR HOUSING ACT Prohibition Against Discrimination Because of Handicap § 100.200... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Purpose. 100.200 Section 100.200 Housing and Urban Development Regulations Relating to Housing and Urban Development OFFICE OF ASSISTANT...

  13. 24 CFR 200.80 - Mortgage form.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgage form. 200.80 Section 200... Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Mortgage Provisions § 200.80 Mortgage form. The mortgage shall...

  14. 27 CFR 200.55 - Content.

    Science.gov (United States)

    1999-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 1999-04-01 1999-04-01 false Content. 200.55 Section 200.55 ALCOHOL, TOBACCO AND OTHER EXCISE TAXES-Continued RULES OF PRACTICE IN PERMIT PROCEEDINGS Hearing Procedure Citations § 200.55 Content. (a) Citation for the suspension, revocation or annulment of...

  15. 34 CFR 200.40 - Technical assistance.

    Science.gov (United States)

    2010-07-01

    ... Programs Operated by Local Educational Agencies Lea and School Improvement § 200.40 Technical assistance. (a) An LEA that identifies a school for improvement under § 200.32 must ensure that the school receives technical assistance as the school develops and implements its improvement plan under § 200.41 and...

  16. 17 CFR 200.552 - NEPA planning.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false NEPA planning. 200.552 Section 200.552 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT... § 200.552 NEPA planning. Where it is reasonably foreseeable by the Commission that it may be required to...

  17. 10 CFR 1021.200 - DOE planning.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false DOE planning. 1021.200 Section 1021.200 Energy DEPARTMENT... Decisionmaking § 1021.200 DOE planning. (a) DOE shall provide for adequate and timely NEPA review of DOE... accordance with 40 CFR 1501.2 and this section. In its planning for each proposal, DOE shall include adequate...

  18. 20 CFR 200.6 - Open meetings.

    Science.gov (United States)

    2010-04-01

    ... security intelligence investigation, confidential information furnished only by the confidential source, (E... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Open meetings. 200.6 Section 200.6 Employees' Benefits RAILROAD RETIREMENT BOARD GENERAL ADMINISTRATION GENERAL ADMINISTRATION § 200.6 Open meetings. (a...

  19. 24 CFR 200.61 - Title.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Title. 200.61 Section 200.61... Requirements for Existing Projects General Requirements § 200.61 Title. (a) Marketable title to the project must be vested in the mortgagor as of the date the mortgage is filed for record. (b) Title evidence for...

  20. 28 CFR 5.200 - Registration.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Registration. 5.200 Section 5.200 Judicial Administration DEPARTMENT OF JUSTICE ADMINISTRATION AND ENFORCEMENT OF FOREIGN AGENTS REGISTRATION ACT OF 1938, AS AMENDED § 5.200 Registration. (a) Registration under the Act is accomplished by the...

  1. 23 CFR 200.5 - Definitions.

    Science.gov (United States)

    2010-04-01

    ...”, “American Indian or Alaskan Native.” Additional subcategories based on national origin or primary language... 23 Highways 1 2010-04-01 2010-04-01 false Definitions. 200.5 Section 200.5 Highways FEDERAL...-IMPLEMENTATION AND REVIEW PROCEDURES § 200.5 Definitions. The following definitions shall apply for the purpose...

  2. 24 CFR 200.635 - Compliance.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Compliance. 200.635 Section 200.635... GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.635 Compliance... Department will enforce compliance through the procedures outlined in 24 CFR part 108. ...

  3. 46 CFR 184.200 - General.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false General. 184.200 Section 184.200 Shipping COAST GUARD... MISCELLANEOUS SYSTEMS AND EQUIPMENT Cooking and Heating § 184.200 General. Cooking and heating equipment must be... restricted by § 184.202 of this part. ...

  4. 36 CFR 200.2 - Field organization.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Field organization. 200.2 Section 200.2 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE ORGANIZATION, FUNCTIONS, AND PROCEDURES Organization § 200.2 Field organization. The field organization of the Forest...

  5. 38 CFR 200.1 - Purpose.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Purpose. 200.1 Section 200.1 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT § 200.1 Purpose. These regulations set out AFRH environmental policy and...

  6. 21 CFR 1271.200 - Equipment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Equipment. 1271.200 Section 1271.200 Food and... CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.200 Equipment. (a) General. To prevent the introduction, transmission, or spread of communicable diseases, equipment used in the...

  7. 24 CFR 200.83 - Interest rate.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Interest rate. 200.83 Section 200... Eligibility Requirements for Existing Projects Mortgage Provisions § 200.83 Interest rate. (a) The mortgage shall bear interest at the rate agreed upon by the mortgagee and the mortgagor. (b) Interest shall be...

  8. 17 CFR 200.10 - The Commission.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false The Commission. 200.10 Section 200.10 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General Organization § 200.10 The Commission. The Commission is composed...

  9. 24 CFR 200.76 - Smoke detectors.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Smoke detectors. 200.76 Section 200... Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Property Requirements § 200.76 Smoke detectors. Smoke detectors...

  10. 17 CFR 200.506 - Derivative classification.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Derivative classification. 200.506 Section 200.506 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION... Information and Material § 200.506 Derivative classification. Any document that includes paraphrases...

  11. 29 CFR 548.200 - Requirements.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Requirements. 548.200 Section 548.200 Labor Regulations... ESTABLISHED BASIC RATES FOR COMPUTING OVERTIME PAY Interpretations Requirements for A Basic Rate § 548.200 Requirements. The following conditions must be satisfied if a “basic” rate is to be considered proper under...

  12. CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and Function

    Directory of Open Access Journals (Sweden)

    Drahomíra Holmannová

    2012-01-01

    Full Text Available CD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to the Ig superfamily containing a two immunoglobulin‑like domain (V, C. CD200 is broadly distributed in a variety of cell types, whereas CD200R is primarily expressed in myeloid and lymphoid cells. They fulfill multiple functions in regulating inflammation. The interaction between CD200/CD200R results in activation of the intracellular inhibitory pathway with RasGAP recruitment and thus contributes to effector cell inhibition. It was confirmed that the CD200R activation stimulates the differentiation of T cells to the Treg subset, upregulates indoleamine 2,3‑dioxygenase activity, modulates cytokine environment from a Th1 to a Th2 pattern, and facilitates an antiinflammatory IL‑10 and TGF‑β synthesis. CD200/CD200R are required for maintaining self‑tolerance. Many studies have demonstrated the importance of CD200 in controlling autoimmunity, inflammation, the development and spread of cancer, hypersensitivity, and spontaneous fetal loss.

  13. CD200 Expression in Neuroendocrine Neoplasms.

    Science.gov (United States)

    Love, Jason E; Thompson, Kimberly; Kilgore, Mark R; Westerhoff, Maria; Murphy, Claire E; Papanicolau-Sengos, Antonios; McCormick, Kinsey A; Shankaran, Veena; Vandeven, Natalie; Miller, Faith; Blom, Astrid; Nghiem, Paul T; Kussick, Steven J

    2017-09-01

    CD200 expression has been well studied in hematopoietic malignancies; however, CD200 expression has not been well-characterized in neuroendocrine neoplasms. We examined CD200 expression in 391 neuroendocrine neoplasms from various anatomic sites. Tissue blocks containing pulmonary small cell carcinoma, pulmonary carcinoid, large cell neuroendocrine carcinoma, pancreatic neuroendocrine tumor, gastrointestinal carcinoid, and Merkel cell carcinoma were evaluated for CD200 expression by immunohistochemistry. A set of nonneuroendocrine carcinomas was stained for comparison. CD200 was expressed in 87% of the neuroendocrine neoplasms studied, including 60 of 72 (83%) pulmonary small cell carcinomas, 15 of 22 (68%) pulmonary carcinoids, three of four (75%) pulmonary large cell neuroendocrine carcinomas, 125 of 146 (86%) Merkel cell carcinomas, 79 of 83 (95%) gastrointestinal luminal carcinoids, and 56 of 60 (93%) pancreatic neuroendocrine tumors. Thirty-two of 157 (20%) nonneuroendocrine carcinomas expressed CD200. In gastrointestinal carcinoid and pancreatic neuroendocrine neoplasms, CD200 negativity correlated with higher grade. CD200 is a relatively sensitive marker of neuroendocrine neoplasms and represents a potential therapeutic target in these difficult-to-treat malignancies.

  14. 17 CFR 200.505 - Original classification.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Original classification. 200...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Classification and Declassification of National Security Information and Material § 200.505 Original classification. (a) No Commission Member or employee has the...

  15. 24 CFR 200.17 - Mortgage coverage.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgage coverage. 200.17 Section... Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Eligible Mortgage § 200.17 Mortgage coverage. The mortgage...

  16. 24 CFR 200.87 - Mortgage prepayment.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgage prepayment. 200.87 Section... Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Mortgage Provisions § 200.87 Mortgage prepayment. (a...

  17. 24 CFR 200.15 - Maximum mortgage.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Maximum mortgage. 200.15 Section... Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Eligible Mortgage § 200.15 Maximum mortgage. Mortgages must not...

  18. 34 CFR 200.42 - Corrective action.

    Science.gov (United States)

    2010-07-01

    ... Programs Operated by Local Educational Agencies Lea and School Improvement § 200.42 Corrective action. (a... school on— (A) Revising the school improvement plan developed under § 200.41 to address the specific... corrective action; and (B) Implementing the revised improvement plan. (v) Extend for that school the length...

  19. 34 CFR 200.43 - Restructuring.

    Science.gov (United States)

    2010-07-01

    ... Programs Operated by Local Educational Agencies Lea and School Improvement § 200.43 Restructuring. (a... supplemental educational services in accordance with § 200.45. (3) Prepare a plan to carry out one of the... plan; and (B) Participate in the development of any restructuring plan. (5) Continue to comply with...

  20. 24 CFR 572.200 - Planning grants.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Planning grants. 572.200 Section...) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN....200 Planning grants. Any planning grants made by HUD under the HOPE 3 program will continue to be...

  1. 49 CFR 179.200-7 - Materials.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Materials. 179.200-7 Section 179.200-7 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS...

  2. 7 CFR 205.200 - General.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false General. 205.200 Section 205.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production...

  3. 24 CFR 200.100 - Insurance endorsement.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Insurance endorsement. 200.100... Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Endorsement § 200.100 Insurance endorsement. The...

  4. 17 CFR 200.64 - Judicial review.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Judicial review. 200.64... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.64 Judicial review. The Congress has provided for review by the courts of the decisions and orders by this Commission. Members should recognize...

  5. 13 CFR 130.200 - Eligible entities.

    Science.gov (United States)

    2010-01-01

    ... or university; (3) A college or school of business, engineering, commerce or agriculture; (4) A... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Eligible entities. 130.200 Section 130.200 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS DEVELOPMENT...

  6. FY 2002 Top 200 Users Survey Report

    Science.gov (United States)

    2002-10-01

    conducted in FY 2000, FY 2001 and FY 2002. The Customer Satisfaction Survey was a random sample of all users not included in the Top 200 Survey...contains a report on overall customer satisfaction. This is derived from the Annual Survey Composite Data Report and reflects data from both the Top 200 Users Survey and the Customer Satisfaction Survey.

  7. 24 CFR 200.73 - Property development.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Property development. 200.73 Section 200.73 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and...

  8. 17 CFR 200.114 - Sanctions.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Sanctions. 200.114 Section 200.114 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Code of Behavior Governing Ex Parte Communications Between Persons...

  9. 17 CFR 200.110 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Purpose. 200.110 Section 200.110 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Code of Behavior Governing Ex Parte Communications Between Persons...

  10. 24 CFR 200.78 - Energy conservation.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Energy conservation. 200.78 Section... Eligibility Requirements for Existing Projects Property Requirements § 200.78 Energy conservation. Construction, mechanical equipment, and energy and metering selections shall provide cost effective energy...

  11. 21 CFR 1311.200 - Pharmacy responsibilities.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Pharmacy responsibilities. 1311.200 Section 1311... ORDERS AND PRESCRIPTIONS (Eff. 6-1-10) Electronic Prescriptions § 1311.200 Pharmacy responsibilities. (a) Before initially using a pharmacy application to process controlled substance prescriptions, the pharmacy...

  12. 34 CFR 200.71 - LEA eligibility.

    Science.gov (United States)

    2010-07-01

    ... least five percent of the LEA's total population ages 5 to 17 years, inclusive. (d) Education finance... 34 Education 1 2010-07-01 2010-07-01 false LEA eligibility. 200.71 Section 200.71 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION...

  13. 17 CFR 200.71 - Fiduciary relationships.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Fiduciary relationships. 200...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.71 Fiduciary relationships. A member should avoid service as a fiduciary if it would interfere or seem to interfere with the proper...

  14. 17 CFR 200.70 - Business promotions.

    Science.gov (United States)

    2010-04-01

    ... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.70 Business promotions. A member must not engage in any other business, employment or vocation while in office, nor may he ever use the... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Business promotions. 200.70...

  15. 7 CFR 930.200 - Assessment rate.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Assessment rate. 930.200 Section 930.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TART CHERRIES GROWN IN THE STATES OF MICHIGAN, NEW YORK, PENNSYLVANIA,...

  16. 24 CFR 3.200 - Application.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Application. 3.200 Section 3.200 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE...

  17. 41 CFR 101-39.200 - Scope.

    Science.gov (United States)

    2010-07-01

    ... participating agencies. These services may be furnished through commercial rental companies, private sector... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Scope. 101-39.200 Section 101-39.200 Public Contracts and Property Management Federal Property Management Regulations System...

  18. 17 CFR 200.640 - Employment.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Employment. 200.640 Section... Programs or Activities Conducted by the Securities and Exchange Commission § 200.640 Employment. No... employment under any program or activity conducted by the agency. The definitions, requirements, and...

  19. 1996-1997 Annual Review of the 200 West and 200 East Area Performance Assessments

    Energy Technology Data Exchange (ETDEWEB)

    Wood, M. I. [Hanford Site (HNF), Richland, WA (United States)

    1998-12-22

    An annual review of the 200 West and 200 East Area Performance Assessment (PA) analyses for fiscal year 1997 was completed. Burial ground disposal operations were found to be compliant with performance objectives in DOE Order 5820.2A.

  20. 15 CFR 200.101 - Measurement research.

    Science.gov (United States)

    2010-01-01

    ..., PROCEDURES, AND FEES § 200.101 Measurement research. (a) The NIST staff continually reviews the advances in... phenomena, and uses these to devise and improve standards, measuring devices, and measurement techniques. As...

  1. 17 CFR 200.66 - Investigations.

    Science.gov (United States)

    2010-04-01

    ... ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.66 Investigations. The power to investigate... pendency of such an investigation should be made in the absence of reasonable evidence that the law has...

  2. Gogol 200 : teatraliseeritud kirjandustund / Reet Kudu

    Index Scriptorium Estoniae

    Kudu, Reet, 1949-

    2009-01-01

    4. aprillil Tallinnas Vene Kultuurikeskuses toimunud teatriõhtust "200 aastat koos Nikolai Gogoliga", mille stsenarist on Lidia Golovataja ja režissöör Jevgeni Gaitšuk. Loe ka: Kes on geeniuse sõbrad?

  3. 200 Irish students at CERN - virtually!

    CERN Multimedia

    2003-01-01

    On 6 October, 200 physics students from schools around Ireland paid a virtual visit to CERN and met several CERN scientists, with the help of the latest video conferencing technology using high-speed internet lines.

  4. Alterations in CD200-CD200R1 System during EAE Already Manifest at Presymptomatic Stages

    Directory of Open Access Journals (Sweden)

    Tony Valente

    2017-05-01

    Full Text Available In the brain of patients with multiple sclerosis, activated microglia/macrophages appear in active lesions and in normal appearing white matter. However, whether they play a beneficial or a detrimental role in the development of the pathology remains a controversial issue. The production of pro-inflammatory molecules by chronically activated microglial cells is suggested to contribute to the progression of neurodegenerative processes in neurological disease. In the healthy brain, neurons control glial activation through several inhibitory mechanisms, such as the CD200-CD200R1 interaction. Therefore, we studied whether alterations in the CD200-CD200R1 system might underlie the neuroinflammation in an experimental autoimmune encephalomyelitis (EAE model of multiple sclerosis. We determined the time course of CD200 and CD200R1 expression in the brain and spinal cord of an EAE mouse model from presymptomatic to late symptomatic stages. We also assessed the correlation with associated glial activation, inflammatory response and EAE severity. Alterations in CD200 and CD200R1 expression were mainly observed in spinal cord regions in the EAE model, mostly a decrease in CD200 and an increase in CD200R1 expression. A decrease in the expression of the mRNA encoding a full CD200 protein was detected before the onset of clinical signs, and remained thereafter. A decrease in CD200 protein expression was observed from the onset of clinical signs. By contrast, CD200R1 expression increased at EAE onset, when a glial reaction associated with the production of pro- and anti-inflammatory markers occurred, and continued to be elevated during the pathology. Moreover, the magnitude of the alterations correlated with severity of the EAE mainly in spinal cord. These results suggest that neuronal-microglial communication through CD200-CD200R1 interaction is compromised in EAE. The early decreases in CD200 expression in EAE suggest that this downregulation might also

  5. 200 North Aggregate Area source AAMS report

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This report presents the results of an aggregate area management study (AAMS) for the 200 North Aggregate Area in the 200 Areas of the US Department of Energy (DOE) Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past practice investigations.

  6. Supercapacitor Operating At 200 Degrees Celsius

    Science.gov (United States)

    Borges, Raquel S.; Reddy, Arava Leela Mohana; Rodrigues, Marco-Tulio F.; Gullapalli, Hemtej; Balakrishnan, Kaushik; Silva, Glaura G.; Ajayan, Pulickel M.

    2013-01-01

    The operating temperatures of current electrochemical energy storage devices are limited due to electrolyte degradation and separator instability at higher temperatures. Here we demonstrate that a tailored mixture of materials can facilitate operation of supercapacitors at record temperatures, as high as 200°C. Composite electrolyte/separator structures made from naturally occurring clay and room temperature ionic liquids, with graphitic carbon electrodes, show stable supercapacitor performance at 200°C with good cyclic stability. Free standing films of such high temperature composite electrolyte systems can become versatile functional membranes in several high temperature energy conversion and storage applications. PMID:23999206

  7. 17 CFR 200.2 - Statutory functions.

    Science.gov (United States)

    2010-04-01

    ... AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management § 200.2 Statutory... business, and national associations of such brokers or dealers. It gives the Commission rulemaking power... utility securities or assets or any other interest in any business, or enter into transactions with its...

  8. 17 CFR 200.54 - Constitutional obligations.

    Science.gov (United States)

    2010-04-01

    ... against any infringement of the constitutional rights, privileges, or immunities of those who are subject... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Constitutional obligations... ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.54 Constitutional...

  9. 17 CFR 200.55 - Statutory obligations.

    Science.gov (United States)

    2010-04-01

    ... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.55 Statutory obligations. In administering the law, members of this Commission should vigorously enforce compliance with the law by all... the law and be consistent with the statutory purposes expressed by the Congress. In the exercise of...

  10. 44 CFR 206.200 - General.

    Science.gov (United States)

    2010-10-01

    ... SECURITY DISASTER ASSISTANCE FEDERAL DISASTER ASSISTANCE Public Assistance Project Administration § 206.200... grants approved under the provisions of the Stafford Act. (b) What policies apply to FEMA public..., including notifications of our approvals of Project Worksheets and our estimates of when we will make...

  11. 38 CFR 51.200 - Physical environment.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Physical environment. 51...) PER DIEM FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.200 Physical environment. The... facility management must provide a safe, functional, sanitary, and comfortable environment for the...

  12. 49 CFR 1580.200 - Applicability.

    Science.gov (United States)

    2010-10-01

    ... off the general railroad system of transportation. (d) Each operator of private cars, including business/office cars and circus trains, on or connected to the general railroad system of transportation... Excursion Operators, and Private Cars § 1580.200 Applicability. This subpart includes requirements for: (a...

  13. 17 CFR 200.63 - Commission opinions.

    Science.gov (United States)

    2010-04-01

    ... Section 200.63 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT... understanding of the matter before him, avoids the suspicion of arbitrary conclusion, promotes confidence in his... should recall that he is not a repository of arbitrary power, but is acting on behalf of the public under...

  14. 24 CFR 1003.200 - General policies.

    Science.gov (United States)

    2010-04-01

    ...) OFFICE OF ASSISTANT SECRETARY FOR PUBLIC AND INDIAN HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMMUNITY DEVELOPMENT BLOCK GRANTS FOR INDIAN TRIBES AND ALASKA NATIVE VILLAGES Eligible Activities § 1003... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false General policies. 1003.200 Section...

  15. Entrance channel effect for CN 200Pb

    Directory of Open Access Journals (Sweden)

    Chavan P.B.

    2011-10-01

    Full Text Available The spin distribution of Evaporation Residues (ER was measured for the reaction 30Si + 170Er. ER spin distributions were compared for the systems 16O + 184W, 19F + 181Ta and 30Si + 170Er forming the Compound Nucleus 200Pb. Mean gamma multiplicity vs. excitation energy curve shows saturation at a lower value in case of 30Si + 170Er. This was attributed to non compound nuclear processes.

  16. Neuromuscular Fatigue During 200 M Breaststroke

    Directory of Open Access Journals (Sweden)

    Ana Conceição

    2014-03-01

    Full Text Available The aims of this study were: i to analyze activation patterns of four upper limb muscles (duration of the active and non-active phase in each lap of 200m breaststroke, ii quantify neuromuscular fatigue, with kinematics and physiologic assessment. Surface electromyogram was collected for the biceps brachii, deltoid anterior, pectoralis major and triceps brachii of nine male swimmers performing a maximal 200m breaststroke trial. Swimming speed, SL, SR, SI decreased from the 1st to the 3rd lap. SR increased on the 4th lap (35.91 ± 2.99 stroke·min-1. Peak blood lactate was 13.02 ± 1.72 mmol·l-1 three minutes after the maximal trial. The EMG average rectified value (ARV increased at the end of the race for all selected muscles, but the deltoid anterior and pectoralis major in the 1st lap and for biceps brachii, deltoid anterior and triceps brachii in the 4th lap. The mean frequency of the power spectral density (MNF decreased at the 4th lap for all muscles. These findings suggest the occurrence of fatigue at the beginning of the 2nd lap in the 200m breaststroke trial, characterized by changes in kinematic parameters and selective changes in upper limb muscle action. There was a trend towards a non-linear fatigue state.

  17. Os 200 anos da pilha elétrica The 200 years of the electric pile

    Directory of Open Access Journals (Sweden)

    Aécio Pereira Chagas

    2000-06-01

    Full Text Available In celebration of the 200th anniversary of the electric pile, invented by Alessandro Volta, a synopsis of his letter to The Royal Society (London and of his biography is presented.

  18. STUDY OF 200 CASES OF PLEURAL FLUID

    Directory of Open Access Journals (Sweden)

    Ramakrishna R

    2016-09-01

    Full Text Available BACKGROUND We have studied 200 patients of pleural fluid presenting to our tertiary care centre. Presence of cases of pleural fluid is a common presentation both in pulmonary and extrapulmonary diseases. We analysed the patients having both exudates and transudates and studied the results. MATERIALS AND METHODS We selected patients above 20 years of age and classified the patients with pleural fluid as having transudates and exudates. We studied the causes of transudates and exudates. A total of 200 patients are studied in this prospective study. Diagnosis of pleural exudates is made on the basis of Light’s criteria, chest x-ray, pleural fluid analysis, CT scan in selected patients, sputum examination, bronchoscopy and bronchial washings. Moribund and non-cooperative patients and HIV positives were excluded from the study. RESULTS Among the 200 patients, 91% have exudates. 9% have transudates by Light’s criteria. Tuberculosis is the commonest cause of effusions (64.83% followed by malignancy (13.73% and sympneumonic or parapneumonic effusions (9.89%. Pleural effusions occurred predominantly in males. Prevalence of diabetes Mellitus among cases of tuberculous pleural effusions is 13.56%. Tuberculous effusions are predominantly right-sided. CONCLUSION Predominant cases of pleural fluid are exudates. Commonest cause of pleural effusion is Tuberculosis followed by malignancy both pulmonary and extrapulmonary and sym. and parapneumonic effusions. Prevalence of Diabetes among Tuberculous pleural effusion cases is more or less same as in general population. Cough, expectoration fever, chest pain and breathlessness are the common symptoms occurring in three fourths of the patients of tuberculous pleural effusion. Most of the cases of Tuberculous effusion are above 30 years of age. In the diagnosis of tuberculous pleural effusion, Pleural fluid ADA is very important. Pleural fluid cytology, pleural biopsy, bronchoscopy, bronchial washings and sputum

  19. 13 CFR 108.200 - Adequate capital for NMVC Companies.

    Science.gov (United States)

    2010-01-01

    ... Companies. 108.200 Section 108.200 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Qualifications for the NMVC Program Capitalizing A Nmvc Company § 108.200 Adequate capital for NMVC Companies. You must meet the requirements of §§ 108.200-108.230 in order to...

  20. Superhigh-resolution 200ppi series TFT-LCDs; Chokoseisai 200ppi ekisho display series

    Energy Technology Data Exchange (ETDEWEB)

    Kawamata, K.; Hirai, H. [Toshiba Corp., Tokyo (Japan)

    2000-02-01

    We have developed a 202 pixels per inch (ppi) thin-film transistor liquid crystal display (TFT-LCD) using low-temperature polycrystalline silicon (LTPS) technology. The superhigh resolution of 202 ppi offers the same image quality as printed matter such as magazines. The 200 ppi series TFT-LCDs are expected to support further developments in such areas as electronic books (e-books) and personal digital-picture viewers. Our lineup of 200 ppi TFT-LCDs includes a 4-inch display with VGA resolution, which is suitable for palmtop-size applications, and a 6.3-inch display with XGA resolution, which is suitable for typical photograph or paperback book-size applications. Larger size LCDs with 200 ppi resolution will be developed. (author)

  1. 200 kg space payload recovery system

    Science.gov (United States)

    Doherr, Karl-Friedrich; Norrvi, Olle; Pepper, William B.

    For the recovery of a 200 kg space payload from 800 km altitude a parachute system with minimal weight was to be designed. The allowed parachute mass (without parachute canister) was 7 kg, the maximum impact velocity 8 m/s. This required the partial use of Kevlar as a high strength/low weight material. Also, two parachute systems were considered: (1) a conventional system consisting of a conical ribbon drogue chute and a very light cross main chute; and (2) an alternative system consisting of rotating parachutes with high drag coefficient. In a next step flight tests are planned with a rotating parachute as the drogue and a cross canopy as the main parachute.

  2. Elevated serum soluble CD200 and CD200R as surrogate markers of bone loss under bed rest conditions.

    Science.gov (United States)

    Kos, O; Hughson, R L; Hart, D A; Clément, G; Frings-Meuthen, P; Linnarsson, D; Paloski, W H; Rittweger, J; Wuyts, F; Zange, J; Gorczynski, R M

    2014-03-01

    CD200 is a transmembrane protein that belongs to the immunoglobulin family of proteins and is ubiquitously expressed on a variety of cell types. Upon interaction with its receptors (CD200Rs) expressed on myeloid-derived cells and T lymphocytes, an immunoregulatory signal is delivered to receptor-expressing cells. Previous studies have implicated a role for CD200:CD200R in the regulation of the expression of mRNA markers of osteoclastogenesis/osteoblastogenesis, following interaction of CD200 (on osteoblast precursors) with CD200R1 (on osteoclast precursors). Signaling of CD200R1 is hypothesized to attenuate osteoclastogenesis. We have investigated whether levels of soluble forms of CD200 and/or CD200R1 (sCD200, sCD200R1) are altered in volunteers undergoing 6° head down tilt bed rest to mimic conditions of microgravity known to be associated with preferential osteoclastogenesis and whether countermeasures, reported to be beneficial in attenuation of bone loss under microgravity conditions, would lead to altered sCD200 and sCD200R1 levels. Our data suggest that, as predicted, sCD200 levels fall under bed rest conditions while sCD200R1 levels rise. In subjects undergoing 30-minute per day continuous centrifugation protocols, as a countermeasure to attenuate changes which may lead to bone loss, these alterations in sCD200 and sCD200R1 levels seen under conditions of bed rest were abolished or attenuated. Our results suggest that measurement of sCD200 and/or sCD200R1 may prove a useful and rapid means of monitoring subjects at risk of bone loss and/or accessing the efficacy of treatment regimes designed to counter bone loss. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. Earth Surface Patterns in 200 Years (Invited)

    Science.gov (United States)

    Werner, B.

    2009-12-01

    What kinds of patterns will characterize Earth's surface in 200 years? This question is addressed using a complex systems dynamical framework for distinct levels of description in a hierarchy, in which time scale and spatial extent increase and number of variables decrease with level, and in which levels are connected nonlinearly to each other via self-organization and slaving and linearly to the external environment. Self-organized patterns linking the present to 200 years in the future must be described dynamically on a level with a time scale of centuries. Human-landscape coupling will play a prominent role in the formation of these patterns as population peaks and interactions become nonlinear over these time scales. Three related examples illustrate this approach. First, the response of human-occupied coastlines to rising sea level. Coastlines in wealthy regions develop a spatially varying boom and bust pattern, with response amplified by structures meant to delay the effects of sea level rise. Coastlines in economically disadvantaged regions experience a subdued response, with populations developing a culture of displacement that minimizes human-landscape interactions in a context of scarce resources. Second, the evolution of nation-state borders with degrading ecosystems, declining resource availability and increasing transportation costs. The maintenance of strong borders as selective filtration systems (goods, capital and people) is based on a cost-benefit analysis in which the economic benefits accruing from long distance, globalized resource exploitation are weighed against policing and infrastructure costs. As costs rise above benefits, borders fragment, with a transition to local barriers and conflicts, and mobile peoples moving to resources. Third, trends in urbanization and development of megacities under economic and environmental stress. The pattern of rapid growth of megacities through inward migration, with displaced people occupying high

  4. Chirped Pulse Spectrometer Operating at 200 GHz

    Science.gov (United States)

    Hindle, Francis; Bray, Cédric; Hickson, Kevin; Fontanari, Daniele; Mouelhi, Meriem; Cuisset, Arnaud; Mouret, Gaël; Bocquet, Robin

    2017-10-01

    The combination of electronic sources operating at high frequencies and modern microwave instrumentation has enabled the recent development of chirped pulse spectrometers for the millimetre and THz bands. This type of instrument can operate at high resolution which is particularly suited to gas-phase rotational spectroscopy. The construction of a chirped pulse spectrometer operating at 200 GHz is described in detail while attention is paid to the phase stability and the data accumulation over many cycles. Validation using carbonyl sulphide has allowed the detection limit of the instrument to be established as function of the accumulation. A large number of OCS transitions were identified using a 10-GHz chirped pulse and include the six most abundant isotopologues, the weakest line corresponding to the fundamental R(17) transition of 16O13C33S with a line strength of 4.3 × 10-26 cm-1/(molecule cm-2). The linearity of the system response for different degrees of data accumulation and transition line strength was confirmed over four orders of magnitudes. A simple analysis of the time-domain data was demonstrated to provide the line-broadening coefficient without the need for conversion by a Fourier transform. Finally, the pulse duration is discussed and optimal values are given for both Doppler-limited and collisional regimes.

  5. A 200-year history of Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Xiao-dan WANG

    2017-01-01

    Full Text Available In 1817, Dr. James Parkinson firstly described the concept, duration, and clinical characteristics of Parkinson's disease (PD. However, it was widely known until 1877 when it was named "Parkinson's disease" by Dr. Jean-Martin Charcot. In 1912, Frederic Henry Lewy, a neuropathologist, found a special abnormal protein in nerve cells of PD patients. Medical profession began to learn about the pathology of PD only when Konstantin Tretiakoff named the special abnormal protein "Lewy body (LB" in 1919 and believed the main lesion of PD was in substantia nigra. In 1867, the German psychiatrist Leopold Ordenstein found that PD patients had symptoms of excitement of parasympathetic nerve, such as salivation, and treated them with belladonna alkaloids, thus creating a precedent for medical treatment of PD. After 1950's, the researchers gradually found that Lewy body was common in substantia nigra and locus coeruleus of PD patients and then gradually determined the pathological features of PD. The Swedish scientist Arvid Carlsson and Japanese neurologist Isamu Sano found dopamine abnormalities in the brain of PD patients, and thus researched and developed levodopa. PD has a history of 200 years, and we expect new research of PD studies. DOI: 10.3969/j.issn.1672-6731.2017.01.002

  6. 40 CFR 246.200 - High-grade paper recovery.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false High-grade paper recovery. 246.200 Section 246.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES SOURCE... paper recovery. ...

  7. 19 CFR 200.735-103 - Counseling service.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Counseling service. 200.735-103 Section 200.735-103 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION EMPLOYEE RESPONSIBILITIES AND CONDUCT General Provisions § 200.735-103 Counseling service. (a) The Chairman shall appoint a Designated Agency...

  8. 34 CFR 200.19 - Other academic indicators.

    Science.gov (United States)

    2010-07-01

    ..., consistent with § 200.14(e), each State must use at least one other academic indicator for public elementary... 34 Education 1 2010-07-01 2010-07-01 false Other academic indicators. 200.19 Section 200.19... EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Improving...

  9. 40 CFR 240.200 - Solid wastes accepted.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Solid wastes accepted. 240.200 Section 240.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures § 240.200 Solid...

  10. 49 CFR 613.200 - Statewide transportation planning and programming.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Statewide transportation planning and programming. 613.200 Section 613.200 Transportation Other Regulations Relating to Transportation (Continued... Transportation Planning and Programming § 613.200 Statewide transportation planning and programming. The...

  11. 17 CFR 200.735-7 - Negotiation for employment.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Negotiation for employment. 200.735-7 Section 200.735-7 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Employees and Former Members and Employees of the Commission § 200.735-7 Negotiation for employment. (a) An...

  12. 40 CFR 246.200-7 - Recommended procedures: Transportation.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommended procedures: Transportation. 246.200-7 Section 246.200-7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... § 246.200-7 Recommended procedures: Transportation. Transportation to market may be supplied by the...

  13. 34 CFR 200.41 - School improvement plan.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false School improvement plan. 200.41 Section 200.41... Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.41 School improvement plan. (a)(1) Not later than three months after an LEA has identified a school for improvement...

  14. 34 CFR 200.44 - Public school choice.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Public school choice. 200.44 Section 200.44 Education... Programs Operated by Local Educational Agencies Lea and School Improvement § 200.44 Public school choice... enrolled in the school with the option to transfer to another public school served by the LEA. (2) The LEA...

  15. 34 CFR 200.91 - SEA counts of eligible children.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false SEA counts of eligible children. 200.91 Section 200.91... Prevention and Intervention Programs for Children and Youth Who are Neglected, Delinquent, or At-Risk of Dropping Out § 200.91 SEA counts of eligible children. To receive an allocation under part D, subpart 1 of...

  16. 17 CFR 200.26a - Office of Information Technology.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Office of Information Technology. 200.26a Section 200.26a Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Organization § 200.26a Office of Information Technology. The Office of Information Technology is responsible...

  17. 20 CFR 637.200 - Allotments to States.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Allotments to States. 637.200 Section 637.200 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROGRAMS UNDER TITLE V OF THE JOB TRAINING PARTNERSHIP ACT Program Planning and Operation § 637.200 Allotments to States. (a...

  18. 7 CFR 948.200 - Accounting and collections.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Accounting and collections. 948.200 Section 948.200 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Accounting and Collections § 948.200 Accounting and collections. (a) Each handler's assessment account with...

  19. 29 CFR 2530.200b-6 - Maritime industry.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Maritime industry. 2530.200b-6 Section 2530.200b-6 Labor... Provisions § 2530.200b-6 Maritime industry. (a) General. Sections 202(a)(3)(D), 203(b)(2)(D) and 204(b)(3)(E... provisions applicable to the maritime industry. In general, those provisions permit statutory standards...

  20. 36 CFR 223.200 - Determinations of surplus species.

    Science.gov (United States)

    2010-07-01

    ... species. 223.200 Section 223.200 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... Relief Act of 1990 Program § 223.200 Determinations of surplus species. (a) Determinations that specific quantities of grades and species are surplus to domestic manufacturing needs and withdrawals of such...

  1. 17 CFR 200.507 - Declassification dates on derivative documents.

    Science.gov (United States)

    2010-04-01

    ... derivative documents. 200.507 Section 200.507 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... of National Security Information and Material § 200.507 Declassification dates on derivative... derivative document that derives its classification from the approved use of the classification guide of...

  2. 34 CFR 200.12 - Single State accountability system.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Single State accountability system. 200.12 Section 200... Improving Basic Programs Operated by Local Educational Agencies State Accountability System § 200.12 Single State accountability system. (a)(1) Each State must demonstrate in its State plan that the State has...

  3. 24 CFR 200.36 - Financial reporting requirements.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Financial reporting requirements. 200.36 Section 200.36 Housing and Urban Development Regulations Relating to Housing and Urban... Regulations § 200.36 Financial reporting requirements. The mortgagor must comply with the financial reporting...

  4. 21 CFR 11.200 - Electronic signature components and controls.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Electronic signature components and controls. 11.200 Section 11.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ELECTRONIC RECORDS; ELECTRONIC SIGNATURES Electronic Signatures § 11.200 Electronic...

  5. 200 area effluent treatment facility opertaional test report

    Energy Technology Data Exchange (ETDEWEB)

    Crane, A.F.

    1995-10-26

    This document reports the results of the 200 Area Effluent Treatment Facility (200 Area ETF) operational testing activities. These Operational testing activities demonstrated that the functional, operational and design requirements of the 200 Area ETF have been met and identified open items which require retesting.

  6. Improving flexibility characteristics of 200 MW unit

    Directory of Open Access Journals (Sweden)

    Taler Jan

    2017-03-01

    Full Text Available Calculations were performed of the thermal system of a power plant with installed water pressure tanks. The maximum rise in the block electric power resulting from the shut-off of low-pressure regenerative heaters is determined. At that time, the boiler is fed with hot water from water pressure tanks acting as heat accumulators. Accumulation of hot water in water tanks is also proposed in the periods of the power unit small load. In order to lower the plant electric power in the off-peak night hours, water heated in low-pressure regenerative heaters and feed water tank to the nominal temperature is directed to water pressure tanks. The water accumulated during the night is used to feed the boiler during the period of peak demand for electricity. Drops in the power block electric power were determined for different capacities of the tanks and periods when they are charged. A financial and economic profitability analysis (of costs and benefits is made of the use of tanks for a 200 MW power unit. Operating in the automatic system of frequency and power control, the tanks may also be used to ensure a sudden increase in the electric power of the unit. The results of the performed calculations and analyses indicate that installation of water pressure tanks is well justified. The investment is profitable. Water pressure tanks may not only be used to reduce the power unit power during the off-peak night hours and raise it in the periods of peak demand, but also to increase the power capacity fast at any time. They may also be used to fill the boiler evaporator with hot water during the power unit start-up from the cold state.

  7. Improving flexibility characteristics of 200 MW unit

    Science.gov (United States)

    Taler, Jan; Trojan, Marcin; Taler, Dawid; Dzierwa, Piotr; Kaczmarski, Karol

    2017-03-01

    Calculations were performed of the thermal system of a power plant with installed water pressure tanks. The maximum rise in the block electric power resulting from the shut-off of low-pressure regenerative heaters is determined. At that time, the boiler is fed with hot water from water pressure tanks acting as heat accumulators. Accumulation of hot water in water tanks is also proposed in the periods of the power unit small load. In order to lower the plant electric power in the off-peak night hours, water heated in low-pressure regenerative heaters and feed water tank to the nominal temperature is directed to water pressure tanks. The water accumulated during the night is used to feed the boiler during the period of peak demand for electricity. Drops in the power block electric power were determined for different capacities of the tanks and periods when they are charged. A financial and economic profitability analysis (of costs and benefits) is made of the use of tanks for a 200 MW power unit. Operating in the automatic system of frequency and power control, the tanks may also be used to ensure a sudden increase in the electric power of the unit. The results of the performed calculations and analyses indicate that installation of water pressure tanks is well justified. The investment is profitable. Water pressure tanks may not only be used to reduce the power unit power during the off-peak night hours and raise it in the periods of peak demand, but also to increase the power capacity fast at any time. They may also be used to fill the boiler evaporator with hot water during the power unit start-up from the cold state.

  8. PM200/PS200: Self-Lubricating Bearing and Seal Materials for Applications to 900 C

    Science.gov (United States)

    Sliney, Harold E.

    1991-01-01

    The development of the PS/PM200 class of self-lubricating material is described. The composition of the materials and their performance under temperature conditions from minus 160 degrees to 900 C (minus 250 to 1650 F) are examined. Applications in areas such as cylinder liner coatings, shaft seals, gas bearings, and airframe thermal expansion joints are proposed. Graphs and tables are provided to show service temperature limits, mechanical strength, linear thermal expansion, and thermal conductivity parameters.

  9. CD200:CD200R Interactions Regulate Osteoblastogenesis and Osteoclastogenesis in Space

    Science.gov (United States)

    Kos, Olha; Lee, Lydia; Gorezynski, Reginald M.

    2008-06-01

    We report data from studies on a recent FOTON mission, using an eOSTEO cell culture system developed by Systems Technologies Canada Inc., showing that in space overexpression of CD200 (using cell cultures derived from transgenic mice expressing CD200 under control of a doxycycline-inducible promoter) is associated with an attenuation in the suppression of mRNA markers of osteoblastogeneis (including BSP, OPG) with concomitant loss of the preferential increased osteoclastogenesis which is otherwise seen in the absence of CD200. In separate cultures we also explored the additional effect of altered inflammatory cytokines on the perturbation of expression of these bone-related genes, using cells from cytokine-receptor knockout mice. Our data suggest that while exogenous inflammatory cytokines (TNFα+IL1β) increased mRNAs typical for osteoclastogenesis under ground conditions, they appeared to produce no further modification of mRNA expression in flight. We suggest that altered mRNA expression in flight is not primarily driven by altered expression of inflammatory cytokines.

