WorldWideScience

Sample records for astatine 197

  1. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  2. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  3. Adsorption interaction of astatine species with quartz and gold surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Serov, A. [Paul Scherrer Institute, Villigen (Switzerland). Lab. for Radiochemistry and Environmental Chemistry; Bern Univ. (Switzerland). Dept. for Chemistry and Biochemistry; Aksenov, N.; Bozhikov, G. [Joint Institute for Nuclear Research, Dubna (RU). Flerov Lab. of Nuclear Reactions] (and others)

    2011-07-01

    The adsorption interaction of various astatine species with quartz and gold surfaces was investigated by gas chromatography methods. Due to variations of the redox potential of the carrier gas elemental astatine, astatine oxide and hypo-astatic acid have been produced. The identification of the astatine compounds is based on the analogy assumption to the gas phase chemistry of the closest homologues in group 17 of the periodic table, iodine and bromine. The deposition temperatures as well as enthalpies of adsorption have been determined for the astatine species. The enhancement of the metallic character within group 17 towards higher Z is clearly confirmed. Macroscopic properties (sublimation enthalpy) of previously unstudied AtO{sub 2} and HAtO were estimated. The determined data for elemental astatine were compared to available literature data. Based on the obtained experimental results possible designs of experiments for studying of chemical properties of the recently discovered element 117 can be suggested. (orig.)

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. Discovery of the astatine, radon, francium, and radium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  6. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  7. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  8. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  9. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  10. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  11. 32 CFR 197.5 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 197.5 Section 197.5 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS HISTORICAL RESEARCH IN THE FILES OF THE OFFICE OF THE SECRETARY OF DEFENSE (OSD) § 197.5 Responsibilities....

  12. 46 CFR 197.326 - Oxygen safety.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Oxygen safety. 197.326 Section 197.326 Shipping COAST... GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.326 Oxygen safety. (a) Equipment used with oxygen or oxygen mixtures greater than 40 percent by volume must be designed for such use. (b)...

  13. 46 CFR 197.420 - Operations manual.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Operations manual. 197.420 Section 197.420 Shipping... GENERAL PROVISIONS Commercial Diving Operations Operations § 197.420 Operations manual. (a) The diving supervisor shall— (1) Provide an operations manual to the person-in-charge prior to commencement of...

  14. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom;

    2015-01-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...... and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting...... vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method...

  15. 46 CFR 197.452 - Oxygen cleaning.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Oxygen cleaning. 197.452 Section 197.452 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE OCCUPATIONAL SAFETY AND HEALTH STANDARDS....452 Oxygen cleaning. The diving supervisor shall ensure that equipment used with oxygen or...

  16. 46 CFR 197.560 - Medical surveillance.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Medical surveillance. 197.560 Section 197.560 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE OCCUPATIONAL SAFETY AND HEALTH STANDARDS..., a history of blood dyscrasias including genetic hemoglobin abnormalities, bleeding...

  17. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  18. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  19. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  20. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  1. 46 CFR 197.454 - First aid and treatment equipment.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false First aid and treatment equipment. 197.454 Section 197.454 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE OCCUPATIONAL SAFETY AND... Equipment § 197.454 First aid and treatment equipment. The diving supervisor shall ensure that medical...

  2. 46 CFR 197.314 - First aid and treatment equipment.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false First aid and treatment equipment. 197.314 Section 197... HEALTH STANDARDS GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.314 First aid and... consists of— (i) Basic first aid supplies; and (ii) Any additional supplies necessary to treat minor...

  3. 46 CFR 197.344 - Inflatable floatation devices.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Inflatable floatation devices. 197.344 Section 197.344... STANDARDS GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.344 Inflatable floatation devices. An inflatable floatation device for SCUBA diving must— (a) Be capable of maintaining the diver at...

  4. 46 CFR 197.342 - Buoyancy-changing devices.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Buoyancy-changing devices. 197.342 Section 197.342... STANDARDS GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.342 Buoyancy-changing devices. (a) A dry suit or other buoyancy-changing device not directly connected to the exhaust valve of...

  5. 46 CFR 197.318 - Gages and timekeeping devices.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Gages and timekeeping devices. 197.318 Section 197.318... STANDARDS GENERAL PROVISIONS Commercial Diving Operations Equipment § 197.318 Gages and timekeeping devices... timekeeping device must be at each dive location....

  6. 46 CFR 197.458 - Gages and timekeeping devices.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Gages and timekeeping devices. 197.458 Section 197.458... § 197.458 Gages and timekeeping devices. The diving supervisor shall insure that— (a) Each depth gage and timekeeping device is tested or calibrated against a master reference gage or time-keeping...

  7. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  8. Cellular and molecular effects of cross reacting material 197 (CRM197) on HT-29 colon cancer cell line

    OpenAIRE

    Rivetti, Stefano

    2012-01-01

    Cross Reacting Material 197(CRM197) is a Diphteria toxin non toxic mutant that had shown anti-tumor activity in mice and humans. CRM197 is utilized as a specific inhibitor of heparin-binding epidermal growth factor (HB-EGF), that competes for the epidermal growth factor receptor (EGFR), overexpressed in colorectal cancer and implicated in its progression. We evaluated the effects of CRM197 on HT-29 human colon cancer cell line behaviour and, for CRM197 recognized ability to inhibit HB-EGF,...

  9. 30 CFR 19.7 - Protection against explosion hazard.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection against explosion hazard. 19.7..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC CAP LAMPS § 19.7 Protection against explosion hazard. Unless properly designed, electric cap lamps may present two sources of probable explosion...

  10. 46 CFR 197.565 - Notifying personnel of benzene hazards.

    Science.gov (United States)

    2010-10-01

    ... appendices A and B of this subpart or a MSDS on benzene meeting the requirements of 29 CFR 1910.1200(g) is... 46 Shipping 7 2010-10-01 2010-10-01 false Notifying personnel of benzene hazards. 197.565 Section... AND HEALTH STANDARDS GENERAL PROVISIONS Benzene § 197.565 Notifying personnel of benzene hazards....

  11. 46 CFR 197.462 - Pressure vessels and pressure piping.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Pressure vessels and pressure piping. 197.462 Section... Diving Equipment § 197.462 Pressure vessels and pressure piping. (a) The diving supervisor shall ensure that each pressure vessel, including each volume tank, cylinder and PVHO, and each pressure...

  12. 42 CFR 84.197 - Respirator containers; minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Respirator containers; minimum requirements. 84.197... Cartridge Respirators § 84.197 Respirator containers; minimum requirements. Respirators shall be equipped with a substantial, durable container bearing markings which show the applicant's name, the type...

  13. Identification of neutron-rich isotope 197Os

    Institute of Scientific and Technical Information of China (English)

    YANG Wei-Fan; YUAN Shuang-Gui; XU Yan-Bing; XIAO Yong-Hou; ZHAO Li-Min; WANG Ping-Zhi; LI Heng-Yuan

    2004-01-01

    A new neutron-rich isotope 197Os was produced in the 198Pt(n, 2p) reaction by irradiating natural Pt targets with 14 MeV neutrons. The γ(X) singles spectrum and coincidence spectrum measurements were performed using two HPGe γ-ray detectors. Ten unknown γ-rays at 41.2, 50.7, 196.8, 199.6, 223.9, 233.1, 250.2, 342.1,403.6, and 460.4 keV attributed to the decay of 197Os were observed in the experiments. The half-life of 197Os was found to be (2.8 ± 0.6) min. A partial decay scheme of 197Os was proposed on the basis of decay and coincidence relations. The half-life was compared with the values expected by different theoretical models.

  14. 46 CFR 197.488 - Retention of records after casualty.

    Science.gov (United States)

    2010-10-01

    ... casualty is made under § 197.484 shall retain all records onboard that are maintained on the vessel or... until advised by the Officer-in-Charge, Marine Inspection, that records need not be retained onboard....

  15. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  16. Freeze-out configuration properties in the 197Au + 197Au reaction at 23 AMeV

    CERN Document Server

    Najman, R; Sochocka, A; Amorini, F; Auditore, L; Cap, T; Cardella, G; De Filippo, E; Geraci, E; Grzeszczuk, A; Kowalski, S; Kozik, T; Lanzalone, G; Lombardo, I; Majka, Z; Nicolis, N G; Pagano, A; Piasecki, E; Pirrone, S; Politi, G; Rizzo, F; Russotto, P; Siwek-Wilczynska, K; Skwira-Chalot, I; Trifiro, A; Trimarchi, M; Wilczynski, J; Zipper, W

    2015-01-01

    Data from the experiment on the 197Au + 197Au reaction at 23 AMeV are analyzed with an aim to find signatures of exotic nuclear configurations such as toroid-shaped objects. The experimental data are compared with predictions of the ETNA code dedicated to look for such configurations and with the QMD model. A novel criterion of selecting events possibly resulting from the formation of exotic freeze-out configurations, "the efficiency factor", is tested. Comparison between experimental data and model predictions may indicate for the formation of flat/toroidal nuclear systems.

  17. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  18. 27 CFR 26.197 - Furnishing formula to consignee.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Furnishing formula to... Custody to Internal Revenue Bond § 26.197 Furnishing formula to consignee. Prior to the first shipment... formula covering such spirits to the appropriate TTB officer, and to the proprietor of each...

  19. 40 CFR 197.31 - What is a representative volume?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false What is a representative volume? 197... a representative volume? (a) It is the volume of ground water that would be withdrawn annually from... Yucca Mountain disposal system that will be in the representative volume. The DOE must then use...

  20. 40 CFR 197.4 - What standard must DOE meet?

    Science.gov (United States)

    2010-07-01

    ... Health and Environmental Standards for Storage § 197.4 What standard must DOE meet? The DOE must ensure... storage (as defined in 40 CFR 191.2) of radioactive material that: (1) Is subject to 40 CFR 191.3(a);...

  1. 40 CFR 197.30 - What standards must DOE meet?

    Science.gov (United States)

    2010-07-01

    ... Health and Environmental Standards for Disposal Ground Water Protection Standards § 197.30 What standards... representative volume of ground water to exceed the limits in the following Table 1: Table 1—Limits on... included? Combined radium-226 and radium-228 5 picocuries per liter Yes. Gross alpha activity...

  2. 49 CFR 173.197 - Regulated medical waste.

    Science.gov (United States)

    2010-10-01

    ... must be disinfected by any means effective for neutralizing the infectious substance the packaging... SHIPMENTS AND PACKAGINGS Non-bulk Packaging for Hazardous Materials Other Than Class 1 and Class 7 § 173.197... requirements of Part 178 of this subchapter at the Packing Group II performance level. A non-bulk...

  3. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  4. Investigation of 11B+197Au Reaction at Intermediate Energies

    CERN Document Server

    Karapetyan, G S; Balabekyan, A R

    2016-01-01

    Mechanism of nuclear reactions on 197Au induced by 11B ions at energies above Coulomb barrier was studied by induced-activity method and gamma-spectroscopy. The cross sections of the reaction fragments from 197Au induced by 11B ions were measured at bombarding energies 137.5 and 255.5 MeV. The fission process was investigated by using multimodal fission approach at the energy 137.5 MeV, and pure symmetric distribution at 255.5 MeV. It was observed that the transferred linear momentum provides the information on the initial projectile-target information. The fissility for both fission reactions under study was deduced from measured fission cross section using the total inelastic cross section. Comparison with proton-induced fission shown, that the linear momentum transferred to the fissile system depends on the probe.

  5. 10 CFR 431.197 - Manufacturer's determination of efficiency for distribution transformers.

    Science.gov (United States)

    2010-01-01

    ... distribution transformers. 431.197 Section 431.197 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Distribution Transformers Compliance and Enforcement § 431.197 Manufacturer's determination of efficiency for distribution transformers. When...

  6. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  7. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  8. Theranostic mercury: 197(m)Hg with high specific activity for imaging and therapy

    International Nuclear Information System (INIS)

    The no carrier added (NCA) radionuclide 197(m)Hg is accessible through proton induced nuclear reactions on gold. The decay properties of both simultaneous produced nuclear isomers 197mHg and 197Hg like convenient half life, low energy gamma radiations for imaging, Auger and conversion electrons for therapy are combined with unique chemical and physical properties of mercury and its compounds. Gold as a monoisotopic element has a natural abundance of 100% 197Au superseding expensive enrichment for the target material. Additionally, the high thermal conductivity of gold enables high beam current irradiations. For separation of target material a liquid–liquid extraction method was applied. - Highlights: • No carrier added 197(m)Hg. • 197(m)Hg promising for therapeutic application. • 197(m)Hg for imaging

  9. MOA-2007-BLG-197: Exploring the brown dwarf desert

    CERN Document Server

    Ranc, C; Albrow, M D; Kubas, D; Bond, I A; Batista, V; Beaulieu, J -P; Bennett, D P; Dominik, M; Dong, Subo; Fouqué, P; Gould, A; Greenhill, J; Jørgensen, U G; Kains, N; Menzies, J; Sumi, T; Bachelet, E; Coutures, C; Dieters, S; Prester, D Dominis; Donatowicz, J; Gaudi, B S; Han, C; Hundertmark, M; Horne, K; Kane, S R; Lee, C -U; Marquette, J -B; Park, B -G; Pollard, K R; Sahu, K C; Street, R; Tsapras, Y; Wambsganss, J; Williams, A; Zub, M; Abe, F; Fukui, A; Itow, Y; Masuda, K; Matsubara, Y; Muraki, Y; Ohnishi, K; Rattenbury, N; Saito, To; Sullivan, D J; Sweatman, W L; Tristram, P J; Yock, P C M; Yonehara, A

    2015-01-01

    We present the analysis of MOA-2007-BLG-197Lb, the first brown dwarf companion to a Sun-like star detected through gravitational microlensing. The event was alerted and followed-up photometrically by a network of telescopes from the PLANET, MOA, and uFUN collaborations, and observed at high angular resolution using the NaCo instrument at the VLT. From the modelling of the microlensing light curve, we derived the binary lens separation in Einstein radius units (s~1.13) and a mass ratio of (4.732+/-0.020)x10^{-2}. Annual parallax, lens orbital motion and finite source effects were included in the models. To recover the lens system's physical parameters, we combined the resulting light curve best-fit parameters with (J,H,Ks) magnitudes obtained with VLT NaCo and calibrated using IRSF and 2MASS data. We derived a lens total mass of 0.86+/-0.04 Msun and a lens distance of 4.2+/-0.3 kpc. We find that the companion of MOA-2007-BLG-197L is a brown dwarf of 41+/-2 Mjup observed at a projected separation of 4.3+/-0.1 A...

  10. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  11. Discovery of a Transient Magnetar: XTE J1810-197

    Science.gov (United States)

    Ibrahim, Alaa I.; Markwardt, Craig B.; Swank, Jean H.; Ransom, Scott; Roberts, Mallory; Kaspi, Victoria; Woods, Peter M.; Safi-Harb, Samar; Balman, Solen; Parke, William C.

    2004-01-01

    We report the discovery of a new X-ray pulsar, XTE J1810-197, that was serendipitously discovered on 2003 July 15 by the Rossi X-Ray Timing Explorer (RXTE) while observing the soft gamma repeater SGR 1806-20. The pulsar has a 5.54 s spin period, a soft X-ray spectrum (with a photon index of approx. = 4). and is detectable in earlier RXTE observations back to 2003 January but not before. These show that a transient outburst began between 2002 November 17 and 2003 January 23 and that the source's persistent X-ray flux has been declining since then. The pulsar exhibits a high spin-down rate P approx.= l0(exp -11) s/s with no evidence of Doppler shifts due to a binary companion. The rapid spin-down rate and slow spin period imply a supercritical characteristic magnetic field B approx. = 3 x l0(exp 14) G and a young age tau less than or = 7600 yr. Follow-up Chandra observations provided an accurate position of the source. Within its error radius, the 1.5 m Russian-Turkish Optical Telescope found a limiting magnitude R(sub c) = 21.5. All such properties are strikingly similar to those of anomalous X-ray pulsars ad soft gamma repeaters, providing strong evidence that the source is a new magnetar. However, archival ASCA and ROSAT observations found the source nearly 2 orders of magnitude fainter. This transient behavior and the observed long-term flux variability of the source in absence of an observed SGR-like burst activity make it the first confirmed transient magnetar and suggest that other neutron stars that share the properties of XTE 51810- 197 during its inactive phase may be unidentified transient magnetars awaiting detection via a similar activity. This implies a larger population of magnetars than previously surmised and a possible evolutionary connection between magnetars and other neutron star families. Subject headings: pulsars: general -pulsars: individual (XTE 51810- 197) - stars: magnetic fields -

  12. Studies of {sup 194,195,197}Po

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, M.P.; Ahmad, I.; Crowell, B. [and others

    1995-08-01

    The energy systematics of low-lying polonium states show sudden changes near N = 114. The observed drops in the low-lying levels of {sup 196,198}Po relative to the heavier isotopes indicate significant changes in the underlying structure of these nuclei. It is thought that this change is due to the onset of vibrational collectivity brought about by the quadrupole interaction between neutron and proton-pairs. In order to extend the Po systematics even further, we measured, for the first time, states in {sup 194,195,197}Po using the {sup 28}Si + {sup 170}Yb reaction at a beam energy of 142 MeV. The beam was supplied by ATLAS, and the data were taken with 10 Compton-suppressed Ge detectors placed at the target position of the Fragment Mass Analyzer. Preliminary level schemes were constructed for {sup 194,195,197}Po based on {gamma}-{gamma} and {gamma}-FMA coincidences. The results for {sup 194}Po show that the 2{sup +} - 0{sup +} transition energy decreased in energy by 140 keV relative to {sup 196}Po suggesting that this nucleus moved beyond the vibrational limit to more collective motion. An extrapolation of the systematics predicts that the 2{sup +} energy could drop another 140 keV between {sup 194}Po and {sup 192}Po which would indicate the onset of rotational motion. Currently, we have an approved experiment to investigate the decay of yrast isomers in {sup 194}Po which will allow us to (1) confirm our earlier level scheme of {sup 194}Po, and (2) assess the experimental conditions needed for a future study of {sup 192}Po.

  13. Photon and Pi 0 production in 197Au + 197Au collisions at √ SNN = 130 GeV

    International Nuclear Information System (INIS)

    Inclusive transverse momentum spectra of photons and π0s at mid-rapidity are studied as a function of collision centrality for 197Au+ 197Au collisions at √sNN = 130 GeV. Photon pair conversions have been reconstructed from charged tracks measured by the main Time Project Chamber of the STAR experiment at the RHIC heavy ion facility. The transverse momentum resolution of photons with this method is estimated to be Δpt/pt = 2% at 0.125 GeV/c and 5% at 2.5 GeV/c. Photon spectra were measured up to a transverse momentum of 2.4 GeV/c between ± 0.5 units of rapidity. The dominant photon production mechanism, the π0 → γγ decay, was measured between 0.25-2.5 GeV/c and ± 1 units of rapidity. Spectra are reported for the top 11%, 11-34% and 34-85% centrality classes. It was observed that in mid-central and central collisions the relative contribution of the π0 → γγ decay to the inclusive photon spectrum decreases above a transverse momentum of 1.65 GeV/c. In central collisions the magnitude of the decrease from pt = 1.65 GeV/c to 2.4 GeV/c is 20%. It is unlikely that contributions from other π0 decay channels and other particle decays fully explain this decrease. The centrality dependence on the shapes of the π0 spectra was analyzed with Boltmann and Bose-Einstein functions. In the transverse momentum windows of the spectra, the extracted temperatures are near 0.295 GeV. These temperatures are substantially higher than those extracted from π± spectra in a lower range of transverse momentum. This is an indication that the shapes of the pion spectra deviate from purely exponential shapes

  14. 26 CFR 1.197-2 - Amortization of goodwill and certain other intangibles.

    Science.gov (United States)

    2010-04-01

    .... Section 197 intangibles include goodwill. Goodwill is the value of a trade or business attributable to the expectancy of continued customer patronage. This expectancy may be due to the name or reputation of a trade or business or any other factor. (2) Going concern value. Section 197 intangibles include...

  15. Complete Genome Sequence of a New Enterococcus faecalis Bacteriophage, vB_EfaS_IME197.

    Science.gov (United States)

    Cheng, Shi; Xing, Shaozhen; Zhang, Xianglilan; Pei, Guangqian; An, Xiaoping; Mi, Zhiqiang; Huang, Yong; Tong, Yigang

    2016-01-01

    We report here the whole-genome sequence of a new Enterococcus faecalis phage, vB_EfaS_IME197, which has a linear double-stranded DNA genome of 41,307 bp with 34% G+C content. We describe the main features of the genome of vB_EfaS_IME197. PMID:27634987

  16. 13 CFR 120.197 - Notifying SBA's Office of Inspector General of suspected fraud.

    Science.gov (United States)

    2010-01-01

    ... Inspector General of suspected fraud. 120.197 Section 120.197 Business Credit and Assistance SMALL BUSINESS... of Inspector General of suspected fraud. Lenders, CDCs, Borrowers, and others must notify the SBA Office of Inspector General of any information which indicates that fraud may have occurred in...

  17. Complete Genome Sequence of a New Enterococcus faecalis Bacteriophage, vB_EfaS_IME197

    Science.gov (United States)

    Cheng, Shi; Xing, Shaozhen; Zhang, Xianglilan; Pei, Guangqian; An, Xiaoping; Mi, Zhiqiang; Huang, Yong

    2016-01-01

    We report here the whole-genome sequence of a new Enterococcus faecalis phage, vB_EfaS_IME197, which has a linear double-stranded DNA genome of 41,307 bp with 34% G+C content. We describe the main features of the genome of vB_EfaS_IME197. PMID:27634987

  18. Near-Barrier Neutron Transfer in Reactions 3,6He+197Au

    Science.gov (United States)

    Samarin, V. V.; Naumenko, M. A.; Penionzhkevich, Yu. E.; Skobelev, N. K.; Kroha, V.; Mrazek, J.

    2015-06-01

    Experimental excitation functions for near-barrier neutron transfer in 3,6He+197Au reactions have been measured and analyzed. Time-dependent Schrödinger equation and coupled channel equations for external neutrons of 3,6He and 197Au nuclei have been solved numerically taking into account spin-orbit interaction and Pauli exclusion principle.

  19. 14 CFR 121.197 - Airplanes: Turbine engine powered: Landing limitations: Alternate airports.

    Science.gov (United States)

    2010-01-01

    ... limitations: Alternate airports. 121.197 Section 121.197 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... airports. No person may list an airport as an alternate airport in a dispatch or flight release for a... obstruction clearance plane and the runway. In the case of an alternate airport for departure, as provided...

  20. Measurement of yields for the {sup 197}Au(γ,xn){sup 197-x}Au reactions induced by 2.5 GeV Bremsstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Hien, Nguyen Thi; Kim, Guinyun; Kim, Kwangsoo; Shahid, Muhammad; Zaman, Muhammah; Nadeem, Muhammad [Kyungpook National University, Daegu (Korea, Republic of); Khue, Pham Duc; Thanh, Kim Tien; Do, Nguyen Van [Vietnam Academy of Science and Technology, Hanoi (Viet Nam)

    2015-05-15

    Studies of high-energy nuclear reactions are of great important. It may help in deeper understanding of the reaction mechanisms and in extending of various fields of applications such as astrophysics, radiation physics, intense neutron source production and nuclear waste transmutation. The aim of the present work is to investigate the multineutron photonuclear on {sup 197}Au bombarded by 2.5 GeV Bremsstrahlung. Most of the photodisintegration products of gold with half-lives sufficient for the activity measurement. In this work, the necessary corrections were made in order to improve the accuracy of the experimental results The obtained experimental results are in good agreement with the calculated values. The yields for the {sup 197}Au(γ,xn){sup 197}-xAu reactions depend not only on the excitation energies but also on the number of neutrons ejected.

  1. 32 CFR Appendix A to Part 197 - Explanation of Freedom of Information Act (5 U.S.C. 552) Exemptions

    Science.gov (United States)

    2010-07-01

    ....C. 552) Exemptions A Appendix A to Part 197 National Defense Department of Defense (Continued... OFFICE OF THE SECRETARY OF DEFENSE (OSD) Pt. 197, App. A Appendix A to Part 197—Explanation of Freedom of Information Act (5 U.S.C. 552) Exemptions A. Exemptions Exemption Explanation (b)(1) Applies to...

  2. Fast neutron activation analysis of gold by inelastic scattering, 197Au(n,n'γ)197Aum, by means of plasma focus device

    International Nuclear Information System (INIS)

    The application of a Fast Neutron Activation Analysis (FNAA) technique on a samples of pure gold, irradiated by a plasma focus of 7 kJ, has been investigated. The reaction was the inelastic scattering of neutrons, 197Au(n,n'γ)197Aum. To avoid problems connected with peculiar features of the neutron emission from this kind of source, a preliminary standardization of the method has been carried out. The results obtained have a practical interest in view of possible applications to the technology of extraction of minerals. (author)

  3. Identification of intruder πi13/2 state in 197Tl

    Directory of Open Access Journals (Sweden)

    Pai H.

    2014-03-01

    Full Text Available The high-spin states in 197Tl were studied by populating them using the 197Au(α, 4n197 Tl reaction at 48 MeV of beam energy. γ−γ coincidence data were taken using a combination of clover, LEPS (low energy photon spectrometer and single crystal HPGe detectors. The polarization and DCO measurements were performed for definite spin and parity assignment of the excited states. The πi13/2 intruder state has been identified for the first time in this nucleus. The total Routhian surface calculations have been performed to study the shape and deformation of 197Tl for different configurations.

  4. Photoactivation experiment on 197Au and its implications for the dipole strength in heavy nuclei

    CERN Document Server

    Nair, C; Junghans, A R; Bemmerer, D; Beyer, R; Grosse, E; Klug, J; Kosev, K; Rusev, G; Schilling, K D; Schwengner, R; Wagner, A; 10.1103/PhysRevC.78.055802

    2008-01-01

    The 197Au(gamma,n) reaction is used as an activation standard for photodisintegration studies on astrophysically relevant nuclei. At the bremsstrahlung facility of the superconducting electron accelerator ELBE (Electron Linear accelerator of high Brilliance and low Emittance) of Forschungszentrum Dresden-Rossendorf, photoactivation measurements on 197Au have been performed with bremsstrahlung endpoint energies from 8.0 to 15.5 MeV. The measured activation yield is compared with previous experiments as well as with calculations using Hauser-Feshbach statistical models. It is shown that the experimental data are best described by a two-Lorentzian parametrization with taking the axial deformation of 197Au into account. The experimental 197Au(gamma,n) reaction yield measured at ELBE via the photoactivation method is found to be consistent with previous experimental data using photon scattering or neutron detection methods.

  5. 40 CFR 197.12 - What definitions apply in subpart B?

    Science.gov (United States)

    2010-07-01

    ... Public Health and Environmental Standards for Disposal § 197.12 What definitions apply in subpart B? All... dissolved (filterable) solids in water as determined by use of the method specified in 40 CFR part...

  6. MiR-197 induces Taxol resistance in human ovarian cancer cells by regulating NLK.

    Science.gov (United States)

    Zou, Dongling; Wang, Dong; Li, Rong; Tang, Ying; Yuan, Li; Long, Xingtao; Zhou, Qi

    2015-09-01

    Chemotherapy is the preferred therapeutic approach for the therapy of advanced ovarian cancer, but 5-year survival rate remains low due to the development of drug resistance. Increasing evidence has documented that microRNAs (miRNAs) act important roles in drug resistance in a variety types of cancer. However, the roles of miRNA in regulating Taxol resistance in ovarian cancer and the detailed mechanism are less reported. We used Taqman probe stem loop real-time PCR to accurately measure the levels of miR-197 in normal ovarian cells, ovarian cancer cells, and Taxol-resistant ovarian cancer cells and found that miR-197 was significantly increased in Taxol-resistant ovarian cancer cells. Enforced expression of miR-197 can promote Taxol resistance, cell proliferation, and invasion of ovarian cancer cells. Meanwhile, repression of miR-197 in ovarian cancer cells can sensitize its response to Taxol and also induced attenuated cell proliferation and invasion ability. Furthermore, investigation of the detailed mechanism showed that the promotion of miR-197 on drug resistance in ovarian cancer cells was partially mediated by downregulating NLK, a negative regulator of WNT signaling pathway. Taken together, our work first demonstrated that miR-197 can confer drug resistance to Taxol, by regulating tumor suppressor, NLK expression in ovarian cancer cells.

  7. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  8. Antigen Processing of the Heptavalent Pneumococcal Conjugate Vaccine Carrier Protein CRM197 Differs Depending on the Serotype of the Attached Polysaccharide

    OpenAIRE

    Leonard, Ethan G.; Canaday, David H.; Harding, Clifford V.; Schreiber, John R.

    2003-01-01

    The pneumococcal (Pn) conjugate vaccine includes seven different polysaccharides (PS) conjugated to CRM197. Utilizing antigen-processing cells and a CRM197-specific mouse T-cell hybridoma, we found that the serotype of conjugated PnPS dramatically affected antigen processing of CRM197. Unconjugated CRM197 and serotype conjugates 14 and 18C were processed more efficiently.

  9. Production of R 19.7 tex Rotor Yarn%R 19.7 tex转杯纱生产实践

    Institute of Scientific and Technical Information of China (English)

    赵艳; 韩利君

    2013-01-01

    To develop R 19.7 tex rotor yarn,according to viscose fiber characteristics,necessary technology measures were adopted in each process.Processing parameter was tested and optimized including raw material blending ratio,doubling number,draw sliver weight per unit,rotor speed and combing roller speed.Finally R 19.7 tex rotor yarn can be spun successfully,the quality can reach use demands.It is considered that the key rings of spinning fine viscose yarn are adopting larger ratio fine fiber,using three-times doubling,selecting lighter draw sliver weight per unit,optimizing rotor speed and combing roller speed,controlling temperature and humidity well.%为了开发R 19.7 tex转杯纱,针对粘胶纤维特点,在各工序采取必要工艺技术措施,并对原料混配比例、并合道数、熟条定量、转杯速度、分梳辊速度等工艺参数进行了试验优选,顺利纺制出R 19.7 tex转杯纱,较好地满足了使用要求.认为:选用较大比例细特纤维、采用三道并合、较轻熟条定量,优选转杯速度和分梳辊速度,控制好温湿度是纺好细号粘胶转杯纱的几个关键环节.

  10. Atlas of the Spectrum of a Platinum/Neon Hollow-Cathode Lamp in the Region 1130-4330 &#197

    Science.gov (United States)

    SRD 112 Atlas of the Spectrum of a Platinum/Neon Hollow-Cathode Lamp in the Region 1130-4330 &#197 (Web, free access)   Atlas of the Spectrum of a Platinum/Neon Hollow-Cathode Lamp in the Region 1130-4330 &#197 contains wavelengths and intensities for about 5600 lines in the region 4330 &#197. An atlas plot of the spectrum is given, with the spectral lines marked and their intensities, wavelengths, and classifications listed.

  11. 26 CFR 1.167(a)-14 - Treatment of certain intangible property excluded from section 197.

    Science.gov (United States)

    2010-04-01

    ... determined by amortizing the cost or other basis of the computer software using the straight line method... described in section 167(f)(3) and § 1.197-2(c)(11) is determined by using the straight line method... subject to the allowance for depreciation under section 167(a). (b) Computer software—(1) In general....

  12. 197Au Moessbauer study of gold ores, mattes, roaster products, and gold minerals

    International Nuclear Information System (INIS)

    The chemical state of gold in gold ores, mattes and roaster products has been studied by 197Au Moessbauer spectroscopy. Gold minerals were studied in order to provide reference data for the ore spectra. 57Fe Moessbauer spectroscopy was used to monitor the iron-compounds always present in gold ores and to follow their transformations caused by smelting and roasting. (orig.)

  13. Evolution of the X-ray Properties of the Transient Magnetar XTE J1810-197

    CERN Document Server

    Alford, Jason

    2016-01-01

    We report on X-ray observations of the 5.54 s transient magnetar XTE J1810-197 using the XMM-Newton and Chandra observatories, analyzing new data from 2008 through 2014, and re-analyzing data from 2003 through 2007 with the benefit of these six years of new data. From the discovery of XTE J1810-197 during its 2003 outburst to the most recent 2014 observations, its 0.3-10 keV X-ray flux has declined by a factor of about 50 from 4.1E-11 to 8.1E-13 erg/cm^2/s. Its X-ray spectrum has now reached a steady state. Pulsations continue to be detected from a 0.3 keV thermal hot-spot that remains on the neutron star surface. The luminosity of this hot-spot exceeds XTE J1810-197's spin down luminosity, indicating continuing magnetar activity. We find that XTE J1810-197's X-ray spectrum is best described by a multiple component blackbody model in which the coldest 0.14 keV component likely originates from the entire neutron star surface, and the thermal hot-spot is, at different epochs, well described by an either one or ...

  14. 33 CFR 110.197 - Galveston Harbor, Bolivar Roads Channel, Texas.

    Science.gov (United States)

    2010-07-01

    ... HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.197 Galveston Harbor, Bolivar.... 29°21′14.5″ N 94°45′49.0″ W. and thence to the point of beginning. (b) The regulations. (1) The... provisions in paragraph (b)(5) of this section. (8) Fixed moorings, piles or stakes, and floats or buoys...

  15. Evolution of the X-ray Properties of the Transient Magnetar XTE J1810-197

    Science.gov (United States)

    Alford, Jason

    2016-04-01

    We report on X-ray observations of the 5.54 s transient magnetar XTE J1810-197 using the XMM-Newton and Chandra observatories, analyzing new data from 2008 through 2014, and re-analyzing data from 2003 through 2007 with the benefit of these six years of new data. From the discovery of XTE J1810-197 during its 2003 outburst to the most recent 2014 observations, its 0.3-10 keV X-ray flux has declined by a factor of about 50 from 4.1E-11 to 8.1E-13 erg/cm^2/s. Its X-ray spectrum has now reached a steady state. Pulsations continue to be detected from a 0.3 keV thermal hot-spot that remains on the neutron star surface. The luminosity of this hot-spot exceeds XTE J1810-197's spin down luminosity, indicating continuing magnetar activity. We find that XTE J1810-197's X-ray spectrum is best described by a multiple component blackbody model in which the coldest 0.14 keV component likely originates from the entire neutron star surface, and the thermal hot-spot is, at different epochs, well described by an either one or two-component blackbody model. A 1.2 keV absorption line, possibly due to resonant proton scattering, is detected at all epochs. The X-ray flux of the hot spot decreased by approximately 20% between 2008 March and 2009 March, the same period during which XTE J1810-197 became radio quiet.

  16. High level accumulation of soluble diphtheria toxin mutant (CRM197) with co-expression of chaperones in recombinant Escherichia coli.

    Science.gov (United States)

    Mahamad, Pornpimol; Boonchird, Chuenchit; Panbangred, Watanalai

    2016-07-01

    CRM197 is the diphtheria toxin mutant used in many conjugate vaccines. A fusion CRM197 (fCRM197) containing all the tags conferred by the pET32a vector was produced as a soluble protein in Escherichia coli co-expressing several chaperone proteins in conjunction with low temperature cultivation. Trigger factor (Tf) enhanced formation of soluble fCRM197 (150.69 ± 8.95 μg/mL) to a greater degree than other chaperones when fCRM197 expression was induced at 25 °C for 12 h. However, prolonged cultivation resulted in a progressive reduction of fCRM197 accumulation. In contrast, at 15 °C cells, with or without Tf, fCRM197 accumulated to the highest level at 48 h (153.70 ± 13.14 μg/mL and 150.07 ± 8.13 μg/mL, respectively). Transmission electron microscopy (TEM) demonstrated that the formation of inclusion protein as well as cell lysis was reduced in cultures grown at 15 °C. Cell viability was substantially reduced in cells expressing Tf, compared to cultures without Tf, when fCRM197 was induced at 25 °C. The viability of Tf-expressing cells was enhanced when cultured at 15 °C. Both purified fCRM197 and CRM197 efficiently digested lambda DNA (λDNA) at 37 °C (92.78 and 97.45 %, respectively). Digestion efficiency of fCRM197 and CRM197 was reduced at 25 °C (80.80 and 62.73 %, respectively) and at 15 °C (7.34 and 24.79 %, respectively). These results demonstrating nuclease activity, enhanced cell lysis, and reduced cell viability are consistent with the finding of lower fCRM197 yield when cultivation and induction times were prolonged at 25 °C. The present work provides a procedure for the high-level production of soluble fCRM197 using E. coli as a heterologous host. PMID:27020286

  17. Novel methodology for the study of mercury methylation and reduction in sediments and water using 197Hg radiotracer.

    Science.gov (United States)

    Ribeiro Guevara, Sergio; Zizek, Suzana; Repinc, Urska; Pérez Catán, Soledad; Jaćimović, Radojko; Horvat, Milena

    2007-03-01

    Mercury tracers are powerful tools that can be used to study mercury transformations in environmental systems, particularly mercury methylation, demethylation and reduction in sediments and water. However, mercury transformation studies using tracers can be subject to error, especially when used to assess methylation potential. The organic mercury extracted can be as low as 0.01% of the endogenous labeled mercury, and artefacts and contamination present during methylmercury (MeHg) extraction processes can cause interference. Solvent extraction methods based on the use of either KBr/H2SO4 or HCl were evaluated in freshwater sediments using 197Hg radiotracer. Values obtained for the 197Hg tracer in the organic phase were up to 25-fold higher when HCl was used, which is due to the coextraction of 197Hg2+ into the organic phase during MeHg extraction. Evaluations of the production of MeHg gave similar results with both MeHg extraction procedures, but due to the higher Hg2+ contamination of the controls, the uncertainty in the determination was higher when HCl was used. The Hg2+ contamination of controls in the HCl extraction method showed a nonlinear correlation with the humic acid content of sediment pore water. Therefore, use of the KBr/H2SO4 method is recommended, since it is free from these interferences. 197Hg radiotracer (T1/2=2.673 d) has a production rate that is about 50 times higher than that of 203Hg (T1/2=46.595 d), the most frequently used mercury radiotracer. Hence it is possible to obtain a similar level of performance to 203Hg when it is used it in short-term experiments and produced by the irradiation of 196Hg with thermal neutrons, using mercury targets with the natural isotopic composition. However, if the 0.15% natural abundance of the 196Hg isotope is increased, the specific activity of the 197Hg tracer can be significantly improved. In the present work, 197Hg tracer was produced from mercury 51.58% enriched in the 196Hg isotope, and a 340-fold

  18. Re-evaluation and Re-commendation of Neutron Induced Data of 197Au

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The evaluation of neutron-induced data of 197Au with energy range from 10-5 eV to 20 MeV wascarried out. Based on the available measured data, the code APMN is used to get the neutron opticalpotential with energy region from 5 keV to 20 MeV based on the available measured data, such as totalcross section, non-elastic scattering cross sections and elastic angular distributions. The parameters for

  19. X-Ray Bursts from the Transient Magnetar Candidate XTE J1810-197

    Science.gov (United States)

    Kouveliotou, Chryssa; Woods, Peter M.; Gavriil, Fotis P.; Kaspi, Victoria M.; Roberts, Mallory S. E.; Ibrahim, Alaa; Markwardt, Craig B.; Swank, Jean H.; Finger, Mark H.

    2005-01-01

    We have discovered four X-ray bursts, recorded with the Rossi X-ray Timing Explorer Proportional Counter Array between 2003 September and 2004 April, that we show to originate from the transient magnetar candidate XTE 51810-197. The burst morphologies consist of a short spike or multiple spikes lasting approx. 1 s each followed by extended tails of emission where the pulsed flux from XTE 51810-197 is significantly higher. The burst spikes are likely correlated with the pulse maxima, having a chance probability of a random phase distribution of 0.4%. The burst spectra are best fit to a blackbody with temperatures 4-8 keV, considerably harder than the persistent X-ray emission. During the X-ray tails following these bursts, the temperature rapidly cools as the flux declines, maintaining a constant emitting radius after the initial burst peak. The temporal and spectral characteristics of these bursts closely resemble the bursts seen from 1E 1048.1-5937 and a subset of the bursts detected from 1E 2259+586, thus establishing XTE J1810-197 as a magnetar candidate. The bursts detected from these three objects are sufficiently similar to one another, yet si,g&cantly differe2t from those seen from soft gamma repeaters, that they likely represent a new class of bursts from magnetar candidates exclusive (thus far) to the anomalous X-ray pulsar-like sources.

  20. Mucosal vaccination against diphtheria using starch microparticles as adjuvant for cross-reacting material (CRM197) of diphtheria toxin.

    Science.gov (United States)

    Rydell, Niclas; Sjöholm, Ingvar

    2005-04-15

    Mucosal vaccination has the advantage of eliciting a local mucosal immune response as well as a systemic response. In this investigation, polyacryl starch microparticles were conjugated to diphtheria toxin cross-reacting material (CRM197) as a mucosal adjuvant for oral or intranasal immunisation of mice. Various methods of stabilising CRM197 with formaldehyde were investigated. A good systemic and local mucosal immune response was attained with oral immunisation when CRM197 was treated with a relatively low formaldehyde concentration prior to conjugation to the microparticles. No immune response was seen after intranasal immunisation.

  1. Association of G197 polymorphism of IL-17A gene with myocardial remodeling and aerobic performance in athletes.

    Science.gov (United States)

    Lifanov, A D; Khadyeva, M N; Demenev, S V; Knyazev, A N; Babushkin, Yu A; Astashina, E E

    2014-09-01

    We studied the relationship between G197A polymorphism of IL-17A gene and changes in morphometric echocardiography parameters and physiological parameters in skiers (19 examinees). Genotyping was performed by restriction fragment length polymorphism analysis and echocardiography using a Nemio MX ultrasound scanner (Toshiba). Association of 197A allele of IL-17A gene with low myocardial growth and high aerobic performance of athletes was demonstrated. PMID:25257435

  2. The Fading of Transient Anomalous X-Ray Pulsar XTE J1810-197

    Science.gov (United States)

    Halpern, J. P.; Gotthelf, E. V.

    2005-01-01

    Three observations of the 5.54 s transient anomalous X-ray pulsar XTE J1810-197 obtained over 6 months with the Newton X-ray Multi-Mirror (XMM-Newton) mission are used to study its spectrum and pulsed light curve as the source fades from outburst. The decay is consistent with an exponential of time constant ~300 days but not a power law as predicted in some models of sudden deep crustal heating events. All spectra are well fitted by a blackbody plus a steep power law, a problematic model that is commonly fitted to anomalous X-ray pulsars (AXPs). A two-temperature blackbody fit is also acceptable and better motivated physically in view of the faint optical/IR fluxes, the X-ray pulse shapes that weakly depend on energy in XTE J1810-197, and the inferred emitting areas that are less than or equal to the surface area of a neutron star. The fitted temperatures remained the same while the flux declined by 46%, which can be interpreted as a decrease in area of the emitting regions. The pulsar continues to spin down, albeit at a reduced rate of (5.1+/-1.6)×10-12 s s-1. The inferred characteristic age τc≡P/2P~17,000 yr, magnetic field strength Bs~1.7×1014 G, and outburst properties are consistent with both the outburst and quiescent X-ray luminosities being powered by magnetic field decay, i.e., XTE J1810-197 is a magnetar.

  3. Dependence of spleen sequestration on erythrocytes following administration of various concentrations of BMHP-197Hg

    International Nuclear Information System (INIS)

    In the course of routine splenic scintiscanning, the effects of BMHP-Hg197 concentrations on the kinetics of damaged erythrocytes and on image quality have been investigated. The following findings were obtained: 1. Significant displacement of the Price-Jones curve in dependence of BMHP concentrations. 2. No significant enzymatic changes 3. An enhanced labelling index at high concentrations and a higher spleen sequestration rate 4. A significant improvement of scintiscan quality at higher concentrations 5. Erythrocyte washing before incubation with BMHP was unnecessary as it does not improve the results to an extent that would warrant the tedious procedure. (orig.)

  4. Photon and Neutral Pi 0 production in (197)Au + (197)Au collisions at sqrt S(NN) = 130 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Ian J.

    2002-09-16

    Inclusive transverse momentum spectra of photons and {pi}{sup 0}s at mid-rapidity are studied as a function of collision centrality for {sup 197}Au+ {sup 197}Au collisions at {radical}s{sub NN} = 130 GeV. Photon pair conversions have been reconstructed from charged tracks measured by the main Time Project Chamber of the STAR experiment at the RHIC heavy ion facility. The transverse momentum resolution of photons with this method is estimated to be {Delta}p{sub t}/p{sub t} = 2% at 0.125 GeV/c and 5% at 2.5 GeV/c. Photon spectra were measured up to a transverse momentum of 2.4 GeV/c between {+-} 0.5 units of rapidity. The dominant photon production mechanism, the {pi}{sup 0} {yields} {gamma}{gamma} decay, was measured between 0.25-2.5 GeV/c and {+-} 1 units of rapidity. Spectra are reported for the top 11%, 11-34% and 34-85% centrality classes. It was observed that in mid-central and central collisions the relative contribution of the {pi}{sup 0} {yields} {gamma}{gamma} decay to the inclusive photon spectrum decreases above a transverse momentum of 1.65 GeV/c. In central collisions the magnitude of the decrease from p{sub t} = 1.65 GeV/c to 2.4 GeV/c is 20%. It is unlikely that contributions from other {pi}{sup 0} decay channels and other particle decays fully explain this decrease. The centrality dependence on the shapes of the {pi}{sup 0} spectra was analyzed with Boltmann and Bose-Einstein functions. In the transverse momentum windows of the spectra, the extracted temperatures are near 0.295 GeV. These temperatures are substantially higher than those extracted from {pi}{sup {+-}} spectra in a lower range of transverse momentum. This is an indication that the shapes of the pion spectra deviate from purely exponential shapes.

  5. CLINICAL OBSERVING AND ANALYSES OF ROOT-CARIES(197 CASES)%根面龋临床观察与分析(附197例)

    Institute of Scientific and Technical Information of China (English)

    刘虹; 谢晓莉; 米大丽

    2001-01-01

    Root-caries is the disease which is often occured in old people.We investigated 197 patients(40~85 years old) in stomatological clinic,and found that there were 114 patients who had root-caries,an the incidence of root-caries is 57.87 percent.There was a significantly different in incidence between middle-aged people and old ones(P<0.01),and no significantly diferent in incidence between men and women(P>0.05).This conclusion is different from some domestic reports.Root-Caries Index (RCI) is 0.26.The incidecnce of root-caries and value of RCI are directly proportionate with age,but value of RCI in group of 40~49 years old is higher than it in the group of 50~59 years old.Gingival atrophy is relate to root-caries closely.Root-caries is mostly occurred in mandibular molar teeth,and is seldom seen in mandibular front teeth.%根面龋是老年人常见的口腔疾病,我们对口腔门诊40~85岁197例患者进行调查,发现患根面龋人数114例,根龋发病率57.87%,中、老年人发病率有高度显著性差异(P<0.01),男女发病率差异无显著性(P>0.05),与国内有些报道相异。根龋指数RCI为0.26。受检患者根龋发病率、RCI值与年龄呈正相关,但40~49岁年龄组RCI数据高于50~59岁组。调查发现,牙龈退缩与根面龋密切相关。根龋发生最多的牙位是下磨牙,最少的是下前牙。

  6. The variable spin-down rate of the transient magnetar XTE J1810--197

    CERN Document Server

    Pintore, F; Mereghetti, S; Esposito, P; Turolla, R; Rea, N; Zelati, F Coti; Israel, G L; Tiengo, A; Zane, S

    2016-01-01

    We have analyzed XMM-Newton and Chandra observations of the transient magnetar XTE J1810-197, spanning more than 11 years, from the initial phases of the 2003 outburst to the current quiescent level. We investigated the evolution of the pulsar spin period and we found evidence for two distinct regimes: during the outburst decay, the spin derivative (nu_dot) was highly variable in the range -(2-4.5)x10^-13 Hz/s, while during quiescence the spin-down rate was more stable at an average value of -1x10^{-13} Hz/s. Only during ~3000 days (from MJD 54165 to MJD 56908) in the quiescent stage, it was possible to find a phase-connected timing solution, with nu_dot = -4.9x10^{-14} Hz/s, and a positive second frequency derivative, nu_dotdot = 1.8x10^{-22} Hz/s. These results are in agreement with the behavior expected if the outburst of XTE J1810-197 was due to a strong magnetospheric twist.

  7. The variable spin-down rate of the transient magnetar XTE J1810-197

    Science.gov (United States)

    Pintore, Fabio; Bernardini, Federico; Mereghetti, Sandro; Esposito, Paolo; Turolla, Roberto; Rea, Nanda; Coti Zelati, Francesco; Israel, Gian Luca; Tiengo, Andrea; Zane, Silvia

    2016-05-01

    We have analysed XMM-Newton and Chandra observations of the transient magnetar XTE J1810-197 spanning more than 11 yr, from the initial phases of the 2003 outburst to the current quiescent level. We investigated the evolution of the pulsar spin period and we found evidence for two distinct regimes: during the outburst decay, dot{ν } was highly variable in the range -(2-4.5) × 10-13 Hz s-1, while during quiescence the spin-down rate was more stable at an average value of -1 × 10-13 Hz s-1. Only during ˜3000 d (from MJD 54165 to MJD 56908) in the quiescent stage it was possible to find a phase-connected timing solution, with dot{ν }=-4.9× 10^{-14} Hz s-1, and a positive second frequency derivative, ddot{ν }=1.8× 10^{-22} Hz s-2. These results are in agreement with the behaviour expected if the outburst of XTE J1810-197 was due to a strong magnetospheric twist.

