WorldWideScience

Sample records for astatine 195

  1. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  2. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  3. Adsorption interaction of astatine species with quartz and gold surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Serov, A. [Paul Scherrer Institute, Villigen (Switzerland). Lab. for Radiochemistry and Environmental Chemistry; Bern Univ. (Switzerland). Dept. for Chemistry and Biochemistry; Aksenov, N.; Bozhikov, G. [Joint Institute for Nuclear Research, Dubna (RU). Flerov Lab. of Nuclear Reactions] (and others)

    2011-07-01

    The adsorption interaction of various astatine species with quartz and gold surfaces was investigated by gas chromatography methods. Due to variations of the redox potential of the carrier gas elemental astatine, astatine oxide and hypo-astatic acid have been produced. The identification of the astatine compounds is based on the analogy assumption to the gas phase chemistry of the closest homologues in group 17 of the periodic table, iodine and bromine. The deposition temperatures as well as enthalpies of adsorption have been determined for the astatine species. The enhancement of the metallic character within group 17 towards higher Z is clearly confirmed. Macroscopic properties (sublimation enthalpy) of previously unstudied AtO{sub 2} and HAtO were estimated. The determined data for elemental astatine were compared to available literature data. Based on the obtained experimental results possible designs of experiments for studying of chemical properties of the recently discovered element 117 can be suggested. (orig.)

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. Discovery of the astatine, radon, francium, and radium isotopes

    CERN Document Server

    Fry, C

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  6. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  7. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  8. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  9. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  10. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  11. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom;

    2015-01-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...... and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting...... vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method...

  12. 49 CFR 195.114 - Used pipe.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Used pipe. 195.114 Section 195.114 Transportation... PIPELINE Design Requirements § 195.114 Used pipe. Any used pipe installed in a pipeline system must comply with § 195.112 (a) and (b) and the following: (a) The pipe must be of a known specification and...

  13. 32 CFR 195.5 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 195.5 Section 195.5 National... RIGHTS ACT OF 1964 § 195.5 Responsibilities. (a) The Assistant Secretary of Defense (Manpower) shall be...) to fulfill this responsibility in accordance with § 195.2(b). (c) The Assistant Secretary of...

  14. 49 CFR 195.54 - Accident reports.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Accident reports. 195.54 Section 195.54... PIPELINE Annual, Accident, and Safety-Related Condition Reporting § 195.54 Accident reports. (a) Each operator that experiences an accident that is required to be reported under § 195.50 shall as soon...

  15. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  16. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  17. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  18. 49 CFR 195.111 - Fracture propagation.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Fracture propagation. 195.111 Section 195.111... PIPELINE Design Requirements § 195.111 Fracture propagation. A carbon dioxide pipeline system must be designed to mitigate the effects of fracture propagation....

  19. 40 CFR 68.195 - Required corrections.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Required corrections. 68.195 Section 68.195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.195 Required corrections. The owner...

  20. 49 CFR 195.112 - New pipe.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false New pipe. 195.112 Section 195.112 Transportation... PIPELINE Design Requirements § 195.112 New pipe. Any new pipe installed in a pipeline system must comply with the following: (a) The pipe must be made of steel of the carbon, low alloy-high strength, or...

  1. 32 CFR 195.12 - Judicial review.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Judicial review. 195.12 Section 195.12 National... RIGHTS ACT OF 1964 § 195.12 Judicial review. Action taken pursuant to section 602 of the Act is subject to judicial review as provided in section 603 of the Act....

  2. 21 CFR 137.195 - Crushed wheat.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Crushed wheat. 137.195 Section 137.195 Food and... Related Products § 137.195 Crushed wheat. Crushed wheat, coarse ground wheat, is the food prepared by so crushing cleaned wheat other than durum wheat and red durum wheat that, when tested by the...

  3. 49 CFR 195.420 - Valve maintenance.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Valve maintenance. 195.420 Section 195.420 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Operation and Maintenance § 195.420 Valve maintenance. (a) Each operator shall maintain each...

  4. 49 CFR 195.260 - Valves: Location.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Valves: Location. 195.260 Section 195.260... PIPELINE Construction § 195.260 Valves: Location. A valve must be installed at each of the following... Administrator finds in a particular case that valves are not justified. (f) On each side of a reservoir...

  5. 49 CFR 195.116 - Valves.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Valves. 195.116 Section 195.116 Transportation... PIPELINE Design Requirements § 195.116 Valves. Each valve installed in a pipeline system must comply with the following: (a) The valve must be of a sound engineering design. (b) Materials subject to...

  6. 49 CFR 195.258 - Valves: General.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Valves: General. 195.258 Section 195.258... PIPELINE Construction § 195.258 Valves: General. (a) Each valve must be installed in a location that is accessible to authorized employees and that is protected from damage or tampering. (b) Each submerged...

  7. 49 CFR 195.224 - Welding: Weather.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions...

  8. 49 CFR 195.48 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.48 Section 195.48 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION... Annual, Accident, and Safety-Related Condition Reporting § 195.48 Scope. This subpart...

  9. 49 CFR 195.100 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.100 Section 195.100 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Design Requirements § 195.100 Scope. This subpart prescribes minimum design requirements for...

  10. 49 CFR 195.300 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.300 Section 195.300 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the...

  11. 49 CFR 195.200 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.200 Section 195.200 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.200 Scope. This subpart prescribes minimum requirements for constructing...

  12. 49 CFR 195.501 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.501 Section 195.501 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Qualification of Pipeline Personnel § 195.501 Scope. (a) This subpart prescribes the...

  13. 49 CFR 195.400 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.400 Section 195.400 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Operation and Maintenance § 195.400 Scope. This subpart prescribes minimum requirements...

  14. 49 CFR 195.0 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.0 Section 195.0 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION... General § 195.0 Scope. This part prescribes safety standards and reporting requirements for...

  15. 49 CFR 195.108 - External pressure.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false External pressure. 195.108 Section 195.108... PIPELINE Design Requirements § 195.108 External pressure. Any external pressure that will be exerted on the pipe must be provided for in designing a pipeline system....

  16. 49 CFR 195.262 - Pumping equipment.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Pumping equipment. 195.262 Section 195.262... PIPELINE Construction § 195.262 Pumping equipment. (a) Adequate ventilation must be provided in pump... warn of the presence of hazardous vapors in the pumping station building. (b) The following must...

  17. 49 CFR 195.408 - Communications.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Communications. 195.408 Section 195.408... PIPELINE Operation and Maintenance § 195.408 Communications. (a) Each operator must have a communication... system. (b) The communication system required by paragraph (a) of this section must, as a...

  18. 49 CFR 195.102 - Design temperature.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Design temperature. 195.102 Section 195.102... PIPELINE Design Requirements § 195.102 Design temperature. (a) Material for components of the system must be chosen for the temperature environment in which the components will be used so that the...

  19. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  20. 49 CFR 195.422 - Pipeline repairs.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Pipeline repairs. 195.422 Section 195.422 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS...

  1. 43 CFR 19.5 - Hearing procedures.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Hearing procedures. 19.5 Section 19.5 Public Lands: Interior Office of the Secretary of the Interior WILDERNESS PRESERVATION National... concerning the suitability or nonsuitability of any roadless area or island for preservation as wilderness...

  2. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  3. 32 CFR 195.7 - Compliance information.

    Science.gov (United States)

    2010-07-01

    ... TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 § 195.7 Compliance information. (a) Cooperation and assistance... data showing the extent to which members of minority groups are beneficiaries of federally...

  4. 49 CFR 195.214 - Welding procedures.

    Science.gov (United States)

    2010-10-01

    ... accordance with welding procedures qualified under Section 5 of API 1104 or Section IX of the ASME Boiler and Pressure Vessel Code (incorporated by reference, see § 195.3) . The quality of the test welds used...

  5. Reexamining the half-lives of 195Os and 195Ir

    CERN Document Server

    Birch, M; Schaedig, Z; Singh, B; Thoennessen, M

    2013-01-01

    Currently the half-life of 195Os is listed as unknown in most databases because the value of the only available measurement had been reassigned. We argue that the original assignment is correct and re-evaluate the half-life of 195Os to be 6.5(11)min, consistent with the original measurement. We also suggest to reassign the half-life of 195Ir to 2.29(17)h.

  6. Dicty_cDB: SLB195 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLB195 (Link to dictyBase) - - - Contig-U16455-1 SLB195Z (Link... to Original site) - - SLB195Z 709 - - - - Show SLB195 Library SL (Link to library) Clone ID SLB195 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLB1-D/SLB195Q.Seq.d/ Representative seq. ID SLB19...5Z (Link to Original site) Representative DNA sequence >SLB195 (SLB195Q) /CSM/SL/SLB1-D/SLB195Q.Seq.d/ XXXXX... ) Dictyostelium discoideum slug cDNA, clone SLE193. 1298 0.0 1 ( AU034146 ) Dictyostelium discoideum slug cDNA, clone SLB

  7. 49 CFR 195.440 - Public awareness.

    Science.gov (United States)

    2010-10-01

    ... significant number and concentration of the non-English speaking population in the operator's area. (h... Petroleum Institute's (API) Recommended Practice (RP) 1162 (incorporated by reference, see § 195.3). (b) The... or certain provisions of the recommended practice is not practicable and not necessary for safety....

  8. Dicty_cDB: CHS195 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHS195 (Link to dictyBase) - - - Contig-U16423-1 - (Link to Original site) - - CHS19...5Z 671 - - - - Show CHS195 Library CH (Link to library) Clone ID CHS195 (Link to dicty...iol.tsukuba.ac.jp/CSM/CH/CHS1-D/CHS195Q.Seq.d/ Representative seq. ID - (Link to ...Original site) Representative DNA sequence >CHS195 (CHS195Q) /CSM/CH/CHS1-D/CHS195Q.Seq.d/ XXXXXXXXXXTTGAAAC....00 44.0 %: nuclear 28.0 %: cytoplasmic 20.0 %: cytoskeletal 4.0 %: mitochondrial 4.0 %: peroxisomal >> prediction for CHS19

  9. Lifetime measurement in {sup 195}Po

    Energy Technology Data Exchange (ETDEWEB)

    Grahn, T.; Page, R.D. [University of Liverpool, Department of Physics, Oliver Lodge Laboratory, Liverpool (United Kingdom); Dewald, A.; Jolie, J.; Melon, B.; Pissulla, T. [Universitaet zu Koeln, Institut fuer Kernphysik, Koeln (Germany); Greenlees, P.T.; Jakobsson, U.; Jones, P.; Julin, R.; Juutinen, S.; Ketelhut, S.; Leino, M.; Nyman, M.; Peura, P.; Rahkila, P.; Saren, J.; Scholey, C.; Sorri, J.; Uusitalo, J. [University of Jyvaeskylae, Department of Physics, P.O. Box 35, Jyvaeskylae (Finland); Kroell, T.; Kruecken, R.; Maierbeck, P. [TU Muenchen, Physik-Department E12, Garching (Germany)

    2009-03-15

    The lifetime of the 17/2{sup +} yrast state in {sup 195}Po has been measured using the recoil distance Doppler-shift technique to be {tau}=43(11) ps. The lifetime was extracted from the singles {gamma}-ray spectra obtained by using the recoil-decay tagging method. The present work provides more information of the coupling schemes, shapes and configuration mixing in neutron-deficient odd-mass Po nuclei. (orig.)

  10. 49 CFR 195.212 - Bending of pipe.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Bending of pipe. 195.212 Section 195.212... PIPELINE Construction § 195.212 Bending of pipe. (a) Pipe must not have a wrinkle bend. (b) Each field bend must comply with the following: (1) A bend must not impair the serviceability of the pipe. (2)...

  11. 49 CFR 195.207 - Transportation of pipe.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Transportation of pipe. 195.207 Section 195.207... PIPELINE Construction § 195.207 Transportation of pipe. (a) Railroad. In a pipeline operated at a hoop stress of 20 percent or more of SMYS, an operator may not use pipe having an outer diameter to...

  12. 49 CFR 195.438 - Smoking or open flames.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Smoking or open flames. 195.438 Section 195.438 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Operation and Maintenance § 195.438 Smoking or open flames. Each operator shall prohibit...

  13. 49 CFR 195.404 - Maps and records.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Maps and records. 195.404 Section 195.404... PIPELINE Operation and Maintenance § 195.404 Maps and records. (a) Each operator shall maintain current maps and records of its pipeline systems that include at least the following information: (1)...

  14. 49 CFR 195.406 - Maximum operating pressure.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Maximum operating pressure. 195.406 Section 195.406 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Operation and Maintenance § 195.406 Maximum operating pressure. (a) Except...

  15. 37 CFR 1.95 - Copies of exhibits.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Copies of exhibits. 1.95 Section 1.95 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF..., Specimens § 1.95 Copies of exhibits. Copies of models or other physical exhibits will not ordinarily...

  16. 49 CFR 195.208 - Welding of supports and braces.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding of supports and braces. 195.208 Section 195.208 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS... HAZARDOUS LIQUIDS BY PIPELINE Construction § 195.208 Welding of supports and braces. Supports or braces...

  17. 49 CFR 195.226 - Welding: Arc burns.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding: Arc burns. 195.226 Section 195.226 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.226 Welding: Arc burns. (a) Each arc burn must be repaired. (b) An arc burn...

  18. 49 CFR 195.442 - Damage prevention program.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Damage prevention program. 195.442 Section 195.442... PIPELINE Operation and Maintenance § 195.442 Damage prevention program. (a) Except as provided in paragraph... section. (1) The state has adopted a one-call damage prevention program under § 198.37 of this chapter;...

  19. 49 CFR 195.446 - Control room management.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Control room management. 195.446 Section 195.446... PIPELINE Operation and Maintenance § 195.446 Control room management. (a) General. This section applies to... written control room management procedures that implement the requirements of this section. The...

  20. 49 CFR 195.308 - Testing of tie-ins.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Testing of tie-ins. 195.308 Section 195.308 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be...

  1. 46 CFR 195.11-30 - Portable tanks.

    Science.gov (United States)

    2010-10-01

    ... containing other hazardous materials shall be in accordance with the requirements of 49 CFR parts 171-179. ... 46 Shipping 7 2010-10-01 2010-10-01 false Portable tanks. 195.11-30 Section 195.11-30 Shipping... AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-30 Portable tanks. (a)...

  2. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  3. Dicty_cDB: CHP195 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHP195 (Link to dictyBase) - - - Contig-U11819-1 - (Link to Or...iginal site) CHP195F 138 - - - - - - Show CHP195 Library CH (Link to library) Clone ID CHP195 (Link to dicty...Base) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U11819-1 Original site URL http://dictycdb.b...qilkvstnk**IKNYYVNRVYEIIIIINICTYKKK--- Translated Amino Acid sequence (All Frames) Frame A: tvgllvfsnt*gink*...iin*kllck*sl*nnnynkymyi*kk--- Frame B: llaywffqilkvstnk**IKNYYVNRVYEIIIIINICTYKKK--- Frame C: cwptgffkylryqq

  4. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  5. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  6. 40 CFR 160.195 - Retention of records.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Retention of records. 160.195 Section 160.195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS GOOD... used to support an application for a research or marketing permit approved by EPA, the period...

  7. 19 CFR 10.195 - Country of origin criteria.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Country of origin criteria. 10.195 Section 10.195... Country of origin criteria. (a) Articles produced in a beneficiary country—(1) General. Except as provided... the country of origin of the article or material. (b) Commonwealth of Puerto Rico and U.S....

  8. 49 CFR 195.248 - Cover over buried pipeline.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Cover over buried pipeline. 195.248 Section 195.248 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION...

  9. 46 CFR 174.195 - Bulkheads in machinery spaces.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Bulkheads in machinery spaces. 174.195 Section 174.195... in machinery spaces. (a) The bulkhead in each machinery space of each OSV must be watertight to the bulkhead deck. (b) Each penetration of, and each opening in, a bulkhead in a machinery space must— (1)...

  10. The progress of researchon microRNA-195%microRNA-195的研究进展

    Institute of Scientific and Technical Information of China (English)

    褚阳; 张玉瑶; 王旭; 刘成娣; 陈罄馨; 班涛

    2015-01-01

    microRNA-195(miR-195)是miR-15家族的成员之一,因其在多种疾病中高度异常表达,近年来受到广泛关注.它具有高度保守性,通过与靶基因的3'-UTR区的相应靶位点相结合,调控了细胞的增殖、分化、转移、凋亡等多种过程,进而参与了肿瘤、心血管、神经中枢等疾病的发生发展过程.同时,miR-195的表达还受上游转录因子及表观遗传修饰等调节.本文就miR-195的重要功能,上游调控因子与疾病的关系以及在疾病进程中的调控机制作一综述.%MiR-195,one member of the miR-15 family,has been paid great attention so far,because it shows highly abnormal expression in various diseases.MiR-195 is highly conserved,and can regulate cell cycle,cell differentiation,metastasis,apoptosis and other important cellular functions by regulating the 3 '-UTR of target genes.MiR-195 is involved in cancer,cardiovascular diseases,neurodegenerative diseases,etc.The expression of miR-195 is also regulated by transcription factors,epigenetic modifications,and so on.In the present paper,we review the important functions,upstream regulating factors,the relationship with diseases and mechanisms regulating the progress of miR-195-associated diseases.

  11. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  12. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  13. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  14. 42 CFR 413.195 - Limitation on Review.

    Science.gov (United States)

    2010-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE... Disease (ESRD) Services and Organ Procurement Costs § 413.195 Limitation on Review. Administrative or... establishment of the market basket percentage increase factors under section 1881(b)(14)(F) of the...

  15. A new high-spin isomer in {sup 195}Bi

    Energy Technology Data Exchange (ETDEWEB)

    Roy, T.; Mukherjee, G.; Rana, T.K.; Bhattacharya, Soumik; Asgar, Md.A.; Bhattacharya, C.; Bhattacharya, S.; Bhattacharyya, S.; Pai, H. [Variable Energy Cyclotron Centre, Kolkata (India); Madhavan, N.; Bala, I.; Gehlot, J.; Gurjar, R.K.; Jhingan, A.; Kumar, R.; Muralithar, S.; Nath, S.; Singh, R.P.; Varughese, T. [Inter University Acclerator Centre, New Delhi (India); Basu, K.; Bhattacharjee, S.S.; Ghugre, S.S.; Raut, R.; Sinha, A.K. [UGC-DAE-CSR Kolkata Centre, Kolkata (India); Palit, R. [Tata Institute of Fundamental Research, Department of Nuclear and Atomic Physics, Mumbai (India)

    2015-11-15

    A new high-spin isomer has been identified in {sup 195}Bi at the focal plane of the HYbrid Recoil mass Analyser (HYRA) used in the gas-filled mode. The fusion evaporation reactions {sup 169}Tm ({sup 30}Si, x n) {sup 193,} {sup 195}Bi were used with the beam energies on targets of 168 and 146MeV for 6n and 4n channels, respectively. The evaporation residues, separated from the fission fragments, and their decays were detected at the focal plane of HYRA using MWPC, Si-Pad and clover HPGe detectors. The half-life of the new isomer in {sup 195}Bi has been measured to be 1.6(1) μs. The configuration of the new isomer has been proposed and compared with the other isomers in this region. The Total Routhian Surface (TRS) calculations for the three-quasiparticle configurations corresponding to the new isomer suggest an oblate deformation for this isomeric state. The same calculations for different configurations in {sup 195}Bi and for the even-even {sup 194}Pb core indicate that the proton i{sub 13/2} orbital has a large shape driving effect towards oblate shape in these nuclei. (orig.)

  16. 46 CFR 154.195 - Aluminum cargo tank: Steel enclosure.

    Science.gov (United States)

    2010-10-01

    ... published in “Rules for Building and Classing Steel Vessels”, 1981. (c) The steel cover for the aluminum... 46 Shipping 5 2010-10-01 2010-10-01 false Aluminum cargo tank: Steel enclosure. 154.195 Section... CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design, Construction...

  17. 26 CFR 1.195-1 - Election to amortize start-up expenditures.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Election to amortize start-up expenditures. 1.195-1 Section 1.195-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Itemized Deductions for Individuals and Corporations (continued) § 1.195-1 Election to amortize...

  18. 26 CFR 1.195-1T - Election to amortize start-up expenditures (temporary).

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Election to amortize start-up expenditures (temporary). 1.195-1T Section 1.195-1T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Itemized Deductions for Individuals and Corporations (continued) § 1.195-1T Election to...

  19. 28 CFR 19.5 - Report to the Office of Juvenile Justice and Delinquency Prevention.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Report to the Office of Juvenile Justice and Delinquency Prevention. 19.5 Section 19.5 Judicial Administration DEPARTMENT OF JUSTICE USE OF PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 19.5 Report to the Office of Juvenile Justice and Delinquency Prevention. DOJ...

  20. 49 CFR 195.587 - What methods are available to determine the strength of corroded pipe?

    Science.gov (United States)

    2010-10-01

    ... strength of corroded pipe? 195.587 Section 195.587 Transportation Other Regulations Relating to... methods are available to determine the strength of corroded pipe? Under § 195.585, you may use the... Pipe (with RSTRENG disk),” to determine the strength of corroded pipe based on actual remaining...

  1. 40 CFR 1065.195 - PM-stabilization environment for in-situ analyzers.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false PM-stabilization environment for in-situ analyzers. 1065.195 Section 1065.195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.195...

  2. 49 CFR 195.561 - When must I inspect pipe coating used for external corrosion control?

    Science.gov (United States)

    2010-10-01

    ... corrosion control? 195.561 Section 195.561 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.561 When must I inspect pipe coating used for external corrosion control? (a) You must inspect all external pipe...

  3. 49 CFR 195.559 - What coating material may I use for external corrosion control?

    Science.gov (United States)

    2010-10-01

    ... corrosion control? 195.559 Section 195.559 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.559 What coating material may I use for external corrosion control? Coating material for external corrosion control...

  4. 49 CFR 195.557 - Which pipelines must have coating for external corrosion control?

    Science.gov (United States)

    2010-10-01

    ... corrosion control? 195.557 Section 195.557 Transportation Other Regulations Relating to Transportation...) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.557 Which pipelines must have coating for external corrosion control? Except bottoms of aboveground breakout tanks,...

  5. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  6. Studies of {sup 194,195,197}Po

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, M.P.; Ahmad, I.; Crowell, B. [and others

    1995-08-01

    The energy systematics of low-lying polonium states show sudden changes near N = 114. The observed drops in the low-lying levels of {sup 196,198}Po relative to the heavier isotopes indicate significant changes in the underlying structure of these nuclei. It is thought that this change is due to the onset of vibrational collectivity brought about by the quadrupole interaction between neutron and proton-pairs. In order to extend the Po systematics even further, we measured, for the first time, states in {sup 194,195,197}Po using the {sup 28}Si + {sup 170}Yb reaction at a beam energy of 142 MeV. The beam was supplied by ATLAS, and the data were taken with 10 Compton-suppressed Ge detectors placed at the target position of the Fragment Mass Analyzer. Preliminary level schemes were constructed for {sup 194,195,197}Po based on {gamma}-{gamma} and {gamma}-FMA coincidences. The results for {sup 194}Po show that the 2{sup +} - 0{sup +} transition energy decreased in energy by 140 keV relative to {sup 196}Po suggesting that this nucleus moved beyond the vibrational limit to more collective motion. An extrapolation of the systematics predicts that the 2{sup +} energy could drop another 140 keV between {sup 194}Po and {sup 192}Po which would indicate the onset of rotational motion. Currently, we have an approved experiment to investigate the decay of yrast isomers in {sup 194}Po which will allow us to (1) confirm our earlier level scheme of {sup 194}Po, and (2) assess the experimental conditions needed for a future study of {sup 192}Po.

  7. A 1.95 GHz Doherty Power Amplifier%1.95GHz Doherty功率放大器设计

    Institute of Scientific and Technical Information of China (English)

    徐长久; 孙玲玲; 文进才; 余志平

    2011-01-01

    基于SMIC 0.18 μm RF CMOS工艺,设计了一款1.95 GHz的Doherty功率放大器.为了保持两路功放相位最大一致性,主功放(PA1)和辅功放(PA2)采用了同一种CMOS功率放大器,仅改变其偏压使其工作在不同模式.CMOS功率放大器为工作于AB类的两级放大电路,集成了输入和级间匹配网络;功分器以及λ/4调制网络在PCB板上实现.在3 V供电,工作频率为1.95 GHz时,CMOS功率放大器输出功率为23 dBm,增益为16dB,功率附加效率(PAE)为30%;Doherty功率放大器输出功率为25 dBm,功率附加效率为15%.%In this work, a 1.95 GHz Doherty power amplifier is presented by using SMIC 0. 18 μm RF-CMOS technology. In order to keep identical in phase of two power amplifiers, the main power amplifier and the auxiliary power amplifier have same schematic and layout, only change the bias and work in different modes. The CMOS power amplifiers have two stages and work in class AB mode. The power divider and λ/4 transformer are printed on the PCB board. At a 3 V voltage supply,the CMOS power amplifier provides a maximum output power of 23 dBm,and a PAE up to 30%. The Doherty power amplifier has a output power of 25 dBm,and a PAE up to 15%.

  8. 32 CFR Appendix A to Part 195 - Programs to Which This Part Applies

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Programs to Which This Part Applies A Appendix A...-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 Pt. 195, App. A Appendix A to Part 195—Programs to... consideration, or at a nominal or reduced consideration, on lands under the control of the Department of...

  9. 49 CFR 195.579 - What must I do to mitigate internal corrosion?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false What must I do to mitigate internal corrosion? 195... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.579 What must I do to mitigate internal corrosion? (a) General. If you transport any hazardous liquid or carbon dioxide...

  10. 49 CFR 195.4 - Compatibility necessary for transportation of hazardous liquids or carbon dioxide.

    Science.gov (United States)

    2010-10-01

    ... hazardous liquids or carbon dioxide. 195.4 Section 195.4 Transportation Other Regulations Relating to... necessary for transportation of hazardous liquids or carbon dioxide. No person may transport any hazardous liquid or carbon dioxide unless the hazardous liquid or carbon dioxide is chemically compatible with...

  11. 46 CFR 195.07-10 - Lakes, bays, and sounds, or river service.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Lakes, bays, and sounds, or river service. 195.07-10 Section 195.07-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Lakes, bays, and sounds, or river service. (a) Vessels in lakes, bays, and sounds, or river...

  12. 46 CFR 195.07-5 - Ocean, coastwise, or Great Lakes service.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Ocean, coastwise, or Great Lakes service. 195.07-5 Section 195.07-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Ocean, coastwise, or Great Lakes service. (a) Vessels in ocean, coastwise, or Great Lakes service...

  13. 24 CFR 200.195 - Removal of nonprofit organization from Nonprofit Organization Roster.

    Science.gov (United States)

    2010-04-01

    ... prohibits HUD from taking such other action against a nonprofit organization, as provided in 2 CFR part 2424... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Removal of nonprofit organization from Nonprofit Organization Roster. 200.195 Section 200.195 Housing and Urban Development...

  14. 14 CFR 121.195 - Airplanes: Turbine engine powered: Landing limitations: Destination airports.

    Science.gov (United States)

    2010-01-01

    ... limitations: Destination airports. 121.195 Section 121.195 Aeronautics and Space FEDERAL AVIATION...: Destination airports. (a) No person operating a turbine engine powered airplane may take off that airplane at... alternate airport) the weight of the airplane on arrival would exceed the landing weight set forth in...

  15. Role of microRNA-195 in cardiomyocyte apoptosis induced by myocardial ischaemia–reperfusion injury

    Indian Academy of Sciences (India)

    Chang-Kui Gao; Hui Liu; Cheng-Ji Cui; Zhao-Guang Liang; Hong Yao; Ye Tian

    2016-03-01

    This study aims to investigate microRNA-195 (miR-195) expression in myocardial ischaemia–reperfusion (I/R) injury and the roles of miR-195 in cardiomyocyte apoptosis though targeting Bcl-2. A mouse model of I/R injury was established. MiR-195 expression levels were detected by real-time quantitative PCR (qPCR), and the cardiomyocyte apoptosis was detected by TUNEL assay. After cardiomyocytes isolated from neonatal rats and transfected with miR-195 mimic or inhibitor, the hypoxia/reoxygenation (H/R) injury model was established. Cardiomyocyte apoptosis and mitochondrial membrane potential were evaluated using flow cytometry. Bcl-2 and Bax mRNA expressions were detected by RT-PCR. Bcl-2, Bax and cytochrome c (Cyt-c) protein levels were determined by Western blot. Caspase-3 and caspase-9 activities were assessed by luciferase assay. Compared with the sham group, miR-195 expression levels and rate of cardiomyocyte apoptosis increased significantly in I/R group (both < 0.05). Compared to H/R + negative control (NC) group, rate of cardiomyocyte apoptosis increased in H/R + miR-195 mimic group while decreased in H/R + miR-195 inhibitor group (both < 0.05). MiR-195 knockdown alleviated the loss of mitochondrial membrane potential ( < 0.05). MiR-195 overexpression decreased Bcl-2 mRNA and protein expression, increased BaxmRNA and protein expression, Cyt-c protein expression and caspase-3 and caspase-9 activities (all < 0.05). While, downregulated MiR-195 increased Bcl-2 mRNA and protein expression, decreased Bax mRNA and protein expression, Cyt-c protein expression and caspase-3 and caspase-9 activities (all < 0.05). Our study identified that miR-195 expression was upregulated in myocardial I/R injury, and miR-195 overexpression may promote cardiomyocyte apoptosis by targeting Bcl-2 and inducing mitochondrial apoptotic pathway.

  16. 49 CFR 195.581 - Which pipelines must I protect against atmospheric corrosion and what coating material may I use?

    Science.gov (United States)

    2010-10-01

    ... corrosion and what coating material may I use? 195.581 Section 195.581 Transportation Other Regulations... Corrosion Control § 195.581 Which pipelines must I protect against atmospheric corrosion and what coating... atmosphere, except pipelines under paragraph (c) of this section. (b) Coating material must be suitable...

  17. 49 CFR 195.413 - Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets.

    Science.gov (United States)

    2010-10-01

    ... the Gulf of Mexico and its inlets. 195.413 Section 195.413 Transportation Other Regulations Relating... Maintenance § 195.413 Underwater inspection and reburial of pipelines in the Gulf of Mexico and its inlets. (a... shall prepare and follow a procedure to identify its pipelines in the Gulf of Mexico and its inlets...

  18. 49 CFR 195.12 - What requirements apply to low-stress pipelines in rural areas?

    Science.gov (United States)

    2010-10-01

    ... § 195.452(a) in lieu of the half mile buffer. (iii) Complete the baseline assessment of all segments in... for the estimate); the estimated amount of production from affected wells per year, whether wells...

  19. Comparative genomics of "Dehalococcoides ethenogenes" 195 and an enrichment culture containing unsequenced "Dehalococcoides" strains.

    Science.gov (United States)

    West, Kimberlee A; Johnson, David R; Hu, Ping; DeSantis, Todd Z; Brodie, Eoin L; Lee, Patrick K H; Feil, Helene; Andersen, Gary L; Zinder, Stephen H; Alvarez-Cohen, Lisa

    2008-06-01

    Tetrachloroethene (PCE) and trichloroethene (TCE) are prevalent groundwater contaminants that can be completely reductively dehalogenated by some "Dehalococcoides" organisms. A Dehalococcoides-organism-containing microbial consortium (referred to as ANAS) with the ability to degrade TCE to ethene, an innocuous end product, was previously enriched from contaminated soil. A whole-genome photolithographic microarray was developed based on the genome of "Dehalococcoides ethenogenes" 195. This microarray contains probes designed to hybridize to >99% of the predicted protein-coding sequences in the strain 195 genome. DNA from ANAS was hybridized to the microarray to characterize the genomic content of the ANAS enrichment. The microarray results revealed that the genes associated with central metabolism, including an apparently incomplete carbon fixation pathway, cobalamin-salvaging system, nitrogen fixation pathway, and five hydrogenase complexes, are present in both strain 195 and ANAS. Although the gene encoding the TCE reductase, tceA, was detected, 13 of the 19 reductive dehalogenase genes present in strain 195 were not detected in ANAS. Additionally, 88% of the genes in predicted integrated genetic elements in strain 195 were not detected in ANAS, consistent with these elements being genetically mobile. Sections of the tryptophan operon and an operon encoding an ABC transporter in strain 195 were also not detected in ANAS. These insights into the diversity of Dehalococcoides genomes will improve our understanding of the physiology and evolution of these bacteria, which is essential in developing effective strategies for the bioremediation of PCE and TCE in the environment. PMID:18359838

  20. Investigating the relationship between MicroRNA-195 and Smad7%MicroRNA-195与Smad7靶向关系的研究

    Institute of Scientific and Technical Information of China (English)

    孔彪; 沈冬丽; 芮涛; 张国辉

    2015-01-01

    目的:构建含有Smad7基因3′-UTR区的荧光素酶报告基因载体,利用双荧光素酶报告基因验证MicroR-NA195与其潜在靶基因Smad7的靶向关系。方法:PCR扩增出Smad7基因3′-UTR区片段,以此构建含3′-UTR的荧光素酶报告基因载体(wild type,WT);将miRNA-195与荧光素酶报告重组子共转染至293T细胞中,双荧光素酶报告基因系统检测荧光素酶活性;构建含Smad7基因3′-UTR突变体(mutant,Mut)的荧光素酶报告基因质粒,检测荧光素酶活性变化。结果:测序结果表明,含有Smad7基因3′-UTR区的荧光素酶报告基因载体构建正确;荧光素酶活性实验表明,与对照组相比,miRNA-195可使含Smad7基因3′-UTR区的荧光素酶报告重组子的荧光素酶活性降低40%左右;而定点突变Smad7基因3′-UTR的荧光素酶报告重组子荧光活性未有明显变化。结论:成功构建了Smad7基因3′-UTR区的荧光素酶报告基因载体,而miRNA-195可以直接作用于Smad7基因3′-UTR区,抑制其荧光素酶活性。%Objective:The luciferase reporter vector containing 3′-UTR of Smad7 was constructed.Dual luciferase reporter gene system was applied to determine the association between miRNA-195 and its target gene Smad7 .Methods:The 3′-UTR of Smad7 fragment amplified by PCR was cloned into luciferase vec-tor.MiRNA-195 and the luciferase reporters containing 3′-UTR(Smad7-3′UTR-WT)or mutant 3′-UTR (Smad7-3′UTR-Mut)of Smad7 were co-transfected into HEK293T cells and dual luciferase reporter gene system was applied to test luciferase activity.Results:DNA sequencing showed that the sequences of the cloned regions were correct.The luciferase activity of Smad7-3′UTR-WT plasmid treated with miRNA-195 was decreased to about 40%compared with control.The mutant 3′-UTR were no longer repressed by miR-NA-195.Conclusion:The Smad7 3′-UTR luciferase reporter vector has been constructed successfully

  1. Knockdown of microRNA-195 contributes to protein phosphatase-2A inactivation in rats with chronic brain hypoperfusion.

    Science.gov (United States)

    Liu, Cheng-Di; Wang, Qin; Zong, De-Kang; Pei, Shuang-Chao; Yan, Yan; Yan, Mei-Ling; Sun, Lin-Lin; Hao, Yang-Yang; Mao, Meng; Xing, Wen-Jing; Ren, Huan; Ai, Jing

    2016-09-01

    Reduction of protein phosphatase-2A (PP2A) activity is a common clinical feature of Alzheimer's disease and vascular dementia. In this study, we observed that chronic brain hypoperfusion induced by bilateral common carotid artery occlusion of rats led to PP2A inactivation based on the increase in tyrosine-307 phosphorylation and leucine-309 demethylation of PP2AC and the depression in PP2ABα. Knockdown of miR-195 using overexpression of its antisense molecule oligonucleotide (pre-AMO-miR-195) delivered by a lentivirus (lenti-pre-AMO-miR-195) increased tyrosine-307 phosphorylation and decreased both PP2ABα expression and leucine-309 methylation; these effects were prevented by the overexpression of miR-195 using lenti-pre-miR-195 and controlled by an increase in methylesterase (PME-1) and a decrease in leucine carboxyl methyltransferase-1. In vitro studies demonstrated that miR-195 regulated PME-1 expression by binding to the Ppme1 gene 3'-untranslated region (3'UTR) domain. Masking the miR-195 binding sites in the amyloid precursor protein (APP) and β-site APP cleaving enzyme 1 genes prevented miR-195-induced leucine carboxyl methyltransferase-1 elevation. We concluded that the miR-195 downregulation in chronic brain hypoperfusion involved PP2A inactivity, which was mediated by the post-transcriptional regulation PME-1, APP, and β-site APP cleaving enzyme 1 expression. PMID:27459928

  2. Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase.

    Science.gov (United States)

    Okada, Motoi; Kim, Ha Won; Matsu-ura, Kaoru; Wang, Yi-Gang; Xu, Meifeng; Ashraf, Muhammad

    2016-01-01

    Previously, we reported that a novel subpopulation of young mesenchymal stem cells (YMSCs) existed in old bone marrow, which possessed high antiaging properties as well as excellent efficacy for cardiac repair. MicroRNAs (miRNAs) have emerged as key regulators in post-transcriptional gene expression programs, and however, it is unknown whether miRNAs directly control stem cell senescence. Here we present the first evidence that miR-195 overexpressed in old MSCs (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR-195 can reverse stem cell aging. MiRNAs profiling analysis in YMSCs and OMSCs by microarray showed that miR-140, miR-146a/b, and miR-195 were significantly upregulated in OMSCs, which led us to hypothesize that these are age-induced miRNAs involved in stem cell senescence. Of these miRNAs, we found miR-195 directly targeted 3'-untranslated region of Tert gene by computational target prediction analysis and luciferase assay, and knockdown of miR-195 significantly increased Tert expression in OMSCs. Strikingly, miR-195 inhibition significantly induced telomere relengthening in OMSCs along with reduced expression of senescence-associated β-galactosidase. Moreover, silencing miR-195 in OMSCs by transfection of miR-195 inhibitor significantly restored antiaging factors expression including Tert and Sirt1 as well as phosphorylation of Akt and FOXO1. Notably, abrogation of miR-195 markedly restored proliferative abilities in OMSCs. Transplantation of OMSCs with knocked out miR-195 reduced infarction size and improved LV function. In conclusion, rejuvenation of aged stem cells by miR-195 inhibition would be a promising autologous therapeutic strategy for cardiac repair in the elderly patients. PMID:26390028

  3. Unusual foreign body in the vesico-urethral; 195 cm liquid pipe

    OpenAIRE

    Sökmen, Doğukan; Törer, Buğra Doğukan; Kargı, Taner; Yavuzsan, Abdullah Hızır; Şahin, Selçuk; Tuğcu, Volkan

    2014-01-01

    Insertion of foreign bodies into the genitourinary system is a pathological action believed to increase sexual gratification usually for psychiatric patients and mentally retarded cases especially during masturbation. In this report, we represented a male case who is inserted a 195 cm cannula by himself into the bladder through the urethra because of his psychiatric disorder.

  4. Unusual foreign body in the vesico-urethral; 195 cm liquid pipe.

    Science.gov (United States)

    Sökmen, Doğukan; Törer, Buğra Doğukan; Kargı, Taner; Yavuzsan, Abdullah Hızır; Şahin, Selçuk; Tuğcu, Volkan

    2014-12-01

    Insertion of foreign bodies into the genitourinary system is a pathological action believed to increase sexual gratification usually for psychiatric patients and mentally retarded cases especially during masturbation. In this report, we represented a male case who is inserted a 195 cm cannula by himself into the bladder through the urethra because of his psychiatric disorder. PMID:26328187

  5. 49 CFR 195.585 - What must I do to correct corroded pipe?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false What must I do to correct corroded pipe? 195.585... pipe? (a) General corrosion. If you find pipe so generally corroded that the remaining wall thickness... pipe. However, you need not replace the pipe if you— (1) Reduce the maximum operating...

  6. 49 CFR 195.101 - Qualifying metallic components other than pipe.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Qualifying metallic components other than pipe... components other than pipe. Notwithstanding any requirement of the subpart which incorporates by reference an edition of a document listed in § 195.3, a metallic component other than pipe manufactured in...

  7. Murine Extracellular Superoxide Dismutase Is Converted into the Inactive Fold by the Ser195Cys Mutation

    DEFF Research Database (Denmark)

    Scavenius, Carsten; Petersen, Jane Savskov; Thomsen, Line Rold;

    2013-01-01

    of the murine EC-SOD was significantly reduced by the mutation. Collectively, these data suggest that Cys195 actuates the formation of iEC-SOD, independent of the expression system or host. In addition, the dual-folding pathway most likely requires biosynthesis factors that are common to both humans and rodents....

  8. 49 CFR 195.452 - Pipeline integrity management in high consequence areas.

    Science.gov (United States)

    2010-10-01

    ...; (viii) Exposure of the pipeline to operating pressure exceeding established maximum operating pressure... 49 Transportation 3 2010-10-01 2010-10-01 false Pipeline integrity management in high consequence... Management § 195.452 Pipeline integrity management in high consequence areas. (a) Which pipelines are...

  9. 33 CFR 110.195 - Mississippi River below Baton Rouge, LA, including South and Southwest Passes.

    Science.gov (United States)

    2010-07-01

    ... cargos of particular hazard as defined in 33 CFR 126.10 or cargos of petroleum products in bulk may not... citations affecting § 110.195, see the List of CFR Sections Affected, which appears in the Finding Aids...) Belle Chasse Anchorage. An area 2.1 miles in length along the right descending bank of the...

  10. Classifications,symptoms and imaging findings of 195 cases confirmed by biopsy or postoperative pathology

    Institute of Scientific and Technical Information of China (English)

    董秦雯

    2014-01-01

    Objective To summarize and analyze the classifications,symptoms,imaging findings of the cerebral space occupying lesions which confirmed by biopsy or postoperative pathology.Methods The classifications,symptoms,imaging findings of 195 cases who visited the Neurology Department of Naval General Hospital were analyzed by retrospective study.Results Classifications:among the 86 neoplastic lesions(NL),there were 49

  11. 49 CFR 173.195 - Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution).

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Hydrogen cyanide, anhydrous, stabilized... Hazardous Materials Other Than Class 1 and Class 7 § 173.195 Hydrogen cyanide, anhydrous, stabilized (hydrocyanic acid, aqueous solution). (a) Hydrogen cyanide, anhydrous, stabilized, must be packed...

  12. Magnetic fluctuations in La1.95Ba0.05CuO4

    DEFF Research Database (Denmark)

    Hayden, S.M.; Aeppli, G.; Mook, H.;

    1991-01-01

    Neutron-scattering and resistivity experiments on single crystals of La1.95Ba0.05CuO4 are described. On warming to as high as 250 K, the correlation length does not change, and the temperature dependence of the generalized susceptibility chi(Q, omega) is due solely to the temperature dependence o...

  13. 49 CFR 195.573 - What must I do to monitor external corrosion control?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false What must I do to monitor external corrosion... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.573 What must I do to monitor external corrosion control? (a) Protected pipelines. You must do the following to...

  14. 49 CFR 195.583 - What must I do to monitor atmospheric corrosion control?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false What must I do to monitor atmospheric corrosion... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.583 What must I do to monitor atmospheric corrosion control? (a) You must inspect each pipeline or portion of pipeline that...

  15. 49 CFR 195.589 - What corrosion control information do I have to maintain?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false What corrosion control information do I have to... SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Corrosion Control § 195.589 What corrosion control... sufficient detail to demonstrate the adequacy of corrosion control measures or that corrosion...

  16. 49 CFR 195.563 - Which pipelines must have cathodic protection?

    Science.gov (United States)

    2010-10-01

    ... protection as a result of electrical inspections. See previous editions of this part in 49 CFR, parts 186 to... 49 Transportation 3 2010-10-01 2010-10-01 false Which pipelines must have cathodic protection? 195... have cathodic protection? (a) Each buried or submerged pipeline that is constructed,...

  17. The High Temperature Response of the TRACE 171 Angstrom and 195 Angstrom Channels

    Science.gov (United States)

    Phillips, K. J. H.; Chifor, C.; Landi, E.

    2005-01-01

    The CHIANTI spectral code is used to estimate line and continuum intensity contributions to the TRACE 171 Angstrom and 195 Angstrom channels, widely used for imaging a variety of solar features and phenomena, including quiet Sun and active region loops and solar flares. It is shown that the 171 Angstrom channel has a high-temperature response, so high-temperature (approx. 10 MK) features in flares, prominent in TRACE 195 approx.\\AA\\ images as well as X-ray images from Yohkoh and RHESSI, are sometimes visible in images made in the 171 Angstrom channel. Such features consist of hot loop-top emission, either confined spots or 'spine' structures in loop arcades. This is illustrated with TRACE and X-ray flare images.

  18. Removal of Chemazol Reactive Red 195 from aqueous solution by dehydrated beet pulp carbon.

    Science.gov (United States)

    Dursun, Arzu Y; Tepe, Ozlem

    2011-10-30

    An agricultural low-cost by-product, dehydrated beet pulp carbon (DBPC) was used as an adsorbent for removal of Chemazol Reactive Red 195 (CRR 195) from aqueous solution. The surface area of DBPC was measured as 9.5m(2)g(-1) by using BET method. The results indicated that adsorption was strongly pH-dependent and optimum pH was determined as 1.0. The maximum dye adsorption capacity was obtained as 58.0 mg g(-1)at the temperature of 50°C at this pH value. The Freundlich and Langmuir adsorption models were used for the mathematical description of the adsorption equilibrium and it was reported that, experimental data fitted very well to Freundlich model. Mass transfer and kinetic models were applied to the experimental data to examine the mechanisms of adsorption and potential rate-controlling steps. It was found that both external mass transfer and intra-particle diffusion played an important role in the adsorption mechanisms of dye and adsorption kinetics followed the pseudo-first-order type kinetic model. The thermodynamic parameters such as, Gibbs free energy changes (ΔG°), standard enthalpy change (ΔH°) and standard entropy change (ΔS°) had been determined. The results show that adsorption of CRR 195 on DBPC is endothermic and spontaneous in nature. PMID:21890269

  19. Predicting Pt-195 NMR chemical shift using new relativistic all-electron basis set.

    Science.gov (United States)

    Paschoal, D; Guerra, C Fonseca; de Oliveira, M A L; Ramalho, T C; Dos Santos, H F

    2016-10-01

    Predicting NMR properties is a valuable tool to assist the experimentalists in the characterization of molecular structure. For heavy metals, such as Pt-195, only a few computational protocols are available. In the present contribution, all-electron Gaussian basis sets, suitable to calculate the Pt-195 NMR chemical shift, are presented for Pt and all elements commonly found as Pt-ligands. The new basis sets identified as NMR-DKH were partially contracted as a triple-zeta doubly polarized scheme with all coefficients obtained from a Douglas-Kroll-Hess (DKH) second-order scalar relativistic calculation. The Pt-195 chemical shift was predicted through empirical models fitted to reproduce experimental data for a set of 183 Pt(II) complexes which NMR sign ranges from -1000 to -6000 ppm. Furthermore, the models were validated using a new set of 75 Pt(II) complexes, not included in the descriptive set. The models were constructed using non-relativistic Hamiltonian at density functional theory (DFT-PBEPBE) level with NMR-DKH basis set for all atoms. For the best model, the mean absolute deviation (MAD) and the mean relative deviation (MRD) were 150 ppm and 6%, respectively, for the validation set (75 Pt-complexes) and 168 ppm (MAD) and 5% (MRD) for all 258 Pt(II) complexes. These results were comparable with relativistic DFT calculation, 200 ppm (MAD) and 6% (MRD). © 2016 Wiley Periodicals, Inc.

  20. Sustainable syntrophic growth of Dehalococcoides ethenogenes strain 195 with Desulfovibrio vulgaris Hildenborough and Methanobacterium congolense: Global transcriptomic and proteomic analyses

    Energy Technology Data Exchange (ETDEWEB)

    Men, Y.; Feil, H.; VerBerkmoes, N.C.; Shah, M.B.; Johnson, D.R.; Lee, P.K.H; West, K.A.; Zinder, S.H.; Andersen, G.L.; Alvarez-Cohen, L.

