Sample records for astatine 194

  1. Astatine-211: production and availability. (United States)

    Zalutsky, Michael R; Pruszynski, Marek


    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production.

  2. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A


    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  3. Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Jakobsson, U., E-mail:; Cederwall, B. [KTH, The Division of Nuclear Physics, AlbaNova University Center, SE-10691 Stockholm (Sweden); Uusitalo, J.; Auranen, K.; Badran, H.; Cox, D. M.; Grahn, T.; Greenlees, P. T.; Julin, R.; Juutinen, S.; Herzáň, A.; Konki, J.; Leino, M.; Mallaburn, M.; Pakarinen, J.; Papadakis, P.; Partanen, J.; Rahkila, P.; Sandzelius, M.; Sarén, J. [University of Jyvaskyla, Department of Physics, P.O. Box 35, FI-40014 University of Jyvaskyla (Finland); and others


    Low-lying states in neutron-deficient astatine and francium nuclei have been studied by means of in-beam and delayed spectroscopy. The 13/2{sup +} state has been observed in francium nuclei with a similar down-sloping trend as in neighbouring astatine and bismuth isotopes, as a function of decreasing neutron number. A systematic trend can also now be seen for the 1/2{sup +} state both in astatine and francium nuclei, where the level energy decreases steeply as a function of neutron number when moving further away from the neutron shell closure. This trend is very similar between astatine nuclei and their francium isotones. Moreover, shape coexistence has been observed between the 13/2{sup +} state and the spherical 9/2{sup −} ground state in {sup 203}Fr and {sup 205}Fr.

  4. The {sup 194}Os/{sup 194}Ir generator: Production and purification of {sup 194}Os

    Energy Technology Data Exchange (ETDEWEB)

    Mirzadeh, S.; Rice, D.E.; Callahan, A.P.; Knapp, F.F. Jr.


    Iridium-194 (t{sub {1/2}} = 19.15 h) decays by {beta}-particle emission (E{sub {beta}}{sup max} = 2.236 MeV) and is a potential candidate for radioimmunotherapy [1,2]. An important characteristic is availability of carrier-free {sup 194}Ir from {beta}-decay of {sup 194}Os (t{sub {1/2}} = 6 y). The {sup 194}Os parent nuclei is produced in a fission nuclear reactor with double neutron capture on {sup 192}Os (41.0% natural abundance). We report here the preliminary nuclear data for production of {sup 194}OS and discuss the feasibility of producing sufficient quantities of {sup 194}Os required for the fabrication of the large-scale generators for further studies. In addition, we describe a novel gas- thermochromatographic method (GTC) for the one step conversion of metallic Os to OsO{sub 4} and subsequent separation and purification of OsO{sub 4}. 6 refs., 1 fig., 1 tab.

  5. The sup 194 Os/ sup 194 Ir generator: Production and purification of sup 194 Os

    Energy Technology Data Exchange (ETDEWEB)

    Mirzadeh, S.; Rice, D.E.; Callahan, A.P.; Knapp, F.F. Jr.


    Iridium-194 (t{sub {1/2}} = 19.15 h) decays by {beta}-particle emission (E{sub {beta}}{sup max} = 2.236 MeV) and is a potential candidate for radioimmunotherapy (1,2). An important characteristic is availability of carrier-free {sup 194}Ir from {beta}-decay of {sup 194}Os (t{sub {1/2}} = 6 y). The {sup 194}Os parent nuclei is produced in a fission nuclear reactor with double neutron capture on {sup 192}Os (41.0% natural abundance). We report here the preliminary nuclear data for production of {sup 194}OS and discuss the feasibility of producing sufficient quantities of {sup 194}Os required for the fabrication of the large-scale generators for further studies. In addition, we describe a novel gas- thermochromatographic method (GTC) for the one step conversion of metallic Os to OsO{sub 4} and subsequent separation and purification of OsO{sub 4}. 6 refs., 1 fig., 1 tab.

  6. 40 CFR 194.27 - Peer review. (United States)


    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Peer review. 194.27 Section 194.27... § 194.27 Peer review. (a) Any compliance application shall include documentation of peer review that has... barrier evaluation as required in § 194.44. (b) Peer review processes required in paragraph (a) of...