  8. Carrier priming effect of CRM197 is related to an enhanced B and T cell activation in meningococcal serogroup A conjugate vaccination. Immunological comparison between CRM197 and diphtheria toxoid.

    Science.gov (United States)

    Pecetta, S; Tontini, M; Faenzi, E; Cioncada, R; Proietti, D; Seubert, A; Nuti, S; Berti, F; Romano, M R

    2016-04-29

    Glycoconjugate vaccines are composed of capsular polysaccharides (CPSs) of a pathogenic bacteria covalently linked to carrier proteins. Pre-exposure to the carrier is known to influence the efficacy of the glycoconjugate, by inducing enhanced or suppressed anti-CPS response. Following our previous work on the immunogenicity of diphtheria toxin mutant CRM197 and formaldehyde-treated diphtheria toxoid (DT) as carriers for meningococcal A (MenA) conjugates in mouse model, we further investigated the role of the carrier on the immunological response to glycoconjugate vaccines. We previously showed that high dosage DT priming could result in carrier-induced epitopic suppression (CIES), an event that did not occur for CRM197 priming, and we observed that anti-DT IgGs could cross-react with DT based conjugates in vitro. Here, we confirmed the cross-reactivity of anti-carrier IgGs with DT conjugates in vivo. Furthermore, we analyzed the splenocytes of animals primed with the carrier and subsequently immunized with the MenA conjugate. Pre-exposure to the carrier protein, both CRM197 and DT, resulted in increased carrier-specific plasma and memory B cell response. However, only for CRM197 priming an enhanced carbohydrate-specific plasma cell response was observed. Analysis of circulating IgGs confirmed these observations. Memory to the CPS resulted to be non-influenced by carrier priming. Analysis of T helper response showed an enhancement effect for CRM197 priming, while DT priming resulted in constrained T cell activation. Stimulation with CRM197, which does not require formaldehyde detoxification, of splenocytes from animal immunized with DT suggested that the formaldehyde treatment used to produce DT might be the cause of limited presentation of the antigen to the T cells. We concluded that the dominant carrier-specific B cell response in case of limited T cell recruitment might explain the previously observed CIES phenomenon in case of DT priming.

  9. Carrier priming effect of CRM197 is related to an enhanced B and T cell activation in meningococcal serogroup A conjugate vaccination. Immunological comparison between CRM197 and diphtheria toxoid.

    Science.gov (United States)

    Pecetta, S; Tontini, M; Faenzi, E; Cioncada, R; Proietti, D; Seubert, A; Nuti, S; Berti, F; Romano, M R

    2016-04-29

    Glycoconjugate vaccines are composed of capsular polysaccharides (CPSs) of a pathogenic bacteria covalently linked to carrier proteins. Pre-exposure to the carrier is known to influence the efficacy of the glycoconjugate, by inducing enhanced or suppressed anti-CPS response. Following our previous work on the immunogenicity of diphtheria toxin mutant CRM197 and formaldehyde-treated diphtheria toxoid (DT) as carriers for meningococcal A (MenA) conjugates in mouse model, we further investigated the role of the carrier on the immunological response to glycoconjugate vaccines. We previously showed that high dosage DT priming could result in carrier-induced epitopic suppression (CIES), an event that did not occur for CRM197 priming, and we observed that anti-DT IgGs could cross-react with DT based conjugates in vitro. Here, we confirmed the cross-reactivity of anti-carrier IgGs with DT conjugates in vivo. Furthermore, we analyzed the splenocytes of animals primed with the carrier and subsequently immunized with the MenA conjugate. Pre-exposure to the carrier protein, both CRM197 and DT, resulted in increased carrier-specific plasma and memory B cell response. However, only for CRM197 priming an enhanced carbohydrate-specific plasma cell response was observed. Analysis of circulating IgGs confirmed these observations. Memory to the CPS resulted to be non-influenced by carrier priming. Analysis of T helper response showed an enhancement effect for CRM197 priming, while DT priming resulted in constrained T cell activation. Stimulation with CRM197, which does not require formaldehyde detoxification, of splenocytes from animal immunized with DT suggested that the formaldehyde treatment used to produce DT might be the cause of limited presentation of the antigen to the T cells. We concluded that the dominant carrier-specific B cell response in case of limited T cell recruitment might explain the previously observed CIES phenomenon in case of DT priming. PMID:27015733

  10. Near-barrier neutron transfer in reactions 3,6He + 45Sc and 3,6He + 197Au

    Science.gov (United States)

    Samarin, V. V.; Naumenko, M. A.; Penionzhkevich, Yu E.; Skobelev, N. K.; Kroha, V.; Mrazek, J.

    2016-06-01

    Experimental cross sections for formation of 196,198Au isotopes in reactions 3,6He + 197Au and cross sections for formation of 44,46Sc isotopes in reactions 3,6He + 45Sc have been analyzed. To calculate neutron transfer probabilities and cross sections the time- dependent Schrödinger equation for external neutrons of 3He, 6He, 45Sc and 197Au nuclei has been solved numerically. It is shown that the contribution of fusion and subsequent evaporation is significant in the case of reactions 3,6He + 45Sc, whereas in the case of reactions 3,6He + 197Au, it is negligible. Fusion-evaporation was taken into account using NRV evaporation code. Results of calculations demonstrate overall satisfactory agreement with experimental data.

  11. Misdiagnostic analysis of clinically diagnosed severe acute respiratory syndrome after following up 197 convalescent patients

    Institute of Scientific and Technical Information of China (English)

    LIU You-ning; TIAN Qing; HU Hong; XIE Li-xin; FAN Bao-xing; XU Hong-min; CHEN Wei-jun

    2005-01-01

    @@ The severe acute respiratory syndrome (SARS) is an emerging and highly contagious infection caused by a newly discovered strain of coronavirus.1 Since the clinical case definition of SARS is similar to other severe atypical pneumonias, specific laboratory tests that can accurately diagnose SARS-associated coronavirus (SARS-CoV) infection are important. However, published data are insufficient to investigate whether clinically diagnosed SARS patients may include some non-SARS pneumonia. Therefore, we aimed to determine clinical and laboratory features to differentiate SARS patients from non-SARS pneumonias that could reduce misdiagnosis of SARS. A retrospective analysis of clinical and laboratory characteristics after the initial onset of SARS, as well as its convalescent-phase, was examined from clinically diagnosed 197 SARS patients.

  12. 197Au İçin Reaksiyon Tesir Kesiti Hesaplamaları

    OpenAIRE

    ÖZDOĞAN, Hasan; KAPLAN, Abdullah

    2013-01-01

    Özet: Bu çalışmada, 197Au izotopunun nötron üretim tesir kesitleri denge ve denge-öncesi nükleer reaksiyon modelleri kullanılarak hesaplanmıştır. Denge durumu hesaplamaları için; Weisskopf-Ewing model, denge-öncesi hesaplamalar için ise; Hibrit, Geometri Bağımlı Hibrit ve İki Bileşenli Eksiton model kullanılmıştır. Weisskopf-Ewing, Hibrit ve Geometri Bağımlı Hibrit modelleri için ALICE/ASH; İki Bileşenli Eksiton modeli için TALYS 1.2 bilgisayar programları kullanılmıştır. Hesaplanan tesir kes...

  13. Breakup mechanisms for 7Li + 197Au, 204Pb systems at sub-barrier energies

    Directory of Open Access Journals (Sweden)

    Luong D.H.

    2013-12-01

    Full Text Available Coincidence measurements of breakup fragments were carried out for the 7Li + 197Au and 204Pb systems at sub-barrier energies. The mechanisms triggering breakup, and time-scales of each process, were identified through the reaction Q-values and the relative energy of the breakup fragments. Binary breakup of 7Li were found to be predominantly triggered by nucleon transfer, with p-pickup leading to 8Be → α + α decay being the preferred breakup mode. From the time-scales of each process, the coincidence yields were separated into prompt and delayed components, allowing the identification of breakup process important in the suppression of complete fusion of 7Li at above-barrier energies.

  14. ASASSN-16km: Discovery of A Supernova in ESO 197-G 010

    Science.gov (United States)

    Brown, J. S.; Prieto, J. L.; Ricci, C.; Oh, K.; Stanek, K. Z.; Holoien, T. W.-S.; Kochanek, C. S.; Shields, J.; Shappee, B. J.; Bersier, D.; Dong, Subo; Bose, S.; Chen, Ping; Brimacombe, J.

    2016-09-01

    During the ongoing All Sky Automated Survey for SuperNovae (ASAS-SN or "Assassin"), using data from the quadruple 14-cm "Cassius" telescope in Cerro Tololo, Chile, we discovered a Type Ia supernova in the galaxy ESO 197-G 010. ASASSN-16km (AT 2016ggb) was discovered in images obtained on UT 2016-09-12.34 at V~16.3 mag. We also detect the object in images obtained on UT 2016-09-13.15 (V~16.2), UT 2016-09-10.15 (V~16.3), UT 2016-09-09.15 (V~16.6), UT 2016-09-05.110 (V~17.1), and UT 2016-09-02.41 (V~17.6).

  15. FUSION OF SI-28 NUCLEI AT 12.4, 19.7, AND 30.0 MEV NUCLEON

    NARCIS (Netherlands)

    MEIJER, RJ; BOX, PF; DECOWSKI, P; GIERLIK, E; KAMERMANS, R; VANNIEWENHUIZEN, GJ; GRIFFIOEN, KA; WILSCHUT, HW; GIORNI, A; MORAND, C; DEMEYER, A; GUINET, D

    1991-01-01

    Detailed angular distributions of protons and alpha particles detected in coincidence with evaporation residues have been measured for the reaction Si-28+Si-28 at 12.4, 19.7, and 30.0 MeV/nucleon. We have separated these angular distributions into pre-equilibrium and evaporation components. The inva

  16. Mercury methylation and reduction potentials in marine water: An improved methodology using {sup 197}Hg radiotracer

    Energy Technology Data Exchange (ETDEWEB)

    Koron, Neza [National Institute of Biology, Marine Biology Station, Fornace 41, 6330 Piran (Slovenia); Bratkic, Arne [Department of Environmental Sciences, ' Jozef Stefan' Institute, Jamova 39, 1000 Ljubljana (Slovenia); Ribeiro Guevara, Sergio, E-mail: ribeiro@cab.cnea.gov.ar [Laboratorio de Analisis por Activacion Neutronica, Centro Atomico Bariloche, Av. Bustillo km 9.5, 8400 Bariloche (Argentina); Vahcic, Mitja; Horvat, Milena [Department of Environmental Sciences, ' Jozef Stefan' Institute, Jamova 39, 1000 Ljubljana (Slovenia)

    2012-01-15

    A highly sensitive laboratory methodology for simultaneous determination of methylation and reduction of spiked inorganic mercury (Hg{sup 2+}) in marine water labelled with high specific activity radiotracer ({sup 197}Hg prepared from enriched {sup 196}Hg stable isotope) was developed. A conventional extraction protocol for methylmercury (CH{sub 3}Hg{sup +}) was modified in order to significantly reduce the partitioning of interfering labelled Hg{sup 2+} into the final extract, thus allowing the detection of as little as 0.1% of the Hg{sup 2+} spike transformed to labelled CH{sub 3}Hg{sup +}. The efficiency of the modified CH{sub 3}Hg{sup +} extraction procedure was assessed by radiolabelled CH{sub 3}Hg{sup +} spikes corresponding to concentrations of methylmercury between 0.05 and 4 ng L{sup -1}. The recoveries were 73.0{+-}6.0% and 77.5{+-}3.9% for marine and MilliQ water, respectively. The reduction potential was assessed by purging and trapping the radiolabelled elemental Hg in a permanganate solution. The method allows detection of the reduction of as little as 0.001% of labelled Hg{sup 2+} spiked to natural waters. To our knowledge, the optimised methodology is among the most sensitive available to study the Hg methylation and reduction potential, therefore allowing experiments to be done at spikes close to natural levels (1-10 ng L{sup -1}). - Highlights: Black-Right-Pointing-Pointer Inorganic mercury methylation and reduction in marine water were studied. Black-Right-Pointing-Pointer High specific activity {sup 197}Hg was used to label Hg{sup 2+} spikes at natural levels. Black-Right-Pointing-Pointer Methylmercury extraction had 73% efficiency for 0.05-4 ng L{sup -1} levels. Black-Right-Pointing-Pointer High sensibility to assess methylation potentials, below 0.1% of the spike. Black-Right-Pointing-Pointer High sensibility also for reduction potentials, as low as 0.001% of the spike.

  17. Radio Disappearance of the Magnetar XTE J1810-197 and Continued X-ray Timing

    Science.gov (United States)

    Camilo, F.; Ransom, S. M.; Halpern, J. P.; Alford, J. A. J.; Cognard, I.; Reynolds, J. E.; Johnston, S.; Sarkissian, J.; van Straten, W.

    2016-04-01

    We report on timing, flux density, and polarimetric observations of the transient magnetar and 5.54 s radio pulsar XTE J1810-197 using the Green Bank, Nançay, and Parkes radio telescopes beginning in early 2006, until its sudden disappearance as a radio source in late 2008. Repeated observations through 2016 have not detected radio pulsations again. The torque on the neutron star, as inferred from its rotation frequency derivative \\dot{ν }, decreased in an unsteady manner by a factor of three in the first year of radio monitoring, until approximately mid-2007. By contrast, during its final year as a detectable radio source, the torque decreased steadily by only 9%. The period-averaged flux density, after decreasing by a factor of 20 during the first 10 months of radio monitoring, remained relatively steady in the next 22 months, at an average of 0.7 ± 0.3 mJy at 1.4 GHz, while still showing day-to-day fluctuations by factors of a few. There is evidence that during this last phase of radio activity the magnetar had a steep radio spectrum, in contrast to earlier flat-spectrum behavior. No secular decrease presaged its radio demise. During this time, the pulse profile continued to display large variations; polarimetry, including of a new profile component, indicates that the magnetic geometry remained consistent with that of earlier times. We supplement these results with X-ray timing of the pulsar from its outburst in 2003 up to 2014. For the first 4 years, XTE J1810-197 experienced non-monotonic excursions in frequency derivative by at least a factor of eight. But since 2007, its \\dot{ν } has remained relatively stable near its minimum observed value. The only apparent event in the X-ray record that is possibly contemporaneous with the radio shutdown is a decrease of ≈20% in the hot-spot flux in 2008-2009, to a stable, minimum value. However, the permanence of the high-amplitude, thermal X-ray pulse, even after the (unexplained) radio demise, implies

  18. m197wo.m77t and m197wo.h77t: MGD77T data and header files for single-beam bathymetry data for field activity M-1-97-WO in Southwest Washington Inner Shelf from 07/07/1997 to 07/15/1997

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS and GPS navigation data were collected as part of the U.S. Geological Survey cruise M-1-97-WO. The cruise was conducted...

  19. Negative parity low-spin states of even–odd {sup 187–197}Pt isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Kassim, Huda H.; Sharrad, Fadhil I., E-mail: fadhil.altaie@gmail.com

    2015-01-15

    In this paper, the negative parity low-spin states of even–odd {sup 187–197}Pt isotopes have been studied within the framework of the Interacting Boson–Fermion Model (IBFM-1). The single fermion is assumed to be in one of the 2f5/2, 3p3/2 and 3p1/2 single-particle orbits. The calculated negative parity low-states energy spectra agree quite well with the experimental data. The B(E2) values have been also calculated and compared with the experimental data. The calculated energy levels and B(E2) are in good agreement with experimental data than that in the previous study for {sup 195}Pt isotope. Furthermore, the energy levels, electric quadrupole transition probabilities and the potential energy surface for even–even platinum isotopes (as core for even–odd nuclei) have been calculated within framework of the Interacting Boson Model (IBM-1). The predicted energy levels and B(E2) transition probabilities results are reasonably consistent with the experimental data. The contour plot of the potential energy surfaces shows all interesting nuclei are deformed and have γ-unstable-like characters.

  20. A 197Au and 57Fe Moessbauer study of the roasting of refractory gold ores

    International Nuclear Information System (INIS)

    The transformation of chemically bound gold into metallic gold during industrial scale roasting of an arsenical gold ore concentrate from the Fairview Mine, Eastern Transvaal, has been studied quantitatively by 197Au Moessbauer spectroscopy. The iron compounds in the concentrate, mainly FeAsS and FeS2, and their transformations during roasting have been studied by 57Fe Moessbauer spectroscopy. The bound gold is found to convert into the metal in parallel to the decomposition of FeAsS and the increase in cyanide leachability. This shows that the refractory character of the ore is caused by the chemical bonding of the gold rather than by the physical inclusion of small, discrete metallic particles in the matrix of FeAsS or FeS2. The ratio of the f-factors of gold bound in the FeAsS component of a refractory ore and of metallic gold was determined to be f(Au:FeAsS)/f(Au)=1.48 ± 0.09. (orig.)

  1. Quantitative renal scintigraphy: anatomo-clinical and biological correlation (concerning 51 mercury 197 renal scintigraphs)

    International Nuclear Information System (INIS)

    To find out whether the renal mercury uptake measurement in urology is a satisfactory way to judge the separate functional value of the kidneys the records of 51 patients were examined. The exploration took place as follows: - injection of 300 μCi 197HgCl2, - measurement of the radioactivity fixed on each kidney, three days later, by means of a gamma camera. Of these 51 uptake measurements only one result appears inconsistent by excess. All the others agree perfectly with comparative observations. On the whole a close correlation is found between the renal mercury uptake measurement and the various clinical, urographic and anatomical data obtained on this group of patients. The method seems to be ideal because reliable, harmless and repeatable. Where dosimetry is concerned an injected dose of 300μCi delivers 9mrad to each kidney, 6mrad to the ovaries. By way of comparison it is interesting to note that an intraveinous urograph with 5 exposures delivers 500mrad to the ovaries. It is considered safe to repeat the examination 3 to 4 times on one patient

  2. Radio disappearance of the magnetar XTE J1810-197 and continued X-ray timing

    CERN Document Server

    Camilo, F; Halpern, J P; Alford, J A J; Cognard, I; Reynolds, J E; Johnston, S; Sarkissian, J; van Straten, W

    2016-01-01

    We report on timing, flux density, and polarimetric observations of the transient magnetar and 5.54 s radio pulsar XTE J1810-197 using the GBT, Nancay, and Parkes radio telescopes beginning in early 2006, until its sudden disappearance as a radio source in late 2008. Repeated observations through 2016 have not detected radio pulsations again. The torque on the neutron star, as inferred from its rotation frequency derivative f-dot, decreased in an unsteady manner by a factor of 3 in the first year of radio monitoring. In contrast, during its final year as a detectable radio source, the torque decreased steadily by only 9%. The period-averaged flux density, after decreasing by a factor of 20 during the first 10 months of radio monitoring, remained steady in the next 22 months, at an average of 0.7+/-0.3 mJy at 1.4 GHz, while still showing day-to-day fluctuations by factors of a few. There is evidence that during this last phase of radio activity the magnetar had a steep radio spectrum, in contrast to earlier be...

  3. $^{197}$Au($n,\\gamma$) cross section in the unresolved resonance region

    CERN Document Server

    Lederer, C.; Domingo-Pardo, C; Gunsing, F; Kappeler, F; Massimi, C.; Mengoni, A.; Wallner, A.; Abbondanno, U.; Aerts, G.; Alvarez, H.; Alvarez-Velarde, F.; Andriamonje, S.; Andrzejewski, J.; Assimakopoulos, P.; Audouin, L.; Badurek, G.; Barbagallo, M.; Baumann, P.; Becvar, F.; Belloni, F.; Berthoumieux, E.; Calviani, M.; Calvino, F.; Cano-Ott, D.; Capote, R.; Carrapico, C.; Carrillo de Albornoz, A.; Cennini, P.; Chepel, V.; Chiaveri, E.; Cortes, G.; Couture, A.; Cox, J.; Dahlfors, M.; David, S.; Dillmann, I.; Dolfini, R.; Dridi, W.; Duran, I.; Eleftheriadis, C.; Embid-Segura, M.; Ferrant, L.; Ferrari, A.; Ferreira-Marques, R.; Fitzpatrick, L.; Frais-Koelbl, H.; Fujii, K.; Furman, W.; Goncalves, I.; Gonzalez-Romero, E.; Goverdovski, A.; Gramegna, F.; Griesmayer, E.; Guerrero, C.; Haas, B.; Haight, R.; Heil, M.; Herrera-Martinez, A.; Igashira, M.; Isaev, S.; Jericha, E.; Kadi, Y.; Karadimos, D.; Karamanis, D.; Kerveno, M.; Ketlerov, V.; Koehler, P.; Konovalov, V.; Kossionides, E.; Krticka, M.; Lampoudis, C.; Leeb, H.; Lindote, A.; Lopes, I.; Losito, R.; Lozano, M.; Lukic, S.; Marganiec, J.; Marques, L.; Marrone, S.; Martinez, T.; Mastinu, P.; Mendoza, E.; Milazzo, P.M.; Moreau, C.; Mosconi, M.; Neves, F.; Oberhummer, H.; O'Brien, S.; Oshima, M.; Pancin, J.; Papachristodoulou, C.; Papadopoulos, C.; Paradela, C.; Patronis, N.; Pavlik, A.; Pavlopoulos, P.; Perrot, L.; Pigni, M.T.; Plag, R.; Plompen, A.; Plukis, A.; Poch, A.; Praena, J.; Pretel, C.; Quesada, J.; Rauscher, T.; Reifarth, R.; Rosetti, M.; Rubbia, C.; Rudolf, G.; Rullhusen, P.; Salgado, J.; Santos, C.; Sarchiapone, L.; Sarmento, R.; Savvidis, I.; Stephan, C.; Tagliente, G.; Tain, J.L.; Tarrio, D.; Tassan-Got, L.; Tavora, L.; Terlizzi, R.; Vannini, G.; Vaz, P.; Ventura, A.; Villamarin, D.; Vlachoudis, V.; Vlastou, R.; Voss, F.; Walter, S.; Wendler, H.; Wiescher, M.; Wisshak, K.

    2011-01-01

    The cross section of the reaction (197)Au(n,gamma) was measured with the time-of-flight technique at the n_TOF (neutron time-of-flight) facility in the unresolved resonance region between 5 and 400 keV using a pair of C(6)D(6) (where D denotes (2)H) liquid scintillators for the detection of prompt capture gamma rays. The results with a total uncertainty of 3.9%-6.7% for a resolution of 20 bins per energy decade show fair agreement with the Evaluated Nuclear Data File Version B-VII.0 (ENDF B-VII.0), which contains the standard evaluation. The Maxwellian-averaged cross section (MACS) at 30 keV is in excellent agreement with the one according to the ENDF/B-VII.0 evaluation and 4.7% higher than the MACS measured independently by activation technique. Structures in the cross section, which had also been reported earlier, have been interpreted as being due to clusters of resonances.

  4. 197 Candidates and 104 Validated Planets in K2's First Five Fields

    CERN Document Server

    Crossfield, Ian J M; Petigura, Erik A; Sinukoff, Evan; Schlieder, Joshua E; Howard, Andrew W; Beichman, Charles A; Isaacson, Howard; Dressing, Courtney D; Christiansen, Jessie L; Fulton, Benjamin J; Lépine, Sébastien; Weiss, Lauren; Hirsch, Lea; Livingston, John; Baranec, Christoph; Law, Nicholas M; Riddle, Reed; Ziegler, Carl; Howell, Steve B; Horch, Elliott; Everett, Mark; Teske, Johanna; Martinez, Arturo O; Obermeier, Christian; Benneke, Björn; Scott, Nic; Deacon, Niall; Aller, Kimberly M; Hansen, Brad M S; Mancini, Luigi; Ciceri, Simona; Brahm, Rafael; Jordán, Andrés; Knutson, Heather A; Henning, Thomas; Bonnefoy, Michaël; Liu, Michael C; Crepp, Justin R; Lothringer, Joshua; Hinz, Phil; Bailey, Vanessa; Skemer, Andrew; Defrere, Denis

    2016-01-01

    We present 197 planet candidates discovered using data from the first year of the NASA K2 mission (Campaigns 0-4), along with the results of an intensive program of photometric analyses, stellar spectroscopy, high-resolution imaging, and statistical validation. We distill these candidates into sets of 104 validated planets (57 in multi-planet systems), 30 false positives, and 63 remaining candidates. Our validated systems span a range of properties, with median values of R_P = 2.3 R_E, P=8.6 d, Tef = 5300 K, and Kp=12.7 mag. Stellar spectroscopy provides precise stellar and planetary parameters for most of these systems. We show that K2 has increased by 30% the number of small planets known to orbit moderately bright stars (1-4 R_E, Kp=9-13 mag). Of particular interest are 37 planets smaller than 2 R_E, 15 orbiting stars brighter than Kp=11.5, five receiving Earth-like irradiation levels, and several multi-planet systems -- including four planets orbiting the M dwarf K2-72 near mean-motion resonances. By quan...

  5. Novel methodology for the study of mercury methylation and reduction in sediments and water using {sup 197}Hg radiotracer

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro Guevara, Sergio; Perez Catan, Soledad [Centro Atomico Bariloche, Laboratorio de Analisis por Activacion Neutronica, Bariloche (Argentina); Zizek, Suzana; Repinc, Urska; Jacimovic, Radojko; Horvat, Milena [Jozef Stefan Institute, Department of Environmental Sciences, Ljubljana (Slovenia)

    2007-03-15

    Mercury tracers are powerful tools that can be used to study mercury transformations in environmental systems, particularly mercury methylation, demethylation and reduction in sediments and water. However, mercury transformation studies using tracers can be subject to error, especially when used to assess methylation potential. The organic mercury extracted can be as low as 0.01% of the endogenous labeled mercury, and artefacts and contamination present during methylmercury (MeHg) extraction processes can cause interference. Solvent extraction methods based on the use of either KBr/H{sub 2}SO{sub 4} or HCl were evaluated in freshwater sediments using {sup 197}Hg radiotracer. Values obtained for the {sup 197}Hg tracer in the organic phase were up to 25-fold higher when HCl was used, which is due to the coextraction of {sup 197}Hg{sup 2+} into the organic phase during MeHg extraction. Evaluations of the production of MeHg gave similar results with both MeHg extraction procedures, but due to the higher Hg{sup 2+} contamination of the controls, the uncertainty in the determination was higher when HCl was used. The Hg{sup 2+} contamination of controls in the HCl extraction method showed a nonlinear correlation with the humic acid content of sediment pore water. Therefore, use of the KBr/H{sub 2}SO{sub 4} method is recommended, since it is free from these interferences. {sup 197}Hg radiotracer (T{sub 1/2} = 2.673 d) has a production rate that is about 50 times higher than that of {sup 203}Hg (T{sub 1/2} = 46.595 d), the most frequently used mercury radiotracer. Hence it is possible to obtain a similar level of performance to {sup 203}Hg when it is used it in short-term experiments and produced by the irradiation of {sup 196}Hg with thermal neutrons, using mercury targets with the natural isotopic composition. However, if the 0.15% natural abundance of the {sup 196}Hg isotope is increased, the specific activity of the {sup 197}Hg tracer can be significantly improved. In

  6. Carrier priming with CRM 197 or diphtheria toxoid has a different impact on the immunogenicity of the respective glycoconjugates: biophysical and immunochemical interpretation.

    Science.gov (United States)

    Pecetta, S; Lo Surdo, P; Tontini, M; Proietti, D; Zambonelli, C; Bottomley, M J; Biagini, M; Berti, F; Costantino, P; Romano, M R

    2015-01-01

    Glycoconjugate vaccines play an enormous role in preventing infectious diseases. The main carrier proteins used in commercial conjugate vaccines are the non-toxic mutant of diphtheria toxin (CRM197), diphtheria toxoid (DT) and tetanus toxoid (TT). Modern childhood routine vaccination schedules include the administration of several vaccines simultaneously or in close sequence, increasing the concern that the repeated exposure to conjugates based on these carrier proteins might interfere with the anti-polysaccharide response. Extending previous observations we show here that priming mice with CRM197 or DT does not suppress the response to the carbohydrate moiety of CRM197 meningococcal serogroup A (MenA) conjugates, while priming with DT can suppress the response to DT-MenA conjugates. To explain these findings we made use of biophysical and immunochemical techniques applied mainly to MenA conjugates. Differential scanning calorimetry and circular dichroism data revealed that the CRM197 structure was altered by the chemical conjugation, while DT and the formaldehyde-treated form of CRM197 were less impacted, depending on the degree of glycosylation. Investigating the binding and avidity properties of IgGs induced in mice by non-conjugated carriers, we found that CRM197 induced low levels of anti-carrier antibodies, with decreased avidity for its MenA conjugates and poor binding to DT and respective MenA conjugates. In contrast, DT induced high antibody titers able to bind with comparable avidity both the protein and its conjugates but showing very low avidity for CRM197 and related conjugates. The low intrinsic immunogenicity of CRM197 as compared to DT, the structural modifications induced by glycoconjugation and detoxification processes, resulting in conformational changes in CRM197 and DT epitopes with consequent alteration of the antibody recognition and avidity, might explain the different behavior of CRM197 and DT in a carrier priming context.

  7. 197例结核病患者检测HIV1+2型抗体结果分析%HIV1+2 Antibody Detecting Result Analysis on 197 Cases of TB

    Institute of Scientific and Technical Information of China (English)

    杨志刚

    2010-01-01

    目的 了解197例结核病患者中结核病/艾滋病(TB/HIV)双重感染情况,提高对TB/HIV双重感染检测工作的重视. 方法 对确诊登记的结核病人进行HIV抗体检测. 结果 在197例结核病患者中未发现HIV抗体检测阳性者. 结论 同仁地区是HIV感染的底流行地区,但TB/HIV双重感染控制工作非常严峻,开展这项工作意义重大,积累检测经验,发现TB/HIV双重感染者,降低TB/HIV双重感染的发病率和死亡率.

  8. Fission anisotropy of 197Tl produced in fusion reactions in the framework of the modified statistical model

    Indian Academy of Sciences (India)

    Hadi Eslamizadeh

    2015-12-01

    The anisotropy of fission fragment angular distribution, evaporation residue crosssection and the fission cross-section were calculated for 197Tl formed in 16O+181Ta reactions in the framework of the modified statistical model and the results were compared with the experimental data. The effects of temperature and projection of spin about the symmetry axis have been considered for calculating potential energy surfaces and fission widths. It was shown that in the framework of the modified statistical model, by choosing appropriate values for the temperature coefficient of the effective potential, , and scaling factor of the fission-barrier height, s, one can satisfactorily reproduce the above-mentioned experimental data. It was also shown that the appropriate values of these parameters for 197Tl are = 0.0185 ± 0.0050 MeV-2 and s = 1.0006 ± 0.0020.

  9. Measurement of the {sup 197}Au(n,{gamma}) cross section at n-TOF: towards a new standard

    Energy Technology Data Exchange (ETDEWEB)

    Massimi, C.; Abbondanno, U.; Aerts, G.; Alvarez, H.; A lvarez-Velarde, F.; Andriamonje, S.; Andrzejewski, J.; Assimakopoulos, P.; Audouin, L.; Badurek, G.; Baumann, P.; Becvar, F.; Berthoumieux, E.; Calvino, F.; Calviani, M.; Cano-Ott, D.; Capote, R.; Carrapic, C.; Cennini, P.; Chepel, V.; Chiaveri, E.; Colonna, N.; Cortes, G.; Couture, A.; Cox, J.; Dahlfors, M.; David, S.; Dillmann, I.; Domingo-Pardo, C.; Dridi, W.; Duran, I.; Eleftheriadis, C.; Embid-Segura, M.; Ferrant, L.; Ferrari, A.; Ferreira-Marques, R.; Fujii, K.; Furman, W.; Goncalves, I.; Gonzalez-Romero, E.; Gramegna, F.; Guerrero, C.; Gunsing, F.; Haas, B.; Haight, R.; Heil, M.; Herrera-Martinez, A.; Igashira, M.; Jericha, E.; Kappeler, F.; Kadi, Y.; Karadimos, D.; Karamanis, D.; Kerveno, M.; Koehler, P.; Kossionides, E.; Krticka, M.; Lampoudis, C.; Leeb, H.; Lindote, A.; Lopes, I.; Lozano, M.; Lukic, S.; Marganie, J.; Marrone, S.; Martinez, T.; Mastinu, P.; Mengoni, A.; Milazzo, P.M.; Moreau, C.; Mosconi, M.; Neves, F.; Oberhummer, H.; O' Brien, S.; Pancin, J.; Papachristodoulou, C.; Papadopoulos, C.; Paradela, C.; Patronis, N.; Pavlik, A.; Pavlopoulos, P.; Perrot, L.; Pigni, M.T.; Plag, R.; Plompen, A.; Plukis, A.; Poch, A.; Praena, J.; Pretel, C.; Quesada, J.; Rauscher, T.; Reifarth, R.; Rubbia, C.; Rudolf, G.; Rullhusen, P.; Salgado, J.; Santos, C.; Sarchiapone, L.; Savvidis, I.; Stephan, C.; Tagliente, G.; Tain, J.L.; Tassan-Got, L.; Tavora, L.; Terlizzi, R.; Vannini, G.; Vaz, P.; Ventura, A.; Villamarin, D.; Vincente, M.C.; Vlachoudis, V.; Vlastou, R.; Voss, F.; Walter, S.; Wiescher, M.; Wisshak, K

    2008-07-01

    Two different detectors and techniques are employed at n-TOF facility, at CERN, to improve the accuracy of the neutron capture cross section of {sup 197}Au(n,{gamma}): a total absorption calorimeter and a set of C{sub 6}D{sub 6}. The accurate knowledge of this cross section is of great importance for all the (n,{gamma}) reactions study. The neutron capture cross section and nuclear resonance parameters of the {sup 197}Au have been measured in the energy range of 1 eV to 1 KeV. The present work shows in average a good agreement with evaluated data libraries, although sizeable differences have been observed for some resonances. Two new resonances have also been discovered. The accuracy of the resonance partial widths has been improved and the main nuclear quantities such as the neutron strength function have been extracted. (authors)

  10. Helium projectile fragment emission in interactions of 197Au with emulsion at 10.7A GeV

    International Nuclear Information System (INIS)

    The total and partial production cross-sections of the multiple helium fragments emitted in 10.7A GeV 197Au–emulsion interactions are reported and compared with those obtained from different projectiles at high energies. The multiplicity distributions of the helium fragments exhibit a KNO scaling. The dependence of Cq moments and on the mass number of the incident beams is plotted. (author)

  11. Needle-Free Dermal Delivery of a Diphtheria Toxin CRM197 Mutant on Potassium-Doped Hydroxyapatite Microparticles.

    Science.gov (United States)

    Weissmueller, Nikolas T; Schiffter, Heiko A; Carlisle, Robert C; Rollier, Christine S; Pollard, Andrew J

    2015-05-01

    Injections with a hypodermic needle and syringe (HNS) are the current standard of care globally, but the use of needles is not without limitation. While a plethora of needle-free injection devices exist, vaccine reformulation is costly and presents a barrier to their widespread clinical application. To provide a simple, needle-free, and broad-spectrum protein antigen delivery platform, we developed novel potassium-doped hydroxyapatite (K-Hap) microparticles with improved protein loading capabilities that can provide sustained local antigen presentation and release. K-Hap showed increased protein adsorption over regular hydroxyapatite (P model antigen (CRM197) with 1% decrease in α-helix content and no change in β-sheet content upon adsorption, and sustained release in vitro. Needle-free intradermal powder inoculation with K-Hap-CRM197 induced significantly higher IgG1 geometric mean titers (GMTs) than IgG2a GMTs in a BALB/c mouse model (P 0.05), namely, alum-adsorbed CRM197 by intramuscular (i.m.) delivery. The presented results suggest that K-Hap microparticles may be used as a novel needle-free delivery vehicle for some protein antigens. PMID:25809632

  12. Measurement of isotopic cross sections of spallation residues in 800 A MeV {sup 197}Au + p collisions

    Energy Technology Data Exchange (ETDEWEB)

    Rejmund, F.; Mustapha, B.; Bernas, M.; Stephan, C.; Taieb, J.; Tassan-Got, L. [Institut de Physique Nucleaire, (IN2P3/CNRS) 91 - Orsay (France); Armbruster, P.; Benlliure, J.; Enqvist, T.; Schmidt, K.H.; Taieb, J. [GSI, Planckstrasse, Darmstadt (Germany); Benlliure, J. [Universidad de Santiago de Compostela (Spain); Boudard, A.; Legrain, R.; Leray, S.; Volant, C. [CEA/Saclay, Dept. d' Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l' Instrumentation Associee (DAPNIA), 91 - Gif-sur-Yvette (France); Dufour, J.P. [CENBG, IN2P3, 33 - Gradignan (France)

    2000-07-01

    The spallation of {sup 197}Au by 800 MeV protons was investigated in inverse kinematics at GSI, Darmstadt, by use of a {sup 197}Au beam bombarding a liquid-hydrogen target. The fragment separator (FRS) was used to select and identify the reaction products prior to {beta} decay. The individual production cross sections and the kinematical properties of 396 isotopes for all elements between mercury (Z=80) and neodymium (Z=60) have been measured. A comparison with Monte Carlo calculations based on different two-step models of the spallation reaction is given. The shape of the isotopic distributions close to the projectile is found to differ strongly from that resulting from aluminium-induced fragmentation of {sup 197}Au. The mean kinetic energies of the fragments are deduced from the experimental data. The importance of the new data to improve our understanding of the spallation mechanism and the relevance for the design of accelerator-driven sub-critical reactors is discussed. (authors)

  13. Comprehesive analysis on the histological classifications in 42 197 cases of ovarian tumors in China

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Objective:The histological types of ovarian tumors were investigated and analyzed in China in order to compare with those in other countries,which will benefit to the prevention and treatment of ovarian cancer.Methods:The pathological data from 42 197 cases of ovarian tumors in ten years during 1980 to 1989 were registered according to the WHO classification for ovarian tumors. Some indefinite cases pathologically in the first diagnosis should bereconfirmed according to the WHO classification.Results: Forty-two thousand one hundred and ninety seven cases ofovarian tumors were selected from all tumors in 21 provinces and 3 major regional cities in China.There were 10 288(24.4%) malignant tumors in all cases.They were composed by 5 650(54.9%) cases of epithelial tumors,1 871(18.2%) cases of germ cell tumors,837(8.5%) cases of sex cord tumors,1 003(9.7%) cases of secondarytumors,and 891(8.7%) cases of other tumors.The malignant tumors constituent ratios were 58.5% and 50.9% respectively in the north and south of the Yangtze River..The histological types of ovarian tumors were about the same ratios,but the malignant tumors were different in Chinese six major administrative region andalso in the region both north and south of the Yangtzy River.The ratio of borderline epithelial ovarian tumors to epithelial tumors was 1:5.9.Borderlineserous cystadenocarcnoma appeared to be similar to borderline mucinous cystadenocarcinoma in frequency.Serous cystadenocarcinoma was found to be the most frequent one in malignant epithelial tumors.Conclusion:Compared with reports abroad,the different types of malignant ovarian tumors inChina represent a different distributive pattern.The malignant epithelial ovarian tumors were lower than that in other countries (55% vs 80%-90%),while the malignant germ cell tumors and sex cord stromal tumors were 6 and 3 times higher thanthose abroad,the main metastasizing tumors come from gastroenteric carcinoma,while the metastasizing tumors from breast

  14. 40 CFR 197.15 - How must DOE take into account the changes that will occur during the period of geologic stability?

    Science.gov (United States)

    2010-07-01

    ... ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR YUCCA MOUNTAIN, NEVADA Public Health and Environmental Standards for Disposal § 197.15 How must DOE take into account the changes that will occur during the...

  15. The anti-tumor effect of cross-reacting material 197, an inhibitor of heparin-binding EGF-like growth factor, in human resistant ovarian cancer

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Xiao-han; Deng, Suo; Li, Meng [Department of Gynecology and Obstetrics, The First Affiliated Hospital of Harbin Medical University, Harbin (China); Lu, Mei-song, E-mail: lumeisong0417@163.com [Department of Gynecology and Obstetrics, The First Affiliated Hospital of Harbin Medical University, Harbin (China)

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer HB-EGF over-expression in A2780/Taxol, A2780/CDDP cells and the matched xenografts. Black-Right-Pointing-Pointer CRM197 induces enhanced apoptosis in A2780/Taxol and A2780/CDDP cells. Black-Right-Pointing-Pointer CRM197 arrests A2780/Taxol and A2780/CDDP cells at G0/G1 phase. Black-Right-Pointing-Pointer CRM197 suppressed the A2780/Taxol and A2780/CDDP growth of xenografts. -- Abstract: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for ovarian cancer therapy. Cross-reacting material 197 (CRM197), a specific HB-EGF inhibitor, has been proven to represent possible chemotherapeutic agent for ovarian cancer. However, the effect of CRM197 on the resistant ovarian carcinoma cells has not been sufficiently elucidated. Here, we found that HB-EGF was over-expressed in a paclitaxel-resistant human ovarian carcinoma cell line (A2780/Taxol) and a cisplatin-resistant cell line (A2780/CDDP), as well as the xenograft mouse tissue samples with these cells. To investigate the possible significance of the HB-EGF over-expression in A2780/Taxol and A2780/CDDP cells, we inhibited HB-EGF expression by CRM197 to investigate the effect of CRM197 treatment on these cells. We observed that CRM197 significantly induced anti-proliferative activity in a dose-dependent manner with the cell-cycle arrest at the G0/G1 phase and enhanced apoptosis in A2780/Taxol and A2780/CDDP cells. The sensitive ovarian carcinoma parental cell line (A2780), A2780/Taxol and A2780/CDDP cells formed tumors in nude mice, and enhanced tumorigenicity was observed in drug-resistant tumors. Furthermore, we observed that CRM197 significantly suppressed the growth of drug-resistant ovarian cancer xenografts in vivo (p < 0.001). These results suggest that CRM197 as an HB-EGF-targeted agent has potent anti-tumor activity in paclitaxel- and cisplatin-resistant ovarian cancer which over-express HB-EGF.

  16. Fission fragment angular distributions in proton-induced fission of 209 Bi(p,t and 197 Au(p,f

    Directory of Open Access Journals (Sweden)

    S. S.

    2001-12-01

    Full Text Available   The fission fragment angular distributions have been measured for proton-induced fission of 209Bi and 197Au nuclei using surface barrier detectors at several energies between 25 MeV and 30 MeV. The experimental anisotropies are found to be in agreement with the predictions of the Standard Saddle-Point Statistical Model (SSPSM. The fission cross sections of 209Bi 197Au nuclei were also measured and compared with the previous works.

  17. A novel c.197T ® A variant among Brazilian neonates with glucose-6-phosphate dehydrogenase deficiency

    Directory of Open Access Journals (Sweden)

    José Pereira de Moura Neto

    2008-01-01

    Full Text Available Glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49 deficiency is the most common enzyme deficiency worldwide, causing a spectrum of diseases including neonatal hyperbilirubinemia and acute or chronic hemolysis. We used the methemoglobin reduction test and G6PD electrophoresis to screen 655 neonates (354 females and 301 males for common G6PD mutations in the city of Salvador in the Northeastern Brazilian state Bahia and found that 66 (10.1% were G6PD-deficient (41 females and 25 males. The 66 (10.1% G6PD-deficient neonates were assessed for the c.376 A -> G (exon 5 and c.202 G -> A (exon 4 mutations using the polymerase chain reaction and restriction enzyme fragment length polymorphism (PCR-RFLP analysis and the results validated by DNA sequencing. Of the 66 G6PD-deficient neonates investigated we found that 54 (81.8% presented the c.376 A -> G (p.Asn126Asp and c.202 G -> A (p.Val68Met mutations, two (3% had the c.376 A -> G mutation only, two (3% had the c.202 G -> A mutation only, five (7.6% exhibited a previously unrecorded 197T -> A (p.Phe66Thr substitution in exon 4 and three showed no mutations at any of these sites. Of the five neonates exhibiting the new 197T -> A (p.Phe66Thr substitution, four (6.1% also presented the c.202 G -> A and c.376 A -> G mutations and one (1.5% had the c.[197T -> A / 202 G -> A] combination. We propose to name the new variant G6PD Bahia.

  18. Isotopic Distributions of the l8N Fragmentation Products in Coincidence with Neutrons on Targets 197Au and 9Be

    Institute of Scientific and Technical Information of China (English)

    李湘庆; 江栋兴; 叶沿林; 华辉; 陈陶; 李智焕; 葛愉成; 王全进; 吴和宇; 靳根明; 段利敏; 肖志刚; 王宏伟; 李祖玉; 王素芳

    2002-01-01

    We present the experimental isotopic distributions of the 18 N projectile fragmentation products Li, Be,B and Cin coincidence with neutrons, as well as the inclusive ones on 197 Au and 9Be targets. In the framework of theabrasion-ablation model, these distributions are calculated for various nucleon density distributions of the projec-tile. The comparison with experimental isotopic distributions of the projectile-like fragments in coincidence withneutrons shows that the information on the nucleon density distribution of the 18N projectile can be extracted.

  19. Results of time-of-flight transmission measurements for 197Au at a 50 m station of GELINA

    OpenAIRE

    Kopecky, Stefan; BECKER BJÖRN; DROHE Jean Claude; OTUKA N.; Schillebeeckx, Peter; VENDELBO Danny; WYNANTS Ruud

    2013-01-01

    Transmission measurements have been performed at the time-of-flight facility GELINA to determine the total cross section for neutron induced reactions in 197Au. The measurements have been carried out at a 50 m transmission station of GELINA with the accelerator operating at 800 Hz. This report provides the experimental details required to deliver the data to the EXFOR data library which is maintained by the Nuclear Data Section of the IAEA and the Nuclear Energy Agency of the OECD. The experi...

  20. Fragment-fragment correlations in the 4.8 GeV {sup 3}He + {sup 197}Au system

    Energy Technology Data Exchange (ETDEWEB)

    Kwiatkowski, K.; Wang, G.; Morley, K.B.; Bracken, D.S. [and others

    1995-10-01

    Both small- and large-angle IMF-IMF correlations have been investigated for the multifragmentation events from the 4.8 GeV {sup 3}He + {sup 197}Au reaction. Relative velocities are found to depend on fragment charge, but to be only weakly sensitive to IMF multiplicity. The large-angle data are compared with predictions of simulations based on sequential statistical evaporation, an expanding evaporating source and statistical multifragmentation models. The Coulomb hole in the small angle correlations is examined to estimate the multifragmentation time scale.

  1. Multifragmentation in the 4.8-GeV 3He+ natAg, 197Au reactions

    International Nuclear Information System (INIS)

    Multifragmentation of natAg and 197Au nuclei induced by a 4.8-GeV 3He ions has been studied with the Indiana Silicon Sphere 4π detector array. Rapidity and moving source analyses are consistent with thermal emission from a source in approximate kinetic equilibrium. For the most dissipative collisions, the spectral Coulomb peaks are broadened to very low energies, indicative of emission from an extended nuclear system. Predictions of a model with an intranuclear cascade and an expanding, emitting source compare well with experimental multiplicity distributions and the evolution of fragment spectral shapes

  2. Multifragmentation in the 4.8-GeV {sup 3}He+ {sup nat}Ag, {sup 197}Au reactions

    Energy Technology Data Exchange (ETDEWEB)

    Kwiatkowski, K.; Morley, K.B.; Foxford, E.R.; Bracken, D.S.; Viola, V.E.; Yoder, N.R.; Legrain, R.; Pollacco, E.C.; Volant, C.; Friedman, W.A.; Korteling, R.G.; Brzychczyk, J.; Breuer, H. [Department of Chemistry and Physics and IUCF, Indiana University, Bloomington, Indiana 47405 (United States)]|[Commissariat a l`Energie Atomique DAPNIA/Service de Physique des Particles, Centre d`Etudes de Saclay, 91191 Gif-sur-Yvette Cedex (France)]|[Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1SG (Canada)]|[Department of Physics, University of Wisconsin, Madison, Wisconsin 53706 (United States)]|[Institute of Physics, Jagiellonian University, 30-059 Krakow (Poland)]|[Department of Physics, University of Maryland, College Park, Maryland 20742 (United States)

    1995-05-08

    Multifragmentation of {sup nat}Ag and {sup 197}Au nuclei induced by a 4.8-GeV {sup 3}He ions has been studied with the Indiana Silicon Sphere 4{pi} detector array. Rapidity and moving source analyses are consistent with thermal emission from a source in approximate kinetic equilibrium. For the most dissipative collisions, the spectral Coulomb peaks are broadened to very low energies, indicative of emission from an extended nuclear system. Predictions of a model with an intranuclear cascade and an expanding, emitting source compare well with experimental multiplicity distributions and the evolution of fragment spectral shapes.