  10. 200-BP-5 operable unit treatability test report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    The 200-BP-5 Operable Unit was established in response to recommendations presented in the 200 East Groundwater Aggregate Area Management Study Report (AAMSR) (DOE-RL 1993a). Recognizing different approaches to remediation, the groundwater AAMSR recommended separating groundwater from source and vadose zone operable units and subdividing 200 East Area groundwater into two operable units. The division between the 200-BP-5 and 200-PO-1 Operable Units was based principally on source operable unit boundaries and distribution of groundwater plumes derived from either B Plant or Plutonium/Uranium Extraction (PUREX) Plant liquid waste disposal sites.

  11. Super high precision 200 ppi liquid crystal display series; Chokoseido 200 ppi ekisho display series

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    In mobile equipment, in demand is a high precision liquid crystal display (LCD) having the power of expression equivalent to printed materials like magazines because of the necessity of displaying a large amount of information on a easily potable small screen. In addition, with the spread and high-quality image of digital still cameras, it is strongly desired to display photographed digital image data in high quality. Toshiba Corp., by low temperature polysilicone (p-Si) technology, commercialized the liquid crystal display series of 200 ppi (pixels per inch) precision dealing with the rise of the high-precision high-image quality LCD market. The super high precision of 200 ppi enables the display of smooth beautiful animation comparable to printed sheets of magazines and photographs. The display series are suitable for the display of various information services such as electronic books and electronic photo-viewers including internet. The screen sizes lined up are No. 4 type VGA (640x480 pixels) of a small pocket notebook size and No. 6.3 type XGA (1,024x768 pixels) of a paperback size, with a larger screen to be furthered. (translated by NEDO)

  12. 29 CFR 2530.200b-1 - Computation periods.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Computation periods. 2530.200b-1 Section 2530.200b-1 Labor... Provisions § 2530.200b-1 Computation periods. (a) General. Under sections 202, 203 and 204 of the Act and... specified period—in general, a twelve-consecutive-month period—referred to herein as a “computation period...

  13. 1 GHz, 200 C, SiC MESFET Clapp Oscillator

    Science.gov (United States)

    Ponchak, George E.; Schwartz, Zachary D.

    2005-01-01

    A SiC Clapp oscillator frabricated on an alumina substrate with chip capacitors and spiral inductors is designed for high temperature operation at 1 gigahertz. The oscillator operated from 30 to 200 C with an output power of 21.8 dBm at 1 gigahertz and 200 C. The efficiency at 200 C is 15 percent. The frequency variation over the temperature range is less than 0.5 percent.

  14. 21 CFR 522.1125 - Hemoglobin glutamer-200 (bovine).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Hemoglobin glutamer-200 (bovine). 522.1125 Section... § 522.1125 Hemoglobin glutamer-200 (bovine). (a) Specifications. Each 125 milliliter bag contains 13 grams per deciliter of polymerized hemoglobin of bovine origin in modified Lactated Ringer's Solution...

  15. 34 CFR 200.6 - Inclusion of all students.

    Science.gov (United States)

    2010-07-01

    ... academic achievement standards the State has defined under § 200.1(d). (iii) If a State permits the use of... EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Improving... students. A State's academic assessment system required under § 200.2 must provide for the participation of...

  16. 34 CFR 200.18 - Annual measurable objectives.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Annual measurable objectives. 200.18 Section 200.18... EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Improving... measurable objectives. (a) Each State must establish annual measurable objectives that— (1) Identify for each...

  17. 24 CFR 200.21 - Reinsurance of Commissioner held mortgages.

    Science.gov (United States)

    2010-04-01

    ... mortgages. 200.21 Section 200.21 Housing and Urban Development Regulations Relating to Housing and Urban..., Commitment, and Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Miscellaneous Project Mortgage...

  18. 24 CFR 200.34 - Property and mortgage assessment.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Property and mortgage assessment..., Commitment, and Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance... Regulations § 200.34 Property and mortgage assessment. The requirements set forth in 24 CFR part 200, subpart...

  19. 24 CFR 200.20 - Refinancing insured mortgages.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Refinancing insured mortgages. 200... Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Miscellaneous Project Mortgage Insurance § 200.20...

  20. 34 CFR 200.34 - Identification for restructuring.

    Science.gov (United States)

    2010-07-01

    ... Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.34 Identification... corrective action under § 200.42, the LEA must prepare a restructuring plan for the school and make arrangements to implement the plan. (b) If the school continues to fail to make AYP, the LEA must implement the...

  1. 17 CFR 200.61 - Impressions of influence.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Impressions of influence. 200...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.61 Impressions of influence. A... influence him, that any person unduly enjoys his favor or that he is affected in any way by the rank...

  2. 34 CFR 303.200 - Formula for State allocations.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Formula for State allocations. 303.200 Section 303.200 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND...

  3. 9 CFR 590.200 - Records and related requirements.

    Science.gov (United States)

    2010-01-01

    ....200 Section 590.200 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... and related requirements. (a) Persons engaged in the business of transporting, shipping, or receiving... concerned therewith, the receipt, delivery, sale, movement, and disposition of all eggs and egg products...

  4. 24 CFR 200.800 - Lead-based paint.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Lead-based paint. 200.800 Section... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Lead-Based Paint Poisoning Prevention § 200.800 Lead-based paint. The Lead-Based Paint Poisoning Prevention Act (42 U.S.C. 4821-4846), the Residential Lead-Based...

  5. 21 CFR 573.200 - Condensed animal protein hydrolysate.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Condensed animal protein hydrolysate. 573.200... ANIMALS Food Additive Listing § 573.200 Condensed animal protein hydrolysate. (a) Identity. The condensed animal protein hydrolysate is produced from the meat byproducts scraped from cured (salted) hides taken...

  6. 29 CFR 1926.200 - Accident prevention signs and tags.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 8 2010-07-01 2010-07-01 false Accident prevention signs and tags. 1926.200 Section 1926... § 1926.200 Accident prevention signs and tags. (a) General. Signs and symbols required by this subpart... principal stroke of the letters shall be at least three-fourths inch in width. (e) Safety instruction signs...

  7. 13 CFR 107.200 - Adequate capital for Licensees.

    Science.gov (United States)

    2010-01-01

    ... operate actively in accordance with your Articles and within the context of your business plan, as... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Adequate capital for Licensees. 107.200 Section 107.200 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS...

  8. 34 CFR 200.61 - Parents' right to know.

    Science.gov (United States)

    2010-07-01

    ..., and the field of discipline of the certification or degree. (4) Whether the child is provided services... parent's child has been assigned, or has been taught for four or more consecutive weeks by, a teacher of... 34 Education 1 2010-07-01 2010-07-01 false Parents' right to know. 200.61 Section 200.61 Education...

  9. 17 CFR 200.67 - Power to adopt rules.

    Science.gov (United States)

    2010-04-01

    ... rules should never tend to stifle or discourage legitimate business enterprises or activities, nor... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Power to adopt rules. 200.67... AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.67 Power to adopt rules. In exercising...

  10. 7 CFR 1900.157-1900.200 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false 1900.157-1900.200 Section 1900.157-1900.200 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE PROGRAM...

  11. 21 CFR 155.200 - Certain other canned vegetables.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Certain other canned vegetables. 155.200 Section 155.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CANNED VEGETABLES Requirements for Specific Standardized Canned...

  12. 34 CFR 200.60 - Expenditures for professional development.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Expenditures for professional development. 200.60... Paraprofessionals § 200.60 Expenditures for professional development. (a)(1) Except as provided in paragraph (a)(2... professional development activities to ensure that teachers and paraprofessionals meet the requirements of...

  13. 17 CFR 200.21a - The Ethics Counsel.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false The Ethics Counsel. 200.21a...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General Organization § 200.21a The Ethics Counsel. (a) The Ethics Counsel within the Office of the General Counsel of the...

  14. 7 CFR 1437.108-1437.200 - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false 1437.108-1437.200 Section 1437.108-1437.200 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS NONINSURED CROP DISASTER ASSISTANCE PROGRAM...

  15. 24 CFR 200.218 - Who must certify and sign.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Who must certify and sign. 200.218... Previous Participation Review and Clearance Procedure § 200.218 Who must certify and sign. All principals must certify and sign the certificate personally as to their individual record and are responsible for...

  16. 40 CFR 52.200 - Original identification of plan section.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Original identification of plan section. 52.200 Section 52.200 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... were held was submitted by the State Department of Pollution Control and Ecology on January 25, 1972...

  17. 17 CFR 200.57 - Relationships with other members.

    Science.gov (United States)

    2010-04-01

    ... members. 200.57 Section 200.57 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... other members. Each member should recognize that his conscience and those of other members are distinct... commission type of administration. However, a member should never permit his personal opinion so to conflict...

  18. 49 CFR 572.200 - Instrumentation and test conditions.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Instrumentation and test conditions. 572.200... Side Impact Crash Test Dummy, Small Adult Female § 572.200 Instrumentation and test conditions. (a) The...) Instrumentation and sensors conform to the Recommended Practice SAE J-211 (March 1995), Instrumentation for Impact...

  19. Exceptional results from, and status of, EXO-200

    Science.gov (United States)

    Smith, Erica; EXO-200 Collaboration

    2015-10-01

    EXO-200 has provided one of the most sensitive searches for neutrinoless double-beta decay utilizing 175 kg of enriched liquid xenon in an ultra-low background time projection chamber. This detector has demonstrated excellent energy resolution and background rejection capabilities. Using the first two years of data, EXO-200 has set a limit of 1 . 1 ×1025 y at 90% C.L. on the neutrinoless double-beta decay half-life of Xe136. The experiment has experienced a brief hiatus in data taking during a temporary shutdown of its host facility: the Waste Isolation Pilot Plant. EXO-200 expects to resume data taking in earnest this fall with upgraded detector electronics. Results from the analysis of EXO-200 data and an update on the current status of EXO-200 will be presented.

  20. Waste site grouping for 200 Areas soil investigations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-01-01

    The purpose of this document is to identify logical waste site groups for characterization based on criteria established in the 200 Areas Soil Remediation Strategy (DOE-RL 1996a). Specific objectives of the document include the following: finalize waste site groups based on the approach and preliminary groupings identified in the 200 Areas Soil Remediation Strategy; prioritize the waste site groups based on criteria developed in the 200 Areas Soil Remediation Strategy; select representative site(s) that best represents typical and worse-case conditions for each waste group; develop conceptual models for each waste group. This document will serve as a technical baseline for implementing the 200 Areas Soil Remediation Strategy. The intent of the document is to provide a framework, based on waste site groups, for organizing soil characterization efforts in the 200 Areas and to present initial conceptual models.

  1. miR-200 Regulates Endometrial Development During Early Pregnancy

    Science.gov (United States)

    Mainigi, Monica A.; Word, R. Ann; Kraus, W. Lee; Mendelson, Carole R.

    2016-01-01

    For successful embryo implantation, endometrial stromal cells must undergo functional and morphological changes, referred to as decidualization. However, the molecular mechanisms that regulate implantation and decidualization are not well defined. Here we demonstrate that the estradiol- and progesterone-regulated microRNA (miR)-200 family was markedly down-regulated in mouse endometrial stromal cells prior to implantation, whereas zinc finger E-box binding homeobox-1 and -2 and other known and predicted targets were up-regulated. Conversely, miR-200 was up-regulated during in vitro decidualization of human endometrial stromal cells. Knockdown of miR-200 negatively affected decidualization and prevented the mesenchymal-epithelial transition-like changes that accompanied decidual differentiation. Notably, superovulation of mice and humans altered miR-200 expression. Our findings suggest that hormonal alterations that accompany superovulation may negatively impact endometrial development and decidualization by causing aberrant miR-200 expression. PMID:27533790

  2. Tier II Analysis of Vadose Zone Sediments from UPRS 200-E-81 and 200-E-86

    Energy Technology Data Exchange (ETDEWEB)

    Valenta, Michelle M.; Geiszler, Keith N.; Bjornstad, Bruce N.; Schaef, Herbert T.; Brown, Christopher F.

    2009-04-01

    The overall goals of the Tank Farm Vadose Zone Project, led by Washington River Protection Solutions, are to define risks from past and future single-shell tank farm activities; identify and evaluate the efficacy of interim measures; and aid, via collection of geochemical information and data, the future decisions that must be made by the U.S. Department of Energy (DOE) regarding the near-term operations, future waste retrieval, and final closure activities for the single-shell tank waste management areas (WMAs). To meet the investigative goals of the Tank Farm Vadose Zone Project, the Environmental Sciences Laboratory performed geochemical analyses on vadose zone sediments collected within Waste Management Area C. Tier one analyses of UPR-200-E-86, which includes direct push probe holes C5952, C5958 and C5960, were performed between 3/25/08 and 4/14/08. Preliminary results were presented to CH2M Hill Hanford Group on 6/5/08. As a result of the tier one investigations, further tier two analyses were requested. Tier two investigations include particle size and mineralogy analyses on samples collected between 80 to 120 feet below ground surface that were found to contain high concentrations of chloride and sulfate. Tier one analyses on sediments retrieved near UPR-200-E-81, direct push probe hole C6394, were performed between 6/20/08 and 7/22/08. Preliminary results of the tier one analyses were presented on 8/15/08. As a result of the tier one investigations, further tier two analyses were requested. Tier two analyses include determining whether U-236 exists in samples at approximately 42 feet below the ground surface. Confirmation of U-236 will determine whether the U-238 seen in the leaches performed on samples at that depth is a result of contamination and not from leaching natural uranium. Using the water and acid extract U-238 concentrations from the tier one analysis, equilibrium Kd values were requested to be calculated. Additional tier two analysis includes

  3. 75 FR 9137 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Science.gov (United States)

    2010-03-01

    ... specified in Boeing 737 Standard Overhaul Practices Manual, Chapter 20-42-09, Revision 25, dated July 1... all The Boeing Company Model 737-100, - 200, -200C, -300, -400, and -500 series airplanes... Instructions'' of Boeing Alert Service Bulletin 737-57A1277, Revision 1, dated November 25, 2003. Work Package...

  4. 76 FR 63229 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Science.gov (United States)

    2011-10-12

    ... Limitations and Normal Procedures sections of the applicable Boeing 737 Airplane Flight Manual (AFM) to advise... Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500 Series Airplanes AGENCY... the airplane. Relevant Service Information We have reviewed Boeing Alert Service Bulletin 737-28A1216...

  5. 21 CFR 200.200 - Prescription drugs; reminder advertisements and reminder labeling to provide price information to...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Prescription drugs; reminder advertisements and... Prescription Drug Consumer Price Listing § 200.200 Prescription drugs; reminder advertisements and reminder labeling to provide price information to consumers. (a) Prescription drug reminder advertisements and...

  6. CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Zhang Shi

    2011-11-01

    Full Text Available Abstract Background Increasing evidence suggests that microglial activation may participate in the aetiology and pathogenesis of Parkinson's disease (PD. CD200-CD200R signalling has been shown to be critical for restraining microglial activation. We have previously shown that expression of CD200R in monocyte-derived macrophages, induced by various stimuli, is impaired in PD patients, implying an intrinsic abnormality of CD200-CD200R signalling in PD brain. Thus, further in vivo evidence is needed to elucidate the role of malfunction of CD200-CD200R signalling in the pathogenesis of PD. Methods 6-hydroxydopamine (6-OHDA-lesioned rats were used as an animal model of PD. CD200R-blocking antibody (BAb was injected into striatum to block the engagement of CD200 and CD200R. The animals were divided into three groups, which were treated with 6-OHDA/Veh (PBS, 6-OHDA/CAb (isotype control antibody or 6-OHDA/BAb, respectively. Rotational tests and immunohistochemistry were employed to evaluate motor deficits and dopaminergic neurodegeneration in animals from each group. HPLC analysis was used to measure monoamine levels in striatum. Morphological analysis and quantification of CD11b- (or MHC II- immunoreactive cells were performed to investigate microglial activation and possible neuroinflammation in the substantia nigra (SN. Finally, ELISA was employed to assay protein levels of proinflammatory cytokines. Results Compared with 6-OHDA/CAb or 6-OHDA/Veh groups, rats treated with 6-OHDA/BAb showed a significant increase in counts of contralateral rotation and a significant decrease in TH-immunoreactive (TH-ir neurons in SN. A marked decrease in monoamine levels was also detected in 6-OHDA/BAb-treated rats, in comparison to 6-OHDA/Veh-treated ones. Furthermore, remarkably increased activation of microglia as well as up-regulation of proinflammatory cytokines was found concomitant with dopaminergic neurodegeneration in 6-OHDA/BAb-treated rats. Conclusions This

  7. CD200R/CD200 inhibits osteoclastogenesis: new mechanism of osteoclast control by mesenchymal stem cells in human.

    Directory of Open Access Journals (Sweden)

    Audrey Varin

    Full Text Available Bone homeostasis is maintained by the balance between bone-forming osteoblasts and bone-degrading osteoclasts. Osteoblasts have a mesenchymal origin whereas osteoclasts belong to the myeloid lineage. Osteoclast and osteoblast communication occurs through soluble factors secretion, cell-bone interaction and cell-cell contact, which modulate their activities. CD200 is an immunoglobulin superfamilly member expressed on various types of cells including mesenchymal stem cells (MSCs. CD200 receptor (CD200R is expressed on myeloid cells such as monocytes/macrophages. We assume that CD200 could be a new molecule involved in the control of osteoclastogenesis and could play a role in MSC-osteoclast communication in humans. In this study, we demonstrated that soluble CD200 inhibited the differentiation of osteoclast precursors as well as their maturation in bone-resorbing cells in vitro. Soluble CD200 did not modify the monocyte phenotype but inhibited the receptor activator of nuclear factor kappa-B ligand (RANKL signaling pathway as well as the gene expression of osteoclast markers such as osteoclast-associated receptor (OSCAR and nuclear factor of activated T cells cytoplasmic 1 (NFATc1. Moreover, MSCs inhibited osteoclast formation, which depended on cell-cell contact and was associated with CD200 expression on the MSC surface. Our results clearly demonstrate that MSCs, through the expression of CD200, play a major role in the regulation of bone resorption and bone physiology and that the CD200-CD200R couple could be a new target to control bone diseases.

  8. 1992 County Pesticide Use Estimates for 200 Compounds

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset includes information for 200 pesticides on the average amount (pounds) applied to 87 agricultural crops and the acres of crops treated for counties...

  9. Grayscale Hawaii Shaded Relief ? 200-Meter Resolution - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The grayscale Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The...

  10. 17 CFR 200.41 - Quorum of the Commission.

    Science.gov (United States)

    2010-04-01

    ...; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Disposition of Commission Business § 200.41 Quorum of the... office; and provided further that on any matter of business as to which the number of members in office...

  11. NSF Obligations for Top 200 Institutions by Fiscal Year

    Data.gov (United States)

    National Science Foundation — An text/xml file containing FY 2001 through FY 2015 National Science Foundation (NSF) obligations by institution for the top 200 recipients defined in terms of total...

  12. Computer Center: Software Review: The DynaPulse 200M.

    Science.gov (United States)

    Pankiewicz, Philip R., Ed.

    1995-01-01

    Reviews the DynaPulse 200M Education Edition microcomputer-based laboratory, which combines interactive software with curriculum and medical instrumentation to teach students about the cardiovascular system. (MKR)

  13. Color Alaska Shaded Relief ? 200-Meter Resolution - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The NED is...

  14. Color Hawaii Shaded Relief ? 200-Meter Resolution - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The NED is...

  15. 34 CFR 200.33 - Identification for corrective action.

    Science.gov (United States)

    2010-07-01

    ... AYP by the end of the second full school year after the LEA has identified the school for improvement under § 200.32(a) or (b), or by the end of the first full school year after the LEA has identified the...; and (2) Not later than the first day of the 2002-2003 school year— (i) In accordance with § 200.44...

  16. 21 CFR 73.200 - Synthetic iron oxide.

    Science.gov (United States)

    2010-04-01

    ... million. Mercury (as Hg) , not more than 1 part per million. (2) Synthetic iron oxide for dog and cat food... food. (2) Synthetic iron oxide may be safely used for the coloring of dog and cat foods in an amount... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Synthetic iron oxide. 73.200 Section 73.200 Food...

  17. Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle.

    Directory of Open Access Journals (Sweden)

    Siddappa N Byrareddy

    Full Text Available Lectin-like molecules and their receptors are cell surface molecules that have been shown to play a role in either facilitating infection or serving as transporters of HIV/SIV in vivo. The role of these lectin-like molecules in the pathogenesis of HIV/SIV infection continues to be defined. In efforts to gain further insight on the potential role of these lectin-like molecules, our laboratory generated monoclonal antibodies (mAb against the human analogs of rhesus macaque CD200, CD200R and Mincle, since the rhesus macaques are accepted as the most reliable animal model to study human HIV infection. The characterization of the cell lineages from the blood and various tissues of rhesus macaques that express these lectin-like molecules are described herein. Among the mononuclear cells, the cells of the myeloid lineage of rhesus macaques are the predominant cell lineages that express readily detectable levels of CD200, CD200R and Mincle that is similar to the expression of Siglec-1 and Siglec-3 reported by our laboratory earlier. Subset analysis revealed that a higher frequency of the CD14+/CD16- subset from normal rhesus macaques express CD200, CD200R and Mincle. Differences in the frequencies and density of expression of these molecules by the gated population of CD14+ cells from various tissues are noted with PBMC and bone marrow expressing the highest and the mononuclear cells isolated from the colon and ileum expressing the lowest levels. While a significant frequency of pDCs and mDCs express Siglec-1/Siglec-3, a much lower frequency expresses CD200, CD200R and Mincle in PBMCs from rhesus macaques. The mAb against CD200 and CD200R but not Mincle appear to inhibit the infection of macrophage tropic SIV/SHIV in vitro. We conclude that these mAbs may have potential to be used as adjunctive therapeutic agents to control/inhibit SIV/HIV infection.

  18. Anti-p200 pemphigoid responding to dapsone

    Directory of Open Access Journals (Sweden)

    Laura Van Lerberghe

    2014-03-01

    Full Text Available Anti-p200 pemphigoid is a rare autoimmune subepidermal blistering disease. Clinical presentation is similar to standard bullous pemphigoid (BP but mucous membranes and cephalic lesions are more frequent. Histology and direct immunofluorescence (IF are identical to BP but indirect IF discloses linear deposits of immunoglobulin G (IgG on the dermal side of artificial salt-split skin. Specific diagnosis is based on western immunoblotting that shows circulating IgG recognizing a 200-kDa protein localized on the dermal extract. The 200-kDa antigen was recently identified as laminin γ1. Anti-p200 pemphigoid should be considered before all atypical or topical steroid-resistant bullous disease, as well as mucous membranes pemphigoid or epidermolysis bullosa acquisita. Dapsone appears to be the most effective treatment and should be used as the first option in combination with topical steroids. In this report, we describe the case of a patient with a typical clinical and immunopathological anti-p200 pemphigoid, responding to a combination of topical steroids and dapsone.

  19. Spall and damage behavior of S200F beryllium

    Energy Technology Data Exchange (ETDEWEB)

    Adams, Chris D [Los Alamos National Laboratory; Anderson, William W [Los Alamos National Laboratory; Gray, George T [Los Alamos National Laboratory; Blumenthal, William R [Los Alamos National Laboratory; Owens, Chuck T [Los Alamos National Laboratory; Freibert, Franz J [Los Alamos National Laboratory; Montoya, Johnny M [Los Alamos National Laboratory; Contreras, Paul J [Los Alamos National Laboratory

    2009-01-01

    We have performed a series of plate impact experiments to study the strength and spall damage behavior of S200F Be. Peak stresses achieved were in the range from 5.6-19.2 GPa. VISAR data show long rise times in the approach to the shocked state believed to be the result of twinning occurring alongside, or in defference to slip, in this hcp material, with its free surface never achieving a steady velocity. This data indicate brittle spall behavior with spall strengths in the range of 0.8-0.9 GPa. In experiments where target thickness is varied, we see evidence of precursor decay and present calculations of the Hugoniot Elastic Limit (HEL). Beryllium is a strategically important material to the aerospace and defense industries worldwide. In spite of this, there is surprisingly little recent literature on the dynamic behavior of this material, particularly the S200F grade. Much of the earlier work was performed on either S200D or S200E grades of Be [1,2] from Brush Wellman, Inc., or on material of unstated pedigree [3]. A discussion of the evolution in material processing, resulting chemical composition, grain size, and crystallographic texture in these as-processed grades of Be can be found in [4]. In general, progressing from S200D, to E, to F entails reduced BeO and other impurity contents, reduced grain size, and a reduction in crystallographic texture of the starting material [4]. The primary goal of this investigation was to study the strength and damage behavior of S200F under dynamic loading conditions. A secondary goal was to obtain equation-of-state (EOS) data to supplement and compare with those already reported in the literature.

  20. Generation and detection of ultrabroadband infrared wave exceeding 200 THz

    Directory of Open Access Journals (Sweden)

    Ashida Masaaki

    2013-03-01

    Full Text Available By focusing a hollow-fiber compressed intense 10–fs pulse and its second harmonic in air, an ultrabroadband infrared pulse with a spectral range of 1–200 THz is generated through a plasma. Coherent detection of the signal up to 100 THz is achieved with electro–optic sampling and THz air-breakdown-coherent-detection. The drastic dependence on the orientation of the second harmonic crystal is clarified in a range of 100–200 THz. From these, the whole frequency components are confirmed to be generated from the AC biased plasma and phase-locked.

  1. 34 CFR 200.2 - State responsibilities for assessment.

    Science.gov (United States)

    2010-07-01

    ... 200.2 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND..., LEA, and school by— (i) Gender; (ii) Each major racial and ethnic group; (iii) English proficiency... additional assessments— (1) May not reduce the number, or change the identity, of schools that would...

  2. 34 CFR 200.28 - Schoolwide program components.

    Science.gov (United States)

    2010-07-01

    ... development activities regarding the use of academic assessments described in § 200.2 to enable them to... EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Improving... student academic achievement; (2)(i) Address the needs of all students in the school, particularly the...

  3. 45 CFR 2541.200 - Standards for financial management systems.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Standards for financial management systems. 2541... STATE AND LOCAL GOVERNMENTS Post-Award Requirements § 2541.200 Standards for financial management... violation of the restrictions and prohibitions of applicable statutes. (b) The financial management systems...

  4. Microbial keratitis in Gujarat, Western India: findings from 200 cases ...

    African Journals Online (AJOL)

    Introduction: The objective of this study was to study the epidemiological characteristics and the microbiological profile of patients suspected with microbial keratitis in Gujarat. Methods: Corneal scraping was collected from 200 consecutive cases of suspected microbial keratitis and was subjected to direct examination and ...

  5. Microbial keratitis in Gujarat, Western India: findings from 200 cases ...

    African Journals Online (AJOL)

    Results: Of the 200 ulcers 55% were culture positive, 26.5% were bacterial ulcers of which 47% were due to Staphylococcus spp. Pure fungal growth was seen in 22% while 6% were mixed ulcers. Fusarium spp. (30%) was the most common fungus followed by Aspergillus spp. (21%). Only one case of Acanthamoeba ...

  6. 24 CFR 200.145 - Property and mortgage assessment.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Property and mortgage assessment... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Mortgage Insurance Procedures and Processing Application for Insurance § 200.145 Property and mortgage assessment. (a) The mortgagor is...

  7. 24 CFR 200.81 - Disbursement of mortgage proceeds.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Disbursement of mortgage proceeds..., Commitment, and Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Mortgage Provisions § 200.81...

  8. 34 CFR 200.38 - Information about action taken.

    Science.gov (United States)

    2010-07-01

    ... Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.38 Information... school for improvement, corrective action, or restructuring. (b) The information referred to in paragraph... actions or restructuring plans. (Approved by the Office of Management and Budget under control number 1810...

  9. 34 CFR 200.13 - Adequate yearly progress in general.

    Science.gov (United States)

    2010-07-01

    ... Improving Basic Programs Operated by Local Educational Agencies Adequate Yearly Progress (ayp) § 200.13 Adequate yearly progress in general. (a) Each State must demonstrate in its State plan what constitutes AYP... continuous and substantial academic improvement for all students; (4) Measures the progress of all public...

  10. Arbitrary waveform modulated pulse EPR at 200 GHz

    Science.gov (United States)

    Kaminker, Ilia; Barnes, Ryan; Han, Songi

    2017-06-01

    We report here on the implementation of arbitrary waveform generation (AWG) capabilities at ∼200 GHz into an Electron Paramagnetic Resonance (EPR) and Dynamic Nuclear Polarization (DNP) instrument platform operating at 7 T. This is achieved with the integration of a 1 GHz, 2 channel, digital to analog converter (DAC) board that enables the generation of coherent arbitrary waveforms at Ku-band frequencies with 1 ns resolution into an existing architecture of a solid state amplifier multiplier chain (AMC). This allows for the generation of arbitrary phase- and amplitude-modulated waveforms at 200 GHz with >150 mW power. We find that the non-linearity of the AMC poses significant difficulties in generating amplitude-modulated pulses at 200 GHz. We demonstrate that in the power-limited regime of ω1 10 MHz) spin manipulation in incoherent (inversion), as well as coherent (echo formation) experiments. Highlights include the improvement by one order of magnitude in inversion bandwidth compared to that of conventional rectangular pulses, as well as a factor of two in improvement in the refocused echo intensity at 200 GHz.

  11. 15 CFR 200.105 - Standard reference data.

    Science.gov (United States)

    2010-01-01

    ..., PROCEDURES, AND FEES § 200.105 Standard reference data. Data on the physical and chemical properties of the large variety of substances used in science and technology need to be compiled and evaluated for... user needs for data. The OSRD's present program is assembled under a series of tasks which include data...

  12. Internal pair decay of giant resonances in hot Pb-200

    NARCIS (Netherlands)

    Schadmand, S; Varma, R; Banerjee, S.R.; Back, BB; Hofman, DJ; Montoya, CP; Paul, P

    1996-01-01

    Electron-positron pairs emitted during the de-excitation of hot Pb-200 from the reaction 95 MeV F-19 + Ta-181 were detected with the Stony Brook pair detector. The internal pair decay from the giant dipole resonance (GDR) built on excited states in a heavy nucleus is cleanly observed for the first

  13. 21 CFR 137.200 - Whole wheat flour.

    Science.gov (United States)

    2010-04-01

    ... flour is not more than 15 percent. It may contain ascorbic acid in a quantity not to exceed 200 parts... ascorbic acid is added, the label shall bear the statement “Ascorbic acid added as a dough conditioner... the availability of this material at NARA, call 202-741-6030, or go to: http://www.archives.gov...

  14. 40 CFR 265.200 - Waste analysis and trial tests.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Waste analysis and trial tests. 265... DISPOSAL FACILITIES Tank Systems § 265.200 Waste analysis and trial tests. In addition to performing the... different process than any previously used in that tank system: (a) Conduct waste analyses and trial...

  15. Phenotype abnormality: 200 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 200 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u706i decreased number... of trichome in organ named flower ... flower ... present in fewer numbers in organism ... trichome ...

  16. 24 CFR 401.200 - Who may be a PAE?

    Science.gov (United States)

    2010-04-01

    ...) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Who may be a PAE? 401.200 Section...

  17. 34 CFR 200.35 - Delay and removal.

    Science.gov (United States)

    2010-07-01

    ... school makes AYP for one year; or (ii) The school's failure to make AYP is due to exceptional or...) of this section in determining the number of consecutive years of the school's failure to make AYP... Programs Operated by Local Educational Agencies Lea and School Improvement § 200.35 Delay and removal. (a...

  18. 34 CFR 200.32 - Identification for school improvement.

    Science.gov (United States)

    2010-07-01

    ... which the LEA administered the assessments that resulted in the school's failure to make AYP for a... in the school's failure to make AYP for a second consecutive year— (1) The school is subject to the... 34 Education 1 2010-07-01 2010-07-01 false Identification for school improvement. 200.32 Section...

  19. Acceptatierapport van 17 SX200 zwarte rook monitoren

    NARCIS (Netherlands)

    Hijink BM; MON; LLO

    2002-01-01

    In this Report the results of an acceptance research for 17 new ETL SX200 Black Smoke monitors is presented. The new monitors are compared with the LML method EEL43. The new monitor is an automated instrument, serving to replace present manual LML monitors. It is more advanced and more stable than

  20. Acceptatierapport van 17 SX200 zwarte rook monitoren

    NARCIS (Netherlands)

    Hijink BM; MON; LLO

    2002-01-01

    De resultaten worden gepresenteerd van een acceptatie onderzoek van 17 nieuwe ETL SX200 Black Smoke monitoren. De nieuwe monitoren zijn vergeleken met de LML methode EEL43. De nieuwe monitor is een geautomatiseerde en stabielere uitvoering van de LML methode. De LML methode had nog veel

  1. The Enriched Xenon Observatory: EXO-200 and Ba+ tagging

    Science.gov (United States)

    Dolinski, M. J.; EXO Collaboration

    2012-08-01

    The Enriched Xenon Observatory (EXO) is a proposed ton-scale double beta decay experiment with a tentative design sensitivity to the Majorana mass of ˜10 meV. The first phase of EXO is EXO-200, which uses 200 kg of Xe enriched to 80% in 136Xe to search for neutrinoless double beta decay. EXO-200 is a liquid Xe time projection chamber with the ability to detect both scintillation and ionization signals. The detector is constructed from ultra-low background materials and is currently installed at the Waste Isolation Pilot Plant, a salt mine with a 1600 meter water equivalent overburden. The projected 2 year sensitivity for EXO-200 is T1/20ν>6.4×1025 y at 90% confidence level. Looking toward a ton-scale EXO, one unique feature of the experiment is the proposal to identify the barium daughter produced by 136Xe double beta decay on an event-by-event basis. This technique will allow for the elimination of all backgrounds other than the background from the two-neutrino double beta decay spectrum. The EXO Collaboration is exploring a number of options to implement Ba-daughter tagging in the next generation EXO experiment.

  2. 17 CFR 200.735-3 - General provisions.

    Science.gov (United States)

    2010-04-01

    ... 4 Detailed provisions regarding negotiations for future employment are set forth in § 200.735-7. (i... section. (9) Have direct or indirect personal, business or financial affairs which conflict or appear to conflict with his or her official duties and responsibilities. (10)(i) Use, or allow the use of, directly...

  3. Fission barrier heights in the A∼ 200 mass region

    Indian Academy of Sciences (India)

    2015-07-19

    Jul 19, 2015 ... Statistical model analysis is carried out for - and -induced fission reactions using a consistent description for fission barrier and level density in A ∼ 200 mass region. A continuous damping of shell correction with excitation energy is considered. Extracted fission barriers agree well with the recent ...

  4. 21 CFR 200.50 - Ophthalmic preparations and dispensers.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Ophthalmic preparations and dispensers. 200.50... preparations and dispensers. (a)(1) Informed medical opinion is in agreement that all preparations offered or... of injury resulting from contamination during use. (c) Eye cups, eye droppers, and other dispensers...

  5. 48 CFR 51.200 - Scope of subpart.

    Science.gov (United States)

    2010-10-01

    ... Section 51.200 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT USE OF GOVERNMENT SOURCES BY CONTRACTORS Contractor Use of Interagency Fleet Management System (IFMS... of interagency fleet management system (IFMS) vehicles and related services. In this subpart, the...

  6. Software Review: The DynaPulse 200M.

    Science.gov (United States)

    Pankiewicz, Philip R., Ed.

    1995-01-01

    Contains an illustration and text to aid in describing the DynaPulse 200M Education Edition microcomputer-based laboratory (MBL), which combines interactive software with curriculum and medical instruction to teach students about the cardiovascular system. Review includes key features of the software, cost, and ease of use. (ZWH)

  7. 17 CFR 200.610 - Self-evaluation.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Self-evaluation. 200.610...-evaluation. (a) The agency shall, by September 6, 1989, evaluate its current policies and practices, and the... handicaps or organizations representing individuals with handicaps, to participate in the self-evaluation...

  8. 21 CFR 584.200 - Ethyl alcohol containing ethyl acetate.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Ethyl alcohol containing ethyl acetate. 584.200... Ethyl alcohol containing ethyl acetate. The feed additive ethyl alcohol containing ethyl acetate meets... having had added the equivalent of 4.25 gallons of 100 percent ethyl acetate. It is used in accordance...

  9. Present Status and Future Perspectives for the EXO-200 Experiment

    Directory of Open Access Journals (Sweden)

    Giorgio Gratta

    2013-01-01

    Full Text Available The EXO collaboration has built and operated a 200 kg liquid xenon detector for studies of double beta decay. This paper summarizes the results obtained so far and their significance. The excellent performance of the detector encourages the concept of a much larger detector to obtain improved sensitivity to the possible detection of the neutrinoless decay mode of xenon.

  10. 34 CFR 200.51 - Notice of SEA action.

    Science.gov (United States)

    2010-07-01

    ... Programs Operated by Local Educational Agencies Lea and School Improvement § 200.51 Notice of SEA action... parents— (A) In an understandable and uniform format, including alternative formats upon request; and (B... information to the parents of each student enrolled in a school served by the LEA— (i) Directly, through such...

  11. 19 CFR 200.735-111 - Gambling, betting, and lotteries.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Gambling, betting, and lotteries. 200.735-111...-111 Gambling, betting, and lotteries. An employee shall not participate, while on Government-owned or... a gambling device, in conducting a lottery or pool, in a game for money or property, or in selling...

  12. Language Arts Lingo: Glossaries and Flashcards for 200+ Terms.

    Science.gov (United States)

    Blount, R. Howard, Jr.

    Intended for teachers of grades 4-8, this book provides tools and resources to help students fall in love with literature. The book contains reproducible glossaries containing over 200 literary, genre, book content, and book construction terms, along with removable flashcards, to make reviewing language arts essentials easy, enjoyable, and fun.…

  13. 42 CFR 403.200 - Basis and scope.

    Science.gov (United States)

    2010-10-01

    ... PROVISIONS SPECIAL PROGRAMS AND PROJECTS Medicare Supplemental Policies § 403.200 Basis and scope. (a) Provisions of the legislation. This subpart implements, in part, section 1882 of the Social Security Act. The intent of that section is to enable Medicare beneficiaries to identify Medicare supplemental policies...

  14. Pulsar polarisation below 200 MHz: Average profiles and propagation effects

    NARCIS (Netherlands)

    Noutsos, A.; Sobey, C.; Kondratiev, V.I.; Weltevrede, P.; Verbiest, J.P.W.; Karastergiou, A.; Kramer, M.; Kuniyoshi, M.; Alexov, A.; Breton, R.P.; Bilous, A.V.; Cooper, S.; Falcke, H.; Grießmeier, J.M.; Hassall, T.E.; Hessels, J.W.T.; Keane, E.F.; Osłowski, S.; Pilia, M.; Serylak, M.; Stappers, B.W.; ter Veen, S.; van Leeuwen, J.; Zagkouris, K.; Anderson, K.; Bähren, L.; Bell, M.; Broderick, J.; Carbone, D.; Cendes, Y.; Coenen, T.; Corbel, S.; Eislöffel, J.; Fender, R.; Garsden, H.; Jonker, P.; Law, C.; Markoff, S.; Masters, J.; Miller-Jones, J.; Molenaar, G.; Osten, R.; Pietka, M.; Rol, E.; Rowlinson, A.; Scheers, B.; Spreeuw, H.; Staley, T.; Stewart, A.; Swinbank, J.; Wijers, R.; Wijnands, R.; Wise, M.; Zarka, P.; van der Horst, A.

    2015-01-01

    Aims. We present the highest-quality polarisation profiles to date of 16 non-recycled pulsars and four millisecond pulsars, observed below 200 MHz with the LOFAR high-band antennas. Based on the observed profiles, we perform an initial investigation of expected observational effects resulting from

  15. Pulsar polarisation below 200 MHz: Average profiles and propagation effects

    NARCIS (Netherlands)

    A. Noutsos; C.A. Sobey; V.I. Kondratiev; P. Weltevrede; J.P.W. Verbiest; A. Karastergiou; M. Kramer; M. Kuniyoshi; A. Alexov; R.P. Breton; A.V. Bilous; S. Cooper; H. Falcke; J.-M. Grießmeier; T.E. Hassall; J.W.T. Hessels; E.F. Keane; S. Oslowski; M. Pilia; M. Serylak; B.W. Stappers; S. ter Veen (Sander); J. van Leeuwen (Joeri); K. Zagkouris; K. Anderson; L. Baehren; M.E. Bell; J.W. Broderick; D. Carbone; Y.N. Cendes; T. Coenen; S. Corbel; J. Eislöffel; R.P. Fender; H. Garsden; P. Jonker; C.J. Law; S. Markoff; J. Masters; J.C.A. Miller-Jones; G.J. Molenaar; R. Osten; M. Pietka; E. Rol; A. Rowlinson; L.H.A. Scheers (Bart); H. Spreeuw; T.D. Staley; A.J. Stewart; J.D. Swinbank; R.A.M.J. Wijers (Ralph); R. Wijnands; M.W. Wise (Michael); P. Zarka; A.J. van der Horst

    2015-01-01

    htmlabstractAims: We present the highest-quality polarisation profiles to date of 16 non-recycled pulsars and four millisecond pulsars, observed below 200 MHz with the LOFAR high-band antennas. Based on the observed profiles, we perform an initial investigation of expected observational effects

  16. Russia to invest 200 million Swiss Francs in international accelerator

    CERN Multimedia

    2001-01-01

    Russia will invest 200 million CHF in the LHC project, according to first deputy industry, science and technologies minister. The results of scientific research in the center will be use in various industries, enabling new Russian technologies to enter the world market.