  7. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom


    and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting......To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...

  8. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    NARCIS (Netherlands)

    Rothe, S.; Andreyev, A. N.; Antalic, S.; Borschevsky, A.; Capponi, L.; Cocolios, T. E.; De Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.; Kaldor, U.; Kudryavtsev, Yuri; Koester, U.; Lane, J. F. W.; Lassen, J.; Liberati, V.; Lynch, K. M.; Marsh, B. A.; Nishio, K.; Pauwels, D.; Pershina, V.; Popescu, L.; Procter, T. J.; Radulov, D.; Raeder, S.; Rajabali, M. M.; Rapisarda, E.; Rossel, R. E.; Sandhu, K.; Seliverstov, M. D.; Sjoedin, A. M.; Van den Bergh, P.; Van Duppen, P.; Venhart, M.; Wakabayashi, Y.; Wendt, K. D. A.


    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviou

  9. 40 CFR 194.22 - Quality assurance. (United States)


    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Quality assurance. 194.22 Section 194... General Requirements § 194.22 Quality assurance. (a)(1) As soon as practicable after April 9, 1996, the Department shall adhere to a quality assurance program that implements the requirements of ASME...

  10. 46 CFR 194.15-1 - General. (United States)


    ... EXPLOSIVES AND OTHER HAZARDOUS MATERIALS Chemistry Laboratory and Scientific Laboratory § 194.15-1 General... 46 Shipping 7 2010-10-01 2010-10-01 false General. 194.15-1 Section 194.15-1 Shipping COAST GUARD... subject to the applicable requirements of § 190.07-10(d). (1) Incombustible materials shall be...

  11. 40 CFR 194.24 - Waste characterization. (United States)


    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Waste characterization. 194.24 Section 194.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION... General Requirements § 194.24 Waste characterization. (a) Any compliance application shall describe...

  12. 49 CFR 194.117 - Training. (United States)


    ... 49 Transportation 3 2010-10-01 2010-10-01 false Training. 194.117 Section 194.117 Transportation... Response Plans § 194.117 Training. (a) Each operator shall conduct training to ensure that: (1) All... of equipment, fire suits, and breathing apparatus. (b) Each operator shall maintain a training...

  13. Dicty_cDB: SLA194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLA194 (Link to dictyBase) - - - Contig-U16368-1 SLA194Z (Link... to Original site) - - SLA194Z 528 - - - - Show SLA194 Library SL (Link to library) Clone ID SLA194 (Link Representative seq. ID SLA19...4Z (Link to Original site) Representative DNA sequence >SLA194 (SLA194Q) /CSM/SL/SLA1-D/SLA194Q.Seq.d/ XXXXX...CAAGCTCAGAAAGCTCAGAAAGCTCATCAGCCACTTCATAAATAAAACTTTGATC sequence update 1997. 5.16 Translated Amino Acid seq

  14. Dicty_cDB: SLC194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLC194 (Link to dictyBase) - - - - SLC194Z (Link to Original site) - - SLC...194Z 699 - - - - Show SLC194 Library SL (Link to library) Clone ID SLC194 (Link to dictyBase) At...las ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL Representative seq. ID SLC194Z (Link to Original site) R...epresentative DNA sequence >SLC194 (SLC194Q) /CSM/SL/SLC1-D/SLC194Q.Seq.d/ XXXXXXXXXXTTATGAAGGTGAACGTGCTATGA

  15. 46 CFR 194.15-19 - Electrical. (United States)


    ... 46 Shipping 7 2010-10-01 2010-10-01 false Electrical. 194.15-19 Section 194.15-19 Shipping COAST....15-19 Electrical. (a) All electrical equipment located within 18 inches of the deck of the chemical laboratory shall be in accordance with the applicable requirements of Subchapter J (Electrical...

  16. 21 CFR 211.194 - Laboratory records. (United States)


    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Laboratory records. 211.194 Section 211.194 Food... Laboratory records. (a) Laboratory records shall include complete data derived from all tests necessary to..., including all graphs, charts, and spectra from laboratory instrumentation, properly identified to show...

