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Sample records for astatine 198

  1. Organic chemistry of astatine

    International Nuclear Information System (INIS)

    The paper surveys the investigations on the chemical behaviour of astatine in organic systems and deals with the preparation and identification of its organic compounds. A discussion is given on some of the physico-chemical properties of these compounds determined by extrapolation techniques as well as by direct measurement. The biomedical importance of 211At-labelled compounds is briefly referred to. (authors)

  2. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  3. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. Comment: 198 [Taxonomy Icon

    Lifescience Database Archive (English)

    Full Text Available ゲノム比較解析のためにゲノム解読が行われた。 撮影:成瀬清(基礎生物学研究所) Photo: Kiyoshi Naruse (National Institute for Basic Biology) bando 2009/10/01 14:48:45 2010/01/14 20:09:26 ... ...nal Institute for Basic Biology) licensed under CC Attribution2.1 Japan メダカ近交系 HNI-Ⅱ系統 北日本集団由来の純系。 Hd-rR系統との...Japanese medaka Oryzias latipes Oryzias_latipes_L.png 198.png Kiyoshi Naruse (Natio

  6. Dosimetrical considerations in astatine-211 radioimmunotherapy

    International Nuclear Information System (INIS)

    Several dosimetrical quantities have been suggested for use in alpha-particle dosimetry. To evaluate the expected biological effect when using these quantities, a Monte Carlo program was set to register the single-event distribution of both specific energy and alpha-particle track length to a cell nucleus (r=5.6 μm). Distributions were acquired for both 'bound' (simulating the effect of 211At-labelled antibodies bound to antigens on cell surfaces (r=7.0 μm)) as well as 'non-bound' (simulating 211At-labelled antibodies that have not bound to a cell) astatine-211. From these distributions, various theoretical cell survival curves were established for 3 different dosimetrical quantities, i.e. specific energy, number of alpha-particle hits and total track length. The survival curves for all quantities are presented for the corresponding mean absorbed dose in order to facilitate comparisons of the expected effects of using the 3 different quantities for both distributions of 211At decays. The theoretical survival curves presented here could, combined with experiments using 'bound' and 'non-bound' 211At in a single-cell suspension, reveal which dosimetrical quantity is most suitable for 211 At-radioimmunotherapy. (author)

  7. Discovery of the astatine, radon, francium, and radium isotopes

    OpenAIRE

    Fry, C; Thoennessen, M

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  8. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  9. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  10. Scrutinizing "Invisible" astatine: A challenge for modern density functionals.

    Science.gov (United States)

    Sergentu, Dumitru-Claudiu; David, Grégoire; Montavon, Gilles; Maurice, Rémi; Galland, Nicolas

    2016-06-01

    The main-group 6p elements did not receive much attention in the development of recent density functionals. In many cases it is still difficult to choose among the modern ones a relevant functional for various applications. Here, we illustrate the case of astatine species (At, Z = 85) and we report the first, and quite complete, benchmark study on several properties concerning such species. Insights on geometries, transition energies and thermodynamic properties of a set of 19 astatine species, for which reference experimental or theoretical data has been reported, are obtained with relativistic (two-component) density functional theory calculations. An extensive set of widely used functionals is employed. The hybrid meta-generalized gradient approximation (meta-GGA) PW6B95 functional is overall the best choice. It is worth noting that the range-separated HSE06 functional as well as the old and very popular B3LYP and PBE0 hybrid-GGAs appear to perform quite well too. Moreover, we found that astatine chemistry in solution can accurately be predicted using implicit solvent models, provided that specific parameters are used to build At cavities. © 2016 Wiley Periodicals, Inc. PMID:27059181

  11. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  12. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  13. 7 CFR 800.198 - Contracts.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Contracts. 800.198 Section 800.198 Agriculture..., Designations, Approvals, Contracts, and Conflicts of Interest § 800.198 Contracts. (a) Services contracted and who may apply. The Service may enter into a contract with any person, State, or governmental agency...

  14. Astatine-211: production, injection into monoclonal antibodies radiological effect, possible application to cancer treatment

    International Nuclear Information System (INIS)

    Methods developed in the Laboratory of Nuclear Problems, JINR, for producing astatine-211 and injecting it into monoclonal antibodies are described. The use of its diethylene triamine penta-acetic acid complex is shown to be the most effective method of injecting astatine into a biomolecules. The biological effect of the α-particles emitted from the astatine-211 is investigated using Chinese hamster fibroblasts and Ehrlich carcinoma cells. It is established that the mitotic activity depression, number of degenerating cells, number of cells with chromosome aberrations, and cellular surviving fraction depend on the concentration of the radionuclide in the medium 'in vitro'. The RBE of α-particles in comparison with 60Co γ-rays is 3. Injection of astatine-211 absorbed on tellurium particles into mice with ascitic tumors resulted in prolongation of their life or elimination of the tumors. (author). 39 refs, 7 figs

  15. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  16. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    Science.gov (United States)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-07-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method that combines dry distillation of astatine-211 and a synthesis module for producing radiopharmaceuticals into a process platform. This platform will standardize production of astatinated radiopharmaceuticals, and hence, it will facilitate large clinical studies focused on this promising, but chemically challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies.

  17. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-01-01

    vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method......To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and...... challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies....

  18. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  19. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  20. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  1. On the production of colloidal gold-198

    International Nuclear Information System (INIS)

    Colloidal gold-198 locally produced by the Noratom procedure which represents one-step method is compared with the product of another procedure which represents a two-step method. Quality control of the product of the two methods was carried out for ionic gold content, particle size and biological distribution in mice. The one-step method product proved to be better for liver scanning than that of the other procedure under the experimental conditions used. (author)

  2. 49 CFR 198.13 - Grant allocation formula.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Grant allocation formula. 198.13 Section 198.13... PIPELINE SAFETY PROGRAMS Grant Allocation § 198.13 Grant allocation formula. (a) Beginning in calendar year... state agency comments on any proposed changes to the allocation formula. (f) Grants are limited to...

  3. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  4. Direct astatination of a tumour-binding protein, human epidermal growth factor, using nido-carborane as a prosthetic group

    International Nuclear Information System (INIS)

    A method for direct astatine labeling of proteins has been investigated. Binding sites for astatine were created by coupling of a nido-carborane derivative to a protein, the human epidermal growth factor (hEGF), using two different conjugation methods - by glutaraldehyde cross-linking or by introduction of sulfohydryl groups by Traut's reagent with subsequent linking of ANC-1 with m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester. The conjugates were astatinated using the Chloramine-T method in high yield. The best labeling was obtained by the glutaraldehyde conjugate with an average yield of 68 ± 9%. In vitro stability tests indicated that the glutaraldehyde conjugated label was as stable as hEGF labeled with astatobenzoate. (author)

  5. A submillimeter protostar mear LkH-alpha 198

    Science.gov (United States)

    Sandell, Goran; Weintraub, David A.

    1994-01-01

    We present submillimeter and millimeter line and continuum observations of the region around LkH-alpha 198 and V376 Cas. The continuum data reveal the presence of a very cool object, LkH-alpha 198 MM located approximately 19 sec northwest of LkH-alpha 198. LkH-alpha 198 MM is not visible in the near-IR. The CO maps suggest that the mm-source, rather than LkH-alpha 198 or its IR companion LkH-alpha 198B, may drive the large CO outflow seen in this cloud or that both drive outflows which are roughly aligned with each other. In addition V376 Cas appears to power a small bipolar CO outflow.

  6. Production of radio-isotopes 197Hg and 198Au from 198Hg

    International Nuclear Information System (INIS)

    Studies on excitation functions of neutron induced reactions are of considerable importance for testing nuclear models as well as for practical applications. Mercury can be a suitable material for spallation neutron source in an accelerator driven system (ADS) if corrosion, due to chemical wetting, gradient mass transfer, and high density heat generation are taken care of. In order to design the target system, estimation of induced activity in the target is important among other factors. In an ADS this radioactivity is induced by neutrons along with that by the primary projectile. An ADS is operated at a few GeV beam energy, but often logistic studies are carried out at much lower energies. Quantitative knowledge of the induced activity at such operating parameters is important for proper planning of the experiments. The aim of the present work is to determine the excitation functions of 198Hg (n, 2n) 197Hg and 198Hg (n, p) 198Au reactions for 1-50 MeV energy using statistical and pre-equilibrium nuclear reaction model codes. This will help us to determine the total yield and induced activities due to these radio nuclides. The computed excitation functions are compared with and the reported measured data and cross sections from ENDF database

  7. Labelling prospects of astatine-211 with immunoglobulins (IgG): some general considerations

    International Nuclear Information System (INIS)

    The tumour therapeutic potential of the short lived alpha emitting radiohalogen 211At has been already been well recognised in the field of radioimmuno therapy. There is no evidence as such to show that astatine itself is a tumour seeking isotope. Therefore it has to be tagged to tumour seeking compound such as a drug or a protein preferably an antibody (IgG). In this communication, the labelling parameters which are required to be investigated for obtaining a stable product which could be useful as radioimmuno therapeutic agent, are described. (author). 6 refs

  8. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  9. Extraction of 211At-astatine from hydrochloric acid solutions by means of TOPO, TBP, and triphenylphosphine

    International Nuclear Information System (INIS)

    The extraction behaviour of astatine was studied under defined conditions from hydrochloride acid solutions (cHCl>0.1 M or 1 and 2M). Therefore other effects like adsorption, reduction or hydrolysis can be excluded. The present work describes the extraction with tri- n- octylphosphinoxide (TOPO), tri- n-butylphosphate (TBP) and tri-phenylphosphine in chloroform. (orig.)

  10. No-carrier-added astatination of N-succinimidyl-3-(tri-n-butylstannyl) benzoate (ATE) via electrophilic destannylation

    International Nuclear Information System (INIS)

    The no-carrier-added synthesis of N-succinimidyl 3-[211At]astato-benzoate from N-succinimidyl 3-(tri-n-butylstannyl)benzoate (ATE) is described. The nature of the solvent in which the 211At was isolated from the target was an important factor influencing both the radiochemical yields and the nature of the incorporated astatine activity. (orig.)

  11. 30 CFR 19.8 - Protection against bodily hazard.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection against bodily hazard. 19.8 Section..., AND APPROVAL OF MINING PRODUCTS ELECTRIC CAP LAMPS § 19.8 Protection against bodily hazard. This hazard is chiefly due to the possible burning of the wearer by electrolyte spilled from the battery....

  12. 19 CFR 10.198 - Evidence of country of origin.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Evidence of country of origin. 10.198 Section 10... § 10.198 Evidence of country of origin. (a) Shipments covered by a formal entry—(1) Articles not wholly... informal entry, the port director may require such other evidence of country of origin as deemed...

  13. 211At-Rh(16-S4-diol) complex as a precursor for astatine radiopharmaceuticals

    International Nuclear Information System (INIS)

    211At is one of the most promising radionuclides in α-radioimmunotherapy (α-RIT). Unfortunately, biomolecules labeled by direct electrophilic astatination are unstable due to the rapid loss of 211At under both in vitro and in vivo conditions. The present paper describes the results of our studies on attaching At- to the rhodium(III) complex with thioether ligand: 1,5,9,13-etrathiacyclohexadecane-3,11-diol (16-S4-diol). Rh3+ was chosen as a moderately soft metal cation which should form very strong bonds with soft At- anions, but first of all because of the kinetic inertness of low spin rhodium(III) d6 complexes. The 16-S4-diol ligand was selected due to formation of stable complexes with Rh3+. The experiments related to optimization of the reaction conditions were performed with the 131I, basing on a chemical similarity of I- to At-. The experiments with 211At were then carried out under the conditions found optimal for I-. The preliminary results are promising, and indicate a possibility for astatination of biomolecules by using the 211At-Rh(16-S4-diol) complex

  14. Optimization of the Parameters Affecting the Fenton Process for Decolorization of Reactive Red 198 (RR-198) from the Aqueous Phase

    OpenAIRE

    Mansooreh Dehghani; Mahshid Ghadami; Talat Gholami; Marzieh Ansari Shiri; Zahra Elhameyan; Mohammad Reza Javaheri; Narges Shamsedini; Samaneh Shahsavani

    2015-01-01

    Background: Recently, there has been a great concern about the consumption of dyes because of their toxicity, mutagenicity, carcinogenicity, and persistence in the aquatic environment. Reactive dyes are widely used in textile industry. Advanced oxidation processes are one of the cost-effective methods for the removal of these dyes. The main aims of this study were determining the feasibility of using Fenton process in removing Reactive Red 198 (RR-198) dye from aqueous so...

  15. 儿童糖尿病198例%Diabetes Mellitus in 198 Children

    Institute of Scientific and Technical Information of China (English)

    张文; 刘丽; 李秀珍; 黄永兰; 程静

    2011-01-01

    Objective To investigate the clinical characteristics and provide theoretic basis of diabetes mellitus( DM) for the diagnosis and treatment. Methods The clinical manifestation and laboratory examination of 198 children with DM from Jan. 1999 to Mar. 2009 in Guangzhou Women and Children's Medical Center were analyzed retrospectively. Results Among total 198 new cases of children with DM, there were 97 boys and 101 girls;the onset peak age was 5 to 6 years old and 9 to 11 years old;new cases were increasing year by year and cases of 2008 were 3.7 times than those of 1999; Among 198 new cases, 174(88. 9%) cases with type 1 diabetes mellitus( T1DM) ,7 (3. 5% ) cases with type 2 diabetes mellitus, 14(7.1% ) cases with neonatal DM and 3(1.5% ) case with other types. Among the new cases with T1DM,the incidence of diabetic ketoacidosis(DKA) was 42.1% ;55 cases had infection history before the onset of disease;the incidence of DKA had significant difference Between the infection group and the non - infection group (P <0. 01) ;23 cases had family history. Two caseswith hyperthyroidism,31 cases with temporary hypothyroidism,30 cases with liver function damage, 12 cases with kidney function damage ,48 cases with dislipidemia,27 cases with proteinuria;the average HbAlc was (12.0 ±1.8)% ,the positive rate of islet cells antibodies in 25 cases of T1DM was 28% ,the positive rate of insulin auto - antibody was 20% and the positive rate of glutamic acid decarboxylase antibody (GADA) was 72% . Conclusions New cases with DM are increasing year by year and most cases are Tl DM; cases with neonatal diabetes increase significantly; DKA is the important reason of children with T1DM going to hospital and infections is the important incentive of DKA;children with DM has also temporary hypothyroidism,liver function damage,kidney function damage and dislipidemia;the positive rate of GADA is the highest in autoimmune antibodies.%目的 探讨儿童糖尿病(DM)的临床特点,为临床

  16. ISO-PC Version 1.98: User's guide

    International Nuclear Information System (INIS)

    This document describes how to use Version 1.98 of the shielding program named ISO-PC. Version 1.98 corrects all known errors in ISOSHLD-II. In addition, a few numeric problems have been eliminated. There are three new namelist variables, 25 additional shielding materials, and 5 more energy groups. The two major differences with the original ISOSHLD-II are the removal of RIBD(radioisotope buildup and decay) source generator, and the removal of the non-uniform source distribution parameter, SSV1. This version of ISO-PC works with photon energies from 10 KeV to 10 MeV using 30 energy groups

  17. Tritium stripping in a nitrogen glovebox using SAES St 198

    International Nuclear Information System (INIS)

    SAES metal getter material St 198 was chosen for glovebox stripper tests to evaluate its effectiveness of removing tritium from a nitrogen atmosphere. The St 198 material is unique from a number of other metal hydride-based getter materials in that it is relatively inert to nitrogen and can thus be used in nitrogen glovebox atmospheres. Six tritium stripper experiments which mock-up the use of a SAES St 198 stripper bed for a full-scale (10,500 liter) nitrogen glovebox have been completed. Experiments consisted of a release of small quantity of protium/deuterium spiked with tritium which were scaled to simulate tritium releases of 0.1 g., 1.0 g., and 10 g. into the glovebox. The tritium spike allows detection using tritium ion chambers. The St 198 stripper system produced a reduction in tritium activity of approximately two orders of magnitude in 24 hours (6--8 atmosphere turn-overs) of stripper operation

  18. 14 CFR 198.3 - Basis of insurance.

    Science.gov (United States)

    2010-01-01

    ... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) WAR RISK INSURANCE AVIATION INSURANCE § 198.3 Basis of insurance. (a) Premium insurance may be issued by the FAA is... without premium may be issued by the FAA if all of the following conditions have been met: (1)...

  19. 14 CFR 198.9 - Applicant for insurance.

    Science.gov (United States)

    2010-01-01

    ...) WAR RISK INSURANCE AVIATION INSURANCE § 198.9 Applicant for insurance. (a) Application for premium or non-premium insurance must be made in accordance with the applicable form supplied by the FAA. (b) Each applicant for insurance with the premium under this part must submit to the FAA with...

  20. 14 CFR 198.7 - Amount of insurance coverage available.

    Science.gov (United States)

    2010-01-01

    ... (CONTINUED) WAR RISK INSURANCE AVIATION INSURANCE § 198.7 Amount of insurance coverage available. (a) For... arising from any risk. In the case of hull insurance, the amount insured may not exceed the reasonable... premium may be revised from time to time by the FAA with notice to the insured, to add aircraft...

  1. Intrathecal therapy with 198Au-colloid for meningosis prophylaxis

    International Nuclear Information System (INIS)

    Telecobalt irradiation in combination with intrathecal (IT) methotrexate has been replaced by IT 198Au-colloid and methotrexate for meningosis prophylaxis in leukemia. Seventy-seven children received 56-200 MBq 198Au-colloid. The distribution was measured with a scintillation camera having a data processing facility. The radiopharmaceutical is adsorbed at the surface of the spaces with cerebrospinal fluid (CSF) 10-20 h after application. The normal retention of the administered radioactivity in the intracranial subarachnoid space (ISS) and in the spinal subarachnoid space (SSS) were 52+-10% and 26+-9%, respectively. An impairment of the normal distribution was observed after IT methotrexate because of postinjection CSF leakage. The calculated readiation absorbed doses in the cerebral and spinal meninges at a depth of 0.01 cm, i.e. the thickness of the pia, were 45+-17 mGy and 189+-91 mGy, respectively, for 1 MBq administered 198Au-colloid. The dosimetry shows that an effective radiation absorbed dose of 18 Gy can be delivered to the cerebral meninges by the application of 400 MBq 198Au-colloid. (orig.)

  2. 40 CFR 180.198 - Trichlorfon; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Trichlorfon; tolerances for residues...) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.198 Trichlorfon; tolerances for residues. (a) General. Tolerances are established for residues...

  3. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  4. Optimization of the Parameters Affecting the Fenton Process for Decolorization of Reactive Red 198 (RR-198 from the Aqueous Phase

    Directory of Open Access Journals (Sweden)

    Mansooreh Dehghani

    2015-10-01

    Full Text Available Background: Recently, there has been a great concern about the consumption of dyes because of their toxicity, mutagenicity, carcinogenicity, and persistence in the aquatic environment. Reactive dyes are widely used in textile industry. Advanced oxidation processes are one of the cost-effective methods for the removal of these dyes. The main aims of this study were determining the feasibility of using Fenton process in removing Reactive Red 198 (RR-198 dye from aqueous solution and determining the optimal conditions. Methods: This is a cross-sectional study conducted at a laboratory scale. A total of 69 samples were considered and the effect of pH, Fe (II concentration, H2O2 concentration, initial dye concentration and reaction time were investigated. Results: According to the results, a maximum removal efficiency of 92% was obtained at pH of 3 and the reaction time of 90 min; also, the concentration of Fe (II, H2O2, initial dye concentration were 100 mg/L, 50 mg/L, and 100 mg/L, respectively. The results revealed that by increasing the concentration of Fe (II, H2O2 and initial dye, the removal efficiency was increased. Conclusions: The results showed that Fenton process could be used as a cost-effective method for removing RR-198 dye from textile wastewater efficiently.

  5. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  6. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  7. 43 CFR 19.8 - Prospecting, mineral locations, mineral patents, and mineral leasing within National Forest...

    Science.gov (United States)

    2010-10-01

    .... 2 of 43 CFR, which appears in Volume II of the List of CFR Sections Affected, 1964-1972, for the... patents, and mineral leasing within National Forest Wilderness. 19.8 Section 19.8 Public Lands: Interior... § 19.8 Prospecting, mineral locations, mineral patents, and mineral leasing within National...

  8. 42 CFR 413.198 - Recordkeeping and cost reporting requirements for outpatient maintenance dialysis.

    Science.gov (United States)

    2010-10-01

    ... outpatient maintenance dialysis. 413.198 Section 413.198 Public Health CENTERS FOR MEDICARE & MEDICAID... § 413.198 Recordkeeping and cost reporting requirements for outpatient maintenance dialysis. (a) Purpose... will enable CMS to determine the costs incurred in furnishing outpatient maintenance dialysis...

  9. 49 CFR 198.35 - Grants conditioned on adoption of one-call damage prevention program.

    Science.gov (United States)

    2010-10-01

    ... prevention program. 198.35 Section 198.35 Transportation Other Regulations Relating to Transportation... Prevention Program § 198.35 Grants conditioned on adoption of one-call damage prevention program. In... considers whether a State has adopted or is seeking to adopt a one-call damage prevention program...

  10. Collective oblate dipole rotational bands in [sup 198]Pb

    Energy Technology Data Exchange (ETDEWEB)

    Clark, R.M. (Department of Physics, University of York (United Kingdom)); Wadsworth, R. (Department of Physics, University of York (United Kingdom)); Paul, E.S. (Oliver Lodge Lab., University of Liverpool (United Kingdom)); Beausang, C.W. (Oliver Lodge Lab., University of Liverpool (United Kingdom)); Ali, I. (Oliver Lodge Lab., University of Liverpool (United Kingdom)); Astier, A. (Institut de Physique Nucleaire de Lyon, IN2P3-CNRS/Universite Claude Bernard, 69 - Villeurbanne (France)); Cullen, D.M. (Oliver Lodge Lab., University of Liverpool (United Kingdom)); Dagnall, P.J. (Oliver Lodge Lab., University of Liverpool (United Kingdom)); Fallon, P. (Oliver Lodge Lab., University of Liverpool (United Kingdom)); Joyce, M.J. (Oliver Lodge Lab., University of Liverpool (United Kingdom)); Meyer, M. (Institut de Physique Nucleaire de Lyon, IN2P3-CNRS/Universite Claude Bernard, 69 - Villeurbanne (France)); Redon, N. (Institut de Physique Nucleaire de Lyon, IN2P3-CNRS/Universite Clau

    1993-09-13

    The nucleus [sup 198]Pb was populated via the [sup 186]W([sup 17]O, 5n)[sup 198]Pb reaction at beam energies of 92 and 98 MeV. Five collective rotational cascades of [Delta]I=1 transitions have been found. Four are highly regular, one much more irregular. The structures are incorporated into a level scheme which extends up to approximately spin 32 h and an excitation energy of about 10 MeV. Angular correlation measurements confirm the dipole character of the interband transitions. Their M1 multipolarity is inferred, and from this supposition the experimental data are interpreted in terms of oblate high-K two quasiproton configurations coupled to aligned neutron excitations. This interpretation is extended to include other [Delta]I=1 oblate structures observed in [sup 194-201]Pb. It is shown that the pattern of observed moments of inertia can be understood in the simple unpaired picture involving neutron i[sub 13/2] excitations. The identical bands observed are interpreted in terms of the normal-parity weakly-coupled singlet orbital. (orig.)

  11. Collective oblate dipole rotational bands in 198Pb

    International Nuclear Information System (INIS)

    The nucleus 198Pb was populated via the 186W(17O, 5n)198Pb reaction at beam energies of 92 and 98 MeV. Five collective rotational cascades of ΔI=1 transitions have been found. Four are highly regular, one much more irregular. The structures are incorporated into a level scheme which extends up to approximately spin 32 h and an excitation energy of about 10 MeV. Angular correlation measurements confirm the dipole character of the interband transitions. Their M1 multipolarity is inferred, and from this supposition the experimental data are interpreted in terms of oblate high-K two quasiproton configurations coupled to aligned neutron excitations. This interpretation is extended to include other ΔI=1 oblate structures observed in 194-201Pb. It is shown that the pattern of observed moments of inertia can be understood in the simple unpaired picture involving neutron i13/2 excitations. The identical bands observed are interpreted in terms of the normal-parity weakly-coupled singlet orbital. (orig.)

  12. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  13. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  14. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  15. Application of 198Au grains for carcinoma of oral cavity

    International Nuclear Information System (INIS)

    The purpose of this study is to analyze the results of the treatment using gold grain implants over the past 9 years and to evaluate the usefulness of this treatment method. From January 1985 through April 1993, a total of 45 patients with squamous cell carcinomas of the oral cavity and the oropharynx were treated with 198Au grain (gold grain) at the Department of Radiology, Osaka University Medical School. The initial activity of the grains supplied weekly by the Japan Radioisotope Association was usually 5 mCi (185 MBq), and single implants were usual. In case of combined external irradiation, telecobalt γ-rays or 4 MV X-rays were used for treatment before implant. The local control rate for patients with T1 stages was 80% (20/25) and with T2 stages, 59% (10/17). The local control rate was 71% (10/14) for gold grain alone and 72% (13/18) for external irradiation combined with gold grain implants (combined therapy). In combined therapy, the median of the interval between external irradiation and gold grain implants was 21 days. The treatment interval or patients with recurrent diseases was 22 days, 22, 27, 39 and 46, respectively. The progression rate showed a tendency to increase in the patients with longer interval (more than 21 days), and with partial regression after external irradiation and gold grain implantation is an important factor in combined therapy. Therefore, we emphasize that the time interval should be shorter than 3 weeks. (orig.)

  16. The kinetics of phagocytosis of 198Au colloids ''in vitro''

    International Nuclear Information System (INIS)

    The kinetics of the phagocytosis of 198-Au colloids by macrophages ''in vitro'' was studied by incubating during 5 hours phagocytic cells from the liver and the spleen of Wistar rats with colloidal radiogold particles, in the presence of an adequate culture medium (TC-199 with 10 per cent of Bovine Fetal Serum). In each experiment, the number of colloidal gold particles offered to each phatocytic cell, (Au)0 and the mean rate of phagocytosis v, were calculated. The latter value was determined by measuring the radioactivity incorporated into the phagocytic cells during the incubation; it was expressed as the number of phagocytized colloidal gold particles per cell per minute. The values of log v = f [log (Au)0] were plotted. The Lineweaver-Burk analysis of the results demonstrates that the kinetics of the phagocytosis of colloidal radiogold particles ''in vitro'' follows a model similar to Michaelis-Menten equations for enzyme reactions. The values of the substratum constant Ks and maximun velocity Vm were obtained by the regression analysis of the 1/v vs. 1/(Au)0 graph. Vm was equal to 9.44 x 10 and 1.63 x 10 phagocytized colloidal gold particles per cell per minute for liver and spleen macrophages, respectively. Ks was equal to 6.01 x 109 and 8.02 x 108 colloidal gold particles per cell for liver and spleen macrophages, respectively. The significance of these differences is discussed and attributed mainly to a change of the specific engulfment rate constant. (author)

  17. 49 CFR 198.37 - State one-call damage prevention program.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false State one-call damage prevention program. 198.37... REGULATIONS FOR GRANTS TO AID STATE PIPELINE SAFETY PROGRAMS Adoption of One-Call Damage Prevention Program § 198.37 State one-call damage prevention program. A State must adopt a one-call damage...

  18. Stability and in vivo behavior of Rh[16aneS4-diol]211At complex: A potential precursor for astatine radiopharmaceuticals

    International Nuclear Information System (INIS)

    Introduction: The heavy halogen 211At is of great interest for targeted radiotherapy because it decays by the emission of short-range, high-energy α-particles. However, many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking other 211At labeling strategies. One relatively unexplored approach is to utilize prosthetic groups based on astatinated rhodium (III) complex stabilized with a tetrathioether macrocyclic ligand – Rh[16aneS4-diol]211At. The purpose of the current study was to evaluate the in vitro and in vivo stability of this complex in comparison to its iodine analog – Rh[16aneS4-diol]131I. Methods: Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I complexes were synthesized and purified by HPLC. The stability of both complexes was evaluated in vitro by incubation in phosphate-buffered saline (PBS) and human serum at different temperatures. The in vivo behavior of the two radiohalogenated complexes was assessed by a paired-label biodistribution study in normal Balb/c mice. Results: Both complexes were synthesized in high yield and purity. Almost no degradation was observed for Rh[16aneS4-diol]131I in PBS over a 72 h incubation. The astatinated analog exhibited good stability in PBS over 14 h. A slow decline in the percentage of intact complex was observed for both tracers in human serum. In the biodistribution study, retention of 211At in most tissues was higher than that of 131I at all time points, especially in spleen and lungs. Renal clearance of Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I predominated, with 84.1 ± 2.3% and 94.6 ± 0.9% of injected dose excreted via the urine at 4 h. Conclusions: The Rh[16aneS4-diol]211At complex might be useful for constructing prosthetic groups for the astatination of biomolecules and further studies are planned to evaluate this possibility

  19. Clinical evaluation of short-life radioactive source Au-198 grain

    International Nuclear Information System (INIS)

    Au-198 grain has been used as a new source in brachytherapy instead of Rn-seed since September 1975 in Japan. A total of 60 cases with malignant tumors of the oral cavity treated with Au-198 grain during the period of September 1975 to November 1978 were analyzed. Nineteen cases were treated with Au-198 grain alone, twenty-nine were with combined external beam therapy and the other twelve were treated as a boost implant for Radium needles or as a recurrent disease. Two-year local recurrence free rates were 78% (7/9) by Au-198 grain alone and 67% (10/15) by Au-198 grain combined with external beam therapy. The frequency of local necrosis following the combined therapy was inevitably higher than Au-198 grain alone. However, these results were somewhat better than the results obtained from treatment of tongue cancer using Rn seed with or without external beam which reported previously. An analysis was also made of the local condition of the treated area applying with the TDF values. A suitable permanent implant dose of Au-198 grain might be slightly lower than Rn seed considering from the TDF value analysis. The Au-198 grain technique seemed to be an excellent choice of treatment as far as the lesion was small or superficial enough, or the lesion was locating in the sites anatomically to be not able to apply Radium needles. The technique has also an advantage to be applicable without severe discomfort to the patient and less exposure to the operator compared to the Radium needle technique. (author)

  20. Gastrointestinal transit in the chicken using 198Au-colloid as a marker

    International Nuclear Information System (INIS)

    Gastrointestinal transit in the chicken was investigated by using 198Au-colloid as a marker. Gastrointestinal transit was determined following administration of a 198Au-colloid solution (370 kBq (10 μCi), 0.5 ml) into the proventriculus by measuring the distribution of radioactivity in the gastrointestine. Most of 198Au-colloid administered into the proventriculus was transfered instantly to the gizzard and subsequently, some part of it quickly to the duodenum and the upper segment of the jejunoileum. A considerable quantity of 198Au-colloid in the duodenum, the upper and middle segment of the jejunoileum regurgitated to the gizzard. 198Au-colloid transferred to the caecum was retained for a long time (more than 48 hours) in these segments. A part of 198Au-colloid was found in the feces 90 to 120 minutes after administration into the proventriculus and the greater part of it was excreted into the feces 24 to 48 hours. Subcutaneous administration of acetylcholine (2 mg/kg) increased the gastrointestinal transit but atropine (2 mg/kg) decreased. (author)

  1. Calculation of beta induced Bremsstrahlung exposure from therapeutic radionuclide 198Au in tissues, DNA and RNA

    International Nuclear Information System (INIS)

    Gold-198 (βmax= 0.96 MeV (98.6%), γmax= 0.412 MeV (95.5%) and T1/2 = 2.7 days) is a well-known therapeutic beta emitter in the field of nuclear medicine, and is being used for the treatment of many different cancers. In the present study, the Bremsstrahlung exposure induced by 198Au in different human tissues, DNA and RNA has been calculated. The specific Bremsstrahlung constant (ΓBr), Probability of energy loss by beta during Bremsstrahlung emission (PBr) and Bremsstrahlung activity (Arelease)Br were estimated. We strongly recommend these parameters should be considered in absorbed dose calculations of radionuclide therapy via 198Au. (orig.)

  2. Spectroscopy and measurement of electromagnetic moments in sup(198,200,210)Po

    International Nuclear Information System (INIS)

    The quadrupole coupling constants for the 210Po Isup(π)=8+, 11-, 13- isomers in Bi have been measured, and Q(11-)=82(2) fm2 and Q(13-)=90(2) fm2 normalized to Q(210Po8+)=57 fm2 are deduced. In beam γ-spectroscopy of sup(198,) 200Po showed the (πh2sub(9/2) 8+) π(hsub(9/2)isub(13/2) 11-) and (visub(13/2) 12+) isomers. The B(E2 8+->6+) and Q(8+) in 198Po to 210Po are discussed, a sudden drop is found for the B(E2) in 198Po. The B(E3, 11-->8+) rises very steeply in the light Po isotopes. (orig.)

  3. Thermoelectric properties of Zintl compound Ca1-xNaxMg2Bi1.98

    Science.gov (United States)

    Shuai, Jing; Kim, Hee Seok; Liu, Zihang; He, Ran; Sui, Jiehe; Ren, Zhifeng

    2016-05-01

    Motivated by good thermoelectric performance of Bi-based Zintl compounds Ca1-xYbxMg2Biy, we further studied the thermoelectric properties of Zintl compound CaMg2Bi1.98 by doping Na into Ca as Ca1-xNaxMg2Bi1.98 via mechanical alloying and hot pressing. We found that the electrical conductivity, Seebeck coefficient, power factor, and carrier concentration can be effectively adjusted by tuning the Na concentration. Transport measurement and calculations revealed that an optimal doping of 0.5 at. % Na achieved better average ZT and efficiency. The enhancement in thermoelectric performance is attributed to the increased carrier concentration and power factor. The low cost and nontoxicity of Ca1-xNaxMg2Bi1.98 makes it a potentially promising thermoelectric material for power generation in the mid-temperature range.

  4. Measurement of Colloidal Gold-198 and Phosphorus-32 Present in the Same Sample

    International Nuclear Information System (INIS)

    Colloidal 198Au and 32P are normally used separately in therapeutics. In comparative metabolism studies, however, the two colloids are sometimes administered together and hence found in the same biological sample. The simultaneous determination of the activity of each of the radioisotopes then poses a problem which the authors have attempted to solve, using the Bremsstrahlung of the 32P, by the following two methods: (1) Measurement of the 198Au and 32P after establishing their respective electromagnetic spectral curves and selecting favourable peaks; (2) Simultaneous radioactivity measurements using a photomultiplier with two distinct amplitude discrimination thresholds which give different yields for the two emissions. Both methods are evaluated with the help of standards, their validity is discussed, and the limits of their applicability are specified. The second method was employed in studying the reciprocal effects of colloidal 198Au and 32P on in vitro sedimentation in an ascitic fluid. (author)

  5. Synthesis and Characterization of Poly(Amidoamine Dendrimers Encapsulatd 198Au Nanoparticles

    Directory of Open Access Journals (Sweden)

    R. Ritawidya1,2

    2012-12-01

    Full Text Available Brachytherapy or internal radiotherapy is one of many methods used for treatment of cancer. This modality requires an agent with radionuclides that emits  or β particle with a proper energy. 198Au (99% β max = 0.96 MeV and t1/2 = 2.69 days is one of radionuclides that has been considered to be effective for the above-mentioned purpose. The purpose of this research was to synthesis and characterize poly(amidoamine (PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles as a new brachytherapy agent. PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles was successfully synthesized by a bottom-up method using sodium borohydride as a reductor. Purification was then performed by a size exclusion chromatography in order to separate large Au nanoparticles that were formed outside the cavity of PAMAM G3.0 dendrimers. Prior to the synthesis of PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles, the synthetic procedure was first established by using a non-radioactive Au. The PAMAM G3.0 dendrimers encapsulated Au nanoparticles produced was then characterized by using an UV-Vis spectroscopy, a transmission electron microscopy (TEM, particle size analyzer (PSA, and an atomic absorption spectroscopy (AAS. Characterization results revealed that PAMAM G3.0 dendrimers encapsulated Au nanoparticles that were prepared from a reaction mixture of PAMAM G3.0 dendrimers and Au HAuCl4 with mol ratio of 2.8, was found to be a proper formula. It produced PAMAM G3.0 dendrimers encapsulated Au nanoparticles with diameter of 1.743 nm, spheris, uniform and drug loading value of 26.34%. This formula was then used in synthesis using radioactive Au, 198Au. Characterization results of PAMAM G3.0 dendrimers encapsulated 198Au nanoparticles gave a radiochemical purity of 99.4% and zero charge.

  6. ISO-PC Version 1.98: User`s guide

    Energy Technology Data Exchange (ETDEWEB)

    Rittmann, P.D.

    1995-05-02

    This document describes how to use Version 1.98 of the shielding program named ISO-PC. Version 1.98 corrects all known errors in ISOSHLD-II. In addition, a few numeric problems have been eliminated. There are three new namelist variables, 25 additional shielding materials, and 5 more energy groups. The two major differences with the original ISOSHLD-II are the removal of RIBD(radioisotope buildup and decay) source generator, and the removal of the non-uniform source distribution parameter, SSV1. This version of ISO-PC works with photon energies from 10 KeV to 10 MeV using 30 energy groups.

  7. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  8. Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter

    International Nuclear Information System (INIS)

    The sodium/iodide symporter (NIS) has been recognized as an attractive target for radioiodine-mediated cancer gene therapy. In this study we investigated the role of human NIS for cellular uptake of the high LET α-emitter astatine-211 (211At) in comparison with radioiodine as a potential radionuclide for future applications. A mammalian NIS expression vector was constructed and used to generate six stable NIS-expressing cancer cell lines (three derived from thyroid carcinoma, two from colon carcinoma, one from glioblastoma). Compared with the respective control cell lines, steady state radionuclide uptake of NIS-expressing cell lines increased up to 350-fold for iodine-123 (123I), 340-fold for technetium-99m pertechnetate (99mTcO4-) and 60-fold for 211At. Cellular 211At accumulation was found to be dependent on extracellular Na+ ions and displayed a similar sensitivity towards sodium perchlorate inhibition as radioiodide and 99mTcO4- uptake. Heterologous competition with unlabelled NaI decreased NIS-mediated 211At uptake to levels of NIS-negative control cells. Following uptake both radioiodide and 211At were rapidly (apparent t1/2 3-15 min) released by the cells as determined by wash-out experiments. Data of scintigraphic tumour imaging in a xenograft nude mice model of transplanted NIS-modified thyroid cells indicated that radionuclide uptake in NIS-expressing tumours was up to 70 times (123I), 25 times (99mTcO4-) and 10 times (211At) higher than in control tumours or normal tissues except stomach (3-5 times) and thyroid gland (5-10 times). Thirty-four percent and 14% of the administered activity of 123I and 211At, respectively, was found in NIS tumours by region of interest analysis (n=2). Compared with cell culture experiments, the effective half-life in vivo was greatly prolonged (6.5 h for 123I, 5.2 h for 211At) and preliminary dosimetric calculations indicate high tumour absorbed doses (3.5 Gy/MBqtumour for 131I and 50.3 Gy/MBqtumour for 211At). In

  9. 19 CFR 10.198a - Duty reduction for certain leather-related articles.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Duty reduction for certain leather-related... Basin Initiative § 10.198a Duty reduction for certain leather-related articles. Except as otherwise..., flat goods, work gloves, and leather wearing apparel that were not designated on August 5, 1983,...

  10. Application of radioisotopes Au -198 to radiometrical field investigation of spraying machine

    Energy Technology Data Exchange (ETDEWEB)

    Goraczko, W.; Kocorowska, E. [Technical Univeristy, Poznan (Poland). Radio and Photo-Chemistry Department

    1997-10-01

    The poster shows application of radioisotope {sup 198}Au to radiometrical field testing of spraying machine. In the research was tested the Polish suspensioned tractor OZS400 type spraying machine. The machine worked in two different variants: without and with the beam stabilisation (oscillatory stabilisation)

  11. 14 CFR 121.198 - Cargo service airplanes: Increased zero fuel and landing weights.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Cargo service airplanes: Increased zero... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Airplane Performance Operating Limitations § 121.198 Cargo service airplanes: Increased zero fuel and landing...

  12. Fiscal Deficit Will Be Cut Down RMB19.8 Billion This Year

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ When delivering the government work report on March5, Premier Wen Jiabao said,"China will carry out the stable fiscal policy this year and cut down the fiscal deficit accordingly, plan to arrange a central fiscal deficit of RMB300 billion,which is RMB19.8 billion less than last year."

  13. Fiscal Deficit Will Be Cut Down RMB19.8 Billion This Year

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

      When delivering the government work report on March5, Premier Wen Jiabao said,"China will carry out the stable fiscal policy this year and cut down the fiscal deficit accordingly, plan to arrange a central fiscal deficit of RMB300 billion,which is RMB19.8 billion less than last year."……

  14. Application of radioisotopes Au -198 to radiometrical field investigation of spraying machine

    International Nuclear Information System (INIS)

    The poster shows application of radioisotope 198Au to radiometrical field testing of spraying machine. In the research was tested the Polish suspensioned tractor OZS400 type spraying machine. The machine worked in two different variants: without and with the beam stabilisation (oscillatory stabilisation)

  15. 14 CFR 198.13 - Premium insurance-payment of premiums.

    Science.gov (United States)

    2010-01-01

    ... (CONTINUED) WAR RISK INSURANCE AVIATION INSURANCE § 198.13 Premium insurance—payment of premiums. The insured must pay the premium for insurance issued under this part within the stated period after receipt of... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Premium insurance-payment of premiums....

  16. 14 CFR 198.1 - Eligibility of aircraft operation for insurance.

    Science.gov (United States)

    2010-01-01

    ... TRANSPORTATION (CONTINUED) WAR RISK INSURANCE AVIATION INSURANCE § 198.1 Eligibility of aircraft operation for... places all of which are outside the United States if insurance with premium is sought; or (2) In domestic... insurance without premium is sought; and (c) The Administrator finds that commercial insurance against...

  17. 14 CFR 198.15 - Non-premium insurance-payment of registration binders.

    Science.gov (United States)

    2010-01-01

    ... OF TRANSPORTATION (CONTINUED) WAR RISK INSURANCE AVIATION INSURANCE § 198.15 Non-premium insurance... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Non-premium insurance-payment of...-premium insurance must be accompanied by the proper binder, payable to the FAA. A binder is not...

  18. Production of 198Au and 192Ir sources for cancer therapy

    International Nuclear Information System (INIS)

    Radiation sources of 198Au and 192Ir in various types have been developed for cancer therapy, which are '198Au grains' and 'hairpin, single pin, thin wire, seed and seed assembly of 192Ir'. The products are being supplied to a number of cancer clinics in Japan. As target materials, gold metal and iridium/platinum alloy were used; iridium/platinum alloy gives flexibility to products and reduces pains in the patients. Grains and wires of the target materials were of platinum covered, and irradiated in the JRR-2 or JRR-4 reactor. The platinum cover absorbs the β rays of 198Au and 192Ir, which are not effective for cancer therapy. The neutron irradiation conditions were controlled to produce the following radioactivities: The 198Au grains are 185 MBq each at the time to be used in clinics, the 192Ir source radioactivities were, assayed at the time of shipment, 740 MBq each for the hairpin, 370 MBq for the single pin, 37 MBq for the seed, a radioactivity equivalent to 37 MBq multiplied by the number of seeds loaded for the seed assembly, and 148 MBq, 222 MBq or 370 MBq for the thin wire. There has been confirmed neither significant contamination of other radioactivities nor ununiformity of the radioactivity in the wire source. The radioactivities of products have been kept within ± 5% of an averaged value, except for the seed. For producing the seed assemblies, neutron irradiated seed and spacer teflon wires are loaded one by one into a teflon tube. This loading process and the measurement of radioactivities were automated to meet increased demands. In fiscal year 1989, the 198Au grains were produced in 48 batches and 2570 pieces were shipped and the 192Ir sources were produced in 39 batches and 4852 pieces were delivered, meeting all domestic demands. Being accompanied with the documents related to the production process, the present report is also usable as a production manual. (author)

  19. 15 CFR 19.8 - When will Commerce entities suspend or terminate debt collection on a Commerce debt?

    Science.gov (United States)

    2010-01-01

    ... CFR part 903 and the Commerce entity's policies and procedures. Legal counsel approval to suspend or... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false When will Commerce entities suspend or terminate debt collection on a Commerce debt? 19.8 Section 19.8 Commerce and Foreign Trade Office of...

  20. 19 CFR 19.8 - Examination of goods by importer; sampling; repacking; examination of merchandise by prospective...

    Science.gov (United States)

    2010-04-01

    ...; repacking; examination of merchandise by prospective purchasers. 19.8 Section 19.8 Customs Duties U.S... goods by importer; sampling; repacking; examination of merchandise by prospective purchasers. Importers... conduct of Customs business and no danger to the revenue prospective purchaser may be permitted to...

  1. ZNF198, a zinc finger protein rearranged in myeloproliferative disease, localizes to the PML nuclear bodies and interacts with SUMO-1 and PML

    International Nuclear Information System (INIS)

    The ZNF198/FGFR1 fusion gene in atypical myeloproliferative disease produces a constitutively active cytoplasmic tyrosine kinase, unlike ZNF198 which is normally a nuclear protein. We have now shown that the ZNF198/FGFR1 fusion kinase interacts with the endogenous ZNF198 protein suggesting that the function of ZNF198 may be compromised in cells expressing it. Little is currently known about the endogenous function of ZNF198 and to investigate this further we performed a yeast two-hybrid analysis and identified SUMO-1 as a binding partner of ZNF198. These observations were confirmed using co-immunoprecipitation which demonstrated that ZNF198 is covalently modified by SUMO-1. Since many of the SUMO-1-modified proteins are targeted to the PML nuclear bodies we used confocal microscopy to show that SUMO-1, PML and ZNF198 colocalize to punctate structures, shown by immunocytochemistry to be PML bodies. Using co-immunoprecipitation we now show that PML and sumoylated ZNF198 can be found in a protein complex in the cell. Mutation of the SUMO-1 binding site in wild-type ZNF198 resulted in loss of distinct PML bodies, reduced PML levels and a more dispersed nuclear localization of the PML protein. In cells expressing ZNF198/FGFR1, which also lack the SUMO-1 binding site, SUMO-1 is preferentially localized in the cytoplasm, which is associated with loss of distinct PML bodies. Recently, arsenic trioxide (ATO) was proposed as an alternative therapy for APL that was resistant to traditional therapy. Treatment of cells expressing ZNF198/FGFR1 with ATO demonstrated reduced autophosphorylation of the ZNF198/FGFR1 protein and induced apoptosis, which is not seen in cells expressing wild-type ZNF198. Overall our results suggest that the sumoylation of ZNF198 is important for PML body formation and that the abrogation of sumoylation of ZNF198 in ZNF198/FGFR1 expressing cells may be an important mechanism in cellular transformation

  2. Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter

    Energy Technology Data Exchange (ETDEWEB)

    Petrich, T.; Helmeke, H.-J.; Meyer, G.J.; Knapp, W.H.; Poetter, E. [Department of Nuclear Medicine, Medizinische Hochschule Hannover (Germany)

    2002-07-01

    The sodium/iodide symporter (NIS) has been recognized as an attractive target for radioiodine-mediated cancer gene therapy. In this study we investigated the role of human NIS for cellular uptake of the high LET {alpha}-emitter astatine-211 ({sup 211}At) in comparison with radioiodine as a potential radionuclide for future applications. A mammalian NIS expression vector was constructed and used to generate six stable NIS-expressing cancer cell lines (three derived from thyroid carcinoma, two from colon carcinoma, one from glioblastoma). Compared with the respective control cell lines, steady state radionuclide uptake of NIS-expressing cell lines increased up to 350-fold for iodine-123 ({sup 123}I), 340-fold for technetium-99m pertechnetate ({sup 99m}TcO{sub 4}{sup -}) and 60-fold for {sup 211}At. Cellular {sup 211}At accumulation was found to be dependent on extracellular Na{sup +} ions and displayed a similar sensitivity towards sodium perchlorate inhibition as radioiodide and {sup 99m}TcO{sub 4}{sup -} uptake. Heterologous competition with unlabelled NaI decreased NIS-mediated {sup 211}At uptake to levels of NIS-negative control cells. Following uptake both radioiodide and {sup 211}At were rapidly (apparent t{sub 1/2} 3-15 min) released by the cells as determined by wash-out experiments. Data of scintigraphic tumour imaging in a xenograft nude mice model of transplanted NIS-modified thyroid cells indicated that radionuclide uptake in NIS-expressing tumours was up to 70 times ({sup 123}I), 25 times ({sup 99m}TcO{sub 4}{sup -}) and 10 times ({sup 211}At) higher than in control tumours or normal tissues except stomach (3-5 times) and thyroid gland (5-10 times). Thirty-four percent and 14% of the administered activity of {sup 123}I and {sup 211}At, respectively, was found in NIS tumours by region of interest analysis (n=2). Compared with cell culture experiments, the effective half-life in vivo was greatly prolonged (6.5 h for {sup 123}I, 5.2 h for {sup 211}At) and

  3. Tritium stripping in a nitrogen glove box using palladium/zeolite and SAES St 198 trademark

    International Nuclear Information System (INIS)

    Glove box clean-up experiments were conducted in a nitrogen glove box using palladium deposited on zeolite (Pd/z) and a SAES St 198 trademark getter as tritium stripping materials. Protium/deuterium samples spiked with tritium were released into a 620 liter glove box to simulate tritium releases in a 10,500 liter glove box. The Pd/z and the SAES St 198 trademark stripper beds produced a reduction in tritium activity of approximately two to three orders of magnitude and glove box clean-up was limited by a persistent background tritium activity level. Attempts to significantly reduce the glove box activity to lower levels without purging were unsuccessful

  4. Synoviorthesis with 198Au colloid gold in haemophilia patients. A preliminary report

    International Nuclear Information System (INIS)

    In 1988-1989 fifteen patients with severe haemophilia A and recurrent bleedings into the knee joint, aged from 19 to 44 years were treated by an intraarticular injection of 198Au colloid gold. So far 10 of them were assessed after 6 months follow-up. In 6 cases cessation and in 2 cases reduction in number and volume of bleeding were observed. Only in 2 patients the frequency of haemarthroses remained unchanged. No significant difference in tracer uptake was observed between pretreatment 99mTc-pertrechnate gamma scans of the knee joints and controls completed 6 months after the radiogold injections. It is worthy to stress the lower costs of the 198Au synoviorthesis as compared with surgical synovectomy of the knee joint. The radioisotope method is also much less traumatic to the patient than the surgical one. (orig.)