    2011-03-01

    Dehalococcoides ethenogenes strain 195 (DE195) was grown in a sustainable syntrophic association with Desulfovibrio vulgaris Hildenborough (DVH) as a co-culture, as well as with DVH and the hydrogenotrophic methanogen Methanobacterium congolense (MC) as a tri-culture using lactate as the sole energy and carbon source. In the co- and tri-cultures, maximum dechlorination rates of DE195 were enhanced by approximately three times (11.0±0.01 lmol per day for the co-culture and 10.1±0.3 lmol per day for the tri-culture) compared with DE195 grown alone (3.8±0.1 lmol per day). Cell yield of DE195 was enhanced in the co-culture (9.0±0.5 x 107 cells per lmol Cl{sup -} released, compared with 6.8±0.9x 107 cells per lmol Cl{sup -} released for the pure culture), whereas no further enhancement was observed in the tri-culture (7.3±1.8x 107 cells per lmol Cl{sup -} released). The transcriptome of DE195 grown in the co-culture was analyzed using a whole-genome microarray targeting DE195, which detected 102 significantly up- or down-regulated genes compared with DE195 grown in isolation, whereas no significant transcriptomic difference was observed between co- and tri-cultures. Proteomic analysis showed that 120 proteins were differentially expressed in the co-culture compared with DE195 grown in isolation. Physiological, transcriptomic and proteomic results indicate that the robust growth of DE195 in co- and tri-cultures is because of the advantages associated with the capabilities of DVH to ferment lactate to provide H2 and acetate for growth, along with potential benefits from proton translocation, cobalamin-salvaging and amino acid biosynthesis, whereas MC in the tri-culture provided no significant additional benefits beyond those of DVH.

  1. Observation of double pygmy resonances in $^{195,196}$Pt and enhanced astrophysical reaction rates

    CERN Document Server

    Giacoppo, F; Eriksen, T K; Görgen, A; Guttormsen, M; Hagen, T W; Larsen, A C; Kheswa, B V; Klintefjord, M; Koehler, P E; Nyhus, H T; Renstr\\om, T; Sahin, E; Siem, S; Tornyi, T G

    2014-01-01

    Our measurements of $^{195,196}$Pt $\\gamma$-strength functions show a double-humped enhancement in the $E_{\\gamma}= 4-8$ MeV region. For the first time, the detailed shape of these resonances is revealed for excitation energies in the quasicontinuum. We demonstrate that the corresponding neutron-capture cross sections and astrophysical reaction rates are increased by up to a factor of 2 when these newly observed pygmy resonances are included. These results lend credence to theoretical predictions of enhanced reaction rates due to such pygmy resonances and hence are important for a better understanding of r-process nucleosynthesis.

  2. X-ray emission from the region of gamma 195 + 5

    International Nuclear Information System (INIS)

    X-ray emission from the vicinity of the MeV gamma ray source, gamma 195+5, was observed with the HEAO-A2 detectors. A source with an intensity of (1.5 +- 0.5) x 10-11 erg/cm2 s (2-6 keV) was seen in each of two separate observations at a combined confidence level of 3.1 sigma. The location of the source is l2 = 194.56 degrees, b2 = 4.92 degrees with a 90% confidence error box of 1.4 square degrees, significantly smaller than the positional uncertainty of the gamma ray source, and consistent with its location. The chance overlap of such an X-ray source with the gamma ray region is estimated to be 9% and, therefore, they may be 9% and therefore they may be associated. The spectrum appears too steep to extrapolate simply to the 100 MeV flux value for gamma 195+5

  3. Effects of adsorption interferents on removal of Reactive Red 195 dye in wastewater by chitosan

    Institute of Scientific and Technical Information of China (English)

    WEN Yue-zhong; LIU Wen-qi; FANG Zhao-hua; LIU Wei-ping

    2005-01-01

    Reactive Red 195, which is an azoic anionic dye characterized by the presence of five sulfonic groups and one azoic group, is efficiently removed using chitosan. The increasing chitosan dose had a dramatic positive impact on the achieved color removal, there was approximately a linear relationship between chitosan dose and color removal of dye before color removal reach maximum. Also, the increase of dye concentration led to the increase of chitosan dosage in order to get the same color removal. 92 mg/L of chitosan dosage was sufficient to achieve complete remove of dye at initial concentration of dye at 200 mg/L. For the higher concentrations of dye, high dosages were necessary to reach complete color removal. On the other hand, the use of adsorption interferents(Fe2+ , Na+ , HCO3- and others) can be interesting, addition of ions had effect on the color removal of Reactive Red 195. Comparing with blank, addition of chemical species approximately decreased the color removal except Na+ and combination of Fe2+ + HCO3-. However, comparing with Fe2+ alone and HCO3- alone, combination of Fe2+ + HCO-3 increased the color removal.

  4. Daily snow depth measurements from 195 stations in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Allison, L.J. [ed.] [Oak Ridge National Lab., TN (United States). Carbon Dioxide Information Analysis Center; Easterling, D.R.; Jamason, P.; Bowman, D.P.; Hughes, P.Y.; Mason, E.H. [National Oceanic and Atmospheric Administration, Asheville, NC (United States). National Climatic Data Center

    1997-02-01

    This document describes a database containing daily measurements of snow depth at 195 National Weather Service (NWS) first-order climatological stations in the United States. The data have been assembled and made available by the National Climatic Data Center (NCDC) in Asheville, North Carolina. The 195 stations encompass 388 unique sampling locations in 48 of the 50 states; no observations from Delaware or Hawaii are included in the database. Station selection criteria emphasized the quality and length of station records while seeking to provide a network with good geographic coverage. Snow depth at the 388 locations was measured once per day on ground open to the sky. The daily snow depth is the total depth of the snow on the ground at measurement time. The time period covered by the database is 1893--1992; however, not all station records encompass the complete period. While a station record ideally should contain daily data for at least the seven winter months (January through April and October through December), not all stations have complete records. Each logical record in the snow depth database contains one station`s daily data values for a period of one month, including data source, measurement, and quality flags.

  5. Biodegradation of C.I. Reactive Red 195 by Enterococcus faecalis strain YZ66.

    Science.gov (United States)

    Mate, Madhuri Sahasrabudhe; Pathade, Girish

    2012-03-01

    Synthetic dyes are extensively used in textile dyeing, paper, printing, colour photography, pharmaceutics, cosmetics and other industries. Among these, azodyes represents the largest and most versatile class of synthetic dyes. As high as 50% of the dyes are released into the environment during manufacture and usage. Traditional methods of treatment are found to be expensive and have operational problems. Biological decolourization has been investigated as a method to transform, degrade or mineralize azo dyes. In the present studies bacteria from soil from dye waste area, dye waste, sewage and dung were subjected to acclimatization with C.I. Reactive Red 195 an azo dye, in the basal nutrient media. The most promising bacterial isolate was used for further dye degradation studies. The 16s rRNA gene sequencing and biochemical characteristics revealed the isolated organism as Enterococcus faecalis strain YZ66. The strain showed 99.5% decolourization of the selected dye (Reactive Red 195-50 mg/l) within one and half hour in static anoxic condition. The optimum pH and temperature for the decolourization was 5.0 and 40°C respectively. The biodegradation was monitored by UV-Vis, FTIR, TLC and HPLC. The final products were characterized by Gas chromatography and Mass Spectrophotometry. Toxicity study demonstrated no toxicity of the biodegradation product. The results suggest that the isolated organism E. faecalis strain YZ 66 can be used as a useful tool to treat waste water containing reactive dyes.

  6. Observation of low-lying resonances in the quasicontinuum of 195,196Pt and enhanced astrophysical reaction rates

    Directory of Open Access Journals (Sweden)

    Giacoppo F.

    2015-01-01

    Full Text Available An excess of strength on the low-energy tail of the giant dipole resonance recently has been observed in the γ-decay from the quasicontinuum of 195,196Pt. The nature of this phenomenon is not yet fully investigated. If this feature is present also in the γ-ray strength of the neutron-rich isotopes, it can affect the neutron-capture reactions involved in the formation of heavy-elements in stellar nucleosynthesis. The experimental level density and γ-ray strength function of 195,196Pt are presented together with preliminary calculations of the corresponding neutron-capture cross sections.

  7. STS-33 MS Carter on KSC LC Pad 39B 195 ft level with OV-103 in background

    Science.gov (United States)

    1990-01-01

    STS-33 Mission Specialist (MS) Manley L. Carter, Jr, wearing launch and entry suit (LES), poses in front of Discovery, Orbiter Vehicle (OV) 103, at the 195 ft level elevator entrance at Kennedy Space Center (KSC) Launch Complex (LC) Pad 39B. Visible in the background is the catwalk to OV-103's side hatch and the Atlantic Ocean.

  8. 15 CFR 19.5 - How will Commerce entities add interest, penalty charges, and administrative costs to a Commerce...

    Science.gov (United States)

    2010-01-01

    ... administrative costs on Commerce debts in accordance with the provisions of 31 U.S.C. 3717 and 31 CFR 901.9... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false How will Commerce entities add... Debts § 19.5 How will Commerce entities add interest, penalty charges, and administrative costs to...

  9. 41 CFR 102-37.195 - Does a SASP have to have a donee in mind to request surplus property?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Does a SASP have to have...) Screening and Requesting Property § 102-37.195 Does a SASP have to have a donee in mind to request surplus property? Generally yes, you should have a firm requirement or an anticipated demand for any property...

  10. k195hw.m77t and k195hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-1-95-HW in in Hawaii from 06/14/1995 to 06/18/1995

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise K-1-95-HW. The cruise was conducted in Oahu,...

  11. STS-103 crew pose at 195-foot level of Fixed Service Structure

    Science.gov (United States)

    1999-01-01

    At the 195-foot level of the Fixed Service Structure on Launch Pad 39B, the STS-103 crew take a break from Terminal Countdown Demonstration Test (TCDT) activities. Standing from left to right are Mission Specialists Jean-Frangois Clervoy of France and Claude Nicollier of Switzerland, who are with the European Space Agency; Commander Curtis L. Brown Jr.; Pilot Scott J. Kelly; and Mission Specialists John M. Grunsfeld (Ph.D.), C. Michael Foale (Ph.D.) and Steven L. Smith. The TCDT provides the crew with the emergency egress training, opportunities to inspect their mission payloads in the orbiter's payload bay, and simulated countdown exercises. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope, including the gyroscopes that allow the telescope to point at stars, galaxies and planets. The STS-103 crew will be replacing a Fine Guidance Sensor, an older computer with a new enhanced model, an older data tape recorder with a solid-state digital recorder, a failed spare transmitter with a new one, and degraded insulation on the telescope with new thermal insulation. The crew will also install a Battery Voltage/Temperature Improvement Kit to protect the spacecraft batteries from overcharging and overheating when the telescope goes into a safe mode. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

  12. Equilibrium, kinetic and thermodynamic studies of the biosorption of textile dye (Reactive Red 195) onto Pinus sylvestris L

    International Nuclear Information System (INIS)

    This study investigated the biosorption of Reactive Red 195 (RR 195), an azo dye, from aqueous solution by using cone biomass of Pinus sylvestris Linneo. To this end, pH, initial dye concentration, biomass dosage and contact time were studied in a batch biosorption system. Maximum pH for efficient RR 195 biosorption was found to be 1.0 and the initial RR 195 concentration increased with decreasing percentage removal. Biosorption capacity increased from 6.69 mg/g at 20 deg. C to 7.38 mg/g at 50 deg. C for 200 mg/L dye concentration. Kinetics of the interactions was tested by pseudo-first-order and pseudo-second-order kinetics, the Elovich equation and intraparticle diffusion mechanism. Pseudo-second-order kinetic model provided a better correlation for the experimental data studied in comparison to the pseudo-first-order kinetic model and intraparticle diffusion mechanism. Moreover, the Elovich equation also showed a good fit to the experimental data. Freundlich and Langmuir adsorption isotherms were used for the mathematical description of the biosorption equilibrium data. The activation energy of biosorption (Ea) was found to be 8.904 kJ/mol by using the Arrhenius equation. Using the thermodynamic equilibrium coefficients obtained at different temperatures, the study also evaluated the thermodynamic constants of biosorption (ΔGo, ΔHo and ΔS). The results indicate that cone biomass can be used as an effective and low-cost biosorbent to remove reactive dyes from aqueous solution.

  13. Expression of Reductive Dehalogenase Genes in Dehalococcoides ethenogenes Strain 195 Growing on Tetrachloroethene, Trichloroethene, or 2,3-Dichlorophenol▿ †

    OpenAIRE

    Fung, Jennifer M.; Morris, Robert M.; Adrian, Lorenz; Zinder, Stephen H.

    2007-01-01

    Reductive dehalogenase (RD) gene transcript levels in Dehalococcoides ethenogenes strain 195 were investigated using reverse transcriptase quantitative PCR during growth and reductive dechlorination of tetrachloroethene (PCE), trichloroethene (TCE), or 2,3-dichlorophenol (2,3-DCP). Cells grown with PCE or TCE had high transcript levels (greater than that for rpoB) for tceA, which encodes the TCE RD, pceA, which encodes the PCE RD, and DET0162, which contains a predicted stop codon and is cons...

  14. Early hominin diet included diverse terrestrial and aquatic animals 1.95 Ma in East Turkana, Kenya

    OpenAIRE

    Braun, David R.; Harris, John W. K.; Naomi E. Levin; McCoy, Jack T.; Herries, Andy I. R.; Bamford, Marion K.; Bishop, Laura C.; Richmond, Brian G.; Kibunjia, Mzalendo

    2010-01-01

    The manufacture of stone tools and their use to access animal tissues by Pliocene hominins marks the origin of a key adaptation in human evolutionary history. Here we report an in situ archaeological assemblage from the Koobi Fora Formation in northern Kenya that provides a unique combination of faunal remains, some with direct evidence of butchery, and Oldowan artifacts, which are well dated to 1.95 Ma. This site provides the oldest in situ evidence that hominins, predating Homo erectus, enj...

  15. VizieR Online Data Catalog: Radio fluxes of 195 ICRF2-Gaia transfer sources (Le Bail+, 2016)

    Science.gov (United States)

    Le Bail, K.; Gipson, J. M.; Gordon, D.; MacMillan, D. S.; Behrend, D.; Thomas, C. C.; Bolotin, S.; Himwich, W. E.; Baver, K. D.; Corey, B. E.; Titus, M.; Bourda, G.; Charlot, P.; Collioud, A.

    2016-07-01

    The second realization of the International Celestial Reference Frame (ICRF2) is based on Very Long Baseline Interferometry (VLBI) data at radio frequencies in X band and S band. The European Space Agency's Gaia mission, launched on 2013 December 19, started routine scientific operations in 2014 July. By scanning the whole sky, it is expected to observe ~500000 Quasi Stellar Objects in the optical domain. This means that, in the future, two extragalactic celestial reference frames, at two different frequency domains, will coexist. It will thus be important to align them very accurately. In 2012, the Laboratoire d'Astrophysique de Bordeaux (LAB) selected 195 sources from ICRF2 that will be observed by Gaia and should be suitable for aligning the radio and optical frames: they are called ICRF2-Gaia transfer sources. The LAB submitted a proposal to the International VLBI Service (IVS) to regularly observe these ICRF2-Gaia transfer sources at the same rate as Gaia observes them in the optical realm, e.g., roughly once a month. Of the 195 sources, all but one have been successfully observed in the 12 months prior to 2015 September 01. Table1 lists the 195 ICRF2-Gaia transfer sources. Beginning in 2003 June, the Goddard VLBI group developed a program to purposefully monitor when sources were observed and to increase the observations of "under-observed" sources. In 2013 March, we added all 195 ICRF2-Gaia transfer sources to the IVS source monitoring program with an observation target of 12 successful sessions per year. (1 data file).

  16. ["The Italian decree 195/2006 on the protection of workers against risks arising from noise"].

    Science.gov (United States)

    Merluzzi, F; Pira, E; Riboldi, L

    2006-01-01

    The Italian decree 195/2006 incorporates the European Directive 2003/10/CE on the minimum health and safety requirements regarding the exposure of workers to the risks arising from physical agents (noise). It is rather different to previous decree 277/1991, particularly as regard of the new exposure limit value and the elimination of annex VI and VII. We discus here only two aspects that we consider relevant and quite critical: 1) The calculation of the exposure limit values as noise equivalent level: it is a method that underestimates the potential damage of impulsive noise, so the risk evaluation remains quite inaccurate. 2) To take account of the attenuation provided by the individual hearing protectors worn by the worker in determining the worker's effective exposure when applying the exposure limit values: this must not apply to the obligations of employer to control the risk at source avoiding or reducing exposure to the minimum. Furthermore the attenuation power of individual hearing protectors is difficult to measure because his variability during the time and among different subjects. Then we evaluate and discus the new duties of Occupational Physician in this matter. The daily exposure limit values and action values are in fact in part modified as well as the methodology for organize the programs of prevention, health surveillance, information and formation of workers. As support for his activity we proposed the guidelines that The Italian Society of Occupational Health and Industrial Hygiene (SIMLII) has published in 2003, which provides recommendations for the health surveillance for the prevention of noise induced hearing loss at the workplace. PMID:17144410

  17. Patient-reported outcomes of parenteral somatostatin analogue injections in 195 patients with acromegaly

    Science.gov (United States)

    Strasburger, Christian J; Karavitaki, Niki; Störmann, Sylvère; Trainer, Peter J; Kreitschmann-Andermahr, Ilonka; Droste, Michael; Korbonits, Márta; Feldmann, Berit; Zopf, Kathrin; Sanderson, Violet Fazal; Schwicker, David; Gelbaum, Dana; Haviv, Asi; Bidlingmaier, Martin; Biermasz, Nienke R

    2016-01-01

    Background Long-acting somatostatin analogues delivered parenterally are the most widely used medical treatment in acromegaly. This patient-reported outcomes survey was designed to assess the impact of chronic injections on subjects with acromegaly. Methods The survey was conducted in nine pituitary centres in Germany, UK and The Netherlands. The questionnaire was developed by endocrinologists and covered aspects of acromegaly symptoms, injection-related manifestations, emotional and daily life impact, treatment satisfaction and unmet medical needs. Results In total, 195 patients participated, of which 112 (57%) were on octreotide (Sandostatin LAR) and 83 (43%) on lanreotide (Somatuline Depot). The majority (>70%) of patients reported acromegaly symptoms despite treatment. A total of 52% of patients reported that their symptoms worsen towards the end of the dosing interval. Administration site pain lasting up to a week following injection was the most frequently reported injection-related symptom (70% of patients). Other injection site reactions included nodules (38%), swelling (28%), bruising (16%), scar tissue (8%) and inflammation (7%). Injection burden was similar between octreotide and lanreotide. Only a minority of patients received injections at home (17%) and 5% were self-injecting. Over a third of patients indicated a feeling of loss of independence due to the injections, and 16% reported repeated work loss days. Despite the physical, emotional and daily life impact of injections, patients were satisfied with their treatment, yet reported that modifications that would offer major improvement over current care would be ‘avoiding injections’ and ‘better symptom control’. Conclusion Lifelong injections of long-acting somatostatin analogues have significant burden on the functioning, well-being and daily lives of patients with acromegaly. PMID:26744896

  18. TGF-β1 regulating miR-205/miR-195 expression affects the TGF-β signal pathway by respectively targeting SMAD2/SMAD7.

    Science.gov (United States)

    Duan, Yingjun; Chen, Qianxue

    2016-10-01

    Transforming growth factor-β (TGF-β) proteins are important cytokines in the occurrence and development of tumors. However, its neural functions in glioma are still not understood. In the present study, we evaluated the effects of TGF-β1 on glioma cell line U87. miR-205 and miR-195 were involved in TGF-β1 signaling pathway. Quantitative real-time PCR was used to detect miR-205 and miR-195 levels in human glioma tissue samples and U87 cells treated with different concentrations of TGF-β1. Enzyme-linked immunosorbent assay (ELISA) was performed to determine TGF-β1 in the glioma patients peripheral blood. In vitro, U87 cells were transfected with mimics or inhibitors of miR-205 and miR-195. SMAD proteins were assayed by western blotting. Luciferase assay and co-immunoprecipitation (Co-IP)were used to determine the relationships between miR-205 and SMAD2, miR-195 and SMAD7. Effects of miR-205 and miR-195 on glioma cell proliferation and invasion using colony forming and cell migration assays. It was shown that miR-205 was decreased in glioma tissue, but miR-195 and TGF-β1 was increased. In addition, TGF-β1 concentration was negatively correlated with miR-205 mRNA level, but positively correlated with miR-195 mRNA. In addition, miR-205 was downregulated and miR-195 was upregulated by TGF-β1 in a dose-dependent manner. miR-205 and miR-195 targeted and inhibited SMAD2 and SMAD7 expression, respectively, in U87. High expression of miR-205 but not miR-195 reduced SMAD2 and SMAD4 heteromer formation. In addition, it was also shown that miR-205 overexpression inhibited U87 proliferation and invasion efficiently. All the results suggested that miR-205 and miR-195 participated in the TGF-β1 signaling pathway and showed opposite effects in glioma. These findings contribute to the understanding of TGF-β1 function in glioma.

  19. MicroRNA-195 inhibits the proliferation of human glioma cells by directly targeting cyclin D1 and cyclin E1.

    Directory of Open Access Journals (Sweden)

    Wang Hui

    Full Text Available Glioma proliferation is a multistep process during which a sequence of genetic and epigenetic alterations randomly occur to affect the genes controlling cell proliferation, cell death and genetic stability. microRNAs are emerging as important epigenetic modulators of multiple target genes, leading to abnormal cellular signaling involving cellular proliferation in cancers.In the present study, we found that expression of miR-195 was markedly downregulated in glioma cell lines and human primary glioma tissues, compared to normal human astrocytes and matched non-tumor associated tissues. Upregulation of miR-195 dramatically reduced the proliferation of glioma cells. Flow cytometry analysis showed that ectopic expression of miR-195 significantly decreased the percentage of S phase cells and increased the percentage of G1/G0 phase cells. Overexpression of miR-195 dramatically reduced the anchorage-independent growth ability of glioma cells. Furthermore, overexpression of miR-195 downregulated the levels of phosphorylated retinoblastoma (pRb and proliferating cell nuclear antigen (PCNA in glioma cells. Conversely, inhibition of miR-195 promoted cell proliferation, increased the percentage of S phase cells, reduced the percentage of G1/G0 phase cells, enhanced anchorage-independent growth ability, upregulated the phosphorylation of pRb and PCNA in glioma cells. Moreover, we show that miR-195 inhibited glioma cell proliferation by downregulating expression of cyclin D1 and cyclin E1, via directly targeting the 3'-untranslated regions (3'-UTR of cyclin D1 and cyclin E1 mRNA. Taken together, our results suggest that miR-195 plays an important role to inhibit the proliferation of glioma cells, and present a novel mechanism for direct miRNA-mediated suppression of cyclin D1 and cyclin E1 in glioma.

  20. Preparation and electrochemical properties of LiMn1.95M0.05O4 (M = Cr, Ni)

    Institute of Scientific and Technical Information of China (English)

    YU Zemin; ZHAO Liancheng

    2007-01-01

    The preparation process and electrochemical properties of LiMn2O4 and LiMn1.95M0.05O4 (M = Cr, Ni) were studied.The results show that the decomposition temperature range of xerogel prepared with lithium acetate and manganese acetate as raw materials is large and the decomposition speed is slow.Oxygen consumed is apt to get a prompt supplement during the preparation of LiMn2O4,and carbonization of the organic matter can be reduced or avoided,which is favorable to the combination of lithium and manganese.Using lithium acetate,manganese acetate, chromium nitrate,and nickel nitrate as raw materials and adopting the citric acid complexing method,it has been found that the prepared powders have high purity,high quality stability,and even doping characters. With the increase of sintering temperature,the particle size and crystal lattice constant of LiMn1.95M0.05O4 (M = Cr, Ni) enhance.However,the purity of the product is relatively high and has no obvious change,which is advantageous to the control of the quality of LiMn1.95M0.05O4 (M = Cr, NJ).Doping with a small amount of Cr3+ and Ni2+ can stabilize the spinel structure of LiMn2O4,suppress the Jahn-Teller effect,and improve the cycling properties but reduce the initial capacity.

  1. Identification of a novel HLA-A allele, HLA-A*01:195, in a UAE national.

    Science.gov (United States)

    Abdrabou, Wael; Witzel, Ini-Isabée; Paduch, Agnieszka; Tay, Guan; Alsafar, Habiba

    2016-07-01

    A novel human leucocyte antigen (HLA)-A allele, HLA-A*01:195, was identified by sequence-based typing (SBT) in a UAE national subject. The novel allele is identical to its closest known allele, HLA-A*01:01:01:01, in exon 2, 3 and 4, except for a single nucleotide mutation of A to G at position 442 in exon 3 (codon 124 in the α2 domain of the α chain of the mature protein). This A to G mutation results in an amino acid change of isoleucine #124 to valine. PMID:27184862

  2. Eta photoproduction on the proton for photon energies from 0.75 to 1.95 GeV.

    Science.gov (United States)

    Dugger, M; Ritchie, B G; Ball, J; Pasyuk, E; Adams, G; Anciant, E; Anghinolfi, M; Asavapibhop, B; Audit, G; Auger, T; Avakian, H; Bagdasaryan, H; Barrow, S; Battaglieri, M; Beard, K; Bektasoglu, M; Bellis, M; Berman, B L; Bianchi, N; Biselli, A S; Boiarinov, S; Bouchigny, S; Bradford, R; Branford, D; Briscoe, W J; Brooks, W K; Burkert, V D; Calarco, J R; Capitani, G P; Carman, D S; Carnahan, B; Cetina, C; Clark, R; Cole, P L; Coleman, A; Connelly, J; Cords, D; Corvisiero, P; Crabb, D; Crannell, H; Cummings, J P; DeSanctis, E; DeVita, R; Degtyarenko, P V; Denizli, H; Dennis, L; Dharmawardane, K V; Dhuga, K S; Djalali, C; Dodge, G E; Doughty, D; Dragovitsch, P; Dytman, S; Eckhause, M; Egiyan, H; Egiyan, K S; Elouadrhiri, L; Farhi, L; Fatemi, R; Feldman, G; Feuerbach, R J; Ficenec, J; Forest, T A; Frolov, V; Funsten, H; Gaff, S J; Gai, M; Gavalian, G; Gilad, S; Gilfoyle, G P; Giovanetti, K L; Girard, P; Gordon, C I O; Griffioen, K; Guidal, M; Guillo, M; Guo, L; Gyurjyan, V; Hadjidakis, C; Hancock, D; Hardie, J; Heddle, D; Heimberg, P; Hersman, F W; Hicks, K; Hicks, R S; Holtrop, M; Hyde-Wright, C E; Ito, M M; Jenkins, D; Joo, K; Kelley, J H; Kellie, J D; Khandaker, M; Kim, W; Klein, A; Klein, F J; Klusman, M; Kossov, M; Koubarovski, V; Kramer, L H; Kuang, Y; Kuhn, S E; Kuhn, J; Lachniet, J; Laget, J M; Lawrence, D; Li, Ji; Livingston, K; Longhi, A; Lucas, M; Lukashin, K; Major, W; Manak, J J; Marchand, C; McAleer, S; McCarthy, J; McNabb, J W C; Mecking, B A; Mehrabyan, S; Mestayer, M D; Meyer, C A; Mikhailov, K; Minehart, R; Mirazita, M; Miskimen, R; Morand, L; Morrow, S A; Mozer, M U; Muccifora, V; Mueller, J; Murphy, L Y; Mutchler, G S; Napolitano, J; Nasseripour, R; Nelson, S O; Niccolai, S; Niculescu, G; Niculescu, I; Niczyporuk, B B; Niyazov, R A; Nozar, M; O'Brien, J T; O'Rielly, G V; Opper, A K; Park, K; Peterson, G; Philips, S A; Pivnyuk, N; Pocanić, D; Pogorelko, O; Polli, E; Pozdniakov, S; Preedom, B M; Price, J W; Prok, Y; Protopopescu, D; Qin, L M; Raue, B A; Riccardi, G; Ricco, G; Ripani, M; Ronchetti, F; Rossi, P; Rowntree, D; Rubin, P D; Sabatié, F; Sabourov, K; Salgado, C; Santoro, J P; Sanzone-Arenhovel, M; Sapunenko, V; Schumacher, R A; Serov, V S; Shafi, A; Sharabian, Y G; Shaw, J; Skabelin, A V; Smith, E S; Smith, T; Smith, L C; Sober, D I; Spraker, M; Stavinsky, A; Stepanyan, S; Stoler, P; Strakovsky, I I; Strauch, S; Taiuti, M; Taylor, S; Tedeschi, D J; Thoma, U; Thompson, R; Todor, L; Ungaro, M; Vineyard, M F; Vlassov, A V; Wang, K; Weinstein, L B; Weller, H; Weygand, D P; Whisnant, C S; Witkowski, M; Wolin, E; Wood, M H; Yegneswaran, A; Yun, J; Zhang, B; Zhao, J; Zhou, Z

    2002-11-25

    Differential cross sections for gammap-->etap have been measured with tagged real photons for incident photon energies from 0.75 to 1.95 GeV. Mesons were identified by missing mass reconstruction using kinematical information for protons scattered in the production process. The data provide the first extensive angular distribution measurements for the process above W=1.75 GeV. Comparison with preliminary results from a constituent quark model support the suggestion that a third S11 resonance with mass approximately 1.8 GeV couples to the etaN channel. PMID:12485062

  3. Characterization of Ce0.9Gd0.1O1.95 powders synthesized by spray drying

    DEFF Research Database (Denmark)

    Blennow Tullmar, Peter; Chen, Weiwu; Lundberg, Mats;

    2009-01-01

    Ce0.9Gd0.1O1.95 powders were synthesized by spray drying and successive calcinations. The phase purity, BET surface area, and particle morphology of as-sprayed and calcined powders were characterized. After calcination above 300 °C, the powders were single phase and showed a BET surface area of 68...... m2/g when calcined at 300 °C. The conductivity, in air, of sintered pellets was measured by electrochemical impedance spectroscopy (EIS) and it was found to be comparable with literature values. The activation energy for the total conductivity was around 0.83 eV. The powder calcined at lower...

  4. The expression of miR-195 in esophageal cancer and its effect on proliferation of esophageal cancer cell lines%miR-195在食管癌中的表达及其对食管癌细胞株增殖的影响

    Institute of Scientific and Technical Information of China (English)

    傅敏根; 李硕; 郁婷婷; 钱丽娟; 高树娟; 朱宏; 冯亚东; 曹日昇; 陈亮

    2013-01-01

    目的:探讨microRNA-195 (miR-195)在食管癌中的表达及其对食管鳞癌细胞Eca109增殖的影响.方法:采用Taqman探针实时定量PCR方法检测10对外科手术食管鳞癌标本miR-195的表达,用阳离子脂质体LipofectamineTM2000将miR-195类似物转染入Eca109细胞,Cell Counting Kit-8(CCK-8)法检测细胞增殖情况,流式细胞仪检测细胞周期,Western blot 检测蛋白表达水平.结果:与正常食管上皮相比,食管鳞癌组织miR-195表达明显降低(P<0.05).在48、72、96 h,miR-195转染组细胞吸光值明显低于对照组(P<0.05),且miR-195转染组处于G0/G1期细胞的百分数明显高于对照组(P<0.05).Western blot结果显示miR-195转染组Cdc42蛋白水平明显低于对照组(P<0.05).结论:miR-195可阻滞Eca109细胞从G1期进入S期,抑制其增殖.%Objective:To observe the expression of microRNA-195 (miR-195) in ESCC tissues and the effects of miR-195 on the proliferation of Eca109 cells.Methods:The expression of miR-195 in ten pairs of ESCC tumor tissues and adjacent normal esophageal tissues after surgical resection was detected by Taqman Real-time PCR.The miR-195 mimics was transfected into Eca109 cell by using LipofectamineTM 2000.The ability of cell proliferation and cell cycle were detected by Cell Counting Kit-8 (CCK-8)and FACS,respectively.Protein was detected by Western Blot.Results:The miR-195 was down-regulated in ESCC tissues compared with normal esophageal tissues (P < 0.05).After transfected miR-195 mimics,cell proliferation was inhibited by CCK-8 assay and cell cycle was arrested in G0/G1 phase by FACS assay (P < 0.01).Western blot result indicated that Cdc42 protein was reduced after miR-195 mimics transfected (P < 0.01).Conclusion:The miR-195 could induce G1 arrest and inhibit proliferation in Eca109.

  5. Analyses of Finite Element and Experimental Mode for Cylinder Block of Type 195 Diesel%S195柴油机机体的有限元分析和试验模态分析

    Institute of Scientific and Technical Information of China (English)

    赵伟敏; 杨超珍

    2001-01-01

    The dynamic characteristic analysis for cylinder block of S195 diesel engine is performed by use of dynamic finite element and e xperimental modal analysis. The results about natural frequency and modal shape in the finite element analysis and modal analysis are almost equal. Through defo rmation data analysis of forced response simulation on the block struction the t rouble mechanism is found. The results show that predicting the dynamic characte ristic and deformation by finite element analysis is reliable and efficient.%应用动态有限元和试验模态分析技术研究S195柴油机 机体的动 态特性,从固有频率和振型两个方面比较两种方法的分析结果,两者基本一致。通过结构的 受迫响应模拟,从各部分变形数据分析实际使用中的故障机理,结果表明:利用有限元分析 技术预测机体结构的动态特性和变形,可靠有效。

  6. Absorption cross section measurements of oxygen in the wavelength region 195-241 nm of the Herzberg continuum

    Science.gov (United States)

    Cheung, A. S.-C.; Yoshino, K.; Parkinson, W. H.; Freeman, D. E.; Guberman, S. L.

    1986-01-01

    The continuous absorption cross section of oxygen in the region 205-241 nm is studied as a function of path length and oxygen pressure. The technique used to study the continuous absorption cross section is described. Cross section measurements of oxygen in the wavelength region 193-205 nm obtained by Cheung et al. (1984) are applied in this experiment. The measured cross section is analyzed in terms of a Herzberg continuum and a pressure-dependent continuum. The total measured continuum cross section, the cross section involving two molecules of O2, and the Herzberg continuum absorption cross section values are calculated. It is observed that the Herzberg continuum cross section of oxygen values measured at 1 nm intervals in the region 195-241 nm, increase from 6.3 x 10 to the -24th sq cm at 195 nm to a maximum of 6.6 x 10 to the -24th sq cm at 201 nm and then decrease to 0.85 x 10 to the -24th sq cm at 241 nm. The Herzberg values are compared with data from previous investigations and the values correlate well.

  7. 1H and 195Pt NMR Study of the Parallel Two-Chain Compound Per2[Pt(mnt2

    Directory of Open Access Journals (Sweden)

    Elizabeth L. Green

    2012-08-01

    Full Text Available 1H and 195Pt NMR are used to probe the spin ½ anion chain in the quasi-one-dimensional conductor Per2[Pt(mnt2], which exhibits nearly simultaneous charge density wave (CDW and spin-Peierls (SP transitions at low temperatures (Tc ~ 8 K. Below Tc the [Pt(mnt2] chain forms a spin-singlet state that is evident in 1H NMR spectra and spin relaxation (1/T1 rates; however minority unpaired Pt spins may remain in the SP ground state. With increasing magnetic field, the SP and CDW order parameters decrease in unison, indicating they are coupled up to a critical field Bc ~ 20 T. Above Bc, the spin singlet evolves into a spin-polarized configuration. The 195Pt NMR signals vanish as either Tc or Bc are approached from within the SP ground state, suggesting the hyperfine field of the Pt nucleus is significantly stronger than at the proton sites. Simulations yield a consistent picture of the angular, temperature, and magnetic field-dependent spectral features.

  8. Novel approaches to animal and human pharmacology: Pharmacokinetic imaging with 195mPt-cisplatin and 195mPt-carboplatin and correlative functional imaging of the pathophysiological status of tumors

    International Nuclear Information System (INIS)

    Pharmacokinetic imaging (the measurement of the time course of a drug at a target site), when combined with functional imaging (the measurement of the functional properties of the host's target site), provide the key elements needed to understand whether a drug can reach its desired target site (tumor) and whether it will do so at rates and in amounts that will make that drug effective in that individual. We have now developed a method that allows for the concurrent measurement of all the three spaces of tumors: the cellular space can be studied by using the 195mPt-labeled drugs, the vascular space by using 99mTc-RBC's and the sum of all extracellular spaces by using 111In-DTPA. Performing such imaging studies in such an order allows for concurrent measurements, in as much as the energy window of the gamma camera can be moved from 195mPt (mostly 66-77 keV) to 99mTc (centred on 141 keV) to 111In (energies above 180 keV). Studies in an animal tumor model have shown that the parameters of cisplatin or of carboplatin can be estimated from the imaging data following administration of the 195mPt-labeled drugs. As a next step, the functional status of tumors is of particular importance, given that changes in the tumour's pathophysiology will modify greatly the ability of drugs to be delivered to that target site - and hence, to be effective as antitumour agents. This is especially critical for drugs whose tumor targeting is governed by first passage phenomena, such as cisplatin and 5-FU, but very different for drugs whose targeting is governed by slow diffusion processes. These functional studies allow the direct measurement of the relative contributions that the well vascularized regions, the poorly vascularized regions, and the non-vascularized regions will make in allowing drugs to be targeted to tumor cells, as well as of the relative proportion of the vascular and the IF spaces in such regions. A new approach to chemotherapeutic planning is proposed: the use of

  9. Estoma & câncer retal: revisão de 195 estomas realizados em 380 pacientes portadores de câncer retal Stoma and rectal cancer: review of 195 stomas carried out in 380 patients with rectal cancer

    Directory of Open Access Journals (Sweden)

    Geraldo Magela Gomes da Cruz

    2008-06-01

    Full Text Available Em uma casuística de 24.000 pacientes 923 eram portadores de tumores de intestino grosso (3.8%, 870 dos quais eram tumores colorretais (94,2%, dos quais 490 eram câncer no cólon (53,1% e 380 no reto (41,2% e apenas 53 tumores anais (5,7%. O objetivo deste trabalho é estudar 380 pacientes portadores de câncer retal, analisando, especificamente, os 195 estomas criados nos mesmos, estratificando-os em temporários e definitivos, descrevendo suas modalidades e indicações bem como suas complicações e abordagem cirúrgicas das mesmas. De 380 pacientes portadores de câncer retal 373 foram operados (98,2% e 338 tiveram os tumores removidos (91,8%, tendo sido a retossigmoidectomia abdominal a técnica cirúrgica mais realizada (172 ou 45,3%, das quais, 133 com anastomose manual (35,0% e 39 com anastomose mecânica (10,3%, seguida pela amputação abdominoperineal (135 casos ou 35,5%. Dos 373 pacientes operados foram realizados estomas em 195 (52,3%, 174 dos quais definitivos (46,6% e 21 temporários (5,7%. Destarte, dos 195 estomas realizados, 174 foram definitivos (89,2% e 21 temporários (10,8%. As modalidades de estomas mais realizados foram colostomias terminais (146 casos, 39,1% e colostomias em alça (30 casos, 8,0%. Dos 21 estomas temporários nove foram colostomias em alça (5,2% e 12 foram ileostomias em alça (7,0%. Em 16 dos 21 casos o estoma foi feito como protetor de anastomose em 133 casos de ressecção com anastomose manual (oito colostomias em alça e oito ileostomias em alça; e cinco foram realizados em 39 casos de anastomoses mecânicas, sendo uma colostomia em alça e quatro ileostomias em alça. Os 174 estomas definitivos foram feitos em 135 casos de amputação abdominoperineal, 35 em tumores irressecáveis e quatro em proctocolectomia, tendo sido 146 colostomias terminais (83,9%, quatro ileostomias terminais (2,3%, 21 colostomias em alça (12,1% e três colostomias duplas (1,7%. Ocorreram 14 complicações (7,2% nos 195

  10. Research on rapeseed oil as an alternative fuel in the S195 type diesel engine%S195柴油机燃用菜籽油的试验

    Institute of Scientific and Technical Information of China (English)

    陈军; 师帅兵; 韩冰; 张娟利; 卢红春

    2001-01-01

    Using rapeseed oil as the fuel,the fuel performance of S195 type diesel engine was studied.It indicated that it is feasible to burn rapeseed oil or mixture of rapeseed oil and diesel oil without changing the structure of the engine;When burning the rapeseed oil or the mixture fuel in the engine,the exhaust pollution is on decline,but the specific fuel consumption rate and deposit charcoal of combustion chambers and injection nozzles are more than ever.The performance of the engine is rather good when burning the mixture of half rapeseed oil and half light diesel oil in volume and the angle of pre-oil-supplied be 20° CA.%以菜籽油为燃料,对S195柴油机燃油性能进行了研究。结果表明:在发动机结构不经改动的情况下,燃用菜籽油或菜籽油与柴油的混合油是可行的;发动机燃用菜籽油或混合油时,其排放污染下降,但耗油率均有所上升,且燃烧室和喷油嘴积炭较多;发动机燃用50%菜籽油与50%轻柴油的混合油,且供油提前角为20° CA时燃烧性能较好。

  11. Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma.

    Science.gov (United States)

    Liu, Ying; Wu, Xin; Gao, Yuan; Zhang, Jigang; Zhang, Dandan; Gu, Shengying; Zhu, Guanhua; Liu, Gaolin; Li, Xiaoyu

    2016-01-01

    Liver cancer is the fifth most commonly diagnosed malignancy, of which hepatocellular carcinoma (HCC) represents the dominating histological subtype. Antiangiogenic therapy aimed at vascular endothelial growth factor (VEGF) has shown promising but deficient clinical prospects on account of vasculogenic mimicry, a highly patterned vascular channel distinguished from the endothelium-dependent blood vessel, which may function as blood supply networks occurring in aggressive tumors including HCC. In this study, we used a new cationic peptide, disulfide cross-linked stearylated polyarginine peptide modified with histidine (H3R5), as a reducible vector, cell penetrating peptide-modified aptamer (ST21) with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe, miRNA-195 (miR195) as a powerful gene drug to inhibit VEGF, and fasudil to suppress vasculogenic mimicry by blocking ROCK2, all of which were simultaneously encapsulated in the same nanoparticles. Fasudil was loaded by ammonium sulfate-induced transmembrane electrochemical gradient and miR195 was condensed through electrostatic interaction. ST21-H3R5-polyethylene glycol (PEG) exhibited excellent loading capacities for both fasudil and miR195 with adjustable dosing ratios. Western blot analysis showed that (Fasudil)ST21-H3R5-PEGmiR195 had strong silencing activity of ROCK2 and VEGF, as compared with (Fasudil)H3R5-PEGmiR195. In vitro and in vivo experiments confirmed that ST21-modified nanoparticles showed significantly higher cellular uptake and therapeutic efficacy in tumor cells or tumor tissues than the unmodified counterparts. These findings suggest that aptamer-conjugated peptide holds great promise for delivering chemical drugs and gene drugs simultaneously to overcome HCC. PMID:27574422

  12. Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma

    Science.gov (United States)

    Liu, Ying; Wu, Xin; Gao, Yuan; Zhang, Jigang; Zhang, Dandan; Gu, Shengying; Zhu, Guanhua; Liu, Gaolin; Li, Xiaoyu

    2016-01-01

    Liver cancer is the fifth most commonly diagnosed malignancy, of which hepatocellular carcinoma (HCC) represents the dominating histological subtype. Antiangiogenic therapy aimed at vascular endothelial growth factor (VEGF) has shown promising but deficient clinical prospects on account of vasculogenic mimicry, a highly patterned vascular channel distinguished from the endothelium-dependent blood vessel, which may function as blood supply networks occurring in aggressive tumors including HCC. In this study, we used a new cationic peptide, disulfide cross-linked stearylated polyarginine peptide modified with histidine (H3R5), as a reducible vector, cell penetrating peptide-modified aptamer (ST21) with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe, miRNA-195 (miR195) as a powerful gene drug to inhibit VEGF, and fasudil to suppress vasculogenic mimicry by blocking ROCK2, all of which were simultaneously encapsulated in the same nanoparticles. Fasudil was loaded by ammonium sulfate-induced transmembrane electrochemical gradient and miR195 was condensed through electrostatic interaction. ST21-H3R5-polyethylene glycol (PEG) exhibited excellent loading capacities for both fasudil and miR195 with adjustable dosing ratios. Western blot analysis showed that FasudilST21-H3R5-PEGmiR195 had strong silencing activity of ROCK2 and VEGF, as compared with FasudilH3R5-PEGmiR195. In vitro and in vivo experiments confirmed that ST21-modified nanoparticles showed significantly higher cellular uptake and therapeutic efficacy in tumor cells or tumor tissues than the unmodified counterparts. These findings suggest that aptamer-conjugated peptide holds great promise for delivering chemical drugs and gene drugs simultaneously to overcome HCC. PMID:27574422

  13. Double-neutron capture reaction and natural abundance of 183W, 195Pt and 199Hg isotopes

    Science.gov (United States)

    Karamian, S. A.; Aksenov, N. V.; Bozhikov, G. A.

    2016-06-01

    There are much data on neutron cross sections over the chart of nuclides for stable isotopes and not as much for the radioactive ones. Double neutron capture experiments could be fruitful to provide more data. Time-integrated mean flux of slow neutrons reaches the value of 2.3-1012 n/cm2 s at the irradiation port near the active zone of the IBR-2 pulsed reactor of JINR. This is enough to detect the double neutron capture products by the activation method. A high capture cross section is obtained in the present experiment for intermediate radioactive 182Ta and 194Ir target nuclides. Together with the known data for 198Au, these values may prove an essential role of double neutron capture process for nucleosynthesis of 183W, 195Pt and 199Hg isotopes at stellar conditions.

  14. Conversion electron measurements of 195Au using ICEBall for Nuclear Structure and Astrophysics at the University of Notre Dame

    Science.gov (United States)

    Battaglia, Anthony; Tan, Wanpeng; Aprahamian, Ani; Bauder, William; Casarella, Clark; Gurdal, Gulhan; Long, Alexander; Nystrom, Andrew; Siegl, Kevin; Smith, Karl; Smith, Mallory

    2013-10-01

    The Internal Conversion Electron Ball Array (ICEBall) consists of six Si(Li) detectors and it was recently re-comissioned at the University of Notre Dame Nuclear Science Laboratory for spectroscopic studies of heavy nuclei. For the commissioning experiment, a 16 MeV bunched proton beam was used from the FN Tandem for a (p,2n) reaction to populate low spin states of 195Au. Both conversion electrons and gamma-rays were detected in coincidence between ICEBall and a single high-purity germanium detector. A total of 14 conversion coeffcients were measured. The results will be presented and compared to previous results. This work was supported by the National Science Foundation under contract number NSF PHY-1068192. M.P. Metlay, J.X. Saladin, I.Y. Lee, and O. Dietzsch, Nucl. Instrum. Meth. A, 336, 162 (1993).