  3. Fragment-fragment correlations in the 4.8 GeV 3He + 197Au system

    International Nuclear Information System (INIS)

    Both small- and large-angle IMF-IMF correlations have been investigated for the multifragmentation events from the 4.8 GeV 3He + 197Au reaction. Relative velocities are found to depend on fragment charge, but to be only weakly sensitive to IMF multiplicity. The large-angle data are compared with predictions of simulations based on sequential statistical evaporation, an expanding evaporating source and statistical multifragmentation models. The Coulomb hole in the small angle correlations is examined to estimate the multifragmentation time scale

  4. Radiation damage in single crystal CVD diamond material investigated with a high current relativistic 197Au beam

    International Nuclear Information System (INIS)

    Single-crystal Chemical Vapor Deposition (ScCVD) diamond based prototype detectors have been constructed for the high intensity heavy ion experiments HADES and CBM at the future FAIR facility at GSI Darmstadt. Their properties have been studied with a high current density beam (about 2–3×106/s/mm2) of 1.25A GeV 197Au69+ ions. Details of the design, the intrinsic properties of the detectors and their performance after irradiation with such a beam are reported

  5. 197Au Moessbauer study of the deactivation and reactivation of a carbon-supported AuCl4- hydrochlorination catalyst

    International Nuclear Information System (INIS)

    Acetylene hydrochlorination catalysts consisting of activated carbon impregnated with a solution of HAuCl4.xH2O in aqua regia have been studied by 197Au Moessbauer spectroscopy. The relative amounts of AuCl4-, of Au(0), and of an Au(I) species formed under certain process conditions were determined quantitatively. Deactivation of the catalyst at low and high temperatures was shown to be due to different mechanisms, and the reactivation of the catalyst by Cl2 gas was studied. (orig.)

  6. Emission geometry, radiation pattern, and magnetic topology of the magnetar XTE J1810-197 in its quiescent state

    CERN Document Server

    Bernardini, Federico; Gotthelf, Eric; Israel, Gian Luca; Rea, Nanda; Stella, Luigi

    2011-01-01

    The return to the quiescent state of the Anomalous X-ray pulsar XTE J1810-197 following its 2003 outburst represents a unique opportunity to probe the surface emission properties of a magnetar. The quiescent emission of XTE J1810-197 is composed of two thermal components, one arising from the whole star surface, and the other from a small warm spot on it. By modeling the magnitude and shape of the pulse profile in narrow spectral bands, we have been able to constrain the physical characteristics and geometrical parameters of the system: the two angles that the line of sight and the spin axis make with respect to the warm spot axis (\\psi\\ and \\xi\\ respectively), the angular size of the spot, and the overall surface temperature distribution. Our modeling accounts for the general relativistic effects of gravitational redshift and light bending near the stellar surface, and allows for local anisotropic emission. We found that the surface temperature distribution on the neutron star is consistent with the expectat...

  7. Simulations of dynamic pion production in 60 and 200 GeV collisions of 16O + 197Au

    International Nuclear Information System (INIS)

    The authors have investigated collision of 16O with 197Au at bombarding energies of 60 and 200 GeV/N in the laboratory frame. Their hydrodynamics-based 3-D model, with a modified gamma-law equation of state, includes detailed dynamic pion production and propagation. A comparison of hydrodynamic simulations with and without the inclusion of pions shows that including the pion channel yields results which more closely reproduce the experimental data. The authors show direct comparisons of several predicted observables with experimental measurements made over various pseudorapidity ranges. In general, they find that while their overall energy agreement with calorimetry experiments is good, and their predicted spatial distributions are in fair agreement with experimental data, their model produces pions which are to energetic and too few in balancing proportions. The authors results indicate that most of the emitted (measured) pions emerge from the cooler surface, and not from the hot, dense interior of the hadronic composite

  8. Residue excitation functions from complete fusion of [sup 16]O with [sup 197]Au and [sup 208]Pb

    Energy Technology Data Exchange (ETDEWEB)

    Brinkmann, K.; Caraley, A.L.; Fineman, B.J.; Gan, N.; Velkovska, J.; McGrath, R.L. (Physics Department, State University of New York at Stony Brook, Stony Brook, New York 11794 (United States))

    1994-07-01

    Evaporation residue excitation functions and [alpha]-multiplicities from complete fusion of [sup 16]O with [sup 197]Au and [sup 208]Pb have been measured from the fusion threshold up to 140 MeV incident energy. The data allow the conclusion that strongly overdamped motion cannot be dominant at energies in the vicinity of the fusion barrier below [ital E][sup *][approx]50 MeV. At excitation energies above 50 MeV the residue cross section for [sup 16]O+[sup 208]Pb is much greater than predicted from the statistical model with conventional parametrizations. The enhancement is not explained by incorporating dynamical effects into the analysis. An alternative suggestion based on deexcitation-chain dependent fission barriers is discussed.

  9. Evaporation residue cross sections from complete fusion of {sup 16}O with {sup 197}Au, {sup 208}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Brinkmann, K.T.; Caraley, A.L.; Fineman, B.J. [and others

    1993-04-01

    Fusion-evaporation excitation functions for complete fusion of {sup 16}O with {sup 197}Au and {sup 208}Pb have been measured from the barrier up to excitation energies of about 100 MeV. Using the pulsed {sup 16}O beam from the Stony Brook LINAC, the very slow evaporation residues (ER`s) were separated in an electrostatic deflector system and identified in an array of three surface barrier detectors by their time of flight and energy. While the ER cross sections in the vicinity of the fusion barrier allow the extraction of important statistical model parameters such as fission barrier heights, data at higher excitation energies can yield insight into processes beyond the statistical model regime. The results will be discussed with respect to both aspects.

  10. Enhanced inhibition of murine prostatic carcinoma growth by immunization with or administration of viable human umbilical vein endothelial cells and CRM197

    Directory of Open Access Journals (Sweden)

    Zhang Huiyong

    2011-02-01

    Full Text Available Vaccination with xenogeneic and syngeneic endothelial cells is effective for inhibiting tumor growth. Nontoxic diphtheria toxin (CRM197, as an immunogen or as a specific inhibitor of heparin-binding EGF-like growth factor, has shown promising antitumor activity. Therefore, immunization with or administration of viable human umbilical vein endothelial cells (HUVECs combined with CRM197 could have an enhanced antitumor effect. Six-week-old C57BL/6J male mice were vaccinated with viable HUVECs, 1 x 10(6 viable HUVECs combined with 100 μg CRM197, or 100 μg CRM197 alone by ip injections once a week for 4 consecutive weeks. RM-1 cells (5 x 10(5 were inoculated by sc injection as a preventive procedure. During the therapeutic procedure, 6-week-old male C57BL/6J mice were challenged with 1 x 10(5 RM-1 cells, then injected sc with 1 x 10(6 viable HUVECs, 1 x 10(6 viable HUVECs + 100 μg CRM197, and 100 μg CRM197 alone twice a week for 4 consecutive weeks. Tumor volume and life span were monitored. We also investigated the effects of immunization with HUVECs on the aortic arch wall and on wound healing. Vaccination with or administration of viable HUVECs+CRM197 enhanced the inhibition of RM-1 prostatic carcinoma by 24 and 29%, respectively, and prolonged the life span for 3 and 4 days, respectively, compared with those of only vaccination or administration with viable HUVECs of tumor-bearing C57BL/6J mice. Furthermore, HUVEC immunization caused some damage to the aortic arch wall but did not have remarkable effects on the rate of wound healing; the wounds healed in approximately 13 days. Treatment with CRM197 in combination with viable HUVECs resulted in a marked enhancement of the antitumor effect in the preventive or therapeutic treatment for prostatic carcinoma in vivo, suggesting a novel combination for anti-cancer therapy.

  11. 2.4-197 mu m spectroscopy of OH/IR stars : the IR characteristics of circumstellar dust in O-rich environments

    NARCIS (Netherlands)

    Sylvester, RJ; Kemper, F; Barlow, MJ; de Jong, T; Waters, LBFM; Tielens, AGGM; Omont, A

    1999-01-01

    Infrared spectra of a number of evolved O-rich stars have been obtained with the Short- and Long-Wavelength spectrometers on board the Infrared Space Observatory. The very broad wavelength coverage (2.4-197 mu m) obtained by combining observations made with the two spectrometers includes practically

  12. Breakup of 42 MeV 7Li projectiles in the fields of 12C and 197Au nuclei

    Indian Academy of Sciences (India)

    Dhruba Gupta; C Samanta; R Kanungo; P Basu; Subinit Roy; S Kailas; A Chatterjee; B J Roy; K Mahata; A Samant; A Shrivastava

    2001-07-01

    Inclusive cross sections of particles and tritons from the breakup of 42 MeV 7Li by 12C and 197Au targets are presented and analysed in the framework of the Serber model. Spectral distortions due to the targets and relevant reaction mechanisms are discussed.

  13. Proton-induced fission at 190 MeV of W-nat, Au-197, Pb-nat, Pb-208, and Th-232

    NARCIS (Netherlands)

    Duijvestijn, MC; Koning, AJ; Beijers, JPM; Gastal, M; van Klinken, J; Ostendorf, RW

    1999-01-01

    Proton-induced fission at 190 MeV of W-nat, Au-197, Pb-nat, Pb-208, and Th-232 is studied by means of an innovative method based on activation analysis. The fission-product mass distribution is reconstructed from the fission-product yields, which are obtained from off-line observed gamma-ray spectra

  14. Catalytic residues Lys197 and Arg199 of Bacillus subtilis phosphoribosyl diphosphate synthase. Alanine-scanning mutagenesis of the flexible catalytic loop

    DEFF Research Database (Denmark)

    Hove-Jensen, Bjarne; Bentsen, Ann-Kristin K; Harlow, Kenneth W

    2005-01-01

    Eleven of the codons specifying the amino acids of the flexible catalytic loop [KRRPRPNVAEVM(197-208)] of Bacillus subtilis phosphoribosyl diphosphate synthase have been changed individually to specify alanine. The resulting variant enzyme forms, as well as the wildtype enzyme, were produced in a...

  15. Mass and charge flow in the reaction 7.1 MeV/u197Au+63Cu

    Science.gov (United States)

    Jäckel, B.; Rox, A.; Esterlund, R. A.; Westmeier, W.; Knaack, M.; Patzelt, P.

    1991-12-01

    Mass-yield and angular-distribution data are presented for products from the reaction of 7.1 MeV/ μ 197Au with63Cu. With help from information derived from the latter, the former are classified into components corresponding to quasielastic transfer (580±80 mb), deep-inelastic transfer plus quasifission (1300±130 mb), fusionfission (≦195 mb), and sequential fission (195±45 mb). The fusion excitation function calculated with the Dynamic Capture model standard parameter set reproduces our deduced fusion-fission cross section well. Moreover, using this cross section as well as additional published data for the same reaction system, we extract an s-wave fusion-barrier shift (“extra push”) for this system of 35±7 MeV, which is in good agreement with the systematics derived from other fusion-barrier shifts which have been reported in the literature. Lastly, support is found for the Dissipative Diabatic Dynamics model prediction that dynamically-hindered fusion trajectories are reflected into quasielastic channels.

  16. Long-Term Spectral and Temporal Evolution of Anomalous X-Ray Pulsar XTE J1810-197

    Science.gov (United States)

    Vurgun, Eda; Gogus, Ersin; Chakraborty, Manoneeta; Guver, Tolga

    2016-07-01

    We present spectral and timing studies of the first transient Anomalous X-ray Pulsar XTE J1810-197, a 5.54 s pulsar discovered in 2003, when its X-ray luminosity increased ~100 fold. We investigate the long-term behaviour of the surface temperature,emitting area, and the pulsed fraction. X-ray spectra are well fitted by a two-component blackbody model in which the cool component is most likely arising from the whole surface of star and the hot component is arising from a relatively small hot spot on it. The spectral analysis has also shown evidence for the presence of an absorbtion line feature around 1.2 keV in almost all observations. We fit this absorption feature with an asymmetric gaussian component since it shows an asymmetric structure. The pulse fraction exhibits slightly different temporal evolution in higher and lower energy bands. We will discuss correlative behaviour between the spectral and timing parameters in order to constrain magnetar cooling models.

  17. miRNA-197 and miRNA-223 Predict Cardiovascular Death in a Cohort of Patients with Symptomatic Coronary Artery Disease.

    Directory of Open Access Journals (Sweden)

    Christian Schulte

    Full Text Available Circulating microRNAs (miRNAs have been described as potential diagnostic biomarkers in cardiovascular disease and in particular, coronary artery disease (CAD. Few studies were undertaken to perform analyses with regard to risk stratification of future cardiovascular events. miR-126, miR-197 and miR-223 are involved in endovascular inflammation and platelet activation and have been described as biomarkers in the diagnosis of CAD. They were identified in a prospective study in relation to future myocardial infarction.The aim of our study was to further evaluate the prognostic value of these miRNAs in a large prospective cohort of patients with documented CAD.Levels of miR-126, miR-197 and miR-223 were evaluated in serum samples of 873 CAD patients with respect to the endpoint cardiovascular death. miRNA quantification was performed using real time polymerase chain reaction (RT-qPCR.The median follow-up period was 4 years (IQR 2.78-5.04. The median age of all patients was 64 years (IQR 57-69 with 80.2% males. 38.9% of the patients presented with acute coronary syndrome (ACS, 61.1% were diagnosed with stable angina pectoris (SAP. Elevated levels of miRNA-197 and miRNA-223 reliably predicted future cardiovascular death in the overall group (miRNA-197: hazard ratio (HR 1.77 per one standard deviation (SD increase (95% confidence interval (CI 1.20; 2.60, p = 0.004, C-index 0.78; miRNA-223: HR 2.23 per one SD increase (1.20; 4.14, p = 0.011, C-index 0.80. In ACS patients the prognostic power of both miRNAs was even higher (miRNA-197: HR 2.24 per one SD increase (1.25; 4.01, p = 0.006, C-index 0.89; miRA-223: HR 4.94 per one SD increase (1.42; 17.20, p = 0.012, C-index 0.89.Serum-derived circulating miRNA-197 and miRNA-223 were identified as predictors for cardiovascular death in a large patient cohort with CAD. These results reinforce the assumption that circulating miRNAs are promising biomarkers with prognostic value with respect to future

  18. Study on Safety and Immunogenicity of Haemophilus Influenzae Type b Conjugate Vaccine (Polyribosylribitol Phosphate-Cross Reacting Material 197)%b型流行性感冒嗜血杆菌结合疫苗(磷酸多核糖基核糖醇-白喉毒素突变体197)的安全性和免疫原性研究

    Institute of Scientific and Technical Information of China (English)

    赵玉良; 张建立; 陈玉国; 马景臣; 郝志勇; 王志国; 张志勇; 刘金凤

    2013-01-01

    Objective To evaluate the safety,immunogenicity and booster effect of a Haemophilus influenzae type b (Hib) conjugated vaccine (polyribosylribitol phosphate-cross reacting material 197,PRP-CRM197) against Hib for Chinese children,Methods The Hib PRP-CRM197 was evaluated in three trials.The first (phase Ⅰ) safety study were conducted in two Firstly,20 toddlers aged 16-20 months were enrolled and received one dose of PRP-CRM197 vaccine; 15 days later,20 infants aged 2-4 months were enrolled and received 3 doses of PRP-CRM197 vaccine with 1 months interval.Safety data only were collected up to 30 days post each dose of vaccination.The second trial,a phase Ⅲ study,primary immunization enrolled randomly 916 subjects who were the age of 2-4 months to receive either PRP-CRM197 (N=611) or PRP-T (tetanus toxoid) vaccine as control group (N=305) administered three doses with one month interval.In a third (phase Ⅲ)trial,booster immunization,the subjects received a booster dose of vaccine for toddlers (12 to 18 months of age)after completed 3 doses.In the phase Ⅲ studies,safety and immunogenicity data were collected.The immunogenicity was measured via anti-PRP enzyme-linked immunosorbant assay.Results The safety study of phase Ⅰ found that the PRP-CRM197 was well tolerated in both age groups (infants and toddlers).The trial of phase Ⅲ for three-dose primary immunization schedule and booster dose demonstrated the safety of PRP-CRM197 are similar to that of PRP-T.All subjects achieved short-term seroprotective anti-PRP antibody levels (≥ 0.15μg/ml) following primary immunization with two kind of vaccines; 99% and 97% of subjects achieved long-term (≥ 1.0μg/ml) seroprotection in the PRP-CRM197 and PRP-T vaccine groups respectively,one month after completion of the primary vaccination series.All subjects receiving booster mmunization among trial group and control group got short-term and long-term seroprotective antibody.Administration of PRP-CRM197

  19. 4{pi} studies of the 1.8-4.8 GeV {sup 3}He+{sup nat}Ag, {sup 197}Au reactions. I. Energy deposition

    Energy Technology Data Exchange (ETDEWEB)

    Morley, K.B.; Kwiatkowski, K.; Bracken, D.S.; Renshaw Foxford, E. [Indiana Univ., Bloomington, IN (United States). Dept. of Chemistry; Legrain, R.; Pollacco, E.C.; Volant, C. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l`Instrumentation Associee; Korteling, R.G. [Simon Fraser Univ., Burnaby, BC (Canada). Dept. of Chemistry; Breuer, H. [Maryland Univ., College Park, MD (United States). Dept. of Physics; Brzychczyk, J. [Jagellonian Univ., Krakow (Poland). Inst. of Physics

    1996-01-01

    The 4{pi} detector ISiS has been used to measure light-charged particles and intermediate-mass-fragments emitted in the 1.8-4.8 GeV {sup 3}He+{sup nat}Ag, {sup 197}Au reactions. Ejectile multiplicity and total event kinetic energy distribution scale systematically with projectile energy and target mass, except for the {sup nat}Ag target at 3.6 and 4.8 GeV. For this system, a saturation in deposition energy is indicated by the data, suggesting the upper projectile energy for stopping has been reached. Maximum deposition energies of {approx}950 MeV for the {sup nat}Ag target and {approx}1600 MeV for the {sup 197}Au target are inferred from the data. Comparison of the experimental distributions with intranuclear cascade predictions shows qualitative agreement. (author). Submitted to Physical Review, C (US); 46 refs.

  20. The clinical relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer.

    Science.gov (United States)

    Fujita, Yu; Yagishita, Shigehiro; Hagiwara, Keitaro; Yoshioka, Yusuke; Kosaka, Nobuyoshi; Takeshita, Fumitaka; Fujiwara, Tomohiro; Tsuta, Koji; Nokihara, Hiroshi; Tamura, Tomohide; Asamura, Hisao; Kawaishi, Makoto; Kuwano, Kazuyoshi; Ochiya, Takahiro

    2015-04-01

    Programmed cell death ligand-1 (PD-L1) has recently gained considerable attention for its role in tumor immune escape. Here, we identify a miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer (NSCLC), independent of immunoinhibitory signals. miR-197 is downregulated in platinum-resistant NSCLC specimens, resulting in the promotion of chemoresistance, tumorigenicity, and pulmonary metastasis in vitro and in vivo. Mechanistic investigations reveal that a miR-197-mediated CKS1B/STAT3 axis exerts tumor progression regulated by various oncogenic genes (Bcl-2, c-Myc, and cyclin D1), and PD-L1 is a putative biomarker of this axis. Furthermore, we demonstrate that a miR-197 mimic sensitizes PD-L1(high) drug-resistant cells to chemotherapy. These results indicate that the biological interaction between PD-L1 and chemoresistance occurs through the microRNA regulatory cascade. More importantly, expression levels of miR-197 are inversely correlated with PD-L1 expression (n = 177; P = 0.026) and are associated with worse overall survival (P = 0.015). Our discoveries suggest that the miR-197/CKS1B/STAT3-mediated network can drive tumor PD-L1 expression as a biomarker of this cascade, and miR-197 replacement therapy may be a potential treatment strategy for chemoresistant NSCLC. PMID:25597412

  1. Two-particle rapidity correlations between relativistic particles in central collisions of {sup 197}Au nuclei in emulsion at 11.6 A GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Abdurakhmanov, U.U.; Gulamov, K.G.; Navotny, V.Sh. [Fizika-Solntse Research and Production Association, Uzbek Academy of Sciences, Institute for Physics and Technology, Tashkent (Uzbekistan)

    2016-06-15

    It is shown that in central collisions of {sup 197}Au nuclei with heavy emulsion nuclei at 11.6 AGeV/c two-particles pseudorapidity correlations for produced particles in terms of correlation functions demonstrate predominantly long-range behaviour in contrast to nucleon-nucleon interactions. The experimental data are compared with calculations based on the FRITIOF-M model and the model of independent emission of particles. (orig.)

  2. The sustainability of quinoa production in Southern Bolivia : from misrepresentations to questionable solutions. Comments on Jacobsen (2011, J. Agron. Crop Sci. 197: 390-399)

    OpenAIRE

    Winkel, Thierry; Bertero, H. D.; Van Bommel, P.; Bourliaud, J.; Lazo, M. C.; Cortes, G.; Gasselin, P.; Geerts, S; Joffre, R; Leger, F.; Avisa, B. M.; S. Rambal; Rivière, G.; Tichit, M.; Tourrand, J.F.

    2012-01-01

    Reviewing the situation of quinoa production in southern Bolivia, Jacobsen (2011, J. Agron. Crop Sci. 197: 390) argues that the booming export market has a negative effect on the environment and on the home consumption of quinoa, thereby leading to an environmental disaster in the region. In view of the scarcity of scientific knowledge on the rapid social and environmental dynamics in the region, we consider that Jacobsens review misrepresents the situation of quinoa production in southern Bo...

  3. The quadrupole moments of 195-197Ausup(m)(11/2) and the low temperature thermal relaxation of gold in cadmium

    International Nuclear Information System (INIS)

    sup(195, 197m)Hg has been oriented at low temperature in a cadmium single crystal. From the orientation pattern of the 388 keV gamma ray Vsub(zz)(HgCd) = +1.82(25)x1018 V/cm2 has been deduced. Using the dipole-relaxation mechanism on the gold isomeric state, the relaxation constant Csub(K) = 0.044(5)Ks, the quadrupole interaction frequencies γsub(Q)(195m-AuCd) = +395(18) MHz, γsub(Q)(197m-AuCd) = +380(58) MHz and delta(E2/M1 ; 261 keV) < 0 are obtained from the orientation pattern of the 261 and 279 keV gamma rays. Using literature electric field gradient of gold in cadmium, Q(195m-Au,11/2) = (+)1.41(10) b and Q(197m-Au,11/2) = (+)1.35(22) b can be deduced. (Auth.)

  4. Gold nanoparticles production using reactor and cyclotron based methods in assessment of (196,198)Au production yields by (197)Au neutron absorption for therapeutic purposes.

    Science.gov (United States)

    Khorshidi, Abdollah

    2016-11-01

    Medical nano-gold radioisotopes is produced regularly using high-flux nuclear reactors, and an accelerator-driven neutron activator can turn out higher yield of (197)Au(n,γ)(196,198)Au reactions. Here, nano-gold production via radiative/neutron capture was investigated using irradiated Tehran Research Reactor flux and also simulated proton beam of Karaj cyclotron in Iran. (197)Au nano-solution, including 20nm shaped spherical gold and water, was irradiated under Tehran reactor flux at 2.5E+13n/cm(2)/s for (196,198)Au activity and production yield estimations. Meanwhile, the yield was examined using 30MeV proton beam of Karaj cyclotron via simulated new neutron activator containing beryllium target, bismuth moderator around the target, and also PbF2 reflector enclosed the moderator region. Transmutation in (197)Au nano-solution samples were explored at 15 and 25cm distances from the target. The neutron flux behavior inside the water and bismuth moderators was investigated for nano-gold particles transmutation. The transport of fast neutrons inside bismuth material as heavy nuclei with a lesser lethargy can be contributed in enhanced nano-gold transmutation with long duration time than the water moderator in reactor-based method. Cyclotron-driven production of βeta-emitting radioisotopes for brachytherapy applications can complete the nano-gold production technology as a safer approach as compared to the reactor-based method. PMID:27524041

  5. Methodological considerations regarding the use of inorganic 197Hg(II) radiotracer to assess mercury methylation potential rates in lake sediment.

    Science.gov (United States)

    Pérez Catán, Soledad; Guevara, Sergio Ribeiro; Marvin-DiPasquale, Mark; Magnavacca, Cecilia; Cohen, Isaac Marcos; Arribere, María

    2007-09-01

    Methodological considerations on the determination of benthic methyl-mercury (CH(3)Hg) production potentials were investigated on lake sediment, using (197)Hg radiotracer. Three methods to arrest bacterial activity were compared: flash freezing, thermal sterilization, and gamma-irradiation. Flash freezing showed similar CH(3)Hg recoveries as thermal sterilization, which was both 50% higher than the recoveries obtained with gamma-ray irradiation. No additional radiolabel was recovered in kill-control samples after an additional 24 or 65 h of incubation, suggesting that all treatments were effective at arresting Hg(II)-methylating bacterial activity, and that the initial recoveries are likely due to non-methylated (197)Hg(II) carry-over in the organic extraction and/or [(197)Hg]CH(3)Hg produced via abiotic reactions. Two CH(3)Hg extraction methods from sediment were compared: (a) direct extraction into toluene after sediment leaching with CuSO(4) and HCl and (b) the same extraction with an additional back-extraction step to thiosulphate. Similar information was obtained with both methods, but the low efficiency observed and the extra work associated with the back-extraction procedure represent significant disadvantages, even tough the direct extraction involves higher Hg(II) carry over.

  6. Lack of Association of the Polymorphisms IL-17A (−197G/A and IL-17F (+7488A/G with Multibacillary Leprosy in Mexican Patients

    Directory of Open Access Journals (Sweden)

    Mónica Escamilla-Tilch

    2014-01-01

    Full Text Available Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the IL-17A G-197A (rs227593 and IL-17F A7488G (His161Arg, rs763780 gene SNPs and susceptibility to leprosy disease in Mexican population. Methods. Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique. Results. We found nonsignificant differences in genotype and allele frequencies related to IL-17A G-197A (rs227593 and IL-17F A7488G (His161Arg, rs763780 gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals. Conclusions. Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of IL-17A G-197A (rs227593 and IL-17F A7488G (His161Arg, rs763780, suggesting that IL-17 polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population.

  7. Methodological considerations regarding the use of inorganic {sup 197}Hg(II) radiotracer to assess mercury methylation potential rates in lake sediment

    Energy Technology Data Exchange (ETDEWEB)

    Perez Catan, Soledad [Laboratorio de Analisis por Activacion Neutronica, Comision Nacional de Energia Atomica, Centro Atomico Bariloche, 8400 Bariloche (Argentina); Guevara, Sergio Ribeiro [Laboratorio de Analisis por Activacion Neutronica, Comision Nacional de Energia Atomica, Centro Atomico Bariloche, 8400 Bariloche (Argentina)], E-mail: ribeiro@cab.cnea.gov.ar; Marvin-DiPasquale, Mark [US Geological Survey, 345 Middlefield Rd./MS 480, Menlo Park, CA 94025 (United States); Magnavacca, Cecilia [Centro Atomico Ezeiza, Comision Nacional de Energia Atomica, Presbitero Gonzalez y Aragon No. 15, B1802AYA, Ezeiza, Buenos Aires (Argentina); Cohen, Isaac Marcos [Departamento de Ingenieria Quimica, Facultad Regional Buenos Aires, Universidad Tecnologica Nacional, Medrano 951 (C1179AAQ) Buenos Aires (Argentina); Arribere, Maria [Laboratorio de Analisis por Activacion Neutronica, Comision Nacional de Energia Atomica, Centro Atomico Bariloche, 8400 Bariloche (Argentina)

    2007-09-15

    Methodological considerations on the determination of benthic methyl-mercury (CH{sub 3}Hg) production potentials were investigated on lake sediment, using {sup 197}Hg radiotracer. Three methods to arrest bacterial activity were compared: flash freezing, thermal sterilization, and {gamma}-irradiation. Flash freezing showed similar CH{sub 3}Hg recoveries as thermal sterilization, which was both 50% higher than the recoveries obtained with {gamma}-ray irradiation. No additional radiolabel was recovered in kill-control samples after an additional 24 or 65 h of incubation, suggesting that all treatments were effective at arresting Hg(II)-methylating bacterial activity, and that the initial recoveries are likely due to non-methylated {sup 197}Hg(II) carry-over in the organic extraction and/or [{sup 197}Hg]CH{sub 3}Hg produced via abiotic reactions. Two CH{sub 3}Hg extraction methods from sediment were compared: (a) direct extraction into toluene after sediment leaching with CuSO{sub 4} and HCl and (b) the same extraction with an additional back-extraction step to thiosulphate. Similar information was obtained with both methods, but the low efficiency observed and the extra work associated with the back-extraction procedure represent significant disadvantages, even tough the direct extraction involves higher Hg(II) carry over.

  8. Physical and underway data collected aboard the KNORR during cruise KN197-08 in the Caribbean Sea and North Atlantic Ocean from 2010-05-22 to 2010-06-24 (NODC Accession 0104289)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC accession 0104289 includes physical and underway data collected aboard the KNORR during cruise KN197-08 in the Caribbean Sea and North Atlantic Ocean from...

  9. Physical and underway data collected aboard the KNORR during cruise KN197-04 in the North Atlantic Ocean and South Atlantic Ocean from 2010-02-19 to 2010-03-12 (NODC Accession 0104286)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC accession 0104286 includes physical and underway data collected aboard the KNORR during cruise KN197-04 in the North Atlantic Ocean and South Atlantic Ocean...

  10. Physical and underway data collected aboard the KNORR during cruise KN197-10 in the North Atlantic Ocean from 2010-07-10 to 2010-08-01 (NODC Accession 0104293)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NODC accession 0104293 includes physical and underway data collected aboard the KNORR during cruise KN197-10 in the North Atlantic Ocean from 2010-07-10 to...

  11. Effect of concrete buildings on the environmental neutron flux by using the reaction 197Au (n,γ) 198Au and extremely low level gamma ray spectroscopy

    Institute of Scientific and Technical Information of China (English)

    K. KOMURA; N.K. AHMED; A.H. EL-KAMEL; A.M.M. YOUSEF

    2004-01-01

    The activation of gold by environmental neutrons through the reaction 197Au (n,γ) 198Au was used to study the effect of concrete buildings on the neutron flux, and to estimate the thermal neutron flux inside and outside these buildings. The results showed that three ceilings of thickness 34 g/cm2 decrease the fast neutrons to 26% from its original value. However, the same reinforced concrete decreases the slow neturon flux to only 62% of its original value. The thermal neutron flux at 283 m from the center of Training Reactor of Kinki University, was twice higher than the environmental neutron background.

  12. Study of the correlations between intermediate mass fragments in the 86Kr + 197 Au reaction at 43 MeV/nucleon

    International Nuclear Information System (INIS)

    The different reaction mechanisms occurring in the 86Kr and 197 Au reaction, at 43 MeV/nucleon, are studied. The experiment is performed in an experimental device using, for the first time, three (among four) multidetectors available at Nautilus. The reaction crocs section is obtained. The investigation on the fragments coincidence allowed to show different components in the velocity correlation spectra. The reaction main characteristics are given. The simultaneous analysis of the quasi-projectile and the fragment(s), having intermediate velocities, showed the coexistence of different reaction mechanisms

  13. Comparative study of fixation of Co57 labelled bleomycin, labelled gallium citrate and Hg197 labelled mercury chloride, benign or malignant pulmonary lesions

    International Nuclear Information System (INIS)

    Over the last ten years, numerous labelled molecules have been used in lung diseases, in order to attempt definite localisation of primary or secondary carcinoma. Three of these substances are now used: cobalt 57-labelled bleomycin, Hg197Cl2 and Ga67 citrate. A study of 34 patient with malignant or tuberculous lung disease with definite diagnosis, permitted demonstration of the fact that the highest uptake, or the best images, were obtained with labelled bleomycin. However, the long period of Co57 limits its indications in young subjects and, in these cases, HgCl2 is indicated

  14. A 1.97 μm multiwavelength thulium-doped silica fiber laser based on a nonlinear amplifier loop mirror

    International Nuclear Information System (INIS)

    A 1.97 μm multiwavelength Tm-doped fiber laser based on a nonlinear amplifier loop mirror (NALM) has been experimentally demonstrated. The NALM with 500 m standard single mode fiber introduces intensity-dependent gain to alleviate mode competition caused by homogeneous gain broadening in Tm-doped fibers. At room temperature, up to 42 wavelengths with a wavelength spacing of 0.33 nm oscillate within a 10-dB bandwidth simultaneously. Repeat measurement of the laser spectrum shows the wavelength drift of a multiwavelength Tm-doped fiber laser is less than 0.05 nm in 40 min. (letter)

  15. Evaporation residue formation competing with the fission process in the 197Au+16O, 12C reactions and fission barriers at a specified J window

    International Nuclear Information System (INIS)

    Evaporation-residue excitation functions for 16O and 12C+197Au reactions were measured by means of the activation technique. The competition between evaporation and fission of the compound nuclei was studied by comparing the observed evaporation-residue data with the published fission excitation functions. A newly devised analysis was applied in order to deduce a fission barrier height at a specified angular momentum and determine the relevant fissioning nucleus as well. We found the fission barriers to be 8.2 MeV for the 211Fr nucleus at 16 ℎ and 8.2 MeV for the 207At nucleus at 27 ℎ. (orig.)

  16. Measurement of excitation functions and isomeric ratios of the 197Au(3He,xn)200- sup(x)Tl reactions, where x=2,3 and 4

    International Nuclear Information System (INIS)

    The excitation functions and isomer ratios of the 197Au(3He,xn)200- sup(x)Tl reactions, with x = 2, 3 and 4, were measured at bombarding energies in the range from 15 to 36 MeV. The measured values were compared to those obtained with the use of the statistical an hybrid modeles, calculated by the ALICE code. Best fit was achieved using the simple statistical model. The results were also compared to those found in literature for the (3He,xn) and (4He,xn) reactions in gold. (Author)

  17. Near-infrared Observations of Magnetars: XTE J1810-197, 1RXS J1708-4009, 1E 1841-045 and SGR 1900+14

    CERN Document Server

    Testa, V; Mignani, R P; Israel, G L; Perna, R; Chaty, S; Stella, L; Covino, S; Turolla, R; Zane, S; Curto, G Lo; Campana, S; Marconi, G; Mereghetti, S

    2007-01-01

    . We report on near-infrared (IR) observations of the three anomalous X-ray pulsars XTE J1810-197, 1RXS J1708-4009, 1E 1841-045 and the soft gamma-ray repeater SGR 1900+14, taken with the ESO-VLT, the Gemini, and the CFHT telescopes. . This work is aimed at identifying and/or confirming the IR counterparts of these magnetars, as well as at measuring their possible IR variability. . In order to perform photometry of objects as faint as Ks~20, we have used data taken with the largest telescopes, equipped with the most advanced IR detectors and in most of the cases with Adaptive Optics devices. The latter are critical to achieve the sharp spatial accuracy required to pinpoint faint objects in crowded fields. . We confirm with high confidence the identification of the IR counterpart to XTE J1810-197, and its IR variability. For 1E 1841-045 and SGR 1900+14 we propose two candidate IR counterparts based on the detection of IR variability. For 1RXS J1708-4009 we show that none of the potential counterparts within th...

  18. 4π studies of the 1.8 endash 4.8 GeV 3He+natAg, 197Au reactions. II. Multifragmentation

    International Nuclear Information System (INIS)

    Multifragmentation of natAg and 197Au nuclei induced by 1.8 endash 4.8 GeV 3He ions has been studied with the Indiana Silicon Sphere 4π detector array. Rapidity, moving source, and sphericity-coplanarity analyses are consistent with near-simultaneous emission from a source in approximate kinetic equilibrium. For the most dissipative collisions, the spectral peaks are broadened and shifted to very low energies, indicative of emission from an extended nuclear system with ρ/ρ0∼1/3. Predictions of an intranuclear cascade/expanding, emitting source model compare well with experimental multiplicity distributions and the evolution of fragment spectral shapes. copyright 1996 The American Physical Society

  19. The Clinical Relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 Network in Chemoresistant Non-small-cell Lung Cancer

    OpenAIRE

    FUJITA Yu; Yagishita, Shigehiro; Hagiwara, Keitaro; Yoshioka, Yusuke; Kosaka, Nobuyoshi; Takeshita, Fumitaka; Fujiwara, Tomohiro; Tsuta, Koji; Nokihara, Hiroshi; Tamura, Tomohide; Asamura, Hisao; Kawaishi, Makoto; Kuwano, Kazuyoshi; Ochiya, Takahiro

    2015-01-01

    Programmed cell death ligand-1 (PD-L1) has recently gained considerable attention for its role in tumor immune escape. Here, we identify a miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer (NSCLC), independent of immunoinhibitory signals. miR-197 is downregulated in platinum-resistant NSCLC specimens, resulting in the promotion of chemoresistance, tumorigenicity, and pulmonary metastasis in vitro and in vivo. Mechanistic investigations reveal that a miR-1...

  20. Roman Policies towards Antiochus III and the Greeks from Winter 197/196 B.C. to Autumn 196 B.C.

    Directory of Open Access Journals (Sweden)

    Deutschmann, Eike Hellmut

    2012-01-01

    Full Text Available In the Second Macedonian War (200-196 B.C., the res publica reduced the strength of the enemy King Philip V apparently to establish a new political order in Southern Balkans: Assumedly a pro-Roman balance of forces should prevail there, untainted by influence of another major power. A particular senatorial policy towards the Greeks probably did not exist before the fighting in Hellas came to an end in summer 197 B.C. In the same year, the Seleucid king Antiochus III brought large parts of the west coast of Asia Minor under control and set about crossing the Hellespont. Rome subsequently stylized itself as the guardian of freedom for the Greeks living in Hellas and Asia Minor. The statesmen of the res publica could have perceived Antiochus’ expansion as a threat to the mentioned new order. Therefore, the Roman Policy of Freedom was possibly applied primarily to take action against the Seleucid king. Die res publica verminderte im Zweiten Makedonischen Krieg (200-196 a.c. die Macht des gegnerischen Königs Philipp V - anscheinend um eine neue politische Ordnung im südlichen Balkanraum zu etablieren: Vermutlich sollte dort ein romfreundliches Kräftegleichgewicht vorherrschen, auf das keine andere Großmacht Einfluß hat. Eine speziell an die Griechen gerichtete Politik seitens des römischen Senats gab es wahrscheinlich nicht vor Ende der Kampfhandlungen in Hellas im Sommer 197 a.c. In dem Jahr erweiterte der seleukidische König Antiochos III. seinen Einflussbereich auf große Teile der kleinasiatischen Westküste und schickte sich an, den Hellespont zu überqueren. Rom stilisierte sich in der Folgezeit zum Freiheitsgarant der in Hellas und Kleinasien lebenden Griechen. Antiochos Expansion könnte von den Staatsmännern der res publica als Bedrohung der genannten neuen Ordnung angesehen worden sein. Demzufolge wurde die römische Freiheitspolitik möglicherweise in erster Linie angewendet, um gegen den seleukidischen König vorzugehen.

  1. Equilibration in the reaction of 175 and 252 MeV /sup 20/Ne with /sup 197/Au. [Energy, element, and angular distributions

    Energy Technology Data Exchange (ETDEWEB)

    Moulton, J.B.

    1978-06-01

    The highly inelastic nuclear reaction of /sup 197/Au with /sup 20/Ne at 175 and 252 MeV laboratory energies is studied. Energy-, elemental-, and angular- distributions for atomic numbers 5 to 30 (175 MeV) or 34 (252 MeV) are presented. The means and widths of the kinetic energy spectra for detected elements are compared with a theoretical calculation. The calculation postulates thermalization of the incident projectile kinetic energy, and includes one sha(e-vibrational degree of freedom and rigid rotation of the reaction complex. The effect of particle evaporation is considered. Good agreement of the expurimental mean energies with the theory is obtained. Poorer agreement of the kinetic energy widths with the theory may be due to a low-temperature quantal effect. The relative elemental yields are analyzed for their degree of equilibration, based on a model of diffusive nucleon exchange as described by the master equation. A similar degree of equilibration is observed for both reaction energies. The absolute elemental yields are reproduced qualitatively by employing an advanced diffusion code, coupled with calculation of the subsequent fission of heavy reaction products, including the compound nucleus. The angular distributions are analyzed with a simple model, to estimate the reaction lifetime of selected elements.

  2. Decay analysis of pre-actinide and trans-actinide nuclei formed using various projectiles on a 197Au target at ECN*=60 MeV

    Science.gov (United States)

    Grover, Neha; Kaur, Gurvinder; Sharma, Manoj K.

    2016-01-01

    The collective clusterization approach of the dynamical cluster decay model (DCM) has been applied to study the decay of odd mass nuclei 223Pa*, 215Fr*, 227Np*, and 233Am*, which are formed in heavy-ion-induced reactions. The aim of this study is to investigate the decay pattern and related behavior of these heavy mass nuclei formed in four distinct reactions involving different projectiles (with mass A =18 -36 ) induced on 197Au target nucleus. Further, in order to analyze the role of deformations, the calculations have been done by considering spherical choice of fragmentation as well as with inclusion of quadrupole (β2) deformation. For the heavy mass region, with fission being the dominant decay mode, an attempt has been made to investigate the effect of projectile mass in reference to fission decay patterns of the pre-actinide 215Fr* nucleus and the trans-actinide nuclei 227Np* 223Pa*, 223Am* and formed at common excitation energy, ECN*=60 MeV . Besides this, the shell closure effects and the role of orientation have been explored, which suggest the presence of a noncompound nucleus process such as quasifission (QF) for the odd mass nuclei under consideration. For both the compound nucleus and the noncompound nucleus processes, the results obtained using DCM are found to have nice agreement with experimental observations. The isotopic and isobaric analysis is also worked out so as to have a comprehensive idea about the dynamics involved.

  3. Ternary fission with 4He emission in 16O(144 Mev) + 232Th and 12C(108 Mev) + 197Au reactions

    International Nuclear Information System (INIS)

    Results of coincidence study of 4He emission with fission fragments in 12C (108 MeV) ions with sup(197)Au target and 16O (144 MeV) ions with sup(223)Th target reactions are presented. On the basis of Monte Carlo kinematic simulation of nuclear reactions analysis of energy and velocity spectra of α-particles has been performed. The conclusion has been performed. The conclusion has been drawn that the main source of 4He emission was the evaporation from a fissioning compound nucleus. Substantial part of α-particles was emitted from fully accelerated fission fragments. Some of 4He nuclei with mean energy of about 16 MeV emitted mainly perpendicular to the fission axis were identified as similar to long range α-particles in ternary fission of heavy nuclei with low excitation energy. Multiplicities of emission of these particles are considerably higher than those at low excitation energy. Comparison of experimental results with statistical model calculations has been made

  4. LAT, EGFR -pY197, PCNL2, CDX2, HLA-DPDQDR, bromodeoxyuridine, JAM-A, and ezrin immunoreactants in a rubbed spongiotic dermatitis

    Directory of Open Access Journals (Sweden)

    Ana Maria Abreu Velez

    2011-10-01

    Full Text Available Background: Acute and subacute spongiotic dermatitides are among the most commonly diagnosed types of dermatitis. Many patients rub their lesions, with the lesions becoming clinically thickened. The precise immunologic mechanisms within the thickening process are not well defined. Case report: An 85 year old male presented with the sudden clinical appearance of erythematous patches and small blisters on the back of his legs, with pruritis. Methods: Skin biopsies, one from a rubbed lesion and one from a non-rubbed lesion were submitted for hematoxylin and eosin (H&E, immunohistochemistry (IHC, and for direct immunofluorescence (DIF analysis. Results: The H&E staining demonstrated classic features of a spongiotic dermatitis, but in the rubbed areas psoriasiform hyperplasia was also seen. The psoriasiform areas demonstrated positive, focal IHC staining with bromodeoxyuridine, LAT, EGFR-pY197, PCNL2, CDX2, and HLA-DPDQDR antibodies. DIF staining revealed positive staining of JAM-A and ezrin in the non-rubbed specimens in both the spongiotic epidermis and in the adjacent vessels; normal expression of these markers was appreciated in the rubbed biopsy. Conclusions: The immune response seems to be complex when a spongiotic dermatitis is converted from a non-rubbed to a rubbed lesion with histologic features of psoriasiform hyperplasia.

  5. Search for mass-symmetric ternary fission in the reactions {sup 14}N(53 A MeV)+{sup 197}Au and {sup 232}Th

    Energy Technology Data Exchange (ETDEWEB)

    Herbach, C.-M. E-mail: herbach@hmi.de; Hilscher, D.; Tishchenko, V.G.; Gippner, P.; Kamanin, D.V.; Oertzen, W. von; Ortlepp, H.-G.; Penionzhkevich, Yu.E.; Pyatkov, Yu.V.; Renz, G.; Schilling, K.D.; Strekalovsky, O.V.; Wagner, W.; Zhuchko, V.E

    2002-12-30

    Ternary fission of heavy hot composite systems with excitation energies of 1.5-2.5 MeV/amu has been studied in the reactions of {sup 14}N(53 A MeV) with {sup 197}Au and {sup 232}Th. The ternary yields have been explored as a function of the charge Z{sub L} of the lightest fragment: while Z{sub L} increases from 6 to 25, the cross sections decrease from 5 to 0.08 mb for N+Au and from 15 to 0.8 mb for N+Th. The velocity vector v{yields}{sub L} of the lightest fragment has been investigated in the rest frame of the other two heavier fragments. Two different components are observed: (i) an isotropic one with values of v{sub L} corresponding to the Coulomb repulsion from the combined heavier fragments before separation and, (ii) an anisotropic contribution with the lightest fragment emitted with lower v{sub L} perpendicular to the scission axis of the two heavier fragments. The latter component is distinguished from the isotropic one by an enhanced fraction of mass-symmetric ternary events and by up to 50 MeV lower total kinetic fragment energies. These features are indicative of a collinear stretched scission configuration, where the lightest fragment is positioned between the two heavier ones.

  6. Study of the fission process of 200Pb and 197Tl produced in fusion reactions with the modified statistical model and multidimensional dynamical model

    Science.gov (United States)

    Eslamizadeh, H.

    2015-09-01

    The fission probability, pre-scission neutron, proton and alpha multiplicities, anisotropy of fission fragment angular distribution and the fission time have been calculated for the compound nuclei 200Pb and 197Tl based on the modified statistical model and four-dimensional dynamical model. In dynamical calculations, dissipation was generated through the chaos weighted wall and window friction formula. The projection of the total spin of the compound nucleus to the symmetry axis, K, was considered as the fourth-dimension in Langevin dynamical calculations. In our dynamical calculations, we have used a constant dissipation coefficient of K, {γ }K=0.077{({{MeV}} {{zs}})}-{1/2}, and a non-constant dissipation coefficient to reproduce the above-mentioned experimental data. Comparison of the theoretical results of the fission probability and pre-scission particle multiplicities with the experimental data showed that the difference between the results of both dynamical models is small whereas, for the anisotropy of fission fragment angular distribution, it is slightly large. Furthermore, comparison of the results of the modified statistical model with the above-mentioned experimental data showed that with choosing appropriate values of the temperature coefficient of the effective potential, λ , and the scaling factor of the fission-barrier height, {r}s, the experimental data were satisfactorily reproduced.

  7. Study of the A(e,e'$\\pi^+$) Reaction on $^1$H, $^2$H, $^{12}$C, $^{27}$Al, $^{63}$Cu and $^{197}$Au

    Energy Technology Data Exchange (ETDEWEB)

    Qian, X; Clasie, B; Arrington, J; Asaturyan, R; Benmokhtar, F; Boeglin, W; Bosted, P; Bruell, A; Christy, M E; Chudakov, E; Dalton, M M; Daniel, A; Day, D; Dutta, D; El Fassi, L; Ent, R; Fenker, H C; Ferrer, J; Fomin, N; Gao, H; Garrow, K; Gaskell, D; Gray, C; Huber, G M; Jones, M K; Kalantarians, N; Keppel, C E; Kramer, K; Li, Y; Liang, Y; Lung, A F; Malace, S; Markowitz, P; Matsumura, A; Meekins, D G; Mertens, T; Miyoshi, T; Mkrtchyan, H; Monson, R; Navasardyan, T; Niculescu, G; Niculescu, I; Okayasu, Y; Opper, A K; Perdrisat, C; Punjabi, V; Rauf, A W; Rodriquez, V M; Rohe, D; Seely, J; Segbefia, E; Smith, G R; Sumihama, M; Tadevosyan, V; Tang, L; Villano, A; Vulcan, W F; Wesselmann, F R; Wood, S A; Yuan, L; Zheng, X

    2010-05-01

    Cross sections for the p($e,e'\\pi^{+}$)n process on $^1$H, $^2$H, $^{12}$C, $^{27}$Al, $^{63}$Cu and $^{197}$Au targets were measured at the Thomas Jefferson National Accelerator Facility (Jefferson Lab) in order to extract the nuclear transparencies. Data were taken for four-momentum transfers ranging from $Q^2$=1.1 to 4.8 GeV$^2$ for a fixed center of mass energy of $W$=2.14 GeV. The ratio of $\\sigma_L$ and $\\sigma_T$ was extracted from the measured cross sections for $^1$H, $^2$H, $^{12}$C and $^{63}$Cu targets at $Q^2$ = 2.15 and 4.0 GeV$^2$ allowing for additional studies of the reaction mechanism. The experimental setup and the analysis of the data are described in detail including systematic studies needed to obtain the results. The results for the nuclear transparency and the differential cross sections as a function of the pion momentum at the different values of $Q^2$ are presented. Global features of the data are discussed and the data are compared with the results of model calculations for the p($e,e'\\pi^{+}$)n reaction from nuclear targets.