  5. Influence of Corynebacterium parvum on the phagocytosis of 198Au colloids in rats

    International Nuclear Information System (INIS)

    The kinetics of the phagocytosis of gelatin-protected 198Au colloids in Wistar rats treated with Corynebacterium Parvum (CBP), was studied in order to explain its mechanism of immunomodulation. A previously developed extracorporeal blood circulation technique was used. The changes in the rate of phagocytosis, v, after the administration of CBP, for a dose of the 198Au colloid smaller or higher than the substratum constant, were studied. In the first case, no significant changes of v were observed; in the second case, significant increases of v were determined, which reached a maximum 6 days after the CBP administration. The kinetic analysis of the obtained data indicates that the action of CBP is exerted on the stage of the entrance of the colloidal particle into the reticuloendothelial cell. (author)

  6. Effect of acceleration of the decay rate of 198Au: a preliminary report

    International Nuclear Information System (INIS)

    Experimental evidence obtained at the Los Alamos National Laboratory during 1980 suggests that the decay rate of 198Au may be influenced to a measurable extent by acceleration of the bulk material. In the experiments, a sample of 198Au was subjected to a sustained acceleration of approximately 196,000 g's, and its decay rate was compared with that of a control sample that remained at rest. The decay probability of the accelerated sample was observed to exceed that of the control sample by 7.48 standard deviations. This was the maximum value resulting from comparison of the accelerated sample data and the control sample data. Although not conclusive, these preliminary data are certainly suggestive that a direct coupling may exist between gravitation (acceleration) and nuclear processes

  7. Magnetic rotations in 198Pb and 199Pb within covariant density functional theory

    OpenAIRE

    Yu, L. F.; Zhao, P. W.; Zhang, S.Q.; Ring, P.; Meng, J

    2011-01-01

    Well-known examples of shears bands in the nuclei 198Pb and 199Pb are investigated within tilted axis cranking relativistic mean-field theory. Energy spectra, the relation between spin and rotational frequency, deformation parameters and reduced $M1$ and $E2$ transition probabilities are calculated. The results are in good agreement with available data and with calculations based on the phenomenological pairing plus-quadrupole-quadrupole tilted-axis cranking model. It is shown that covariant ...

  8. Contact radiotherapy in rheumatoid lesion of the knee joints with the use of 198Au

    International Nuclear Information System (INIS)

    An instrumental-calculation method of assessment of an absorbed dose of radiation in the synovial tissue of the knee joint in radionuclide therapy with 198Au using directly measured topometric parameters was used for patients with rheumatoid arthritis. A group of 294 knee joint of 138 patients was considered by the way of a retrospective analysis. Dosimetric indices in all cases (except stage 4 arthritis) showed values which were not contrary to clinical assessment of the patients: status after therapy

  9. Screening and optimization of low-cost medium for Pseudomonas putida Rs-198 culture using RSM

    Directory of Open Access Journals (Sweden)

    Yanjie Peng

    2014-12-01

    Full Text Available The plant growth-promoting rhizobacterial strain Pseudomonas putida Rs-198 was isolated from salinized soils from Xinjiang Province. We optimized the composition of the low-cost medium of P. putida Rs-198 based on its bacterial concentration, as well as its phosphate-dissolving and indole acetic acid (IAA-producing capabilities using the response surface methodology (RSM, and a mathematical model was developed to show the effect of each medium component and its interactions on phosphate dissolution and IAA production. The model predicted a maximum phosphate concentration in medium containing 63.23 mg/L inorganic phosphate with 49.22 g/L corn flour, 14.63 g/L soybean meal, 2.03 g/L K2HPO4, 0.19 g/L MnSO4 and 5.00 g/L NaCl. The maximum IAA concentration (18.73 mg/L was predicted in medium containing 52.41 g/L corn flour, 15.82 g/L soybean meal, 2.40 g/L K2HPO4, 0.17 g/L MnSO4 and 5.00 g/L NaCl. These predicted values were also verified through experiments, with a cell density of 10(13 cfu/mL, phosphate dissolution of 64.33 mg/L, and IAA concentration of 18.08 mg/L. The excellent correlation between predicted and measured values of each model justifies the validity of both the response models. The study aims to provide a basis for industrialized fermentation using P. putida Rs-198.

  10. Comparison of Photolysis and Sonolysis Processes for Degradation of Reactive Red 198

    Directory of Open Access Journals (Sweden)

    A Maleki

    2010-07-01

    Full Text Available "n "n "nBackgrounds and Objectives: Carcinogenic and mutagenic potential of some azo dyes as a category of common dyes in different types of industries has been reported. The degradation of one commercially available dyestuff [C.I. Reactive Red 198 (RR 198] by means of ultraviolet radiation (UV, ultrasonic irradiation (US, UV/H2O2 and US/H2O2 processes was investigated."nMaterials and Methods: Photolysis process was accomplished in a laboratory-scale batch photoreactor equipped with an 55W immersed-type low-pressure mercury vapour lamp (UVC and sonication in a sonoreactor with low frequency (42 kHz plate type transducer at 170W of acoustic power with emphasis on the effect of various parameters on decolouration and degradation efficiency."nResults: Initial results showed that, color removal efficiencies by US and US/H2O2 processes were negligible. Almost complete disappearance of RR 198 (20 mg/L in UV/H2O2 process was possible to achieve after 10 min of irradiation. It is found that lower pH and lower concentration of dye favor the dye degradation. Hence any increase in initial dye concentration results in decreased decolouration rates. Also, the experimental results indicated that the kinetics of sono-oxidation and photo-oxidation processes fit well by pseudo-first order kinetics and first order reaction kinetics, respectively."nConclusion: It is concluded that UV/H2O2 reaction was more effective than other reactions in bleaching and the reaction rate was sensitive to the operational parameters and increased with increasing H2O2 concentration up to 15 mM.

  11. Inelastic proton scattering from 194,198Pt isotopes and the interacting boson model

    International Nuclear Information System (INIS)

    The purpose of this study was to obtain the direct excitation E4 matrix elements from the ground state to the first three 4+ states in 194,198Pt and analyze these results in the framework of the Interacting Boson Model (IBM). Specifically, the role played by g-bosons in the IBM has been investigated. Inelastic scattering using 135 MeV polarized protons was performed on 194,198Pt targets. Angular distributions of the cross section and analyzing power have been measured for the excitation of several low-lying levels: 01+, 21+, 22+, 31-, 41+, 42+, 43+, 51-, and 71- in both these isotopes. Coupled-channels analyses of the data revealed large negative hexadecapole moments for the first three 4+ states. The sign of only the 01+ → 41+ transition matrix element was unambiguously determined in these experiments. The first measurements of the magnitude of the matrix element for the transition, 01+ → 43+ are reported. The data for 198Pt has also provided a more accurate determination of the sign and magnitude of the matrix element for the transition, 01+ → 22+. These data were next analyzed using the IBM. Although the conventional form of the model, which includes only s- (L = 0) and d-(L = 2) bosons could describe the E2 properties adequately, this form failed badly in describing the observed E4 properties. However, when the model was extended to include a g- (L = 4) boson, both E2 and E4 properties of these nuclei were quite well reproduced. The parameters required for such calculations were reasonable in the context of this being an extension of the conventional IBM

  12. Deuterium absorption and material phase characteristics of SAES St 198 Zr-Fe Alloy

    International Nuclear Information System (INIS)

    This document reports deuterium absorption and material phase characteristics of SAES St 198 Zr-Fe Alloy (76.5% Zr). Scanning electron microscope images of polished surfaces, electron probe microanalysis, and x-ray powder diffractometry indicated the presence of a primary Zr2Fe phase with secondary phases of ZrFe2, Zr5FeSn, α-Zr, and Zr6Fe3O. A statistically designed experiment to determine the effects of temperature, time, and vacuum quality on activation of St 198 revealed that, when activated at low temperature (350C), deuterium absorption rate was slower when the vacuum quality was poor (2.5 Pa vs. 3 x 10-4 Pa). However, at higher activation temperature (500C), deuterium absorption rate was fast and was independent of vacuum quality. Deuterium pressure-composition-temperature (P-C-T) data are reported for St 198 in the temperature range 200 to 500C. The P-C-T data over the full range of deuterium loading and at temperatures of 350C and below is described an expression. At higher temperatures, one or more secondary reactions in the solid phase occur that slowly consume D2 from the gas phase. X-ray diffraction and other data suggest these reactions to be: 2 Zr2FeDx → xZrD2 + x/3 ZrFe2 + (2 - 2/3x) Zr2Fe and Zr2FeDx + (2 - 1/2x) D2 → 2 ZrD2 + Fe, where 0 2Fe formed in the first reaction accounts for the observed consumption of deuterium from the gas phase by this reaction

  13. 急性胰腺炎198例心电图结果分析%Acute Pancreatitis 198 Cases of Electrocardiogram Results Analysis

    Institute of Scientific and Technical Information of China (English)

    雷卫红

    2014-01-01

    目的:分析急性胰腺炎(AP)患者心电图(ECG)的改变及其临床意义。方法对198例AP患者的ECG检查结果进行分析。结果全组ECG异常改变者109例,异常率为55.1%,ECG正常者89例(44.9%);其中轻症急性胰腺炎(MAP)组ECG异常61例,重症急性胰腺炎(SAP)组48例,两组比较差异有高度显著性P<0.01(χ2=15.933);ECG异常主要表现为窦性心动过速、ST段降低和T波的改变等。结论 AP常伴有ECG的异常改变,故而采用ECG监测对判断AP的病情发展及转归具有较重要的临床价值。%ASBSTRACT:Objective Analysis of patients with acute pancreatitis (AP) of electrocardiogram (ECG) changes and its clinical signiifcance.Methods The ECG examination results of 198 patients with AP were analyzed.Results The group of 109 cases of abnormal changes of ECG, the abnormal rate was 55.1%, the ECG is normal, 89 cases (44.9%). Mild acute pancreatitis (MAP) group of ECG abnormalities in 61 cases, 48 cases of severe acute pancreatitis (SAP) group, two groups compare difference was highly signiifcant (P < 0.01 (χ2 = 15.933); ECG abnormalities mainly for sinus tachycardia, ST segment and T wave changes, etc.Conclusion AP often accompanied by changes of abnormal ECG, ECG monitoring on the judgement of the progression of AP and the outcome is of important clinical value.

  14. 女性肺癌198例临床分析%Clinical analysis of 198 eases of female lung cancer

    Institute of Scientific and Technical Information of China (English)

    杨福堂; 吕培瑾; 李燕

    2009-01-01

    Objective To Inquiry the causes of the lung cancer in female,sum up its clinical charac-teristics and misdiagnosis rate,to make a diagnosis and give treatment earlier. Methods Accept to 198 female lung cancers of complete case data in my hospital 10 years recently. Results The causes are closely related with outbreak from kitchen, air pollution and passive smoking etc. Currently, the trend turns to be young. Most sufferers take the symptom, such as cough, blood phlegm, chest pain, chest stuffy, as the first one. The gland cancer regards as principle pathologic type;The misdingnosis rate is the up to be 29%. Conclusion Doctors should pay more attention to the lung cancer in female. When suspected, the patients should be in time given the related medical examination including sputum, smear detection, CT, broncbescope ecc, to lower its misdiagnosis rate and improve its prognosiso%目的 探讨女性肺痛病因,了解其临床特点及漏误诊率,以极早诊治,改善预后.方法 对近10年本院收治的有完整病例资料的198例女性肺癌进行临床分析.结果 女性肺癌的发病与厨房油烟、大气污染及被动吸烟等密切相关,目前有年轻化趋势,多数患者以咳嗽、血痰、胸痛、胸闷为首发症状,病理类型以腺癌为主,其误漏诊率高达29%.结论 首诊医师应提高对女性肺癌的认识,对可疑患者及时行痰化验、CT、纤维支气管镜等检查,降低其误漏诊率,改善预后.

  15. Study of solid phase kinetics during cyanidation using the 198 Au radioactive tracer

    International Nuclear Information System (INIS)

    During cyanidation, the various gold bearing pyrite sorts exhibit different behaviour, that sometimes cause increased cyanidation times influencing the reagent and power consumption, in the same time generating fluctuations in the recovery efficiencies. The introduction of the 198 Au radioactive tracer into the cyanidation circuit enabled us to follow several parameters of the cyanidation kinetics: the average residence time of the gold bearing pyrite in the technological equipment, information about the homogenization process, dispersion of solids and gold dissolution efficiency on each technological stage. (author)

  16. Febrile Convulsion in Children: Clinical Analysis of 198 Cases%小儿高热惊厥198例临床分析

    Institute of Scientific and Technical Information of China (English)

    马赵峰

    2013-01-01

    目的 研究高热惊厥(FC)患儿的临床特征,寻找预防FC复发的措施.方法 分析198例FC患儿的临床资料,并于其出院后随访首次发病患儿138例,将复发FC患儿设为观察组,无复发FC患儿作为对照组;比较两组患儿年龄、性别、体温等方面的差异,并进行统计学分析.结果 小儿高热性惊厥多见于6个月~3岁,男多于女,有遗传相关性,病因以上呼吸道感染最常见;引起FC复发的相关因素有年龄、性别、体温、持续时间、惊厥类型、家族史.结论 多数FC患儿的预后良好,但复发率较高,对于有复发倾向患儿,实施及时有效的预防,可改善患儿的预后.

  17. A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro

    Directory of Open Access Journals (Sweden)

    Rathore K

    2015-09-01

    Full Text Available Kusum Rathore, Maria Cekanova Department of Small Animal Clinical Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN, USA Abstract: Doxorubicin (DOX is one of the most commonly used chemotherapeutic treatments for a wide range of cancers. N-benzyladriamycin-14-valerate (AD198 is a lipophilic anthracycline that has been shown to target conventional and novel isoforms of protein kinase C (PKC in cytoplasm of cells. Because of the adverse effects of DOX, including hair loss, nausea, vomiting, liver dysfunction, and cardiotoxicity, novel derivatives of DOX have been synthesized and validated. In this study, we evaluated the effects of DOX and its derivative, AD198, on cell viability of three canine transitional cell carcinoma (K9TCC (K9TCC#1-Lillie, K9TCC#2-Dakota, K9TCC#4-Molly and three canine osteosarcoma (K9OSA (K9OSA#1-Zoe, K9OSA#2-Nashville, K9OSA#3-JJ primary cancer cell lines. DOX and AD198 significantly inhibited cell proliferation in all tested K9TCC and K9OSA cell lines in a dose-dependent manner. AD198 inhibited cell viability of tested K9TCC and K9OSA cell lines more efficiently as compared to DOX at the same concentration using MTS (3-(4,5-dimethyl-2-yl-5-(3-carboxymethoxyphenyl-2-(4-sulfophenyl-2h-tetrazolium assay. AD198 had lower IC50 values as compared to DOX for all tested K9TCC and K9OSA cell lines. In addition, AD198 increased apoptosis in all tested K9TCC and K9OSA cell lines. AD198 increased the caspase activity in tested K9TCC and K9OSA cell lines, which was confirmed by caspase-3/7 assay, and cleavage of poly (ADP-ribose polymerase (PARP was confirmed by Western blotting analysis. In addition, AD198 cleaved PKC-δ, which subsequently activated the p38 signaling pathway, resulting in the apoptosis of tested K9TCC and K9OSA cell lines. Inhibition of the p38 signaling pathway by SB203580 rescued DOX- and AD198-induced apoptosis in tested K9TCC and K9OSA cell lines. Our in vitro results suggest

  18. Infrared studies of pre-main-sequence intermediate-mass stars - LkH-Alpha 198

    Science.gov (United States)

    Natta, Antonella; Palla, Francesco; Butner, Harold M.; Evans, Neal J., II; Harvey, Paul M.

    1992-01-01

    The paper presents FIR scans of LkH-Alpha 198 at 50 and 100 microns along several directions; the observations reveal an extended, roughly spherical source diameter of 33 arcsec, or 20,000 AU, at 100 microns and not more than 10 arcsec, or 15,000 AU, at 50 microns. A luminosity of 250 solar luminosities at a distance of 600 pc is estimated on the basis of a comparison of the observed properties at optical, IR, and millimeter wavelengths with the predictions of radiation transfer models. The optical depth at 100 microns is 0.004-0.006, implying a mass of about 2 solar masses with a radius of 10,000 AU. It is argued that the inner radius of the dusty envelope is rather small, less than about 300 AU (0.5 arcsec), and it may be as small as the dust destruction front: in LkH-Alpha 198 there is no evidence of a large region devoid of grains.

  19. Meningosis prophylaxis with intrathecal /sup 198/Au-colloid and methotrexate in childhood acute lymphocytic leukemia

    International Nuclear Information System (INIS)

    Since 1972, telecobalt irradiation plus intrathecal methotrexate (ITMTX) has been successfully replaced in Jena by intrathecal colloidal radioactive gold (/sup 198/Au) plus ITMTX for meningosis prophylaxis in leukemia. Seventy-three children with acute lymphocytic leukemia (ALL) were given 1.24-4.89 mCi (45.8-181 MBq) of colloidal 198Au IT after successful initiation of remission. During cytostatic therapy, the following relapses occurred: meningosis leucaemica, five patients (6.8%); bone-marrow relapse and the meningosis leucaemica, one patient; and bone-marrow relapse, 20 patients (27.4%). In 18 children, combination chemotherapy was terminated after two and a half or three years of treatment. After that time, one meningeal relapse and six bone-marrow relapses occurred. Within the first 24 hours after application of radioactive gold, headaches, vomiting, and fever occurred in less than 10% of the children. An apathy syndrome, leukecephalopathy, or severe infections, were not observed in a single case. Radioactive gold spreads in the subarachnoid space and is phagocytized by the arachnoidea. The tumoricide effect extends selectively over the space of distribution of the latent meningosis leucaemia. The cerebral parenchyma remains unaffected by radiation. Thus, radioactive gold may be preferable to telecobalt irradiation in preventing central nervous system leukemia

  20. Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Shukla, R.; Chanda, N.; Zambre, A.; Upendran, A.; Katti, K.; Kulkarni, R. R.; Nune, S. K.; Casteel, S. W.; Smith, C. J.; Vimal, J.; Boote, E.; Robertson, J. D.; Kan, P.; Engelbrecht, H.; Watkinson, L. D.; Carmack, T. L.; Lever, J. R.; Cutler, C. S.; Caldwell, C.; Kannan, R.; Katti, K. V.

    2012-07-16

    Systemic delivery of therapeutic agents to solid tumors is hindered by vascular and interstitial barriers. We hypothesized that prostate tumor specific epigallocatechingallate( EGCg) functionalized radioactive gold nanoparticles, when delivered intratumorally (IT), will circumvent transport barriers, resulting in targeted delivery of therapeutic payloads. The results described herein provide unequivocal validation of our hypothesis. We report the development of inherently therapeutic gold nanoparticles derived from Au-198 isotope; the range of 198Au β-particle ( ~ 11 mm in tissue or ~1100 cell diameters) is sufficiently long to provide cross-fire effects of radiation dose delivered to cells within the prostate gland and short enough to minimize radiation dose to critical tissues near the periphery of the capsule. The formulation of biocompatible 198AuNPs utilizes the redox chemistry of prostate tumor specific phytochemical EGCg as it converts gold salt into gold nanoparticles and also selectively binds with excellent affinity to Laminin67R receptors which are over expressed in prostate tumor cells. Pharmacokinetic studies in PC-3 xenograft SCID mice showed ~72% retention of 198AuNP-EGCg in tumors 24 h after intratumoral administration. Therapeutic studies showed 80% reduction of tumor volumes after 28 days demonstrating significant inhibition of tumor growth compared to controls. This innovative “green nanotechnological“approach serves as a basis for designing target specific antineoplastic agents. This novel intratumorally injectable 198AuNP-EGCg nanotherapeutic agent may provide significant advances in oncology for use as an effective treatment for prostate and other solid tumors.

  1. Magnetic rotations in 198Pb and 199Pb within covariant density functional theory

    CERN Document Server

    Yu, L F; Zhang, S Q; Ring, P; Meng, J

    2011-01-01

    Well-known examples of shears bands in the nuclei 198Pb and 199Pb are investigated within tilted axis cranking relativistic mean-field theory. Energy spectra, the relation between spin and rotational frequency, deformation parameters, and reduced M1 and E2 transition probabilities are calculated. The results are in good agreement with available data and with calculations based on the phenomenological pairing plus-quadrupole-quadrupole tilted axis cranking model. It is shown that covariant density functional theory provides a successful microscopic and fully self-consistent description of magnetic rotation in the Pb region showing the characteristic properties as the shears mechanism and relatively large B(M1) transitions decreasing with increasing spin.

  2. The efficacy of gold-198 grain mold therapy for mucosal carcinomas of the oral cavity

    International Nuclear Information System (INIS)

    Gold-198 grain mold therapy was given to 27 patients with 29 oral cancers and the results were analysed. Single plane mold alone was chosen for treatment when the maximum thickness of the tumor was below 2 mm. For thicker tumors, external irradiation prior to mold therapy was added. The 5-year survival following these principles was 82%. Initial tumor control was obtained in all 27 lesions followed for more than 2 years but recurrence took place in 7 (26%). Of 20 patients whose primary lesion did not recur within 2 years, 6 subsequently required surgery (2 cases) or non-surgical treatment (4 cases) for bone complications. The results obtained by single plane mold therapy are encouraging, particularly with regard to gum cancers showing a minimum bone invasion, and should therefore be advocated for selected patients with oral carcinoma. (orig.)

  3. Possible chirality in the doubly-odd 198Tl nucleus: Residual interaction at play

    International Nuclear Information System (INIS)

    A candidate for chiral bands was found in 198Tl for the first time in a mass region of oblate (or nonaxial with γ≥30 deg.) deformed nuclei. Two bands show very similar quasiparticle alignments, moments of inertia, and B(M1)/B(E2) ratios. They have a relative excitation energy of about 500 keV and different patterns of energy staggering. Calculations using the two-quasiparticle-plus-triaxial-rotor model with residual proton-neutron interaction included show that a triaxial deformation with γ∼44 deg. agrees very well with all the experimental observations. Furthermore, considerable energy staggering for both partner bands was calculated for this πh9/2 x νi13/2-1 configuration at γ∼30 deg., suggesting that chiral bands may have substantial energy staggering

  4. 194,198Pt(p vector,p') reaction and the interacting boson model

    International Nuclear Information System (INIS)

    Angular distributions of dσ/dΩ and Ay were measured for low-lying collective states, Jπ=01+, 21+, 22+, 41+, 42+, 43+ in 194,198Pt using 135 MeV polarized protons. Coupled-channels analysis of the data indicates large E4 moments for the 4i (i=1, 2, 3) states in both the isotopes. These data have been analyzed in the framework of the interacting boson model (IBM). Although the standard IBM-1 scheme with only s- and d-bosons can describe the E2 properties of both isotopes quite well, a more generalized version which also includes a g-boson is needed to correctly reproduce simultaneously both the E2 and E4 data. Another model using the 'projected IBM-2' parameters gives similar results. (orig.)

  5. Study of collisions of 136Xe + 198Pt for the KEK isotope separator

    Science.gov (United States)

    Watanabe, Y. X.; Hirayama, Y.; Imai, N.; Ishiyama, H.; Jeong, S. C.; Miyatake, H.; Clement, E.; de France, G.; Navin, A.; Rejmund, M.; Schmitt, C.; Pollarolo, G.; Corradi, L.; Fioretto, E.; Montanari, D.; Choi, S. H.; Kim, Y. H.; Song, J. S.; Niikura, M.; Suzuki, D.; Nishibata, H.; Takatsu, J.

    2013-12-01

    Multinucleon transfer reactions between two heavy ions are an important tool for production and investigation of exotic neutron-rich nuclei, which are difficult to access by other methods. The 136Xe + 198Pt system is a candidate to efficiently produce neutron-rich nuclei around the neutron magic number N=126 for the KEK isotope separation project. In order to confirm this, measurements of the production cross sections with the large acceptance magnetic spectrometer VAMOS++ and de-excitation gamma rays from target-like fragments using the high efficiency germanium array EXOGAM at GANIL are reported. The measured isotopic distributions of the projectile-like fragments are compared with GRAZING calculations. The proton stripping channels show rough agreements between measurements and calculations. For the proton pick-up channels, the measured distributions are shifted toward the heavier masses and show enhanced cross sections in transfers of two or more protons.

  6. Hepatosplenic scanning with 198Au colloidal gold in chronic myelogenous leukemia

    International Nuclear Information System (INIS)

    From January 1975 to March 1978, 18 cases of chronic myelogenous leukemia diagnosed at Kyungpook National University Hospital were tested by hepatosplenic scanning with 198Au colloidal gold. The photo scanning findings in relation to clinical and laboratory findings are following. Male to female ratio was 2:1 and 2nd and 3rd decades were predominant. No focal space-occupying lesion was noticed both in the liver and spleen. 4 cases revealed well visualization of spleen, 7 cases poor visualization, and 7 cases nonvisualization. No significant difference between well visualization group and poor visualization group was noted in clinical findings, liver function test and hematologic findings. Cases with nonvisualization of the spleen tended to be associated with thrombocytopenia, decreased megakaryocytes in the marrow and longer duration of the illness. (author)

  7. Hepatosplenic Scanning with 198Au Colloidal Gold in Chronic Myelogenous Leukemia

    International Nuclear Information System (INIS)

    From January 1975 to March 1978, 18 cases of chronic myelogenous leukemia diagnosed at Kyungpook National University Hospital were tested by hepatosplenic scanning with 198Au Colloidal gold. The photo scanning findings in relation to clinical and laboratory findings are following. 1) Male to female ratio was 2:1 and 2nd and 3rd decades were predominant. 2) No focal space-occupying lesion was noticed both in the liver and spleen. 3) 4 Cases revealed well visualization of spleen, 7 cases poor visualization, and 7 cases nonvisualization. 4) No significant difference between well visualization group and poor visualization group was noted in clinical findings, liver function test and hematologic findings. 5) Cases with nonvisualization of the spleen tended to be associated with thrombocytopenia, decreased megakaryocytes in the marrow and longer duration of the illness.

  8. Gold-198 and rose bengal marked with iodine-131 in the diagnostic of hepatic vesicular affections

    International Nuclear Information System (INIS)

    Colloidal gold-198 makes it possible to obtain clear images of hepatic parenchyma; the examination can be repeated from different angles thus demonstrating the presence of pathologically inert regions, whether they be hydatic cysts, abscesses or neoplasia. The study of the disappearance curve for the colloid, together with a measurement of the blood volume, makes it possible also to calculate the hepatic flow. Using Rose Bengal marked with iodine-131, it is possible to obtain images of the liver and of the bile ducts, and to follow the elimination of the dye in the intestines. The simultaneous recording of the disappearance curves for the blood and of the appearance of the dye in the intestines constitutes an useful working test which is particularly sensible for evaluating the permeability of the bile ducts and, to a certain degree, the site of an obstruction. (author)

  9. Durable donor engraftment after radioimmunotherapy using α-emitter astatine-211-labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation.

    Science.gov (United States)

    Chen, Yun; Kornblit, Brian; Hamlin, Donald K; Sale, George E; Santos, Erlinda B; Wilbur, D Scott; Storer, Barry E; Storb, Rainer; Sandmaier, Brenda M

    2012-02-01

    To reduce toxicity associated with external γ-beam radiation, we investigated radioimmunotherapy with an anti-CD45 mAb labeled with the α-emitter, astatine-211 ((211)At), as a conditioning regimen in dog leukocyte antigen-identical hematopoietic cell transplantation (HCT). Dose-finding studies in 6 dogs treated with 100 to 618 μCi/kg (211)At-labeled anti-CD45 mAb (0.5 mg/kg) without HCT rescue demonstrated dose-dependent myelosuppression with subsequent autologous recovery, and transient liver toxicity in dogs treated with (211)At doses less than or equal to 405 μCi/kg. Higher doses of (211)At induced clinical liver failure. Subsequently, 8 dogs were conditioned with 155 to 625 μCi/kg (211)At-labeled anti-CD45 mAb (0.5 mg/kg) before HCT with dog leukocyte antigen-identical bone marrow followed by a short course of cyclosporine and mycophenolate mofetil immunosuppression. Neutropenia (1-146 cells/μL), lymphopenia (0-270 cells/μL), and thrombocytopenia (1500-6560 platelets/μL) with prompt recovery was observed. Seven dogs had long-term donor mononuclear cell chimerism (19%-58%), whereas 1 dog treated with the lowest (211)At dose (155 μCi/kg) had low donor mononuclear cell chimerism (5%). At the end of follow-up (18-53 weeks), only transient liver toxicity and no renal toxicity had been observed. In conclusion, conditioning with (211)At-labeled anti-CD45 mAb is safe and efficacious and provides a platform for future clinical trials of nonmyeloablative transplantation with radioimmunotherapy-based conditioning. PMID:22134165

  10. Molecular risk assessment of BIG 1-98 participants by expression profiling using RNA from archival tissue

    OpenAIRE

    Giobbie-Hurder Anita; Thürlimann Beat; Oberli Andrea; Baltzer Anna; Wirapati Pratyaksha; Delorenzi Mauro; Popovici Vlad; Antonov Janine; Viale Giuseppe; Altermatt Hans; Aebi Stefan; Jaggi Rolf

    2010-01-01

    Abstract Background The purpose of the work reported here is to test reliable molecular profiles using routinely processed formalin-fixed paraffin-embedded (FFPE) tissues from participants of the clinical trial BIG 1-98 with a median follow-up of 60 months. Methods RNA from fresh frozen (FF) and FFPE tumor samples of 82 patients were used for quality control, and independent FFPE tissues of 342 postmenopausal participants of BIG 1-98 with ER-positive cancer were analyzed by measuring prospect...

  11. ramR Mutations Affecting Fluoroquinolone Susceptibility in Epidemic Multidrug-Resistant Salmonella enterica Serovar Kentucky ST198

    Directory of Open Access Journals (Sweden)

    AxelCloeckaert

    2013-07-01

    Full Text Available A screening for non-target mutations affecting fluoroquinolone susceptibility was conducted in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198. Among a panel of representative isolates (n=30, covering the epidemic, only three showed distinct mutations in ramR resulting in enhanced expression of genes encoding the AcrAB-TolC efflux system and low increase in ciprofloxacin MIC. No mutations were detected in other regulatory regions of this efflux system. Ciprofloxacin resistance in serovar Kentucky ST198 is thus currently mainly due to multiple target gene mutations.

  12. Intrathecal application of 198Au colloid in acute leukemia and non-Hodgkin's lymphoma in chilhood. 2

    International Nuclear Information System (INIS)

    7 children suffering from acute lymphatic leukemia (ALL) and non-Hodgkin's lymphoma, resp., were injected intrathecally with 198Au colloid for metaphylaxis. The children had been cured of 8 relapses of miningosis and received irregularly intrathecal injections of methotrexate for cerebral maintenance therapy. The median cerebral period of remission was 52 weeks. 1 child suffering from ALL had been free from meningosis relapses for 128 weeks. Continuous cytostatic therapy is necessary for methaphylaxis. However, despite of the good results presented, 198Au colloid can not be recommended for long-term therapy because radiation injuries are to be expected. (author)

  13. Lower expressed miR-198 and its potential targets in hepatocellular carcinoma: a clinicopathological and in silico study

    Directory of Open Access Journals (Sweden)

    Huang WT

    2016-08-01

    Full Text Available Wen-Ting Huang,1,* Han-Lin Wang,1,* Hong Yang,2 Fang-Hui Ren,1 Yi-Huan Luo,1 Chun-Qin Huang,1 Yue-Ya Liang,1 Hai-Wei Liang,1 Gang Chen,1 Yi-Wu Dang1 1Department of Pathology, 2Department of Ultrasonography, First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China *These authors contributed equally to this work Purpose: To investigate the clinicopathological value and potential roles of microRNA-198 (miR-198 in hepatocellular carcinoma (HCC.Methods: Ninety-five formalin-fixed paraffin-embedded HCC and the para-cancerous liver tissues were gathered. Real-time reverse transcription quantitative polymerase chain reaction was applied to determine the miR-198 expression. The association between the miR-198 expression and clinicopathological features was examined. Meanwhile, potential target messenger RNAs of miR-198 in HCC were obtained from 14 miRNA prediction databases and natural language processing method, in which we pooled the genes related to the tumorigenesis and progression of HCC and classified them by their frequency. The selected target genes were finally analyzed in the Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway.Results: miR-198 expression was significantly lower in HCC than that in adjacent noncancerous liver tissues (1.30±0.72 vs 2.01±0.58, P<0.001. Low miR-198 expression was also correlated to hepatitis C virus infection (r=-0.48, P<0.001, tumor capsular infiltration (r=-0.43, P<0.001, metastasis (r=-0.26, P<0.010, number of tumor nodes (r=-0.25, P=0.013, vaso-invasion (r=-0.24, P=0.017, and clinical tumor node metastasis stage (r=-0.23, P=0.024. Altogether, 1,048 genes were achieved by the concurrent prediction from at least four databases and natural language processing indicated 1,800 genes for HCC. Further, 127 overlapping targets were further proceeded with for pathway analysis. The most enriched Gene Ontology terms in the potential target messenger RNAs of mi

  14. 198Au grain implantation for early tongue cancer in patients of advanced age or poor performance status

    International Nuclear Information System (INIS)

    Brachytherapy using 198Au grains is minimally invasive and the only curative treatment for early tongue cancer in patients of advanced age or poor performance status available in our institution. From March 1993 to February 2008, 198Au grains were used to treat a group of 96 Stage I–II tongue cancer patients who could not undergo surgery or brachytherapy using 192Ir pins because of an advanced age (≥75 years) or poor performance status (≥2). The patients were followed for 3.9 ± 3.3 years, and the cause-specific survival and local control rates were determined. Survival analyses were performed using the Kaplan-Meier method, and univariate and multivariate analyses were performed using the Cox proportional hazard model. The results were compared with those for a group of 193 early tongue-cancer patients who underwent treatment using iridium pins. The 5-year cause-specific survival and local control rates of the 198Au grains group were 71% and 68%, respectively, both of which were 16% lower than the corresponding rates for the 192Ir pins group. Our study demonstrated that as the last curative treatment available, 198Au grain implantation could be used to achieve moderate treatment results for early tongue cancer in patients of advanced age or poor performance status

  15. Use of 198 Au, with surface labelling, in the study of solid transport by bed load in large natural channels

    International Nuclear Information System (INIS)

    The present study aims to present a method of measuring the bed load transport using a radioisotope technique in large natural channels. This study describes the basic principles of radioisotope application in this field, emphasizing the use of 198 Au for surface labelling of a natural sediment. Moreover, it presents the theoretical aspects, critical analysis, recommendations and comments on the methodology proposed. (author)

  16. Bone-Marrow Scanning after Intravenous Injection of Colloidal Gold-198

    International Nuclear Information System (INIS)

    Colloidal Au198 is, after intravenous injection, rapidly removed from the blood by reticulo-endothelial activity. Most of the injected colloid is taken up by liver, but a small part is taken up by spleen and bone marrow. Bone-marrow uptake was studied in a large number of patients by means of total body scintigrams and total body profile counting. Three main patterns of distribution could be distinguished. (1) Normal pattern: In patients without bone-marrow disease, uptake of Au198 was limited to the central parts of bone system (thorax, spine, pelvis, skull and proximal epiphyses of femur and humerus), i.e. normal sites for active red bone marrow. With the exception of the proximal epiphyses of femur and humerus no, or only a very slight, uptake was found in the bones of arms and legs. (2) Hyperplastic pattern: This type of distribution was found in polycythaemia vera and haemolytic conditions. Bone-marrow uptake was increased and, besides the central parts of bone system, considerable uptake was often demonstrated in the long bones of arms and legs. (3) Destructive pattern: This pattern was regularly found in myelofibrosis and very often in leukaemia, bone-marrow carcinomatosis and malignant lymphoma with bone-marrow involvement. It was characterized by general reduction of bone-marrow uptake in central parts of the body, combined with increased uptake in the long bones of legs and arms due to compensatory peripheral haematopoiesis. All degrees of bone-marrow destruction and compensatory peripheral hyperplasia could in this way be visualized. By means of total body profile counting it was possible to obtain a more quantitative and reproducible expression for bone-marrow uptake. Repeated examinations were performed in cases of polycythaemia vera; in some cases it was possible to follow the changes in bone-marrow uptake which occurred when polycythaemia vera developed into a stage of myelofibrosis. In detailed scintigrams of the pelvis, it was also possible to

  17. 麻疹198例流行病学和临床分析

    Institute of Scientific and Technical Information of China (English)

    支雅庆

    2012-01-01

    目的探讨麻疹流行病学和临床分析,以期更好地预防和控制麻疹.方法对住院的麻疹患者198例的临床资料进行回顾性分析.结果从1周岁的小儿至60岁成人均有发病,以≥18岁的成人发病率最高(28.8%),且有增加趋势,农村及城郊人群比例较高(65.7%),有明确麻疹疫苗接种史者占23.2%,有明确麻疹接触史占9.1%,临床症状典型,腹泻者多见,易损害肝脏,并发症不多,早期容易误诊.结论对麻疹患者早诊断、早隔离、早治疗,对易感者加强麻疹疫苗接种是预防和控制麻疹的关键.%Objective To investigate the epidemiological and clinical analysis of measles, in order to better prevention and control of measles. Methods: in198 cases of measles in patients clinicaldata were retrospectively analyzed. Results: from 1 years to 60 years into the childrenhave per capita incidence, with>18years of adult incidence washighest (28.8%), andhad the tendency of increasing, rural and suburban population proportion ishigher (65.7%), there is a clearhistory of measles vaccination of measles was 23.2%, with clear contact Shi Zhan 9.1%, typical clinical symptoms,diarrhea in common, easy todamage the liver, complications are not common, early misdiagnosis. Conclusion: earlydiagnosis of measles patients, early isolation and early treatment, for susceptible to strengthen measles vaccination as the prevention and control of measles in the key.

  18. Evaporation residue excitation function measurement for 19F + 194,198Pt reactions

    International Nuclear Information System (INIS)

    Nuclear dissipation is one of the active fields in the present day nuclear physics research. Experimental signatures for dissipation are observed through large excess in pre-fission neutrons, γ-ray multiplicities from the compound nucleus, giant dipole resonance (GDR) γ-rays, light charged particles and evaporation residues in comparison to standard statistical model, for the heavy-ion induced fusion-fission or fusion-evaporation reactions (ERs). From the analysis of a large set of experimental data, it is well established that there exists a large dissipation at nuclear temperature above 1 MeV. But most of these probes are not sensitive to the dissipation within saddle. The ER cross-section is a probe which is sensitive to dissipation within the saddle point. Hence, the study of ER cross-section can be helpful in estimating the dissipation effects inside the saddle point. Also the other motivation for these measurements is to see the effect of shell closure on dissipation. With this motivation the evaporation cross-sections for 19F + 194,198Pt are measured at beam energy of 101 to 137.3 MeV. Of the above systems 19F + 194Pt populates 213Fr (N = 126) shell closed compound nucleus (CN) whereas, other system populate 217Fr (N = 130) non-shell closed CN

  19. Results of infusion of pleural and peritoneal calcinoses with colloidal radiogold Au-198

    International Nuclear Information System (INIS)

    This study begins with a general part, containing a description of the usual techniques, a summary of the side effects and complications and also a survey over the indications and contra-indications. This chapter is followed by the evaluation of the histologies taken of 572 patients with 744 applications. These patients received infusions of Au-198 intrapleurally and/or intraperitoneally between Januray 1st, 1960 and December 31st, 1970, in the Rudolf-Virchow Hospital, Berlin. The consideration of the overall patient population is followed by a classification of the individual primary tumours according to various aspects. In order to judge about the effectiveness of the applied radiogold therapy, we calculated the average survival times of the individual patient groups and additionally we assessed the influence due to effusion. For the 155 patients who received radiogold intrapleurally once, a rate of success of 56.1% resulted; this rate was 58.8% for the 58 patients suffering from carcinoma of the breast, and for the 59 patients with bronchial carcinoma this rate was 56.1%. Correspondingly we calculated a rate of success of 40.4% for 94 patients with intraperitoneal radiogold infusion and ascites. In the 57 patients suffering from ovarian tumours and ascites, we found a rate of success of 57.9%. Ten patients, who received radiogold not only intrapleurally, but also intraperitoneally, showed a mean survival rate of 16 months. (orig./MG)

  20. Treatment of periocular tumours of horses using radioactive gold198 grains

    International Nuclear Information System (INIS)

    The literature is briefly reviewed concerning the clinical features of equine cutaneous tumours. The data from 19 horses with periocular skin tumours are reported together with the results of their treatment by implantation with radioactive gold198. The principles governing the implantation of radioactive sources are explained and a method for computing the initial activity of the sources is outlined. Five histologically different tumours were treated in this series of 19 horses, 2 horses were bilaterally affected. The techniques of implantation using a simple needle/stilette combination and a purpose built gold grain implantation gun are described and the post-operative course of the animals is traced. The treatment was successful in ablating the tumour mass and preventing regrowth in 19 of 21 periocular tumour groups. The cosmetic effects of the treatment were found to be satisfactory. Emphasis is laid on the care needed in handling the radioactive material and on the need for a thorough understanding of the principles involved in radiotherapy. Doses received by the operator during an implantation procedure are quoted which show that the technique is safe as well as being effective. (author)

  1. Study of application and testing of the experimental fuel assembly with 36 %, 19.8% enrichment

    International Nuclear Information System (INIS)

    Study of application and testing of the experimental fuel assembly with 36% enrichment in U-235, the fuel developed by Russian Federation at the WWR-SM research reactor of INP - Institute of Nuclear Physics (the Republic of Uzbekistan). The WWR-SM reactor of INP currently uses FA of the IRT-3M type containing uranium with an enrichment of 36% in U-235. The density of uranium in the fuel meat is 2.5 g/cm3. The reactor has a high operating efficiency (6400 hours per year) at a maximum power of 10 MW. For research reactors in countries of the Former Soviet Union (FSU), nuclear fuel assemblies (FA) containing low-enriched uranium (LEU), which meet the international requirements, have not yet been developed. Scientists at Institute 'Kurchatov' together with scientists at the INP are currently developing the fuel elements with an enrichment of 36%, (19.8% IRT-4M type) in U-235 that meets the requirements of IAEA. (author)

  2. Treatment of Sulfonated Azo Dye Reactive Red 198 by UV/H2O2

    Directory of Open Access Journals (Sweden)

    Jefferson P. Ribeiro

    2014-01-01

    Full Text Available UV/H2O2 system was tested on the color removal of sulfonated azo dye Reactive Red 198 (RR, which is widely used in textile process. The effects of hydrogen peroxide concentration, temperature, pH, and the in-line addition of hydrogen peroxide on high color and chemical oxygen demand (COD removals were investigated. The kinetic of dye decolorization was also determined. The results showed that 2% H2O2 decreased the process efficiency, while 1% H2O2 solution led to a better performance of the system. Despite the fact that the pH increase had small effect on color removal, it affects positively COD removals. The same behavior was found for temperature increase. A high temperature resulted in a slight decrease in color removal and a sharp decrease for COD removal. In addition the H2O2 in-line provided a small improvement in both color and COD removals. UV/1% H2O2 treatment was the most efficient, the good performance was linked to higher amount of hydroxyl radicals formed.

  3. Crossing of large multiquasiparticle magnetic-rotation bands in 198Bi

    Science.gov (United States)

    Pai, H.; Mukherjee, G.; Bhattacharyya, S.; Bhattacharya, C.; Bhattacharya, S.; Bhattacharjee, T.; Basu, S. K.; Kundu, S.; Ghosh, T. K.; Banerjee, K.; Rana, T. K.; Meena, J. K.; Bhowmik, R. K.; Singh, R. P.; Muralithar, S.; Chanda, S.; Garg, R.; Maheshwari, B.; Choudhury, D.; Jain, A. K.

    2014-12-01

    High-spin states in the doubly-odd 198Bi nucleus have been studied by using the Re,187185 (16O ,x n ) reactions at a beam energy of 112.5 MeV. γ -γ coincidences, directional correlation ratio, and integrated polarization asymmetry ratio were measured by using the INGA array with 15 Compton-suppressed clover high-purity germanium (HPGe) detectors. Definite spins and parities were assigned to the observed levels. The high-spin structure is grouped into three bands (B1, B2, and B3), of which two (B1 and B2) exhibit the properties of magnetic rotation (MR). Tilted axis cranking calculations were carried out to explain the MR bands having large multiquasiparticle (qp) configurations. The calculated results explain the bands B1 and B2 very nicely, confirming the shears mechanism and suggest a crossing of two MR bands in both the cases. The crossing is from 6-qp to 8-qp in band B1 and from 4-qp to 6-qp in band B2, a very rare finding. A semiclassical model has also been used to obtain the particle-hole interaction strengths below the band crossing for the bands B1 and B2.

  4. Crossing of large multi-quasiparticle magnetic rotation bands in $^{198}$Bi

    CERN Document Server

    Pai, H; Bhattacharya, S; Bhattacharya, C; Bhattacharyya, S; Bhattacharjee, T; Basu, S K; Kundu, S; Ghosh, T K; Banerjee, K; Rana, T K; Meena, J K; Bhowmik, R K; Singh, R P; Muralithar, S; Chanda, S; Garg, R; Maheshwari, B; Jain, A K

    2014-01-01

    High-spin states in the doubly-odd $^{198}$Bi nucleus have been studied by using the $^{185,187}$Re($^{16}$O, xn) reactions at the beam energy of 112.5 MeV. $\\gamma-\\gamma$ coincidence were measured by using the INGA array with 15 Compton suppressed clover HPGe detectors. The observed levels have been assigned definite spin-parity. The high spin structure is grouped into three bands (B1, B2 and B3), of which two (B1 and B2) exhibit the properties of magnetic rotation (MR). Tilted axis cranking calculations were carried out to explain the MR bands having large multi-quasiparticle configurations. The calculated results explain the bands B1 and B2 very nicely, confirming the shears mechanism and suggest a crossing of two MR bands in both the cases. The crossing is from 6-qp to 8-qp in band B1 and from 4-qp to 6-qp in band B2, a very rare finding. A semiclassical model has also been used to obtain the particle-hole interaction strengths for the bands B1 and B2, below the band crossing.

  5. t198gb.m77t and t198gb.h77t: MGD77T data and header files for single-beam bathymetry data for field activity T-1-98-GB in Glacier Bay, Alaska from 08/21/1998 to 09/01/1998

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise T-1-98-GB. The cruise was conducted in...

  6. ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers.

    Directory of Open Access Journals (Sweden)

    Christian B Gocke

    Full Text Available Histone modifications in chromatin regulate gene expression. A transcriptional co-repressor complex containing LSD1-CoREST-HDAC1 (termed LCH hereafter for simplicity represses transcription by coordinately removing histone modifications associated with transcriptional activation. RE1-silencing transcription factor (REST recruits LCH to the promoters of neuron-specific genes, thereby silencing their transcription in non-neuronal tissues. ZNF198 is a member of a family of MYM-type zinc finger proteins that associate with LCH. Here, we show that ZNF198-like proteins are required for the repression of E-cadherin (a gene known to be repressed by LSD1, but not REST-responsive genes. ZNF198 binds preferentially to the intact LCH ternary complex, but not its individual subunits. ZNF198- and REST-binding to the LCH complex are mutually exclusive. ZNF198 associates with chromatin independently of LCH. Furthermore, modification of HDAC1 by small ubiquitin-like modifier (SUMO in vitro weakens its interaction with CoREST whereas sumoylation of HDAC1 stimulates its binding to ZNF198. Finally, we mapped the LCH- and HDAC1-SUMO-binding domains of ZNF198 to tandem repeats of MYM-type zinc fingers. Therefore, our results suggest that ZNF198, through its multiple protein-protein interaction interfaces, helps to maintain the intact LCH complex on specific, non-REST-responsive promoters and may also prevent SUMO-dependent dissociation of HDAC1.