  15. Identification of a Novel β-Globin Mutation (HBB: C.189_195delTCATGGC) in a Chinese Family.

    Science.gov (United States)

    He, Sheng; Lin, Li; Wei, Yuan; Chen, Biyan; Yi, Shang; Chen, Qiuli; Qiu, XiaoXia; Wei, Hongwei; Li, Guojian; Zheng, Chenguang

    2016-08-01

    β-Thalassemia (β-thal) is one of the most common genetic disorders worldwide. Molecular characterization of β-thal is essential for prevention and understanding the biology of the disease. More and more rare and novel mutations are being reported. Here, we report a novel 7 bp deletion at codons 63-65 (HBB: c.189_195delTCATGGC) in exon 2 of the β-globin gene in a family from Guangxi Province, China. This novel mutation causes a shift in the normal reading frame of the β-globin coding sequence and created a stop codon at codon 87 in exon 2, which leads to a β(0)-thal phenotype. PMID:27492766

  16. Low toxicity binder systems for tape cast Ce0.9Gd0.1O1.95 laminates

    DEFF Research Database (Denmark)

    Klemensø, Trine; Menon, Mohan; Ramousse, Severine

    2010-01-01

    Conventional binder systems for tape casting contain toxic phthalate plasticizers and butanone (MEK) as part of the solvent. The effects of exchanging the phthalate with a non-toxic alternative, and butanone with ethanol, were studied on laminates of high-green density CGO (Ce0.9Gd0.1O1.95) tapes....... Samples were prepared with a binder system containing DBP (dibutyl phthalate) plasticizer and MEK solvent, and with a binder system based on a non-toxic non-phthalate plasticizer and ethanol. In both systems, the weight ratio of plasticizer to the PVB (polyvinyl butyral) binder was varied between 0.......4 and 0.7. Substitution to the less toxic binder system had no adverse impacts on the microstructure. In fact, denser packing and improved homogeneity were observed with the non-phthalate-based system at ratio 0.5 indicating improved dispersion in this system. The denser packing also coincided...

  17. Impact of the first-forbidden β decay on the production of A ∼ 195 r-process peak

    Science.gov (United States)

    Nishimura, Nobuya; Podolyák, Zsolt; Fang, Dong-Liang; Suzuki, Toshio

    2016-05-01

    We investigated the effects of first-forbidden transitions in β decays on the production of the r-process A ∼ 195 peak. The theoretical calculated β-decay rates with β-delayed neutron emission were examined using several astrophysical conditions. As the FF decay is dominant in N ∼ 126 neutron-rich nuclei, their inclusion shortens β-decay lifetimes and shifts the abundance peak towards higher masses. Additionally, the inclusion of the β-delayed neutron emission results in a wider abundance peak, and smoothens the mass distribution by removing the odd-even mass staggering. The effects are commonly seen in the results of all adopted astrophysical models. Nevertheless there are quantitative differences, indicating that remaining uncertainty in the determination of half-lives for N = 126 nuclei is still significant in order to determine the production of the r-process peak.

  18. Impact of the first-forbidden $\\beta$ decay on the production of $A \\sim 195$ r-process peak

    CERN Document Server

    Nishimura, Nobuya; Fang, Dong-Liang; Suzuki, Toshio

    2016-01-01

    We investigated the effects of first-forbidden transitions in $\\beta$ decays on the production of the r-process $A \\sim 195$ peak. The theoretical calculated $\\beta$-decay rates with $\\beta$-delayed neutron emission were examined using several astrophysical conditions. As the first-borbidden decay is dominant in $N \\sim 126$ neutron-rich nuclei, their inclusion shortens $\\beta$-decay lifetimes and shifts the abundance peak towards higher masses. Additionally, the inclusion of the $\\beta$-delayed neutron emission results in a wider abundance peak, and smoothens the mass distribution by removing the odd-even mass staggering. The effects are commonly seen in the results of all adopted astrophysical models. Nevertheless there are quantitative differences, indicating that remaining uncertainty in the determination of half-lives for $N=126$ nuclei is still significant in order to determine the production of the r-process peak.

  19. Impact of the first-forbidden β decay on the production of A∼195 r-process peak

    Directory of Open Access Journals (Sweden)

    Nobuya Nishimura

    2016-05-01

    Full Text Available We investigated the effects of first-forbidden transitions in β decays on the production of the r-process A∼195 peak. The theoretical calculated β-decay rates with β-delayed neutron emission were examined using several astrophysical conditions. As the FF decay is dominant in N∼126 neutron-rich nuclei, their inclusion shortens β-decay lifetimes and shifts the abundance peak towards higher masses. Additionally, the inclusion of the β-delayed neutron emission results in a wider abundance peak, and smoothens the mass distribution by removing the odd–even mass staggering. The effects are commonly seen in the results of all adopted astrophysical models. Nevertheless there are quantitative differences, indicating that remaining uncertainty in the determination of half-lives for N=126 nuclei is still significant in order to determine the production of the r-process peak.

  20. Studies on proximity effect in Mo/Bi1.95Sb0.05Se3 hybrid structure

    Science.gov (United States)

    Amaladass, E. P.; Sharma, Shilpam; Devidas, T. R.; Mani, Awadhesh

    2016-06-01

    Proximity effect in a mechanically exfoliated Bi1.95Sb0.05Se3 topological insulator (TI) single crystal partially covered with disordered superconducting (SC) Mo thin film is reported. Magneto-transport measurement was performed simultaneously across three different regions of the sample viz. SC, TI and SC / TI junction. Resistance measured across SC shows a T C at 4.3 K concomitantly the resistance measurement on TI showed a metallic trend with a steep upturn at T C. Magneto-resistance (MR) measurement on TI exhibit a positive MR with Shubnikov-de Haas (SdH) oscillations, whereas on SC a positive MR superimposed with steep cusp close to T C is observed. Across SC/TI junction both SdH oscillation and the cusp were observed. The frequency of SdH oscillation on SC / TI junction is found to be lesser (~125 T) as compared to a reference Bi1.95Sb0.05Se3 sample (~174 T). Upper critical field HC2 deduced from WHH fit was found to be 17.14 T for a reference Mo film whereas Mo film deposited on TI showed a decreased H C2 of 4.05 T. The coherence length for the former was found to be 4.38 nm and for the latter 9.01 nm. The interaction between the spin-less Cooper pairs in SC with the spin-momentum locked carriers on the surface of TI is believed to cause such changes in transport properties.

  1. Effects on rat testis of 1.95-GHz W-CDMA for IMT-2000 cellular phones.

    Science.gov (United States)

    Imai, Norio; Kawabe, Mayumi; Hikage, Takashi; Nojima, Toshio; Takahashi, Satoru; Shirai, Tomoyuki

    2011-08-01

    In recent years concern has arisen whether carrying a cellular phone near the reproductive organs such as the testes may cause dysfunction and particularly decrease in sperm development and production, and thus fertility in men. The present study was performed to investigate the effects of a 1.95 GHz electromagnetic field on testicular function in male Sprague-Dawley rats. Five week old animals were divided into 3 groups of 24 each and a 1.95-GHz wide-band code division multiple access (W-CDMA) signal, which is used for the freedom of mobile multimedia access (FOMA), was employed for whole body exposure for 5 hours per day, 7 days a week for 5 weeks (the period from the age of 5 to 10 weeks, corresponding to reproductive maturation in the rat). Whole-body average specific absorption rates (SAR) for individuals were designed to be 0.4 and 0.08 W/kg respectively. The control group received sham exposure. There were no differences in body weight gain or weights of the testis, epididymis, seminal vesicles, and prostate among the groups. The number of sperm in the testis and epididymis were not decreased in the electromagnetic field (EMF) exposed groups, and, in fact, the testicular sperm count was significantly increased with the 0.4 SAR. Abnormalities of sperm motility or morphology and the histological appearance of seminiferous tubules, including the stage of the spermatogenic cycle, were not observed. Thus, under the present exposure conditions, no testicular toxicity was evident.

  2. STUDY OF THE EXPRESSION OF CD30 AND CD195 IN PATIENTS WITH GRAVES DISEASE WITH 131 I THERAPY AND THE CORRELATION BETWEEN THEIR EXPRESSION AND SHORT-TERM PROGNOSIS%CD30、CD195在Graves病病人131 I治疗前后的表达及短期预后相关性研究

    Institute of Scientific and Technical Information of China (English)

    席文琪; 皇甫建; 肖瑞; 李彩萍; 托娅; 王成; 王春梅

    2014-01-01

    Objective:To examine the expression of CD195 and CD30 of the T-helper lymphocyte ( Th) from peripheral blood before and after 131 I therapy,in order to explore the balance mechanism of Th1/Th2 in Graves' disease ( GD ) and the clinical significance. Methods:The expression level of CD195 and CD30 of from 40 GD patients and 40 healthy controls were examined by Flow Cytometry. The level of FT 3、FT 4 and TSH were also examined by chemiluminanscent. Results:( 1 ) The expression level of CD195 of GD patients without131 I therapy was lower than that of the healthy controls (P<0. 05). While CD30 level was higher than that of controls. The ratio of CD195 and CD30 was lower than that of controls(P<0. 01). (2)34 GD patients with131I treatment showed reducedhypothyroidism. The CD195 level of GD patients showing reduced hyperthyroidism was increased and the CD30 was de-creased ( P<0 . 05 );the ration of CD195/CD30 was increased and showed significant difference comparing to the healthy controls ( P<0 . 01 ) . Conclusions:( 1 ) The mechanism of GD has the correlation with the balance of Th1/Th2 . ( 2 ) The level of CD195 and CD30 and the variation of ratio between them may be involved in pathogenesis of GD, therefore it will be useful for studying the mechanism of GD and evaluation of the short-term prognosis of 131 I therapy.%目的:本实验拟通过测定GD病人131 I治疗前后外周血辅助性T淋巴细胞膜表面CD30、CD195的表达,探讨GD病人Th1/Th2平衡机制变化及其可能的临床意义。方法:选择40例GD病人和40例健康对照组为研究对象,应用流式细胞术检测GD病人131 I治疗前及治疗后6mo的外周血淋巴细胞膜表面CD195、CD30的变化以及临床症状和甲状腺功能。结果:(1)GD病人治疗前CD195显著低于健康对照组(P<0.05);CD30高于健康对照组,CD195/CD30低于健康对照组(P<0.01)。(2)GD病人131I治疗后6mo 34例甲亢缓解。治疗后缓解组CD195上升,CD30下降,与治疗

  3. Densification and Grain Growth during Early-stage Sintering of Ce0.9Gd0.1O1.95-δ in Reducing Atmosphere

    DEFF Research Database (Denmark)

    He, Zeming; Yuan, Hao; Glasscock, Julie;

    2010-01-01

    The present work investigates the processes of densification and grain growth of Ce0.9Gd0.1O1.95-δ (CGO10) during sintering in reducing atmosphere. Sintering variables were experimentally characterized and analyzed using defect chemistry and sintering constitutive laws. Based on the achieved...

  4. Powder electrochemical properties with different particle sizes of spinel LiAl0.05Mn1.95O4 synthesized by sol-gel method

    Institute of Scientific and Technical Information of China (English)

    YI Tingfeng; WANG Dianlong; GAO Kun; HU Xinguo

    2007-01-01

    An Al-doped spinel lithium manganese oxide was prepared by the adipic acid-assisted sol-gel method at 800℃, and the cathode materials (LiAl0.05Mn1.95O4) with different particle sizes were obtained through ball milling. The effects of particle size on the electrochemical performance of LiAl0.05Mn1.95O4 samples were investigated by differential thermal analysis and thermogravimetry, X-ray diffraction, galvanostatic charge-discharge test, cyclic voltammetry, and electrochemical impedance spectroscopy. The results indicate that all samples with different particle sizes show the same pure spinel phase and good crystal structure; LiAl0.05Mn1.95O4 with D50 = 17.3 μm shows better capacity retention; LiAl0.05Mn1.95O4 cathode materials with small particle size have a bigger resistance of charge transfer than the large one, and the particle size has significant effects on the electrochemical performance of Al-doped spinel LiMn2O4 cathode materials.

  5. Inhibition of fibrin polymerization by synthetic peptides corresponding to Aalpha195-205 and gamma69-77 sites of fibrin molecule

    NARCIS (Netherlands)

    Pozniak, T.A.; Urvant, L.P.; Gritsenko, P.; Chernishov, V.I.; Pydiura, N.A.; Lugovskoi, E.V.; Komisarenko, S.V.

    2014-01-01

    Using the idea of "proline brackets" we have found four sites in fibrin amino acid sequence, and appropriate peptides were synthesized: gamma69NPDESSKPN77, Bbeta228QPDSSVKPY236, Bbeta455RPFFPQ460 and Aalpha195LPSRDRQHLPL205. Turbidity and electron-microscopy analyses have demonstrated that synthetic

  6. Investigation of the use of an {alpha} + Xn reaction channel to enhance the population of superdeformed states in {sup 193}Hg and {sup 195}Hg

    Energy Technology Data Exchange (ETDEWEB)

    Zwartz, G.; Drake, T.E.; Cromaz, M. [Department of Physics, University of Toronto, Toronto, Ontario M5S-1A7 (Canada); Ward, D.; Janzen, V.; Galindo-Uribarri, A. [Chalk River Laboratories, Chalk River, Ontario K0J-1J0 (Canada); Prevost, D.; Waddington, J.; Mullins, S.M. [Department of Physics and Astronomy, McMaster University, Hamilton, Ontario L8S-4K1 (Canada)

    2000-11-01

    A study was made to determine whether the population of superdeformed states in {sup 193}Hg and {sup 195}Hg can be enhanced by using reactions in which alpha particles are emitted. The search utilized a {sup 184}W({sup 18}O,{alpha} Xn) reaction at 115 and 120 MeV for the {sup 193}Hg study and a {sup 186}W({sup 18}O,{alpha} Xn) reaction at 105 and 110 MeV for the {sup 195}Hg study. Two known superdeformed states of {sup 193}Hg were observed. The intensities of the superdeformed states in {sup 193}Hg populated by a reaction involving the emission of an alpha particle were found to be reduced by at least a factor of four relative to the intensities of these states produced in reactions involving only the emission of neutrons and {gamma}-rays. No rotational bands built on superdeformed states in {sup 195}Hg with transition intensities >0.8% of the total {sup 195}Hg yield were found. Evidence is shown that the energy of the alpha particle that is associated with superdeformed states may be lower than that of alpha particles associated with normally deformed states. (author)

  7. 儿童非霍奇金淋巴瘤195例临床病理分析%Clinical pathologic study of 195 cases of childhood non-Hodgkin s lymphoma

    Institute of Scientific and Technical Information of China (English)

    王佳; 奚政君; 李稻

    2011-01-01

    Objective To evaluate the clinical and pathological features of childhood non-Hodgkin's lymphoma (NHL). Methods A total of 195 NHL cases, with age younger than twelve years old, diagnosed from January 1982 to January 2010 in Xinhua Hospital were reviewed. Results The peak onset age is 6 - 8 years old. The male to female ratio is 2.3 : 1 and male patients predominate in each subtype. The cases in stage III and IV account for 49.2%. The most common subtypes were lymphoblastic lymphoma (LBL) , Burkitt lymphoma (BL) and anaplastic large cell lymphoma (ALCL). About 88.8% cases of LBL is T-cell lymphoma while all the BL is B-cell lymphoma and all the ALCL is T-cell lymphoma. More than 1/3 (37.9%) of all the cases have primary extranodal lymphoma. More than one organ involvement was found in 56.1% of LBL cases when they were diagnosed. Conclusions Childhood NHL differs greatly from adult NHL in clinical and pathological aspects. Immunohistochemistry plays an important role in diagnosis.%目的 探讨儿童非霍奇金淋巴瘤(NHL)的临床病理特点.方法 收集1982年1月-2010年1月诊断的非霍奇金淋巴瘤病例195例,进行临床和病理分析.结果 儿童NHL发病年龄高峰在6~8岁,男女之比为2.3:1,III期和IV期占49.2%.病理组织类型主要有淋巴母细胞性淋巴瘤(LBL)、Burkitt淋巴瘤(BL)、间变性大细胞性淋巴瘤(ALCL);88.8%LBL为T细胞性淋巴瘤,BL皆为B细胞性淋巴瘤,ALCL皆为T细胞性淋巴瘤.37.9%病例首发于淋巴结外组织,56.1%LBL患儿确诊时已累及1个以上部位.结论 儿童NHL的临床及病理表现与成人NHL存在很大差异.免疫组化等技术对NHL的病理诊断有重要作用.

  8. Design of 195/60R15 88H Passenger Car Radial Tire%195/60R1588H轿车子午线轮胎的设计

    Institute of Scientific and Technical Information of China (English)

    李世军; 邬素华

    2014-01-01

    介绍195/60R1588H轿车子午线轮胎的设计。结构设计:轮胎外直径614 mm,断面宽度212 mm,行驶面宽度160 mm,胎圈着合直径379 mm,胎圈着合宽度178 mm,断面水平轴位置(H1/H2)1.03,胎面采用4条纵向花纹主沟,花纹饱和度63.4%。施工设计:胎面采用三方四块结构,胎体采用1层1670dtex/2尺寸稳定型聚酯帘布,带束层采用2层2+2×0.25HT钢丝帘布和1层930dtex/2锦纶66帘布。采用二次法成型机成型,B型硫化机硫化。成品轮胎强度性能和脱圈阻力达到国家标准要求,耐久性能和高速性能达到企业标准要求。%The design of 195/60R15 88H passenger car radial tire is presented in this paper. In the structural design, the parameters are as follows: tire overall diameter 614 mm, cross sectional width 212 mm, width of running surface 160 mm, bead diameter at rim seat 379 mm, bead width at rim seat 178 mm, maximum width position of cross section﹙H1/H2) 1.03, 4 longitudinal main groove pattern, and pattern block ratio 63.4%. In the construction design, three formula and four piece tread is applied, one layer of 1670dtex/2 dimensionally stable polyester cord is used in carcass ply, and two layers of 2+2×0.25HT steel cord and one layer of 930dtex/2 nylon 66 cord are applied in the belt layer. The tire is built by using two stage tire building machine and cured on B-type vulcanizing machine. The experimental test results on the ifnished tire show that the strength performance of the tire and the bead unseating resistance meet the requirements of national standards, and the durability and high-speed performance meet the requirements of enterprise standards.

  9. Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    Liu Y

    2016-08-01

    Full Text Available Ying Liu,1,* Xin Wu,1,* Yuan Gao,2,* Jigang Zhang,1 Dandan Zhang,1 Shengying Gu,1 Guanhua Zhu,1 Gaolin Liu,1 Xiaoyu Li1 1Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 2Department of Pharmaceutics, Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Liver cancer is the fifth most commonly diagnosed malignancy, of which hepatocellular carcinoma (HCC represents the dominating histological subtype. Antiangiogenic therapy aimed at vascular endothelial growth factor (VEGF has shown promising but deficient clinical prospects on account of vasculogenic mimicry, a highly patterned vascular channel distinguished from the endothelium-dependent blood vessel, which may function as blood supply networks occurring in aggressive tumors including HCC. In this study, we used a new cationic peptide, disulfide cross-linked stearylated polyarginine peptide modified with histidine (H3R5, as a reducible vector, cell penetrating peptide-modified aptamer (ST21 with specific binding to HCC cells to conjugate to peptide H3R5 as the targeting probe, miRNA-195 (miR195as a powerful gene drug to inhibit VEGF, and fasudil to suppress vasculogenic mimicry by blocking ROCK2, all of which were simultaneously encapsulated in the same nanoparticles. Fasudil was loaded by ammonium sulfate-induced transmembrane electrochemical gradient and miR195 was condensed through electrostatic interaction. ST21-H3R5-polyethylene glycol (PEG exhibited excellent loading capacities for both fasudil and miR195 with adjustable dosing ratios. Western blot analysis showed that FasudilST21-H3R5-PEGmiR195 had strong silencing activity of ROCK2 and VEGF, as compared with FasudilH3R5-PEGmiR195. In vitro and in vivo experiments confirmed that ST21-modified nanoparticles showed significantly higher cellular uptake and therapeutic efficacy in tumor

  10. Value of combined detection of serum miR-21,miR-195 and miR-222 in the diagnosis of early breast cancer

    Institute of Scientific and Technical Information of China (English)

    Wen-Zhao Zhang; Ying Li; De-Xiang Wu

    2016-01-01

    Objective:To study level of miRNA in the serum of early breast carcinoma patients and to evaluate the clinical diagnostic value of combined detection of early breast carcinoma. Methods:A total of 54 cases of early breast carcinoma, 58 cases of benign breast diseases and 70 cases of healthy physical examination women were selected as the research subjects, to analysis serum miR-21, miR-195 and miR-222 levels by fluorescence quantitative PCR method and to analyze the diagnostic value of single and combined detection in early breast cancer by receiver operating characteristic curve. Results:The relative expression levels of miR-21, miR-222 and miR-195 in early breast carcinoma patients were significantly higher than those in benign breast disease and healthy controls;there was no significant difference in the relative expression of miR-21, miR-222 and miR-195 in the benign breast disease group and healthy control group;receiver operating characteristic curve analysis showed that AUC of miR-21, miR-195 and miR-222 in the diagnosis of early breast carcinoma were 0.805, 0.86 and 0.848 respectively, the sensitivity were 63.3%, 70.0%and 70.0%, and the specificity were 86.7%, 93.3%and 90.0%;AUC, sensitivity and specificity of the combined detection were 0.974, 93.3%and 96.7%respectively. Conclusion:miR-21, miR-195 and miR-222 levels in serum of patients with early breast carcinoma rise, the combined detection of the 3 indicators have a high diagnostic value for early breast carcinoma, and contribute to early breast carcinoma screening and diagnosis.

  11. CXC195 suppresses proliferation and inflammatory response in LPS-induced human hepatocellular carcinoma cells via regulating TLR4-MyD88-TAK1-mediated NF-κB and MAPK pathway

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yiting [Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang (China); Tu, Qunfei [Department of Thyroid Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang (China); Yan, Wei; Xiao, Dan; Zeng, Zhimin; Ouyang, Yuming; Huang, Long; Cai, Jing; Zeng, Xiaoli; Chen, Ya-Jie [Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang (China); Liu, Anwen, E-mail: liuanweinanchang@163.com [Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang (China)

    2015-01-02

    Highlights: • CXC195 exhibited significant anti-proliferative effect and induced cell cycle arrest in LPS-induced HepG2 cells. • CXC195 suppressed the release of pro-inflammatory mediators in LPS-induced HepG2 cells. • CXC195 regulated TLR4-MyD88-TAK1-mediated NF-κB and MAPK pathway in LPS-induced HepG2 cells. - Abstract: CXC195 showed strong protective effects in neuronal apoptosis by exerting its antioxidant activity. However, the anti-cancer effects of CXC195 is still with limited acquaintance. Here, we investigated the role of CXC195 in lipopolysaccharide (LPS)-induced human hepatocellular carcinoma (HCC) cells lines (HepG2) and the possible signaling pathways. CXC195 exhibited significant anti-proliferative effect and induced cell cycle arrest in LPS-induced HepG2 cells. In addition, CXC195 suppressed the release of pro-inflammatory mediators in LPS-induced HepG2 cells, including TNF-α, iNOS, IL-1β, IL-6, CC chemokine ligand (CCL)-2, CCL-22 and epidermal growth factor receptor (EGFR). Moreover, CXC195 inhibited the expressions and interactions of TLR4, MyD88 and TAK1, NF-κB translocation to nucleus and its DNA binding activity, phosphorylation of ERK1/2, p38 and JNK. Our results suggested that treatment with CXC195 could attenuate the TLR4-mediated proliferation and inflammatory response in LPS-induced HepG2 cells, thus might be beneficial for the treatment of HCC.

  12. Trimeric structure of (+)-pinoresinol-forming dirigent protein at 1.95 Å resolution with three isolated active sites.

    Science.gov (United States)

    Kim, Kye-Won; Smith, Clyde A; Daily, Michael D; Cort, John R; Davin, Laurence B; Lewis, Norman G

    2015-01-16

    Control over phenoxy radical-radical coupling reactions in vivo in vascular plants was enigmatic until our discovery of dirigent proteins (DPs, from the Latin dirigere, to guide or align). The first three-dimensional structure of a DP ((+)-pinoresinol-forming DP, 1.95 Å resolution, rhombohedral space group H32)) is reported herein. It has a tightly packed trimeric structure with an eight-stranded β-barrel topology for each DP monomer. Each putative substrate binding and orientation coupling site is located on the trimer surface but too far apart for intermolecular coupling between sites. It is proposed that each site enables stereoselective coupling (using either two coniferyl alcohol radicals or a radical and a monolignol). Interestingly, there are six differentially conserved residues in DPs affording either the (+)- or (-)-antipodes in the vicinity of the putative binding site and region known to control stereoselectivity. DPs are involved in lignan biosynthesis, whereas dirigent domains/sites have been implicated in lignin deposition.

  13. Trimeric Structure of (+)-Pinoresinol-forming Dirigent Protein at 1.95 Å Resolution with Three Isolated Active Sites*

    Science.gov (United States)

    Kim, Kye-Won; Smith, Clyde A.; Daily, Michael D.; Cort, John R.; Davin, Laurence B.; Lewis, Norman G.

    2015-01-01

    Control over phenoxy radical-radical coupling reactions in vivo in vascular plants was enigmatic until our discovery of dirigent proteins (DPs, from the Latin dirigere, to guide or align). The first three-dimensional structure of a DP ((+)-pinoresinol-forming DP, 1.95 Å resolution, rhombohedral space group H32)) is reported herein. It has a tightly packed trimeric structure with an eight-stranded β-barrel topology for each DP monomer. Each putative substrate binding and orientation coupling site is located on the trimer surface but too far apart for intermolecular coupling between sites. It is proposed that each site enables stereoselective coupling (using either two coniferyl alcohol radicals or a radical and a monolignol). Interestingly, there are six differentially conserved residues in DPs affording either the (+)- or (−)-antipodes in the vicinity of the putative binding site and region known to control stereoselectivity. DPs are involved in lignan biosynthesis, whereas dirigent domains/sites have been implicated in lignin deposition. PMID:25411250

  14. Early hominin diet included diverse terrestrial and aquatic animals 1.95 Ma in East Turkana, Kenya.

    Science.gov (United States)

    Braun, David R; Harris, John W K; Levin, Naomi E; McCoy, Jack T; Herries, Andy I R; Bamford, Marion K; Bishop, Laura C; Richmond, Brian G; Kibunjia, Mzalendo

    2010-06-01

    The manufacture of stone tools and their use to access animal tissues by Pliocene hominins marks the origin of a key adaptation in human evolutionary history. Here we report an in situ archaeological assemblage from the Koobi Fora Formation in northern Kenya that provides a unique combination of faunal remains, some with direct evidence of butchery, and Oldowan artifacts, which are well dated to 1.95 Ma. This site provides the oldest in situ evidence that hominins, predating Homo erectus, enjoyed access to carcasses of terrestrial and aquatic animals that they butchered in a well-watered habitat. It also provides the earliest definitive evidence of the incorporation into the hominin diet of various aquatic animals including turtles, crocodiles, and fish, which are rich sources of specific nutrients needed in human brain growth. The evidence here shows that these critical brain-growth compounds were part of the diets of hominins before the appearance of Homo ergaster/erectus and could have played an important role in the evolution of larger brains in the early history of our lineage. PMID:20534571

  15. Development of a diagnostic schedule for a defective LC-195V5 CNC milling machine using PERT

    Directory of Open Access Journals (Sweden)

    Oluwole Olayinka AGBOOLA

    2016-07-01

    Full Text Available Computer Numerical Control CNC machine tools usage are more and more extensive, its fault diagnosis research is becoming more essential. Failure forms accorded these machines are diversified, and fault reasons are very complicated. It should not be left unattended to, because this could lead to further deterioration. One of the parameters used in determining the efficiency of a technician (who repairs machine tools is the time saved in locating faults, hence the development of a diagnostic schedule which shows the sequential means of troubleshooting within a possible shortest time. In this research two approaches were used to diagnose a defective LC-195V5 CNC milling machine. Forward Pass (FP, which involves the diagnosis from electrical parts through Computer (CNC to mechanical component and Backward Pass (BP which involves the diagnosis from computer component through electrical parts to mechanical parts. Three different trials were conducted for each of the mode of diagnosis and the time to diagnose each component part was recorded. Based on the interrelationship of the component parts, two separate PERT (Project Evaluation & Review Techniques network diagrams were drawn and their Critical Paths were determined. The study reveals that Foward Pass method was able to save more time.

  16. Environmental sampling accounting at the Savannah River Plant. [IBM 360/195 computer-based accounting system

    Energy Technology Data Exchange (ETDEWEB)

    Zeigler, C.C.; Wood, M.B.

    1978-06-01

    At the Savannah River Plant Environmental Monitoring Laboratories, a computer-based systematic accounting method was developed to ensure that all scheduled samples are collected, processed through the laboratory, and counted without delay. The system employs an IBM 360/195 computer with a magnetic tape master file, an on-line disk file, and cathode ray tube (CRT) terminals. Scheduling and accounting are accomplished by using computer-generated schedules, collection labels, and output/input cards. For each scheduled sample and analysis, a printed card is issued for collection, laboratory analysis, and counting. The cards also contain information needed by personnel performing the jobs, such as sample location, aliquot to be processed, or procedure number. Manual entries are made on the cards when each step in the process is completed. Additional pertinent data are also manually entered on the cards; e.g., entries are made explaining why a sample is not collected, the sample aliquot in the event a nonstandard aliquot is processed, field measurement results, and analytical results. These manually entered data are keypunched and read into the computer files. The computer files are audited daily, and summaries of samples not processed in pre-established normal time intervals are issued. The progress of sample analyses can also be readily determined at any time using the CRT terminal. Historic data are also maintained on magnetic tape and workload summaries are issued showing the number of samples and number of determinations per month.

  17. Dyeing properties of Reactive Red 195 on ramie yarn in liquid ammonia%活性红195对苎麻纱线的液氨染色性能研究

    Institute of Scientific and Technical Information of China (English)

    黄迎亚; 刘帆; 何林蔚; 彭雄义; 蔡映杰; 曾庆福

    2015-01-01

    采用环氧丙基三甲基氯化铵对苎麻纱线进行阳离子改性.对未改性和阳离子改性的苎麻纱线,使用活性红195在液氨中于-35℃,浴比1:35,染色时间10~600 s,染料用量1%~100%(omf)进行染色;染后在100℃下焙烘10 min.结果表明阳离子改性可提高染料竭染率、固色效率和耐水洗色牢度,但稍微降低耐摩擦色牢度.未改性和改性苎麻纱线在液氨染色中,染料的竭染率随染色时间的延长而增加,分别在60 s和180 s时达到染色平衡,其对应的竭染率分别为21%和34%;未改性苎麻纱线的固色效率在40%~76%,而改性苎麻纱线则高达100%.未改性和改性苎麻纱线在液氨染色中的染料竭染率随染料用量的增加而下降;未改性苎麻纱线的固色效率在25%~34%,而改性苎麻纱线则从染料用量50%(omf)时的100%下降到染料用量100%(omf)时的85%.但是,2种纱线的单位质量染料吸附量都随着染料用量的增加呈直线上升的趋势.%Cationic modified ramie yarn was prepared with 2,3- epoxypropytrimethylammonium chloride agent. Subsequently, the control and cationic modified ramie yarns were dyed in liquid ammonia with Reactive Red 195 at a liquor ratio of 1:35 with 1%~100%(omf) of dye concentration at- 35 ℃ for 10 s to 600 s. After dyeing, the samples were cured at 100 ℃ for 10 min. The results showed that the cationic modification in-creased the dye exhaustion and fixation, and improved the washing fastness, but decreased the rubbing fast-ness. The exhaustion percentages of both control and cationic modified ramie yarn were increased with the in-creasing of dyeing time, and the equilibrium was reached at 60 s and 180 s with 21% and 34% of exhaustion percentage, respectively. The fixation values of control ramie were between 40%~76%, while the cationic ones were approaching to 100%. The exhaustion percentage of both samples decreased with the increase of dye concentration. The fixation efficiency of control ramie

  18. 16PF test for 195 patients of pectus excavatum%195例漏斗胸患者16种人格因素问卷测试结果分析

    Institute of Scientific and Technical Information of China (English)

    赵京; 肖利军; 骆利; 邵虹

    2014-01-01

    目的了解漏斗胸患者的人格特征,为建立该病的生理-心理-社会综合治疗方案提供依据。方法选取2009年10月至2012年2月期间入住本院胸外科诊治且心理问卷有效的漏斗胸患者195例,使用心理测试软件系统中的卡特尔16种人格因素问卷(16PF)对其进行测试,并与中国常模进行对比分析。结果男性患者卡特尔16种人格因素问卷的兴奋性、幻想性、恃强性、有恒性、怀疑性、独立性6项因子平均粗分与中国常模比较有显著性差异(P<0.05或<0.01)。女性患者在乐群性、兴奋性、幻想性、有恒性、怀疑性、独立性6项因子平均粗分与中国常模比较有显著性差异(P<0.05或<0.01)。结论漏斗胸患者人格特征与常模比较存在一定差异,术前进行心理测试可为制订该病的合理治疗方案提供重要参考依据。%Objective To investigate the mental health status and personality character of patients with pectus excavatum, to supply important basis of comprehensive treatment scheme of Biopsychosocial. Methods The data extracted from 195 voluntary patients by sixteen personality factor questionnaire (16PF) effectively in department of thoracic surgery of our hospital between 2009 to 2011, and it was compared with Chinese norm for adults. Results There were signiifcant differences in average raw score of dominance, abstractedness, vigilance, rule-consciousness, liveliness, openness to change between male patients and Chinese norm (P<0.05 or P<0.01), and in warmth, abstractedness, vigilance, rule-Consciousness, liveliness, openness to change between female ones and norm (P<0.05 or P<0.01). Conclusion The level of psychosomatic health of patients with pectus excavatum is worse than those of healthy people, and their personality character is obvious. So it is important for the patients making psychological test before and after the operation to develop a reasonable treatment.

  19. Magnetocaloric properties of the Gd_5Si_(2.05-x)Ge_(1.95-x)Mn_(2x) compounds

    Institute of Scientific and Technical Information of China (English)

    E.Yüzüak; I.Dincer; Y.Elerman

    2010-01-01

    The influence of the manganese-alloying on the structure and magnetocaloric properties of the Gd5Si2.05Ge1.95 compound was studied by X-ray powder diffraction and magnetization measurements.The Gd5Si2.05-xGe1.95-xMn2x(2x=0,0.03 and 0.08) compounds crystallized in the Gd5Si2Ge2-type monoclinic structure.In all X-ray powder diffraction patterns,a minor hexagonal Gd5Si3 phase was observed as a second phase.With increasing Mn content,the unit cell volume increased.For the compounds with x=0,0.03 and 0.08,the fi...

  20. Synthesis of 195mPt radiolabelled cis-diamminedichloroplatinum(II) of high chemical and radiochemical purity using high performance liquid chromatography

    International Nuclear Information System (INIS)

    An improved method is described for the synthesis of 195mPt-radiolabelled cis-diamminedichloroplatinum(II). An amount of 10 mg of 95% enriched 194Pt was irradiated for 75 h in the hydraulic conveyer of the Kyoto University Reactor at a thermal neutron flux of approximately 8.15x1013 n.cm-2.sec-1 and the 195mPt-radiolabelled CDDP was purified using HPLC. The chemical yield is 61%, chemical purity is greater than 99.74%, the radiochemical purity is nearly 100%, and the specific activity is 7.4x106 Bq mg-1 CDDP (200 μCi mg-1 CDDP). (author) 9 refs.; 5 figs.; 1 tab

  1. Relationship between crystal growth mode, preferred orientation and magnetostriction of (Tb0.3Dy0.7)Fe1.95 alloys

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shirong; LI Kuoshe; YU Dunbo; LI Yongsheng; YANG Hongchuan; LI Hongwei; TU Ganfeng

    2008-01-01

    The relationship between crystal growth mode, preferred orientation and magnetostrictive properties of (Tb0.3Dy0.7)Fe1.95 alloys was investigated at different directional solidification rates. The results showed that preferred orientation had a strong influence on the characteristics of (Tb0.3Dy0.7)Fe1.95 alloys. At lower solidification rates, the sample with preferred orientation showed larger low-field magnetostriction and apparent compressive stress effect. The excessive solidification rate resulted in failure of preferred orientation and a poor magnetostrictive performance. With an increase in solidification rates, the crystal growth modes changed gradually from cellular and primary dendrite morphology to developed dendritic morphology. In addition, domain configurations were observed using magnetic force microscopy, and the change of magnetostrictive properties was interpreted in terms of revealing the domain configurations.

  2. M1 transitions between superdeformed states in {sup 194,195}Tl: The fingerprint of the i{sub 13/2} proton intruder orbital

    Energy Technology Data Exchange (ETDEWEB)

    Azaiez, F.; Duprat, J.; Sharpey-Schafer, J.F.; Aiche, M.; Bastin, G.; Beausang, C.W.; Bourgeois, C.; Clark, R.M.; Deloncle, I.; Duffait, R.; Gale, S.J.; Gall, B.; Hannachi, F.; Hibbert, I.; Joyce, M.J.; Kaci, A.; Kelly, W.H.; Korichi, A.; Le Coz, Y.; Meyer, M.; Perrin, N.; Poffe, N.; Porquet, M.G.; Redon, N.; Sergolle, H.; Schuck, C.; Simpson, J.; Wadsworth, R. [Inst. de Physique Nucleaire, 91 Orsay (France)]|[Oliver Lodge Lab., Univ. of Liverpool (United Kingdom)]|[C.S.N.S.M., IN2P3-CNRS, 91 Orsay (France)]|[Nuclear Structure Facility, Daresbury Lab., Daresbury, Warrington (United Kingdom)]|[Inst. de Physique Nucleaire de Lyon, IN2P3-CNRS, Univ. Claude Bernard, 69 Villeurbanne (France)]|[Dept. of Physics, Univ. of York (United Kingdom)]|[Iowa State Univ., Ames, IA (United States)]|[Univ. of Oxford, Dept. of Physics (United Kingdom)

    1995-12-31

    Recent data from the EUROGAM array have revealed dipole transitions linking signature partner superdeformed bands in {sup 194}Tl and {sup 195}Tl nuclei. Measurements of the decay branching ratios, taken together with the average quadrupole moment of the neighboring superdeformed nuclei, enable the absolute M1 strengths to be determined. From these data and using the strong coupling model, we find that two SD bands in {sup 195}Tl are due to the 81st proton being in the [642]5/2{sup +} orbital and four from the six SD bands in {sup 194}Tl correspond to a configuration where the intrinsic spins of the single proton and single neutron are aligned. (orig.).

  3. Synthesis of 195mPt radiolabeled (-)-(R)-2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)-2-platinum(II) monohydrate using high performance liquid chromatography

    International Nuclear Information System (INIS)

    An experimental method is described for the synthesis of 195mPt-radiolabeled (-)-(R)-2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)-2-platinum (II) (DWA2114R). An amount of 10 mg of 95% enriched 194Pt was irradiated for 75 h in the hydraulic conveyer of the KUR at a thermal neutron flux of approximately 8.1x1013 n.cm-2.sec-1 and the 195mPt-radiolabeled DWA2114R was purified using HPLC. The chemical yield is higher than 65%, its chemical purity is greater than 99.2%, the radiochemical purity is nearly 100%, and the specific activity is 6.7 MBq. mg-1 DWA2114R. (author) 12 refs.; 4 figs.; 1 tab

  4. Site-directed mutagenesis from Arg195 to His of a microalgal chloroplastidial glycerol-3-phosphate acyltransferase causes an increase in phospholipid levels in yeast

    Directory of Open Access Journals (Sweden)

    Long-Ling eOuyang

    2016-03-01

    Full Text Available To analyze the contribution of glycerol-3-phosphate acyltransferase (GPAT to the first acylation of glycerol-3-phosphate (G-3-P, the present study focused on a functional analysis of the GPAT gene from Lobosphaera incisa (designated as LiGPAT and the subcellular localization of the encoded protein LiGPAT. A full-length cDNA of LiGPAT consisting of a 1,305-bp ORF, a 1,652-bp 5′-UTR, and a 354-bp 3′-UTR, was cloned. The ORF encoded a 434-amino acid peptide, of which 63 residues at the N-terminus defined a chloroplast transit peptide. LiGPAT was exclusively localized to chloroplasts, which was shown by co-expression of LiGPAT with eGFP in Chlamydomonas reinhardtii and by immunogold labeling in L. incisa. Considering the conservation of His among the G-3-P binding sites from chloroplastidial GPATs and the substitution of His by Arg at position 195 in the LiGPAT mature protein (designated mLiGPAT, we established the heterologous expression of either mLiGPAT or its mutant (Arg195His (sdmLiGPAT in the GPAT-deficient yeast mutant gat1Δ. Lipid profile analyses of these transgenic yeasts not only validated the acylation function of LiGPAT but also indicated that the site-directed mutagenesis from Arg195 to His led to an increase in the phospholipid level in yeast. Semi-quantitative analysis of mLiGPAT and sdmLiGPAT, together with the structural superimposition of their G-3-P binding sites, indicated that the increased enzymatic activity was caused by the enlarged accessible surface of the phosphate group binding pocket when Arg195 was mutated to His. Thus, the potential of genetic manipulation of GPAT to increase the glycerolipid level in L. incisa and other microalgae would be of great interest.

  5. The use of tumour markers CEA, CA-195 and CA-242 in evaluating the response to chemotherapy in patients with advanced colorectal cancer.

    OpenAIRE

    Ward, U.; Primrose, J N; Finan, P. J.; Perren, T. J.; Selby, P.; Purves, D. A.; Cooper, E H

    1993-01-01

    Tumour markers CEA, CA-195 and CA-242 were measured in 33 patients undergoing chemotherapy for advanced colorectal cancer. The aim was to determine whether they could be used to accurately monitor the course of the disease, and reduce the need for imaging. Treatment with a 5-fluorouracil based regimen resulted in a partial response in nine patients (27%), whereas the remainder either had disease stabilisation or suffered from progression. Before treatment the CEA was elevated in 85% of patien...

  6. Effect of Addition of Al on Crystal Structure Microtexture and Magnetostriction Coefficient in Tb0.3 Dy0.7 Fe1.95 Alloy

    Institute of Scientific and Technical Information of China (English)

    Jiang Liping; Zhao Zengqi; Wu Shuangxia; Huang Jimin; Zuo Liang

    2004-01-01

    The effect of addition of A1 on crystal structure microtexture and magnetostrictioncoefficient in Tb0.3Dy0.7Fe1.95 alloy were studied.The results show that addition of A1 does not change crystal structure of alloy and the precipitates increase in the microtexture as addition of A1 increases.At a certain magnetic field, magnetostriction coefficient decreased as addition of Al increased.

  7. The quadrupole moments of 195-197Ausup(m)(11/2) and the low temperature thermal relaxation of gold in cadmium

    International Nuclear Information System (INIS)

    sup(195, 197m)Hg has been oriented at low temperature in a cadmium single crystal. From the orientation pattern of the 388 keV gamma ray Vsub(zz)(HgCd) = +1.82(25)x1018 V/cm2 has been deduced. Using the dipole-relaxation mechanism on the gold isomeric state, the relaxation constant Csub(K) = 0.044(5)Ks, the quadrupole interaction frequencies γsub(Q)(195m-AuCd) = +395(18) MHz, γsub(Q)(197m-AuCd) = +380(58) MHz and delta(E2/M1 ; 261 keV) < 0 are obtained from the orientation pattern of the 261 and 279 keV gamma rays. Using literature electric field gradient of gold in cadmium, Q(195m-Au,11/2) = (+)1.41(10) b and Q(197m-Au,11/2) = (+)1.35(22) b can be deduced. (Auth.)

  8. Oxygen permeation in thin, dense Ce0.9Gd0.1O 1.95- membranes I. Model study

    DEFF Research Database (Denmark)

    Chatzichristodoulou, Christodoulos; Søgaard, Martin; Hendriksen, Peter Vang

    2011-01-01

    A model of a supported planar Ce0.9Gd0.1O 1.95-δ oxygen membrane in a plug-flow setup was constructed and a sensitivity analysis of its performance under varying operating conditions and membrane parameters was performed. The model takes into account the driving force losses at the catalysts at t...... was analyzed by a separation of the various losses. The chemical expansion of Ce 0.9Gd0.1O1.95-δ under operation was estimated from the calculated oxygen activity and nonstoichiometry profiles inside the membrane. © 2011 The Electrochemical Society.......A model of a supported planar Ce0.9Gd0.1O 1.95-δ oxygen membrane in a plug-flow setup was constructed and a sensitivity analysis of its performance under varying operating conditions and membrane parameters was performed. The model takes into account the driving force losses at the catalysts...... at the feed and permeate side of the membrane, related to the gaseous oxygen reduction and fuel oxidation, respectively, as well as the gas conversion and gas diffusion resistances in the porous support structure at the permeate side. The temperature and oxygen activity dependence of the oxide ionic...

  9. Influence of conductive electroactive polymer polyaniline on electrochemical performance of LiMn1.95Al0.05O4 cathode for lithium ion batteries

    Indian Academy of Sciences (India)

    Chang-Ling Fan; Hari Om; Ke-He Zhang; Shao-Chang Han

    2013-11-01

    Conductive electroactive polymer polyaniline is utilized to substitute conductive additive acetylene black in the LiMn1.95Al0.05O4 cathode for lithium ion batteries. Results show that LiMn1.95Al0.05O4 possesses stable structure and good performance. Percolation theory is used to optimize the content of conductive additive in cathode. It shows that the conductivity of cathode reaches its maximum value when the content of conductive additives is 15 wt%. This is in agreement with the results of charge and discharge experiments. The application of polyaniline can evidently enhance the electrochemical performance of cathode. The discharge capacity of cathode using 15 wt% polyaniline is 95.9 mAh g-1 at the current density of 170 mA g-1. The charge transfer resistance under different depths of discharge of cathode is much lower compared with the use of acetylene black. It can be concluded that the application of polyaniline in cathode can greatly improve the electrochemical performances of LiMn1.95Al0.05O4 cathode.

  10. Chemonuclear studies for identification for new production routes for the therapeutically useful radionuclides {sup 140}Nd, {sup 192}Ir, {sup 191}Pt, {sup 193m}Pt, und {sup 195m}Pt; Kernchemische Studien zur Entwicklung neuerer Produktionsverfahren fuer die therapierelevanten Radionuklide {sup 140}Nd, {sup 192}Ir, {sup 191}Pt, {sup 193m}Pt, und {sup 195m}Pt

    Energy Technology Data Exchange (ETDEWEB)

    Hilgers, K.