  17. Dicty_cDB: AFM194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AF (Link to library) AFM194 (Link to dictyBase) - - - - AFM194P (Link to Original site) AFM194F 623 AFM...194Z 703 AFM194P 1306 - - Show AFM194 Library AF (Link to library) Clone ID AFM194 (Link... to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL Representative seq. ID AFM194P (Link to... Original site) Representative DNA sequence >AFM194 (AFM194Q) /CSM/AF/AFM1-D/AFM194Q.Seq.d/ ATTTTATAATCACTGT

  18. 46 CFR 194.15-5 - Ventilation. (United States)


    ... CONTROL OF EXPLOSIVES AND OTHER HAZARDOUS MATERIALS Chemistry Laboratory and Scientific Laboratory § 194... emergencies. The system shall have a capacity sufficient to effect a complete change of air in not more than...

  19. Dicty_cDB: SLE194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLE194 (Link to dictyBase) - - - Contig-U16510-1 SLE194Z (Link... to Original site) - - SLE194Z 495 - - - - Show SLE194 Library SL (Link to library) Clone ID SLE194 (Link Representative seq. ID SLE19...4Z (Link to Original site) Representative DNA sequence >SLE194 (SLE194Q) /CSM/SL/SLE1-D/SLE194Q.Seq.d/ XXXXX...kk*y*kspfylynf*ikykin Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SLE194 (SLE

  20. Dicty_cDB: SSD194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available cds; BC1 scRNA gene, complete sequence; hypothetical protein and cyclin D1 (Ccnd1...SS (Link to library) SSD194 (Link to dictyBase) - - - Contig-U13941-1 SSD194P (Link to Original site) SSD1...94F 634 SSD194Z 702 SSD194P 1336 - - Show SSD194 Library SS (Link to library) Clone ID SSD1...e URL Representative seq. ID SSD1...94P (Link to Original site) Representative DNA sequence >SSD194 (SSD194Q) /CSM/SS/SSD1-D/SSD1

  1. Dicty_cDB: CHS194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHS194 (Link to dictyBase) - - - Contig-U11696-1 - (Link to Original site) CHS1...94F 159 - - - - - - Show CHS194 Library CH (Link to library) Clone ID CHS194 (Link to Representative seq. ID - (Link to ...Original site) Representative DNA sequence >CHS194 (CHS194Q) /CSM/CH/CHS1-D/CHS194Q.Seq.d/ ATAATTATAAAAATTAC...omology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value CHS194 (CHS194Q) /CSM/CH/CHS1-D/CHS1

  2. Dicty_cDB: CHR194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHR194 (Link to dictyBase) - - - Contig-U16433-1 CHR194P (Link to Original site) CHR...194F 144 CHR194Z 570 CHR194P 694 - - Show CHR194 Library CH (Link to library) Clone ID CHR... URL Representative seq. ID CHR...194P (Link to Original site) Representative DNA sequence >CHR194 (CHR194Q) /CSM/CH/CHR1-D/CHR1...A sequence from clone RP11-475L16 on chromosome 10. 48 0.25 1 CR940353 |CR940353.

  3. Anämien bei 194 Katzen


    Merten, Nina


    Anemia is a common alteration of the hemogram in cats. To date there are only few studies on the prevalence and frequency of the different types of anemia in feline patients. The objective of this prospective study was to describe the medical reports of anemia in 194 cats with a hematocrit


    NARCIS (Netherlands)



    Lifetimes of members of the superdeformed band in 194Pb were measured by the Doppler-shift attenuation method. Quadrupole moments around 20 eb that are constant over the whole frequency range were derived. The results rule out large centrifugal stretching effects.