  8. Calibration factors for determination of relativistic particle induced fission rates in natU, 235U, 232Th, natPb and 197Au foils

    International Nuclear Information System (INIS)

    Calibration factors w, for determination of fission rate in metallic foils of natU, 235U, 232Th, natPb and 197Au were determined for foils in contact with synthetic mica track detectors. Proton-induced fission at proton energies of 0.7 GeV and 1.5 GeV were used. Using our experimental results as well as those of the other authors, w for different foil-mica systems were determined. Two methods were used to calculate w, relative to the calibration factor for uranium-mica system, which has been obtained in a standard neutron field of energy 14.7 MeV. One of these methods requires the knowledge of the mean range of the fission fragments in the foils of interest and other method needs information on the values of the fission cross-sections at the required energies as well as the density of the tracks recorded in the track detectors in contact with the foil surfaces. The obtained w-values were compared with Monte Carlo calculations and good agreements were found. It is shown that a calibration factor obtained at low energy neutron induced fissions in uranium isotopes deviates only by less than 10% from those obtained at relativistic proton induced fissions.

  9. Determining conductivity and mobility values of individual components in multiphase composite Cu{sub 1.97}Ag{sub 0.03}Se

    Energy Technology Data Exchange (ETDEWEB)

    Day, Tristan W.; Brown, David R.; Snyder, G. Jeffrey, E-mail: jsnyder@caltech.edu [Department of Materials Science, California Institute of Technology, MC 309-81, Pasadena, California 91106 (United States); Zeier, Wolfgang G. [Department of Materials Science, California Institute of Technology, MC 309-81, Pasadena, California 91106 (United States); Department of Chemistry, University of Southern California, Seeley G. Mudd Bldg., 3620 McClintock Ave., Los Angeles, California 90089-1062 (United States); Melot, Brent C. [Department of Chemistry, University of Southern California, Seeley G. Mudd Bldg., 3620 McClintock Ave., Los Angeles, California 90089-1062 (United States)

    2014-10-27

    The intense interest in phase segregation in thermoelectrics as a means to reduce the lattice thermal conductivity and to modify the electronic properties from nanoscale size effects has not been met with a method for separately measuring the properties of each phase assuming a classical mixture. Here, we apply effective medium theory for measurements of the in-line and Hall resistivity of a multiphase composite, in this case Cu{sub 1.97}Ag{sub 0.03}Se. The behavior of these properties with magnetic field as analyzed by effective medium theory allows us to separate the conductivity and charge carrier mobility of each phase. This powerful technique can be used to determine the matrix properties in the presence of an unwanted impurity phase, to control each phase in an engineered composite, and to determine the maximum carrier concentration change by a given dopant, making it the first step toward a full optimization of a multiphase thermoelectric material and distinguishing nanoscale effects from those of a classical mixture.

  10. Determination of bacterial endotoxin content of diphtheria toxin mutant CRM 197 by kinetic chromogenic assay%动态显色法检测白喉毒素突变体CRM197的细菌内毒素含量

    Institute of Scientific and Technical Information of China (English)

    邓杰; 张珂; 袁涛; 李春阳

    2013-01-01

    目的 建立检测白喉毒素突变体CRM197细菌内毒素(bacterial endotoxin)含量的动态显色法(kinetic chromogenic assay,KCA).方法 按照《中国药典》三部(2010版)要求,用细菌内毒素检查用水(bacterial endotoxin,BET)稀释细菌内毒素工作标准品制备细菌内毒素标准曲线系列溶液,各浓度均设3个平行孔,分别与动态显色鲎试剂(kinetic chromogenic analysis tachypleus amebocyte lysate,KCA TAL)反应,绘制标准曲线,验证标准曲线的可靠性,确定最佳线性范围、测定范围及最低检测限(limit of quantitation,LOQ),验证方法的精密性和准确性,并进行初步应用.结果 标准曲线的回归方程为:y=-0.263x+2.741,R2=0.997,相关系数的绝对值|r|≥0.980,阴性对照的反应时间大于标准曲线最低点的反应时间,各复孔的变异系数(CV)<10%;内毒素浓度在0.02~2.50EU/ml时,线性关系良好,LOQ为0.02 EU/ml;3个浓度(2.50、0.50、0.02 EU/ml)标准内毒素检测结果的CV均<5%,加入高、中、低3个浓度(2.50、0.50、0.02 EU/ml)标准内毒素的3批供试品检测结果的CV均<10%,回收率在95% ~ 143%之间;采用建立的方法检测10批次CRM197样品的细菌内毒素含量,回收率在77%~118%之间,其中8批样品的内毒素含量合格.结论 动态显色法检测CRM197中内毒素的含量精密性和准确性良好,能快速、定量检测样品中的内毒素含量,抗干扰能力强,可用于CRM197研制过程中的质量控制.

  11. Analysis of chemical composition of urinary calculi%南疆地区197例患者泌尿系结石成份分析

    Institute of Scientific and Technical Information of China (English)

    黄睿; 孟晓辉

    2012-01-01

    Objective To analyze the composition of urinary stone and investigate its prevention method. Methods 197 cases with urinary stones related to melamine milk were collected. The qualitative determination was performed by infrared spectroscopy automatic analyzer. Results 8 components in urinary stone were detected. 98 cases (51. 8%) were pure type, while 91 cases (48. 1%) were the mixed type. 38% of the calculi were calcium-containing stones. 34. 8% of the stones were non-calcium- containing. The rest were mixed. The percentage of various stone compositions were as follows: urinary ammonium calculi was 44. 9% (48 cases) , calcium oxalate monohydrate (COM) + urinary ammonium calculi was 28. 5% (28 cases), calcium lactate was 26. 8% (24cases). The clinical features of three kinds of urinary stones were Uygur nationality cases accounted for 67% , 71% male and 52. 8% was infants under 3 years old. The proportion of patients with kidney stones was 61. 4%. The urinary stones ammonium was the main ingredient, while a certain percentage of patients with calcium oxalate stones. Conclusion Combination of case history, inferred that incidence of kidney stones in Uighur nationality is higher than that of Han nationality significantly. It is inferred that urinary ammonium stones could be easily induced by melamine milk powder.%目的 探讨南疆地区泌尿系结石患者的结石成份及防治方法.方法 搜集新疆南部地区与三聚氰胺奶粉相关尿路结石病例197例.手术取石,采用红外光谱自动分析仪定性检测.结果 除外8例资料不全,纳入统计189例,共检测出8种成份,其中单纯成份结石51.85%(98例),混合成份结石48.15%(91例).按结石主要成份分为含钙结石72例(38%),非钙结石66例(34.8%),混合型结石51例(28%).各种成份的结石病例的构成比从高到低依次为尿酸铵结石44例(44.9%),一水草酸钙和尿酸铵28例(28.5%),一水草酸钙24例(26.3%).三种结石的临床特点是67

  12. Dual binding mode of antithyroid drug methimazole to mammalian heme peroxidases - structural determination of the lactoperoxidase-methimazole complex at 1.97 Å resolution.

    Science.gov (United States)

    Singh, Rashmi Prabha; Singh, Avinash; Sirohi, Harsh Vardhan; Singh, Amit Kumar; Kaur, Punit; Sharma, Sujata; Singh, Tej P

    2016-07-01

    Lactoperoxidase (LPO, EC 1.11.1.7) is a member of the mammalian heme peroxidase family which also includes thyroid peroxidase (TPO). These two enzymes have a sequence homology of 76%. The structure of LPO is known but not that of TPO. In order to determine the mode of binding of antithyroid drugs to thyroid peroxidase, we have determined the crystal structure of LPO complexed with an antithyroid drug, methimazole (MMZ) at 1.97 Å resolution. LPO was isolated from caprine colostrum, purified to homogeneity and crystallized with 20% poly(ethylene glycol)-3350. Crystals of LPO were soaked in a reservoir solution containing MMZ. The structure determination showed the presence of two crystallographically independent molecules in the asymmetric unit. Both molecules contained one molecule of MMZ, but with different orientations. MMZ was held tightly between the heme moiety on one side and the hydrophobic parts of the side chains of Arg255, Glu258, and Leu262 on the opposite side. The back of the cleft contained the side chains of Gln105 and His109 which also interacted with MMZ. In both orientations, MMZ had identical buried areas and formed a similar number of interactions. It appears that the molecules of MMZ can enter the substrate-binding channel of LPO in two opposite orientations. But once they reach the distal heme pocket, their orientations are frozen due to equally tight packing of MMZ in both orientations. This is a novel example of an inhibitor binding to an enzyme with two orientations at the same site with nearly equal occupancies. PMID:27398304

  13. Synthesis and characterization of multidoped lithium manganese oxide spinel LiCo0.02La0.01Mn1.97O3.98Cl0.02

    Institute of Scientific and Technical Information of China (English)

    ZHANG Na; TANG Zhi-yuan; HUANG Qing-hua; LU Xing-he

    2006-01-01

    Multidoped spinel LiCo0.02La0.01Mn1.97O3.98Cl0.02 was synthesized by solid-state method. The structure and electrochemical performance were characterized by XRD, ESEM, particle size distribution analysis, specific surface area testing, galvanostatic cycling and electrochemical impedance spectroscopy. The XRD analysis shows that the sample exhibits pure spinel phase. The substitution of Co, La for Mn and Cl for O in the LiMn2O4 stabilizes the structural integrity of the spinel host, which in turn increases the electrochemical cycleability. The electrochemical experiments confirm that the capacity of the LiCo0.02La0.01Mn1.97O3.98Cl0.02electrode maintains 90.6% of the initial capacity at 180th cycle.

  14. Study on Safety and Immunogenicity of Haemophilus Influenzae Type b Conjugate Vaccine (Polyribosylribitol Phosphate-Cross Reacting Material 197) among the Children Aged 13-59 Months%b型流行性感冒嗜血杆菌结合疫苗(磷酸多核糖基核糖醇-白喉毒素突变体197)在13~59月龄儿童中的安全性和免疫原性研究

    Institute of Scientific and Technical Information of China (English)

    陈玉国; 李军; 刘金凤; 孟华伟; 谢艳华; 李秀华; 朱永贵; 马景臣; 赵玉良

    2013-01-01

    Objective To evaluate the safety and immunogenicity of a Haemophilus influenzae type b (Hib) conjugated vaccine (polyribosylribitol phosphate-cross reacting material 197,PRP-CRM197)among the toddlers and young children from13 months to 59 months.Methods 728 children from 13 to 59 months which were divided into two groups randomly.The trial group (N=365)were administered one dose of the PRP-CRM197 by intramuscular injection,the control group (N=363)were administered one dose of the PRP-T (tetanus toxoid).Both the local and systemic adverse reactions were observed during the first 7 days after vaccination.The Adverse Events Following Immunization (AEFIs) and any medicine used were reported within 30 days after vaccination.Blood samples were collected before vaccination and 30 days after the vaccination.Levels of antibody to PRP (Anti-PRP) were measured by enzymelinked immunosorbant assay (EIISA).Results 99% and 100% of subjects receiving PRP-CRM197 and PRP-T achieved Short term (≥ 0.15μg/ml) and long-term (≥ 1.0μg/ml) seroprotective Anti-PRP levels respectively,were Both formulations had similar safety profiles.Conclusion One dose of PRP-CRM197 has good tolerance and the immunogenicity which is similar to one dose of PRP-T,which provide seroprotective antibody titres against Hib infection to 99% subjects.PRP-CRM197 is suitable for routine immunization against Haemophilus Influenzae Type b disease for children among the age of 13-59 months.Clinical Trial Registration State Food and Drug Administration Approval Number:2008 L03160.%目的 评价b型流行性感冒嗜血杆菌结合疫苗(Haemophilus Influenzae Type b Conjugate Vaccine,Hib)[磷酸多核糖基核糖醇-白喉毒素突变体197(Polyribosylribitol Phosphate-Cross Reacting Material 197,PRP-CRM197)]在13~59月龄儿童中使用的安全性和免疫原性.方法 选择728名13~59月龄儿童,按1∶1的比例随机分配到试验组(365人)和对照组(363人),分

  15. Validation of absolute axial neutron flux distribution calculations with MCNP with 197Au(n,γ)198Au reaction rate distribution measurements at the JSI TRIGA Mark II reactor.

    Science.gov (United States)

    Radulović, Vladimir; Štancar, Žiga; Snoj, Luka; Trkov, Andrej

    2014-02-01

    The calculation of axial neutron flux distributions with the MCNP code at the JSI TRIGA Mark II reactor has been validated with experimental measurements of the (197)Au(n,γ)(198)Au reaction rate. The calculated absolute reaction rate values, scaled according to the reactor power and corrected for the flux redistribution effect, are in good agreement with the experimental results. The effect of different cross-section libraries on the calculations has been investigated and shown to be minor. PMID:24316530

  16. Measurement of the (n,2n) cross sections for 89Y, 93Nb, 103Rh, 107Ag, 169Tm, 175Lu and 197Au at 14.1 and 14.8 MeV incident neutron energies

    International Nuclear Information System (INIS)

    The (n,2n) cross sections for 89Y, 93Nb, 103Rh, 107Ag, 169Tm, 175Lu and 197Au have been measured at 14.1 and 14.8 MeV incident neutron energies. The samples were irradiated at the 14 MeV neutron generator of C.E. VALDUC. 27Al(n,α)24Na cross section was used for standard. The cross sections were obtained with an accuracy of about 5%

  17. Results from two years of Matricaria inodora L. and Matricaria chamomilla L. monitoring (2012 + 2013 – greenhouse efficacy trials with Tribenuron and Florasulam and ALS target site resistance test at Pro 197 and Thr 574

    Directory of Open Access Journals (Sweden)

    Tiede, Anke

    2014-02-01

    Full Text Available The first ALS resistant Matricaria chamomilla (MATCH biotype was found in 2006 in Schleswig Holstein in Witzwort (SCHLEICH-SAIDFAR et al., 2011. Since 2006 ALS resistant Matricaria chamomilla and Matricaria inodora (MATIN were found at other locations near the North Sea coastline in Schleswig-Holstein and Lower Saxony (ULBER et al., 2012. As there were more and more cases of reduced efficacy of sulfonylureas on mayweed, Dow AgroSciences decided in 2012 and 2013 to test MATCH and MATIN samples in Germany. In 2012 seed samples collected by Dow AgroSciences were planted in greenhouse environment and treated with tribenuron or florasulam. As a second step plants were checked for mutations of the ALS gene at positions Pro 197 and Thr 574 via Pyrosequencing. In Europe there is no known case of metabolic ALS-resistance (ULBER et al., 2012. It was found that mayweed plants showed a mutation at position Pro 197 only. In 2013 leaf samples were taken only and investigated for mutations of ALS position Pro 197 and Thr 574.

  18. Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes (The FinnDiane Study

    Directory of Open Access Journals (Sweden)

    Wadén Johan

    2009-10-01

    Full Text Available Background Cardiovascular disease is the main cause of premature death in patients with type 1 diabetes. Patients with diabetic kidney disease have an increased risk of heart attack or stroke. Accurate knowledge of the complex inter-dependencies between the risk factors is critical for pinpointing the best targets for research and treatment. Therefore, the aim of this study was to describe the association patterns between clinical and biochemical features of diabetic complications. Methods Medical records and serum and urine samples of 4,197 patients with type 1 diabetes were collected from health care centers in Finland. At baseline, the mean diabetes duration was 22 years, 52% were male, 23% had kidney disease (urine albumin excretion over 300 mg/24 h or end-stage renal disease and 8% had a history of macrovascular events. All-cause mortality was evaluated after an average of 6.5 years of follow-up (25,714 patient years. The dataset comprised 28 clinical and 25 biochemical variables that were regarded as the nodes of a network to assess their mutual relationships. Results The networks contained cliques that were densely inter-connected (r > 0.6, including cliques for high-density lipoprotein (HDL markers, for triglycerides and cholesterol, for urinary excretion and for indices of body mass. The links between the cliques showed biologically relevant interactions: an inverse relationship between HDL cholesterol and the triglyceride clique (r P -16, a connection between triglycerides and body mass via C-reactive protein (r > 0.3, P -16 and intermediate-density cholesterol as the connector between lipoprotein metabolism and albuminuria (r > 0.3, P -16. Aging and macrovascular disease were linked to death via working ability and retinopathy. Diabetic kidney disease, serum creatinine and potassium, retinopathy and blood pressure were inter-connected. Blood pressure correlations indicated accelerated vascular aging in individuals with kidney disease

  19. The IL-17A G-197A and IL-17F 7488T/C polymorphisms are associated with increased risk of cancer in Asians: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Wang H

    2015-09-01

    Full Text Available Huifen Wang,1,* Yanli Zhang,1,* Zhaolan Liu,2 Yin Zhang,3 Hongchuan Zhao,1 Shiyu Du1 1Department of Gastroenterology, China-Japan Friendship Hospital, 2Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, 3Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China *These authors contributed equally to this work Background: Interleukin-17 (IL-17 is a family of emerged pro-inflammatory cytokines. The IL-17A and IL-17F are two important members of IL-17 family. Previous studies have shown that the functional IL-17A G-197A and IL-17F 7488T/C polymorphisms may contribute to susceptibility to cancer but the results were inconclusive. This meta-analysis was performed to determine the exact association between IL-17 polymorphisms and cancer risk.Methods: Online databases were searched to identify eligible case–control studies. Pooled odds ratios (ORs and confidence intervals (CIs were calculated by fixed-effect models or random-effect models. Publication bias was detected by Egger’s test and Begg’s test.Results: Nine eligible case–control studies of IL-17A G-197A and seven studies of IL-17F 7488T/C, including 3,181 cases and 4,005 controls, were identified. Pooled analysis suggested the variant IL-17A-197A allele was associated with increased risk cancer (GA/AA vs GG, OR =1.27, 95% CI: 1.15, 1.41, Pheterogeneity =0.374; and A vs G, OR =1.30, 95% CI: 1.17, 1.45, Pheterogeneity =0.021. For IL-17F 7488T/C, the homozygote 7488CC genotype significantly increased risk of cancer (CC vs TC/TT, OR =1.36, 95% CI: 0.97, 1.91, Pheterogeneity =0.875; and CC vs TT, OR =1.39, 95% CI: 1.03, 1.88, Pheterogeneity =0.979, especially for gastric cancer.Conclusion: The variant IL-17A-197A allele and IL-17F 7488CC genotype were associated with increased risk of cancer, especially for gastric cancer. Keywords: interleukin-17, gene polymorphism, gastric cancer, risk

  20. 4{pi} studies of the 1.8{endash}4.8 GeV {sup 3}He+{sup nat}Ag, {sup 197}Au reactions. I. Energy deposition

    Energy Technology Data Exchange (ETDEWEB)

    Morley, K.B.; Kwiatkowski, K.; Bracken, D.S.; Renshaw Foxford, E.; Viola, V.E.; Woo, L.W.; Yoder, N.R. [Departments of Chemistry and Physics and Indiana University Cyclotron Facility, Indiana University, Bloomington, Indiana 47405 (United States); Legrain, R.; Pollacco, E.C.; Volant, C. [Commissariat a l`Energie Atomique, DAPNIA Service de Physique Nucleaire, C.E. Saclay, 91191 Gir-sur-Yvette Cedex (France); Korteling, R.G. [Department of Chemistry, Simon Fraser University, Burnaby, British Columbia (Canada); Breuer, H. [University of Maryland, College Park, Maryland 20742 (United States); Brzychczyk, J. [Institute of Physics, Jagiellonian University, 30-059 Krakow (Poland)

    1996-08-01

    The Indiana Silicon Sphere 4{pi} detector has been used to measure light-charged particles and intermediate-mass fragments (IMFs) emitted in the 18{endash}4.8 GeV {sup 3}He+{sup nat}Ag, {sup 197}Au reactions. Ejectile multiplicity and total event kinetic energy distributions scale systematically with projectile energy and target mass, except for the {sup nat}Ag target at 3.6 and 4.8 GeV. For this system, a saturation in deposition energy is indicated by the data, suggesting the upper projectile energy for stopping has been reached. Maximum deposition energies of {approximately}950 MeV for the {sup nat}Ag target and {approximately}1600 MeV for the {sup 197}Au target are inferred from the data. The results also demonstrate the importance of accounting for fast cascade processes in defining the excitation energy of the targetlike residue. Correlations between various observables and the average IMF multiplicity indicate that the total thermal energy and total observed charge provide useful gauges of the excitation energy of the fragmenting system. Comparison of the experimental distributions with intranuclear cascade predictions shows qualitative agreement. {copyright} {ital 1996 The American Physical Society.}

  1. 外固定架加克氏针固定治疗桡骨远端粉碎性骨折197例临床分析

    Institute of Scientific and Technical Information of China (English)

    崔裕伟

    2014-01-01

    目的:探讨外固定架加克氏针固定治疗桡骨远端粉碎性骨折的临床疗效。方法:回顾性分析我院2000年3月~2011年6月施行外固定架加克氏针固定治疗桡骨远端粉碎性骨折197例患者的临床资料。结果:本组197例均获得随访3个月~2年,平均6个月。桡骨骨折全部愈合,平均愈合时间6.1周。腕关节功能按Dient评定标准评定,优168例,良22例,可7例。结论:外固定架加克氏针固定治疗桡骨远端粉碎性骨折方法简单、适用范围广,不需二次手术,疗效显著,可临床推广。

  2. Thermal neutron calibration of a tritium extraction facility using the 6Li(n,t)4He/197Au(n,γ)198Au cross section ratio for standardization

    International Nuclear Information System (INIS)

    Absolute tritium activities in a neutron-activated metallic lithium samples have been measured by liquid scintillation methods to provide data needed for the determination of capture-to-fission ratios in fast breeder reactor spectra and for recent measurements of the 7Li(n,n't)4He cross section. The tritium extraction facility used for all these experiments has now been calibrated by measuring the 6Li(n,t)4He/197Au/n,γ)198Au activity ratio for thermal neutrons and comparing the result with the well-known cross sections. The calculated-to-measured activity ratio was found to be 1.033 +- 0.018. 2 figures, 20 tables

  3. 4{pi} studies of the 1.8{endash}4.8 GeV {sup 3}He+{sup nat}Ag, {sup 197}Au reactions. II. Multifragmentation

    Energy Technology Data Exchange (ETDEWEB)

    Renshaw Foxford, E.; Kwiatkowski, K.; Bracken, D.S.; Morley, K.B.; Viola, V.E.; Yoder, N.R. [Departments of Chemistry and Physics and Indiana University Cyclotron Facility, Indiana University, Bloomington, Indiana 47405 (United States); Volant, C.; Pollacco, E.C.; Legrain, R. [Commissariat a l`Energie Atomique, DAPNIA Service de Physique Nucleaire, C. E. Saclay, 91191 Gif-sur-Yvette, Cedex (France); Korteling, R.G. [Department of Chemistry, Simon Fraser University, Burnaby, British Columbia (Canada); Friedman, W.A. [Department of Physics, University of Wisconsin, Madison, Wisconsin 53706 (United States); Brzychczyk, J. [Institute of Physics, Jagiellonian University, 30-059 Krakow (Poland); Breuer, H. [Department of Physics, University of Maryland, College Park, Maryland 20742 (United States)

    1996-08-01

    Multifragmentation of {sup nat}Ag and {sup 197}Au nuclei induced by 1.8{endash}4.8 GeV {sup 3}He ions has been studied with the Indiana Silicon Sphere 4{pi} detector array. Rapidity, moving source, and sphericity-coplanarity analyses are consistent with near-simultaneous emission from a source in approximate kinetic equilibrium. For the most dissipative collisions, the spectral peaks are broadened and shifted to very low energies, indicative of emission from an extended nuclear system with {rho}/{rho}{sub 0}{approximately}1/3. Predictions of an intranuclear cascade/expanding, emitting source model compare well with experimental multiplicity distributions and the evolution of fragment spectral shapes. {copyright} {ital 1996 The American Physical Society.}

  4. Measurement of Fragment Production Cross Sections in the $^{12}$C+$^{12}$C and $^{12}$C+$^{197}$Au Reactions at 62 $A$ MeV for Hadrontherapy and Space Radiation Protection

    CERN Document Server

    Tropea, S; Agodi, C; Blancato, A A; Bondì, M; Cappuzzello, F; Carbone, D; Cavallaro, M; Cirrone, G A P; Cuttone, G; Giacoppo, F; Nicolosi, D; Pandola, L; Raciti, G; Rapisarda, E; Romano, F; Sardina, D; Scuderi, V; Sfienti, C

    2014-01-01

    Over the last twenty years, there has been a renewed interest in nuclear fragmentation studies for both hadrontherapy applications and space radiation protection. In both fields, fragmentation cross sections are needed to predict the effects of the ions nuclear interactions within the patient’s and the astronaut’s body. Indeed, the Monte Carlo codes used in planning tumor treatments and space missions must be tuned and validated by experimental data. However, only a limited set of fragmentation cross sections are available in literature, especially at Fermi energies. Therefore, we have studied the production of secondary fragments in the 12 C+ 12 C and 12 C+ 197 Au reactions at 62 A MeV. In this work, the measured 4 He cross sections angular distributions at four selected angles are presented and compared.

  5. Preresidue'' light charged particles from [sup 28]Si+[sup 165]Ho, [sup 16]O+[sup 197]Au, and [sup 16]O+[sup 208]Pb fusion

    Energy Technology Data Exchange (ETDEWEB)

    Fineman, B.J.; Brinkmann, K.; Caraley, A.L.; Gan, N.; McGrath, R.L.; Velkovska, J. (Physics Department, State University of New York at Stony Brook, Stony Brook, New York 11794 (United States))

    1994-10-01

    Proton and [alpha]-particle spectral shapes and multiplicities have been measured in coincidence with evaporation residues from 145 to 220 MeV [sup 28]Si+[sup 165]Ho and 115 and 140 MeV [sup 16]O+[sup 197]Au,[sup 208]Pb fusion reactions. Evaporation residues were separated using an electrostatic deflector and detected with large area surface barrier detectors. Light charged particles were detected at forward and backward angles with 14 single NaI detectors. In the context of the statistical model, the charged particle spectra provide information about the shapes and level densities of the emitting systems. Deformed emitters are inferred, and to a varying degree, an energy-dependent level density parameter is compatible with the data in each of the three cases. Implications for current fusion and fission dynamics studies are discussed.

  6. Effects of in-medium cross-sections and optical potential on thermal-source formation in p+197Au reactions at 6.2-14.6 GeV/c

    CERN Document Server

    Turbide, S; Danielewicz, P; Viola, V E; Roy, R; Kwiatkowski, K; Hsi, W C; Wang, G; Lefort, T; Bracken, D S; Breuer, H; Cornell, E; Gimeno-Nogues, F; Ginger, D S; Gushue, S; Huang, R; Korteling, R; Lynch, W G; Morley, K B; Ramakrishnan, E; Remsberg, L P; Rowland, D; Tsang, M B; Xi, H; Yennello, S J

    2004-01-01

    Effects of in-medium cross-sections and of optical potential on pre-equilibrium emission and on formation of a thermal source are investigated by comparing the results of transport simulations with experimental results from the p+{197}Au reaction at 6.2-14.6 GeV/c. The employed transport model includes light composite-particle production and allows for inclusion of in-medium particle-particle cross-section reduction and of momentum dependence in the particle optical-potentials. Compared to the past, the model incorporates improved parameterizations of elementary high-energy processes. The simulations indicate that the majority of energy deposition occurs during the first ~25 fm/c of a reaction. This is followed by a pre-equilibrium emission and readjustment of system density and momentum distribution toward an equilibrated system. Good agreement with data, on the d/p and t/p yield ratios and on the residue mass and charge numbers, is obtained at the time of ~ 65 fm/c from the start of a reaction, provided red...

  7. Estimation of double differential angle-dependent neutron production cross sections from tritons on 197Au at energies from 5.97 to 19.14 MeV

    CERN Document Server

    Drosg, Manfred

    2016-01-01

    Estimated cross sections for neutron production from triton bombardment of gold are deduced from measurements of triton interactions with gas targets that used gold as a triton beam stop material. Differential cross sections for production of neutrons from 5.97-, 7.47-, 10.45-, 16.41- and 19.14-MeV tritons on 197Au were evaluated. Corrections for the neutron interaction in gold, in the target structure and in the air of the flight path were obtained by means of a Monte Carlo technique. Uncorrelated scale uncertainties range from 24 to 41% whereas those of double differential cross sections range from 0.2 to 5%. Based on these cross section data, calculation of neutron yield at 0o from fully stopped tritons at 20.22 MeV agree with an independent measurement. Least-squares fits with a gamma distribution model indicate an anisotropy in the high energy portion of the neutron spectra. Legendre polynomial fits of differential cross sections are reported. All neutron cross section data are made available through the...

  8. {open_quotes}Pre-residue{close_quotes} light charged particles from {sup 28}Si+{sup 165}Ho and {sup 16}O+{sup 197}Au, {sup 208}Pb fusion

    Energy Technology Data Exchange (ETDEWEB)

    Fineman, B.J.; Brinkmann, K.T.; Caraley, A.L.; Gan, N.; McGrath, R.L.; Velkovska, J.

    1993-10-01

    Proton and alpha particle spectral shapes and multiplicities have been measured in coincidence with evaporation residues from {sup 28}Si+{sup 165}Ho and {sup 16}O + {sup 197}Au, {sup 208}Pb fusion reactions. Our experiments used 145 to 220 MeV {sup 28}Si and 115 and 140 MeV {sup 16}O beams produced with the Stony Brook LINAC. ER`s were separated using an electrostatic deflector and detected with large area surface barrier detectors. Light charged particles were detected at forward and backward angles with fourteen single NaI detectors. In the context of the statistical model, charged particle spectra yield information about emission barriers and compound nucleus equilibrium level densities. These are significant ingredients in calculations determining fission timescales from other observables such as pre-scission neutron multiplicities or fusion-evaporation excitation functions. Results will also be compared to analyses of pre-scission charged particles from similar systems which required barrier reductions to describe measured spectra.

  9. 46 CFR 197.410 - Dive procedures.

    Science.gov (United States)

    2010-10-01

    ... SCUBA divers shall maintain their own profiles; (5) A two-way voice communication system is used between...); and (ii) The bell (when provided) and the dive location; (6) A two-way communication system is...) The physical condition of the diver is checked by— (A) Visual observation; and (B) Questioning...

  10. Burrowing Owl - Palo Verde Valley [ds197

    Data.gov (United States)

    California Department of Resources — These burrowing owl observations were collected during the spring and early summer of 1976 in the Palo Verde Valley, eastern Riverside County, California. This is...

  11. 46 CFR 197.204 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... diver or bell, or between a diver and a bell, that supplies the diver or bell with a life-line, breathing gas, communications, power, and heat as appropriate to the diving mode or conditions. Vessel means... Institute “Code for Pressure Piping, Power Piping.” ASME Code means the American Society of...

  12. The expression profile of Dopamine D2 receptor, MGMT and VEGF in different histological subtypes of pituitary adenomas: a study of 197 cases and indications for the medical therapy

    Science.gov (United States)

    2014-01-01

    Background To study the expression of D2R, MGMT and VEGF for clinical significance in pituitary adenomas, and to predict the potential curative medical therapy of dopamine agonists, temozolomide and bevacizumab on pituitary adenomas. Methods Immunohistochemistry and western blot were performed to detect the expression of expression of D2R, MGMT and VEGF in pituitary adenoma tissue samples. The ratio of high expression of D2R, MGMT or VEGF in different subtypes of PA was compared by the use of chi-squared tests. The relationships between D2R, MGMT and VEGF expression were assessed by the Spearman rank correlation test. The association between their expression and clinical parameters was analyzed using a chi-squared test, or Fisher's exact probability test when appropriate. Results The data showed that in 197 different histological subtypes of pituitary adenomas (PAs), 64.9% of them were D2R high expression, 86.3% were MGMT low expression and 58.9% were VEGF high expression. D2R high expression existed more frequently in PRL- and GH- secreting PAs. MGMT low expression existed in all PA subtypes. VEGF high expression existed more frequently in PRL, ACTH, FSH secreting and non-functioning PAs. The data of western blot also support the results. Spearman's rank correlation analysis showed that expression of MGMT was positively associated with D2R (r = 0.154, P = 0.031) and VEGF (r = 0.161, P = 0.024) in PAs, but no correlation was showed between D2R and VEGF expression (r = −0.025, P = 0.725 > 0.05). The association between their expression and clinical parameters was analyzed using a chi-squared test, or Fisher's exact probability test when appropriate, but the result showed no significant association. Conclusions PRL-and GH-secreting PAs exist high expression of D2R, responding to dopamine agonists; Most PAs exist low expression of MGMT and high expression of VEGF, TMZ or bevacizumab treatment could be applied under the premise of

  13. Measurement of isomeric yield ratios of 197m,gPt and 190m2,g+m1Ir from the 198Pt(γ,n) and natPt(γ,xn1p) reactions induced by 55-, 60-, and 65-MeV bremsstrahlung

    International Nuclear Information System (INIS)

    We have measured the isomeric yield ratios of 197m,gPt from the 198Pt(γ,n) reaction and 190m2,g+m1Ir from the natPt(γ,xn1p) reaction, induced with the bremsstrahlung end-point energies of 55-, 60-, and 65-MeV. The measurements were carried out by the activation method in combination with the direct γ-spectrometry. The experiments were performed at the 100 MeV electron linac of the Pohang Accelerator Laboratory (PAL). The obtained results at 55-, 60- and 65-MeV for the 197m,gPt from the 198Pt(γ,n) reaction are 0.166 ± 0.012, 0.174 ± 0.011, and 0.175 ± 0.011, whereas for the 190m2,g+m1Ir from the natPt(γ,xn1p) reaction are 0.072 ± 0.006, 0.084 ± 0.006 and 0.087 ± 0.006, respectively. The present results are measured for the first time over the investigated energy range. The present data are compared with the similar literature data at lower energy to examine the role of excitation energy

  14. Measurement of isomeric yield ratios of {sup 197m,g}Pt and {sup 190m2,g+m1}Ir from the {sup 198}Pt(γ,n) and {sup nat}Pt(γ,xn1p) reactions induced by 55-, 60-, and 65-MeV bremsstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Kye, Yong-Uk; Shin, Sung-Gyun [Department of Advanced Nuclear Engineering, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Cho, Moo-Hyun [Department of Advanced Nuclear Engineering, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Pohang Accelerator Laboratory, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Kim, Kyung Sook; Namkung, Won [Pohang Accelerator Laboratory, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Kim, Guinyun, E-mail: gnkim@knu.ac.kr [Department of Physics, Kyungpook National University, Daegu 702-701 (Korea, Republic of); Kim, Kwangsoo [Department of Physics, Kyungpook National University, Daegu 702-701 (Korea, Republic of); Kang, Yeong-Rok; Lee, Man-Woo [Research Center, Dongnam Institute of Radiological and Medical Sciences, Busan 619-953 (Korea, Republic of); Yang, Sung-Chul [Department of Physics, Kyungpook National University, Daegu 702-701 (Korea, Republic of); Korea Atomic Energy Research Institute, P.O. Box 105, Yusong, Daejon 305-600 (Korea, Republic of); Nguyen, Van Do; Pham, Duc Khue; Kim, Tien Thanh [Institute of Physics, Vietnam Academy of Science and Technology, 10 Dao Tan, Hanoi (Viet Nam); Naik, Haladhara [Radiochemistry Division, Bhabha Atomic Research Centre, Mumbai 400085 (India)

    2015-05-15

    We have measured the isomeric yield ratios of {sup 197m,g}Pt from the {sup 198}Pt(γ,n) reaction and {sup 190m2,g+m1}Ir from the {sup nat}Pt(γ,xn1p) reaction, induced with the bremsstrahlung end-point energies of 55-, 60-, and 65-MeV. The measurements were carried out by the activation method in combination with the direct γ-spectrometry. The experiments were performed at the 100 MeV electron linac of the Pohang Accelerator Laboratory (PAL). The obtained results at 55-, 60- and 65-MeV for the {sup 197m,g}Pt from the {sup 198}Pt(γ,n) reaction are 0.166 ± 0.012, 0.174 ± 0.011, and 0.175 ± 0.011, whereas for the {sup 190m2,g+m1}Ir from the {sup nat}Pt(γ,xn1p) reaction are 0.072 ± 0.006, 0.084 ± 0.006 and 0.087 ± 0.006, respectively. The present results are measured for the first time over the investigated energy range. The present data are compared with the similar literature data at lower energy to examine the role of excitation energy.

  15. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  16. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  17. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  18. 38 CFR 21.197 - “Interrupted” status.

    Science.gov (United States)

    2010-07-01

    ... record. (Authority: 38 U.S.C. 3117) (b) Assignment to “interrupted” status. A veteran's case will be... approximately established. (Authority: 38 U.S.C. 3110) (c) Reasons for assignment to “interrupted” status. A... to interrupted status, including: (i) A case in evaluation and planning status; (ii) A case...

  19. 1935 15' Quad #197 Aerial Photo Mosaic Index

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  20. 26 CFR 1.197-0 - Table of contents.

    Science.gov (United States)

    2010-04-01

    ... place. (4) Information base. (5) Know-how, etc. (6) Customer-based intangibles. (7) Supplier-based.... (10) Transactions subject to both anti-churning and nonrecognition rules. (11) Avoidance purpose....

  1. 46 CFR 197.340 - Breathing gas supply.

    Science.gov (United States)

    2010-10-01

    ...); and (4) Be grade A, B, or C. (h) Helium used for breathing mixtures must be grades A, B, or C produced...,000 parts per million of carbon dioxide; (ii) 20 parts per million carbon monoxide; (iii) 5 milligrams.... (f) Oxygen used for breathing mixtures must— (1) Meet the requirements of Federal Specification...

  2. 46 CFR 197.510 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ... Operating and Environmental Standards (CG-522), 2100 2nd St., SW., Stop 7126, Washington, DC 20593-7126 and... accordance with 5 U.S.C. 522(a) and 1 CFR part 51. To enforce any edition other than the one listed...

  3. Dynamics of Populations of Planetary Systems (IAU C197)

    Science.gov (United States)

    Knezevic, Zoran; Milani, Andrea

    2005-05-01

    1. Resonances and stability of extra-solar planetary systems C. Beaugé, N. Callegari, S. Ferraz-Mello and T. A. Michtchenko; 2. Formation, migration, and stability of extrasolar planetary systems Fred C. Adams; 3. Dynamical evolution of extrasolar planetary systems Ji-Lin Zhou and Yi-Sui Sun; 4. Dynamics of planetesimals: the role of two-body relaxation Eiichiro Kokubo; 5. Fitting orbits Andrzej J. Maciejewski, Krzysztof Gozdziewski and Szymon Kozlowski; 6. The secular planetary three body problem revisited Jacques Henrard and Anne-Sophie Libert; 7. Dynamics of extrasolar systems at the 5/2 resonance: application to 47 UMa Dionyssia Psychoyos and John D. Hadjidemetriou; 8. Our solar system as model for exosolar planetary systems Rudolf Dvorak, Áron Süli and Florian Freistetter; 9. Planetary motion in double stars: the influence of the secondary Elke Pilat-Lohinger; 10. Planetary orbits in double stars: influence of the binary's orbital eccentricity Daniel Benest and Robert Gonczi; 11. Astrometric observations of 51 Peg and Gliese 623 at Pulkovo observatory with 65 cm refractor N. A. Shakht; 12. Observations of 61 Cyg at Pulkovo Denis L. Gorshanov, N. A. Shakht, A. A. Kisselev and E. V. Poliakow; 13. Formation of the solar system by instability Evgeny Griv and Michael Gedalin; 14. Behaviour of a two-planetary system on a cosmogonic time-scale Konstantin V. Kholshevnikov and Eduard D. Kuznetsov; 15. Boundaries of the habitable zone: unifying dynamics, astrophysics, and astrobiology Milan M. Cirkovic; 16. Asteroid proper elements: recent computational progress Fernando Roig and Cristian Beaugé; 17. Asteroid family classification from very large catalogues Anne Lemaitre; 18. Non-gravitational perturbations and evolution of the asteroid main belt David Vokrouhlicky, M. Broz and W. F. Bottke, D. Nesvorny and A. Morbidelli; 19. Diffusion in the asteroid belt Harry Varvoglis; 20. Accurate model for the Yarkovsky effect David Capek and David Vokrouhlicky; 21. The population of asteroids in the 2:1 mean motion resonance with Jupiter revised Miroslav Broz, D. Vokrouhlicky, F. Roig, D. Nesvorny, W. F. Bottke and A. Morbidelli; 22. On the reliability of computation of maximum Lyapunov Characteristic Exponents for asteroids Zoran Knezevic and Slobodan Ninkovic; 23. Nekhoroshev stability estimates for different models of the Trojan asteroids Christos Efthymiopoulos; 24. The role of the resonant 'stickiness' in the dynamical evolution of Jupiter family comets A. Alvarez-Canda and F. Roig; 25. Regimes of stability and scaling relations for the removal time in the asteroid belt: a simple kinetic model and numerical tests Mihailo Cubrovic; 26. Virtual asteroids and virtual impactors Andrea Milani; 27. Asteroid population models Alessandro Morbidelli; 28. Linking Very Large Telescope asteroid observations M. Granvik, K. Muinonen, J. Virtanen, M. Delbó, L. Saba, G. De Sanctis, R. Morbidelli, A. Cellino and E. Tedesco; 29. Collision orbits and phase transition for 2004 AS1 at discovery Jenni Virtanen, K. Muinonen, M. Granvik and T. Laakso; 30. The size of collision solutions in orbital elements space G. B. Valsecchi, A. Rossi, A. Milani and S. R. Chesley; 31. Very short arc orbit determination: the case of asteroid 2004 FU162 Steven R. Chesley; 32. Nonlinear impact monitoring: 2-dimensional sampling Giacomo Tommei; 33. Searching for gravity assisted trajectories to accessible near-Earth asteroids Stefan Berinde; 34. KLENOT - Near Earth and other unusual objects observations Michal Kocer, Jana Tichá and M. Tichy; 35. Transport of comets to the Inner Solar System Hans Rickman; 36. Nongravitational Accelerations on Comets Steven R. Chesley and Donald K. Yeomans; 37. Interaction of planetesimals with the giant planets and the shaping of the trans-Neptunian belt Harold F. Levison and Alessandro Morbidelli; 38. Transport of comets to the outer p

  4. Re-evaluation of microscopic and integral cross-section data for important dosimetry reactions. Re-evaluation of the excitation functions for the 24Mg(n,p)24Na, 32S(n,p)32P, 60Ni(n,p)60m+gCo, 63Cu(n,2n)62Cu, 65Cu(n,2n)64Cu, 64Zn(n,p)64Cu, 115In(n,2n)114mIn, 127I(n,2n)126I, 197Au(n,2n)196Au and 199Hg(n,n')199mHg reactions

    International Nuclear Information System (INIS)

    Re-evaluations of cross sections and their associated covariance matrices have been carried out for ten dosimetry reactions: - excitation functions for the 63Cu(n,2n)62Cu, 65Cu(n,2n)64Cu, 64Zn(n,p)64Cu, 115In(n,2n)114mIn and 199Hg(n,n')199mHg reactions were re-evaluated over the neutron energy range from threshold to 20 MeV; - excitation functions for the 24Mg(n,p)24Na, 32S(n,p)32P and 60Ni(n,p)60m+gCo were reevaluated in the energy range from threshold to 21 MeV; - excitation functions for the 127I(n,2n)126I and 197Au(n,2n)196Au reactions were reevaluated in the energy range from threshold to 32 and 40 MeV, respectively. Benchmark calculations performed for 235U thermal fission and 252Cf spontaneous fission neutron spectra show that the integral cross sections derived from the newly evaluated excitation functions exhibit improved agreement with related experimental data when compared with the equivalent data from the IRDF-2002 library. (author)

  5. SU-E-T-197: Helical Cranial-Spinal Treatments with a Linear Accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, J; Bernard, D; Liao, Y; Templeton, A; Turian, J; Chu, J [Rush University Medical Center, Chicago, IL (United States)

    2014-06-01

    Purpose: Craniospinal irradiation (CSI) of systemic disease requires a high level of beam intensity modulation to reduce dose to bone marrow and other critical structures. Current helical delivery machines can take 30 minutes or more of beam-on time to complete these treatments. This pilot study aims to test the feasibility of performing helical treatments with a conventional linear accelerator using longitudinal couch travel during multiple gantry revolutions. Methods: The VMAT optimization package of the Eclipse 10.0 treatment planning system was used to optimize pseudo-helical CSI plans of 5 clinical patient scans. Each gantry revolution was divided into three 120° arcs with each isocenter shifted longitudinally. Treatments requiring more than the maximum 10 arcs used multiple plans with each plan after the first being optimized including the dose of the others (Figure 1). The beam pitch was varied between 0.2 and 0.9 (couch speed 5- 20cm/revolution and field width of 22cm) and dose-volume histograms of critical organs were compared to tomotherapy plans. Results: Viable pseudo-helical plans were achieved using Eclipse. Decreasing the pitch from 0.9 to 0.2 lowered the maximum lens dose by 40%, the mean bone marrow dose by 2.1% and the maximum esophagus dose by 17.5%. (Figure 2). Linac-based helical plans showed dose results comparable to tomotherapy delivery for both target coverage and critical organ sparing, with the D50 of bone marrow and esophagus respectively 12% and 31% lower in the helical linear accelerator plan (Figure 3). Total mean beam-on time for the linear accelerator plan was 8.3 minutes, 54% faster than the tomotherapy average for the same plans. Conclusions: This pilot study has demonstrated the feasibility of planning pseudo-helical treatments for CSI targets using a conventional linac and dynamic couch movement, and supports the ongoing development of true helical optimization and delivery.

  6. SDC muon barrel toroid 1/9.197 scale test model at SSC

    International Nuclear Information System (INIS)

    The purpose of the scale model for the muon barrel toroid (MBT) is to discover any problems in the preliminary design associated with the fabrication, assembly and installation. The information obtained from the model fabrication, assembly, installation, and testing processes will be used to evaluate the MBT preliminary design and to verify the finite element (FE) analysis. The final design of the MBT will take advantage of the experience gained from the test model to improve the design and engineering, fabrication methods, and assembly methods. The goals that are considered relevant to the test model include the following: Verify the in-plane and out-of-plane stiffness of the test model as predicted by the FE analysis. Verify the corner joint stiffness of the test model as predicted by the FE analysis. Verify the fabrication and assembly methods for the blocks, pins and keys on a small scale. Demonstrate the plate flattening scheme on a small scale. Insure that the preliminary design of the MBT can be assembled into the correct shape on a small scale. A magnetic measurement will be performed to record the field density inside an air gap. The main goal is to find out the field distribution for the test model due to geometry variation. The field measurements will also provide the information to verify the magnetic property of the steel material as well as the impact on the field distribution due to material variation

  7. 40 CFR 197.2 - What definitions apply in subpart A?

    Science.gov (United States)

    2010-07-01

    .... Spent nuclear fuel means fuel that has been withdrawn from a nuclear reactor following irradiation, the... radioactive waste means: (1) The highly radioactive material resulting from the reprocessing of spent nuclear... liquid waste that contains fission products in sufficient concentrations; and (2) Other...

  8. Statistical report of A-bomb survivors detailed health examinations October 197 - March 1976

    International Nuclear Information System (INIS)

    The subject was 82,705 persons, and the number of female was larger by about 16,000. The number of cases which were exposed to atomic bomb at places within 2.0 km far from the center of explosion was 476 (212 males and 264 females), and it was 10.2% of the total. With respect to a correlation of each item for general examinations estimated from the statistical values, the mean age of male was 52.9 years old, and correlations of age with the number of erythrocytes, blood sedimentation, and hemoglobin were high. The mean age of female was 53.3 years old, and a correlation of age with the maximum blood pressure was high, while correlations of age, with blood sedimentation, and hemoglobin were not so high. The number of leukocyte was directly proportional to urine sugar only in male. Correlation coefficients between urobilinogen and protein in urine were low in both female and male. A correlation between the maximum blood pressure and the minimum blood pressure was properly high, and the maximum blood pressure in both female and male was directly proportional to age. In female, both the maximum and minimum blood pressures were directly proportional to the number of erythrocytes and hemoglobin. There was the highest correlation between the distance from the center of explosion and the minimum blood pressure in female and male. Factor analysis made on the basis of the above-mentioned correlation matrix demonstrated that the first factor was erythrocyte, and the second factor was blood pressure. (Kanao, N.)

  9. Antithrombin gene Arg197Stop mutation-associated venous sinus thrombosis in a Chinese family

    Institute of Scientific and Technical Information of China (English)

    Ang Li; Dexin Wang; Qiming Xue; Baoen Wang; Tianhui Liu; Zhandong Liu; Jimei Li; Chunling Zhang; Jun Chen; Jinmei Sun; YanfeiHan; Lili Wang

    2011-01-01

    This study sought to elucidate the genetic correlation of cerebral venous sinus thrombosis caused by a hereditary antithrombin deficiency in a Chinese family, at the genetic and protein levels. A nonsense mutation from C to T on locus 6431 in exon 3B of the antithrombin gene was observed,leading to an arginine (CGA) to stop codon (TGA) change in the protein. This is the first report of this mutation in China. Ineffective heparin therapy in the propositus patient is associated with a lack of heparin binding sites after antithrombin gene mutation. Characteristic low intracranial pressure in the acute phase might be specific to this patient with cerebral venous sinus thrombosis.

  10. 197例供精人工授精患者的护理体会

    Institute of Scientific and Technical Information of China (English)

    杨春梅; 林小鸣; 游前

    2009-01-01

    @@ 供精人工授精(artificial insemination by donor,AID)是指通过非性交方式将供精者的精液注入于女性生殖道内,以期精子与卵子自然结合,达到生育目的而采用的一种辅助生育技术.