  7. Application of {sup 198}Au grains for carcinoma of oral cavity

    Energy Technology Data Exchange (ETDEWEB)

    Shimizutani, K. [Dept. of Oral Radiology, Osaka Dental University, Osaka (Japan); Koseki, Y. [Dept. of Oral Radiology, Osaka Dental University, Osaka (Japan); Inoue, To. [Dept. of Radiation Oncology, Biomedical Research Center, Osaka University Medical School, Osaka (Japan); Teshima, T. [Dept. of Radiology, Osaka University Medical School, Osaka (Japan); Furukawa, S. [Dept. of Oral and Maxillofacial Radiology, Osaka University, Faculty of Dentistry, Osaka (Japan); Kubo, K. [Dept. of Oral and Maxillofacial Radiology, Osaka University, Faculty of Dentistry, Osaka (Japan); Fachihata, H. [Dept. of Oral and Maxillofacial Radiology, Osaka University, Faculty of Dentistry, Osaka (Japan); Masaki, N. [Dept. of Therapeutic Radiology, Center for Adult Diseases, Osaka (Japan); Ikeda, H. [Dept. of Radiation Oncology, National Cancer Center Hospital, Tokyo (Japan); Tanaka, Y. [Dept. of Dentistry, Kobe Municipal Chuo Hospital, Kobe (Japan)

    1995-01-01

    The purpose of this study is to analyze the results of the treatment using gold grain implants over the past 9 years and to evaluate the usefulness of this treatment method. From January 1985 through April 1993, a total of 45 patients with squamous cell carcinomas of the oral cavity and the oropharynx were treated with {sup 198}Au grain (gold grain) at the Department of Radiology, Osaka University Medical School. The initial activity of the grains supplied weekly by the Japan Radioisotope Association was usually 5 mCi (185 MBq), and single implants were usual. In case of combined external irradiation, telecobalt {gamma}-rays or 4 MV X-rays were used for treatment before implant. The local control rate for patients with T1 stages was 80% (20/25) and with T2 stages, 59% (10/17). The local control rate was 71% (10/14) for gold grain alone and 72% (13/18) for external irradiation combined with gold grain implants (combined therapy). In combined therapy, the median of the interval between external irradiation and gold grain implants was 21 days. The treatment interval or patients with recurrent diseases was 22 days, 22, 27, 39 and 46, respectively. The progression rate showed a tendency to increase in the patients with longer interval (more than 21 days), and with partial regression after external irradiation and gold grain implantation is an important factor in combined therapy. Therefore, we emphasize that the time interval should be shorter than 3 weeks. (orig.) [Deutsch] Ziel dieser Untersuchung sind die Analyse der Behandlungsergebnisse der letzten neun Jahre bei Verwendung von Gold-Seed-Implantaten und die Bestimmung der Wertigkeit dieser Methode. Von Januar 1985 bis April 1993 wurden insgesamt 45 Patienten mit Plattenepithelkarzinomen der Mundhoehle und des Oropharynx mit {sup 198}Au-Seeds im Department of Radiology der Osaka University medical School behandelt. Die Ausgangsaktivitaet der Seeds war ueblicherweise 5 mCi (185 MBq), sie wurden woechentlich von der

  8. Treatment of Synthetic Wastewater Containing Reactive Red 198 by Electrocoagulation Process

    Directory of Open Access Journals (Sweden)

    N.M Mahmoodi

    2011-04-01

    Full Text Available "nBackground and Objectives: Discharge of textile colored wastewater industries without providing enough treatment in water bodies, is harmful for human and aquatic organisms and poses serious damages to the environment. Most of conventional wastewater treatment methods don't have enough efficiency to remove textile dyes from colored wastewater; thus in this research the efficiency of electrocoagulation treatment process with aluminum electrodes for treatment of a synthetic wastewater containing C.I. Reactive Red 198 in batch reactor was studied."nMaterial and Methods: The experiment conducted in a Plexiglas reactor with a working volume of 2L that equipped with 4 aluminum electrodes. The effects of operating parameters such as voltage, time of reaction, initial dye concentration and interelectrode distance on the color removal efficiency, electrical energy consumption and electrode consumption were investigated."nResults: in the optimum operational condition electrocoagulation, is able to remove color and COD as high as 99.1 and 84.3% in aluminum electrode in 75 minutes at 20 volt and 2 cm interelectrode distance, respectively. Under this condition, operating cost was 2986 rails per cubic meter of treated wastewater. Increase in the interelectrode distance and initial dye concentration,lead to the decrease in efficiency of dye and COD removal.While as the voltage and time of reaction increased, energy consumption, electrode consumption, final pH and color removal, increased too."nConclusion: electrocoagulation process by aluminum electrode is an efficient and suitable method for reactive dye removal from colored wastewater.

  9. Determination of the solid consumption in the transport of sands in sea beds with gold 198

    International Nuclear Information System (INIS)

    The study of the movement of sediments in sea beds, is necessary when one plans to build a port. Among the techniques used for this studies, it is the radiotracer balance that gives an useful estimation of the quantity of sediment that it moves per day and by meter (perpendicular to the displacement). The main objectives of this work are: to) to present the characteristics of the obtaining of the used radiotracer, describing details those used safety measures, b) to describe the handling of the radiotracer and it radiological safety, during the transport and injection in the sea bottom, c) description of the detection way and the used equipment, d) to describe the information processing obtained in the field and finally, e) the estimate of the solid consumption and the determination of the direction and speed of displacement of those sediments in the sea bottom, in front of the Tabasco coast, to be used jointly with the information obtained by means of other techniques so that one can make a good planning of the operations of dredging during the construction and later on the maintenance of the Dos Bocas marine terminal. The first step is to obtain the radiotracer that in this case was sand of uniform grain metric, marked superficially with Gold-198. The second step is to transport the sand to the place of interest, to place it in the injection equipment and to deposit it in the sea bottom. The third step is to detect the radiotracer in the sea bed, from a craft that drags a sled, which takes mounted a scintillation detector of sodium iodide activated with thallium NaI(Tl) (probe). The fourth step is to process the field information and to obtain the corresponding results. (Author)

  10. Usefulness of 198Au grain implants in the treatment of oral and oropharyngeal cancer

    International Nuclear Information System (INIS)

    A series of 177 patients with squamous cell carcinoma of the oral cavity and oropharynx were treated with 198Au grain (gold grain) implants. Sites of the lesion included the tongue, mouth floor, buccal mucosa and oropharynx, especially the soft palate and faucial arch. Three-fourths of the patients were treated in combination with prior external beam irradiation. A permanent implant dose (total decay) of 80-90 Gy was given in the form of gold grains alone and in combination with an external dose of no more than 30 Gy, and 60-70 Gy, total decay, was given after an external dose greater than 30 Gy. The 2-year recurrence-free rate was 86.2 percent in the case of T1N0, 72.6 percent in T2N0 and 72.2 percent in T3N0. The difference in the results of implant therapy alone and combined therapy was not significant. Late complications were minimal after grain implantation alone, and when used in combination, less than 70 mCi of grain activity after a 40 Gy external dose did not seem to be a serious hazard with respect to bone damage except in the case of cancer of the mouth floor. Gold grain implants were useful and easily applied under local anesthesia to early or super-ficial lesions at sites where a rigid linear source could not be used. Exposure of the radiology staff was only 5-10 mrad in the case of the usual 10-15 (50-75 mCi) implant grains. (author). 12 refs.; 3 figs. ; 5 tabs

  11. Usefulness of sup 198 Au grain implants in the treatment of oral and oropharyngeal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Horiuchi, Junichi; Shibuya, Hitoshi; Matsumoto, Satoru; Hoshina, Masao; Suzuki, Soji (Tokyo Medical and Dental Univ. (Japan). School of Medicine); Takeda, Masamune (Tokyo Medical and Dental Univ. (Japan). School of Dentistry)

    1991-05-01

    A series of 177 patients with squamous cell carcinoma of the oral cavity and oropharynx were treated with {sup 198}Au grain (gold grain) implants. Sites of the lesion included the tongue, mouth floor, buccal mucosa and oropharynx, especially the soft palate and faucial arch. Three-fourths of the patients were treated in combination with prior external beam irradiation. A permanent implant dose (total decay) of 80-90 Gy was given in the form of gold grains alone and in combination with an external dose of no more than 30 Gy, and 60-70 Gy, total decay, was given after an external dose greater than 30 Gy. The 2-year recurrence-free rate was 86.2 percent in the case of T{sub 1}N{sub 0}, 72.6 percent in T{sub 2}N{sub 0} and 72.2 percent in T{sub 3}N{sub 0}. The difference in the results of implant therapy alone and combined therapy was not significant. Late complications were minimal after grain implantation alone, and when used in combination, less than 70 mCi of grain activity after a 40 Gy external dose did not seem to be a serious hazard with respect to bone damage except in the case of cancer of the mouth floor. Gold grain implants were useful and easily applied under local anesthesia to early or super-ficial lesions at sites where a rigid linear source could not be used. Exposure of the radiology staff was only 5-10 mrad in the case of the usual 10-15 (50-75 mCi) implant grains. (author). 12 refs.; 3 figs. ; 5 tabs.

  12. The clinical application of radioactive colloidal gold Au-198 in pelvic lymphoscanning

    International Nuclear Information System (INIS)

    It is important to know the possible cancer dissemination upon pelvic lymph nodes not only for the determination of the therapeutic plan of the cancer of the uterine cervix and other pelvic neoplasm but also for determination of their prognosis. The radioactive pelvic lymph node scanning has been practised to detect the possible metastatic malignancy involving pelvic lymph node. When an intradermal or subcutaneous injection of radioactive colloidal gold-198 is made it flows through the lymphatic channels to the regional lymph nodes. The localization of the colloidal particle in the lymph nodes depends on the lymph node integrity and the patency of the lymphatic channels. The flow of the colloid through the lymphatics may be blocked or slowed by lymph nodes that are invaded or replaced by tumor tissue. In order to investigate the diagnostic potential of the slowing of the flow of the colloidal particle in the lymphatic channel, the authors measured the disappearing rate of the radioactivity injected into the inter-digital soft tissue of patient's feet and it was found that there is considerable delaying in the clearing of the radioactivity from the injected site in the case of those who showed abnormal pelvic lymph nodes scanning. The authors found that more than 85% of injected radioactivity remaining at the site of injection 24 hours after injection should be considered to be abnormal, and the difference more than 15% in the remaining rate of radioactivity between the right and left foot indicates some abnormality in the pelvic lymphnodes. Therefore the authors advocated the radioactivity disappearing test could be practised as a co-screening test with routine pelvic lymphoscanning or be performed as a independent screening test to detect a possible malignant involvement of the pelvic lymph nodes

  13. Letrozole compared with tamoxifen for elderly patients with endocrine-responsive early breast cancer: the BIG 1-98 trial

    DEFF Research Database (Denmark)

    Crivellari, D.; Sun, Z.; Coates, A.S.;

    2008-01-01

    PURPOSE: To explore potential differences in efficacy, treatment completion, and adverse events (AEs) in elderly women receiving adjuvant tamoxifen or letrozole for five years in the Breast International Group (BIG) 1-98 trial. METHODS: This report includes the 4,922 patients allocated to 5 years...... of letrozole or tamoxifen in the BIG 1-98 trial. The median follow-up was 40.4 months. Subpopulation Treatment Effect Pattern Plot (STEPP) analysis was used to examine the patterns of differences in disease-free survival and incidences of AEs according to age. In addition, three categoric age groups...... results: Letrozole significantly improved disease-free survival (DFS), the primary end point, compared with tamoxifen. Elderly patients were less likely to complete trial treatment, but at rates that were similar in the two treatment groups. The incidence of bone fractures, observed more often in the...

  14. COMBINED TREATMENT OF 198 CASES OF INSOMNIA WITH ACUPUNCTURE OF BODY ACUPOINTS PLUS PELLET PRESSING OF OTOPOINTS

    Institute of Scientific and Technical Information of China (English)

    李兰敏; 张立夫; 王丹

    2001-01-01

    Objective: To observe the therapeutic effect of acupuncture of body acupoints plus otopoint pelletpressing for treatment of insomnia. Methods: A total of 198 cases of insomnia patients were observed. Straight inserted the filiform needles into Shenmen (HT 7), Neiguan (PC 6), Zhaohai (KI 6) and Zusanli (ST 36) and manipulated the needles with uniform reinforcing-reducing method, then otopoints as Ershenmen (MA-TF 1 ), Shen (MA-SC), Gan (MA-SC 5), etc. were stimulated by pressing the stuck vaccaria seeds. Ten treatments were considered as a therapeutic course. Results: Of the 198 cases, 65 (32%) were cured, 76 (38%) had remarkable improvement, 53 (26%) had improvement and 4 (2%) had no effect, with the total effective rate being 97% Conclusion:Acupuncture of body acupoints plus otopoint pellet pressing works well in treatment of insomnia.

  15. Intrathecal application of 198Au-colloid in children suffering from leukemia and non-Hodgkin's disease

    International Nuclear Information System (INIS)

    26 children suffering from acute leukemia and non-Hodgkin lymphoma (group 1) received intrathecal Au-198-colloid injections as a prophylactic measure against central nervous system (CNS) relapses. No primary CNS relapses were observed in the period from 1 Sep. 1974 to 31 Oct. 1978. Two children were taken ill at the same time with meningosis leucaemica in the first and second relapse, respectively. Four children (group 2) were treated with Au-198-colloid after overcoming a meningosis leucaemica. It was not possible to prevent another CNS relapse in all four patients of this group. Clinical status, liquor tests and EEG examinations carried out after the therapy showed good tolerance of the gold colloid. (author)

  16. ramR Mutations Affecting Fluoroquinolone Susceptibility in Epidemic Multidrug-Resistant Salmonella enterica Serovar Kentucky ST198

    OpenAIRE

    Axel eCloeckaert

    2013-01-01

    A screening for non-target mutations affecting fluoroquinolone susceptibility was conducted in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198. Among a panel of representative isolates (n=30), covering the epidemic, only three showed distinct mutations in ramR resulting in enhanced expression of genes encoding the AcrAB-TolC efflux system and low increase in ciprofloxacin MIC. No mutations were detected in other regulatory regions of this efflux system. Ciprofloxacin r...

  17. ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198

    OpenAIRE

    Baucheron, Sylvie; Le Hello, Simon; Doublet, Benoît; Giraud, Etienne; Weill, François-Xavier; Cloeckaert, Axel

    2013-01-01

    International audience A screening for non-target mutations affecting fluoroquinolone susceptibility was conducted in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198. Among a panel of representative isolates (n = 27), covering the epidemic, only three showed distinct mutations in ramR resulting in enhanced expression of genes encoding the AcrAB-TolC efflux system and low increase in ciprofloxacin MIC. No mutations were detected in other regulatory regions of this ef...

  18. ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198

    OpenAIRE

    2013-01-01

    A screening for non-target mutations affecting fluoroquinolone susceptibility was conducted in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198. Among a panel of representative isolates (n = 27), covering the epidemic, only three showed distinct mutations in ramR resulting in enhanced expression of genes encoding the AcrAB-TolC efflux system and low increase in ciprofloxacin MIC. No mutations were detected in other regulatory regions of this efflux system. Ciprofloxacin...

  19. Structure of the bipolar flow and molecular cloud associated with the Herbig Ae/Be star LkHα 198

    International Nuclear Information System (INIS)

    Observations of CO outflow and a dense molecular cloud associated with the Herbig Ae/Be star LkHα 198 have been carried out at various molecular lines with high spatial resolution. The results show that the bipolar outflow, known as a well-collimated sample, is highly asymmetric. The physical parameters of this outflow are redetermined along with a discussion concerning its driving mechanism. Secondly, dense condensations around the star reveal many different distributions in molecular lines of 13CO, HCO+, HCN, and CS. The anticorrelation between HCO+ and HCN condensations is remarkable among currently observed clouds, for which different molecular species generally show similar distributions. The HCO+ and CS condensations show velocity gradients suggestive of rotation around the star. The structures of the CO bipolar flow and of the molecular condensations strongly support the adoption of LkHα 198 as being the driving source of the outflow, rather than the nearby luminous variable V376 Cas. Finally, the stellar activities of LkHα 198 are briefly considered in connection with the variable and inhomogeneous nature of the outflow and dense molecular condensations around the star. (author)

  20. Endolymphatic irradiation with 198Au and 32P as immunosuppression in renal transplantion. The effect on hematologic and immunobiologic parameters

    International Nuclear Information System (INIS)

    Twenty patients with end stage renal disease awaiting kidney transplantation were treated with radioisotopes in an investigation of the immunosuppressive effect of endolymphatic irradiation. Twelve patients received 198Au and eight were treated with 32P. The isotopes were injected into lymph vessels in the foot and localized in the pelvic lymph nodes with only an extremely small release to the blood and urine. The doses given were 2-7.5 mCi 198Au or 0.4-1.5 mCi 32P. The accumulated dose in the lymph nodes was calculated to be approximately 35,000 rad for 198Au and approximately 150,000 rad for 32P. The blood activity was 1.0-0.2 rad. The dose to a kidney graft was calculated to be approximately 20 rad, and the dose to a lymphocyte in the first 6 hr after injection approximately 1500 rad. The results obtained were lymphocytopenia and a depressed immune response measured with blast transformation tests after stimulation with mitogens, antigens, and allogene cells in mixed lymphocyte culture. No effect was observed on bone marrow, immunoglobulins, complements, liver enzymes, spleen-size, or liver size. A small transient fall in erythrocyte count was seen but otherwise no side effects were demonstrated. Thus, the treatment given, with maximum permissible doses, had an effect on the immune response, but as this effect only lasts for a few weeks the treatment has little practical applicability in kidney transplantation

  1. Preparation of magnetic composite based on zinc oxide nanoparticles and chitosan as a photocatalyst for removal of reactive blue 198

    Science.gov (United States)

    Nguyen, Van Cuong; Giang Nguyen, Ngoc Lam; Hue Pho, Quoc

    2015-09-01

    In this study a novel magnetic composite used as a photocatalyst with combination of zinc oxide nanoparticles and chitosan (ZnO/Fe3O4/CS) was synthesized by a simple co-precipitation method. The role of the prepared magnetic nanocomposite is to improve the removal efficiency of textile dye due to the photocatalytic activity of zinc oxide nanoparticles and reusable capacity of Fe3O4 magnetic nanoparticles. Constituents and structure properties of ZnO/Fe3O4/CS were investigated by scanning electron microscopy (SEM), x-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). Magnetic property of the prepared composite was determined by vibrating sample magnetometer (VSM). The results demonstrated that ZnO/Fe3O4/CS nanocomposite dramatically improved the removal efficiency of reactive blue 198 dye (RB198) with high photocatalytic activity and easy separation by a permanent magnet. In addition, the photocatalytic activity of the prepared composite was also performed under different parameters such as contact time, initial pH, the amount of composite and initial concentration of RB198. Interestingly, ZnO/Fe3O4/CS nanocomposite still showed high removal efficiency after recycling three times and performed in a real textile dyeing wastewater.

  2. Facile fabrication of ZnLa0.02Fe1.98O4/PPy and application in water treatment

    International Nuclear Information System (INIS)

    Graphical abstract: A core–shell structure of magnetic ZnLa0.02Fe1.98O4/PPy nanoparticles was facilely fabricated at room temperature. The ZnLa0.02Fe1.98O4/PPy shows higher adsorption rate and capacity in removal of anionic organic dye, methyl orange (MO), from water than that of ZnLa0.02Fe1.98O4. -- Highlights: • A core–shell structure of ZnLa0.02Fe1.98O4/PPy nanoparticles was facilely fabricated at room temperature. • The saturation magnetization and electric conductivity of the sample are 26.0 ± 0.2 emu/g, 169 ± 2 S/cm, respectively. • The ZnLa0.02Fe1.98O4/PPy shows higher adsorption rate and capacity in removal of anionic organic dye, methyl orange (MO), from water than that of ZnLa0.02Fe1.98O4. -- Abstract: A core–shell structure of magnetic ZnLa0.02Fe1.98O4/Polypyrrole (PPy) nanoparticles (NPs) was facilely fabricated at room temperature, in which FeCl3 was used as an initiator. Dodecyl sulfate anions (SDS) were adsorbed onto the outer surface of the ZnLa0.02Fe1.98O4 through the charge compensation. The absorbed SDS induced the adhesion of the PPy to the surface of the ZnLa0.02Fe1.98O4 along with polymerization. The as-prepared composite shows better performance in removal of pollutants like methyl orange (MO) from water by adsorption than that of the ZnLa0.02Fe1.98O4. The adsorption experiments indicated that the adsorption was divided into two processes. The maximum adsorption capacity for MO was determined to be 76.34 mg/g. The experimental data fit the Langmuir model implying the single layer adsorption. The adsorption process was described by the pseudo-second-order kinetic model. The adsorption of MO onto the ZnLa0.02Fe1.98O4/PPy was exothermic process, and the randomness decreased at the process. To decrease experimental temperature is suitable for the adsorption of MO onto the ZnLa0.02Fe1.98O4/PPy

  3. Analysis of the common causes of dyspnea in 198 uremic patients%198例尿毒症患者呼吸困难常见病因分析

    Institute of Scientific and Technical Information of China (English)

    何翠嫦; 马晓燕; 韦启麒

    2014-01-01

    目的:探讨尿毒症患者呼吸困难常见病因,以指导抢救及预防措施。方法对住院的198例尿毒症出现呼吸困难患者的临床资料进行回顾性分析。结果198例均予加强血液透析3次/周,同时结合其他内科治疗,196例好转,2例死亡。结论尿毒症患者呼吸困难常见原因为急性左心衰、重度代谢性酸中毒、急性左心衰合并重度代谢性酸中毒及大量胸腔积液等,其危险因素可能为血液透析不充分、高血压控制不佳、贫血、代谢性酸中毒、感染等。%Objective To explore the common causes of dyspnea in uremic patients in order to provide the guidance for making treament and prevention measures .Methods Clinical data of 198 uremic inpatients with dysp-nea were analyzed retrospectively .Results After strengthening hemodialysis three times a week and using other inter-nal medicine treatment, The improvement was obtained in 196 patients, 2 patients died.Conclusion The common causes of dyspnea in uremic patients included acute heart failure , seriously metabolic acidosis , acute heart failure combined with seriously metabolic acidosis , massive pleural effusions and so on .The risk factors included inadeguate hemodialysis, the hypertension not being well controlled , anemia, metabolic acidosis, infection and so on.

  4. N-benzyladriamycin-14-valerate (AD 198) exhibits potent anti-tumor activity on TRAF3-deficient mouse B lymphoma and human multiple myeloma

    International Nuclear Information System (INIS)

    TRAF3, a new tumor suppressor identified in human non-Hodgkin lymphoma (NHL) and multiple myeloma (MM), induces PKCδ nuclear translocation in B cells. The present study aimed to evaluate the therapeutic potential of two PKCδ activators, N-Benzyladriamycin-14-valerate (AD 198) and ingenol-3-angelate (PEP005), on NHL and MM. In vitro anti-tumor activities of AD 198 and PEP005 were determined using TRAF3-/- mouse B lymphoma and human patient-derived MM cell lines as model systems. In vivo therapeutic effects of AD 198 were assessed using NOD SCID mice transplanted with TRAF3-/- mouse B lymphoma cells. Biochemical studies were performed to investigate signaling mechanisms induced by AD 198 or PEP005, including subcellular translocation of PKCδ. We found that AD 198 exhibited potent in vitro and in vivo anti-tumor activity on TRAF3-/- tumor B cells, while PEP005 displayed contradictory anti- or pro-tumor activities on different cell lines. Detailed mechanistic investigation revealed that AD 198 did not affect PKCδ nuclear translocation, but strikingly suppressed c-Myc expression and inhibited the phosphorylation of ERK, p38 and JNK in TRAF3-/- tumor B cells. In contrast, PEP005 activated multiple signaling pathways in these cells, including PKCδ, PKCα, PKCϵ, NF-κB1, ERK, JNK, and Akt. Additionally, AD198 also potently inhibited the proliferation/survival and suppressed c-Myc expression in TRAF3-sufficient mouse and human B lymphoma cell lines. Furthermore, we found that reconstitution of c-Myc expression conferred partial resistance to the anti-proliferative/apoptosis-inducing effects of AD198 in human MM cells. AD 198 and PEP005 have differential effects on malignant B cells through distinct biochemical mechanisms. Our findings uncovered a novel, PKCδ-independent mechanism of the anti-tumor effects of AD 198, and suggest that AD 198 has therapeutic potential for the treatment of NHL and MM involving TRAF3 inactivation or c-Myc up-regulation

  5. Biodistribution of a potential chemotherapeutic, dinuclearbisphosphinogold(I) dithiocarbamate, as determined by its 198Au radiolabelled analogue

    International Nuclear Information System (INIS)

    Dinuclearbisphosphinogold(I) dithiocarbamato, BPDTC, was previously found to have antitumour activity in vitro. 198Au radiolabelled BPDTC (radiochemical yield of 70 ± 6 % and radiochemical purity of >95 %) was used to determine its in vivo biodistribution in Sprague-Dawley rats. Gamma scintigraphs were performed over a period of 48 h and final radioactivity measurements of harvested organs of the test animals after termination was performed at 2, 4 and 48 h. The study successfully showed the biodistribution of the gold complex, with the highest uptake of the compound being observed in the lungs, liver and spleen. (author)

  6. Methodology of meningosis 'prophylaxis' with gold 198 colloids of leukemias and non-Hodgkin lymphomas in children

    International Nuclear Information System (INIS)

    The methodology of CNS 'prophylaxis' with gold 198 colloids of acute leukemias and non-Hodgkins lymphomas in children is dealt with in detail. The following problems have been taken into consideration: determination of the energy dose in the cerebrospinal fluid, activity and particle size of the radiogold colloid, volume of injection, additional paraclinical examinations, measures in case of insufficient distribution and radiation protection measurements. The role of CNS 'prophylaxis' in therapy plans for acute leukemias and non-Hodgkins lymphomas is discussed. Pecularities to be considered are explained. In conclusion the possibility of telecobalt irradiation after insufficient radiogold distribution is discussed. (author)

  7. 基于SC28L198的多串口服务器设计%Design of Multiple Serial Port Network Gateway Based on SC28L198

    Institute of Scientific and Technical Information of China (English)

    沈克宇; 林锦泸; 李志俊; 赵田芳; 张蕾

    2011-01-01

    Many types of equipment do not have network interface. The goal of this thesis is to solve the access to this kind of equipment. The embedded system constructed on basis of ARM7 Coxtex- M3 MCU LM8962 and 8 -channel UART was expanded by SC28L198. The multi- serial port device through TCP/IP protocol was developed under μC/OS- Ⅱ operation system. The system can provide remote data via Ethernet for eight serial devices simultaneously,which provides conditions for the devices with the serial communication interface in the network control and realizes the capability of computer remote monitoring.%针对许多设备不具备网络接口的问题,以ARM7 Cortex-M3处理器IM8962为核心构建嵌入式系统,利用SC28L198芯片扩展8个串口,完成基于μC/OS-Ⅱ操作系统和TCP/IP协议的多串口服务器设计.该系统能够同时为8个串口设备提供以太网远程数据传输,为具有串行通信接口设备的网络控制提供了条件,实现了计算机远程监控.

  8. Application of gold-198 in investigation of technological processes in cellulose and paper industry and in production of combined forage

    International Nuclear Information System (INIS)

    To label cellulose fibers and sawdust in investigation of acting installations for production of cellulose and semicellulose, gold-198 was used. The aim of investigation was to determine time of material's transfer in the cellulose production shop from the boiler to the outlet from washer and in the semicellulose production shop from the feeding bunker to refiners. Stable labelling of the cellulose fibers and sawdust has been gained, which permitted successfully to perform investigations of two installations in spite of high temperature and pressure and aggressive medium. Gold-198 is also a good indicator in investigations of technological lines of feed mills. After labelling of one of the main components of fodder mixture, it is introduced into mixer in the proportion used in the production for mixing. It is possible to trace process of mixing either by means of continious registering of by means of sampling. As a result of investigations, optimal time of mixing, segregation processes influence of the factory transport and intershop idle stand on the homogenity of product for factories with different equipment, can be determined

  9. Experimental investigation with 198Au colloid as to lymph communications between the retrobulbar space and the thyroid gland

    International Nuclear Information System (INIS)

    The problem of a direct connection of lymph drainage between the retrobulbar space and the thyroid gland was examined using the lymphotropic radioactive tracer 198Au colloid. Twelve rabbits were examined. Six animals were injected with 50 μCi198Au colloid into the right thyroid lobe and six animals into the right retrobulbar space. Distribution and total bodyradioactivity was measured in vivo using a scintillation camera with a computer. After 6 hrs tissue specimens of different organs were measured in a well-counter. The discharge of activity from the thyroid after 6hrs was significantly higher than that from the retrobulbar space (63% versus 33.5%). This was probably due to a higher vascularisation and to a higher degree of lymph drainage of the thyroid. The lymph drainage of the thyroid gland as well as of the retrobulbar space occured mainly via the lymphonodi cerv.proff. No significant activity was found in the retrobulbar space after thyroid injection or in the thyroid after retrobulbar injection. It may be concluded from these results that there are not direct lymph connections between the retrobulbar space and the thyroid gland. However, indirect communications via the deep cervical lymph nodes cannot be excluded in the event of reverse lymph flow. (orig.)

  10. Fabrication of Fe-doped TiO2 nanoparticles and investigation of photocatalytic decolorization of reactive red 198 under visible light irradiation.

    Science.gov (United States)

    Moradi, Halimeh; Eshaghi, Akbar; Hosseini, Seyed Rahman; Ghani, Kamal

    2016-09-01

    In this research, Fe-doped TiO2 nanoparticles with various Fe concentrations (0. 0.1, 1, 5 and 10wt%) were prepared by a sol-gel method. Then, nanoparticles were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray analysis (EDX), BET surface area, photoluminescence (PL) spectroscopy and UV-vis diffuse reflectance spectroscopy (DRS). The photocatalytic activity of the nano-particles was evaluated through degradation of reactive red 198 (RR 198) under UV and visible light irradiations. XRD results revealed that all samples contained only anatase phase. DRS showed that the Fe doping in the titania induced a significant red shift of the absorption edge and then the band gap energy decreased from 3 to 2.1eV. Photocatalytic results indicated that TiO2 had a highest photocatalytic decolorization of the RR 198 under UV irradiation whereas photocatalytic decolorization of the RR 198 under visible irradiation increased in the presence of Fe-doped TiO2 nanoparticles. Among the samples, Fe-1wt% doped TiO2 nanoparticles showed the highest photocatalytic decolorization of RR198 under visible light irradiation. PMID:27150776

  11. Molecular risk assessment of BIG 1-98 participants by expression profiling using RNA from archival tissue

    Directory of Open Access Journals (Sweden)

    Giobbie-Hurder Anita

    2010-02-01

    Full Text Available Abstract Background The purpose of the work reported here is to test reliable molecular profiles using routinely processed formalin-fixed paraffin-embedded (FFPE tissues from participants of the clinical trial BIG 1-98 with a median follow-up of 60 months. Methods RNA from fresh frozen (FF and FFPE tumor samples of 82 patients were used for quality control, and independent FFPE tissues of 342 postmenopausal participants of BIG 1-98 with ER-positive cancer were analyzed by measuring prospectively selected genes and computing scores representing the functions of the estrogen receptor (eight genes, ER_8, the progesterone receptor (five genes, PGR_5, Her2 (two genes, HER2_2, and proliferation (ten genes, PRO_10 by quantitative reverse transcription PCR (qRT-PCR on TaqMan Low Density Arrays. Molecular scores were computed for each category and ER_8, PGR_5, HER2_2, and PRO_10 scores were combined into a RISK_25 score. Results Pearson correlation coefficients between FF- and FFPE-derived scores were at least 0.94 and high concordance was observed between molecular scores and immunohistochemical data. The HER2_2, PGR_5, PRO_10 and RISK_25 scores were significant predictors of disease free-survival (DFS in univariate Cox proportional hazard regression. PRO_10 and RISK_25 scores predicted DFS in patients with histological grade II breast cancer and in lymph node positive disease. The PRO_10 and PGR_5 scores were independent predictors of DFS in multivariate Cox regression models incorporating clinical risk indicators; PRO_10 outperformed Ki-67 labeling index in multivariate Cox proportional hazard analyses. Conclusions Scores representing the endocrine responsiveness and proliferation status of breast cancers were developed from gene expression analyses based on RNA derived from FFPE tissues. The validation of the molecular scores with tumor samples of participants of the BIG 1-98 trial demonstrates that such scores can serve as independent prognostic

  12. Molecular risk assessment of BIG 1-98 participants by expression profiling using RNA from archival tissue

    International Nuclear Information System (INIS)

    The purpose of the work reported here is to test reliable molecular profiles using routinely processed formalin-fixed paraffin-embedded (FFPE) tissues from participants of the clinical trial BIG 1-98 with a median follow-up of 60 months. RNA from fresh frozen (FF) and FFPE tumor samples of 82 patients were used for quality control, and independent FFPE tissues of 342 postmenopausal participants of BIG 1-98 with ER-positive cancer were analyzed by measuring prospectively selected genes and computing scores representing the functions of the estrogen receptor (eight genes, ER-8), the progesterone receptor (five genes, PGR-5), Her2 (two genes, HER2-2), and proliferation (ten genes, PRO-10) by quantitative reverse transcription PCR (qRT-PCR) on TaqMan Low Density Arrays. Molecular scores were computed for each category and ER-8, PGR-5, HER2-2, and PRO-10 scores were combined into a RISK-25 score. Pearson correlation coefficients between FF- and FFPE-derived scores were at least 0.94 and high concordance was observed between molecular scores and immunohistochemical data. The HER2-2, PGR-5, PRO-10 and RISK-25 scores were significant predictors of disease free-survival (DFS) in univariate Cox proportional hazard regression. PRO-10 and RISK-25 scores predicted DFS in patients with histological grade II breast cancer and in lymph node positive disease. The PRO-10 and PGR-5 scores were independent predictors of DFS in multivariate Cox regression models incorporating clinical risk indicators; PRO-10 outperformed Ki-67 labeling index in multivariate Cox proportional hazard analyses. Scores representing the endocrine responsiveness and proliferation status of breast cancers were developed from gene expression analyses based on RNA derived from FFPE tissues. The validation of the molecular scores with tumor samples of participants of the BIG 1-98 trial demonstrates that such scores can serve as independent prognostic factors to estimate disease free survival (DFS) in

  13. Treatment of cultured glioma cells with the EGFR-TKI gefitinib (''Iressa'', ZD1839) increases the uptake of astatinated EGF despite the absence of gefitinib-mediated growth inhibition

    International Nuclear Information System (INIS)

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib (''Iressa'', ZD1839), a reversible growth inhibitor of EGFR-expressing tumour cells, has been shown to enhance the antitumour effect of ionising radiation, and also to increase the uptake of radioiodinated EGF. Thus, combination of gefitinib treatment and radionuclide targeting is an interesting option for therapy of brain tumours that are difficult to treat with conventional methods. The aim of this study was to evaluate how pre-treatment with gefitinib affects binding of astatinated EGF (211At-EGF) to cultured glioma U343 cells, which express high levels of EGFR. The growth of U343 cells in the presence of gefitinib was investigated, and it was found that gefitinib does not significantly inhibit the growth of these cells. Nevertheless, the uptake of 211At-EGF in U343 cells was markedly increased (up to 3.5 times) in cells pre-treated with gefitinib (1 μM). This indicates that a combination of gefitinib treatment and radionuclide targeting to EGFR might be a useful therapeutic modality, even for patients who do not respond to treatment with gefitinib alone. (orig.)

  14. Fission excitation function for 19F + 194,196,198Pt at near and above barrier energies

    Directory of Open Access Journals (Sweden)

    Singh Varinderjit

    2015-01-01

    Full Text Available Fission excitation functions for 19F + 194,196,198Pt reactions populating 213,215,217Fr compound nuclei are reported. Out of these three compound nuclei, 213Fr is a shell closed (N=126 compound nucleus and the other two are away from the shell closure. From a comparison of the experimental fission cross-sections with the statistical model predictions, it is observed that the fission cross-sections are underestimated by the statistical model predictions using shell corrected finite range rotating liquid drop model (FRLDM fission barriers. Further the FRLDM fission barriers are reduced to fit the fission cross-sections over the entire measured energy range.

  15. Malignant melanoma of the choroid: treatment with episcleral /sup 198/Au plaque and xenon-arc photocoagulation

    Energy Technology Data Exchange (ETDEWEB)

    Moura, R.A.; McPherson, A.R.; Easley, J.

    1985-02-01

    A method of treatment for posteriorly located malignant melanomas of the choroid is reviewed. Twenty-six patients have been treated either by radioactive gold (/sup 198/Au) seed radiation plaque, alone or in combination with postradiation xenon-arc photocoagulation. Success, defined as the preservation of the globe with tumor ablated or regressed, was achieved in 92.3% of the treated eyes. These patients have been followed from 1 to 8.5 years, with an average follow-up of 44.84 months. Fifteen out of 26 patients (57.69%) had a final visual acuity of 20/50 or better. The main complications were radiation retinopathy (19.2%) and cystoid macular edema (19.2%). There were two enucleations, one after 29 months and one after 24 months following treatment.

  16. Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study

    DEFF Research Database (Denmark)

    Ravn-Haren, Gitte; Olsen, A.; Tjonneland, A.;

    2006-01-01

    -control study was to determine whether GPX1 Pro198Leu and glutathione peroxidase (GPX) activity in prospectively collected blood samples are associated with breast cancer risk among postmenopausal women and whether GPX activity levels are associated with other known breast cancer risk factors. We matched 377...... female breast cancer cases with 377 controls all nested within the prospective 'Diet, Cancer and Health' study of 57 000 Danes. Carriers of the variant T-allele of GPX1 Pro198Leu were at 1.43-fold higher risk of breast cancer compared with non-carriers (95% CI = 1.07-1.92). Pre-diagnostic GPX activity......Breast cancer may be related to oxidative stress. Breast cancer patients have been reported to have lower antioxidant enzyme activity than healthy controls and the polymorphism GPX1 Pro198Leu has been associated with risk of lung and breast cancer. The purpose of the present nested case...

  17. Obesity and risk of recurrence or death after adjuvant endocrine therapy with letrozole or tamoxifen in the breast international group 1-98 trial

    DEFF Research Database (Denmark)

    Ewertz, Marianne; Gray, Kathryn P; Regan, Meredith M;

    2012-01-01

    To examine the association of baseline body mass index (BMI) with the risk of recurrence or death in postmenopausal women with early-stage breast cancer receiving adjuvant tamoxifen or letrozole in the Breast International Group (BIG) 1-98 trial at 8.7 years of median follow-up.......To examine the association of baseline body mass index (BMI) with the risk of recurrence or death in postmenopausal women with early-stage breast cancer receiving adjuvant tamoxifen or letrozole in the Breast International Group (BIG) 1-98 trial at 8.7 years of median follow-up....

  18. Cognitive function in postmenopausal women receiving adjuvant letrozole or tamoxifen for breast cancer in the BIG 1-98 randomized trial

    OpenAIRE

    Phillips, Kelly Anne; Ribi, Karin; Sun, Zhuoxin; Stephens, Alisa; Thompson, Alastair; Harvey, Vernon; Thürlimann, Beat; Cardoso, Fatima; Pagani, Olivia; Coates, Alan S.; Goldhirsch, Aron; Price, Karen N.; Gelber, Richard D; Bernhard, Jürg

    2010-01-01

    Cognitive function in postmenopausal women receiving letrozole or tamoxifen as adjuvant endocrine treatment was compared during the fifth year of treatment in a substudy of the BIG 1-98 trial. In BIG 1-98 patients were randomized to receive adjuvant A) 5-years tamoxifen, B) 5-years letrozole, C) 2-years tamoxifen followed by 3-years letrozole, or D) 2-years letrozole followed by 3-years tamoxifen. The primary comparison was the difference in composite score for patients taking letrozole (B+C;...

  19. Yield of isomers in 76Ge (635 MeV) + 198Pt deep-inelastic collision and their dependence on projectiles (74,76Ge) and beam energies (635,550 MeV)

    International Nuclear Information System (INIS)

    We report the yields and distribution of ns-μs isomers produced in 76Ge (635 MeV) + 198Pt deep-inelastic collision. The population yields of isomers evaluated for individual channel and compared with the relevant yields produced in 76Ge (635 MeV) + 198Pt and 74Ge (550 MeV) + 198Pt reaction. These comparisons reflect how isomer yield depends on beam energies and projectile mass in deep-inelastic collisions. (author)

  20. 南宁地区琼脂糖凝胶电泳产前筛查地贫16 198例结果分析%Analysis on 16 198 cases prenatal screen of Thalassaemia using agarose electrophoresis

    Institute of Scientific and Technical Information of China (English)

    阙婷; 李东明

    2012-01-01

    目的 评价琼脂糖凝胶电泳在产前地中海贫血(地贫)筛查中的价值.方法 采用琼脂糖凝胶电泳对16 198例外周血或胎儿脐血进行Hb分析,其中4 242例进行地贫基因检测.结果 16 198例检出β地贫1390例,异常Hb 495例,异常Hb病133例,异常检出率12.46%.与基因检测结果比较,电泳筛查β地贫、HbH病和HbCS的灵敏度和特异度为93.57%和96.25%、100%和69.74%及99.64%和62.52%,以HbA2≤2.45%、2.65%筛查α1、α2地贫的灵敏度和特异度分别为68.44%和64.11%、63.81%和52.79%.电泳筛查胎儿脐血α地贫的灵敏度和特异度为89.94%和98.58%,其中对中间型、重型α地贫筛查灵敏度和特异性均为100%.结论 广西地区地贫发生率较高,琼脂糖凝胶电泳筛查β地贫的灵敏度和特异度较好,能准确的筛出胎儿脐血中间型、重型α地贫;在胎儿脐血和外周血中筛查轻型和静止型α地贫的灵敏度和特异度差异较大,且胎儿脐血优于外周血.%Objective: To evaluate the application of agarose electrophoresis in the prenatal screen of thalassemia (thal). Methods: Agarose electrophoresis was used to perform hemoglobin (Hb) electrophoresis for 16 918 cases. 4 242 samples were further examined by DNA analysis. Results; Among 16 198 cases, 1 390 cases of (3 thal, 4S9 cases of abnormal hemoglobin and 133 cases of abnormal hemoglobin disease were detected, and the abnormal rate was 12. 46% . The sensitivity and specificity that agarose electrophoresis consistent with gene diagnoses for β - thal, HbH disease and HbCS were 93. 57% and 96. 25% , 100% and 69. 74% , 99. 64% and 52. 79%. To diagnose α thal 1 and α thal 2 by HbA2≤2. 45% and 2. 65% , the sensitivity and specificity were 68. 44% and 64. 1 J% , 63. 81% and 52. 79%. The sensitivity and specificity of screening α thai in prenatal umbilical cord blood were 89. 94% and 98. 58% , and the sensitivity and specificity of agarose electrophoresis

  1. Draft Genome Sequences of Listeria monocytogenes Serotype 4b Strains 944 and 2993 and Serotype 1/2c Strains 198 and 2932

    Science.gov (United States)

    Casey, Aidan; Fox, Edward M.; Leong, Dara; Gahan, Cormac G. M.; Jordan, Kieran

    2016-01-01

    Listeria monocytogenes is a foodborne pathogen and the causative agent of listeriosis among humans and animals. The draft genome sequences of L. monocytogenes serotype 4b strains 944 and 2993 and serotype 1/2c strains 198 and 2932 are reported here. PMID:27257200

  2. Proposals and developments in radiation dose selection occurring within ISO/TC/198 intended to address current problems

    International Nuclear Information System (INIS)

    ISO/TC/198 has now been in operation for 8 years during that time one Standard and a number of Technical reports (TRs) have been published. Except for ISO/TR 13409 these have all been more appropriate to devices manufactured in large numbers. Most of the documents approved so far have already been used in earlier AAMI standards. One item from earlier standards was a method allowing sterilization dose to be validated on the basis of determining the radiation resistance of the bioburden found on devices. This method has value for devices manufactured in small numbers which fail to pass ISO 11137 Method 1. A study was undertaken by a number of Japanese manufactures to assess the radiation resistance of the bioburden, with the intention of calculating a radiation sterilization dose from the information so obtained. The findings of this investigation will be reviewed and proposals for developing a method based on them will be discussed. In recent months a new proposal for the validation of a 25 kGy dose has been promulgated. This proposal, and some of the proposals i will be discussing, make provision for a much higher verification dose than can be used in ISO 11137, Method 1 or its modification found in ISO 13409. (author)

  3. Proposals and developments in radiation dose selection occurring within ISO/TC/198 intended to address current problems

    Energy Technology Data Exchange (ETDEWEB)

    Whitby, J.L. [Department of Microbiology, University of Western Ontario, London, ON (Canada)

    1998-12-31

    ISO/TC/198 has now been in operation for 8 years during that time one Standard and a number of Technical reports (TRs) have been published. Except for ISO/TR 13409 these have all been more appropriate to devices manufactured in large numbers. Most of the documents approved so far have already been used in earlier AAMI standards. One item from earlier standards was a method allowing sterilization dose to be validated on the basis of determining the radiation resistance of the bioburden found on devices. This method has value for devices manufactured in small numbers which fail to pass ISO 11137 Method 1. A study was undertaken by a number of Japanese manufactures to assess the radiation resistance of the bioburden, with the intention of calculating a radiation sterilization dose from the information so obtained. The findings of this investigation will be reviewed and proposals for developing a method based on them will be discussed. In recent months a new proposal for the validation of a 25 kGy dose has been promulgated. This proposal, and some of the proposals i will be discussing, make provision for a much higher verification dose than can be used in ISO 11137, Method 1 or its modification found in ISO 13409. (author)

  4. Effect of N/Z in pre-scission neutron multiplicity for 16,18O+198Pt systems

    International Nuclear Information System (INIS)

    This paper reports the summary of the experimental results of pre-scission neutron multiplicities from four compound nuclei, namely 210,212,214,216Rn, and statistical model analysis of the corresponding data. The compound nuclei 210,212,214,216Rn having N/Z values as 1.441, 1.465, 1.488, 1.511 respectively are populated through the 16,18O+194,198Pt reactions at excitation energies of 50, 61, 71.7 and 79 MeV. The measured neutron multiplicities are further analyzed with the statistical model of nuclear decay where fission hindrance due to nuclear dissipation is considered. The N/Z dependence of the dissipation strength at lowest excitation energy of the compound nuclei suggests shell closure effects. However, such effects are not observed at higher excitations where the variation of the dissipation strength with N/Z does not show any specific trend. The variation of N/Z in fission time scale is also shown. (authors)

  5. Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake.

    Science.gov (United States)

    Cardoso, Bárbara R; Busse, Alexandre L; Hare, Dominic J; Cominetti, Cristiane; Horst, Maria A; McColl, Gawain; Magaldi, Regina M; Jacob-Filho, Wilson; Cozzolino, Silvia M F

    2016-02-01

    Selenoproteins play important roles in antioxidant mechanisms, and are thus hypothesised to have some involvement in the pathology of certain types of dementia. Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are both thought to involve impaired biological activity of certain selenoproteins. Previously, supplementation with a selenium-rich Brazil nut (Bertholletia excelsa) has shown potential in reducing cognitive decline in MCI patients, and could prove to be a safe and effective nutritional approach early in the disease process to slow decline. Here, we have conducted a pilot study that examined the effects of a range of single nucleotide polymorphisms (SNPs) in genes encoding the selenoproteins glutathione peroxidase (GPX1) and selenoprotein P (SEPP) in response to selenium supplementation via dietary Brazil nuts, including selenium status, oxidative stress parameters and GPX1 and SEPP gene expression. Our data suggest that GPX1 Pro198Leu rs1050450 genotypes may differentially affect the selenium status and GPx activity. Moreover, rs7579 and rs3877899 SNPs in SEPP gene, as well as GPX1 rs1050450 genotypes can influence the expression of GPX1 and SEPP mRNA in response to Brazil nuts intake. This small study gives cause for larger investigations into the role of these SNPs in both the selenium status and response to selenium dietary intake, especially in chronic degenerative conditions like MCI and AD. PMID:26661784

  6. Exploring contributions from incomplete fusion in Li,76+209Bi and Li,76+198Pt reactions

    Science.gov (United States)

    Parkar, V. V.; Jha, V.; Kailas, S.