  17. Governing martial traditions: Post-conflict ritual sites in Iron Age Northern Europe (200 BC–AD 200)

    DEFF Research Database (Denmark)

    Løvschal, Mette; Holst, Mads Kähler

    2018-01-01

    Iron Age martial ritual sites constitute some of the richest archaeological evidence that violence and mass behavior not only became increasingly a part of the political reality in the Iron Age, but that it subsequently began to permeate the religious sphere. Of particular interest are the post...... in the period 200 BC–AD 200. It is based on a new compilation of 80 sites with post-conflict ritual practices from this period. We suggest that the significant latitude in the combination of different martial practices and elements points both to local customs and to supra-regional links. This pattern...

  18. CCNA routing and switching review guide exams 100-101, 200-101, and 200-120

    CERN Document Server

    Lammle, Todd

    2013-01-01

    Todd Lammle's focused, concise review guide, updated for the latest CCNA exams CCNA is one of the most sought after certifications for IT professionals. If you're preparing for the CCNA Routing and Switching certification, this Sybex review guide offers the best quick review available. Organized by exam objective, it's the perfect supplement to other learning tools, including the Sybex CCNA Routing and Switching Study Guide (ISBN: 9781118749616). All exam topics from exams 100-101, 200-101, and 200-120 are thoroughly covered, and additional study materials including bonus exams, electronic f

  19. CCNA routing and switching study guide exams 100-101, 200-101, and 200-120

    CERN Document Server

    Lammle, Todd

    2013-01-01

    Prepare for the new CCNA exams with this Todd Lammle study guide Cisco author, speaker, and trainer Todd Lammle is considered the authority on all things networking, and his books have sold almost a million copies worldwide. This all-purpose CCNA study guide methodically covers all the objectives of the ICND1 (100-101) and ICND2 (200-101) exams as well as providing additional insight for those taking CCNA Composite (200-120) exam. It thoroughly examines operation of IP data networks, LAN switching technologies, IP addressing (IPv4/IPv6), IP routing technologies, IP services, network device s

  20. Pathogenicity of autoantibodies in anti-p200 pemphigoid.

    Directory of Open Access Journals (Sweden)

    Katerina Vafia

    Full Text Available Recently, the C-terminus of laminin γ1 has been identified as target antigen in anti-p200 pemphigoid and the disease was renamed as anti-laminin γ1 pemphigoid. However, the pathogenic relevance of these autoantibodies has not yet been demonstrated. Therefore, we employed an ex vivo model of autoantibody-mediated leukocyte-dependent neutrophil activation and dermal-epidermal separation (DES using cryosections of human skin. We showed that anti-p200 pemphigoid sera (n = 7 induced DES in a time-dependent manner, in contrast to sera from healthy controls. Furthermore, laminin γ1-specific IgG and serum depleted from anti-laminin γ1 reactivity were generated using the recombinant C-terminus of laminin γ1 (LAMC1-term; amino acids 1364 to 1609. Interestingly, both fractions labeled the dermal-epidermal-junction (DEJ by indirect immunofluorescence microscopy on human foreskin and recognized a 200 kDa protein by immunoblotting with dermal extract. Human and rabbit IgG against LAMC1-cterm failed to attract neutrophils at the DEJ and to induce DES. In contrast, patient serum depleted from LAMC1-cterm reactivity led to the same extent of DES as non-depleted IgG. Repeated injection of rabbit anti-murine LAMC1-cterm IgG into both neonatal and adult C57BL/6mice as well as repetitive immunization of various mouse strains with murine LAMC1-cterm failed to induce macro- and microscopic lesions. In all mice, circulating anti-LAMC1-cterm antibodies were present, but only in some mice, IgG deposits were seen at the DEJ. We conclude that autoantibodies in anti-p200 pemphigoid sera are pathogenic while pathogenicity is not mediated by autoantibodies against laminin γ1. Further studies are needed to identify the pathogenically relevant autoantigen in anti-p200 pemphigoid.

  1. Feasibility study report for the 200-BP-1 operable unit

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This feasibility study examines a range of alternatives and provides recommendations for selecting a preferred alternative for remediating contamination at the 200-BP-1 operable unit. The 200-BP-1 operable unit is located in the center of the Hanford Site along the northern boundary of the 200 East Area. The 241-BY Tank Farm is located immediately to the south of the operable unit. 200-BP-1 is a source operable unit with contaminated soils associated primarily with nine inactive cribs (known as the 216-B cribs). These cribs were used for disposal of low-level radioactive liquid waste from U Plant uranium recovery operations, and waste storage tank condensate from the adjacent 241-BY Tank Farm. The cribs used for disposal of U Plant waste were in operation from 1955--1965, and the cribs used for disposal of tank condensate were in operation from 1965--1975. In addition to the cribs, four unplanned releases of radioactive materials have occurred within the operable unit. Contaminated surface soils associated with the unplanned releases have been consolidated over the cribs and covered with clean soil to reduce contaminant migration and exposure. Discharge of wastes to the cribs has resulted in soil and groundwater contamination. The groundwater is being addressed as part of the 200 East Aggregate Area, groundwater operable unit. Contaminated soils at the site can be categorized by the types of contaminants, their distribution in the soil column, and the risk posed by the various potential exposure pathways. Below the clean soil cover, the near surface soils contain low-levels of contamination with cesium-137, radium-226, strontium-90, thorium-228, and uranium. The lifetime incremental cancer risk associated with these soils if they were exposed at the surface is 9{times}10{sup {minus}5}.

  2. 76 FR 12619 - Airworthiness Directives; The Boeing Company 737-200, -200C, -300, -400, and -500 Series Airplanes

    Science.gov (United States)

    2011-03-08

    ... nondestructive test (NDT) methods in accordance with Part 6 of the Boeing 737 Non-Destructive Test NDT Manual. As... to supersede an existing airworthiness directive (AD) that applies to certain Boeing Model 737-200... Boeing Alert Service Bulletin 737-53A1210, Revision 3, dated July 16, 2009) and resulted in re-evaluation...

  3. Investigation of radioactivity-induced backgrounds in EXO-200

    Energy Technology Data Exchange (ETDEWEB)

    Albert, J. B.; Auty, D. J.; Barbeau, P. S.; Beck, D.; Belov, V.; Benitez-Medina, C.; Breidenbach, M.; Brunner, T.; Burenkov, A.; Cao, G. F.; Chambers, C.; Cleveland, B.; Coon, M.; Craycraft, A.; Daniels, T.; Danilov, M.; Daugherty, S. J.; Davis, C. G.; Davis, J.; Delaquis, S.; Der Mesrobian-Kabakian, A.; DeVoe, R.; Didberidze, T.; Dolgolenko, A.; Dolinski, M. J.; Dunford, M.; Fairbank, W.; Farine, J.; Feldmeier, W.; Fierlinger, P.; Fudenberg, D.; Giroux, G.; Gornea, R.; Graham, K.; Gratta, G.; Hall, C.; Herrin, S.; Hughes, M.; Jewell, M. J.; Jiang, X. S.; Johnson, A.; Johnson, T. N.; Johnston, S.; Karelin, A.; Kaufman, L. J.; Killick, R.; Koffas, T.; Kravitz, S.; Kuchenkov, A.; Kumar, K. S.; Leonard, D. S.; Licciardi, C.; Lin, Y. H.; Ling, J.; MacLellan, R.; Marino, M. G.; Mong, B.; Moore, D.; Nelson, R.; Odian, A.; Ostrovskiy, I.; Piepke, A.; Pocar, A.; Prescott, C. Y.; Rivas, A.; Rowson, P. C.; Russell, J. J.; Schubert, A.; Sinclair, D.; Smith, E.; Stekhanov, V.; Tarka, M.; Tolba, T.; Tsang, R.; Twelker, K.; Vuilleumier, J. -L.; Waite, A.; Walton, J.; Walton, T.; Weber, M.; Wen, L. J.; Wichoski, U.; Wood, J.; Yang, L.; Yen, Y. -R.; Zeldovich, O. Ya.

    2015-07-15

    The search for neutrinoless double-beta decay ( 0 ν β β ) requires extremely low background and a good understanding of their sources and their influence on the rate in the region of parameter space relevant to the 0 ν β β signal. We report on studies of various β and γ backgrounds in the liquid-xenon-based EXO- 200 0 ν β β experiment. With this work we try to better understand the location and strength of specific background sources and compare the conclusions to radioassay results taken before and during detector construction. Finally, we discuss the implications of these studies for EXO-200 as well as for the next-generation, tonne-scale nEXO detector.

  4. Fact Sheet for KM200 Front-end Electronics

    Energy Technology Data Exchange (ETDEWEB)

    Ianakiev, Kiril Dimitrov [Los Alamos National Laboratory; Iliev, Metodi [Los Alamos National Laboratory; Swinhoe, Martyn Thomas [Los Alamos National Laboratory

    2015-07-08

    The KM200 device is a versatile, configurable front-end electronics boards that can be used as a functional replacement for Canberra’s JAB-01 boards based on the Amptek A-111 hybrid chip, which continues to be the preferred choice of electronics for large number of the boards in junction boxes of multiplicity counters that process the signal from an array of 3He detectors. Unlike the A-111 chip’s fixed time constants and sensitivity range, the shaping time and sensitivity of the new KM200 can be optimized for demanding applications such as spent fuel, and thus could improve the safeguards measurements of existing systems where the A-111 or PDT electronics does not perform well.

  5. Diodes Schottky diamant fonctionnant à 200°C

    OpenAIRE

    Monflier, Richard; Isoird, Karine; Cazarré, Alain; Tasselli, Josiane; Servel, Alexandra; ACHARD, Jocelyn; Eon, David

    2015-01-01

    Les caractéristiques courant-tension jusqu'à 200°C de diodes Schottky diamant verticales et pseudo-verticales réalisées dans le cadre du projet DIAMONIX2 sont présentées dans cet article. Sur les différents échantillons testés le taux de fonctionnalité est supérieur à 75%. Pour les diodes verticales la densité de courant atteint 488 A/cm 2 à 200°C, et un courant de fuite < 10-7 A/cm 2 à 50 V. Toutefois, la hauteur de barrière de 1,96 eV et le coefficient d'idéalité de 1,77 sont certainement c...

  6. Diodes Schottky diamant fonctionnant à 200°C

    OpenAIRE

    Monflier, Richard; Isoird, Karine; Cazarre, Alain; Tasselli, Josiane; Servel, Alexandra; ACHARD, Jocelyn; Eon, David; Valdivia Birnbaum, Maria José

    2016-01-01

    International audience; Les caractéristiques courant-tension jusqu'à 200 °C de diodes Schottky diamant verticales et pseudo-verticales réalisées dans le cadre du projet DIAMONIX2 sont présentées dans cet article. Sur les différents échantillons testés le taux de fonctionnalité est supérieur à 75 % et atteint même 100 % pour l'un d'entre eux. Pour les diodes verticales la densité de courant atteint 488 A/cm2 à 200 °C et pour les diodes pseudo-verticales une densité de courant supérieure à 1000...

  7. Small passenger car transmission test-Chevrolet 200 transmission

    Science.gov (United States)

    Bujold, M. P.

    1980-01-01

    The small passenger car transmission was tested to supply electric vehicle manufacturers with technical information regarding the performance of commerically available transmissions which would enable them to design a more energy efficient vehicle. With this information the manufacturers could estimate vehicle driving range as well as speed and torque requirements for specific road load performance characteristics. A 1979 Chevrolet Model 200 automatic transmission was tested per a passenger car automatic transmission test code (SAE J651b) which required drive performance, coast performance, and no load test conditions. The transmission attained maximum efficiencies in the mid-eighty percent range for both drive performance tests and coast performance tests. Torque, speed and efficiency curves map the complete performance characteristics for Chevrolet Model 200 transmission.

  8. Stabilization of 200-atom platinum nanoparticles by organosilane fragments

    KAUST Repository

    Pelzer, Katrin

    2011-04-19

    Three\\'s a charm: Platinum nanoparticles of 2 nm diameter and containing approximately 200 atoms covered with n-octylsilyl groups (see picture, right; Pt blue, Si red, C gray, H turquoise) form when [Pt(dba)2] (dba=dibenzylideneacetone) decomposes in the presence of n-octylsilane. The particles adopt a cuboctahedral structure with an edge length of three atoms. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Phenotype-gene: 200 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 200 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1198i decreased size for quantity.../metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u12566580i decreased size for quantity of inflorescence http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u721i AT4G34460

  10. 76 FR 29673 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes, and Model A340-200 and...

    Science.gov (United States)

    2011-05-23

    ... Directives; Airbus Model A330-200 and -300 Series Airplanes, and Model A340-200 and -300 Series Airplanes..., Aerospace Engineer, International Branch, ANM-116, Transport Airplane Directorate, FAA, 1601 Lind Avenue, SW... Service Bulletins A330-92-3077, Revision 01, dated March 29, 2010 (for Model A330-200 and -300 series...

  11. The JHP 200-MeV proton linear accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Takao [National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan)

    1997-11-01

    A 200-MeV proton linear accelerator for the Japanese Hadron Project (JHP) has been designed. It consists of a 3-MeV radio-frequency quadrupole linac (RFQ), a 50-MeV drift tube linac (DTL) and a 200-MeV separated-type drift tube linac (SDTL). A frequency of 324 MHz has been chosen for all of the rf structures. A peak current of 30 mA (H{sup -} ions) of 400 {mu}sec pulse duration will be accelerated at a repetition rate of 25 Hz. A future upgrade plan up to 400 MeV is also presented, in which annular-coupled structures (ACS) of 972 MHz are used in an energy range of above 150 or 200 MeV. One of the design features is its high performance for a beam-loss problem during acceleration. It can be achieved by separating the transition point in the transverse motion from that of the longitudinal motion. The transverse transition at a rather low-energy range decreases the effects of space-charge, while the longitudinal transition at a rather high-energy range decreases the effects of nonlinear problems related to acceleration in the ACS. Coupled envelope equations and equipartitioning theory are used for the focusing design. The adoption of the SDTL structure improves both the effective shunt impedance and difficulties in fabricating drift tubes with focusing magnets. An accurate beam-simulation code on a parallel supercomputer was used for confirming any beam-loss problem during acceleration. (author)

  12. Enhanced R200 with Frisch-Grid CZT

    Energy Technology Data Exchange (ETDEWEB)

    Bolotnikov, A. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-12-01

    The goal of this project is to demonstrate an engineering prototype of a gamma ray spectrometer that uses Cadmium Zinc Telluride (CZT) in a configuration comprised of an array of position-sensitive virtual Frisch grid (PSVFG) detectors and show its capability to perform functions that would be useful to the IAEA. The detectors should achieve energy resolution of ~2% at 200 keV and <1% at > 662 keV, thereby outperforming all hand-held instruments currently in use other than cryogenically cooled germanium. BNL will make every effort to transfer the technology to an industrial partner so that robust, fieldable instruments can be manufactured.

  13. Status of the BNL 200 MeV Linac

    Energy Technology Data Exchange (ETDEWEB)

    McNerney, A.; Brennan, J.M.; Briscoe, B.; Brodowski, J.; Horton, R.; LoDestro, V.; Montemurro, P.; Zhang, S.Y.

    1986-01-01

    The BNL 200 MeV Linac normally accelerates H/sup -/ ions during its operating schedule. During selected periods, typically of six to ten weeks duration, polarized H/sup -/ ions are accelerated. Since linac H/sup -/ commissioning, longer 7835 tube lives have been recorded and after initial operating bugs were eliminated, preinjector reliability has improved. Hardware components in the Preinjector, rf system, and ion source have been replaced or upgraded, and plans are being implemented for future system improvements. BLIP operations were initially curtailed during polarized beam running and a pulsed magnet has been installed in LEBT to restore BLIP running time to original levels.

  14. Tartu Old Anatomical Theatre 200-Contribution of German anatomists.

    Science.gov (United States)

    Aunapuu, Marina; Puusepp, Margus; Toomsalu, Maie; Arend, Andres

    2005-09-01

    One of the first centres of medical higher education in the Baltic countries was the University of Tartu (Dorpat), which was founded in 1632 by the Swedish King Gustavus Adolphus II. The University's first genuinely own building, however, the Old Anatomical Theatre, was completed only in 1805 after the re-opening of the University (1802). This year marks the 200th anniversary of its opening. The Old Anatomical Theatre has played an important role in Estonian medicine, and also a number of German morphologists, who have left a deep mark in world science, have worked in this building at different times.

  15. State waste discharge permit application, 200-E chemical drain field

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    As part of the Hanford Federal Facility Agreement and Consent Order negotiations (Ecology et al. 1994), the US Department of Energy, Richland Operations Office, the US Environmental Protection Agency, and the Washington State Department of Ecology agreed that liquid effluent discharges to the ground on the Hanford Site which affect groundwater or have the potential to affect ground would be subject to permitting under the structure of Chapter 173-216 (or 173-218 where applicable) of the Washington Administrative Code, the State Waste Discharge Permit Program. As a result of this decision, the Washington State Department of Ecology and the US Department of Energy, Richland Operations Office entered into Consent Order No. DE 91NM-177, (Ecology and DOE-RL 1991). The Consent Order No. DE 91NM-177 requires a series of permitting activities for liquid effluent discharges. This document presents the State Waste Discharge Permit (SWDP) application for the 200-E Chemical Drain Field. Waste water from the 272-E Building enters the process sewer line directly through a floor drain, while waste water from the 2703-E Building is collected in two floor drains, (north and south) that act as sumps and are discharged periodically. The 272-E and 2703-E Buildings constitute the only discharges to the process sewer line and the 200-E Chemical Drain Field.

  16. Optical coating uniformity of 200mm (8") diameter precut wafers

    Science.gov (United States)

    Burt, Travis C.; Fisher, Mark; Brown, Dean; Troiani, David

    2017-02-01

    Automated spectroscopic profiling (mapping) of a 200 mm diameter near infrared high reflector (centered at 1064 nm) are presented. Spatial resolution at 5 mm or less was achieved using a 5 mm × 1.5 mm monochromatic beam. Reflection changes of 1.0% across the wafer diameter were observed under s-polarized and p- polarized conditions. Redundancy was established for each chord by re-measuring the center of the wafer and reproducibility of approximately used to measure the reflectance and transmittance of a sample across a range of angles (θi) at near normal angles of incidence (AOI). A recent development by Agilent Technologies, the Cary 7000 Universal Measurement Spectrophotometer (UMS) combines both reflection and transmission measurements from the same patch of a sample's surface in a single automated platform for angles of incidence in the range 5°use of MPS on the Cary 7000 UMS with rotational (Φ) and vertical (z) sample positioning control. MPS(θi,Φ,z) provides for automated unattended multi-angle R/T analysis of at 200 mm diameter samples with the goal to provide better spectroscopic measurement feedback into large wafer manufacturing to ensure yields are maximized, product quality is better controlled and waste is reduced before further down-stream processing.

  17. Epidemiology in Ethiopia 200 years after John Snow's birth.

    Science.gov (United States)

    Enquselassie, Fikre

    2013-10-01

    The year 2013 marks exactly 200 years since John Snow, known as the father of modern epidemiology, was born. In 19th century, epidemiologists like John Snow, concentrated almost entirely upon infectious diseases of humans measuring the burden of disease, describing pattern and attempting to understand the transmission dynamics. During the second half of the 20th century; big changes occurred so that epidemiologists in the developed world started to use systematized approaches to investigate the etiologies, conditions and to evaluate interventions through different study designs. However, the situation in the developing world is not the same as the rest of the world. Even 200 years after Snow's birth, epidemiological capacity is lowest in Africa. This article attempts to describe that Ethiopia is not exceptional. In the past few decades, there have been some attempts to build capacity in the country by launching training programs in clinical epidemiology, general epidemiology and field epidemiology. However, not only few epidemiologists are trained, but, limited funding, high-teaching burdens, poor working conditions and low salaries are among important contributors for epidemiological brain drain in Ethiopia. Thus, strengthening learning opportunities and rewarding career paths are required to increase human resource capacity and retain skilled personnel in the field of epidemiology.

  18. Safety analysis, 200 Area, Savannah River Plant: Separations area operations

    Energy Technology Data Exchange (ETDEWEB)

    Perkins, W.C.; Lee, R.; Allen, P.M.; Gouge, A.P.

    1991-07-01

    The nev HB-Line, located on the fifth and sixth levels of Building 221-H, is designed to replace the aging existing HB-Line production facility. The nev HB-Line consists of three separate facilities: the Scrap Recovery Facility, the Neptunium Oxide Facility, and the Plutonium Oxide Facility. There are three separate safety analyses for the nev HB-Line, one for each of the three facilities. These are issued as supplements to the 200-Area Safety Analysis (DPSTSA-200-10). These supplements are numbered as Sup 2A, Scrap Recovery Facility, Sup 2B, Neptunium Oxide Facility, Sup 2C, Plutonium Oxide Facility. The subject of this safety analysis, the, Plutonium Oxide Facility, will convert nitrate solutions of {sup 238}Pu to plutonium oxide (PuO{sub 2}) powder. All these new facilities incorporate improvements in: (1) engineered barriers to contain contamination, (2) barriers to minimize personnel exposure to airborne contamination, (3) shielding and remote operations to decrease radiation exposure, and (4) equipment and ventilation design to provide flexibility and improved process performance.

  19. Over-Expression of CD200 Protects Mice from Dextran Sodium Sulfate Induced Colitis

    Science.gov (United States)

    Chen, Zhiqi; Yu, Kai; Zhu, Fang; Gorczynski, Reginald

    2016-01-01

    Background and aim CD200:CD200 receptor (CD200R) interactions lead to potent immunosuppression and inhibition of autoimmune inflammation. We investigated the effect of "knockout"of CD200 or CD200R, or over-expression of CD200, on susceptibility to dextran sodium sulfate (DSS)—induced colitis, a mouse model of inflammatory bowel disease (IBD). Methods Acute or chronic colitis was induced by administration of dextran sodium sulfate (DSS) in four groups of age-matched C57BL/6 female mice: (1) CD200-transgenic mice (CD200tg); (2) wild-type (WT) mice; (3) CD200 receptor 1-deficient (CD200R1KO) mice; and (4) CD200-deficient (CD200KO) mice. The extent of colitis was determined using a histological scoring system. Colon tissues were collected for quantitative RT-PCR and Immunohistochemical staining. Supernatants from colonic explant cultures and mononuclear cells isolated from colonic tissue were used for ELISA. Results CD200KO and CD200R1KO mice showed greater sensitivity to acute colitis than WT mice, with accelerated loss of body weight, significantly higher histological scores, more severe infiltration of macrophages, neutrophils and CD3+ cells, and greater expression of macrophage-derived inflammatory cytokines, whose production was inhibited in vitro (in WT/CD200KO mouse cells) by CD200. In contrast, CD200tg mice showed less sensitivity to DSS compared with WT mice, with attenuation of all of the features seen in other groups. In a chronic colitis model, greater infiltration of Foxp3+ regulatory T (Treg) cells was seen in the colon of CD200tg mice compared to WT mice, and anti-CD25 mAb given to these mice attenuated protection. Conclusions The CD200:CD200R axis plays an immunoregulatory role in control of DSS induced colitis in mice. PMID:26841120

  20. Characterization of W CMP processes for 200-mm applications

    Science.gov (United States)

    Hansen, David A.; Luo, J. S.; Nguyen, John; Fawley, Gregory; Davis, Sue B.; Marty, Lucky F.; Yang, Fermion

    1996-09-01

    This paper presents Design Of Experiment (DOE) experimental methodology used to determine W CMP process windows for 200 mm wafers using a multi-head polish system, Cybeq Systems IP 8000 polisher. A colloidal dispersed alumina nonferric nitrate slurry and concentric grooved polyurethane pad with a closed cell foam base layer, both from Rodel, were used to examine response matrices for W CMP. Removal rates, non- uniformity and metal: oxide selectivity as a function of polish head pressure and linear velocity were examined. Removal rate trends of W and PECVD oxide, non-uniformity and selectivity as a function of head pressure indicate removal rates > 2000 angstroms/minute, non-uniformity's 10 are achievable. The optimized process obtained through DOE methodology was applied to a device wafer. The corresponding results were a non-uniformity < 2.5%, with no observable dishing, and no observable oxide erosion.

  1. Fall 1998 200 East area biological vector contamination report

    Energy Technology Data Exchange (ETDEWEB)

    CONNELL, D.J.

    1999-03-17

    The purpose of this report is to document the investigation into the cause of the spread of radioactive contamination in September and October 1998 at the Hanford Site's 200 East Area and its subsequent spread to the City of Richland Landfill; identify the source of the contamination; and present corrective actions. The focus and thrust of managing the incident was based on the need to accomplish the following, listed in order of importance: (1) protect the health and safety of the Site workers and the public; (2) contain and control the spread of contamination; (3) identify the source of contamination and the pathways for its spread; and (4) identify the causal factors enabling the contamination.

  2. Photodissociation of NH3 at 106-200 nm

    Science.gov (United States)

    Suto, M.; Lee, L. C.

    1983-01-01

    The absorption and fluorescence cross sections for NH3 are measured in the 106-200 nm region using synchrotron radiation as the light source. The threshold wavelengths for the production of the NH (b to X) and NH (c to a) emissions from NH3 dissociation are measured and compared with previous measurements. The heat of formation of NH determined from these thresholds agrees well with the value determined from thermochemical data. The process of dissociation of NH3 into NH2(2AL) and H2(S) has a significant quantum yield whose maximum at 134 nm is about twice the NH(c) production yield. All the vibronic levels of the B and C states produce the NH2(2A1) emission, contrary to previous theoretical interpretations.

  3. A 200 GHz tripler using a single barrier varactor

    Science.gov (United States)

    Choudhury, Debabani; Frerking, Margaret A.; Batelaan, Paul D.

    1993-01-01

    The GaAs Schottky varactor diode is the nonlinear device most commonly used for submillimeter wave harmonic generation. Output power adequate to serve as a local oscillator source for SIS tunnel junctions has been demonstrated with whisker-contacted GaAs Schottky varactor multipliers in waveguide mounts up to about 800 GHz. In this paper, we present results for a tripler to 200 GHz using a new multiplier device, the single barrier varactor (SBV). This new varactor has potential advantages such as stronger nonlinearities or special symmetry, which make it attractive for submillimeter wave frequency multiplication. The performance of a tripler using a SBV over a output frequency range from 186 to 207 GHz has been measured in a crossed waveguide mount. The theoretical performance of the device has been calculated using large signal analysis. A comparison of theoretical and measured results and a discussion of various losses in the mount and the varactor have also been presented.

  4. A 200 GHz tripler using single barrier varactor

    Science.gov (United States)

    Choudhury, Debabani; Frerking, Margaret A.; Batelaan, Paul D.

    1992-01-01

    The GaAs Schottky varactor diode is the nonlinear device most commonly used for submillimeter wave harmonic generation. Output power adequate to serve as a local oscillator source for SIS tunnel junctions has been demonstrated with whisker-contacted GaAs Schottky varactor multipliers in waveguide mounts up to about 800 GHz. In this paper, we present results for a tripler to 200 GHz using a new multiplier device, the single barrier varactor (SBV). This new varactor has a potential advantages such as stronger nonlinearities or special symmetry, which make it attractive for submillimeter wave frequency multiplication. The performance of a tripler using a SBV over a output frequency range from 186 to 207 GHz has been measured in a crossed waveguide mount. The theoretical performance of the device has been calculated using large signal analysis. A comparison of theoretical and measured results and a discussion of various losses in the mount and the varactor have also been presented.

  5. Results of screening over 200 pristine lithium-ion cells

    DEFF Research Database (Denmark)

    Varela Barreras, Jorge; Raj, Trishna; Howey, David

    2017-01-01

    This paper presents and analyses results from simplified screening tests conducted on more than 200 large format Kokam NMC lithium-ion pouch cells at their beginning of life. Such data are not common in the literature. The cells were sandwiched between two large heat sinks for testing, which...... resistance. In this paper, statistical results show that the cells under test present small cell-to-cell differences in capacities and internal resistances at their beginning-of-life. For example, the relative standard deviation is below 0.4 % for the capacities and 2.5 % for the pure ohmic plus polarization...... resistances. However, these differences may be enhanced by system level issues, and exacerbated over time by complex degradation mechanisms....

  6. Performance Evaluation of the Optical AND Gate at 200 Gbps

    Science.gov (United States)

    Tripathi, Devendra Kr.

    2017-06-01

    The article explores performance investigation for the all optical AND logic gate at the 200 Gbps data rate. Numerical simulations have been executed and output pattern for the AND logic operation has been verified. Accordingly good extinction ratio of 15.8 dB has been observed. Investigations depict optimum optical performance metric with the key deign parameters as the pump power (>1e-4 W), pump current (>1 ‎Å), current injection efficiency (>0.5), modulator bias voltage (>1.25 V), modulator on off ratio (>10 dB) and the SOA reflectivity (>0 dB). The schematic is evident, simpler tender's option to endow different input combinations simultaneously. Furthermore, the outcomes are well sustainable to formulate forthcoming advanced higher data rate all-optical digital processing.

  7. Hypnosis for cancer care: over 200 years young.

    Science.gov (United States)

    Montgomery, Guy H; Schnur, Julie B; Kravits, Kate

    2013-01-01

    Answer questions and earn CME/CNE Hypnosis has been used to provide psychological and physical comfort to individuals diagnosed with cancer for nearly 200 years. The goals of this review are: 1) to describe hypnosis and its components and to dispel misconceptions; 2) to provide an overview of hypnosis as a cancer prevention and control technique (covering its use in weight management, smoking cessation, as an adjunct to diagnostic and treatment procedures, survivorship, and metastatic disease); and 3) to discuss future research directions. Overall, the literature supports the benefits of hypnosis for improving quality of life during the course of cancer and its treatment. However, a great deal more work needs to be done to explore the use of hypnosis in survivorship, to understand the mediators and moderators of hypnosis interventions, and to develop effective dissemination strategies. Copyright © 2012 American Cancer Society, Inc.

  8. 200 more puzzling physics problems with hints and solutions

    CERN Document Server

    Gnädig, Péter; Vigh, Máté

    2016-01-01

    Like its predecessor, 200 Puzzling Physics Problems, this book is aimed at strengthening students' grasp of the laws of physics by applying them to situations that are practical, and to problems that yield more easily to intuitive insight than to brute-force methods and complex mathematics. The problems are chosen almost exclusively from classical, non-quantum physics, but are no easier for that. They are intriguingly posed in accessible non-technical language, and require readers to select an appropriate analysis framework and decide which branches of physics are involved. The general level of sophistication needed is that of the exceptional school student, the good undergraduate, or the competent graduate student; some physics professors may find some of the more difficult questions challenging. By contrast, the mathematical demands are relatively minimal, and seldom go beyond elementary calculus. This further book of physics problems is not only instructive and challenging, but also enjoyable.

  9. First 0νββ results from EXO-200

    Energy Technology Data Exchange (ETDEWEB)

    Farine, J. [Department of Physics, Laurentian Universty, 935 Ramsey Lake Road, Sudbury Ontario, P3E 2C6 Canada (Canada)

    2013-02-15

    We report on a search for neutrinoless double-beta decay of {sup 136}Xe with EXO-200. No signal is observed for a {sup 136}Xe exposure of 26.3 kg-yr, with a background of ∼1.5×10{sup −3}kg({sup enr}LXe){sup −1}yr{sup −1}keV{sup −1} in the ±1σ region of interest. This sets a lower limit on the half-life of the neutrinoless double-beta decay T{sub 1/2}{sup 0νββ}({sup 136}Xe)>1.6×10{sup 25}yr (90% CL), corresponding to effective Majorana masses of less than 140–380 meV, depending on the matrix element calculation.

  10. Multiplexing 200 spatial modes with a single hologram

    Science.gov (United States)

    Rosales-Guzmán, Carmelo; Bhebhe, Nkosiphile; Mahonisi, Nyiku; Forbes, Andrew

    2017-11-01

    The on-demand tailoring of light's spatial shape is of great relevance in a wide variety of research areas. Computer-controlled devices, such as spatial light modulators (SLMs) or digital micromirror devices, offer a very accurate, flexible and fast holographic means to this end. Remarkably, digital holography affords the simultaneous generation of multiple beams (multiplexing), a tool with numerous applications in many fields. Here, we provide a self-contained tutorial on light beam multiplexing. Through the use of several examples, the readers will be guided step by step in the process of light beam shaping and multiplexing. Additionally, we provide a quantitative analysis on the multiplexing capabilities of SLMs to assess the maximum number of beams that can be multiplexed on a single SLM, showing approximately 200 modes on a single hologram.

  11. Results of 200 KW fuel cell evaluation programs

    Energy Technology Data Exchange (ETDEWEB)

    Torrey, J.M.; Merten, G.P. [SAIC, San Diego, CA (United States); Binder, M.J. [Army Construction Engineering Research Labs., Champaign, IL (United States)] [and others

    1996-12-31

    Science Applications International Corporation (SAIC) has installed six monitoring systems on ONSI Corporation 200 kW phosphoric acid fuel cells. Three of the systems were installed for the U.S. Army Construction Engineering Research Laboratories (USACERL) which is coordinating the Department of Defense (DoD) fuel cell Demonstration Program and three were installed under a contract with the New York State Energy Research and Development Authority (NYSERDA). Monitoring of the three NYSERDA sites has been completed. Monitoring systems for the DoD fuel cells were installed in August, 1996 and thus no operating data was available at the time of this writing, but will be presented at the Fuel Cell Seminar. This paper will present the monitoring configuration and research approach for each program. Additionally, summary performance data is presented for the completed NYSERDA program.

  12. Optimization of 200 kV electrostatic accelerator

    Directory of Open Access Journals (Sweden)

    M Nazmabadi

    2015-09-01

    Full Text Available Optimizations on 200 kV electrostatic accelerator have been done in order to increasing ion current on target, improving vacuum condition and reduction in x-rays emission, increasing stability of high voltage power supply and reaching much greater achievable voltage value. The accelerator tube has most important effect on beam tracing in the electrostatic accelerators. So precautions most be considered in designing and constructing of this part. In order to finding permissible tolerances in construction and assembling of 200 kV electrostatic accelerator column, first the effects of angle deviation of a part from accelerator axis on beam track in the accelerator tube was simulated with Simion 7.0 computer program. We found that in order to prevent beam lost, the tolerances of balancing and co-centering of each part should be smaller than 0.1 mm. Each part of accelerator tube constructed by tolerances lower than 0.05 mm. Ultrasonic cleaning method used in pre-assembling process of parts. Because of its excellences, in the new tube we used borosilicate glass instead of high density alumina as insulators between the metallic electrodes. After three days of working vacuum pumps the system reached to 8.0×10-7 and after months to 5.0×10-7 ultimate pressure values. Measurements showed that by these considerations the maximum of reachable ion current on target was 1.1 mA which increased 50% compared to old machine, while x-ray emission intensity was increased by 25%. Optimizations of high voltage power supply are now under studies and tests

  13. Outcome of 200 Pediatric Living Donor Liver Transplantations in India.

    Science.gov (United States)

    Mohan, Neelam; Karkra, Sakshi; Rastogi, Amit; Dhaliwal, Maninder S; Raghunathan, Veena; Goyal, Deepak; Goja, Sanjay; Bhangui, Prashant; Vohra, Vijay; Piplani, Tarun; Sharma, Vivek; Gautam, Dheeraj; Baijal, S S; Soin, A S

    2017-11-15

    To describe our experience of pediatric living donor liver transplantation from India over a period of 12 years. A retrospective analysis of 200 living donor liver transplantation in children (18 years or younger) was done for demographic features, indications, donor and graft profile and outcome. Between September 2004 and July 2016, 200 liver transplants were performed on 197 children. Fifty transplants were done in initial 6 years and 150 in next 6 years. All donors (51% mothers) were discharged with a mean stay of 7 days. The leading indications of liver transplants were cholestatic liver disease (46%) followed by metabolic liver disease (33%) and acute liver failure/acute on chronic liver failure (28.5%). Biliary leakage (8.5%), biliary stricture (9%), hepatic artery thrombosis (4.5%) and portal vein thrombosis (4%) were the most common surgical complications; all could be managed by surgical or interventional radiological measures, except in one child who died. Sepsis, acute rejection and CMV hepatitis in first 6 months were seen in 14.5%, 25% and 17% cases, respectively. Post-transplant lymphoproliferative disease was seen in only 1.5%. Re-transplant rate was 1.5%. The overall 1 year survival rate was 94% and 5 year actuarial survival was 87% with no statistically significant difference between children weight 10 kg. Outcome in acute liver failure did not differ significantly between those with acute on chronic liver failure vs. those with chronic liver disease. Advances in medical and surgical techniques associated with multidisciplinary teams including skilled pediatric liver transplant surgeons, anesthetists, dedicated pediatric hepatologists, pediatric intensivists, interventional radiologists and pathologists resulted in an excellent outcome of living related liver transplants in children. Low age and weight of the baby does not seem to be a contraindication for liver transplantation as outcome were comparable in our experience.

  14. Laparoscopic repair of hiatal hernias: Experience after 200 consecutive cases

    Directory of Open Access Journals (Sweden)

    Bjelović Miloš

    2014-01-01

    Full Text Available Introduction. Repair of hiatal hernias has been performed traditionally via open laparotomy or thoracotomy. Since first laparoscopic hiatal hernia repair in 1992, this method had a growing popularity and today it is the standard approach in experienced centers specialized for minimally invasive surgery. Objective. In the current study we present our experience after 200 consecutive laparoscopic hiatal hernia repairs. Methods. A retrospective cohort study included 200 patients who underwent elective laparoscopic hiatal hernia repair at the Department for Minimally Invasive Upper Digestive Surgery, Clinic for Digestive Surgery, Clinical Center of Serbia in Belgrade from April 2004 to December 2013. Results. Hiatal hernia types included 108 (54% patients with type I, 30 (15% with type III, 62 (31% with giant paraesophageal hernia, while 27 (13.5% patients presented with a chronic gastric volvulus. There were a total of 154 (77% Nissen fundoplications. In 26 (13% cases Nissen procedure was combined with esophageal lengthening procedure (Collis-Nissen, and in 17 (8.5% Toupet fundoplications was performed. Primary retroesophageal crural repair was performed in 164 (82% cases, Cleveland Clinic Foundation suture modification in 27 (13.5%, 4 (2% patients underwent synthetic mesh hiatoplasty, 1 (0.5% primary repair reinforced with pledgets, and 4 (2% autologous fascia lata graft reinforcement. Poor result with anatomic and symptomatic recurrence (indication for revisional surgery was detected in 5 patients (2.7%. Conclusion. Based on the result analysis, we found that laparoscopic hiatal hernia repair was a technically challenging but feasible technique, associated with good to excellent postoperative outcomes comparable to the best open surgery series.

  15. Computerized tomographic studies in cerebral palsy. Analysis of 200 cases

    Energy Technology Data Exchange (ETDEWEB)

    Sugie, Y. (Tokyo Women' s Medical Coll. (Japan))

    1981-09-01

    Computed tomographic (CT) findings in 200 children with cerebral palsy (CP) were analysed from the viewpoint of clinical manifestations, disease complications and etiological factors. CT scans of 135 cases (67.5%) were found to be abnormal and there were 14 (7%) borderline cases. The major abnormality found on CT scans was cerebral atrophy. Other important changes included focal or diffuse low density area in the brain tissue, congenital malformation, and cerebellar atrophy. From the clinical point of view, a large number of patients with spastic tetraplegia and spastic diplegia showed highly abnormal CT scans. On the other hand, in patients with spastic monoplegia, spastic paraplegia, and athetotic type, CT findings were normal or revealed only minor cerebral atrophy. Most children showing asymmetric clinical symptoms had corresponding asymmetric CT abnormalities which included ventricular enlargement, low density area in the brain tissue, and hemispherical volume. There was a significant correlation between the severity of physical impairment and the extent of CT abnormalities. Severely affected children had grossly abnormal CT scans such as hydranencephaly, polycystic change, and extensive cerebral atrophy. In the patients complicated with epilepsy, the incidence and severity of abnormal CT were higher than those of non-epileptic patients. Mentally retarded patients had variable enlargement of the subarachnoidal space depending on the severity of their mental retardation. Patients with suspected postnatal etiology also had high incidence of severe CT abnormality. CT scan is a valuable tool for evaluating patients with CP and in some cases, possible etiology of the disease may be discovered.

  16. Industry, environment and health through 200 years in Manchester

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, Ian; Hodgson, Rob; Lawson, Nigel [School of Geography, University of Manchester, Mansfield Cooper Building, M13 9PL Manchester (United Kingdom)

    2002-05-01

    The Manchester urban area evolved rapidly in the early 19th century from a series of small towns to a major industrial conurbation with huge material flows and worldwide trade connections. A combination of the availability of nearby coalfields, canals, and free trade, which encouraged entrepreneurial enterprise, made Manchester into the 'shock' city of the industrial revolution. Rapid nucleated urban growth associated with industrialisation throughout the 19th century involved an exponential growth in materials transfers and in waste flows. The 20th century suburban dispersal of residential and industrial growth led to further increase in the impact of the urban metabolism, especially in terms of mass: distance of materials movement. The current post-industrial phase in Greater Manchester has to cope with the environmental and social legacies of its industrial past and with growing per capita materials consumption and increases in number of households despite a nearly static population of around 2.5 million. Changes in material flows, land usage and river morphology in Greater Manchester over the past 200 years have reflected changing technologies, industry, economics, social expectations and environmental legislation. Manchester had the first passenger railway, the first inter-basin domestic water transfer in the UK, the first urban smokeless zones and was part of a pioneering land reclamation partnership in the 1970s. Even so, the environmental legacy of industrial material flows constantly presents new challenges, from the cost of reclaiming contaminated brownfield sites to finding destinations for today's urban waste.