  11. Fission fragment mass distribution studies for 28Si + 197Au, 209Bi, 235U reactions

    International Nuclear Information System (INIS)

    In reactions with heavy ions, complete fusion and quasi-fission are the competing processes at energies above the Coulomb barrier. The quasi-fission process, in which the system reseparates before reaching a compact compound nucleus, is a major hurdle in forming heavy and superheavy evaporation residues (ER) in heavy-ion reactions. Fission fragment mass distribution for the fully equilibrated compound nucleus is decided at the scission point due to a long descent from saddle to scission. At higher excitation energies, the shell effects are washed out and the mass distribution is expected to be symmetric. The width of the distribution strongly depends on the entrance channel properties, such as mass asymmetry, deformation of interacting nuclei, collision energy, and the Coulomb factor Z1 Z2. Any sudden change in the width of the mass distribution would indicate departure from full equilibration, while onset of mass asymmetry or a sudden increase in width would be a strong signal of quasi fission

  12. 14 CFR Sec. 19-7 - Passenger origin-destination survey.

    Science.gov (United States)

    2010-01-01

    ... Class D—Restricted Business Class F—Unrestricted First Class G—Restricted First Class X—Restricted Coach... categories; namely C—Unrestricted Business Class, D—Restricted Business Class, F—Unrestricted First Class, G... Director, Office of Airline Information under the procedures in Sec. 1-2 of 14 CFR part 241. The......

  13. Clearance of mercury (HG-197, HG-203) vapor inhaled by human subjects

    International Nuclear Information System (INIS)

    Five human subjects inhaled a mixture of stable and radioactive mercury vapor for periods of 14 to 24 minutes. The subjects retained an average of 74 percent of that inhaled. Evidence is submitted to show that the retention occurred almost entirely in the alveoli. For 3 days after exposure, the exhaled breath was passed at intervals through activated charcoal traps for sampling periods of 10 to 35 minutes. The data indicated that an average of 7 percent of the retained mercury was lost in the expired breath, with a half time of 18 hours. Examination of the subjects in a whole body counter yielded average half times for mercury clearance from different parts of the body as follows: lung, 1.7 days; head, 21 days; kidney region, 64 days; chest, 43 days; and whole body, 58 days

  14. 46 CFR 197.206 - Substitutes for required equipment, materials, apparatus, arrangements, procedures, or tests.

    Science.gov (United States)

    2010-10-01

    ... particular equipment, material, apparatus, arrangement, procedure, or test is unreasonable or impracticable, the Commandant may permit the use of alternate equipment, material, apparatus, arrangement, procedure, or test to such an extent and upon such condition as will insure, to his satisfaction, a degree...

  15. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE,CERN

    OpenAIRE

    Rothe, Sebastian

    2012-01-01

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spec...

  16. Outer Membrane Protein Complex of Meningococcus Enhances the Antipolysaccharide Antibody Response to Pneumococcal Polysaccharide–CRM197 Conjugate Vaccine ▿

    OpenAIRE

    Lai, Zengzu; Schreiber, John R.

    2011-01-01

    Bacterial polysaccharides (PS) are T cell-independent antigens that do not induce immunologic memory and are poor immunogens in infants. Conjugate vaccines in which the PS is covalently linked to a carrier protein have enhanced immunogenicity that resembles that of T cell-dependent antigens. The Haemophilus influenzae type b (Hib) conjugate vaccine, which uses the outer membrane protein complex (OMPC) from meningococcus as a carrier protein, elicits protective levels of anti-capsular PS antib...

  17. http://www.ijecse.org/wp-content/uploads/2012/03/Volume-1Number-2PP-196-197.pdf

    Directory of Open Access Journals (Sweden)

    Er. Kailash Aseri

    2012-03-01

    Full Text Available A properly configured firewall is a good starting point in securing a computer network. However, complex network environments that involve higher number of participants and endpoints require better security infrastructure. Intrusion Detection Systems (IDS, proposed as a solution to perimeter defense, have many open problems and it is clear that better solutions must be found. Due to many unsolved problems associated with IDS, Intrusion Prevention Systems (IPS is introduced. The main idea in IPS is to be proactive. Network intrusion prevention system (NIPS becomes more complex due to the rapid growth of network bandwidth and requirement of network security. However existing solutions, either hardware-based or software-based cannot obtain a good tradeoff between performance and flexibility. In this paper, intrusion prevention can be used to and block malicious activity upon detection. To be specific intrusion prevention may involve dropping packets that can be considered malicious, blocking any traffic from an IP address that may be offending, sending alarms, resetting of connections, correcting cyclic redundancy errors etc.

  18. Book Review: "The Road to Sustainability, GDP and Future Generations" Pulselli et al, WIT Press, Southhampton, UK 197p 2008

    Science.gov (United States)

    “The Road to Sustainability, GDP and future generations” by Pulselli, F.M., Bastianoni, S., Marchettini, N. Tiezzi, E. was reviewed upon request by the journal’s editor. Briefly, this book presents the authors’ perspective on the complex and important topic of sustainability. Su...

  19. SU-E-J-197: Investigation of Microsoft Kinect 2.0 Depth Resolution for Patient Motion Tracking

    Energy Technology Data Exchange (ETDEWEB)

    Silverstein, E; Snyder, M [Wayne State University, Detroit, MI (United States)

    2015-06-15

    Purpose: Investigate the use of the Kinect 2.0 for patient motion tracking during radiotherapy by studying spatial and depth resolution capabilities. Methods: Using code written in C#, depth map data was abstracted from the Kinect to create an initial depth map template indicative of the initial position of an object to be compared to the depth map of the object over time. To test this process, simple setup was created in which two objects were imaged: a 40 cm × 40 cm board covered in non reflective material and a 15 cm × 26 cm textbook with a slightly reflective, glossy cover. Each object, imaged and measured separately, was placed on a movable platform with object to camera distance measured. The object was then moved a specified amount to ascertain whether the Kinect’s depth camera would visualize the difference in position of the object. Results: Initial investigations have shown the Kinect depth resolution is dependent on the object to camera distance. Measurements indicate that movements as small as 1 mm can be visualized for objects as close as 50 cm away. This depth resolution decreases linearly with object to camera distance. At 4 m, the depth resolution had decreased to observe a minimum movement of 1 cm. Conclusion: The improved resolution and advanced hardware of the Kinect 2.0 allows for increase of depth resolution over the Kinect 1.0. Although obvious that the depth resolution should decrease with increasing distance from an object given the decrease in number of pixels representing said object, the depth resolution at large distances indicates its usefulness in a clinical setting.

  20. Exclusive studies of angular distributions in GeV hadron-induced reactions with [sup 197]Au

    Energy Technology Data Exchange (ETDEWEB)

    Hsi, W.; Kwiatkowski, K.; Wang, G.; Bracken, D.S.; Cornell, E.; Ginger, D.S.; Viola, V.E. (Departments of Chemistry, Physics and IUCF, Indiana University, Bloomington, Indiana 47405 (United States)); Korteling, R.G. (Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, (Canada) V5A I56); Morley, K.B. (Physics Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)); Huang, R.; Lynch, W.G.; Tsang, M.B.; Xi, H. (Department of Physics and NSCL, Michigan State University, East Lansing, Michigan 48824 (United States)); Gimeno-Nogues, F.; Ramakrishnan, E.; Rowland, D.; Yennello, S.J. (Department of Chemistry and Cyclotron Institute, Texas A M University, College Station, Texas 77843 (United States)); Breuer, H. (Department of Physics, University of Maryland, College Park, Maryland 20740 (United States)); Gushue, S.; Remsberg, L.P. (Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 (United States)); Botvin

    1999-09-01

    Exclusive studies of angular distributions for intermediate-mass fragments (IMFs) produced in GeV hadron-induced reactions have been performed with the Indiana Silicon Sphere (ISiS) 4[pi] detector array. Special emphasis has been given to understanding the origin of sideways peaking, which becomes prominent in the angular distributions for beam momenta above about 10 GeV/c. Both the magnitude of the effect and the peak angle increase as a function of fragment multiplicity and charge. When gated on IMF kinetic energy, the angular distributions evolve from forward-peaked to near isotropy as the fragment kinetic energy decreases. Fragment-fragment angular-correlation analyses show no obvious evidence for a dynamic mechanism that might signal shock wave effects or the breakup of exotic geometric shapes such as bubbles or toroids. Moving-source and intranuclear cascade simulations suggest that the observed sideways peaking is of kinematic origin, arising from significant transverse momentum imparted to the heavy recoil nucleus during the fast cascade stage of the collision. A two-step cascade and statistical multifragmentation calculation is consistent with this assumption. [copyright] [ital 1999] [ital The American Physical Society

  1. Exclusive studies of angular distributions in GeV hadron-induced reactions with {sup 197}Au

    Energy Technology Data Exchange (ETDEWEB)

    Hsi, W.; Kwiatkowski, K.; Wang, G.; Bracken, D.S.; Cornell, E.; Ginger, D.S.; Viola, V.E. [Departments of Chemistry, Physics and IUCF, Indiana University, Bloomington, Indiana 47405 (United States); Korteling, R.G. [Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, (Canada) V5A I56; Morley, K.B. [Physics Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Huang, R.; Lynch, W.G.; Tsang, M.B.; Xi, H. [Department of Physics and NSCL, Michigan State University, East Lansing, Michigan 48824 (United States); Gimeno-Nogues, F.; Ramakrishnan, E.; Rowland, D.; Yennello, S.J. [Department of Chemistry and Cyclotron Institute, Texas A M University, College Station, Texas 77843 (United States); Breuer, H. [Department of Physics, University of Maryland, College Park, Maryland 20740 (United States); Gushue, S.; Remsberg, L.P. [Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 (United States); Botvina, A. [Department of Physics, University of Bologna, Bologna I-40126 (Italy); Friedman, W.A. [Department of Physics, University of Wisconsin, Madison, Wisconsin 53706 (United States)

    1999-09-01

    Exclusive studies of angular distributions for intermediate-mass fragments (IMFs) produced in GeV hadron-induced reactions have been performed with the Indiana Silicon Sphere (ISiS) 4{pi} detector array. Special emphasis has been given to understanding the origin of sideways peaking, which becomes prominent in the angular distributions for beam momenta above about 10 GeV/c. Both the magnitude of the effect and the peak angle increase as a function of fragment multiplicity and charge. When gated on IMF kinetic energy, the angular distributions evolve from forward-peaked to near isotropy as the fragment kinetic energy decreases. Fragment-fragment angular-correlation analyses show no obvious evidence for a dynamic mechanism that might signal shock wave effects or the breakup of exotic geometric shapes such as bubbles or toroids. Moving-source and intranuclear cascade simulations suggest that the observed sideways peaking is of kinematic origin, arising from significant transverse momentum imparted to the heavy recoil nucleus during the fast cascade stage of the collision. A two-step cascade and statistical multifragmentation calculation is consistent with this assumption. {copyright} {ital 1999} {ital The American Physical Society}

  2. Colación del MS. 197 (P. Vergilii Maronis Bucolica Georgicon Aeneidos) del Archivo Capitular de Vic

    OpenAIRE

    Librán Moreno, Myriam

    2005-01-01

    La autora presenta la primera colación del manuscrito virgiliano más antiguo de los custodiados en España (s. XI), que ha denominado Ausonensis. Concluye que es conveniente tener en cuenta este manuscrito en futuras ediciones de Virgilio.

  3. Tivantinib (ARQ-197) exhibits anti-tumor activity with down-regulation of FAK in oral squamous cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Xi, Wei-Hong [Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Nanchang University, Nanchang 330006 (China); Yang, Li-Yun [Department of Blood Transfusion, First Affiliated Hospital, Nanchang University, Nanchang 330006 (China); Cao, Zhong-Yi, E-mail: m18070383032@163.com [Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Nanchang University, Nanchang 330006 (China); Qian, Yong, E-mail: yfykqkqy@163.com [Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, Nanchang University, Nanchang 330006 (China)

    2015-02-20

    Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide and the 5 years survival rate of the patients is about 60% in the USA, due to acquired chemotherapeutic resistance and metastasis of the disease. In this study, we found that tivantinib, a selective MET inhibitor, suppresses OCSS cell proliferation and colony formation, however, anti-tumor activities induced by tivantinib are independent of the inhibition of MET signaling pathway. In addition, tivantinib cause G2/M cell cycle arrest and caspases-dependent apoptosis in OSCC cell lines. We also found that tivantinib dose-dependently suppressed the activation and expression of FAK. In all, these data suggested that tivantinib may be developed as a chemotherapeutic agent to effectively treat certain cancers including OSCC. - Highlights: • Tivantinib suppresses OSCC cell growth independent of the inhibition of HGF/MET signaling pathway. • Tivantinib blocks cell cycle and induces caspases-mediated apoptosis. • Tivantinib elicits its anti-tumor activity with the inhibition of FAK signaling pathway.

  4. Energetic particle emission and linear momentum transfer in central collisions induced by 32.5 MeV/nucleon 16O + 238U, 197Au

    International Nuclear Information System (INIS)

    Reaction kinetics of incomplete fusion reactions between heavy nuclei of Oxygen and Uranium and Oxygen and Gold are studied at 32.5 MeV bombarding energy to gain information about linear momentum transfer. It is found that the most probable linear momentum transfer is only about 75% of the beam momentum for these reactions. Binary massive transfer mechanisms and prompt nucleon emission are offered as explanations of this phenomena. It appears that nuclear mean field dynamics rather than nucleon-nucleon phenomenon dominate reaction kinetics at this bombarding energy. 5 refs., 8 figs

  5. Fabrice Audié, Spinoza et les mathématiques, Paris, PUPS, 2005, 197 pages, 18 €.

    Directory of Open Access Journals (Sweden)

    Cécile Nicco

    2007-01-01

    Full Text Available Si, comme le souligne Pierre-François Moreau dans la préface, le rapport de la philosophie spinoziste aux mathématiques est « fort visible », il n’est pas pour autant facile à interpréter. En effet, l’intérêt de Spinoza pour les mathématiques est manifeste dans la forme géométrique de l’Éthique, des Principes de la philosophie de Descartes, et du premier Appendice du Court Traité ; mais elles sont aussi présentes en tant que problèmes à traiter ou comme illustrations dans la correspondance et...

  6. Supplement to 'ASDEX Upgrade, definition of a tokamak experiment with a reactor-compatible poloidal divertor' (IPP-report 1/197, March 1982)

    International Nuclear Information System (INIS)

    Since March 1982 the better understanding of the divertor physics, both by theory and experiments, and the development of the ASDEX Upgrade concept have considerably improved and simplified the ASDEX Upgrade design. Single null poloidal divertor configurations were calculated, which can well compete with elongated limiter configurations in reduced poloidal field effort. The role of recycling and its limitation set by the available energy flux, observed experimentally and explained by a plasma boundary flow model, led to a refined formulation of the line density requirements. Finally, a discussion of the attainable temperature and densities allowed clearly to distinguish between ASDEX and ASDEX Upgrade and pointed out the dominant role of the plasma current. The ASDEX Upgrade basic data are summarized as presented to the EURATOM advisory board. (orig.)

  7. {sup 3}He induced reactions on {sup nat}Ag and {sup 197}Au at 1.8, 3.6 and 4.8 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Brzychczyk, J. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l`Instrumentation Associee]|[Jagiellonian Univ., Krakow (Poland). Inst. of Physics; Pollacco, E.C.; Volant, C.; Legrain, R. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l`Instrumentation Associee; Kwiatkowski, K.; Morley, K.B.; Renshaw-Foxford, E.; Bracken, D.S.; Viola, V.E.; Yoder, N.R. [Indiana Univ., Bloomington, IN (United States). Dept. of Chemistry] [and others

    1995-03-01

    The {sup 3}He induced reactions on Ag and Au are studied using a large solid angle and low energy threshold detector array. The data show consistency with intranuclear cascade and expanding emitting source description. Charge moment analysis is presented. (author). 18 refs., 8 figs.

  8. Fragment charge and energy distributions in the 1.8-4.8 GeV {sup 3}He + {sup nat}Ag, {sup 197}Au reactions

    Energy Technology Data Exchange (ETDEWEB)

    Bracken, D.S.; Foxford, E.R.; Kwiatkowski, K. [and others

    1995-10-01

    Moving source fits have been performed for IMFs as a function of observables related to collision violence in the 1.8-4.8 GeV {sup 3}He +{sup nat}Ag, {sup l97}Au reactions. The systematic behavior of the source properties and fragment charge distributions will be reviewed. The evolution of the spectral Coulomb parameters provides evidence for nuclear expansion prior to multifragmentation, suggesting a breakup density of p/p{sub o} {approximately} 1/3. The charge distributions will be examined in terms of power-law fits and moment analyses.

  9. Fragment charge and energy distributions in the 1.8-4.8 GeV 3He + natAg, 197Au reactions

    International Nuclear Information System (INIS)

    Moving source fits have been performed for IMFs as a function of observables related to collision violence in the 1.8-4.8 GeV 3He +natAg, l97Au reactions. The systematic behavior of the source properties and fragment charge distributions will be reviewed. The evolution of the spectral Coulomb parameters provides evidence for nuclear expansion prior to multifragmentation, suggesting a breakup density of p/po ∼ 1/3. The charge distributions will be examined in terms of power-law fits and moment analyses

  10. Study of hadronic event shape in flavour tagged events in $e^{+} e^{-}$ annihilation at $<\\sqrt{S}>$ = 197 GeV

    CERN Document Server

    Achard, P; Aguilar-Benítez, M; Alcaraz, J; Alemanni, G; Allaby, J; Aloisio, A; Alviggi, M G; Anderhub, H; Andreev, V P; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Bajo, A; Baksay, G; Baksay, L; Baldew, S V; Banerjee, S; Banerjee, Sw; Barczyk, A; Barillère, R; Bartalini, P; Basile, M; Batalova, N; Battiston, R; Bay, A; Becker, U; Behner, F; Bellucci, L; Berbeco, R; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biglietti, M; Biland, A; Blaising, J J; Blyth, S C; Bobbink, G J; Böhm, A; Boldizsar, L; Borgia, B; Bottai, S; Bourilkov, D; Bourquin, M; Braccini, S; Branson, J G; Brochu, F; Burger, J D; Burger, W J; Cai, X D; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A; Casaus, J; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada, M; Chamizo-Llatas, M; Chang, Y H; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chiefari, G; Cifarelli, L; Cindolo, F; Clare, I; Clare, R; Coignet, G; Colino, N; Costantini, S; de la Cruz, B; Cucciarelli, S; De Asmundis, R; Déglon, P; Debreczeni, J; Degré, A; Dehmelt, K; Deiters, K; Della Volpe, D; Delmeire, E; Denes, P; De Notaristefani, F; De Salvo, A; Diemoz, M; Dierckxsens, M; Dionisi, C; Dittmar, M; Doria, A; Dova, M T; Duchesneau, D; Duda, M; Echenard, B; Eline, A; El-Hage, A; El-Mamouni, H; Engler, A; Eppling, F J; Extermann, P; Falagán, M A; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, M; Ferguson, T; Fesefeldt, H; Fiandrini, E; Field, J H; Filthaut, F; Fisher, P H; Fisher, W; Forconi, G; Freudenreich, K; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gataullin, M; Gentile, S; Giagu, S; Gong, Z F; Grenier, G; Grimm, O; Grünewald, M W; Gupta, V K; Gurtu, A; Gutay, L J; Haas, D; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Hirschfelder, J; Hofer, H; Hohlmann, M; Holzner, G; Hou, S R; Jin, B N; Jindal, P; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kaur, M; Kienzle-Focacci, M N; Kim, J K; Kirkby, J; Kittel, W; Klimentov, A; König, A C; Kopal, M; Koutsenko, V; Kräber, M; Krämer, R W; Krüger, A; Kunin, A; Ladrón de Guevara, P; Laktineh, I; Landi, G; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Le Goff, J M; Leiste, R; Levtchenko, M; Levchenko, P M; Li, C; Likhoded, S; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lü, Y S; Luci, C; Luminari, L; Lustermann, W; Ma, W G; Malgeri, L; Malinin, A; Maña, C; Mans, J; Martin, J P; Marzano, F; Mazumdar, K; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Mihul, A; Milcent, H; Mirabelli, G; Mnich, J; Mohanty, G B; Muanza, G S; Muijs, A J M; Musy, M; Nagy, S; Natale, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nisati, A; Novák, T; Nowak, H; Ofierzynski, R; Organtini, G; Pal, I; Palomares, C; Paolucci, P; Paramatti, R; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, F; Pedace, M; Pensotti, S; Perret-Gallix, D; Piccolo, D; Pierella, F; Pieri, M; Pioppi, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Pothier, J; Prokofiev, D; Rahal-Callot, G; Rahaman, M A; Raics, P; Raja, N; Ramelli, R; Rancoita, P G; Ranieri, R; Raspereza, A; Razis, P; Rembeczki, S; Ren, D; Rescigno, M; Reucroft, S; Riemann, S; Riles, K; Roe, B P; Romero, L; Rosca, A; Rosemann, C; Rosenbleck, C; Rosier-Lees, S; Roth, S; Rubio, J A; Ruggiero, G; Rykaczewski, H; Sakharov, A; Saremi, S; Sarkar, S; Salicio, J; Sánchez, E; Schäfer, C; Schegelsky, V; Schopper, H; Schotanus, D J; Sciacca, C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shumilov, E; Shvorob, A; Son, D; Souga, C; Spillantini, P; Steuer, M; Stickland, D P; Stoyanov, B; Strässner, A; Sudhakar, K; Sultanov, G G; Sun, L Z; Sushkov, S; Suter, H; Swain, J D; Szillási, Z; Tang, X W; Tarjan, P; Tauscher, L; Taylor, L; Tellili, B; Teyssier, D; Timmermans, C; Ting, Samuel C C; Ting, S M; Tonwar, S C; Tóth, J; Tully, C; Tung, K L; Ulbricht, J; Valente, E; Van de Walle, R T; Vásquez, R; Vesztergombi, G; Vetlitskii, I; Viertel, G; Vivargent, M; Vlachos, S; Vodopyanov, I; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Wadhwa, M; Wang, Q; Wang, X L; Wang, Z M; Weber, M; Wynhoff, S; Xia, L; Xu, Z Z; Yamamoto, J; Yang, B Z; Yang, C G; Yang, H J; Yang, M; Yeh, S C; Zalite, A; Zalite, Yu; Zhang, Z P; Zhao, J; Zhu, G Y; Zhu, R Y; Zhuang, H L; Zichichi, A; Zimmermann, B; Zöller, M

    2008-01-01

    Results are presented from a study of the structure of hadronic events in highenergy (e^+)(e^-) interactions detected by the L3 detector at LEP. Various event shape distributions and their moments are measured at several energy points at and above the Z-boson mass. The event avour is tagged by using the decay characteristics of b-hadrons. Measurements of distributions of event shape variables for all hadronic events, for light (u, d, s, c) and heavy (b) quark avours are compared to several QCD models with improved leading log approximation: Jetset, Herwig and Ariadne. A good description of the data is provided by the models.

  11. Projeto sala de espera: uma proposta para a educação em diabetes - doi:10.5020/18061230.2006.p197

    Directory of Open Access Journals (Sweden)

    Clarisse Mourão Melo Ponte

    2012-01-01

    Full Text Available A educação é um aspecto fundamental do cuidado do diabético. Para tal, várias estratégias têm sido buscadas. Os objetivos do presente estudo foram descrever o “Projeto Sala de Espera”, uma proposta que se baseia na utilização do período em que o paciente aguarda o atendimento individual para promover educação em diabetes; e avaliar o perfil clínico-epidemiológico dos diabéticos participantes deste projeto. Foram realizadas 20 reuniões, de março a outubro de 2006, com 350 pacientes seguidos no Ambulatório de Diabetes, do Hospital Universitário Walter Cantídio - UFC e seus acompanhantes. Desses, 76 pacientes, selecionados aleatoriamente, foram entrevistados. As reuniões ocorriam a cada sexta-feira, em 2 sessões de aproximadamente meia-hora, que eram dirigidas por equipe uma multidisciplinar, e contavam com 25 participantes em cada. Ao término, era servido um café da manhã, o qual era utilizado para a educação nutricional. Entre os entrevistados, predominaram mulheres (85,5%, com média de idade 60,4±9,1 anos e tempo médio de diagnóstico de 10,6±5,9anos. Em relação ao tratamento, dos participantes, 40,7% usavam insulina; 63,1% antidiabéticos orais e 9,2% adotavam apenas mudanças no estilo de vida. A adesão às drogas era contínua em apenas 47,8% e a maioria (67,1% não praticava atividades físicas. Quanto a dietoterapia, somente 31,5% aderiam plenamente. Mais de 75% dos avaliados eram alfabetizados e recebiam um salário mínimo ou menos. A partir das observações oriundas da prática, pode-se perceber: maior motivação dos pacientes após cada reunião, participação mais ativa nas consultas médicas e um crescente interesse sobre a sua enfermidade e o seu cuidado. Proporcionar a participação do diabético no seu tratamento, estimulando o autocuidado, é um desafio a ser alcançado por todos os serviços de saúde e que pode ser facilitada com a utilização de propostas como a descrita.

  12. Development of Optical Fiber Technology in Poland, International Journal of Electronics and Telecommunication, vol. 57, no 2, pp.191-197, July 2011

    CERN Document Server

    Dorosz, J

    2011-01-01

    In this paper, the authors, chairmen of the 13th Conference on Optical Fibers and Their Applications OFA2011, and editors of the conference proceedings summarize the development of optical fiber technology in Poland (during the period of 2009- 2011) on the basis of papers presented there and consecutively published in this volume. The digest is thus not full but covers the periodically presented material every 18 months during the meetings on optical fibers in Białystok-Białowie˙za and Lublin- Krasnobród. OFC systems are developed for HEP experiments and accelerators. OFC systems are also developed for virtual atomic clocks. EuCARD information presentation was organized during this meeting. Keywords— optical fibers, optical communication systems, photonic sources and detectors, photonic sensors, integrated optics, photonics applications, photonic materials.

  13. Fission of spin-aligned projectile-like nuclei in the interactions of 29 MeV/nucleon 208Pb with 197Au

    International Nuclear Information System (INIS)

    Binary fission of projectile-like nuclei was investigated in the interaction of 29 MeV/nucleon Pb on Au, together with the associated neutron multiplicity. Fission is only observed in rather peripheral collisions and represents approximately 20% of the total reaction cross-section. The fission process occurs after collisions in which up to 550 MeV have been dissipated. The angular and energy distribution of the fragments can be accounted for by assuming a noticeable spin alignment of the fissioning nuclei. (author) 18 refs.; 3 figs

  14. Compound list: simvastatin [Open TG-GATEs

    Lifescience Database Archive (English)

    Full Text Available simvastatin SST 00117 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/simv...astatin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/simv...astatin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/simv...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/simvastatin.Rat.in_vivo.Liver.Repeat.zip ...

  15. Measure of thermal neutron flux in the IPEN/MB-01 reactor using {sup 197} Au wire activation detectors; Medida do fluxo de neutrons termicos do reator IPEN/MB-01 com detectores de ativacao de fios de {sup 197} Au

    Energy Technology Data Exchange (ETDEWEB)

    Marques, Andre Luis Ferreira

    1995-12-31

    This dissertation has aimed at developing a neutron flux measurement technique by means of detectors activation analysis. The main task of this work was the implementation of this thermal neutron flux measurement technique, using gold wires as activation detectors in the IPEN/MB-01 reactor core. The neutron thermal flux spatial distribution was obtained by gold wire activation technique, with wire diameters of 0.125 mm and 0.250 mm in seven selected reactor experimental channels. The values of thermal flux were about 10{sup 9} neutrons/cm{sup 2}.s. This experiment has been the first one conducted with gold wires in the IPEN/MB-01 reactor, being this technique implemented for use by experiments in flux mapping of the core 73 refs., 60 figs., 31 tabs.

  16. Multibeam collection for KN197-08: Multibeam data collected aboard Knorr from 2010-05-22 to 2010-06-24, departing from Bridgetown, Barbados and returning to Bridgetown, Barbados

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  17. Yinsheng Tian, Kai Gu, and Wei Tao (eds.. Urban Morphology, Architectural Typology and Cities in Transition. 197 p. ISBN: 978-7-03-040218-9. 2014. Science Press, Beijing.

    Directory of Open Access Journals (Sweden)

    Mildred Moreno Villanueva

    2015-08-01

    Full Text Available Como resultado de las reformas económicas que se han venido implementando en China desde 1978, la tasa de urbanización de ese país se ha incrementado desde un 18% a alrededor del 50%. Es decir, que actualmente la población urbana de China (más de 650 millones de personas representa más del doble de la población total de los Estados Unidos. Tomando este proceso como eje, en el libro se presenta el estado del arte de la investigación sobre la forma urbana en ese país en lo que respecta a las ciudades tradicionales, las ciudades tempranas de la modernidad, las ciudades socialistas y del periodo post-reforma, así como la preservación histórica, la conservación, y la investigación sobre tipologías de vivienda tradicional en China.

  18. « The Sasanian Relashionship with South Arabia: Literary, Epigraphic and Oral Historical Perspectives ». Arabian Archaeology and Epigraphy 37, fasc. 2, 2008, p. 197-213.

    OpenAIRE

    Cuny, Julien

    2013-01-01

    L’A. offre un compendium de trois types de sources différentes concernant l’histoire de l’intervention, de la présence ou de l’impact du pouvoir sassanide en Arabie : les sources littéraires (essentiellement arabo-persanes mais aussi romano-byzantines) ; les quelques inscriptions disponibles, une lapidaire himyarite, et une documentationsigillographique mais qui ne se réfère pas explicitement à l’Arabie; ainsi que la tradition orale omanaise. Néanmoins, le propos de l’A. ne se limite pas à l’...

  19. Cédric Lomba et Julian Mischi, « Usines. Ouvriers, militants, intellectuels », Actes de la recherche en sciences sociales, n° 196-197, mars 2013

    OpenAIRE

    Quijoux, Maxime

    2013-01-01

    Dans un contexte social marqué par la multiplication des restructurations et la destruction massive d’emplois industriels, la dernière parution des Actes constitue non seulement une livraison bienvenue sur le monde ouvrier, mais judicieuse au regard de l’approche choisie. Bienvenue, car, si les mobilisations ouvrières suscitent aujourd’hui une intense couverture médiatique, l’usine et ses acteurs ont connu une relégation importante en tant qu’objet d’étude dans les sciences sociales. Pertinen...

  20. Results from two years of Matricaria inodora L. and Matricaria chamomilla L. monitoring (2012 + 2013) – greenhouse efficacy trials with Tribenuron and Florasulam and ALS target site resistance test at Pro 197 and Thr 574

    OpenAIRE

    Tiede, Anke; Dzikowski, Marcin; Becker, Jörg; Wittrock, Arndt

    2014-01-01

    The first ALS resistant Matricaria chamomilla (MATCH) biotype was found in 2006 in Schleswig Holstein in Witzwort (SCHLEICH-SAIDFAR et al., 2011). Since 2006 ALS resistant Matricaria chamomilla and Matricaria inodora (MATIN) were found at other locations near the North Sea coastline in Schleswig-Holstein and Lower Saxony (ULBER et al., 2012). As there were more and more cases of reduced efficacy of sulfonylureas on mayweed, Dow AgroSciences decided in 2012 and 2013 to test MATCH and MATIN sam...

  1. The expression profile of Dopamine D2 receptor, MGMT and VEGF in different histological subtypes of pituitary adenomas: a study of 197 cases and indications for the medical therapy

    OpenAIRE

    Wang, Youwei; Li, Junyang; TOHTI, MAMATEMIN; Hu, Yuebing; Wang, Sheng; Li, Wanchun; LU, ZHENFENG; Ma, Chiyuan

    2014-01-01

    Background To study the expression of D2R, MGMT and VEGF for clinical significance in pituitary adenomas, and to predict the potential curative medical therapy of dopamine agonists, temozolomide and bevacizumab on pituitary adenomas. Methods Immunohistochemistry and western blot were performed to detect the expression of expression of D2R, MGMT and VEGF in pituitary adenoma tissue samples. The ratio of high expression of D2R, MGMT or VEGF in different subtypes of PA was compared by the use of...

  2. Multibeam collection for KN197-04: Multibeam data collected aboard Knorr from 2010-02-19 to 2010-03-12, departing from Bridgetown, Barbados and returning to Fortaleza, Brazil

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  3. Multibeam collection for KN197-10: Multibeam data collected aboard Knorr from 2010-07-10 to 2010-08-01, departing from Ponta Delgada, Azores and returning to Woods Hole, MA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  4. 197荞麦多酚对谷氨酸和红藻氨酸诱导的海马神经元死亡的抑制作用

    Institute of Scientific and Technical Information of China (English)

    喻剑华

    2005-01-01

    @@ 荞麦Fagopyrum esculentum Moench多酚(BWP)具有改善大鼠空间记忆损害和反复脑缺血造成的细胞凋亡等作用,但作用机理不明.作者研究了BWP对谷氨酸和红藻氨酸致原代培养海马神经元死亡的作用.

  5. Structural Properties of Nonstoichiometric Barium and Strontium Peroxides: BaO 2- x (1.97≥2- x≥1.72) and SrO 2- x (1.98≥2- x≥1.90)

    Science.gov (United States)

    Königstein, Markus

    1999-11-01

    The crystal structures of eight single crystals of barium and strontium peroxide, prepared by high pressure-high temperature synthesis, were determined by X-ray diffraction. The crystallographic data were successfully refined in the calcium carbide structure (space group I4/mmm, Z=2). The results clearly indicate that the peroxides are nonstoichiometric compounds, MO2-x (M=Ba, Sr), with a peroxide deficiency and that oxide ions are present on interstitial lattice sites. The composition rage extends from near stoichiometry to compounds with a total oxygen content of 1.72 in the barium and 1.90 in the strontium peroxide. We find that the oxide ions, replacing the peroxide molecular ions, occupy an interstitial position that is in the middle of the replaced peroxide molecular ion. A decrease of the peroxide content in the crystals results in a decreased c-axis of the tetragonal unit cell of the structure, while the a-axis is almost constant. Furthermore, the peroxide bond length decreases, as was confirmed by Raman spectroscopy.

  6. Deep-UV high resolution cavity ring-down spectroscopy of the Schumann-Runge bands in O-16(2) and O-18(2) at wavelengths 197-203 nm

    NARCIS (Netherlands)

    Hannemann, S.; Duijn, van E.J.; Ubachs, W.M.G.

    2005-01-01

    With the use of a novel titanium: sapphire laser source delivering, upon fourth harmonic generation, narrowband and tunable radiation in the deep-UV, spectroscopic studies were performed on weak Schumann-Runge bands of oxygen. Improved values for rotational and fine structure molecular parameters fo

  7. Multibeam collection for KN197-06: Multibeam data collected aboard Knorr from 2010-04-04 to 2010-04-23, departing from Cape Town, South Africa and returning to Cape Town, South Africa

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  8. Multibeam collection for KN197-05: Multibeam data collected aboard Knorr from 2010-03-14 to 2010-03-28, departing from Fortaleza, Brazil and returning to Cape Town, South Africa

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  9. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1995-12-01

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

  10. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity...

  11. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Science.gov (United States)

    2010-01-01

    .... Actinium Ac 89 Aluminum Al 13 Americium Am 95 Antimony Sb 51 Argon Ar 18 Arsenic As 33 Astatine At 85... Curium Cm 96 Dysprosium Dy 66 Einsteinium Es 99 Erbium Er 68 Europium Eu 63 Fermium Fm 100 Fluorine F...

  12. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    International Nuclear Information System (INIS)

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons

  13. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  14. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  15. Production cross section of At radionuclides from $^{7}$Li+$^{\\textrm{nat}}$Pb and $^{9}$Be+$^{\\textrm{nat}}$Tl reactions

    CERN Document Server

    Maiti, Moumita

    2011-01-01

    Earlier we reported theoretical studies on the probable production of astatine radionuclides from $^{6,7}$Li and $^{9}$Be-induced reactions on natural lead and thalliun targets, respectively. For the first time, in this report, production of astatine radionuclides has been investigated experimentally with two heavy ion induced reactions: $^{9}$Be+$^{\\textrm{nat}}$Tl and $^{7}$Li+$^{\\textrm{nat}}$Pb. Formation cross sections of the evaporation residues, $^{207,208,209,210}$At, produced in (HI, xn) channel, have been measured by the stacked-foil technique followed by the off-line $\\gamma$-spectrometry at the low incident energies ($<$50 MeV). Measured excitation functions have been explained in terms of compound nuclear reaction mechanism using Weisskopf-Ewing and Hauser-Feshbach model. Absolute cross section values are lower than the respective theoretical predictions.

  16. New data on cross-sections of deuteron induced nuclear reactions on gold up to 50 MeV and comparison of production routes of medically relevant Au and Hg radioisotopes

    CERN Document Server

    Tárkányi, F; Ditrói, F; Takács, S; Adam-Rebeles, R

    2016-01-01

    Investigations of cross-sections of deuteron induced nuclear reactions on gold were extended up to 50 MeV by using the standard stacked foil irradiation technique and high resolution gamma-ray spectrometry. New cross-sections are reported for the $^{197}$Au(d,xn)$^{197m,197g,195m,195g,193m,193g}$Hg and $^{197}$Au(d,x)$^{198m,198g,196m,196g,195,194}$Au nuclear reactions. The application for production of the medically relevant isotopes $^{198}$Au and $^{195m,195g,197m,197g}$Hg is discussed, including the comparison with other charged particle induced production routes. The possible use of the $^{197}$Au(d,x)$^{197m,197g,195m,193m}$Hg and $^{196m,196g}$Au reactions for monitoring deuteron beam parameters is also investigated.

  17. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  18. Vespignani, Giorgio, Iппoδρoμoς. Il circo di Costantinopoli nuova Roma dalla realtà alla storiografia, Fondazione Centro Italiano di Studi sull"Alto Medioevo, Spoleto, 2010, 303 páginas. ISBN: 978 88-7988-197-5

    OpenAIRE

    Jiménez Sánchez, Juan Antonio

    2010-01-01

    "El Circo Máximo es su templo, su hogar, su asamblea y la esperanza de todos sus deseos" (AmmiAnvs mArc., Res gest., XXVIII, 4, 29: eisque templum et habitaculum et contio et cupitorum spes omnis Circus est maximus). De este modo describió el historiador Amiano Marcelino, hacia el 382/397, la pasión que la plebe de Roma sentía hacia los espectáculos, especialmente hacia los ludi circenses. Se trata de una afición que se fue incrementando a lo largo de toda la historia del Imperio Romano, hast...

  19. Gclust Server: 35945 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 35945 Rle_pRL70119 Cluster Sequences - 197 putative crown-gall tumour like protein ...uences Cluster Sequences Link to related sequences - Sequence length 197 Representative annotation putative crown

  20. AcEST: DK960181 [AcEST

    Lifescience Database Archive (English)

    Full Text Available _BACCI Cyclodextrin glucanotransferase OS=Bacill... 44 0.004 tr|Q197W1|Q197W1_9BACI Beta-cyclodextrin glycos...ery: 228 YIGSNLNITVPVNST-TVYIQW 290 G+N T P + T T+ + W Sbjct: 690 EGGANRTFTTPTSGTATMNVNW 711 >tr|Q197W1|Q197W1_9BACI Beta-cyclodextri

  1. 46 CFR Appendix C to Subpart C to... - Medical Surveillance Guidelines for Benzene

    Science.gov (United States)

    2010-10-01

    ... principal effects of benzene exposure addressed in 46 CFR part 197, subpart C, appendix A, are pathological... specified in 46 CFR 197.560 is designed to observe, on a regular basis, blood indices for early signs of... required in 46 CFR 197.560. There are special provisions for medical tests in the event of...

  2. 33 CFR 154.820 - Fire, explosion, and detonation protection.

    Science.gov (United States)

    2010-07-01

    ...: (1) Have a detonation arrester located not more than 6 meters (19.7 ft.) from the facility vapor... detonation arrester located not more than 6 meters (19.7 ft.) from the facility vapor connection; or (2) Have...) Have a detonation arrester located not more than 6 meters (19.7 ft.) from the facility vapor...

  3. Inclusive measurement of (p,πsup(-)xn) double charge exchange reactions on bismuth from threshold to 800 MeV

    International Nuclear Information System (INIS)

    The energy dependence of the total angle-integrated cross section for the production of astatine isotopes from (p,πsup(-)xn) double charge exchange reactions on bismuth (sup(209)Bi) was measured from 120 to 800 MeV using activation and radiochemical techniques. Chemical yields were estimated by direct radioassaying of sup(211)At activity in thin (approximately 1 mg/cmsup(2)), irradiated bismuth targets. Calculations of the contributions of secondary (2-step) reactions to these measured astatine yields were performed, based partially upon the observed sup(211)At activity although even at the highest energies, the contribution to products lighter than sup(207)At was negligible. These data for products with as many as 7 neutrons removed from the doubly coherent product (sup(210)At) display nearby gaussian shapes for the mass distributions of the astatine residues with the maximum occurring for about sup(204)At. The most probable momentum transfer deduced from these distributions for the initial πsup(-) production step was 335 MeV/c. The observed excitation functions display a behaviour similar to that observed for the yield of sup(210)Po from a (p,πsup(O)) reaction on sup(209)Bi, but radically different from that observed for inclusive πsup(-) reactions on a heavy nucleus. These data are discussed in terms of recent theoretical approaches to negative pion production from bismuth. In addition, a simple, schematic model is developed to treat the rapidly decreasing percentage of the total inclusive πsup(-) emission which is observed for this double charge exchange reaction. This model reflects the capacity of a nucleus to a source of internal energetic protons

  4. Human radiation studies: Remembering the early years: Oral history of Dr. Patricia Wallace Durbin, Ph.D., conducted November 11, 1994

    International Nuclear Information System (INIS)

    This report is a transcript of an interview of Dr. Patricia Wallace Durbin by representatives of the US DOE Office of Human Radiation Research. Dr. Durbin was selected for this interview because of her knowledge of the human plutonium injections and her recollections of key figures, especially Joseph Hamilton. After a brief biographical sketch Dr. Durbin discusses her loss of research funding from DOE, her recollections concerning research into strontium metabolism as part of Project Sunshine, her recollections relating to the rationale for studies of human metabolism of radionuclides, her remembrances of Dr. Hamilton's Astatine and Plutonium research, and her experiences in gathering archival records concerning these researches

  5. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    OpenAIRE

    BAYRAM, Ali

    1998-01-01

    In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 1...

  6. 绿花椰菜片剂中莱菔硫烷含量测定及对急性酒精性肝损伤的保护作用%Quantitative determination of sulforaphane from broccoli extract tablets and its role in the protection of acute liver injury induced by ethanol . Journal of Zhejiang University (Agric . & Life Sci .), 2013,39(2):197-202

    Institute of Scientific and Technical Information of China (English)

    李宝龙; 田思聪; 谭洁; 李冰; 陈镜羽; 单毓娟

    2013-01-01

    Summary Sulforaphane ( SFN) is an isothiocyanate ( ITC) which exists as a precursor of glucosinolate ( GS) in various cruciferous vegetables especially in broccoli . Sulforaphane has been regarded as a potential of anti‐cancer agent derived from diet , mostly because of its powerful induction of phase Ⅱ enzymes , and it is also acted as an antagonist of injury factors including lipopolysaccharide ( LPS) and homocysteine ( HCY) . The present study aims to explore whether broccoli extract , rich in sulforaphane , can protect the acute liver injury induced by ethanol in mice or not . The quantity of sulforaphane in broccoli extract was detected by high performance liquid chromatography ( HPLC) . Hematoxylin‐eosin ( HE) staining was used to determine the pathological changes in C 57BL/6 mice model with the acute liver injury induced by ethanol . The activities of alanine aminotransferase ( ALT) , aspartate aminotransferase ( AST) and alkaline phosphatase ( ALP) in serum of mice were measured using semi‐automatic biochemical analyzer . The results showed that the quantity of sulforaphane in the broccoli extract was 1 .26 mg/tablet . Liver masses in all sulforaphane treatment groups were obviously reduced which were presented as the sharply decreased ratio of liver mass/body mass . The seriously pathological evidence was observed in ethanol treatment group , while less changes were seen in the sulforaphane treatment groups . Sulforaphane could dramatically inhibit the activities of ALT , AST and ALP in serum of mice induced by ethanol , with more obvious suppression in the moderate ( 40 mg/kg) and high‐dose (80 mg/kg) groups , respectively . The result above indicates that the sulforaphane from broccoli extract tablets is able to protect the liver injury induced by ethanol .%  采用高效液相色谱法测定绿花椰菜水提物中莱菔硫烷的含量;以C57BL/6小鼠建立急性酒精性肝损伤模型,用苏木精‐伊红染色法( hematoxylin‐eosin staining , HE )检测莱菔硫烷对小鼠肝脏病理学的影响;采用半自动生化分析仪测定莱菔硫烷对肝脏丙氨酸氨基转移酶( alanine aminotransferase , ALT )、天门冬氨酸氨基转移酶( aspartate aminotransferase , AST)和碱性磷酸酶( alkaline phosphatase , ALP)活性的影响,以探讨绿花椰菜中的活性成分莱菔硫烷对急性酒精性肝损伤的保护作用畅结果表明:绿花椰菜水提物中莱菔硫烷的含量为1.26 mg/片;莱菔硫烷各剂量组均可明显降低酒精所致的肝质量增加,肝/体比值较酒精模型组明显下降( P<0.01);莱菔硫烷各剂量组均能减轻酒精对肝脏的病理学损伤,其中,高剂量莱菔硫烷组(80 mg/kg)的作用尤为明显;莱菔硫烷能明显抑制酒精对肝脏ALT、AST和ALP等特征性酶的诱导作用,其中40和80 mg/kg中、高剂量莱菔硫烷的保护作用更明显畅说明莱菔硫烷能保护酒精对肝脏的损伤.

  7. Nuclear isomer separation

    International Nuclear Information System (INIS)

    Pure specimens of nuclear isomers are required for gamma-ray lasers. The author has selectively photoionized atoms containing isomeric nuclei of 197Hg. The isomers were produced by the 197Au(d, 2n)197Hg reaction and distilled. Three pulsed dye lasers were used to selectively ionize mercury atoms by double resonant three-step photoionization. Other isomer separation techniques and their limitations are discussed. (author)

  8. Microscopic studies of radioactive Hg implanted in YBa$_{2}$Cu$_{3}$O$_{6+x}$ superconducting thin films

    CERN Document Server

    Amaral, V S; Lourenço, C; Marques, J G; Mendes, J A; Baptista, M A; Araújo, J P; Moreira, J M; Sousa, J B; Alves, E; Da Silva, M F A; Soares, J C

    1998-01-01

    YBa$_{2}$Cu$_{3}$O$_{6+x}$ (YBCO) superconducting thin films implanted with low doses of radioactive $^{197m}$Hg and $^{199m}$Hg isotopes were studied with a combination of nuclear and non-nuclear characterization techniques. We show that after implantation Hg lies on an unique site in the YBCO lattice and the critical temperature increases slightly with the increase of the $^{197}$Au concentration from the nuclear transmutation of $^{197}$Hg.

  9. Alpha-decay studies of the new isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At

    CERN Document Server

    Kettunen, H; Grahn, T; Greenlees, P T; Jones, P; Julin, R; Juutinen, S; Keenan, A; Kuusiniemi, P; Leino, M; Leppaenen, A P; Nieminen, P; Pakarinen, J; Rahkila, P; Uusitalo, J

    2003-01-01

    Detailed alpha-decay studies have been performed for the neutron-deficient isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At. The nuclei were produced in fusion-evaporation reactions of sup 5 sup 4 Fe and sup 5 sup 6 Fe ions with a sup 1 sup 4 sup 1 Pr target. The fusion products were separated in-flight using a gas-filled recoil separator and implanted into a position-sensitive silicon detector. The isotopes were identified using position, time and energy correlations between the implants and subsequent alpha-decays. Three alpha-decaying states were identified for sup 1 sup 9 sup 3 At and two for sup 1 sup 9 sup 1 At. The spin and parity of the initial states in the astatine isotopes were deduced based on unhindered alpha-decays to states in the bismuth daughter nuclei. In both astatine isotopes the 1/2 sup + intruder state was determined to be the ground state and a 7/2 sup - state to be the first-excited state. In sup 1 sup 9 sup 3 At the alpha-decay of the 13/2 sup + state was observed in coincidence...

  10. Rationalization of the solvation effects on the AtO+ ground-state change.

    Science.gov (United States)

    Ayed, Tahra; Réal, Florent; Montavon, Gilles; Galland, Nicolas

    2013-09-12

    (211)At radionuclide is of considerable interest as a radiotherapeutic agent for targeted alpha therapy in nuclear medicine, but major obstacles remain because the basic chemistry of astatine (At) is not well understood. The AtO(+) cationic form might be currently used for (211)At-labeling protocols in aqueous solution and has proved to readily react with inorganic/organic ligands. But AtO(+) reactivity must be hindered at first glance by spin restriction quantum rules: the ground state of the free cation has a dominant triplet character. Investigating AtO(+) clustered with an increasing number of water molecules and using various flavors of relativistic quantum methods, we found that AtO(+) adopts in solution a Kramers restricted closed-shell configuration resembling a scalar-relativistic singlet. The ground-state change was traced back to strong interactions, namely, attractive electrostatic interactions and charge transfer, with water molecules of the first solvation shell that lift up the degeneracy of the frontier π* molecular orbitals (MOs). This peculiarity brings an alternative explanation to the highly variable reproducibility reported for some astatine reactions: depending on the production protocols (with distillation in gas-phase or "wet chemistry" extraction), (211)At may or may not readily react. PMID:23944251

  11. EST Table: FS774145 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS774145 E_FL_fcaL_03N15_R_0 10/09/28 89 %/197 aa ref|NP_001036841.1| Annexin IX is...oform A [Bombyx mori] dbj|BAA92809.1| annexin IX-A [Bombyx mori] 10/09/08 71 %/197 aa FBpp0280989|DpseGA1909...1|gene:ANXB9 10/09/10 60 %/197 aa gnl|Amel|GB16448-PA 10/09/10 71 %/197 aa gi|91092420|ref|XP_967931.1| PREDICTED: similar to Annexin IX CG5730-PC [Tribolium castaneum] FS780436 fcaL ...