    2016-08-01

    We use the breakup absorption model to simultaneously describe the measured cross sections of complete fusion (CF), incomplete fusion (ICF), and total fusion (TF) in nuclear reactions induced by weakly bound nuclei Li,76 on 209Bi and 198Pt targets. The absorption cross sections are calculated using the continuum discretized coupled channels (CDCC) method with different choices of short-range imaginary potentials to get the ICF, CF, and TF cross sections. It is observed that the cross sections for deuteron ICF / deuteron capture and α ICF / α capture are of similar magnitude, in the case of the 6Li projectile, while the cross sections for the triton ICF / triton capture is more dominant than that of α ICF / α capture in the case of the 7Li projectile. Both these observations are also corroborated by the experimental data. The ratio of ICF to TF cross sections, which defines the value of fusion suppression factor, is found to be in agreement with the data available from the literature. The cross-section ratios of CF/TF and ICF/TF show opposite behavior at below-barrier energies the former decreases while the latter increases as the energy is lowered, which shows the dominance of ICF at below-barrier energies. We have also studied the correlation of the ICF cross sections with the noncapture breakup (NCBU) cross sections as a function of energy, which shows that the NCBU is more significant than ICF at below-barrier energies.

  7. Exploring contributions from incomplete fusion in $^{6,7}$Li+$^{209}$Bi and $^{6,7}$Li+$^{198}$Pt reactions

    CERN Document Server

    Parkar, V V; Kailas, S

    2016-01-01

    We use the breakup absorption model to simultaneously describe the measured cross-sections of the Complete fusion (CF), Incomplete fusion (ICF), and Total fusion (TF) in nuclear reactions induced by weakly bound nuclei $^{6,7}$Li on $^{209}$Bi and $^{198}$Pt targets. The absorption cross-sections are calculated using the Continuum Discretized Coupled Channels (CDCC) method with different choices of short range imaginary potentials to get the ICF, CF and TF cross-sections. It is observed that the cross-sections for deuteron-ICF/deuteron-capture are of similar magnitude as the $\\alpha$-ICF/$\\alpha$-capture, in case of $^{6}$Li projectile, while the cross-sections for triton-ICF/triton-capture is more dominant than $\\alpha$-ICF/$\\alpha$-capture in case of $^{7}$Li projectile. Both these observations are also corroborated by the experimental data. The ratio of ICF to TF cross-sections, which defines the value of fusion suppression factor is found to be in agreement with the data available from the literature. The...

  8. Prevalência de manifestações oculares em 198 pacientes com artrite reumatóide: um estudo retrospectivo Prevalence of ocular manifestation in 198 patients with rheumatoid arthritis: a restrospective study

    Directory of Open Access Journals (Sweden)

    Raphael Guimarães Bettero

    2008-06-01

    Full Text Available OBJETIVO: Estimar a prevalência de manifestações oculares na população local de artrite reumatóide (AR. Estimar se a presença de auto-anticorpos como fator reumatóide (FR e fator antinuclear (FAN influi no aparecimento destas manifestações e se existe associação entre o aparecimento de manifestações oculares e índice funcional do paciente, idade ao diagnóstico e tempo de doença. MÉTODOS: Foram estudados retrospectivamente 198 prontuários de pacientes com AR, acompanhados durante o período de 2003 a 2006. Avaliou-se a prevalência das manifestações oftalmológicas, perfil de auto-anticorpos, dados demográficos e índice funcional de Steinbrock destes pacientes. RESULTADOS: Síndrome de Sjögren secundária apareceu em 12,1% dos pacientes sendo mais comum em mulheres (p=0,049 e em pacientes com maior dano articular (p=0,016. Ceratite ulcerativa e esclerite incidiram em torno de 2% dos pacientes. Fator reumatóide (FR e fator antinuclear (FAN assim como tempo de doença e idade do paciente ao diagnóstico não influíram no aparecimento das manifestações estudadas. CONCLUSÃO: A síndrome de Sjögren secundária é a manifestação ocular mais prevalente em pacientes com AR, sendo mais comum em mulheres e em pacientes com mais disfunção articular.PURPOSE: To study the prevalence of eye manifestations in the local rheumatoid arthritis (RA population, as well as to know if the presence of rheumatoid factor (RF and antinuclear antibodies (ANA affect this profile. To study if there is association between eye manifestations and patient's articular functional index, age at diagnosis and illness duration. METHODS: We reviewed 198 charts of rheumatoid arthritis patients followed-up from 2003 to 2006. They were studied for: prevalence of ophthalmologic manifestations, autoantibody profile, demographic data and Steinbrock's functional index. RESULTS: Secondary Sjögren's syndrome was seen in 12.1% of the patients being more common

  9. 复发性流产社会心理因素研究198例临床分析%Clinical analysis on socio-psychological factors of 198 cases with recurrent abortion

    Institute of Scientific and Technical Information of China (English)

    陈清冉

    2011-01-01

    目的:探讨复发性流产的危险因素,尤其足社会心理因素在复发性流产中的作用.方法:以复发性流产198例孕妇作为病例组,而同期先兆流产165例为对照组进行病例对照研究.采用非条件对数优势回归模型对研究因素进行多因素分析.结果:按α=0.05水平,多次自然流产病例组患病率为90.00%,对照组为49.70%(P<0.01,OR=9.62);社会心理因素病例组患病率为87.37%,对照组为53.54%(P<0.01,OR=2.32);高龄孕妇病例组患病率为67.17%,对照组为49.70%(P<0.01,OR=2.01),入选非条件对数优势回归多因素模型.结论:多次自然流产、社会心理因素、高龄孕妇等是复发性流产的主要危险因素.在复发性流产的预防策略中,应重视社会心理因素的作用.%Objective: To explore the risk factors of recurrent abortion, especially the value of the socio - psychological factors in recurrent abertion.Methods: 198 pregnant women with recurrent abortion were selected as case group, 165 pregnant women with threatened abortion during the same period were selected as control group, then a case - control study was conducted; unconditional logistic regression model was used for multifactor analysis of the research factors.Results: The significant level was 0.05, the incidences of natural abortion for many times in case group and control group were 90.00% and 49.70%, respectively, there was significant difference between the two groups ( P < 0.01, OR = 9.62); the proportions of socio - psychological factors in case group and control group were 87.37% and 53.54%,respectively, there was significant difference between the two groups ( P < 0.01, OR = 2.32 ); the proportions of pregnant women of advanced age in case group and control group were 67.17% and 49.70%, respectively, there was significant difference between the two groups (P < 0.01, OR = 2.01 ); the socio -psychological factors were included into unconditional logistic regression

  10. Determination of the solid consumption in the transport of sands in sea beds with gold 198; Determinacion del gasto solido en el transporte de arenas en lechos marinos con oro 198

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez A, G

    1983-07-01

    The study of the movement of sediments in sea beds, is necessary when one plans to build a port. Among the techniques used for this studies, it is the radiotracer balance that gives an useful estimation of the quantity of sediment that it moves per day and by meter (perpendicular to the displacement). The main objectives of this work are: to) to present the characteristics of the obtaining of the used radiotracer, describing details those used safety measures, b) to describe the handling of the radiotracer and it radiological safety, during the transport and injection in the sea bottom, c) description of the detection way and the used equipment, d) to describe the information processing obtained in the field and finally, e) the estimate of the solid consumption and the determination of the direction and speed of displacement of those sediments in the sea bottom, in front of the Tabasco coast, to be used jointly with the information obtained by means of other techniques so that one can make a good planning of the operations of dredging during the construction and later on the maintenance of the Dos Bocas marine terminal. The first step is to obtain the radiotracer that in this case was sand of uniform grain metric, marked superficially with Gold-198. The second step is to transport the sand to the place of interest, to place it in the injection equipment and to deposit it in the sea bottom. The third step is to detect the radiotracer in the sea bed, from a craft that drags a sled, which takes mounted a scintillation detector of sodium iodide activated with thallium NaI(Tl) (probe). The fourth step is to process the field information and to obtain the corresponding results. (Author)

  11. Bone fractures among postmenopausal patients with endocrine-responsive early breast cancer treated with 5 years of letrozole or tamoxifen in the BIG 1-98 trial

    DEFF Research Database (Denmark)

    Rabaglio, M; Sun, Z; Price, K N;

    2009-01-01

    BACKGROUND: To compare the incidence and timing of bone fractures in postmenopausal women treated with 5 years of adjuvant tamoxifen or letrozole for endocrine-responsive early breast cancer in the Breast International Group (BIG) 1-98 trial. METHODS: We evaluated 4895 patients allocated to 5 years...... of letrozole or tamoxifen in the BIG 1-98 trial who received at least some study medication (median follow-up 60.3 months). Bone fracture information (grade, cause, site) was collected every 6 months during trial treatment. RESULTS: The incidence of bone fractures was higher among patients treated...... with letrozole [228 of 2448 women (9.3%)] versus tamoxifen [160 of 2447 women (6.5%)]. The wrist was the most common site of fracture in both treatment groups. Statistically significant risk factors for bone fractures during treatment included age, smoking history, osteoporosis at baseline, previous...

  12. Prevention of central nervous system involvement with intrathecal 198Au colloid and methotrexate in non-Hodgkin lymphoma, acute non-lymphatic leukaemia and Ewing's sarcoma

    International Nuclear Information System (INIS)

    Intrathecal 198Au colloid and methotrexate were administered to 27 children (between 1972 and 1981) with non-lymphatic leukaemia, 21 with non-Hodgkin lymphoma and two with Ewing's sarcoma to prevent CNS involvement. In one boy with non-lymphatic leukaemia a stable remission after a three-year period of cytostatic treatment ended with isolated CNS involvement. No isolated CNS recurrence occurred in children with non-Hodgkin lymphoma receiving regular radiogold administration. Combined iris and CNS recurrence occurred in one child with non-Hodkin lymphoma. Eleven of 21 children with non-Hodgkin lymphoma have been in complete initial remission for 4-39 months without cytostatic treatment. Late cerebral complications have not been observed after 198Au colloid and methotrexate. (orig.)

  13. 46 CFR 177.315 - Vessels of not more than 19.8 meters (65 feet) in length carrying not more than 12 passengers.

    Science.gov (United States)

    2010-10-01

    ... carrying not more than 12 passengers. 177.315 Section 177.315 Shipping COAST GUARD, DEPARTMENT OF HOMELAND... Structure § 177.315 Vessels of not more than 19.8 meters (65 feet) in length carrying not more than 12... than 12 passengers that do not meet the standards in §§ 177.300 or 177.310 may be approved by...

  14. Results of a meningosis 'prophylaxis' with 198Au-colloid in acute leukemia and non-Hodgkin's disease - a long-term study

    International Nuclear Information System (INIS)

    The value of a meningosis 'prophylaxis' by means of 198Au-colloid was investigated in 64 children with acute leukemia and with non-Hodgkin's disease taking into account long-term remission results (28 - 79 months). Cytostatic therapy was terminated after 2.5 up to 3 years in 17 children, 11 of whom are alive with complete remission since 37 up to 62.5 months. Bone marrow relapses occurred in 4 children and initial meningosis neoplastica in 2 children. In 5 other children remission was terminated by an initial meningosis meoplastica while still under cytostatic therapy. Thus a total of 7 children (11%) suffered from initial meningosis neoplastica. Secondary meningosis neoplastica after bone marrow or gonad relapses occurred in 10 children (16%). Therefore, renewed meningosis 'prophylaxis' with 198Au-colloid has been performed successfully for several years. Sideeffects under intrathecal radiogold administration are markedly less than after telecobalt radiation or intrathecal injections of cytostatic drugs. Results of meningosis 'prophylaxis' by means of 198Au-colloid are comparable with the results of other established methods also with regard to long-term remission. (author)

  15. Interaction of Polymorphisms of Resistin Gene Promoter -420C/G, Glutathione Peroxidase -1 Gene Pro198Leu and Cigarette Smoking in Nonalcoholic Fatty Liver Disease

    Directory of Open Access Journals (Sweden)

    Chao-Xian Zhang

    2015-01-01

    Full Text Available Background: Many studies have suggested that cigarette smoking and polymorphisms of resistin and glutathione peroxidase-1 (GPx-1 genes are closely correlated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD. However, few reports have investigated these associations with respect to NAFLD susceptibility. We, therefore, examined the distribution of polymorphisms in GPx-1 and resistin genes in NAFLD patients and healthy controls and analyzed the relationship between these polymorphisms and smoking status. Methods: Nine hundred NAFLD patients and 900 healthy controls were selected, and the genetic polymorphisms of resistin gene promoter-420C/G and GPx-1 gene Pro198Leu were analyzed by polymorphism-polymerase chain reaction (PCR in DNA extracted from peripheral blood leukocytes. Interactions between the two mutants and the gene-environment interaction with cigarette smoking were also analyzed. Results: Genotype frequencies of −420C/G (GG and Pro198Leu (LL were significantly higher in NAFLD cases (49.56% and 50.11%, respectively compared with healthy controls (23.67% and 24.22%, respectively (P = 0.0069; P = 0.0072. Moreover, the risk of NAFLD with −420C/G (GG was significantly higher than in controls (odds ratio [OR] =3.1685, 95% confidence interval (CI =1.9366-5.2073. Individuals carrying Pro198Leu (LL had a high risk of NAFLD (OR = 3.1424, 95% CI = 1.7951-5.2367. Combined analysis of the polymorphisms showed that the −420C/G (GG/Pro198Leu (LL genotype was significantly more common in the NAFLD group than in the control group (39.44% vs. 12.78%, respectively, P = 0.0054, while individuals with −420C/G (GG/Pro198Leu (LL had a high risk of NAFLD (OR = 5.0357, 95% CI = 3.1852-7.8106. Moreover, the cigarette smoking rate in the NAFLD group was significantly higher than in the control group (OR = 1.8990, P = 0.0083 in the smoking index (SI ≤400 subgroup; OR = 5.0937, P = 0.0051 in the SI >400 subgroup, and statistical analysis

  16. Systematic decay studies of even-even 132-138Nd, 144-158Gd, 176-196Hg and 192-198Pb isotopes

    International Nuclear Information System (INIS)

    The alpha and cluster decay properties of the 132-138Nd, 144-158Gd, 176-196Hg and 192-198Pb even-even isotopes in the two mass regions A=130-158 and A=180-198 are analyzed using the Coulomb and Proximity Potential Model. On examining the clusters at corresponding points in the cold valleys (points with same A2) of the various isotopes of a particular nucleus we find that at certain mass numbers of the parent nuclei, the clusters emitted are getting shifted to the next lower atomic number. It is interesting to see that the change in clusters appears at those isotopes where a change in shape is occurring correspondingly. Such a change of clusters with shape change is studied for the first time in cluster decay. The alpha decay half lives of these nuclei are computed and these are compared with the available experimental alpha decay data. It is seen that the two are in good agreement. On making a comparison of the alpha half lives of the normal deformed and superdeformed nuclei, it can be seen that the normal deformed 132Nd, 176-188Hg and 192Pb nuclei are found to be better alpha emitters than the superdeformed (in excited state) 134,136Nd, 190-196Hg and 194Pb nuclei. The cluster decay studies reveal that as the atomic number of the parent nuclei increases the N≠Z cluster emissions become equally or more probable than the N=Z emissions. On the whole the alpha and cluster emissions are more probable from the parents in the heavier mass region (A=180-198) than from the parents in the lighter mass region (A=130-158). The effect of quadrupole (β2) and hexadecapole (β4) deformations of parent and fragments on half life times are also studied.

  17. Negative Effects of a Nonhost Proteinase Inhibitor of ~19.8 kDa from Madhuca indica Seeds on Developmental Physiology of Helicoverpa armigera (Hübner)

    OpenAIRE

    Farrukh Jamal; Dushyant Singh; Pandey, Prabhash K.

    2014-01-01

    An affinity purified trypsin inhibitor from the seed flour extracts of Madhuca indica (MiTI) on denaturing polyacrylamide gel electrophoresis showed that MiTI consisted of a single polypeptide chain with molecular mass of ~19.8 kDa. MiTI inhibited the total proteolytic and trypsin-like activities of the midgut proteinases of Helicoverpa armigera larvae by 87.51% and 76.12%, respectively, at concentration of 5 µg/mL with an IC50 of 1.75 µg/mL against trypsin like midgut proteinases. The enzyme...

  18. Effect of concrete buildings on the environmental neutron flux by using the reaction 197Au (n,γ) 198Au and extremely low level gamma ray spectroscopy

    Institute of Scientific and Technical Information of China (English)

    K. KOMURA; N.K. AHMED; A.H. EL-KAMEL; A.M.M. YOUSEF

    2004-01-01

    The activation of gold by environmental neutrons through the reaction 197Au (n,γ) 198Au was used to study the effect of concrete buildings on the neutron flux, and to estimate the thermal neutron flux inside and outside these buildings. The results showed that three ceilings of thickness 34 g/cm2 decrease the fast neutrons to 26% from its original value. However, the same reinforced concrete decreases the slow neturon flux to only 62% of its original value. The thermal neutron flux at 283 m from the center of Training Reactor of Kinki University, was twice higher than the environmental neutron background.

  19. Streamlined approach for environmental restoration workplan for Corrective Action Unit 198: Test Cell C filter tank closure, Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    This plan addresses characterization and closure of Corrective Action Unit (CAU) 198 identified in the Federal Facility Agreement and Consent Order. The site is located at the Nevada Test Site (NTS) Area 25 Test Cell C Complex. The CAU consists of one Corrective Action Site (CAS) 25-23-12 which includes two aboveground radioactive wastewater filter tanks. The tanks have an estimated capacity of 2,271 liters (600 gallons) each and were used to filter radioactive wastewater originating from the Test Cell C ''Nuclear Furnace 1'' testing. The tanks contain radioisotopes. Process knowledge indicates that the most likely isotopes of concern include 90Strontium and 137Cesium

  20. Adsorption of Reactive Red 198 Azo Dye fromAqueous Solution onto theWaste Coagulation Sludge of theWater Treatment Plants

    OpenAIRE

    Mahmoudi, M; G.R Moussavi; H. Asilian

    2010-01-01

    "n "n "nBackgrounds and Objectives:Much attention has been recently paid on using waste materials as adsorbents for removal of contaminants from water and wastewater. A new low cost waste was examined for its capacity to adsorb RR198, an azo reactive model dye, from an aqueous solution."nMaterials andMethods: The waste was dried, powdered and characterized before being used as an adsorbent. The effects of pH (3-10), adsorbent dose (0.2-3 g), dye concentration and contact time on the adsorptio...

  1. Closed shell effects from the stability and instability of deformed and superdeformed nuclei against cluster decays in the mass regions 130-158 and 180-198

    OpenAIRE

    Gupta, Raj K; Dhaulta, Sharda; Kumar, Rajesh; Balasubramaniam, M.; Münzenberg, G.; Scheid, Werner

    2003-01-01

    The stability and/or instability of the deformed and superdeformed nuclei, $^{133-137}_{60}$Nd, $^{144-158}_{64}$Gd, $^{176-194}_{80}$Hg, and $^{192-198}_{82}$Pb parents, coming from three regions of different superdeformations, are studied with respect to the $\\alpha$ and heavy cluster decays. The $\\alpha$-decay studies also include the heavier $^{199-210}$Pb nuclei, for reasons of spherical magic shells at Z=82 and N=126. The calculations are made by using the preformed cluster-decay model,...

  2. Evidence for {open_quotes}magnetic rotation{close_quotes} in nuclei: New results on the M1-bands of {sup 198,199}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Clark, R.M. [Lawrence Berkeley National Lab., CA (United States)

    1996-12-31

    Lifetimes of states in four of the M1-bands in {sup 198,199}Pb have been determined through a Doppler Shift Attenuation Method measurement performed using the Gammasphere array. The deduced B(M1) values, which are a sensitive probe of the underlying mechanism for generating these sequences, show remarkable agreement with Tilted Axis Cranking (TAC) calculations. Evidence is also presented for the possible termination of the bands. The results represent clear evidence for a new concept in nuclear excitations: {open_quote}magnetic rotation{close_quote}.

  3. An aqueous route to [Ta6O19]8- and solid-state studies of isostructural niobium and tantalum oxide complexes.

    Energy Technology Data Exchange (ETDEWEB)

    Nyman, May D.; Anderson, Travis Mark [Sandia National Laboratories, Albuquerque, NM; Alam, Todd M. [Sandia National Laboratories, Albuquerque, NM; Rodriguez, Mark Andrew [Sandia National Laboratories, Albuquerque, NM; Joel N. Bixler; Francois Bonhomme

    2007-10-01

    Tantalate materials play a vital role in our high technology society: tantalum capacitors are found in virtually every cell phone. Furthermore, electronic characteristics and the incredibly inert nature of tantalates renders them ideal for applications such as biomedical implants, nuclear waste forms, ferroelectrics, piezoelectrics, photocatalysts and optical coatings. The inert and insoluble nature of tantalates is not fundamentally understood; and furthermore poor solubility renders fabrication of novel or optimized tantalates very difficult. We have developed a soft chemical route to water-soluble tantalum oxide clusters that can serve as both precursors for novel tantalate materials and ideal models for experimental and computational approaches to understanding the unusually inert behavior of tantalates. The water soluble cluster, [Ta6O19]8- is small, highly symmetric, and contains the representative oxygen types of a metal oxide surface, and thus ideally mimics a complex tantalate surface in a simplistic form that can be studied unambiguously. Furthermore; in aqueous solution, these highly charged and super-basic clusters orchestrate surprising acid-base behavior that most likely plays an important role in the inertness of related oxide surfaces. Our unique synthetic approach to the [Ta6O19]8- cluster allowed for unprecedented enrichment with isotopic labels (17O), enabling detailed kinetic and mechanistic studies of the behavior of cluster oxygens, as well as their acid-base behavior. This SAND report is a collection of two publications that resulted from these efforts.

  4. Gold nanoparticles production using reactor and cyclotron based methods in assessment of (196,198)Au production yields by (197)Au neutron absorption for therapeutic purposes.

    Science.gov (United States)

    Khorshidi, Abdollah

    2016-11-01

    Medical nano-gold radioisotopes is produced regularly using high-flux nuclear reactors, and an accelerator-driven neutron activator can turn out higher yield of (197)Au(n,γ)(196,198)Au reactions. Here, nano-gold production via radiative/neutron capture was investigated using irradiated Tehran Research Reactor flux and also simulated proton beam of Karaj cyclotron in Iran. (197)Au nano-solution, including 20nm shaped spherical gold and water, was irradiated under Tehran reactor flux at 2.5E+13n/cm(2)/s for (196,198)Au activity and production yield estimations. Meanwhile, the yield was examined using 30MeV proton beam of Karaj cyclotron via simulated new neutron activator containing beryllium target, bismuth moderator around the target, and also PbF2 reflector enclosed the moderator region. Transmutation in (197)Au nano-solution samples were explored at 15 and 25cm distances from the target. The neutron flux behavior inside the water and bismuth moderators was investigated for nano-gold particles transmutation. The transport of fast neutrons inside bismuth material as heavy nuclei with a lesser lethargy can be contributed in enhanced nano-gold transmutation with long duration time than the water moderator in reactor-based method. Cyclotron-driven production of βeta-emitting radioisotopes for brachytherapy applications can complete the nano-gold production technology as a safer approach as compared to the reactor-based method. PMID:27524041

  5. Results of long-term studies on intra-articular radiosynoviorthesis using yttrium-90 colloids and gold-198 colloids in chronic synovitis

    International Nuclear Information System (INIS)

    The therapeutic effects of radiosynoviorthesis using yttrium-90 or gold-198 were investigated in a total of 151 patients showing various forms of rheumatoid disorders, among which rheumatoid arthritis prevailed. The duration of the observation periods varied from 4 to 44 months. 187 knee joints and 28 wrist joints were examined prior and subsequent to radiosynoviorthesis, in each case separately for pain, inflammatory signs and functional performance, and the individual therapeutic effects achieved were evaluated. Radiosynoviorthesis was found to be particularly beneficial in painful and inflammatory conditions. As far as these two parameters, pain and inflammation, were concerned, no marked differences in therapeutic potency were discernible between Y-90 and Au-198. The most favourable results of radiosynoviorthesis were observed after periods ranging from 6 to 30 months. It is of particular note that the effects of radiosynoviorthesis were seen to be significantly better in patients with rheumatoid serum factors as compared to individuals without those serum factors. Account is further taken of special fields of application and contra-indications or possible side-effects of radiosynoviorthesis. (TRV)

  6. Description of E4 Transitions in A = 192, 194,196, 198 Platinum Isotopes in a Microscopic sdgIBM- 1

    Institute of Scientific and Technical Information of China (English)

    ZHANG ZhanJun; YANG Jie; WANG Xin; LIU Yong

    2001-01-01

    Influence of the effective fermion hexadecapole force newly incorporated in a microscopic sdgIBM-1 on spectra, reduced E2 and E4 transition matrix elements (T(E2)s and T(E4)s) in the even-even platinum isotopes (A = 192,194,196,198) is investigated in terms of numerical calculations. It is found that the introduced interaction causes only limited modification to the spectrum and T(E2)s, apart from a few exceptions. However, it plays an essential role in describing E4 transitions. Thus in the case that the interaction is incorporated with certain strength, a reasonable description of all the E4 transitions in the platinum isotopes is reached in the microscopic sdgIBM-1 in comparing both to experimental data and the results calculated in phenomenological boson model.``

  7. High strain in polycrystalline Ni48.8Mn31.4Ga19.8 Heusler alloys under overlapped static and oscillating magnetic fields

    International Nuclear Information System (INIS)

    Martensitic polycrystalline Ni48.8Mn31.4Ga19.8 Heusler alloys, with a stacking period of 14 atomic planes at room temperature, were innovatively processed by combining high-energy ball milling and powder metallurgy. Bulk samples were mechanically coupled to a piezoelectric material in a parallel configuration, and the mechanical deformation of the studied system due to the twin's variant motion was investigated under overlapped static and oscillating magnetic fields. A reversible and high mechanical deformation is observed when the frequency of the oscillating magnetic field is tuned with the natural vibration frequency of this system. In this condition, a linear deformation as a function of the static magnetic field amplitude occurs in the ±4 kOe range, and a mechanical deformation of 2% at 10 kOe is observed.

  8. A Compact $^{3}H(p,\\gamma)^{1}He$ 19.8-MeV Gamma-Ray Source for Energy Calibration at the Sudbury Neutrino Observatory

    CERN Document Server

    Poon, A W P; Waltham, C E; Browne, M C; Roberston, R G H; Kherani, N P; Mak, H B

    2000-01-01

    The Sudbury Neutrino Observatory (SNO) is a new 1000-tonne D2O Cerenkov solar neutrino detector. A high energy gamma-ray source is needed to calibrate SNO beyond the 8B solar neutrino endpoint of 15 MeV. This paper describes the design and construction of a source that generates 19.8-MeV gamma rays using the 3H(p,gamma)4He reaction (``pt''), and demonstrates that the source meets all the physical, operational and lifetime requirements for calibrating SNO. An ion source was built into this unit to generate and to accelerate protons up to 30 keV, and a high purity scandium tritide target with a scandium-tritium atomic ratio of 1:2.0+/-0.2 was included. This pt source is the first self-contained, compact, and portable high energy gamma-ray source (E>10 MeV).

  9. Use of Radioactive Gold, 198AU, to Study the Radius of Action of Colonies of Bumble-Bees (Bombus Sp.) with a View to Pollination of Cultivated Plants

    International Nuclear Information System (INIS)

    It is generally very easy to label a colony with a radioisotope, taking advantage of the constant exchange of food between individuals. Bumble-bees, although living in a colony, do not engage in direct exchange, but it has been shown that continual transfer takes place through the honey cells (secondary trophallaxia). In these conditions a bumble-bee colony can be labelled as easily as a hive of bees. Gold-198 was successfully used for the tests, which enabled us to obtain important and unpublished information on the behaviour of workers in bumble-bee colonies situated close to fields of leguminous crops, with a view to enhancing grain production. Questions that have been investigated by this method include the time required to become familiarized to a new site, fixation on a particular species of plant, the radius of action and the determinate character of the flight paths and the honey-gathering sectors. (author)

  10. Adsorption of Reactive Red 198 Azo Dye fromAqueous Solution onto theWaste Coagulation Sludge of theWater Treatment Plants

    Directory of Open Access Journals (Sweden)

    M. Mahmoudi

    2010-04-01

    Full Text Available "n "n "nBackgrounds and Objectives:Much attention has been recently paid on using waste materials as adsorbents for removal of contaminants from water and wastewater. A new low cost waste was examined for its capacity to adsorb RR198, an azo reactive model dye, from an aqueous solution."nMaterials andMethods: The waste was dried, powdered and characterized before being used as an adsorbent. The effects of pH (3-10, adsorbent dose (0.2-3 g, dye concentration and contact time on the adsorption efficiency were investigated. Equilibrium study data were modeled using Langmuir and Freundlich models."nResults: The characterization analysis indicated that itwas composedmainly of ferric hydroxide. The powder had a BET and average pore size of 107 m2/g and 4.5 nm, respectively. The results showed that dye removal was highest at a solution pH of 7 to 8 and a powder dose of 2 g/L. The RR198 removal percentage decreased from 100& to 43& at 140 min contact time when the concentration of dye was increased from 25 mg/L to 100 mg/L, at optimum pH and dosage. The Langmuir equation provided the best fit for the experimental data. The maximum adsorption capacity was calculated to be 34.4 mg/g."nConclusion: According to the obtained results, the water coagulation waste sludge appears to be a suitable low cost and effcient adsorbent for removing reactive azo dyes from waste streams.

  11. Astatination of closo-dodecaborate(2-) anion

    Czech Academy of Sciences Publication Activity Database

    Orlova, A.; Lebeda, Ondřej; Tolmachev, V.; Lundquist, H.; Carlsson, J.; Sjöberg, S.

    Cambridge : The Royal Society of Chemistry , 2000 - (Davidson, M.; Hughes, A.; Marder, T.; Wade , K.), s. 144-147 [Conference "Contemporary Boron Chemistry ". Durham (GB), 11.07.1999-15.07.1999] Institutional research plan: CEZ:AV0Z1048901 Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  12. Intestinal-type of differentiation predicts favourable overall survival: confirmatory clinicopathological analysis of 198 periampullary adenocarcinomas of pancreatic, biliary, ampullary and duodenal origin

    International Nuclear Information System (INIS)

    Periampullary adenocarcinomas comprise pancreatic, distal bile duct, ampullary and duodenal adenocarcinoma. The epithelia of these anatomical structures share a common embryologic origin from the foregut. With steadily increasing numbers of pancreatoduodenectomies over the last decades, pathologists, surgeons and oncologists are more often confronted with the diagnosis of “other than pancreatic” periampullary cancers. The intestinal subtype of ampullary cancer has been shown to correlate with better prognosis. Histological subtype and immunohistochemical staining pattern for CK7, CK20 and CDX2 were assessed for n = 198 cases of pancreatic ductal, distal bile duct, ampullary and duodenal adenocarcinoma with clinical follow-up. Routine pathological parameters were included in survival analysis performed with SPSS 20. In univariate analysis, intestinal subtype was associated with better survival in ampullary, pancreatic ductal and duodenal adenocarcinoma. The intestinal type of pancreatic ductal adenocarcinoma was not associated with intraductal papillary mucinous neoplasm and could not be reliably diagnosed by immunohistochemical staining pattern alone. Intestinal differentiation and lymph node ratio, but not tumor location were independent predictors of survival when all significant predictor variables from univariate analysis (grade, TNM stage, presence of precursor lesions, surgical margin status, perineural, vascular and lymphatic vessel invasion, CK7 and CDX2 staining pattern) were included in a Cox proportional hazards model. Intestinal type differentiation and lymph node ratio but not tumor location are independent prognostic factors in pooled analysis of periampullary adenocarcinomas. We conclude that differentiation is more important than tumor location for prognostic stratification in periampullary adenocarcinomas

  13. PEG Coating Reduces NMR Relaxivity of Mn0.5Zn0.5Gd0.02Fe1.98O4 Hyperthermia Nanoparticles

    Science.gov (United States)

    Issa, Bashar; Qadri, Shahnaz; Obaidat, Ihab M.; Bowtell, Richard W.; Haik, Yousef

    2011-01-01

    Purpose To investigate both T1 and T2 MR relaxation enhancement of Gd substituted Zn-Mn ferrite magnetic nanoparticles. Both uncoated and polyethylene glycol (PEG) coated particles were used. Materials and Methods Chemical co-precipitation was used to synthesize particles in the form Mn0.5Zn0.5Gd0.02Fe1.98O4 suitable for hyperthermia applications. Physical characterization of the magnetic nanoparticles included SEM, TEM, ICP, and SQUID. T1 and T2 measurements were performed at 1.5 T. Results The saturation magnetization was 12.86 emu/g while the particle’s magnetic moment was 1.86 × 10−19 J/T. The particle size increased due to coating, while 1/T1 and 1/T2 relaxivities (26 °C) decreased from 2.5 to 0.7 and from 201.3 to 76.6 s−1 mM−1, respectively at a magnetic field 1.5 T. Conclusion The reduction in both 1/T1 and 1/T2 is attributed to increased distance of closest approach between the protons and the magnetic core caused by the shielding provided by the high molecular weight PEG. 1/T2 data is compared to existing theoretical models using a modified radius that takes into account both possible agglomeration of the particles and increased inter-particle separation induced by PEG coating. PMID:21928382

  14. Negative effects of a nonhost proteinase inhibitor of ~19.8 kDa from Madhuca indica seeds on developmental physiology of Helicoverpa armigera (Hübner).

    Science.gov (United States)

    Jamal, Farrukh; Singh, Dushyant; Pandey, Prabhash K

    2014-01-01

    An affinity purified trypsin inhibitor from the seed flour extracts of Madhuca indica (MiTI) on denaturing polyacrylamide gel electrophoresis showed that MiTI consisted of a single polypeptide chain with molecular mass of ~19.8 kDa. MiTI inhibited the total proteolytic and trypsin-like activities of the midgut proteinases of Helicoverpa armigera larvae by 87.51% and 76.12%, respectively, at concentration of 5 µg/mL with an IC50 of 1.75 µg/mL against trypsin like midgut proteinases. The enzyme kinetic studies demonstrated that MiTI is a competitive inhibitor with a K i value of 4.1 × 10(-10) M for Helicoverpa trypsin like midgut proteinases. In vivo experiments with different concentrations of MiTI in artificial diet (0.5, 1.0, and 1.5% w/w) showed an effective downfall in the larval body weight and an increase in larval mortality. The concentration of MiTI in the artificial diet to cause 50% mortality (LD50) of larvae was 1.5% w/w and that to cause reduction in mass of larvae by 50% (ED50) was 1.0% w/w. Nutritional indices observations suggest the toxic and adverse effects of MiTI on the growth and development of H. armigera larvae. The results suggest a strong bioinsecticidal potential of affinity purified MiTI which can be exploited in insect pest management of crop plants. PMID:25298962

  15. Negative Effects of a Nonhost Proteinase Inhibitor of ~19.8 kDa from Madhuca indica Seeds on Developmental Physiology of Helicoverpa armigera (Hübner

    Directory of Open Access Journals (Sweden)

    Farrukh Jamal

    2014-01-01

    Full Text Available An affinity purified trypsin inhibitor from the seed flour extracts of Madhuca indica (MiTI on denaturing polyacrylamide gel electrophoresis showed that MiTI consisted of a single polypeptide chain with molecular mass of ~19.8 kDa. MiTI inhibited the total proteolytic and trypsin-like activities of the midgut proteinases of Helicoverpa armigera larvae by 87.51% and 76.12%, respectively, at concentration of 5 µg/mL with an IC50 of 1.75 µg/mL against trypsin like midgut proteinases. The enzyme kinetic studies demonstrated that MiTI is a competitive inhibitor with a Ki value of 4.1×10−10 M for Helicoverpa trypsin like midgut proteinases. In vivo experiments with different concentrations of MiTI in artificial diet (0.5, 1.0, and 1.5% w/w showed an effective downfall in the larval body weight and an increase in larval mortality. The concentration of MiTI in the artificial diet to cause 50% mortality (LD50 of larvae was 1.5% w/w and that to cause reduction in mass of larvae by 50% (ED50 was 1.0% w/w. Nutritional indices observations suggest the toxic and adverse effects of MiTI on the growth and development of H. armigera larvae. The results suggest a strong bioinsecticidal potential of affinity purified MiTI which can be exploited in insect pest management of crop plants.

  16. Streamlined Approach for Environmental Restoration Closure Report for Corrective Action Unit 198: Test Cell C Filter Tank Closure Nevada Test Site, Nevada

    International Nuclear Information System (INIS)

    This closure report (CR) provides documentation for the closure of Corrective Action Unit (CAU) 198 identified in the Federal Facility Agreement and Consent Order (FFACO). The site is located at the Nevada Test Site (NTS) Area 25 Test Cell C Complex (Figure 1). The CAU consists of one Corrective Action Site (CAS) 25-23-12 which includes two aboveground radioactive wastewater filter tanks used during the Nuclear Furnace Testing at Test Cell C. The Test Cell C complex was one of several facilities dedicated to the development of nuclear rocket technology. Test Cell C was designed to test nuclear rocket reactors. Part of the testing program included Nuclear Furnace Tests. The Nuclear Furnace was a water-moderated, hydrogen-cooled, 44-megawatt reactor used to test fuel elements for the nuclear rocket engine. The Nuclear Furnace in itself was not a nuclear rocket engine. During testing, hydrogen exited the reactor at a temperature of 2,440 degrees Kelvin. Water was injected into the gas stream to cool the hydrogen and capture the various radiological isotopes. Hydrogen gas effluent was decontaminated through a multistage process before being burned at the Test Cell C flare stack. A by-product of the decontamination process produced water contaminated with mixed fission products. Prior to discharge to a tile drain system (CAU 267) the water was filtered through the two 2271-liters (600-gallon) filter tanks (Department of Energy [DOE], 1998). Reactor development, engine testing, and rocket development activities were ended in the early 1970s. The filter tanks have remained inactive since that time. The site is currently roped off and posted with ''Caution Radiation Area'' signs. The filter tanks were located on the east side of Test Cell C, approximately 15.2 meters (50 feet) from the facility fence line (Figure 2)

  17. Validation of absolute axial neutron flux distribution calculations with MCNP with 197Au(n,γ)198Au reaction rate distribution measurements at the JSI TRIGA Mark II reactor.

    Science.gov (United States)

    Radulović, Vladimir; Štancar, Žiga; Snoj, Luka; Trkov, Andrej

    2014-02-01

    The calculation of axial neutron flux distributions with the MCNP code at the JSI TRIGA Mark II reactor has been validated with experimental measurements of the (197)Au(n,γ)(198)Au reaction rate. The calculated absolute reaction rate values, scaled according to the reactor power and corrected for the flux redistribution effect, are in good agreement with the experimental results. The effect of different cross-section libraries on the calculations has been investigated and shown to be minor. PMID:24316530

  18. Study and construction of a {beta}-spectrometer of uniform axial magnetic field fitted with a {beta}-{gamma} coincidence selector. Study of the {beta} spectra of {sup 32}P, {sup 203}Hg, {sup 198}Au. Measurement of the conversion coefficients of {sup 203}Ti and of {sup 198}Hg; Etude et realisation d'un spectrometre-{beta} a champ magnetique axial uniforme, muni d'un selecteur de coincidence {beta}-{gamma}. Etude des spectres {beta} du {sup 32}p, {sup 203}Hg, {sup 198}Au. Mesure des coefficients de conversion du {sup 203}Ti et du {sup 198}Hg

    Energy Technology Data Exchange (ETDEWEB)

    Parsignault, D. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-06-01

    In the first part is given the principle of the beta spectrometer with uniform axial field using systematically the idea of caustics. The apparatus is described and its properties compared to those deduced from trajectory calculations. The {beta}-ray and {gamma}-ray detectors and the device for selecting coincidences with a 2 {tau} resolution of 5 nanoseconds are also presented. In the second part, the spectrometer is used for studying reference elements and the most accurate results are confirmed. The {beta} spectrum of {sup 60}Co has a statistical form with an accuracy of 1 per cent; the maximum energy E{sub 0} is 316.5 {+-} 1.5 keV. That of the 7/2 + {yields} 11/2 transition for {sup 137}Cs has a unique form, once forbidden. E{sub 0}= 522 {+-} 3 keV. Conversion coefficients {alpha}{sub k} = 96 {+-} 1 X 10{sup -3} {alpha}L + M + N = 20.9 {+-} 0.5 X 10{sup -3}. The two {beta} spectra of {sup 59}Fe, separated by coincidence with the gamma, have the statistical form E{sub 0} = 462 {+-} 2 keV (55.1 + 0,3 per cent) and E{sub 1} = 275 {+-} 4 keV (44.9 {+-} 0.3 per cent). It is then verified whether the l selection rule is apparent in the shape of the phosphorus 32 beta spectrum. It is found in fact that it is not of statistical shape and its shape coefficient is determined. For a theoretical interpretation it is necessary to have better approximations than those generally used and this interpretation will not be unique. This work has also made it possible to show that the source contains a small proportion of {sup 33}P. The study of the {sup 203}Hg {beta} spectrum followed by the 279 keV gamma spectrum is designed to determine the conversion coefficients. The interior spectrum of gold 198 is not of statistical shape either. The form coefficient is determined together with the conversion coefficients which are in slight disagreement with those calculated by Rose or Sliv. An interpretation of the spectrum is put forward which proposes an imperfect compensation for the

  19. Sr{sub 1.98}Eu{sub 0.02}SiO{sub 4} luminescence whisker based on vapor-phase deposition: Facile synthesis, uniform morphology and enhanced luminescence properties

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Jian, E-mail: xujian@stu.xmu.edu.cn [Department of Materials Science and Engineering, Xiamen University, Xiamen 361005 (China); Hassan, Dhia A. [Department of Materials Science and Engineering, Xiamen University, Xiamen 361005 (China); Department of Chemistry, College of Education for Pure Science, University of Basrah, 61004 (Iraq); Zeng, Renjie; Peng, Dongliang [Department of Materials Science and Engineering, Xiamen University, Xiamen 361005 (China); Fujian Key Lab of Advanced Special Material, Xiamen University, Xiamen 361005 (China); Key Laboratory of High Performance Ceramic Fibers, Ministry of Education, Xiamen 361005 (China)

    2015-11-15

    Highlights: • For the first time, it is possible to obtain Sr{sub 1.98}Eu{sub 0.02}SiO{sub 4} whisker. • The whiskers are smooth and uniform with L/D ratio over 50. • Durability and thermal stability of the whisker are enhanced. - Abstract: A high performance strontium silicate phosphor has been successfully synthesized though a facile vapor-phase deposition method. The product consists of single crystal whiskers which are smooth and uniform, and with a sectional equivalent diameter of around 5 μm; the aspect ratio is over 50 and no agglomeration can be observed. X-ray diffraction result confirmed that the crystal structure of the whisker was α’-Sr{sub 2}SiO{sub 4}. The exact chemical composition was Sr{sub 1.98}Eu{sub 0.02}SiO{sub 4} which was analyzed by energy dispersive spectrometer and inductively coupled plasma-mass spectrometer. The whisker shows broad green emission with peak at 523 nm ranging from 470 to 600 nm (excited at 370 nm). Compared with traditional Sr{sub 2}SiO{sub 4}:Eu phosphor, durability (at 85% humidity and 85 °C) and thermal stability of the whisker are obviously improved. Moreover, growth mechanism of the Sr{sub 1.98}Eu{sub 0.02}SiO{sub 4} whiskers is Vapor–Liquid–Solid. On a macro-scale, the product is still powder which makes it suitable for the current packaging process of WLEDs.

  20. 198例心脏机械瓣膜置换术患者口服华法林的临床监测及护理%Clinical monitoring and nursing on 198 patients administered oral warfarin after cardiac valve replacement

    Institute of Scientific and Technical Information of China (English)

    侯文权; 侯文锋; 周凌云; 徐胜

    2010-01-01

    目的 研究心脏机械瓣膜置换术后口服华法林患者血浆凝血酶原前体蛋白(prothrombin precursor protein,PIVKA-Ⅱ)、凝血酶原时间(prothrombin time,PT)、国际标准化比率( international normalized rate,INR)的变化及其临床意义.方法 198例心脏机械瓣膜置换术后口服华法林患者为病例组,30例门诊体检人员为健康对照组,分别进行血浆PIVKA-Ⅱ、PT、INR测定.结果 研究组首次服华法林后8 h后,血浆PIVKA-Ⅱ浓度即显著增高,差异有统计学意义(P<0.05);首次服华法林24 h后,PT、 INR显著增高,差异有统计学意义(P<0.05).抗凝后多数患者有不同程度的出血,其中2 例出现腰大肌血肿,3 例出现脑出血,1 例出现脑血栓,经手术治疗、药物调整及护理后均康复.结论 上述指标能较客观地反映心脏机械瓣膜置换术后口服华法林患者的病理变化过程.对患者进行心理治疗等护理可以提高治疗效果、减少并发症.

  1. Standardization and application of the tetraprimer ARMS-PCR technique for screening of the E198A SNP in the β-tubulin gene of hookworm populations in Brazil.

    Science.gov (United States)

    Furtado, Luis Fernando Viana; Alves, William Pereira; Moreira, Thayse Batista; Costa Junior, Livio Martins; Miranda, Rodrigo Rodrigues Cambraia; Rabelo, Élida Mara Leite

    2016-07-15

    The tetraprimer ARMS-PCR technique is efficient for SNP detection and can be used to search for polymorphisms associated with drug resistance. However, the establishment of this methodology is not always straightforward because of the constraints on primer design due to the restrictions of the polymorphic regions. Here, we describe the standardization of the tetraprimer ARMS-PCR methodology for the detection of a SNP at codon 198 of the Ancylostoma caninum β-tubulin gene. This SNP is associated with resistance to albendazole in various nematodes. The methodology was used to screen 327 individuals from 6 different locations. No mutation was found in any of the samples. This methodology will be useful for screening for the E198A SNP in the β-tubulin gene of canine hookworms in a broader population to determine whether this SNP is associated with benzimidazole resistance in this species. The method could also be adapted for the analysis of other SNPs in other nematode species. PMID:27270392

  2. Basic residues in the 74-83 and 191-198 segments of protein kinase CK2 catalytic subunit are implicated in negative but not in positive regulation by the beta-subunit

    DEFF Research Database (Denmark)

    Sarno, S; Vaglio, P; Marin, O; Meggio, F; Issinger, O G; Pinna, L A

    1997-01-01

    Protein kinase CK2 is a ubiquitous pleiotropic serine/threonine protein kinase whose holoenzyme is comprised of two catalytic (alpha and/or alpha') and two non-catalytic, beta-subunits. The beta-subunit possesses antagonist functions that can be physically dissected by generating synthetic...... fragments encompassing its N-terminal and C-terminal domains. Here we show that by mutating basic residues in the 74-77 and in the 191-198 regions of the alpha-subunit, the negative regulation by the beta-subunit and by its N-terminal synthetic fragment CK2beta-(1-77), which is observable using calmodulin...... as a substrate for phosphorylation, is drastically reduced. In contrast, the positive regulation by a C-terminal, CK2beta-(155-215)-peptide is unaffected or even increased. Moreover, the basal activity of alpha mutants K74-77A, K79R80K83A, and R191R195K198A toward specific peptide substrates is...

  3. Study and construction of a β-spectrometer of uniform axial magnetic field fitted with a β-γ coincidence selector. Study of the β spectra of 32P, 203Hg, 198Au. Measurement of the conversion coefficients of 203Ti and of 198Hg

    International Nuclear Information System (INIS)

    In the first part is given the principle of the beta spectrometer with uniform axial field using systematically the idea of caustics. The apparatus is described and its properties compared to those deduced from trajectory calculations. The β-ray and γ-ray detectors and the device for selecting coincidences with a 2 τ resolution of 5 nanoseconds are also presented. In the second part, the spectrometer is used for studying reference elements and the most accurate results are confirmed. The β spectrum of 60Co has a statistical form with an accuracy of 1 per cent; the maximum energy E0 is 316.5 ± 1.5 keV. That of the 7/2 + → 11/2 transition for 137Cs has a unique form, once forbidden. E0= 522 ± 3 keV. Conversion coefficients αk = 96 ± 1 X 10-3 αL + M + N = 20.9 ± 0.5 X 10-3. The two β spectra of 59Fe, separated by coincidence with the gamma, have the statistical form E0 = 462 ± 2 keV (55.1 + 0,3 per cent) and E1 = 275 ± 4 keV (44.9 ± 0.3 per cent). It is then verified whether the l selection rule is apparent in the shape of the phosphorus 32 beta spectrum. It is found in fact that it is not of statistical shape and its shape coefficient is determined. For a theoretical interpretation it is necessary to have better approximations than those generally used and this interpretation will not be unique. This work has also made it possible to show that the source contains a small proportion of 33P. The study of the 203Hg β spectrum followed by the 279 keV gamma spectrum is designed to determine the conversion coefficients. The interior spectrum of gold 198 is not of statistical shape either. The form coefficient is determined together with the conversion coefficients which are in slight disagreement with those calculated by Rose or Sliv. An interpretation of the spectrum is put forward which proposes an imperfect compensation for the various elements of the matrix. (author)

  4. High strain in polycrystalline Ni{sub 48.8}Mn{sub 31.4}Ga{sub 19.8} Heusler alloys under overlapped static and oscillating magnetic fields

    Energy Technology Data Exchange (ETDEWEB)

    Montanher, D. Z.; Pereira, J. R. D.; Cótica, L. F.; Santos, I. A. [Department of Physics, State University of Maringá, Av. Colombo 5790, Maringá - PR 87020-900 (Brazil); Gotardo, R. A. M. [Technological Federal University of Paraná, Av. Alberto Carazzai 1640, Cornélio Procópio - PR 86300-000 (Brazil); Viana, D. S. F.; Garcia, D.; Eiras, J. A. [Department of Physics, Federal University of São Carlos, Rod. Washington Luiz, Km 235, São Carlos - SP 13565-905 (Brazil)

    2014-09-21

    Martensitic polycrystalline Ni{sub 48.8}Mn{sub 31.4}Ga{sub 19.8} Heusler alloys, with a stacking period of 14 atomic planes at room temperature, were innovatively processed by combining high-energy ball milling and powder metallurgy. Bulk samples were mechanically coupled to a piezoelectric material in a parallel configuration, and the mechanical deformation of the studied system due to the twin's variant motion was investigated under overlapped static and oscillating magnetic fields. A reversible and high mechanical deformation is observed when the frequency of the oscillating magnetic field is tuned with the natural vibration frequency of this system. In this condition, a linear deformation as a function of the static magnetic field amplitude occurs in the ±4 kOe range, and a mechanical deformation of 2% at 10 kOe is observed.