    2005-12-15

    New production routes for the therapeutically useful radionuclides {sup 140}Nd, {sup 192}Ir, {sup 191}Pt, {sup 193m}Pt and {sup 195m}Pt were investigated. Cross section data were measured using the stacked-foil technique and compared with theoretical calculations. A production method for the platinum nuclides was developed. The {sup 141}Pr(p, 2n){sup 140}Nd and {sup nat}Ce({sup 3}He, xn){sup 140}Nd reactions were investigated for production of {sup 140}Nd. Cross section data of nuclear reactions leading to the side products {sup 141}Nd, {sup 139}Nd and {sup 139}Ce could also be achieved. The experimental data were compared with theoretical calculations using the code ALICE-IPPE. A comparison of the calculated thick target yields showed that the {sup 141}Pr(p, 2n){sup 140}Nd reaction gives a higher yield. The {sup 192}Os(p, n){sup 192}Ir reaction was examined in the context of the production of {sup 192}Ir. Cross section data were determined and compared with theoretical calculations using the codes ALICE-IPPE and EMPIRE II. The yield of this reaction was compared with the yield of the reactor production of this nuclide. The reactor production seems to be more suitable because of a higher purity and yield. Cross section data were measured for the {sup 192}Os({alpha}, n){sup 195m}Pt, {sup 192}Os({alpha}, 3n){sup 193m}Pt and {sup 192}Os({sup 3}He, 4n){sup 191}Pt reactions. The activity of {sup 193m}Pt and {sup 195m}Pt was determined by X-ray spectroscopy after a chemical separation procedure. The ALICE-IPPE code was found to be inappropriate to reproduce the experimental values. The calculated yields were compared with the yields of other reactions, especially the reactor production of {sup 195m}Pt. The yield of the {sup 192}Os({alpha}, n){sup 195m}Pt reaction is lower compared to the yield of the reactor production, but offers lower target costs and higher specific activity. A production method for {sup 193m}Pt and {sup 195m}Pt was developed. Batch yields of 0.9 MBq

  11. 195首治疗乳腺增生中药专利复方的用药规律分析%Study on Medication Patterns of Chinese Patent Medicine among 195 Breast Hyperplasia Cases

    Institute of Scientific and Technical Information of China (English)

    施学丽; 邓家刚; 蒋筱; 范丽丽; 赵晓芳; 郭超峰

    2013-01-01

    目的:应用数据挖掘技术中关联规则、聚类等方法分析乳腺增生中药专利复方配伍规律。方法:检索治疗乳腺增生中药专利复方,排除外用中药及中西药物合用的复方。对入选的中药专利复方进行术语规范化等处理,抽取信息、建立EXCEL表,应用数据分析软件包R2.15.2对数据进行关联规则分析,网络分析软件Cytoscape2.8.3聚类分析组方配伍规律。结果:195首治疗乳腺增生的中药专利复方中,发现配伍频数较高的中药为柴胡、香附、当归、夏枯草、白芍、栝蒌等;而出现频数极低且不常用的中药为八角枫叶、白鹤草等;常用的药对为柴胡-当归、莪术-三棱、乳香-没药等;强关联规则提示以柴胡、当归等核心药物组成的逍遥散为治疗乳腺增生的基本方;聚类分析结果发现连翘-土茯苓-三桠苦-功劳木-鸡血藤等“中药社团”。结论:通过对药物频数、药对、强关联规则、药物聚类的分析,可以揭示乳腺增生组方的配伍规律,为临床优化处方、提高疗效提供参考依据。%This study was aimed to reveal the medication patterns of Chinese patent medicine in the treatment of breast hyperplasia based on association rules and clustering of data mining technology. Articles on Chinese patent medicine in the treatment of breast hyperplasia were retrieved from databases. External formulas or those mixed with western drugs were excluded. Terminologies in the selected formulas were standardized. Information was extracted to build excelltables. Association rules analysis and cluster analysis were used to reveal the medication patterns of Chi-nese patent medicine in the treatment of breast hyperplasia with software R2.15.2 and Cytoscape 2.8.3. The results showed that Chinese medicinals with higher frequency in 195 formulas were Radix bupleuri, Rhizoma cyperi, Chinese Angelica, Selfheal, White Peony Root, Trichosanthes

  12. Mutation of Gly195 of the ChlH Subunit of Mg-chelatase Reduces Chlorophyll and Further Disrupts PS II Assembly in a Ycf48-Deficient Strain of Synechocystis sp. PCC 6803

    Science.gov (United States)

    Crawford, Tim S.; Eaton-Rye, Julian J.; Summerfield, Tina C.

    2016-01-01

    Biogenesis of the photosystems in oxygenic phototrophs requires co-translational insertion of chlorophyll a. The first committed step of chlorophyll a biosynthesis is the insertion of a Mg2+ ion into the tetrapyrrole intermediate protoporphyrin IX, catalyzed by Mg-chelatase. We have identified a Synechocystis sp. PCC 6803 strain with a spontaneous mutation in chlH that results in a Gly195 to Glu substitution in a conserved region of the catalytic subunit of Mg-chelatase. Mutant strains containing the ChlH Gly195 to Glu mutation were generated using a two-step protocol that introduced the chlH gene into a putative neutral site in the chromosome prior to deletion of the native gene. The Gly195 to Glu mutation resulted in strains with decreased chlorophyll a. Deletion of the PS II assembly factor Ycf48 in a strain carrying the ChlH Gly195 to Glu mutation did not grow photoautotrophically. In addition, the ChlH-G195E:ΔYcf48 strain showed impaired PS II activity and decreased assembly of PS II centers in comparison to a ΔYcf48 strain. We suggest decreased chlorophyll in the ChlH-G195E mutant provides a background to screen for the role of assembly factors that are not essential under optimal growth conditions. PMID:27489555

  13. 燃烧辅助合成LiNi0.05Mn1.95O4粉体及其性质研究%Combustion-assisted Synthesis and Characterization of LiNi0.05Mn1.95O4 Powders

    Institute of Scientific and Technical Information of China (English)

    吴显明; 陈上; 刘金练; 麦发任; 李长安

    2012-01-01

    以醋酸锂、醋酸锰、硝酸镍、柠檬酸、乙二醇为原料,采用燃烧辅助合成锂离子电池正极材料LiNi0.05Mn1.95O4.采用X射线衍射、扫描电子显微镜、循环伏安、恒电流充放电等技术对合成产物进行物相、形貌及电化学性能分析与测试.结果表明:采用燃烧辅助合成LiNi0.05MnIn95O4过程中,前驱体在空气中点燃后已形成单一尖晶石相,经750℃热处理4h后得到的LiNi0.05Mn1.95O4粉末X射线衍射峰尖锐,结晶性好,晶粒尺寸均匀.该法合成的LiNi0.05Mn1.95O4粉末首次放电比容量为117.5 mAh·g-1,经50次充放电循环后的容量保持率为95.1%,合成的LiNi0.05Mn1.95O4粉末具有良好的电化学性能.%LiNi0.05 Mn1.95 O4 powders were prepared by combustion assisted sol-gel method using lithium acetate, manganese acetate, nickel nitrate, citric acid and ethylene glycol as starting materials. The structure, morphology, and electrochemical properties of the powders were investigated by X-ray diffraction, scanning electron microscopy, cyclic voltammetry and galvanostatic charge-discharge experiments. The results show that LiNi0.05 Mn1.95 O4 precursor gel ignited in air for several minutes has already been the structure of spinel. The powders heated at 750℃ for 4hours prepared by this technique is well crystallized. The grains are small and uniform. The specific capacity of the prepared powders is 117.5 mAh·g-1 and show the capacity retention of 95.1% after being cycled 50 times.

  14. [Structural and functional organization of the vestibular apparatus in rats maintained under weightless conditions for 19.5 days aboard the satellite "Cosmos-782"].

    Science.gov (United States)

    Vinnikov, Ia A; Gazenko, O G; Titova, L K; Bronshteĭn, A A; Govardovskiĭ, V I

    1978-01-01

    Vestibular apparatus was investigated in rats subjected to weightlessness for 19.5 days in the satelite "Cosmos-782" and experienced acceleration on launching and landing. Some structural and functional changes were noted. They were seen in otolith clinging to the utricular receptor surface and in the peripheral arrangement of the nucleolus in the nuclei of the receptor cells. It is also possible that increased edema of the vestibular tissue resulted in destruction of some receptor cells, and within the otolith--changes in the form and structure of otoconia. In the horizontal crista the cupula was separated.

  15. Structure of Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase complexed with chalepin, a natural product inhibitor, at 1.95 A resolution.

    Science.gov (United States)

    Pavão, F; Castilho, M S; Pupo, M T; Dias, R L A; Correa, A G; Fernandes, J B; da Silva, M F G F; Mafezoli, J; Vieira, P C; Oliva, G

    2002-06-01

    The structure of the glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) from Trypanosoma cruzi complexed with chalepin, a natural product from Pilocarpus spicatus, has been determined by X-ray crystallography to 1.95 A resolution. The structure is in the apo form without cofactors in the subunits of the tetrameric gGAPDH in the asymmetric unit. Unequivocal density corresponding to the inhibitor was clearly identified in one monomer. The final refined model of the complex shows extensive conformational changes when compared with the native structure. The mode of binding of chalepin to gGAPDH and its implications for inhibitor design are discussed. PMID:12044862

  16. L-1 Identity Solutions公司获得价值为1.95亿美元合约

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    身份识别解决方案供应商L-1 Identity Solutions公司获得了一份新合同,继续为美国护照提供高度安全生产系统服务。L-1 Identity Solutiotis公司的子公司Trans Digital Technologies Corporation(TDT)赢得一份潜在价值高达1.95亿美元的合约。

  17. Antiproliferative effects and mechanism of action of ICI 195,739, a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.

    OpenAIRE

    Urbina, Julia A.; Lazardi, Keyla; Aguirre, Tania; Piras, Marta M.; Piras, Romano

    1991-01-01

    The in vitro antiproliferative effects of ICI 195,739, a recently developed bis-triazole derivative (T. Boyle, D. J. Gilman, M. B. Gravestock, and J. M. Wardleworth, Ann. N.Y. Acad. Sci. 544:86-100, 1988; J. F. Ryley, S. McGregor, and R. G. Wilson, Ann. N.Y. Acad. Sci. 544:310-328, 1988), on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi and some aspects of its mechanism of action are described. Despite previous claims that triazole compounds act on susceptible organisms ...

  18. Young's Modulus Anisotropy and Magnetomechanical Damping of [110] Oriented Tb0.3Dy0.7Fe1.95 Alloy

    Institute of Scientific and Technical Information of China (English)

    PEI Yong-Mao; FANG Dai-Ning

    2007-01-01

    The AE effect and the magnetoelastic or magnetomechanical damping of vibrations in [110] oriented Tb0.3Dy0.7Fe1.95 alloy are experimentally studied by quasi-static stress-strain measurements under various constant magnetic fields between 0 and 3000 Oe, where stress ranges are taken from about 0 to -25, -50, -75MPa. The linear stress-strain behaviour is obtained when the magnetic field is high enough (9000 Oe). However, the modulus E varies with the angle θ between the compressive stress and magnetic field (9000 Oe), which shows that the anisotropy of the modulus E is related to the magnetic domain distribution.

  19. Tumor Necrosis Factor-α Induces RelA Degradation via Ubiquitination at Lysine 195 to Prevent Excessive Nuclear Factor-κB Activation*

    OpenAIRE

    Fan, Yihui; Mao, Renfang; Zhao, Yanling; Yu, Yang; Sun, WenJing; Song, Ping; Shi, Zhongcheng; Zhang, Dekai; Yvon, Eric; Zhang, Hong; Fu, Songbin; Yang, Jianhua

    2009-01-01

    Ubiquitination-mediated degradation of the RelA subunit of nuclear factor-κB (NF-κB) is critical for the termination of NF-κB activation. However, the precise mechanism for the ubiquitination of RelA is still not fully understood. Here we report that tumor necrosis factor-α (TNFα) induces RelA polyubiquitination at the lysine 195 residue, and this ubiquitination event is critical for the degradation of RelA and termination of TNFα-mediated NF-κB activation. Overexpression of a RelA mutant wit...

  20. 195例牙科患者焦虑症现状及影响因素调查研究%Studies on the status and influence factors in the 195 cases of patients with dental anxiety

    Institute of Scientific and Technical Information of China (English)

    朱丹丹; 邵永新

    2015-01-01

    目的:本论文旨在调查牙科患者焦虑症(DA )现状及影响因素,找出减轻牙科焦虑症的方法。方法采用便利抽样方法选取辽宁省朝阳市中心医院口腔科患者195例,通过基本资料、改良的牙科焦虑量表(MDAS)、状态焦虑量表(S‐AI)和两个自制的量表进行调查。结果牙科焦虑组中女性的比例高于非焦虑组(60% vs .40%,P=0.008)。多因素Logistic回归分析发现:担心医技(OR=2.247),口内喷水(OR=2.151),影响正常功能(OR=2.589),听负面经历(OR=2.825),缺乏口腔知识(OR=2.539),害怕疼痛(OR=2.074)是DA的独立危险因素;掌握口腔知识(OR=0.374),听音乐(OR=0.279),打麻药(OR=0.305),多用鼓励语言(OR=0.460)是缓解DA的独立保护因素。结论担心医技、口内喷水、影响正常功能、听负面经历、缺乏了解口腔知识、害怕疼痛都是引起DA的常见原因,学习口腔知识、听音乐、打麻药、医护人员多用鼓励的语言是有效缓解牙科焦虑症的方法。%Objective The aim of the study was to find out the status and influencing factors of dental anxiety and reduce it . Methods One hundred and ninety‐five patients in Chaoyang Central Hospital were selected via stomatology convenience sampling . Basic information ,modified dental anxiety scale(MDAS) ,State Anxiety Inventory(S‐AI) ,and two homemade scales were used to in‐vestigated .Results No difference in general baseline data was found in two groups of anxiety and non‐anxious ,except the propor‐tion of women in the group of dental anxiety was higher than non‐anxious group(60% vs .40% ,P=0 .008) .Logistic regression a‐nalysis showed that fear of bad medical technology(OR=2 .247);spray to mouth(OR=2 .151);affect normal chewing function(OR=2 .589);listen to the negative experiences(OR=2 .825);lack of knowledge of oral

  1. Magnetic-field-dependent microstructure evolution and magnetic properties of Tb0.27Dy0.73Fe1.95 alloy during solidification

    International Nuclear Information System (INIS)

    We report on the influence of magnetic field strength on the alloy Tb0.27Dy0.73Fe1.95 during slow-cooling solidification. We examined the effect of magnetic field strength on microstructure, magnetization, and magnetostrictive properties of this giant magnetostrictive alloy. We found that after field-treated solidification, the microstructure of specimens had a distinct grain arrangement and displayed magnetic anisotropy. The crystal orientation changed from random in the field-free treatment to aligned along the 〈110〉 direction in flux densities of 1 and 2.2 T, and along the easy magnetization axis 〈111〉 at a flux density of 4.4 T. In consequence, the magnetostrictive coefficient of the samples under various stresses improved with increasing magnetic flux density. Both the d33 and k33 values and the energy transformation efficiency of the field-treated specimens showed strong enhancements. - Highlights: • We investigate effect of magnetic field on microstructure and properties of Tb0.27Dy0.73Fe1.95. • The alloy shows grain arrangement and magnetic anisotropy in high magnetic fields. • The crystal orientation shows a transformation of random-- with increasing B. • The magnetostrictive coefficient at 10MP improves with increasing B. • The d33 and k33 values suggest the “jump” effect with magnetic fields

  2. Investigation on the Microstructure, Texture and Magnetostriction of Directionally Solidified Tb0.3Dy0.7Fe1.95−xVx Alloys

    Directory of Open Access Journals (Sweden)

    J. Arout Chelvane

    2012-01-01

    Full Text Available Effect of V addition on the microstructure and magnetostriction of directionally solidified Tb0.3Dy0.7Fe1.95 has been investigated. The microstructure of V added alloys (Tb0.3Dy0.7Fe1.95−xVx with x=0, 0.025, 0.05, and 0.075 indicate that Fe-50 at.% V is formed as primary phase, which subsequently undergoes spinodal decomposition. The spinodially decomposed Fe-rich phase reacts with the liquid and forms the matrix phase, (Tb,DyFe2. The V-rich spinodally decomposed product, on the other hand, exists as remnant phase without undergoing any metallurgical transformation. Texture studies indicate that the grains of (Tb,DyFe2 show 〈110〉/rotated 〈110〉 and 〈112〉 orientations for all compositions investigated in the directionally solidified condition. An improvement in magnetostriction has been noticed for small addition of V (x=0.025 and with further addition the magnetostrictive property decreases. The formation of additional phases containing vanadium is attributed to be the reason when V is added in higher concentration (x>0.025 levels.

  3. Oxygen permeation in thin, dense Ce0.9Gd0.1O 1.95- membranes II. experimental determination

    DEFF Research Database (Denmark)

    Chatzichristodoulou, Christodoulos; Søgaard, Martin; Glasscock, Julie;

    2011-01-01

    Thin (∼30 m), dense Ce0.9Gd0.1O1.95- (CGO10) membranes (5 5 cm2+) supported on a porous NiO/YSZ substrate were fabricated by tape casting, wet powder spraying and lamination. A La 0.58Sr0.4Co0.2Fe0.8O 3-δ/Ce0.9Gd0.1O1.95- (LSCF/CGO10) composite cathode was applied by screen printing. Oxygen...... compartment. The performance of the membrane was also investigated under varying CH 4 and H2O gas mixtures at 1106 K. The oxygen flux increased with decreasing steam to carbon ratio and was found to exceed 10 N mL min-1 cm-2 of O2 for steam to carbon ratios below 4:3. Post-test analysis of the tested membrane...... did not reveal any significant microstructural degradation of the CGO10 membrane or the anode-support. © 2011 The Electrochemical Society....

  4. Magnetotransport properties and magnetocaloric effects of Mn1.95Cr0.05Sb0.95Ga0.05 Compound

    Institute of Scientific and Technical Information of China (English)

    Liu Xi-Bin; Zhang Shao-Ying; Shen Bao-Gen; Yao Jin-Lei; Wang Fang

    2004-01-01

    The magnetotransport properties and magnetocaloric effects of the compound Mn1.95Cr0.05Sb0.95Ga0.05 have been studied. With decreasing temperature, a spontaneous first-order magnetic phase transition from ferrimagnetic (FI) to antiferromagnetic (AF) state takes place at Ts=200K. A metamagnetic transition from the AF to FI state can be induced by an external field, accompanied by a giant magnetoresistance effect of 57%. The magnetic entropy changes are determined from the temperature and field dependence of the magnetization using the thermodynamic Maxwell relation. Mn1.95Cr0.05Sb0.95Ga0.05 exhibits a negative magnetocaloric effect, and the absolute values of △Smax M (T, △H) are 4.4, 4.1, 3.6, 2.8 and 1.5 J/(kg.K) for magnetic field changes of 0-5T, 0-4T, 0-3T, 0-2T and 0-1T,respectively.

  5. Comparison of the IBM 370/168 MODEL 3 with the Amdahl 470V/6 and the IBM 370/195 using benchmarks

    Energy Technology Data Exchange (ETDEWEB)

    Snider, D.R.; Midlock, J.L.; Hinds, A.R.

    1977-04-01

    As part of the studies preliminary to the acquisition of additional computing capability at Argonne National Laboratory, six groups of jobs were run on the IBM 370/195 at the Applied Mathematics Division of Argonne National Laboratory, on an Amdahl 470V/6 at the Amdahl manufacturing facilities in Sunnyvale, California, and on an IBM 370/168 MODEL 3 at the IBM Field Support Center in Gaithersburg, Maryland. This report compares the performance of the IBM 370/168 MOD 3 with that of the other two machines. Differences in machine configurations were minimized. The memory size of each machine was identical, the I/O configurations were as similar as possible, and the same versions of OS/MVT 21.7 and ASP 3.1 were used on all three machines. This allowed the comparison to be based on the relative performance of the three CPUs. 15 figures, 24 tables.

  6. Effect of sintering temperature on structural and electrical properties of gadolinium doped ceria (Ce0.9Gd0.1O1.95)

    Indian Academy of Sciences (India)

    L D Jadhav; S H Pawar; M G Chourashiya

    2007-04-01

    Gadolinium doped ceria oxide is one of the promising materials as an electrolyte for IT–SOFCs. Ce0.9Gd0.1O1.95 (GDC10) powder was prepared by solid state reaction and sintered at 1473 K, 1573 K, 1673 K and 1773 K. All samples were studied using X-ray diffraction, scanning electron micrograph and d.c. conductivity measurement. The crystallinity and surface morphology of the samples improved with sintering temperature. Further, the electrical conductivity measurement indicated that the conduction mechanism is mainly ionic. The conductivity of samples sintered at 1673 K and 1773 K at 800°C are of the order of 0.1 S-cm-1. The activation energies decreased from 1.25–0.82 eV with increase in sintering temperature.

  7. InGaAs/AlInGaAs THz Quantum Cascade Lasers operating up to 195 K in strong magnetic field

    CERN Document Server

    Valmorra, Federico; Ohtani, Keita; Beck, Mattias; Faist, Jerome

    2014-01-01

    Terahertz quantum cascade lasers based on InGaAs wells and quaternary AlInGaAs barriers were measured in magnetic field. This study was carried out on a four quantum well active region design with photon energy of 14.3 meV processed both with Au and Cu waveguides. The heterostructure operates up to 148 K at B=0 T and in a Cu waveguide. The complete magneto-spectroscopic study allowed the comparison of emission and transport data. Increasing the magnetic field, the low effective mass of the InGaAs wells allowed us to reach the very strong confinement regime and at B=12 T, where the cyclotron transition is almost resonant with the LO-phonon, we recorded a maximum operating temperature of 195 K for the devices with Cu waveguide. Additional lasing at 5.9 meV was detected for a delimited range of the parameters space.

  8. 1.95  μm-pumped OP-GaAs optical parametric oscillator with 10.6  μm idler wavelength.

    Science.gov (United States)

    Wueppen, Jochen; Nyga, Sebastian; Jungbluth, Bernd; Hoffmann, Dieter

    2016-09-15

    We report on an optical parametric oscillator that generates output idler wavelengths around 10.6 μm. On the basis of orientation-patterned gallium arsenide (OP-GaAs) as a nonlinear medium and a 1.95 μm ns-pulsed pump laser, a signal-resonant bow-tie resonator was designed in order to maximize the output power at moderate intensities well below the damage threshold of the optical components. With this setup, the average idler output power at 50 kHz and 100 ns idler pulse length was more than 800 mW, which corresponds to a pulse energy of 16 μJ. The maximum quantum conversion efficiency of 36.8% is the highest value measured so far for comparable setups to the best of our knowledge.

  9. Effects of Magnetic Heat Treatment on Magnetostiction Properties of Tb0.3 Dy0.7 Fe1.95 Alloy

    Institute of Scientific and Technical Information of China (English)

    Jiang Liping; Zhao Zengqi; Wu Shuangxia; Qiu Jufeng; Sha Yuhui; Zuo Liang

    2004-01-01

    The effects of magnetic heat treatment on magnetostriction properties of Tb0.3Dy0.7Fe1.95 alloy were investigated.The directionally solidified alloy was heated to various temperatures near Curie temperature TC in vacuum, kept for a certain time under the application of magnetic field and then cooled to room temperature.The magnetostriction coefficient was measured by a resistance strain gage.The crystal structure was analyzed by X-ray diffraction (XRD).The experimental results show that the magnetostriction coefficient obviously increases and the grains orientations along the axis changed somewhat as the field of 1 T vertical to axis of the rod-shaped specimen is applied for 5 min at the heating temperature slightly lower than TC.

  10. Magnetostriction and Acoustics Properties of Tb1-xDyx(Fe1-yMny)1.95 Alloys and Their Application to Sonar Transducers

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The magnetostriction and acoustics properties of Tb1-xDyx(Fe1-yMny)1.95 alloys and their application to sonar transducers were studied. The following results were obtained from experiments. When the applied magnetic field intensity is ≥800 kA.m-1, the magnetostrictive coefficients are (1300~1800)×10-6. The electromechanical coupling factors are 0.84~0.93, the sound velocities 2168~2856 m·s-1 and the Young′s modulus (5.06~7.26)×1010 N·m-2. A sonar transducer made of the alloy rod, which has a total length of 300 mm and a total weight of 2 kg, is characterized by 2.4 kHz specified resonant frequency, 1 kHz frequency band, 173 kB current response and 45% electroacoustic efficiency.

  11. Production of high specific activity (195m) Pt-cisplatinum at South African Nuclear Energy Corporation for Phase 0 clinical trials in healthy individual subjects.

    Science.gov (United States)

    Zeevaart, Jan Rijn; Wagener, Judith; Marjanovic-Painter, Biljana; Sathekge, Mike; Soni, Nischal; Zinn, Christa; Perkins, Gary; Smith, Suzanne V

    2013-01-01

    Platinum agents continue to be the main chemotherapeutic agents used in the first-line and second-line treatments of cancer patients. It is important to fully understand the biological profile of these compounds in order to optimize the dose given to each patient. In a joint project with the Australian Nuclear Science and Technology Organisation and the Nuclear Medicine Department at Steve Biko Academic Hospital, South African Nuclear Energy Corporation synthesized and supplied (195m) Pt-cisplatinum (commonly referred to as cisplatin) for a clinical pilot study on healthy volunteers. Enriched (194) PtCl2 was prepared by digestion of enriched (194) Pt metal (>95%) followed by thermal decomposition over a 3 h period. The (194) PtCl2 was then placed in a quartz ampoule, was irradiated in SAFARI-1 up to 200 h, then decay cooled for a minimum of 34 h prior to synthesis of final product. (195m) Pt(NH3 )2 I2 , formed with the addition of KI and NH4 OH, was converted to the diaqua species [(195m) Pt(NH3 )2 (H2 O)2 ](2+) by reaction with AgNO3 . The conversion to (195m) Pt-cisplatinum was completed by the addition of concentrated HCl. The final product yield was 51.7% ± 5.2% (n = 5). The chemical and radionuclidic purity in each case was >95%. The use of a high flux reactor position affords a higher specific activity product (15.9 ± 2.5 MBq/mg at end of synthesis) than previously found (5 MBq/mg). Volunteers received between 108 and 126 MBq of radioactivity, which is equivalent to 6.8-10.0 mg of carrier cisplatinum. Such high specific activities afforded a significant reduction (~50%) in the chemical dose of a carrier cisplatinum, which represents less than 10% of a typical chemotherapeutic dose given to patients. A good manufacturing practice GMP compliant product was produced and was administered to 10 healthy volunteers as part of an ethically approved Phase 0 clinical trial. The majority of the injected activity 27.5% ± 5.8% was excreted

  12. Spatially Resolved Electronic Alterations As Seen by in Situ 195Pt and 13CO NMR in Ru@Pt and Au@Pt Core-Shell Nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Atienza, Dianne O.; Allison, Thomas C.; Tong, Yu ye J.

    2012-12-20

    Pt-based core-shell (M@Pt where M stands for core element) nanoparticles (NPs) have recently been under increasing scrutiny in the fields of fuel cell and lithium air battery electrocatalysis due to their promising prospects in optimizing catalytic activity, reducing Pt loading and consequently lowering its cost. To achieve the latter, delineating spatially resolved local (surface) elemental distribution and associated variations in electronic properties under working condition (i.e., in situ) is arguably a prerequisite of fundamental importance in investigating electrocatalysis but unfortunately is still sorely missing. In this regard, in situ 195Pt electrochemical NMR (EC-NMR) of Pt-based NPs is unique in terms of accessing such information, particularly the spatially resolved partition between the sand d-like Fermi level local density of states (Ef-LDOS) modified by the core elements. In this paper, we report a comparative in situ 195Pt EC-NMR investigation of Ru@Pt vs Au@Pt NPs which was complemented by in situ 13C EC-NMR of the 13CO adsorbed on the respective NPs generated via dissociation of methanol and by ab initio DFT calculations. The obtained results showed opposing electronic effect between Ru vs Au cores: the former reduced substantially the s-like but not the d-like Ef-LDOS of the Pt shell while the latter did the opposite. According to recent quantum calculations, a reduction in d-like partition would weaken the Pt-O bond while a reduction in s-like partition would weaken the Pt-H bond, which is largely in agreement with experimental observations.

  13. Epidemiological analysis of orthognathic surgery in a hospital in Curitiba, Brazil: Review of 195 cases Análisis epidemiológico de la cirugía ortognática en un hospital de Curitiba, Brasil: Revisión de 195 casos

    OpenAIRE

    Rafaela Scariot; Delson João da Costa; Nelson Luis Barbosa Rebellato; Paulo Roberto Müller; Roberto da Conceição Ferreira

    2010-01-01

    Objective: The present retrospective study explored the spectrum and characteristics of patients treated with orthognathic surgery at the Universidade Federal do Paraná, Brazil. Materials and method: Over a six-year period from July 2002 to July 2008, the records of 195 patients with dentofacial deformities who underwent orthognathic surgical procedures were followed up. Results: Mean patient age was 25.87 years (range 14 to 65 years) and the female to male ratio was 1.5:1. The predominant ra...

  14. Densification and grain growth kinetics of Ce0.9Gd0.1O1.95 in tape cast layers: The influence of porosity

    DEFF Research Database (Denmark)

    Ni, De Wei; Esposito, Vincenzo; Foghmoes, Søren Preben Vagn;

    2014-01-01

    The sintering behavior of Ce0.9Gd0.1O1.95(CGO) tape cast layers with different porosity was investigated by an extensive characterization of densification, microstructural evolution, and applying the constitutive laws of sintering. The densification of CGO tapes associates with grain coarsening p...

  15. Densification and grain growth during sintering of porous Ce0.9Gd0.1O1.95tape cast layers: A comprehensive study on heuristic methods

    DEFF Research Database (Denmark)

    Ni, De Wei; Schmidt, Cristine Grings; Teocoli, Francesca;

    2013-01-01

    The sintering behavior of porous Ce0.9Gd0.1O1.95(CGO10) tape cast layers was systematically investigated to establish fundamental kinetic parameters associated to densification and grain growth. Densification and grain growth were characterized by a set of different methods to determine the domin...

  16. CD30、CD195在Graves病病人131I治疗前后的表达及短期预后相关性研究

    Institute of Scientific and Technical Information of China (English)

    席文琪; 皇甫建; 肖瑞; 李彩萍; 托娅; 王成; 王春梅

    2014-01-01

    目的:本实验拟通过测定GD病人131I治疗前后外周血辅助性T淋巴细胞膜表面CD30、CD195的表达,探讨GD病人Th1/Th2平衡机制变化及其可能的临床意义。方法:选择40例GD病人和40例健康对照组为研究对象,应用流式细胞术检测GD病人131 I治疗前及治疗后6mo的外周血淋巴细胞膜表面CD195、CD30的变化以及临床症状和甲状腺功能。结果:(1)GD病人治疗前CD195显著低于健康对照组(P〈0.05);CD30高于健康对照组,CD195/CD30低于健康对照组(P〈0.01)。(2)GD病人131I治疗后6mo 34例甲亢缓解。治疗后缓解组CD195上升,CD30下降,与治疗前比较有统计学意义(P〈0.05);CD195/CD30上升,较治疗前变化显著(P〈0.01)。结论:(1)GD的发病机理与病人外周血T淋巴细胞膜中Th 1/Th 2平衡变化机制有关。(2)GD病人131I治疗缓解组Th细胞膜表面CD195、CD30及其比值的变化有助于更好的研究GD的发生机制及对疾病短期预后的判断。

  17. Prediction of (195) Pt NMR chemical shifts of dissolution products of H2 [Pt(OH)6 ] in nitric acid solutions by DFT methods: how important are the counter-ion effects?

    Science.gov (United States)

    Tsipis, Athanassios C; Karapetsas, Ioannis N

    2016-08-01

    (195) Pt NMR chemical shifts of octahedral Pt(IV) complexes with general formula [Pt(NO3 )n (OH)6 - n ](2-) , [Pt(NO3 )n (OH2 )6 - n ](4 - n) (n = 1-6), and [Pt(NO3 )6 - n  - m (OH)m (OH2 )n ](-2 + n - m) formed by dissolution of platinic acid, H2 [Pt(OH)6 ], in aqueous nitric acid solutions are calculated employing density functional theory methods. Particularly, the gauge-including atomic orbitals (GIAO)-PBE0/segmented all-electron relativistically contracted-zeroth-order regular approximation (SARC-ZORA)(Pt) ∪ 6-31G(d,p)(E)/Polarizable Continuum Model computational protocol performs the best. Excellent second-order polynomial plots of δcalcd ((195) Pt) versus δexptl ((195) Pt) chemical shifts and δcalcd ((195) Pt) versus the natural atomic charge QPt are obtained. Despite of neglecting relativistic and spin orbit effects the good agreement of the calculated δ (195) Pt chemical shifts with experimental values is probably because of the fact that the contribution of relativistic and spin orbit effects to computed σ(iso) (195) Pt magnetic shielding of Pt(IV) coordination compounds is effectively cancelled in the computed δ (195) Pt chemical shifts, because the relativistic corrections are expected to be similar in the complexes and the proper reference standard used. To probe the counter-ion effects on the (195) Pt NMR chemical shifts of the anionic [Pt(NO3 )n (OH)6 - n ](2-) and cationic [Pt(NO3 )n (OH2 )6 - n ](4 - n) (n = 0-3) complexes we calculated the (195) Pt NMR chemical shifts of the neutral (PyH)2 [Pt(NO3 )n (OH)6 - n ] (n = 1-6; PyH = pyridinium cation, C5 H5 NH(+) ) and [Pt(NO3 )n (H2 O)6 - n ](NO3 )4 - n (n = 0-3) complexes. Counter-anion effects are very important for the accurate prediction of the (195) Pt NMR chemical shifts of the cationic [Pt(NO3 )n (OH2 )6 - n ](4 - n) complexes, while counter-cation effects are less important for the anionic [Pt(NO3 )n (OH)6

  18. RILEM technical committee 195-DTD recommendation for test methods for AD and TD of early age concrete Round Robin documentation report : program, test results and statistical evaluation

    CERN Document Server

    Bjøntegaard, Øyvind; Krauss, Matias; Budelmann, Harald

    2015-01-01

    This report presents the Round-Robin (RR) program and test results including a statistical evaluation of the RILEM TC195-DTD committee named “Recommendation for test methods for autogenous deformation (AD) and thermal dilation (TD) of early age concrete”. The task of the committee was to investigate the linear test set-up for AD and TD measurements (Dilation Rigs) in the period from setting to the end of the hardening phase some weeks after. These are the stress-inducing deformations in a hardening concrete structure subjected to restraint conditions. The main task was to carry out an RR program on testing of AD of one concrete at 20 °C isothermal conditions in Dilation Rigs. The concrete part materials were distributed to 10 laboratories (Canada, Denmark, France, Germany, Japan, The Netherlands, Norway, Sweden and USA), and in total 30 tests on AD were carried out. Some supporting tests were also performed, as well as a smaller RR on cement paste. The committee has worked out a test procedure recommenda...

  19. A search for anomalous production of events with three or more leptons using 19.5/fb of sqrt(s)=8 TeV LHC data

    CERN Document Server

    CMS Collaboration

    2013-01-01

    A model-independent search for physics beyond the standard model, in events with at least three leptons, is presented. The data sample corresponds to 19.5\\,fb$^{-1}$ of integrated luminosity in pp collisions at $\\sqrt{s}=8$ TeV collected by the CMS experiment at the LHC in 2012. Data are binned in exclusive channels characterized by lepton charge and flavor combinations, the magnitude of missing transverse energy and jet activity in the event, the invariant mass of opposite-sign lepton pairs consistent or inconsistent with the decay of a $Z$ boson, and the presence or absence of b quarks and taus. The observations are consistent with expectations from standard model processes. We characterize the sensitivity of this analysis to new physics by interpreting the results in various supersymmetric models that yield multilepton final states including ones with Higgs bosons arising from supersymmetric decays. Finally, we place a 95\\% confidence level limit on the branching ratio for $t \\rightarrow ch$ decays. We fin...

  20. What Are the Trends in Tonsillectomy Techniques in Wales? A Prospective Observational Study of 19,195 Tonsillectomies over a 10-Year Period

    Science.gov (United States)

    Walijee, Hussein; Al-Hussaini, Ali; Harris, Andrew; Owens, David

    2015-01-01

    There are a multitude of techniques to undertake tonsillectomy, with hot techniques such as diathermy and coblation being associated with a higher risk of secondary haemorrhage. The UK National Prospective Tonsillectomy Audit (2004) advocated cold steel dissection and ties to be the gold standard. This prospective observational study investigates the trends in tonsillectomy techniques across Wales in the last decade to establish if surgeons have adhered to this national guidance. Data relating to tonsillectomy were extracted over a 10-year period from 1 January 2003 to 31 December 2012 from the Wales Surgical Instrument Surveillance Programme database. A total of 19,195 patients were included. Time-series analysis using linear regression showed there was an increase in the number of bipolar diathermy tonsillectomies by 84% (Pearson's r = 0.762, p = 0.010) and coblation tonsillectomies by 120% (r = 0.825, p = 0.003). In contrast, there was a fall in the number of cold steel dissection tonsillectomies with ties by 60% (r = −0.939, p coblation techniques for tonsillectomy has increased. This deviation from national guidance may be due to these techniques being faster with less intraoperative bleeding. Further study for the underlying reasons for the increase in these techniques is warranted. PMID:26693228

  1. Microhardness and fracture toughness of Ce0.9Gd0.1O1.95 for manufacturing solid oxide electrolytes

    International Nuclear Information System (INIS)

    Synthesis of nanocrystalline gadolinium doped ceria (Ce0.9Gd0.1O1.95) was attempted by nitrate-fuel combustion technique involving different organic fuels namely urea, citric acid, glycine and poly ethylene glycol. As-combusted ceria precursors were calcined at 700 deg. C for 2 h for obtaining fully dense, nanocrystalline ceria powders. Cylindrical ceria discs were fabricated by uni-axial pressing and sintered intentionally at low temperature of 1200 deg. C for 2 h for assessing the sintering characteristics of the nano powders as well as the mechanical performance of the sintered ceria body. The study confirms that the nano powders could be sintered to 98% theoretical sintered density at 1200 deg. C with a grain size of 400 nm to 1 μm. The sintered samples exhibited the Vickers microhardness of 8.82 ± 0.2 GPa and the fracture toughness of 1.75 ± 0.3 MPa m1/2 at a load 20 N for glycine and citric acid fuels derived ceria, respectively. A comparison between the fuels was made with respect to the sintering and mechanical properties of doped ceria. Citric acid and glycine fuels resulted in sintered ceria with high hardness where as the urea and polyethylene fuels derived nano ceria resulted in high fracture toughness.

  2. What Are the Trends in Tonsillectomy Techniques in Wales? A Prospective Observational Study of 19,195 Tonsillectomies over a 10-Year Period.

    Science.gov (United States)

    Walijee, Hussein; Al-Hussaini, Ali; Harris, Andrew; Owens, David

    2015-01-01

    There are a multitude of techniques to undertake tonsillectomy, with hot techniques such as diathermy and coblation being associated with a higher risk of secondary haemorrhage. The UK National Prospective Tonsillectomy Audit (2004) advocated cold steel dissection and ties to be the gold standard. This prospective observational study investigates the trends in tonsillectomy techniques across Wales in the last decade to establish if surgeons have adhered to this national guidance. Data relating to tonsillectomy were extracted over a 10-year period from 1 January 2003 to 31 December 2012 from the Wales Surgical Instrument Surveillance Programme database. A total of 19,195 patients were included. Time-series analysis using linear regression showed there was an increase in the number of bipolar diathermy tonsillectomies by 84% (Pearson's r = 0.762, p = 0.010) and coblation tonsillectomies by 120% (r = 0.825, p = 0.003). In contrast, there was a fall in the number of cold steel dissection tonsillectomies with ties by 60% (r = -0.939, p study suggests that the use of bipolar and coblation techniques for tonsillectomy has increased. This deviation from national guidance may be due to these techniques being faster with less intraoperative bleeding. Further study for the underlying reasons for the increase in these techniques is warranted.

  3. What Are the Trends in Tonsillectomy Techniques in Wales? A Prospective Observational Study of 19,195 Tonsillectomies over a 10-Year Period

    Directory of Open Access Journals (Sweden)

    Hussein Walijee

    2015-01-01

    Full Text Available There are a multitude of techniques to undertake tonsillectomy, with hot techniques such as diathermy and coblation being associated with a higher risk of secondary haemorrhage. The UK National Prospective Tonsillectomy Audit (2004 advocated cold steel dissection and ties to be the gold standard. This prospective observational study investigates the trends in tonsillectomy techniques across Wales in the last decade to establish if surgeons have adhered to this national guidance. Data relating to tonsillectomy were extracted over a 10-year period from 1 January 2003 to 31 December 2012 from the Wales Surgical Instrument Surveillance Programme database. A total of 19,195 patients were included. Time-series analysis using linear regression showed there was an increase in the number of bipolar diathermy tonsillectomies by 84% (Pearson’s r=0.762, p=0.010 and coblation tonsillectomies by 120% (r=0.825, p=0.003. In contrast, there was a fall in the number of cold steel dissection tonsillectomies with ties by 60% (r=-0.939, p<0.001. This observational study suggests that the use of bipolar and coblation techniques for tonsillectomy has increased. This deviation from national guidance may be due to these techniques being faster with less intraoperative bleeding. Further study for the underlying reasons for the increase in these techniques is warranted.

  4. Effect of cooling rate on magnetostriction gradients of Tb0.27Dy0.73Fe1.95 alloys solidified in high magnetic field gradients

    Directory of Open Access Journals (Sweden)

    Tie Liu

    2016-05-01

    Full Text Available In this work, Tb0.27Dy0.73Fe1.95 alloys were solidified in a high magnetic field gradient (8.8 T, -565 T2/m at various cooling rates. Changes in the magnetostriction, crystal orientation, and magnetization of the alloys were investigated. The application of the magnetic field gradient has a strong influence on the magnetostrictive performance. At lower cooling rates, the maximum magnetostriction increases gradually with depth from the top surface of the alloys. However, the effect of the magnetic field gradient is strongly dependent on the cooling rate. With increasing cooling rate, the magnetostriction gradient decreases. The magnetization measurement shows that the saturation magnetization at lower cooling rates increases gradually with depth from the top surface of the alloys. However, with increasing cooling rate, the increase in the saturation magnetization is reduced. The XRD measurement results show that the orientation behavior of the (Tb, DyFe2 phase exhibits a continuous change throughout the alloys at lower cooling rates, but is almost unchanged at higher cooling rates. The change in the magnetostriction of the alloys can be attributed to the changes in crystal orientation and the amount of the (Tb, DyFe2 phase in the alloys caused by both the magnetic field gradient and cooling rate.

  5. A Retrospective Analysis of 5,195 Patient Treatment Sessions in an Integrative Veterinary Medicine Service: Patient Characteristics, Presenting Complaints, and Therapeutic Interventions

    Directory of Open Access Journals (Sweden)

    Justin Shmalberg

    2015-01-01

    Full Text Available Integrative veterinary medicine, the combination of complementary and alternative therapies with conventional care, is increasingly prevalent in veterinary practice and a focus of clinical instruction in many academic teaching institutions. However, the presenting complaints, therapeutic modalities, and patient population in an integrative medicine service have not been described. A retrospective analysis of 5,195 integrative patient treatment sessions in a veterinary academic teaching hospital demonstrated that patients most commonly received a combination of therapeutic modalities (39% of all treatment sessions. The 274 patients receiving multiple modalities were most frequently treated for neurologic and orthopedic disease (50.7% versus 49.6% of all presenting complaints, resp.. Older neutered or spayed dogs (mean age = 9.0 years and Dachshunds were treated more often than expected based on general population statistics. Acupuncture, laser therapy, electroacupuncture, and hydrotherapy were frequently administered (>50% patients. Neurologic patients were more likely to receive acupuncture, electroacupuncture, and therapeutic exercises but less likely than orthopedic patients to receive laser, hydrotherapy, or therapeutic ultrasound treatments (P<0.05. The results suggest that the application of these specific modalities to orthopedic and neurologic diseases should be subjected to increased evidence-based investigations. A review of current knowledge in core areas is presented.

  6. Probing the solvent shell with 195Pt chemical shifts: density functional theory molecular dynamics study of Pt(II) and Pt(IV) anionic complexes in aqueous solution.

    Science.gov (United States)

    Truflandier, Lionel A; Autschbach, Jochen

    2010-03-17

    Ab initio molecular dynamics (aiMD) simulations based on density functional theory (DFT) were performed on a set of five anionic platinum complexes in aqueous solution. (195)Pt nuclear magnetic shielding constants were computed with DFT as averages over the aiMD trajectories, using the two-component relativistic zeroth-order regular approximation (ZORA) in order to treat relativistic effects on the Pt shielding tensors. The chemical shifts obtained from the aiMD averages are in good agreement with experimental data. For Pt(II) and Pt(IV) halide complexes we found an intermediate solvent shell interacting with the complexes that causes pronounced solvent effects on the Pt chemical shifts. For these complexes, the magnitude of solvent effects on the Pt shielding constant can be correlated with the surface charge density. For square-planar Pt complexes the aiMD simulations also clearly demonstrate the influence of closely coordinated non-equatorial water molecules on the Pt chemical shift, relating the structure of the solution around the complex to the solvent effects on the metal NMR chemical shift. For the complex [Pt(CN)(4)](2-), the solvent effects on the Pt shielding constant are surprisingly small. PMID:20166712

  7. 天津市195例3~7岁儿童神经发育评估结果分析%Analysis on the evaluation results of neurodevelopment of 195 children aged 3-7-years old in Tianjin

    Institute of Scientific and Technical Information of China (English)

    吕丛超; 席薇; 苏媛媛; 张欣

    2012-01-01

    目的:分析天津市195例3~7岁儿童的神经发育评估结果,验证格里菲斯神经发育评估量表在天津地区的适用性.方法:在天津市内3个区中选择两所公立的幼儿园和一所普通小学,采用随机抽样的方法,对195例体格检查为正常的3~7岁儿童,在征得家长知情同意后,由具有资格认证的人员采用格里菲斯神经发育评估量表进行测评.结果:量表6个领域项目的整体难度在0.66~0.78之间,随儿童生理年龄的增加,测试项目的难度逐渐降低.相关性分析显示儿童6个领域发育年龄与生理年龄之间均呈正相关(P =0.000),整体发育年龄与生理年龄之间的相关系数为0.922.3~7岁儿童总发育商平均为(110±11)分.结论:在天津地区应用格里菲斯神经发育评估量表,能够对儿童神经发育的成熟程度进行客观地评估,重新修订我国儿童的标准是必要的.%Objective: To analyze the evaluation results of neurodevelopment of 195 children aged 3-7 - years old in Tianjin, and verify the feasibility of Griffiths mental development scale in Tianjin. Methods: Two public kindergartens and a general primary school were selected from three districts of Tianjin city, random sampling method was sued to selected 195 children aged 3—7 years old with normal results of physical examination , then Griffiths mental development scale was used for assessment. Results: The total difficulties of six subscales were within 0. 66 — 0. 78 , which decreased gradually with age of children. Correlation analysis showed that there was a positive correlation between developmental ages of six suhscales and physiological age ( P = 0. 000) , the coefficient of correlation was 0. 922. The total developmental quotient of 3 — 7 — year — old children was (110±11) on average. Conclusion: Griffiths mental development scale used in Tianjin city can evaluate the mature degree of neurodevelopment of children objectively, and its

  8. Monoclonal antibody characterization of the 195-kilodalton major surface glycoprotein of Plasmodium falciparum malaria schizonts and merozoites: identification of additional processed products and a serotype-restricted repetitive epitope.

    Science.gov (United States)

    Lyon, J A; Haynes, J D; Diggs, C L; Chulay, J D; Haidaris, C G; Pratt-Rossiter, J

    1987-02-01

    The gp195 from Camp strain parasites was characterized with eight monoclonal antibodies (MAb) that recognize different epitopes on gp195 and three of its merozoite-associated processed products. Four MAb (3H7, 3B10, 7F1, and 4G12) reacted with different epitopes on the 45-kDa glycosylated product (gp45), shown by differences in their reactivities with soluble and immunoblotted gp45. One MAb (7H10) reacted with a conformational epitope probably formed as a result of the interaction of gp45 with a nonglycosylated 45-kDa product (p45). Three other MAb (3D3, 7B11, and 7B2) reacted with different epitopes on a nonglycosylated 83-kDa product (p83), shown by differences in their reactivities against various parasite isolates in immunofluorescent antibody assays. Immunoprecipitation of antigens that were pulse-labeled with [3H]isoleucine and chased with cold isoleucine showed that p45 and gp45 were processed products of gp195 and p83 was sequentially processed into smaller fragments of 73 and 67 kDa (p73 and p67). Immunoblots showed that the 7B11 and 7B2 epitopes were present on p83, p73, and p67, but that the 3D3 epitope was present only on p83 and p73. A two-site immunoassay showed the 3D3 epitope to be repetitive. The 3D3 and 7B11 epitopes were serotype restricted (present in seven and 24 of 33 isolates, respectively), but the other five epitopes were common to all isolates tested. The gp195 and its processed products have Mr that are consistent with the Mr of a number of antigens shown previously to be associated with the immune complexes that are formed when merozoites are agglutinated by antibodies contained in some growth inhibitory immune sera.