  17. [Acute appendicitis. A clinicopathological analysis of 200 cases].

    Science.gov (United States)

    Fragoso-Maíz, C; Ramos-Martínez, E; García-Martínez, R; Meléndez-Blanco, S

    1993-01-01

    a) to carry out a prospective study of 200 cases of acute appendicitis in adult patients; b) to correlate clinical, laboratory, radiological, and pathological findings. clinical data were collected from all patients; every patient had hematic biometry, urine exam (UE), abdominal radiography, an histopathological study appendix. the patients were 98 males and 102 females; 66.5% were between 15 and 25 years old. All patients had abdominal pain, 56.5% nausea and vomit, 49% fever, 10.5% diarrhea, and 6% urinary symptoms. Post-operatory complications were seen in 24.5%. Leucocytosis greater than 10,000 was found in 82.5%, some alteration of UE in 45%, and abnormal radiography in 56.5%. Histopathological study showed simple appendicitis in 16.5%, hemorrhagic in 8%, purulent in 22%, hemo-purulent in 30.5%, an perforated in 21%. the diagnosis of appendicitis is basically a clinical one, since 17.5% showed normal white-cell count, and 43.5% normal radiography.

  18. HHP treatment of liquid egg at 200-350 MPa

    Science.gov (United States)

    Tóth, A.; Németh, Cs; Palotás, P.; Surányi, J.; Zeke, I.; Csehi, B.; Castillo, L. A.; Friedrich, L.; Balla, Cs

    2017-10-01

    High hydrostatic pressure (HHP) treatment of egg proteins partially limits their sensitivity to pressure. According to the literature, at the 450 MPa level, denaturation of some proteins sets in to the extent that sensory and functional characteristics are impacted. This study involved treating liquid egg (egg white, yolk, and melange) at less than the above-mentioned value, after which the microbiological effect was examined. For the study, pressure pouches were filled with 100ml of raw liquid egg per pouch. Then the samples were treated at 200, 250, 300 and 350 MPa. In each case, the level was reached by increasing pressure at a rate of 100 MPa/min. Measurements were taken at the Corvinus University of Budapest, Faculty of Food Science, Dept. of Refrigeration and Livestock Products Technology RESATO FPU 100-2000 equipment. Denaturation was determined with calorimetric (DSC) tests. From our results, it appears that even at 250 MPa pressure treatment, the viable cell count decreases. Further, it can be said that microbe count went down in the egg white samples at 300-350 MPa, below the impact level. Significant denaturation was not detected during our examinations. In summary, we state that the most HHP-sensitive liquid egg type, egg white, can be pressure treated to reduce microbe count at a level less than that which causes denaturation. Microbe reduction was smaller in yolk and melange, so higher pressure values are appropriate for these products.

  19. [Peganum harmala L. poisoning in Morocco: about 200 cases].

    Science.gov (United States)

    Achour, Sanae; Rhalem, Naima; Khattabi, Asmae; Lofti, Hayat; Mokhtari, Abdelrhani; Soulaymani, Abdelmajid; Turcant, Alain; Bencheikh, Rachida Soulaymani

    2012-01-01

    Peganum harmala L. is commonly used in traditional medicine in Morocco for its sedative and emmenagogue properties but expose to the risk of overdose and poisoning. The aim of our study was to analyze a series of 200 cases of poisoning collected in poison control and pharmacovigilance center of Morocco in order to describe the epidemiological, clinical, therapeutic features and outcome of patients and indicate the toxicity of this plant used primarily for therapeutic purposes. This retrospective study performed over a period of twenty four years from January 1984 to December 2008. The mean age of patients was 24.4±16.8 years with a female predominance (167 women against 33 men). Therapeutic circumstance was found in 32.5%, followed by suicide (28.5%) and abortion (13.5%). The symptomatology was dominated by neurological, gastrointestinal and cardiovascular signs respectively 34.4%, 31.9 % and 15.8%. The evolution has been specified in 114 cases, 7 deaths have been deplored with a fatality rate of 6.2%. © 2012 Société Française de Pharmacologie et de Thérapeutique.

  20. Otology at the Academy of Gondishapur 200-600 CE.

    Science.gov (United States)

    Ruben, Robert J

    2017-12-01

    To investigate the way in which otology was practiced at the Academy of Gondishapur in ancient Persia from 200 to 600 CE. The pertinent literature, using German and English translations of Latin, Greek, Arabic, and Sanskrit documents, was identified and reviewed through the indices of available books and through a PDF search for the following topics: auricle, deaf, deafness, dizziness, ear, hearing, medicine, otitis, pinna, punishment-ear, speech, surgery, vertigo, and voice. The medical school at the Academy of Gondishapur followed the medical and surgical practices of Greece and Rome and, in the 6th century, incorporated those from India as detailed in the Shutra Samhita. This shutra, which originated during the first millennium BCE, detailed many interventions, among which one of the most unusual was the use of a pedicle cheek flap to restore the pinnae. The use of the pedicle flap for pinna restoration appears not have been reported in literature again until 1931, by Jacque Joseph. During the period of late antiquity, medical knowledge of both the east and west was preserved and taught in Persia. Among surgical interventions used during the first millennium BCE in India, knowledge of which passed, through the shutra, to the Sasanian Empire in the 6th century CE, was use of the pedicle cheek flap for pinna reconstruction. Even as late as the Renaissance, the pedicle flap was not known to surgeons in the West, and a pedicle flap, though not a cheek flap, was first incorporated into Western medical practice during the 1930s.

  1. The 200-pc molecular cylinder in the Galactic Centre

    Science.gov (United States)

    Sofue, Yoshiaki

    2017-09-01

    Analysing the 3D structure of the molecular gas distribution in the central 200-pc region of the Galaxy, we show that the expanding molecular ring (EMR, also known as the parallelogram) and the central molecular zone (CMZ) exhibit quite different distributions and kinematics. The EMR composes a bipolar vertical cylinder with the total length as long as ˜170 pc and shows large non-circular velocities. On the contrary, the CMZ is distributed in a nearly rigid-body rotating ring and arms tightly concentrated near the galactic plane with full thickness less than ˜30 pc. Furthermore, the mass and density ratios of the EMR to CMZ are as small as ˜0.13 and 0.04, respectively. We discuss the origins of the EMR and CMZ based on the bar and explosion models. We suggest that the EMR's large vertical extent can be explained by a cylindrical shock wave model driven by an explosive activity in the Galactic Centre.

  2. Design Considerations for the LHC 200 MHz RF System

    CERN Document Server

    Boussard, Daniel; Kindermann, H P; Linnecar, Trevor Paul R; Marque, S; Tückmantel, Joachim

    2000-01-01

    The longitudinal beam transfer from the SPS into the LHC 400 MHz buckets will not be free of losses without a lower frequency capture system and a fast longitudinal damping system in LHC. We present a complete study of a combined system using four identical copper cavities at 200 MHz delivering 3 MV total CW voltage and having still enough bandwidth to achieve fast longitudinal damping. The shape of a cavity was designed according to the accelerating mode performance, its tuning and the higher order mode spectrum with respect to the LHC beam lines and their possible attenuation. The possibility to park the cavities during coast was included. The local heat load and the corresponding cooling water distribution as well as deformations were studied and techniques to build the cavity with all ports at low cost are proposed. The parameters of the RF generators, couplers and detuning are determined. Simulations of the total LHC RF system incorporating real delays, generator bandwidth and the control loops confirm t...

  3. 6 CFR 27.200 - Information regarding security risk for a chemical facility.

    Science.gov (United States)

    2010-01-01

    ... information from chemical facilities that may reflect potential consequences of or vulnerabilities to a... chemical facility. 27.200 Section 27.200 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Chemical Facility Security Program § 27.200 Information...

  4. 34 CFR 200.39 - Responsibilities resulting from identification for school improvement.

    Science.gov (United States)

    2010-07-01

    ... school improvement plan in accordance with § 200.41. (b) If a school fails to make AYP by the end of the... school improvement. 200.39 Section 200.39 Education Regulations of the Offices of the Department of... ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Improving Basic Programs Operated by Local Educational Agencies...

  5. Immunomodulator CD200 promotes neurotrophic activity by interacting with and activating the fibroblast growth factor receptor

    DEFF Research Database (Denmark)

    Pankratova, Stanislava; Björnsdóttir, Halla; Christensen, Claus

    2016-01-01

    origin. A recently solved crystal structure of the CD200-CD200R ectodomain complex suggests involvement of the first immunoglobulin (Ig)-like modules in ligand-receptor binding, resulting in the inhibition of myeloid cell function. In the central nervous system, CD200 has been implicated...

  6. 33 CFR 167.200 - In the approaches to Chesapeake Bay Traffic Separation Scheme: General.

    Science.gov (United States)

    2010-07-01

    ... Bay Traffic Separation Scheme: General. 167.200 Section 167.200 Navigation and Navigable Waters COAST... SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.200 In the approaches to Chesapeake Bay Traffic Separation Scheme: General. (a) The traffic...

  7. 24 CFR 200.1303 - Annual income exclusions for the Rent Supplement Program.

    Science.gov (United States)

    2010-04-01

    ... Rent Supplement Program. 200.1303 Section 200.1303 Housing and Urban Development Regulations Relating... Administrative Matters § 200.1303 Annual income exclusions for the Rent Supplement Program. (a) The exclusions to annual income described in 24 CFR 5.609(c) apply to those rent supplement contracts governed by the...

  8. 17 CFR 200.19a - Director of the Division of Trading and Markets.

    Science.gov (United States)

    2010-04-01

    ... Trading and Markets. 200.19a Section 200.19a Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.19a Director of the Division of Trading and Markets. The Director of the Division of Trading and Markets is responsible to the Commission for the administration and execution of...

  9. 38 CFR Appendix C to Part 200 - Actions Requiring Environmental Impact Statement

    Science.gov (United States)

    2010-07-01

    ... Environmental Impact Statement C Appendix C to Part 200 Pensions, Bonuses, and Veterans' Relief ARMED FORCES RETIREMENT HOME COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL POLICY ACT Pt. 200, App. C Appendix C to Part 200—Actions Requiring Environmental Impact Statement The following actions are considered to be major Federal...

  10. 9 CFR 202.200 - Scope and applicability of rules of practice.

    Science.gov (United States)

    2010-01-01

    ....200 Scope and applicability of rules of practice. The Uniform Rules of Practice for the Department of... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Scope and applicability of rules of practice. 202.200 Section 202.200 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS...

  11. 17 CFR 200.18 - Director of Division of Corporation Finance.

    Science.gov (United States)

    2010-04-01

    ... Corporation Finance. 200.18 Section 200.18 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.18 Director of Division of Corporation Finance. The Director of the Division of Corporation Finance is responsible to the Commission for the administration of all matters (except those...

  12. 12 CFR 550.200 - Must I review a prospective account before I accept it?

    Science.gov (United States)

    2010-01-01

    ... accept it? 550.200 Section 550.200 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE... § 550.200 Must I review a prospective account before I accept it? Before accepting a prospective fiduciary account, you must review it to determine whether you can properly administer the account. ...

  13. Alternative splicing of CD200 is regulated by an exonic splicing enhancer and SF2/ASF.

    Science.gov (United States)

    Chen, Zhiqi; Ma, Xuezhong; Zhang, Jianhua; Hu, Jim; Gorczynski, Reginald M

    2010-10-01

    CD200, a type I membrane glycoprotein, plays an important role in prevention of inflammatory disorders, graft rejection, autoimmune diseases and spontaneous fetal loss. It also regulates tumor immunity. A truncated CD200 (CD200(tr)) resulting from alternative splicing has been identified and characterized as a functional antagonist to full-length CD200. Thus, it is important to explore the mechanism(s) controlling alternative splicing of CD200. In this study, we identified an exonic splicing enhancer (ESE) located in exon 2, which is a putative binding site for a splicing regulatory protein SF2/ASF. Deletion or mutation of the ESE site decreased expression of the full-length CD200. Direct binding of SF2/ASF to the ESE site was confirmed by RNA electrophoretic mobility shift assay (EMSA). Knockdown of expression of SF2/ASF resulted in the same splicing pattern as seen after deletion or mutation of the ESE, whereas overexpression of SF2/ASF increased expression of the full-length CD200. In vivo studies showed that viral infection reversed the alternative splicing pattern of CD200 with increased expression of SF2/ASF and the full-length CD200. Taken together, our data suggest for the first time that SF2/ASF regulates the function of CD200 by controlling CD200 alternative splicing, through direct binding to an ESE located in exon 2 of CD200.

  14. 24 CFR 200.926c - Model code provisions for use in partially accepted code jurisdictions.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Model code provisions for use in partially accepted code jurisdictions. 200.926c Section 200.926c Housing and Urban Development Regulations... Minimum Property Standards § 200.926c Model code provisions for use in partially accepted code...

  15. 24 CFR 200.925b - Residential and institutional building code comparison items.

    Science.gov (United States)

    2010-04-01

    ...); (6) Individual unit smoke detectors; (7) Building alarm systems; (8) Highrise criteria; (b) Light and... building code comparison items. 200.925b Section 200.925b Housing and Urban Development Regulations... Minimum Property Standards § 200.925b Residential and institutional building code comparison items. HUD...

  16. 34 CFR 200.75 - Special procedures for allocating concentration grant funds in small States.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Special procedures for allocating concentration grant... Allocations to Leas § 200.75 Special procedures for allocating concentration grant funds in small States. (a... concentration grants among eligible LEAs in the State in accordance with §§ 200.72 through 200.74, as applicable...

  17. 17 CFR 200.13a - The Secretary of the Commission.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false The Secretary of the Commission. 200.13a Section 200.13a Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General Organization § 200.13a The Secretary of the...

  18. 41 CFR 301-71.200 - Who must review and sign travel claims?

    Science.gov (United States)

    2010-07-01

    ... travel claims? 301-71.200 Section 301-71.200 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES AGENCY RESPONSIBILITIES 71-AGENCY TRAVEL ACCOUNTABILITY REQUIREMENTS Travel Claims for Reimbursement § 301-71.200 Who must review and sign travel claims...

  19. 29 CFR 780.200 - Inclusion of forestry or lumbering operations in agriculture is limited.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Inclusion of forestry or lumbering operations in agriculture is limited. 780.200 Section 780.200 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR... Lumbering Operations § 780.200 Inclusion of forestry or lumbering operations in agriculture is limited...

  20. 9 CFR 113.200 - General requirements for killed virus vaccines.

    Science.gov (United States)

    2010-01-01

    ... vaccines. 113.200 Section 113.200 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... REQUIREMENTS Killed Virus Vaccines § 113.200 General requirements for killed virus vaccines. When prescribed in an applicable Standard Requirement or in the filed Outline of Production, a killed virus vaccine...

  1. 76 FR 56680 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes; Model A340-200 and...

    Science.gov (United States)

    2011-09-14

    ... Model A330-200 and -300 Series Airplanes; Model A340-200 and -300 Series Airplanes; Model A340-500 and -600 Series Airplanes AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed...: Vladimir Ulyanov, Aerospace Engineer, International Branch, ANM-116, Transport Airplane Directorate, FAA...

  2. 75 FR 15353 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes, and A340-200, -300...

    Science.gov (United States)

    2010-03-29

    ... Directives; Airbus Model A330-200 and -300 Series Airplanes, and A340-200, -300, -500 and -600 Series... all applicable corrective actions (replacing damaged parts). This supplemental NPRM would also require... of time that corresponds to the normal scheduled maintenance for most affected operators. In light of...

  3. 75 FR 31282 - Airworthiness Directives; Airbus Model A319-100, A320-200, A321-100, and A321-200 Series Airplanes

    Science.gov (United States)

    2010-06-03

    ...-087-AD; Amendment 39-14582; AD 2006-09-11] RIN 2120-AA64 Airworthiness Directives; Airbus Model A319... May 12, 2006. The error resulted in an incorrect component maintenance manual number. This AD applies to certain Airbus Model A319-100, A320-200, A321-100, and A321-200 series airplanes. This AD requires...

  4. Enthalpy measurement of coal-derived liquids. Final technical progress report. [200 to 740/sup 0/F and 200 to 1500 psia

    Energy Technology Data Exchange (ETDEWEB)

    Kidnay, A.J.; Yesavage, V.F.

    1981-05-01

    This final report presents the results of the enthalpy measurements on the model compound m-cresol. The measurements cover the temperature range 200 to 740/sup 0/F and the pressure range 200 to 1500 psia. These data are compared with earlier data taken on m-cresol and with other thermophysical properties taken from the literature.

  5. Post-200-ka Pyroclastic Eruptions of the Yellowstone Plateau

    Science.gov (United States)

    Morgan, L. A.; Shanks, W. C.

    2010-12-01

    Pyroclastic deposits intercalated in post-Yellowstone-caldera rhyolitic lava flows form a minor component of the total volume of high-silica rhyolites erupted between 200 and 70 ka. Such events produced significant volumes of ash, fast-moving pyroclastic flows, and volcanic gases during young eruptions on the Plateau. Thus, while these were less common events, it is important to know the details of these deposits, including the number and frequency of eruptions, their sources, and possible associations or relations to other volcanic or tectonic events. The tuff of Bluff Point is the largest of these Yellowstone Caldera. Eruption of the tuff of Bluff Point, around 170-200 ka, is estimated from current maps to be ~50 km3 and resulted in collapse of the 10-km-wide West Thumb caldera, centered in the western-most basin of Yellowstone Lake. Large amounts of water derived from an ancestral Yellowstone Lake may have been involved in the eruption, suggested by large blocks of glass and abundant smaller fragments of obsidian incorporated into the ignimbrite. The oval-shaped West Thumb caldera occurs within the much larger and older Yellowstone Caldera and has dimensions comparable to Crater Lake (Oregon). New mapping, variable 40Ar/39Ar ages, and differences in mineralogy, grain size, and component data between key exposures all suggest that the tuff of Bluff Point, as mapped, represents as many as three pyroclastic eruptions. These eruptions may have occurred over a 20- to 40-k.y. interval, which may explain enigmatic age discrepancies. Stratigraphic, mineralogical, geochemical, radiometric, granulometric, and component analyses are being employed to unravel the details and origins of these pyroclastic deposits, which are rich in glass, pumice, ash, crystal, and lithic fragments. Several pumice morphologies are present in each deposit. Pyroclastic fallout, sinter, and volcaniclastic-rich alluvial deposits are intercalated between individual ignimbrite deposits; these

  6. Ascending phlebography of the legs with Solutrast 200

    Energy Technology Data Exchange (ETDEWEB)

    Tuengerthal, S.

    1984-10-01

    This is a report on an open clinical test with the X-ray contrast medium Jopamidol, which is non-ionic and therefore osmolarity-reduced. It has an iodine content of 200 mg iodine/ml and was found to be useful for the demonstration of the peripheral and central veins. 92.9 per cent of all examinations, using an injected dose of mostly 50 ml of the agent, permitted satisfactory contrasting of the veins of the lower extremities including the pelvic veins. Because the contrast solution flows off quickly it is possible in spite of the low iodine content to obtain a fair demonstration of discrete alterations of the vessel walls of peripheral veins, and to document the veins, in the abdomen at the same time. The systemic tolerance of the agent is good. 96.7 per cent of the patients showed no symptoms after the contrast medium was injected, one patient exhibited mild signs of hypergenetic reaction to the X-ray contrast medium (urticaria). Side effects were seen in 3.3 per cent of the patients and were in all cases non-threatening. The local tolerance is excellent. 86.6 per cent did not experience disagreeable sensations in the extremity examined. Only one patient reported great pain during the examination. Clinical and nuclear investigations after the phlebography did not suffer from thrombophlebitic complications. The fastness of the investigation and good local tolerance of the contrast solution reduce the risk involved with the phlebography especially in at-risk patients.

  7. PEROXIDE DESTRUCTION TESTING FOR THE 200 AREA EFFLUENT TREATMENT FACILITY

    Energy Technology Data Exchange (ETDEWEB)

    HALGREN DL

    2010-03-12

    The hydrogen peroxide decomposer columns at the 200 Area Effluent Treatment Facility (ETF) have been taken out of service due to ongoing problems with particulate fines and poor destruction performance from the granular activated carbon (GAC) used in the columns. An alternative search was initiated and led to bench scale testing and then pilot scale testing. Based on the bench scale testing three manganese dioxide based catalysts were evaluated in the peroxide destruction pilot column installed at the 300 Area Treated Effluent Disposal Facility. The ten inch diameter, nine foot tall, clear polyvinyl chloride (PVC) column allowed for the same six foot catalyst bed depth as is in the existing ETF system. The flow rate to the column was controlled to evaluate the performance at the same superficial velocity (gpm/ft{sup 2}) as the full scale design flow and normal process flow. Each catalyst was evaluated on peroxide destruction performance and particulate fines capacity and carryover. Peroxide destruction was measured by hydrogen peroxide concentration analysis of samples taken before and after the column. The presence of fines in the column headspace and the discharge from carryover was generally assessed by visual observation. All three catalysts met the peroxide destruction criteria by achieving hydrogen peroxide discharge concentrations of less than 0.5 mg/L at the design flow with inlet peroxide concentrations greater than 100 mg/L. The Sud-Chemie T-2525 catalyst was markedly better in the minimization of fines and particle carryover. It is anticipated the T-2525 can be installed as a direct replacement for the GAC in the peroxide decomposer columns. Based on the results of the peroxide method development work the recommendation is to purchase the T-2525 catalyst and initially load one of the ETF decomposer columns for full scale testing.

  8. Calculo de tanque de PRFV de 200 000 litros de capacidad. // 200 000 liters capacity PRFV tank calculation.

    Directory of Open Access Journals (Sweden)

    J. García de la Figal Costales

    2002-01-01

    Full Text Available La tarea que se acomete es el cálculo a resistencia y rigidez de un tanque para el almacenamiento de agua, de 200 000 litrosde capacidad, construido de plástico reforzado con fibras de vidrio, PRFV. El mismo es cilíndrico vertical, de 8 metros dediámetro por 4.2 metros de altura. Los materiales seleccionados para la conformación de las láminas con las que se haránlos laminados de PRFV, fueron: resina poliéster isosftálica, y fibras de vidrio E.La carga fundamental a soportar por el tanque será la presión debida a la columna de agua en su interior, pero por estar a laintemperie y en zona de playa, se considerará también la acción de las dilataciones debidas a la temperatura, así como laacción de un ciclón.Palabras claves: resistencia, recipiente, composites, elementos finitos._____________________________________________________________________________Abstract.The stress and strains calculation of a water reinforced fiber glass container is carried out by means of a modern FiniteElement program, because the high complexity of calculus. The soported main load is the pressure caused by the column ofwater.Key words: Resistance, vessels, composites, finite elements.

  9. Implantes orbitarios de HAP-200: Experiencia en 100 casos Orbital implants of HAP-200: Experience in 100 cases

    Directory of Open Access Journals (Sweden)

    Nereyda Martínez Suárez

    2002-06-01

    Full Text Available Exponemos nuestra experiencia en los primeros 100 casos, en los cuales utilizamos implantes orbitarios confeccionados en Cuba con hidroxiapatita porosa coralina (HAP-200, en el período comprendido entre 1995-2000. Nuestra casuística estuvo enmarcada entre los 5 y 65 años de edad, predominando los grupos de edades de 15 a 35 años con 63 casos, el 72 % correspondió al sexo masculino. Los traumatismos primaron como causa de pérdida del globo ocular (80 %. Efectuamos 5 tipos de técnicas quirúrgicas, 22 enucleaciones, 46 evisceraciones (26 con y 9 sin conservación corneal respectivamente, 11 con cuadrisección escleral y 32 reconstrucciones de cavidades antiguas (implantes secundarios. En la mayoría de los pacientes operados los síntomas y signos posoperatorios fueron locales y catalogados de ligeros, que desaparecieron en la primera semana. Observamos dentro de las complicaciones 12 dehiscencias conjuntivales, 10 exposiciones de los implantes, 2 hipercorrecciones, 1 hipocorrección y 1 quiste conjuntival. La gammagrafía orbitaria demostró crecimiento fibrovascular en la totalidad de los pacientes sometidos a dicha investigación. Los resultados cosméticos evaluados fueron la conservación del surco orbitario y la motilidad del muñón que se consideraron satisfactorios, así como la tolerancia al material implantado que fue buena en el 93 % de los casos al cabo de los 2,5 años.We explain our experience with the first 100 cases in whom orbital implants made in Cuba with coralline porous hydroxyapatite (PHA-200 were placed between 1995 and 2000. Our casuistics comprised patients aged 5-65. It was observed a predominance of the age groups 15-35 with 63 cases. 72 % were males. Traumas prevailed as the main cause of eyeball loss (80 %. 5 types of surgical techniques were performed: 22 enucleations, 46 eviscerations (26 with and 9 without corneal conservation, respectively, 11 with scleral cuadrisection and 32 reconstructions of old

  10. Characterization of biofilm in 200W fluidized bed reactors

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Michelle H. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Saurey, Sabrina D. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Lee, Brady D. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Parker, Kent E. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Eisenhauer, Emalee E. R. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Cordova, Elsa A. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Golovich, Elizabeth C. [Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

    2014-09-29

    Contaminated groundwater beneath the 200 West Area at the Hanford Site in Southeast Washington is currently being treated using a pump and treat system to remove organics, inorganics, radionuclides, and metals. A granular activated carbon-based fluidized bed reactor (FBR) has been added to remove nitrate, hexavalent chromium and carbon tetrachloride. Initial analytical results indicated the microorganisms effectively reduced many of the contaminants to less than cleanup levels. However shortly thereafter operational upsets of the FBR include carbon carry over, over production of microbial extracellular polymeric substance (biofilm) materials, and over production of hydrogen sulfide. As a result detailed investigations were undertaken to understand the functional diversity and activity of the microbial community present in the FBR over time. Molecular analyses including terminal restriction fragment length polymorphism analysis, quantitative polymerase chain reaction and fluorescent in situ hybridization analyses were performed on the microbial community extracted from the biofilm within the bed and from the inoculum, to determine functional dynamics of the FBR bed over time and following operational changes. Findings from these analyses indicated: 1) the microbial community within the bed was completely different than community used for inoculation, and was likely from the groundwater; 2) analyses early in the testing showed an FBR community dominated by a few Curvibacter and Flavobacterium species; 3) the final sample taken indicated that the microbial community in the FBR bed had become more diverse; and 4) qPCR analyses indicated that bacteria involved in nitrogen cycling, including denitrifiers and anaerobic ammonia oxidizing bacteria, were dominant in the bed. These results indicate that molecular tools can be powerful for determining functional diversity within FBR type reactors. Coupled with micronutrient, influent and effluent chemistry

  11. MicroRNA-200c plays an oncogenic role in nasopharyngeal carcinoma by targeting PTEN.

    Science.gov (United States)

    Zhang, Zhen-Zhen; Cao, Heng-Chang; Huang, Dong-Li; Wu, Qi; Chen, Xiao-Fan; Wan, Jun; Zhang, Wei

    2017-05-01

    Recent studies suggested that microRNA-200 family microRNAs play critical roles in cancer initiation and metastasis. The underlying mechanism remained elusive. In this study, we show that microRNA-200c is upregulated in nasopharyngeal carcinoma cells. Manipulation of microRNA-200c levels affected cell growth, migration, and invasion in nasopharyngeal carcinoma cell lines. Furthermore, PTEN was identified as a direct target of microRNA-200c. Overexpression of PTEN resulted in similar effects to those of anti-microRNA-200c transfection. In vivo suppression of microRNA-200c level reduced tumor growth in mice. Overall, our data suggest that microRNA-200c plays an oncogenic role in nasopharyngeal carcinoma by targeting PTEN.

  12. Derivation of Soil Screening Guidelines for Gross Alpha/Beta Radioactivity for United States Air Force Deployment Sites

    Science.gov (United States)

    2007-04-19

    the emission of 7 alpha particles and 4 beta particles. Three radionuclides ( francium -223, astatine-215, and polonium-211) are not listed below...no no Uranium-233 159,200 y alpha yes no Thorium-229 7,300 y alpha yes no Radium-225 14.9 d beta no no Actinium-225 10.0 d alpha no no Francium

  13. Pulsar polarisation below 200 MHz: Average profiles and propagation effects

    Science.gov (United States)

    Noutsos, A.; Sobey, C.; Kondratiev, V. I.; Weltevrede, P.; Verbiest, J. P. W.; Karastergiou, A.; Kramer, M.; Kuniyoshi, M.; Alexov, A.; Breton, R. P.; Bilous, A. V.; Cooper, S.; Falcke, H.; Grießmeier, J.-M.; Hassall, T. E.; Hessels, J. W. T.; Keane, E. F.; Osłowski, S.; Pilia, M.; Serylak, M.; Stappers, B. W.; ter Veen, S.; van Leeuwen, J.; Zagkouris, K.; Anderson, K.; Bähren, L.; Bell, M.; Broderick, J.; Carbone, D.; Cendes, Y.; Coenen, T.; Corbel, S.; Eislöffel, J.; Fender, R.; Garsden, H.; Jonker, P.; Law, C.; Markoff, S.; Masters, J.; Miller-Jones, J.; Molenaar, G.; Osten, R.; Pietka, M.; Rol, E.; Rowlinson, A.; Scheers, B.; Spreeuw, H.; Staley, T.; Stewart, A.; Swinbank, J.; Wijers, R.; Wijnands, R.; Wise, M.; Zarka, P.; van der Horst, A.

    2015-04-01

    Aims: We present the highest-quality polarisation profiles to date of 16 non-recycled pulsars and four millisecond pulsars, observed below 200 MHz with the LOFAR high-band antennas. Based on the observed profiles, we perform an initial investigation of expected observational effects resulting from the propagation of polarised emission in the pulsar magnetosphere and the interstellar medium. Methods: The polarisation data presented in this paper have been calibrated for the geometric-projection and beam-shape effects that distort the polarised information as detected with the LOFAR antennas. We have used RM Synthesis to determine the amount of Faraday rotation in the data at the time of the observations. The ionospheric contribution to the measured Faraday rotation was estimated using a model of the ionosphere. To study the propagation effects, we have compared our low-frequency polarisation observations with archival data at 240, 400, 600, and 1400 MHz. Results: The predictions of magnetospheric birefringence in pulsars have been tested using spectra of the pulse width and fractional polarisation from multifrequency data. The derived spectra offer only partial support for the expected effects of birefringence on the polarisation properties, with only about half of our sample being consistent with the model's predictions. It is noted that for some pulsars these measurements are contaminated by the effects of interstellar scattering. For a number of pulsars in our sample, we have observed significant variations in the amount of Faraday rotation as a function of pulse phase, which is possibly an artefact of scattering. These variations are typically two orders of magnitude smaller than that observed at 1400 MHz by Noutsos et al. (2009), for a different sample of southern pulsars. In this paper we present a possible explanation for the difference in magnitude of this effect between the two frequencies, based on scattering. Finally, we have estimated the magnetospheric

  14. High serum soluble CD200 levels in patients with autosomal dominant polycystic kidney disease.

    Science.gov (United States)

    Sari, Funda; Gumuslu, Saadet; Cetinkaya, Ramazan; Sarikaya, Metin; Yalcin, Arzu Didem

    2017-04-01

    CD200 is a novel immune-effective molecule, existing in a cell membrane-bound form, as well as in a soluble form in serum, which performs to modulate inflammatory and acquired immune responses. Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of large renal cysts and progressive loss of renal function. As defects in cell cycle arrest and apoptosis of renal tubular epithelial cells occur in ADPKD, we asked whether serum soluble CD200 might underlie and effect on ADPKD. Serum soluble CD200 levels were measured in 44 patients with ADPKD and 24 healthy volunteers. Concentrations of soluble CD200 in the serum samples were quantified using an ELISA kit. The mean serum soluble CD200 levels were higher in patients with ADPKD than in the control group (71.4±29.2 and 21.4±5.6 pg/mL, psoluble CD200 levels and glomerular filtration rate (r=0.772, psoluble CD200 levels and serum creatinine levels (r=-0.761, psoluble CD200 levels were lower in patients with stage 5 chronic kidney disease (CKD) than in patients with stages 1-2 (psoluble CD200 levels were similar in patients with stages 1-2, 3, and 4 CKD (p>0.05). Our results show that patients with ADPKD have activated soluble CD200 levels which were related to renal function and inflammation. Copyright © 2017 American Federation for Medical Research.

  15. WTG Energy Systems' MP1-200 200 kilowatt wind turbine generator. [a fixed pitch rotor configuration driving a synchronous generator

    Science.gov (United States)

    Spaulding, A. P., Jr.

    1979-01-01

    The preliminary design criteria of the MP1-200 wind turbine are given along with a brief description of the wind turbine generator. Performance and operational experience and cost factors are included. Recommendations for additional research are listed.

  16. Over-expression of CD200 predicts poor prognosis in MDS.

    Science.gov (United States)

    Chen, Jia-Xi; Mei, Li-Ping; Chen, Bao-Guo; Wang, Dong-Lian; Luo, Wen-da; Luo, Li-Fei; Lu, Ruyue; Zheng, Rui; Zhang, Li

    2017-05-01

    We studied the expression of CD200 in a series of 101 patients with diagnosis of myelodysplastic syndrome (MDS), to evaluate its impact on outcome and its possible association with other known prognostic factors. The CD200 was detected by flow cytometry, and the chromosome karyotypes were determined by G banding respectively. The Mann-Whitney U test was used to analyze the association among CD200 expression and clinical features. In addition, the overall survival and AML transformation of the MDS patients according to the expression level of CD200 was also explored. Overall, the flow cytometric analyses confirmed that expression of CD200 was high in this patient cohort compared to normal BM (pMDS according to IPSS risk(PMDS in our study indicated that patients with high expression level of CD200 had a shorter overall survival and a high Leukemic transformation than those with low expression (pMDS. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. 34 CFR 200.56 - Definition of “highly qualified teacher.”

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Definition of âhighly qualified teacher.â 200.56... Paraprofessionals § 200.56 Definition of “highly qualified teacher.” A teacher described in § 200.55(a) and (b)(1... test), subject knowledge and teaching skills in reading/language arts, writing, mathematics, and other...

  18. 29 CFR 2530.200b-4 - One-year break in service.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false One-year break in service. 2530.200b-4 Section 2530.200b-4... General Provisions § 2530.200b-4 One-year break in service. (a) Computation period. (1) Under sections 202... that an employee incurs a one-year break in service for a computation period or periods if the employee...

  19. miR-200a-3p promotes β-Amyloid-induced neuronal apoptosis ...

    Indian Academy of Sciences (India)

    Qi-Shun Zhang

    2017-07-20

    Jul 20, 2017 ... The aberrantly expressed microRNAs (miRNAs) including miR-200a-3p have been reported in the brains of Alzheimer's disease (AD) patients in recent researches. Nevertheless, the role of miR-200a-3p in AD has not been characterized. The purpose of this study was to examine whether miR-200a-3p ...

  20. SRP engineering and design history, Vol III, 200 F and H Areas

    Energy Technology Data Exchange (ETDEWEB)

    Banick, C.J.

    2000-04-17

    This volume combines the record of events relating to the development of design for both the 200-F and H Areas. Chronologically, the definition of plant facilities was first established for the 200-F Area. The second area, 200-H, was projected initially to be a supplementary plutonium separations facility. This history explains the differences in character and capacity of the manufacturing facilities in both areas as production requirements and experience with separations processes advanced.

  1. miR-200a-3p promotes b-Amyloid-induced neuronal apoptosis ...

    Indian Academy of Sciences (India)

    The aberrantly expressed microRNAs (miRNAs) including miR-200a-3p have been reported in the brains of Alzheimer'sdisease (AD) patients in recent researches. Nevertheless, the role of miR-200a-3p in AD has not been characterized. Thepurpose of this study was to examine whether miR-200a-3p regulated b-Ameyloid ...

  2. Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish

    Directory of Open Access Journals (Sweden)

    Yuan Liu

    2015-01-01

    Full Text Available Purpose. The small nuclear ribonucleoprotein 200 kDa (SNRNP200 gene is a fundamental component for precursor message RNA (pre-mRNA splicing and has been implicated in the etiology of autosomal dominant retinitis pigmentosa (adRP. This study aims to determine the consequences of knocking down Snrnp200 in zebrafish. Methods. Expression of the Snrnp200 transcript in zebrafish was determined via whole mount in situ hybridization. Morpholino oligonucleotide (MO aiming to knock down the expression of Snrnp200 was injected into zebrafish embryos, followed by analyses of aberrant splicing and expression of the U4/U6-U5 tri-small nuclear ribonucleoproteins (snRNPs components and retina-specific transcripts. Systemic changes and retinal phenotypes were further characterized by histological study and immunofluorescence staining. Results. Snrnp200 was ubiquitously expressed in zebrafish. Knocking down Snrnp200 in zebrafish triggered aberrant splicing of the cbln1 gene, upregulation of other U4/U6-U5 tri-snRNP components, and downregulation of a panel of retina-specific transcripts. Systemic defects were found correlated with knockdown of Snrnp200 in zebrafish. Only demorphogenesis of rod photoreceptors was detected in the initial stage, mimicking the disease characteristics of RP. Conclusions. We conclude that knocking down Snrnp200 in zebrafish could alter regular splicing and expression of a panel of genes, which may eventually trigger rod defects.

  3. Comparison of the Nellcor N-200 and N-3000 pulse oximeters during simulated postoperative activities

    DEFF Research Database (Denmark)

    Lie, C; Kehlet, H; Rosenberg, J

    1997-01-01

    Twenty-six healthy volunteers were monitored simultaneously with the Nellcor N-200 and N-3000 pulse oximeters during nonhypoxaemic simulated postoperative activity. The overall number of registered events (hypoxaemic episodes or loss of signal) was fewer with the N-3000 than with the N-200 (8 vs...... to loss of signal were significantly rarer with the N-3000 than with the N-200 (3 vs. 13, p = 0.001). The Nellcor N-3000 oximeter may offer an advantage over the N-200 model when monitoring patients in the postoperative period....

  4. RNA recognition by a human antibody against brain cytoplasmic 200 RNA

    Science.gov (United States)

    Jung, Euihan; Lee, Jungmin; Hong, Hyo Jeong; Park, Insoo; Lee, Younghoon

    2014-01-01

    Diverse functional RNAs participate in a wide range of cellular processes. The RNA structure is critical for function, either on its own or as a complex form with proteins and other ligands. Therefore, analysis of the RNA conformation in cells is essential for understanding their functional mechanisms. However, no appropriate methods have been established as yet. Here, we developed an efficient strategy for panning and affinity maturation of anti-RNA human monoclonal antibodies from a naïve antigen binding fragment (Fab) combinatorial phage library. Brain cytoplasmic 200 (BC200) RNA, which is also highly expressed in some tumors, was used as an RNA antigen. We identified MabBC200-A3 as the optimal binding antibody. Mutagenesis and SELEX experiments showed that the antibody recognized a domain of BC200 in a structure- and sequence-dependent manner. Various breast cancer cell lines were further examined for BC200 RNA expression using conventional hybridization and immunoanalysis with MabBC200-A3 to see whether the antibody specifically recognizes BC200 RNA among the total purified RNAs. The amounts of antibody-recognizable BC200 RNA were consistent with hybridization signals among the cell lines. Furthermore, the antibody was able to discriminate BC200 RNA from other RNAs, supporting the utility of this antibody as a specific RNA structure-recognizing probe. Intriguingly, however, when permeabilized cells were subjected to immunoanalysis instead of purified total RNA, the amount of antibody-recognizable RNA was not correlated with the cellular level of BC200 RNA, indicating that BC200 RNA exists as two distinct forms (antibody-recognizable and nonrecognizable) in breast cancer cells and that their distribution depends on the cell type. Our results clearly demonstrate that anti-RNA antibodies provide an effective novel tool for detecting and analyzing RNA conformation. PMID:24759090

  5. Shaping Physiological Indices, Swimming Technique, and Their Influence on 200m Breaststroke Race in Young Swimmers

    Directory of Open Access Journals (Sweden)

    Marek Strzala

    2015-03-01

    Full Text Available The aim of this study was to investigate somatic properties and physiological capacity, and analyze kinematic parameters in the 200 m breaststroke swimming race. Twenty-seven male swimmers participated in the study. They were 15.7±1.98 years old. Their average height was 1.80 ± 0.02 m and lean body mass (LBM was 62.45 ± 8.29 kg. Physiological exercise capacity was measured in two separate 90 sec. all-out tests, one for the arms and second for legs. During the tests total work of arm cranking (TWAR and cycling (TWLG as well as peak of VO2 for arm (VO2peakAR and leg (VO2peakLG were measured. The underwater swimmers body movements were recorded during the all-out swimming 200m breaststroke speed test using an underwater camera installed on a portable trolley. The swimming kinematic parameters and propulsive or non-propulsive movement phases of the arms and legs as well as average speed (V200, surface speed (V200surface and swimming speed in turn zones (V200turns were extracted. V200surface was significantly related to the percentage of leg propulsion and was shown to have large effect on VO2peakLG in the Cohen analysis. V200turns depended significantly on the indicators of physiological performance and body structure: TWAR, VO2peak LG and LBM, LBM, which in turn strongly determined the measured results of TWAR, TWLG, VO2peakAR and VO2peakLG. The V200turns and V200surface were strongly associated with V200, 0.92, p < 0.001 and 0.91, p < 0.001 respectively. In each lap of the 200m swimming there was an increased percentage of propulsion of limb movement observed simultaneously with a reduction in the gliding phase in the breaststroke cycles.