  5. Thermal neutron calibration of a tritium extraction facility using the 6Li(n,t)4He/197Au(n,γ)198Au cross section ratio for standardization

    International Nuclear Information System (INIS)

    Absolute tritium activities in a neutron-activated metallic lithium samples have been measured by liquid scintillation methods to provide data needed for the determination of capture-to-fission ratios in fast breeder reactor spectra and for recent measurements of the 7Li(n,n't)4He cross section. The tritium extraction facility used for all these experiments has now been calibrated by measuring the 6Li(n,t)4He/197Au/n,γ)198Au activity ratio for thermal neutrons and comparing the result with the well-known cross sections. The calculated-to-measured activity ratio was found to be 1.033 +- 0.018. 2 figures, 20 tables

  6. Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomised trial

    DEFF Research Database (Denmark)

    Regan, M.M.; Lykkesfeldt, A.E.; Dell'Orto, P.;

    2008-01-01

    whether the benefit of letrozole versus tamoxifen differs according to the ERBB2 status of tumours. Methods The BIG 1-98 trial consists of four treatment groups that compare 5 years of monotherapy with letrozole or tamoxifen, and sequential administration of one drug for 2 years followed by the other drug...... according to ERBB2 status of the tumour (p=0.60 for interaction), thus, letrozole improves DFS compared with tamoxifen regardless of ERBB2 status. The observed HRs were 0.62 (95% CI 0.37-1.03) for ERBB2-positive tumours and 0.72 (0.59-0.87) for ERBB2-negative tumours. Interpretation A benefit of letrozole...... over tamoxifen was noted, irrespective of ERBB2 status of the tumour, and, therefore, ERBB2 status does not seem to be a selection criterion for treatment with letrozole versus tamoxifen in postmenopausal women with endocrine-responsive early breast cancer Udgivelsesdato: 2008/1...

  7. SIMS U-Pb, Sm-Nd isotope and geochemical study of an arkosite-amphibolite suite, Peräpohja Schist Belt: evidence for ca. 1.98 Ga A-type felsic magmatism in northern Finland

    Directory of Open Access Journals (Sweden)

    Eero Hanski

    2005-01-01

    Full Text Available In the northern and north-eastern part of the Peräpohja Schist Belt, northern Finland, an extensive supracrustal rock unit has been identified which is composed of alternating amphibolitic and arkositic components. The amphibolites form layers whose thickness varies from one millimeter to some tens of meters, being most often a few tens of centimeters. They represent mafic tuff beds deposited concurrently with more abundant arkositic rocks. Most of the arkosites have a modal and major and trace element compositionsimilar to that of A2-type granites. For example, they exhibit high LREE/HREE, negative Eu anomalies, and flat HREE and are moderately enriched in Nb, Zr, and Y. The genesis of the arkosites is enigmatic as they show features supporting either a volcaniclastic or an epiclastic origin. In the latter case, they were derived via erosion of a source dominated by A2-type granitic rocks. Previous conventional ID-TIMS and new SIMS U-Pb dating of zircons from two arkosite samples and one mica schist sample, all three picked from the northern part of the schist belt, indicate that these rocks contain a single population of zircons with an age of ca. 1975 Ma suggesting that they are among the youngest supracrustal rocks in the schist belt. In contrast, one mica schist sample from the western part of the belt revealed only the presence of Archean zircons. The samples do not differ markedly in terms of their Nd isotopecomposition as they all have a moderately negative εNd(1900 Ma. Regardless of the genesis of the arkosites, their isotopic and geochemical data suggest a previously unknown occurrence of extensive A-type felsic magmatism at ca. 1.98 Ga, contemporaneously withsome continental flood basalts. However, concrete evidence for this felsic A-type magmatism in the form of ca. 1.98 Ga felsic plutonic rocks is virtually absent in the presently exposed Fennoscandian Shield.

  8. Analysis of the Characteristics of HIV Infection Among 1 198 Voluntary Counseling and Testing Cases in Kunming%昆明市1198例自愿咨询检测者HIV感染特征分析

    Institute of Scientific and Technical Information of China (English)

    李钊; 汪永忠; 王仲宁; 陆芸; 雷黎辉

    2011-01-01

    目的 了解接受艾滋病自愿咨询检测者的HIV感染情况及分布特点.方法 收集2006年1月-2007年12月到昆明市疾控中心(CDC)接受艾滋病自愿咨询检测者的HIV检测结果及相关信息,对其人口学及行为相关资料进行分析.结果 共有1 198例进行了HIV检测,48.41%为男性,51.59%为女性;年龄以青壮年为主,20-39岁占82.80%;性接触是求询者的主要危险行为,占92.82%(1 112/1 198);HIV(+)检出率为8.51%(102/1 198);初中以下文化程度的阳性检出率占63.73%(65/102).阳性检出率在10%以上的职业依次为:农民、长卡司机、民工、无业、个体、经商;性接触途径感染的占75.49%(77/102),其中男男同性性接触(MSM)占9.17%(10/109);吸毒者感染率最高,占50.00%(40/80);5.43%(65/1 198)的检测者得到了转介服务.结论 在文化程度相对低的人群,农民、民工等流动性大、低收入人群以及MSM、吸毒者等高危人群中,HIV的感染率相对较高.应加大在这些人群中开展HIV检测的力度,并提高咨询质量,完善转介机制.%Objective To investigate HIV infection situation and distribution characteristics among Volunteer of Counseling and Testing (VCTs). Methods The subjects are those who came to Kunming Center for Disease Control and Prevention to accept counsel and test voluntary from January 2006 to December 2007. HIV test results and the related information of the VCTs' were collected and analysis was done in terms of demography and behavior-related information. Results The HIV test caseload was I 198 ( male: 48.41%; female:51.59% ). The majority of the caseload were young or middle-aged. Those aged from 20 to 39 accounts for 82.80%. 92.82% of the caseload got HIV-infected through sexual contact, and the rate of HIV positive was 8.51% (102/1 198). Among 102 HIV positive people, those who received only junior high school education account for 63.73% (65/102), those who got infected through sexual contact

  9. Study of the potentiometric properties of spinel-type manganese oxide doped with gallium and anions Ga0.02Mn1.98O3.98X0.02 (X = S2− and F−) as selective sensor for lithium ion

    International Nuclear Information System (INIS)

    Highlights: • Investigated the influence of doping agents on the potentiometric response • Reduction of the unit cell size affected directly in the potentiometric performance of the electrode • Sensor performance increased in the order: Ga0.02Mn1.98O4 > Ga0.02Mn1.98O3.98S0.02 > Ga0.02Mn1.98O3.98F0.02. - Abstract: This paper describes the development of a selective lithium ion sensor based on spinel-type manganese oxide doped with gallium and anions (Ga0.02Mn1.98O3.98X0.02, where X = S2− and F−). Investigation was made of the influence of cationic and/or anionic doping agents on the potentiometric response of the sensor. Experimental parameters evaluated included the effect of the lithium concentration on activation of the sensor by cyclic voltammetry, the pH of the electrolyte solution, and the selectivity towards Li+ compared to other alkali and alkaline-earth metal ions. There was an important influence of the unit cell size of the material on the linear range, detection limit, and selectivity of the sensor. Reduction in the size of the tunnel for insertion of the lithium in the porous structure of the oxide directly affected the potentiometric performance of the electrode. Sensor performance increased in the order: Ga0.02Mn1.98O4 > Ga0.02Mn1.98O3.98S0.02 > Ga0.02Mn1.98O3.98F0.02. The observed super-Nernstian response could be explained by a mixed potential arising from two equilibria (redox and ion exchange) in the spinel-type manganese oxide. Sensitivity and the influence of pH on the electrode response were directly related to the doping agents present in the oxide structure

  10. Process for producing astatine-211 for radiopharmaceutical use

    International Nuclear Information System (INIS)

    A one-step chemical manipulation is described in combination with a distillation and collection process for producing At-211 comprising; a. providing a target of irradiated Bismuth coated to a predetermined thickness of a backing member, b. providing a vapor-producing still operably connected with a condenser that has a water cooled condensate collector formed of a dry silica gel mesh maintained at a temperature above the freezing point of water, and providing an effluent gas filter that is operably connected to receive effluent gas from the condenser, c. heating the target in the still at a temperature in the range of about 6300-6800C for a time period in the range of 50 to 80 minutes, to evole At-211 vapor from the target, c. providing a dry carrier gas having an oxygen concentration that is sufficient to form Bi/sub 2/O/sub 3/ thereby to essentially preclude vaporization of Bi metal, passing the carrier gas through the still to carry the At-211 vapor to the condenser, and to carry effluent from the condenser to the effluent gas filter, e. eluting At-211 from the condensate collector of the condenser with a controlled volume of eluent containing predetermined solvents that are compatible with a given desired radiopharmaceutical procedure, and f. collecting the At-211 in the controlled volume of eluent for use in the given radiopharmaceutical procedure

  11. A compact sup 3 H(p,gamma) sup 4 He 19.8 MeV gamma-ray source for energy calibration at the Sudbury Neutrino Observatory

    CERN Document Server

    Poon, A W P; Waltham, C E; Browne, M C; Robertson, R G H; Kherani, N P; Mak, H B

    2000-01-01

    The Sudbury Neutrino Observatory (SNO) is a new 1000-t D sub 2 O Cherenkov solar neutrino detector. A high-energy gamma-ray source is needed to calibrate SNO beyond the sup 8 B solar neutrino endpoint of 15 MeV. This paper describes the design and construction of a source that generates 19.8 MeV gamma rays using the sup 3 H(p,gamma) sup 4 He reaction (''pT''), and demonstrates that the source meets all the physical, operational and lifetime requirements for calibrating SNO. An ion source was built into this unit to generate and to accelerate protons up to 30 keV, and a high-purity scandium tritide target with a scandium-tritium atomic ratio of 1 : 2.0+-0.2 was included. This pT source is the first self-contained, compact, and portable high-energy gamma-ray source (E subgamma>10 MeV). (authors)

  12. QTL Information Table: 198 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Morphological trait Panicle/flower grains/plant RFLP C)Interval RIL Lemont Teqing A G249 RG418 p ... c Loci Are the Primary Genetic Basis of Inbreeding Depression ... and Heterosis in Rice. II. Grain Yield Components. ...

  13. 27 CFR 24.198 - Blending.

    Science.gov (United States)

    2010-04-01

    ... the production of special natural wine of the same type, e.g., producing a sweet vermouth by blending sweet vermouths produced under two or more approved formulas, the submission and approval of...

  14. Preparation of radioactive colloidal gold 198Au

    International Nuclear Information System (INIS)

    The preparation with simple equipment of radioactive colloidal gold of particle size about approximately 300 A from seed colloid stabilized by gelatine is described. Some physico-chemical parameters which can affect the process of formation of these colloidal particles are analysed; particle size has been meassured with an electron microscope. The colloid stability has been studied as a function of dilution, age and pH. Nucleation and growth of radioactive colloidal gold have been studied using spectrophotometry. Absorption spectra of the two ones are presented and compared. Quality control of the production process is verified through measurement of parameters, such as radioactive and radiochemical purity and biological distribution in laboratorial animals. This distribution was evalusted for rats injected endovenously with the gold colloidal solution.(Author)

  15. Measurement of isomeric yield ratios of 197m,gPt and 190m2,g+m1Ir from the 198Pt(γ,n) and natPt(γ,xn1p) reactions induced by 55-, 60-, and 65-MeV bremsstrahlung

    International Nuclear Information System (INIS)

    We have measured the isomeric yield ratios of 197m,gPt from the 198Pt(γ,n) reaction and 190m2,g+m1Ir from the natPt(γ,xn1p) reaction, induced with the bremsstrahlung end-point energies of 55-, 60-, and 65-MeV. The measurements were carried out by the activation method in combination with the direct γ-spectrometry. The experiments were performed at the 100 MeV electron linac of the Pohang Accelerator Laboratory (PAL). The obtained results at 55-, 60- and 65-MeV for the 197m,gPt from the 198Pt(γ,n) reaction are 0.166 ± 0.012, 0.174 ± 0.011, and 0.175 ± 0.011, whereas for the 190m2,g+m1Ir from the natPt(γ,xn1p) reaction are 0.072 ± 0.006, 0.084 ± 0.006 and 0.087 ± 0.006, respectively. The present results are measured for the first time over the investigated energy range. The present data are compared with the similar literature data at lower energy to examine the role of excitation energy

  16. Measurement of isomeric yield ratios of {sup 197m,g}Pt and {sup 190m2,g+m1}Ir from the {sup 198}Pt(γ,n) and {sup nat}Pt(γ,xn1p) reactions induced by 55-, 60-, and 65-MeV bremsstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Kye, Yong-Uk; Shin, Sung-Gyun [Department of Advanced Nuclear Engineering, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Cho, Moo-Hyun [Department of Advanced Nuclear Engineering, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Pohang Accelerator Laboratory, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Kim, Kyung Sook; Namkung, Won [Pohang Accelerator Laboratory, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Kim, Guinyun, E-mail: gnkim@knu.ac.kr [Department of Physics, Kyungpook National University, Daegu 702-701 (Korea, Republic of); Kim, Kwangsoo [Department of Physics, Kyungpook National University, Daegu 702-701 (Korea, Republic of); Kang, Yeong-Rok; Lee, Man-Woo [Research Center, Dongnam Institute of Radiological and Medical Sciences, Busan 619-953 (Korea, Republic of); Yang, Sung-Chul [Department of Physics, Kyungpook National University, Daegu 702-701 (Korea, Republic of); Korea Atomic Energy Research Institute, P.O. Box 105, Yusong, Daejon 305-600 (Korea, Republic of); Nguyen, Van Do; Pham, Duc Khue; Kim, Tien Thanh [Institute of Physics, Vietnam Academy of Science and Technology, 10 Dao Tan, Hanoi (Viet Nam); Naik, Haladhara [Radiochemistry Division, Bhabha Atomic Research Centre, Mumbai 400085 (India)

    2015-05-15

    We have measured the isomeric yield ratios of {sup 197m,g}Pt from the {sup 198}Pt(γ,n) reaction and {sup 190m2,g+m1}Ir from the {sup nat}Pt(γ,xn1p) reaction, induced with the bremsstrahlung end-point energies of 55-, 60-, and 65-MeV. The measurements were carried out by the activation method in combination with the direct γ-spectrometry. The experiments were performed at the 100 MeV electron linac of the Pohang Accelerator Laboratory (PAL). The obtained results at 55-, 60- and 65-MeV for the {sup 197m,g}Pt from the {sup 198}Pt(γ,n) reaction are 0.166 ± 0.012, 0.174 ± 0.011, and 0.175 ± 0.011, whereas for the {sup 190m2,g+m1}Ir from the {sup nat}Pt(γ,xn1p) reaction are 0.072 ± 0.006, 0.084 ± 0.006 and 0.087 ± 0.006, respectively. The present results are measured for the first time over the investigated energy range. The present data are compared with the similar literature data at lower energy to examine the role of excitation energy.

  17. 30 CFR 250.198 - Documents incorporated by reference.

    Science.gov (United States)

    2010-07-01

    ... according to 5 U.S.C. 552(a) and 1 CFR part 51. (1) Incorporation by reference of a document is limited to....1202(a)(3), (l)(4); (28) API MPMS, Chapter 9—Density Determination, Section 2—Standard Test Method for...(a)(3), (l)(4); (30) API MPMS, Chapter 10—Sediment and Water, Section 2—Standard Test Method...

  18. 27 CFR 41.198 - Investigation of applicant.

    Science.gov (United States)

    2010-04-01

    ... felony violation of any other provision of Federal criminal law relating to tobacco products, processed... chapter; (b) Has been convicted of a felony violation of any provision of Federal or State criminal...

  19. Tritium removal from inert gases using ST 198 alloy

    International Nuclear Information System (INIS)

    Tritium handling invariably requires multiple containment to ensure personnel safety and to control emissions to the environment. For this measure to be effective, tritiated environments require periodic or continuous tritium removal. Currently, this is primarily achieved by the conventional method of catalytic oxidation of tritium bearing compounds followed by adsorption of tritiated water on molecular sieves. An experimental program was initiated to examine the potential of a metal getter detritiation process. The tritium removal characteristics of a zirconium-iron alloy, Zr2Fe, which is essentially chemically inert in nitrogen at operating temperatures of approximately 300-400 degrees C, were studied. Over 50 tritium removal tests were reproducibly conducted and the following results emerged: the zirconium alloy getter, operating at a mean temperature of 360 degrees C, is found to effectively remove tritium from nitrogen and noble gases to levels of a few μCi/m3 for initial concentrations of approximately 1300 μCi/m3 or less. In the cases of higher initial tritium concentrations, the removal is not complete, probably a consequence of getter history. The performance of the alloy is not highly sensitive to the presence of impurities. The getter effectively absorbs the impurities CO, O2 and NH3, while the impurity methane is not removed noticeably

  20. 37 CFR 1.98 - Content of information disclosure statement.

    Science.gov (United States)

    2010-07-01

    ... identified by the country or patent office which issued the patent or published the application, an... must be identified by inventor, patent number, and issue date. (2) Each U.S. patent application... statement must be identified by the inventor, application number, and filing date. (4) Each foreign...

  1. Adolescent idiopathic scoliosis and melatonin: a survey on scoliosis in 8 198 adolescents from over 10 middle and primary schools in Haikou City%青少年脊柱侧凸畸形与褪黑素:海口市10余所城乡中小学8198名青少年普查结果分析

    Institute of Scientific and Technical Information of China (English)

    张寿; 金旭红; 梁宁; 邢势; 林尤仁; 王伟

    2005-01-01

    背景:对于褪黑素是否与特发性脊柱侧凸(AIS)的发病机制有关,目前国内外学者研究结果尚无统一认识.目的:探讨青少年脊柱侧凸发病机制与褪黑素的关系及作用.设计:两检筛选法普查及非随机化同期对照研究.单位:海口市人民医院骨二科.对象:实验在海口市人民医院骨二科完成.调查海府地区10余所城乡中小学8 198名7~16岁在校学生,其中男4 423名,女3 775名.方法:选择普查中被诊断为AIS患儿42名,随机抽取50名正常人做对照,用放免法进行褪黑素测定与统计学处理.主要观察指标:两组调查者血清褪黑素含量.结果:青春前期10岁前年龄段AIS男女初始组褪黑素含量均低于青春期组及正常组,尤以女性为显,具有高度统计学意义.结论:血清中褪黑素与脊柱侧凸的发病机制有关.%BACKGROUD: It is not consistent on whether melatonin correlates with the adolescent idiopathic scoliosis(AIS) demonstrated by the domestic and foreign scholars.OBJECTIVE: To study the pathogenesis of AIS and its correlation with melatonin.DESIGN: A nonrandomized age-matched controlled study screened with two tests.SETTING: The Second Department of Orthopaedics, Haikou People' s Hospital.PARTICIPANTS: The experiment was completed in the Second Department of Orthopaedics, Haikou People' s Hospital. Totally 8 198 in-school students.from over 10 schools of towns in Haifu District, 4 423 males and 3 775 females, aged 7 to 16 years were surveyed.METHODS: Forty-two adolescents who have been diagnosed with AIS were selected and 50 healthy age-matched adolescents were selected as controls. Melatonin was assayed with the radioimmunology and the data were processed statistically.MAIN OUTCOME MEASURES: The levels of serum melatonin in the two groups.RESULTS: The serum melatonin of the preadolescents below 10 years old in AIS group, especially of females, was less than that of adolescents in the control group, with significant

  2. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  3. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  4. Astatination of nanoparticles containing silver as possible carriers of 211At

    Czech Academy of Sciences Publication Activity Database

    Lebeda, Ondřej; Kučka, Jan; Hrubý, Martin; Koňák, Čestmír; Kozempel, Ján

    2006-01-01

    Roč. 64, - (2006), s. 201-206. ISSN 0969-8043 R&D Projects: GA AV ČR KJB4048302; GA AV ČR KJB4050408 Institutional research plan: CEZ:AV0Z1048901 Keywords : nanoparticles * 211AT * Atalpha particle therapy Subject RIV: CH - Nuclear ; Quantum Chemistry Impact factor: 0.924, year: 2006

  5. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  6. People and things. CERN Courier, Nov 1979, v. 19(8)

    International Nuclear Information System (INIS)

    The article covers the celebration of the 'Journée du Personnel' (Staff Day), where over 3000 CERN staff turned up to enjoy various attractions like games, sports, sideshows, competitions, films, music and entertainment, and dancing that went on into the small hours. One highlight was the playing of 'Happy Birthday, CERN — From Fermi lab', recorded at Fermi lab. In other news, the article reports on various people, staff changes within the CERN organization and recent news updates

  7. Yeast Interacting Proteins Database: YDR425W, YGL198W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YDR425W SNX41 Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi ... endosome to the trans-Golgi network ; interacts with Snx4p Rows with this bait as bait ... Es from the post-Golgi endosome to the trans-Golgi network ; interacts with Snx4p Rows with this bait as bait ...

  8. Yeast Interacting Proteins Database: YPL095C, YGL198W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YPL095C EEB1 Acyl-coenzymeA:ethanol ... O-acyltransferase responsible for the major part of medium-c ... ait gene name EEB1 Bait description Acyl-coenzymeA:ethanol ... O-acyltransferase responsible for the major part o ...

  9. Slim 198gold-grain implanter loaded with standard royal marsden 14-grain magazines

    International Nuclear Information System (INIS)

    We designed a slim gold-grain implanter with adaptable lengths to implant areas accessible only through long, narrow, examining instruments, such as a suspension laryngoscope. The implanter is loaded with the same 14-grain magazine designed for and supplied with the Royal Marsden gun. The simplicity of the loading mechanism with a minimum of moving parts makes the instrument practically trouble free. Although it is designed to be used along narrow examining instruments, it can also be used in any situation in which a permanent implant is required, for instance, prostatic cancer and pelvic recurrences in cancer of the uterine cervix previously treated by external and intracavitary irradiation

  10. 40 CFR 267.198 - What are the general operating requirements for my tank systems?

    Science.gov (United States)

    2010-07-01

    ... system if they could cause the tank, its ancillary equipment, or the containment system to rupture, leak... comply with the requirements of § 267.200 if a leak or spill occurs in the tank system....

  11. Indoor air quality: Carbon monoxide, molds and beyond. Current issue paper number 198

    International Nuclear Information System (INIS)

    This paper provides an overview of several of the major indoor air pollutants and some of the ways in which indoor air quality is addressed by governments in the United States and Canada. The emphasis is on non-industrial settings. Pollutants discussed include carbon dioxide, tobacco smoke, radon, carbon monoxide, nitrogen dioxide, wood smoke and particles, volatile organic compounds, and molds

  12. Treatment of Synthetic Wastewater Containing Reactive Red 198 by Electrocoagulation Process

    OpenAIRE

    N.M Mahmoodi; Ameri, A.; Gholami, M.; A Jonidi jafari; A Dalvand

    2011-01-01

    "nBackground and Objectives: Discharge of textile colored wastewater industries without providing enough treatment in water bodies, is harmful for human and aquatic organisms and poses serious damages to the environment. Most of conventional wastewater treatment methods don't have enough efficiency to remove textile dyes from colored wastewater; thus in this research the efficiency of electrocoagulation treatment process with aluminum electrodes for treatment of a synthetic wastewater co...

  13. International Spread of an Epidemic Population of Salmonella enterica Serotype Kentucky ST198 Resistant to Ciprofloxacin

    DEFF Research Database (Denmark)

    Le Hello, Simon; Hendriksen, Rene S.; Doublet, Benoit;

    2011-01-01

    National Salmonella surveillance systems from France, England and Wales, Denmark, and the United States identified the recent emergence of multidrug-resistant isolates of Salmonella enterica serotype Kentucky displaying high-level resistance to ciprofloxacin. A total of 489 human cases were ident...

  14. 198 "Viviendas dinámicas sin deuda" en Valdivia, X Región, Chile

    Directory of Open Access Journals (Sweden)

    Bonet Miró, Ana

    2007-06-01

    Full Text Available The purpose of the competition as well as the project developed in response to the social, constructive and climate specific conditions of Valdivia, X Region, Chile, is the design and construction of experimental social housing, whose cost, including land and services, would not exceed 7,500 $ per unit. The housing units should be designed in order to grow and to be adapted by owners and should allow for achieving higher urban density as average so to reduce the burden of costs derived from land acquisition and services. The project adopts a three-storey compact typology such as a “big house”, with 2 units on ground floor and 4 duplex on upper floors. The local wood construction tradition and the good level of acceptance of it within the context of Valdivia, bring us to develop a mixed construction system, concrete and wood, which not only is suitable to the geotechnical and seismic conditions of the ground, but also to the economical restrictions and to the requirements of spatial flexibility so necessary when designing a minimal housing unit.El objetivo del concurso y del proyecto desarrollado posteriormente, adaptado a los condicionantes sociales, constructivos y climatológicos de Valdivia, X Región, Chile, es el diseño y construcción de unas viviendas sociales experimentales, cuyo coste, incluida la repercusión del suelo no exceda de 7.500 $ por unidad. Dichas viviendas tienen que ser aptas para su crecimiento y adaptación posterior y lograr una mayor densidad que las habitualmente conseguidas en estos programas con el fin de abaratar los costos derivados de la compra del terreno. Se adopta una tipología compacta de “casa grande”, de tres alturas, con 2 viviendas en planta baja y 4 dúplex en las plantas superiores. La tradición constructiva local en madera y la buena aceptación que la misma tiene en el contexto de Valdivia han llevado a proponer un sistema mixto, hormigón y madera que no sólo responde bien a los condicionantes geotécnicos y sísmicos del solar y a las limitaciones económicas sino también a la flexibilidad espacial necesaria en un proyecto de vivienda mínima.

  15. Interplay between pulsations and mass loss in the blue supergiant 55 Cygnus = HD 198 478

    Czech Academy of Sciences Publication Activity Database

    Kraus, Michaela; Haucke, M.; Cidale, L.S.; Venero, R.O.J.; Nickeler, Dieter Horst; Németh, P.; Niemczura, E.; Tomić, S.; Aret, A.; Kubát, Jiří; Kubátová, Brankica; Oksala, Mary E.; Curé, M.; Kaminski, K.; Dimitrov, W.; Fagas, M.; Polinska, M.

    2015-01-01

    Roč. 581, September (2015), A75/1-A75/22. ISSN 0004-6361 Institutional support: RVO:67985815 Keywords : early-type stars * supergiants * winds Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 4.378, year: 2014

  16. Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

    Energy Technology Data Exchange (ETDEWEB)

    Green, Damian J.; Shadman, Mazyar; Jones, Jon C.; Frayo, Shani; Kenoyer, Aimee L.; Hylarides, Mark; Hamlin, Donald K.; Wilbur, D. Scott; Balkan, Ethan R.; Lin, Yukang; Miller, Brian W.; Frost, Sophia; Gopal, Ajay K.; Orozco, Johnnie J.; Gooley, Ted; Laird, Kelley L.; Till, B. G.; Back, Tom; Sandmaier, B. M.; Pagel, John M.; Press, Oliver W.

    2015-03-26

    Alpha emitting radionuclides release a large amount of energy within a few cell diameters and may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD) conditions in which micrometastatic disease satellites are broadly distributed. To evaluate this hypothesis, 211At conjugated 1F5 mAb (anti-CD20) was studied in both bulky lymphoma tumor xenograft and MRD animal models. Superior treatment responses to 211At conjugated 1F5 mAb were evident in the MRD setting. Lymphoma xenograft tumor bearing animals treated with doses of up to 48µCi of anti-CD20 211At-decaborate [211At-B10-1F5] experienced modest responses (0% cures but 2-3-fold prolongation of survival compared to negative controls). In contrast, 70% of animals in the MRD lymphoma model demonstrated complete eradication of disease when treated with 211At-B10-1F5 at a radiation dose that was less than one-third (15 µCi) of the highest dose given to xenograft animals. Tumor progression among untreated control animals in both models was uniformly lethal. After 130 days, no significant renal or hepatic toxicity is observed in the cured animals receiving 15 µCi of 211At-B10-1F5. These findings suggest that in a MRD lymphoma model, where isolated cells and tumor microclusters prevail, α-emitters may be uniquely efficacious.

  17. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE,CERN

    OpenAIRE

    Rothe, Sebastian

    2012-01-01

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spec...

  18. Inactivation of human osteosarcoma cells in vitro by {sup 211}At-TP-3 monoclonal antibody: Comparison with astatine-211 and external-beam X rays

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, R.H. [Univ. of Oslo (Norway)]|[Institute for Cancer Research, Oslo (Norway); Bruland, O.S. [Institute for Cancer Research, Oslo (Norway); Hoff, P.; Alstad, J. [Univ. of Oslo (Norway); Lindmo, T. [Institute for Cancer Research, Oslo (Norway); Rofstad, E.K. [Norwegian Institute of Technology, Trondheim (Norway)

    1994-08-01

    The potential usefulness of {alpha}-particle radioimmunotherapy in the treatment of osteosarcoma was studied in vitro by using the monoclonal antibody TP-3 and cells of three human osteosarcoma cell lines (OHS, SAOS and KPDX) differing in antigen expression. Cell survival curves were established after treatment with (a) {sup 211}At-TP-3 of different specific activities, (b) {sup 211}At-labeled bovine serum albumin (BSA), (c) free {sup 211}At and (d) external-beam X rays. The three osteosarcoma cell lines showed similar survival curves, whether treated with external-beam X rays, {sup 211}At-BSA or free {sup 211}At. The D{sub o}`s were lower for free {sup 211}At than for {sup 211}At-BSA. The survival curves for {sup 211}At-TP-3 treatment, on the other hand, differed significantly among the cell lines, suggesting that sensitivity to {sup 211}At-TP-3 treatment was governed by cellular properties other than sensitivity to external-beam X rays. The cellular property most important for sensitivity to {sup 211}At-TP-3 treatment was the antigen expression. Cell inactivation after {sup 211}At-TP-3 treatment increased substantially with increasing specific activity of the {sup 211}At-TP-3. At high specific activities, the cytotoxic effect of {sup 211}At-TP-3 was significantly higher than that of {sup 211}At-BSA. In conclusion, {sup 211}At-TP-3 has the potential to give clinically favorable therapeutic ratios in the treatment of osteosarcoma. 39 refs., 5 figs., 2 tabs.

  19. Sepetiba Harbour Dredging Studies Using 198Au - Brazil [Case Study: Radiotracer Applications for Investigation of Suspended Sediment Transport

    International Nuclear Information System (INIS)

    Sepetiba Bay is situated in the southeastern region of Brazil, at 100 km west from Rio de Janeiro, with approximate dimensions of 25 km (E-W) and 12.5 km (N-S). It is well protected from wave action from open sea by a barrier beach with about 40 km in a E-W direction, ending in Marambaia Hill (Fig. 74). The main entrance is located in its western side through passageways and channels between the mainland and several islands. In terms of water circulation the shallow eastern entrance is unimportant. Local tides are semi-diurnal, with maximum spring tidal range of 1.5 m. Sea waves generated by local winds do not exceed 0.8 m, having short periods (2 to 3 s). Maximum wind velocities amount to 10 m/s and occur in the winter months when it blows from southerly directions. In general, mean wind velocities ranges from 3 to 5 m/s. There is no stratification in the water column inside the bay and the tide is the main hydrodynamic agent governing the weak currents (< 0.5 m/s) occurring inside the bay, which have a predominant W-E direction in the flood tide phase, and E-W during the ebb tide. Silt is the dominant material on the bottom of Sepetiba Bay. An iron-ore and coal terminal was built in the 70’s in Sepetiba Bay and it was necessary to dredge 10x106 m3 of fine material for the establishment of an approach channel, turning basin and dock site (dredged region). For the dredging works, trailing suction hopper dredgers (TSHD) with carrying capacity of 4000 m3 were employed. The Navy Authority determined that the dumping site should be situated outside Sepetiba Bay, at E of Ilha Grande. For dumping at that place it was necessary around 5 hours for a round trip of the dredge, only to transport the dredged material, not taking into account the dredging time

  20. Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial

    DEFF Research Database (Denmark)

    Metzger Filho, Otto; Giobbie-Hurder, Anita; Mallon, Elizabeth;

    2015-01-01

    PURPOSE: To evaluate the relative effectiveness of letrozole compared with tamoxifen for patients with invasive ductal or lobular carcinoma. PATIENTS AND METHODS: Patients diagnosed with early-stage invasive ductal carcinoma (IDC) or classic invasive lobular carcinoma (ILC) who were randomly...

  1. Kinetic study of adsorption and photo-decolorization of Reactive Red 198 on TiO2 surface

    OpenAIRE

    Dutta, S.; Parsons, Simon A.; Bhattacharjee, C.; Jarvis, Peter; Datta, S.; Bandyopadhyay, S

    2009-01-01

    Recycling and reuse of wastewater after purification will reduce the environmental pollution as well as fulfill the increasing demand of water. Adsorption-based water treatment process is very popular for dye-house wastewater treatment. The present study deals with treatment of wastewater contaminated by reactive dye. TiO2 is used as adsorbent and the spent adsorbent has been regenerated by Advanced Oxidation Process (AOP), without using any other chemicals. TiO2 adsorbs dye molecules and the...

  2. Occupational irradiation by external radiation sources. Analysis of the control system data covering the period 1972 - 198a

    International Nuclear Information System (INIS)

    Occupational irradiation data, made available by the system of individual dosimetric control, are analyzed. It is demonstrated that the annual dose distribution is in accordance with the logarithm of normal distribution. The obtained values of the average dose in industry, medicine, science and educatuin during the period 1972 through 1980 are respectively 3.7 mSv, 1.0 mSv and 0.45 mSv. In some lines the average annual dose considerably exceeds the average annual dose for the respective branch, e.g. for workers in gamma defectoscopy it amounts to 9.1 mSv, while for medical personnel of deep and curi therapy - 2.1 mSv. (author)

  3. Outcomes of special histotypes of breast cancer after adjuvant endocrine therapy with letrozole or tamoxifen in the monotherapy cohort of the BIG 1-98 trial

    DEFF Research Database (Denmark)

    Munzone, E; Giobbie-Hurder, A; Gusterson, B A;

    2015-01-01

    cohort (5 years of therapy with tamoxifen or letrozole) included 4922 women, of whom 4091 had central pathology review. Histotype groups were defined as: mucinous (N = 100), tubular/cribriform (N = 83), ductal (N = 3257), and other (N = 651). Of 183 women with either mucinous or tubular/cribriform tumors......, 96 were randomly assigned to letrozole and 87 to tamoxifen. Outcomes assessed were disease-free survival (DFS), overall survival (OS), breast cancer-free interval (BCFI), and distant recurrence-free interval (DRFI). Median follow-up in the analytic cohort was 8.1 years. RESULTS: Women with tubular...... (5-year rates 97.8% and 98.8%, respectively) than those with ductal (90.9%) or other (92.1%) carcinomas. Within the subgroup of women with special histotypes, we observed a nonsignificant increase in the hazard of breast cancer recurrence with letrozole [hazard (letrozole versus tamoxifen): 3.31, 95...

  4. Analyses adjusting for selective crossover show improved overall survival with adjuvant letrozole compared with tamoxifen in the BIG 1-98 study

    DEFF Research Database (Denmark)

    Colleoni, Marco; Giobbie-Hurder, Anita; Regan, Meredith M;

    2011-01-01

    Among postmenopausal women with endocrine-responsive breast cancer, the aromatase inhibitor letrozole, when compared with tamoxifen, has been shown to significantly improve disease-free survival (DFS) and time to distant recurrence (TDR). We investigated whether letrozole monotherapy prolonged...... overall survival (OS) compared with tamoxifen monotherapy....

  5. The advantage of letrozole over tamoxifen in the BIG 1-98 trial is consistent in younger postmenopausal women and in those with chemotherapy-induced menopause

    DEFF Research Database (Denmark)

    Chirgwin, Jacquie; Sun, Zhuoxin; Smith, Ian;

    2012-01-01

    subclinical ovarian estrogen production), and those with chemotherapy-induced menopause who may experience return of ovarian function. In these situations tamoxifen may be preferable to an aromatase inhibitor. Among 4,922 patients allocated to the monotherapy arms (5 years of letrozole or tamoxifen) in the...

  6. Intestinal-type of differentiation predicts favourable overall survival: confirmatory clinicopathological analysis of 198 periampullary adenocarcinomas of pancreatic, biliary, ampullary and duodenal origin

    OpenAIRE

    Bronsert, Peter; Kohler, Ilona; Werner, Martin; Makowiec, Frank; Kuesters, Simon; Hoeppner, Jens; Hopt, Ulrich Theodor; Keck, Tobias; Bausch, Dirk; Wellner, Ulrich Friedrich

    2013-01-01

    Background Periampullary adenocarcinomas comprise pancreatic, distal bile duct, ampullary and duodenal adenocarcinoma. The epithelia of these anatomical structures share a common embryologic origin from the foregut. With steadily increasing numbers of pancreatoduodenectomies over the last decades, pathologists, surgeons and oncologists are more often confronted with the diagnosis of “other than pancreatic” periampullary cancers. The intestinal subtype of ampullary cancer has been shown to cor...

  7. Study of the seasonal variation in the exchanges of food labelled with 198Au from a worker bee to a queen (Apis mellifica ligustica S.)

    International Nuclear Information System (INIS)

    Food exchanges from a worker giver to a queen receiver were quantified throughout the year. 4 days old workers distribute great amounts of food to queens, about 74% in average, but variations are low. On the other hand workers of unknown age distribute amounts that are less high and varying in terms of the season. A parallelism exists between percentage variations of food shared by workers of unknown age and the seasonal cycle of the 9-oxodec-2-enoic acid content of queens

  8. CYP19A1 polymorphisms and clinical outcomes in postmenopausal women with hormone receptor-positive breast cancer in the BIG 1-98 trial

    DEFF Research Database (Denmark)

    Leyland-Jones, Brian; Gray, Kathryn P; Abramovitz, Mark; Bouzyk, Mark; Young, Brandon; Long, Bradley; Kammler, Roswitha; Dell'Orto, Patrizia; Biasi, Maria Olivia; Thürlimann, Beat; Lyng, Maria Bibi; Ditzel, Henrik J; Harvey, Vernon J; Neven, Patrick; Treilleux, Isabelle; Rasmussen, Birgitte Bruun; Maibach, Rudolf; Price, Karen N; Coates, Alan S; Goldhirsch, Aron; Pagani, Olivia; Viale, Giuseppe; Rae, James M; Regan, Meredith M

    2015-01-01

    To determine whether CYP19A1 polymorphisms are associated with abnormal activity of aromatase and with musculoskeletal and bone side effects of aromatase inhibitors. DNA was isolated from tumor specimens of 4861 postmenopausal women with hormone receptor-positive breast cancer enrolled in the BIG...

  9. Corrigendum to "An equation decoupling approach to identify the equivalent foundation in rotating machinery using modal parameters" [J. Sound Vib. 365 (2016) 182-198

    Science.gov (United States)

    Yu, Minli; Feng, Ningsheng; Hahn, Eric J.

    2016-08-01

    The authors would like to apologise for the error made to the affiliation details of Dr Ningsheng Feng and Dr Eric J. Hahn in the original publication and who are both affiliated to The School of Mechanical and Manufacturing Engineering, The University of New South Wales, Sydney, NSW 2052, Australia

  10. Surface modification of the core-shell type 198Au SiO2 Nano particles for an organic process media tracing study in refinery/petrochemical industries

    International Nuclear Information System (INIS)

    In this study, the surface of the Au SiO2 nano particle was modified from a hydrophilic type to hydrophobic by introducing 3,5-diphenylisocyanate in order to make use of the particle as a radiotracer in the flow dynamics study for petrochemical process units. The partitioning ratio of the hydrophobic particles between water and toluene was measured and compared as a function of time. It was observed that the partitioning ratio into an organic phase has been dramatically increased after the surface modification reaction. Consequently, the potential of its applicability to petrochemical: process diagnosis was enhanced

  11. Preparation and identification of activity of anti-HPV-6b/llE1 universal ribozyme--Rzl198 in vitro

    Institute of Scientific and Technical Information of China (English)

    De-Zhong; You-XinJIN; Huahou; Yang-ZhongHUANG

    1999-01-01

    Aim: To study the preparation and cleavage activity of Rz1198 directed against HPV-6bE1 and HPV-11E1 (HPV-6b/llE1) transcripts in vitro. Methods: HPV-6b/llE1 gene fragments were cloned into T-vector trader the control ofT7 promoter, 32P-tabeled HPV-6b/I1E1 transcripts as target-RNAs were transcribed in vitro and purified by PAGE.

  12. Cruise report for a seismic investigation of gas hydrates in the Mississippi Canyon region, northern Gulf of Mexico; cruise M1-98-GM

    Science.gov (United States)

    Cooper, Alan K.; Hart, Patrick E.; Pecher, Ingo

    1998-01-01

    During June 1998, the U.S. Geological Survey (USGS) and the University of Mississippi Marine Minerals Technology Center (MMTC) conducted a 12-day cruise in the Mississippi Canyon region of the Gulf of Mexico (Fig. 1). The R/V Tommy Munro, owned by the Marine Research Institute of the University of Southern Mississippi, was chartered for the cruise. The general objective was to acquire very high resolution seismic-reflection data across of the upper and middle continental slope (200-1200-m water depths) to study the acoustic character, distribution and potential effects of gas hydrates within the shallow subsurface, extending from the sea floor down to the base of the gas-hydrate stability zone. The Gulf of Mexico is well known for hydrocarbon resources that include petroleum and related gases. Areas of the Gulf that lie in waters deeper than about 250 m potentially have conditions (e.g., pressure, temperature, near-surface gas content, etc.) that are right for the shallow-subsurface formation of the ice-like substance (gas and water) known as gas hydrate (Kvenvolden, 1993). Gas hydrates have previously been sampled in sea-floor cores and observed as massive mounds in several parts of the northern Gulf, including the Mississippi Canyon region (e.g., Anderson et al., 1992). Extensive seismic data have been recorded in the Gulf, in support of commercial drilling efforts, but few very high resolution data exist in the public domain to aid in gas-hydrate studies. Studies of long-term interest include those on the resource potential of gas hydrates, the geologic hazards associated with dissociation and formation of hydrates, and the impact, if any, of gas-hydrate dissociation on atmospheric warming (i.e., via release of methane, a "greenhouse" gas). Several very high resolution seismic systems (surface-towed, deep-towed, and sea-floor) were used during the cruise to test the feasibility of using such data for detailed structural (geometric) and stratigraphic (physical property) analyses based on the acoustic data. The cruise was conducted in two regions, on opposite flanks of the Mississippi Canyon, where gas hydrates are known and suspected from prior coring and seismic operations (e.g., Neurauter and Bryant, 1989). The regions are also characterized by thick surficial, relatively young (Pleistocene and younger) sediments. Swath-bathymetry data (Fig. 2) show extensive sea-floor faults, piercement features, and slumps—features whose development could potentially be related to gas hydrates. The specific objectives of the cruise were (a) to image the gas-hydrate stability zone across the continental margin to document bottom-simulating reflections (BSRs) and changes in geometry of the hydrate stability zone; (b) to image known hydrate features (with several seismic systems) to estimate physical properties for hydrate and non-hydrate areas; (c) to outline the shallow structures of the hydrate stability zone to ascertain their potential effects on the formation/distribution of hydrates and on stability of the sea floor; and (d) to estimate, if possible, the amounts of hydrates present in the shallow sub surface.

  13. Study of food transfers in drones (Apis mellifica ligustica S.) by means of a radio-isotope 198Au during the year. Comparison between the three castes

    International Nuclear Information System (INIS)

    Food transfers from a radioactive donor worker bee to a receiving drone, of which age is known, were studied all through the year. Results are compared with those of both other castes. Amounts of food shared and homogeneity of food exchanges are different according to the category to which the worker bee belongs. The seasons have an effect only upon the feeding behavior of worker Bees of unknown age. It appears that the drone is an insect whose feeding behavior is situated between that of a queen and that of a worker from the point of view of food exchanges. The interest of winter drones is emphasized

  14. The treatment of rheumatoid arthritis, osteoarthritis, and non-specific synovitis by intra-articular injection of radioactive colloidal gold (198Au)

    International Nuclear Information System (INIS)

    In this study, thirty-nine knee and three ankle effusions and pains unresponsive to the usual methods of therapy were treated by intra-articular injection of radioactive colloidal gold from November 1964 to January 1979 and followed up. Thirteen cases had classical rheumatoid arthritis: fifteen non-specific synovitis: two pigmented villonodular synovitis: one post-synovectomy, and one tuberculous arthritis. The results were as follows: 1) In eleven cases (84.6 %) of rheumatoid arthritis fourteen cases (93.3 %) of non-specific synovitis, and five cases (50.0 %) of osteoarthritis, the effusion disappeared. 2) In twelve cases (92.3 %) of rheumatoid arthritis, thirteen cases (86.7 %) of non-specific synovitis, and only two cases (20.0 %) of oseoarthritis, the pain disappeared. 3) As a whole, in thirty-three cases (78.6 %), the effusion disappeared and in twenty-eight cases (66.7 %) the pain disappeared. (author)

  15. SU-E-T-198: Hippocampal-Sparing Radiotherapy (HSRT) for Patients with Head and Neck Cancer (HNC) Using Intensity-Modulated Radiation Therapy (IMRT)

    Energy Technology Data Exchange (ETDEWEB)

    Dunlop, A; Welsh, L; Nutting, C; Harrington, K; Bhide, S; Newbold, K

    2014-06-01

    Purpose: There is increasing evidence that decline in cognitive function following brain radiotherapy (RT) is related to the radiation dose delivered to the hippocampi. In this work we evaluate the feasibility of using IMRT to generate HSRT plans in HNC. Methods: A planning study was undertaken for ten representative patients with HNC previously treated with radical (chemo)-RT using standard IMRT techniques. The hippocampi were delineated according to the RTOG hippocampal contouring atlas, on a T1w- MRI scan that was registered with the RT planning CT. LINAC-based, clinically acceptable, HSRT plans were generated and assessed using the Pinnacle3 treatment planning system. Results: Using a VMAT technique, a reduction in hippocampal dose was achievable in six cases. For these cases, the EQD2-D40% of the bilateral hippocampi was significantly reduced by HSRT (p = 0.006) from a median of 18.8Gy (range 14.4–34.6) to 6.5 Gy (4.2–9.5) for the delivered and HSRT plans respectively. Plans were also generated using a fixed-field IMRT technique with non-coplanar beams that were designed to avoid the bilateral hippocampi, resulting in a median EQD2-D40% of 11.2Gy (8.0–14.5). Both HSRT techniques also resulted in lower doses to the whole brain, brain stem, and cerebellum. The HSRT plans resulted in higher doses to some regions of non-contoured normaltissue, but the magnitude of these dose differences is unlikely to be of clinical significance in terms of acute and late toxicity. Conclusion: This study has demonstrated that it is possible, in many cases, to adapt treatment plans for HNC to significantly reduce dose to the hippocampi. This reduction in dose would be predicted to Resultin a significant reduction in the probability of subsequent decline in cognitive function following RT. Our results point towards the need for the collection of prospective data on cognitive outcomes for the HNC patient population treated with radical (chemo)-RT.