  9. CHEMICAL AND PHYSICAL CONDITIONS IN MOLECULAR CLOUD CORE DC 000.4–19.5 (SL42) IN CORONA AUSTRALIS

    International Nuclear Information System (INIS)

    Chemical reactions in starless molecular clouds are heavily dependent on interactions between gas phase material and solid phase dust and ices. We have observed the abundance and distribution of molecular gases in the cold, starless core DC 000.4–19.5 (SL42) in Corona Australis using data from the Swedish ESO Submillimeter Telescope. We present column density maps determined from measurements of C18O (J = 2-1, 1-0) and N2H+ (J = 1-0) emission features. Herschel data of the same region allow a direct comparison to the dust component of the cloud core and provide evidence for gas phase depletion of CO at the highest extinctions. The dust color temperature in the core calculated from Herschel maps ranges from roughly 10.7 to 14.0 K. This range agrees with the previous determinations from Infrared Space Observatory and Planck observations. The column density profile of the core can be fitted with a Plummer-like density distribution approaching n(r) ∼ r –2 at large distances. The core structure deviates clearly from a critical Bonnor-Ebert sphere. Instead, the core appears to be gravitationally bound and to lack thermal and turbulent support against the pressure of the surrounding low-density material: it may therefore be in the process of slow contraction. We test two chemical models and find that a steady-state depletion model agrees with the observed C18O column density profile and the observed N(C18O) versus AV relationship.

  10. Insights into the fine-grained fraction of serpentine mud from the Southern Chamorro seamount (ODP Leg 195): A combined XRD, RFA and TEM-EDS study

    Science.gov (United States)

    Lischka, M.; Meschede, M.; Warr, L. N.

    2009-12-01

    Serpentine mud volcanoes in the outer forearc of the Izu-Bonin-Mariana subduction system occur in a restricted zone, 50km - 120 km away from the trench axis [Fryer et al., 1985]. The morphotectonic elements of the forearc are dominated by horst and graben structures, caused by extensional movements and normal fault systems related to seamount subduction [Fryer et al., 2000; Stern and Smooth, 1998]. These faults may provide conduits for the diapiric uprising of low density serpentine, extruding at the seafloor in stratovolcanic like structures. Released fluids from the subducted slab at estimated depths of approximately 30km are considered to hydrate the forearc mantle wedge along those fractures [Benton et al., 2001; Mottl et al., 2003; Rübke et al., 2004]. During the formation of the fault gouge, serpentine-bodies entrained xenoliths and xenocrysts from the surrounding rocks and are exhumed towards the surface [Fryer et al., 1990]. In our investigation we focus on the silty to clay-sized particle fraction of the serpentine mud matrix, drilled during ODP Leg 195 at site 1200E. We analysed the bulk mineral composition with X-ray diffraction methods on random powder samples, supplemented by X-ray fluorescence measurements on 25 samples. To obtain more insights into the mineralogy fabric and microstructure of the samples, electron microscopy and electron dispersive spectroscopy were used to determine the crystal-chemistry and alteration textures. Particular emphasis was given on determining serpentine polymorphs and the nature of other phyllosilicates and their geochemical composition and constraints. Geochemical observation of the secondary mineral phases should allow us to reconstruct the processes linked with the migration of fluids and volatile components during subduction related metamorphism affecting the mantle wedge. Based on the new data we characterize the conditions of alteration products within a subduction factory, related to the diapiric deposition of

  11. CLASSIFICATION OF NECK/SHOULDER PAIN IN EPIDEMIOLOGICAL RESEARCH: A COMPARISON OF PERSONAL AND OCCUPATIONAL CHARACTERISTICS, DISABILITY AND PROGNOSIS AMONG 12,195 WORKERS FROM 18 COUNTRIES

    Science.gov (United States)

    Sarquis, Leila M M; Coggon, David; Ntani, Georgia; Walker-Bone, Karen; Palmer, Keith T; Felli, Vanda E; Harari, Raul; Barrero, Lope H; Felknor, Sarah A.; Gimeno, David; Cattrell, Anna; Vargas-Prada, Sergio; Bonzini, Matteo; Solidaki, Eleni; Merisalu, Eda; Habib, Rima R.; Sadeghian, Farideh; Kadir, M Masood; Warnakulasuriya, Sudath SP; Matsudaira, Ko; Nyantumbu, Busisiwe; Sim, Malcolm R; Harcombe, Helen; Cox, Ken; Marziale, Maria H; Harari, Florencia; Freire, Rocio; Harari, Natalia; Monroy, Magda V; Quintana, Leonardo A; Rojas, Marianela; Harris, E Clare; Serra, Consol; Martinez, J Miguel; Delclos, George; Benavides, Fernando G; Carugno, Michele; Ferrario, Marco M; Pesatori, Angela C; Chatzi, Leda; Bitsios, Panos; Kogevinas, Manolis; Oha, Kristel; Freimann, Tiina; Sadeghian, Ali; Peiris-John, Roshini J; Sathiakumar, Nalini; Wickremasinghe, A Rajitha; Yoshimura, Noriko; Kelsall, Helen L; Hoe, Victor C W; Urquhart, Donna M; Derrett, Sarah; McBride, David; Herbison, Peter; Gray, Andrew; Vega, Eduardo J. Salazar

    2016-01-01

    To inform case-definition for neck/shoulder pain in epidemiological research, we compared levels of disability, patterns of association and prognosis for pain that was limited to the neck or shoulders (LNSP) and more generalised musculoskeletal pain that involved the neck or shoulder(s) (GPNS). Baseline data on musculoskeletal pain, disability and potential correlates were collected by questionnaire from 12,195 workers in 47 occupational groups (mostly office workers, nurses, and manual workers) in 18 countries (response rate = 70%). Continuing pain after a mean interval of 14 months was ascertained through a follow-up questionnaire in 9,150 workers from 45 occupational groups. Associations with personal and occupational factors were assessed by Poisson regression and summarised by prevalence rate ratios (PRRs). The one-month prevalence of GPNS at baseline was much greater than that of LNSP (35.1% vs. 5.6%), and it tended to be more troublesome and disabling. Unlike LNSP, the prevalence of GPNS increased with age. Moreover, it showed significantly stronger associations with somatising tendency (PRR 1.6 vs. 1.3) and poor mental health (PRR 1.3 vs. 1.1); greater variation between the occupational groups studied (prevalence ranging from 0% to 67.6%) that correlated poorly with the variation in LNSP; and was more persistent at follow-up (72.1% vs. 61.7%). Our findings highlight important epidemiological distinctions between sub-categories of neck/shoulder pain. In future epidemiological research that bases case definitions on symptoms, it would be useful to distinguish pain which is localised to the neck or shoulder from more generalised pain that happens to involve the neck/shoulder region. PMID:26761390

  12. Influence of citric acid contents on nano cathode material LiCo0.05Mn1.95O4%柠檬酸含量对纳米正极材料LiCo0.05Mn1.95O4的影响

    Institute of Scientific and Technical Information of China (English)

    韩恩山; 王硕; 朱令之; 徐慧

    2012-01-01

    The content of the chelating agents have a great impact on the electrochemical properties of materials by the sol-gel method.Cobalt-doped lithium manganese oxide spinel LiCO0.05Mn1.95O4 powder was synthesized by citric acid sol-gel method.The influence of citric acid content on the structure and electrochemical properties of materials was investigated by XRD,SEM,constant current charge and discharge,electrochemical impedance spectroscopy (EIS) and cyclic voltammetry(CV) experiments.The charge-discharge results show that the material possesses good electrochemical properties when the molar ratio of citric acid to total metal ton is 1 :1;at the rate of 0.1 C current and cutoff voltage of 3.0-4.3 V,LiCO0.05Mn1.95O4 powder possesses the initial and stable discharge specific capacity of 120.7 and 118.2 mAh/g after 10 cycles,respectively,while at the rate 1 C current,the stable discharge specific capacity is about 80 mAh/g after 20 cycles.The SEM shows that the material is nanoscale.%在溶胶凝胶法中,螯合剂的含量对材料的性能有较大的影响.采用柠檬酸溶胶凝胶法制备了尖昌石掺钴锰酸锂LiCo0.05Mn1.95O4粉末.利用X射线衍射光谱法(XRD)、扫描电子显微镜法(SEM)、恒流充放电、电化学阻抗(EIS)、循环伏安(CV)等分析方法研究了柠檬酸含量对材料的结构和电化学性能的影响.充放电结果表明,当柠檬酸和总金属离子摩尔比为1∶1时制备出的材料具有良好的电化学性能;在3.0~4.3V之间进行充放电,0.1 C下,材料首次放电比容量达到120.7mAh/g,循环10次后保持在118.2 mAh/g,1 C下循环20次后放电比容量保持在80 mAh/g左右.SEM表明材料是纳米级别.

  13. Hydrogen absorption in Mg1.95Ti0.05Ni0.95Cu0.05 alloy prepared with mechanical alloying and thermal treatment; Absorcion de hidrogeno en la aleacion Mg1.95Ti0.05Ni0.95Cu0.05 preparada por aleado mecanico y tratamiento termico

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, Juan Bonifacio; Urena Nunez, Fernando [Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Estado de Mexico (Mexico)]. E-mail: juan.bonifacio@inin.gob.mx

    2009-09-15

    This work presents hydrogen absorption in quaternary alloy Mg1.95Ti0.05Ni0.95Cu0.05 obtained by the mechanical alloying method, followed by thermal treatment in ultra-high pure argon atmosphere. The composition of the phases, microstructure and morphology of ground powders and with thermal treatment were characterized by DRX, SEM/EDS and TEM. After 20 hours of mechanical grinding and recooked at 300 degrees Celsius/1h in argon atmosphere, the quaternary alloy has a Mg{sub 2}Ni crystalline hexagonal structure with a crystallite size under 10 nm. The absorption measurements were performed under a pressure of 0.2 to 1.2 MPa at a temperature of 200 degrees Celsius in a micro-reactor. The quantification of absorption-desorption of hydrogen in the intermetallic was conducted in a TGA-DSC simultaneous calorimeter. Metallic hydride-dehydride powder was characterized with SEM and XRD. [Spanish] En este trabajo se presenta la absorcion de hidrogeno en la aleacion cuaternaria Mg1.95Ti0.05Ni0.95Cu0.05 obtenida por el metodo de aleado mecanico, seguida de tratamiento termico en atmosfera de argon de ultra alta pureza. La composicion de las fases, microestructura y morfologia de los polvos molidos y con tratamiento termico fue caracterizada por DRX, SEM/EDS y TEM. Despues de 20 h de molienda mecanica con recocido a 300 grados Celsios/1h en atmosfera de argon, la aleacion cuaternaria tiene una estructura cristalina hexagonal Mg{sub 2}Ni con tamano de cristalito menor a 10 nm. Las mediciones de absorcion fueron realizadas bajo una presion de 0.2 a 1.2 MPa a una temperatura de 200 grados Celsios en un micro-reactor. La cuantificacion de absorcion-desorcion de hidrogeno en el intermetalico se realizo en un calorimetro simultaneo TGA-DSC. Se determino que la cantidad maxima absorbida de hidrogeno en la aleacion cuaternaria fue de 3.24% en peso cuando la presion fue de 0.8 MPa a dicha temperatura. Polvos metalicos hidrurados-deshidrurados se caracterizaron por SEM y XRD.

  14. Identification of aquifer limits inside an Andean Piedmont (between 19,5°S and 20°S - Northern Chile) with TDEM and gauging methods.

    Science.gov (United States)

    Viguier, Benoit; Jourde, Hervé; Leonardi, Véronique; Moya, Claudio; Líra, Elias; Yáñez, Gonzalo; Maringue, José; García-Pérez, Tiaren; Lictevout, Elisabeth

    2016-04-01

    In times of brutal climate changes and water scarcity in arid areas, the management of water resource has become a major issue. In this aim, several studies attempted to quantify the aquifer recharge and hydrodynamic processes. However, the quality of many studies depends on the characterization of aquifer boundaries. In arid areas, the amount of observation points (e.g. wells) and their spatial distribution constrain the understanding of aquifer boundaries spatial variations. In this study, we propose a methodology to characterize both water table level and boundaries of aquifer in such areas where the observation points do not exist. The Andean Piedmont (between 19,5°S and 20°S - Northern Chile) is located in the Pampa del Tamarugal Central Depression and is bounded respectively at the westside and the eastside by the Coastal Cordillera (1100 m a.s.l) and the Precordillera mountain range (4500 m a.s.l). The piedmont and the basin floor are composed of the late-Cenozoic alluvial deposits (hundred meters thick) which contain the Pampa del Tamarugal aquifer. Due to the hyperarid context, this regional aquifer is one of the main strategic groundwater resources in Northern Chile. This aquifer is mainly unconfined and the electrical conductivity of groundwater varies around 3000 μS/cm in the study area. The analysis of resistivity variation with depth, acquired by Time Domain Electromagnetic (TDEM) method in various points inside the piedmont, allow identifying a continuous resistivity contrast (from ≥ 100-40 Ω.m to ≤ 10 Ω.m) that varies over the study area. This continuous resistivity contrast is assumed to be related to the water table of the unconfined aquifer rather than to a lithology contrast. After validation of the observations, a piezometric map was constructed using both the available hydrogeological information and the TDEM results. In the piedmont, river sink were identified; these zones where surface water sinks are correlated with the resistivity

  15. Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome

    Science.gov (United States)

    Deschler, Barbara; Ihorst, Gabriele; Platzbecker, Uwe; Germing, Ulrich; März, Eva; de Figuerido, Marcelo; Fritzsche, Kurt; Haas, Peter; Salih, Helmut R.; Giagounidis, Aristoteles; Selleslag, Dominik; Labar, Boris; de Witte, Theo; Wijermans, Pierre; Lübbert, Michael

    2013-01-01

    Myelodysplastic syndromes and acute myeloid leukemia exemplify the complexity of treatment allocation in older patients as options range from best supportive care, non-intensive treatment (e.g. hypomethylating agents) to intensive chemotherapy/hematopoietic cell transplantation. Novel metrics for non-disease variables are urgently needed to help define the best treatment for each older patient. We investigated the feasibility and prognostic value of geriatric/quality of life assessments aside from established disease-specific variables in 195 patients aged 60 years or over with myelodysplastic syndromes/acute myeloid leukemia. These patients were grouped according to treatment intensity and assessed. Assessment consisted of eight instruments evaluating activities of daily living, depression, mental functioning, mobility, comorbidities, Karnofsky Index and quality of life. Patients with a median age of 71 years (range 60-87 years) with myelodysplastic syndromes (n=63) or acute myeloid leukemia (n=132) were treated either with best supportive care (n=47), hypomethylating agents (n=73) or intensive chemotherapy/hematopoietic cell transplantation (n=75). After selection of variables, pathological activities of daily living and quality of life/fatigue remained highly predictive for overall survival in the entire patient group beyond disease-related risk factors adverse cytogenetics and blast count of 20% or over. In 107 patients treated non-intensively activities of daily living of less than 100 (hazard ratio, HR 2.94), Karnofsky Index below 80 (HR 2.34) and quality of life/’fatigue’ of 50 or over (HR 1.77) were significant prognosticators. Summation of adverse features revealed a high risk of death (HR 9.36). In-depth evaluation of older patients prior to individual treatment allocation is feasible and provides additional information to standard assessment. Patients aged 60 years or over with newly diagnosed myelodysplastic syndromes/acute myeloid leukemia and

  16. Studies on the percolation limit of Ce0.9Gd0.1O1.95 in La0.6Sr0.4Co0.2Fe0.8O3-δ-Ce0.9Gd0.1O1.95 nanocomposites for solid oxide fuel cells application

    Science.gov (United States)

    Jamale, Atul P.; Jadhav, S. T.; Dubal, S. U.; Bhosale, C. H.; Jadhav, L. D.

    2015-10-01

    A large difference in thermal expansion coefficient of electrode and electrolyte leads to imperfect electrode/electrolyte interface and hence significant polarization losses in solid oxide fuel cells. To overcome the difficulties associated with electrode and electrode/electrolyte interface, there is need to fabricate the composite cathode. Thus the present paper deals with study of La0.6Sr0.4Co0.2Fe0.8O3-δ(LSCF)-Ce0.9Gd0.1O1.95(GDC) nanocomposite with different fractions of GDC obtained by physical mixing of combustion synthesized nanopowders. No secondary phases were observed upon sintering at 1100 °C for 2 h affirming the chemical compatibility between LSCF and GDC. The composites with relatively high GDC% have higher density as a consequence of rapid grain growth and less conductivity. The nanocomposite with 50% of GDC showed electric conductivity of 30 Scm-1 at 500 °C and low area specific resistance of 106 Ω cm2 with 10 μs relaxation time at 200 °C.

  17. A study of magnetostriction, spin reorientation, and Mssbauer spectra of Tb0.3Dy0.6Pr0.1(Fe1-xAlx)1.95 alloys with substitution of Fe by Al

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The effects of Al substitution for Fe on the structure, magnetics, magnetostriction, anisotropy and spin reorientation of a series of Tb0.3Dy0.6Pr0.1(Fe1-xAlx)1.95 alloys (x=0.05, 0.1, 0.15, 0.2, 0.25, 0.3) at room temperature have been investigated. The alloys of Tb0.3Dy0.6Pr0.1(Fe1-xAlx)1.95 substantially retain MgCu2-type C-15 cubic Laves phase structure when x<0.2. The mixed phases appear with x = 0.2, and cubic Laves phase decreases with increasing x. The magnetostriction of the Tb0.3Dy0.6Pr0.1(Fe1-xAlx)1.95 alloys decreases drastically with increasing x and the giant magnetostrictive effect disappears for x > 0.15. Fortunately, a small amount of Al substitution is beneficial to a decrease in the magnetocrystalline anisotropy. The spin reorientation temperature decreases with increasing x. The analysis of the Mssbauer spectra indicates that the easy magnetization direction in the {110} plane deviates slightly from the main axis of symmetry with the increase of Al concentration x, namely, spin reorientation, resulting in the change of macroscopical magnetic properties and magnetostriction. The hyperfine field decreases, but the isomer shifts increases with Al concentration increasing and the quadruple splitting QS shows a weak concentration dependence.

  18. Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.

    Science.gov (United States)

    Kong, Leopold; Torrents de la Peña, Alba; Deller, Marc C; Garces, Fernando; Sliepen, Kwinten; Hua, Yuanzi; Stanfield, Robyn L; Sanders, Rogier W; Wilson, Ian A

    2015-10-01

    The HIV-1 envelope gp160 glycoprotein (Env) is a trimer of gp120 and gp41 heterodimers that mediates cell entry and is the primary target of the humoral immune response. Broadly neutralizing antibodies (bNAbs) to HIV-1 have revealed multiple epitopes or sites of vulnerability, but mapping of most of these sites is incomplete owing to a paucity of structural information on the full epitope in the context of the Env trimer. Here, a crystal structure of the soluble BG505 SOSIP gp140 trimer at 4.6 Å resolution with the bNAbs 8ANC195 and PGT128 reveals additional interactions in comparison to previous antibody-gp120 structures. For 8ANC195, in addition to previously documented interactions with gp120, a substantial interface with gp41 is now elucidated that includes extensive interactions with the N637 glycan. Surprisingly, removal of the N637 glycan did not impact 8ANC195 affinity, suggesting that the antibody has evolved to accommodate this glycan without loss of binding energy. PGT128 indirectly affects the N262 glycan by a domino effect, in which PGT128 binds to the N301 glycan, which in turn interacts with and repositions the N262 glycan, thereby illustrating the important role of neighboring glycans on epitope conformation and stability. Comparisons with other Env trimer and gp120 structures support an induced conformation for glycan N262, suggesting that the glycan shield is allosterically modified upon PGT128 binding. These complete epitopes of two broadly neutralizing antibodies on the Env trimer can now be exploited for HIV-1 vaccine design. PMID:26457433

  19. Dynamics analysis of S195 diesel engine crank connecting rod mechanism%S125柴油机曲柄连杆机构的动力学分析

    Institute of Scientific and Technical Information of China (English)

    姜晓溪; 刘鎏

    2015-01-01

    Gained the dynamic force curve of every connect position relative to crank angle. Through analysis of simulation results,found the center mass of crank and linear eccentricity have big influence to piston side pressure and inertia force. Based on this analysis conclusion,optimized of the crank-link structure of S195 diesel engine. The maximum value of piston side pressure decreased 35%and mechanism inertia force decreased 22%after optimization. The simulation result also show that the mass replace method have computational error because ignored the inertia force of rod. The research displayed a convenience and method of mechanical design. Wil provided some experience for large-scale simulation research and dynamic finite element Analysis in the future.%本文在曲柄连杆机构理论分析的基础上,通过质量替换法,利用多体动力学理论,Matlab程序设计语言对内燃机曲柄连杆机构的动力学问题进行了编程计算分析。并以S195柴油机为研究对象,对额定工况下S195柴油机的曲柄连杆机构的动力学公式进行了编程计算,绘制出机构动态力随曲轴转角的变化曲线。并改变参数对曲线进行分析比较,通过比较分析,发现曲柄连杆机构的连杆比、偏心距及曲轴质心位置对机构中的动态力有较大影响。在此基础上对S195柴油机曲柄连杆机构进行理论研究,优化后的机构中活塞对气缸壁侧压力值降低,往复惯性力值可降低。通过本文的研究,展示了一种简捷、高效的机械设计分析手段,对今后同类型的研究乃至更大规模的仿真分析积累了一些经验。

  20. High performance and highly durable infiltrated cathodes using Pr-modified Ce0.9Gd0.1O1.95 backbone

    DEFF Research Database (Denmark)

    Samson, Alfred Junio; Søgaard, Martin; Bonanos, Nikolaos;

    2014-01-01

    Infiltration of electrocatalysts into ionic conducting backbones (e.g. Sr – doped LaCoO3 (LSC) into Ce0.9Gd0.1O1.95 (CGO)) is becoming a widely popular means of preparing composite cathodes for SOFCs. The high surface area nanoparticle grains of the electrocatalyst obtained using the method...... the CGO backbone with Pr through infiltration into the structure followed by firing. The Pr – modified CGO backbone is then infiltrated with LSC. The electrochemical performance of the infiltrated cathodes with and without Pr modification in the backbone was studied by impedance spectroscopy on symmetric...

  1. Magnetostriction, spin reorientation and Mssbauer study of Tb0.3Dy0.7(Fe1-xAlx)1.95 intermetallic compounds%Tb0.3Dy0.7(Fe1-xAlx)1.95合金的磁致伸缩、自旋重取向和穆斯堡尔谱研究

    Institute of Scientific and Technical Information of China (English)

    郑小平; 薛德胜; 李发伸; 成昭华; 吴光恒; 沈保根

    2002-01-01

    系统研究了室温下Tb0.3Dy0.7(Fe1-xAlx)1.95(x=0,0.05,0.1,0.15,0.2,0.25,0.3,0.35)合金中金属Al替代Fe对晶体结构、磁致伸缩、各向异性和自旋重取向的影响.结果发现,x0.15时超磁致伸缩效应消失;x0.15时,合金在室温下呈现顺磁性.

  2. Epidemiological analysis of orthognathic surgery in a hospital in Curitiba, Brazil: Review of 195 cases Análisis epidemiológico de la cirugía ortognática en un hospital de Curitiba, Brasil: Revisión de 195 casos

    Directory of Open Access Journals (Sweden)

    Rafaela Scariot

    2010-12-01

    Full Text Available Objective: The present retrospective study explored the spectrum and characteristics of patients treated with orthognathic surgery at the Universidade Federal do Paraná, Brazil. Materials and method: Over a six-year period from July 2002 to July 2008, the records of 195 patients with dentofacial deformities who underwent orthognathic surgical procedures were followed up. Results: Mean patient age was 25.87 years (range 14 to 65 years and the female to male ratio was 1.5:1. The predominant racial group was "white". Most patients belonged to the economically productive population. Sixty-two patients had complete dentition. Only 3.59% patients had local anesthesia (rapid palatal expansion. Transverse maxillary deficiency was the most common deformity, followed by maxillary anteroposterior deficiency associated with mandibular anteroposterior excess. Mandibular set-back was the intervention most frequently performed. The surgical procedures took an average of 3 hours 51 minutes and orthodontic treatments took an average of 44.48 months. Complications occurred in 22.57% of patients, the most common of which were permanent paresthesia of the lower lip (7.17% and inadequate fracture reduction (5.12%. Conclusions: The findings included concepts that were useful for characterizing the profile of patients who undergo orthognathic surgery in southern Brazil. The results also may help to correctly develop protocols for patient care designed to improve the overall results of the procedures.Objetivo: Este estudio retrospectivo explora el espectro y las características de los pacientes tratados con cirugía ortognática en la Universidade Federal do Paraná. Material y método: A lo largo de 6 años, a partir de julio de 2002 hasta julio de 2008, se efectuó el seguimiento de 195 pacientes con deformidades dentofaciales que se sometieron a procedimientos de cirugía ortognática. Resultados: La edad media de los pacientes fue de 25,87 años (de 14 a 65 y la

  3. Influence of a platinum functional layer on a Ni-Ce{sub 0.9}Gd{sub 0.1}O{sub 1.95} anode for thin-film solid oxide fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Sungmin; Cha, Suk Won, E-mail: ybkim@hanyang.ac.kr, E-mail: swcha@snu.ac.kr [Department of Mechanical and Aerospace Engineering, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 151-744 (Korea, Republic of); Chang, Ikwhang [Graduate School of Convergence Science and Technology, Seoul National University, 864-1, Iui-dong, Yeongtong-gu, Suwon, Gyeonggi-do 443-270 (Korea, Republic of); Kim, Young-Beom, E-mail: ybkim@hanyang.ac.kr, E-mail: swcha@snu.ac.kr [Department of Mechanical Engineering, Hanyang University, 222 Wangshimni-ro, Seongdong-gu, Seoul 133-791 (Korea, Republic of)

    2015-09-15

    A Pt functional layer was deposited between a Ni-Ce{sub 0.9}Gd{sub 0.1}O{sub 1.95} (50 wt. % Ni) anode and an 8 mol. % yttria-stabilized zirconia electrolyte in order to enhance the performance of a thin film solid oxide fuel cell. By inserting this ultrathin functional layer, the ohmic impedance of the single cell was significantly reduced, and the maximum power density was increased by a factor of ∼1.55. However, excessive deposition of the Pt functional layer caused ionic conduction pathway blocking between the yttria-stabilized zirconia and Ni-Gd{sub 0.1}Ce{sub 0.9}O{sub 1.95} (Ni-GDC), deactivating the Ni-GDC as a mixed ionic and electronic conducting anode. As a result, both the ohmic impedance and anodic faradaic impedance were increased after introduction of excessive Pt functional layer, and the maximum power density was also reduced.

  4. 磁感应强度和冷却速率对Tb0.27Dy0.73Fe1.95合金凝固过程中取向行为的影响∗%Influence of magnetic flux density and co oling rate on orientation behavior of Tb0.27Dy0.73Fe1.95 alloy during solidification pro cess

    Institute of Scientific and Technical Information of China (English)

    高鹏飞; 刘铁; 柴少伟; 董蒙; 王强

    2016-01-01

    实验研究了磁感应强度和冷却速率对Tb0.27 Dy0.73 Fe1.95合金凝固过程中(Tb, Dy)Fe2相取向行为及合金磁性能的影响.结果表明,将强磁场作用于Tb0.27Dy0.73Fe1.95合金的凝固过程可以制备出(Tb, Dy)Fe2相沿⟨111⟩取向的组织,同时显著提高了合金的磁致伸缩性能;通过提高磁感应强度可以在更快的冷却速率下得到⟨111⟩取向的组织;在4—10 T范围内,随着冷却速率的增加,(Tb, Dy)Fe2相沿⟨111⟩取向所需的磁感应强度增加,而发生⟨110⟩取向的磁感应强度减小.随着冷却速率的增加,合金的饱和磁化强度增加,而强磁场的施加对合金饱和磁化强度的变化没有明显影响.(Tb, Dy)Fe2相的取向行为受(Tb, Dy)Fe3相取向行为的影响,且由磁晶各向异性能与磁场作用时间共同控制.%The rare-earth giant magnetostrictive material Tb0.27Dy0.73Fe1.95 is one of the most important functional magnetic materials. Their superior properties include high saturation magnetostrictive coefficient at room temperature, high electromechanical coupling coefficients, high output power, fast response, high energy density, and non-contact drive. Thus, they can be used to build sensors, precision machinery, magnetomechanical transducers, and adaptive vibration-control systems. In this material, the magnetic phase (Tb, Dy)Fe2 has a typical MgCu2-type cubic Laves phase structure and exhibits different magnetostrictive properties along different crystal orientations. The ⟨111⟩ direction of this phase is the easy magnetization axis, along which the linear magnetostriction is higher than other directions. Thus, researchers have focused on preparing (Tb, Dy)Fe2 with a crystallographic orientation along or close to the⟨111⟩direction. Generally, the directional solidification method is used to prepare the Tb0.27Dy0.73Fe1.95 alloy. However, a crystal orientated along the ⟨110⟩ or ⟨112⟩ direction is always obtained and both of

  5. 铜-钢-铜三层复合板室温轧制成形工艺及结合机制的研究%The Study of the Compound Technology and Bond Mechanism Copper Alloy/Q195/Copper Alloy Three-ply Cladding Sheet

    Institute of Scientific and Technical Information of China (English)

    于宝义; 安振之; 齐克敏

    2001-01-01

    研究了铜合金-Q195-铜合金三层复合板室温轧制成形工艺,借助金相显微镜、扫描电镜、电子探针分析了复合板的结合机制。%The study was carried out on the compound technology of copper alloy/Q195/copper alloy cladding sheet,with room temperature rolling deformation.The bond mechanism of compound sheet was analysed by using optical,scanning electron microscope,electron probe.

  6. La reforma realizada en el año 2002 al artículo 195 de la constitución política: La posibilidad de someter a referéndum una reforma constitucional

    Directory of Open Access Journals (Sweden)

    Esteban Alfaro Calderón

    2008-01-01

    Full Text Available Análisis de la reforma realizada al inciso 8 del artículo 195 de la Constitución Política en el año 2002; sobre la posibilidad de someter a referéndum las reformas constitucionales después de ser aprobadas en una legislatura y antes de la siguiente, esto si dos terceras partes de los miembros de la Asamblea así lo acuerdan. Hace un estudio desde la perspectiva de quienes la apoyan, así como de sus detractores. Adicionalmente realiza una investigación de doctrina y jurisprudencia de la Sala Constitucional y del Tribunal Supremo de Elecciones, en lo que al referéndum y al principio de participación se refiere.

  7. Influence of porosity on densification and grain growth kinetics of Ce0.9Gd0.1O1.95 tape

    DEFF Research Database (Denmark)

    Ni, De Wei; Esposito, Vincenzo; Foghmoes, Søren Preben Vagn;

    determined from master viscosity curves, which are comparable to the kinetic values obtained from densification and grain growth. It is indicated that porosity has negligible effect on densification kinetics, but high porosity decreases the chance of particle contact, and grain boundary mobility is therefore...... is accompanied by the change of shape, size and fraction of pores in a given volume. Therefore, porosity can be treated as an extra phase during sintering study. In this work, we presented the densification and grain growth behaviour of Ce0.9Gd0.1O1.95 tape cast layers with different percentage of...... porosity. The emphasis was put on the effect of porosity on densification and grain growth kinetics. Derived from the sintering constitutive laws, the densification and grain growth kinetics were experimentally characterized and analyzed. Furthermore, the activation energies for viscous flow were...

  8. Impedance Spectroscopy and Catalytic Activity Characterization of a La0.85Sr0.15MnO3/Ce0.9Gd0.1O1.95 Electrochemical Reactor for the Oxidation of Propene

    DEFF Research Database (Denmark)

    Ippolito, Davide; Kammer Hansen, Kent

    2014-01-01

    This study aims to characterize the catalytic and electrochemical behavior of a La0.85Sr0.15MnO3/Ce0.9Gd0.1O1.95 porous reactor for the oxidation of propene in the presence of oxygen. The application of anodic polarization strongly increased the propene oxidation rate up to 71 %, although...... the current efficiency remained low. The effect of prolonged polarization on the reactor catalytic activity was evaluated. Prolonged polarization enhanced both the reactor intrinsic catalytic activity and the electrode performance due to the formation of oxygen vacancies on the electrode surface....... Electrochemical impedance spectroscopy was used to investigate the effect of propene introduction on the reactor impedance response. The introduction of propene into reactive system caused a strong increase of electrode resistance, mainly located in the low-frequency region of the impedance spectrum. This effect...

  9. Electrochemical performance and stability of nano-particulate and bi-continuous La1-XSrXCoO3 and Ce0.9Gd0.1O1.95 composite electrodes

    DEFF Research Database (Denmark)

    Hjalmarsson, Per; Hallinder, Jonathan; Mogensen, Mogens Bjerg

    2012-01-01

    A bi-continuous porous cathode consisting of nano-particles of strontium substituted lanthanum cobaltite (LSC) covering the surface of a Ce0.9Gd0.1O1.95 (CGO10) backbone has been produced. The polarization resistance (R (P)) of this cathode was measured to similar to 35 m Omega cm(2) at 650...

  10. Retrospective analysis of 195 cases of acute exacerbation of bronchial asthma in children%不同年龄儿童支气管哮喘急性发作的对比分析

    Institute of Scientific and Technical Information of China (English)

    朱赟; 王亚亭

    2012-01-01

    目的 探讨不同年龄组哮喘急性发作儿童的临床特点.方法 回顾性分析2006年1月至2010年12月住院195例哮喘急性发作患儿的临床资料,比较5岁前和5岁后2个年龄组患儿的临床特点.结果 2组比较,<5岁组患儿具有血小板计数高、住院时间长、合并肺炎及支原体感染率高,过去1年喘息发作的次数多,哮喘及时诊断和治疗率低的特点(P<0.05).结论 <5岁组患儿在哮喘急性发作时表现较重,更易并发肺炎和支原体感染,哮喘及时诊断率较低,治疗依从性较差.%Objective To explore the clinical features of different age groups ( <5 years old and ≥5 years old ) of children with a-cute exacerbation of asthma. Methods The clinical data concerning 195 cases of hospitalization children with acute exacerbation of asthma between Jan. 2006 to Dec. 2010 were retrospectively reviewed, and their clinical features were comparied. Results Comparing with ≥5 years old groups, <5 years of age group of children have higher platelet count, longer hospital stay, higher pneumonia , mycoplasma infection rate, more times of wheezing in the past year, low diagnosis rate of asthma and low treatment (P <0. 05 ). Conclusion <5 years of age group of children,who have stronger inflammatory response, are easy to suffer from pneumonia and mycoplasma infection, and very few of them can be diagnosed timely and treated with poor adherence.

  11. Effect of Zirconium Precursor on Performance of Pd/Ce0.45Zr0.45La0.1O1.95 Three-Way Catalyst%不同锆源对Pd/Ce0.45Zr0.45La0.1O1.95整体式三效催化剂性能的影响

    Institute of Scientific and Technical Information of China (English)

    陈山虎; 姚艳玲; 兰丽; 曹毅; 闫朝阳; 龚茂初; 陈耀强

    2012-01-01

    10.1016/S1872-2067(11)60445-2%  分别以ZrOCO3, ZrO(NO3)2和Zr(NO3)4为锆源采用双氧水氧化-共沉淀法合成了Ce0.45Zr0.45La0.1O1.95储氧材料,并用湿法浸渍法制备了Pd/Ce0.45Zr0.45La0.1O1.95三效催化剂,用X射线衍射、拉曼光谱、N2吸附、X射线光电子能谱、氢气程序升温还原和氧脉冲等技术对该催化剂进行了表征.结果表明,以 ZrOCO3和 ZrO(NO3)2为锆源时所制催化剂上只能检测到单一的CeO2-ZrO2立方相,而以Zr(NO3)4为锆源制备的催化剂经老化后却能检测到四方相;另外,在模拟汽车尾气组分和工作条件下考察了整体型Pd/Ce0.45Zr0.45La0.1O1.9催化剂的三效活性.结果表明,以ZrOCO3为前驱体制备的整体式Pd/Ce0.45Zr0.45La0.1O1.9催化剂对C3H8, CO和NO具有最佳的催化活性.认为ZrOCO3更有利于Zr4+和La3+进入CeO2晶格形成均一固溶体,从而提高催化剂的高温稳定性和氧化还原性能.

  12. Photocatalytic degradation of an azo textile dye (C.I. Reactive Red 195 (3BF)) in aqueous solution over copper cobaltite nanocomposite coated on glass by Doctor Blade method

    Science.gov (United States)

    Habibi, Mohammad Hossein; Rezvani, Zoya

    2015-08-01

    The degradation of C.I. Reactive Red 195 (3BF) in aqueous solution using copper cobaltite nanocomposite coated on glass by Doctor Blade method was studied. Structural, optical and morphological properties of nanocomposite coatings were characterized by X-ray powder diffractometry (XRD), diffuse reflectance spectroscopy (DRS) and field emission scanning electron microscopy (FESEM). The nanoparticles exhibit a particle size of 31 nm, showing a good nanoscale crystalline morphology. The photocatalytic activity of copper cobaltite nanocomposite coated on glass was studied by performing the photocatalytic degradation of 3BF at different irradiation time. The effect of irradiation time on the degradation of 3BF was studied and the results showed that more than 85% of the 3BF was degraded in 45 min of irradiation. The pseudo-first-order kinetic models were used and the rate constants were evaluated with pseudo first order rate constants of 4.10 × 10-2 min-1. The main advantage of the photocatalyst coated on glass overcomes the difficulties in separation and recycle of photocatalyst suspensions.

  13. Synthesis and properties of Mn1.05−yCo1.95−x−z−wNixMgyAlzFewO4 NTC ceramic by co-precipitation method

    International Nuclear Information System (INIS)

    Mn1.05−yCo1.95−x−z−wNixMgyAlzFewO4 negative temperature coefficient (NTC) material was synthesized by double precipitation reacting method. The synthesis condition was optimized. Fourier infrared (FI) spectrometer indicated that the precursor was consisted of oxalate and hydroxide. The powder was studied by X–ray diffraction (XRD) to obtain the optimum calcination temperature of 800 °C. The ceramics were mainly in the cubic spinel structure except for the minority of cubic cobalt oxide. Scanning electron microscope (SEM) image showed that the grain size decreased with the increase of Al2O3 content in the ceramic. While the room temperature resistivity ρ25 increased from 3027 Ω cm to 16,911 Ω cm with increasing Al2O3 content. The material constants B25/85 and activity energies were in the range of 3592–3977 K and 0.3112–0.3330 eV, respectively. Complex impedance analysis indicated that the grain boundary resistivity increased with increasing Al2O3 content, whereas, the grain resistance remains virtually unchanged. - Highlights: • Powder with composition near to starting component was synthesized by precipitation. • The grain size of the ceramic decreased with increasing Al2O3 content. • Only the grain boundary resistivity increased with Al2O3 concentration

  14. Influences of Gd2Ti2O7 sintering aid on the densification, ionic conductivity and thermal expansion of Gd0.1Ce0.9O1.95 electrolyte for solid oxide fuel cells

    Science.gov (United States)

    Guo, Ting; Zhang, Lei; Song, Xiao; Dong, Xiaolei; Shirolkar, Mandar M.; Wang, Meng; Li, Ming; Wang, Haiqian

    2014-09-01

    The effects of Gd2Ti2O7 (GT) as sintering aid on the densification, electrical properties and thermal expansion of Gd0.1Ce0.9O1.95 (GDC) are examined. Samples added with TiO2 sintering aid are also tested for comparison. It is found that by sintering at a moderate temperature of 1400 °C for 5 h, the relative density of the GT-added GDC can reach over 97% as the molar ratio of GT/GDC reaches 0.02 or higher. XRD analysis indicates that GT does not react with GDC, while TiO2 reacts with Gd in GDC to form GT. The ionic conductivities of the GT-added and the TiO2-added GDC are analyzed by AC impedance spectroscopy at 500-700 °C. The result shows that although the ionic conductivity of the GT-added GDC decreases as the GT/GDC molar ratio increases up to 0.05, it is still higher than that of 8YSZ and much higher than that of the GDC added with an equivalent amount of TiO2. It is also found that the thermal expansion coefficient of GDC decreases as the amount of GT increases. These results show that GT is an excellent sintering aid for GDC, and the optimal molar ratio of GT/GDC is 0.02 in terms of densification and ionic conductivity.

  15. La0.99Co0.4Ni0.6O3−δ–Ce0.8Gd0.2O1.95 as composite cathode for solid oxide fuel cells

    DEFF Research Database (Denmark)

    Hjalmarsson, Per; Mogensen, Mogens Bjerg

    2011-01-01

    We have studied a new composite SOFC cathode consisting of LaCo0.4Ni0.6O3−δ (LCN60) and Ce0.9Gd0.1O1.95 (CGO). The polarisation resistance (RP) at 750°C and OCV was measured to 0.05±0.01Ωcm2 and the activation energy was determined to be about 1eV. The impedance spectra were modelled with an EQC...... model consisting of a high frequency ZRQ circuit and a medium frequency Gerischer impedance, ZG. The resistance of ZG was found to decrease with approximately a factor of two as a consequence of infiltration of (La0.6Sr0.4)0.99CoO3 into the porous LCN60–CGO structure. RP of both infiltrated and non.......16–0.18Ωcm2 at 750°C....

  16. Sintering and grain growth kinetics in La0.85Sr0.15MnO3–Ce0.9Gd0.1O1.95 (LSM–CGO) porous composite

    DEFF Research Database (Denmark)

    Ni, De Wei; Andersen, Kjeld Bøhm; Esposito, Vincenzo

    2014-01-01

    The sintering kinetics in La0.85Sr0.15MnO3–Ce0.9Gd0.1O1.95 (LSM–CGO) porous composite was studied by applying a two-stage master sintering curve (MSC) approach and comparing with LSM and CGO single-phase materials. In the two-stage MSC, sintering mechanisms occurring at different stages were...... of the composite. Similarly, constrain effect was also observed in grain growth in the composite. Particularly, in the investigated temperature range (1100–1250°C), the determined grain boundary mobility of CGO in the LSM–CGO composite (10−18–10−16m3N−1s−1) is comparable with the single-phase CGO, while the grain...... boundary mobility of LSM in the composite (10−17–10−16m3N−1s−1) is around 1 order of magnitude smaller than the single-phase LSM....

  17. Dielectric, elastic, anelastic and conductivity behaviour of ferroelectromagnetic composites, Ni0.5Zn0.5Fe1.95O4– + Ba0.8Pb0.2TiO3

    Indian Academy of Sciences (India)

    N Ramamanohar Reddy; M Venkata Ramana; K Krishnaveni; K V Siva Kumar; V R K Murthy

    2007-08-01

    Ferroelectromagnetic composites with compositions, Ni0.5Zn0.5Fe1.95O4– + (1 – ) Ba0.8Pb0.2TiO3, in which varies as 0, 0.005, 0.010, 0.015, 0.020, 0.040, 0.060, 0.080 and 1 in mole %, were prepared by conventional ceramic double sintering process. The presence of two phases was confirmed by X-ray diffraction. The temperature variation of dielectric constant, ', dielectric loss, tan , d.c. conductivity, a.c. conductivity, elastic and anelastic behaviour of ferrite–ferroelectric composites were studied in the temperature range 30–350°C. The a.c. conductivity measurements on these composites in the frequency range 100 Hz–1 MHz at room temperature reveal that the conduction mechanism is due to small polaron hopping. The dielectric and elastic data were discussed in the light of phase transitions.

  18. Characterization of Ni{sub 5}3.5-Fe{sub 1}9.5-Ga{sub 2}7 Ni{sub 5}3.5 ferromagnetic shape memory alloy produced by powder metallurgy; Caracterizacion de la aleacion Ni{sub 5}3.5-Fe{sub 1}9.5-Ga{sub 2}7 con memoria de forma ferromagnetica producida por metalurgia de polvos

    Energy Technology Data Exchange (ETDEWEB)

    Olmos, L.; Alvarado-Hernandez, F.; Omar Jimenez, H.; Vergara-Hernandez, J.; Arroyo Albiter, M.; Ochoa-Gamboa, R. A.

    2015-07-01

    The main drawback of ferromagnetic shape memory alloys fabricated through casting methods are its brittleness. In order to overcome this disadvantage, powder metallurgy is an ideal technique for the consolidation of many engineering parts. This paper is focused on the study of the milling and sintering effects of metallic powders over the evolution of the crystalline phases responsibly for the shape memory effect of these materials. To achieve this objective, ferromagnetic shape memory alloy powders (Ni{sub 5}3.5-Fe{sub 1}9.5-Ga{sub 2}7) were prepared from a cast ingot by mechanical milling at two different times of 30 and 60 minutes. The evolution of the phases was investigated through high temperature X-ray diffraction (HTXRD), whereas sintering was analyzed with dilatometry tests. X-ray studies showed that four different phases can be present depending on the particle size and temperature at which the heat treatment was performed. Coarser powders showed a B2 structure along with a γ phase while the finer showed a L21 structure when treated below 1173 K. Furthermore, finer powders had a modulated M14 martensitic structure after sintering at temperatures above 1273 K. The sintering of powders was slow and a mass diffusion mechanism was not clearly observed. (Author)

  19. Caracterización de la aleación Ni53.5-Fe19.5-Ga27 con memoria de forma ferromagnética producida por metalurgia de polvos

    Directory of Open Access Journals (Sweden)

    Olmos, Luis

    2015-06-01

    Full Text Available The main drawback of ferromagnetic shape memory alloys fabricated through casting methods are its brittleness. In order to overcome this disadvantage, powder metallurgy is an ideal technique for the consolidation of many engineering parts. This paper is focused on the study of the milling and sintering effects of metallic powders over the evolution of the crystalline phases responsibly for the shape memory effect of these materials. To achieve this objective, ferromagnetic shape memory alloy powders (Ni53.5-Fe19.5-Ga27 were prepared from a cast ingot by mechanical milling at two different times of 30 and 60 minutes. The evolution of the phases was investigated through high temperature X-ray diffraction (HTXRD, whereas sintering was analyzed with dilatometry tests. X-ray studies showed that four different phases can be present depending on the particle size and temperature at which the heat treatment was performed. Coarser powders showed a B2 structure along with a γ phase while the finer showed a L21 structure when treated below 1173 K. Furthermore, finer powders had a modulated M14 martensitic structure after sintering at temperatures above 1273 K. The sintering of powders was slow and a mass diffusion mechanism was not clearly observed.La principal desventaja de las aleaciones con memoria de forma ferromagnéticas obtenidas por fundición es su fragilidad. Para superar esta desventaja la metalurgia de polvos es una técnica ideal para la consolidación de las piezas, por lo que este trabajo se orientó a estudiar el efecto generado por los procesos de molienda y sinterizado de polvos sobre la evolución de las fases cristalinas que le confieren la memoria de forma a estos materiales. Para ello se prepararon polvos de la aleación ferromagnética con memoria de forma Ni53.5-Fe19.5-Ga27 a partir de un lingote fundido mediante molienda mecánica, durante dos tiempos diferentes de molienda de 30 y 60 minutos. La evolución de las fases fue

  20. BDML Metadata: 195 [SSBD[Archive

    Lifescience Database Archive (English)

    Full Text Available 94-b85a-4272-87e4-e2204b65ef58 0.105 x 0.105 x 0.5 (micrometer), 40 (second) http://ssbd.qbic.riken.jp/data/...source/Ce_KK_P002/RNAi_T08A11.2_040907_02.zip http://ssbd.qbic.riken.jp/data/bdml.../Ce_KK_P002/RNAi_T08A11.2_040907_02.bdml0.18.xml http://ssbd.qbic.riken.jp/data/pdpml/Ce_KK_P002.pdpml0.06.x...ml http://ssbd.qbic.riken.jp/search/e9861694-b85a-4272-87e4-e2204b65ef58/ http://ssbd.qbic.riken.jp/omero/webclient/?show=dataset-98 ...

  1. 21 CFR 558.195 - Decoquinate.

    Science.gov (United States)

    2010-04-01

    ...) of this section; as an aid in the prevention of necrotic enteritis caused or complicated by... treatment of bacterial enteritis caused by Escherichia coli; and for treatment of bacterial pneumonia caused...) of this section; for treatment of bacterial enteritis caused by E. coli; and for treatment...

  2. QTL Information Table: 195 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available antitative Trait Loci for Component Physiological Traits Determining Salt Tolerance in Rice. Plant Physiology 125, 406-422. http://www.plantphysiol.org/cgi/content/abstract/125/1/406 ...