  6. RNA recognition by a human antibody against brain cytoplasmic 200 RNA.

    Science.gov (United States)

    Jung, Euihan; Lee, Jungmin; Hong, Hyo Jeong; Park, Insoo; Lee, Younghoon

    2014-06-01

    Diverse functional RNAs participate in a wide range of cellular processes. The RNA structure is critical for function, either on its own or as a complex form with proteins and other ligands. Therefore, analysis of the RNA conformation in cells is essential for understanding their functional mechanisms. However, no appropriate methods have been established as yet. Here, we developed an efficient strategy for panning and affinity maturation of anti-RNA human monoclonal antibodies from a naïve antigen binding fragment (Fab) combinatorial phage library. Brain cytoplasmic 200 (BC200) RNA, which is also highly expressed in some tumors, was used as an RNA antigen. We identified MabBC200-A3 as the optimal binding antibody. Mutagenesis and SELEX experiments showed that the antibody recognized a domain of BC200 in a structure- and sequence-dependent manner. Various breast cancer cell lines were further examined for BC200 RNA expression using conventional hybridization and immunoanalysis with MabBC200-A3 to see whether the antibody specifically recognizes BC200 RNA among the total purified RNAs. The amounts of antibody-recognizable BC200 RNA were consistent with hybridization signals among the cell lines. Furthermore, the antibody was able to discriminate BC200 RNA from other RNAs, supporting the utility of this antibody as a specific RNA structure-recognizing probe. Intriguingly, however, when permeabilized cells were subjected to immunoanalysis instead of purified total RNA, the amount of antibody-recognizable RNA was not correlated with the cellular level of BC200 RNA, indicating that BC200 RNA exists as two distinct forms (antibody-recognizable and nonrecognizable) in breast cancer cells and that their distribution depends on the cell type. Our results clearly demonstrate that anti-RNA antibodies provide an effective novel tool for detecting and analyzing RNA conformation. © 2014 Jung et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  7. 9 CFR 201.200 - Sale of livestock to a packer on credit.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Sale of livestock to a packer on credit. 201.200 Section 201.200 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS... credit to ________, a packer, and I understand that in doing so I will have no rights under the trust...

  8. 13 CFR 123.200 - Am I eligible to apply for a physical disaster business loan?

    Science.gov (United States)

    2010-01-01

    ..., corporation, limited liability company, or other legal entity recognized under State law. Your business' size... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Am I eligible to apply for a physical disaster business loan? 123.200 Section 123.200 Business Credit and Assistance SMALL BUSINESS...

  9. 34 CFR 200.47 - SEA responsibilities for supplemental educational services.

    Science.gov (United States)

    2010-07-01

    ... School Improvement § 200.47 SEA responsibilities for supplemental educational services. (a) If one or... educational services plans under § 200.46(b)(2)(i); (iii) Has contributed to increasing students' academic... 34 Education 1 2010-07-01 2010-07-01 false SEA responsibilities for supplemental educational...

  10. 34 CFR 200.89 - MEP allocations; Re-interviewing; Eligibility documentation; and Quality control.

    Science.gov (United States)

    2010-07-01

    ... of recruiters, size or growth in local migratory child population, effectiveness of local quality... documentation; and Quality control. 200.89 Section 200.89 Education Regulations of the Offices of the Department...-interviewing; Eligibility documentation; and Quality control. (a) Allocation of funds under the MEP for fiscal...

  11. 17 CFR 200.30-1 - Delegation of authority to Director of Division of Corporation Finance.

    Science.gov (United States)

    2010-04-01

    ... Director of Division of Corporation Finance. 200.30-1 Section 200.30-1 Commodity and Securities Exchanges... Division of Corporation Finance. Pursuant to the provisions of Pub. L., No. 87-592, 76 Stat. 394 (15 U.S.C... otherwise, the following functions to the Director of the Division of Corporation Finance, to be performed...

  12. 30 CFR 243.200 - How do I demonstrate financial solvency?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I demonstrate financial solvency? 243.200 Section 243.200 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS REVENUE MANAGEMENT Financial Solvency...

  13. 24 CFR 1710.200 - Instructions for Statement of Record, Additional Information and Documentation.

    Science.gov (United States)

    2010-04-01

    ...-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (INTERSTATE LAND SALES... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Instructions for Statement of Record, Additional Information and Documentation. 1710.200 Section 1710.200 Housing and Urban Development...

  14. 24 CFR 200.950 - Building product standards and certification program for solar water heating system.

    Science.gov (United States)

    2010-04-01

    ... certification program for solar water heating system. 200.950 Section 200.950 Housing and Urban Development... solar water heating system. (a) Applicable standards. (1) All solar water heating systems shall be...) Document OG-300-93, Operating Guidelines and Minimum Standards for Certifying Solar Water Heating Systems...

  15. 30 CFR 715.200 - Interpretative rules related to general performance standards.

    Science.gov (United States)

    2010-07-01

    ... performance standards. 715.200 Section 715.200 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND... in part 715 of this chapter have been adopted by the Office of Surface Mining Reclamation and... Agriculture Forest Service published data based on soil series properties and behavior; or (iv) Results of...

  16. Revised Hydrogeology for the Suprabasalt Aquifer System, 200-West Area and Vicinity, Hanford Site, Washington

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Bruce A.; Bjornstad, Bruce N.; Schalla, Ronald; Webber, William D.

    2002-05-14

    The primary objective of this study was to refine the conceptual groundwater flow model for the 200-West Area and vicinity. This is the second of two reports that combine to cover the 200 Area Plateau, an area that holds the largest inventory of radionuclide and chemical waste on the Hanford Site.

  17. 29 CFR 2530.200b-7 - Day of service for employees in the maritime industry.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Day of service for employees in the maritime industry. 2530.200b-7 Section 2530.200b-7 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY... industry. (a) General rule. A day of service in the maritime industry which must, as a minimum, be counted...

  18. 34 CFR 200.1 - State responsibilities for developing challenging academic standards.

    Science.gov (United States)

    2010-07-01

    ... can validly document academic achievement. (ii)(A) The student's progress to date in response to... academic standards. 200.1 Section 200.1 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC...

  19. 20 CFR 200.9 - Selection of members of Actuarial Advisory Committee.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Selection of members of Actuarial Advisory Committee. 200.9 Section 200.9 Employees' Benefits RAILROAD RETIREMENT BOARD GENERAL ADMINISTRATION GENERAL... any organization formed jointly by the express companies, sleeping-car companies and carriers by...

  20. The Functions of MicroRNA-200 Family in Ovarian Cancer: Beyond Epithelial-Mesenchymal Transition

    Directory of Open Access Journals (Sweden)

    Pui-Wah Choi

    2017-06-01

    Full Text Available The majority of studies on microRNA-200 family members (miR-200s in human cancers are based on the premise that miR-200s maintain epithelial cell integrity by suppressing epithelial-mesenchymal transition (EMT through direct inhibition of mesenchymal transcription factors zinc finger E-box-binding homeobox 1/2 (ZEB1/ZEB2 and transforming growth factor-β (TGF-β, a potent inducer of EMT. Hence, downregulation of miR-200 in cancer cells promotes EMT and cancer metastasis. Yet, miR-200s are highly expressed in ovarian cancer, and ovarian cancer metastasizes primarily by dissemination within the pelvic cavity. In this review, we will refocus the epithelial property of ovarian cancer cells and the role of miR-200s in safeguarding this property, as well as the diverse roles of miR-200s in inclusion cyst formation, cancer cell growth, collective movement, angiogenesis, exosome-mediated cell communication, and chemoresponse. Taken together, miR-200s play a significant role in the initiation, progression and metastasis of ovarian cancer and may serve as diagnostic biomarkers and a target in therapeutic development.

  1. Development of a 200kW multi-fuel type PAFC power plant

    Energy Technology Data Exchange (ETDEWEB)

    Take, Tetsuo; Kuwata, Yutaka; Adachi, Masahito; Ogata, Tsutomu [NTT Integrated Information & Energy System Labs., Tokyo (Japan)

    1996-12-31

    Nippon Telegraph and Telephone Corporation (NFT) has been developing a 200 kW multi-fuel type PAFC power plant which can generate AC 200 kW of constant power by switching fuel from pipeline town gas to liquefied propane gas (LPG) and vice versa. This paper describes the outline of the demonstration test plant and test results of its fundamental characteristics.

  2. Functional Role of the microRNA-200 Family in Breast Morphogenesis and Neoplasia

    Directory of Open Access Journals (Sweden)

    Bylgja Hilmarsdottir

    2014-09-01

    Full Text Available Branching epithelial morphogenesis is closely linked to epithelial-to-mesenchymal transition (EMT, a process important in normal development and cancer progression. The miR-200 family regulates epithelial morphogenesis and EMT through a negative feedback loop with the ZEB1 and ZEB2 transcription factors. miR-200 inhibits expression of ZEB1/2 mRNA, which in turn can down-regulate the miR-200 family that further results in down-regulation of E-cadherin and induction of a mesenchymal phenotype. Recent studies show that the expression of miR-200 genes is high during late pregnancy and lactation, thereby indicating that these miRs are important for breast epithelial morphogenesis and differentiation. miR-200 genes have been studied intensively in relation to breast cancer progression and metastasis, where it has been shown that miR-200 members are down-regulated in basal-like breast cancer where the EMT phenotype is prominent. There is growing evidence that the miR-200 family is up-regulated in distal breast metastasis indicating that these miRs are important for colonization of metastatic breast cancer cells through induction of mesenchymal to epithelial transition. The dual role of miR-200 in primary and metastatic breast cancer is of interest for future therapeutic interventions, making it important to understand its role and interacting partners in more detail.

  3. 12 CFR 563b.200 - What actions may OTS take on my application?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What actions may OTS take on my application? 563b.200 Section 563b.200 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY... sale of shares, and demonstrate that the earnings multiple used is appropriate, including future...

  4. 12 CFR 19.200 - Effect of suspension, debarment or censure.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Effect of suspension, debarment or censure. 19.200 Section 19.200 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES OF... such individual's future representations may be subject to conditions designed to promote high...

  5. Resolved 200mu M images of nearby galaxies - evidence for an extended distribution of cold dust

    NARCIS (Netherlands)

    Valentijn, E; Alton, P.B.; Threwhella, M.; Davies, J.I.; Bianchi, S.; Gear, W.; Thronson, H.; Witt, A.

    1998-01-01

    We present resolved 200mu m images for 8 nearby galaxies observed with the Infrared Space Observatory (ISO). By comparing the 200mu m observations with IRAS 60mu m and 100mu m data, we find that cold dust becomes more dominant at larger radii. We infer a grain temperature of 18-21 K for this cold

  6. 50 CFR 665.200 - Hawaii bottomfish and seamount groundfish fisheries. [Reserved

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Hawaii bottomfish and seamount groundfish fisheries. 665.200 Section 665.200 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN...

  7. A Truncated form of CD200 (CD200S Expressed on Glioma Cells Prolonged Survival in a Rat Glioma Model by Induction of a Dendritic Cell-Like Phenotype in Tumor-Associated Macrophages

    Directory of Open Access Journals (Sweden)

    Kana Kobayashi

    2016-04-01

    Full Text Available CD200 induces immunosuppression in myeloid cells expressing its receptor CD200R, which may have consequences for tumor immunity. We found that human carcinoma tissues express not only full-length CD200 (CD200L but also its truncated form, CD200S. Although CD200S is reported to antagonize the immunosuppressive actions of CD200L, the role of CD200S in tumor immunity has never been investigated. We established rat C6 glioma cell lines that expressed either CD200L or CD200S; the original C6 cell line did not express CD200 molecules. The cell lines showed no significant differences in growth. Upon transplantation into the neonatal Wistar rat forebrain parenchyma, rats transplanted with C6-CD200S cells survived for a significantly longer period than those transplanted with the original C6 and C6-CD200L cells. The C6-CD200S tumors were smaller than the C6-CD200L or C6-original tumors, and many apoptotic cells were found in the tumor cell aggregates. Tumor-associated macrophages (TAMs in C6-CD200S tumors displayed dendritic cell (DC-like morphology with multiple processes and CD86 expression. Furthermore, CD3+, CD4+ or CD8+ cells were more frequently found in C6-CD200S tumors, and the expression of DC markers, granzyme, and perforin was increased in C6-CD200S tumors. Isolated TAMs from original C6 tumors were co-cultured with C6-CD200S cells and showed increased expression of DC markers. These results suggest that CD200S activates TAMs to become DC-like antigen presenting cells, leading to the activation of CD8+ cytotoxic T lymphocytes, which induce apoptotic elimination of tumor cells. The findings on CD200S action may provide a novel therapeutic modality for the treatment of carcinomas.

  8. MicroRNA-200b is downregulated in colon cancer budding cells

    Science.gov (United States)

    Lindebjerg, Jan; Nielsen, Boye Schnack; Hansen, Torben Frøstrup; Sørensen, Flemming Brandt

    2017-01-01

    Background The microRNA-200 (miR-200) family acts as a major suppressor of epithelial-mesenchymal transition (EMT). Impaired miR-200 expression may lead to EMT initiation and eventually cancer dissemination. The presence of tumor budding cells (TBC) is associated with metastasis and poor prognosis, and molecular similarities to EMT indicate that these cells may reflect ongoing EMT. The aim of this study was to investigate the expression of miR-200b in budding cells of colon cancer and the relationship with the EMT-markers E-cadherin, β-catenin and laminin-5γ2. Material & methods MiR-200b was investigated by in situ hybridization in 58 cases of stage II (n = 36) and III colon (n = 22) cancers with tumor budding. Expression of E-cadherin, β-catenin and laminin-5γ2 was examined by immunohistochemistry. A multiplex fluorescence assay combining miR-200b with cytokeratin and laminin-5γ2 was employed on a subset of 16 samples. Results MiR-200b was downregulated in the TBC at the invasive front of 41 out of 58 (71%) cases. The decline was present in both mismatch satellite stable and instable adenocarcinomas. The majority of cases also showed loss of membranous E-cadherin and increased nuclear β-catenin in the TBC, while laminin-5γ2 expression was upregulated at the invasive front and in the tumor buds of approximately half the adenocarcinomas. However, the miR-200b decline was not statistically associated with the expression of any of the EMT-markers. The miR-200b decline was also documented by multiplex fluorescence. Fourteen out of fifteen cases showed a decrease in miR-200b expression in the majority of the TBC, but no obvious relationship between miR-200b and laminin-5γ2 expression was observed. Conclusion: The findings support the assumption of a miR-200b related downregulation in colon cancer budding cells. Whether miR-200b expression may be of clinical significance awaits further studies. PMID:28552992

  9. Constitutive Retinal CD200 Expression Regulates Resident Microglia and Activation State of Inflammatory Cells during Experimental Autoimmune Uveoretinitis

    OpenAIRE

    Broderick, Cathryn; Hoek, Robert M.; Forrester, John V.; Liversidge, Janet; Sedgwick, Jonathon D.; Dick, Andrew D

    2002-01-01

    Recent evidence supports the notion that tissue OX2 (CD200) constitutively provides down-regulatory signals to myeloid-lineage cells via CD200-receptor (CD200R). Thus, mice lacking CD200 (CD200−/−) show increased susceptibility to and accelerated onset of tissue-specific autoimmunity. In the retina there is extensive expression of CD200 on neurons and retinal vascular endothelium. We show here that retinal microglia in CD200−/− mice display normal morphology, but unlike microglia from wild-ty...

  10. BAF200 is required for heart morphogenesis and coronary artery development.

    Directory of Open Access Journals (Sweden)

    Lingjuan He

    Full Text Available ATP-dependent SWI/SNF chromatin remodeling complexes utilize ATP hydrolysis to non-covalently change nucleosome-DNA interactions and are essential in stem cell development, organogenesis, and tumorigenesis. Biochemical studies show that SWI/SNF in mammalian cells can be divided into two subcomplexes BAF and PBAF based on the subunit composition. ARID2 or BAF200 has been defined as an intrinsic subunit of PBAF complex. However, the function of BAF200 in vivo is not clear. To dissect the possible role of BAF200 in regulating embryogenesis and organ development, we generated BAF200 mutant mice and found they were embryonic lethal. BAF200 mutant embryos exhibited multiple cardiac defects including thin myocardium, ventricular septum defect, common atrioventricular valve, and double outlet right ventricle around E14.5. Moreover, we also detected reduced intramyocardial coronary arteries in BAF200 mutants, suggesting that BAF200 is required for proper migration and differentiation of subepicardial venous cells into arterial endothelial cells. Our work revealed that PBAF complex plays a critical role in heart morphogenesis and coronary artery angiogenesis.

  11. MicroRNA-200b Expression in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy.

    Science.gov (United States)

    Gomaa, Amir Ramadan; Elsayed, Eman Tayae; Moftah, Reham Fadl

    2017-01-01

    The role of microRNA (miRNA)-200b in the pathogenesis of proliferative diabetic retinopathy (PDR) has been studied in diabetic animal models. The aim of this study was to assess miRNA-200b expression in the vitreous of patients with PDR and to determine its correlation with vascular endothelial growth factor (VEGF), one of the pathogenic mechanisms in PDR. Quantitative reverse transcription polymerase chain reaction was used to measure miRNA-200b expression in the vitreous from 29 eyes with PDR and 30 eyes with idiopathic macular holes (IMH; control group). Vitreous VEGF was measured using an enzyme-linked immunosorbent assay. miRNA-200b expression was about 5-fold increased in the vitreous samples from eyes with PDR compared with the controls (p ≤ 0.001). Vitreous VEGF expression was also significantly higher in the PDR group than in the IMH group (p ≤ 0.001), but no significant correlation was found between miRNA-200b and VEGF. Both miRNA-200b and VEGF are increased in the vitreous of patients with PDR but in a noncorrelated pattern. miRNA-200b may be involved in the pathogenesis of PDR but through VEGF-independent mechanisms. Further studies are needed to identify the miRNA-200b-targeted genes involved in the pathogenesis of PDR and to examine the potential role of miRNA-200b as a target for PDR treatment. © 2017 S. Karger AG, Basel.

  12. Exploring the Behaviour of Long Gamma-Ray Bursts with Intrinsic Afterglow Correlations: log L200s−α>200s

    Directory of Open Access Journals (Sweden)

    Samantha R. Oates

    2017-01-01

    Full Text Available In these proceedings, we summarise the exploration so far of the relationship between the afterglow luminosity (measured at rest frame 200s; log L 200 s and average afterglow decay rate (measured from rest frame 200s onwards, α > 200 s of long duration Gamma-ray Bursts (GRBs, first reported in the optical/UV light curves of GRB afterglows. We show that this correlation is also present in the X-ray afterglows of GRBs as observed by Swift-XRT. We explore how the parameters of the correlation observed in both the X-ray and optical/UV light curves relate to each other and the prompt emission phase and whether these correlations are consistent with predictions of the standard afterglow model. We find that the observed correlations are consistent with a common underlying physical mechanism producing GRBs and their afterglows regardless of the detailed temporal behaviour. However, a basic afterglow model has difficulty explaining all the observed correlations. This leads us to briefly discuss alternative more complex models.

  13. A damage model of Zr {alpha} under cyclic loading at 200 degree Celsius; Modelisation de l`endommagement du Zr {alpha} sous chargement cyclique a 200 deg C

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, C.; Drubay, B. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. de Mecanique et de Technologie; Cailletaud, G. [Ecole Nationale Superieure des Mines, 75 - Paris (France); Mottot, M. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Direction des Technologies Avancees

    1994-12-31

    A damage model for anticipating zirconium {alpha} test-piece rupture under cyclic solicitations at 200 degree Celsius is presented. The article is divided into three parts : an experimental approach, the damage model presentation and the application of this model. (O.L.). 10 refs., 7 figs., 4 tabs.

  14. EFFICACY OF IMIDACLOPRID (CONFIDOR 200 SL AGAINST APHIDS INFESTING WHEAT CROP

    Directory of Open Access Journals (Sweden)

    N Joshi

    2010-02-01

    Full Text Available Imidacloprid (Confidor 200 SL was evaluated either alone or with a fungicide (Tilt 0.01% against wheat aphids. There were seven different treatments, including an untreated control. All the treatments were replicated three times in a similar field environment. Population of wheat aphids was recorded on randomly selected five plants in each plot at different intervals, both before and after the spraying. Confidor 200 SL @ 400 ml/ha treatment was found most effective against wheat aphids. However, mixing of Confidor 200 SL @ 100 ml/ha with Tilt @ 0.01 %, was found significantly least effective for wheat aphids control.

  15. 200 Areas Remedial Investigation/Feasibility Study ImplementationPlan - Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    A. J. Knepp.

    1999-04-19

    The 200 Areas Remedial Investigation/Feasibility Study Implementation Plan - Environmental Restoration Program (Implementation Plan) addresses approximately 700 soil waste sites (and associated structures suchas pipelines) resulting from the discharge of liquids and solids fromprocessing facilities to the ground (e.g., ponds, ditches, cribs,burial grounds) in the 200 Areas and assigned to the Environmental Restoration Program. The Implementation Plan outlines the frameworkfor implementing assessment activities in the 200 Areas to ensure consistency in documentation, level of characterization, and decisionmaking. The Implementation Plan also consolidates background information and other typical work plan materials, to serve as a single referenceable source for this type of information.

  16. June 200

    African Journals Online (AJOL)

    School Distance from No. of Percentage prevalence Intensity of infection. Barombi Kotto pupils (egg count/ 10 m1 urine). Proteinuria Haematuria Schistosomiasis Mean i SD Range Median. P.S. Barombi Kotto 0 km 180 65.5 76.0 73.9 567 i 865 0 - 3486 166. Govt School New Town Barombi East, 5 km 21 23.8 23.8 14.3 1 i 3 ...

  17. The VASIMR[registered trademark] VF-200-1 ISS Experiment as a Laboratory for Astrophysics

    Science.gov (United States)

    Glover Tim W.; Squire, Jared P.; Longmier, Benjamin; Cassady, Leonard; Ilin, Andrew; Carter, Mark; Olsen, Chris S.; McCaskill, Greg; Diaz, Franklin Chang; Girimaji, Sharath; hide

    2010-01-01

    The VASIMR[R] Flight Experiment (VF-200-1) will be tested in space aboard the International Space Station (ISS) in about four years. It will consist of two 100 kW parallel plasma engines with opposite magnetic dipoles, resulting in a near zero-torque magnetic system. Electrical energy will come from ISS at low power level, be stored in batteries and used to fire the engine at 200 kW. The VF-200-1 project will provide a unique opportunity on the ISS National Laboratory for astrophysicists and space physicists to study the dynamic evolution of an expanding and reconnecting plasma loop. Here, we review the status of the project and discuss our current plans for computational modeling and in situ observation of a dynamic plasma loop on an experimental platform in low-Earth orbit. The VF-200-1 project is still in the early stages of development and we welcome new collaborators.

  18. USGS Small-scale Dataset - Color Hawaii Shaded Relief - 200-Meter Resolution 200512 GeoTIFF

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The NED is...

  19. Inhibition of CD200R1 expression by C/EBP beta in reactive microglial cells

    Directory of Open Access Journals (Sweden)

    Dentesano Guido

    2012-07-01

    Full Text Available Abstract Background In physiological conditions, it is postulated that neurons control microglial reactivity through a series of inhibitory mechanisms, involving either cell contact-dependent, soluble-factor-dependent or neurotransmitter-associated pathways. In the current study, we focus on CD200R1, a microglial receptor involved in one of these cell contact-dependent mechanisms. CD200R1 activation by its ligand, CD200 (mainly expressed by neurons in the central nervous system,is postulated to inhibit the pro-inflammatory phenotype of microglial cells, while alterations in CD200-CD200R1 signalling potentiate this phenotype. Little is known about the regulation of CD200R1 expression in microglia or possible alterations in the presence of pro-inflammatory stimuli. Methods Murine primary microglial cultures, mixed glial cultures from wild-type and CCAAT/enhancer binding protein β (C/EBPβ-deficient mice, and the BV2 murine cell line overexpressing C/EBPβ were used to study the involvement of C/EBPβ transcription factor in the regulation of CD200R1 expression in response to a proinflammatory stimulus (lipopolysaccharide (LPS. Binding of C/EBPβ to the CD200R1 promoter was determined by quantitative chromatin immunoprecipitation (qChIP. The involvement of histone deacetylase 1 in the control of CD200R1 expression by C/EBPβ was also determined by co-immunoprecipitation and qChIP. Results LPS treatment induced a decrease in CD200R1 mRNA and protein expression in microglial cells, an effect that was not observed in the absence of C/EBPβ. C/EBPβ overexpression in BV2 cells resulted in a decrease in basal CD200R1 mRNA and protein expression. In addition, C/EBPβ binding to the CD200R1 promoter was observed in LPS-treated but not in control glial cells, and also in control BV2 cells overexpressing C/EBPβ. Finally, we observed that histone deacetylase 1 co-immunoprecipitated with C/EBPβ and showed binding to a C/EBPβ consensus sequence of the CD

  20. 34 CFR 200.80 - Migrant Education Even Start Program definition.

    Science.gov (United States)

    2010-07-01

    ... AND SECONDARY EDUCATION, DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Even Start Family Literacy Program § 200.80 Migrant Education Even Start Program definition...

  1. The COP1 E3-ligase interacts with FIP200, a key regulator of mammalian autophagy

    Directory of Open Access Journals (Sweden)

    Kobayashi Saori

    2013-01-01

    Full Text Available Abstract Background The ubiquitin ligase COP1, COnstitutively Photomorphogenic 1, functions in many biological responses in mammalian cells, but its downstream pathway remains unclear. Results Here, we identified FIP200, a key regulator of mammalian autophagy, as a novel COP1-interacting protein by yeast two-hybrid screening. The interaction was confirmed by a GST-pulldown assay. Split-GFP analysis revealed that interaction between COP1 and FIP200 predominantly occurred in the cytoplasm and was enhanced in cells treated with UV irradiation. Different forms of FIP200 protein were expressed in cultured mammalian cells, and ectopic expression of COP1 reduced one of such forms. Conclusions These data suggest that COP1 modulates FIP200-associated activities, which may contribute to a variety of cellular functions that COP1 is involved in.

  2. Haridusministeerium kingib koolilõpetajatele 200 000 eest šokolaadi / Mirko Ojakivi

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2006-01-01

    Haridus- ja Teadusministeerium kingib keskkoolide, gümnaasiumide ja kutsekoolide lõpetajatele 200 000 krooni eest Kalevi erikujundusega šokolaadi. Seda otsust kritiseerib endine haridusminister Tõnis Lukas

  3. Investigating the Role of FIP200 in Mammary Carcinogenesis Using a Transgenic Mouse Model

    National Research Council Canada - National Science Library

    Nagy, Tamas

    2006-01-01

    .... Since our original plan was to inhibit the activities of FAK indirectly using its inhibitor, FIP200, I decided to directly delete FAK in the mammary epithelium of mice employing the Cre-loxP method...

  4. Cold test of cylindrical open resonator for 42 GHz, 200 kW gyrotron

    Indian Academy of Sciences (India)

    ),. Pilani 333 031, India ... design and fabrication of the specific gyrotron cavity. Keywords. Gyrotron; resonator; electric ... Recently in India, a program of design and development of the 42 GHz, 200 kW gyrotron has been initiated for the Indian.

  5. 17 CFR 200.306 - Requests for amendment or correction of records.

    Science.gov (United States)

    2010-04-01

    ... COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Regulations Pertaining to the..., additional information will be required. Verification of the individual's identity as set forth in § 200.303...

  6. Color Alaska Shaded Relief ? 200-Meter Resolution, Albers projection - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The NED is...

  7. USGS Small-scale Dataset - Color Alaska Shaded Relief - 200-Meter Resolution 200512 GeoTIFF

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Alaska shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Alaska at a resolution of 200 meters. The NED is...

  8. Color Hawaii Shaded Relief ? 200-Meter Resolution, Albers projection - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The color Hawaii shaded relief data were derived from National Elevation Dataset (NED) data, and show the terrain of Hawaii at a resolution of 200 meters. The NED is...

  9. Challenges in assessing personality of individuals with Gender Dysphoria with the SWAP-200.

    Science.gov (United States)

    Lingiardi, V; Giovanardi, G

    2017-07-01

    Personality assessment can be useful to better understand the complexity of transgender and transsexual people. In particular, the Shedler Westen Assessment Procedure-200 (SWAP-200) is a measure that provides an accurate dimensional evaluation of personality. When assessing gender non-conforming people, however, clinicians can encounter some difficulties in giving appropriate ratings to all the items. A brief guide to the use of SWAP-200 with transgender patients is provided, taking into account three areas of psychological functioning: identity, relationships and sexuality. The authors review, one by one, the SWAP-200 items related to these areas, and, relying on their clinical experience and on scientific literature on Gender Dysphoria, they propose recommendations for making personality diagnoses meaningful. This paper facilitates a better clinical understanding of transgender people, and help clinicians to be more knowledgeable in the assessment of this heterogeneous population.

  10. Summary of radioactive solid waste received in the 200 Areas during calendar year 1995

    Energy Technology Data Exchange (ETDEWEB)

    Hladek, K.L.

    1996-06-06

    Westinghouse Hanford Company manages and operates the Hanford Site 200 Area radioactive solid waste storage and disposal facilities for the US Department of Energy, Richland Operations Office. These facilities include radioactive solid waste disposal sites and radioactive solid waste storage areas. This document summarizes the amount of radioactive materials that have been buried and stored in the 200 Area radioactive solid waste storage and disposal facilities since startup in 1944 through calendar year 1995. This report does not include backlog waste, solid radioactive wastes in storage or disposed of in other areas, or facilities such as the underground tank farms. Unless packaged within the scope of WHC-EP-0063, Hanford Site Solid Waste Acceptance Criteria, liquid waste data are not included in this document. This annual report provides a summary of the radioactive solid waste received in the both the 200-East and 200-West Areas during the calendar year 1995.

  11. 29 CFR 779.200 - Coverage expanded by 1961 and 1966 amendments.

    Science.gov (United States)

    2010-07-01

    ... Coverage Enterprise; the Business Unit § 779.200 Coverage expanded by 1961 and 1966 amendments. The 1961... employees in a particular business unit are covered by the Act. Prior to the 1961 amendments each employee's...

  12. EFFICACY OF IMIDACLOPRID (CONFIDOR 200 SL) AGAINST APHIDS INFESTING WHEAT CROP

    OpenAIRE

    Joshi, N.; Sharma, V.

    2009-01-01

    Imidacloprid (Confidor 200 SL) was evaluated either alone or with a fungicide (Tilt 0.01%) against wheat aphids. There were seven different treatments, including an untreated control. All the treatments were replicated three times in a similar field environment. Population of wheat aphids was recorded on randomly selected five plants in each plot at different intervals, both before and after the spraying. Confidor 200 SL @ 400 ml/ha treatment was found most effective against wheat aphids. How...

  13. Annex D-200 Area Interim Storage Area Final Safety Analysis Report [FSAR] [Section 1 & 2

    Energy Technology Data Exchange (ETDEWEB)

    CARRELL, R D

    2002-07-16

    The 200 Area Interim Storage Area (200 Area ISA) at the Hanford Site provides for the interim storage of non-defense reactor spent nuclear fuel (SNF) housed in aboveground dry cask storage systems. The 200 Area ISA is a relatively simple facility consisting of a boundary fence with gates, perimeter lighting, and concrete and gravel pads on which to place the dry storage casks. The fence supports safeguards and security and establishes a radiation protection buffer zone. The 200 Area ISA is nominally 200,000 ft{sup 2} and is located west of the Canister Storage Building (CSB). Interim storage at the 200 Area ISA is intended for a period of up to 40 years until the materials are shipped off-site to a disposal facility. This Final Safety Analysis Report (FSAR) does not address removal from storage or shipment from the 200 Area ISA. Three different SNF types contained in three different dry cask storage systems are to be stored at the 200 Area ISA, as follows: (1) Fast Flux Test Facility Fuel--Fifty-three interim storage casks (ISC), each holding a core component container (CCC), will be used to store the Fast Flux Test Facility (FFTF) SNF currently in the 400 Area. (2) Neutron Radiography Facility (NRF) TRIGA'--One Rad-Vault' container will store two DOT-6M3 containers and six NRF TRIGA casks currently stored in the 400 Area. (3) Commercial Light Water Reactor Fuel--Six International Standards Organization (ISO) containers, each holding a NAC-I cask4 with an inner commercial light water reactor (LWR) canister, will be used for commercial LWR SNF from the 300 Area. An aboveground dry cask storage location is necessary for the spent fuel because the current storage facilities are being shut down and deactivated. The spent fuel is being transferred to interim storage because there is no permanent repository storage currently available.

  14. MiR-200a inhibits epithelial-mesenchymal transition of pancreatic cancer stem cell.

    Science.gov (United States)

    Lu, Yuhua; Lu, Jingjing; Li, Xiaohong; Zhu, Hui; Fan, Xiangjun; Zhu, Shajun; Wang, Yao; Guo, Qingsong; Wang, Lei; Huang, Yan; Zhu, Mingyan; Wang, Zhiwei

    2014-02-12

    Pancreatic cancer is one of the most aggressive cancers, and the aggressiveness of pancreatic cancer is in part due to its intrinsic and extrinsic drug resistance characteristics, which are also associated with the acquisition of epithelial-to-mesenchymal transition (EMT). Increasing evidence suggests that EMT-type cells share many biological characteristics with cancer stem-like cells. And miR-200 has been identified as a powerful regulator of EMT. Cancer Stem Cells (CSCs) of human pancreatic cancer cell line PANC-1 were processed for CD24, CD44 and ESA multi-colorstaining, and sorted out on a BD FACS Aria II machine. RT-qPCR was performed using the miScript PCR Kit to assay the expression of miR-200 family. In order to find the role of miR-200a in the process of EMT, miR-200a mimic was transfected to CSCs. Pancreatic cancer cells with EMT phenotype displayed stem-like cell features characterized by the expression of cell surface markers CD24, CD44 and epithelial-specific antigen (ESA), which was associated with decreased expression of miR-200a. Moreover, overexpression of miR-200a was resulted in down-regulation of N-cadherin, ZEB1 and vimentin, but up-regulation of E-cadherin. In addition, miR-200a overexpression inhibited cell migration and invasion in CSCs. In our study, we found that miR-200a played an important role in linking the characteristics of cancer stem-like cells with EMT-like cell signatures in pancreatic cancer. Selective elimination of cancer stem-like cells by reversing the EMT phenotype to mesenchymal-to-epithelial transition (MET) phenotype using novel agents would be useful for prevention and/or treatment of pancreatic cancer.

  15. Depletion of CD200+ Hair Follicle Stem Cells in Human Prematurely Gray Hair Follicles

    OpenAIRE

    Mohanty, Sujata; Kumar, Anil; Dhawan, Jyoti; Sharma, Vinod K; Gupta, Somesh

    2013-01-01

    Introduction: Melanocyte stem cells (MelSCs) are known to be depleted in gray hair follicles. Hair follicle stem cells (HFSCs) are important for maintenance of stemness of MelSCs. Methods: We compared the proportion of CD200+ (Cluster of Differentiation 200 positive) stem cells in the outer root sheath cell suspension of gray and pigmented hair follicles of three patients with the premature graying of hair. In addition, explants culture for HFSCs was also carried out from gray and pigmented h...

  16. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  17. The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against anemia.

    Science.gov (United States)

    Miasnikova, Galina Y; Sergueeva, Adelina I; Nouraie, Mehdi; Niu, Xiaomei; Okhotin, Daniel J; Polyakova, Lydia A; Ganz, Tomas; Prchal, Josef T; Gordeuk, Victor R

    2011-09-01

    The germ-line loss-of-function VHL(R200W) mutation is common in Chuvashia, Russia and occurs in other parts of the world. VHL(R200W) homozygotes have elevated hypoxia inducible factor (HIF)-1 and HIF-2 levels, increased hemoglobin concentration, propensity to thrombosis and early mortality. Because the mutation persists from an ancient origin, we hypothesized that there is a heterozygote advantage. Thirty-four VHL(R200W) heterozygotes and 44 controls over 35 years of age from Chuvashia, Russia were studied. Anemia was defined as hemoglobin less than 130 g/L in men and less than 120 g/L in women. Mild anemia was present in 15% of VHL(R200W) heterozygotes and 34% of controls without a mutated VHL allele. By multivariate logistic regression, the odds of anemia were reduced an estimated 5.6-fold in the VHL(R200W) heterozygotes compared to controls (95% confidence interval 1.4-22.7; P=0.017). In conclusion, heterozygosity for VHL(R200W) may provide protection from anemia; such protection could explain the persistence of this mutation.

  18. Design and Initial Characterization of the SC-200 Proteomics Standard Mixture

    Science.gov (United States)

    Bauman, Andrew; Higdon, Roger; Rapson, Sean; Loiue, Brenton; Hogan, Jason; Stacy, Robin; Napuli, Alberto; Guo, Wenjin; van Voorhis, Wesley; Roach, Jared; Lu, Vincent; Landorf, Elizabeth; Stewart, Elizabeth; Kolker, Natali; Collart, Frank; Myler, Peter; van Belle, Gerald

    2011-01-01

    Abstract High-throughput (HTP) proteomics studies generate large amounts of data. Interpretation of these data requires effective approaches to distinguish noise from biological signal, particularly as instrument and computational capacity increase and studies become more complex. Resolving this issue requires validated and reproducible methods and models, which in turn requires complex experimental and computational standards. The absence of appropriate standards and data sets for validating experimental and computational workflows hinders the development of HTP proteomics methods. Most protein standards are simple mixtures of proteins or peptides, or undercharacterized reference standards in which the identity and concentration of the constituent proteins is unknown. The Seattle Children's 200 (SC-200) proposed proteomics standard mixture is the next step toward developing realistic, fully characterized HTP proteomics standards. The SC-200 exhibits a unique modular design to extend its functionality, and consists of 200 proteins of known identities and molar concentrations from 6 microbial genomes, distributed into 10 molar concentration tiers spanning a 1,000-fold range. We describe the SC-200's design, potential uses, and initial characterization. We identified 84% of SC-200 proteins with an LTQ-Orbitrap and 65% with an LTQ-Velos (false discovery rate = 1% for both). There were obvious trends in success rate, sequence coverage, and spectral counts with protein concentration; however, protein identification, sequence coverage, and spectral counts vary greatly within concentration levels. PMID:21250827

  19. Reparación de fracturas de suelo orbitario con hidroxiapatita HAP-200 Repair of orbital floor fractures with HAP-200 hydroxyapatite

    Directory of Open Access Journals (Sweden)

    Juan Carlos Quintana Díaz

    2005-12-01

    Full Text Available Se realizó un estudio clínico y radiográfico pre y posoperatorio en 4 pacientes con fracturas del suelo orbitario reparadas con hidroxiapatita HAP-200. En ninguno de los pacientes se encontró reacción adversa ante este material implantalógico y sí muy buena tolerancia y adaptabilidad, lo que nos reafirmó su alta biocompatibilidad, por lo que lo recomendamos en el tratamiento de esta afección.A pre- and postoperative clinical and X-ray study was conducted in 4 patients with orbital floor fractures repaired with HAP-200hydroxyapatite. . No adverse reaction to this material was observed in any of the patients, who showed a good tolerance and adaptability that confirmed its high biocompatibility and make it recommendable for treating this affection.

  20. FEASIBILITY STUDY REPORT FOR THE 200-ZP-1 GROUNDWATER OPERABLE UNIT

    Energy Technology Data Exchange (ETDEWEB)

    BYRNES ME

    2008-07-18

    The Hanford Site, managed by the U.S. Department of Energy (DOE), encompasses approximately 1,517 km{sup 2} (586 mi{sup 2}) in the Columbia Basin of south-central Washington State. In 1989, the U.S. Environmental Protection Agency (EPA) placed the 100, 200, 300, and 1100 Areas of the Hanford Site on the 40 Code of Federal Regulations (CFR) 300, 'National Oil and Hazardous Substances Pollution Contingency Plan' National Contingency Plan [NCPD], Appendix B, 'National Priorities List' (NPL), pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The 200 Areas NPL sites consist of the 200 West and 200 East Areas (Figure 1-1). The 200 Areas contain waste management facilities, inactive irradiated fuel reprocessing facilities, and the 200 North Area (formerly used for interim storage and staging of irradiated fuel). Several waste sites in the 600 Area, located near the 200 Areas, also are included in the 200 Areas NPL site. The 200 Areas NPL site is in a region referred to as the 'Central Plateau' and consists of approximately 700 waste sites, excluding sites assigned to the tank farm waste management areas (WMAs). The 200-ZP-1 Groundwater Operable Unit (OU) consists of the groundwater located under the northern portion of the 200 West Area. Waste sources that contributed to the 200-ZP-1 OU included cribs and trenches that received liquid and/or solid waste in the past from the Z Plant and T Plant aggregate areas, WMA-T, WMA-TX/TY, and the State-Approved Land Disposal Site (SALDS). This feasibility study (FS) for the 200-ZP-1 Groundwater OU was prepared in accordance with the requirements of CERCLA decision documents. These decision documents are part of the Administrative Record for the selection of remedial actions for each waste site and present the selected remedial actions that are chosen in accordance with CERCLA, as amended by the Superfund Amendments and Reauthorization Act of 1986

  1. Phase 1 remedial investigation report for 200-BP-1 operable unit. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    The US Department of Energy (DOE) Hanford Site, in Washington State is organized into numerically designated operational areas including the 100, 200, 300, 400, 600, and 1100 Areas. The US Environmental Protection Agency (EPA), in November 1989 included the 200 Areas of the Hanford Site on the National Priority List (NPL) under the Comprehensive Environmental Response, Compensation and Liability Act of 1980 (CERCLA). Inclusion on the NPL initiated the remedial investigation (RD process for the 200-BP-1 operable unit. These efforts are being addressed through the Hanford Federal Facility Agreement and Consent Order (Ecology et al. 1989) which was negotiated and approved by the DOE, the EPA, and the State of Washington Department of Ecology (Ecology) in May 1989. This agreement, known as the Tri-Party Agreement, governs all CERCLA efforts at Hanford. In March of 1990, the Department of Energy, Richland Operations (DOE-RL) issued a Remedial Investigation/Feasibility Study (RI/FS) work plan (DOE-RL 1990a) for the 200-BP-1 operable unit. The work plan initiated the first phase of site characterization activities associated with the 200-BP-1 operable unit. The purpose of the 200-BP-1 operable unit RI is to gather and develop the necessary information to adequately understand the risks to human health and the environment posed by the site and to support the development and analysis of remedial alternatives during the FS. The RI analysis will, in turn, be used by Tri-Party Agreement signatories to make a risk-management-based selection of remedies for the releases of hazardous substances that have occurred from the 200-BP-1 operable unit.