  12. AcEST: DK943635 [AcEST

    Lifescience Database Archive (English)

    Full Text Available r|Q9F5W3|Q9F5W3_BACCI Cyclodextrin glucanotransferase OS=Bacill... 44 0.007 tr|Q197W1|Q197W1_9BACI Beta-cyclodextrin...lodextrin glycosyltransferase OS=Bacillus sp. N-227 PE=3 SV=1 Length = 713 Score = ...PVNST-TVYIQW 422 G+N T P + T T+ + W Sbjct: 690 EGGANRTFTTPTSGTATMNVNW 711 >tr|Q197W1|Q197W1_9BACI Beta-cyc

  13. AcEST: BP912054 [AcEST

    Lifescience Database Archive (English)

    Full Text Available Q A + R + P++ LP D +AV+VMHKLM +LM +E+ V+++ AA Sbjct: 197 EKEQNA---ETTVKHRAAFAPHIDSLPADKMAVIVMHKLMGLLMMGGKEER...ILAVVVMHKLMAVLMK-EQEQGYVRLLNAAT 85 EQ A + R + P++ LP D +AV+VMHKLM +LM +E+ V+++ AA Sbjct: 196 EKEQNA---ETTVKHRAAFAPHID...+ V+++ AA Sbjct: 197 EKEQNA---ETTVKHRAAFAPHIDSLPADKMAVIVMHKLMGLLMMGGKEERCVQVVQAAV

  14. AcEST: BP914773 [AcEST

    Lifescience Database Archive (English)

    Full Text Available GPYLLQLPPDILAVVVMHKLMAVLMK-EQEQGYVRLLNAAT 87 EQ A + R + P++ LP D +AV+VMHKLM +LM +E+ V+++ AA Sbjct: 197 EKEQNA---ETTVKHRAAFAPHID...HKLM +LM +E+ V+++ AA Sbjct: 196 EKEQNA---ETTVKHRAAFAPHIDSLPADKMAVIVMHKLMGLLMMGGKE...RLLNAAT 87 EQ A + R + P++ LP D +AV+VMHKLM +LM +E+ V+++ AA Sbjct: 197 EKEQNA---ETTVKHRAAFAPHID

  15. Stability of excited nuclei in a dynamical simulation

    International Nuclear Information System (INIS)

    We investigate the stability of excited 197Au nuclei with respect to multifragmentation using a dynamical simulation based on molecular dynamics and restructured aggregation. We focus attention on 3 kinds of excitations: heat, compression and rotation. We also study the influence of a geometrical perturbation created when a projectile drills a hole in a 197Au nucleus

  16. Effect of 7-valent pneumococcal conjugate vaccine on nasopharyngeal carriage with Haemophilus influenzae and Moraxella catarrhalis in a randomized controlled trial

    NARCIS (Netherlands)

    van Gils, Elske J M; Veenhoven, Reinier H; Rodenburg, Gerwin D; Hak, Eelko; Sanders, Elisabeth A M

    2011-01-01

    Seven-valent CRM197-conjugated pneumococcal conjugate vaccine (PCV7(CRM197)) reduces both vaccine serotype nasopharyngeal colonization and vaccine serotype acute otitis media by 50-60%. However, overall pneumococcal carriage and impact on otitis media are partly offset by concomitant increase of non

  17. EST Table: CN211900 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CN211900 rzhswab0_002080 10/09/28 88 %/197 aa ref|NP_001093316.1| adiponectin recep...tor [Bombyx mori] gb|ABK57116.2| adiponectin receptor [Bombyx mori] 10/09/01 73 %/197 aa FBpp0151302|DgriGH1

  18. Aspects of productivity of mangroves

    Digital Repository Service at National Institute of Oceanography (India)

    Wafar, S.

    stream_size 3 stream_content_type text/plain stream_name Conserv_Mangrove_Forest_Genet_Resour_1994_197.pdf.txt stream_source_info Conserv_Mangrove_Forest_Genet_Resour_1994_197.pdf.txt Content-Encoding ISO-8859-1 Content-Type text...

  19. Drug: D00059 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00059 Drug Levodopa (JP16/USP/INN); Dopar (TN) C9H11NO4 197.0688 197.1879 D00059.gif Antiparkins...4728(1812+1813+1814+1815+1816) Dopaminergic synapse map07057 Antiparkinsonian age... 11 Agents affecting central nervous system 116 Antiparkinsonian agents 1164 Levodopas D00059 Levodopa (JP16

  20. Effect of increased CRM₁₉₇ carrier protein dose on meningococcal C bactericidal antibody response.

    Science.gov (United States)

    Lee, Lucia H; Blake, Milan S

    2012-04-01

    New multivalent CRM(197)-based conjugate vaccines are available for childhood immunization. Clinical studies were reviewed to assess meningococcal group C (MenC) antibody responses following MenC-CRM(197) coadministration with CRM(197)-based pneumococcal or Haemophilus influenzae type b conjugate vaccines. Infants receiving a total CRM(197) carrier protein dose of ∼50 μg and concomitant diphtheria-tetanus-acellular pertussis (DTaP)-containing vaccine tended to have lower MenC geometric mean antibody titers and continued to have low titers after the toddler dose. Nevertheless, at least 95% of children in the reported studies achieved a MenC serum bactericidal antibody (SBA) titer of ≥ 1:8 after the last infant or toddler dose. SBA was measured using an assay with a baby rabbit or human complement source. Additional studies are needed to assess long-term antibody persistence and MenC CRM(197) conjugate vaccine immunogenicity using alternative dosing schedules.

  1. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

    2013-01-01

    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  2. Development of 211At Chemistry for Labelling Biomolecules

    International Nuclear Information System (INIS)

    Our studies have demonstrated that high recovery of 211At can be obtained using a “wet chemistry” approach to isolation from the bismuth target. We have also demonstrated that direct labelling of antibody-B10 conjugates with 211At can be performed in high yields, and that the astatinated antibodies are stable to in vivo deastatination. While these results will allow us to enter clinical studies with 211At-labelled antibodies, the chemistry associated with 211At is not fully understood. Therefore, it is important that many more basic studies to be conducted with 211At, so the optimal labelling reagent for each type of disease-targeting agent becomes apparent

  3. Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status

    DEFF Research Database (Denmark)

    Lyckesvärd, Madeleine Nordén; Delle, Ulla; Kahu, Helena;

    2014-01-01

    Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ((211)At), concentrated in the thyroid by the same...... levels of γH2AX decreased during the first 24h in both cycling and stationary cultures and complete repair was seen in all cultures but cycling cells exposed to (211)At. Compared to stationary cells alpha particles were more harmful for cycling cultures, an effect also seen at the pChk2 levels...... cultures at a modest level of damage, clearly demonstrating that cell cycle status influences the relative effectiveness of alpha particles....

  4. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    Directory of Open Access Journals (Sweden)

    Ali BAYRAM

    1998-03-01

    Full Text Available In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 10, 50 and 259 mm/min. Strength properties of dual-phase steels were investigated depending on annealing temperature, ratio of martensite and loading rate.

  5. Antitumor effect of COOH-terminal polypeptide of human TERT is associated with the declined expression of hTERT and NF-κB p65 in HeLa cells.

    Science.gov (United States)

    Wu, Xian; Chen, Jiasheng; Cao, Ying; Xie, Baoping; Li, Hongwei; Zhou, Pingzheng; Qiu, Yuchang; Pang, Jianxin

    2015-12-01

    Human telomerase reverse transcriptase (hTERT) plays an important role in the development of tumors and has been investigated as a potent target for anticancer therapy. In the present study, we constructed a recombinant adenovirus, Ad-EGFP-C197 which was capable of expressing COOH‑terminal polypeptide of hTERT (amino acid 936-1,132, termed as C197 for the reason that it contains 197 amino acids). Infection of HeLa cells with Ad-EGFP-C197 suppressed the activity of telomerase, decreased the expression of hTERT and NF-κB p65, and induced rapid growth delay and apoptosis of HeLa cells in vitro. In nude mice xenografted with HeLa tumors, injection of Ad-EGFP-C197 into the tumor nodule significantly slowed tumor growth and promoted tumor cell apoptosis, as well as reduced the expression of NF-κB p65 in tumor tissues. In the present study, we suggest that the antitumor effect of C197 is associated with the declined expression of hTERT and NF-κB p65. Our results highlight the potential of C197 in tumor therapy.

  6. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: bruce.marsh@cern.ch [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others

    2013-12-15

    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  7. Tolerance to various toxicants by marine bacteria highly resistant to mercury

    Digital Repository Service at National Institute of Oceanography (India)

    De, J.; Ramaiah, N.; Mesquita, A.; Verlecar, X.N.

    Microbiol. Lett. 100: 197-204. Gerlach, A. S. (1981). Marine Pollution. Diagnosis and Therapy. pp. 218. Springer-Verlag Berlin Heidelberg New York. Hideomi N., Ishikawa, T., Yasunaga, S., Kondo, I., and Mitsuhasi, S. (1977). Frequency of heavy...

  8. 2010 U.S. Geological Survey (USGS) Topographic Lidar: Channel Islands, California

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Terrapoint collected LiDAR for 197 square miles covering five islands off the coast of Los Angeles, California. These islands are part of the Channel Islands...

  9. Activation cross-sections of deuteron induced nuclear reactions on gold up to 40 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Tarkanyi, F. [Institute of Nuclear Research of the Hungarian Academy of Sciences (ATOMKI), Debrecen (Hungary); Ditroi, F., E-mail: ditroi@atomki.hu [Institute of Nuclear Research of the Hungarian Academy of Sciences (ATOMKI), Debrecen (Hungary); Hermanne, A. [Cyclotron Laboratory, Vrije Universiteit Brussel (VUB), Brussels (Belgium); Takacs, S.; Kiraly, B. [Institute of Nuclear Research of the Hungarian Academy of Sciences (ATOMKI), Debrecen (Hungary); Yamazaki, H.; Baba, M.; Mohammadi, A. [Cyclotron and Radioisotope Center (CYRIC), Tohoku University, Sendai (Japan); Ignatyuk, A.V. [Institute of Physics and Power Engineering (IPPE), Obninsk (Russian Federation)

    2011-06-15

    Cross-sections of deuteron induced nuclear reactions on gold were measured up to 40 MeV by using the standard stacked foil irradiation technique and high resolution gamma-ray spectroscopy. Experimental cross-sections and derived integral yields are reported for the {sup 197}Au(d,xn){sup 197m,197g,195m,195g}Hg and {sup 197}Au(d,x){sup 198g,196m,196g,195,194}Au nuclear reactions. The experimental data are analyzed and compared to literature and predictions of the ALICE-IPPE, EMPIRE and TALYS theoretical model codes. The application of the new cross-sections for accelerator technology, medical radioisotope production, thin layer activation and dose calculation is discussed.

  10. Two Protons Emissions From 17Ne Excited States

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>The experiment 17Ne+197Au has been finished in Heavy Ion Research Facility Radioactive Ion Beam Line at Lanzhou (RIBLL). Through the total kinematic method of silicon strip detectors and CsI(Tl)+PIN

  11. ÉCRITURE FÉMININE: Reconstructing Social Identity and Recontextualizing the Scripture

    Directory of Open Access Journals (Sweden)

    M. Hanafi

    2010-12-01

    Full Text Available Book Review:Book title:Women, Islam and Everyday Life: Renegotiating Polygamy in Indonesia Author:Nina NurmilaNo. of Pages:xvii + 197Year:2010Publisher:Routledge, London and New York

  12. A comparison of biologically active elements in geese in relation to avian cholera

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Avian cholera caused an estimated mortality of between 166,000 to 197,000 migrating waterfowl in the Rainwater Basin of Nebraska in the 10-year period 1975 through...

  13. Complications of the post-chemotherapy resection of retroperitoneal residual tumour mass in patients with non-seminomatous testicular germ cell tumours

    NARCIS (Netherlands)

    Gels, ME; Nijboer, AP; Hoekstra, HJ; Sleijfer, DT; Molenaar, WM; Plukker, JT; Droste, JHJ; Schraffordt Koops, H.

    1997-01-01

    Objective To evaluate the resection of the retroperitoneal residual tumour mass (RRTM) for histological examination after chemotherapy in patients with disseminated non-seminomatous testicular germ cell tumours (NSTGCTs), with particular attention to surgical morbidity. Patients and methods From 197

  14. BIRD COMMUNITIES AND HABITAT AS ECOLOGICAL INDICATORS OF FOREST CONDITION IN REGIONAL MONITORING

    Science.gov (United States)

    Ecological indicators for long-term monitoring programs are needed to detect and assess changing environmental conditions, We developed and tested community-level environmental indicators for monitoring forest bird populations and associated habitat. We surveyed 197 sampling plo...

  15. Gclust Server: 174803 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 174803 CRE_182226=NUOP3 Cluster Sequences - 197 NADH:ubiquinone oxidoreductase (Com...ID 174803 Sequence ID CRE_182226=NUOP3 Link to cluster sequences Cluster Sequences Link to related sequences

  16. 76 FR 78284 - Pediatric Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2011-12-16

    ... Conjugate Vaccine (Diphtheria CRM197 Protein), Cervarix (Human Papillomavirus Bivalent (Types 16 and 18) vaccine, recombinant, Focalin XR (dexmethylphenidate), Daytrana (methylphenidate), Seroquel (quetiapine... accommodate persons with physical disabilities or special needs. If you require special accommodations due...

  17. 2. The Data Librarian: introducing the Data Librarian

    OpenAIRE

    Liscouski, Joe

    1997-01-01

    This paper provides some initial considerations into the design and function of the Data Librarian. The first part (Liscouski, J., 1997, Journal of Automatic Chemistry, 19, 193-197) described the need for the Librarian.

  18. Using Emotional Intelligence in Personalized Adaptation

    NARCIS (Netherlands)

    Damjanovic, Violeta; Kravcik, Milos

    2008-01-01

    Damjanovic, V. & Kravcik, M. (2007). Using Emotional Intelligence in Personalized Adaptation. In M. D. Lytras & A. Naeve (Eds.), Ubiquitous and Pervasive Knowledge and Learning Management (pp. 158-197). IGI Publishing.

  19. Pedagogical Implications of Contrastive Studies

    Science.gov (United States)

    Marton, Waldemar

    1972-01-01

    Pessimism regarding pedagogical applications of contrastive studies, and reasons therefore, are described. Several misunderstandings believed to contribute to this pessimism, and several areas of controversy concerning uses of contrastive studies, are discussed. See FL 508 197 for availability. (RM)

  20. Measurement of neutron-induced activation cross-sections using spallation source at JINR and neutronic validation of the Dubna code

    Indian Academy of Sciences (India)

    Manish Sharma; V Kumar; H Kumawat; J Adam; V S Barashenkov; S Ganesan; S Golovatiouk; S K Gupta; S Kailas; M I Krivopustov; H S Palsania; V Pronskikh; V M Tsoupko-Sitnikov; N Vladimirova; H Westmeier; W Westmeier

    2007-02-01

    A beam of 1 GeV proton coming from Dubna Nuclotron colliding with a lead target surrounded by 6 cm paraffin produces spallation neutrons. A Th-foil was kept on lead target (neutron spallation source) in a direct stream of neutrons for activation and other samples of 197Au, 209Bi, 59Co, 115In and 181Ta were irradiated by moderated beam of neutrons passing through 6 cm paraffin moderator. The gamma spectra of irradiated samples were analyzed using gamma spectrometry and DEIMOS software to measure the neutron cross-section. For this purpose neutron fluence at the positions of samples is also estimated using PREPRO software. The results of cross-sections for reactions 232Th(, ), 232Th(, 2), 197Au(, ), 197Au(, ), 197Au(, ), 59Co(, ), 59Co(, ), 181Ta(, ) and 181Ta(, ) are given in this paper. Neutronics validation of the Dubna Cascade Code is also done using cross-section data by other experiments.

  1. Influence of IL17A polymorphisms on the aberrant methylation of DAPK and CDH1 in non-cancerous gastric mucosa

    Directory of Open Access Journals (Sweden)

    Arisawa Tomiyasu

    2012-07-01

    Full Text Available Abstract Background CpG island aberrant methylation is shown to be an important mechanism in gene silencing. The important role of IL-17 in inflammatory response to H. pylori colonization has been indicated. We investigated the influence of IL17A polymorphisms, -197 G > A (rs2275913 and *1249 C > T (rs3748067, on the methylation of DAPK and CDH1. Methods Gastric mucosal samples were obtained from 401 subjects without malignancies. Methylation status of gene was determined by MSP. The genotyping of IL17A was performed by PCR-SSCP. Results Methylations of DAPK and CDH1 were seen in 196 and 149 of all 401 subjects, respectively. Overall, *1249 T carrier was associated with a decreased risk for DAPK methylation, whereas -197 G > A was not. In the subjects older than 60 years old, *1249 T carrier was more strongly associated with gene methylation and -197 A carrier tended to be associated with an increased risk for CDH1 methylation. When evaluating by inflammation promoting haplotype (-197 mutant carrier with *1249 homozygote, this haplotype had a more strongly increased risk for both DAPK and CDH1 methylations in comparatively older subjects. Both atrophy and metaplasia scores were significantly increased with age in -197 A carrier or *1249 CC homozygote, whereas were not in -197 GG homozygote or *1249 T carrier. PG I/II ratio was more significantly decreased in -197 A carrier than in GG homozygote under influence of H. pylori infection. Conclusions In -197 A allele carrier with *1249 CC homozygote, the methylations of both DAPK and CDH1 may be increased gradually, but more rapidly than the other genotypes, with age and altered gastric mucosal structure induced by H. pylori infection.

  2. AcEST: DK961409 [AcEST

    Lifescience Database Archive (English)

    Full Text Available lodextrin glycosyltransferase OS=... 45 0.003 tr|B2AYY9|B2AYY9_PODAN Predicted CDS ...enophora tri... 46 0.002 tr|Q9F5W3|Q9F5W3_BACCI Cyclodextrin glucanotransferase OS=Bacill... 45 0.003 tr|Q197W1|Q197W1_9BACI Beta-cyc

  3. NCBI nr-aa BLAST: CBRC-OCUN-01-0782 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OCUN-01-0782 ref|YP_797515.1| Prolipoprotein diacylglyceryltransferase [Leptospira borgpeter...senii serovar Hardjo-bovis L550] ref|YP_801264.1| Prolipoprotein diacylglyceryltransferase [Leptospira borgpeter...senii serovar Hardjo-bovis JB197] gb|ABJ78582.1| Prolipoprotein diacylglyceryltransferase [Leptospira borgpeter...in diacylglyceryltransferase [Leptospira borgpetersenii serovar Hardjo-bovis JB197] YP_797515.1 3.3 35% ...

  4. Investigation of nuclear multifragmentation using molecular dynamics and restructured aggregation

    International Nuclear Information System (INIS)

    We study the stability of excited 197 Au nuclei with respect to multifragmentation. For that we use a dynamical simulation based on molecular dynamics and restructured aggregation. A particular attention is paid to check the stability of the ground state nuclei generated by the simulation. Four kinds of excitations are considered: heat, compression, rotation and a geometrical instability created when a projectile drills a hole in a 197 Au nucleus

  5. Disassembly of hot nuclear matter formed in Au-induced reactions near the Fermi energy

    Energy Technology Data Exchange (ETDEWEB)

    Delis, D.N.

    1993-09-01

    Complex fragment emission has been studied in the 60 MeV/A {sup 197}Au + {sup 12}C, {sup 27}Al, {sup 51}V, {sup nat}Cu, and {sup 197}Au reactions. Velocity spectra, angular distributions and cross sections have been constructed for each target from the inclusive data. Coincidence data including 2-, 3-, 4-, and 5-fold events have also been examined. Furthermore neutron multiplicity distributions have been obtained for the above reactions by utilizing a novel neutron calorimetric approach.

  6. The Influence of Immunization Route, Tissue Microenvironment, and Cytokine Cell Milieu on HIV-Specific CD8+ T Cells Measured Using Fluidigm Dynamic Arrays

    OpenAIRE

    Trivedi, Shubhanshi; Ranasinghe, Charani

    2015-01-01

    Thirty different genes including cytokines, chemokines, granzymes, perforin and specifically integrins were evaluated in Peyer's patch-KdGag197–205-specific CD8+ T cells (pools of 100 cells) using Fluidigm 48.48 Dynamic arrays following three different prime-boost immunization strategies. Data revealed that the route of prime or the booster immunization differentially influenced the integrin expression profile on gut KdGag197–205-specific CD8+ T cells. Specifically, elevated numbers of integr...

  7. Target fragmentation at intermediate energies

    International Nuclear Information System (INIS)

    We report the results of measurements of the average target fragment momenta and energies in the interaction of 12.0 and 18.4 MeV/u 160, and 45.4 and 83.8 MeV/u 12C with 197Au. We compare these data with previously published studies of the interaction of 380 MeV/u 20Ne and 400 and 2100 MeV/u 12C with 197Au

  8. A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation.

    Directory of Open Access Journals (Sweden)

    J Luis Espinoza

    Full Text Available Interleukin IL-17 is a proinflammatory cytokine that has been implicated in the pathogenesis of various autoimmune diseases. The single nucleotide polymorphism (SNP, rs2275913, in the promoter region of the IL-17 gene is associated with susceptibility to ulcerative colitis. When we examined the impact of rs2275913 in a cohort consisting of 438 pairs of patients and their unrelated donors transplanted through the Japan Marrow Donor Program, the donor IL-17 197A allele was found to be associated with a higher risk of acute graft-versus-host disease (GVHD; hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.00 to 2.13; P = 0.05. Next, we investigated the functional relevance of the rs2275913 SNP. In vitro stimulated T cells from healthy individuals possessing the 197A allele produced significantly more IL-17 than those without the 197A allele. In a gene reporter assay, the 197A allele construct induced higher luciferase activity than the 197G allele, and the difference was higher in the presence of T cell receptor activation and was abrogated by cyclosporine treatment. Moreover, the 197A allele displayed a higher affinity for the nuclear factor activated T cells (NFAT, a critical transcription factor involved in IL-17 regulation. These findings substantiate the functional relevance of the rs2275913 polymorphism and indicate that the higher IL-17 secretion by individuals with the 197A allele likely accounts for their increased risk for acute GVHD and certain autoimmune diseases.

  9. Improving the neutral phytase activity from Bacillus amyloliquefaciens DSM 1061 by site-directed mutagenesis.

    Science.gov (United States)

    Xu, Wei; Shao, Rong; Wang, Zupeng; Yan, Xiuhua

    2015-03-01

    Neutral phytase is used as a feed additive for degradation of anti-nutritional phytate in aquatic feed industry. Site-directed mutagenesis of Bacillus amyloliquefaciens DSM 1061 phytase was performed with an aim to increase its activity. Mutation residues were chosen based on multiple sequence alignments and structure analysis of neutral phytsaes from different microorganisms. The mutation sites on surface (D148E, S197E and N156E) and around the active site (D52E) of phytase were selected. Analysis of the phytase variants showed that the specific activities of mutants D148E and S197E remarkably increased by about 35 and 13% over a temperature range of 40-75 °C at pH 7.0, respectively. The k cat of mutants D148E and S197E were 1.50 and 1.25 times than that of the wild-type phytase, respectively. Both D148E and S197E showed much higher thermostability than that of the wild-type phytase. However, mutants N156E and D52E led to significant loss of specific activity of the enzyme. Structural analysis revealed that these mutations may affect conformation of the active site of phytase. The present mutant phytases D148E and S197E with increased activities and thermostabilities have application potential as additives in aquaculture feed. PMID:25613522

  10. Thermal-neutron cross sections and resonance integrals of 138Ba and 141Pr using Am-Be neutron source

    Science.gov (United States)

    Panikkath, Priyada; Mohanakrishnan, P.

    2016-09-01

    The thermal-neutron capture cross sections and resonance integrals of 138Ba(n, γ)139Ba and 141Pr(n, γ)142Pr were measured by activation method using an isotopic Am-Be neutron source. The estimations were with respect to that of 55Mn(n, γ)56Mn and 197Au(n, γ)198Au reference monitors. The measured thermal-capture cross section of 138 Ba with respect to 55 Mn is 0.410±0.023 b and with respect to 197 Au is 0.386±0.019 b. The measured thermal-capture cross section of 141 Pr with respect to 55 Mn is 11.36±1.29 b and with respect to 197 Au is 10.43±1.14 b. The resonance integrals for 138 Ba are 0.380±0.033 b (55 Mn) and 0.364±0.027 b (197 Au) and for 141 Pr are 21.05±2.88 b (55 Mn) and 15.27±1.87 b (197 Au). The comparison between the present measurements and various reported values are discussed. The cross sections corresponding to the selected isotopes are measured using an Am-Be source facility for the first time.

  11. Expression and significance of heparin binding-epidermal growth factor-like growth factor in paclitaxel-resistant ovarian cancer%肝素结合表皮生长因子在紫杉醇耐药卵巢上皮性癌细胞和组织中的表达及意义

    Institute of Scientific and Technical Information of China (English)

    汤小晗; 卢美松; 李翠萍; 邓锁; 李萌

    2014-01-01

    目的:检测肝素结合表皮生长因子(HB-EGF)在紫杉醇耐药卵巢上皮性癌(卵巢癌)细胞和组织中的表达水平,并探讨HB-EGF与卵巢癌紫杉醇耐药性的关系。方法(1)体外实验:蛋白印迹法检测卵巢癌细胞株A2780(紫杉醇敏感)和A2780/Taxol(紫杉醇耐药)细胞中HB-EGF蛋白的表达。体外细胞实验分为4组,A2780+CRM197组、A2780/Taxol+CRM197组、A2780组、A2780/Taxol组,采用四甲基偶氮唑蓝(MTT)比色法检测4组细胞的增殖能力[以吸光度(A)值表示],流式细胞仪检测4组细胞的细胞周期比例,酶标仪检测4组细胞中半胱氨酸天冬氨酸蛋白酶3(caspase-3)蛋白的活性[以4硝基苯胺(pNa)浓度表示]。(2)体内实验:将A2780和A2780/Taxol细胞分别接种于裸鼠腋下,建立卵巢癌裸鼠移植瘤模型;免疫组化SP法检测裸鼠移植瘤组织中HB-EGF蛋白的表达。体内动物实验分为4组,方法同体外细胞实验分组,每组5只裸鼠,观察4组裸鼠移植瘤的生长情况,并计算抑瘤率。结果(1)体外实验结果:A2780/Taxol细胞中HB-EGF蛋白的表达水平为2.11±0.41,明显高于A2780细胞的0.75±0.20(P<0.01)。A2780+CRM197组、A2780/Taxol+CRM197组细胞增殖的抑制作用随CRM197浓度的增加而增强,呈明显的浓度依赖性(P<0.01),且当CRM197浓度≥1μg/ml时,A2780/Taxol+CRM197组细胞增殖的抑制作用明显高于A2780+CRM197组细胞(P<0.05);A2780+CRM197组细胞G0/G1期比例[(67±4)%]高于A2780组[(54±6)%],A2780/Taxol+CRM197组细胞G0/G1期比例[(72±4)%]高于A2780/Taxol组[(24±8)%],分别比较,差异均有统计学意义(P<0.01);A2780+CRM197组细胞中pNa浓度[(40±6)μmol/L,即caspase-3蛋白活性]高于A2780组[(6±6)μmol/L],A2780/Taxol+CRM197组细胞中pNa浓度[(66±12)μmol/L]高于A2780/Taxol组[(9±6)μmol/L],分别比较,差

  12. Study of some properties of bound levels and virtual levels excited with resonance neutrons

    International Nuclear Information System (INIS)

    Many neutron resonance parameters of some nuclei with a spin value I 3/2 (35Cl, 37Cl, 63Cu, 65Cu, 197Au) are determined to find the strength function S0 with accuracy. For those nuclei, the S0 value seems not to depend on the spin value J=1 or 2 but could be depend on neutron energy for 197Au. Total radiative width variation against mass number A and spacing distributions between resonances (for 197Au) are studied and discussed. Analysis methods of neutron capture experiments are described in detail and level schemes of Cl, Mn, Fe, Co, Cu, Tm, Hg are presented sometimes with the spin value. Intensities of E1 and M1 transitions with direct capture and interference effects are discussed in view of experimental results. (author)

  13. Rab11-FIP1A regulates early trafficking into the recycling endosomes.

    Science.gov (United States)

    Schafer, Jenny C; McRae, Rebecca E; Manning, Elizabeth H; Lapierre, Lynne A; Goldenring, James R

    2016-01-15

    The Rab11 family of small GTPases, along with the Rab11-family interacting proteins (Rab11-FIPs), are critical regulators of intracellular vesicle trafficking and recycling. We have identified a point mutation of Threonine-197 site to an Alanine in Rab11-FIP1A, which causes a dramatic dominant negative phenotype when expressed in HeLa cells. The normally perinuclear distribution of GFP-Rab11-FIP1A was condensed into a membranous cisternum with almost no GFP-Rab11-FIP1A(T197A) remaining outside of this central locus. Also, this condensed GFP-FIP1A(T197A) altered the distribution of proteins in the Rab11a recycling pathway including endogenous Rab11a, Rab11-FIP1C, and transferrin receptor (CD71). Furthermore, this condensed GFP-FIP1A(T197A)-containing structure exhibited little movement in live HeLa cells. Expression of GFP-FIP1A(T197A) caused a strong blockade of transferrin recycling. Treatment of cells expressing GFP-FIP1A(T197A) with nocodazole did not disperse the Rab11a-containing recycling system. We also found that Rab5 and EEA1 were accumulated in membranes by GFP-Rab11-FIP1A but Rab4 was unaffected, suggesting that a direct pathway may exist from early endosomes into the Rab11a-containing recycling system. Our study of a potent inhibitory trafficking mutation in Rab11-FIP1A shows that Rab11-FIP1A associates with and regulates trafficking at an early step in the process of membrane recycling.

  14. The B-cell response to a primary and booster course of MenACWY-CRM₁₉₇ vaccine administered at 2, 4 and 12 months of age.

    Science.gov (United States)

    Blanchard-Rohner, Geraldine; Snape, Matthew D; Kelly, Dominic F; O'Connor, Daniel; John, Tessa; Clutterbuck, Elizabeth A; Ohene-Kena, Brigitte; Klinger, Chaam L; Odrljin, Tatjana; Pollard, Andrew J

    2013-05-01

    A quadrivalent meningococcal vaccine conjugated to CRM197 (MenACWY-CRM197) is immunogenic in young infants. We assessed the memory B-cell and antibody responses after a primary and booster course of MenACWY-CRM197 in children. At 5 months of age, following primary immunisation, serogroup-specific memory B-cells were detectable in fewer than 25% of children, although protective antibody titres (hSBA ≥ 4) were detectable in 69% of children against serogroup A and more than 95% against the other serogroups. At 12 months, before booster immunisation the percentages with hSBA ≥ 4 were 5% for serogroup A, and between 44 and 70% for the other serogroups. One month after booster immunisation with MenACWY-CRM197 over 50% of children had detectable memory B-cells, and 91% had hSBA ≥ 4 against serogroup A and more than 99% against the other serogroups. These data show that few antigen-specific anticapsular memory B-cells can be detected after two-doses priming with MenACWY-CRM197. For MenC and CRM197, the antigens with the highest number of B-cells at 5 months, there was a definite (p ≤0 .02) but weak correlation with antibody persistence at 12 months. Although previous studies suggest that measuring memory B-cell responses after priming immunisations in infancy can be used to predict antibody persistence and memory responses, this may not be suitable for all antigens in young children.

  15. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  16. The biokinetics of alpha-particle emitting radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, D.M. [School of Chemistry, Cardiff Univ., Cardiff (United Kingdom); Duffield, J.R. [Faculty of Applied Sciences, Univ. of the West of England, Bristol (United Kingdom)

    2005-07-01

    The past two decades have seen wide interest in the application of alpha-particle emitting radionuclides for targeted endoradiotherapy and a large number of compounds labeled with {sup 211}At (T{sup 1}/{sub 2} 7.21 h), {sup 212}Bi (T{sup 1}/{sub 2} 1 h) or {sup 213}Bi (T{sup 1}/{sub 2} 0.78 h) have been studied. Knowledge of the biokinetic behaviour of such agents is important both for their optimal clinical exploitation and for general radiological protection purposes. Animal studies of the distribution and retention of {sup 211}At compounds, including ionic astatide, substituted aromatic compounds and labelled monoclonal antibodies, have provided new information on the biochemistry of astatine. With respect the thyroid gland the uptake of the astatide ion has been shown to be very much lower than that of the iodide ion. Less information is available for {sup 212}Bi-labelled radiopharmaceuticals. The available data for both {sup 211}At and {sup 212}Bi radiopharmaceuticals are reviewed. Cautious generic biokinetic models for inorganic and simple organic compounds of {sup 211}At and {sup 212}Bi; for [{sup 211}At]-, and [{sup 212}Bi]-biphosphonates and for [{sup 211}At]-, and [{sup 212}Bi]-monoclonal antibodies, are proposed for use in general radiological protection when compound-specific data are not available. (orig.)

  17. Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with {sup 211}At-EGF

    Energy Technology Data Exchange (ETDEWEB)

    Sundberg, Aasa Liljegren; Orlova, Anna; Gedda, Lars; Tolmachev, Vladimir; Carlsson, Joergen [Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala (Sweden); Almqvist, Ylva [Division of Radiology, Uppsala University, Uppsala (Sweden); Blomquist, Erik [Division of Oncology, Uppsala University, Uppsala (Sweden); Jensen, Holger J. [Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Rigshospitalet, Copenhagen (Denmark)

    2003-10-01

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib ['Iressa' (trademark of the AstraZeneca group of companies), ZD1839] increases the cellular uptake of radiolabelled epidermal growth factor (EGF). We investigated gefitinib treatment combined with astatine-211 EGF targeting in vitro using two cell lines expressing high levels of EGFR: A431 (sensitive to gefitinib) and U343MGaCl2:1 (resistant to gefitinib). In both cell lines, the uptake of {sup 211}At-EGF was markedly increased by concomitant treatment with gefitinib. Survival was investigated using both a clonogenic survival assay and a cell growth assay. Combined gefitinib and {sup 211}At-EGF treatment reduced the survival of U343 cells 3.5-fold compared with {sup 211}At-EGF alone. In A431 cells, {sup 211}At-EGF treatment resulted in very low survival, but combined treatment with gefitinib increased the survival by about 20-fold. These results indicate that combined treatment with gefitinib might increase the effect of ligand-mediated radionuclide therapy in gefitinib-resistant tumours and decrease the effect of such therapy in gefitinib-sensitive tumours. (orig.)

  18. Alpha particle emitters in medicine

    International Nuclear Information System (INIS)

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 (211At) and natural bismuth-212 (212Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 (223Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs

  19. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  20. Development of Reagents for Application of At-211 to Targeted Radionuclide Therapy of Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott

    2011-12-23

    This grant covered only a period of 4 months as the major portion of the award was returned to DOE due to an award of funding from NIH that covered the same research objectives. A letter regarding the termination of the research is attached as the last page of the Final Report. The research conducted was limited due to the short period of this grant, but the results obtained in that period are outlined in the Final Report. The studies addressed in the research effort were directed at a problem that is of critical importance to the in vivo application of the alpha-particle emitting radionuclide At-211. That problem, low in vivo stability of many astatinated molecules, severely limits the use of At-211 in therapeutic applications. The advances sought in the studies were expected to expand the types of biomolecules that can be used as carriers of At-211, and provide improved in vivo targeting of the radiation dose compared with the dose delivered to normal tissue.

  1. Tumor immunotargeting using innovative radionuclides.

    Science.gov (United States)

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  2. SPECT assay of radiolabeled monoclonal antibodies. Progress report, September 1, 1992--August 24, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1993-08-20

    The overall goal of this project is to improve the effectiveness of single photon emission computed tomography (SPECT) to image and quantify radiolabeled monoclonal antibodies. During the past year, we have made significant progress toward this goal, and this report summarizes that work. Our efforts have been mainly directed along three fronts. First, we have developed and tested new reconstruction methods including three-dimensional iterative algorithms that model non-uniform attenuation and distance-dependent detector response. Both fan beam and parallel beam collimator geometries have been modeled and novel ways of improving the efficiency of the computationally intensive methods have been introduced. Second, an ultra-high resolution, small field-of-view pinhole collimator has been constructed and evaluated. Reconstructed spatial resolution of 1 to 3 mm (FWHM) has been achieved in phantom scans with a useful field-of-view of 9 to 10 cm. Finally, we have investigated the ability of SPECT to image and quantify astatine-211 distributions. Reconstructed images of phantom data demonstrated quantitative accuracy to within 10% with proper attenuation and scatter compensation.

  3. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  4. Nuclear and chemical data for life sciences

    International Nuclear Information System (INIS)

    Use of reactor produced radionuclides is popular in life sciences. However, cyclotron production of proton rich radionuclides are being more focused in recent times. These radionuclides have already gained attention in various fields, including life sciences, provided they are obtained in pure form. This article is a representative brief of our contributions in generating nuclear data for the production of proton rich radionuclides of terbium, astatine, technetium, ruthenium, cadmium, niobium, zirconium, rhenium, etc., which may have application in clinical, biological, agriculture studies or in basic research. The chemical data required to separate the product isotopes from the corresponding target matrix have been presented along with a few propositions of radiopharmaceuticals. It also emphasizes on the development of simple empirical technique, based on the nuclear reaction model analysis, to generate reliable nuclear data for the estimation of yield and angular distribution of emitted neutrons and light charged particles from light as well as heavy ion induced reactions on thick stopping targets. These data bear utmost important in radiation dosimetry. (author)

  5. Studies of Stable Octupole Deformations in the Radium Region

    CERN Multimedia

    2002-01-01

    The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

  6. Alpha particle emitters in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, D.R.

    1989-09-01

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ({sup 211}At) and natural bismuth-212 ({sup 212}Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ({sup 223}Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

  7. Effect of the density dependent symmetry energy on fragmentation

    CERN Document Server

    Vinayak, Karan Singh

    2011-01-01

    The effect of the density dependence of symmetry energy on fragmentation is studied using isospin-dependent quantum molecular dynamics model(IQMD) Model. We have used the reduced isospin-dependent cross-section with soft equation of state to explain the experimental findings for the system 79_Au^197 + 79_Au^197 for the full colliding geometry. In addition to that we have tried to study the collective response of the momentum dependent interactions(MDI) and symmetry energy towards the multifragmentation

  8. Pseudoexfoliation syndrome and secondary cataract

    OpenAIRE

    Kuchle, M.; A. Amberg; Martus, P.; Nguyen, N.; NAUMANN, G.

    1997-01-01

    AIM/BACKGROUND—The pseudoexfoliation (PEX) syndrome is frequently associated with impairment of the blood-aqueous barrier. This study analysed if this might stimulate secondary cataract following cataract extraction.
METHODS—This historical cohort study included 197 eyes of 197 patients (99 with and 98 without PEX) that underwent extracapsular cataract extraction with posterior chamber lens implantation (PMMA optic) between 1985 and 1991. Secondary cataract was defined as opacification of the...

  9. ENDF/B-5 Standards Data Library (including modifications made in 1986). Summary of contents and documentation

    International Nuclear Information System (INIS)

    This document summarizes the contents and documentation of the ENDF/B-5 Standards Data Library (EN5-ST) released in September 1979. The library contains complete evaluations for all significant neutron reactions in the energy range 10-5eV to 20 MeV for H-1, He-3, Li-6, B-10, C-12, Au-197 and U-235 isotopes. In 1986 the files for C-12, Au-197 and U-235 were slightly modified. The entire library or selective retrievals from it can be obtained free of charge from the IAEA Nuclear Data Section. (author)

  10. Passive neutron dosemeter with activation detector

    Energy Technology Data Exchange (ETDEWEB)

    Valero L, C.; Banuelos F, A.; Guzman G, K. A.; Borja H, C. G.; Hernandez D, V. M.; Vega C, H. R., E-mail: fermineutron@yahoo.com [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Calle Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)

    2011-10-15

    A passive neutron dosemeter with {sup 197}Au activation detector has been developed. The area dosemeter was made as a 20.5 {phi} x 20.5 cm{sup 2} polyethylene moderator, with a polyethylene pug where a {sup 197}Au foil can be located either parallel or perpendicular to moderator axis. Using Monte Carlo methods, with the MCNP5 code. With the fluence response and the fluence-to-equivalent dose conversion coefficients from ICRP-74, responses to H*(10) were also calculated, these were compared against responses of commercially available neutron area monitors and dosemeters. (Author)

  11. NCBI nr-aa BLAST: CBRC-OCUN-01-1280 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OCUN-01-1280 ref|YP_798310.1| hypothetical protein LBL_1947 [Leptospira borgpeter...senii serovar Hardjo-bovis L550] ref|YP_801037.1| hypothetical protein LBJ_1728 [Leptospira borgpeterseni...i serovar Hardjo-bovis JB197] gb|ABJ79377.1| Conserved hypothetical protein [Leptospira borgpetersenii serov...ar Hardjo-bovis L550] gb|ABJ76279.1| Conserved hypothetical protein [Leptospira borgpetersenii serovar Hardjo-bovis JB197] YP_798310.1 4.1 31% ...

  12. NCBI nr-aa BLAST: CBRC-HSAP-07-0021 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-HSAP-07-0021 ref|YP_798483.1| hypothetical protein LBL_2137 [Leptospira borgpeter...senii serovar Hardjo-bovis L550] ref|YP_801392.1| hypothetical protein LBJ_2143 [Leptospira borgpeterseni...i serovar Hardjo-bovis JB197] gb|ABJ79550.1| Conserved hypothetical protein [Leptospira borgpetersenii serov...ar Hardjo-bovis L550] gb|ABJ76634.1| Conserved hypothetical protein [Leptospira borgpetersenii serovar Hardjo-bovis JB197] YP_798483.1 0.026 28% ...

  13. NCBI nr-aa BLAST: CBRC-TSYR-01-0989 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TSYR-01-0989 ref|YP_796828.1| hypothetical protein LBL_0283 [Leptospira borgpeter...senii serovar Hardjo-bovis L550] ref|YP_801953.1| hypothetical protein LBJ_2788 [Leptospira borgpeterseni...i serovar Hardjo-bovis JB197] gb|ABJ77895.1| Hypothetical protein LBL_0283 [Leptospira borgpetersenii serova...r Hardjo-bovis L550] gb|ABJ77195.1| Hypothetical protein LBJ_2788 [Leptospira borgpetersenii serovar Hardjo-bovis JB197] YP_796828.1 4.4 38% ...

  14. Formation of fragments in heavy-ion collisions using modified clusterization method

    CERN Document Server

    Goyal, Supriya

    2011-01-01

    We study the formation of fragments by extending the minimum spanning tree method (MST) for clusterization. In this extension, each fragment is subjected to a binding-energy check calculated using the modified Bethe-Weizsacker formula. Earlier, a constant binding-energy cut of 4 MeV/nucleon was imposed. Our results for 197Au +197 Au collisions are compared with ALADiN data and also with the calculations based on the simulated annealing technique. We shall show that the present modified version improves the agreement compared to the MST method.

  15. Status of the experiment ASYEOS

    Energy Technology Data Exchange (ETDEWEB)

    Kupny, Sebastian [GSI Helmholtzzentrum GmbH Darmstadt (Germany); Collaboration: ASYEOS-Collaboration

    2012-07-01

    Neutron-proton squeeze-out is predicted to provide quantitative information on the symmetry term of the nuclear Equation of State at supra-saturation densities. Hence we designed an experiment consisting out of the CHIMERA charged particle detector for impact parameter determination and reaction plane reconstruction, the LAND neutron detector to measure neutron and proton squeeze-out and a Triple Telescope Array to identify light fragments. Measurements of 197Au+197Au, 96Ru+96Ru and 96Zr+96Zr collisions at 400 A MeV have been accomplished in May 2011 at the GSI facility. Current status of the analysis, first results and future plans are presented.

  16. Photovoltage versus microprobe sheet resistance measurements on ultrashallow structures

    DEFF Research Database (Denmark)

    Clarysse, T.; Moussa, A.; Parmentier, B.;

    2010-01-01

    Earlier work [T. Clarysse , Mater. Sci. Eng., B 114-115, 166 (2004); T. Clarysse , Mater. Res. Soc. Symp. Proc. 912, 197 (2006)] has shown that only few contemporary tools are able to measure reliably (within the international technology roadmap for semiconductors specifications) sheet resistances...... on ultrashallow (sub-50-nm) chemical-vapor-deposited layers [T. Clarysse , Mater. Res. Soc. Symp. Proc. 912, 197 (2006)], especially in the presence of medium/highly doped underlying layers (representative for well/halo implants). Here the authors examine more closely the sheet resistance anomalies...

  17. On the momentum distribution of particles participating in nuclear stopping

    Indian Academy of Sciences (India)

    Mandeep Kaur; Suneel Kumar

    2015-01-01

    Nuclear stopping is studied as a function of incident energy and charge of the fragment produced in central heavy-ion collisions (HIC) of $^{197}_{79}$Au+$^{197}_{79}$Au and $^{58}_{28}$Ni+$^{58}_{28}$Ni using stopping parameter VARXZ. Various momentum constraints were imposed to get better insight into the stopping. The comparison of measured and calculated values of stopping for protons reveals the significance of these constraints. Maximum stopping is obtained for the particles lying in the lowest range of the momentum distribution at all incident energies.

  18. Didactic Contracts in Realistic Mathematics Education Teaching Practice in Indonesia: A lesson on addition

    DEFF Research Database (Denmark)

    Putra, Zetra Hainul

    This paper aims to investigate characterize features of didactic contracts in realistic mathematics education teaching practice in Indonesia in the case of a lesson on addition. We just focus on some episodes of 26 first grade students and a female teacher from SDN 197 Palembang learning combinat......This paper aims to investigate characterize features of didactic contracts in realistic mathematics education teaching practice in Indonesia in the case of a lesson on addition. We just focus on some episodes of 26 first grade students and a female teacher from SDN 197 Palembang learning...

  19. Discussion on the material of chlorate decomposition tank%氯酸盐分解槽材质的探讨

    Institute of Scientific and Technical Information of China (English)

    钱碧峰

    2005-01-01

    为寻求合适的氯酸盐分解槽材质,选取了金属钛、海特隆197玻璃钢、DERAKANE470玻璃钢3种材质进行腐蚀试验对比,结果认为:金属钛耐高温氯酸盐腐蚀,但价格昂贵;海特隆197玻璃钢性能不理想; DERAKANE470玻璃钢耐高温氯酸盐性能较理想,使用寿命、价格适中.

  20. The importance of four histidine residues in isocitrate lyase from Escherichia coli.

    OpenAIRE

    Diehl, P; McFadden, B A

    1994-01-01

    By site-directed mutagenesis, substitutions were made for His-184 (H-184), H-197, H-266, and H-306 in Escherichia coli isocitrate lyase. Of these changes, only mutations of H-184 and H-197 appreciably reduced enzyme activity. Mutation of H-184 to Lys, Arg, or Leu resulted in an inactive isocitrate lyase, and mutation of H-184 to Gln resulted in an enzyme with 0.28% activity. Nondenaturing polyacrylamide gel electrophoresis demonstrated that isocitrate lyase containing the Lys, Arg, Gln, and L...

  1. Azimutal anisotropic particle emission in relativistic heavy-ion collisions

    International Nuclear Information System (INIS)

    This thesis deals with the evaluation of one of the first experiments perforemd at the kaon spectrometer. In this experiment the 197Au+197Au reactions were measured at a beam energy of 1 GeV per nucleon. The essential results of the evaluation can be summarized as following: The widths of the measured distributions of the transverse momenta per nucleon of projectile spectators of different charge cannot be explained solely by Fermi-gas models. For particles of different fragment charge the mean transverse-momentum transfers per nucleon into the reaction plane at projectile rapidity were determined. (HSI)

  2. Creating a system of medical and psychological rehabilitation of extreme professions representatives (firemen-rescuers as a model)

    OpenAIRE

    Chumaeva, Julia; Golikovа, Vladislava; Nekhoroshkova, Julia; Ogulenko, Alexey; Shafran, Leonid

    2015-01-01

    Chumaeva Julia, Golikovа Vladislava, Nekhoroshkova Julia, Ogulenko Alexey, Shafran Leonid. Creating a system of medical and psychological rehabilitation of extreme professions representatives (firemen-rescuers as a model). Journal of Education, Health and Sport. 2015;5(8):197-209. ISSN 2391-8306. DOI 10.5281/zenodo.28064 http://dx.doi.org/10.5281/zenodo.28064 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%288%29%3A197-209 https://pbn.nauka.gov.pl/works/6...

  3. Microscopic analysis of p^{10}B scattering at the intermediate energies

    CERN Document Server

    Dzhazairov-Kahramanov, Albert; Krassovitskiy, Pavel

    2016-01-01

    The differential cross sections of the p^{10}B scattering at energies of 197, 600 and 1000 MeV have been calculated within the framework of the Glauber theory. The operator of multiple scattering takes into account the contributions of single and double collisions. The contributions from protons scattering on the nucleons of different shells have been estimated in the single-scattering cross-section. The comparison with the experiment at 197 MeV and with DWBA calculation showed the adequate description of cross-sections in the region of the front angles.