  3. 46 CFR 195.11-5 - Scope.

    Science.gov (United States)

    2010-10-01

    ... structures which may be carried aboard a vessel for a limited period of time and which are not permanently... carried aboard a vessel for a limited period of time and which are not permanently attached to the vessel. The use, arrangement, and handling of such portable structures shall be approved by the Officer...

  4. 32 CFR 195.6 - Assurances required.

    Science.gov (United States)

    2010-07-01

    ... institutions. (1) In the case of Federal financial assistance to an institution of higher education, the... real property proposes to mortgage or otherwise encumber the real property as security for financing... if necessary to accomplish such financing, and upon such conditions as he deems appropriate,...

  5. 49 CFR 195.2 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... tanks, between a pressure pump station and a block valve, or between adjacent block valves. Low-stress pipeline means a hazardous liquid pipeline that is operated in its entirety at a stress level of 20 percent... residential or commercial area such as a subdivision, a business or shopping center, or community...

  6. 32 CFR 195.10 - Hearings.

    Science.gov (United States)

    2010-07-01

    ...) and consent to the making of a decision on the basis of such information as is available. (b) Time and... the substance thereof is stipulated for the record. All decisions shall be based upon the hearing record and written findings shall be made. (f) Consolidated or joint hearings. In cases in which the...

  7. Electronic conductivity of Ce(0.9)Gd(0.1)O(1.95-δ) and Ce(0.8)Pr(0.2)O(2-δ): Hebb-Wagner polarisation in the case of redox active dopants and interference

    DEFF Research Database (Denmark)

    Chatzichristodoulou, Christodoulos; Hendriksen, Peter Vang

    2011-01-01

    The electronic conductivity of Ce(0.9)Gd(0.1)O(1.95-δ) and Ce(0.8)Pr(0.2)O(2-δ) under suppressed ionic flow was measured as a function of pO(2) in the range from 10(3) atm to 10(-17) atm for temperatures between 600 °C and 900 °C by means of Hebb-Wagner polarisation. The steady state I-V curve...... of Ce(0.9)Gd(0.1)O(1.95-δ) could be well described by the standard Hebb-Wagner equation [M. H. Hebb, J. Chem. Phys., 1952, 20, 185; C. Wagner, Z. Elektrochem., 1956, 60, 4], yielding expressions for the n- and p-type conductivity as a function of pO(2). On the other hand, significant deviation...... of the steady state I-V curve from the standard Hebb-Wagner equation was observed for the case of Ce(0.8)Pr(0.2)O(2-δ). It is shown that the I-V curve can be successfully reproduced when the presence of the redox active dopant, Pr(3+)/Pr(4+), is taken into account, whereas even better agreement can be reached...

  8. Enhancement of NOx removal performance for (La0.85Sr0.15)0.99MnO3/Ce0.9Gd0.1O1.95 electrochemical cells by NOx storage/reduction adsorption layers

    DEFF Research Database (Denmark)

    Shao, Jing; Kammer Hansen, Kent

    2013-01-01

    This study investigated the effect of adding a NOx adsorption layer to the cathode of an electrochemical cell on the removal of NOx from gaseous mixtures. The cathode was a composite of (La0.85Sr0.15)0.99MnO3 (LSM15) and Ce0.9Gd0.1O1.95 (CGO10). Two different kinds of adsorption layers, K–Pt–Al2O...

  9. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  10. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  11. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  12. C-ring cleavage of isoflavone daidzein by a newly-isolated facultative Enterococcus hirae AUH-HMl95 from Crossoptilon mantchuricum feces%兼性肠球菌Enterococcus hirae AUH-HM195对黄豆苷原的开环转化

    Institute of Scientific and Technical Information of China (English)

    于飞; 王世英; 李佳; 张琪; 李朝东; 王秀伶

    2009-01-01

    [目的]从褐马鸡粪样中分离对大豆异黄酮黄豆苷原具有转化作用的功能微生物菌株.[方法]在厌氧工作站内对褐马鸡新鲜粪样进行梯度稀释后涂板,从板上挑取单菌落与底物黄豆苷原厌氧混合培养,用高效液相色谱检测底物被转化情况.[结果]分离出一株对黄豆苷原具开环转化作用的革兰氏阳性兼性好氧菌株AUH-HM195(EU919863),经BLAST比对,该菌株的16S rDNA基因全序与肠球菌属菌株Enterococcus hirae (DSM20160)的相似性为100%.根据保留时间、代谢产物最大紫外吸图谱以及核磁共振氢谱和碳谱等分析结果,将菌株Enterococcus hirae AUH-HM195降解黄豆苷原的代谢产物确定为去氧甲基安哥拉紫檀素.纯化后的代谢产物在手性柱上出现两个物质峰,其对映体过量率为66.9%.[结论]细菌菌株Enterococcus hirae AUH-HM195为国内外首次报道的对黄豆苷原具有开环转化作用的肠球菌属菌株,同时也是第一个报道的对大豆异黄酮具有转化作用的兼性微生物菌株.

  13. Phase-inversion tape-casting preparation and significant performance enhancement of Ce0.9Gd0.1O1.95- La0.6Sr0.4Co0.2Fe0.8O3-δ dual-phase asymmetric membrane for oxygen separation

    DEFF Research Database (Denmark)

    Huang, Hua; Cheng, Shiyang; Gao, Jianfeng;

    2014-01-01

    The dual-phase Ce0.9Gd0.1O1.95–La0.6Sr0.4Co0.2Fe0.8O3−δ asymmetric membrane was prepared via a phase-inversion tape-casting method. The membrane consisted of a thicker porous support layer and a thinner dense layer. When the dense side of the membrane was coated with a La0.6Sr0.4CoO3−δ catalytic...... activation layer, the oxygen permeation flux was markedly increased by a factor of 4.1–5.6, reaching 0.45 mL cm−2 min−1 at 900 °C. The flux increase can be attributed to enhanced surface oxygen exhange kinetics....

  14. High-Performance Microchanneled Asymmetric Gd0.1Ce0.9O1.95-La0.6Sr0.4FeO3-δ-Based Membranes for Oxygen Separation

    DEFF Research Database (Denmark)

    Cheng, Shiyang; Huang, Hua; Ovtar, Simona;

    2016-01-01

    A microchanneled asymmetric dual phase composite membrane of 70 vol % Gd0.1Ce0.9O1.95-delta-30 vol % La0.6Sr0.4FeO3-delta (CGO-LSF) was fabricated by a "one step" phase-inversion tape casting. The sample consists of a thin dense membrane (100 mu m) and a porous substrate including "finger...... surface. An increase of the 50 150 oxygen flux of-4.49 (STP) mL cm(-2) min(-1) at 900 degrees C was observed when catalyst is added for the air/He-case. Mass transfer polarization through the finger-like support was confirmed to be negligible, which benefits the overall performance. A stable flux of 7...

  15. Magnetoelectric properties of lead-free Ni0.93Co0.02Mn0.05Fe1.95O4–Na0.5Bi0.5TiO3 multiferroic composites synthesized by spark plasma sintering

    International Nuclear Information System (INIS)

    Lead-free multiferroic ceramic composites of x Ni0.93Co0.02Mn0.05Fe1.95O4−(1–x) Na0.5Bi0.5TiO3 (x NCMF−(1–x) NBT, where x=0.1, 0.2, 0.3, 0.4 and 0.5 mol fraction) were synthesized by spark plasma sintering (SPS) in conjunction with high-energy ball milling. The phases, dielectric, piezoelectric, ferroelectric, magnetic and magnetoelectric properties of the composites were analyzed. The composites were composed of a mixture of spinel and perovskite phases. All the composite samples exhibited both apparent ferroelectric and ferromagnetic characteristics as well as considerable magnetoelectric (ME) effects. The maximum value of the ME voltage coefficient of the composites was quite high, being up to ~670 mV cm−1 Oe−1 for the 0.5 NCMF−0.5 NBT composite. Overall, the synthesized composites were promising in terms of electrical, magnetic and magnetoelectric properties, indicating that the SPS is a promising method of fabricating ME composite materials. - Highlights: • Ni0.93Co0.02Mn0.05Fe1.95O4–Na0.5Bi0.5TiO3 composites are synthesized by SPS. • The composites exhibit apparent ferromagnetic and ferroelectric characteristics. • There is quite a high magnetoelectric coefficient for the 0.5 NCMF−0.5 NBT composite. • SPS is a promising method of synthesizing multiferroic ceramic composites

  16. Preparation and electrical properties of Mn{sub 1.05−y}Co{sub 1.95−x−z−w}Ni{sub x}Mg{sub y}Al{sub z}Fe{sub w}O{sub 4} NTC ceramic derived from microemulsion method

    Energy Technology Data Exchange (ETDEWEB)

    Xia, Junbo [Key Laboratory of Functional Materials and Devices under Special Environments, CAS, Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics and Chemistry, CAS, Urumqi 830011 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Zhao, Qing, E-mail: zhaoq@ms.xjb.ac.cn [Key Laboratory of Functional Materials and Devices under Special Environments, CAS, Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics and Chemistry, CAS, Urumqi 830011 (China); Gao, Bo [Key Laboratory of Functional Materials and Devices under Special Environments, CAS, Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics and Chemistry, CAS, Urumqi 830011 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Chang, Aimin, E-mail: changam@ms.xjb.ac.cn [Key Laboratory of Functional Materials and Devices under Special Environments, CAS, Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics and Chemistry, CAS, Urumqi 830011 (China); Zhang, Bo; Ma, Renjun [Key Laboratory of Functional Materials and Devices under Special Environments, CAS, Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics and Chemistry, CAS, Urumqi 830011 (China); University of Chinese Academy of Sciences, Beijing 100049 (China)

    2014-04-05

    Highlights: • The NTC thermister nano-powders Mn{sub 1.05−y}Co{sub 1.95−x−z−w}Ni{sub x}Mg{sub y}Al{sub z}Fe{sub w}O{sub 4} were prepared by microemulsion method. • The metal ions were subsided after twice sediment reaction. • The specimens show good electrical properties by doping some nontransition metals. -- Abstract: The NTC thermistor nano-powders of Mn{sub 1.05−y}Co{sub 1.95−x−z−w}Ni{sub x}Mg{sub y}Al{sub z}Fe{sub w}O{sub 4} were prepared by microemulsion method. Scanning electron microscope (SEM) image showed that the particles were well distributed. The mean particle-size was 72 nm. The structure of the precursor was investigated with Fourier infrared spectrometer (FI). The compositions of the powder and the as-sintered ceramic were evaluated by Energy Disperse Spectroscopy (EDS). X-ray diffraction (XRD) result indicated that the sintered samples were in the spinel structure. The room temperature resistivity ρ{sub 25}, material constant B{sub 25/85} and activation energies of the NTC thermistor are in the range of 1173–19,059 Ω cm, 3169–3771 k, 0.2672–0.3136 eV. The room temperature resistivity and B{sub 25/85} constant were found to increase with Al{sub 2}O{sub 3} content. The Mn{sub 0.9}Co{sub 1.2}Ni{sub 0.21}Mg{sub 0.15}Al{sub 0.09}Fe{sub 0.45}(A2) and Mn{sub 0.9}Co{sub 1.2}Ni{sub 0.27}Mg{sub 0.15}Al{sub 0.03}Fe{sub 0.45}(A3) specimens both showed a 200 °C resistance drift (ΔR/R) within 10% after aging at 910 °C for 600 h.

  17. Synthesis and properties of Mn{sub 1.05−y}Co{sub 1.95−x−z−w}Ni{sub x}Mg{sub y}Al{sub z}Fe{sub w}O{sub 4} NTC ceramic by co-precipitation method

    Energy Technology Data Exchange (ETDEWEB)

    Xia, Junbo [Key Laboratory of Functional Materials and Devices Under Special Environments, Chinese Academy of Sciences (CAS), Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics and Chemistry, CAS, Urumqi 830011 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Zhao, Qing, E-mail: zhaoq@ms.xjb.ac.cn [Key Laboratory of Functional Materials and Devices Under Special Environments, Chinese Academy of Sciences (CAS), Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics and Chemistry, CAS, Urumqi 830011 (China); Chang, Aimin, E-mail: changam@ms.xjb.ac.cn [Key Laboratory of Functional Materials and Devices Under Special Environments, Chinese Academy of Sciences (CAS), Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics and Chemistry, CAS, Urumqi 830011 (China); Zhang, Bo [Key Laboratory of Functional Materials and Devices Under Special Environments, Chinese Academy of Sciences (CAS), Xinjiang Key Laboratory of Electronic Information Materials and Devices, Xinjiang Technical Institute of Physics and Chemistry, CAS, Urumqi 830011 (China)

    2015-10-15

    Mn{sub 1.05−y}Co{sub 1.95−x−z−w}Ni{sub x}Mg{sub y}Al{sub z}Fe{sub w}O{sub 4} negative temperature coefficient (NTC) material was synthesized by double precipitation reacting method. The synthesis condition was optimized. Fourier infrared (FI) spectrometer indicated that the precursor was consisted of oxalate and hydroxide. The powder was studied by X–ray diffraction (XRD) to obtain the optimum calcination temperature of 800 °C. The ceramics were mainly in the cubic spinel structure except for the minority of cubic cobalt oxide. Scanning electron microscope (SEM) image showed that the grain size decreased with the increase of Al{sub 2}O{sub 3} content in the ceramic. While the room temperature resistivity ρ{sub 25} increased from 3027 Ω cm to 16,911 Ω cm with increasing Al{sub 2}O{sub 3} content. The material constants B{sub 25/85} and activity energies were in the range of 3592–3977 K and 0.3112–0.3330 eV, respectively. Complex impedance analysis indicated that the grain boundary resistivity increased with increasing Al{sub 2}O{sub 3} content, whereas, the grain resistance remains virtually unchanged. - Highlights: • Powder with composition near to starting component was synthesized by precipitation. • The grain size of the ceramic decreased with increasing Al{sub 2}O{sub 3} content. • Only the grain boundary resistivity increased with Al{sub 2}O{sub 3} concentration.

  18. 24 CFR 990.195 - Calculation of formula income.

    Science.gov (United States)

    2010-04-01

    ... communications with the respective PHAs. (e) Inapplicability of 24 CFR 85.25. Formula income is not subject to the provisions regarding program income in 24 CFR 85.25. ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Calculation of formula income....

  19. 49 CFR 195.59 - Abandonment or deactivation of facilities.

    Science.gov (United States)

    2010-10-01

    ... operator of that facility must file a report upon abandonment of that facility. (a) The preferred method to... System (NPMS) in accordance with the NPMS “Standards for Pipeline and Liquefied Natural Gas Operator... the NPMS-required attributes, operators must submit the date of abandonment, diameter, method...

  20. 40 CFR 60.195 - Test methods and procedures.

    Science.gov (United States)

    2010-07-01

    ..., dscm/hr (dscf/hr). Pe=aluminum equivalent for anode production rate, Mg/hr (ton/hr). K=conversion... fluorides concentration (Cs) and volumetric flow rate (Qsd) of the effluent gas. The sampling time and... emission standards in §§ 60.192 and 60.193 as follows: (1) The emission rate (Ep) of total fluorides...

  1. 1935 15' Quad #195 Aerial Photo Mosaic Index - AZ

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Aerial Photo Reference Mosaics contain aerial photographs that are retrievable on a frame by frame basis. The inventory contains imagery from various sources that...

  2. 49 CFR 195.106 - Internal design pressure.

    Science.gov (United States)

    2010-10-01

    ... 1.00 Electric resistance welded 1.00 Furnace lap welded 0.80 Furnace butt welded 0.60 ASTM A106 Seamless 1.00 ASTM A 333/A 333M Seamless 1.00 Welded 1.00 ASTM A381 Double submerged arc welded 1.00 ASTM... 1.00 API 5L Seamless 1.00 Electric resistance welded 1.00 Electric flash welded 1.00 Submerged...

  3. Dicty_cDB: SSG195 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available n, complete cds. 58 2e-04 1 AI067610 |AI067610.1 EST209292 Schistosoma mansoni, Phil LoVerde/Joe Merrick Sch...9616 Schistosoma mansoni female, Phil LoVerde/Joe Merrick Schistosoma mansoni cDNA clone SMFAA90 5' end simi...stosoma mansoni female, Phil LoVerde/Joe Merrick Schistosoma mansoni cDNA clone SMFAV16 5' end, mRNA sequenc...e. 34 0.003 3 AI977044 |AI977044.1 EST271638 Schistosoma mansoni male, Phil LoVerde/Joe Merrick Schistosoma ...mansoni cDNA clone SMMAE72 5' end, mRNA sequence. 34 0.003 3 AI977557 |AI977557.1 EST272151 Schistosoma mans

  4. Dicty_cDB: VHM195 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available sequence from clone ... 63 2e-08 BC066531_1( BC066531 |pid:none) Danio rerio scinderin like b, mRNA... 63 2...e-08 BC155581_1( BC155581 |pid:none) Danio rerio scinderin like a, mRNA... 62 4e-08 BC125898_1( BC125898 |pid:none) Danio rerio scind...erin like a, mRNA... 62 4e-08 AF175294_1( AF175294 |pid:

  5. 49 CFR 195.6 - Unusually Sensitive Areas (USAs).

    Science.gov (United States)

    2010-10-01

    ... imperiled species or ecological community (habitat) means an animal or plant species or an ecological...,000). These species and ecological communities are extremely vulnerable to extinction due to some... community means an interacting assemblage of plants and animals that recur under similar...

  6. Chemical compatibility, redox behavior, and electrochemical performance of Nd1−xSrxCoO3−δ cathodes based on Ce1.9Gd0.1O1.95 for intermediate-temperature solid oxide fuel cells

    International Nuclear Information System (INIS)

    Highlights: ► Nd1−xSrxCoO3−δ (x = 0.3, 0.4, 0.5, 0.6, and 0.7) are synthesized by glycine nitrate method and investigated the effect of Sr substitution for Nd. ► Electrical properties of the samples are identified by a four-terminal DC arrangement in air. ► Symmetrical half cells are measured by impedance spectroscopy at 500, 550, 600, 650, and 700 °C in air under an open-circuit condition. ► Electrochemical performances of Nd1−xSrxCoO3−δ cathodes are investigated using an anode supported cell based on GDC electrolyte for application to IT-SOFCs. - Abstract: The effect of Sr substitution for Nd on Nd1−xSrxCoO3−δ (NSC) (x = 0.3, 0.4, 0.5, 0.6, and 0.7) is investigated to evaluate NSC as a cathode material based on Gd0.1Ce0.9O1.95 (GDC) electrolyte for intermediate-temperature solid oxide fuel cells (IT-SOFCs). The NSC powders are prepared by the glycine nitrate method. At a given temperature, the electrical conductivity increases with increasing Sr content up to x = 0.5 and then decreases for x > 0.5. The redox behavior of NSC (x = 0.3, 0.5, and 0.7) cathodes is studied by the coulometric titration at 700 °C. In order to investigate the area specific resistances of NSC–GDC cathodes, symmetrical half cells (cathode/electrolyte/cathode) are measured using impedance spectroscopy at various temperatures in air under open circuit voltage (OCV) condition. The electrochemical performance of NSC–GDC cathodes is measured using an NSC–GDC/GDC/Ni-GDC anode supported cell. The maximum power density of NSC–GDC cathodes increases with increasing strontium content up to x = 0.5 and then decreases at 700 °C. In terms of electrical conductivity and electrochemical performance, Nd1−xSrxCoO3−δ (x = 0.5) is more suitable as a cathode material based on GDC electrolyte in IT-SOFC applications.

  7. KN195L12: WHOI cruise 195 leg 12 aboard the R/V Knorr from 2009-07-24 - 2009-08-09 (NODC Accession 0081792)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Post-cruise download of raw data from shipboard computer(s) as furnished by the Woods Hole Oceanographic Institution Shipboard Scientific Support Group and archived...

  8. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE,CERN

    OpenAIRE

    Rothe, Sebastian

    2012-01-01

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spec...

  9. НЕЙРОПРОТЕКТОРНОЕ ДЕЙСТВИЕ НОВОГО ПРОИЗВОДНОГО ГАМК-РГПУ-195 ПРИ ИШЕМИИ ГОЛОВНОГО МОЗГА

    OpenAIRE

    Мазина, Н.; Волотова, Е.; Куркин, Д.

    2013-01-01

    Целью проведённого исследования явилось изучение нейропротекторного действия нового производного ГАМК–соединения под лабораторным шифром РГПУ-195 в различных дозах на модели ишемии головного мозга, вызванной необратимой одномоментной окклюзией общих сонных артерий. Методы: исследование выполнено на крысах самцах. Нарушение мозгового кровообращения моделировалось путём необратимой билатеральной окклюзии общих сонных артерий, за 30 минут до которой вводилось исследуемое соединение – РГПУ-195 в ...

  10. SU-E-T-195: Gantry Angle Dependency of MLC Leaf Position Error

    Energy Technology Data Exchange (ETDEWEB)

    Ju, S; Hong, C; Kim, M; Chung, K; Kim, J; Han, Y; Ahn, S; Chung, S; Shin, E; Shin, J; Kim, H; Kim, D; Choi, D [Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2014-06-01

    Purpose: The aim of this study was to investigate the gantry angle dependency of the multileaf collimator (MLC) leaf position error. Methods: An automatic MLC quality assurance system (AutoMLCQA) was developed to evaluate the gantry angle dependency of the MLC leaf position error using an electronic portal imaging device (EPID). To eliminate the EPID position error due to gantry rotation, we designed a reference maker (RM) that could be inserted into the wedge mount. After setting up the EPID, a reference image was taken of the RM using an open field. Next, an EPID-based picket-fence test (PFT) was performed without the RM. These procedures were repeated at every 45° intervals of the gantry angle. A total of eight reference images and PFT image sets were analyzed using in-house software. The average MLC leaf position error was calculated at five pickets (-10, -5, 0, 5, and 10 cm) in accordance with general PFT guidelines using in-house software. This test was carried out for four linear accelerators. Results: The average MLC leaf position errors were within the set criterion of <1 mm (actual errors ranged from -0.7 to 0.8 mm) for all gantry angles, but significant gantry angle dependency was observed in all machines. The error was smaller at a gantry angle of 0° but increased toward the positive direction with gantry angle increments in the clockwise direction. The error reached a maximum value at a gantry angle of 90° and then gradually decreased until 180°. In the counter-clockwise rotation of the gantry, the same pattern of error was observed but the error increased in the negative direction. Conclusion: The AutoMLCQA system was useful to evaluate the MLC leaf position error for various gantry angles without the EPID position error. The Gantry angle dependency should be considered during MLC leaf position error analysis.

  11. Formulation studies and grout development for fixation of variable phosphate/sulfate waste, Milestone 195

    International Nuclear Information System (INIS)

    The objective of this work was to develop a range of cement-based blended dry solids which, when mixed with variable phosphate/sulfate waste (PSW), produce grouts that are processible in the Rockwell Hanford Operations (RHO) Transportable Grout Facility (TGF). The selected formula(s) will also utilize commerically available materials requiring no custom processing and meet all criteria as identified and quantified by RHO, not only for grouts made with the reference formula, but also for those grouts made with reasonable deviations from the reference formula expected during routine TGF operation. This report presents experimental data for processibility and solid performance as well as graphical representations of the data. Based upon the results of the preliminary study, several grout formulas were found that produced acceptable grouts. One such formula, composed of Type III Portland cement (50 wt%), class F fly ash (28 wt%), Attapulgite-150 clay (14 wt%), and Indian red pottery clay (IRPC) (8 wt%), produced acceptable grouts with several of the waste concentrations studied. When mixed with 100% sulfate waste, this blend produced acceptable grouts at mix ratios of 8, 8.5, and 9 lb/gal. This particular blend also produced acceptable grouts at waste concentrations of 25/75 and 75/25 PSW. 12 refs., 27 figs., 13 tabs

  12. 41 CFR 102-85.195 - Does GSA provide special services?

    Science.gov (United States)

    2010-07-01

    ... Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 85-PRICING POLICY FOR... bill amount. The bill amount for separable special services is either based on a previously agreed upon... special services on a cost-reimbursable basis: (a) In GSA-controlled space, GSA may provide for...

  13. 40 CFR 417.195 - Standards of performance for new sources.

    Science.gov (United States)

    2010-07-01

    ...) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING POINT SOURCE CATEGORY Manufacture of... COD 2.70 1.35 TSS 0.20 .10 Surfactants 0.40 .20 Oil and grease 0.04 .02 pH (1) (1) English units... Oil and grease 0.04 .02 pH (1) (1) 1 Within the range 6.0 to 9.0....

  14. Yeast Interacting Proteins Database: YLR208W, YDL195W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the format...clear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important

  15. Measurements of Discrete Symmetries in the Neutral Kaon System with the CPLEAR (PS195) Experiment

    CERN Document Server

    Ruf, Thomas

    2015-01-01

    The antiproton storage ring LEAR offered unique opportunities to study the symmetries which exist between matter and antimatter. At variance with other approaches at this facility, CPLEAR was an experiment devoted to the study of T, CPT and CP symmetries in the neutral kaon system. It measured with high precision the time evolution of initially strangeness-tagged $K^0$ and $\\bar{K}^0$ states to determine the size of violations with respect to these symmetries in the context of a systematic study. In parallel, limits concerning quantum-mechanical predictions (EPR paradox, coherence of the wave function) or the equivalence principle of general relativity have been obtained. This article will first discuss briefly the unique low energy antiproton storage ring LEAR followed by a description of the CPLEAR experiment, including the basic formalism necessary to understand the time evolution of a neutral kaon state and the main results related to measurements of discrete symmetries in the neutral kaon system. An exce...

  16. 14 CFR Sec. 19-5 - Air transport traffic and capacity elements.

    Science.gov (United States)

    2010-01-01

    ... is reported on Form 41 Schedule T-100 in column C-1, as follows: Col. All carrier groups and entities... T-100 in Column B-7, as follows: Col. All carrier groups and entities B-7 130 Revenue passengers...-100 in column B-4, as follows. Col. All carrier groups and entities B-4 310 Available seats,...

  17. 42 CFR 416.195 - Determination of membership in new classes of new technology IOLs.

    Science.gov (United States)

    2010-10-01

    ... following criteria to determine whether an IOL qualifies for a payment adjustment as a member of a new class..., class-defining characteristic associated with improved clinical outcomes with members of an active or..., improved outcomes in comparison with use of currently available IOLs. Superior outcomes include:...

  18. 49 CFR 195.428 - Overpressure safety devices and overfill protection systems.

    Science.gov (United States)

    2010-10-01

    ... months, but at least twice each calendar year, inspect and test each pressure limiting device, relief... breakout tanks containing highly volatile liquids, each operator shall test each valve at intervals not... API Standard 2510 after October 2, 2000, must have an overfill protection system installed...

  19. 36 CFR 223.195 - Procedures for identifying and marking unprocessed timber.

    Science.gov (United States)

    2010-07-01

    ... procedures required herein. (f) Waiver of branding requirements. Regional Foresters may waive the branding... individual timber sale basis, all or a portion of the branding requirements pursuant to paragraph (c)(2) of...) Regions 5 and 6. On an individual timber sale basis, the branding requirement pursuant to paragraph...

  20. 49 CFR Appendix C to Part 195 - Guidance for Implementation of an Integrity Management Program

    Science.gov (United States)

    2010-10-01

    ... in its required schedule for evaluation and remediation. I. Identifying a high consequence area and... product the pipeline is transporting (refined products, crude oils, highly volatile liquids, etc.) Highly... access for spill response or any other purpose). (17) Physical support of the segment such as by a...

  1. "... moi korabl?"l K 195-letiju V.I. Dalja / Gennadi Kuznetsov

    Index Scriptorium Estoniae

    Kuznetsov, Gennadi

    1996-01-01

    Vene keeleteadlane Vladimir Dal ja tema suhted Eestiga. Ilmunud ka kogumikus: Kuznetsov, Gennadi. I tolko dushi ihh, kak svetshi : otsherki o russkoi Pribaltike. Tallinn : Tarbeinfo - Russkii Telegraf, 2003, lk. 86-101

  2. 40 CFR 80.195 - What are the gasoline sulfur standards for refiners and importers?

    Science.gov (United States)

    2010-07-01

    ... standards for any refinery(ies) owned by the joint venture that are not included in one partner's corporate... the refiner of any refinery facilities owned by the parent company's wholly-owned subsidiaries for... company and any refineries owned by the parent company's wholly-owned subsidiaries; or (iii) A...

  3. Small angle neutron scattering analysis programs on the Rutherford Laboratory IBM 360/195 computers

    International Nuclear Information System (INIS)

    The implementation and operation of the suite of programs used for the analysis of small angle neutron scattering data originally written at the ILL (Grenoble) is described. The programs make use of a circulating data file which is also described and may be used by a variety of data analysis programs. (author)

  4. Application of Diesel-Nitrogen Atomization Technology in Well Y195-X67%柴油-氮气雾化钻井技术在 Y195-X67井应用

    Institute of Scientific and Technical Information of China (English)

    谢从辉; 刘林红; 宋瑞宏

    2016-01-01

    常规氮气钻井技术主要用于气井储层钻进,以防止由于空气钻井带来的高风险,但不适用于浅层气藏。为了提高葡萄花油层勘探开发效果,保护储层,防止由于泥浆钻井带来的储层污染,大庆油田开展了柴油-氮气雾化工艺技术研究。该技术利用雾化钻井液携岩效率高,柴油可有效稀释原油等技术优势。通过自主研制小型旋转防喷器、专用安全丢手工具等,实现了储层的安全、高效施工,减少了后期开发成本。相比邻井提高了产量,达到了很好的应用效果。%The conventional nitrogen drilling technology is mainly used in gas reservoir,for preven-ting the high risk brought air drilling.In order to improve the development effect of Putaohua for-mation,protect the reservoir and prevent the reservoir pollution caused by mud,Daqing oilfield carried out the technology of the diesel-nitrogen atomization,using the technical advantages of the atomized drilling fluid’s carrying rock better and diesel oil can dilute crude oil effectively,through developing a small RBOP and a special safety releasing tool independently,which built safely and efficiently,reduced the cost,increased the output compared to the adjacent wells,and achieved a great effect.

  5. An Evaluation of School-Based Support Groups for Children of Divorced or Separated Parents. No. 195.

    Science.gov (United States)

    Rosenstein-Manner, Merle

    In the 1989-90 school year, POINT (Parents and Organizations in North Toronto) and Social Work Services, Toronto (Ontario) Board of Education, conducted six peer-support groups for those elementary school children (grades 5-8) in North Toronto whose parents were divorced or separated. Topics covered in 10 weekly 1-hour sessions included parental…

  6. 性早熟诊疗指南(试行)[卫办医政发(195)号

    Institute of Scientific and Technical Information of China (English)

    中华人民共和国卫生部

    2011-01-01

    @@ 一、定义 性早熟(precocious puberty)是指男童在9岁前,女童在8岁前呈现第二性征.按发病机理和临床表现分为中枢性(促性腺激素释放激素依赖性)性早熟和外周性(非促性腺激素释放激素依赖性)性早熟,以往分别称真性性早熟和假性性早熟.

  7. The Effect of Sr Modification and Holding Time on Si Morphology and Mechanical Properties of ETIAL 195 Alloy

    Directory of Open Access Journals (Sweden)

    Muhammet Uludağ

    2015-12-01

    Full Text Available Hypereutectic Al-Si alloys are typically used in applications where wear resistance is required. The primary factor that determines the wear properties is the morphology of Si in these types of alloys. Pouring temperature is one of the ways to control Si size and shape. On the other hand, bifilm defects that may be present in the liquid can significantly alter the morphology of Si acting as a heterogeneous nucleant. Therefore in this work, castings were made at 800 °C with varying holding time and the effects of bifilm on the Si morphology was studied. Bifilm content was measured by Reduced Pressure Test and image analysis was used to characterize Si morphology. In addition, tensile tests were carried out to correlate Si morphology with mechanical properties.

  8. Mesoporous high surface area Ce0.9Gd0.1O1.95 synthesized by spray drying

    DEFF Research Database (Denmark)

    Lundberg, Mats; Wang, Hsiang-Jen; Blennow Tullmar, Peter;

    2011-01-01

    Mesoporous gadolinium doped cerium dioxide with high surface area was produced by spray drying using Pluronic 123 as surfactant. The powder, when calcined at 400 °C, had a BET surface area of 136 m2 g−1 and was polycrystalline as confirmed by XRD and TEM. XEDS confirmed Ce, Gd and O, as the only...

  9. Compound list: simvastatin [Open TG-GATEs

    Lifescience Database Archive (English)

    Full Text Available simvastatin SST 00117 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human/in_vitro/simv...astatin.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vitro/simv...astatin.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vivo/Liver/Single/simv...archive/open-tggates/LATEST/Rat/in_vivo/Liver/Repeat/simvastatin.Rat.in_vivo.Liver.Repeat.zip ...

  10. Pumping Iron in Australia: Prevalence, Trends and Sociodemographic Correlates of Muscle Strengthening Activity Participation from a National Sample of 195,926 Adults

    OpenAIRE

    Bennie, Jason A; Zeljko Pedisic; Jannique G Z van Uffelen; Charity, Melanie J.; Harvey, Jack T; Banting, Lauren K; Ineke Vergeer; Biddle, Stuart J.H.; Eime, Rochelle M

    2016-01-01

    Objective The current Australian Physical Activity Guidelines recommend that adults engage in regular muscle-strengthening activity (e.g. strength or resistance training). However, public health surveillance studies describing the patterns and trends of population-level muscle-strengthening activity participation are sparse. The aim of this study is to examine the prevalence, trends and sociodemographic correlates of muscle-strengthening activity participation in a national-representative sam...

  11. 中国家电博览会(AWE),德国凯驰195m3展台如约而至

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    据悉,中国家电及消费电子博览会,由中国家用电器协会主办,即原中国家电博览会,历经十四届臻华,规模屡创新高。2016年AWE正式更名为“中国家电及消费电子博览会”,展示包括传统家电、视听、数码、通讯、智能家居等消费电子和智能应用产品,展会影响力享誉全球,是全球三大家电及消费电子展之一。

  12. Comment on: Tarasov, A. & Titov, K., 2013, On the use of the Cole-Cole equations in spectral induced polarization, Geophys. J. Int., 195, 352-356

    Science.gov (United States)

    Macnae, James

    2015-07-01

    A recent paper by Tarasov and Titov suggested that the Cole-Cole conductivity models should be preferred to the Pelton resistivity model in fitting induced polarization responses. Each model has four parameters: resistivity ρ (or its inverse conductivity σ), chargeability m, time parameter τ and frequency dependence c. Tarasov and Titov showed that in fitting experimental data, 3 of the parameters directly correspond across the two formulations, but that there is a difference between the Pelton and Cole-Cole model in that parameter τ is only the same at low frequency, but is an entangled function with m and c at high frequencies in the Pelton formulation. This claim of inconsistent τ was based on using the Pelton complex resistivity formulation and the Cole-Cole complex conductivity equation to analyse complex conductivity data as a function of frequency. However, if Pelton and Cole-Cole models are used to fit complex resistivity, rather than fitting conductivity, then it is the Cole-Cole model that has an entangled parameter at high chargeability m values. Simple testing shows that a Pelton model used to fit resistivity has all four model parameters directly corresponding with conductivity data fitted with a Cole-Cole model. The conclusion is that Cole-Cole and Pelton models in fact require identical independent parameters that can fit experimental or synthetic data, provided the Pelton resistivity formulation is restricted to fitting to resistivity data, and the Cole-Cole conductivity formulation is restricted to fitting conductivity results.

  13. Densification of Ce0.9Gd0.1O1.95 barrier layer by in-situ solid state reaction

    DEFF Research Database (Denmark)

    Ni, De Wei; Esposito, Vincenzo

    2014-01-01

    A novel methodology, called in-situ solid state reaction (SSR), is developed and achieved for the densification of gadolinia doped ceria (CGO) barrier layer (BL) within the solid oxide fuel cell (SOFC) technology. The method is based on the combined use of impregnation technique and a designed two...... out with small amount of either cobalt or copper nitrate solutions as sintering aids. Final sintering of the CGO-BL at temperature T2 (1250e1275 _C, T2 > T1) is used to promote an SSR between the sintering aid and CGO-BL to obtain densification and grain growth. The approach proposed in this work...

  14. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1995-12-01

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

  15. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity...

  16. 10 CFR Appendix B to Part 20 - Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs) of Radionuclides for...

    Science.gov (United States)

    2010-01-01

    .... Actinium Ac 89 Aluminum Al 13 Americium Am 95 Antimony Sb 51 Argon Ar 18 Arsenic As 33 Astatine At 85... Curium Cm 96 Dysprosium Dy 66 Einsteinium Es 99 Erbium Er 68 Europium Eu 63 Fermium Fm 100 Fluorine F...

  17. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    International Nuclear Information System (INIS)

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons

  18. Karina Ramacciotti y Valobra Adriana (comp), Generando el peronismo. Estudios de cultura, política y género (1946-1955), Buenos Aires, Proyecto Editorial, 2004, 195 p.

    OpenAIRE

    Queirolo, Graciela

    2006-01-01

    El peronismo como fenómeno histórico de múltiples facetas atraviesa el siglo XX de la Argentina y le otorga a dicha sociedad un carácter tan particular que ha despertado el interés académico tanto nacional como internacional. Inagotables, y por lo tanto, renovados análisis han sido practicados por las ciencias sociales. Los ensayos compilados por Karina Ramacciotti y Adriana Valobra en Generando el peronismo se inscriben en esta línea y dialogan con las abundantes hipótesis que el campo histo...

  19. Super-GCA connection with tensionless strings: Addendum to “Super-GCA from N=(2,2 super-Virasoro” [Phys. Lett. B 754 (2016 195–200

    Directory of Open Access Journals (Sweden)

    Ipsita Mandal

    2016-09-01

    Full Text Available In this addendum, we consider the connection between certain 2d super-GCA, obtained from the parametric contractions of 2d SCFTs, which can describe the constraint algebra of null spinning strings.

  20. Multibeam collection for KN195-12: Multibeam data collected aboard Knorr from 2009-07-27 to 2009-08-09, departing from Honolulu, HI and returning to Honolulu, HI

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  1. Multibeam collection for KN195-03: Multibeam data collected aboard Knorr from 2009-01-12 to 2009-02-23, departing from Puntarenas, Costa Rica and returning to Honolulu, HI

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  2. Multibeam collection for KN195-05: Multibeam data collected aboard Knorr from 2009-03-24 to 2009-04-05, departing from Puerto Ayora, Ecuador and returning to Puerto Ayora, Ecuador

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  3. American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance U.S. General Services Administration – Project 195 John Seiberling Federal Office Building and U.S. Courthouse, Akron, Ohio

    Energy Technology Data Exchange (ETDEWEB)

    Arends, J.; Sandusky, William F.

    2010-05-28

    This report documents the findings from an onsite audit of the John Seiberling Federal building located in Akron, Ohio. The Federal landlord for this building is the General Services Administration (GSA). The focus of the audit was to identify various no-cost or low-cost energy efficiency opportunities that, once implemented, would reduce in either electrical and gas consumption and increase the operational efficiency of the building. This audit also provided an opportunity to identify potential capital cost projects that should be considered in the to acquire additional energy (electric and gas) and water savings to further increase the operational efficiency of the building.

  4. Comment on "Origin of low-temperature shoulder internal friction peak of Snoek-Köster peak in a medium carbon high alloyed steel" by Lu et al. [Solid State Communications 195 (2014) 31

    Science.gov (United States)

    Hoyos, J. J.; Mari, D.

    2016-01-01

    We want to discuss the interpretation of low-temperature shoulder internal friction peak of Snoek-Köster peak (LTS-SK). Lu et al. (2015) [1] attributed it to the interaction between the carbon atoms and twin boundaries in martensite. Nevertheless, the decrease of the amplitude of LTS-SK peak due to carbon segregation is correlated with the interstitial carbon content in solid solution in martensite (Hoyos et al., 2015 [2]). Therefore, this peak can also be attributed to the presence of an internal friction athermal background, which is proportional to the concentration of interstitial carbon in solid solution (Tkalcec et al., 2015 [2,3]). In addition, they used an alloyed steel, in which ε carbide precipitated above of the LTS-SK peak temperature. As this behavior cannot be generalized for carbon and high alloyed steels, the carbide precipitates could made an additional contribution to the internal friction.

  5. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  6. AcEST: BP912264 [AcEST

    Lifescience Database Archive (English)

    Full Text Available KGDALLFFSLHPSAVPDESSLHTGCPVIEGEKWSATKWIHVAAFEKPRPKNGACV 224 Query: 195 DEDESCGEWAAYGECQKNPTYMIGTSEQPGY 287 +...HGGCPVIEGEKWSATKWIHV S D G+C Sbjct: 200 AVKPRKGDALLFFNLHPDAIPDPLSLHGGCPVIEGEKWSATKWIHVDSFDRIVTPSGNCT 259 Query: 195 DEDESCG...GDALLFFNLHPDAIPDPLSLHGGCPVIEGEKWSATKWIHVDSFDRIVTPSGNCT 259 Query: 195 DEDESCGEWAAYGECQKNPTYMIGTSEQPGY 287 D ...HGGCPVIEGEKWSATKWIHVDSFDKILKPGGNCT 259 Query: 195 DEDESCGEWAAYGECQKNPTYMIGTSEQPG 284 DE++SC WAA GEC KNP YM+G...GDALLFYSLHPNATPDPLSLHGGCPVIQGEKWSATKWIHVDSFDKTVDTEGNCSD 256 Query: 198 EDESCGEWAAYGECQKNPTYMIGTSEQPGY 287 DE

  7. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  8. Production cross section of At radionuclides from $^{7}$Li+$^{\\textrm{nat}}$Pb and $^{9}$Be+$^{\\textrm{nat}}$Tl reactions

    CERN Document Server

    Maiti, Moumita

    2011-01-01

    Earlier we reported theoretical studies on the probable production of astatine radionuclides from $^{6,7}$Li and $^{9}$Be-induced reactions on natural lead and thalliun targets, respectively. For the first time, in this report, production of astatine radionuclides has been investigated experimentally with two heavy ion induced reactions: $^{9}$Be+$^{\\textrm{nat}}$Tl and $^{7}$Li+$^{\\textrm{nat}}$Pb. Formation cross sections of the evaporation residues, $^{207,208,209,210}$At, produced in (HI, xn) channel, have been measured by the stacked-foil technique followed by the off-line $\\gamma$-spectrometry at the low incident energies ($<$50 MeV). Measured excitation functions have been explained in terms of compound nuclear reaction mechanism using Weisskopf-Ewing and Hauser-Feshbach model. Absolute cross section values are lower than the respective theoretical predictions.

  9. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  10. Gclust Server: 36128 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 36128 HSA_21070976 Cluster Sequences - 195 NP_620307.1 diablo isoform 3 precursor ;... to cluster sequences Cluster Sequences Link to related sequences - Sequence length 195 Representative annotation NP_620307.1 diablo

  11. Rainbow of Chaos: A study into the Theory and Practice of Integrated Primary Care: Pim P. Valentijn, [S.l.: s.n.], 2015 (Print Service Ede), pp. 195, Doctoral Thesis Tilburg University, The Netherlands, ISBN: 978-94-91602-40-5.

    Science.gov (United States)

    Valentijn, Pim P

    2016-05-03

    This thesis aimed to contribute to a better understanding of what integrated primary care is, and how it can be achieved by focussing on the collaboration processes that underlie the development of integrated primary care. The first part of this thesis operationalized the concept of integrated care from a primary care perspective. The second part of this thesis described the collaboration mechanisms among integrated care projects that were part of a national integrated primary care study in The Netherlands.

  12. Scholars in International Relations Cite Books More Frequently than Journals: More Research is Needed to Better Understand Research Behaviour and Use. A Review of: Zhang, Li. ʺCitation Analysis for Collection Development: A Study of International Relations Journal Literature.ʺ Library Collections, Acquisitions, and Technical Services 31.3‐4 (2007: 195‐207.

    Directory of Open Access Journals (Sweden)

    Megan von Isenburg

    2009-09-01

    Full Text Available Objective – To determine primary type, format, language and subject category of research materials used by U.S. scholars of international relations. Also, to investigate whether research method, qualitative or quantitative, can be correlated with the type and age of sources that scholars use.Design – Citation analysis.Setting – Research articles published in three journals on international relations with high impact factors: International Organization, International Studies Quarterly, and World Politics.Subjects – A random sample of cited references taken from the 410 full‐length research articles published in these journals from 2000 to 2005. Cited references of articles written by authors of foreign institutions (i.e., non‐American institutions, as well as cited references of editorial and research notes, comments, responses, and review essays were excluded.Methods – Cited references were exported from ISI’s Social Science Citation Index (SSCI to MS Excel spreadsheets for analysis. Data was verified against original reference lists. Citations were numbered and identified by source format, place of publication (foreign or domestic, age, and language used, if other than English. The author used a random number generator to select a random sample of 651 from a total of 29,862 citations. Citations were randomly drawn from each journal according to the proportion of the journals’ citations to the total. These citations were analyzed by material type and language. The author also used the Library of Congress Classification Outline to identify the subject category of each book and journal citation in the sample. A separate sampling method was used to investigate if there is a relationship between research methodology and citation behaviour. Each of the original 410 articles was categorized according to research method: quantitative, qualitative or a combination of the two. Two articles representing qualitative research and two representing quantitative research were randomly selected from each of the three journals for each of the six years. Subsequently, five citations from each of the resulting pool of 72 articles were randomly selected to create a sample of 360 citations. These citations were analyzed by material type and age of source.Main Results – Analysis of the citation data showed that books (including monographs, edited books, book chapters and dictionaries made up 48.2% of the total citations; journals (including scholarly and non‐scholarly titles made up 38.4% of the citations; and government publications made up 4.5% of the citations. Electronic resources, which primarily refer to Web sites and digital collections in this study, represented 1.7% of the citations. Other sources of citations included magazines (1.1%, newspapers (1.1%, working papers (1.1%, theses (0.9%, conference papers not yet published as articles (0.6%, and a miscellaneous category, which included items such as committee minutes, radio broadcasts, unpublished materials and personal communications (2.5%. The average age of book citations was 14.3 years and the median age was 8 years. Foreign language citations represented 3.7% of the 651 total citations. The top ranked foreign languages were German (7, French (5, Russian (4, Spanish (3, Korean (2 and Swedish (number not given. Subject analysis of the citations revealed that 38% of all citations were from international relations and two related disciplines, political science, political theory, and public administration. Subject areas outside international relations included social sciences (23.4% ‐ including economics, commerce, industries and finance, history (16.3%, sociology (6.2%, and law (5.9%. Citations from philosophy, psychology, military science and general works together made up 7.3% of the total citations. Citations from science, linguistics, literature, geography and medicine made up less than 2% of the total.Authors of qualitative research articles were more likely to cite books (56.7% than journals (29.4% while authors of quantitative research articles were more likely to cite journals (58.3% than books (28.9%. Authors of qualitative research articles were also more likely to cite government publications and electronic resources than those of quantitative articles. However, authors of quantitative research articles were more likely to cite other materials, such as dissertations, conference papers, working papers and unpublished materials.The age of cited materials for both qualitative and quantitative research articles is similar. Citations to recent materials up to 5 years old were most frequent, followed by materials 6 to 10 years old, materials 11 to 15 years old, and those 26 or more years old. The least frequently cited materials were 16 to 20 and 21 to 25 years old.Conclusion – Scholars in international relations primarily cite books, followed by journals and government publications. Citations to electronic resources such as Web sites and digital collections, and to other materials are far less common. Scholars primarily cite English‐language materials on international relations and related subjects. Authors of qualitative research articles are more likely to cite books than journals, while authors of quantitative research articles are more likely to cite journals than books. Recent materials are more frequently cited than older materials, though materials that are more than 26 years old are still being cited regularly.