  16. Look for Feelings and True Love in Virtual World-Sociological Interpretation of 198 Pairs of Women's Internet Dating Texts%寻找虚拟世界的情感与真爱--对198则女性网络征婚文本的社会学解读

    Institute of Scientific and Technical Information of China (English)

    徐超

    2009-01-01

    网络征婚相对于报刊、杂志征婚的"干巴巴"而显得"有血有肉",征婚内容(字数)没有限制而且还可以上传照片,这是网络征婚特点所在.对包括未婚者、离异者、丧偶者征婚内容的分析,阐述在年龄结构既定条件下户口所在地与现居住地、征婚地点、婚房问题等都对女性网络征婚产生重大影响,证明婚房是女性征婚世界中的头等大事;征婚青年女性在发生人口流动情况下,倾向把征婚地点限定为现居住地;离异者、丧偶者对征婚地点一般没有限定.

  17. Incomensurabilidade e complementaridade: diálogo de saberes e a questão socioambiental - DOI: 10.4025/actascihumansoc.v27i2.198 Uncountability and complementarity: dialogue between knowledge and the socio-environmental question - DOI: 10.4025/actascihumansoc.v27i2.198

    Directory of Open Access Journals (Sweden)

    José Edmilson de Souza-Lima

    2005-11-01

    Full Text Available O presente artigo verifica e explicita algumas possibilidades de se pensar uma epistemologia da convergência como estratégia analítica da problemática socioambiental. Para tanto, recorre-se a alguns instrumentos da hermenêutica para demonstrar que a dicotomia reducionismo/holismo é falsa, mas que tem-se projetado como fator fundante da maioria das epistemologias da modernidade. Conclui que reducionismo e holismo são faces de um projeto único de construção da epistemologia da convergência.Current article verifies the possibilities of elaborating an epistemology of convergence as an analytical strategy of the socio-environmental subject. Hermeneutics are used to demonstrate that the dichotomy between reductionism/holism is an error, even though it is a main factor of the most modern epistemologies. Reductionism and holism are faces of an unique project writhin the epistemology of convergence.

  18. Shelf-Life of ɛ-Lysyl-3-(Trimethylstannyl)Benzamide Immunoconjugates, Precursors for 211At Labeling of Antibodies

    OpenAIRE

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per; Jensen, Holger; Holgersson, Stellan; Lindegren, Sture

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity and the complex radiochemistry of 211At are major obstacles for research and prospective clinical applications. In the present study, astatination of immunoconjugates, already prepared well in advance...

  19. El último eslabón en el respeto a la identidad y orientación sexual: análisis de la STC 198/12 sobre matrimonio entre personas del mismo sexo

    OpenAIRE

    Torres Núñez, Jesús

    2015-01-01

    El reconocimiento del matrimonio entre personas del mismo sexo llevado a cabo por la Ley 13/2005 de 1 de julio, es el resultado de una larga evolución histórica no sólo de la institución matrimonial, sino también de los derechos de aquellas personas que por su orientación sexual, identidad sexual y/o género bien se han visto perseguidas en otras etapas de nuestra historia, tal y como se reconoce incluso en la Ley de la Memoria Histórica, o bien han visto limitados sin más su...

  20. María Cristina Menéndez. Política y medios : Editorial La Crujía, 2009, 198 páginas

    OpenAIRE

    Tram[p]as de la Comunicación y la Cultura

    2009-01-01

    Esta obra se ubica en un punto de intersección disciplinaria en el campo de las ciencias sociales, en las fronteras entre la ciencia política y la teoría de la comunicación, brindando una perspectiva compleja acerca de la relación entre democracia, opinión pública y medios de comunicación. Realiza, como punto inicial, un rastreo del pensamiento de fi lósofos políticos sobre la relación entre política y opinión pública. (Párrafo extraído del texto a modo de resumen)

  1. Thermosalinograph Data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT189-198 during 2007 (NODC Accession 0048896)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  2. CTD Data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT189-198 during 2007 (NODC Accession 0048725)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  3. Niskin Bottle Data of the Hawaii Ocean Time-series (HOT) program in the North Pacific 100 Miles North of Oahu, Hawaii for Cruises HOT189-198 during 2007 (NODC Accession 0048660)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The HOT program makes repeated observations of the physics, biology and chemistry at a site approximately 100 km north of Oahu, Hawaii. Two stations are visited...

  4. Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up

    DEFF Research Database (Denmark)

    Regan, Meredith M; Neven, Patrick; Giobbie-Hurder, Anita;

    2011-01-01

    Postmenopausal women with hormone receptor-positive early breast cancer have persistent, long-term risk of breast-cancer recurrence and death. Therefore, trials assessing endocrine therapies for this patient population need extended follow-up. We present an update of efficacy outcomes in the Breast...

  5. Effective height development of four co-occurring species in the gap-phase regeneration of Douglas fir monocultures under nature-oriented conversion. Forest Ecology and Management, Pages 189-198

    NARCIS (Netherlands)

    Dekker, M.; Breugel, van M.; Sterck, F.J.

    2007-01-01

    Natural regeneration in gaps in Douglas fir forest stands in the Netherlands mainly consists of Betula pendula (Roth.), Pinus sylvestris (L.), Larix kaempferi (Carr.), and Pseudotsuga menziesii (Mirb. Franco). Even though these species are well known, the autogenic development of these species in an

  6. Who, What and How? Commentary on Cheney, F. N. (1963) the Teaching of Reference in American Library Schools. (Journal of Education for Librarianship, 3(3), 188-198)

    Science.gov (United States)

    Smith, Linda C.

    2015-01-01

    Cheney's paper was the first major article on the subject of teaching reference in American library schools. In the article, she addressed three questions: (1) Who is teaching reference?; (2) What is being taught?; and (3) How is it being taught? In this article, Linda Smith discusses how the teaching of reference has changed in the more than 50…

  7. « Gli Armeni e la spedizione persiana di Pietro il Grande (1722-23) ». Annali di Ca’ Foscari, 35/3, (1996), pp. 187-198.

    OpenAIRE

    Matthee, Rudi

    2010-01-01

    Armenian hopes that a Christian Crusade might liberate them from Muslim domination go back to the middle of the 16th century. This article discusses an important episode in the so-called Armenian liberation struggle, the campaign of Peter the Great against northern Iran in 1722-23. The author assesses the role of the well-know itinerant diplomat Israel Ory in the Armenian overtures toward various European courts, noting how the Armenians were ready to make common cause with the Russians, poss...

  8. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity ...

  9. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1995-12-01

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

  10. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    International Nuclear Information System (INIS)

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons

  11. Separation of 211At from irradiated bismuth target and labelling of a model protein

    International Nuclear Information System (INIS)

    Astatine-211 is a promising radionuclide for therapeutic use in nuclear medicine. An efficient method (70%) for radiochemical separation from the irradiated Bi-target has been described. The level of Bi contamination in the purified 2'11At-solution was estimated. Finally labelling of a model protein has been tried. (author). 14 refs

  12. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  13. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  14. Production cross section of At radionuclides from $^{7}$Li+$^{\\textrm{nat}}$Pb and $^{9}$Be+$^{\\textrm{nat}}$Tl reactions

    CERN Document Server

    Maiti, Moumita

    2011-01-01

    Earlier we reported theoretical studies on the probable production of astatine radionuclides from $^{6,7}$Li and $^{9}$Be-induced reactions on natural lead and thalliun targets, respectively. For the first time, in this report, production of astatine radionuclides has been investigated experimentally with two heavy ion induced reactions: $^{9}$Be+$^{\\textrm{nat}}$Tl and $^{7}$Li+$^{\\textrm{nat}}$Pb. Formation cross sections of the evaporation residues, $^{207,208,209,210}$At, produced in (HI, xn) channel, have been measured by the stacked-foil technique followed by the off-line $\\gamma$-spectrometry at the low incident energies ($<$50 MeV). Measured excitation functions have been explained in terms of compound nuclear reaction mechanism using Weisskopf-Ewing and Hauser-Feshbach model. Absolute cross section values are lower than the respective theoretical predictions.

  15. El controvertido desarrollo del deporte durante la transición democrática española (1975-1982. una aproximación a sus limitaciones y principales condicionantes = The controversial development of sport during the spanish democratic transition (1975-198

    Directory of Open Access Journals (Sweden)

    Sixte Abadía i Naudí

    2013-03-01

    Full Text Available Tras un periodo como el de la dictadura franquista (1939-1975, en el cual la actuación gubernamental en relación al fenómeno deportivo había sido, como mínimo, controvertida, la transición democrática (1975-1982 estableció un nuevo marco de actuación de los poderes públicos que posibilitaría, conjuntamente con la acción de los movimientos asociativos, la definitiva emergencia de un proceso de generalización del deporte entre la ciudadanía. Este desarrollo del deporte se contagió de la coyuntura social, política y económica característica de la transición democrática. De este modo, su evolución puede explicarse tanto a partir de los avances, acuerdos e iniciativas fruto de las políticas deportivas implementadas, como por la falta de consenso, críticas y limitaciones que constataron los movimientos asociativos y los medios de comunicación, y que explican una expansión no lineal del deporte español durante este periodo.--------------------------------------------------------------------------------After the period of Franco’s dictatorship (1939-1975, during which government action in relation to sports was to say controversial at least, democratic transition (1975-1982 established a new framework for the public authorities which allowed, in collaboration with the action of associations, the final appearance of a process of bringing sports to the masses. The development of sports was conditioned by the social, political and economical situation characteristic of the democratic transition. Thus, its evolution can be explained from the result of the sports policies implemented and from the lack of consensus, criticism and limitations found by associations and the media, and which explain a nonlinear and difficult sports development during this period.

  16. Laura Castellanos, México armado : 1943-1981, México, Ed Era, 2007 (Trad en français:  Le Mexique en armes. Guérilla et contre-insurrection 1943-198,  par Teresa Brisac, 2009)

    OpenAIRE

    Romero, Vicente,

    2010-01-01

    La prise de San Cristobal de las Casas en 1994 a été le choc qui servit d’impulsion à la journaliste mexicaine Laura Castellanos pour plonger dans les archives journalistiques afin de connaître quatre décennies d’histoire des groupes armés révolutionnaires au Mexique. Entre 1995 et 2002, une équipe de cinq personnes a consulté des sources hémérographiques et a effectué des entretiens avec les survivants de ces groupes armés et des personnes des secteurs sociaux qui leur étaient proches. La ré...

  17. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  18. Radiohalogenation of biomolecules. An experimental study on radiohalogen preparation, precursor synthesis, radiolabeling and biodistribution

    International Nuclear Information System (INIS)

    Radiohalogens are widely used in nuclear medicine, both as tool for diagnostic in vivo imaging, and in radionuclide therapy. This study deals with the use of radiohalogens; separation, precursor synthesis, labeling and biological behavior. The focus is on 211At and 124I, the former being a candidate for nuclide therapy and the latter potentially useful for diagnostic imaging and Auger-electron based radiotherapy. For astatine the separation, labeling and some biological behavior is described, and for iodine the latter two. Astatine was separated from an irradiated bismuth target by dry distillation. A novel cryotrap was developed for the isolation of astatine and subsequent synthesis of radiolabeled compounds. 5-[211At]astato-2'-deoxyuridine (AUdR) and N-succinimidyl-4-[211At]astatobenzoate (SAB) were synthesized in 95% respectively 90% radiochemical yields. The former is incorporated into DNA of proliferating cells and can therefore be used as an endoradiotherapeutic agent. The latter is a conjugate for the astatination of proteins. Human epidermal growth factor (hEGF) was tagged with astatine using three approaches: a) direct labeling of native hEGF, b) conjugation with SAB, and c) direct labeling of an hEGF - 7-(3-aminopropyl)-7,8-dicarba-nido-undecaborate(1-) conjugate. The overall labeling yields were 3.5% for direct labeling, 44% for SAB and 70% for the hEGF-nido-carborane conjugate. A new route to N-succinimidyl 3- and 4- [124I]iodobenzoate, two reagents for radioiodination of proteins is described affording 90% radiochemical yield. Three radioiodinated analogs of PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxyam ide, a peripheral-type benzodiazepine receptor antagonist, were synthesized. All three analogs were obtained in >90% radiochemical yield. Synthesis and application of 5-[124I]iodo-2'-deoxyuridine (IUdR) is presented. The closo-dodecaborate anion was evaluated as prosthetic group for radioiodination of macromolecules

  19. Un cas d’infection à Dracunculoidea en Polynésie française

    Czech Academy of Sciences Publication Activity Database

    Bercion, R.; Heaulme, M.; Viant, E.; Moravec, František; Bain, O.

    2010-01-01

    Roč. 70, č. 2 (2010), s. 198-198. ISSN 0025-682X Institutional research plan: CEZ:AV0Z60220518 Keywords : Dracunculoidea * acute arthritis * French Polynesia Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine

  20. AcEST: DK961354 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ), Positives = 27/65 (41%), Gaps = 4/65 (6%) Frame = -3 Query: 198 SSGGGSNQQLVKN*VLMRGVQRCSP----IIVQEEATINGR...: 198 SSGGGSNQQLVKN*VLMRGVQRCSP----IIVQEEATINGRSDSMGGVMGCEDRGV 43 S GGGS V Q P ++

  1. 211At production and recovery: first results of a new start

    International Nuclear Information System (INIS)

    Full text: 211At is the only alpha-emitting isotope which can be introduced into organic molecular structures by covalent chemical binding and possesses superior decay characteristics for therapeutic applications when compared with other alpha emitters. However, its production requires a minimum of 27,5 MeV alpha-particles, which are relatively rarely available. In view of the revival of alpha-therapy approaches a production of 211At has been set up at the MHH cyclotron (MC-35). The first aim of this project was to establish a target- and work-up-system for the reliable production of several ten MBq-quantities of 211At for animal- and cell-research. An aluminum-target-system holds a 1.3 cm diameter Bi-disc of 0.25 mm thickness. The disk is pressed onto a the aluminum backing with 2 tons/cm2. The front is covered with a 125 μm Al foil, cooled by a He jet which is separated from the vacuum by a 250 μm Ti foil. Starting with 27.5 MeV alpha-particles the resulting target-energy is 25 MeV. This relatively low energy is chosen to avoid any contamination with 210At and 210Po in the first experimental period. A beam current of 10 μA for 15 min (9 mCoulomb) yields 16.4 MBq 211At theoretically. Astatine is recovered from the target by a dry distillation technique, using various gases as a transport support-medium. The small all-quartz distillation-apparatus is heated up to 900 oC. Astatine is recovered in a small cool able vessel containing various trapping media. Distillation and trapping can be monitored with small radioactivity monitors. The whole system fits in a cubical 0.5 m glove box. Continuous monitoring of the distillation process allowed to optimize the heating rate, the transport support-medium and its flow-rate. Various trapping solutions were tested for their efficiency. Different beam dispersion in the target seems to influence the release and distillation of astatine from the molten bismuth-target. Two different release patterns were observed. The first

  2. 30 CFR 250.1002 - Design requirements for DOI pipelines.

    Science.gov (United States)

    2010-07-01

    ... 30 CFR 250.198) where— P=Internal design pressure in pounds per square inch (psi). S=Specified..., API Spec 6A, or the equivalent (incorporated by reference as specified in 30 CFR 250.198). Each flange... Spec 17J, incorporated by reference as specified in 30 CFR 250.198. (5) You must design pipeline...

  3. Establishment of a trimodality analytical platform for tracing, imaging and quantification of gold nanoparticles in animals by radiotracer techniques.

    Science.gov (United States)

    Chen, Chien-Hung; Lin, Fong-Sian; Liao, Wei-Neng; Liang, Sanching L; Chen, Min-Hua; Chen, Yo-Wen; Lin, Wan-Yu; Hsu, Ming-Hua; Wang, Mei-Ya; Peir, Jinn-Jer; Chou, Fong-In; Chen, Ching-Ya; Chen, Sih-Yu; Huang, Su-Chin; Yang, Mo-Hsiung; Hueng, Dueng-Yuan; Hwu, Yeukuang; Yang, Chung-Shi; Chen, Jen-Kun

    2015-01-01

    This study aims to establish a (198)Au-radiotracer technique for in vivo tracing, rapid quantification, and ex vivo visualization of PEGylated gold nanoparticles (GNPs) in animals, organs and tissue dissections. The advantages of GNPs lie in its superior optical property, biocompatibility and versatile conjugation chemistry, which are promising to develop diagnostic probes and drug delivery systems. (198)Au is used as a radiotracer because it simultaneously emits beta and gamma radiations with proper energy and half-life; therefore, (198)Au can be used for bioanalytical purposes. The (198)Au-tagged radioactive gold nanoparticles ((198)Au-GNPs) were prepared simply by irradiating the GNPs in a nuclear reactor through the (197)Au(n,γ)(198)Au reaction and subsequently the (198)Au-GNPs were subjected to surface modification with polyethylene glycol to form PEGylated (198)Au-GNPs. The (198)Au-GNPs retained physicochemical properties that were the same as those of GNP before neutron irradiation. Pharmacokinetic and biodisposition studies were performed by intravenously injecting three types of (198)Au-GNPs with or without PEGylation into mice; the γ radiation in blood specimens and dissected organs was then measured. The (198)Au-radiotracer technique enables rapid quantification freed from tedious sample preparation and shows more than 95% recovery of injected GNPs. Clinical gamma scintigraphy was proved feasible to explore spatial- and temporal-resolved biodisposition of (198)Au-GNPs in living animals. Moreover, autoradiography, which recorded beta particles from (198)Au, enabled visualizing the heterogeneous biodisposition of (198)Au-GNPs in different microenvironments and tissues. In this study, the (198)Au-radiotracer technique facilitated creating a trimodality analytical platform for tracing, quantifying and imaging GNPs in animals. PMID:25424326

  4. Report on the behalf of the Commission for Foreign Affairs, Defence and Armed Forces on the bill project authorizing the ratification of the association agreement between the European Union and the European Atomic Energy Community and their member States, on the one hand, and the Republic of Moldova, on the other hand (accelerated procedure) - Nr 283. Bill project - Nr 198. Law nr 2015-472 of the 27 April 2015

    International Nuclear Information System (INIS)

    In its first part, this report presents Moldova as a State marked by the influence of powerful neighbours: a young State marked by a conflict since its birth, a Moldovan identity with several minorities, a fragile economy. It describes the rapprochement process with the European Union (within the frame of a re-balancing of East-West relationships, and with a confirmed European orientation). It outlines the privileged relationships with France (France is one of the main investors). The second part discusses the association agreement as a new chapter of the relationships between the EU and Moldova. This agreement is presented as a result of a long rapprochement process, and is discussed as an agreement of political association and economic integration including cooperation aspects and deep and comprehensive free trade, and also as a strengthened framework for dialogue. The expected effects for the EU as well as for Moldova are reviewed. A sheet of data and facts and maps are provided in appendix. The rest of this huge document reports the Commission's discussion, the motivations for this agreement, the report of the impact study, the large text of the agreement, and the text of the bill project authorizing the ratification of the agreement

  5. Inclusive measurement of (p,πsup(-)xn) double charge exchange reactions on bismuth from threshold to 800 MeV

    International Nuclear Information System (INIS)

    The energy dependence of the total angle-integrated cross section for the production of astatine isotopes from (p,πsup(-)xn) double charge exchange reactions on bismuth (sup(209)Bi) was measured from 120 to 800 MeV using activation and radiochemical techniques. Chemical yields were estimated by direct radioassaying of sup(211)At activity in thin (approximately 1 mg/cmsup(2)), irradiated bismuth targets. Calculations of the contributions of secondary (2-step) reactions to these measured astatine yields were performed, based partially upon the observed sup(211)At activity although even at the highest energies, the contribution to products lighter than sup(207)At was negligible. These data for products with as many as 7 neutrons removed from the doubly coherent product (sup(210)At) display nearby gaussian shapes for the mass distributions of the astatine residues with the maximum occurring for about sup(204)At. The most probable momentum transfer deduced from these distributions for the initial πsup(-) production step was 335 MeV/c. The observed excitation functions display a behaviour similar to that observed for the yield of sup(210)Po from a (p,πsup(O)) reaction on sup(209)Bi, but radically different from that observed for inclusive πsup(-) reactions on a heavy nucleus. These data are discussed in terms of recent theoretical approaches to negative pion production from bismuth. In addition, a simple, schematic model is developed to treat the rapidly decreasing percentage of the total inclusive πsup(-) emission which is observed for this double charge exchange reaction. This model reflects the capacity of a nucleus to a source of internal energetic protons

  6. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    OpenAIRE

    BAYRAM, Ali

    1998-01-01

    In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 1...

  7. Human radiation studies: Remembering the early years: Oral history of Dr. Patricia Wallace Durbin, Ph.D., conducted November 11, 1994

    International Nuclear Information System (INIS)

    This report is a transcript of an interview of Dr. Patricia Wallace Durbin by representatives of the US DOE Office of Human Radiation Research. Dr. Durbin was selected for this interview because of her knowledge of the human plutonium injections and her recollections of key figures, especially Joseph Hamilton. After a brief biographical sketch Dr. Durbin discusses her loss of research funding from DOE, her recollections concerning research into strontium metabolism as part of Project Sunshine, her recollections relating to the rationale for studies of human metabolism of radionuclides, her remembrances of Dr. Hamilton's Astatine and Plutonium research, and her experiences in gathering archival records concerning these researches

  8. Drug: D04357 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D04357 Drug Gold Au 198 (USAN); Aurcoloid-198 (TN) Au 197.9682 196.9666 D04357.gif Antineoplasti ... er imaging]; Radioactive agent ATC code: V10AX06 Anatom ical Therapeutic Chemical (ATC) classification [BR: ... ld Au 198 (USAN) CAS: 10043-49-9 PubChem: 47206263 ATOM ... 1 1 Z Au 14.1400 -16.4500 BOND 0 InChI=1S/Au/i1+1 ...

  9. Dicty_cDB: Contig-U14832-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available bits (102), Expect = 2e-52 Identities = 190/198 (95%) Strand = Plus / Plus Query: 11 tcattttagncaacgttatccna...||||||||||||||||||||| Sbjct: 11 tcattttagncaacgttatccnaatttaaaaatgggnncatataaaganacnaattatgg 70 Query: 71 nt...102), Expect = 2e-52 Identities = 166/198 (83%) Strand = Plus / Plus Query: 11 tcattttagncaacgttatccnaatttaa...180 (93%) Strand = Plus / Plus Query: 29 tccnaatttaaaaatgggnncatataaaganacnaattat...ggnttggcnattgatttact 88 |||||||||||||||||||||||||||| ||||||||||||||||||||| ||||||| | Sbjct: 11 tccnaatttaaaa

  10. Drug: D10508 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10508 Drug Mebicar C8H14N4O2 198.1117 198.2224 D10508.gif ATC code: N06BX21 Anatomical Therapeu ... OANALEPTICS N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD ... AND NOOTROPICS N06BX Other psychostimulants and no ...

  11. Radiation exposure of the liver in intrathecal radiogold therapy

    International Nuclear Information System (INIS)

    18 patients suffering from leukemias or non-Hodgkin's lymphomas received intrathecally 198Au microcolloid for meningitis prophylaxis. According to the reported literature the estimated radiation dose of the liver is not be expected to have a decisive influence on the hepatic function. The application of 198Au colloid in the above mentioned cases can be recommended

  12. 75 FR 64771 - Self-Regulatory Organizations; Order Approving Minor Rule Violation Plan for BATS Y-Exchange, Inc.

    Science.gov (United States)

    2010-10-20

    .... 62924 (September 16, 2010), 75 FR 58011. The notice was published under File No. 10-198 used for BATS Y... FR 51295 (August 19, 2010) (File No. 10-198). In the approval order, the Commission noted that BATS Y... minor disciplinary infractions. See Securities Exchange Act Release No. 21013 (June 1, 1984), 49...

  13. 30 CFR 250.901 - What industry standards must your platform meet?

    Science.gov (United States)

    2010-07-01

    ... the Gulf of Mexico, (incorporated by reference as specified in § 250.198); (7) API Recommend Practice... Design (incorporated by reference as specified in § 250.198); (8) API RP 2FPS, Recommended Practice for...); (11) API RP 2SK, Recommended Practice for Design and Analysis of Station Keeping Systems for...

  14. 30 CFR 250.1629 - Additional production and fuel gas system requirements.

    Science.gov (United States)

    2010-07-01

    ... systems must conform to subsection 5.2, Fire Water Systems, of API RP 14G, Recommended Practice for Fire... as specified in 30 CFR 250.198). Pressure and fired vessels must have maintenance inspection, rating.../ASME Boiler and Pressure Vessel Code (incorporated by reference as specified in 30 CFR 250.198)....

  15. 30 CFR 250.1203 - Gas measurement.

    Science.gov (United States)

    2010-07-01

    ... CFR 250.198. (3) Ensure that the measurement components demonstrate consistent levels of accuracy... recorder is used, you must follow the recommendations in API MPMS as referenced in 30 CFR 250.198. (5) Take.... 1713 and 30 CFR part 212. (5) Upon the request of the Regional Supervisor, you must provide copies...

  16. Dicty_cDB: Contig-U07069-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ase; EC=3.6... 40 0.064 CU694389_26( CU694389 |pid:none) Ralstonia solanacearum strain Mol... 40 0.064 (A1AX...tntaaaaagaaaactgctgttggaaaatggcaatt 137 Query: 138 tccncaaggtggagtagaagttnaaaanaatnaagattattatgtagcagnacaaana...atnaagattattatgtagcagnacaaanaga 197 Query: 198 gattaaagaggaagttggattagagccatca...attganacattaaaanacgtttcaaagct 257 |||||||||||||||||||||||||||||||||||||||||||||||||||||...||||||| Sbjct: 198 gattaaagaggaagttggattagagccatcaattganacattaaaanacgtttcaaagct 257 Query: 258 tcaaaanccattatcttacatttatgaagattcncca

  17. Home Health Care and Discharged Hospice Care Patients: United States, 2000 and 2007

    Science.gov (United States)

    ... 239) Malignant neoplasm . . . . . . . . . . . . . . .(140–208,230–234) Endocrine, nutritional, and metabolic diseases and immunity disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . .(240–279) Diabetes mellitus. . . . . . . . . . . . . . . . . . . . . . . . . .(250) ... 198.7,198.82–199,230–234) Endocrine, nutritional, and metabolic diseases and immunity disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .(240–279) Diabetes mellitus. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .(250) ...

  18. Distribution of butyltins in waters and sediments of the Mandovi and Zuari estuaries, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Garg, A.; Meena, R.M.; Bhosle, N.B.

    dealkylation by UV photolysis and microbial degradation, and takes place in following steps, TBT g198 DBT g198 MBT and inorganic tin. For assessing the degradation of TBT, a degradation index for BT was calculated based on the following equation (Díez et al...

  19. Drug: D00337 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00337 Drug Guaifenesin (JP16/USP/INN); Hustosil (TN); Robitussin (TN) C10H14O4 198.0892 198.215 ... assification [BR:br08303] R RESPIRATORY SYSTEM R05 COUGH ... AND COLD PREPARATIONS R05C EXPECTORANTS, EXCL. COM ... BINATIONS WITH COUGH ... SUPPRESSANTS R05CA Expectorants R05CA03 Guaifenesi ...

  20. Transgenní miniprasata pro Huntingtonovu nemoc

    Czech Academy of Sciences Publication Activity Database

    Hodanová, J.; Juhásová, Jana; Valeková, Ivona; Rausová, Petra; Jozefovičová, M.; Juhás, Štefan

    2015-01-01

    Roč. 198, č. 3 (2015), s. 198-205. ISSN 0506-8231 R&D Projects: GA MŠk ED2.1.00/03.0124; GA MŠk(CZ) 7F14308; GA TA ČR(CZ) TA01011466 Institutional support: RVO:67985904 Keywords : Huntington´s disease Subject RIV: EB - Genetics ; Molecular Biology

  1. Drug: D10438 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D10438 Drug Guselkumab (USAN) C6402H9864N1676O1994S42 143471.0249 143559.5844 (Heavy chain) EVQL ... -L90, L139-L198, L'22-L'90, L'139-L'198) (modified residues : L1, L'1 Q=pyroglutamic acid [CPD:C01879]) (glycos ...

  2. Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo

    Directory of Open Access Journals (Sweden)

    Won-Kyung Cho

    2012-01-01

    Full Text Available Porcine epidemic diarrhea virus (PEDV causes diarrhea of pigs age-independently and death of young piglets, resulting in economic loss of porcine industry. We have screened 333 natural oriental herbal medicines to search for new antiviral candidates against PEDV. We found that two herbal extracts, KIOM 198 and KIOM 124, contain significant anti-PED viral effect. KIOM 198 and KIOM 124 were identified as Epimedium koreanum Nakai and Lonicera japonica Thunberg, respectively. The further plaque and CPE inhibition assay in vitro showed that KIOM 198 has much stronger antiviral activity than KIOM 124. Additionally, KIOM 198 exhibited a similar extent of antiviral effect against other subtypes of Corona virus such as sm98 and TGE viruses. Cytotoxicity results showed that KIOM 198 is nontoxic on the cells and suggest that it can be delivered safely for therapy. Furthermore, when we orally administered KIOM 198 to piglets and then infected them with PEDV, the piglets did not show any disease symptoms like diarrhea and biopsy results showed clean intestine, whereas control pigs without KIOM 198 treatment exhibited PED-related severe symptoms. These results imply that KIOM 198 contains strong antiviral activity and has a potential to be developed as an antiviral phytomedicine to treat PEDV-related diseases in pigs.

  3. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    Directory of Open Access Journals (Sweden)

    Ali BAYRAM

    1998-03-01

    Full Text Available In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 10, 50 and 259 mm/min. Strength properties of dual-phase steels were investigated depending on annealing temperature, ratio of martensite and loading rate.

  4. A route for polonium 210 production from alpha-particle irradiated bismuth-209 target

    International Nuclear Information System (INIS)

    A method is proposed for production of polonium-210 via the 209Bi(α,3n)210 At nuclear reaction. Bombardment of a bismuth-209 target was performed with a 37 MeV alpha-particle beam that leads to the production of astatine-210 (T1/2 = 8.1 h), which decays to polonium-210. It is purified from the bismuth target matrix by employing liquid-liquid extraction using tributyl phosphate (TBP) in para-xylene from 7 M hydrochloric acid. Back extraction of polonium-210 was performed by 9 M nitric acid. This method allows to purify a tracer amount of Po-210 (2.6 x 10-13 mol) from macroscopic amount of Bi (2.8 x 10-2 mol).

  5. Effective bond orders from two-step spin–orbit coupling approaches: The I{sub 2}, At{sub 2}, IO{sup +}, and AtO{sup +} case studies

    Energy Technology Data Exchange (ETDEWEB)

    Maurice, Rémi, E-mail: remi.maurice@subatech.in2p3.fr; Montavon, Gilles [SUBATECH, CNRS UMR 6457, IN2P3/EMN Nantes/Université de Nantes, 4 rue Alfred Kastler, BP 20722, 44307 Nantes Cedex 3 (France); Réal, Florent; Gomes, André Severo Pereira; Vallet, Valérie [Laboratoire PhLAM, CNRS UMR 8523, Université de Lille, 59655 Villeneuve d’Ascq Cedex (France); Galland, Nicolas [CEISAM, UMR CNRS 6230, Université de Nantes, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3 (France)

    2015-03-07

    The nature of chemical bonds in heavy main-group diatomics is discussed from the viewpoint of effective bond orders, which are computed from spin–orbit wave functions resulting from spin–orbit configuration interaction calculations. The reliability of the relativistic correlated wave functions obtained in such two-step spin–orbit coupling frameworks is assessed by benchmark studies of the spectroscopic constants with respect to either experimental data, or state-of-the-art fully relativistic correlated calculations. The I{sub 2}, At{sub 2}, IO{sup +}, and AtO{sup +} species are considered, and differences and similarities between the astatine and iodine elements are highlighted. In particular, we demonstrate that spin–orbit coupling weakens the covalent character of the bond in At{sub 2} even more than electron correlation, making the consideration of spin–orbit coupling compulsory for discussing chemical bonding in heavy (6p) main group element systems.

  6. Effective bond orders from two-step spin–orbit coupling approaches: The I2, At2, IO+, and AtO+ case studies

    International Nuclear Information System (INIS)

    The nature of chemical bonds in heavy main-group diatomics is discussed from the viewpoint of effective bond orders, which are computed from spin–orbit wave functions resulting from spin–orbit configuration interaction calculations. The reliability of the relativistic correlated wave functions obtained in such two-step spin–orbit coupling frameworks is assessed by benchmark studies of the spectroscopic constants with respect to either experimental data, or state-of-the-art fully relativistic correlated calculations. The I2, At2, IO+, and AtO+ species are considered, and differences and similarities between the astatine and iodine elements are highlighted. In particular, we demonstrate that spin–orbit coupling weakens the covalent character of the bond in At2 even more than electron correlation, making the consideration of spin–orbit coupling compulsory for discussing chemical bonding in heavy (6p) main group element systems

  7. Different ways to improve the clinical effectiveness of radioimmunotherapy in solid tumors

    Directory of Open Access Journals (Sweden)

    Chatal Jean-Francois

    2009-09-01

    Full Text Available Radioimmunotherapy (RIT has been proven effective in the treatment of radiosensitive non-Hodgkin lymphoma but, for radioresistant solid tumors, new approaches are necessary to improve the clinical effectiveness. A real improvement has been the introduction of the pretargeting technology which appeared to be able to significantly increase tumor-to-normal organ uptake ratios.Another very promising approach consists in associating RIT with other treatment modalities. Finally the use of alpha particle-emitting radionuclides such as astatin-211 or bismuth-213 (alpha-RIT should allow to efficiently eradicate disseminated microscopic clusters of tumor cells or isolated tumor cells which fit well with the short path length of alpha particles.

  8. Sequential radioimmunotherapy with 177Lu- and 211At-labeled monoclonal antibody BR96 in a syngeneic rat colon carcinoma model

    DEFF Research Database (Denmark)

    Eriksson, Sophie E; Elgström, Erika; Bäck, Tom;

    2014-01-01

    UNLABELLED: Alpha-particle emitters, such as astatine-211 (211At), are generally considered suitable for the treatment of small cell clusters due to their short path length, while beta-particle emitters, for example, Lutetium-177 (177Lu), have a longer path length and are considered better for...... small, established tumors. A combination of such radionuclides may be successful in regimens of radioimmunotherapy. In this study, rats were treated by sequential administration of first a 177Lu-labeled antibody, followed by a 211At-labeled antibody 25 days later. METHODS: Rats bearing solid colon...... carcinoma tumors were treated with 400 MBq/kg body weight 177Lu-BR96. After 25 days, three groups of animals were given either 5 or 10 MBq/kg body weight of 211At-BR96 simultaneously with or without a blocking agent reducing halogen uptake in normal tissues. Control animals were not given any 211At-BR96...

  9. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

    2013-01-01

    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  10. Development of 211At Chemistry for Labelling Biomolecules

    International Nuclear Information System (INIS)

    Our studies have demonstrated that high recovery of 211At can be obtained using a “wet chemistry” approach to isolation from the bismuth target. We have also demonstrated that direct labelling of antibody-B10 conjugates with 211At can be performed in high yields, and that the astatinated antibodies are stable to in vivo deastatination. While these results will allow us to enter clinical studies with 211At-labelled antibodies, the chemistry associated with 211At is not fully understood. Therefore, it is important that many more basic studies to be conducted with 211At, so the optimal labelling reagent for each type of disease-targeting agent becomes apparent

  11. Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status

    DEFF Research Database (Denmark)

    Lyckesvärd, Madeleine Nordén; Delle, Ulla; Kahu, Helena;

    2014-01-01

    Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ((211)At), concentrated in the thyroid by the same...... levels of γH2AX decreased during the first 24h in both cycling and stationary cultures and complete repair was seen in all cultures but cycling cells exposed to (211)At. Compared to stationary cells alpha particles were more harmful for cycling cultures, an effect also seen at the pChk2 levels...... cultures at a modest level of damage, clearly demonstrating that cell cycle status influences the relative effectiveness of alpha particles....

  12. An improved synthesis of an 125I and 211At labelled benzamide for melanoma imaging

    International Nuclear Information System (INIS)

    Recent studies have indicated that benzamides can exhibit affinity for malignant melanoma and may be exploited diagnostically in the treatment of this cancer. Radioiodinated N-(2-diethylaminoethyl)-3-[123I/131I]iodo-4-methoxybenzamide (*I-IMBA) is a benzamide with promising diagnostic properties. A new synthesis procedure was developed to obtain 125I-IMBA suitable for use in vivo. The assets of the procedure include the use of less toxic reagents and better reproducible results when radiolabelling the precursor. The procedure also facilitates the synthesis of the astatinated N-(2-diethylaminoethyl)-3-[211At]astatine-4-methoxybenzamide (211At-AMBA), a new benzamide with a therapeutic potential. The regiospecific no-carrier-added 125I- and 211At-labeling of the benzamide is performed by demetalation of an organotin precursor. Using tributylstannyl as a leaving group, the radiochemical yield obtained after 15 minutes of reaction was 70 %-90 % for both 125I-IMBA and 211At-AMBA. The labelling was performed in a solution of MeOH:AcOH with NCS as the oxidising agent. The organotin precursor N-(2-diethylaminoethyl)-3-(tri-n-butylstannyl)-4-methoxy-benzamide was synthesized from 3-bromo-4-methoxybenzoic acid, with n-BuLi (2 eq) and Bu3SnCl (1 eq) in THF, giving 3-(tri-n-butylstannyl)-4-methoxybenzoic acid. The amide function was introduced by converting the acid group into an active N-succinimidyl-ester, a good leaving group in the reaction with 2-(diethylamino)ethylamine. The overall yield of the organotin precursor was 65 %

  13. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: bruce.marsh@cern.ch [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others

    2013-12-15

    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  14. Radiation investigations to assess of the results of radiosynoviorthesis of the knee joints in patients with rheumatoid arthritis

    International Nuclear Information System (INIS)

    Fifty-two patients with rheumatoid arthritis were examined, to whom colloid solution of gold-198 was injected with therapeutic purposes in 100 knee joints. Clinical and laboratory studies, roentgenography, sonography, arthropneumography, scintigraphy using 113mIn-DTPA, and radionuclide scanning of the joints after injection of gold-198 were carried out before and a year after radiosynoviorthesis of the knee joints The findings indicate a high efficacy of comprehensive examinations of the knee joints in patients with rheumatoid arthritis in the course of therapy with colloid gold-198. 6 refs., 5 tabs

  15. [Jörg Driesner, Robert Riemen. Spiegel und Bilder in den Nachlassinventaren deutscher Kaufleute in Reval im 18. Jahrhundert] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2006-01-01

    Arvustus: Jörg Driesner u. Robert Riemen. Spiegel und Bilder in den Nachlassinventaren deutscher Kaufleute in Reval im 18. Jahrhundert. In: Land und Meer. Köln, Weimar, Wien: Böhlau 2004. S. 165-198.

  16. Glutelin protein fraction as a tool for clear identification of Amaranth accessions

    Czech Academy of Sciences Publication Activity Database

    Džunková, M.; Janovská, D.; Hlásná, P.; Čepková, J.; Prohasková, A.; Kolář, Michal

    2011-01-01

    Roč. 53, - (2011), s. 198-205. ISSN 0733-5210 Institutional research plan: CEZ:AV0Z50520514 Keywords : amaranth * glutelin * accession Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.073, year: 2011

  17. Kunstivaldkonna tähtsus : seos avalike eesmärkidega / Alberta Arthurs, Frank Hodsoll ; tõlk. Johanna Ross

    Index Scriptorium Estoniae

    Arthurs, Alberta

    2008-01-01

    Originaali pealkiri: The importance of the arts sector : how it relates to the public purpose // The Journal of Arts Management, Law and Society. Vol. 28, nr. 2, lk. 102-108. Lühidalt autoritest lk. 198

  18. Eesti inimsõbralikuks e-riigiks / Hannes Astok

    Index Scriptorium Estoniae

    Astok, Hannes, 1964-

    2007-01-01

    USA Browni ülikooli uuringu järgi on Eesti langenud oma e-riigiga 128. kohale 198 riigi seas. Eesti riiklike veebilehtede info ja internetisaitidel pakutavate teenuste keerukast leidmisest. Kommenteerivad: Henrik Roonemaa, Ivar Tallo

  19. Bifunctional chelates of RH-105 and AU199 as potential radiotherapeutic agents

    Energy Technology Data Exchange (ETDEWEB)

    Droege, P.

    1997-03-01

    Research is presented on new bifunctional chelating ligand systems with stability on the macroscopic and radiochemical levels. The synthesis of the following complexes are described: rhodium 105, palladium 109, and gold 198.

  20. Dicty_cDB: Contig-U14071-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available protein; AltName: Full=Ct-Ras; F... 203 6e-51 CU928180_381( CU928180 |pid:none) Kluyveromyces thermotoler...198 2e-49 CU928168_367( CU928168 |pid:none) Kluyveromyces thermotolerans str... 1...98 2e-49 AY891660_1( AY891660 |pid:none) Synthetic construct Homo sapiens c... 198 2e-49 CR382123_579( CR382123 |pid:none) Kluyver.... 167 7e-40 BC018060_1( BC018060 |pid:none) Homo sapiens Ras-like without CAAX......-49 AF329890_1( AF329890 |pid:none) Pisolithus sp. 441 ras-like protei... 198 3e-49 DQ078265_1( DQ078265 |pi

  1. Excited-state dynamics of furan studied by sub-20-fs time-resolved photoelectron imaging using 159-nm pulses

    International Nuclear Information System (INIS)

    The excited-state dynamics of furan were studied by time-resolved photoelectron imaging using a sub-20-fs deep UV (198 nm) and vacuum UV (159 nm) light source. The 198- and 159-nm pulses produce photoionization signals in both pump-probe and probe-pump pulse sequences. When the 198-nm pulse precedes the 159-nm pulse, it creates the 1A2(3s) Rydberg and 1B2(ππ∗) valence states, and the former decays exponentially with a time constant of about 20 fs whereas the latter exhibits more complex wave-packet dynamics. When the 159-nm pulse precedes the 198-nm pulse, a wave packet is created on the 1A1(ππ∗) valence state, which rapidly disappears from the observation window owing to structural deformation. The 159-nm photoexcitation also creates the 3s and 3px,y Rydberg states non-adiabatically

  2. Sociální poznávání

    Czech Academy of Sciences Publication Activity Database

    Baumgartner, František

    Praha: Grada Publishing, 2008, s. 181-198 ISBN 978-80-247-1428-8 Institutional research plan: CEZ:AV0Z70250504 Keywords : social cognition * interpersonal perception * attribution Subject RIV: AN - Psychology

  3. Alcohol Use and Binge Drinking Among Women of Childbearing Age: United States, 2011-2013

    Science.gov (United States)

    ... and Mortality Weekly Report ( MMWR ) MMWR Share Compartir Alcohol Use and Binge Drinking Among Women of Childbearing ... 44 years (N = 198,098) who reported any alcohol use or binge drinking, † by selected characteristics — Behavioral ...

  4. Tectonic movements detected recently in the Upper Rhine Graben

    Czech Academy of Sciences Publication Activity Database

    Stemberk, Josef; Fecker, E.; Košťák, Blahoslav; Rybář, Jan

    2008-01-01

    Roč. 170, č. 1 (2008), s. 187-198. ISSN 0453-3267 Institutional research plan: CEZ:AV0Z30460519 Keywords : tectonic movements * monitoring * Upper Rhine Graben Subject RIV: DB - Geology ; Mineralogy

  5. Mezinárodní folklorní festival Strážnice

    Czech Academy of Sciences Publication Activity Database

    Stavělová, Daniela

    Praha : Divadelní ústav, 2001, s. 198-199. ISBN 80-7008-112-0 Institutional research plan: CEZ:AV0Z9058907 Keywords : festival, stage production, folklore Subject RIV: AC - Archeology, Anthropology, Ethnology

  6. Nástin rozšíření vybraných ruderálních a synantropních druhů plžů (Gastropoda) v oblasti Šumavy a Pošumaví

    Czech Academy of Sciences Publication Activity Database

    Dvořák, L.; Hlaváč, Jaroslav

    2001-01-01

    Roč. 6, - (2001), s. 183-198. ISSN 1211-7420 Institutional research plan: CEZ:AV0Z3013912 Keywords : distribution * new records * ruderal and synanthropic habitats Subject RIV: DB - Geology ; Mineralogy

  7. Reference: PROLAMINBOX [PLACE

    Lifescience Database Archive (English)

    Full Text Available PROLAMINBOX Brown JWS, Wandelt C, Feix G The upstream regions of zein genes: sequence analysis a ... nd expression in the unicellular green ... alga Acetabularia. Eur J Cell Biol 42:161-170 (198 ...

  8. Skryto za vlnou vítězství. Devadesátá léta

    Czech Academy of Sciences Publication Activity Database

    Gjuričová, Adéla

    Praha : DOX, Centre for Contemporary Art, 2014 - (Anděl, J.), s. 195-198 ISBN 978-80-87446-30-0 Institutional support: RVO:68378114 Keywords : development after 1989 * globalization * East-Central Europe Subject RIV: AB - History

  9. Exploring branched Hamiltonians for a class of nonlinear systems

    Czech Academy of Sciences Publication Activity Database

    Bagchi, B.; Modak, S.; Panigrahi, P. K.; Růžička, František; Znojil, Miloslav

    2015-01-01

    Roč. 30, č. 39 (2015), s. 1550213. ISSN 0217-7323 Institutional support: RVO:61389005 Keywords : quantization * branched classical Hamiltonians * partner quantum Hamiltonians * perturbation solutions Subject RIV: BE - Theoretical Physics Impact factor: 1.198, year: 2014

  10. Nové velké laserové projekty Evropské unie v ČR

    Czech Academy of Sciences Publication Activity Database

    Rohlena, Karel

    2010-01-01

    Roč. 60, č. 4 (2010), 197-198. ISSN 0009-0700 Institutional research plan: CEZ:AV0Z10100523 Keywords : diode pumped solid state lasers * repetative regime * high average power Subject RIV: BH - Optics, Masers, Lasers

  11. Annual report 1986 Interfacultary Reactor Institute

    International Nuclear Information System (INIS)

    In this annual report of the Dutch Interfacultary Reactor Institute, summary- and detailed reports are presented of Current research during 198? of the departments radiochemistry, radiation chemistry, radiation physics, and reactor physics. (H.W.). refs.; figs.; tabs

  12. 杨梅叶水溶性提取物的抗氧化、抗菌活性与防腐应用

    Czech Academy of Sciences Publication Activity Database

    君酸, 杨.; 云酸, 朱.; 清酸, 吴.; 洁酸, 尹.; Langhansová, Lenka; Vaněk, Tomáš; 生酸, 高.

    2014-01-01

    Roč. 28, č. 2 (2014), s. 198-202. ISSN 1006-2513 Institutional support: RVO:61389030 Keywords : Myrica rubra leaf * antioxidation * antisepsis Subject RIV: EF - Botanics http://d.g.wanfangdata.com.cn/Periodical_zgsptjj201402029.aspx

  13. Formation of less-known structurally complex ζb and orthorhombic quasicrystalline approximant εn on solidification of selected Al–Pd–Cr alloys

    Czech Academy of Sciences Publication Activity Database

    Adamech, A.; Černičková, I.; Ďuriška, L.; Kolesár, V.; Drienovský, M.; Bednarčík, J.; Svoboda, Milan; Janovec, J.

    2014-01-01

    Roč. 97, NOV (2014), s. 189-198. ISSN 1044-5803 Institutional support: RVO:68081723 Keywords : complex metallic alloys * aluminium alloys * intermetallics Subject RIV: JG - Metallurgy Impact factor: 1.845, year: 2014

  14. Umělecké dílo ve veřejném prostoru

    Czech Academy of Sciences Publication Activity Database

    Kratochvíl, Petr

    Praha: Architectura + Galerie Jaroslava Fragnera, 2016 - (Pučerová, K.), s. 198-201 ISBN 978-80-88161-00-4 Institutional support: RVO:68378033 Keywords : architecture * public space * art Subject RIV: AL - Art, Architecture , Cultural Heritage

  15. Disk theatre

    Czech Academy of Sciences Publication Activity Database

    Svobodová, Markéta

    [Řevnice]: Arbor vitae, 2012 - (Švácha, R.), s. 198-201 ISBN 978-80-87164-87-7 Institutional support: RVO:68378033 Keywords : SIAL * architecture * Prague Subject RIV: AL - Art, Architecture, Cultural Heritage

  16. Haplotype Detection from Next-Generation Sequencing in High-Ploidy-Level Species: 45S rDNA Gene Copies in the Hexaploid Spartina maritima

    Czech Academy of Sciences Publication Activity Database

    Boutte, J.; Aliaga, B.; Lima, O.; de Carvalho, J.F.; Ainouche, A.; Macas, Jiří; Rousseau-Gueutin, M.; Coriton, O.; Ainouche, M.; Salmon, A.

    2016-01-01

    Roč. 6, č. 1 (2016), s. 29-40. ISSN 2160-1836 Institutional support: RVO:60077344 Keywords : poaceae * duplication * paralogy * bioinformatics * polyploidy Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.198, year: 2014

  17. Andalusi sherds from Prague

    Czech Academy of Sciences Publication Activity Database

    Charvát, Petr; Hrdlička, Ladislav; Delery, C.