  4. Predicting Sense of Efficacy and Teachers' Job Satisfaction of Teachers from Their Perceptions of the Decision Participation

    Science.gov (United States)

    Van Dat, Tran

    2016-01-01

    This study examines the hypothesis that teachers' perceptions of the decision participation may predict their teaching efficacy and job satisfaction. It examines data obtained from 197 secondary school teachers from 6 secondary schools to identify how teachers' perception of the decision participation varies, and the extent to which this predict…

  5. Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery

    DEFF Research Database (Denmark)

    Jensen, L S; Andersen, A J; Christiansen, P M;

    1992-01-01

    The frequency of infection in 197 patients undergoing elective colorectal surgery and having either no blood transfusion, transfusion with whole blood, or filtered blood free from leucocytes and platelets was investigated in a prospective randomized trial. Natural killer cell function was measure...

  6. Pion reabsorption in heavy-ion collisions interpreted in terms of the Delta capture process

    NARCIS (Netherlands)

    Holzmann, R; Schubert, A; Hlavac, S; Kulessa, R; Niebur, W; Simon, RS; Lautridou, P; Lefevre, F; Marques, M; Matulewicz, T; Mittig, W; Ostendorf, RW; RousselChomaz, P; Schutz, Y; Lohner, H; vanPol, JHG; Siemssen, RH; Wilschut, HW; Ballester, F; Diaz, J; Marin, A; Martinez, G; Metag, [No Value; Novotny, R; Wagner, [No Value; Quebert, J

    1996-01-01

    We have measured energy-differential cross sections for pi(0) production in Ar-36 + (197)AU collisions at 95 MeV/u. From an analysis of spectral features due to pion final-state interactions we have estimated the cross section of the capture process Delta + N --> N + N in the center-of-mass energy r

  7. Efectos del tipo de diabetes, estrategias de afrontamiento, sexo y optimismo en el apoyo social

    OpenAIRE

    Rondón, José E.; Lugli, Zoraide

    2013-01-01

    Se desea conocer el efecto del tipo de diabetes, las estrategias de afrontamiento, el sexo, y el optimismo sobre las redes sociales y el apoyo social percibido por sujetos con diabetes. Participaron 103 hombres y 197 mujeres divididos en diabéticos tipo

  8. Performance evaluation of compounding and directional beamforming techniques for carotid strain imaging using plane wave transmissions

    DEFF Research Database (Denmark)

    Hansen, Hendrik H.G.; Stuart, Matthias Bo; Villagómez Hoyos, Carlos Armando;

    2014-01-01

    using linear array ultrasound data of a pulsating concentric homogeneous artery simulated using Field II . The transducer ( f c = 9 MHz, pitch = 197.9 μ m, 192 elements, f s = 180 MHz) transmitted plane waves at 3 sequentially alternating angles (0°, + θ , - θ ) at a PRF of 2 kHz. Simulations were...

  9. An evaluation of calculation procedures affecting the constituent factors of equivalent circulating density for drilling hydraulics

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, William J.

    1996-12-31

    This Dr. ing. thesis covers a study of drilling hydraulics offshore. The purpose of drilling hydraulics is to provide information about downhole pressure, suitable surface pump rates, the quality of hole cleaning and optimum tripping speeds during drilling operations. Main fields covered are drilling hydraulics, fluid characterisation, pressure losses, and equivalent circulating density. 197 refs., 23 figs., 22 tabs.

  10. Light-ion-induced multifragmentation. A fast, evolutionary process

    International Nuclear Information System (INIS)

    GeV light-ion-induced reactions offer a unique tool for preparing hot, dilute nuclear matter. Time evolution of nuclear multifragmentation in 3He + natAg and 3He + 197Au reactions are investigated. Fragment-fragment correlations are studied in order to gain information on multifragmentation mechanism. (K.A.)

  11. The other hip in unilateral hip dysplasia

    DEFF Research Database (Denmark)

    Jacobsen, Steffen; Rømer, Lone; Søballe, Kjeld

    2006-01-01

    We reviewed transverse pelvic computed tomography scans of 197 consecutively referred adult patients with hip pain thought to be secondary to developmental dysplasia. A center-edge angle of 20 degrees or less was considered the upper normal value. Four groups were identified: 69 patients with app...

  12. Assessment of menstrual characteristics among nulliparous female consumers of carbonated soft drinks

    Directory of Open Access Journals (Sweden)

    Ologhaguo M. Adienbo

    2016-01-01

    Conclusions: This study has shown that consumption of soft drinks during menstruation could alter menstrual characteristics in nulliparous females by increasing the menstrual flow, menstrual pain and menstrual duration. [Int J Reprod Contracept Obstet Gynecol 2016; 5(1.000: 194-197

  13. Rahvused ja rahvuslus / Ernest Gellner ; tõlk. A. Andresson

    Index Scriptorium Estoniae

    Gellner, Ernest

    1994-01-01

    Järg 1994/Nov nr. 11 lk. 2429-2462; Dec nr. 12 lk. 2653-2686; 1995/Jan nr. 1. lk. 197-222, Feb nr. 2 lk. 419-446. Toimetaja eessõna: Jaan Isotamm, lk. 2209-2218; 1995/Mar nr. 3 lk. 643-670; Järels. E. Loone. Rahvus. Rahvuslus. Rahvas. Riik. Ühiskond. Kultuur

  14. 9 CFR 94.23 - Importation of poultry meat and other poultry products from Sinaloa and Sonora, Mexico.

    Science.gov (United States)

    2010-01-01

    ... United States in accordance with 9 CFR 381.196. (b) If processed, the poultry meat or other poultry... accompanying the poultry meat or other poultry products (required by 9 CFR 381.197) includes statements... poultry products from Sinaloa and Sonora, Mexico. 94.23 Section 94.23 Animals and Animal Products...

  15. GEOTHERMICS GEOLOGY

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    <正>20131088 Fan Difu (Geological Survey of Jiangsu Province , Nanjing 210018 , China ); Xu Xueqiu Origin Study of Geothermal Field in Xiaoyangkou of Rudong County in Jiangsu (Journal of Geology , ISSN1674-3636 , CN32-1796/P , 36 (2), 2012 , p.192-197 , 3illus. , 9refs.) Key words : geothermal fields , Jiangsu Province

  16. Second generation sequencing of three STRs D3S1358, D12S391 and D21S11 in Danes and a new nomenclature for sequenced STR alleles

    DEFF Research Database (Denmark)

    Gelardi, Chiara; Rockenbauer, Eszter; Dalsgaard, Sigrun;

    2014-01-01

    report the STR sequences and allele frequencies of three STR loci: D3S1358, D12S391 and D21S11 in 197 unrelated Danes. We used a new STR nomenclature that depicts the locus name used in forensic genetics, the length of the repeat region divided by the repeat length (typically 4 nucleotides) and detailed...

  17. Textile & Garment Export Situation from five Provinces in Nov

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Guangdong:The Decline Trend of Export Growth Rate Slowered In the first 11 months of 2008,the export of textile and garment in Guangdong province reached 30.8 billion USD,down 19.7%on the same periond of previous

  18. Diesel exhaust emissions (citations from the American Petroleum Institute Data Base). Report for 1974-Dec 1980

    Energy Technology Data Exchange (ETDEWEB)

    Cavagnaro, D.M.

    1980-02-01

    This bibliography cites research reports concerning exhaust emissions from diesel motor vehicles. Topics include engine design, techniques of measuring gases, pollution control, and fuel additives. (This updated bibliography contains 197 abstracts, 42 of which are new entries to the previous edition.)

  19. [Fast neutron cross section measurements

    International Nuclear Information System (INIS)

    This paper discusses the following topics: 14 MeV pulsed neutron facility; detection and measurement system; 238U capture cross sections at 23 and 964 keV using photon neutron sources; capture cross sections of Au-197 at 23 and 964 keV; and yttrium nuclear cross section measurement

  20. Psychometric Evaluation of the Beck Anxiety Inventory with Older Medical Patients.

    Science.gov (United States)

    Wetherell, Julie Loebach; Arean, Patricia A.

    1997-01-01

    When 197 disadvantaged older medical patients completed the Beck Anxiety Inventory, the instrument demonstrated high internal consistency and no significant differences by sex or race, suggesting that it is appropriate for use with diverse populations. Total instrument scores correlated negatively with age. (SLD)

  1. The Relationship of Public Relations and Board-Level Boundary-Spanning Roles to Corporate Social Responsibility.

    Science.gov (United States)

    Ferguson, Mary Ann; And Others

    The annual reports of 197 publicly held American corporations were analyzed to determine the relationship of corporate social responsibility activities to boundary-spanning activities (attempts to relate the firm to the outside world). Data gathered included (1) the number of directors from inside and outside a corporation, (2) the number of…

  2. Bewakingsonderzoek 1994 naar het voorkomen van residuen van beta-agonisten, gestagenen en tranquillizers in slachtdieren

    NARCIS (Netherlands)

    Stolker AAM; Rossum HJ van; Schwillens PLWJ; Zoontjes PW; Hagele GH; Janssen FW; Stephany RW; Ginkel LA van; ARO

    1996-01-01

    Gedurende het in 1994 uitgevoerde bewakingsonderzoek 'bijzondere slachtplaatsen' werden 196 monsters lever en 147 monsters urine onderzocht op de aanwezigheid van residuen van beta-agonisten, 197 monsters niervet werden onderzocht op de aanwezigheid van gestagenen en 141 monsters nier

  3. The Effect of Kindergarten Entry Age on Academic Achievement

    Science.gov (United States)

    Buten, Nicole A.

    2010-01-01

    This study examined the effect of kindergarten entry age on the scores of the eighth grade Comprehensive Test of Basic Skills (CTBS) math and reading scores, while controlling for the demographic variables of gender and socioeconomic status. The subjects included 1,197 students who participated in the randomized, long-term STAR (Student-Teacher…

  4. The Relevance of Depressive Symptoms and Social Support to Disability in Women with Multiple Sclerosis or Fibromyalgia

    Science.gov (United States)

    Phillips, Lorraine J.

    2010-01-01

    Multiple sclerosis and fibromyalgia syndrome may spur substantial disability for those affected. Using structural equation modeling, this secondary analysis examined predictors of disability in women with multiple sclerosis (n = 118) and fibromyalgia syndrome (n = 197) recruited for separate wellness studies. Greater functional limitations, lower…

  5. Molecular Typing of Treponema pallidum in Denmark

    DEFF Research Database (Denmark)

    Salado-Rasmussen, Kirsten; Cowan, Susan; Gerstoft, Jan;

    2016-01-01

    strain typing was based on characterization of 3 variable treponemal genes, arp, tpr and tp0548. A total of 278 specimens from 269 patients were included. Among the fully typeable specimens (n = 197), 22 strain types were identified, with 1 type, 14d/g, accounting for 54%. The majority (93...

  6. Industrial Maintenance, Volume II-A. Post Secondary Curriculum Guide.

    Science.gov (United States)

    Butler, Raymond H.; And Others

    This volume is the second of four volumes that comprise a curriculum guide for a postsecondary industrial maintenance program. It contains part of section 3 of the guide which contains the unit guides for two of the 12 duties included in the course. Each of the 197 tasks included in these two duties is presented on a separate page and contains the…

  7. Industrial Provision of Practice Skills of Students Training Gastronomy Education (Case of Turkey)

    Science.gov (United States)

    Sarioglan, Mehmet

    2013-01-01

    Purpose of this study is to determine to what extent practice skills of students, training in gastronomy education, meet the expectations of food and beverage industry. In the study, 197 students training internship in 27 different firms of total 1540 students training in gastronomy education at higher education level in Turkey were reached by…

  8. Domain Modeling: NP_001009882.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001009882.1 chr1 Crystal structure of human myristoyl-CoA:protein N-myristoyltra...nsferase. d1rxta_ chr1/NP_001009882.1/NP_001009882.1_apo_91-233.pdb c1rxtc_ chr1/NP_001009882.1/NP_001009882.1_holo_91-233.pdb forte 197E CMO 1 ...

  9. Emotional and Personality-Related Aspects of Career Decision-Making Difficulties: Facets of Career Indecisiveness

    Science.gov (United States)

    Gati, Itamar; Gadassi, Reuma; Saka, Noa; Hadadi, Yael; Ansenberg, Neta; Friedmann, Ronit; Asulin-Peretz, Lisa

    2011-01-01

    The current study investigated the Emotional and Personality-related Career decision-making Difficulties model and questionnaire (EPCD) by studying its associations with various personality measures in three samples: (a) 691 deliberating individuals who entered a career self-help website, (b) 197 students in a university preparatory program, and…

  10. Partner relationships in the Netherlands : New manifestations of the Second Demographic Transition

    NARCIS (Netherlands)

    Latten, Jan J.; Mulder, Clara H.

    2013-01-01

    Partnership formation has rapidly and profoundly changed in theNetherlandssince the 1960s.Several scholars have placed these changes in the context of the Second Demographic Transition. We describe the main trends in the formation and dissolution of partnerships in theNetherlandsbetween the 1960/197

  11. The Natural History of Nursing Home Patients.

    Science.gov (United States)

    Lewis, Mary Ann; And Others

    1985-01-01

    Former nursing home residents (N=197) were followed for 2 years after discharge. Four subgroups of patients were identified on the basis of different patterns of survival and use of health care resources: those who returned home, died in nursing homes, transferred to hospitals, or transferred to other nursing homes. (NRB)

  12. In New York, Adult Students Say Real-Life Struggles Define Their Politics

    Science.gov (United States)

    Sander, Libby

    2008-01-01

    For adult students at Lehman College, in the Bronx, and LaGuardia Community College, in Queens, the separation between politics and daily life seems practically invisible. Both colleges are part of the 23-campus CUNY system, where more than two in five of the nearly 197,000 students are 23 and older. For most of these students, it is nearly…

  13. Hospital volume and post-operative mortality after resection for gastric cancer

    NARCIS (Netherlands)

    Damhuis, RAM; Meurs, CJC; Dijkhuis, CM; Stassen, LPS; Wiggers, T

    2002-01-01

    Aims: In low-volume hospitals, expertise in gastric surgery is difficult to maintain because of the decreasing incidence of gastric cancer and the fall of surgery for ulcer disease. We evaluated the prognostic impact of hospital volume on post-operative mortality (POM) in a consecutive series of 197

  14. EST Table: BB985987 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BB985987 E_ET_MSV3_12C07_F_0 10/09/28 91 %/197 aa ref|NP_001166288.1| sericin 2 iso...form 2 precursor [Bombyx mori] gb|ADB04958.1| sericin 2 precursor [Bombyx mori] 10/08/28 low homology 10/08/

  15. 46 CFR 30.25-3 - Benzene.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Benzene. 30.25-3 Section 30.25-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Commodities Regulated § 30.25-3 Benzene. The provisions contained in 46 CFR part 197, subpart C, apply to liquid cargoes containing 0.5% or more...

  16. Study of gold induced heavy ion collisions using isospin dependent QMD model

    CERN Document Server

    Sharma, Bhawna; Kumar, Suneel; Puri, Rajeev K

    2010-01-01

    We have studied the fragment production mechanism in the set of four reactions 197Au79+12C6, 197Au79+26Al13, 197Au79+63Cu29 and 197Au79+208Pb82. The reactions are simulated at an energy 600 MeV/nucleon and collision geometry is varied from central to peripheral (= b/bmax = 0 to 1). A theoretical investigation has been carried out on the study of mass dependence of intermediate mass fragments (5\\leqA\\leqAtot/6) and other fragments. It is observed that multiplicity shows a good agreement for low Zbound, but it fails for high Zbound. This failure is due the method of analysis MST which we had used in our analysis, because MST method gives one heavy cluster at the time of high density. The discrepancy between theory and experiments can be removed by using reduced isospin dependent NN cross section and sophisticated clustrization algorithm SACA.

  17. The Prospective Oral Mucositis Audit: relationship of severe oral mucositis with clinical and medical resource use outcomes in patients receiving high-dose melphalan or BEAM-conditioning chemotherapy and autologous SCT.

    NARCIS (Netherlands)

    McCann, S.; Schwenkglenks, M.; Bacon, P.; Einsele, H.; D'Addio, A.; Maertens, J.; Niederwieser, D.; Rabitsch, W.; Roosaar, A.; Ruutu, T.; Schouten, H.; Stone, R.; Vorkurka, S.; Quinn, B.; Blijlevens, N.M.A.

    2009-01-01

    The Prospective Oral Mucositis Audit was an observational study in 197 patients with multiple myeloma (MM) or non-Hodgkin's lymphoma (NHL) undergoing, respectively, high-dose melphalan or BEAM chemotherapy and autologous SCT at 25 European centres. We evaluated the relationship between severe oral m

  18. Draft Genome Sequence of the Yeast Pseudozyma antarctica Type Strain JCM10317, a Producer of the Glycolipid Biosurfactants, Mannosylerythritol Lipids.

    Science.gov (United States)

    Saika, Azusa; Koike, Hideaki; Hori, Tomoyuki; Fukuoka, Tokuma; Sato, Shun; Habe, Hiroshi; Kitamoto, Dai; Morita, Tomotake

    2014-01-01

    The basidiomycetous yeast Pseudozyma antarctica is known as a producer of industrial enzymes and the extracellular glycolipids, mannosylerythritol lipids. Here, we report the draft genome sequence of the type strain JCM10317. The draft genome assembly has a size of 18.1 Mb and a G+C content of 60.9%, and it consists of 197 scaffolds. PMID:25291760

  19. Lung problems and volcanic smog

    Science.gov (United States)

    ... www.ncbi.nlm.nih.gov/pubmed/17650330 . Volcanic Air Pollution -- A Hazard in Hawai'i. U.S. Geological Survey. Last updated October 2004. U.S. Geological Survey Fact Sheet 169-197. Accessed April 22, 2012. Available at: ...

  20. Measurement of HOMs in the RHIC RF Cavities

    Energy Technology Data Exchange (ETDEWEB)

    Abreu,N.P.; Choi, E. M.

    2009-01-07

    The authors present results of Higher Order Modes (HOMs) measurements in the RHIC accelerating (28 MHz system) and storage (197 MHz system) cavities. The power of the excited HOMs deposited into the HOM damper is measured and compared with an analytical calculation of the HOMs power. The quality factors (Q) are also measured and compared to previous measurements.

  1. Mating type idiomorphs distribution and their correlation to benzimidazole-resistance in Cercospora beticola from the Central High Plains Region, USA

    Science.gov (United States)

    Cercospora leaf spot (CLS) of sugarbeet is caused by Cercospora beticola Sacc., and is one of the most destructive foliar diseases worldwide. Fungicides used for disease suppression include benzimidazoles. Resistance to benzimidazoles can develop quickly, and was first reported in C. beticola in 197...

  2. Biodiversity of shallow-water sponges (Porifera) in Singapore and description of a new species of Forcepia (Poecilosclerida: Coelosphaeridae)

    NARCIS (Netherlands)

    Lim, S.-C.; Voogd, de N.J.; Tan, K.-S.

    2012-01-01

    A surprisingly high number of shallow water sponge species (197) were recorded from extensive sampling of natural intertidal and subtidal habitats in Singapore (Southeast Asia) from May 2003 to June 2010. This is in spite of a highly modified coastline that encompasses one of the world’s largest con

  3. A quinoxaline urea analog uncouples inflammatory and pro-survival functions of IKKβ.

    Science.gov (United States)

    Maroni, Dulce; Rana, Sandeep; Mukhopadhyay, Chandrani; Natarajan, Amarnath; Naramura, Mayumi

    2015-12-01

    Activation of the NF-κB pathway is causally linked to initiation and progression of diverse cancers. Therefore, IKKβ, the key regulatory kinase of the canonical NF-κB pathway, should be a logical target for cancer treatment. However, existing IKKβ inhibitors are known to induce paradoxical immune activation, which limits their clinical usefulness. Recently, we identified a quinoxaline urea analog 13-197 as a novel IKKβ inhibitor that delays tumor growth without significant adverse effects in xenograft tumor models. In the present study, we found that 13-197 had little effect on LPS-induced NF-κB target gene induction by primary mouse macrophages while maintaining considerable anti-proliferative activities. These characteristics may explain absence of inflammatory side effects in animals treated with 13-197. Our data also demonstrate that the inflammation and proliferation-related functions of IKKβ can be uncoupled, and highlight the utility of 13-197 to dissect these downstream pathways.

  4. The Sun Sense Study: An Intervention to Improve Sun Protection in Children

    Science.gov (United States)

    Glasser, Alice; Shaheen, Magda; Glenn, Beth A.; Bastani, Roshan

    2010-01-01

    Objectives: To assess the effect of a multicomponent intervention on parental knowledge, sun avoidance behaviors, and sun protection practices in children 3-10 years. Methods: A randomized trial at a pediatric clinic recruited 197 caregiver-child pairs (90% parents). Intervention included a brief presentation and brochure for the parent and…

  5. On the kinetics of platinum silicide formation

    NARCIS (Netherlands)

    Faber, Erik J.; Wolters, Rob A.M.; Schmitz, Jurriaan

    2011-01-01

    In this work, the kinetics of platinum silicide formation for thin Pt films (50 nm) on monocrystalline <100> silicon is investigated via in situ resistance measurements under isothermal (197–275 °C) conditions. For Pt2Si diffusion limited growth was observed. For PtSi formation, however, no linear r

  6. Use of cephalosporins during pregnancy and in the presence of congenital abnormalities: a population-based, case-control study

    DEFF Research Database (Denmark)

    Czeizel, A.E.; Rockenbauer, M.; Sørensen, Henrik Toft;

    2001-01-01

    delivered of babies affected with Down syndrome (patient controls). Results: In the case group, 308 (1.35%) pregnant women were treated with cephalosporin. In the population and patient control groups, 440 (1.15%) and 16 (1.97%) pregnant women had similar treatments. The somewhat higher use...

  7. Rotational Period Determination for (8563) 1995 US

    Science.gov (United States)

    Papini, Riccardo; Marchini, Alessandro; Marullo, Sara; Salvaggio, Fabio

    2016-01-01

    Analysis of photometric observations in 2015 August of the main-belt asteroid (8563) 1995 US found the most likely synodic period to be 3.197 ± 0.001 hours with a lightcurve amplitude of 0.56 ± 0.03 mag.

  8. EST Table: FS868421 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS868421 E_FL_fner_36N05_R_0 10/09/28 98 %/197 aa ref|NP_001040402.1| preimplantation... protein [Bombyx mori] gb|ABF51322.1| preimplantation protein [Bombyx mori] 10/09/11 81 %/198 aa FBpp02771

  9. EST Table: FY743324 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY743324 E_FL_famL_20O01_F_0 11/11/04 98 %/207 aa ref|NP_001040402.1| preimplantation... protein [Bombyx mori] gb|ABF51322.1| preimplantation protein [Bombyx mori] 11/11/04 86 %/197 aa FBpp02522

  10. EST Table: FY756405 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY756405 E_FL_famL_20O01_R_0 11/11/04 97 %/196 aa ref|NP_001040402.1| preimplantation... protein [Bombyx mori] gb|ABF51322.1| preimplantation protein [Bombyx mori] 11/11/04 80 %/197 aa FBpp02771

  11. IGNEOUS PETROLOGY

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    <正>20090158 Bai Daoyuan (Hunan Institute of Geological Survey, Xiangtan 411100, China); Zhou Liang Genesis and Tectonic Setting of Indosinian Granites in Southeast Hunan Province (Acta Petrologica et Mineralogica, ISSN1000-6524, CN11-1966/P, 26(3), 2007, p.197-212, 8 illus., 3 tables, 77 refs.)

  12. Authentication of Algorithm to Detect Metastases in Men with Prostate Cancer Using ICD-9 Codes

    Directory of Open Access Journals (Sweden)

    Matthew T. Dolan

    2012-01-01

    Full Text Available Background. Metastasis is a crucial endpoint for patients with prostate cancer (PCa, but currently lacks a validated claims-based algorithm for detection. Objective. To develop an algorithm using ICD-9 codes to facilitate accurate reporting of PCa metastases. Methods. Medical records from 300 men hospitalized at Robert Wood Johnson University Hospital for PCa were reviewed. Using the presence of metastatic PCa on chart review as the gold standard, two algorithms to detect metastases were compared. Algorithm A used ICD-9 codes 198.5 (bone metastases, 197.0 (lung metastases, 197.7 (liver metastases, or 198.3 (brain and spinal cord metastases to detect metastases, while algorithm B used only 198.5. Sensitivity, specificity, positive predictive value (PPV, and negative predictive value (NPV for the two algorithms were determined. Kappa statistics were used to measure agreement rates between claim data and chart review. Results. Algorithm A demonstrated a sensitivity, specificity, PPV, and NPV of 95%, 100%, 100%, and 98.7%, respectively. Corresponding numbers for algorithm B were 90%, 100%, 100%, and 97.5%, respectively. The agreement rate is 96.8% for algorithm A and 93.5% for algorithm B. Conclusions. Using ICD-9 codes 198.5, 197.0, 197.7, or 198.3 in detecting the presence of PCa metastases offers a high sensitivity, specificity, PPV, and NPV value.

  13. 77 FR 68567 - Announcement of Funding Awards for the Continuum of Care Program for Fiscal Year (FY) 2011

    Science.gov (United States)

    2012-11-15

    ... 63,625 Lighthouse Counseling Center, Inc.... AL 197,854 Mental Health Center of North Central AL 131... YWCA CENTRAL ALABAMA AL 83,867 YWCA CENTRAL ALABAMA AL 184,285 Arkansas Department of Human Services AR... CA 133,333 Abode Services CA 852,468 Affordable Housing Associates........ CA 36,665 Alameda...

  14. 19 CFR Appendix A to Part 171 - Guidelines for Disposition of Violations of 19 U.S.C. 1497

    Science.gov (United States)

    2010-04-01

    .... There is behavior, including extreme lack of cooperation, verbal or physical abuse, or attempted escape... where appropriate. 4. The rate of duty to be used in calculating the mitigated penalty shall be the appropriate rate from Chapters 1-97, HTSUS, and not the flat rate from Chapter 98, HTSUS. 5. “Duty”...

  15. The Effects of Sex and Gender Role Identity on Perceived Stress and Coping among Traditional and Nontraditional Students

    Science.gov (United States)

    Jones, Kayla; Mendenhall, Sarah; Myers, Charlsie A.

    2016-01-01

    Objective: This study examined differences in perceived stress and coping strategies based on gender role identity (GRI) and sex among traditional and nontraditional college students. Participants and Methods: Online surveys that assessed demographic information, GRI, and perceived stress were completed between October 2013 and March 2014 by 197

  16. Gender, Ethnicity, and Social Cognitive Factors Predicting the Academic Achievement of Students in Engineering.

    Science.gov (United States)

    Hackett, Gail; And Others

    1992-01-01

    Examined relationships of measures of occupational and academic self-efficacy; vocational interests; outcome expectations; academic ability; and perceived stress, support, and coping to academic achievement of engineering/science majors (n=197). Self-efficacy for academic milestones, in combination with other academic and support variables, was…

  17. STR data for the 13 CODIS loci in Singapore Malays.

    Science.gov (United States)

    Ang, H C; Sornarajah, R; Lim, S E S; Syn, C K C; Tan-Siew, W F; Chow, S T; Budowle, Bruce

    2005-03-10

    Allele frequencies for the 13 CODIS (Combined DNA Index System, USA) STR loci included in the AmpFISTR Profiler Plus and AmpFISTR Cofiler kits (Applied Biosystems, Foster City, USA) were determined in a sample of 197 unrelated Malays in Singapore.

  18. Questionnaire-based survey of parturition in the queen

    NARCIS (Netherlands)

    Musters, J.; de Gier, J.; Kooistra, H.S.; Okkens, A.C.

    2011-01-01

    The lack of scientific data concerning whether parturition in the queen proceeds normally or not may prevent veterinarians and cat owners from recognizing parturition problems in time. A questionnaire-based study of parturition in 197 queens was performed to determine several parameters of parturiti

  19. Integrating Technology during Student Teaching: An Examination of Teacher Work Samples

    Science.gov (United States)

    Henning, John E.; Robinson, Victoria L.; Herring, Mary Corwin; McDonald, Terri

    2007-01-01

    This study examined the teacher work samples of 197 student teachers to determine their level of technology integration during student teaching. Findings indicated that most student teachers planned to use some kind of technology, although only 40% planned to include computers and less than 20% planned for the use of computers by students. The…

  20. A search for single radio pulses and bursts from southern AXPs

    NARCIS (Netherlands)

    F. Crawford; J.W.T. Hessels; V.M. Kaspi

    2007-01-01

    We observed four southern AXPs in 1999 near 1400 MHz with the Parkes 64-m radio telescope to search for periodic radio emission. No Fourier candidates were discovered in the initial analysis, but the recent radio activity observed for the AXP XTE J1810-197 has prompted us to revisit these data to se

  1. The Effect of Automatic Thoughts on Hopelessness: Role of Self-Esteem as a Mediator

    Science.gov (United States)

    Cakar, Firdevs Savi

    2014-01-01

    The purpose of this study is to test a theoretical model concerning the role of self-esteem as a mediator between university students' automatic thoughts and their levels of hopelessness. The participants consisted of 338 students (197 females (58.3%) and 141 males (41.7%) from various departments at the Celal Bayar University. The research…

  2. Drug: D09763 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available iol (USAN); Forxiga (TN) C21H25ClO6. C3H8O2. H2O 502.197 502.9823 D09763.gif Antidiabetic [DS:H00408 H00409]... ATC code: A10BX09 sodium glucose co-transporter2 (SGLT2) inhibitor [HSA:6524] [KO:K14382] map07051 Antidiabetic

  3. The Role of Goal Importance in Predicting University Students' High Academic Performance

    Science.gov (United States)

    Kyle, Vanessa A.; White, Katherine M.; Hyde, Melissa K.; Occhipinti, Stefano

    2014-01-01

    We examined goal importance, focusing on high, but not exclusive priority goals, in the theory of planned behaviour (TPB) to predict students' academic performance. At the beginning of semester, students in a psychology subject (N = 197) completed TPB and goal importance items for achieving a high grade. Regression analyses revealed partial…

  4. EST Table: NM_001172720 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available NM_001172720 cact 10/09/29 95 %/326 aa ref|NP_001166191.1| cactus [Bombyx mori] dbj...10/09/10 39 %/197 aa gnl|Amel|GB10655-PA 10/09/10 35 %/291 aa gi|270016252|gb|EFA12698.1| cactus [Tribolium castaneum] AV404402 ...

  5. Understanding Nonsmoking in African American and Caucasian College Students: An Application of the Theory of Planned Behavior

    Science.gov (United States)

    Nehl, Eric J.; Blanchard, Chris M.; Peng, Chao-Ying J.; Rhodes, Ryan E.; Kupperman, Janet; Sparling, Phillip B.; Courneya, Kerry; Baker, Frank

    2009-01-01

    Few studies have considered whether psychological determinants of nonsmoking among college students vary by ethnicity. The authors tested the theory of planned behavior (TPB) to explain differences in nonsmoking intentions of 238 African American and 197 Caucasian college students who completed an in-class TPB questionnaire and a smoking…

  6. Attitudes toward Euthanasia in Hong Kong--A Comparison between Physicians and the General Public

    Science.gov (United States)

    Chong, Alice Ming-lin; Fok, Shiu-yeu

    2005-01-01

    This article reports the findings of a cross-sectional study that compared the attitudes of 618 respondents of a general household survey and a random sample of 1,197 physicians toward different types of euthanasia in Hong Kong. The general public was found to agree with active euthanasia and non-voluntary euthanasia and was neutral about passive…

  7. The synergy in green persuasion: Green celebrity endorsers in green advertising: A study of brand-endorser congruence effects in green advertising

    NARCIS (Netherlands)

    Blasche, J.; Ketelaar, P.E.

    2015-01-01

    This study examines celebrity endorser-brand congruence effects in green advertising on the ads' effectiveness. In an experimental survey, Dutch participants (197) saw ads with a congruent or incongruent celebrity endorser. Extending the match-up hypothesis to a novel match-up factor, greenness, the

  8. Partner relationships in the Netherlands: new manifestations of the Second Demographic Transition

    NARCIS (Netherlands)

    J.J. Latten; C.H. Mulder

    2013-01-01

    Partnership formation has rapidly and profoundly changed in theNetherlandssince the 1960s.Several scholars have placed these changes in the context of the Second Demographic Transition. We describe the main trends in the formation and dissolution of partnerships in theNetherlandsbetween the 1960/197

  9. Comparison of early complications using regular mesh versus Atramat and reg; Neoflex 25 mesh in inguinal, umbilical and post incisional hernias

    Directory of Open Access Journals (Sweden)

    Juan Jos and eacute; Granados-Romero

    2016-01-01

    Conclusions: Using Atramat and reg; Neoflex 25 mesh demonstrated a significant reduction of complications (recurrence and seroma formation and length of hospital stay (2 days vs 1 day in abdominoplasty after surgery. [Int J Res Med Sci 2016; 4(1.000: 194-197

  10. Obesity of women in Jordan - Prevalence and associated factors : making a case for a comprehensive obesity policy

    NARCIS (Netherlands)

    Göllner, S.; Nimeh, Z.

    2014-01-01

    This paper analyses the current burden of obesity in the female population of Jordan on a national scale and examines the factors associated with it. Demographics and Health Surveys (DHS) were used for the years 2002, 2007 and 2009 covering a total of 23,197 women, 15-49 years of age, and variables

  11. 75 FR 2132 - Maine Maritime Academy; Notice of Declaration of Intention and Petition for Relief Filing and...

    Science.gov (United States)

    2010-01-14

    ... purposes, hydrokinetic devices that would be located at sites located in Bagaduce Narrows and Castine Harbor. The experimental hydrokinetic devices could include: (1) 4.9-foot-diameter, 19.7-foot-long 4... launches or barges. The hydrokinetic devices would convert mechanical power from the tidal currents and...

  12. Illustration of sampling-based approaches to the calculation of expected dose in performance assessments for the proposed high level radioactive waste repository at Yucca Mountain, Nevada.

    Energy Technology Data Exchange (ETDEWEB)

    Helton, Jon Craig (Arizona State University, Tempe, AZ); Sallaberry, Cedric J. PhD. (.; .)

    2007-04-01

    A deep geologic repository for high level radioactive waste is under development by the U.S. Department of Energy at Yucca Mountain (YM), Nevada. As mandated in the Energy Policy Act of 1992, the U.S. Environmental Protection Agency (EPA) has promulgated public health and safety standards (i.e., 40 CFR Part 197) for the YM repository, and the U.S. Nuclear Regulatory Commission has promulgated licensing standards (i.e., 10 CFR Parts 2, 19, 20, etc.) consistent with 40 CFR Part 197 that the DOE must establish are met in order for the YM repository to be licensed for operation. Important requirements in 40 CFR Part 197 and 10 CFR Parts 2, 19, 20, etc. relate to the determination of expected (i.e., mean) dose to a reasonably maximally exposed individual (RMEI) and the incorporation of uncertainty into this determination. This presentation describes and illustrates how general and typically nonquantitive statements in 40 CFR Part 197 and 10 CFR Parts 2, 19, 20, etc. can be given a formal mathematical structure that facilitates both the calculation of expected dose to the RMEI and the appropriate separation in this calculation of aleatory uncertainty (i.e., randomness in the properties of future occurrences such as igneous and seismic events) and epistemic uncertainty (i.e., lack of knowledge about quantities that are poorly known but assumed to have constant values in the calculation of expected dose to the RMEI).

  13. Fund af småsommerfugle fra Danmark i 2010 (Lepidoptera)

    DEFF Research Database (Denmark)

    Buhl, Otto; Falck, Per; Karsholt, Ole;

    2011-01-01

    ; Tortricidae 384; Epermeniidae 7; Pterophoridae 46 and Pyralidae 197; this results in a total of 1574 species of Microlepidoptera (families Micropterigidae-Pyralidae) found in Denmark. The total amount of Macrolepidoptera mentioned from Denmark is now 965, bringing the number of Danish Lepidoptera to a total...

  14. Selenium speciation and extractability in Dutch agricultural soils

    NARCIS (Netherlands)

    Supriatin, Supriatin; Weng, Liping; Comans, Rob N.J.

    2015-01-01

    The study aimed to understand selenium (Se) speciation and extractability in Dutch agricultural soils. Top soil samples were taken from 42 grassland fields and 41 arable land fields in the Netherlands. Total Se contents measured in aqua regia were between 0.12 and 1.97mgkg-1(on average

  15. Context-Dependent Victimization and Aggression: Differences between All-Girl and Mixed-Sex Schools

    Science.gov (United States)

    Velasquez, Ana Maria; Santo, Jonathan Bruce; Saldarriaga, Lina Maria; Lopez, Luz Stella; Bukowski, William M.

    2010-01-01

    Contextual differences in the association between different forms of aggressive behavior and victimization were studied with a sample of 197 boys and 149 girls from mixed-sex schools and in 336 girls from all-girl schools (M = 10.21 years of age) in two cities in Colombia. Results showed that boys generally engage in more physical than relational…

  16. Experiment list: SRX1090866 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available gramming || cell type=intermediate stage of somatic cell reprogramming || chip anti...1,96.8,4.5,197 GSM1816303: pre-iPS rep.H3K27me3.ChIP-Seq; Mus musculus; ChIP-Seq source_name=intermediate stage of somatic cell repro

  17. Breakup of the projectile in heavy ion collisions at intermediate energies

    International Nuclear Information System (INIS)

    Report on an experiment in which the 4He breakup channel of 16O projectiles on various targets (27Al, 58Ni, 197Au) has been studied inclusively, and exclusively (in coincidence with charged pions). The bombarding energy was 94 MeV/nucleon. (D.L.). 7 refs., 5 figs

  18. Work and Nonwork Predictors of Employees' Retirement Ages.

    Science.gov (United States)

    Beehr, Terry A.; Glazer, Sharon; Nielson, Norma L.; Farmer, Suzanne J.

    2000-01-01

    Three analyses of data from 197 older employees and their spouses identified work and nonwork factors influencing age of retirement. Finances predicted retirement but health and gender did not. Being tired of working and expecting to work for pay after retirement predicted earlier retirement. (SK)

  19. 29 CFR 1915.118 - Tables.

    Science.gov (United States)

    2010-07-01

    ... Rails of Ladders Length (in feet) Cross section (in inches) At ends At center 15 17/8 x 23/4 17/8 x 33/4... 116 197 250 303 (A)—Rough lumber. (B)—Dressed lumber. Table G-1—Manila Rope Circumferences Diameter...

  20. 77 FR 62121 - Guides for the Use of Environmental Marketing Claims

    Science.gov (United States)

    2012-10-11

    ....'' \\2\\ In October 2010, the Commission proposed changes to the 1998 Guides. 75 FR 63552 (Oct. 15, 2010... Marketing Claims; Final Rule #0;#0;Federal Register / Vol. 77 , No. 197 / Thursday, October 11, 2012 / Rules... Marketing Claims AGENCY: Federal Trade Commission. ACTION: Adoption of Revised Guides. SUMMARY: The...

  1. Dicty_cDB: VSH329 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 96315 |pid:none) Auxenochlorella protothecoides rib... 191 2e-65 protein update 2..... 197 7e-66 BC054263_1( BC054263 |pid:none) Xenopus laevis hypothetical protei... 195 1e-65 FJ196315_1( FJ1

  2. Emotional Abuse in a Sample of Multiply Maltreated, Urban Young Adolescents: Issues of Definition and Identification

    Science.gov (United States)

    Trickett, Penelope K.; Mennen, Ferol E.; Kim, Kihyun; Sang, Jina

    2009-01-01

    Objective: The main purpose of this paper is to use the Brassard and Donovan [Brassard, M. R. & Donovan, K. L. (2006). "Defining psychological maltreatment." In M. M. Freerick, J. F. Knutson, P. K. Trickett, & S. M. Flanzer (Eds.), "Child abuse and neglect: Definitions, classifications, and a framework for research" (pp. 151-197). Baltimore, MD:…

  3. Bachelor of Social Work (BSW) Students' Prior Sexual Abuse Victimization

    Science.gov (United States)

    Gore, Michele T.; Black, Pamela J.

    2009-01-01

    This paper reports findings of an exploratory study surveying 61 students about their prior child sexual abuse victimization. Bachelor of Social Work (BSW) students were surveyed at the beginning and end of a child abuse course and results indicated that 19.7 % of the students reported being sexually abused during childhood. Results also indicated…

  4. Child Abuse Reporting: Teachers' Perceived Deterrents.

    Science.gov (United States)

    Kenny, Maureen C.

    2001-01-01

    A survey of 197 teachers found 73 percent had never made a report of child abuse. Eleven percent reported instances in which they believed abuse may have occurred but failed to report due to such reasons as fear of making an inaccurate report, feeling that child protective services do not help families, and lacking physical signs of abuse.…

  5. Renal failure

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009221 Nephroprotective effects of subcapsular transplantation of metanephric mesenchymal cells on acute tubular necrosis rats.CHEN DAN(陈丹),et al.Div of Pediatr Nephrol,Dept Pediatr,2nd Xiangya Hosp Central South Univ,Changsha 410011,Chin J Nephrol,2009;25(3):191-197.

  6. Light-ion-induced multifragmentation. A fast, evolutionary process

    Energy Technology Data Exchange (ETDEWEB)

    Viola, V.E.; Bracken, D.S.; Foxford, E.R.; Ginger, D.; Kwiatkowski, K.; Morley, K.B.; Hsi, W.C.; Wang, G. [Indiana Univ., Bloomington, IN (United States). Dept. of Chemistry; Korteling, R.G. [Simon Fraser Univ., Burnaby, BC (Canada). Dept. of Chemistry; Legrain, R. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l`Instrumentation Associee] [and others

    1996-09-01

    GeV light-ion-induced reactions offer a unique tool for preparing hot, dilute nuclear matter. Time evolution of nuclear multifragmentation in {sup 3}He + {sup nat}Ag and {sup 3}He + {sup 197}Au reactions are investigated. Fragment-fragment correlations are studied in order to gain information on multifragmentation mechanism. (K.A.). 15 refs.

  7. Signals mediating Klotho-induced neuroprotection in hippocampal neuronal cells.

    Science.gov (United States)

    Cheng, Meng-Fu; Chen, Li-Jen; Niu, Ho-Shan; Yang, Ting-Ting; Lin, Kao-Chang; Cheng, Juei-Tang

    2015-01-01

    The erythropoietin (Epo) receptor (EpoR) is expressed in the brain and was shown to have neuroprotective effects against brain damage in animal models. A recent study indicated that EpoR and its activity are the downstream effectors of Klotho for cytoprotection in the kidney. Thus, we propose that Klotho can stimulate the expression of EpoR in neuronal cells to enhance Epo-mediated protection. H19-7 hippocampal neuronal cells were treated with recombinant Klotho. In H19-7 cells, Klotho increased the expression of both the EpoR protein and mRNA. Klotho also enhanced the transcription activity of the EpoR promoter in H19-7 cells. Moreover, Klotho augmented the Epo-triggered phosphorylation of Jak2 and Stat5 and protected H19-7 cells from hydrogen peroxide cytotoxicity. The silencing of EpoR abolished the protective effect of Klotho against peroxide-induced cytotoxicity. Finally, the silencing of GATA1 diminished the Klotho-induced increase in EpoR protein and mRNA expression as well as its promoter activity. In conclusion, Klotho increased EpoR expression in neuronal cells through GATA1, thereby enabling EpoR to function as a cytoprotective protein against oxidative injury. PMID:25856523

  8. Crisis, Kuhn, Fuller

    DEFF Research Database (Denmark)

    Jensen, Hans Siggaard

    2003-01-01

    Social Epistemology 17(2):197?201. 2003 Short description: In this paper Hans Siggaard Jensen looks at the concept of crisis as a central aspect of Kuhn?s theory of science, and relate it to Steve Fullers account of this theory as itself exemplary?not to say paradigmatic?for the understanding of...

  9. Personal Learning Environment on a Procrustean Bed – Using PLEM in a Secondary-School Lesson

    NARCIS (Netherlands)

    Verpoorten, Dominique; Chatti, Amine; Westera, Wim; Specht, Marcus

    2010-01-01

    Verpoorten, D., Chatti, M., Westera, W., & Specht, M. (2010). Personal Learning Environment on a Procrustean Bed – Using PLEM in a Secondary-School Lesson. In C. A. Shoniregun, & G. A. Akmayeva (Eds.), Proceedings of the London International Conference on Education (LICE-2010) (pp. 197-203). London,

  10. Efficiency of the Technology Acceptance Model to Explain Pre-Service Teachers' Intention to Use Technology: A Turkish Study

    Science.gov (United States)

    Teo, Timothy; Ursavas, Omer Faruk; Bahcekapili, Ekrem

    2011-01-01

    Purpose: The purpose of this study is to assess the efficiency of the technology acceptance model (TAM) to explain pre-service teachers' intention to use technology in Turkey. Design/methodology/approach: A total of 197 pre-service teachers from a Turkish university completed a survey questionnaire measuring their responses to four constructs…

  11. Comparison of single and boosted protease inhibitor versus nonnucleoside reverse transcriptase inhibitor-containing cART regimens in antiretroviral-naïve patients starting cART after January 1, 2000

    DEFF Research Database (Denmark)

    Mocroft, A; Horban, A; Clumeck, N;

    2006-01-01

    increase) response in antiretroviral-naïve patients starting either a single protease inhibitor (PI; n = 183), a ritonavir-boosted PI regimen (n = 197), or a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based cART regimen (n = 447) after January 1, 2000, and the odds of lack of virologic or...

  12. Paternity testing with VNTR DNA systems. I. Matching criteria and population frequencies of the VNTR systems D2S44, D5S43, D7S21, D7S22, and D12S11 in Danes

    DEFF Research Database (Denmark)

    Morling, N; Hansen, Hanna Elsebeth

    1993-01-01

    of the putative father as an exclusion in paternity testing. This matching criterion was used for the comparisons of 1,197 DNA fragment differences in 247 pairs of children and putative fathers who had not been excluded by conventional marker systems. In all of these cases, the migration differences between...

  13. Gclust Server: 197120 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 197120 Bja_bll4207 Cluster Sequences - 345 hypothetical protein 1 1.00e-99 0.0 0.0 0.0 0.0 3.23 0.0 Show 197...120 Cluster ID 197120 Sequence ID Bja_bll4207 Link to cluster sequences Cluster Seq

  14. Gclust Server: 197185 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 197185 Bja_bll4256 Cluster Sequences - 263 hypothetical protein 1 1.00e-99 0.0 0.0 0.0 0.0 3.23 0.0 Show 197...185 Cluster ID 197185 Sequence ID Bja_bll4256 Link to cluster sequences Cluster Seq

  15. Brief Report: Understanding Intention to Be Physically Active and Physical Activity Behaviour in Adolescents from a Low Socio-Economic Status Background: An Application of the Theory of Planned Behaviour

    Science.gov (United States)

    Duncan, Michael J.; Rivis, Amanda; Jordan, Caroline

    2012-01-01

    The aim of this brief report is to report on the utility of the Theory of Planned Behaviour (TPB) for predicting the physical activity intentions and behaviour of British adolescents from lower-than-average socio-economic backgrounds. A prospective questionnaire design was employed with 197, 13-14 year olds (76 males, 121 females). At time 1…

  16. Calcium Nutrition Perceptions among Food Bank Users: A Canadian Case Study

    Science.gov (United States)

    Johnson, Shanthi; Hawkins, Nicki

    2010-01-01

    The present study examined the differences in the food bank users' perceptions related to calcium nutrition across sex and employment status using a cross-sectional, prospective design at a large food bank in Canada. A total of 197 individuals participated for a response rate of 97%. A structured survey was developed and pilot tested before it was…

  17. Beyond Situational Ambiguity in Peer Conflict: Unique and Combined Effects of Cues from an Antagonist and a Best Friend

    Science.gov (United States)

    Smith-Schrandt, Heather L.; Ojanen, Tiina; Gesten, Ellis; Feldman, Marissa A.; Calhoun, Casey D.

    2011-01-01

    In accord with increasing recognition of the situation specificity of childhood social behaviors, individual and contextual differences in children's responses to potential peer conflict were examined (hostile attribution, behavioral strategies, and affective reactions; N = 367, 9-2 years, 197 girls). Situational cues from 2 sources, the…

  18. White Racial Identity Statuses as Predictors of White Privilege Awareness

    Science.gov (United States)

    Hays, Danica G.; Chang, Catherine Y.; Havice, Pamela

    2008-01-01

    This study explored the relationship between White privilege awareness and White racial identity development for 197 counseling trainees. Results indicated that 3 of J. E. Helms's (1984, 1990, 1995) White racial identity statuses (i.e., Contact, Reintegration, and Immersion/Emersian) significantly predicted White privilege awareness. Implications…

  19. Maine Bouguer Gravity Grid

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A 2 kilometer Bouguer anomaly grid for the state of Maine. Number of columns is 197 and number of rows is 292. The order of the data is from the lower left to the...

  20. Revision of the Lauraceae I

    NARCIS (Netherlands)

    Kostermans, A.J.G.H.