  13. Scholars in International Relations Cite Books More Frequently than Journals: More Research is Needed to Better Understand Research Behaviour and Use. A Review of: Zhang, Li. ʺCitation Analysis for Collection Development: A Study of International Relations Journal Literature.ʺ Library Collections, Acquisitions, and Technical Services 31.3‐4 (2007): 195‐207.

    OpenAIRE

    Megan von Isenburg

    2009-01-01

    Objective – To determine primary type, format, language and subject category of research materials used by U.S. scholars of international relations. Also, to investigate whether research method, qualitative or quantitative, can be correlated with the type and age of sources that scholars use.Design – Citation analysis.Setting – Research articles published in three journals on international relations with high impact factors: International Organization, International Studies Quarterly, and Wor...

  14. Rainbow of Chaos: A study into the Theory and Practice of Integrated Primary Care: Pim P. Valentijn, [S.l.: s.n.], 2015 (Print Service Ede), pp. 195, Doctoral Thesis Tilburg University, The Netherlands, ISBN: 978-94-91602-40-5.

    Science.gov (United States)

    Valentijn, Pim P

    2016-01-01

    This thesis aimed to contribute to a better understanding of what integrated primary care is, and how it can be achieved by focussing on the collaboration processes that underlie the development of integrated primary care. The first part of this thesis operationalized the concept of integrated care from a primary care perspective. The second part of this thesis described the collaboration mechanisms among integrated care projects that were part of a national integrated primary care study in The Netherlands. PMID:27616959

  15. Inclusive measurement of (p,πsup(-)xn) double charge exchange reactions on bismuth from threshold to 800 MeV

    International Nuclear Information System (INIS)

    The energy dependence of the total angle-integrated cross section for the production of astatine isotopes from (p,πsup(-)xn) double charge exchange reactions on bismuth (sup(209)Bi) was measured from 120 to 800 MeV using activation and radiochemical techniques. Chemical yields were estimated by direct radioassaying of sup(211)At activity in thin (approximately 1 mg/cmsup(2)), irradiated bismuth targets. Calculations of the contributions of secondary (2-step) reactions to these measured astatine yields were performed, based partially upon the observed sup(211)At activity although even at the highest energies, the contribution to products lighter than sup(207)At was negligible. These data for products with as many as 7 neutrons removed from the doubly coherent product (sup(210)At) display nearby gaussian shapes for the mass distributions of the astatine residues with the maximum occurring for about sup(204)At. The most probable momentum transfer deduced from these distributions for the initial πsup(-) production step was 335 MeV/c. The observed excitation functions display a behaviour similar to that observed for the yield of sup(210)Po from a (p,πsup(O)) reaction on sup(209)Bi, but radically different from that observed for inclusive πsup(-) reactions on a heavy nucleus. These data are discussed in terms of recent theoretical approaches to negative pion production from bismuth. In addition, a simple, schematic model is developed to treat the rapidly decreasing percentage of the total inclusive πsup(-) emission which is observed for this double charge exchange reaction. This model reflects the capacity of a nucleus to a source of internal energetic protons

  16. Human radiation studies: Remembering the early years: Oral history of Dr. Patricia Wallace Durbin, Ph.D., conducted November 11, 1994

    International Nuclear Information System (INIS)

    This report is a transcript of an interview of Dr. Patricia Wallace Durbin by representatives of the US DOE Office of Human Radiation Research. Dr. Durbin was selected for this interview because of her knowledge of the human plutonium injections and her recollections of key figures, especially Joseph Hamilton. After a brief biographical sketch Dr. Durbin discusses her loss of research funding from DOE, her recollections concerning research into strontium metabolism as part of Project Sunshine, her recollections relating to the rationale for studies of human metabolism of radionuclides, her remembrances of Dr. Hamilton's Astatine and Plutonium research, and her experiences in gathering archival records concerning these researches

  17. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    OpenAIRE

    BAYRAM, Ali

    1998-01-01

    In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 1...

  18. Alpha-decay studies of the new isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At

    CERN Document Server

    Kettunen, H; Grahn, T; Greenlees, P T; Jones, P; Julin, R; Juutinen, S; Keenan, A; Kuusiniemi, P; Leino, M; Leppaenen, A P; Nieminen, P; Pakarinen, J; Rahkila, P; Uusitalo, J

    2003-01-01

    Detailed alpha-decay studies have been performed for the neutron-deficient isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At. The nuclei were produced in fusion-evaporation reactions of sup 5 sup 4 Fe and sup 5 sup 6 Fe ions with a sup 1 sup 4 sup 1 Pr target. The fusion products were separated in-flight using a gas-filled recoil separator and implanted into a position-sensitive silicon detector. The isotopes were identified using position, time and energy correlations between the implants and subsequent alpha-decays. Three alpha-decaying states were identified for sup 1 sup 9 sup 3 At and two for sup 1 sup 9 sup 1 At. The spin and parity of the initial states in the astatine isotopes were deduced based on unhindered alpha-decays to states in the bismuth daughter nuclei. In both astatine isotopes the 1/2 sup + intruder state was determined to be the ground state and a 7/2 sup - state to be the first-excited state. In sup 1 sup 9 sup 3 At the alpha-decay of the 13/2 sup + state was observed in coincidence...

  19. Rationalization of the solvation effects on the AtO+ ground-state change.

    Science.gov (United States)

    Ayed, Tahra; Réal, Florent; Montavon, Gilles; Galland, Nicolas

    2013-09-12

    (211)At radionuclide is of considerable interest as a radiotherapeutic agent for targeted alpha therapy in nuclear medicine, but major obstacles remain because the basic chemistry of astatine (At) is not well understood. The AtO(+) cationic form might be currently used for (211)At-labeling protocols in aqueous solution and has proved to readily react with inorganic/organic ligands. But AtO(+) reactivity must be hindered at first glance by spin restriction quantum rules: the ground state of the free cation has a dominant triplet character. Investigating AtO(+) clustered with an increasing number of water molecules and using various flavors of relativistic quantum methods, we found that AtO(+) adopts in solution a Kramers restricted closed-shell configuration resembling a scalar-relativistic singlet. The ground-state change was traced back to strong interactions, namely, attractive electrostatic interactions and charge transfer, with water molecules of the first solvation shell that lift up the degeneracy of the frontier π* molecular orbitals (MOs). This peculiarity brings an alternative explanation to the highly variable reproducibility reported for some astatine reactions: depending on the production protocols (with distillation in gas-phase or "wet chemistry" extraction), (211)At may or may not readily react. PMID:23944251

  20. Diffusion of Implanted Radioisotopes in Solids

    CERN Multimedia

    2002-01-01

    Implantation of radioisotopes into metal and semiconductor samples is performed. The implanted isotope or its decay-product should have a half-life long enough for radiotracer diffusion experiments. Such radioisotopes are utilized to investigate basic diffusion properties in semiconductors and metals and to improve our understanding of the atomic mechanisms of diffusion. For suitably chosen systems the combination of on-line production and clean implantation of radioisotopes at the ISOLDE facility opens new possibilities for diffusion studies in solids. \\\\ \\\\ The investigations are concentrated on diffusion studies of $^{195}$Au in amorphous materials. The isotope $^{195}$Au was obtained from the mass 195 of the mercury beam. $^{195}$Hg decays into $^{195}$Au which is a very convenient isotope for diffusion experiments. \\\\ \\\\ It was found that $^{195}$Au is a slow diffusor in amorphous Co-Zr alloys, whereas Co is a fast diffusor in the same matrix. The ``asymmetry'' in the diffusion behaviour is of considerab...

  1. New data on cross-sections of deuteron induced nuclear reactions on gold up to 50 MeV and comparison of production routes of medically relevant Au and Hg radioisotopes

    CERN Document Server

    Tárkányi, F; Ditrói, F; Takács, S; Adam-Rebeles, R

    2016-01-01

    Investigations of cross-sections of deuteron induced nuclear reactions on gold were extended up to 50 MeV by using the standard stacked foil irradiation technique and high resolution gamma-ray spectrometry. New cross-sections are reported for the $^{197}$Au(d,xn)$^{197m,197g,195m,195g,193m,193g}$Hg and $^{197}$Au(d,x)$^{198m,198g,196m,196g,195,194}$Au nuclear reactions. The application for production of the medically relevant isotopes $^{198}$Au and $^{195m,195g,197m,197g}$Hg is discussed, including the comparison with other charged particle induced production routes. The possible use of the $^{197}$Au(d,x)$^{197m,197g,195m,193m}$Hg and $^{196m,196g}$Au reactions for monitoring deuteron beam parameters is also investigated.

  2. 大偏心双曲柄单缸柴油机运动规律及工作过程的研究%Characteristics of Motional Law of Large Eccentric Double Crank Connecting Rod Mechanism Adopted in Single Cylinder Diesel Engine and Its Influences on Working Process of Diesel Engines

    Institute of Scientific and Technical Information of China (English)

    王宇; 黄静安; 任成君

    2001-01-01

    本文介绍了在S195型柴油机基础上开发的采用大偏心双曲柄连杆的高速柴油机SLG195的结构特点,并着重分析了SLG195新机型的活塞运动规律及对柴油机工作过程的影响.

  3. A highly conserved phenylalanine in the alpha, beta-T cell receptor (TCR) constant region determines the integrity of TCR/CD3 complexes

    DEFF Research Database (Denmark)

    Caspar-Bauguil, S; Arnaud, J; Huchenq, A;

    1994-01-01

    In the present study, we have investigated the importance of a phenylalanine (phe195) in the Tcr-C alpha region on Tcr-alpha,beta/CD3 membrane expression. An exchange of phe195 with a tyrosine residue does not affect Tcr/CD3 membrane expression; however, exchange with aspartic acid, histidine...

  4. Search for shipwrecks in Goa water

    Digital Repository Service at National Institute of Oceanography (India)

    Thakkar, M.

    stream_size 3 stream_content_type text/plain stream_name 2_Indian_Conf_Mar_Archaeol_I.O._Countries_1990_195.pdf.txt stream_source_info 2_Indian_Conf_Mar_Archaeol_I.O._Countries_1990_195.pdf.txt Content-Encoding ISO-8859-1 Content...

  5. EST Table: BP121240 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BP121240 ceN-4597 10/09/28 90 %/195 aa ref|NP_001037003.1| transitional endoplasmic...48.2#P97 protein#status:Confirmed#UniProt:P54812#protein_id:CAA883 14.1 10/09/10 89 %/195 aa AGAP005630-PA P

  6. NCBI nr-aa BLAST: CBRC-XTRO-01-1829 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-1829 ref|ZP_01436506.1| Drug resistance transporter Bcr/CflA subfamily [Shewanella baltica... OS195] gb|EAU25409.1| Drug resistance transporter Bcr/CflA subfamily [Shewanella baltica OS195] ZP_01436506.1 1.3 29% ...

  7. NCBI nr-aa BLAST: CBRC-AGAM-07-0010 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-07-0010 ref|ZP_01435324.1| amino acid permease-associated region [Shewanella baltica... OS195] gb|EAU26628.1| amino acid permease-associated region [Shewanella baltica OS195] ZP_01435324.1 1e-127 91% ...

  8. NCBI nr-aa BLAST: CBRC-DYAK-04-0065 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DYAK-04-0065 ref|ZP_01432766.1| Lysine exporter protein (LYSE/YGGA) [Shewanella baltica... OS195] gb|EAU28847.1| Lysine exporter protein (LYSE/YGGA) [Shewanella baltica OS195] ZP_01432766.1 9.7 26% ...

  9. NCBI nr-aa BLAST: CBRC-ETEL-01-0618 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0618 ref|ZP_01436206.1| Type III secretion protein SpaR/YscT [Shewanella baltica... OS195] gb|EAU25731.1| Type III secretion protein SpaR/YscT [Shewanella baltica OS195] ZP_01436206.1 3.6 32% ...

  10. NCBI nr-aa BLAST: CBRC-DNOV-01-0498 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0498 ref|ZP_01432923.1| Integral membrane protein TerC [Shewanella baltica... OS195] gb|EAU29004.1| Integral membrane protein TerC [Shewanella baltica OS195] ZP_01432923.1 0.31 32% ...

  11. NCBI nr-aa BLAST: CBRC-DNOV-01-2954 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-2954 ref|ZP_01434771.1| diguanylate cyclase (GGDEF domain) [Shewanella baltica... OS195] gb|EAU27218.1| diguanylate cyclase (GGDEF domain) [Shewanella baltica OS195] ZP_01434771.1 1.1 28% ...

  12. 75 FR 68543 - Airworthiness Directives; Cessna Aircraft Company Models 150, 152, 170, 172, 175, 177, 180, 182...

    Science.gov (United States)

    2010-11-08

    ... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant... Company Models 150, 152, 170, 172, 175, 177, 180, 182, 185, 188, 190, 195, 206, 207, 210, T303, 336, and..., 177, 180, 182, 185, 188, 190, 195, 206, 207, 210, T303, 336, and 337 series airplanes. AD 87-20-03...

  13. Book Review: Organizations: A Systems Approach

    DEFF Research Database (Denmark)

    Schoeneborn, Dennis

    2016-01-01

    Review of: Stefan Kühl: Organizations. A Systems Approach (trans. P. Schmitz). Farnham: Gower Publishing, 2013. 195 pp. £14.99. ISBN 9781472413413.......Review of: Stefan Kühl: Organizations. A Systems Approach (trans. P. Schmitz). Farnham: Gower Publishing, 2013. 195 pp. £14.99. ISBN 9781472413413....

  14. NCBI nr-aa BLAST: CBRC-MMUS-03-0072 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-03-0072 ref|YP_181793.1| tail tape measure protein, TP901 family [Dehaloc...occoides ethenogenes 195] gb|AAW39679.1| tail tape measure protein, TP901 family [Dehalococcoides ethenogenes 195] YP_181793.1 0.56 23% ...

  15. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

    2013-01-01

    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  16. Development of 211At Chemistry for Labelling Biomolecules

    International Nuclear Information System (INIS)

    Our studies have demonstrated that high recovery of 211At can be obtained using a “wet chemistry” approach to isolation from the bismuth target. We have also demonstrated that direct labelling of antibody-B10 conjugates with 211At can be performed in high yields, and that the astatinated antibodies are stable to in vivo deastatination. While these results will allow us to enter clinical studies with 211At-labelled antibodies, the chemistry associated with 211At is not fully understood. Therefore, it is important that many more basic studies to be conducted with 211At, so the optimal labelling reagent for each type of disease-targeting agent becomes apparent

  17. Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status

    DEFF Research Database (Denmark)

    Lyckesvärd, Madeleine Nordén; Delle, Ulla; Kahu, Helena;

    2014-01-01

    Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ((211)At), concentrated in the thyroid by the same...... levels of γH2AX decreased during the first 24h in both cycling and stationary cultures and complete repair was seen in all cultures but cycling cells exposed to (211)At. Compared to stationary cells alpha particles were more harmful for cycling cultures, an effect also seen at the pChk2 levels...... cultures at a modest level of damage, clearly demonstrating that cell cycle status influences the relative effectiveness of alpha particles....

  18. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    Directory of Open Access Journals (Sweden)

    Ali BAYRAM

    1998-03-01

    Full Text Available In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 10, 50 and 259 mm/min. Strength properties of dual-phase steels were investigated depending on annealing temperature, ratio of martensite and loading rate.

  19. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: bruce.marsh@cern.ch [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others

    2013-12-15

    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  20. Analysis of Friction Losses for Double Crank and Connecting Rod Diesel Engine%双曲柄连杆机构柴油机的摩擦损失分析

    Institute of Scientific and Technical Information of China (English)

    王松

    2002-01-01

    对单缸双曲柄连杆机构柴油机(SL195)与单缸单曲柄连杆机构柴油机(L195)的摩擦损失进行了计算分析.并且对(SL195)柴油机和(L195)柴油机进行了实验研究,计算结果与实验结果基本一致.计算结果表明:SL195柴油机的摩擦损失比L195柴油机的摩擦损失约减少了66%,这对提高柴油机的经济性和动力性能有重要实用价值.

  1. EST Table: AU004321 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AU004321 ws20203 10/09/28 85 %/195 aa dbj|BAB16697.1| annexin [Bombyx mori] dbj|BAB16698.1| anne...#CE23956#WBGene00003589#locus:nex- 2#Annexin#status:Confirmed#UniProt:Q27512#protein_id:CAA 82571.2 10/09/10...%/195 aa gnl|Amel|GB16448-PA 10/09/10 72 %/195 aa gi|91092420|ref|XP_967931.1| PREDICTED: similar to Annexin IX CG5730-PC [Tribolium castaneum] NM_001043376 ws2 ...

  2. Interaction between three subpopulations of Ehrlich carcinoma in mixed solid tumours in nude mice: evidence of contact domination

    DEFF Research Database (Denmark)

    Aabo, K; Vindeløv, L L; Spang-Thomsen, M

    1994-01-01

    growth in ascitic fluid in which the cells had no intimate contact. Ascitic fluid from E1.95-bearing animals or radiation-killed E1.95 cells had no effect on the growth of E1.15, and no remote effect was seen when the two cell lines were growing in opposite flanks. This indicates that only viable E1...... line had no dominating effect on the E1.15 or E1.95. It is concluded that non-immunologically mediated cellular dominance in heterogeneous tumours may contribute to the evolution of these tumours and may be involved in fundamental tumour biological phenomena....

  3. Drug: D09967 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ide bridge: 23-89; 135-195; H230-L215, Dimer) Peptide Uveitis, rheumatoid arthritis, psoriasis ATC code: L04...teraction hsa05323(3605) Rheumatoid arthritis map07050 Antirheumatics - DMARDs and biological agents Anatomi

  4. CERN'S Fire and Rescue Group Gets New Ambulance

    CERN Multimedia

    2000-01-01

    The ambulance is to replace another based on the off-road vehicle design which was originally acquired for the civil engineering phase of LEP construction. Just one figure, in 1999, the CERN ambulance was called out 195 times.

  5. 48 CFR 1823.570 - Drug- and alcohol-free workforce.

    Science.gov (United States)

    2010-10-01

    ..., OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Drug-Free Workplace 1823.570 Drug- and alcohol-free workforce.... 2473, 72 Stat. 429; and Civil Space Employee Testing Act of 1991, Public Law 102-195, sec. 21, 105...

  6. 42 CFR 84.2 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... produce physical discomfort immediately, chronic poisoning after repeated exposure, or acute adverse... contains an oxygen partial pressure of less than 148 millimeters of mercury (19.5 percent by volume at...

  7. Eimuntas Nekroshiuse teatripoeetika / Ruta Mazheikiene ; tõlk. Tiina Kattel

    Index Scriptorium Estoniae

    Mazheikiene, Ruta

    2004-01-01

    E. Nekroshiuse lavastustele iseloomulikest joontest, toetudes tema lavastustele "Hamlet" "Macbeth", "Othello", "Onu Vanja", "Nina". Samuti näitlejatega töötamise strateegiast. Kasut. kirjandus, lk. 194-195

  8. Locus of Control and Achievement Motivation as Moderators of the Expectancy-Academic Performance Relationship

    Science.gov (United States)

    Batlis, Nick C.; Waters, L. K.

    1973-01-01

    Expectancy theory predictions of course performance were tested for a sample of 195 undergraduates; significant prediction was attained for the total sample using a log linear expectancy model. (Author)

  9. 17-OH progesterone

    Science.gov (United States)

    ... In: Speroff L, Fritz MA, eds. Clinical Gynecologic Endocrinology and Infertility . 8th ed. Philadelphia, PA: Lippincott Williams & ... Am . 2010; 37(2):195-205. Mark T. Endocrinology. In: Engorn B, Flerlage J, eds. Johns Hopkins: ...

  10. Disease: H01113 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H01113 Acid phosphatase deficiency Acid phosphatase deficiency is caused by defects...(1970) PMID:4139985 Nadler HL Treatment of acid phosphatase deficiency disorders. Birth Defects Orig Artic Ser 9:195-7 (1973) ...

  11. Double-electron above-threshold ionization resonances as interference phenomena

    Science.gov (United States)

    Armstrong, G. S. J.; Parker, J. S.; Taylor, K. T.

    2012-11-01

    We present high-accuracy full-dimensionality calculations of total kinetic energy spectra of doubly-ionized helium at 195 nm. We find that the resonances in these spectra have their origins as interference phenomena.

  12. Structuring mobile and contextual learning

    NARCIS (Netherlands)

    Glahn, Christian; Specht, Marcus

    2011-01-01

    Glahn, C., & Specht, M. (2011). Structuring mobile and contextual learning. In Proceedings of the 10th World Conference on Mobile and Contextual Learning (pp. 188-195). October, 18-21, 2011, Beijing, China.

  13. Wisconsin Gravity Data for the Rhinelader Area

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The gravity station data (195 records) were compiled by Barbara Eckstein. This data base was received in January 1987. Principal gravity parameters include Free-Air...

  14. Isolation of a bacterium that reductively dechlorinates tetrachloroethene to ethene

    Energy Technology Data Exchange (ETDEWEB)

    Maymo-Gatell, X.; Chien, Yueh-tyng; Zinder, S.H. [Cornell Univ., Ithaca, NY (United States)] [and others

    1997-06-06

    Tetrachloroethene is a prominent groundwater pollutant that can be reductively dechlorinated by mixed anaerobic microbial populations to the nontoxic product ethene. Strain 195, a coccoid bacterium that dechlorinates tetrachlorethene to ethene, was isolated and characterized. Growth of strain 195 with H{sub 2} and tetrachloroethene as the electron donor and acceptor pair required extracts from mixed microbial cultures. Growth of strain 195 was resistant to ampicillin and vancomycin; its cell wall did not react with a peptidoglycan-specific lectin and its ultrastructure resembled S-layers of Archaea. Analysis of the 16S ribosomal DNA sequence of strain 195 indicated that it is a eubacterium without close affiliation to any known groups. 24 refs., 4 figs., 1 tab.

  15. Absolute absorption cross-section measurements of ozone in the wavelength region 238-335 nm and the temperature dependence

    Science.gov (United States)

    Yoshino, K.; Freeman, D. E.; Esmond, J. R.; Parkinson, W. H.

    1988-01-01

    The absolute absorption cross-section of ozone has been experimentally determined at the temperatures 195, 228, and 295 K at several discrete wavelengths in the 238-335-nm region. The present results for ozone at 295 K are found to be in agreement with those of Hearn (1961). Absolute cross-section measurements of ozone at 195 K have confirmed previous (Freeman et al., 1984) relative cross-section measurements throughout the 240-335-nm region.

  16. EST Table: FS866811 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available ar to voltage-dependent anion-selective channel isoform 1 [Tribolium castaneum] 10/09/11 58 %/195 aa FBpp016...7024|DmojGI17807-PA 10/08/29 32 %/195 aa R05G6.7#CE29443#WBGene00019900#Channel Protein#status:Confirmed#Uni...1|ref|XP_967480.1| PREDICTED: similar to voltage-dependent anion-selective channel isoform 1 [Tribolium castaneum] FS819264 fner ...

  17. Genetic and bibliographic information: EYA4 [GenLibi

    Lifescience Database Archive (English)

    Full Text Available EYA4 eyes absent homolog 4 (Drosophila) human Cardiomyopathy, Dilated (MeSH); dilat...ed cardiomyopathy; sensorineural hearing loss Cardiovascular Diseases (C14) > Heart Diseases (C14.280) > Card...iomegaly (C14.280.195) > Cardiomyopathy, Dilated (C14.280.195.160) Cardiovascular Diseases (C14) > Heart Diseases (C14.280) > Card...iomyopathies (C14.280.238) > Cardiomyopathy, Dilated (C14.280.238.070) 05A0344219 ...

  18. Low cost removal of reactive dyes using wheat bran

    International Nuclear Information System (INIS)

    In this study, the adsorption of Reactive Blue 19 (RB 19), Reactive Red 195 (RR 195) and Reactive Yellow 145 (RY 145) onto wheat bran, generated as a by-product material from flour factory, was studied with respect to initial pH, temperature, initial dye concentration, adsorbent concentration and adsorbent size. The adsorption of RB 19, RR 195 and RY 145 onto wheat bran increased with increasing temperature and initial dye concentration while the adsorbed RB 19, RR 195 and RY 145 amounts decreased with increasing initial pH and adsorbent concentration. The Langmuir and Freundlich isotherm models were applied to the experimental equilibrium data depending on temperature and the isotherm constants were determined by using linear regression analysis. The monolayer covarage capacities of wheat bran for RB 19, RR 195 and RY 145 dyes were obtained as 117.6, 119.1 and 196.1 mg/g at 60 deg. C, respectively. It was observed that the reactive dye adsorption capacity of wheat bran decreased in the order of RY 145 > RB 19 > RR 195. The pseudo-second order kinetic and Weber-Morris models were applied to the experimental data and it was found that both the surface adsorption as well as intraparticle diffusion contributed to the actual adsorption processes of RB 19, RR 195 and RY 145. Regression coefficients (R 2) for the pseudo-second order kinetic model were higher than 0.99. Thermodynamic studies showed that the adsorption of RB 19, RR 195 and RY 145 dyes onto wheat bran was endothermic in nature

  19. Gclust Server: 191939 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 191939 HSA_30425524 Cluster Sequences - 195 NP_848647.1 hypothetical protein LOC339...669 ; no annotation 1 1.00e-99 0.0 0.0 0.0 0.0 0.0 12.5 Show 191939 Cluster ID 191939 Sequence ID HSA_304255...24 Link to cluster sequences Cluster Sequences Link to related sequences - Sequence length 195 Representativ

  20. Culture, Cross-Role Consistency, and Adjustment: Testing Trait and Cultural Psychology Perspectives

    OpenAIRE

    Church, A. Timothy; Anderson-Harumi, Cheryl A.; del Prado, Alicia M.; Curtis, Guy J.; Tanaka-Matsumi, Junko; Valdez Medina, José L.; Mastor, Khairul A.; White, Fiona A.; Miramontes, Lilia A.; Katigbak, Marcia S.

    2008-01-01

    Trait and cultural psychology perspectives on cross-role consistency and its relation to adjustment were examined in two individualistic cultures, the United States (N = 231) and Australia (N = 195), and four collectivistic cultures, Mexico (N = 199), Philippines (N = 195), Malaysia (N = 217), and Japan (N = 180). Cross-role consistency in trait ratings was evident in all cultures, supporting trait perspectives. Cultural comparisons of mean consistency provided support for cultural psychology...

  1. AcEST: DK947599 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ILTE Maturase K OS=Pillansia templemannii GN=mat... 30 5.1 sp|Q4H195|MATK_LAPNE Maturase K OS=Lapeirousia neglect...urase K OS=Lapeirousia neglecta GN=matK PE=3 SV=1 Length = 522 Score = 30.0 bits ...YYFHFWYQSYRIHINQLSKHSFHFLGYLSSLLKNSST 359 Query: 231 PRN 239 RN Sbjct: 360 VRN 362 >sp|Q4H195|MATK_LAPNE Mat

  2. Regulation of actin catch-slip bonds with a RhoA-formin module

    Science.gov (United States)

    Lee, Cho-Yin; Lou, Jizhong; Wen, Kuo-Kuang; McKane, Melissa; Eskin, Suzanne G.; Rubenstein, Peter A.; Chien, Shu; Ono, Shoichiro; Zhu, Cheng; McIntire, Larry V.

    2016-10-01

    The dynamic turnover of the actin cytoskeleton is regulated cooperatively by force and biochemical signaling. We previously demonstrated that actin depolymerization under force is governed by catch-slip bonds mediated by force-induced K113:E195 salt-bridges. Yet, the biochemical regulation as well as the functional significance of actin catch bonds has not been elucidated. Using AFM force-clamp experiments, we show that formin controlled by RhoA switches the actin catch-slip bonds to slip-only bonds. SMD simulations reveal that the force does not induce the K113:E195 interaction when formin binds to actin K118 and E117 residues located at the helical segment extending to K113. Actin catch-slip bonds are suppressed by single residue replacements K113E and E195K that interrupt the force-induced K113:E195 interaction; and this suppression is rescued by a K113E/E195K double mutant (E/K) restoring the interaction in the opposite orientation. These results support the biological significance of actin catch bonds, as they corroborate reported observations that RhoA and formin switch force-induced actin cytoskeleton alignment and that either K113E or E195K induces yeast cell growth defects rescued by E/K. Our study demonstrates how the mechano-regulation of actin dynamics is modulated by biochemical signaling molecules, and suggests that actin catch bonds may be important in cell functions.

  3. Medial patellofemoral ligament injury patterns and associated pathology in lateral patella dislocation: an MRI study

    Directory of Open Access Journals (Sweden)

    Guerrero Patrick

    2009-07-01

    Full Text Available Abstract Background Lateral Patella dislocations are common injuries seen in the active and young adult populations. Our study focus was to evaluate medial patellofemoral ligament (MPFL injury patterns and associated knee pathology using Magnetic Resonance Imaging studies. Methods MRI studies taken at one imaging site between January, 2007 to January, 2008 with the final diagnosis of patella dislocation were screened for this study. Of the 324 cases that were found, 195 patients with lateral patellar dislocation traumatic enough to cause bone bruises on the lateral femoral trochlea and the medial facet of the patella were selected for this study. The MRI images were reviewed by three independent observers for location and type of MPFL injury, osteochondral defects, loose bodies, MCL and meniscus tears. The data was analyzed as a single cohort and by gender. Results This study consisted of 127 males and 68 females; mean age of 23 yrs. Tear of the MPFL at the patellar attachment occurred in 93/195 knees (47%, at the femoral attachment in 50/195 knees (26%, and at both the femoral and patella attachment sites in 26/195 knees (13%. Attenuation of the MPFL without rupture occurred in 26/195 knees (13%. Associated findings included loose bodies in 23/195 (13%, meniscus tears 41/195 (21%, patella avulsion/fracture in 14/195 (7%, medial collateral ligament sprains/tears in 37/195 (19% and osteochondral lesions in 96/195 knees (49%. Statistical analysis showed females had significantly more associated meniscus tears than the males (27% vs. 17%, p = 0.04. Although not statistically significant, osteochondral lesions were seen more in male patients with acute patella dislocation (52% vs. 42%, p = 0.08. Conclusion Patients who present with lateral patella dislocation with the classic bone bruise pattern seen on MRI will likely rupture the MPFL at the patellar side. Females are more likely to have an associated meniscal tear than males; however, more males

  4. Hepatorenal protective effect of Antistax ® against chemically-induced toxicity

    Directory of Open Access Journals (Sweden)

    Atallah F Ahmed

    2015-01-01

    Full Text Available Background: Antioxidant natural products and chemoprevention are considered nowadays as an effective approach against health various disorders and diseases induced by oxidative stress or free radicals. Objective: The aim of this study was to assess the hepato- and nephroprotective activity of a standardized red vine leaf aqueous extract AS195 (Antistax ® . Methods: The protective activity of AS195 (100 mg/kg was investigated on carbon tetrachloride (CCl 4 -intoxicated rats in comparison with silymarin. The flavonoid/proanthocyanidin nature of AS195 was identified by phytochemical and nuclear magnetic resonance (NMR analyses, while its total phenol/proanthocyanidin/flavonoid content and antioxidant activity were determined by Folin-Ciocalteau, vanillin-sulfuric acid, AlCl 3 , and 2,2-diphenyl-2-picrylhydrazyl radical scavenging assays, respectively. Results: Relative to the control CCl 4 -intoxicated group, pretreatment with AS195 could significantly suppressed the elevated serum levels of alanine aminotransferase, alkaline phosphatase, γ-glutamyl transferase, total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, triglycerides, bilirubin, creatinine, uric acid, and calcium, whereas it significantly increased the diminished serum levels of high-density lipoprotein cholesterol, albumin and total protein. Moreover, AS195 significantly decreased malondialdehyde formation in the tissues of liver and kidney, whereas it significantly elevated and nonprotein sulfhydryl groups, compared with the intoxicated control. The improvement in biochemical parameters by AS195 was obviously observed and further confirmed by restoration of normal histological features in the two organs. Conclusions: The results of the present study revealed the capacity of AS195 to enhance the recovery from xenobiotic-induced hepatorenal toxicity initiated by free radicals.

  5. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  6. The biokinetics of alpha-particle emitting radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, D.M. [School of Chemistry, Cardiff Univ., Cardiff (United Kingdom); Duffield, J.R. [Faculty of Applied Sciences, Univ. of the West of England, Bristol (United Kingdom)

    2005-07-01

    The past two decades have seen wide interest in the application of alpha-particle emitting radionuclides for targeted endoradiotherapy and a large number of compounds labeled with {sup 211}At (T{sup 1}/{sub 2} 7.21 h), {sup 212}Bi (T{sup 1}/{sub 2} 1 h) or {sup 213}Bi (T{sup 1}/{sub 2} 0.78 h) have been studied. Knowledge of the biokinetic behaviour of such agents is important both for their optimal clinical exploitation and for general radiological protection purposes. Animal studies of the distribution and retention of {sup 211}At compounds, including ionic astatide, substituted aromatic compounds and labelled monoclonal antibodies, have provided new information on the biochemistry of astatine. With respect the thyroid gland the uptake of the astatide ion has been shown to be very much lower than that of the iodide ion. Less information is available for {sup 212}Bi-labelled radiopharmaceuticals. The available data for both {sup 211}At and {sup 212}Bi radiopharmaceuticals are reviewed. Cautious generic biokinetic models for inorganic and simple organic compounds of {sup 211}At and {sup 212}Bi; for [{sup 211}At]-, and [{sup 212}Bi]-biphosphonates and for [{sup 211}At]-, and [{sup 212}Bi]-monoclonal antibodies, are proposed for use in general radiological protection when compound-specific data are not available. (orig.)

  7. Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with {sup 211}At-EGF

    Energy Technology Data Exchange (ETDEWEB)

    Sundberg, Aasa Liljegren; Orlova, Anna; Gedda, Lars; Tolmachev, Vladimir; Carlsson, Joergen [Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala (Sweden); Almqvist, Ylva [Division of Radiology, Uppsala University, Uppsala (Sweden); Blomquist, Erik [Division of Oncology, Uppsala University, Uppsala (Sweden); Jensen, Holger J. [Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Rigshospitalet, Copenhagen (Denmark)

    2003-10-01

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib ['Iressa' (trademark of the AstraZeneca group of companies), ZD1839] increases the cellular uptake of radiolabelled epidermal growth factor (EGF). We investigated gefitinib treatment combined with astatine-211 EGF targeting in vitro using two cell lines expressing high levels of EGFR: A431 (sensitive to gefitinib) and U343MGaCl2:1 (resistant to gefitinib). In both cell lines, the uptake of {sup 211}At-EGF was markedly increased by concomitant treatment with gefitinib. Survival was investigated using both a clonogenic survival assay and a cell growth assay. Combined gefitinib and {sup 211}At-EGF treatment reduced the survival of U343 cells 3.5-fold compared with {sup 211}At-EGF alone. In A431 cells, {sup 211}At-EGF treatment resulted in very low survival, but combined treatment with gefitinib increased the survival by about 20-fold. These results indicate that combined treatment with gefitinib might increase the effect of ligand-mediated radionuclide therapy in gefitinib-resistant tumours and decrease the effect of such therapy in gefitinib-sensitive tumours. (orig.)

  8. Alpha particle emitters in medicine

    International Nuclear Information System (INIS)

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 (211At) and natural bismuth-212 (212Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 (223Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs

  9. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  10. Development of Reagents for Application of At-211 to Targeted Radionuclide Therapy of Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott

    2011-12-23

    This grant covered only a period of 4 months as the major portion of the award was returned to DOE due to an award of funding from NIH that covered the same research objectives. A letter regarding the termination of the research is attached as the last page of the Final Report. The research conducted was limited due to the short period of this grant, but the results obtained in that period are outlined in the Final Report. The studies addressed in the research effort were directed at a problem that is of critical importance to the in vivo application of the alpha-particle emitting radionuclide At-211. That problem, low in vivo stability of many astatinated molecules, severely limits the use of At-211 in therapeutic applications. The advances sought in the studies were expected to expand the types of biomolecules that can be used as carriers of At-211, and provide improved in vivo targeting of the radiation dose compared with the dose delivered to normal tissue.

  11. Tumor immunotargeting using innovative radionuclides.

    Science.gov (United States)

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  12. SPECT assay of radiolabeled monoclonal antibodies. Progress report, September 1, 1992--August 24, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1993-08-20

    The overall goal of this project is to improve the effectiveness of single photon emission computed tomography (SPECT) to image and quantify radiolabeled monoclonal antibodies. During the past year, we have made significant progress toward this goal, and this report summarizes that work. Our efforts have been mainly directed along three fronts. First, we have developed and tested new reconstruction methods including three-dimensional iterative algorithms that model non-uniform attenuation and distance-dependent detector response. Both fan beam and parallel beam collimator geometries have been modeled and novel ways of improving the efficiency of the computationally intensive methods have been introduced. Second, an ultra-high resolution, small field-of-view pinhole collimator has been constructed and evaluated. Reconstructed spatial resolution of 1 to 3 mm (FWHM) has been achieved in phantom scans with a useful field-of-view of 9 to 10 cm. Finally, we have investigated the ability of SPECT to image and quantify astatine-211 distributions. Reconstructed images of phantom data demonstrated quantitative accuracy to within 10% with proper attenuation and scatter compensation.

  13. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  14. Nuclear and chemical data for life sciences

    International Nuclear Information System (INIS)

    Use of reactor produced radionuclides is popular in life sciences. However, cyclotron production of proton rich radionuclides are being more focused in recent times. These radionuclides have already gained attention in various fields, including life sciences, provided they are obtained in pure form. This article is a representative brief of our contributions in generating nuclear data for the production of proton rich radionuclides of terbium, astatine, technetium, ruthenium, cadmium, niobium, zirconium, rhenium, etc., which may have application in clinical, biological, agriculture studies or in basic research. The chemical data required to separate the product isotopes from the corresponding target matrix have been presented along with a few propositions of radiopharmaceuticals. It also emphasizes on the development of simple empirical technique, based on the nuclear reaction model analysis, to generate reliable nuclear data for the estimation of yield and angular distribution of emitted neutrons and light charged particles from light as well as heavy ion induced reactions on thick stopping targets. These data bear utmost important in radiation dosimetry. (author)

  15. Studies of Stable Octupole Deformations in the Radium Region

    CERN Multimedia

    2002-01-01

    The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

  16. Alpha particle emitters in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, D.R.

    1989-09-01

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ({sup 211}At) and natural bismuth-212 ({sup 212}Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ({sup 223}Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

  17. Accuracy of implant positioning for minimally invasive total knee arthroplasty in patients with severe varus deformity.

    Science.gov (United States)

    Niki, Yasuo; Matsumoto, Hideo; Otani, Toshiro; Enomoto, Hiroyuki; Toyama, Yoshiaki; Suda, Yasunori

    2010-04-01

    Minimally invasive surgery (MIS) in total knee arthroplasty (TKA) reportedly yields decreased patient morbidity and a rapid return of function, but how much deformity can be accepted for MIS-TKA remains unclear. This study investigated 238 knees from 218 consecutive patients who underwent MIS-TKA. Patients were divided into groups with tibiofemoral mechanical axis (TFM) 195 degrees or greater and TFM less than 195 degrees, then clinical and radiographic results were compared. Similar improvements in knee score at 3 months postoperatively were obtained in the both groups, whereas radiographic accuracy of the coronal alignment in the TFM >or=195 degrees group was inferior to that in TFM angle of the femoral shaft (LBFS) 4 degrees or greater, and 53% of patients in the TFM >or=195 degrees group displayed LBFS 4 degrees or greater, explaining the inferior radiographic accuracy in this group compared with the TFM <195 degrees group. These results indicate that use of MIS techniques decreases radiographic accuracy, particularly in patients with severe genu varum and increased LBFS. PMID:20347714

  18. Activation cross-sections of deuteron induced nuclear reactions on gold up to 40 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Tarkanyi, F. [Institute of Nuclear Research of the Hungarian Academy of Sciences (ATOMKI), Debrecen (Hungary); Ditroi, F., E-mail: ditroi@atomki.hu [Institute of Nuclear Research of the Hungarian Academy of Sciences (ATOMKI), Debrecen (Hungary); Hermanne, A. [Cyclotron Laboratory, Vrije Universiteit Brussel (VUB), Brussels (Belgium); Takacs, S.; Kiraly, B. [Institute of Nuclear Research of the Hungarian Academy of Sciences (ATOMKI), Debrecen (Hungary); Yamazaki, H.; Baba, M.; Mohammadi, A. [Cyclotron and Radioisotope Center (CYRIC), Tohoku University, Sendai (Japan); Ignatyuk, A.V. [Institute of Physics and Power Engineering (IPPE), Obninsk (Russian Federation)

    2011-06-15

    Cross-sections of deuteron induced nuclear reactions on gold were measured up to 40 MeV by using the standard stacked foil irradiation technique and high resolution gamma-ray spectroscopy. Experimental cross-sections and derived integral yields are reported for the {sup 197}Au(d,xn){sup 197m,197g,195m,195g}Hg and {sup 197}Au(d,x){sup 198g,196m,196g,195,194}Au nuclear reactions. The experimental data are analyzed and compared to literature and predictions of the ALICE-IPPE, EMPIRE and TALYS theoretical model codes. The application of the new cross-sections for accelerator technology, medical radioisotope production, thin layer activation and dose calculation is discussed.

  19. Activation cross sections of proton induced nuclear reactions on gold up to 65 MeV

    CERN Document Server

    Ditrói, F; Takács, S; Hermanne, A

    2016-01-01

    Activation cross sections of proton induced reactions on gold for production of $^{197m,197g,195m,195g, 193m,193g,192}$Hg, $^{196m,196g(cum),195g(cum),194,191(cum)}$Au, $^{191(cum)}$Pt and $^{192}$Ir were measured up to 65 MeV proton energy, some of them for the first time. The new data are in acceptably good agreement with the recently published earlier experimental data in the overlapping energy region. The experimental data are compared with the predictions of the TALYS 1.6 (results in TENDL-2015 on-line library) and EMPIRE 3.2 code.

  20. Spectroscopy of A˜190 Ir-Pt-Au Nuclei Near Stability from Complete and Incomplete Fusion Reaction

    Science.gov (United States)

    Fang, Y. D.; Zhang, Y. H.; Zhou, X. H.; Liu, M. L.; Wang, J. G.; Guo, Y. X.; Lei, X. G.; Hua, W.; Ma, F.; Wang, S. C.; Gao, B. S.; Li, S. C.; Wu, X. G.; He, C. Y.; Zheng, Y.; Wang, Z. M.; Shi, Y.; Xu, F. R.

    2013-11-01

    High-spin states of 194, 195Au, 195Pt and 193Ir have been studied using an in-beam γ-ray spectroscopic technique following the reaction of 7Li on an 192Os target at 44 MeV. The emitted γ rays were observed using an array of 14 Compton-suppressed HPGe detectors. Several bands in these nuclei have been identified and extended up to high-spin states. The α and t emission channels leading to 193Ir and 195Pt, respectively, are strongly enhanced which may be explained by incomplete fusion reaction; the t and α fragments from the break-up of weakly bound 7Li nucleus fusion with 192Os target.

  1. Why Ser and not Thr brokers catalysis in the trypsin fold.

    Science.gov (United States)

    Pelc, Leslie A; Chen, Zhiwei; Gohara, David W; Vogt, Austin D; Pozzi, Nicola; Di Cera, Enrico

    2015-02-24

    Although Thr is equally represented as Ser in the human genome and as a nucleophile is as good as Ser, it is never found in the active site of the large family of trypsin-like proteases that utilize the Asp/His/Ser triad. The molecular basis of the preference of Ser over Thr in the trypsin fold was investigated with X-ray structures of the thrombin mutant S195T free and bound to an irreversible active site inhibitor. In the free form, the methyl group of T195 is oriented toward the incoming substrate in a conformation seemingly incompatible with productive binding. In the bound form, the side chain of T195 is reoriented for efficient substrate acylation without causing steric clash within the active site. Rapid kinetics prove that this change is due to selection of an active conformation from a preexisting ensemble of reactive and unreactive rotamers whose relative distribution determines the level of activity of the protease. Consistent with these observations, the S195T substitution is associated with a weak yet finite activity that allows identification of an unanticipated important role for S195 as the end point of allosteric transduction in the trypsin fold. The S195T mutation abrogates the Na(+)-dependent enhancement of catalytic activity in thrombin, activated protein C, and factor Xa and significantly weakens the physiologically important allosteric effects of thrombomodulin on thrombin and of cofactor Va on factor Xa. The evolutionary selection of Ser over Thr in trypsin-like proteases was therefore driven by the need for high catalytic activity and efficient allosteric regulation. PMID:25664608

  2. Dicty_cDB: AFK493 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available elim): 0 length of query: 195 length of database: 80,480,566 effective HSP length: 17 effective... length of query: 178 effective length of database: 78,821,179 effective search space: 14030169862 effective... Number of sequences better than 10.0: 0 length of query: 195 length of database: Z,213,015,108 effective HSP length: 22 effective... length of query: 173 effective length of database: Y,388,266,194 effective... search space: 7160170051562 effective search space used: 7160170051562 T: 0 A: 0 X1: 6 (11.

  3. From the UV to the static-field limit: Rates and scaling laws for intense-field ionization of helium

    International Nuclear Information System (INIS)

    We present high-accuracy calculations of ionization rates of helium at UV (195 nm) wavelengths. The numerical results are obtained from full-dimensional numerical integration of the two-electron time-dependent Schroedinger equation. Comparison is made between ionization rates at 195 nm with previously obtained data at 390 nm and 780 nm. In addition, we have obtained quantitatively accurate solutions of the full-dimensional time-dependent Schroedinger equation for static-field ionization of helium. We compare our numerically integrated rates with those of time-independent calculations, and obtain good agreement over a wide range of intensities.

  4. NCBI nr-aa BLAST: CBRC-ACAR-01-0970 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ACAR-01-0970 ref|ZP_01433876.1| NADH [Shewanella baltica OS195] ref|YP_0010493...19.1| NADH:ubiquinone oxidoreductase, subunit B [Shewanella baltica OS155] ref|ZP_01841447.1| NADH:ubiquinon...e oxidoreductase, subunit B [Shewanella baltica OS223] gb|EAU28006.1| NADH [Shewanella baltica OS195] gb|ABN...60450.1| NADH:ubiquinone oxidoreductase, subunit B [Shewanella baltica OS155] gb|...EDK50875.1| NADH:ubiquinone oxidoreductase, subunit B [Shewanella baltica OS223] ZP_01433876.1 0.52 33% ...

  5. Book Review Society and the object. Views from the identity, design and information / Reseña La sociedad y el objeto. Miradas desde la identidad, diseño e información

    Directory of Open Access Journals (Sweden)

    Jesús Manuel Fitch Osuna

    2014-03-01

    Full Text Available Book Review: Mercedes Mercado; Álvaro Ríos; Liliana Sosa; and Gerardo Vázquez (2012 Identity, design, information. Publisher: University of Nuevo León, Monterrey (Mexico. Pages: 195. ISBN: 978-607-27-0016-1. Reseña del libro: Mercedes Mercado; Álvaro Ríos; Liliana Sosa; y Gerardo Vázquez (2012: Identidad, diseño, información. Editorial: Universidad Autónoma de Nuevo León, Monterrey (México. Páginas: 195. ISBN: 978-607-27-0016-1.

  6. EST Table: CK533832 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK533832 rswgb0_001886.y1 10/09/29 44 %/195 aa ref|XP_974065.1| PREDICTED: similar to Outer dense fiber... protein 2 (Outer dense fiber of sperm tails protein 2) (84 kDa outer dense fiber protei.../168 aa gnl|Amel|GB14311-PA 10/09/10 44 %/195 aa gi|91078946|ref|XP_974065.1| PREDICTED: similar to Outer dense fiber... protein 2 (Outer dense fiber of sperm tails protein 2) (84 kDa outer dense fiber protein) (Cenexin) [Tribolium castaneum] CK536834 swg ...