  2. Pregnancy Outcomes in Women with 1-Hour Glucose Challenge Test ≥ 200 mg/dL.

    Science.gov (United States)

    Ankumah, Nana-Ama; Tita, Alan T N; Biggio, Joseph R; Harper, Lorie M

    2016-04-01

    Many protocols diagnose gestational diabetes mellitus (GDM) solely on a 1-hour glucose challenge test (GCT) ≥ 200 mg/dL. However, pregnancy outcomes in these women compared with women diagnosed with a 3-hour glucose tolerance test (GTT) has not been adequately evaluated. We hypothesize that a 1-hour GCT ≥ 200 mg/dL is associated with worse pregnancy outcomes as compared with a GCT 135 to 199 mg/dL with positive GTT. A retrospective cohort of singleton pregnancies complicated by GDM. Maternal outcomes included A2DM, preeclampsia, primary cesarean, and failed trial of labor after cesarean. Perinatal outcomes were large/small for gestational age, shoulder dystocia, and birth injury. Groups were compared with t-test and chi-square test, and logistic regression to adjust for confounders. A total of 602 women diagnosed with GDM by 1-hour GCT 135 to 199 mg/dL and confirmatory 3-hour GTT (< 200 group) and 225 women diagnosed with 1-hour GCT ≥ 200 alone (≥ 200) were included. The ≥ 200 group had a higher incidence of preeclampsia (16.4 vs. 10.6%) and shoulder dystocia (3.1 vs. 1.0%). Adjusted odds ratio and 95% confidence interval were 1.80 (1.10-2.94) and 5.10 (1.25-20.76), respectively. Preeclampsia and shoulder dystocia are more frequent in women with GCT ≥ 200 mg/dL than those with a positive GTT following a GCT of 135 to 199 mg/dL. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  3. Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression.

    Science.gov (United States)

    Gordeuk, Victor R; Miasnikova, Galina Y; Sergueeva, Adelina I; Niu, Xiaomei; Nouraie, Mehdi; Okhotin, Daniel J; Polyakova, Lydia A; Ammosova, Tatiana; Nekhai, Sergei; Ganz, Tomas; Prchal, Josef T

    2011-11-10

    Hypoxia is known to reduce the expression of hepcidin, the master regulator of iron metabolism. However, it is not clear whether this response is primarily related to increased erythropoiesis driven by hypoxically stimulated erythropoietin or to a more direct effect of hypoxia on hepcidin expression. The germline loss-of-function VHL(R200W) mutation is common in Chuvashia, Russia, and also occurs elsewhere. VHL(R200W) homozygotes have elevated hypoxia-inducible factor 1α (HIF-1α) and HIF-2α levels, increased red cell mass, propensity to thrombosis, and early mortality. Ninety VHL(R200W) homozygotes and 52 controls with normal VHL alleles from Chuvashia, Russia, were studied under basal circumstances. In univariate analyses, serum hepcidin concentration was correlated positively with serum ferritin concentration and negatively with homozygosity for VHL(R200W). After adjustment for serum erythropoietin and ferritin concentrations by multiple linear regression, the geometric mean (95% confidence interval of mean) hepcidin concentration was 8.1 (6.3-10.5) ng/mL in VHL(R200W) homozygotes versus 26.9 (18.6-38.0) ng/mL in controls (P < .001). In contrast, a significant independent relationship of serum erythropoietin, hemoglobin, or RBC count with hepcidin was not observed. In conclusion, up-regulation of the hypoxic response leads to decreased expression of hepcidin that may be independent of increased erythropoietin levels and increased RBC counts.

  4. MiR-200c suppresses the migration of retinoblastoma cells by reversing epithelial mesenchymal transition

    Directory of Open Access Journals (Sweden)

    Xiao-Lei Shao

    2017-08-01

    Full Text Available AIM: To analyze the relationship between clinical features and epithelial mesenchymal transition (EMT in retinoblastoma (RB, further to investigate whether miR-200c regulates the EMT and migration of RB cells. METHODS: Expression of EMT-related markers and tumor-related factors were detected by immuno-histochemistry analysis in RB tissue from 29 cases. Correlations between their expression and clinical characteristics were analyzed. The regulation effects of miR-200c on EMT-related markers, tumor-related factors were observed in mRNA level and protein level by real-time polymerase chain reaction (PCR and Western blot, respectively, in Y79 and Weri-rb1 cells. Its effects on migration force of these RB cell lines were also detected with Transwell test. RESULTS: Lower expression of E-cadherin was present in the cases with malignant prognosis. MiR-200c promoted the expression of E-cadherin and decreased the expression of Vimentin and N-cadherin in Y79 and Weri-rb1 cells. Migration force of RB cells could be inhibited by miR-200c. CONCLUSION: EMT might be associated with bad prognosis in RB. MiR-200c suppresses the migration of retinoblastomatous cells by reverse EMT.

  5. CD200-expressing human basal cell carcinoma cells initiate tumor growth.

    Science.gov (United States)

    Colmont, Chantal S; Benketah, Antisar; Reed, Simon H; Hawk, Nga V; Telford, William G; Ohyama, Manabu; Udey, Mark C; Yee, Carole L; Vogel, Jonathan C; Patel, Girish K

    2013-01-22

    Smoothened antagonists directly target the genetic basis of human basal cell carcinoma (BCC), the most common of all cancers. These drugs inhibit BCC growth, but they are not curative. Although BCC cells are monomorphic, immunofluorescence microscopy reveals a complex hierarchical pattern of growth with inward differentiation along hair follicle lineages. Most BCC cells express the transcription factor KLF4 and are committed to terminal differentiation. A small CD200(+) CD45(-) BCC subpopulation that represents 1.63 ± 1.11% of all BCC cells resides in small clusters at the tumor periphery. By using reproducible in vivo xenograft growth assays, we determined that tumor initiating cell frequencies approximate one per 1.5 million unsorted BCC cells. The CD200(+) CD45(-) BCC subpopulation recreated BCC tumor growth in vivo with typical histological architecture and expression of sonic hedgehog-regulated genes. Reproducible in vivo BCC growth was achieved with as few as 10,000 CD200(+) CD45(-) cells, representing ~1,500-fold enrichment. CD200(-) CD45(-) BCC cells were unable to form tumors. These findings establish a platform to study the effects of Smoothened antagonists on BCC tumor initiating cell and also suggest that currently available anti-CD200 therapy be considered, either as monotherapy or an adjunct to Smoothened antagonists, in the treatment of inoperable BCC.

  6. Depletion of CD200+ hair follicle stem cells in human prematurely gray hair follicles

    Directory of Open Access Journals (Sweden)

    Sujata Mohanty

    2013-01-01

    Full Text Available Introduction: Melanocyte stem cells (MelSCs are known to be depleted in gray hair follicles. Hair follicle stem cells (HFSCs are important for maintenance of stemness of MelSCs. Methods: We compared the proportion of CD200+ (Cluster of Differentiation 200 positive stem cells in the outer root sheath cell suspension of gray and pigmented hair follicles of three patients with the premature graying of hair. In addition, explants culture for HFSCs was also carried out from gray and pigmented hair follicles. Cultured HFSCs were also differentiated into melanocytes. Results: The mean ± SD CD200+ HFSCs population were 9.4 ± 1.4% and 3.5 ± 0.5% for pigmented and gray hair follicles, respectively ( P = 0.002. In explants culture, the growth of HFSCs from the gray hair follicle stopped at around day 20-22, whereas the growth of the cells from the pigmented follicle continued. Conclusion: CD200+ HFSCs are depleted in prematurely gray hair in the humans. CD200+ hair follicle stem cell yield is poorer in gray hair explant culture than pigmented hair explant culture.

  7. Depletion of CD200+ Hair Follicle Stem Cells in Human Prematurely Gray Hair Follicles.

    Science.gov (United States)

    Mohanty, Sujata; Kumar, Anil; Dhawan, Jyoti; Sharma, Vinod K; Gupta, Somesh

    2013-04-01

    Melanocyte stem cells (MelSCs) are known to be depleted in gray hair follicles. Hair follicle stem cells (HFSCs) are important for maintenance of stemness of MelSCs. We compared the proportion of CD200+ (Cluster of Differentiation 200 positive) stem cells in the outer root sheath cell suspension of gray and pigmented hair follicles of three patients with the premature graying of hair. In addition, explants culture for HFSCs was also carried out from gray and pigmented hair follicles. Cultured HFSCs were also differentiated into melanocytes. The mean ± SD CD200+ HFSCs population were 9.4 ± 1.4% and 3.5 ± 0.5% for pigmented and gray hair follicles, respectively (P = 0.002). In explants culture, the growth of HFSCs from the gray hair follicle stopped at around day 20-22, whereas the growth of the cells from the pigmented follicle continued. CD200+ HFSCs are depleted in prematurely gray hair in the humans. CD200+ hair follicle stem cell yield is poorer in gray hair explant culture than pigmented hair explant culture.

  8. 41 CFR 102-73.200 - What types of special purpose space may the Department of the Interior lease?

    Science.gov (United States)

    2010-07-01

    ... purpose space may the Department of the Interior lease? 102-73.200 Section 102-73.200 Public Contracts and... § 102-73.200 What types of special purpose space may the Department of the Interior lease? The Department of the Interior is delegated authority to lease the following types of special purpose space: (a...

  9. 17 CFR 200.13b - Director of the Office of Public Affairs, Policy Evaluation, and Research.

    Science.gov (United States)

    2010-04-01

    ... Public Affairs, Policy Evaluation, and Research. 200.13b Section 200.13b Commodity and Securities... Organization and Program Management General Organization § 200.13b Director of the Office of Public Affairs, Policy Evaluation, and Research. The Director of the Office of Public Affairs, Policy Evaluation, and...

  10. Increased Expression of CD200 on Circulating CD11b+ Monocytes in Patients with Neovascular Age-related Macular Degeneration

    DEFF Research Database (Denmark)

    Singh, Amardeep; Falk, Mads K; Hviid, Thomas V F

    2013-01-01

    OBJECTIVE: Dysregulation of retinal microglial activity has been implicated in the pathogenesis of neovascular age-related macular degeneration. Microglia activity can be regulated through the membrane protein CD200 and its corresponding receptor, the CD200 receptor (CD200R). Because both the lig...

  11. 34 CFR 200.100 - Reservation of funds for school improvement, State administration, and the State academic...

    Science.gov (United States)

    2010-07-01

    ... administration, and the State academic achievement awards program. 200.100 Section 200.100 Education Regulations..., DEPARTMENT OF EDUCATION TITLE I-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED General Provisions § 200.100 Reservation of funds for school improvement, State administration, and the State academic...

  12. 34 CFR 200.85 - Responsibilities of SEAs and operating agencies for improving services to migratory children.

    Science.gov (United States)

    2010-07-01

    ... improving services to migratory children. 200.85 Section 200.85 Education Regulations of the Offices of the...-IMPROVING THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Migrant Education Program § 200.85 Responsibilities of SEAs and operating agencies for improving services to migratory children. While the specific...

  13. 10 CFR 35.200 - Use of unsealed byproduct material for imaging and localization studies for which a written...

    Science.gov (United States)

    2010-01-01

    ... Required § 35.200 Use of unsealed byproduct material for imaging and localization studies for which a... 10 Energy 1 2010-01-01 2010-01-01 false Use of unsealed byproduct material for imaging and localization studies for which a written directive is not required. 35.200 Section 35.200 Energy NUCLEAR...

  14. JAERI 200 kV Electron Gun with an NEA-GaAs Photocathode

    CERN Document Server

    Nishitani, Tomohiro; Kikuzawa, Nobuhiro; John Minehara, Eisuke; Nagai, Ryoji; Nishimori, Nobuyuki; Sawamura, Masaru; Yamauchi, T

    2004-01-01

    The GaAs photocathode with negative electron affinity surface (NEA-GaAs) has been expected to be low emittance (<0.5 πmm・mrad) electron beam source. In order to generate low emittance electron beam required from ERL-FEL, we have started the developmental program of a 200keV electron gun with the NEA-GaAs photocathode for the first time in JAERI. An NEA surface has the problem that lifetime is limited by gun vacuum condition and by ion back bombardment between anode- and cathode-electrode. In order to long an NEA surface lifetime, the JAERI 200keV electron gun system consists of a 200kV DC-gun chamber on extreme high vacuum condition and an NEA activation chamber with load-lock system.

  15. Current exposure of 200 pregnant Danish women to phthalates, parabens and phenols

    DEFF Research Database (Denmark)

    Tefre de Renzy-Martin, Katrine; Frederiksen, Hanne; Christensen, Jeppe Hagstrup

    2014-01-01

    Many phthalates, parabens and phenols are suspected to have endocrine disrupting properties in humans. They are found in consumer products, including food wrapping, cosmetics and building materials. The foetus is vulnerable and exposure to these chemicals is of particular concern for pregnant women....... We therefore studied current exposure to several commonly used phthalates, parabens and phenols in 200 healthy, pregnant Danish women. A total of 200 spot urine samples were collected between weeks 8-30 of pregnancy and analysed for 10 phenols, 7 parabens and 16 phthalate metabolites by LC......-MS/MS. The 33 analytes represent 26 non-persistent compounds. The majority of analytes were present in urine from most women. Thus, in 174 of the 200 women, metabolites of more than 13 (>50%) of 26 compounds were detected simultaneously. The number of compounds detected per woman (either as the parent compound...

  16. EFFECTS OF SWIMMING TECHIQUES ON FINAL RESULT IN 200M INDIVIDUAL MEDLEY

    Directory of Open Access Journals (Sweden)

    Goran Dimitrić

    2013-07-01

    Full Text Available Swimming results are permanently improving. Results in individual medley disciplines are also improving. Individual medley disciplines are consist of all four swimming techiques. Results in these disciplines depende amongother things, on the swimming quality in all techniques. In 200m individual medley, each techinque implies 50m swimming, in following order: butterfly, backstroke, breast stroke and free style. The aim of this paper is to determine individual affect of each swimming technique on 200m individual medley final result. Reasearh was based on the achieved times of 30 male and 30 female swimmers who participated in 200m individual medley qualifications on European chanpionship - Szczecin 2011, Poland. According to adequate statistical methods and analysis of results, certain conclusions will be derived

  17. Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer

    Directory of Open Access Journals (Sweden)

    Kan Casina WS

    2012-12-01

    Full Text Available Abstract Background There is a critical need for improved diagnostic markers for high grade serous epithelial ovarian cancer (SEOC. MicroRNAs are stable in the circulation and may have utility as biomarkers of malignancy. We investigated whether levels of serum microRNA could discriminate women with high-grade SEOC from age matched healthy volunteers. Methods To identify microRNA of interest, microRNA expression profiling was performed on 4 SEOC cell lines and normal human ovarian surface epithelial cells. Total RNA was extracted from 500 μL aliquots of serum collected from patients with SEOC (n = 28 and age-matched healthy donors (n = 28. Serum microRNA levels were assessed by quantitative RT-PCR following preamplification. Results microRNA (miR-182, miR-200a, miR-200b and miR-200c were highly overexpressed in the SEOC cell lines relative to normal human ovarian surface epithelial cells and were assessed in RNA extracted from serum as candidate biomarkers. miR-103, miR-92a and miR -638 had relatively invariant expression across all ovarian cell lines, and with small-nucleolar C/D box 48 (RNU48 were assessed in RNA extracted from serum as candidate endogenous normalizers. No correlation between serum levels and age were observed (age range 30-79 years for any of these microRNA or RNU48. Individually, miR-200a, miR-200b and miR-200c normalized to serum volume and miR-103 were significantly higher in serum of the SEOC cohort (P  Conclusions We identified serum microRNAs able to discriminate patients with high grade SEOC from age-matched healthy controls. The addition of these microRNAs to current testing regimes may improve diagnosis for women with SEOC.

  18. Development of the CCP-200 mathematical model for Syzran CHPP using the Thermolib software package

    Science.gov (United States)

    Usov, S. V.; Kudinov, A. A.

    2016-04-01

    Simplified cycle diagram of the CCP-200 power generating unit of Syzran CHPP containing two gas turbines PG6111FA with generators, two steam recovery boilers KUP-110/15-8.0/0.7-540/200, and one steam turbine Siemens SST-600 (one-cylinder with two variable heat extraction units of 60/75 MW in heatextraction and condensing modes, accordingly) with S-GEN5-100 generators was presented. Results of experimental guarantee tests of the CCP-200 steam-gas unit are given. Brief description of the Thermolib application for the MatLab Simulink software package is given. Basic equations used in Thermolib for modeling thermo-technical processes are given. Mathematical models of gas-turbine plant, heat-recovery steam generator, steam turbine and integrated plant for power generating unit CCP-200 of Syzran CHPP were developed with the help of MatLab Simulink and Thermolib. The simulation technique at different ambient temperature values was used in order to get characteristics of the developed mathematical model. Graphic comparison of some characteristics of the CCP-200 simulation model (gas temperature behind gas turbine, gas turbine and combined cycle plant capacity, high and low pressure steam consumption and feed water consumption for high and low pressure economizers) with actual characteristics of the steam-gas unit received at experimental (field) guarantee tests at different ambient temperature are shown. It is shown that the chosen degrees of complexity, characteristics of the CCP-200 simulation model, developed by Thermolib, adequately correspond to the actual characteristics of the steam-gas unit received at experimental (field) guarantee tests; this allows considering the developed mathematical model as adequate and acceptable it for further work.

  19. The immunoglobulin superfamily member CD200R identifies cells involved in type 2 immune responses

    DEFF Research Database (Denmark)

    Blom, Lars H; Martel, Britta C; Larsen, Lau F

    2017-01-01

    , were stimulated (14-16h) with peanut extract to detect peanut-specific CD4(+) CD154(+) T-cells. Biopsies were obtained for transcriptomic analysis from healthy controls and patients with extrinsic or intrinsic atopic dermatitis and psoriasis. RESULTS: Expression analysis of >300 surface proteins...... cells. Finally, transcriptomic analysis revealed up-regulation of CD200R in lesional skin from subjects with an extrinsic atopic dermatitis phenotype compared to healthy skin. CONCLUSION: These results indicate that CD200R expression strongly correlates with Th2 pathology; though, the mechanism...

  20. Activity of the European high heat flux test facility: FE200

    Energy Technology Data Exchange (ETDEWEB)

    Bobin-Vastra, I. [AREVA Centre Technique de Framatome, FE200, Porte Magenta BP181, 71200 Le Creusot Cedex (France) and EFDA Close Support Unit, Boltzmannstr. 2, D-85748 Garching (Germany)]. E-mail: isabelle.bobinvastra@framatome-anp.com; Escourbiac, F. [Association Euratom-CEA, CEA/DSM/DRFC, CEA/Cadarache, F-13108 Saint Paul lez Durance (France)]. E-mail: escourbi@drfc.cad.cea.fr; Merola, M. [EFDA Close Support Unit, Boltzmannstr. 2, D-85748 Garching (Germany)]. E-mail: mario.merola@tech.efda.org; Lorenzetto, P. [EFDA Close Support Unit, Boltzmannstr. 2, D-85748 Garching (Germany)]. E-mail: lorenzp@tech.efda.org

    2005-11-15

    FE200 is an electron beam (EB) 200 kW test facility resulting since 1991 from partnership between Framatome Technical Centre in Le Creusot (France) and Tore Supra team in CEA Cadarache (France). It is dedicated to high heat flux testing of small and medium-sized plasma facing components. The performed tests are thermal fatigue tests (100,000 since 1992), critical heat fluxes, disruptions, glancing incidence tests on materials such as Cu-Al25 and CuCrZr alloys, carbon fibre composite (CFC) or tungsten (W). The thermal fatigue behaviour of some primary first wall (PFW), hypervapotron and divertor components is described.

  1. Always on the starting line: ELCAT 200 - the new-generation electric vehicle

    Energy Technology Data Exchange (ETDEWEB)

    Baeckstroem, K.; Leisio, C. [ed.

    1997-11-01

    The Elcat 200 electric van can always be left charging. With most other electric van models, the situation is different. They run the risk of overcharging, which prevents continual `refuelling` of their batteries and thus considerably reduces the performance of the vehicles. The Elcat electric vehicle project has so far manufactured over 160 electric vans. Of these, the Elcat Cityvan accounts for 130, and the state-of-the-art Elcat 200 just over 30. The greatest single Elcat user is Finland Post, with 50 electric vehicles. Fifty Elcats have been sold abroad, most of them to Sweden

  2. Reduced expression of miR-200 family members contributes to antiestrogen resistance in LY2 human breast cancer cells.

    Directory of Open Access Journals (Sweden)

    Tissa T Manavalan

    Full Text Available INTRODUCTION: The role of miRNAs in acquired endocrine-resistant breast cancer is not fully understood. One hallmark of tumor progression is epithelial-to-mesenchymal transition (EMT, characterized by a loss of cell adhesion resulting from reduced E-cadherin and increased cell mobility. miR-200 family members regulate EMT by suppressing expression of transcriptional repressors ZEB1/2. Previously we reported that the expression of miR-200a, miR-200b, and miR-200c was lower in LY2 endocrine-resistant, mesenchymal breast cancer cells compared to parental, endocrine sensitive, epithelial MCF-7 breast cancer cells. Here we investigated the regulation of miR-200 family members and their role in endocrine-sensitivity in breast cancer cells. RESULTS: miR-200 family expression was progressively reduced in a breast cancer cell line model of advancing endocrine/tamoxifen (TAM resistance. Concomitant with miR-200 decrease, there was an increase in ZEB1 mRNA expression. Overexpression of miR-200b or miR-200c in LY2 cells altered cell morphology to a more epithelial appearance and inhibited cell migration. Further, miR-200b and miR-200c overexpression sensitized LY2 cells to growth inhibition by estrogen receptor (ER antagonists TAM and fulvestrant. Knockdown of ZEB1 in LY2 cells recapitulated the effect of miR-200b and miR-200c overexpression resulting in inhibition of LY2 cell proliferation by TAM and fulvestrant, but not the aromatase inhibitor exemestane. Demethylating agent 5-aza-2'-deoxycytidine (5-aza-dC in combination with histone deacetylase inhibitor trichostatin A (TSA increased miR-200b and miR-200c in LY2 cells. Concomitant with the increase in miR-200b and miR-200c, ZEB1 expression was decreased and cells appeared more epithelial in morphology and were sensitized to TAM and fulvestrant inhibition. Likewise, knockdown of ZEB1 increased antiestrogen sensitivity of LY2 cells resulting in inhibition of cell proliferation. CONCLUSIONS: Our data

  3. Relationship Between Patient SWAP-200 Personality Characteristics and Therapist-Rated Therapeutic Alliance Early in Treatment.

    Science.gov (United States)

    Smith, Scott W; Levy, Saryn R; Hilsenroth, Mark J; Fiori, Katherine; Bornstein, Robert F

    2016-06-01

    In the present study, we assess the extent to which patient personality features and prototypes are associated with early treatment therapist-rated alliance. The study sample consisted of 94 patients receiving psychodynamic psychotherapy at an outpatient clinic. Clinicians completed the Working Alliance Inventory (J Couns Psychol 36:223-233; Psychother Res 9:405-423) to assess their views of early alliance and the Shedler-Westen Assessment Procedure 200 (SWAP-200; Assessment 5:333-353, Am J Psychiatry 161:1350-1365, 1743-1754; Am J Psychiatry 156:258-272, 273-285) to assess patient personality. The SWAP-200 Narcissistic Clinical Prototype, Dysphoric Q-Factor, and Dysphoric/High-Functioning Neurotic Q-Subfactor significantly correlated with early therapist-rated alliance. Correlations that trended toward significance were also found. Also identified were specific SWAP-200 items that were found to relate to high early therapist-rated alliance scores. These results demonstrate some relationship, albeit small, between patient personality characteristics and therapists' views of the alliance that may serve to further a conceptual understanding of the alliance, specific personality syndromes, and the associated impact on the therapeutic interaction.

  4. Study of the hadronic $\\gamma\\gamma$ interactions at $\\sqrt{s}$ = 200 GeV

    CERN Document Server

    Alderweireld, T; Verdier, P

    2000-01-01

    A comparison between real data and Monte Carlo is presented, based on a data sample corresponding to the 84.3 pb-1 recorded by the DELPHI detector in 1999, at centre-of-mass energy of 200 GeV. Two hadronic gamma gamma generators have been used for this present analysis, TWOGAM 2.04 and PYTHIA 6.143.

  5. Radioactive liquid wastes discharged to ground in the 200 Areas during 1978

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, J. D.; Poremba, B. E.

    1979-03-26

    This document is issued quarterly for the purpose of summarizing the radioactive liquid wastes that have been discharged to the ground in the 200 Areas. In addition to data for 1978, cumulative data since plant startup are presented. Also, in this document is a listing of decayed activity to the various plant sites.

  6. 34 CFR 200.49 - SEA responsibilities for school improvement, corrective action, and restructuring.

    Science.gov (United States)

    2010-07-01

    ...-achieving schools to meet the progress goals in the school improvement plans under § 200.41. (c) Technical... 34 Education 1 2010-07-01 2010-07-01 false SEA responsibilities for school improvement, corrective... THE ACADEMIC ACHIEVEMENT OF THE DISADVANTAGED Improving Basic Programs Operated by Local Educational...

  7. 24 CFR 200.77 - Lead-based paint poisoning prevention.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Lead-based paint poisoning... Programs; and Continuing Eligibility Requirements for Existing Projects Property Requirements § 200.77 Lead-based paint poisoning prevention. Requirements set forth in 24 CFR part 35 apply to these programs. ...

  8. 46 CFR 170.200 - Estimated lightweight vertical center of gravity.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Estimated lightweight vertical center of gravity. 170... Centers of Gravity § 170.200 Estimated lightweight vertical center of gravity. (a) Each tank vessel that... calculations required by §§ 170.170 and 172.065, the vertical center of gravity of a tank vessel in the...

  9. The Subaru Fauresmith 200km Challenge: Looking a Gift-Horse in ...

    African Journals Online (AJOL)

    This article describes an equestrian sport known as 'endurance riding.' It focuses on the Subaru Fauresmith 200km Challenge, which is held every year in the small southern Free State town of Fauresmith. Given the steadily growing profi le of the event, both locally and internationally, it is argued that the time is ripe for ...

  10. Rapidity Dependence of Net-protons at sqrt(s_NN) = 200 GeV

    OpenAIRE

    Christiansen, Peter; collaboration, for the BRAHMS

    2002-01-01

    The BRAHMS collaboration has measured inclusive proton and anti-proton spectra at several rapidities (0 < y < 3) for Au+Au collisions at sqrt(s_NN) = 200 GeV. Rapidity densities of protons, anti-protons, and net-protons [N(p)-N(p-bar)] are presented as a function of rapidity.

  11. Sigma*-mediated electronic relaxation in 200nm photoexcited ammonia and heteroaromatics

    Directory of Open Access Journals (Sweden)

    Evans N. L.

    2013-03-01

    Full Text Available Time–resolved photoelectron spectra of ammonia display combination bands of the umbrella and stretching modes associated with the N–H coordinate of σ* relaxation. Time–resolved photodissociation studies determine timescales <200fs. Similar σ* photochemistry is found in heteroaromatics

  12. Low-dose mifepristone 200 mg and vaginal misoprostol for abortion

    NARCIS (Netherlands)

    Schaff, EA; Eisinger, SH; Stadalius, LS; Franks, P; Gore, BZ; Poppema, S

    The objectives of this study were to determine the effectiveness, side effects, and acceptability of one-third the standard 600 mg dose of mifepristone (200 mg) to induce abortion. A prospective trial at seven sites enrolled women greater than or equal to 18 years, up to 8 weeks pregnant, and

  13. EPA Awards $200,000 to two Los Angeles Small Businesses to Develop Sustainable Green Technologies

    Science.gov (United States)

    LOS ANGELES - Today, the U.S. Environmental Protection Agency announced $200,000 to two Southern California companies located in Torrance and Northridge to develop sustainable technologies that address environmental issues. A total of $1.9 million was awa

  14. [EFFECTIVE TREATMENT OF ACUTE GASTROENTERITIS IN INFANTS AND YOUNG CHILDREN WITH ORAL REHYDRATION SOLUTION (ORS 200)].

    Science.gov (United States)

    Manchev, B; Markov, D; Baikova, D

    2015-01-01

    In this paper are shown the basic rules of conduct for acute gastroenteritis in infancy. There are presented possibilities of solution HiPP (ORS 200), which in both its forms is appropriate and a good tool for oral rehydration in children of all ages with acute gastroenterokoitis.

  15. USGS Small-scale Dataset - Conterminous United States Land Cover 1992 - 200-Meter Resolution 200509 TIFF

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This map layer is GeoTIFF of 1992 land cover for the conterminous United States, at a resolution of 200 meters. The map layer was compiled by staff in the National...

  16. 50 CFR 216.200 - Specified activity and specified geographical region.

    Science.gov (United States)

    2010-10-01

    ... OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Taking of Marine Mammals Incidental to Construction and Operation of Offshore Oil and Gas Facilities in the U.S. Beaufort Sea § 216.200 Specified activity and...

  17. 17 CFR 200.24a - Director of the Office of Consumer Affairs.

    Science.gov (United States)

    2010-04-01

    ... COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General Organization § 200.24a Director of the Office of Consumer Affairs. The Director of the Office of... behavior, and the rights of investors in disputes they may have with individuals and entities regulated by...

  18. 28 CFR 44.200 - Unfair immigration-related employment practices.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Unfair immigration-related employment... IMMIGRATION-RELATED EMPLOYMENT PRACTICES Prohibited Practices § 44.200 Unfair immigration-related employment practices. (a)(1) General. It is unfair immigration-related employment practice for a person or other entity...

  19. Measurements on the SPS 200 MHz Travelling Wave Cavity towards an Impedance Model

    CERN Document Server

    Roggen, Toon; Caspers, Fritz; Vollinger, Christine; CERN. Geneva. ATS Department

    2016-01-01

    This note discusses the contribution of the SPS 200 MHz TWC (Travelling Wave Cavity) to the SPS longitudinal impedance model. The measurement method and setup is briefly explained and a comparison with simulations is discussed for both the fundamental pass band (FPB) as well as the Higher Order Modes (HOMs). In addition a number of improvements to the measurement setup are discussed.

  20. Material erosion and erosion products in disruption simulation experiments at the MK-200 UG facility

    Energy Technology Data Exchange (ETDEWEB)

    Arkhipov, N.I.; Bakhtin, V.P.; Kurkin, S.M.; Safronov, V.M.; Toporkov, D.A.; Vasenin, S.G.; Zhitlukhin, A.M.; Wuerz, H. E-mail: hermann.wurz@ihm.fzk.de

    2000-11-01

    Plasma/material interaction was studied in disruption simulation experiments at the plasma gun facility MK-200 UG. Graphite, tungsten and aluminium targets (beryllium-like material) were irradiated by intense plasma streams under heat fluxes typical for international thermonuclear experimental reactor (ITER) hard disruption. Materials were also exposed to radiation emitted by target plasma shields. Surface damage and erosion products were analysed.

  1. Respiratory outcomes following 100 mg/kg v. 200 mg/kg of poractant ...

    African Journals Online (AJOL)

    Background. e treatment guideline for the management of respiratory distress syndrome in the newborn unit at Auckland City Hospital (ACH), Auckland, New Zealand, was amended in July 2010. In keeping with current evidence, the initial dose of poractant alpha was increased from 100 mg/kg to 200 mg/kg. e outcomes of ...

  2. 17 CFR 200.30-7 - Delegation of authority to Secretary of the Commission.

    Science.gov (United States)

    2010-04-01

    ... Management General Organization § 200.30-7 Delegation of authority to Secretary of the Commission. Pursuant... designated from time to time by the Chairman of the Commission: (a) With respect to proceedings conducted....1101 of this chapter). (12) To issue orders instituting previously authorized administrative...

  3. OPTIMASI LAJU ALIR MASSA DALAM PURIFIKASI PENDINGIN RGTT200K UNTUK PROSES KONVERSI KARBONMONOKSIDA

    OpenAIRE

    Sumijanto Sumijanto; Sriyono Sriyono

    2016-01-01

    ABSTRAK OPTIMASI LAJU ALIR MASSA DALAM PURIFIKASI PENDINGIN RGTT200K UNTUK PROSES KONVERSI KARBONMONOKSIDA. Karbonmonoksida adalah spesi yang sulit dipisahkan dari helium pendingin reaktor karena mempunyai ukuran molekul relatif kecil sehingga diperlukan proses konversi menjadi karbondioksida. Laju konversi karbonmonoksida dalam sistem purifikasi dipengaruhi oleh beberapa parameter diantaranya konsentrasi, temperatur dan laju alir massa. Dalam penelitian ini dilakukan optimasi laju alir m...

  4. The PS200 catching trap: A new tool for ultralow-energy antiproton physics

    Energy Technology Data Exchange (ETDEWEB)

    Holzscheiter, M.H.; Dyer, P.L.; King, N.S.P.; Lizon, D.C.; Morgan, G.L.; Schecker, J.A. (Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)); Hoibraten, S. (University of Colorado, Boulder, Colorado 80309 (United States)); Lewis, R.A.; Otto, T. (Pennsylvania State University, Osmond Laboratory, University Park, Pennsylvania 16802 (United States)); Rochet, J. (CERN, Division PPE, CH 1211 Geneva (Switzerland)); Schauer, M.M. (Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States) Pennsylvania State University, Osmond Laboratory, University Park, Pennsylvania 16802 (United States))

    1994-10-01

    Approximately one million antiprotons have been trapped and electron cooled in the PS200 catching trap from a single fast extracted pulse from LEAR. The system is described in detail, different extraction schemes are discussed, and possible applications of this instrument to ultralow-energy atomic and nuclear physics with antiprotons are mentioned. [copyright] 1994 MAIK/Interperiodika

  5. The PS 200 catching trap: A new tool for ultra-low energy antiproton physics

    Energy Technology Data Exchange (ETDEWEB)

    Holzscheiter, M.H.; Dyer, P.L.; King, N.S.P.; Lizon, D.C.; Morgan, G.L.; Schauer, M.M.; Schecker, J.A. [Los Alamos National Lab., NM (United States); Hoibraten, S. [Colorado Univ., Boulder, CO (United States); Lewis, R.A.; Otto, T. [Pennsylvania State Univ., University Park, PA (United States). Noise Control Lab.; Rochet, J. [CERN, Div. PPE, Geneva (Switzerland)

    1994-04-01

    Approximately one million antiprotons have been trapped and electron cooled in the PS200 catching trap from a single fast extracted pulse from LEAR. The system is described in detail, different extraction schemes are discussed, and possible applications of this instrument to ultra-low energy atomic and nuclear physics with antiprotons are mentioned.

  6. Depth accuracy of the RealSense F200 : Low-cost 4D facial imaging

    NARCIS (Netherlands)

    Ten Harkel, Timen C.; Speksnijder, Caroline M.|info:eu-repo/dai/nl/304821535; Van Der Heijden, Ferdinand; Beurskens, Carien H.G.; Ingels, Koen J.A.O.; Maal, Thomas J J

    2017-01-01

    The RealSense F200 represents a new generation of economically viable 4-dimensional imaging (4D) systems for home use. However, its 3D geometric (depth) accuracy has not been clinically tested. Therefore, this study determined the depth accuracy of the RealSense, in a cohort of patients with a

  7. A Dictionary of Russian Idioms and Colloquialisms; 2,200 Expressions with Examples.

    Science.gov (United States)

    Jaszczun, Wasyl; Krynski, Szymon

    Some 2,200 expressions with illustrative sentences in Russian are contained in this dictionary intended for use as a reference work by students in intermediate and advanced Russian studies. The idioms or colloquialisms are rendered into English and are derived primarily from the classics of Russian literature. The dictionary covers phraseological…

  8. γ-Ray Emission from the Extreme Blazar 1ES 0229+200 J. Li, T ...

    Indian Academy of Sciences (India)

    pairs against Cosmic Microwave Background (CMB) photons to GeV energy bands (Dai et al. 2002; Neronov et al. 2011). In this paper, we consider a secondary γ-ray emission component to an extreme blazar 1ES 0229 + 200 for the multiwavelength radiation. Throughout this paper, we assume the Hub- ble constant H0 ...

  9. CHITINASE-B FROM SERRATIA-MARCESCENS-BJL200 IS EXPORTED TO THE PERIPLASM WITHOUT PROCESSING

    NARCIS (Netherlands)

    BRURBERG, MB; EIJSINK, VGH; HAANDRIKMAN, AJ; VENEMA, G; NES, IF

    A gene encoding a chitinase from Serratia marcescens BJL200 was cloned and expressed in Escherichia coli and S. marcescens. Nucleotide sequencing revealed an open reading frame encoding a 55.5 kDa protein of 499 amino acids without a typical signal peptide for export. The cellular localization of

  10. 21 CFR 172.820 - Polyethylene glycol (mean molecular weight 200-9,500).

    Science.gov (United States)

    2010-04-01

    ... dissolving known amounts of ethylene glycol and diethylene glycol in water. Suitable concentrations for... ethylene oxide and water with a mean molecular weight of 200 to 9,500. (2) It contains no more than 0.2 percent total by weight of ethylene and diethylene glycols when tested by the analytical methods...

  11. 40 CFR 246.200-5 - Recommended procedures: Methods of separation and collection.

    Science.gov (United States)

    2010-07-01

    ... Recommended Procedures § 246.200-5 Recommended procedures: Methods of separation and collection. (a) Systems... recommended system is the desk-top system because it is designed to maximize recovery of high value material.... The recommended desk-top system is carried out in the following manner: (1) Workers are to deposit...

  12. 21 CFR 200.15 - Definition of term “insulin.”

    Science.gov (United States)

    2010-04-01

    ...) DRUGS: GENERAL GENERAL General Provisions § 200.15 Definition of term “insulin.” For purposes of sections 801 and 802 of the act and this title, the term insulin means the active principle of the pancreas... the same as, or similar to, naturally occurring insulins in structure, use, and intended effect and...

  13. North versus South : Energy transition and energy intensity in Europe over 200 years

    NARCIS (Netherlands)

    Gales, Ben; Kander, Astrid; Malanima, Paolo; Rubio, Mar

    This article examines energy consumption in Sweden, Holland, Italy and Spain over 200 years, including both traditional and modern energy carriers. The analysis is based on totally new series of energy consumption including traditional carriers along with modern sources. Our main purposes are a

  14. 24 CFR 200.926a - Residential building code comparison items.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Residential building code... § 200.926a Residential building code comparison items. HUD will review each local and State code... doors and windows; (5) Unit smoke detectors; (6) Flame spread. (b) Light and ventilation. (1) Habitable...

  15. 40 CFR 80.200 - What gasoline is subject to the sulfur standards and requirements?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What gasoline is subject to the sulfur... (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Sulfur Gasoline Sulfur Standards § 80.200 What gasoline is subject to the sulfur standards and requirements? For the purpose of...

  16. Increasing N200 Potentials Via Visual Stimulus Depicting Humanoid Robot Behavior.

    Science.gov (United States)

    Li, Mengfan; Li, Wei; Zhou, Huihui

    2016-02-01

    Achieving recognizable visual event-related potentials plays an important role in improving the success rate in telepresence control of a humanoid robot via N200 or P300 potentials. The aim of this research is to intensively investigate ways to induce N200 potentials with obvious features by flashing robot images (images with meaningful information) and by flashing pictures containing only solid color squares (pictures with incomprehensible information). Comparative studies have shown that robot images evoke N200 potentials with recognizable negative peaks at approximately 260 ms in the frontal and central areas. The negative peak amplitudes increase, on average, from 1.2 μV, induced by flashing the squares, to 6.7 μV, induced by flashing the robot images. The data analyses support that the N200 potentials induced by the robot image stimuli exhibit recognizable features. Compared with the square stimuli, the robot image stimuli increase the average accuracy rate by 9.92%, from 83.33% to 93.25%, and the average information transfer rate by 24.56 bits/min, from 72.18 bits/min to 96.74 bits/min, in a single repetition. This finding implies that the robot images might provide the subjects with more information to understand the visual stimuli meanings and help them more effectively concentrate on their mental activities.

  17. Optical studies of hydrogen above 200 gigapascals - Evidence for metallization by band overlap

    Science.gov (United States)

    Mao, N. K.; Hemley, R. J.

    1989-01-01

    Direct optical observations of solid hydrogen to pressures in the 250-gigapascal range at 77 K are reported. Hydrogen samples appear nearly opaque at the maximum pressures. Measurements of absorption and Raman spectra provide evidence that electronic excitations in the visible region begin at about 200 gigapascals. The optical data are consistent with a band-overlap mechanism of metallization.

  18. Šveitsi firma plaanib investeerida Repo Vabrikutesse 200 miljonit krooni / Gerli Romanovitsh

    Index Scriptorium Estoniae

    Romanovitš, Gerli, 1977-

    2005-01-01

    Ilmunud ka: Severnoje Poberezhje 1. sept. lk 1,3. AS-i Repo Vabrikud omanik, Šveitsi investeerimisfirma Sorbes AG, kellele kuulus 51% ettevõtte aktsiatest, ostis SEB Eesti Ühispangalt ka ülejäänud aktsiad ning plaanib ainuomanikuna investeerida puitplaaditööstusesse 200 miljonit krooni

  19. Revised Hydrogeology for the Suprabasalt Aquifer System, 200-East Area and Vicinity, Hanford Site, Washington

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Bruce A.; Bjornstad, Bruce N.; Schalla, Ronald; Webber, William D.