  5. Laser photodetachment of radioactive ions: towards the determination of the electronegativity of astatine

    CERN Multimedia

    Rothe, Sebastian; Welander, Jakob Emanuel; Chrysalidis, Katerina; Day Goodacre, Thomas; Fedosseev, Valentine; Fiotakis, Spyridon; Forstner, Oliver; Heinke, Reinhard Matthias; Johnston, Karl; Kron, Tobias; Koester, Ulli; Liu, Yuan; Marsh, Bruce; Ringvall Moberg, Annie; Rossel, Ralf Erik; Seiffert, Christoph; Studer, Dominik; Wendt, Klaus; Hanstorp, Dag


    Negatively charged ions are mainly stabilized through the electron correlation effect. A measure of the stability of a negative ion is the electron affinity, which the energy gain by attaching an electron to a neutral atom. This fundamental quantity is, due to the almost general lack of bound excited states, the only atomic property that can be determined with high accuracy for negative ions. We will present the results of the first laser photodetachment studies of radioactive negative ions at CERN-ISOLDE. The photodetachment threshold for the radiogenic iodine isotope 128I was measured successfully, demonstrating the performance of the upgraded GANDALPH experimental beam line. The first detection of photo-detached astatine atoms marks a milestone towards the determination of the EA of this radioactive element.

  6. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron affinity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photo-detachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral line width of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in off-line tests by the clear observation of the photo-detachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148.

  7. 34 CFR 300.194 - Show cause hearing. (United States)


    ... 34 Education 2 2010-07-01 2010-07-01 false Show cause hearing. 300.194 Section 300.194 Education... DISABILITIES State Eligibility By-Pass for Children in Private Schools § 300.194 Show cause hearing. (a) If a show cause hearing is requested, the Secretary— (1) Notifies the SEA and affected LEA or other...

  8. 40 CFR 194.46 - Removal of waste. (United States)


    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Removal of waste. 194.46 Section 194... PROGRAMS CRITERIA FOR THE CERTIFICATION AND RE-CERTIFICATION OF THE WASTE ISOLATION PILOT PLANT'S... Assurance Requirements § 194.46 Removal of waste. Any compliance application shall include...

  9. 46 CFR 194.20-19 - Piping and electrical requirements. (United States)


    ... 46 Shipping 7 2010-10-01 2010-10-01 false Piping and electrical requirements. 194.20-19 Section 194.20-19 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH... Storerooms § 194.20-19 Piping and electrical requirements. (a) Piping, electrical equipment, and wiring...

  10. Ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and ionic radii of element Uus (Z = 117) and astatine. (United States)

    Chang, Zhiwei; Li, Jiguang; Dong, Chenzhong


    Multiconfiguration Dirac-Fock (MCDF) method was employed to calculate the first five ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and radii for the element Uus and its homologue At. Main valence correlation effects were taken into account. The Breit interaction and QED effects were also estimated. The uncertainties of calculated IPs, EAs, and IR for Uus and At were reduced through an extrapolation procedure. The good consistency with available experimental and other theoretical values demonstrates the validity of the present results. These theoretical data therefore can be used to predict some unknown physicochemical properties of element Uus, Astatine, and their compounds.

  11. 28 CFR 19.4 - Cost and percentage estimates. (United States)


    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Cost and percentage estimates. 19.4... RECOVERY OF MISSING CHILDREN § 19.4 Cost and percentage estimates. It is estimated that this program will cost DOJ $78,000 during the initial year. This figure is based on estimates of printing, inserting,...

  12. 13 CFR 120.194 - Use of computer forms. (United States)


    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Use of computer forms. 120.194... Applying to All Business Loans Computerized Sba Forms § 120.194 Use of computer forms. Any Applicant or Participant may use computer generated SBA application forms, closing forms, and other forms designated by...

  13. 46 CFR 194.05-3 - Chemical stores. (United States)


    ... shall be classed, marked and labeled in accordance with 49 CFR part 172: (1) Explosives. (2) Flammable... under paragraph (a) of this section but not specifically listed by name in 49 CFR 172.101 must be... 46 Shipping 7 2010-10-01 2010-10-01 false Chemical stores. 194.05-3 Section 194.05-3...

  14. 40 CFR 194.23 - Models and computer codes. (United States)


    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Models and computer codes. 194.23... General Requirements § 194.23 Models and computer codes. (a) Any compliance application shall include: (1... obtain stable solutions; (iv) Computer models accurately implement the numerical models; i.e.,...

  15. 46 CFR 194.10-20 - Magazine chest construction. (United States)


    ... 46 Shipping 7 2010-10-01 2010-10-01 false Magazine chest construction. 194.10-20 Section 194.10-20... construction. (a) Magazine chests shall be of watertight metal construction with flush interior. The body and...) Chests shall be secured to the vessel's structure by means of permanently installed foundation clips...