    2013-01-01

    Roč. 65, č. 1 (2013), s. 198-206. ISSN 0323-1267 Institutional support: RVO:67985912 Keywords : Middle Ages * Prague * commerce * Spain * Almohad empire Subject RIV: AC - Archeology, Anthropology, Ethnology

  18. Čas Kouzelného vrchu

    Czech Academy of Sciences Publication Activity Database

    Dubský, Ivan

    -, č. 72 (2008), s. 87-198. ISSN 1210-2881 Institutional research plan: CEZ:AV0Z90090514 Keywords : Exploration * Magic Mountain * mystery * mystery of time * Thomas Mann Subject RIV: AA - Philosophy ; Religion

  19. English in the Czech Republic: Linguists’ perspectives

    Czech Academy of Sciences Publication Activity Database

    Kaderka, Petr; Prošek, Martin

    -, č. 28 (2014), s. 173-198. ISSN 0933-1883 Institutional support: RVO:68378092 Keywords : language situation * English as a global language * attitudes towards English * national language institution * sociolinguistics * Czech Republic Subject RIV: AI - Linguistics

  20. Is the motivation to become a teacher related to pre-service teachers' intentions to remain in the profession?

    NARCIS (Netherlands)

    Bruinsma, Marjon; Jansen, Ellen P. W. A.

    2010-01-01

    This study investigated 198 pre-service teachers' intrinsic and extrinsic motivation for becoming teachers and focused on the distinction between adaptive motives, which promote lasting and effective engagement, and maladaptive motives, which promote superficial engagement. We examined the relations

  1. Lactic acid test

    Science.gov (United States)

    ... test is most often done to diagnose lactic acidosis . Normal Results 4.5 to 19.8 mg/ ... PA: Elsevier Saunders; 2016:chap 118. Read More Acidosis Aerobic Anaerobic Heart failure - overview Hepatic Metabolism Muscle ...

  2. EST Table: BP178212 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BP178212 maV30818 10/09/28 44 %/198 aa ref|NP_001153726.1| glyoxylate reductase/hydroxypyruvate ... tase-like [Tribolium castaneum] gb|EFA08834.1| LOW QUALITY ... PROTEIN: hypothetical protein TcasGA2_TC006532 [Tr ... /09/10 44 %/198 aa gi|270012386|gb|EFA08834.1| LOW QUALITY ... PROTEIN: hypothetical protein TcasGA2_TC006532 [Tr ...

  3. Dicty_cDB: Contig-U09412-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ||||||||||||||| Sbjct: 283 tgatgttactttttgtggtccattcttannnnnnnnnntttaggtcgtgtattattaatt 342 Query: 343 gatcttgtaaatagtttagttgtaaaaata...dentities = 198/198 (100%) Strand = Plus / Plus Query: 1 attatcacaactattttataataaaccaattttaaagatta...(164), Expect = 5e-89 Identities = 194/194 (100%) Strand = Plus / Plus Query: 223 aggtgaaaacaatttatcatttaaaaaatggacattaggtaat...ttaaaaaatggacattaggtaattcagttgatagaataaa 282 Query: 283 tgatgttactttttgtggtccat...oarchaeum equitans Kin4-M, complete genome. 54 0.009 1 ( AF130844 ) Homo sapiens ZNF127AS gene, putative 3' untran

  4. Drug: D08857 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D08857 Drug Anrukinzumab (USAN) C6452H9954N1714O2024S46 145301.5817 145391.3306 (A chain) EVQLVE ... 138-C198, D23-D92, D138-D198) Peptide Treatment of asthma ... Monoclonal antibody IL-13 [HSA:3596] [KO:K05435] h ... 30(3596) Jak-STAT signaling pathway hsa05310(3596) Asthma ... Target-based classification of drugs [BR:br08310] ...

  5. The influence of a short-term tissue culture medium storage on the mechanical properties of composites based on glass fibers and polysiloxane

    Czech Academy of Sciences Publication Activity Database

    Balík, Karel; Sochor, M.; Hulejová, H.; Suchý, T.; Černý, Martin

    2007-01-01

    Roč. 51, č. 4 (2007), s. 198-201. ISSN 0862-5468 R&D Projects: GA ČR GA106/03/1167 Institutional research plan: CEZ:AV0Z30460519 Keywords : composite materials * glass fibers * polysiloxane Subject RIV: JI - Composite Materials Impact factor: 0.488, year: 2007 http://www.ceramics-silikaty.cz/2007/pdf/2007_04_198.pdf

  6. Low-dose-rate interstitial brachytherapy preserves good quality of life in buccal mucosa cancer patients

    International Nuclear Information System (INIS)

    The purpose of this study was to determine the results and long-term changes in radiation toxicity of stage I-II buccal mucosa cancer patients treated by low-dose-rate (LDR) brachytherapy with 198Au grains. A total of 133 stage I-II buccal mucosa carcinomas patients received 198Au grain implantation brachytherapy between January 1982 and July 2005: 75 of them were treated by 198Au grain implantation alone and 58 were treated by 198Au implantation in combination with external irradiation. The average 198Au-grain dose was 70 Gy in 7 days. Gross tumor areas ranged from 2.4 cm2 to 9 cm2, and the clinical target areas ranged from 6 cm2 to 15 cm2. The follow-up periods ranged from 3 months to 20 years (mean: 5 years 11 months and median: 5 years 1 months). Failure at the site of the primary lesion occurred in 17 patients. Post-treatment mucosal ulceration developed in 15 patients, and all were cured within 25 months by conservative treatment. Osteoradionecrosis was diagnosed in 8 patients, but only one patient required surgical treatment. No severe complications or aggravation of complications developed more than 10 years after treatment. The results of low-dose-rate (LDR)-brachytherapy (BT) alone and LDR-BT in combination with external irradiation at a total dose of 25 Gy were acceptable from the standpoint of cure rate and quality of life (QOL). (author)

  7. Experimental cross-sections for proton induced nuclear reactions on mercury up to 65 MeV

    Science.gov (United States)

    Hermanne, A.; Tárkányi, F.; Takács, S.; Ditrói, F.; Szücs, Z.; Brezovcsik, K.

    2016-07-01

    Cross-sections for formation of activation products induced by protons on natural mercury targets were measured. Results for 196m,196g,197g(cum), 198m,198g,199g(cum), 200g(cum), 201,202Tl, 194g(cum), 195g(cum), 196g(cum), 198m,199g(cum) Au and 195m,197m,203Hg are presented up to 65 MeV incident particle energy, many of these for the first time. The experimental data are compared with literature values and with the predictions of the TALYS 1.6 code (results taken from TENDL-2015 on-line library), thick target yields were derived and possible applications in biomedical sciences are discussed.

  8. New data on cross-sections of deuteron induced nuclear reactions on gold up to 50 MeV and comparison of production routes of medically relevant Au and Hg radioisotopes

    CERN Document Server

    Tárkányi, F; Ditrói, F; Takács, S; Adam-Rebeles, R

    2016-01-01

    Investigations of cross-sections of deuteron induced nuclear reactions on gold were extended up to 50 MeV by using the standard stacked foil irradiation technique and high resolution gamma-ray spectrometry. New cross-sections are reported for the $^{197}$Au(d,xn)$^{197m,197g,195m,195g,193m,193g}$Hg and $^{197}$Au(d,x)$^{198m,198g,196m,196g,195,194}$Au nuclear reactions. The application for production of the medically relevant isotopes $^{198}$Au and $^{195m,195g,197m,197g}$Hg is discussed, including the comparison with other charged particle induced production routes. The possible use of the $^{197}$Au(d,x)$^{197m,197g,195m,193m}$Hg and $^{196m,196g}$Au reactions for monitoring deuteron beam parameters is also investigated.

  9. An overview of the recent results on fission dynamics from the NAND facility

    Indian Academy of Sciences (India)

    B R Behera

    2015-08-01

    This paper summarizes the results of some of the recent fusion–fission experiments carried out at the National Array of Neutron Detectors (NAND) Phase-01 installed at the Pelletron+LINAC accelerator facility of Inter-University Accelerator Centre (IUAC), New Delhi. Pre-scission neutron multiplicity excitation functions are measured for the 213,215,217Fr, 210,212,214,216Rn and 206,210Po compound nuclei populated through the fusion of the 19F+194,196,198Pt, 16,18O+194,198Pt and 12C+194,198Pt systems, respectively. Pre-scission neutron yields from these reactions are compared with the extensive statistical model calculations to look for the effects due to the compound nucleus shell closure, / ratio of the compound nucleus, magnitude of the saddle-point shell corerction and fission time-scale.

  10. Evolution of fusion hindrance for asymmetric systems at deep sub barrier energies

    CERN Document Server

    Shrivastavaa, A; Pandit, S K; Nanal, V; Ichikawa, T; Hagino, K; Navin, A; Palshetkar, C S; Parkar, V V; Ramachandran, K; Rout, P C; Kumar, Abhinav; Chatterjee, A; Kailas, S

    2016-01-01

    Measurements of fusion cross-sections of 7Li and 12C with 198Pt at deep sub-barrier energies are reported to unravel the role of the entrance channel in the occurrence of fusion hindrance. The onset of fusion hindrance has been clearly observed in 12C + 198Pt system but not in 7Li + 198Pt system, within the measured energy range. Emergence of the hindrance, moving from lighter (6,7Li) to heavier (12C,16O) projectiles is explained employing a model that considers a gradual transition from a sudden to adiabatic regime at low energies. The model calculation reveals a weak effect of the damping of coupling to collective motion for the present systems as compared to that obtained for systems with heavier projectiles.

  11. M233I Mutation in the β-Tubulin of Botrytis cinerea Confers Resistance to Zoxamide.

    Science.gov (United States)

    Cai, Meng; Lin, Dong; Chen, Lei; Bi, Yang; Xiao, Lu; Liu, Xi-li

    2015-01-01

    Three phenotypes were detected in 161 Botrytis cinerea field isolates, including Zox(S)Car(S) (sensitive to zoxamide and carbendazim), Zox(S)Car(R) (sensitive to zoxamide and resistant to carbendazim), and Zox(R)Car(R) (resistant to zoxamide and carbendazim), but not Zox(R)Car(S) (resistant to zoxamide and sensitive to carbendazim). The baseline sensitivity to zoxamide was determined with a mean EC50 of 0.76 μg/ml. Two stable Zox(R)Car(S) isolates were obtained with a resistance factor of 13.28 and 20.43; there was a fitness penalty in mycelial growth rate, sporulation, virulence and sclerotium production. The results suggest that the resistance risk of B. cinerea to zoxamide is low where benzimidazoles have not been used. E198V, E198K and M233I, were detected in the β-tubulin of Zox(S)Car(R), Zox(R)Car(R), Zox(R)Car(S), respectively. Molecular docking indicated that position 198 in β-tubulin were targets for both zoxamide and carbendazim. The mutations at 198 prevented formation of hydrogen bonds between β-tubulin and carbendazim (E198V/K), and changed the conformation of the binding pocket of zoxamide (E198K). M233I had no effect on the binding of carbendazim but resulted in loss of a hydrogen bond between zoxamide and F200. M233 is suggested to be a unique target site for zoxamide and be very important in the function of β tubulin. PMID:26596626

  12. Tilted axis cranking covariant density functional theory and its applications

    International Nuclear Information System (INIS)

    Recent progress on tilted axis cranking covariant density functional theory (CDFT) and its applications to nuclear magnetic and antimagnetic rotation are briefly presented. In particular, the magnetic rotation band in 198Pb and the antimagnetic rotational band in 105Cd are discussed. Without any additional parameter, the experimental relation between angular momentum and rotational frequency for the magnetic rotation band in 198Pb as well as the data of B(E2) values for the antimagnetic rotation band in 105Cd are reproduced very well

  13. Contribution to the study of collective states of heavy nuclei by means of coulomb excitation

    International Nuclear Information System (INIS)

    The following nuclei were excited by protons of 5 MeV maximum energy: 182W - 184W - 186W - 186Os - 188Os - 189Os - 190Os - 192Os - 194Pt - 196Pt - 198Pt - 198Hg - 200Hg - 202Hg - 204Hg - 206Pb. The reduced probabilities of the various transitions were deduced from the coulomb excitation cross-section measurements. For some even-even nuclei two 2 + levels were excited. The properties of the excited levels are interpreted in terms of the collective model. (author)

  14. Patterns of endemism within the Karoo National Park, South Africa

    Directory of Open Access Journals (Sweden)

    F. Rubin

    2001-12-01

    Full Text Available A checklist of 864 plant taxa representing 355 genera and 93 families is given for the Karoo National Park. A total of 121 species are endemic to the Nama-Karoo, with Asteraceae the most common with 33 taxa. followed by Mesembryanthemaceae with 26 taxa. Phytochorological affinities indicate that 19.8% of the species are from the Nama- Karoo Biome only, another 19.8% are distributed over two biomes, and 41% of the species have a widespread distribution. The Karoo National Park conserves 30% of the recognized endemics of the Nama-Karoo Biome.

  15. First observation of a collective dipole rotational band in the A ≅ 200 mass region

    International Nuclear Information System (INIS)

    The nucleus 198Pb was populated via the 186W(17O, 5n)198Pb reaction at beam energies of 92 and 98 MeV. A highly regular rotational ΔI=1 band has been found. Angular correlation measurements confirm the transitions to be dipoles. Assuming M1 multipolarity for these transitions the experimental data are interpreted in terms of a π([505]9/2-x[606]13/2+)sub(Kπ=11-)xν(i13/2)2 configuration of oblate shape. This is the first such collective oblate structure identified in the A∝200 mass region. (orig.)

  16. Dicty_cDB: Contig-U10443-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available E010300 |pid:none) Leptospira interrogans serovar ... 198 2e-49 CP000143_2577( CP000143 |pid:none) Rhodobacter sphaeroides... 2.4.1 c... 198 3e-49 CP000577_2604( CP000577 |pid:none) Rhodobacter sphaeroides... ATCC 17... 197 4e-49 CP001150_2354( CP001150 |pid:none) Rhodobacter sphaeroides KD131 c... 197...4 CP000492_703( CP000492 |pid:none) Chlorobium phaeobacteroides DSM ... 182 2e-44 CP000285_1209( CP000285 |p...3e-40 CP000557_916( CP000557 |pid:none) Geobacillus thermodenitrificans ... 168 3

  17. Aphid parasitoid (Hymenoptera:Braconidae: Aphidiinae) in wetland habitats in western Palearctic: key and associated aphid parasitoid guilds

    Czech Academy of Sciences Publication Activity Database

    Tomanović, Ž.; Starý, Petr; Kavallieratos, N. G.; Gagić, V.; Plećaš, M.; Janković, M.; Rakhshani, E.; Ćetković, A.; Petrović, A.

    2012-01-01

    Roč. 48, 1-2 (2012), s. 189-198. ISSN 0037-9271 Grant ostatní: The Ministry of Science and Technological Development of the Republic of Serbia (RS) 043001 Institutional research plan: CEZ:AV0Z50070508 Keywords : aphid parasitoids * tritrophic interactions * wetlands Subject RIV: EH - Ecology, Behaviour Impact factor: 0.529, year: 2012 http://zoologie.umh.ac.be/asef/pdf/2012_48_01_02/full/Tomanovic_et_al_2012_ASEF_48_1_2_189_198_full.pdf

  18. Ce0.98Pd0.02O2-: Recyclable, ligand free palladium(II) catalyst for Heck reaction

    Indian Academy of Sciences (India)

    S R Sanjaykumar; Bhaskar Devu Mukri; Satish Patil; Giridhar Madras; M S Hegdea

    2011-01-01

    Palladium substituted in cerium dioxide in the form of a solid solution, Ce0.98 Pd0.02 O1.98 is a new heterogeneous catalyst which exhibits high activity and 100% trans-selectivity for the Heck reactions of aryl bromides including heteroaryls with olefins. The catalytic reactions work without any ligand. Nanocrystalline Ce0.98 Pd0.02 O1.98 is prepared by solution combustion method and Pd is in +2 state. The catalyst can be separated, recovered and reused without significant loss in activity.

  19. Selective blockade of growth-hormone by interstitial gamma-irradiation of the pituitary in acromegaly and diabetic retinopathy

    International Nuclear Information System (INIS)

    This report documents ocular and neuroendocrinological results in a series of 185 diabetic retinopathy implanted with 198Au, the activity was respectively 16.5 +- 0.5 and 13.5 +- 0.2 mCi in 2 groups of patients. In addition long-term data resulting from 198Au stereotactic implantations in a series of 10 GH hypersecreting adenomas (with or without supra-sellar expansion) are analysed in this study and compared with cases of permanent 192Iridium and 90Yttrium implantations in acromegaly. The main finding is the absence of immediate and/or late neurological, ocular and metabolic complications. (Auth.)

  20. The biokinetics of alpha-particle emitting radiopharmaceuticals

    International Nuclear Information System (INIS)

    The past two decades have seen wide interest in the application of alpha-particle emitting radionuclides for targeted endoradiotherapy and a large number of compounds labeled with 211At (T1/2 7.21 h), 212Bi (T1/2 1 h) or 213Bi (T1/2 0.78 h) have been studied. Knowledge of the biokinetic behaviour of such agents is important both for their optimal clinical exploitation and for general radiological protection purposes. Animal studies of the distribution and retention of 211At compounds, including ionic astatide, substituted aromatic compounds and labelled monoclonal antibodies, have provided new information on the biochemistry of astatine. With respect the thyroid gland the uptake of the astatide ion has been shown to be very much lower than that of the iodide ion. Less information is available for 212Bi-labelled radiopharmaceuticals. The available data for both 211At and 212Bi radiopharmaceuticals are reviewed. Cautious generic biokinetic models for inorganic and simple organic compounds of 211At and 212Bi; for [211At]-, and [212Bi]-biphosphonates and for [211At]-, and [212Bi]-monoclonal antibodies, are proposed for use in general radiological protection when compound-specific data are not available. (orig.)

  1. The radiolabeled monoclonal antibodies in immunoscintigraphy and radioimmunotherapy: current state and perspectives

    International Nuclear Information System (INIS)

    The antibodies can be satisfactorily labelled with technitium-99 m or indium-111 for tumor immunoscintigraphy. The immunoscintigraphy is not useful for the primary tumor diagnosis. It can be useful for the diagnosis of the some cancer extension and for recurrent tumor visualization. The immunoscintigraphy is widely competed with Positron Emission Tomography (PET) which gives accurate results. In the future the immunoscintigraphy, in pre-therapeutic stage, contribute to the estimation of the dose delivered to the tumor and to normal organs for adopting or not a radioimmunotherapy. The antibodies can also be labeled with Iodine-131 for an application in radioimmunotherapy (RIT). The RIT is efficient in the non-Hodgkin's lymphoma treatment because of their great radiosensitivity. Until now the results have been very modest in solid tumor treatment but methodological and biotechnological progresses have to improve the efficiency especially for the small tumors. In the future iodine-131 which requires the confinement (very expensive) of patients will be substituted by yttrium-90 beta emitter, more energetic than iodine-131 and can be injected in walking case. In the long term, the alpha emitter radionuclides (astatine-211 or bismuth-213) can be used for hematologic cancer treatment. In conclusion the future of radiolabeled monoclonal antibodies is essentially therapeutic. The radioimmunotherapy associated to the chemotherapy give promising perspectives for the radiosensitive cancer treatment and in general small solid tumor treatment (F.M.)

  2. Biological toxicity of intracellular radionuclide decay. Part of a coordinated programme on radiation biology of Auger emitters and their therapeutic applications

    International Nuclear Information System (INIS)

    Internal radiotherapy should be performed with short-lived radionuclides which emit high LET radiation and short ranged radiation, and accumulated within cancers. Based on these considerations, several radionuclides (tritium, copper-64, gallium-67, iodine-123, iodine 125, iodine-131 and astatine-211) were chosen and their toxicity was assessed using cell division in mammalian cultured cells as a criterion. It was apparent that the toxic effects obtained with 125I greatly exceeded those observed in cells treated with any other radionuclides. The possible hypotheses to explain the excessive radiosensitivity of 125I were discussed in relation to microdosimetry calculation. It was also found that the division delay induced by radionuclide decay is primarily due to damage to the cell nucleus but not to the plasma membrane. The key problem remains the development of agents which can serve as carriers for radionuclide accumulation within tumors. Although several promising approaches (Synkavit, tamoxifen, iododeoxyuridine, antibodies, liposomes) were investigated, only 125I-labelled Synkavit would be desirable for clinical application

  3. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  4. The biokinetics of alpha-particle emitting radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, D.M. [School of Chemistry, Cardiff Univ., Cardiff (United Kingdom); Duffield, J.R. [Faculty of Applied Sciences, Univ. of the West of England, Bristol (United Kingdom)

    2005-07-01

    The past two decades have seen wide interest in the application of alpha-particle emitting radionuclides for targeted endoradiotherapy and a large number of compounds labeled with {sup 211}At (T{sup 1}/{sub 2} 7.21 h), {sup 212}Bi (T{sup 1}/{sub 2} 1 h) or {sup 213}Bi (T{sup 1}/{sub 2} 0.78 h) have been studied. Knowledge of the biokinetic behaviour of such agents is important both for their optimal clinical exploitation and for general radiological protection purposes. Animal studies of the distribution and retention of {sup 211}At compounds, including ionic astatide, substituted aromatic compounds and labelled monoclonal antibodies, have provided new information on the biochemistry of astatine. With respect the thyroid gland the uptake of the astatide ion has been shown to be very much lower than that of the iodide ion. Less information is available for {sup 212}Bi-labelled radiopharmaceuticals. The available data for both {sup 211}At and {sup 212}Bi radiopharmaceuticals are reviewed. Cautious generic biokinetic models for inorganic and simple organic compounds of {sup 211}At and {sup 212}Bi; for [{sup 211}At]-, and [{sup 212}Bi]-biphosphonates and for [{sup 211}At]-, and [{sup 212}Bi]-monoclonal antibodies, are proposed for use in general radiological protection when compound-specific data are not available. (orig.)

  5. Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

    International Nuclear Information System (INIS)

    Aim: The monoclonal antibody cetuximab, targeting the epidermal growth factor receptor (EGFR), is a promising molecular targeting agent to be used in combination with radiation for anticancer therapy. In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed. Methods: SCC cell lines were characterized and treated with cetuximab in combination with anti-CD44v6 RIT using the astatinated chimeric monoclonal antibody U36 (211At-cMAb U36). Effects on 211At-cMAb U36 uptake, internalization and cell proliferation were then assessed in SCC cells. Results: Cetuximab in combination with 211At-cMAb U36 mediated increased growth inhibition compared to RIT or cetuximab alone in two cell lines. However, cetuximab also mediated radioprotective effects compared to RIT alone in two cell lines. The radioprotective effects occurred in the cell lines in which cetuximab clearly inhibited cell growth during radiation exposure. Cetuximab treatment also influenced 211At-cMAb-U36 uptake and internalization, suggesting interactions between CD44v6 and EGFR. Conclusions: Results from this study demonstrate the vast importance of further clarifying the mechanisms of cetuximab and radiation response, and the relationship between EGFR and suitable RIT targets. This is important not only in order to avoid potential radioprotective effects, but also in order to find and utilize potential synergistic effects from these combinations.

  6. Tumor immunotargeting using innovative radionuclides.

    Science.gov (United States)

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  7. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  8. Proceedings of transuranium elements

    International Nuclear Information System (INIS)

    The identification of the first synthetic elements was established by chemical evidence. Conclusive proof of the synthesis of the first artificial element, technetium, was published in 1937 by Perrier and Segre. An essential aspect of their achievement was the prediction of the chemical properties of element 43, which had been missing from the periodic table and which was expected to have properties similar to those of manganese and rhenium. The discovery of other artificial elements, astatine and francium, was facilitated in 1939-1940 by the prediction of their chemical properties. A little more than 50 years ago, in the spring of 1940, Edwin McMillan and Philip Abelson synthesized element 93, neptunium, and confirmed its uniqueness by chemical means. On August 30, 1940, Glenn Seaborg, Arthur Wahl, and the late Joseph Kennedy began their neutron irradiations of uranium nitrate hexahydrate. A few months later they synthesized element 94, later named plutonium, by observing the alpha particles emitted from uranium oxide targets that had been bombarded with deuterons. Shortly thereafter they proved that is was the second transuranium element by establishing its unique oxidation-reduction behavior. The symposium honored the scientists and engineers whose vision and dedication led to the discovery of the transuranium elements and to the understanding of the influence of 5f electrons on their electronic structure and bonding. This volume represents a record of papers presented at the symposium

  9. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  10. Development and radiotherapeutic application of 211At-labeled radiopharmaceuticals. Progress report, March 1, 1981-February 28, 1982

    International Nuclear Information System (INIS)

    This project is concerned with developing the potential of alpha-emitting radionuclides as agents for radiotherapy. Alpha-emitters seem ideally suited for his application because their high linear energy transfer and short range permit the deposition of considerable energy in a very small volume of tissue. Unlike the beta particles of 131I which have a range of about 1 to 2 mm in tissue, 5 to 7 MeV alpha particles would traverse only a few cell diameters. Among the available alpha-emitters, 211At appears most promising for therapeutic applications because, (1) it has some chemical similarities to iodine, an element that can readily be incorporated into numerous proteins and peptides, (2) it has a half-life that is long enough to permit chemical manipulation yet short enough to minimize destruction of healthy cells due to degradation of the label over time, (3) it can be produced conveniently using a cyclotron, and (4) alpha emission is associated with 100% of its decays with no accompanying beta emission. In the past year the evaluation of an astatine-tellurium colloid as an agent for the destruction of malignant ascites has been completed. The therapeutic efficacy of 211At-tellurium colloid has been compared with that of several beta-emitting radiocolloids. Studies on the application of monoclonal antibodies as carriers for selective delineation and destruction of malignant cell populations have also been initiated

  11. Nuclear and chemical data for life sciences

    International Nuclear Information System (INIS)

    Use of reactor produced radionuclides is popular in life sciences. However, cyclotron production of proton rich radionuclides are being more focused in recent times. These radionuclides have already gained attention in various fields, including life sciences, provided they are obtained in pure form. This article is a representative brief of our contributions in generating nuclear data for the production of proton rich radionuclides of terbium, astatine, technetium, ruthenium, cadmium, niobium, zirconium, rhenium, etc., which may have application in clinical, biological, agriculture studies or in basic research. The chemical data required to separate the product isotopes from the corresponding target matrix have been presented along with a few propositions of radiopharmaceuticals. It also emphasizes on the development of simple empirical technique, based on the nuclear reaction model analysis, to generate reliable nuclear data for the estimation of yield and angular distribution of emitted neutrons and light charged particles from light as well as heavy ion induced reactions on thick stopping targets. These data bear utmost important in radiation dosimetry. (author)

  12. Studies of Stable Octupole Deformations in the Radium Region

    CERN Multimedia

    2002-01-01

    The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

  13. Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Nestor, Marika, E-mail: marika.nestor@bms.uu.s [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden); Sundstroem, Magnus [Unit of Molecular Pathology, Department of Genetics and Pathology, Uppsala University (Sweden); Anniko, Matti [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Tolmachev, Vladimir [Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden)

    2011-01-15

    Aim: The monoclonal antibody cetuximab, targeting the epidermal growth factor receptor (EGFR), is a promising molecular targeting agent to be used in combination with radiation for anticancer therapy. In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed. Methods: SCC cell lines were characterized and treated with cetuximab in combination with anti-CD44v6 RIT using the astatinated chimeric monoclonal antibody U36 ({sup 211}At-cMAb U36). Effects on {sup 211}At-cMAb U36 uptake, internalization and cell proliferation were then assessed in SCC cells. Results: Cetuximab in combination with {sup 211}At-cMAb U36 mediated increased growth inhibition compared to RIT or cetuximab alone in two cell lines. However, cetuximab also mediated radioprotective effects compared to RIT alone in two cell lines. The radioprotective effects occurred in the cell lines in which cetuximab clearly inhibited cell growth during radiation exposure. Cetuximab treatment also influenced {sup 211}At-cMAb-U36 uptake and internalization, suggesting interactions between CD44v6 and EGFR. Conclusions: Results from this study demonstrate the vast importance of further clarifying the mechanisms of cetuximab and radiation response, and the relationship between EGFR and suitable RIT targets. This is important not only in order to avoid potential radioprotective effects, but also in order to find and utilize potential synergistic effects from these combinations.

  14. Alpha particle emitters in medicine

    International Nuclear Information System (INIS)

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 (211At) and natural bismuth-212 (212Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 (223Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs

  15. Preparation of 211At-labeled humanized anti-Tac using 211At produced in disposable internal and external bismuth targets

    International Nuclear Information System (INIS)

    These studies describe the production and purification of 211At as well as the procedure for labeling humanized anti-Tac, the antibody to the α-chain of the IL-2 receptor (IL-2Rα), which has been shown to be a useful target for immunotherapy. The optimized protocol combines the advantages of the two-stage dry distillation procedure with the astatination of trialkylstannyl substances as labeling compounds for proteins. The 211At was produced by bombarding either an external or a recently developed disposable internal bismuth target with α-particles from a Cyclotron Corporation CS-30 cyclotron. The 211At was found to contain less than 0.01% 210At. The production rate for the external target was 0.15 mCi ± 0.056 μA-1 h-1 (n = 9) (5.55 MBq μA-1 h-1). The production rate for the internal target was 0.44 ± 0.14 mCi μA-1 h-1 (n = 16) (16.28 MBq μA-1 h-1)

  16. 46. annual meeting of the Deutsche Geophysikalische Gesellschaft e.V. Joint symposium of the ILP/SFB 108 on the continental lithosphere - structure, composition and processes

    International Nuclear Information System (INIS)

    198 papers were read on continental lithosphere investigations. Physical, and especially seismic methods were given particular attention. Geothermal exploration, safety studies on salt strata, and the identification of nuclear weapons tests were gone into. Separate records are available for 22 papers. (PW)

  17. Students' and teachers' cognitions about good teachers

    NARCIS (Netherlands)

    J.J. Beishuizen; E. Hof; C.M. van Putten; S. Bouwmeester; J.J. Asscher

    2001-01-01

    Examined what students think about good teachers. 198 students of 4 age groups (7, 10, 13, and 16 yrs old) and teachers from primary and secondary schools were asked to write an essay on the good teacher. The correspondence between conceptual items in the essays was investigated. The analysis reveal

  18. Association between ventilation rates in 390 Swedish homes and allergic symptoms in children

    DEFF Research Database (Denmark)

    Bornehag, Carl Gustaf; Sundell, Jan; Hagerhed-Engman, L.;

    2005-01-01

    The aim of the study was to test the hypothesis that a low-ventilation rate in homes is associated with an increased prevalence of asthma and allergic symptoms among children. A total of 198 cases (with at least two of three symptoms: wheezing, rhinitis, eczema) and 202 healthy controls, living i...

  19. Phase relations and structural features in the system Ni-Zn-B

    Czech Academy of Sciences Publication Activity Database

    Malik, Z.; Grytsiv, A.; Rogl, P.; Giester, G.; Buršík, Jiří

    2013-01-01

    Roč. 198, FEB (2013), s. 150-161. ISSN 0022-4596 Institutional support: RVO:68081723 Keywords : Ni-Zn borides * Ni-Zn-B phase equilibria * crystal strucrure Subject RIV: BJ - Thermodynamics Impact factor: 2.200, year: 2013

  20. The astrophysical consequences of the bimodal hydrodynamic solution of the super star cluster winds

    Czech Academy of Sciences Publication Activity Database

    Palouš, Jan; Wünsch, Richard; Tenorio-Tagle, G.; Silich, S.

    2009-01-01

    Roč. 324, 2-4 (2009), s. 195-198. ISSN 0004-640X R&D Projects: GA MŠk(CZ) LC06014 Institutional research plan: CEZ:AV0Z10030501 Keywords : stellar wind s * star cluster s * HII regions Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.404, year: 2009

  1. Dicty_cDB: Contig-U10483-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ties = 198/207 (95%) Strand = Plus / Plus Query: 11 attgnttttatcanccnaaaatnatgaat...taggnccngcntntcanangaaacntttaaa 70 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 11 attgnttttatcanccna...3) = 9e-30 Identities = 65/65 (100%) Strand = Plus / Minus Query: 11 attgnttttatcanccnaaaatnatgaattaggnccngc...ntntcanangaaacntttaaa 70 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 349 attgnttttatcanccna

  2. Andrej Voznesenskij - ot paraboly k krugu

    Czech Academy of Sciences Publication Activity Database

    Ulbrechtová, Helena

    Brno: Masarykova univerzita v Brně, 2006 - (Dohnal, J.), s. 191-198 ISBN 80-210-4179-X. [Problémy poetiky. Brno (CZ), 20.10.2006-21.10.2006] Institutional research plan: CEZ:AV0Z90920516 Keywords : Russian Poetry Subject RIV: AJ - Letters, Mass-media, Audiovision

  3. The Use of Internet of EFL Learners

    Science.gov (United States)

    Srichanyachon, A. Napaporn

    2013-01-01

    This study investigated attitudes toward using the Internet as a learning tool among students at Bangkok University; students' expectation of social networks and search engines in learning English, as well as their perceived usefulness. It also examined their use of the Internet for learning English. The samples were 198 undergraduate…

  4. Dicty_cDB: Contig-U13698-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 198 ) EST_cclu_evb_461716 ccluevb mixed_tissue Coregonu... 44 6.1 1 ( EV250197 ) ...EST_cclu_evb_461332 ccluevb mixed_tissue Coregonu... 44 6.1 1 ( U97002 ) Caenorhabditis elegans cosmid K09H1

  5. 7 CFR 1726.175 - General plant materials.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES General Plant § 1726.175 General plant... equipment. (a) Contract forms. The borrower may, in its discretion, use RUS Form 198, Equipment Contract, or... equipment. (c) Contract approval. Contracts for the purchase of general plant items are not subject to...

  6. 7 CFR 1726.402 - Equipment contract closeout.

    Science.gov (United States)

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Contract Closeout § 1726.402 Equipment contract closeout. This section is applicable to contracts executed on RUS Form 198. (a) Final... 7 Agriculture 11 2010-01-01 2010-01-01 false Equipment contract closeout. 1726.402 Section...

  7. Characterization of polyaniline-based ammonia gas sensors prepared by means of spray coating and ink-jet printing

    Czech Academy of Sciences Publication Activity Database

    Peřinka, N.; Držková, M.; Randjelović, D. V.; Bondavalli, P.; Hajná, Milena; Bober, Patrycja; Syrový, T.; Bonnassieaux, Y.; Stejskal, Jaroslav

    2014-01-01

    Roč. 12, č. 11 (2014), s. 1620-1627. ISSN 1546-198X R&D Projects: GA TA ČR TE01020022; GA ČR(CZ) GP14-05568P Institutional support: RVO:61389013 Keywords : polyaniline * poly(N-vinylpyrrolidone) * dispersion Subject RIV: CG - Electrochemistry Impact factor: 0.558, year: 2013

  8. Characterization of two closely related α-amylase paralogs in the bark beetle, Ips typographus (L.)

    Czech Academy of Sciences Publication Activity Database

    Viktorinová, I.; Kučerová, Lucie; Böhmová, Marta; Henry, I.; Jindra, Marek; Doležal, Petr; Žurovcová, Martina; Žurovec, Michal

    2011-01-01

    Roč. 77, č. 4 (2011), s. 179-198. ISSN 0739-4462 EU Projects: European Commission(CZ) FP7/2007-2013 Institutional research plan: CEZ:AV0Z50070508 Keywords : bark beetle * intron polymorphism * α-amylase Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.361, year: 2011

  9. 76 FR 30322 - Notice of Availability of Government-Owned Inventions; Available for Licensing

    Science.gov (United States)

    2011-05-25

    ... Number 7,661,271 entitled ``Integrated Electric Gas Turbine'' issued on February 16, 2010; U.S. Patent..., 2004; U.S. Patent Number 6,624,780 entitled ``False Target Radar Image Generator for Countering... 7,675,198 entitled ``Inductive Pulse Forming Network for High-current, High-power...

  10. The Best and the Rest: Revisiting the Norm of Normality of Individual Performance

    Science.gov (United States)

    O'Boyle, Ernest, Jr.; Aguinis, Herman

    2012-01-01

    We revisit a long-held assumption in human resource management, organizational behavior, and industrial and organizational psychology that individual performance follows a Gaussian (normal) distribution. We conducted 5 studies involving 198 samples including 633,263 researchers, entertainers, politicians, and amateur and professional athletes.…

  11. Inhibitory activity of chlorogenic acids in decaffeinated green coffee beans against porcine pancreas lipase and effect of a decaffeinated green coffee bean extract on an emulsion of olive oil.

    Science.gov (United States)

    Narita, Yusaku; Iwai, Kazuya; Fukunaga, Taiji; Nakagiri, Osamu

    2012-01-01

    A decaffeinated green coffee bean extract (DGCBE) inhibited porcine pancreas lipase (PPL) activity with an IC50 value of 1.98 mg/mL. Six different chlorogenic acids in DGCBE contributed to this PPL inhibition, accounting for 91.8% of the inhibitory activity. DGCBE increased the droplet size and decreased the specific surface area of an olive oil emulsion. PMID:23221697

  12. THE IMPACTS OF DAIRY CATTLE OWNERSHIP ON THE NUTRITIONAL STATUS OF PRE-SCHOOL CHILDREN IN COASTAL KENYA

    OpenAIRE

    Nicholson, Charles F.; Thornton, Philip K.

    1999-01-01

    Anthropometric measurements for children and household characteristics were collected form 198 households in coastal Kenya to examine the impacts of dairy technology adoption on nutritional status. Random effects models indicate that dairy technology adoption positively influences chronic malnutrition, but that dairy consumption has a larger impact than adoption per se.

  13. alpha-Tocopheryloxyacetic acid is superior to alpha-tocopheryl succinate in suppressing HER2-high breast carcinomas due to its higher stability

    Czech Academy of Sciences Publication Activity Database

    Dong, L. F.; Grant, G.; Massa, H.; Zobalová, Renata; Akporiaye, E.; Neužil, Jiří

    2012-01-01

    Roč. 131, č. 5 (2012), s. 1052-1058. ISSN 0020-7136 R&D Projects: GA ČR GAP301/10/1937; GA AV ČR(CZ) KAN200520703 Institutional research plan: CEZ:AV0Z50520701 Keywords : Breast cancer * vitamin E analogs * apoptosis induction Subject RIV: CE - Biochemistry Impact factor: 6.198, year: 2012

  14. Psychosocial Adjustment of College Students with Tattoos and Piercings

    Science.gov (United States)

    Roberti, Jonathan W.; Storch, Eric A.

    2005-01-01

    The purpose of this study was to examine the association between body modification practices and psychosocial adjustment. Participants were 198 undergraduate college students, 129 of whom had I or more piercings (other than in earlobe) or tattoos. Findings showed that individuals with body modifications reported more symptoms of depression and…

  15. Examining Life Goals and School Attendance Rates of Afghan Students Receiving Higher Education in Turkey

    Science.gov (United States)

    Bek, Hafiz

    2016-01-01

    This research is a descriptive study carried out to examine the relations between life goals and school attendance levels among Afghan students receiving higher education in Turkey. In total there were 198 Afghan students that participated in the study. Among which 159 were male and 39 female. All of these students were studying in 16 Turkish…

  16. Acute Respiratory Infections in Travelers Returning from MERS-CoV–Affected Areas

    OpenAIRE

    German, Matthew; Olsha, Romy; Kristjanson, Erik; Marchand-Austin, Alex; Peci, Adriana; Winter, Anne-Luise; Gubbay, Jonathan B.

    2015-01-01

    We examined which respiratory pathogens were identified during screening for Middle East respiratory syndrome coronavirus in 177 symptomatic travelers returning to Ontario, Canada, from regions affected by the virus. Influenza A and B viruses (23.1%) and rhinovirus (19.8%) were the most common pathogens identified among these travelers.

  17. Narratives as a Tool for Understanding the Inner Side of Dance in a Socio-Cultural and Political Context

    Czech Academy of Sciences Publication Activity Database

    Stavělová, Daniela

    Zagreb: Institute of Ethnology and Folklore Research, 2015 - (Dunin, E.), s. 198-203 ISBN 978-953-6020-98-0. [28th Symposium of the ICTM Study Group on Ethnochoreology. Korčula (HR), 07.07.2014-17.07.2014] Institutional support: RVO:68378076 Keywords : dance * folklore movement * oral history * narratives * Czech Republic Subject RIV: AC - Archeology, Anthropology, Ethnology

  18. Rozvoj plastických deformací v oceli při konstantním zatížení a jejich význam pro plynárenskou praxi

    Czech Academy of Sciences Publication Activity Database

    Gajdoš, Lubomír; Šperl, Martin; Pařízek, P.

    2013-01-01

    Roč. 93, č. 9 (2013), s. 198-203. ISSN 0032-1761 R&D Projects: GA ČR(CZ) GAP105/10/2052 Institutional support: RVO:68378297 Keywords : low-temperature creep * deformation * pipe Subject RIV: JL - Materials Fatigue, Friction Mechanics

  19. Palynology of the Bohemian part of the Intra-Sudetic Basin (Bashikirian-Kasimovian B), Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Bek, Jiří

    Prague : National Museum, 2006. s. 13-13. ISBN 80-7036-198-0. [European Palaeobotany- Palynology Conference /7./. 06.09.2006-11.09.2006, Prague] R&D Projects: GA AV ČR IAA3013306 Institutional research plan: CEZ:AV0Z30130516 Keywords : palynology * Intra-Sudetic Basin * dispersed spores Subject RIV: EF - Botanics

  20. Vegetation changes and development dynamic on the example of the palyno-assemblages in the Cheb Basin, Western part of the Ohře rift, within 40.4 MA to 1.8 MA (summary stratigraphical profile from the western part of the Ohře Rift, Czech Republic - palaeogene to Pliocene)

    Czech Academy of Sciences Publication Activity Database

    Konzalová, Magda; Stuchlik, L.

    Prague : National Museum, 2006. ISBN 80-7036-198-0. [European Palaeobotany- Palynology Conference /7./. 06.09.2006-11.09.2006, Prague] Institutional research plan: CEZ:AV0Z30130516 Keywords : vegetation changes * Pliocene * palynology * Cheb Basin, Czech Republic Subject RIV: EF - Botanics

  1. Phylogeny and relationship of some isoetalean spores from the Devonian to the present

    Czech Academy of Sciences Publication Activity Database

    Bek, Jiří; Drábková, J.; Dašková, Jiřina; Chitaley, S.

    Prague : National Museum, 2006. s. 13-13. ISBN 80-7036-198-0. [European Palaeobotany- Palynology Conference /7./. 06.09.2006-11.09.2006, Prague] R&D Projects: GA AV ČR IAA3013902 Institutional research plan: CEZ:AV0Z30130516 Keywords : Isoetes * Polysporia * phylogeny * in situ spores * Palaeozoic Subject RIV: EF - Botanics

  2. Division of carboniferous lycospores

    Czech Academy of Sciences Publication Activity Database

    Bek, Jiří

    Prague : National Museum, 2006. s. 12-12. ISBN 80-7036-198-0. [European Palaeobotany- Palynology Conference /7./. 06.09.2006-11.09.2006, Prague] R&D Projects: GA AV ČR IAA3013902 Institutional research plan: CEZ:AV0Z30130516 Keywords : lycospores * palynology * Carboniferous Subject RIV: EF - Botanics

  3. Carboniferous and permian noeggerathialean plants and their spores; preliminary report

    Czech Academy of Sciences Publication Activity Database

    Bek, Jiří; Wang, J.

    Prague : National Museum, 2006. ISBN 80-7036-198-0. [European Palaeobotany- Palynology Conference /7./. 06.09.2006-11.09.2006, Prague] R&D Projects: GA AV ČR IAA3013902 Institutional research plan: CEZ:AV0Z30130516 Keywords : Noeggerathiales * in situ spores * Palaeozoic-Permian Subject RIV: EF - Botanics

  4. Proposal of the new classification of Palaeozoic Sphenophyllalean cones

    Czech Academy of Sciences Publication Activity Database

    Libertín, M.; Bek, Jiří

    Prague : National Museum, 2006. ISBN 80-7036-198-0. [European Palaeobotany- Palynology Conference /7./. 06.09.2006-11.09.2006, Prague] R&D Projects: GA AV ČR IAA3013902 Institutional research plan: CEZ:AV0Z30130516 Keywords : sphenophylls * in situ spores * Palaeozoic Subject RIV: EF - Botanics

  5. Macroremains of cultural and wild plants from Early Medieval to Early Modern archaeological situations in the centre of Prague-areas of Pražský hrad (Prague castle) and of Malá Strana (Lesser Town)

    Czech Academy of Sciences Publication Activity Database

    Čulíková, Věra

    Praha : National Museum Prague, 2006. s. 27-28. ISBN 80-7036-198-0. [7th European Palaeobotany- Palynology Conference. 06.09.2006-11.09.2006, Praha] Institutional research plan: CEZ:AV0Z80020508 Keywords : palynology * macroremains Subject RIV: AC - Archeology, Anthropology, Ethnology

  6. Micropalaeontological (Palynological) Records of the Ohře Rift

    Czech Academy of Sciences Publication Activity Database

    Konzalová, Magda

    Prague : National Museum, 2006. ISBN 80-7036-198-0. [European Palaeobotany- Palynology Conference /7./. 06.09.2006-11.09.2006, Prague] R&D Projects: GA AV ČR IAA300130612 Institutional research plan: CEZ:AV0Z30130516 Keywords : Plant microfossils * neovolcanics * Ohře River Rift, * Paleogene * NW Bohemia Subject RIV: EF - Botanics

  7. Sternbergites gen. nov., a new sub-arborescent isosporous compression-lycopsid from the Pennsylvanian of the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Drábková, J.; Libertín, M.; Bek, Jiří; Opluštil, S.

    Prague : National Museum, 2006. s. 35. ISBN 80-7036-198-0. [European Palaeobotany- Palynology Conference /7./. 06.09.2006-11.09.2006, Prague] R&D Projects: GA ČR GA205/05/0105 Institutional research plan: CEZ:AV0Z30130516 Keywords : Sternbergites * Spencerites * Spencerisporites * lycopsids Subject RIV: EF - Botanics

  8. Early Normapolles evolution in the Upper Cretaceous, Cenomanian and Turonian, in France and the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Méon, H.; Svobodová, Marcela; Guignard, G.; Pacltová, B.

    Prague : National Museum, 2006. ISBN 80-7036-198-0. [European Palaeobotany- Palynology Conference /7./. 06.09.2006-11.09.2006, Prague] Institutional research plan: CEZ:AV0Z30130516 Keywords : Cretaceous * Normapolles * France * Czech Republic Subject RIV: EF - Botanics

  9. Ferns of the Bohemian and their in situ spores

    Czech Academy of Sciences Publication Activity Database

    Dašková, Jiřina; Kvaček, J.

    Prague : National Museum, 2006. s. 28-28. ISBN 80-7036-198-0. [European Palaeobotany- Palynology Conference /7./. 06.09.2006-11.09.2006, Prague] Institutional research plan: CEZ:AV0Z30130516 Keywords : fern * cenomanian * spores Subject RIV: EF - Botanics

  10. Diversity of vegetation types and modern pollen spectra in the Western Sayan Mts., Southern Siberia

    Czech Academy of Sciences Publication Activity Database

    Lučeničová, B.; Kuneš, P.; Jankovská, Vlasta; Svobodová, Helena; Chytrý, M.; Danihelka, J.; Ermakov, N.; Hájek, M.; Hájková, P.; Havlová, Marie; Kočí, M.; Kubešová, S.; Lustyk, P.; Otýpková, Z.; Roleček, J.; Šmarda, P.; Valachovič, M.

    Praha : National Museum Prague, 2006, s. 83-84. ISBN 80-7036-198-0. [7th European Palaeobotany- Palynology Conference. Praha (CZ), 06.09.2006-11.09.2006] Institutional research plan: CEZ:AV0Z60050516 Keywords : pollenanalysis * phytocenologie * Siberia Subject RIV: EF - Botanics

  11. primitive gallery forest from the Intrasudetic Basins (Duckmantian, Czech Republic)

    Czech Academy of Sciences Publication Activity Database

    Libertín, M.; Dašková, Jiřina

    Prague : National Museum, 2006. s. 82-83. ISBN 80-7036-198-0. [European Palaeobotany- Palynology Conference /7./. 06.09.2006-11.09.2006, Prague] Institutional research plan: CEZ:AV0Z30130516 Keywords : fossil plants * palynology * late Palaeozoic Subject RIV: EF - Botanics

  12. Electron beam welding of stainless steel with tungsten, tantalum and molybdenum

    Czech Academy of Sciences Publication Activity Database

    Dupák, Jan; Michalička, Petr; Ustohal, V.; Kuchyňka, R.