    2000-04-20

    This study supports the Hanford Groundwater/Vadose integration project objectives to better understand the risk of groundwater contamination and potential risk to the public via groundwater flow paths. The primary objective of this study was to refine the conceptual groundwater flow model for the 200-East Area and vicinity.

  20. 24 CFR 200.945 - Supplementary specific requirements under the HUD building product standards and certification...

    Science.gov (United States)

    2010-04-01

    ... Accreditation Program of the U.S. Department of Commerce. (2) The administrator also shall review the quality... placed on each carpet every six feet not less than one foot from the edge. (c) Periodic tests and quality assurance inspection. Under the procedure set forth in § 200.935(d)(8), testing and inspection shall be...

  1. Soft photon production in central 200 GeV nucleon S-32+Au collisions

    NARCIS (Netherlands)

    Aggarwal, MM; Angelis, ALS; Antonenko, [No Value; Awes, TC; Badyal, SK; Barlag, C; Bhalla, KB; Bhatia, VS; Blume, C; Bock, D; Bohne, EM; Bucher, D; Buijs, A; Chattopadhyay, S; Claussen, A; Clewing, G; Das, AC; Devanand, [No Value; Donni, P; Durieux, E; Majumdar, MRD; Foka, P; Fokin, S; Ganti, MS; Garpman, S; Geurts, F; Ghosh, TK; Glasow, R; Gupta, SK; Gustafsson, H.A.; Gutbrod, HH; Hartig, M; Holker, G; Ippolitov, M; Izycki, M; Kachroo, S; Kalechofsky, H; Kamermans, R; Kampert, KH; Karadjev, K; Kolb, BW; Kumar, [No Value; Langbein, [No Value; Langheinrich, J; Lebedev, A; Lohner, H; Lokanathan, S; Manko, [No Value; Martin, M; Mittra, IS; Mookerjee, S; Naef, H; Nayak, SK; Nikolaev, S; Nystrand, J; Obenshain, FE; Oskarsson, A; Otterlund, [No Value; Peitzmann, T; Plasil, F; Purschke, M; Raniwala, S; Rao, NK; Rosselet, L; Roters, B; Rubio, JM; Saini, S; Sambyal, SS; Santo, R; Siemiarczuk, T; Siemssen, R; Sinha, BC; Slegt, S; Soderstrom, K; Solomey, N; Sorensen, SP; Stefanek, G; Steinhaeuser, P; Stenlund, E; Ster, A; Stuken, D; Trivedi, MD; Twenhoefel, C; vanEijndhoven, N; vanHeeringen, E; Vinogradov, A; Viyogi, YP; Young, GR

    Inclusive photons of low transverse momenta have been measured in 200 GeV/nucleon S-32+Au collisions at the CERN SPS. Data were taken in the WA93 experiment using a small acceptance BGO detector with longitudinal segmentation. The results are compared to WA80 measurements for the same system and

  2. Azimuthal anisotropy in S+Au reactions at 200 A GeV

    NARCIS (Netherlands)

    Aggarwal, MM; Angelis, ALS; Antonenko, [No Value; Awes, TC; Badyal, SK; Barlag, C; Bhalla, KB; Bhatia, VS; Blume, C; Bock, D; Bohne, EM; Bucher, D; Buijs, A; Chattopadhyay, S; Claussen, A; Clewing, G; Das, AC; Devanand, [No Value; Donni, P; Durieux, E; Majumdar, MRD; Foka, P; Fokin, S; Ganti, MS; Garpman, S; Geurts, F; Ghosh, TK; Glasow, R; Gupta, SK; Gustafsson, H.A.; Gutbrod, HH; Hartig, M; Holker, G; Ippolitov, M; Izycki, M; Kachroo, S; Kalechofsky, H; Kamermans, R; Kampert, KH; Karadjev, K; Kolb, BW; Langbein, [No Value; Langheinrich, J; Lebedev, A; Löhner, Herbert; Loknathan, S; Manko, [No Value; Martin, M; Mittra, IS; Mookerjee, S; Naef, H; Nayak, SK; Nayak, TK; Nikolaev, S; Nystrand, J; Obenshain, FE; Oskarsson, A; Otterlund, [No Value; Peitzmann, T; Plasil, F; Purschke, M; Raniwala, S; Rao, NK; Rosselet, L; Roters, B; Rubio, JM; Saini, S; Sambyal, S; Santo, R; Siemiarczuk, T; Siemssen, RH; Sinha, BC; Slegt, S; Soderstrom, K; Solomey, N; Sorensen, SP; Stefanek, G; Steinhaeuser, P; Stenlund, E; Ster, A; Stuken, D; Trivedi, MD; Twenhoefel, C; VanEijndhoven, N; VanHeeringen, WH; Vinogradov, A; Viyogi, YP; Young, GR

    1997-01-01

    Azimuthal correlations of photons produced at mid-rapidity in 200 A GeV S + Au collisions have been studied using a preshower photon multiplicity detector in the WA93 experiment. The Fourier expansion method has been employed to estimate the event plane via the anisotropy of the event as a function

  3. Experimental f″ of As at 170, 200, 250 and 300 K from the Bijvoet ...

    Indian Academy of Sciences (India)

    Unknown

    Experimental f″ of As at 170, 200, 250 and 300 K from the Bijvoet pairs of GaAs. G RAJA SUDHA, K VIMALA DEVI, D ARTHI, S PRASANNA SUBRAMANIAN,. N SRINIVASAN* and R SARAVANAN†. Department of Physics, Thiagarajar College, Madurai 625 009, India. †The Madura College, Madurai 625 011, India.

  4. 17 CFR 200.42 - Disposition of business by seriatim Commission consideration.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Disposition of business by... EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Disposition of Commission Business § 200.42 Disposition of business by seriatim Commission consideration. (a) Whenever the...

  5. 17 CFR 200.40 - Joint disposition of business by Commission meeting.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Joint disposition of business... EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Disposition of Commission Business § 200.40 Joint disposition of business by Commission meeting. Any meeting of the...

  6. 17 CFR 200.43 - Disposition of business by exercise of authority delegated to individual Commissioner.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Disposition of business by... Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Disposition of Commission Business § 200.43 Disposition of business by exercise of authority delegated to...

  7. Purification of lysyl oxidase from piglet skin by selective interaction with Sephacryl S-200.

    OpenAIRE

    Shackleton, D R; Hulmes, D J

    1990-01-01

    A method is described for the purification of piglet skin lysyl oxidase from a crude urea extract by two simple chromatographic procedures. The method relies on the selective interaction between Sephacryl S-200 and lysyl oxidase that occurs in the absence of urea and in conditions of low ionic strength.

  8. 17 CFR 200.30-5 - Delegation of authority to Director of Division of Investment Management.

    Science.gov (United States)

    2010-04-01

    ... that are principally engaged in the development or exploitation of inventions, technological... of the Commission pursuant to sections 5318A(a)(4), 5318A(e)(2) and 5318(h)(2) of the Bank Secrecy....263, and §§ 230.651-230.703(T) of this chapter as that delegated to each Regional Director in § 200.30...

  9. 16 CFR 20.0 - Scope and purpose of the guides.

    Science.gov (United States)

    2010-01-01

    ... REBUILT, RECONDITIONED AND OTHER USED AUTOMOBILE PARTS INDUSTRY § 20.0 Scope and purpose of the guides... used parts designed for use in automobiles, trucks, motorcycles, tractors, or similar self-propelled vehicles whether or not such parts or assemblies have been reconstructed in any way (hereinafter “industry...

  10. 34 CFR 200.31 - Opportunity to review school-level data.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Opportunity to review school-level data. 200.31 Section... Opportunity to review school-level data. (a) Before identifying a school for school improvement, corrective action, or restructuring, an LEA must provide the school with an opportunity to review the school-level...

  11. Oral two-generation reproduction toxicity study with NM-200 synthetic amorphous silica in Wistar rats

    NARCIS (Netherlands)

    Wolterbeek, A.; Oosterwijk, T.; Schneider, S.; Landsiedel, R.; Groot, D. de; Ee, R. van; Wouters, M.; Sandt, H. van de

    2015-01-01

    Synthetic amorphous silica (SAS) like NM-200 is used in a wide variety of technological applications and consumer products. Although SAS has been widely investigated the available reproductive toxicity studies are old and do not cover all requirements of current OECD Guidelines. As part of a

  12. The borderline personality organization in a dimensional perspective: the TCI and SWAP-200 in comparison.

    Science.gov (United States)

    Amianto, F; Laguzzi, S; Sobrero, C; Marzola, E; Abbate Daga, G; Fassino, S

    2012-12-01

    The categorical assessment of personality disorders, in particular of the borderline personality disorder is being debated by most authors. This study focuses on the structural organization of personality, namely on Kernberg's borderline personality organization (BPO). It aims to explore the dimensional personality assessment and to test the convergence on this construct of two dimensional instruments: the Temperament and Character Inventory (TCI) and the Shedler-Westen Assessment Procedure (SWAP-200). BPO was assessed with the Temperament and Character Inventory (TCI) and the Shedler-Westen Assessment Procedure (SWAP-200). Thirty-four BPO subjects were recruited in the study. TCI profiles of BPO subjects were compared with 34 non-BPO matched controls. TCI and SWAP-200 profiles were correlated with each other and with clinical data. BPO subjects showed higher harm avoidance and lower self-directedness (TCI). The SWAP-200 evidenced a schizotypal configuration (categorical classification) and histrionic and schizoid traits (Q-sort classification). The instruments displayed limited correlation. Instead they both extensively correlated with clinical history of BPO subjects. Implications for BPO assessment and its relationship with mental disorders are discussed. The knowledge of the BPO dimensional characteristics will improve clinical management and therapeutic strategies for BPO patients. Moreover the comparison of two dimensional instruments on the construct of BPO may shed a light on their strengths and weaknesses.

  13. Aspen overstory recruitment in northern Yellowstone National Park during the last 200 years

    Science.gov (United States)

    Eric J. Larsen; William J. Ripple

    2001-01-01

    Using a monograph provided by Warren (1926) and two sets of aspen increment cores collected in 1997 and 1998, we analyzed aspen overstory recruitment in Yellowstone National Park (YNP) over the past 200 years. We found that successful aspen overstory recruitment occurred on the northern range of YNP from the middle to late 1700s until the 1920s, after which it...

  14. Step Frequency and Step Length of 200-m Sprint in Able-bodied and Amputee Sprinters.

    Science.gov (United States)

    Hobara, H; Sano, Y; Kobayashi, Y; Heldoorn, T A; Mochimaru, M

    2016-02-01

    The goal of this study was to examine the hypothesis that the difference in the 200-m sprint performance of amputee and able-bodied sprinters is due to a shorter step length rather than a lower step frequency. Men's elite-level 200-m races with a total of 16 able-bodied, 13 unilateral transtibial, 5 bilateral transtibial, and 16 unilateral transfemoral amputee sprinters were analyzed from publicly available internet broadcasts. For each run, the average forward velocity, step frequency, and step length over the entire 200-m distance were analyzed for each sprinter. The average forward velocity of able-bodied sprinters was faster than that of the other 3 groups, but there was no significant difference in average step frequency between able-bodied and transtibial amputee sprinters. However, the average step length of able-bodied sprinters was significantly longer than that of the transtibial amputee sprinters. In contrast, the step frequency and step length of transfemoral amputees were significantly lower and shorter than those of the other 3 groups. These results suggest that the differences in 200-m sprint performance between able-bodied and amputee sprinters are dependent on amputation level. © Georg Thieme Verlag KG Stuttgart · New York.

  15. 19 CFR 200.735-114 - Employees required to submit statements.

    Science.gov (United States)

    2010-04-01

    ...-114 Section 200.735-114 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION EMPLOYEE... such positions, shall include the listing in the chapter of the Commission's Policy Manual pertaining... research activities where the decision to be made or action to be taken could have an economic impact on...

  16. Motion Planning and Dynamic Control of the Nomad 200 Mobile Robot in a Laboratory Environment.

    Science.gov (United States)

    1996-06-01

    Motion planning and control of a Nomad 200 mobile robot are studied in this thesis. The objective is to develop a motion planning and control...potential field algorithm is then combined with Dubin’s algorithm to incorporate orientation into motion planning . The combined algorithm is able to avoid

  17. Yeast Interacting Proteins Database: YER071C, YLR200W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available bait as prey (0) YLR200W YKE2 Subunit of the heterohexameric Gim/prefoldin protein complex involved in the...name YKE2 Prey description Subunit of the heterohexameric Gim/prefoldin protein complex involved in the

  18. 24 CFR 200.926 - Minimum property standards for one and two family dwellings.

    Science.gov (United States)

    2010-04-01

    ... units in a structure where the units are located side-by-side in town house fashion. Section 200.926d(c... submitted under this section must be submitted by the time the lender or other interested party applies for... local code has not been changed since the date the code or changes thereto were submitted to the...

  19. Catastrophe modelling: deriving the 1-in-200 year mortality shock for ...

    African Journals Online (AJOL)

    This paper investigates catastrophe risk for South African life insurers by considering the additional deaths that could arise from a 1-in-200 year mortality shock. Existing South African academic research on catastrophic risk has mostly focused on property losses and the resulting impact on property insurance companies.

  20. 20 CFR 200.5 - Protection of privacy of records maintained on individuals.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Protection of privacy of records maintained... ADMINISTRATION GENERAL ADMINISTRATION § 200.5 Protection of privacy of records maintained on individuals. (a... compliance with the Privacy Act of 1974 (Pub. L. 93-579). These regulations apply to all record systems...

  1. 38 CFR Appendix B to Part 200 - The Action Requiring an Environmental Assessment

    Science.gov (United States)

    2010-07-01

    ... Environmental Assessment B Appendix B to Part 200 Pensions, Bonuses, and Veterans' Relief ARMED FORCES...—The Action Requiring an Environmental Assessment The following actions are not considered to be major... and would require the preparation of an Environmental Assessment (EA): B.1Construction on previously...

  2. 29 CFR 786.200 - Enforcement policy concerning performance of nonexempt work.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Enforcement policy concerning performance of nonexempt work... MISCELLANEOUS EXEMPTIONS Taxicab Operators § 786.200 Enforcement policy concerning performance of nonexempt work... Standards Act will be deemed applicable even though some nonexempt work (that is, work of a nature other...

  3. 2-PROTON CORRELATIONS IN THE TARGET FRAGMENTATION REGION OF NUCLEAR COLLISIONS AT 200-A-GEV

    NARCIS (Netherlands)

    AWES, TC; BARLAG, C; BERGER, F; BLOOMER, MA; BLUME, C; BOCK, D; BOCK, R; BOHNE, EM; BUCHER, D; CLAUSSEN, A; CLEWING, G; DRAGON, L; EKLUND, A; GARPMAN, S; GLASOW, R; GUTBROD, HH; HOLKER, G; IDH, J; JACOBS, P; KAMPERT, KH; KOLB, BW; LOHNER, H; LUND, [No Value; OBENSHAIN, FE; OSKARSSON, A; OTTERLUND, [No Value; PEITZMANN, T; PLASIL, F; POSKANZER, AM; PURSCHKE, M; ROTERS, B; SAINI, S; SANTO, R; SCHMIDT, HR; SORENSEN, SP; STEFFENS, K; STEINHAEUSER, P; STENLUND, E; STUKEN, D; YOUNG, GR

    Correlations between protons are studied in the target fragmentation region of reactions of protons and O-16 with C, Cu, Ag, Au and of S-32 With Al and Au at 200 A GeV. The emitted protons were measured with the Plastic Ball detector in the WA80 experiment at the CERN SPS. The comparison of the

  4. OPTIMASI LAJU ALIR MASSA DALAM PURIFIKASI PENDINGIN RGTT200K UNTUK PROSES KONVERSI KARBONMONOKSIDA

    Directory of Open Access Journals (Sweden)

    Sumijanto Sumijanto

    2016-03-01

    Full Text Available ABSTRAK OPTIMASI LAJU ALIR MASSA DALAM PURIFIKASI PENDINGIN RGTT200K UNTUK PROSES KONVERSI KARBONMONOKSIDA. Karbonmonoksida adalah spesi yang sulit dipisahkan dari helium pendingin reaktor karena mempunyai ukuran molekul relatif kecil sehingga diperlukan proses konversi menjadi karbondioksida. Laju konversi karbonmonoksida dalam sistem purifikasi dipengaruhi oleh beberapa parameter diantaranya konsentrasi, temperatur dan laju alir massa. Dalam penelitian ini dilakukan optimasi laju alir massa dalam purifikasi pendingin RGTT200K untuk proses konversi karbonmonoksida. Optimasi dilakukan melalui simulasi proses konversi karbonmonoksida menggunakan perangkat lunak Super Pro Designer. Laju pengurangan spesi reaktan, laju pertumbuhan spesi antara dan spesi produk dalam kesetimbangan reaksi konversi dianalisis untuk memperoleh optimasi laju alir massa purifikasi terhadap proses konversi karbonmonoksida. Tujuan penelitian ini adalah menyediakan data laju alir massa purifikasi untuk pembuatan dasar desain sistem purifikasi helium pendingin RGTT200K. Hasil analisis menunjukkan bahwa pada laju alir massa 0,6 kg/detik proses konversi belum optimal, pada laju alir massa 1,2 kg/detik mencapai optimal dan pada laju alir 3,6 kg/detik s/d 12,0 kg/detik tidak efektif. Untuk memdukung dasar desain sistem purifikasi helium pendingin RGTT200K maka laju alir massa purifikasi untuk proses konversi karbonmonoksida digunakan laju alir massa 1,2 kg/detik. Kata kunci: Karbonmonoksida, konversi, purifikasi, laju alir massa, RGTT200K.   ABSTRACT OPTIMIZATION OF MASS FLOW RATE IN RGTT200K COOLANT PURIFICATION FOR CARBONMONOXIDE CONVERSION PROCESS. Carbonmonoxide is a species that is difficult to be separated from the reactor coolant helium because it has a relatively small molecular size.  So it needs a process of conversion from carbonmonoxide to carbondioxide. The rate of conversion of carbonmonoxide in the purification system is influenced by several parameters

  5. DESCRIPTION OF MODELING ANALYSES IN SUPPORT OF THE 200-ZP-1 REMEDIAL DESIGN/REMEDIAL ACTION

    Energy Technology Data Exchange (ETDEWEB)

    VONGARGEN BH

    2009-11-03

    The Feasibility Study/or the 200-ZP-1 Groundwater Operable Unit (DOE/RL-2007-28) and the Proposed Plan/or Remediation of the 200-ZP-1 Groundwater Operable Unit (DOE/RL-2007-33) describe the use of groundwater pump-and-treat technology for the 200-ZP-1 Groundwater Operable Unit (OU) as part of an expanded groundwater remedy. During fiscal year 2008 (FY08), a groundwater flow and contaminant transport (flow and transport) model was developed to support remedy design decisions at the 200-ZP-1 OU. This model was developed because the size and influence of the proposed 200-ZP-1 groundwater pump-and-treat remedy will have a larger areal extent than the current interim remedy, and modeling is required to provide estimates of influent concentrations and contaminant mass removal rates to support the design of the aboveground treatment train. The 200 West Area Pre-Conceptual Design/or Final Extraction/Injection Well Network: Modeling Analyses (DOE/RL-2008-56) documents the development of the first version of the MODFLOW/MT3DMS model of the Hanford Site's Central Plateau, as well as the initial application of that model to simulate a potential well field for the 200-ZP-1 remedy (considering only the contaminants carbon tetrachloride and technetium-99). This document focuses on the use of the flow and transport model to identify suitable extraction and injection well locations as part of the 200 West Area 200-ZP-1 Pump-and-Treat Remedial Design/Remedial Action Work Plan (DOEIRL-2008-78). Currently, the model has been developed to the extent necessary to provide approximate results and to lay a foundation for the design basis concentrations that are required in support of the remedial design/remediation action (RD/RA) work plan. The discussion in this document includes the following: (1) Assignment of flow and transport parameters for the model; (2) Definition of initial conditions for the transport model for each simulated contaminant of concern (COC) (i.e., carbon

  6. Pilot-scale treatability test plan for the 200-UP-1 groundwater Operable Unit

    Energy Technology Data Exchange (ETDEWEB)

    Wittreich, C.D.

    1994-05-01

    This document presents the treatability test plan for pilot-scale pump and treat testing at the 200-UP-1 Operable Unit. This treatability test plan has been prepared in response to an agreement between the US Department of Energy, the US Environmental Protection Agency, and the Washington State Department of Ecology, as documented in Hanford Federal Facility Agreement and Consent Order (Ecology et al. 1989a) Change Control Form M-13-93-03 (Ecology et al. 1994). The agreement also requires that, following completion of the activities described in this test plan, a 200-UP-1 Operable Unit interim remedial measure (IRM) proposed plan be developed for use in preparing an interim action record of decision (ROD). The IRM Proposed Plan will be supported by the results of the testing described in this treatability test plan, as well as by other 200-UP-1 Operable Unit activities (e.g., limited field investigation, development of a qualitative risk assessment). Once issued, the interim action ROD will specify the interim action for groundwater contamination at the 200-UP-1 Operable Unit. The approach discussed in this treatability test plan is to conduct a pilot-scale pump and treat test for the contaminant plume associated with the 200-UP-1 Operable Unit. Primary contaminants of concern are uranium and technetium-99; the secondary contaminant of concern is nitrate. The pilot-scale treatability testing presented in this test plan has as its primary purpose to assess the performance of aboveground treatment systems with respect to the ability to remove the primary contaminants in groundwater withdrawn from the contaminant plume.

  7. Feasibility study report for the 200-BP-1 operable unit. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-01

    This feasibility study (FS) examines a range of alternatives and provides recommendations for selecting a preferred altemative for remediating contamination at the 200-BP-1 operable unit. The 200-BP-1 operable unit is located in the center of the Hanford Site along the northern boundary of the 200 East Area. The 241-BY Tank Farm is located immediately to the south of the operable unit. 200-BP-1 is a source operable unit with contaminated soils associated primarily with nine inactive cribs (known as the 216-B cribs). These cribs were used for disposal of low-level radioactive liquid waste from U Plant uranium recovery operations, and waste storage tank condensate from the adjacent 241-BY Tank Farm. The cribs used for disposal of U Plant waste were in operation from 1955--1965, and the cribs used for disposal of tank condensate were in operation from 1965-1975. In addition to the cribs, four unplanned releases of radioactive materials have occurred within the operable unit. Contaminated surface soils associated with the unplanned releases have been consolidated over the cribs and covered with clean soil to reduce contaminant migration and exposure. Discharge of wastes to the cribs has resulted in soil and groundwater contamination. The groundwater is being addressed as part of the 200 East Aggregate Area groundwater operable unit. Contaminated soils at the site can be categorized by the types of contaminants, their distribution in the soil column, and the risk posed by the various potential exposure pathways. Below the clean soil cover, the near surface soils contain low-:levels of contamination with cesium-137, radium-226, strontium-90, thorium-228 and uranium. The lifetime incremental cancer risk associated with these soils if they were exposed at the surface is 9 {times} 10{sup 5}.

  8. Earth at 200 Ma: Global palaeogeography refined from CAMP palaeomagnetic data

    Science.gov (United States)

    Ruiz-Martínez, Vicente Carlos; Torsvik, Trond H.; van Hinsbergen, Douwe J. J.; Gaina, Carmen

    2012-05-01

    The Central Atlantic Magmatic Province was formed approximately 200 Ma ago as a prelude to the breakup of Pangea, and may have been a cause of the Triassic-Jurassic mass extinction. Based on a combination of (i) a new palaeomagnetic pole from the CAMP related Argana lavas (Moroccan Meseta Block), (ii) a global compilation of 190-210 Ma poles, and (iii) a re-evaluation of relative fits between NW Africa, the Moroccan Meseta Block and Iberia, we calculate a new global 200 Ma pole (latitude = 70.1° S, longitude = 56.7° E and A95 = 2.7°; N = 40 poles; NW Africa co-ordinates). We consider the palaeomagnetic database to be robust at 200 ± 10 Ma, which allows us to craft precise reconstructions near the Triassic-Jurassic boundary: at this very important time in Earth history, Pangea was near-equatorially centered, the western sector was dominated by plate convergence and subduction, while in the eastern sector, the Palaeotethys oceanic domain was almost consumed because of a widening Neothethys. We show that there has been negligible net displacement of the Moroccan Meseta relative to Africa since 200 Ma. We calculate a new fit between Iberia and NW Africa, showing that models inferring minor Cretaceous rotation and major Cretaceous sinistral translation of Iberia relative to Europe are inconsistent with palaeomagnetic Iberia-Africa fits at 200 Ma. During Pangea breakup (~ 195 Ma, opening of the Central Atlantic), and shortly after the CAMP outburst, Laurasia rotated clockwise relative to Gondwana around an Euler pole located in SE Iberia. The CAMP and its likely contribution to climate change, mass extinction and Pangea breakup profoundly changed planet Earth and we show that CAMP was sourced by a deep mantle plume that started its disturbing journey from the core-mantle boundary.

  9. Downregulation of CD47 and CD200 in patients with focal cortical dysplasia type IIb and tuberous sclerosis complex.

    Science.gov (United States)

    Sun, Fei-Ji; Zhang, Chun-Qing; Chen, Xin; Wei, Yu-Jia; Li, Song; Liu, Shi-Yong; Zang, Zhen-le; He, Jiao-Jiang; Guo, Wei; Yang, Hui

    2016-04-19

    Focal cortical dysplasia type IIb (FCD IIb) and tuberous sclerosis complex (TSC) are well-recognized causes of chronic intractable epilepsy in children. Accumulating evidence suggests that activation of the microglia/macrophage and concomitant inflammatory response in FCD IIb and TSC may contribute to the initiation and recurrence of seizures. The membrane glycoproteins CD47 and CD200, which are highly expressed in neurons and other cells, mediate inhibitory signals through their receptors, signal regulatory protein α (SIRP-α) and CD200R, respectively, in microglia/macrophages. We investigate the levels and expression pattern of CD47/SIRP-α and CD200/CD200R in surgically resected brain tissues from patients with FCD IIb and TSC, and the potential effect of soluble human CD47 Fc and CD200 Fc on the inhibition of several proinflammatory cytokines associated with FCD IIb and TSC in living epileptogenic brain slices in vitro. The level of interleukin-4 (IL-4), a modulator of CD200, was also investigated. Twelve FCD IIb (range 1.8-9.5 years), 13 TSC (range 1.5-10 years) patients, and 6 control cases (range 1.5-11 years) were enrolled. The levels of CD47/SIRP-α and CD200/CD200R were assessed by quantitative real-time polymerase chain reaction and western blot. The expression pattern of CD47/SIRP-α and CD200/CD200R was investigated by immunohistochemical analysis, and the cytokine concentrations were measured by enzyme-linked immune-sorbent assays. Both the messenger RNA and protein levels of CD47, SIRP-α, and CD200, as well as the mRNA level of IL-4, were downregulated in epileptogenic lesions of FCD IIb and TSC compared with the control specimens, whereas CD200R levels were not significantly changed. CD47, SIRP-α, and CD200 were decreasingly expressed in dysmorphic neuron, balloon cells, and giant cells. CD47 Fc and CD200 Fc could inhibit IL-6 release but did not suppress IL-1β or IL-17 production. Our results suggest that microglial activation may be

  10. Excess entropy and energy feedback from within cluster cores up to r200

    Science.gov (United States)

    Iqbal, Asif; Majumdar, Subhabrata; Nath, Biman B.; Ettori, Stefano; Eckert, Dominique; Malik, Manzoor A.

    2017-11-01

    We estimate the 'non-gravitational' entropy-injection profiles, ΔK, and the resultant energy feedback profiles, ΔE, of the intracluster medium for 17 clusters using their Planck Sunyaev-Zel'dovich and ROSAT X-ray observations, spanning a large radial range from 0.2r500 up to r200. The feedback profiles are estimated by comparing the observed entropy, at fixed gas mass shells, with theoretical entropy profiles predicted from non-radiative hydrodynamic simulations. We include non-thermal pressure and gas clumping in our analysis. The inclusion of non-thermal pressure and clumping results in changing the estimates for r500 and r200 by 10-20 per cent. When clumpiness is not considered it leads to an underestimation of ΔK ≈ 300 keV cm2 at r500 and ΔK ≈ 1100 keV cm2 at r200. On the other hand, neglecting non-thermal pressure results in an overestimation of ΔK ≈ 100 keV cm2 at r500 and underestimation of ΔK ≈ 450 keV cm2 at r200. For the estimated feedback energy, we find that ignoring clumping leads to an underestimation of energy per particle ΔE ≈ 1 keV at r500 and ΔE ≈ 1.5 keV at r200. Similarly, neglect of the non-thermal pressure results in an overestimation of ΔE ≈ 0.5 keV at r500 and underestimation of ΔE ≈ 0.25 keV at r200. We find entropy floor of ΔK ≈ 300 keV cm2 is ruled out at ≈3σ throughout the entire radial range and ΔE ≈ 1 keV at more than 3σ beyond r500, strongly constraining intracluster medium pre-heating scenarios. We also demonstrate robustness of results w.r.t. sample selection, X-ray analysis procedures, entropy modelling, etc.

  11. Wellfield strategy and recommendations for the 200 West Area carbon tetrachloride expedited response action

    Energy Technology Data Exchange (ETDEWEB)

    Rohay, V.J.

    1994-04-01

    On December 20, 1990, the US Environmental Protection Agency (EPA) and the Washington State Department of Ecology (Ecology) requested the US Department of Energy (DOE), Richland Field Office (RL) to proceed with the detailed planning, including nonintrusive field work, required to implement an Expedited Response Action (ERA) for removing carbon tetrachloride contamination in the unsaturated soils in the 200 West Area of the Hanford Site. The request was based on concerns that the carbon tetrachloride residing in the soils was continuing to spread to the groundwater and, if left unchecked, would significantly increase the area of groundwater contamination. The purpose of this ERA is to minimize carbon tetrachloride migration within the unsaturated zone beneath and,away from the carbon tetrachloride disposal sites in the 200 West Area.

  12. Hydrogeology of the Hanford Site Central Plateau – A Status Report for the 200 West Area

    Energy Technology Data Exchange (ETDEWEB)

    Last, George V.; Thorne, Paul D.; Horner, Jacob A.; Parker, Kyle R.; Bjornstad, Bruce N.; Mackley, Rob D.; Lanigan, David C.; Williams, Bruce A.

    2009-08-27

    The Remediation Decisions Support (RDS) function of the Soil and Groundwater Remediation Project (managed by CH2M HILL Plateau Remediation Company [CHPRC]) is responsible for facilitating the development of consistent data, parameters, and conceptual models to resolve technical issues and support efforts to estimate contaminant migration and impacts (i.e., the assessment process). In particular, the RDS function is working to update electronic data sources and conceptual models of the geologic framework and associated hydraulic and geochemical parameters to facilitate traceability, transparency, defensibility, and consistency in support of environmental assessments. This report summarizes the efforts conducted by Pacific Northwest National Laboratory (PNNL) scientists in fiscal year 2008 (FY08) that focused primarily on the 200 West Area, as well as a secondary effort initiated on the 200 East Area.

  13. Revised Methodology for Determining Cesium-137 Content of HN-200 Grout Containers

    Energy Technology Data Exchange (ETDEWEB)

    SHELOR, J.L.

    1999-08-31

    The purpose of this technical paper is to examine the accuracy of the existing method of determining the Cs-137 content of HN-200 grout containers and compare that accuracy to the accuracy attainable by other methods of measurement. The methods of measurement to be compared include: Contact measurements on a grouted container (existing method); Measurements at 5 feet from the surface of a grouted container; Measurements at 10 feet from a grouted container; Measurements on contact with the surface of an ungrouted container; Measurements at 5 feet from the surface of an ungrouted container; and Measurements at 10 feet from the surface of an ungrouted container. Once the most accurate and useable method is determined, the precepts for an operating procedure will be provided for determining the Cs-137 content of newly generated and future HN-200 grout containers as well as the grouted legacy containers currently stored in B Cell.

  14. Operation of the OK-4/Duke storage ring FEL below 200 nm

    CERN Document Server

    Litvinenko, V N; Pinayev, I V; Wu Yin

    2001-01-01

    For a number of years the wavelength of 200 nm was a psychological barrier for FEL oscillators. The progress towards short wavelength was marginal since the OK-4/VEPP-3 storage ring FEL lased at 240 nm in 1988. After 10 years, in 1998, the OK-4/Duke FEL and the NIJI-IV FEL group moved the limit to 217 and 212 nm, respectively. Improvements of the OK-4/Duke storage ring FEL gain above 10% and the use of custom manufactured mirror coatings brought the success in August 1999. The OK-4 FEL lased in the range from 193.7 to 209.8 nm using electron energies from 500 to 800 MeV. In this paper, we present the description of the OK-4/Duke FEL up-grades and the lasing results below 200 nm obtained in August and October of 1999.

  15. Shrub-inhabiting insects of the 200 Area Plateau, southcentral Washington.

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, L.E.

    1979-10-01

    This study characterizes the insects (including spiders) associated with major shrubs of the 200 Area Plateau on the Hanford Site in southcentral Washington. Big sagebrush (Artemisia tridentata), rabbitbrush (Chrysothamnus sp.) and hopsage (Grayia spinosa) were the three shrubs included in the study. Hemiptera (true bugs) and homoptera (bugs) were the two groups most abundant on sagebrush. Homoptera and Araneida (spiders) were the common inhabitants of rabbitbrush, and Orthoptera (grasshoppers), Coleoptera (beetles), and Araneida the taxa most frequently collected from hopsage. A discussion of the effects of insects on western native shrubs is included. None of the insect populations appeared to threaten the stability of shrub stands, which is important because of the erodability of 200 Area soils.

  16. A 30 MW, 200 MHz Inductive Output Tube for RF Accelerators

    Energy Technology Data Exchange (ETDEWEB)

    R. Lawrence Ives; Michael Read

    2008-06-19

    This program investigated development of a multiple beam inductive output tube (IOT) to produce 30 MW pulses at 200 MHz. The program was successful in demonstrating feasibility of developing the source to achieve the desired power in microsecond pulses with 70% efficiency. The predicted gain of the device is 24 dB. Consequently, a 200 kW driver would be required for the RF input. Estimated cost of this driver is approximately $1.25 M. Given the estimated development cost of the IOT of approximately $750K and the requirements for a test set that would significantly increase the cost, it was determined that development could not be achieved within the funding constraints of a Phase II program.

  17. NASA Green Flight Challenge: Conceptual Design Approaches and Technologies to Enable 200 Passenger Miles per Gallon

    Science.gov (United States)

    Wells, Douglas P.

    2011-01-01

    The Green Flight Challenge is one of the National Aeronautics and Space Administration s Centennial Challenges designed to push technology and make passenger aircraft more efficient. Airliners currently average around 50 passenger-miles per gallon and this competition will push teams to greater than 200 passenger-miles per gallon. The aircraft must also fly at least 100 miles per hour for 200 miles. The total prize money for this competition is $1.65 Million. The Green Flight Challenge will be run by the Comparative Aircraft Flight Efficiency (CAFE) Foundation September 25 October 1, 2011 at Charles M. Schulz Sonoma County Airport in California. Thirteen custom aircraft were developed with electric, bio-diesel, and other bio-fuel engines. The aircraft are using various technologies to improve aerodynamic, propulsion, and structural efficiency. This paper will explore the feasibility of the rule set, competitor vehicles, design approaches, and technologies used.

  18. OPTIMASI PENGGUNAAN HCl SEBAGAI LARUTAN PENGELUSI ITRIUM-90 DALAM DOWEX® 50WX8-200

    Directory of Open Access Journals (Sweden)

    Sulaiman Sulaiman

    2015-07-01

    Full Text Available OPTIMASI PENGGUNAAN HCl SEBAGAI LARUTAN PENGELUSI ITRIUM-90 DALAM DOWEX® 50WX8-200. Itrium-90 merupakan radionuklida pemancar β yang mempunyai waktu paruh 64,1 jam dan memancarkan energi β maksimum 2280 keV. Itrium-90 digunakan dalam kedokteran nuklir untuk keperluan terapi. Sistem generator 90Sr/90Y telah dikembangkan untuk mendapatkan 90Y bebas pengemban. Itrium-90 yang diperoleh dari generator 90Sr/90Y berbentuk radiokimia 90Y-sitrat. Bentuk radiokimia 90Y yang ideal untuk penandaan berbagai macam ligan yaitu 90YCl3. Untuk mendapatkan bentuk radiokimia 90Y yang diinginkan dilakukan serangkaian proses dengan metode penukar ion menggunakan resin Dowex® 50WX8-200. Dalam penelitian ini telah dilakukan optimasi penggunaan HCl untuk elusi 90Y dari resin dengan variasi konsentrasi HCl dan waktu kontak saat elusi 90Y dari resin. Pelepasan 90Y dari resin Dowex® 50WX8-200 tergantung pada konsentrasi HCl yang digunakan. Konsentrasi HCl semakin besar laju pelepasan 90Y dari 90Y-Dowex semakin besar.  Waktu kontak optimummenggunakan 5 mL HCl 12 N adalah 60 menit dengan hasil  9,4 %. Hasil uji 90Y setelah dielusi dari Dowex® 50WX8-200 memberikan informasi radionuklida 90Y yang diperoleh dalam bentuk radiokimia 90YCl3.   OPTIMIZATION OF USE HCl AS SOLUTION FOR ELUTION ITRIUM-90 IN DOWEX® 50WX8- 200. Yttrium-90 is a β emitter radionuclide with a half life of 64.1 hours and emits the maximum β energy at 2280 keV. Yttrium-90 radionuclide is widely used in nuclear medicine for therapeutic purposes. 90Sr/90Y generator system has been developed to obtain carrier-free 90Y. Yttrium-90 were obtained from the 90Sr/90Y generator in the form of 90Y-citrate radiochemical. The 90Y ideal for tagging ligands is in the form of 90YCl3. To obtain the desired radiochemical a series of processes with ion exchange resin method is performed using Dowex® 50WX8-200. In this study optimization of the use of HCl for has been carried out 90Y elution from the resin with

  19. Iatrogenic gall bladder perforations in laparoscopic cholecystectomy: an audit of 200 cases

    DEFF Research Database (Denmark)

    Zubair, M; Habib, L; Mirza, M R

    2010-01-01

    underwent laparoscopic cholecystectomy for symptomatic cholelithiasis at Jamal Noor Hospital and Hamdard University Hospital, Karachi from January 2007 to January 2009. Video recording of all 200 laparoscopic cholecystectomies were analyzed for the IGBP. The different factors; sex of the patient, type......This study was done to evaluate the frequency of iatrogenic gall bladder perforation (IGBP) in laparoscopic cholecystectomy and to determine its association with gender, adhesions in right upper quadrant and types of gall bladder. This retrospective descriptive study included 200 patients who...... by grasping forceps in 24(47.06%) patients. In 33(64.71%) patients perforations occurred during dissection of gall bladder from liver bed, in 2(3.92%) during adhesiolysis and in 16(31.37%) during retraction maneuvers. Perforation of gall bladder occurred in 25.5% of patients during laparoscopic...

  20. Assessing personality change in psychotherapy with the SWAP-200: a case study.

    Science.gov (United States)

    Lingiardi, Vittorio; Shedler, Jonathan; Gazzillo, Francesco

    2006-02-01

    Many studies document the efficacy of psychotherapy for acute syndromes such as depression, but less is known about personality change in patients treated for personality pathology. The Shedler-Westen Assessment Procedure (SWAP-200; Westen & Shedler, 1999a, 1999b) is an assessment tool that measures a broad spectrum of personality constructs and is designed to bridge the gap between the clinical and empirical traditions in personality assessment. In this article, we demonstrate the use of the SWAP-200 as a measure of change in a case study of a patient diagnosed with borderline personality disorder. We collected assessment data at the start of treatment and after 2 years of psychotherapy. The findings illustrate the personality processes targeted in intensive psychotherapy for borderline personality.

  1. Lithium based alloy-thionyl chloride cells for applications at temperatures to 200 C

    Science.gov (United States)

    Kane, P.; Marincic, N.; Epstein, J.; Lindsey, A.

    A long-life lithium battery for industrial applications at temperatures up to 200 C was developed by combining Li-based alloy anodes with oxyhalide electrolytes. Cathodes were fabricated by rolling the blend of polycarbonomonofluoride, a conductive carbon additive, and a binder, while anodes were fabricated as those used in oxyhalide cells, incorporating a modified anode current collector designed to prevent the formation of 'lithium islands' at the end of discharge; nonwoven glass fiber separators were pretreated to remove excessive binders and lubricants. Various active electrode surface areas were combined with a corresponding thickness of electrodes and separators, matched in capacity. Tests of the high-rate electrode structure, using Li-Mg alloy anode in conjunction with thionyl chloride electrolyte, have demonstrated that the battery with this anode can be used under abusive conditions such as short circuit and external heating (at 175 C). Raising the operating temperature to 200 C did require some modifications of regular cell hardware.

  2. Prevalence of taurodontism found in radiographic dental examination of 1,200 young adult Israeli patients.

    Science.gov (United States)

    Shifman, A; Chanannel, I

    1978-07-01

    The prevalence of taurodontism was studied radiographically in 1,200 young adult Israeli patients. In order to differentiate taurodont teeth from normal teeth, three types of taurodontism (meso-, hypo- and hypertaudodontism) were defined in biometric terms, using radiographic features of molar morphology. All three types according to Shaw's classification were seen. Taurodontism was found to occur in 5.6% of 1,200 individuals and in 1.5% of the 10,204 molar teeth examined. The mandibular second molar was found to be the most prone, being involved in two thirds of all cases found. Hypertaurodontism was found only in three cases, in the third molars. The conditions was seen to involve single and multiple teeth, both unilaterally and bilaterally, with the latter being most predominant.