  7. AcEST: BP919643 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ngth = 485 Score = 193 bits (490), Expect = 5e-49 Identities = 100/112 (89%), Positives = 102/112 (91%) Frame = -1 Query: 531 EGSITS...ignificant alignments: (bits) Value sp|Q95AD7|ATPB_PHOTN ATP synthase subunit beta, chloroplastic OS... 195 ...ynthase subunit beta, chloroplastic OS=Phormium tenax GN=atpB PE=3 SV=1 Length = 498 Score = 195 bits (496),... Expect = 1e-49 Identities = 101/112 (90%), Positives = 103/112 (91%) Frame = -1 Query: 531 EGSITSIQAVYVPAGD...LTDPAPATTFAHLDATTALSRGLAAKGIYSAVDPLDSTSTMLQP 352 EGSITSIQAVYVPA DLTDPAPATTFAHLDAT

  8. Spectral Classification of Optical Counterparts to ROSAT All-Sky Survey X-ray Sources

    CERN Document Server

    Dragomir, D; Rutledge, R E; Dragomir, Diana; Roy, Philippe; Rutledge, Robert E.

    2007-01-01

    Previous work statistically identified 5492 optical counterparts, with approximately 90% confidence, from among the approximately 18,000 X-ray sources appearing in the ROSAT All-Sky Survey Bright Source Catalog (RASS/BSC). Using low resolution spectra in the wavelength range 3700-7900 angstroms, we present spectroscopic classifications for 195 of these counterparts which have not previously been classified. Of these 195, we find 168 individual stars of F, G, K or M type, 6 individual stars of unknown type, 6 double stars, 6 AGN or galaxies and 7 unclassifiable objects; the spectra of the 2 remaining objects were saturated.

  9. Mammalian Flavin-Containing Monooxygenase (FMO) as a Source of Hydrogen Peroxide

    OpenAIRE

    Siddens, Lisbeth K.; Krueger, Sharon K.; Henderson, Marilyn C.; Williams, David E.

    2014-01-01

    Flavin-containing monooxygenase (FMO) oxygenates drugs/xenobiotics containing a soft nucleophile through a C4a hydroperoxy-FAD intermediate. Human FMOs 1, 2 and 3, expressed in Sf9 insect microsomes, released 30–50% of O2 consumed as H2O2 upon addition of NADPH. Addition of substrate had little effect on H2O2 production. Two common FMO2 (the major isoform in the lung) genetic polymorphisms, S195L and N413K, were examined for generation of H2O2. FMO2 S195L exhibited higher “l...

  10. From the UV to the static-field limit: Rates and scaling laws for intense-field ionization of helium

    Science.gov (United States)

    Armstrong, G. S. J.; Parker, J. S.; Boca, M.; Taylor, K. T.

    2009-11-01

    We present high-accuracy calculations of ionization rates of helium at UV (195 nm) wavelengths. The numerical results are obtained from full-dimensional numerical integration of the two-electron time-dependent Schrödinger equation. Comparison is made between ionization rates at 195 nm with previously obtained data at 390 nm and 780 nm. In addition, we have obtained quantitatively accurate solutions of the full-dimensional time-dependent Schrödinger equation for static-field ionization of helium. We compare our numerically integrated rates with those of time-independent calculations, and obtain good agreement over a wide range of intensities.

  11. Physical Activity

    DEFF Research Database (Denmark)

    Andersen, Lars Bo; Anderssen, Sigmund Alfred; Wisløff, Ulrik;

    2014-01-01

    Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers.......Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers....

  12. Gender, Acculturation, Food Patterns, and Overweight in Korean Immigrants

    Science.gov (United States)

    Jasti, Sunitha; Lee, Chang Hyun; Doak, Colleen

    2011-01-01

    Objective: To describe acculturation, food patterns, overweight, and gender differences among Korean immigrants in the United States. Methods: A cross-sectional exploratory survey assessed acculturation, food frequencies, and weight status of 195 Korean immigrants. Results: Acculturated Korean immigrants (score greater than or equal to] 2.5) were…

  13. Design, Implementation, and Lessons Learned from a Digital Storytelling Project in an Undergraduate Health Promotion Theory Course

    Science.gov (United States)

    Rimando, Marylen; Smalley, K. Bryant; Warren, Jacob C.

    2015-01-01

    This article describes the design, implementation and lessons learned from a digital storytelling project in a health promotion theory course. From 2011-2012, 195 health promotion majors completed a digital storytelling project at a Midwestern university. The instructor observed students' understanding of theories and models. This article adds to…

  14. Which is better for presenting your data: table or graph?

    Institute of Scientific and Technical Information of China (English)

    张莉; 傅小兰

    2004-01-01

    This study aimed at investigating the characteristics of table and graph that people perceive and the data types which people consider the two displays are most appropriate for. Participants in this survey were 195 teachers and undergraduates from four universities in Beijing. The results showed people's different attitudes towards the two forms of display.

  15. Which is better for presenting your data:table or graph?

    Institute of Scientific and Technical Information of China (English)

    张莉; 傅小兰

    2004-01-01

    This study aimed at investigating the characteristics of table and graph that people perceive and the data types which people consider the two displays are most appropriate for. Participants in this survey were 195 teachers and undergraduates from four universities in Beijing. The results showed people's different attitudes towards the two forms of display.

  16. NCBI nr-aa BLAST: CBRC-PHAM-01-0934 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PHAM-01-0934 sp|Q9TV49|CCR5_CERGA RecName: Full=C-C chemokine receptor type 5; Short=C-C CKR-5; Short...=CC-CKR-5; Short=CCR-5; Short=CCR5; AltName: CD_antigen=CD195 gb|AAK43381.1|AF177898_

  17. 21 CFR 131.115 - Concentrated milk.

    Science.gov (United States)

    2010-04-01

    ... be homogenized. (b) Vitamin addition (Optional). If added, vitamin D shall be present in such... used: (1) Carrier for vitamin D. (2) Characterizing flavoring ingredients, with or without coloring, as...) Vitamin D content—“Vitamin D in Milk—Official Final Action,” sections 43.195-43.208. (e) Nomenclature....

  18. Peer Social Skills and Theory of Mind in Children with Autism, Deafness, or Typical Development

    Science.gov (United States)

    Peterson, Candida; Slaughter, Virginia; Moore, Chris; Wellman, Henry M.

    2016-01-01

    Consequences of theory of mind (ToM) development for daily social lives of children are uncertain. Five to 13-year-olds (N = 195) with typical development, autism, or deafness (both native and late signers) took ToM tests and their teachers reported on their social skills for peer interaction (e.g., leadership, group entry). Groups differed in…

  19. X-linked Alport syndrome

    DEFF Research Database (Denmark)

    Jais, J P; Knebelmann, B; Giatras, I;

    2000-01-01

    -linked transmission, were collected. Characteristics of the 401 male patients belonging to the 195 families with COL4A5 mutation are presented. All male patients were hematuric, and the rate of progression to end-stage renal failure and deafness was mutation-dependent. Large deletions, non-sense mutations, or small...

  20. Complete Toluene Oxidation on Pt/CeO2-ZrO2-ZnO Catalysts

    Directory of Open Access Journals (Sweden)

    Nobuhito Imanaka

    2013-08-01

    Full Text Available A 0.4 wt%Pt/Ce0.76Zr0.19Zn0.05O1.95 catalyst was prepared by the evaporative drying method. The catalytic toluene oxidation activity of the catalyst was investigated and the calcination temperature dependence on the toluene oxidation activity was characterized. It was confirmed that only CO2 and steam were produced by the complete oxidation of toluene, and no toluene-derived compounds were detected as by-products with a gas chromatography-mass spectrometer. Toluene was completely oxidized at 320 °C on the 0.4 wt%Pt/Ce0.76Zr0.19Zn0.05O1.95 catalyst calcined at 500 °C. The toluene oxidation activity slightly decreased with increasing the calcination temperature of the catalyst. However, significant deactivation was not recognized in the present 0.4 wt%Pt/Ce0.76Zr0.19Zn0.05O1.95 catalyst, and toluene was completely oxidized at 360 °C even after calcination at 1000 °C. From these results, it became obvious that the 0.4 wt%Pt/Ce0.76Zr0.19Zn0.05O1.95 catalyst has high thermal stability for toluene oxidation activity.

  1. 78 FR 50120 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-08-16

    ... education program upon availability in WebCRD , the central licensing and registration system operated by... 56 Exam and Continuing Education Fees The Exchange proposes to add to its Fee Schedule a $195 fee per... and its related continuing education. However, Members would continue to submit the exam fee to...

  2. Art Therapists and Computer Technology

    Science.gov (United States)

    Peterson, Brent C.; Stovall, Kay; Elkins, David E.; Parker-Bell, Barbara

    2005-01-01

    The purpose of this study was to understand the impact of technology on art therapists by exploring how art therapists own and use technology and to determine barriers to ownership and use. A survey was conducted at the 2002 annual conference of the American Art Therapy Association in Washington, DC. Of the 250 surveys distributed, 195 were…

  3. 75 FR 79709 - Semiannual Regulatory Agenda, Fall 2010

    Science.gov (United States)

    2010-12-20

    ... production and handling of organic agricultural products. Timetable: Action Date FR Cite ANPRM 03/14/08 73 FR... Avian Influenza 195 Handling of Animals; Contingency Plans 0579-AC69 References in boldface appear in... Introduction of Organisms and Products Altered or Produced Through Genetic Engineering 0579-AC31 199...

  4. 78 FR 62012 - Transcontinental Gas Pipeline Company; Notice of Availability of the Draft Environmental Impact...

    Science.gov (United States)

    2013-10-11

    ... compressor station facilities along its existing pipeline system in Pennsylvania and New Jersey to provide...,540 horsepower of compression at its existing Compressor Station 195 in York County, Pennsylvania by replacing three existing natural gas-fired reciprocating engines and appurtenant facilities with two...

  5. The Dissertation Marathon

    Science.gov (United States)

    Black, Ronald

    2012-01-01

    We all think of a marathon as a long-distance running event with an official distance of 42.195 kilometers (26 miles and 385 yards). Throughout time marathon runners have pursued their longest goals by allowing their body to adapt to the new stresses through training. Training for a marathon takes intense preparation, dedication and skill. It is…

  6. 2004 Survey of Adult Protective Services: Abuse of Adults 18 Years of Age and Older

    Science.gov (United States)

    ... for adults 18-59 (21.6%), followed by physical abuse (19.5%), and caregiver neglect/abandonment (18.3%) ( ... third largest category for adults 18-59 was physical abuse (13.2%). Percentages of self-neglect appeared to ...

  7. Kohanenud kirjandus : tänase kirjaniku - ja ka tema lugeja elu sisu määravad majanduslikud argumendid, mitte moraalsed valikud / Kärt Hellerma

    Index Scriptorium Estoniae

    Hellerma, Kärt, 1956-

    2005-01-01

    Arvustus: Delerm, Philippe. Väikesed naudingud. Tallinn : Varrak, 2004 ; Nothomb, Amélie. Jumala lapsepõlv. Tallinn : Varrak, 2004 ; Darrieussecq, Marie. Minu beebi. Tallinn : Varrak, 2005. Ilmunud ka kogumikus: Hellerma, Kärt. Kohanenud kirjandus : valik kirjanduskriitikat 1987-2006. Eesti Keele Sihtasutus : Tallinn, 2006. Lk. 189-195, pealk. Kohanenud kirjandus

  8. Photoionization of Trapped Carriers in Avalanche Photodiodes to Reduce Afterpulsing During Geiger-Mode Photon Counting

    Science.gov (United States)

    Krainak, Michael A.

    2005-01-01

    We reduced the afterpulsing probability by a factor of five in a Geiger-mode photon-counting InGaAs avalanche photodiode by using sub-band-gap (lambda = 1.95 micron) laser diode illumination, which we believe photoionizes the trapped carriers.

  9. File list: Unc.Bld.10.AllAg.Dendritic_Cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Bld.10.AllAg.Dendritic_Cells hg19 Unclassified Blood Dendritic Cells SRX818200,...195,SRX818202,SRX818181,SRX818188,SRX818194,SRX818182 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/Unc.Bld.10.AllAg.Dendritic_Cells.bed ...

  10. Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics.

    Science.gov (United States)

    Ho, Chin Yee; Jaalouk, Diana E; Vartiainen, Maria K; Lammerding, Jan

    2013-05-23

    Laminopathies, caused by mutations in the LMNA gene encoding the nuclear envelope proteins lamins A and C, represent a diverse group of diseases that include Emery-Dreifuss muscular dystrophy (EDMD), dilated cardiomyopathy (DCM), limb-girdle muscular dystrophy, and Hutchison-Gilford progeria syndrome. Most LMNA mutations affect skeletal and cardiac muscle by mechanisms that remain incompletely understood. Loss of structural function and altered interaction of mutant lamins with (tissue-specific) transcription factors have been proposed to explain the tissue-specific phenotypes. Here we report in mice that lamin-A/C-deficient (Lmna(-/-)) and Lmna(N195K/N195K) mutant cells have impaired nuclear translocation and downstream signalling of the mechanosensitive transcription factor megakaryoblastic leukaemia 1 (MKL1), a myocardin family member that is pivotal in cardiac development and function. Altered nucleo-cytoplasmic shuttling of MKL1 was caused by altered actin dynamics in Lmna(-/-) and Lmna(N195K/N195K) mutant cells. Ectopic expression of the nuclear envelope protein emerin, which is mislocalized in Lmna mutant cells and also linked to EDMD and DCM, restored MKL1 nuclear translocation and rescued actin dynamics in mutant cells. These findings present a novel mechanism that could provide insight into the disease aetiology for the cardiac phenotype in many laminopathies, whereby lamin A/C and emerin regulate gene expression through modulation of nuclear and cytoskeletal actin polymerization.

  11. Some Factors Affecting the Job Satisfaction of Academic Women.

    Science.gov (United States)

    Hill, Malcolm D.

    Job satisfaction of 752 male and 195 female faculty in 16 Pennsylvania colleges and unviersities was studied. Job satisfaction was measured by a 45-item inventory, and factor analysis of the inventory revealed the following components of job satisfaction: (1) teaching, (2) recognition-support, (3) convenience, (4) economic, (5) administrative, and…

  12. Class Attendance in College: A Meta-Analytic Review of the Relationship of Class Attendance with Grades and Student Characteristics

    Science.gov (United States)

    Crede, Marcus; Roch, Sylvia G.; Kieszczynka, Urszula M.

    2010-01-01

    A meta-analysis of the relationship between class attendance in college and college grades reveals that attendance has strong relationships with both class grades (k = 69, N = 21,195, p = 0.44) and GPA (k = 33, N = 9,243, p = 0.41). These relationships make class attendance a better predictor of college grades than any other known predictor of…

  13. 33 CFR 117.971 - Neches River.

    Science.gov (United States)

    2010-07-01

    ... infrared “under bridge” presence detector and video cameras reveal nothing under the draw. (b) The draw of... Southern automated bridge, mile 19.5, at Beaumont, is not constantly manned and is operated from a remote site in Shreveport, Louisiana. The bridge is normally maintained in the closed to navigation...

  14. Income inequality and subjective well-being: : A cross-national study on the conditional effects of individual and national characteristics

    NARCIS (Netherlands)

    Rözer, J.J.; Kraaykamp, G.

    2013-01-01

    In this study we raise the question how a nation’s income inequality affects subjective well-being. Using information on 195,091 individuals from 85 different countries from the World Value Surveys and the European Value Surveys, we established that in general, people living in more unequal countrie

  15. Potential bioetanol and biogas production using lignocellulosic biomass from winter rye, oilseed rape and faba bean

    DEFF Research Database (Denmark)

    Petersson, Anneli; Thomsen, Mette Hedegaard; Hauggaard-Nielsen, Henrik;

    2007-01-01

    to be optimal for pretreatment of corn stover (195 degrees C, 15 min, 2 g l(-1) Na2CO3 and 12 bar oxygen). It was shown that pretreatment was necessary for ethanol production from all raw materials and gave increased biogas yield from winter rye straw. Neither biogas productivity nor yield from oilseed rape...

  16. Ethanol production from hydrothermal pretreated corn stover with a loop reactor

    DEFF Research Database (Denmark)

    Xu, Jian; Thomsen, Mette Hedegaard; Thomsen, Anne Belinda

    2010-01-01

    Hydrothermal pretreatment on raw corn stover (RCS) with a loop reactor was investigated at 195 °C for different times varying between 10 min and 30 min. After pretreatment, the slurry was separated into water-insoluble solid (WIS) and liquid phase. Glucan and xylan were found in the both phases...

  17. Children's Perceptions of Maternal Hostility as a Mediator of the Link between Discipline and Children's Adjustment in Four Countries

    Science.gov (United States)

    Lansford, Jennifer E.; Malone, Patrick S.; Dodge, Kenneth A.; Chang, Lei; Chaudhary, Nandita; Tapanya, Sombat; Oburu, Paul; Deater-Deckard, Kirby

    2010-01-01

    Using data from 195 dyads of mothers and children (age range = 8-12 years; M = 10.63) in four countries (China, India, the Philippines, and Thailand), this study examined children's perceptions of maternal hostility as a mediator of the links between physical discipline and harsh verbal discipline and children's adjustment. Both physical…

  18. EST Table: DC551212 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DC551212 E_FL_phe-_24C17_F_0 10/09/28 56 %/189 aa ref|XP_312173.2| AGAP002752-PA [A...nopheles gambiae str. PEST] gb|EAA07879.2| AGAP002752-PA [Anopheles gambiae str. PEST] 10/09/02 52 %/195 aa FBpp012

  19. Fluxes of diatoms in the Dona Paula Bay, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Garg, A.; Bhaskar, P.V.

    . Succession and sedimentation, Mar. Biol., 114, 131–138. Wassmann,P., Vernet,M., Mitchell,B.G. and Rey,F. (1990) Mass sedimentation of Phaeocystis pouchetii in the Barents Sea. Mar. Ecol. Prog. Ser., 66, 183–195. Received on August 24, 1999; accepted...

  20. Pamjat teksta i tekst kak pamjat / Ülle Pärli

    Index Scriptorium Estoniae

    Pärli, Ülle

    1999-01-01

    Bibl. lk. 194. Kokkuvõtted eesti k. "Teksti mälu ja tekst kui mälu" ning inglise k. "The memory of a text and text as a memory", lk. 194-195. Jossif Brodski luuletusest "Järelsõna valmile" ("Posleslovije k basne")

  1. 32 CFR 706.3 - Exemptions by the Secretary of the Navy under Executive Order 11964.

    Science.gov (United States)

    2010-07-01

    ... Collisions at Sea, 1960. Table One Vessel or class USNS HAYES (T-AG-195) T-AGOR 3 Class T-AGS 26 Class T-AOG... Class USS DOLPHIN (AGSS 555) SSN 594 Class SSN 637 Class SSN 688 Class SSBN 726 Class YFU (Ex-LCU...

  2. Trends and developments in two decades of patch testing

    NARCIS (Netherlands)

    Christoffers, W.A.; Schuttelaar, M.-L.A.; Coenraads, P.J.

    2013-01-01

    Introduction: Allergic contact dermatitis is a common condition with an estimated lifetime prevalence of 19.5%. The diagnosis is confirmed by patch tests. This study aims to visualise trends and developments in patch testing over 23 years and to evaluate the influence of legal restrictions with spec

  3. Sintering of Multilayered Porous Structures: Part II – Experiments and Model Applications

    DEFF Research Database (Denmark)

    Ni, De Wei; Olevsky, Eugene; Esposito, Vincenzo;

    2013-01-01

    Experimental analyses of shrinkage and distortion kinetics during sintering of bilayered porous and dense gadolinium-doped ceria Ce0.9Gd0.1O1.95d structures are carried out, and compared with the theoretical models developed in Part I of this work. A novel approach is developed for the determinat...

  4. A higher-level phylogenetic classification of the Fungi

    NARCIS (Netherlands)

    Hibbett, D.S.; Binder, M.; Bischoff, J.F.; Blackwell, M.; Cannon, P.F.; Eriksson, O.E.; Huhndorf, S.; James, T.; Kirk, P.M.; Lücking, R.; Thorsten Lumbsch, H.; Lutzoni, F.; Brandon Matheny, P.; McLaughlin, D.J.; Powell, M.J.; Redhead, S.; Schoch, C.L.; Spatafora, J.W.; Stalpers, J.A.; Vilgalys, R.; Aime, M.C.; Aptroot, A.; Bauer, R.; Begerow, D.; Benny, G.L.; Castlebury, L.A.; Crous, P.W.; Dai, Y.C.; Gams, W.; Geiser, D.M.; Griffith, G.W.; Gueidan, C.; Hawksworth, D.L.; Hestmark, G.; Hosaka, K.; Humber, R.A.; Hyde, K.D.; Ironside, J.E.; Koljalg, U.; Kurtzman, C.P.; Larsson, K.H.; Lichtwardt, R.; Longcore, J.; Miadlikowska, J.; Miller, A.; Moncalvo, J.M.; Mozley-Standridge, S.; Oberwinkler, F.; Parmasto, E.; Reeb, V.; Rogers, J.D.; Roux, Le C.; Ryvarden, L.; Sampaio, J.P.; Schüssler, A.; Sugiyama, J.; Thorn, R.G.; Tibell, L.; Untereiner, W.A.; Walker, C.; Wang, Z.; Weir, A.; Weiss, M.; White, M.M.; Winka, K.; Yao, Y.J.; Zhang, N.

    2007-01-01

    A comprehensive phylogenetic classification of the kingdom Fungi is proposed, with reference to recent molecular phylogenetic analyses, and with input from diverse members of the fungal taxonomic community. The classification includes 195 taxa, down to the level of order, of which 16 are described o

  5. AcEST: DK960660 [AcEST

    Lifescience Database Archive (English)

    Full Text Available sp|Q05BQ1|TUTLA_MOUSE Protein turtle homolog A OS=Mus musculus G... 31 7.1 sp|Q8UGV3|Y932_AGRT5 UPF0260 pro... IS+GG Sbjct: 166 LGTRCVRCEPTFVNTSRSCSCSEPH------ISTGG 195 >sp|Q05BQ1|TUTLA_MOUSE Protein turtle homolog A O

  6. General and Specific Self-Esteem in Late Adolescent Students: Race x Gender x SES Effects.

    Science.gov (United States)

    Richman, Charles L.; And Others

    Self-concept formation has long been considered the most significant developmental milestone of adolescence. To assess the effects of gender, race, and social class on the general and area-specific self-esteem of late adolescents, 195 eleventh grade students, divided according gender, race (black, white), and social class (low, middle, high) were…

  7. Measurement Tools and Target Symptoms/Skills Used to Assess Treatment Response for Individuals with Autism Spectrum Disorder

    Science.gov (United States)

    Bolte, Erin Elizabeth; Diehl, Joshua John

    2013-01-01

    This study examined the measurement tools and target symptoms/skills used to assess treatment response during Autism Spectrum Disorder (ASD) intervention trials from 2001 through 2010. Data from 195 prospective trials were analyzed. There were 289 unique measurement tools, of which 61.6% were used only once, and 20.8 % were investigator-designed.…

  8. Grammar Myths

    Science.gov (United States)

    Berry, Roger

    2015-01-01

    This paper looks at the continued survival of "myths" about English grammar, for example, the statement that in negative and interrogative sentences "any" should be used instead of "some". It is based on a survey of 195 Hong Kong students majoring in English, in five different cohorts, which found that such myths are…

  9. The Self-report Standardized Assessment of Personality-abbreviated Scale: Preliminary results of a brief screening test for personality disorders

    NARCIS (Netherlands)

    Germans, S.; Heck, G.L. van; Moran, P.; Hodiamont, P.P.G.

    2009-01-01

    Objective The internal consistency, test-retest reliability and validity of the Self-report Standardized Assessment of Personality-abbreviated Scale (SAPAS-SR) as a screening instrument for personality disorders were studied in a random sample of 195 Dutch psychiatric outpatients, using the Structu

  10. Small-angle neutron scattering study of the flux-line lattice in a single crystal of Bi2.15Sr1.95CaCu2O8+x

    DEFF Research Database (Denmark)

    Yethiraj, M.; Mook, H.A.; Forgan, E.M.;

    1994-01-01

    A flux‐line lattice (FLL) was observed in a single crystal of Bi2.15Sr1.95CaCu2O8+x (BSCCO) using small‐angle neutron scattering methods. The sample has a superconducting transition at 85 K. The flux‐line lattice is observed to melt, evidenced by the rapid disappearance of diffracted intensity as...

  11. 27 CFR 21.24 - Formula No. 20.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Formula No. 20. 21.24... OF THE TREASURY LIQUORS FORMULAS FOR DENATURED ALCOHOL AND RUM Completely Denatured Alcohol Formulas § 21.24 Formula No. 20. (a) Formula. To every 100 gallons of ethyl alcohol of not less than 195...

  12. Performance of high-resolution X-band radar for rainfall measurement in the Netherlands

    NARCIS (Netherlands)

    Beek, van de C.Z.; Leijnsel, H.; Stricker, J.N.M.; Uijlenhoet, R.; Russchenberg, H.W.J.

    2010-01-01

    This study presents an analysis of 195 rainfall events gathered with the X-band weather radar SOLIDAR and a tipping bucket rain gauge network near Delft, The Netherlands, between May 1993 and April 1994. The aim of this paper is to present a thorough analysis of a climatological dataset using a high

  13. Performance of high-resolution X-band radar for rainfall measurement in The Netherlands

    NARCIS (Netherlands)

    Van de Beek, C.Z.; Leijnse, H.; Stricker, J.N.M.; Uijlenhoet, R.; Russchenberg, H.W.J.

    2010-01-01

    This study presents an analysis of 195 rainfall events gathered with the X-band weather radar SOLIDAR and a tipping bucket rain gauge network near Delft, The Netherlands, between May 1993 and April 1994. The aim of this paper is to present a thorough analysis of a climatological dataset using a high

  14. Elevated skin autofluorescence is strongly associated with foot ulcers in patients with diabetes : a cross-sectional, observational study of Chinese subjects

    NARCIS (Netherlands)

    Hu, Hang; Han, Chun-mao; Hu, Xin-lei; Ye, Wan-lan; Huang, Wen-juan; Smit, Andries J.

    2012-01-01

    This study was designed to evaluate the association between skin autofluorescence (AF), an indicator of advanced glycation end-products (AGEs), and foot ulcers in subjects with diabetes. In this study, 195 Chinese diabetic subjects were examined. Their feet were examined regardless of whether an ulc

  15. Interactions between three subpopulations of Ehrlich ascites tumor and a P388 murine leukemia in mixed solid tumors in immune competent mice

    DEFF Research Database (Denmark)

    Aabo, K; Vindeløv, L L; Christensen, I B;

    1989-01-01

    day 14, tumor growth curves, cell cycle times (per cent labelled mitoses) and cell cycle distributions (flow cytometric DNA analysis). After 2 weeks of growth of mixed P388/E1.95 tumors, flow cytometric DNA analysis on fine-needle tumor aspirates showed nearly total dominance of P388. This type...

  16. Assessing student reflection in medical practice. The development of an observer-rated instrument : reliability, validity and initial experiences

    NARCIS (Netherlands)

    Boenink, AD; Oderwald, AK; de Jonge, P; van Tilburg, W; Smal, JA

    2004-01-01

    INTRODUCTION This study describes the development of an instrument to measure the ability of medical students to reflect on their performance in medical practice. METHODS A total of 195 Year 4 medical students attending a 9-hour clinical ethics course filled in a semi-structured questionnaire consis

  17. A method for distinguishing different water sources during flood events in river floodplains, northern Poland

    NARCIS (Netherlands)

    Chormanski, J.; Karalevich, J.; Kardel, I.; Okruszko, T.; Wassen, M.J.

    2010-01-01

    The Biebrza wetlands are located in an ice-marginal valley in northeastern Poland and cover some 195 000 hectares. The Biebrza river is not regulated, the valley is not reclaimed and still has marsh, fen and grassland vegetation whereas large scale human interventions in hydrology are absent. The mo

  18. The annual terrestrial gamma radiation dose to the population of the urban Christchurch area

    International Nuclear Information System (INIS)

    Natural terrestrial gamma radiation dose rates were measured with a high pressure ionization chamber at 70 indoor (195 site measurements) and 58 outdoor locations in the metropolitan Christchurch area. Based on these site measurements, the average gonad dose rate to the population from natural terrestrial gamma radiation was estimated to be 273+-56 microgray per annum. (auth)

  19. On the Go

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Take a civilized afternoon tea at the Raffles Hotel,Beijing and enjoy unusual cakes and pastries such as Valrhona Chocolate Eclairs and Orange Mousse,all served on a display stand inspired by I93OS architect Lin Huiyin who was the pioneer of afternoon tea in Beijing.Tea costs RMB 195 per stand,plus I5% service.

  20. Typologies of Childhood Exposure to Violence: Associations with College Student Mental Health

    Science.gov (United States)

    Miller-Graff, Laura E.; Howell, Kathryn H.; Martinez-Torteya, Cecilia; Hunter, Erin C.

    2015-01-01

    Objective: This study examined typologies of childhood violence exposure (CVE) and the associations of profiles with current demographic characteristics and mental health in emerging adulthood. Participants: The study evaluated a sample of college students from 2 US geographic regions (Midwest, n = 195; Southeast, n = 200). Methods: An online…

  1. The Struggle Within

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    For Chinalco, the country’s largest aluminum maker, this year’s goal is about revival China Aluminum Corp. (Chinalco) stunned the world with its high- profile $19.5-billion investment plan for Australian mining company Rio Tinto Group. But the aluminum giant’ s financial health may not be as sound as headlines suggest.

  2. China Moves up to Fifth as Importer of Students

    Science.gov (United States)

    Hvistendahl, Mara

    2008-01-01

    According to the Chinese Ministry of Education and the China Scholarship Council, the ministry-directed agency that oversees educational exchange, the number of international students at Chinese universities rose dramatically over the past decade, from 39,000 in 1997 to 195,000 in 2007 (although only one-third of them were seeking degrees). While…

  3. From Somalia to Yemen: great dangers, few prospects

    Directory of Open Access Journals (Sweden)

    Hanno (J H van Gemund

    2007-01-01

    Full Text Available Growing numbers of people are escaping conflict and poverty in Somalia and Ethiopia by making a hazardous journey across the Red Sea. Yemen, their initial destination, has signed the 195 1 Refugee Convention – unlike its Arabian peninsula neighbours – but this poorest of Arab states lacks the means to provide support.

  4. Gclust Server: 199414 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 199414 Vvy_VV1704 Cluster Sequences - 195 hypothetical protein 1 1.00e-99 0.0 0.0 0.0 0.0 3.23 0.0 Show 1994...14 Cluster ID 199414 Sequence ID Vvy_VV1704 Link to cluster sequences Cluster Seque

  5. Retrospective Assessment of Childhood Sexual and Physical Abuse: A Comparison of Scaled and Behaviorally Specific Approaches

    Science.gov (United States)

    DiLillo, David; Fortier, Michelle A.; Hayes, Sarah A.; Trask, Emily; Perry, Andrea R.; Messman-Moore, Terri; Fauchier, Angele; Nash, Cindy

    2006-01-01

    This study compared retrospective reports of childhood sexual and physical abuse as assessed by two measures: the Childhood Trauma Questionnaire (CTQ), which uses a Likert-type scaling approach, and the Computer Assisted Maltreatment Inventory (CAMI), which employs a behaviorally specific means of assessment. Participants included 1,195

  6. CNS histopathology on bovines with clinical suspicion of BSE in Denmark 2001 to 2011

    DEFF Research Database (Denmark)

    Jensen, Tim Kåre

    During2001 to 2011 a total of 195 bovines were submitted to the instutute with clinical suspicion of having BSE. In two cases BSE was confirmed. The most common differential diagnosis was listeriosis, found in 54% of the cases. Listeriosis was characterized by multifocal, necrotizing, non-suppura...

  7. 76 FR 15129 - Temporary Non-Agricultural Employment of H-2B Aliens in the United States

    Science.gov (United States)

    2011-03-18

    .... 1-95, 60 FR 7216, Feb. 7, 1995, which laid out the processing of applications, first at the State... application. ETA issued Training and Employment Guidance Letter (TEGL) No. 21-06, 72 FR 19961, Apr. 20, 2007.... 70 FR 3984, Jan. 27, 2005; 70 FR 3993, Jan. 27, 2005. This set of proposed rules suggested...

  8. Imputating missing values in diary records of sun-exposure study

    DEFF Research Database (Denmark)

    Have, Anna Szynkowiak; Philipsen, Peter Alshede; Larsen, Jan;

    2001-01-01

    In a sun-exposure study, questionnaires concerning sun-habits were collected from 195 subjects. This paper focuses on the general problem of missing data values, which occurs when some, or even all of the questions have not been answered in a questionnaire. Here, only missing values of low...

  9. EST Table: BW999096 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BW999096 SES2266 10/09/28 85 %/193 aa ref|NP_001040402.1| preimplantation protein [...Bombyx mori] gb|ABF51322.1| preimplantation protein [Bombyx mori] 10/08/29 73 %/195 aa FBpp0252287|DwilGK231

  10. Analytical Method Details (MS): SE53_MS02 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available dwell time 0.45 sec; interscan delay 0.05 sec, centroid). The scans were repeated for 19.5 min in a single run. The data were recorded using MassLynx version 4.1 software (Waters). ...

  11. Factors Affecting Willingness to Communicate in a Spanish University Context

    Science.gov (United States)

    Lahuerta, Ana Cristina

    2014-01-01

    The present study examines the relationships among the variables believed to affect Spanish undergraduates' willingness to communicate in English. The participants were 195 students majoring in several degrees at the University of Oviedo. A questionnaire and a standardized English Test were administered to the students in February-March 2013.…

  12. Potential inhibitors from wet oxidation of wheat straw and their effect on growth and ethanol production by Thermoanaerobacter mathranii

    DEFF Research Database (Denmark)

    Klinke, Helene Bendstrup; Thomsen, A.B.; Ahring, Birgitte Kiær

    2001-01-01

    Alkaline wet oxidation (WO) (using water, 6.5 g/l sodium carbonate, and 12 bar oxygen at 195 degreesC) was used for pre-treating wheat straw (60 g/l), resulting in a hemicellulose-rich hydrolysate and a cellulose-rich solid fraction. The hydrolysate consisted of soluble hemicellulose (9 g/l), ali...

  13. Potential inhibitors from wet oxidation of wheat straw and their effect on growth and ethanol production by ¤Thermoanaerobacter mathranii¤

    DEFF Research Database (Denmark)

    Klinke, H.B.; Thomsen, A.B.; Ahring, B.K.

    2001-01-01

    Alkaline wet oxidation (WO) (using water, 6.5 g/l sodium carbonate, and 12 bar oxygen at 195 degreesC) was used for pre-treating wheat straw (60 g/l), resulting in a hemicellulose-rich hydrolysate and a cellulose-rich solid fraction. The hydrolysate consisted of soluble hemicellulose (9 g/l), ali...

  14. Psychosocial Correlates of Insomnia in an Adolescent Population

    Science.gov (United States)

    Siomos, Konstantinos E.; Avagianou, Penelope-Alexia; Floros, Georgios D.; Skenteris, Nikolaos; Mouzas, Odysseas D.; Theodorou, Kyriaki; Angelopoulos, Nikiforos V.

    2010-01-01

    This study examines the nature of the relationship between psychosocial factors and insomnia complaints in an adolescent non-clinical population. It is a cross-sectional study of a stratified sample of 2,195 Greek adolescent high-school students. Subjects were given the Athens insomnia scale, the Symptom Checklist scale (SCL-90-R) and a…

  15. Regulatory Self-efficacy as a Moderator of Peer Socialization Relating to Italian Adolescents' Alcohol Intoxication

    NARCIS (Netherlands)

    Rabaglietti, E.; Burk, W.J.; Giletta, M.

    2012-01-01

    The present study investigated regulatory self-efficacy (RSE) as a predictor of friendship and adolescent alcohol intoxication and as a moderator of peer socialization processes related to alcohol intoxication. The longitudinal sample included 457 Italian adolescents (262 females and 195 males) rang

  16. Complete Genome Sequence of the Highly Virulent Aeromonas schubertii Strain WL1483, Isolated from Diseased Snakehead Fish (Channa argus) in China.

    Science.gov (United States)

    Liu, Lihui; Li, Ningqiu; Zhang, Defeng; Fu, Xiaozhe; Shi, Cunbin; Lin, Qiang; Hao, Guijie

    2016-01-21

    We sequenced the complete genome of the highly virulent Aeromonas schubertii strain WL1483, which was isolated from diseased snakehead fish (Channa argus) in China. The full genome sequence of A. schubertii WL1483 is 4,400,034 bp, which encodes 4,376 proteins and contains 195 predicted RNA genes.

  17. Becoming an Interdisciplinary Scientist: An Analysis of Students' Experiences in Three Computer Science Doctoral Programmes

    Science.gov (United States)

    Calatrava Moreno, María del Carmen; Danowitz, Mary Ann

    2016-01-01

    The aim of this study was to identify how and why doctoral students do interdisciplinary research. A mixed-methods approach utilising bibliometric analysis of the publications of 195 students identified those who had published interdisciplinary research. This objective measurement of the interdisciplinarity, applying the Rao-Stirling index to Web…

  18. 77 FR 59128 - Reporting and Supervision of Inspector General

    Science.gov (United States)

    2012-09-26

    ... supervision of the head of a designated Federal entity, the effect of the changed definition of ``head of the...; Reorganization Plan No. 7 of 1961, 26 FR 7315, August 12, 1961; Pub. L. 89-56, 70 Stat. 195; 5 CFR Part 2638; Pub... 46 CFR Part 501 RIN 3072-AC50 Reporting and Supervision of Inspector General September 20,...

  19. Student-Life Stress in Education and Health Service Majors

    Science.gov (United States)

    Zascavage, Victoria; Winterman, Kathleen G.; Buot, Max; Wies, Jennifer R.; Lyzinski, Natalie

    2012-01-01

    In order to better understand the effects of student-life stress on Education and Health Service majors (n = 195) at a private, religious, Midwestern university in the USA, we assessed student perception of overall stress level and physical stress level using the Student-life Stress Inventory. The targeted sample consisted of students with…

  20. 30 CFR 57.5015 - Oxygen deficiency.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Oxygen deficiency. 57.5015 Section 57.5015..., Physical Agents, and Diesel Particulate Matter Air Quality-Underground Only § 57.5015 Oxygen deficiency. Air in all active workings shall contain at least 19.5 volume percent oxygen....

  1. EST Table: CK545651 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK545651 rswhb0_016557.y1 10/09/29 43 %/195 aa ref|XP_002426374.1| pnuts protein, p...utative [Pediculus humanus corporis] gb|EEB13636.1| pnuts protein, putative [Pediculus humanus corporis] 10/

  2. EST Table: CK541931 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK541931 rswhb0_006075.y1 10/09/29 35 %/195 aa ref|XP_001861779.1| pnuts protein [C...ulex quinquefasciatus] gb|EDS36099.1| pnuts protein [Culex quinquefasciatus] 10/08/31 33 %/230 aa FBpp011826

  3. Main: ABRELATERD1 [PLACE

    Lifescience Database Archive (English)

    Full Text Available ABRELATERD1 S000414 01-August-2006 (last modified) kehi ABRE-like sequence (from -1...99 to -195) required for etiolation-induced expression of erd1 (early responsive to dehydration) in Arabidopsis; ABRE; etiolation; erd; Arabidopsis thaliana ACGTG ...

  4. Incidence rates and management of urinary tract infections among children in Dutch general practice: results from a nation-wide registration study.

    NARCIS (Netherlands)

    W.Y. Kwok (Wing-Yee); M.C. Kwaadsteniet (Marjolein); M. Harmsen (Mirjam); L.W.A. van Suijlekom-Smit (Lisette); F.G. Schellevis (François); J.C. van der Wouden (Hans)

    2006-01-01

    textabstractBACKGROUND: We aimed to investigate incidence rates of urinary tract infections in Dutch general practice and their association with gender, season and urbanisation level, and to analyse prescription and referral in case of urinary tract infections. METHOD: During one calendar year, 195

  5. Incidence rates and management of urinary tract infections among children in Dutch general practice: results from a nation-wide registration study.

    NARCIS (Netherlands)

    Kwok, W.Y.; Kwaadsteniet, M.C.E. de; Harmsen, M.; Suijlekom-Smit, L.W.A. van; Schellevis, F.G.; Wouden, J.C. van der

    2006-01-01

    Background: We aimed to investigate incidence rates of urinary tract infections in Dutch general practice and their association with gender, season and urbanisation level, and to analyse prescription and referral in case of urinary tract infections. Method: During one calendar year, 195 general prac

  6. Incidence rates and management of urinary tract infections among children in Dutch general practice: results from a nation-wide registration study.

    NARCIS (Netherlands)

    Kwok, W.Y.; Kwaadsteniet, M.C. de; Harmsen, M.; Suijlekom-Smit, L.W. van; Schellevis, F.G.; Wouden, J.C. van der

    2006-01-01

    BACKGROUND: We aimed to investigate incidence rates of urinary tract infections in Dutch general practice and their association with gender, season and urbanisation level, and to analyse prescription and referral in case of urinary tract infections. METHOD: During one calendar year, 195 general prac

  7. Occurrence of aflatoxins and aflatoxin-producing Aspergillus spp. associated with groundnut production in subsistence farming systems in South Africa

    NARCIS (Netherlands)

    Ncube, E.; Flett, B.C.; Waalwijk, C.; Viljoen, A.

    2010-01-01

    Abstract: Author: Ncube, E. Flett, B.C. Waalwijk, C. Viljoen, A. Vol 27 Issue 2 Publication: 2010 Page: 195-198 : Aflatoxins are carcinogenic mycotoxins produced by Aspergillus spp. in groundnut kernels. Forty-six groundnut samples were collected from subsistence farmers in three provinces of South

  8. Determination of activation level energy of nuclear isomers by calibration of microspectra of radioactive sources

    International Nuclear Information System (INIS)

    Nuclear isomers with unknown activation level were irradiated by calibrated radioactive sources. The integral cross sections were calculated for different energies of the sources. The activation energy was given by values coinciding with each other within the limits of error. The method made the determination of the unknown level of 1180+-10 keV of 195Pt nucleus possible. (author)

  9. Editorial; Lipids in Metabolic Health and Disease

    NARCIS (Netherlands)

    Glatz, Jan; De Groot, Renate; Hesselink, Matthijs; Schrauwen, Patrick

    2012-01-01

    Glatz, J. F. C., De Groot, R. H. M., Hesselink, K. C., & Schrauwen, P. (2011). Editorial; Lipids in Metabolic Health and Disease. Prostaglandines, Leukotrienes and Essential fatty Acids, 85, 195. DOI: 10.1016/j.plefa.2011.04.006

  10. USE OF BLOOD PRODUCTS FOR ELECTIVE SURGERY IN 43 EUROPEAN HOSPITALS

    NARCIS (Netherlands)

    SIRCHIA, G; GIOVANETTI, AM; BAELE, PL; DACOSTA, RBC; DROUET, N; TENDUIS, HJ; JOERGENSEN, J; MANIATIS, A; MCCLELLAND, B; MESSMER, KFW; CASTEL, AN; SISSOURAS, AA; MILANI, S; PAPPALETTERA, M

    1994-01-01

    The objective of this study was to assess the use of blood products and artificial colloids in six commonly performed elective surgical procedures in 43 teaching hospitals in 10 European countries. 7,195 patient data were analysed. For each product wide differences were found between hospitals, both

  11. A multidisciplinary approach to study virulence of the entomopathogenic fungus Beauveria bassiana towards malaria mosquitoes

    NARCIS (Netherlands)

    Valero Jimenez, C.A.

    2016-01-01

    1.95pt;">Although globally malaria mortality rates have fallen by 48% between 2000 and 2015, malaria is still killing an estimated 438,000 people each year. An effective way to alleviate the burden of malaria is to control its vector (malaria mosquitoes) using insecticides. Th

  12. Highly efficient Gd, Lu co-doped KY(WO4)2:Yb3+ planar waveguide laser

    NARCIS (Netherlands)

    Geskus, Dimitri; Aravazhi, Shanmugam; Bernhardi, Edward; Grivas, Christos; Wörhoff, Kerstin; Pollnau, Markus

    2009-01-01

    Laser operation at 1025 nm with 82.3% slope efficiency and 195 mW output power for 23% outcoupling is reported for KY(WO4)2:Yb3+ planar waveguides, co-doped with optically inert Gd3+ and Lu3+ ions. Codoping enhances the refractive index contrast, improves light confinement, and reduces the threshold

  13. China's Energy Demand Growth Expected to Slow Down in 2005

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ China's energy consumption rises 15.1 percent China's energy consumption rose 15.1 percent in the first 11 months of 2004, boosted by strong demand from manufacturing industries, according to the reports from the Chinese news media. In the period from January to November, the country consumed a total of 1.95 trillion kilowatt hours.

  14. 75 FR 35366 - Pipeline Safety: Applying Safety Regulation to All Rural Onshore Hazardous Liquid Low-Stress Lines

    Science.gov (United States)

    2010-06-22

    ... potential environmental damage a release from these lines could pose, in 2006, PHMSA issued a NPRM (71 FR... of proposed rulemaking (SNPRM) (72 FR 28008) that proposed to apply all Part 195 requirements to any... two. PHMSA published the final rule on June 3, 2008 (73 FR 31634), which finalized the...

  15. Testicular Self-Examination: A Test of the Health Belief Model and the Theory of Planned Behaviour

    Science.gov (United States)

    McClenahan, Carol; Shevlin, Mark; Adamson, Gary; Bennett, Cara; O'Neill, Brenda

    2007-01-01

    The aim of this study was to test the utility and efficiency of the theory of planned behaviour (TPB) and the health belief model (HBM) in predicting testicular self-examination (TSE) behaviour. A questionnaire was administered to an opportunistic sample of 195 undergraduates aged 18-39 years. Structural equation modelling indicated that, on the…

  16. 78 FR 28244 - Agency Information Collection Activities; Proposed Collection; Comment Request

    Science.gov (United States)

    2013-05-14

    ... NRC to meet its responsibilities to conduct a detailed review of applications for licenses and... communications. 5. The number of annual respondents: 251. 6. The number of hours needed annually to complete the... recordkeeping (an average of 19.5K hrs/ recordkeeper). 7. Abstract: Part 50 of Title 10 of the Code of...

  17. Loneliness and Shyness in Adolescent Problematic Internet Users: The Role of Social Anxiety

    Science.gov (United States)

    Huan, Vivien S.; Ang, Rebecca P.; Chye, Stefanie

    2014-01-01

    Background: Davis' ("Comput Hum Behav" 17:187-195, 2001) cognitive-behavioral model of problematic Internet use (PIU) proposed and theorized that certain psychopathological characteristics present within an individual, predispose him to PIU. Objective: This study extended Davis' model in hypothesizing that social anxiety…

  18. EST Table: FS904069 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS904069 E_FL_ftes_53L19_R_0 10/09/28 42 %/195 aa ref|NP_001036933.1| molting fluid... carboxypeptidase A [Bombyx mori] dbj|BAD60916.1| molting fluid carboxypeptidase A [Bombyx mori] 10/09/12 38

  19. Part I: Study on investment protection agreements as instruments of international economic law

    NARCIS (Netherlands)

    P.J. Kuijper

    2014-01-01

    This study seeks to set out briefly the historical background and the development of present-day Bilateral Investment Treaties (BITs) that have grown in sophistication and in number since the first one of this type of treaties was concluded between the Federal Republic of Germany and Pakistan in 195

  20. 75 FR 27580 - Notice of Lodging of the Consent Decree Under the Clean Water Act

    Science.gov (United States)

    2010-05-17

    ..., a proposed Consent Decree in United States v. Puerto Rico Aqueduct and Sewer Authority (``PRASA... with the Surface Water Treatment Rule (``SWTR''), at three Water Treatment Plants (``WTPs'') owned and... treatment plant improvement projects over the next 15 years valued at $195 million. These projects...