    Varna : Institute of Electronics BAS, 2003, s. 198 - 201. [EBT 2003. Varna (BG), 01.06.2003-06.06.2003] Institutional research plan: CEZ:AV0Z2041904; CEZ:AV0Z2065902 Keywords : very high temperature * special materials * electron-beam welding Subject RIV: BM - Solid Matter Physics ; Magnetism

  13. Sustainability and international solidarity

    Czech Academy of Sciences Publication Activity Database

    Suša, Oleg

    Amsterdam: ALLEA, 2006 - (Drenth, P.; Honnefelder, L.; Schroots, J.), s. 189-198. (ALLEA report series. 4). ISBN 90-6984-504-0 R&D Projects: GA MŠk(CZ) LC06013 Institutional research plan: CEZ:AV0Z90090514 Keywords : sustainability * solidarity Subject RIV: AA - Philosophy ; Religion

  14. Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis

    DEFF Research Database (Denmark)

    Gombart, Adrian F; Bhan, Ishir; Borregaard, Niels;

    2009-01-01

    hemodialysis. Case patients (n = 81) were those who died of an infectious disease within 1 year; control patients (n = 198) were those who survived at least 1 year while undergoing dialysis. RESULTS: Mean (+/-SD) baseline levels of hCAP18 in case patients and control patients were 539 +/- 278 ng/mL and 650...

  15. Bachelor of Social Work Students and Mental Health Stigma: Understanding Student Attitudes

    Science.gov (United States)

    Zellmann, Karen T.; Madden, Elissa E.; Aguiniga, Donna M.

    2014-01-01

    Bachelor-level social work students (n = 198) at a midsized Midwestern public university were surveyed to evaluate their attitudes toward those with mental health concerns. Additionally, students were surveyed regarding their willingness to seek treatment for their own mental health needs. Results of the analyses suggest that the majority of…

  16. Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma

    Czech Academy of Sciences Publication Activity Database

    Altanerova, V.; Cihova, M.; Babič, Michal; Rychly, B.; Ondicova, K.; Mravec, B.; Altaner, C.

    2012-01-01

    Roč. 130, č. 10 (2012), s. 2455-2463. ISSN 0020-7136 Institutional research plan: CEZ:AV0Z40500505 Keywords : glioblastoma * mesenchymal stem cells * suicide gene therapy Subject RIV: CD - Macromolecular Chemistry Impact factor: 6.198, year: 2012

  17. Improved polyacrylamide matrixes for separation of branched glycans – structural and chromatographic features

    Czech Academy of Sciences Publication Activity Database

    Guryča, Vilém; Novotný, M. V.; Palm, A. K.; Michálek, Jiří; Pacáková, V.

    Pardubice: Univerzita Pardubice, 2005. s. 198. ISBN 80-7194-771-7. [International Symposium on Separation Sciences /11./. 12.09.2005-14.09.2005, Pardubice] Institutional research plan: CEZ:AV0Z40500505 Keywords : polyacrylamide monoliths * capillary electrochromatography * separation of oligosaccharides Subject RIV: CD - Macromolecular Chemistry

  18. Zpráva o životě a smrti Virginie Woolfové

    Czech Academy of Sciences Publication Activity Database

    Čermák, Ivo

    Praha: Národní divadlo Činohra, 2005 - (O’Brien, E.), s. 45-58 ISBN 80-7258-198-8 R&D Projects: GA AV ČR(CZ) IAA7025402 Keywords : factors of suicidial development * creativity * life-story Subject RIV: AN - Psychology

  19. AcEST: DK961817 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TST39A01NGRL0011_D05 697 Adiantum capillus-veneris mRNA. clone: TST39A01NGRL0011_D05. 5' end seq ... itives = 12/13 (92%) Frame = +3 Query: 198 WLPKWLPRPSG HP 236 W+P+WLP+PSG ... P Sbjct: 4 WIPQWLPQPSG RP 16 >sp| ...

  20. The effect of fire on lipid compisition of eucalypts soils in north-central Portugal

    OpenAIRE

    Faria, Silvia Regina; Rosa Arranz, José M. de la; González-Pérez, José Antonio; Villaverde Capellán, J.; Keizer, Jakob

    2013-01-01

    2 pages, 1 figure, 3 references.-- Póster presentado al citado congreso en la Sesión II: Soil (S) Nº 198.-- Book of Abstracts of the Communications presented to the 26th International Meeting on Organic Geochemistry (IMOG), held in Costa Adeje, Tenerife – Spain, September 15 – 20, 2013.

  1. 77 FR 23300 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Order Approving a Proposed Rule Change To...

    Science.gov (United States)

    2012-04-18

    ..., 2012), 77 FR 15152 (``Notice''). II. Background BATS Trading is a broker-dealer that is a member of the... (September 13, 2010), 75 FR 57097 (September 17, 2010) (SR-BATS- 2010-024). \\5\\ See Securities Exchange Act Release No. 62716 (August 13, 2010), 75 FR 51295 (August 19, 2010) (File No. 10-198) (order granting...

  2. Molecular Characterization of a Heterothallic Mating System in Pseudogymnoascus destructans, the Fungus Causing White-Nose Syndrome of Bats

    Czech Academy of Sciences Publication Activity Database

    Palmer, J.M.; Kubátová, Alena; Nováková, Alena; Minnis, A.M.; Kolařík, Miroslav; Lindner, D.L.

    2014-01-01

    Roč. 4, č. 9 (2014), s. 1755-1763. ISSN 2160-1836 R&D Projects: GA ČR(CZ) GAP506/12/1064 Institutional support: RVO:61388971 Keywords : geomyces * sexual reproduction * mating type Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.198, year: 2014

  3. 75 FR 58011 - Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing of Proposed Minor Rule...

    Science.gov (United States)

    2010-09-23

    ... Release No. 21013 (June 1, 1984), 49 FR 23828 (June 8, 1984). Any disciplinary action taken by an SRO.... 62716 (August 13, 2010), 75 FR 51295 (August 19, 2010) (File No. 10-198). According to the Exchange's... COMMISSION Self-Regulatory Organizations; BATS Y-Exchange, Inc.; Notice of Filing of Proposed Minor...

  4. 77 FR 23294 - Self-Regulatory Organizations; BATS Exchange, Inc.; Order Approving a Proposed Rule Change To...

    Science.gov (United States)

    2012-04-18

    ..., 2012), 77 FR 15153 (``Notice''). II. Background BATS Trading is a broker-dealer that is a member of the... Exchange Act Release No. 62901 (September 13, 2010), 75 FR 57097 (September 17, 2010) (SR-BATS-2010-024.... 62716 (August 13, 2010), 75 FR 51295 (August 19, 2010) (File No. 10-198) (Order granting the...

  5. Molecular characterization of a heterothallic mating system in .i.Pseudogymnoascus destructans./i., the fungus causing white-nose syndrome of bats

    Czech Academy of Sciences Publication Activity Database

    Palmer, J.M.; Kubátová, A.; Nováková, Alena; Minnis, A.M.; Kolařík, M.; Lindner, D.L.

    2014-01-01

    Roč. 4, č. 9 (2014), s. 1755-1763. ISSN 2160-1836 Institutional support: RVO:60077344 Keywords : Genetics of Sex * geomyces * mating type * sexual reproduction * white-nose syndrome Subject RIV: EE - Microbiology, Virology Impact factor: 3.198, year: 2014

  6. Changes in nonpolar aldehydes in bean cotyledons during ageing

    Czech Academy of Sciences Publication Activity Database

    Wilhelmová, Naděžda; Domingues, P.; Srbová, M.; Fuksová, H.; Wilhelm, J.

    2006-01-01

    Roč. 50, č. 4 (2006), s. 559-564. ISSN 0006-3134 R&D Projects: GA ČR GA522/03/0312 Institutional research plan: CEZ:AV0Z50380511 Keywords : Ageing * aldehydes * lipid peroxidation * lipofuscin-like pigments (LFP) Subject RIV: CE - Biochemistry Impact factor: 1.198, year: 2006

  7. Why Do We Do What We Do? Lifelong Learning and Consumer Behavior

    Science.gov (United States)

    Shirk, John C.

    2004-01-01

    My interviews in this study are a continuation of research into adult learning (Shirk, 1984, 1986, 1996. 1998). Based on personal interviews with 198 respondents, I attempted to portray the states of mind most adults face when learning something new. Now, in these twenty-nine interviews, I continue that process, focusing more intently, however, on…

  8. Heterogeneous ion-exchange membranes based on sulfonated poly(1,4-phenylene sulfide)

    Czech Academy of Sciences Publication Activity Database

    Schauer, Jan; Kůdela, Vlastimil; Richau, K.; Mohr, R.

    2006-01-01

    Roč. 198, 1-3 (2006), s. 256-264. ISSN 0011-9164 R&D Projects: GA ČR GA203/05/0080 Institutional research plan: CEZ:AV0Z40500505 Keywords : poly(1,4-phenylene sulfide) sulfonated * ion-exchange membrane Subject RIV: CD - Macromolecular Chemistry Impact factor: 0.917, year: 2006

  9. Asian Student Depression in American High Schools: Differences in Risk Factors

    Science.gov (United States)

    Song, Suzan J.; Ziegler, Robert; Arsenault, Lisa; Fried, Lise E.; Hacker, Karen

    2011-01-01

    There are inconsistent findings about depression in Asians. This study examined risk factors for depression in Asian and Caucasian adolescents. Stratified bivariate secondary analyses of risk indicators and depressed mood were performed in this cross-sectional study of high school survey data (9th to 12th grades) from 2,542 students (198 Asian).…

  10. Plasma connective tissue growth factor is an independent predictor of end-stage renal disease and mortality in type 1 diabetic nephropathy.

    NARCIS (Netherlands)

    Nguyen, T.Q.; Tarnow, L.; Jorsal, A.; Oliver, N.; Roestenberg, P.M.H.; Ito, Y.; Parving, H.H.; Rossing, P.; Nieuwenhoven, FA van; Goldschmeding, R.

    2008-01-01

    OBJECTIVE: We evaluated the predictive value of baseline plasma connective tissue growth factor (CTGF) in a prospective study of patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: Subjects were 198 type 1 diabetic patients with established diabetic nephropathy and 188 type 1 diabetic patien

  11. Early life exposures and risk of atopy among Danish children

    DEFF Research Database (Denmark)

    Thomsen, SF; Ulrik, Charlotte Suppli; Porsbjerg, C;

    2006-01-01

    . Skin test reactivity to 10 common aeroallergens was measured using standard techniques. Atopic disease was defined as a history of hayfever and/or asthma concomitantly with a positive skin-prick test. Logistic regression showed that parental atopy (odds ratio [OR] = 1.98; 95% confidence interval [CI...

  12. Drawing students' attention to relevant assessment criteria: effects on self-assessment skills and performance

    OpenAIRE

    Fastré, Greet; van der Klink, Marcel; Sluijsmans, Dominique; Van Merriënboer, Jeroen

    2012-01-01

    Fastré, G. M. J., Van der Klink, M. R., Sluijsmans, D., & Van Merriënboer, J. J. G. (2012). Drawing students’ attention to relevant assessment criteria: effects on self-assessment skills and performance. Journal of Vocational Education & Training, 64(2), 185-198. doi:10.1080/13636820.2011.630537

  13. Reduced chemical kinetic mechanisms for NOx emission prediction in biomass combustion

    DEFF Research Database (Denmark)

    Houshfar, Ehsan; Skreiberg, Øyvind; Glarborg, Peter;

    2012-01-01

    reactions and chemical species, that is, 35 species and 198 reactions, corresponding to 72% reduction in the number of reactions and, therefore, improving the computational time considerably. Yet, the model based on the reduced mechanism predicts correctly concentrations of NOx and CO that are essentially...... parameters on NOx emission. © 2012 Wiley Periodicals, Inc. Int J Chem Kinet 44: 219–231, 2012...

  14. Finite groups whose non-linear irreducible characters of the same degree are Galois conjugate

    OpenAIRE

    Dolfi, Silvio; Yadav, Manoj K.

    2016-01-01

    We classify the finite groups whose non-linear irreducible characters that are not conjugate under the natural Galois action have distinct degrees, therefore extending the results in Berkovich et al. [Proc. Amer. Math. Soc. {\\bf 115} (1992), 955-959] and Dolfi et al. [Israel J. Math. {\\bf 198} (2013), 283-331].

  15. 78 FR 54417 - Oil and Gas and Sulphur Operations on the Outer Continental Shelf-Oil and Gas Production Safety...

    Science.gov (United States)

    2013-09-04

    ... leakage. You must test according to API RP 14H (incorporated by reference as specified in Sec. 250.198... Fahrenheit for a Class I flammable liquid as described in API RP 500 and 505 (both incorporated by reference... accordance with API RP 14E, Recommended Practice for Design and Installation of Offshore Production...

  16. 30 CFR 250.1630 - Safety-system testing and records.

    Science.gov (United States)

    2010-07-01

    ...-system testing and records. (a) Inspection and testing. You must inspect and successfully test safety.... Testing must be in accordance with API RP 14C, Appendix D (incorporated by reference as specified in § 250.198). For safety system devices other than those listed in API RP 14C, Appendix D, you must...

  17. 30 CFR 250.908 - What are the minimum structural fatigue design requirements?

    Science.gov (United States)

    2010-07-01

    ... Platform Approval Program § 250.908 What are the minimum structural fatigue design requirements? (a) API RP 2A-WSD, Recommended Practice for Planning, Designing and Constructing Fixed Offshore Platforms (incorporated by reference as specified in 30 CFR 250.198), requires that the design fatigue life of each...

  18. 30 CFR 250.114 - How must I install and operate electrical equipment?

    Science.gov (United States)

    2010-07-01

    .... (a) You must classify all areas according to API RP 500, Recommended Practice for Classification of... Division 2, or API RP 505, Recommended Practice for Classification of Locations for Electrical... (incorporated by reference as specified in § 250.198), or API RP 14FZ, Recommended Practice for Design...

  19. 30 CFR 250.108 - What requirements must I follow for cranes and other material-handling equipment?

    Science.gov (United States)

    2010-07-01

    ... Petroleum Institute's Recommended Practice for Operation and Maintenance of Offshore Cranes (API RP 2D... for Offshore Pedestal Mounted Cranes (API Spec 2C), incorporated by reference as specified in 30 CFR... meet the requirements of API Spec 2C, incorporated by reference as specified in 30 CFR 250.198. (e)...

  20. Dicty_cDB: Contig-U16097-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available none) Danio rerio mRNA for calcium/calmo... 198 2e-57 BC120285_1( BC120285 |pid:none) Bos taurus pregnancy u...yvqvkkvmilg*qild*vkylemvii*khvvvvhqnm*hqkf*nvnhtikhviygvlv lspmfy*lvvshfgirimlyfmrklem*tygwpeglevsneakdlvshl...gafsivreatsratgtkvaiksintrfiknkllmreieimkkvgdhpnilklyevy ettkhlhlvlelvtggelfdkivekgsyseadaskivrqivsavghlhsig...nqr iyyvqvkkvmilg*qild*vkylemvii*khvvvvhqnm*hqkf*nvnhtikhviygvlv lspmfy*lvvshfgirimlyfmrklem*tygwpeglevsneak

  1. Novel X-Linked Genes Revealed by Quantitative Polymerase Chain Reaction in the Green Anole, Anolis carolinensis

    Czech Academy of Sciences Publication Activity Database

    Rovatsos, M.; Altmanová, M.; Johnson Pokorná, Martina; Kratochvíl, L.

    2014-01-01

    Roč. 4, č. 11 (2014), s. 2107-2113. ISSN 2160-1836 R&D Projects: GA ČR GAP506/10/0718 Institutional support: RVO:67985904 Keywords : gene dosage * lizard * qPCR Subject RIV: EG - Zoology Impact factor: 3.198, year: 2014

  2. Empathy, Self-Reflection, and Curriculum Choice

    Science.gov (United States)

    Grosseman, Suely; Hojat, Mohammadreza; Duke, Pamela M.; Mennin, Stewart; Rosenzweig, Steven; Novack, Dennis

    2014-01-01

    We administered the Jefferson Scale of Empathy and the Groningen Reflection Ability Scale to 61 of 64 entering medical students who self-selected a problem-based learning curricular track and to 163 of 198 who self-selected a lecture-based track (response rates of 95.3% and 82.3%, respectively, with no statistically significant differences in mean…

  3. AcEST: BP913315 [AcEST

    Lifescience Database Archive (English)

    Full Text Available rotein C1orf198 OS=Homo s... 30 6.7 sp|P03123|VE2_PAPVD Probable regulatory protein E2 OS=Deer papil... 29 8...21 GEKVLPP 227 >sp|P03123|VE2_PAPVD Probable regulatory protein E2 OS=Deer papillomavirus GN=E2 PE=3 SV=2 Le

  4. Drug: D09625 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D09625 Drug Gosogliptin (USAN/INN) C17H24F2N6O 366.198 366.4089 D09625.gif Treatment of diabetes ... ] [KO:K01278] hsa04974(1803) Protein digestion and absorption ... Target-based classification of drugs [BR:br08310] ...

  5. Dicty_cDB: Contig-U12119-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available R380951_196( CR380951 |pid:none) Candida glabrata strain CBS138 c... 45 0.003 CP000592_300( CP000592 |pid:none) Ostreococcus lucima...kekv*kkkkmklkrlikclnli*elimfsfhcivnvliwll kstltvfvhmkkhhkvilv*vnsnhlvimvk*cylkmvnnvgvvqnvhlkslwnvvkimn ymmyk...atattgttgaacaaccagaaattcaaacatntgaacttttanatgcaatt 197 |||||||||||||||||||||||||||||||||||||||||||||||||||||...||||||| Sbjct: 138 aatggtgaaaatattgttgaacaaccagaaattcaaacatntgaacttttanatgcaatt 197 Query: 198 tctaaagatcttg...Sbjct: 187 gcttaaatntgatttaggagttaanaatgntttcattccnttgnanagtaaangntttga 246 Query

  6. 76 FR 75799 - General Administrative Regulations; Mutual Consent Cancellation; Food Security Act of 1985...

    Science.gov (United States)

    2011-12-05

    ... Consent Cancellation; Food Security Act of 1985, Implementation; Denial of Benefits; and Ineligibility for... Crop Insurance Act. (1) Section 1764 of the Food Security Act of 1985 (Pub. L. 99-198); (2) 21 U.S.C.... See the Notice related to 7 CFR part 3015, subpart V, published at 48 FR 29115, June 24,...

  7. Rheological and Sensory Characteristics of Yoghurt-Modified Mayonnaise

    Czech Academy of Sciences Publication Activity Database

    Štern, Petr; Pokorný, J.; Šedivá, A.; Panovská, Z.

    2008-01-01

    Roč. 26, č. 3 (2008), s. 190-198. ISSN 1212-1800 R&D Projects: GA AV ČR IAA2060404 Institutional research plan: CEZ:AV0Z20600510 Keywords : mayonnaise * rheology * sensory analysis * texture * yoghurt Subject RIV: BK - Fluid Dynamics Impact factor: 0.472, year: 2008

  8. Aqueous Redox Potentials Related to Ionization Potentials and Electron Affinities of Elements by Simple Linear Equations

    Czech Academy of Sciences Publication Activity Database

    Heyrovská, Rajalakshmi

    New Jersey : The Electrochemical Society, 2000. s. 957. ISBN 1-56677-265-6. [Meeting of the Electrochemical Society /198./. 00.10.2000, Phoenix] R&D Projects: GA AV ČR IAA440401 Institutional research plan: CEZ:A54/98:Z4-040-9-ii Subject RIV: CG - Electrochemistry

  9. A Randomized Controlled Trial Evaluation of an After-School Prosocial Behavior Program in an Area of Socioeconomic Disadvantage

    Science.gov (United States)

    O'Hare, Liam; Biggart, Andy; Kerr, Karen; Connolly, Paul

    2015-01-01

    A randomized controlled trial was used to evaluate the effects of a prosocial behavior after-school program called Mate-Tricks for 9- and 10-year-old children and their parents living in an area of significant socioeconomic disadvantage. The children were randomly assigned to an intervention (n = 220) or a control group (n = 198). Children were…

  10. Stereotype Threat Effects on African American Children in an Urban Elementary School

    Science.gov (United States)

    Wasserberg, Martin J.

    2014-01-01

    This study investigated whether a diagnostic testing condition leads to stereotype threat effects for African American children (n = 198) at an urban elementary school. Results indicated that presenting a reading test as diagnostic of abilities hindered the performance of African American children aware of racial stereotypes but not of those…

  11. Low-tech-video ehk naivistide, amatööride ja videokunstnike audiovisuaalne kunst / Raivo Kelomees

    Index Scriptorium Estoniae

    Kelomees, Raivo, 1960-

    2001-01-01

    Varajasest videokunstist ja videokunstist muutunud kontekstis. Vene kunstniku Oleg Mavromatti videotest "Võbljadki" ja "Roheline elevandike". Rael Arteli, Valdek Alberi, Kristin Kalamehe ja Allan Tõnissoo töödest. Trash-videost. Marko Siguse videotest-filmidest. Taave Tuutma, Mari Sobolevi, Hanno Soansi ja Katrin Kivimaa planeeritud aktsioonide dokumentatsioonidest. Ilmunud ka kogumikus "Ekraan kui membraan". Tartu, 2007, lk. 195-198

  12. Catalytic N 2O decomposition on Pr 0.8Ba 0.2MnO 3 type perovskite catalyst for industrial emission control

    Czech Academy of Sciences Publication Activity Database

    Kumar, S.; Vinu, A.; Šubrt, Jan; Bakardjieva, Snejana; Rayalu, S.; Teraoka, Y.; Labhsetwar, N.

    2012-01-01

    Roč. 198, 1-SI (2012), s. 125-132. ISSN 0920-5861 R&D Projects: GA MŠk LC523 Institutional support: RVO:61388980 Keywords : Ba substituted perovskite * catalyst * honeycomb * N 2O decomposition * perovskite * praseodymium manganate Subject RIV: CA - Inorganic Chemistry Impact factor: 2.980, year: 2012

  13. Archeozoological analysis of finds from an excavation of the town fortification moat (?) in Šumperk

    Czech Academy of Sciences Publication Activity Database

    Nývltová Fišáková, Miriam

    Vol. 3. Praha : Archaia, 2009, s. 195-198. ISBN 978-80-904408-0-7. [Forum Archaeologiae Post-Mediaevalis. Praha (CZ), 08.04.2008-09.04.2008] Institutional research plan: CEZ:AV0Z80010507 Keywords : vertebrate * Mediaval Age * Šumperk Subject RIV: AC - Archeology, Anthropology, Ethnology

  14. Tetracycline-inducible gene expression system in Leishmania mexicana

    Czech Academy of Sciences Publication Activity Database

    Kraeva, N.; Ishemgulova, A.; Lukeš, Julius; Yurchenko, Vyacheslav

    2014-01-01

    Roč. 198, č. 1 (2014), s. 11-13. ISSN 0166-6851 R&D Projects: GA MŠk(CZ) EE2.3.30.0032 Institutional support: RVO:60077344 Keywords : Leishmania mexicana * Gene expression * Tet-inducible system Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.787, year: 2014

  15. Joint location and source mechanism inversion of microseismic events: benchmarking on seismicity induced by hydraulic fracturing

    Czech Academy of Sciences Publication Activity Database

    Anikiev, D.; Valenta, Jan; Staněk, František; Eisner, Leo

    2014-01-01

    Roč. 198, č. 1 (2014), s. 249-258. ISSN 0956-540X R&D Projects: GA ČR GAP210/12/2451 Institutional support: RVO:67985891 Keywords : inverse theory * probability distributions * wave scattering and diffraction * fractures and faults Subject RIV: DB - Geology ; Mineralogy Impact factor: 2.724, year: 2013

  16. The Prevalence and Determinants of Overweight and Obesity among French Youths and Adults with Intellectual Disabilities Attending Special Education Schools

    Science.gov (United States)

    Begarie, Jerome; Maiano, Christophe; Leconte, Pascale; Ninot, Gregory

    2013-01-01

    This study examines the prevalence of overweight and obesity and a panel of potential determinants among French youths and adults with an intellectual disability (ID). The sample used consisted of 1120 youths and adults with an ID, from 5 to 28 years old, attending a French special education school. The results indicated that 19.8% of the…

  17. Technological Foresight and Technology Assessment. Methods for Enabling Innovations in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Machleidt, Petr

    Karlsruhe: Impressum - KIT, 2011 - (Banse, G.; Grunwald, A.; Hronszky, I.; Nelson, G.), s. 195-198 ISBN 978-3-86644-731-8 Institutional research plan: CEZ:AV0Z90090514 Keywords : society * public * science and technology * promotion of innovations Subject RIV: AA - Philosophy ; Religion

  18. Magnetic properties of ion beam mixed and annealed Ag/Fe/Ag-(001)-layers

    Czech Academy of Sciences Publication Activity Database

    Kurowski, D.; Brand, K.; Pelzl, J.; Frait, Zdeněk

    198/199, - (1999), s. 360-362. ISSN 0304-8853. [MML`98. Vancouver, 00.00.1998] Institutional research plan: CEZ:AV0Z1010914 Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.195, year: 1999

  19. The Gendered Consequences of Unemployment Insurance Reforms

    NARCIS (Netherlands)

    Mooi-Reci, Irma; Mills, Melinda

    2012-01-01

    This study examines whether a series of unemployment insurance benefit reforms that took place over a 20-year period in the Netherlands had a gendered effect on the duration of unemployment and labor market outcomes. Using longitudinal data from the Dutch Labor Supply Panel (OSA) over the period 198

  20. Investigation of University Students' Self-Acceptance and Learned Resourcefulness: A Longitudinal Study

    Science.gov (United States)

    Ceyhan, A. Aykut; Ceyhan, Esra

    2011-01-01

    Self-acceptance and learned resourcefulness of university students are important concepts in coping with the environmental and developmental stressors and in the development of healthy personality. In this study, university students' self acceptance and learned resourcefulness levels were investigated longitudinally. 198 university students' self…

  1. AcEST: BP912264 [AcEST

    Lifescience Database Archive (English)

    Full Text Available KGDALLFFSLHPSAVPDESSLHTGCPVIEGEKWSATKWIHVAAFEKPRPKNGACV 224 Query: 195 DEDESCGEWAAYGECQKNPTYMIGTSEQPGY 287 +...HGGCPVIEGEKWSATKWIHV S D G+C Sbjct: 200 AVKPRKGDALLFFNLHPDAIPDPLSLHGGCPVIEGEKWSATKWIHVDSFDRIVTPSGNCT 259 Query: 195 DEDESCG...GDALLFFNLHPDAIPDPLSLHGGCPVIEGEKWSATKWIHVDSFDRIVTPSGNCT 259 Query: 195 DEDESCGEWAAYGECQKNPTYMIGTSEQPGY 287 D ...HGGCPVIEGEKWSATKWIHVDSFDKILKPGGNCT 259 Query: 195 DEDESCGEWAAYGECQKNPTYMIGTSEQPG 284 DE++SC WAA GEC KNP YM+G...GDALLFYSLHPNATPDPLSLHGGCPVIQGEKWSATKWIHVDSFDKTVDTEGNCSD 256 Query: 198 EDESCGEWAAYGECQKNPTYMIGTSEQPGY 287 DE

  2. 40 CFR 98.368 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Table JJ-3 See Table JJ-3 0.33 Market Swine 180 lbs 91 5.40 0.42 0.48 Breeding Swine 198 2.60 0.24 0.48... removal (decimal) Gravity 0.60 0.60 Mechanical: Stationary Screen 0.20 0.10 Vibrating Screen 0.15...

  3. Children's Moral Self-Concept: The Role of Aggression and Parent-Child Relationships

    Science.gov (United States)

    Sengsavang, Sonia; Krettenauer, Tobias

    2015-01-01

    This study examined the role of aggressiveness and parenting in the development of children's moral self-concept. Participants were 198 elementary school children and their parents (M = 8.65 years, SD = 2.44). Participants completed a structured moral self puppet interview and a questionnaire about their relationship to parents. Parents completed…

  4. Gclust Server: 201657 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 201657 OSA_Os06g0101000 Cluster Sequences - 198 no annotation 1 1.00e-99 14.29 0.0 0.0 0.0 0.0 0.0 Show 2016...57 Cluster ID 201657 Sequence ID OSA_Os06g0101000 Link to cluster sequences Cluster

  5. A Unifying Framework for the Problem of Adjudicating Conflicting Claims

    DEFF Research Database (Denmark)

    Hougaard, Jens Leth; Moreno-Ternero, Juan D.; Østerdal, Lars Peter Raahave

    In a recent paper, Thomson and Yeh [Operators for the adjudication of conflicting claims, Journal of Economic Theory 143 (2008) 177-198] introduced the concept of operators on the space of rules for the problem of adjudicating conflicting claims. They focussed on three operators in order to uncov...

  6. EST Table: FY019155 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY019155 rbmov24f18 11/11/04 50 %/198 aa ref|XP_974629.1| PREDICTED: similar to alpha methylacyl ... 31 %/165 aa C24A3.4#CE40019#WBGene00016034#E. coli L-carnitine ... dehydratase#status:Partially_confirmed#UniProt:Q18 ...

  7. A β - γ coincidence

    International Nuclear Information System (INIS)

    A β - γ coincidence method for absolute counting is given. The fundamental principles are revised and the experimental part is detailed. The results from 198 Au irradiated in the JEN 1 Swimming pool reactor are given. The maximal accuracy is 1 per cent. (Author) 11 refs

  8. Effects of sweeteners on individual feed intake characteristics and performance in group-housed weanling pigs

    NARCIS (Netherlands)

    Sterk, A.R.; Schlegel, P.; Mul, A.J.; Ubbink-Blanksma, M.; Bruininx, E.M.A.M.

    2008-01-01

    To assess the effects of 2 high intensity sodium saccharine based sweeteners on individual feed intake characteristics and performance of group-housed weaned pigs, 198 26-d-old weanling pigs were given ad libitum access to 3 dietary treatments: containing no additional sweetener (Control), 150 mg sw

  9. Deciphering effects of functional groups and electron density on azo dyes degradation by graphene loaded TiO2

    Science.gov (United States)

    Zhang, Qian; Liang, Xiao; Chen, Bor-Yann; Chang, Chang-Tang

    2015-12-01

    This study tended to decipher the mechanism of photo degradation of azo dyes, which bond was favorable to be broken for application of wastewater decolorization. That is, from chemical structure perspective, the critical substituents to affect electron donor/acceptor for dye degradation would be identified in this research. The model reactive blacks (RB5), reactive blue 171 (RB171) and reactive red 198 (RR198) were degraded by graphene loaded TiO2, indicating how the electron withdrawing and releasing groups affect azo dye degradability. The byproducts and intermediate products were analyzed by ultraviolet-visible spectroscopy (UV-vis), gas chromatography-mass spectrometry (GC-MS) and ion chromatography (IC). Furthermore, the radicals involved in the reaction were found by electron paramagnetic resonance (ESR) to confirm the main oxidized species of hydroxyl radicals rather than the light generated positive holes. The finding revealed that the breakages of the bonds were due to the electron density changes around the bonds. This principle can be applicable not only for RB5 degradation, but also for reactive blue 171 (RB171), reactive red 198 (RR198) and some other textile dyes.

  10. Nedestruktivní hodnocení a monitorování ocelových a betonových stavebních konstrukcí

    Czech Academy of Sciences Publication Activity Database

    Převorovský, Zdeněk; Kober, Jan; Krofta, Josef; Chlada, Milan

    2013-01-01

    Roč. 23, 1-2 (2013), s. 24-29. ISSN 1213-3825 R&D Projects: GA MPO(CZ) FR-TI1/198 Institutional support: RVO:61388998 Keywords : structural health monitoring * civil structures * nonlinear elastic wave spectroscopy * acoustic emission Subject RIV: JN - Civil Engineering

  11. Psychoanalysis and Bible

    OpenAIRE

    Vandermeersch, Patrick

    2001-01-01

    Here you find the introductory and the final chapter, written by P. Vandermeersch, in R. KESSLER & P. VANDERMEERSCH (eds.), God, Biblical Stories and Psychoanalytical Understanding, Frankfurt a. M., Peter Lang, 2001: `Psychoanalytic Interpretations of Religious Texts. Some Basics' (9-27) en `Looking Back at Sodom. Psychoanalysis and Diachronic Reading' (187-198).

  12. Investigation of mercury-containing proteins by enriched stable isotopic tracer and size-exclusion chromatography hyphenated to inductively coupled plasma-isotope dilution mass spectrometry

    International Nuclear Information System (INIS)

    In order to investigate trace mercury-containing proteins in maternal rat and their offspring, a method of enriched stable isotopic tracer (196Hg and 198Hg) combined with size-exclusion chromatography (SEC) coupled to inductively coupled plasma-isotope dilution mass spectrometry (ICP-IDMS) was developed. Prior to the analysis, 196Hg- and 198Hg-enriched methylmercury was administrated to the pregnant rats. Then the mercury-containing proteins in serum and brain cytosol of the dam and pup rats were separated by size-exclusion columns and the mercury was detected by ICP-MS. The ICP-MS spectrogram of the tracing samples showed significantly elevated 196Hg and 198Hg isotopic signals compared with the natural ones, indicating that the detection sensitivity could be increased by the tracer method. The contents of mercury in chromatographic fractions of the dam and pup rat brain cytosol were quantitatively estimated by post-column reverse ID-ICP-MS. The quantitative speciation differences of mercury in brain cytosol between the dam and pup rats were observed, indicating that such studies could be useful for toxicological estimation. Additionally, the isotopic ratio measurement of 198Hg/202Hg in the tracing samples could be used to identify the artifact mercury species caused in the analytical procedure. The study demonstrates that the tracer method combined with high-performance liquid chromatography (HPLC)-ICP-IDMS could provide reliably qualitative and quantitative information on mercury-containing proteins in organisms

  13. Decolorization of different textile dyes by Penicillium simplicissimum and toxicity evaluation after fungal treatment

    Directory of Open Access Journals (Sweden)

    L.R. Bergsten-Torralba

    2009-12-01

    Full Text Available The objective of this study was to investigate the capacity of decolorization and detoxification of the textile dyes Reactive Red 198 (RR198, Reactive Blue 214 (RB214, Reactive Blue 21 (RB21 and the mixture of the three dyes (MXD by Penicillium simplicissimum INCQS 40211. The dye RB21, a phthalocyanine, was totally decolorized in 2 days, and the others, the monoazo RR198, the diazo RB214 and MXD were decolorized after 7 days by P. simplicissimum. Initially the dye decolorization involved dye adsorption by the biomass followed by degradation. The acute toxicity after fungal treatment was monitored with the microcrustacean Daphnia pulex and measured through Effective Concentration 50% (EC50. P. simplicissimum reduced efficiently the toxicity of RB21 from moderately acutely toxic to minor acutely toxic and it also reduced the toxicity of RB214 and MXD, which remained minor acutely toxic. Nevertheless, the fungus increased the toxicity of RR198 despite of the reduction of MXD toxicity, which included this dye. Thus, P. simplicissimum INCQS 40211 was efficient to decolorize different textile dyes and the mixture of them with a significant reduction of their toxicity. In addition this investigation also demonstrated the need of toxicological assays associated to decolorization experiments.

  14. Selectivity of Nanocrystalline IrO2-Based Catalysts in Parallel Chlorine and Oxygen Evolution

    Czech Academy of Sciences Publication Activity Database

    Kuznetsova, Elizaveta; Petrykin, Valery; Sunde, S.; Krtil, Petr

    2015-01-01

    Roč. 6, č. 2 (2015), s. 198-210. ISSN 1868-2529 EU Projects: European Commission(XE) 214936 Institutional support: RVO:61388955 Keywords : iridium dioxide * oxygen evolution * chlorine evolution Subject RIV: CG - Electrochemistry Impact factor: 2.367, year: 2014

  15. Fe speciation and Fe/Al ratio in the sediments of southeastern Arabian Sea as an indicator of climate change

    Digital Repository Service at National Institute of Oceanography (India)

    Pattan, J.N.; Parthiban, G.; Gupta, S.M.; Mir, I.A.

    .98%), carbonate (1.98%), Fe–Mn oxide (30.8%), organic carbon (4.7%) and biogenic opal (11.4%) which together constitutes nearly 50% of the bulk Fe content. There is a good correlation between time series Fe/Al and differential solar insolation, suggesting warmer...

  16. Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis

    Czech Academy of Sciences Publication Activity Database

    Andrysík, Zdeněk; Machala, M.; Chramostová, Kateřina; Hofmanová, Jiřina; Kozubík, Alois; Vondráček, Jan

    2006-01-01

    Roč. 211, č. 3 (2006), s. 198-208. ISSN 0041-008X R&D Projects: GA ČR(CZ) GP525/01/D076 Institutional research plan: CEZ:AV0Z50040507 Keywords : MAP kinases * PAHs * apoptosis Subject RIV: BO - Biophysics Impact factor: 4.722, year: 2006

  17. Bagately o knižních rozhovorech, samuraji Vajchrovi, Mojmíru Trávníčkovi a básnických dvojčatech Violy Fischerové

    Czech Academy of Sciences Publication Activity Database

    Zizler, Jiří

    2008-01-01

    Roč. 19, č. 1 (2008), s. 198-202. ISSN 0862-6928 Institutional research plan: CEZ:AV0Z90560517 Keywords : Trávníček, Mojmír * Czech Literature * Fischerová, Viola Subject RIV: AJ - Letters, Mass-media, Audiovision

  18. Age at Onset of Epilepsy and Effect of Uncontrolled Seizures on Cognitive Outcome

    OpenAIRE

    J Gordon Millichap

    2012-01-01

    Researchers at the Epilepsy Center and Department of Psychiatry at Lurie Children’s Hospital of Chicago examined the association of cognitive scores and age at onset of epilepsy, pharmacoresistance, and interaction between the two in a prospective community-based study of 198 children, aged

  19. Bemerkungen zur Idee der Ganzheitlichkeit bei Comenius

    Czech Academy of Sciences Publication Activity Database

    Schifferová, Věra

    Wiesbaden: Springer VS, 2016 - (Goris, W.; Meyer, M.; Urbánek, V.), s. 189-198 ISBN 978-3-658-08260-4 R&D Projects: GA ČR GA13-08740S Institutional support: RVO:67985955 Keywords : Comenius * Patočka * the idea of the whole Subject RIV: AA - Philosophy ; Religion

  20. 48 CFR 242.002 - Interagency agreements.

    Science.gov (United States)

    2010-10-01

    .../Chief Financial Officer), from non-DoD organizations, except for— (A) Quality assurance, contract... subcontracts awarded by the Small Business Administration under FAR subpart 19.8; and (C) Quality assurance and..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES 242.002...

  1. On the radical scavenging activity of isoflavones: thermodynamics of O–H bond cleavage

    Czech Academy of Sciences Publication Activity Database

    Lengyel, Jozef; Rimarčík, J.; Vagánek, A.; Klein, E.

    2013-01-01

    Roč. 15, č. 26 (2013), s. 10895-10903. ISSN 1463-9076 R&D Projects: GA ČR GA203/09/0422 Institutional support: RVO:61388955 Keywords : LOSS ELECTRON-TRANSFER * DISSOCIATION ENTHALPIES * ANTIOXIDANT PROPERTIES Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 4.198, year: 2013

  2. Tight-binding Study of Ammonia and Hydrogen Adsorption on Magnetic Cobalt Systems

    Czech Academy of Sciences Publication Activity Database

    Pick, Štěpán; Dreyssé, H.

    2000-01-01

    Roč. 460, 1/3 (2000), s. 153-161. ISSN 0039-6028 R&D Projects: GA AV ČR KSK2040602 Institutional research plan: CEZ:AV0Z4040901 Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.198, year: 2000

  3. Event-Driven Interoperability Framework For Interoperation In E-Learning Information Systems - Monitored Repository

    NARCIS (Netherlands)

    Petrov, Milen

    2006-01-01

    M.Petrov "Event-Driven Interoperability Framework For Interoperation In E-Learning Information Systems - Monitored Repository", IADAT-e2006, 3rd International Conference on Education, Barcelona (Spain), July 12-14, 2006, ISBN: 84-933971-9-9, pp.198 - pp.202

  4. AcEST: DK963176 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TST39A01NGRL0015_N07 592 Adiantum capillus-veneris mRNA. clone: TST39A01NGRL0015_N07. 5' end seq ... |Q6DW15_9CARY Tonoplast intrinsic protein gamma OS=Salicornia ... herbacea PE=2 SV=2 Length = 254 Score = 198 bits ( ...

  5. AcEST: DK959401 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TST39A01NGRL0004_J12 644 Adiantum capillus-veneris mRNA. clone: TST39A01NGRL0004_J12. 5' end seq ... 0|Q1W2L0_SALBI Putative CPF 0172 family protein OS=Salicornia ... bigelovii GN=UPF1 PE=2 SV=1 Length = 198 Score = 1 ...

  6. AcEST: DK951930 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TST38A01NGRL0012_L15 654 Adiantum capillus-veneris mRNA. clone: TST38A01NGRL0012_L15. 5' end seq ... 0|Q1W2L0_SALBI Putative CPF 0172 family protein OS=Salicornia ... bigelovii GN=UPF1 PE=2 SV=1 Length = 198 Score = 1 ...

  7. Illicit Drug Use, Cigarette Smoking and Alcohol Drinking Behaviour among a Sample of High School Adolescents in the Pietersburg Area of the Northern Province, South Africa.

    Science.gov (United States)

    Madu, Sylvester Ntomchukwu; Matla, Ma-Queen Patience

    2003-01-01

    Investigates the prevalence of illicit drug use, cigarette smoking and alcohol drinking behavior among a sample of high-school adolescents in the Pietersburg area of South Africa. Findings indicate the prevalence rate of 19.8% for illicit drug use, 10.6% for cigarette smoking and 39.1% for alcohol consumption among the participants. Implications…

  8. Cutaneous leishmaniasis with lymphadenopathy due to Leishmania donovani

    Czech Academy of Sciences Publication Activity Database

    Faber, W. R.; Wonders, J.; Jensema, A. J.; Chocholová, Eva; Kager, P. A.

    2009-01-01

    Roč. 34, č. 5 (2009), E196-E198. ISSN 0307-6938 Institutional research plan: CEZ:AV0Z60220518 Keywords : LYMPH-NODE INVOLVEMENT * BRAZILIENSIS * INFECTION Subject RIV: FN - Epidemiology, Contagious Diseases ; Clinical Immunology Impact factor: 1.550, year: 2009

  9. Prospective Relations between Organized Activity Participation and Psychopathology during Adolescence

    Science.gov (United States)

    Bohnert, Amy M.; Garber, Judy

    2007-01-01

    This longitudinal study examined psychopathology as a predictor and outcome of organized activity involvement during high school among 198 adolescents who varied in risk for psychopathology as a function of their mother's depression history. Higher levels of internalizing and externalizing symptoms in eighth grade significantly predicted lower…

  10. K voprosu o sravnenii nacional-socializma i stalinizma i razvitije interpretacionnych modelej diktatur XX veka

    Czech Academy of Sciences Publication Activity Database

    Voráček, Emil

    Moskva: Institut Slavjanovedenija RAN, 2008, s. 198-218. ISBN 978-5-7575-0226-8 R&D Projects: GA AV ČR(CZ) IAA800150603 Institutional research plan: CEZ:AV0Z80150510 Keywords : national socialism * stalinism * bolshevism Subject RIV: AB - History

  11. Liberomyces gen. nov with two new species of endophytic coelomycetes from broadleaf trees

    Czech Academy of Sciences Publication Activity Database

    Pažoutová, Sylvie; Šrůtka, P.; Holuša, J.; Chudíčková, Milada; Kubátová, A.; Kolařík, Miroslav

    2012-01-01

    Roč. 104, č. 1 (2012), s. 198-210. ISSN 0027-5514 R&D Projects: GA ČR GA206/07/0283 Institutional research plan: CEZ:AV0Z50200510 Keywords : anamorph * alnus * phylogeny Subject RIV: EE - Microbiology, Virology Impact factor: 2.110, year: 2012

  12. Musica mediaeva liturgica

    Czech Academy of Sciences Publication Activity Database

    Vozková, Jana

    2010-01-01

    Roč. 47, 2-3 (2010), s. 198-199. ISSN 0018-7003. [ Musica mediaeva liturgica. Ružomberok, 04.05.2010-05.05.2010] Institutional research plan: CEZ:AV0Z90580513 Keywords : music * liturgy * international conference Subject RIV: AL - Art, Architecture, Cultural Heritage

  13. Determination of gold in some Myanmar indigenous medicines by neutron activation analysis

    International Nuclear Information System (INIS)

    Gold has been determined in two Myanmar indigenous medicines TMF 14 (Devaauthada), TMF 15 (Shwe Thwe Say) by neutron activation analysis using an Am(Be) radionuclide neutron source. The activity of 411 keV of the 198Au has been measured. (author). 2 refs., 1 fig., 1 tab

  14. Is the treatment effect of IFN-beta restored after the disappearance of neutralizing antibodies?

    DEFF Research Database (Denmark)

    Sorensen, P S; Koch-Henriksen, Nils; Flachs, Esben Meulengracht; Bendtzen, K

    2008-01-01

    comparing the NAb-positive with the NAb-negative periods was 1.98 (95% confidence interval: 1.32-2.97). CONCLUSION: Under NAb-positive periods, the clinical effect of IFN-beta was abolished. When NAbs disappeared spontaneously under continued treatment, patients regained the full effect of INF-beta-1b...

  15. 77 FR 17564 - Notice of Final Federal Agency Actions on Proposed Highway in Utah

    Science.gov (United States)

    2012-03-26

    ... of Utah: Cottonwood Street; 4500 South to Vine Street in Murray City, Salt Lake County, project number S-LC35(198). The project will be a one-way couplet with southbound traffic on Box Elder Street and... proposed transportation corridor project (Cottonwood Street; 4500 South to Vine Street in Murray City,...

  16. High-dose 5-fluorouracil plus low dose methotrexate plus or minus low-dose PALA in advanced colorectal cancer : a randomised phase II-III trial of the EORTC Gastrointestinal Group

    NARCIS (Netherlands)

    Wils, J; Blijham, GH; Wagener, T; De Greve, J; Jansen, RLH; Kok, TC; Nortier, JWR; Bleiberg, H; Couvreur, ML; Genicot, B; Baron, B

    2003-01-01

    The aim of this study was to investigate whether N-(phosphonacetyl)-L-aspartic acid (PALA) can enhance the activity of low-dose methotrexate (LD-MTX) modulated infusional 5-fluorouracil (5-FU) in patients with advanced colorectal cancer. 198 patients were randomised either to (i) 5-FU 60 mg/kg as a

  17. Canadian Youths' Trajectories of Psychosocial Competencies through University: Academic and Romantic Affairs Matter

    Science.gov (United States)

    Lascano, Dayuma Ixchel Vargas; Galambos, Nancy L.; Hoglund, Wendy L.

    2014-01-01

    The increasingly prolonged transition to adulthood has raised concerns about the nature and timing of growth in the attainment of important psychosocial competencies in young people. Changes over time in self-reported competencies (work orientation, identity, intimacy) were examined in 198 Canadians, who were followed for the first 4 years of…

  18. NMR study of thermosensitive homopolymers and copolymers in aqueous solutions

    Czech Academy of Sciences Publication Activity Database

    Spěváček, Jiří; Šťastná, J.; Starovoytova, Larisa; Hanyková, L.

    Ireland : University College Dublin, 2012. s. 198. [EUROMAR 2012. Magnetic Resonance Conference. 01.07.2012-05.07.2012, Dublin] R&D Projects: GA ČR GA202/09/1281 Institutional research plan: CEZ:AV0Z40500505 Institutional support: RVO:61389013 Keywords : thermosensitive polymer * aqueous solution * phase transition Subject RIV: CD - Macromolecular Chemistry

  19. Directly-Modulated VCSELs for 2x2 MIMO-OFDM Radio over Fiber in WDM-PON

    DEFF Research Database (Denmark)

    Binti Othman, Maisara; Deng, Lei; Pang, Xiaodan; Caminos, Josu; Kozuch, Wojciech Tomasz; Prince, Kamau; Jensen, Jesper Bevensee; Tafur Monroy, Idelfonso

    2011-01-01

    We demonstrate directly- modulated VCSELs supporting 2x2 MIMO-OFDM 5.6-GHz radio over fiber signaling over 20-km WDM-PON. Error-free signal demodulation of 64-subcarrier 4-QAM signals modulated at 198.5-Mb/s is achieved after fiber and 2-m indoor wireless transmission....

  20. Directly-Modulated VCSELs for 2x2 MIMO-OFDM Radio over Fiber in WDM-PON

    OpenAIRE

    Binti Othman, Maisara; Deng, Lei; Pang, Xiaodan; Caminos, Josu; Kozuch, Wojciech Tomasz; Prince, Kamau; Jensen, Jesper Bevensee; Tafur Monroy, Idelfonso

    2011-01-01

    We demonstrate directly- modulated VCSELs supporting 2x2 MIMO-OFDM 5.6-GHz radio over fiber signaling over 20-km WDM-PON. Error-free signal demodulation of 64-subcarrier 4-QAM signals modulated at 198.5-Mb/s is achieved after fiber and 2-m indoor wireless transmission.