  3. Untersuchungen zur Sorptionsreversibilität von organischen Schadstoffen in Aktivkohle, Holzkohle und Zeolith Y-200

    Science.gov (United States)

    ElHaddad, Engy; Ensinger, Wolfgang; Schüth, Christoph

    2013-09-01

    Numerous studies have shown that sorption of organic contaminants in soils is dominated by the natural organic carbon content ( C org) of the soil. However, it is still under discussion whether sorption processes are fully reversible or whether an irreversibly sorbed contaminant fraction remains in the soil. This is especially important when considering soil remediation measures and its targets. In multi-stage sorption-desorption batch experiments with TCE, PCE, ortho-xylene and para-xylene and with the sorbents activated carbon, charcoal and a hydrophobic zeolite Y-200, the reversibility of sorption was studied. It could be shown that the structural features of the sorbents are of ample importance for the occurrence of a desorption-resistant fraction. While sorption was mainly reversible for the micro-porous zeolite Y-200 with a rigid pore network, charcoal and the activated carbon showed significant desorption hysteresis. However, following a subsequent sorption step, this fraction eventually desorbs and is re-mobilized.

  4. Genomic structure in Europeans dating back at least 36,200 years

    DEFF Research Database (Denmark)

    Seguin-Orlando, Andaine; Korneliussen, Thorfinn Sand; Sikora, Martin

    2014-01-01

    European Neolithic farmers. We find that Kostenki 14 contains more Neandertal DNA that is contained in longer tracts than present Europeans. Our findings reveal the timing of divergence of western Eurasians and East Asians to be more than 36,200 years ago and that European genomic structure today dates......The origin of contemporary Europeans remains contentious. We obtained a genome sequence from Kostenki 14 in European Russia dating from 38,700 to 36,200 years ago, one of the oldest fossils of anatomically modern humans from Europe. We find that Kostenki 14 shares a close ancestry with the 24......,000-year-old Mal'ta boy from central Siberia, European Mesolithic hunter-gatherers, some contemporary western Siberians, and many Europeans, but not eastern Asians. Additionally, the Kostenki 14 genome shows evidence of shared ancestry with a population basal to all Eurasians that also relates to later...

  5. Effects of Aloe barbadensis Mill. extract (AVH200®) on human blood T cell activity in vitro.

    Science.gov (United States)

    Ahluwalia, Bani; Magnusson, Maria K; Isaksson, Stefan; Larsson, Fredrik; Öhman, Lena

    2016-02-17

    Aloe barbadensis Mill. (Aloe vera) is a widely used medicinal plant well reputed for its diverse therapeutic applications. It has been used for thousands of years in folk medicine to treat various conditions and the Aloe vera gel has been reported to possess anti-inflammatory as well as immunostimulatory and immunomodulatory properties. However, the mode of action is still unclear. The aim of this study was determine the effects of two well-defined A. barbadensis Mill. extracts AVH200® and AVE200 on human blood T cells in vitro. Peripheral blood mononuclear cells (PBMC) from healthy donors were stimulated polyclonally in the presence or absence of AVH200® and AVE200. The T cell phenotype was investigated by flow cytometry, cell proliferation was determined by CFSE dye and thymidine assay, respectively and cytokine secretion was determined by MSD® Multi-Spot Assay system and ELISA. The presence of AVH200® resulted in a reduced expression of CD25 among CD3(+) T cells and suppression of T cell proliferation in a dose dependent manner. Furthermore, AVH200® reduced the expression of CD28 on CD3(+) T cells. AVH200® also reduced the secretion of IL-2, IFN-γ and IL-17A in PBMC cultures. The AVH200® dose dependent reduction in T cell activation and proliferation recorded in the cell cultures was not due to apoptosis or cell death. Additionally, AVH200® was found to be more effective as compared to AVE200 in reducing T cell activation and proliferation. AVH200® has the potential to reduce the activation, proliferation and cytokine secretion of healthy human blood T cells. Our study suggests that AVH200® has a suppressive effect on human blood T cells in vitro. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  6. MiR-200a enhances the migrations of A549 and SK-MES-1 cells by ...

    Indian Academy of Sciences (India)

    2013-07-14

    Jul 14, 2013 ... MicroRNA-200a (miR-200a) has been reported to regulate tumour progression in several tumours; however, little is known about its role in non-small cell lung cancer cells (NSCLCs). Here, we found that miR-200a was up-regulated in. A549 and SK-MES-1 cells compared with normal lung cells HELF.

  7. Fundamental Frequency Tuning and Its Influence on LHC 200MHz ACN Cavity

    CERN Document Server

    Linnecar, Trevor Paul R; Tückmantel, Joachim; CERN. Geneva. SPS and LHC Division

    2001-01-01

    To study the influence of the tuner on the fundamental mode frequency, the Q factor as well as the shunt impedance of the LHC 200MHz ACN cavities, 3D simulations have been done in the frequency domain using MAFIA. Curves giving the variation of RF frequency and other RF parameters with tuner position relative to the inner surface of the cavity have been obtained for the fundamental mode. This paper details the simulation results.

  8. Contaminant Attenuation and Transport Characterization of 200-DV-1 Operable Unit Sediment Samples

    Energy Technology Data Exchange (ETDEWEB)

    Truex, Michael J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Szecsody, James E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Qafoku, Nikolla [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Strickland, Christopher E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Moran, James J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lee, Brady D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Snyder, Michelle M.V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lawter, Amanda R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Resch, Charles T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Gartman, Brandy N. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zhong, Lirong [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Nims, Megan K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Saunders, Danielle L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Williams, Benjamin D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Horner, Jacob A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Leavy, Ian I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Baum, Steven R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Christiansen, Beren B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Clayton, Ray E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); McElroy, Erin M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Appriou, Delphine [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Tyrrell, Kimberly J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Striluk, Miranda L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-05-15

    A laboratory study was conducted to quantify contaminant attenuation processes and associated contaminant transport parameters that are needed to evaluate transport of contaminants through the vadose zone to the groundwater. The laboratory study information, in conjunction with transport analyses, can be used as input to evaluate the feasibility of Monitored Natural Attenuation and other remedies for the 200-DV-1 Operable Unit at the Hanford Site.

  9. From nuclei to nucleons. [10 to 200 MeV/nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Scott, D.K.

    1978-03-01

    Some initial experiments in the intermediate energy region between 10 and 200 MeV/nucleon, which is largely unexplored and poorly understood is considered as regards some initial experiments in this energy region. Included are the emission of complex fragments, localization in heavy ion reactions, coincidence experiments between light and heavy fragments, and the emission of light particles in heavy ion collisions. Some initial results in the region between 20 and 100 MeV/nucleon are presented. 41 references. (JFP)

  10. Strange particle production in sulphur-sulphur interactions at 200 GeV/c per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Bayes, A.C. [Birmingham Univ. (United Kingdom); Abatzis, S.; Andrighetto, A.; Antinori, F.; Barnes, R.P.; Benayoun, M.; Beusch, W.; Blaes, R.; Bloodworth, I.J.; Bohm, J.; Bravar, A.; Carney, J.N.; Cruz, B. de la; Clewer, S.; Davies, J.P.; Di Bari, D.; Dodenhoff, C.J.; Dufey, J.P.; Elia, D.; Engelfried, J.; Evans, D.; Fini, R.; French, B.R.; Ghidini, B.; Helstrup, H.; Holme, A.K.; Jacholkowski, A.; Kachelhoffer, T.; Kahane, J.; Katchanov, V.A.; Kinson, J.B.; Kirk, A.; Knudson, K.; Ladron de Guevara, P.; Lassalle, J.C.; Lenti, V.; Leruste, P.; Loconsole, R.A.; Loevhoeiden, G.; Manzari, V.; Martens, K.; Michalon, A.; Morando, M.; Mueller, U.; Navach, F.; Narjoux, J.L.; Passaseo, M.; Pellegrini, F.; Penzo, A.; Quercigh, E.; Ricci, R.; Sandor, L.; Safarik, K.; Segato, G.; Siebert, H.W.; Singovsky, A.V.; Sene, M.; Sene, R.; Thorsteinsen, T.F.; Undheim, G.; Urban, J.; Vassiliadis, G.; Villalobos Baillie, O.; Volte, A.; Voltolini, C.; Votruba, M.F.; Waelder, G.; Zavada, P.; WA94 Collaboration

    1994-01-03

    The WA94 experiment is designed to study the production of strange and multistrange baryons and antibaryons in sulphur-sulphur interactions at 200 GeV/c per nucleon. The Omega spectrometer, equipped with MWPCs operated in the butterfly mode, is used to measure particles in the central rapidity window with p{sub T}>1.0 GeV/c. Preliminary results are presented on the production of {Lambda}, anti {Lambda}, {Xi}{sup -} and anti {Xi}{sup -}. (orig.)

  11. Patient SWAP-200 Personality Dimensions and FFM Traits: Do They Predict Therapist Responses?

    Science.gov (United States)

    Tanzilli, Annalisa; Lingiardi, Vittorio; Hilsenroth, Mark

    2017-08-24

    The main aim of this study was to examine the relationship between therapists' emotional responses and patients' personality evaluated by 3 dimensional diagnostic approaches empirically derived from the Shedler-Westen Assessment Procedure-200 (SWAP-200; Westen & Shedler, 1999a, 1999b): Two of these rely on the 5-factor model (FFM) domains, that were assessed with different SWAP-200 FFM versions developed by Shedler and Westen (SW-FFM scales; 2004) and McCrae, Löckenhoff, and Costa (MLC-FFM scales; 2005); the third approach is based on a multifaceted model of personality syndromes (SWAP personality dimension scales; see Shedler & Westen, 2004). A national sample of psychiatrists and psychologists (N = 166) of various theoretical orientations completed the Therapist Response Questionnaire (TRQ; Zittel Conklin & Westen, 2003) to identify patterns of therapist response, and the SWAP-200 to assess personality regarding a patient currently in their care. The findings showed good levels of construct validity between the SW-FFM and MLC-FFM scales, with the exception of the Openness trait. Moreover, specific SW-FFM and MLC-FFM scales were significantly associated with distinct SWAP personality dimension scales according in a conceptually meaningful nomological network. Although there were significant, theoretically coherent, and systematic relationships between therapists' responses and patients' personality features, overall the contribution of the SW-FFM and MLC-FFM traits in predicting therapists' responses was less sizable than the SWAP personality dimensions. These results seem to confirm the diagnostic and therapeutic value of countertransference as an essential tool in understanding psychological traits/dimensions that underlie the patients' psychopathology, both from within and outside of the FFM. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  12. A 200 MHz SC-RF System for the HL-LHC

    CERN Document Server

    Calaga, Rama

    2016-01-01

    A quarter wave β=1 superconducting cavity at 200 MHz is proposed for the LHC as an alternative to the present 400 MHz RF system. The primary motivation of such a system would be to accelerate higher intensity and longer bunches with improved capture efficiency. Advantages related to minimizing electron cloud effects, intra-beam scattering, heating and the possibility of luminosity levelling with bunch length are described. Some considerations related to cavity optimization, beam loading and technological challenges are addressed.

  13. Magnetohydrodynamics (MHD) Engineering Test Facility (ETF) 200 MWe power plant Conceptual Design Engineering Report (CDER)

    Science.gov (United States)

    1981-01-01

    The reference conceptual design of the magnetohydrodynamic (MHD) Engineering Test Facility (ETF), a prototype 200 MWe coal-fired electric generating plant designed to demonstrate the commercial feasibility of open cycle MHD, is summarized. Main elements of the design, systems, and plant facilities are illustrated. System design descriptions are included for closed cycle cooling water, industrial gas systems, fuel oil, boiler flue gas, coal management, seed management, slag management, plant industrial waste, fire service water, oxidant supply, MHD power ventilating

  14. Systematic Study of Trace Radioactive Impurities in Candidate Construction Materials for EXO-200

    Energy Technology Data Exchange (ETDEWEB)

    Leonard, D.S.; Grinberg, P.; Weber, P.; Baussan, E.; Djurcic, Z.; Keefer, G.; Piepke, A.; Pocar, A.; Vuilleumier, J.-L.; Vuilleumier, J.-M.; Akimov, D.; Bellerive, A.; Bowcock, M.; Breidenbach, M.; Burenkov, A.; Conley, R.; Craddock, W.; Danilov, M.; DeVoe, R.; Dixit, M.; Dolgolenko, A.; /Alabama U. /NRC-INMS /Neuchatel U. /Stanford U., Phys. Dept. /SLAC /Colorado State U. /Laurentian U. /Maryland U. /UC, Irvine

    2007-10-24

    The Enriched Xenon Observatory (EXO) will search for double beta decays of 136Xe. We report the results of a systematic study of trace concentrations of radioactive impurities in a wide range of raw materials and finished parts considered for use in the construction of EXO-200, the first stage of the EXO experimental program. Analysis techniques employed, and described here, include direct gamma counting, alpha counting, neutron activation analysis, and high-sensitivity mass spectrometry.

  15. 200 TW 45 fs laser based on optical parametric chirped pulse amplification.

    Science.gov (United States)

    Lozhkarev, V V; Freidman, G I; Ginzburg, V N; Katin, E V; Khazanov, E A; Kirsanov, A V; Luchinin, G A; Mal'shakov, A N; Martyanov, M A; Palashov, O V; Poteomkin, A K; Sergeev, A M; Shaykin, A A; Yakovlev, I V; Garanin, S G; Sukharev, S A; Rukavishnikov, N N; Charukhchev, A V; Gerke, R R; Yashin, V E

    2006-01-09

    200 TW peak power has been achieved experimentally using a Cr:forsterite master oscillator at 1250 nm, a stretcher, three optical parametrical amplifiers based on KD*P (DKDP) crystals providing 14.5 J energy in the chirped pulse at 910 nm central wavelength, and a vacuum compressor. The final parametrical amplifier and the compressor are described in detail. Scaling of such architecture to multipetawatt power is discussed.

  16. $200,000 Grants Awarded to CCR Researchers for HIV/AIDS Studies | Poster

    Science.gov (United States)

    By Nancy Parrish, Staff Writer Earlier this year, the Office of AIDS Research (OAR) awarded two, two-year grants of $200,000 each to Anu Puri, Ph.D., and Robert Blumenthal, Ph.D., both of the Center for Cancer Research (CCR) Nanobiology Program, and to Eric Freed, Ph.D., of the HIV Drug Resistance Program, for their research on potential new treatments for HIV.

  17. MicroRNA-200c modulates DUSP-1 expression in diabetes-induced cardiac hypertrophy.

    Science.gov (United States)

    Singh, Gurinder Bir; Raut, Satish K; Khanna, Sanskriti; Kumar, Akhilesh; Sharma, Saurabh; Prasad, Rishikesh; Khullar, Madhu

    2017-01-01

    Mitogen-activated protein kinases (MAPKs) (ERK1/2, JNK, and p38) are upregulated in diabetic cardiomyopathy (DCM). Dual-specific phosphatase-1 (DUSP-1) has been reported to regulate the activity of MAPKs in cardiac hypertrophy; however, the role of DUSP-1 in regulating MAPKs activity in DCM is not known. MicroRNAs have been reported to regulate the expression of several genes in hypertrophied failing hearts. However, little is known about the microRNAs regulating DUSP-1 expression in diabetes-related cardiac hypertrophy. In the present study, we investigated the role of DUSP-1 and miR-200c in diabetes-induced cardiac hypertrophy. DCM was induced in Wistar rats by low-dose Streptozotocin high-fat diet for 12 weeks. Cardiac expression of ERK, p-38, JNK, DUSP-1, miR-200c, and hypertrophy markers (ANP and β-MHC) was studied in DCM in control rats and in high-glucose (HG)-treated rat neonatal cardiomyocytes. miR-200c inhibition was performed to validate DUSP-1 as target. A significant increase in phosphorylated ERK, p38, and JNK was observed in DCM model and in HG-treated cardiomyocytes (p 1 was significantly decreased in diabetes group and in HG-treated cardiomyocytes (p 1 causing decreased expression of phosphorylated ERK, p38, and JNK and attenuated cardiomyocyte hypertrophy in HG-treated cardiomyocytes. miR-200c plays a role in diabetes-associated cardiac hypertrophy by modulating expression of DUSP-1.

  18. Magnetohydrodynamics (MHD) Engineering Test Facility (ETF) 200 MWe power plant. Design Requirements Document (DRD)

    Science.gov (United States)

    Rigo, H. S.; Bercaw, R. W.; Burkhart, J. A.; Mroz, T. S.; Bents, D. J.; Hatch, A. M.

    1981-01-01

    A description and the design requirements for the 200 MWe (nominal) net output MHD Engineering Test Facility (ETF) Conceptual Design, are presented. Performance requirements for the plant are identified and process conditions are indicated at interface stations between the major systems comprising the plant. Also included are the description, functions, interfaces and requirements for each of these major systems. The lastest information (1980-1981) from the MHD technology program are integrated with elements of a conventional steam electric power generating plant.

  19. Project W-314 Specific Test and Evaluation Plan for 200E Waste Transfer System

    Energy Technology Data Exchange (ETDEWEB)

    HAMMERS, J.S.

    2000-02-25

    The purpose of this Specific Test and Evaluation Plan (STEP) is to provide a detailed written plan for the systematic testing of the newly constructed 200E Waste Transfer System in the W-314 Project. The STEP provides the outline for test and evaluation methods that verify the system's performance and compliance to the established Project design criteria. The STEP is a ''lower tier'' document based on the W-314 Test & Evaluation Plan (TEP).

  20. Prioritization and accelerated remediation of groundwater contamination in the 200 Areas of the Hanford Site, Washington

    Energy Technology Data Exchange (ETDEWEB)

    Wittreich, C.D.; Ford, B.H.

    1993-04-01

    The Hanford Site, operated by the US Department of Energy (DOE), occupies about 1,450 km{sup 2} (560 mi{sup 2}) of the southeastern part of Washington State north of the confluence of the Yakima and Columbia Rivers. The Hanford Site is organized into numerically designated operational areas. The 200 Areas, located near the center of the Hanford Site, encompasses the 200 West, East and North Areas and cover an area of over 40 km{sup 2}. The Hanford Site was originally designed, built, and operated to produce plutonium for nuclear weapons using production reactors and chemical reprocessing plants. Operations in the 200 Areas were mainly related to separation of special nuclear materials from spent nuclear fuel and contain related chemical and fuel processing and waste management facilities. Large quantities of chemical and radioactive waste associated with these processes were often disposed to the environment via infiltration structures such as cribs, ponds, ditches. This has resulted in over 25 chemical and radionuclide groundwater plumes, some of which have reached the Columbia River. An Aggregate Area Management Study program was implemented under the Hanford Federal Facility Agreement and Consent Order to assess source and groundwater contamination and develop a prioritized approach for managing groundwater remediation in the 200 Areas. This included a comprehensive evaluation of existing waste disposal and environmental monitoring data and the conduct of limited field investigations (DOE-RL 1992, 1993). This paper summarizes the results of groundwater portion of AAMS program focusing on high priority contaminant plume distributions and the groundwater plume prioritization process. The objectives of the study were to identify groundwater contaminants of concern, develop a conceptual model, refine groundwater contaminant plume maps, and develop a strategy to expedite the remediation of high priority contaminants through the implementation of interim actions.

  1. Equipping an FPGA-Based Mars Rover With an LN-200 IMU

    Science.gov (United States)

    Zola, Nicholas J.

    2005-01-01

    The Mars Exploration Rovers (MER) currently navigating the surface of Mars are outfitted with an advanced stereovision correlation algorithm which allows them to "see" three-dimensionally and autonomously avoid obstac'les in their path. A bottleneck of this system is that it is computationally intense and requires 3 minutes of processing for every correlated image and path choice. Taking advantage of the optimization and reprogrammability of FPGAs, the Mobility Avionics lab has reduced this process to under a second. The lab is demonstrating the advancement with a prototype rover, complete with an LN-200 inertial measurement unit (IMU), which is a flight spare from MER. The LN-200 is a space-grade, six degrees-of-freedom IMU using three fiber-optic gyroscopes and three silicon accelerometers and no moving parts. It has particular power-sequencing needs and communicates with a specialized serial protocol (SDLC over RS-422), requiring specific hardware and software for proper functionality and interfacing with an FPGA. The process of incorporating the LN-200 into the system is described herein.

  2. CO tolerance by the PEMFC operational at temperatures up to 200°C

    DEFF Research Database (Denmark)

    Li, Qingfeng; He, Ronghuan; Gao, Ji-An

    2003-01-01

    The CO poisoning effect on carbon-supported platinum catalysts in polymer electrolyte membrane fuel cells has been investigated in a temperature range from 125 to 200°C with the phosphoric acid-doped polybenzimidazole membranes as electrolyte. The effect is very temperature-dependent and can be s...... densities lower than 0.25 A/cm2. For comparison, the tolerance is only 0.0025 % CO (25 ppm) at 80°C at current densities up to 0.15 A/cm². The effect of CO2 in hydrogen was also studied. At 175°C, 25% CO2 in the fuel stream showed only the dilution effect.......The CO poisoning effect on carbon-supported platinum catalysts in polymer electrolyte membrane fuel cells has been investigated in a temperature range from 125 to 200°C with the phosphoric acid-doped polybenzimidazole membranes as electrolyte. The effect is very temperature-dependent and can...... be sufficiently suppressed at elevated temperature. By defining a poisoning factor as less than 2% of power loss due to the poisoning effect, it is evaluated that 3% CO in hydrogen can be tolerated at current densities up to 0.7 A/cm2 at 200oC, while at 125oC 0.1% CO in hydrogen can be tolerated at current...

  3. INTERACTIONS OF 200-GeV/c PROTONS WITH EMULSION NUCLEI, CHARGED PARTICLE MULTIPLICITIES

    Energy Technology Data Exchange (ETDEWEB)

    Anzon, Z.V.; Boos, E.G.; Chasnikov, I.Ya.; Kanygina, E.K.; Khomenko, K.I.; Pavlova, N.P.; Takibaev, Zh.S.; /Phys. Inst., Almaty; Lepekhin, F.G.; Simonov, B.B.; /St. Petersburg, INP; Bogdanov, V.G.; Fadina, E.V.; /Khlopin Radium Inst. /Lebedev Inst. /Moscow State U. /Tashkent, FTI

    1974-01-01

    The experimental data on the multiplicity distributions for various kinds of secondaries produced in the proton-nucleus interactions in emulsion at 200 GeV/c and the correlations between them are presented and discussed. All the characteristics of heavy prongs (mean values , , , their distributions and correlations) are independent (or have a very weak dependence) on the collisions energy in the range 20-200 GeV/c. The data contradict to the cascade-evaporation model and qualitatively agree with the mechanism of particle emission via the long-lived intermediate states. The observed weak A-dependence ({approx} A{sup 0.15}) of shower particle distributions is in agreement with the calculated ones according to the simplified two-step model. It is shown that the n{sub s}-distributions agree well with KNO scaling law in the 67-200 GeV/c range, but the form of universal {psi}(n{sub s/n{sub s}})-function has a weak A-dependence.

  4. [P200 parameters in patients with diabetes mellitus type 2 (DM2)].

    Science.gov (United States)

    Hernández, Oscar H; Aguirre-Manzo, Luisa; Ye-Ehuan, Freddy; García-Martínez, Rolando; Maldonado-Velázquez, Guadalupe

    2016-01-01

    A complication underserved in diabetic patients is the cognitive deficits that can reach dementia. Studying the association between electrophysiological, neuropsychological, and biochemical measures could provide a breakthrough in the understanding of this phenomenon. To compare P200 parameters between subjects with and without diabetes mellitus type 2 and to determine their relationship with biochemical and neuropsychological indicators. This is an observational, prospective, transversal and analytical study. Seventy-four participants were divided into two groups: 37 with diabetes mellitus type 2, and 37 subjects as controls. P200 latency, amplitude, and rate of rise to somatosensory stimuli were measured and related to the Mini Mental State Examination (MMSE) test and blood glucose and glycosylated hemoglobin. Diabetics showed longer latency (p < 0.042, 1-tail) and lower MMSE score (p < 0.0001) than controls. Negative associations of amplitude and rising rate with glycosylated hemoglobin were observed in patients (p < 0.025); also, between amplitude and blood glucose (p < 0.038, 1-tail) and between MMSE score and time with diabetes mellitus type 2 (p < 0.007). The P200 parameters of the somatosensory system are sensitive to metabolic deterioration of diabetic patients, so its use in monitoring the cognitive state of patients is recommended.

  5. ALTERNATIVE REMEDIATION TECHNOLOGY STUDY FOR GROUNDWATER TREATMENT AT 200-PO-1 OPERABLE UNIT AT HANFORD SITE

    Energy Technology Data Exchange (ETDEWEB)

    DADO MA

    2008-07-31

    This study focuses on the remediation methods and technologies applicable for use at 200-PO-I Groundwater Operable Unit (OU) at the Hanford Site. The 200-PO-I Groundwater au requires groundwater remediation because of the existence of contaminants of potential concern (COPC). A screening was conducted on alternative technologies and methods of remediation to determine which show the most potential for remediation of groundwater contaminants. The possible technologies were screened to determine which would be suggested for further study and which were not applicable for groundwater remediation. COPCs determined by the Hanford Site groundwater monitoring were grouped into categories based on properties linking them by remediation methods applicable to each COPC group. The screening considered the following criteria. (1) Determine if the suggested method or technology can be used for the specific contaminants found in groundwater and if the technology can be applied at the 200-PO-I Groundwater au, based on physical characteristics such as geology and depth to groundwater. (2) Evaluate screened technologies based on testing and development stages, effectiveness, implementability, cost, and time. This report documents the results of an intern research project conducted by Mathew Dado for Central Plateau Remediation in the Soil and Groundwater Remediation Project. The study was conducted under the technical supervision of Gloria Cummins and management supervision of Theresa Bergman and Becky Austin.

  6. The integration of InGaP LEDs with CMOS on 200 mm silicon wafers

    Science.gov (United States)

    Wang, Bing; Lee, Kwang Hong; Wang, Cong; Wang, Yue; Made, Riko I.; Sasangka, Wardhana Aji; Nguyen, Viet Cuong; Lee, Kenneth Eng Kian; Tan, Chuan Seng; Yoon, Soon Fatt; Fitzgerald, Eugene A.; Michel, Jurgen

    2017-02-01

    The integration of photonics and electronics on a converged silicon CMOS platform is a long pursuit goal for both academe and industry. We have been developing technologies that can integrate III-V compound semiconductors and CMOS circuits on 200 mm silicon wafers. As an example we present our work on the integration of InGaP light-emitting diodes (LEDs) with CMOS. The InGaP LEDs were epitaxially grown on high-quality GaAs and Ge buffers on 200 mm (100) silicon wafers in a MOCVD reactor. Strain engineering was applied to control the wafer bow that is induced by the mismatch of coefficients of thermal expansion between III-V films and silicon substrate. Wafer bonding was used to transfer the foundry-made silicon CMOS wafers to the InGaP LED wafers. Process trenches were opened on the CMOS layer to expose the underneath III-V device layers for LED processing. We show the issues encountered in the 200 mm processing and the methods we have been developing to overcome the problems.

  7. Lead 207, 208 (n, xn gamma) reactions for neutron energies up to 200 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Pavlik, A.; Vonach, H. [Univ. Wien (Austria). Inst. fuer Radiumforschung und Kernphysik; Chadwick, M.B.; Haight, R.C.; Nelson, R.O.; Wender, S.A.; Young, P.G. [Los Alamos National Lab., NM (United States)

    1994-07-01

    High-resolution {gamma}-ray spectra from the interaction of neutrons in the energy range from 3 to 200 MeV with {sup 207,208}Pb were measured with the white neutron source at the WNR facility at Los Alamos National Laboratory. From these data, excitation functions for prominent {gamma} transitions in {sup 200,202,204,206,207,208}Pb were derived from threshold to 200 MeV incident neutron energy. These {gamma}-production cross sections represent formation cross sections for excited states of the residual nuclei. The results are compared with the predictions of nuclear reaction calculations based on the exciton model for precompound emission, the Hauser-Feshbach theory for compound nuclear decay, and coupled channels calculations to account for direct excitation of collective levels. Good agreement was obtained over the entire energy range covered in the experiment with reasonable model parameters. The results demonstrate that multiple preequilibrium emission has to be taken into account above about 40 MeV, and that the level density model of Ignatyuk should be used instead of the Gilbert-Cameron and back-shifted Fermi-gas models if excitation energies exceed about 30 MeV.

  8. Regulation of miR-200c by nuclear receptors PPAR{alpha}, LRH-1 and SHP

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yuxia; Yang, Zhihong [Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84132 (United States); Department of Oncological Science, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84132 (United States); Whitby, Richard [Department of Chemistry, University of Southampton, Southampton, Hants SO17 1BJ (United Kingdom); Wang, Li, E-mail: l.wang@hsc.utah.edu [Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84132 (United States); Department of Oncological Science, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84132 (United States)

    2011-12-09

    Highlights: Black-Right-Pointing-Pointer Knockdown of PPAR{alpha} and LRH-1 abolishes miR-200c inhibition of HCC cell migration. Black-Right-Pointing-Pointer SHP represses miR-200c expression via inhibition of the activity of PPAR{alpha} and LRH-1. Black-Right-Pointing-Pointer RJW100 exhibits strong ability to downregulate ZEB1 and ZEB2 proteins. -- Abstract: We investigated regulation of miR-200c expression by nuclear receptors. Ectopic expression of miR-200c inhibited MHCC97H cell migration, which was abrogated by the synergistic effects of PPAR{alpha} and LRH-1 siRNAs. The expression of miR-200c was decreased by PPAR{alpha}/LRH-1 siRNAs and increased by SHP siRNAs, and overexpression of the receptors reversed the effects of their respective siRNAs. SHP siRNAs also drastically enhanced the ability of the LRH-1 agonist RJW100 to induce miR-200c and downregulate ZEB1 and ZEB2 proteins. Co-expression of PPAR{alpha} and LRH-1 moderately transactivated the miR-200c promoter, which was repressed by SHP co-expression. RJW100 caused strong activation of the miR-200c promoter. This is the first report to demonstrate that miR-200c expression is controlled by nuclear receptors.

  9. Structural and functional analyses of the DMC1-M200V polymorphism found in the human population

    OpenAIRE

    Hikiba, Juri; Hirota, Kouji; Kagawa, Waturu; Ikawa, Shukuko; Kinebuchi, Takashi; Sakane, Isao; Takizawa, Yoshimasa; Yokoyama, Shigeyuki; Mandon Pepin, Béatrice; Nicolas, Alain; Shibata, Takehiko; Ohta, Kunihiro; Kurumizaka, Hitoshi

    2008-01-01

    The M200V polymorphism of the human DMC1 protein, which is an essential, meiosis-specific DNA recombinase, was found in an infertile patient, raising the question of whether this homozygous human DMC1-M200V polymorphism may cause infertility by affecting the function of the human DMC1 protein. In the present study, we determined the crystal structure of the human DMC1-M200V variant in the octameric-ring form. Biochemical analyses revealed that the human DMC1-M200V variant had reduced stabilit...

  10. Biologie 200. French Immersion Program and Franco-Manitoban Schools. Manitoba Science Assessment 1992. Final Report = Biologie 200. Programme d'immersion francaise et ecoles franco-manitobaines. Evaluation en sciences Manitoba 1992. Rapport final.

    Science.gov (United States)

    Manitoba Dept. of Education and Training, Winnipeg. Curriculum Services Branch.

    This report describes the June 1992 assessment of the Biologie 200 curriculum in schools in Manitoba, Canada. It contains a description and analysis of the test results and the teacher survey. The report also includes recommendations on ways to improve the Biologie 200 curriculum and how it is taught in the French Immersion program and…

  11. Importance of CD200 expression by tumor or host cells to regulation of immunotherapy in a mouse breast cancer model.

    Science.gov (United States)

    Curry, Anna; Khatri, Ismat; Kos, Olha; Zhu, Fang; Gorczynski, Reginald

    2017-01-01

    Cell-surface CD200 expression by mouse EMT6 breast tumor cells increased primary tumor growth and metastasis to the draining lymph nodes (DLN) in normal (WT) BALB/c female recipients, while lack of CD200R1 expression in a CD200R1-/- host negated this effect. Silencing CD200 expression in EMT6siCD200 tumor cells also reduced their ability to grow and metastasize in WT animals. The cellular mechanisms responsible for these effects have not been studied in detail. We report characterization of tumor infiltrating (TILs) and draining lymph node (DLN) cells in WT and CD200-/- BALB/c mice, receiving WT tumor cells, or EMT6 lacking CD200 expression (EMT6siCD200 cells). Our data show an important correlation with augmented CD8+ cytotoxic T cells and resistance to tumor growth in mice lacking exposure (on either host cells or tumor) to the immunoregulatory molecule CD200. Confirmation of the importance of such CD8+ cells came from monitoring tumor growth and characterization of the TILs and DLN cells in WT mice challenged with EMT6 and EMT6siCD200 tumors and treated with CD8 and CD4 depleting antibodies. Finally, we have assessed the mechanisms(s) whereby addition of metformin as an augmenting chemotherapeutic agent in CD200-/- animals given EMT6 tumors and treated with a previously established immunotherapy regime can increase host resistance. Our data support the hypothesis that increased autophagy in the presence of metformin increases CD8+ responses and tumor resistance, an effect attenuated by the autophagy inhibitor verteporfin.

  12. Importance of CD200 expression by tumor or host cells to regulation of immunotherapy in a mouse breast cancer model.

    Directory of Open Access Journals (Sweden)

    Anna Curry

    Full Text Available Cell-surface CD200 expression by mouse EMT6 breast tumor cells increased primary tumor growth and metastasis to the draining lymph nodes (DLN in normal (WT BALB/c female recipients, while lack of CD200R1 expression in a CD200R1-/- host negated this effect. Silencing CD200 expression in EMT6siCD200 tumor cells also reduced their ability to grow and metastasize in WT animals. The cellular mechanisms responsible for these effects have not been studied in detail. We report characterization of tumor infiltrating (TILs and draining lymph node (DLN cells in WT and CD200-/- BALB/c mice, receiving WT tumor cells, or EMT6 lacking CD200 expression (EMT6siCD200 cells. Our data show an important correlation with augmented CD8+ cytotoxic T cells and resistance to tumor growth in mice lacking exposure (on either host cells or tumor to the immunoregulatory molecule CD200. Confirmation of the importance of such CD8+ cells came from monitoring tumor growth and characterization of the TILs and DLN cells in WT mice challenged with EMT6 and EMT6siCD200 tumors and treated with CD8 and CD4 depleting antibodies. Finally, we have assessed the mechanisms(s whereby addition of metformin as an augmenting chemotherapeutic agent in CD200-/- animals given EMT6 tumors and treated with a previously established immunotherapy regime can increase host resistance. Our data support the hypothesis that increased autophagy in the presence of metformin increases CD8+ responses and tumor resistance, an effect attenuated by the autophagy inhibitor verteporfin.

  13. Phenomenology and research for squarks at LEP200 with the DELPHI detector; Phenomenologie et recherche de squarks a LEP200 avec le detecteur delphi

    Energy Technology Data Exchange (ETDEWEB)

    Gris, Ph. [CEA Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l`Instrumentation Associee]|[Paris-6 Univ., 75 (France)

    1998-05-01

    This thesis is devoted to the study of some supersymmetric quarks such as s-top and s-bottom. This investigation field is all the more interesting since the weak mass of these squarks could be explained by the strong Yukawa coupling between top and bottom quarks. The theoretical framework is defined and the insufficiency of the standard model is highlighted. Different models such as MSSM, supergravity models in which supersymmetry is a global symmetry are described. Squark phenomenology at LEP200 is exposed and the most likely disintegration channels for stop and s-bottom quarks are investigated in various models (MSSM, mSUGRA, supergravity models with light gravitino). The experimental tool used in this work, DELPHI detector is presented, the main elements involved in the search for squarks are precisely described. The last part of this thesis is dedicated to the effective search for squarks, the analysis deals with the energies: {radical}s=161, 172 and 183 GeV for which the luminosity values collected by DELPHI are respectively 9.7, 10 and 54 pb{sup -1}. The results are interpreted within the frameworks of different supersymmetric theories 184 refs.

  14. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation.

    Science.gov (United States)

    Cao, Huojun; Jheon, Andrew; Li, Xiao; Sun, Zhao; Wang, Jianbo; Florez, Sergio; Zhang, Zichao; McManus, Michael T; Klein, Ophir D; Amendt, Brad A

    2013-08-01

    The mouse incisor is a remarkable tooth that grows throughout the animal's lifetime. This continuous renewal is fueled by adult epithelial stem cells that give rise to ameloblasts, which generate enamel, and little is known about the function of microRNAs in this process. Here, we describe the role of a novel Pitx2:miR-200c/141:noggin regulatory pathway in dental epithelial cell differentiation. miR-200c repressed noggin, an antagonist of Bmp signaling. Pitx2 expression caused an upregulation of miR-200c and chromatin immunoprecipitation assays revealed endogenous Pitx2 binding to the miR-200c/141 promoter. A positive-feedback loop was discovered between miR-200c and Bmp signaling. miR-200c/141 induced expression of E-cadherin and the dental epithelial cell differentiation marker amelogenin. In addition, miR-203 expression was activated by endogenous Pitx2 and targeted the Bmp antagonist Bmper to further regulate Bmp signaling. miR-200c/141 knockout mice showed defects in enamel formation, with decreased E-cadherin and amelogenin expression and increased noggin expression. Our in vivo and in vitro studies reveal a multistep transcriptional program involving the Pitx2:miR-200c/141:noggin regulatory pathway that is important in epithelial cell differentiation and tooth development.

  15. 75 FR 76015 - Compliance Policy Guide Sec. 393.200 Laser(s) as Medical Devices for Facelift, Wrinkle Removal...

    Science.gov (United States)

    2010-12-07

    ... HUMAN SERVICES Food and Drug Administration Compliance Policy Guide Sec. 393.200 Laser(s) as Medical... AGENCY: Food and Drug Administration, HHS. ACTION: Notice; withdrawal. SUMMARY: The Food and Drug Administration (FDA) is announcing the withdrawal of Compliance Policy Guide Sec. 393.200 Laser(s) as Medical...

  16. 17 CFR 200.408 - Public access to transcripts and minutes of closed Commission meetings; record retention.

    Science.gov (United States)

    2010-04-01

    ... § 200.402 or otherwise. Copies of such transcript, or minutes, or a transcription of such recording..., as set forth in § 200.80e, and, if a transcript is prepared, the actual cost of such transcription... retain a complete verbatim copy of the transcript, or a complete copy of the minutes, or a complete...

  17. 75 FR 3901 - Announcement of IS-GPS-200E Interface Control Working Group (ICWG) Teleconference Meeting

    Science.gov (United States)

    2010-01-25

    ... Department of the Air Force Announcement of IS-GPS-200E Interface Control Working Group (ICWG) Teleconference... notice informs the public that the Global Positioning Systems Wing will be hosting an Interface Control Working Group (ICWG) teleconference meeting for the document IS-GPS-200E (NAVSTAR GPS Space Segment...

  18. Light Fractionation Significantly Increases the Efficacy of Photodynamic Therapy Using BF-200 ALA in Normal Mouse Skin.

    NARCIS (Netherlands)

    H.S. de Bruijn (Riette); S. Brooks (Sander); A. van der Ploeg-van den Heuvel (Angélique); T.L.M. ten Hagen (Timo); E.R.M. de Haas (Ellen); D.J. Robinson (Dominic)

    2016-01-01

    markdownabstractBACKGROUND: Light fractionation significantly increases the efficacy of 5-aminolevulinic acid (ALA) based photodynamic therapy (PDT) using the nano-emulsion based gel formulation BF-200. PDT using BF-200 ALA has recently been clinically approved and is under investigation in several

  19. miR-200c regulates FGFR-dependent epithelial proliferation via Vldlr during submandibular gland branching morphogenesis

    Science.gov (United States)

    Rebustini, Ivan T.; Hayashi, Toru; Reynolds, Andrew D.; Dillard, Melvin L.; Carpenter, Ellen M.; Hoffman, Matthew P.

    2012-01-01

    The regulation of epithelial proliferation during organ morphogenesis is crucial for normal development, as dysregulation is associated with tumor formation. Non-coding microRNAs (miRNAs), such as miR-200c, are post-transcriptional regulators of genes involved in cancer. However, the role of miR-200c during normal development is unknown. We screened miRNAs expressed in the mouse developing submandibular gland (SMG) and found that miR-200c accumulates in the epithelial end buds. Using both loss- and gain-of-function, we demonstrated that miR-200c reduces epithelial proliferation during SMG morphogenesis. To identify the mechanism, we predicted miR-200c target genes and confirmed their expression during SMG development. We discovered that miR-200c targets the very low density lipoprotein receptor (Vldlr) and its ligand reelin, which unexpectedly regulate FGFR-dependent epithelial proliferation. Thus, we demonstrate that miR-200c influences FGFR-mediated epithelial proliferation during branching morphogenesis via a Vldlr-dependent mechanism. miR-200c and Vldlr may be novel targets for controlling epithelial morphogenesis during glandular repair or regeneration. PMID:22115756

  20. 17 CFR 200.30-13 - Delegation of authority to Associate Executive Director of the Office of Financial Management.

    Science.gov (United States)

    2010-04-01

    ... Associate Executive Director of the Office of Financial Management. 200.30-13 Section 200.30-13 Commodity... authority to Associate Executive Director of the Office of Financial Management. Pursuant to the provisions... Financial Management, to be performed by him or her, or under his or her direction by such person or persons...