    1936-01-01

    Acrodiclidium Nees, Laur. Disp. Progr. (1833), p. 13; id., Syst. Laur. (1836), p. 266; Endl., Gen. (1837), p. 319, n. 2042; id., Ench. (1841), p. 197; Dietrich, Synops. Pl. II (1840), p. 1332; Spach, Hist. nat. Véget., Phaner. X (1841), p. 471; Steudel. Nomencl. ed. 2 (1841), p. 21; Meissn., Gen. I

  1. Revision of the Lauraceae II. The genera Endlicheria, Cryptocarya (American species) and Licaria

    NARCIS (Netherlands)

    Kostermans, A.J.G.H.

    1937-01-01

    Endlicheria Nees (non Presl) in Linnaea 8 (1833), p. 37; id., Progr. (1833), p. 16; id., Syst. (1836), p. 365; Endl., Gen. (1837), p. 321; id., Ench. (1841), p. 197; Dietrich, Synops. Pl. 2 (1840), p. 1332, 1350; Spach, Hist. nat. Végét. X (1841), p. 473; Steudel, Nomencl. ed. 2 (1841), p. 554; Meis

  2. Brief Report: Excessive Alcohol Use Negatively Affects the Course of Adolescent Depression--One Year Naturalistic Follow-Up Study

    Science.gov (United States)

    Meririnne, Esa; Kiviruusu, Olli; Karlsson, Linnea; Pelkonen, Mirjami; Ruuttu, Titta; Tuisku, Virpi; Marttunen, Mauri

    2010-01-01

    The impact of alcohol use on the course of adolescent depression over one-year was investigated by following 197 consecutive adolescent outpatients with unipolar depression in a naturalistic treatment setting. Their baseline alcohol consumption was categorized in three groups: excessive use (defined as weekly drunkenness), regular use (monthly…

  3. Gamma-activation analyses of 187 Os in molybdenite

    International Nuclear Information System (INIS)

    197Os and 187Re are used in cosmological studies. Common registration of gamma and X-ray irradiation in compositions containing these radioisotopes permits to increase the accuracy in determination of their content. The results of 187Os gamma-activation analysis in molybdenite are presented

  4. Effect of chronic, nightly hypoxia on growth and yield of channel x blue hybrid catfish

    Science.gov (United States)

    Performance traits and metabolic responses of the channel x blue hybrid catfish (Ictalurus punctatus female, Jubilee strain x I. furcatus male, D&B strain) in response to chronic nightly hypoxia were evaluated in this 197-d study. Sixteen 0.25-acre earthen ponds were stocked with 6,141 hybrid catfis...

  5. Literatura Chicana. A Comprehensive Bibliography (1980-June, 1984). Working Bibliography Series No. 1.

    Science.gov (United States)

    Trujillo, Roberto G.; And Others

    The 197-item bibliography on Chicano literature published from 1980 through June 1984 is presented in 10 sections: poetry (77 entries), novel (25 entries), short fiction (13 entries), theatre (7 entries), literary criticism (16 entries), anthology (24 entries), unpublished dissertations (13 entries), bibliographies and encyclopedia (6 entries),…

  6. Birth weight and systolic blood pressure in adolescence and adulthood

    DEFF Research Database (Denmark)

    Gamborg, Michael; Byberg, Liisa; Rasmussen, Finn;

    2007-01-01

    The authors investigated the shape, sex- and age-dependency, and possible confounding of the association between birth weight and systolic blood pressure (SBP) in 197,954 adults from 20 Nordic cohorts (birth years 1910-1987), one of which included 166,249 Swedish male conscripts. Random...

  7. Disease: H00396 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available am Pract 55:500-2 (2006) PMID:21120728 MacDonald N, Hatchette T, Elkout L, Sarwal S Mumps is back: why is mumps eradication not worki...ng? Adv Exp Med Biol 697:197-220 (2011) PMID:19815120 (d

  8. Do Cs Make Degrees? The Relationship of Maximizing versus Satisficing Student Types and Academic Success in the Business Curriculum

    Science.gov (United States)

    Stohs, Mark Hoven

    2016-01-01

    The author analyzed the academic performance of 197 business students in their first required finance course. He postulated that the students' performance related to whether their academic strategy was one of two types: satisficing or maximizing. Satisficers seemed content with getting Cs to earn their degree, while maximizers aimed for the…

  9. Clinical Evaluation of the Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test for Rapid Diagnosis of Tuberculosis Lymphadenitis

    OpenAIRE

    Kerleguer, A.; Fabre, M.; Bernatas, J. J.; Gerome, P.; E. Nicand; Herve, V; Koeck, J.L.

    2004-01-01

    This prospective study evaluated the performance of the Amplified Mycobacterium Tuberculosis Direct Test (MTD) for the diagnosis of lymph node tuberculosis in Djibouti, Republic of Djibouti. Of 197 specimens sampled from 153 patients, 123 were from 95 tuberculous patients. The sensitivity and specificity of MTD were 93 and 100%, respectively. The sensitivity of culture was 89%.

  10. Clinical Observed Performance Evaluation: A Prospective Study in Final Year Students of Surgery

    Science.gov (United States)

    Markey, G. C.; Browne, K.; Hunter, K.; Hill, A. D.

    2011-01-01

    We report a prospective study of clinical observed performance evaluation (COPE) for 197 medical students in the pre-qualification year of clinical education. Psychometric quality was the main endpoint. Students were assessed in groups of 5 in 40-min patient encounters, with each student the focus of evaluation for 8 min. Each student had a series…

  11. AcEST: BP914229 [AcEST

    Lifescience Database Archive (English)

    Full Text Available tin synthase regulatory factor 3 OS=Schi... 36 0.099 sp|Q9ZG88|PODJ_CAUCR Localization factor podJL OS=Caulo...SSIVKAV 197 +A + + AA GH + Y +A+CLQ G GV K V Sbjct: 661 KAFELYSLAAKKGHPLSNYRVAVCLQTGTGVKPDTSKCV 699 >sp|Q9ZG88|PODJ_CAUCR Local

  12. Villa Lokaator Paldiskis = Villa Locator in Paldiski

    Index Scriptorium Estoniae

    2008-01-01

    Vana sõjaväebaraki varemetele ehitatud villa (197 m2) pälvis peapreemia Eesti Arhitektide Liidu konkursil "Eramu 2006-2007". Arhitektid: Siiri Vallner, Indrek Peil. Projektbüroo: Head Arhitektid. Sisearhitektuur: arhitektid ja omanikud. Valmis: 2007. 2 plaani, 8 värv. välisvaadet, sisevaade

  13. Current trends of some organochlorinated pesticides in Yamuna River sediments around Delhi

    Digital Repository Service at National Institute of Oceanography (India)

    Sethi, P.K.; Bhattacharyya, A.K.; Sarkar, A.

    considerably during the monsoon (38.0-197.7 ng/g) and post-monsoon (18.4-26.8 ng/g) periods respectively. Najafgarh site was found to be carrying the maximum load of pollutants, exceeding the permissible limits...

  14. 78 FR 1848 - Intent To Grant an Exclusive License of a U.S. Government-Owned Invention

    Science.gov (United States)

    2013-01-09

    ... license to the invention claimed in U.S. Patent No. 6,316,197, entitled ``Method of Diagnosing of Exposure... of business at 4938 Hampden Lane 319, Bethesda, Maryland 20814-2914. ADDRESSES: Commander, U.S. Army Medical Research and Materiel Command, ATTN: Command Judge Advocate, MCMR-JA, 504 Scott Street,...

  15. A Comparison of the Number of Hours of Sleep in High School Students Who Took Advanced Placement and/or College Courses and Those Who Did Not

    Science.gov (United States)

    Jin, Qiushuang; Shi, Qian

    2008-01-01

    This study investigated the association between sleep deprivation and enrollment in Advanced Placement (AP) and/or college courses among high school students. Approximately 4,000 surveys were distributed, and 2,197 completed surveys were returned from students in Grades 9 to 12 at 15 high schools in Iowa. Findings indicated the majority of high…

  16. An Investigation of Prior Sources of Difficulties in Learning University Computer Science.

    Science.gov (United States)

    Dixon, Victoria A.

    The background of 197 university students from four introductory computer science classes at the State University of New York at Buffalo was investigated to determine factors contributing to academic success or failure in computer science. A background questionnaire, a test of computer science concepts (reading a simple program, symbol…

  17. Employment-Related Experiences of Youths Who Are Visually Impaired: How Are These Youths Faring?

    Science.gov (United States)

    Shaw, Alexander; Gold, Deborah; Wolffe, Karen

    2007-01-01

    This article describes the results in the employment domain of a larger study of the lifestyles of 328 Canadian youths, aged 15-21 and 22-30, 131 of whom were blind and 197 of whom had low vision. The youths completed a survey on their work-related experiences, including their current employment status and job-search strategies. In addition to…

  18. Response of channel x blue hybrid catfish to chronic diurnal hypoxia

    Science.gov (United States)

    Performance traits and metabolic responses of the channel x blue hybrid catfish (Ictalurus punctatus female x I. furcatus male) in response to chronic diurnal hypoxia were evaluated in this 197-d study. Sixteen 0.1-ha earthen ponds were stocked with 15,169 hybrid catfish/ha (47 g/fish) and managed t...

  19. Emission patterns of neutral pions in 40A MeV Ta plus Au reactions

    NARCIS (Netherlands)

    Piasecki, K.; Matulewicz, T.; Yahlali, N.; Delagrange, H.; Diaz, J.; d'Enterria, D. G.; Fernandez, F.; Kugler, A.; Löhner, H.; Martinez-Garcia, G.; Ostendorf, R. W.; Schutz, Y.; Tlusty, P.; Turrisi, R.; Wagner, V.; Wilschut, H. W.

    2010-01-01

    Differential cross sections of neutral pions emitted in (181)Ta+(197)Au collisions at a beam energy of 39.5A Me V have been measured with the two-arm photon spectrometer (TAPS). The kinetic energy and transverse momentum spectra of neutral pions cannot be properly described in the framework of the t

  20. Experiment list: SRX142525 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Cruz Biotech || antibody vendorid=sc-197 || control=Control_50bp || control description=This data represents a control being compare...on=Immortal cells || control=Control_50bp || control description=This data represents a control being compared

  1. Workplace Learning and Generation X.

    Science.gov (United States)

    Bova, Breda; Kroth, Michael

    2001-01-01

    A survey of the learning preferences of 197 Generation X workers found that they value incidental and action learning. They recognized the need for formal training, but suggested improvements. They preferred learning by doing, visual stimuli, and self-directed learning. (Contains 26 references.) (SK)

  2. Eesti viimane kolhoos pelgab tulevikku / Anne Oja ; kommenteerinud Vallo Visnapuu, Argo Mättas, Mart Vaiksaar ... [jt.

    Index Scriptorium Estoniae

    Oja, Anne, 1970-

    2011-01-01

    Vändra katsesovhoosi jagunemisel loodud OÜ Selja nõukogu ja juhatus on otsustanud firma maha müüa, kuigi enamik ettevõtte 197-st eraisikust osanikust on selle vastu. Võimalikud ostjad on Trigon Farming AS või Jõgeva Põllumajandustootjate Liit (JPL)

  3. 33 CFR 230.3 - References.

    Science.gov (United States)

    2010-07-01

    ... Department of Defense Actions; Policies and Procedures 32 CFR part 197 (44 FR 21786-92, April 12, 1979). (f... Environmental Policy Act of 1969,” (40 CFR parts 1500 through 1508, November 29, 1978), Council on Environmental... Implementation Studies (48 CFR parts 10249 through 10258, March 10, 1983). (k) Regulatory Programs of the...

  4. The contact polytope of the Leech lattice

    OpenAIRE

    Dutour Sikiric, M.; Schuermann, A.; Vallentin, Frank

    2010-01-01

    The contact polytope of a lattice is the convex hull of its shortest vectors. In this paper we classify the facets of the contact polytope of the Leech lattice up to symmetry. There are 1, 197, 362, 269, 604, 214, 277, 200 many facets in 232 orbits.

  5. Tracking drinking behaviour from age 15-19 years

    DEFF Research Database (Denmark)

    Andersen, Anette; Due, Pernille; Holstein, Bjørn E;

    2003-01-01

    .44, confidence interval (CI): 1.38-4.29, respectively, OR = 1.97, CI: 1.15-3.38]. CONCLUSIONS: Alcohol consumption as early as the age of 15 predicted weekly alcohol consumption and alcohol intake exceeding the recommended amount 4 years later. Young teenagers' high alcohol consumption was not just a passing...

  6. Teraviljakasvatus : [Eestis 2003-2004] / Elsa Nurk

    Index Scriptorium Estoniae

    Nurk, Elsa

    2005-01-01

    Ilmunud ka: Agriculture and the development of rural life : overview 2004/2005. - Tallinn, 2005, lk. 31-34. Koristatud teraviljasaaak 2004. a. oli 599,7 tuhat tonni, millest 19,7 tuhat tonni oli rukist, 184,7 tuhat tonni nisu ja 289,5 tuhat tonni otra. Tabel

  7. Uuenenud "ARCOmadrid" / Mary-Ann Talvistu

    Index Scriptorium Estoniae

    Talvistu, Mary-Ann

    2011-01-01

    Madridis 16.-20.02.2011 toimunud rahvusvahelisest kaasaegse kunsti messist "ARCOmadrid". Osales 197 galeriid, külalismaana oli kutsutud Venemaa. Hispaania Kunstikriitikute Assotsiatsiooni preemia pälvis Ángela de la Cruz parima rahvusvahelise kunstniku kategoorias ja Juan Genovés parima hispaanlasest kunstniku kategoorias

  8. Oxidation mechanisms in real food emulsions : Method for separation of mayonnaise by ultracentrifugation

    DEFF Research Database (Denmark)

    Jacobsen, Charlotte; Meyer, Anne S.; Adler-Nissen, Jens

    1998-01-01

    With the aim of studying partition coefficients of antioxidants and secondary oxidation products in a real food emulsion a method,for the separation of mayonnaise was developed. The method included freezing and a mild precentrifugation step followed by ultracentrifugation at 197,500 x g...

  9. The Stability and Reliability of a Modified Work Components Study Questionnaire in the Educational Organization.

    Science.gov (United States)

    Miskel, Cecil; Heller, Leonard E.

    The investigation attempted to establish the factorial validity and reliability of an industrial selection device based on Herzberg's theory of work motivation related to the school organization. The questionnaire was reworded to reflect an educational work situation; and a random sample of 197 students, 118 administrators, and 432 teachers was…

  10. Satisfying Friendship Maintenance Expectations: The Role of Friendship Standards and Biological Sex

    Science.gov (United States)

    Hall, Jeffrey A.; Larson, Kiley A.; Watts, Amber

    2011-01-01

    The ideal standards model predicts linear relationship among friendship standards, expectation fulfillment, and relationship satisfaction. Using a diary method, 197 participants reported on expectation fulfillment in interactions with one best, one close, and one casual friend (N = 591) over five days (2,388 interactions). Using multilevel…

  11. Calculation of self-shielding coefficients, flux depression and cadmium factor for thermal neutron flux measurement of the IPEN/MB-01 reactor

    International Nuclear Information System (INIS)

    A calculation methodology of Flux Depression, Self-Shielding and Cadmium Factors is presented, using the ANISN code, for experiments conducted at the IPEN/MB-01 Research Reactor. The correction factors were determined considering thermal neutron flux and 0.125 e 0.250 mm diameter of 197 Au wires. (author)

  12. ISOLDE target zone control room

    CERN Multimedia

    2016-01-01

    Operating the ISOLDE target handling robots from the dedicated control room in building 197. Monitors showing the movements of the robots (GPS in this case) in the target zone. The footage shows the actual operation by the operator as well as the different equipment such as camera electronics, camera motor controls, camera monitors and Kuka robot controls touch panel.

  13. ISOLDE target zone control room HD

    CERN Document Server

    2016-01-01

    Operating the ISOLDE target handling robots from the dedicated control room in building 197. Monitors showing the movements of the robots (GPS in this case) in the target zone. The footage shows the actual operation by the operator as well as the different equipment such as camera electronics, camera motor controls, camera monitors and Kuka robot controls touch panel.

  14. Premature sperm activation and defective spermatogenesis caused by loss of spe-46 function in Caenorhabditis elegans.

    Directory of Open Access Journals (Sweden)

    Wei-Siang Liau

    Full Text Available Given limited resources for motility, sperm cell activation must be precisely timed to ensure the greatest likelihood of fertilization. Like those of most species, the sperm of C. elegans become active only after encountering an external signaling molecule. Activation coincides with spermiogenesis, the final step in spermatogenesis, when the spherical spermatid undergoes wholesale reorganization to produce a pseudopod. Here, we describe a gene involved in sperm activation, spe-46. This gene was identified in a suppressor screen of spe-27(it132ts, a sperm-expressed gene whose product functions in the transduction of the spermatid activation signal. While spe-27(it132ts worms are sterile at 25°C, the spe-46(hc197I; spe-27(it132tsIV double mutants regain partial fertility. Single nucleotide polymorphism mapping, whole genome sequencing, and transformation rescue were employed to identify the spe-46 coding sequence. It encodes a protein with seven predicted transmembrane domains but with no other predicted functional domains or homology outside of nematodes. Expression is limited to spermatogenic tissue, and a transcriptional GFP fusion shows expression corresponds with the onset of the pachytene stage of meiosis. The spe-46(hc197 mutation bypasses the need for the activation signal; mutant sperm activate prematurely without an activation signal in males, and mutant males are sterile. In an otherwise wild-type genome, the spe-46(hc197 mutation induces a sperm defective phenotype. In addition to premature activation, spe-46(hc197 sperm exhibit numerous defects including aneuploidy, vacuolization, protruding spikes, and precocious fusion of membranous organelles. Hemizygous worms [spe-46(hc197/mnDf111] are effectively sterile. Thus, spe-46 appears to be involved in the regulation of spermatid activation during spermiogenesis, with the null phenotype being an absence of functional sperm and hypomorphic phenotypes being premature spermatid activation

  15. 中国本土割手密血缘创新亲本材料的利用潜力分析%Breeding Potential of Creation Parents Derived from China Native Saccharum spontaneum in Sugarcane

    Institute of Scientific and Technical Information of China (English)

    朱建荣; 桃联安; 董立华; 周清明; 段惠芬; 杨李和; 安汝东; 刘洪博; 经艳芬

    2011-01-01

    The parents derived from China native Saccharum spontaneum Yunge F1, F2, Yacheng 71 - 374 (F2 ) and some of their progenies were crossed to commonly used parents, thirty cross combinations were made to study the hereditary effects of main trait.The results indicated the effects on offspring by male, female and combination were extremely significantly different ( P < 0.01).The contribution sequence of broad-sense heritability on offspring populations was cross combination (89.6% ) >male (76.4% ) > female (70.6% ) , sequence of broad-sense heritability for main traits was brix > millable stalk > diameter > plant height > cane yield > sugar yield.Among all the creation parentsderived from 5.spontaneum, genotypes as followings were parents with high general combining ability (GCA), YungeF197 - 105, YungeF197 - 147, YungeF203-7, YungeF203 - 78, YungeF180 -189, Yunrui05-458 and Yunge F203 -72 could be excellent female parents, Yunzhe99 - 155, YungeF203 -315, Yunzhe89 -7, Guitang92 -66, Neijiang00 - 118 could be excellent parents for improving sugar content, the cross combinations Dezhe93 - 88 × YungeF203 -7, CP65 -357 × YungeF180 - 189 and Yuetang93 - 159 × YungeF180 - 189 could be potential for improving sugar yield and cane yield.And CP65 - 357 × YungeF197 - 105, Yuetang93 - 159 × YungeF197 - 147, Yun-rui05 -344 ×YungeF197 - 105, Q141 × YungeF197 - 105, Yunrui05 - 189 × YungeF203 - 78, Yunrui05 -344 × Yunrui05 -458 and Nonglin03 -1× YungeF197 - 105 could be potential for breeding genotypes with high cane yield and high biomass.%以云割F1,F2崖城71-374(F2)及其后代与国内外常用亲本配成的30个杂交组合为研究材料,分析其有性世代主要性状的遗传效应.结果表明:母本、父本及选配方式的不同后代的主要性状均表现极显著差异(P父本(76.4%)>母本(70.6%);后代主要性状的遗传力大小顺序为锤度>有效茎>茎径>株高>蔗产量>糖产量;云割F197-105,云割F197-147,

  16. Immuno-vectorization of radioelements emitters of alpha particles: a new therapy in cancerology

    International Nuclear Information System (INIS)

    The radio-immunotherapy is an anti cancerous therapy which consists in vectorising with immuno-specific agents very radio toxic radioelements on tumors or in their environment to destroy them. The first part of this report presents the different characteristics of antibodies as well as their means of production under monoclonal shapes specifically steered against a tumoral antigen of interest. The second part of this report replaces the importance of the immunological vectors in the context of the nuclear medicine. It is notably described that the different methods which allow to radio-label the vector, as well as the different ways of optimization which were envisaged to improve the targeting of radioelements on a tumor. These different developments allow to define the potential place of the alpha radio-immunotherapy in treatments and so re-place the interest of the experimental part. If the radio-immunotherapy, using beta emitters isotopes as the 131iodine or the90yttrium, is today current in anti cancerous therapy, it finds limits because of the disintegration characteristics of the isotopes it uses. Indeed, compared with alpha particles, the beta particles deposit less energy by unit of length in the crossed material.The experimental part of this report aims at studying the feasibility of the coupling between an immunological vector and an alpha emitter isotope.The different tests led on the bismuth 213, the bismuth 212, the lead 212 and the astatine 211 demonstrated that the fixation of these radionuclides was possible. This research theme is strengthened by the construction in Nantes of a cyclotron with high energy ( A.R.R.O.N.A.X.) and the optimization of the obtained promising results should allow a therapeutic use in oncology of the alpha radio-immunotherapy. (N.C.)

  17. Immuno-vectorization of radioelements emitters of alpha particles: a new therapy in cancerology; Immunovectorisation de radioelements emetteurs de particules alpha: une nouvelle voie therapeutique en cancerologie

    Energy Technology Data Exchange (ETDEWEB)

    Bourgeois, M

    2007-05-15

    The radio-immunotherapy is an anti cancerous therapy which consists in vectorising with immuno-specific agents very radio toxic radioelements on tumors or in their environment to destroy them. The first part of this report presents the different characteristics of antibodies as well as their means of production under monoclonal shapes specifically steered against a tumoral antigen of interest. The second part of this report replaces the importance of the immunological vectors in the context of the nuclear medicine. It is notably described that the different methods which allow to radio-label the vector, as well as the different ways of optimization which were envisaged to improve the targeting of radioelements on a tumor. These different developments allow to define the potential place of the alpha radio-immunotherapy in treatments and so re-place the interest of the experimental part. If the radio-immunotherapy, using beta emitters isotopes as the {sup 131}iodine or the{sup 90}yttrium, is today current in anti cancerous therapy, it finds limits because of the disintegration characteristics of the isotopes it uses. Indeed, compared with alpha particles, the beta particles deposit less energy by unit of length in the crossed material.The experimental part of this report aims at studying the feasibility of the coupling between an immunological vector and an alpha emitter isotope.The different tests led on the bismuth 213, the bismuth 212, the lead 212 and the astatine 211 demonstrated that the fixation of these radionuclides was possible. This research theme is strengthened by the construction in Nantes of a cyclotron with high energy ( A.R.R.O.N.A.X.) and the optimization of the obtained promising results should allow a therapeutic use in oncology of the alpha radio-immunotherapy. (N.C.)

  18. Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp transcription factors by targeting microRNAs

    Directory of Open Access Journals (Sweden)

    Gandhy Shruti U

    2012-11-01

    Full Text Available Abstract Background Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp transcription factors Sp1, Sp3 and Sp4 and pro-oncogenic Sp-regulated genes. In this study, we investigated the anticancer activity of curcumin and several synthetic cyclohexanone and piperidine analogs in colon cancer cells. Methods The effects of curcumin and synthetic analogs on colon cancer cell proliferation and apoptosis were determined using standardized assays. The changes in Sp proteins and Sp-regulated gene products were analysed by western blots, and real time PCR was used to determine microRNA-27a (miR-27a, miR-20a, miR-17-5p and ZBTB10 and ZBTB4 mRNA expression. Results The IC50 (half-maximal values for growth inhibition (24 hr of colon cancer cells by curcumin and synthetic cyclohexanone and piperidine analogs of curcumin varied from 10 μM for curcumin to 0.7 μM for the most active synthetic piperidine analog RL197, which was used along with curcumin as model agents in this study. Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR, hepatocyte growth factor receptor (c-MET, survivin, bcl-2, cyclin D1 and NFκB (p65 and p50. Curcumin and RL197 also induced reactive oxygen species (ROS, and cotreatment with the antioxidant glutathione significantly attenuated curcumin- and RL197-induced growth inhibition and downregulation of Sp1, Sp3, Sp4 and Sp-regulated genes. The mechanism of curcumin-/RL197-induced repression of Sp transcription factors was ROS-dependent and due to induction of the Sp repressors ZBTB10 and ZBTB4 and downregulation of microRNAs (miR-27a, miR-20a and miR-17-5p that regulate these repressors

  19. The ASY-EOS experiment at GSI: investigating the symmetry energy at supra-saturation densities

    CERN Document Server

    Russotto, P; De Filippo, E; Févre, A Le; Gannon, S; Gašparić, I; Kiš, M; Kupny, S; Leifels, Y; Lemmon, R C; Łukasik, J; Marini, P; Pagano, A; Pawłowski, P; Santoro, S; Trautmann, W; Veselsky, M; Acosta, L; Adamczyk, M; Al-Ajlan, A; Al-Garawi, M; Al-Homaidhi, S; Amorini, F; Auditore, L; Aumann, T; Ayyad, Y; Baran, V; Basrak, Z; Benlliure, J; Boiano, C; Boisjoli, M; Boretzky, K; Brzychczyk, J; Budzanowski, A; Cardella, G; Cammarata, P; Chajecki, Z; Chbihi, A; Colonna, M; Cozma, D; Czech, B; Di Toro, M; Famiano, M; Geraci, E; Greco, V; Grassi, L; Guazzoni, C; Guazzoni, P; Heil, M; Heilborn, L; Introzzi, R; Isobe, T; Kezzar, K; Krasznahorkay, A; Kurz, N; La Guidara, E; Lanzalone, G; Lasko, P; Li, Q; Lombardo, I; Lynch, W G; Matthews, Z; May, L; Minniti, T; Mostazo, M; Papa, M; Pirrone, S; Politi, G; Porto, F; Reifarth, R; Reisdorf, W; Riccio, F; Rizzo, F; Rosato, E; Rossi, D; Simon, H; Skwirczynska, I; Sosin, Z; Stuhl, L; Trifiró, A; Trimarchi, M; Tsang, M B; Verde, G; Vigilante, M; Wieloch, A; Wigg, P; Wolter, H H; Wu, P; Yennello, S; Zambon, P; Zetta, L; Zoric, M

    2012-01-01

    The elliptic-flow ratio of neutrons with respect to protons in reactions of neutron rich heavy-ions systems at intermediate energies has been proposed as an observable sensitive to the strength of the symmetry term in the nuclear Equation Of State (EOS) at supra-saturation densities. The recent results obtained from the existing FOPI/LAND data for $^{197}$Au+$^{197}$Au collisions at 400 MeV/nucleon in comparison with the UrQMD model allowed a first estimate of the symmetry term of the EOS but suffer from a considerable statistical uncertainty. In order to obtain an improved data set for Au+Au collisions and to extend the study to other systems, a new experiment was carried out at the GSI laboratory by the ASY-EOS collaboration in May 2011.

  20. Effects of the initialization of nucleon momentum on isospin-sensitive observables

    CERN Document Server

    Zhang, Fang

    2016-01-01

    Based on the Isospin-dependent transport model Boltzmann-Uehling-Uhlenbeck (IBUU), effects of the high momentum tail (HMT) of nucleon initial momentum distribution in colliding nuclei on some isospin-sensitive observables are studied in the semi-central $^{197}\\rm {Au}+^{197}\\rm {Au}$ reactions at incident beam energy of 400 MeV/nucleon. It is found that the nucleon transverse flow, the difference of neutron and proton transverse flows, the nucleon elliptic flow and free neutron to proton ratio are all less sensitive to the HMT, while the isospin-sensitive nucleon elliptic flow difference is clearly affected by the HMT. Except at very high kinetic energies, the kinetic energy distributions of $\\pi^{-}$, $\\pi^{+}$ and charged pion ratio $\\pi^{-}/\\pi^{+}$ are all sensitive to the HMT.

  1. 白细胞介素-6基因多态性与高脂血症的相关性%Association of interleukin-6 polymorphism and hyperlipemia

    Institute of Scientific and Technical Information of China (English)

    何美霞; 张明明; 刘琼; 华海婴; 巴云鹏; 张莉蓉

    2011-01-01

    目的 探讨高血脂患者白细胞介素-6(IL-6)启动子-634C/G基因多态性是否为高脂血症的遗传因素.方法 筛选高脂血症患者197例,健康志愿者200例.采用酚-氯仿法提取外周血DNA,PCR-RFLP技术检测IL-6基因多态性.结果 高脂血症组CC、CG和GG基因型的频率分别为51.3%(101/197),37.6% (74/197)和11.1% (22/197), 与正常对照组[CC:65% (130/200);CG:28.5% (57/200);GG:6.5%(13/200)]相比差异具有显著性(P<0.05).关联分析显示G等位基因是高脂血症的一个独立危险因素(OR=1.736, 95%CI=1.257~2.397).高脂血症组中,CG及GG基因型者的总胆固醇(TC)水平明显高于CC型,GG基因型高密度脂蛋白胆固醇(HDL-C)水平明显低于CC型.结论 IL-6 -634 CG及GG基因型和G等位基因携带者具有高脂血症易感性.%Objective To investigate the importance of the interleukin-6 (IL-6) gene polymorphism in Chinese population. Methods 200 healthy controls and the 197 hyperlipemia subjects were selected. DNA was extracted from peripheral blood with the method of phenol-chloroform. IL-6 gene polymorphism was screened by polymerase chain reaction-restriction fragment length polymorphism ( PCRRFLP). Results In the case subjects, the frequencies of the CC, CGand GG genotypes were51.3%(101/197), 37.6%(74/197) and 11.1% (22/197 ), respectively. There were significant differences compared with controls [ CC :65% ( 130/200 ); CG:28.5% (57/200)and GG:6. 5% (13/200) ]. G allele was one of independent risk factors for hyperlipemia ( OR = 1. 736 ;95 % CI = 1. 257 ~ 2. 397 ). GC and GG carriers showed significantly higher serum total cholesterol levels than CC carriers in hyperlipemia group. In contrast, GG carriers showed significantly lower serum high-density lipoprotein cholesterol levels than CC carriers. Conclusions CG and GG genotypes and G allele gene increase the risk of hyperlipemia.

  2. Experiments at GSI with ALADIN and INDRA

    International Nuclear Information System (INIS)

    The multi-fragment spectator decays following collisions of 197Au on 197Au and other heavy nuclei at relativistic bombarding energies have been studied by the ALADIN collaboration in recent years. The partitioning modes of the excited systems and their thermodynamic properties at breakup were in the center of interest in these experiments. Temperatures and excitation energies, but also breakup densities and emission times have been determined. More recently, the multifragmentation of highly excited heavy nuclei was studied with the 4π multidetector INDRA in experiments at the GSI in 1998 and 1999. The motivation for these new experiments was to extend the investigation of fragmentation processes and of their link to the liquid-gas phase transition to bombarding energies beyond those used in previous INDRA campaigns at GANIL. First results from the analysis of these data will be discussed with particular emphasis on topics related to previous ALADIN work. (orig.)

  3. Fiscal 1998 research report on International Clean Energy Network using Hydrogen Conversion (WE-NET). Subtask 2. Research on promotion of international cooperation (research on standardization of hydrogen energy technologies); 1998 nendo suiso riyo kokusai clean energy system gijutsu (WE-NET) sub task. 2. Kokusai kyoryoku suishin no tame no chosa kento (suiso energy gijutsu hyojunka ni kansuru chosa kento)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    This report summarizes the fiscal 1998 research result on the basic research on standardization of hydrogen energy technologies, and ISO/TC197. As for the standardization, in relation to the hydrogen station in the WE-NET second phase research, the laws related to handling of gaseous hydrogen, and the basic issues on facility and safe handling were studied. As for ISO/TC197, the following draft standards were examined: Fuel supply system interface for liquid hydrogen vehicles, fuel tank for liquid hydrogen vehicles, container for liquid hydrogen transport, specification of hydrogen fuel, hydrogen fuel supply facility for air ports, gaseous hydrogen and hydrogen mixture fuel system for vehicles, gaseous hydrogen fuel connector for vehicles, gaseous hydrogen fuel tank for vehicles, and basic items for hydrogen system safety. Final examination of the fuel supply system interface for liquid hydrogen vehicles, and the specification of hydrogen fuel was finished, and these are scheduled to be registered for ISO. (NEDO)

  4. Dependence of the cross sections for Ir isotopes on the values of Qgg in the heavy ion collision

    Institute of Scientific and Technical Information of China (English)

    YANG Wei-Fan; ZHAO Zhi-Zheng; YUAN Shuang-Gui; XU Yan-Bing; LU Xi-Ting

    2009-01-01

    197Au were irradiated with 47 MeV/u 12C ions. Iridium was produced via the multinucleon transfer reactions in bombardments of 197Au with 12C. and was separated radiochemically from Au and the mixture of the reaction products. The γ radioactivities of Ir isotopes were measured by using a HPGe detector. The production cross sections of Ir isotopes were determined from activities of Ir isotopes at the end of bombardment and the other relative data. It has been found that the cross sections for neutron-rich isotopes of iridium show an exponential dependence on the values of Qgg. Our experimental results also demonstrate lack of correlation between the cross sections and Qgg in the case of neutron-deficient isotopes of iridium. The fact can be explained from that neutron-rich isotopes of iridium were produced in the deep inelastic transfer reactions.

  5. Hydrogen Fuel Quality

    Energy Technology Data Exchange (ETDEWEB)

    Rockward, Tommy [Los Alamos National Laboratory

    2012-07-16

    For the past 6 years, open discussions and/or meetings have been held and are still on-going with OEM, Hydrogen Suppliers, other test facilities from the North America Team and International collaborators regarding experimental results, fuel clean-up cost, modeling, and analytical techniques to help determine levels of constituents for the development of an international standard for hydrogen fuel quality (ISO TC197 WG-12). Significant progress has been made. The process for the fuel standard is entering final stages as a result of the technical accomplishments. The objectives are to: (1) Determine the allowable levels of hydrogen fuel contaminants in support of the development of science-based international standards for hydrogen fuel quality (ISO TC197 WG-12); and (2) Validate the ASTM test method for determining low levels of non-hydrogen constituents.

  6. Dicty_cDB: Contig-U15692-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available s taurus ATP-binding cassette, s... 192 7e-47 U39739_1( U39739 |pid:none) Drosophila melanogaster scarlet pr... RecName: Full=Protein scarlet; &AE014296_2908(AE014296... 196 6e-48 AC146546_23( AC146546 |pid:none) Oryza ...AX320881_1( AX320881 |pid:none) Sequence 2 from Patent WO0179272. ... 197 4e-48 AY172185_1( AY172185 |pid:none) Bactrocera tryoni sca...rlet gene, co... 197 4e-48 (Q9SW08) RecName: Full=White-brown complex homolog prote...prot... 196 5e-48 AY155346_1( AY155346 |pid:none) Bactrocera cucurbitae white eye pr... 196 6e-48 ( P45843 )

  7. Fragmentation in peripheral heavy-ion collisions: from neck emission to spectator decays

    International Nuclear Information System (INIS)

    Invariant cross sections of intermediate mass fragments in peripheral collisions of 197Au on 197Au at incident energies between 40 and 150 MeV per nucleon have been measured with the 4π multi-detector INDRA. The maximum of the fragment production is located near mid-rapidity at the lower energies and moves gradually towards the projectile and target rapidities as the energy is increased. Schematic calculations within an extended Goldhaber model suggest that the observed cross-section distributions and their evolution with energy are predominantly the result of the clustering requirement for the emerging fragments and of their Coulomb repulsion from the projectile and target residues. The quantitative comparison with transverse energy spectra and fragment charge distributions emphasizes the role of hard scattered nucleons in the fragmentation process. (orig.)

  8. Activation cross sections of proton induced nuclear reactions on gold up to 65 MeV

    CERN Document Server

    Ditrói, F; Takács, S; Hermanne, A

    2016-01-01

    Activation cross sections of proton induced reactions on gold for production of $^{197m,197g,195m,195g, 193m,193g,192}$Hg, $^{196m,196g(cum),195g(cum),194,191(cum)}$Au, $^{191(cum)}$Pt and $^{192}$Ir were measured up to 65 MeV proton energy, some of them for the first time. The new data are in acceptably good agreement with the recently published earlier experimental data in the overlapping energy region. The experimental data are compared with the predictions of the TALYS 1.6 (results in TENDL-2015 on-line library) and EMPIRE 3.2 code.

  9. Dynamical approach to spectator fragmentation in Au+Au reactions at 35 MeV/A

    CERN Document Server

    Vermani, Yogesh K

    2010-01-01

    The characteristics of fragment emission in peripheral $^{197}$Au+$^{197}$Au collisions 35 MeV/A are studied using the two clusterization approaches within framework of \\emph{quantum molecular dynamics} model. Our model calculations using \\emph{minimum spanning tree} (MST) algorithm and advanced clusterization method namely \\emph{simulated annealing clusterization algorithm} (SACA) showed that fragment structure can be realized at an earlier time when spectators contribute significantly toward the fragment production even at such a low incident energy. Comparison of model predictions with experimental data reveals that SACA method can nicely reproduce the fragment charge yields and mean charge of the heaviest fragment. This reflects suitability of SACA method over conventional clusterization techniques to investigate spectator matter fragmentation in low energy domain.

  10. VLA Polarimetry of Two Extended Radio Galaxies

    CERN Document Server

    Junor, W; Morganti, R; Padrielli, L

    2000-01-01

    Multi-wavelength VLA observations of two extended radio galaxies, 0235-197and 1203+043 are presented. There is some evidence from earlier studies thatthese two sources exhibit low frequency (<1 GHz) variability. This work showsthat both sources have linear polarizations, if any, below the detection limitsat 320 MHz, so we cannot explain the variability as being due to instrumentalpolarization effects as has been suggested for 3C159. Refractive scintillationmay be the cause of the variability in 0235-197. This would require theexistence of a bright, compact component in one of the hot spots seen in theseobservations. This is not implausible but the resolution of this observationalprogram is insufficent to address that question. The radio source 1203+043lacks any bright compact component thereby ruling out a refractivescintillation mechanism for its variability. Consequently, it is possible thatclaims of variability in this source are spurious. However, the 320 MHz VLAobservations show that 1203+043 has an `...

  11. The Relationship Between Angular Distributions of Quick Ternary Fission with Impact Parameter in Heavy Nuclear Reaction%重核快三裂变反应角分布与碰撞参数的关系

    Institute of Scientific and Technical Information of China (English)

    李贤

    2015-01-01

    This paper studies the relationship Between angular distributions in quick ternary fissions with impact parameter. By comparing experimental data of angular distributions,it concludes that the quick ternary fissions are process of deep inelastic or elastic scattering and are easy to occur in intermediate and large impact parameters.%文章研究了197Au+197Au体系快三裂变反应的角分布与碰撞参数的关联性,并与实验上角分布数据做对比,结果表明该裂变是深度非弹性或准弹性散射过程,易发生在中等和大碰撞参数下。

  12. Contribution of radioisotopes in the diagnosis of lung tumours

    International Nuclear Information System (INIS)

    197Hg, a radioisotope of half life 65 h, injected as acetate builds up in malignant tumours and evolutive inflammatory lesions. In spite of a high proportion of false positives it can lead to a lung cancer diagnosis under well-defined circumstances such as: round lung images, X-ray tuberculosis images persisting after prolonged therapy, treated cancers where it can detect relapses before X-rays and in the difficult case of benign tumours. In man the uptake kinetics of carrier-free 67Cu (half-life 58 h), injected as citrate, are apparently not the same in cancers as in evolutive inflammatory lesions. The false positive yield, through much lower than that observed with 197Hg, is still too high in this preliminary study

  13. Communication of nuclear data progress: No.5 (1991)

    International Nuclear Information System (INIS)

    > (CNDP) in English is set up by chinese nuclear committee and chinese nuclear data center (CNDC). This is the fifth issue. It includes comprehensive reports (1987-1990), theoretical calculation data evaluation, data library, data processing and nuclear data news. The detail information on following problems or described: the total neutron cross sections of 27Al, 63Cu, 238U;cross section of reaction 45Sc(n, γ), 59Co, 95Mo(p, n) and Pb(n, 2n), complete sets of neutron data for V, Cr, Cu, Ni, Zr, Nb and Ti, Sn, Sb, 181Ta, 197Au, double differential cross sections of 56Fe(p, x) on reaction, average level spacings of 57Fe, 85,87Rb, 93Nb, 95Mo, 103Rh, 143,145Na and 197Au and so called peele's permanent puzlle

  14. ASSESSMENT OF PRACTICE AT RETAIL PHARMACIES IN PAKISTAN: EXTENT OF COMPLIANCE WITH THE PREVAILING DRUG LAW OF PAKISTAN.

    Science.gov (United States)

    Ullah, Hanif; Zada, Wahid; Khan, Muhammad Sona; Iqbal, Muhammad; Chohan, Osaam; Raza, Naeem; Khawaja, Naeem Raza; Abid, Syed Mobasher Ali; Murtazai, Ghulam

    2016-01-01

    The main objective of this study was to assess the practice at retail pharmacies in Pakistan and to compare the same in rural and urban areas. The maintenance of pharmacy and drug inspectors' visit was also assessed. This cross sectional study was conducted in Abbottabad, Pakistan during October-November, 2012. A sample of 215 drug sellers or drug stores was selected by employing convenient sampling method. With a response rate of 91.6%, 197 drug sellers participated in this study. All the drug sellers were male. Overall, 35% (n = 197) of the drug sellers did not have any professional qualification. A majority of the drug sellers were involved in various malpractices like selling of medicines without prescription (80.7%), prescribing practice (60.9%), prescription intervention (62.4%) and selling of controlled substances (66%) without a license for selling it. These malpractices were significantly higher in rural area than that in urban area. PMID:27476300

  15. Systematics of pion emission in heavy ion collisions in the 1A GeV regime

    CERN Document Server

    Reisdorf, W; Barret, V; Basrak, Z; Bastid, N; Benabderrahmane, M L; Caplar, R; Crochet, P; Dupieux, P; Dzelalija, M; Fodor, Z; Grishkin, Y; Hartmann, O N; Herrmann, N; Hildenbrand, K D; Hong, B; Kang, T I; Kecskeméti, J; Kim, Y J; Kirejczyk, M; Kis, M; Koczón, P; Korolija, M; Kotte, R; Kress, T; Lebedev, A; Leifels, Y; López, X; Matulewicz, T; Merschmeyer, M; Neubert, W; Petrovici, M; Rami, F; Ryu, M S; Schüttauf, A; Seres, Z; Sikora, B; Sim, K S; Simion, V; Siwek-Wilczynska, K; Smolyankin, V; Stockmeier, M R; Stoicea, G; Tyminski, Z; Wisniewski, K; Wohlfarth, D; Xiao, Z G; Xu, H S; Yushmanov, I; Zhilin, A; al, et

    2006-01-01

    Using the large acceptance apparatus FOPI, we study pion emission in the reactions (energies in GeV/nucleon are given in parentheses): 40Ca+40Ca (0.4, 0.6, 0.8, 1.0, 1.5, 1.93), 96Ru+96Ru (0.4, 1.0, 1.5), 96Zr+96Zr (0.4, 1.0, 1.5), 197Au+197Au (0.4, 0.6, 0.8, 1.0, 1.2, 1.5). The observables include longitudinal and transverse rapidity distributions and stopping, polar anisotropies, pion multiplicities, transverse momentum spectra, ratios for positively and negatively charged pions of average transverse momenta and of yields, directed flow, elliptic flow. The data are compared to earlier data where possible and to transport model simulations.

  16. Systematics of central heavy ion collisions in the 1A GeV regime

    CERN Document Server

    Reisdorf, W; Averbeck, R; Benabderrahmane, M L; Hartmann, O N; Herrmann, N; Hildenbrand, K D; Kang, T I; Kim, Y J; Kis, M; Koczon, P; Kress, T; Leifels, Y; Merschmeyer, M; Piasecki, K; Schuettauf, A; Stockmeier, M; Barret, V; Basrak, Z; Bastid, N; Caplar, R; Crochet, P; Dupieux, P; Dzelalija, M; Fodor, Z; Gasik, P; Grishkin, Y; Hong, B; Kecskemeti, J; Kirejczyk, M; Korolija, M; Kotte, R; Lebedev, A; Lopez, X; Matulewicz, T; Neubert, W; Petrovici, M; Rami, F; Ryu, M S; Seres, Z; Sikora, B; Sim, K S; Simion, V; Siwek-Wilczynska, K; Smolyankin, V; Stoicea, G; Tyminski, Z; Wisniewski, K; Wohlfarth, D; Xiao, Z G; Xu, H S; Yushmanov, I; Zhilin, A

    2010-01-01

    Using the large acceptance apparatus FOPI, we study central collisions in the reactions (energies in A GeV are given in parentheses): 40Ca+40Ca (0.4, 0.6, 0.8, 1.0, 1.5, 1.93), 58Ni+58Ni (0.15, 0.25, 0.4), 96Ru+96Ru (0.4, 1.0, 1.5), 96Zr+96Zr (0.4, 1.0, 1.5), 129Xe+CsI (0.15, 0.25, 0.4), 197Au+197Au (0.09, 0.12, 0.15, 0.25, 0.4, 0.6, 0.8, 1.0, 1.2, 1.5). The observables include cluster multiplicities, longitudinal and transverse rapidity distributions and stopping, and radial flow. The data are compared to earlier data where possible and to transport model simulations.

  17. Study of the odd-${A}$, high-spin isomers in neutron-deficient trans-lead nuclei with ISOLTRAP

    CERN Multimedia

    Herfurth, F; Blaum, K; Beck, D; Kowalska, M; Schwarz, S; Stanja, J; Huyse, M L; Wienholtz, F

    We propose to measure the excitation energy of the $\\frac{13^{+}}{2}$ isomers in the neutron-deficient isotopes $^{193,195,197}$Po with the ISOLTRAP mass spectrometer. The assignment of the low- and high-spin isomers will be made by measuring the energy of the $\\alpha$- particles emitted in the decay of purified beams implanted in a windmill system. Using $\\alpha$-decay information, it is then also possible to determine the excitation energy of the similar isomers in the $\\alpha$-daughter nuclei $^{189,191,193}$Pb, $\\alpha$-parent nuclei $^{197,199,201}$Rn, and $\\alpha$-grand-parent nuclei $^{201,203,205}$Ra. The polonium beams are produced with a UC$_{\\textrm{x}}$ target and using the RILIS.

  18. Expression, crystallization and preliminary X-ray analysis of an anomeric inverting agarase from Pseudoalteromonas sp. CY24

    International Nuclear Information System (INIS)

    AgaB from Pseudoalterromonas sp. CY24 has been crystallized. The crystals of wild-type enzyme and the selenomethionine derivative diffracted to 1.97 and 2.64 Å, respectively. AgaB from Pseudoalteromonas sp. CY24 is a novel agarase that hydrolyzes agarose to generate products with inverted anomeric configuration and that has been proposed to have a larger catalytic cleft than other β-agarases. Here, the expression, purification, crystallization and data collection of AgaB in both wild-type and selenomethionine-substituted forms is described. The crystals of wild-type AgaB diffracted to 1.97 Å resolution and belonged to space group C2221. The selenomethionine derivative crystallized in space group I222. The phasing problem was solved by the multiwavelength anomalous dispersion (MAD) method. These results will facilitate detailed structural and enzymatic analysis of AgaB

  19. Experimental cross-sections for proton induced nuclear reactions on mercury up to 65 MeV

    Science.gov (United States)

    Hermanne, A.; Tárkányi, F.; Takács, S.; Ditrói, F.; Szücs, Z.; Brezovcsik, K.

    2016-07-01

    Cross-sections for formation of activation products induced by protons on natural mercury targets were measured. Results for 196m,196g,197g(cum), 198m,198g,199g(cum), 200g(cum), 201,202Tl, 194g(cum), 195g(cum), 196g(cum), 198m,199g(cum) Au and 195m,197m,203Hg are presented up to 65 MeV incident particle energy, many of these for the first time. The experimental data are compared with literature values and with the predictions of the TALYS 1.6 code (results taken from TENDL-2015 on-line library), thick target yields were derived and possible applications in biomedical sciences are discussed.

  20. Environmental radiation protection standards for Yucca Mountain

    International Nuclear Information System (INIS)

    The Environmental Protection Agency (EPA) has been given the responsibility of setting site-specific health and safety standards for the potential repository at Yucca Mountain, Nevada. The same legislation that gave the Agency that responsibility, mandated a study by the National Academy of Sciences (NAS) to provide input into the bases for the EPA standards. The NAS has completed and presented a report to the Agency; this paper summarizes the report's recommendations and conclusions. Following receipt of the report, the Agency opened a comment period and held public meetings to gather comments; the major issues from the comments are summarized. Based upon the report from NAS and the public comments, EPA has started formulating proposed standards which will be known as 40 CFR Part 197. It is planned for the proposal of 40 CFR Part 197 to occur in the summer of 1996