    Energy Technology Data Exchange (ETDEWEB)



    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  17. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  18. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian


    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  19. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina


    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  20. Studies of {sup 194,195,197}Po

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, M.P.; Ahmad, I.; Crowell, B. [and others


    The energy systematics of low-lying polonium states show sudden changes near N = 114. The observed drops in the low-lying levels of {sup 196,198}Po relative to the heavier isotopes indicate significant changes in the underlying structure of these nuclei. It is thought that this change is due to the onset of vibrational collectivity brought about by the quadrupole interaction between neutron and proton-pairs. In order to extend the Po systematics even further, we measured, for the first time, states in {sup 194,195,197}Po using the {sup 28}Si + {sup 170}Yb reaction at a beam energy of 142 MeV. The beam was supplied by ATLAS, and the data were taken with 10 Compton-suppressed Ge detectors placed at the target position of the Fragment Mass Analyzer. Preliminary level schemes were constructed for {sup 194,195,197}Po based on {gamma}-{gamma} and {gamma}-FMA coincidences. The results for {sup 194}Po show that the 2{sup +} - 0{sup +} transition energy decreased in energy by 140 keV relative to {sup 196}Po suggesting that this nucleus moved beyond the vibrational limit to more collective motion. An extrapolation of the systematics predicts that the 2{sup +} energy could drop another 140 keV between {sup 194}Po and {sup 192}Po which would indicate the onset of rotational motion. Currently, we have an approved experiment to investigate the decay of yrast isomers in {sup 194}Po which will allow us to (1) confirm our earlier level scheme of {sup 194}Po, and (2) assess the experimental conditions needed for a future study of {sup 192}Po.

  1. Identical Bands and Alignment in 193,194Tl

    Institute of Scientific and Technical Information of China (English)

    HE Xiao-Tao; YU Shao-Ying; LIU Shu-Xin; LIU Yan-Xin; ZHAO En-Guang


    @@ The microscopic mechanism of the identical bands in odd odd nucleus 194Tl and its neighbour odd-A nucleus 193Tl are investigated using the particle-number conserving method with monopole and quadrupole pairing interaction.It is found that the blocking effect plays an important role in the variation of moments of inertia (J(1) and J(2))with rotational frequency for the superdeformed bands and identical bands. The alignment of 194Tl bands with respect to the 193 Tl(1) band used as a reference is also discussed.

  2. Rotational bands and chirality in {sup 194}Tl

    Energy Technology Data Exchange (ETDEWEB)

    Masiteng, P.L. [National Research Foundation, iThemba LABS, P.O. Box 722, Somerset West (South Africa); University of the Western Cape, Bellville (South Africa); University of Johannesburg, P.O. Box 524, Auckland Park (South Africa); Lawrie, E.A.; Lawrie, J.J.; Bark, R.A.; Mullins, S.M.; Murray, S.H.T. [National Research Foundation, iThemba LABS, P.O. Box 722, Somerset West (South Africa); Ramashidzha, T.M.; Maine, P.; Maliage, S.M.; Sharpey-Schafer, J.F.; Shirinda, O.; Vymers, P.A. [National Research Foundation, iThemba LABS, P.O. Box 722, Somerset West (South Africa); University of the Western Cape, Bellville (South Africa); Lindsay, R. [University of the Western Cape, Bellville (South Africa); Komati, F.; Kau, J. [National Research Foundation, iThemba LABS, P.O. Box 722, Somerset West (South Africa); University of North West, Mmabatho (South Africa); Matamba, I. [University of Venda for Science and Technology, Thohoyandou (South Africa); Mutshena, K.P. [National Research Foundation, iThemba LABS, P.O. Box 722, Somerset West (South Africa); University of Venda for Science and Technology, Thohoyandou (South Africa); Pasternak, A.A. [A.F. Ioffe Physical-Technical Institute, St.-Petersburg (Russian Federation); Roux, D.G. [University of the Western Cape, Bellville (South Africa); Rhodes University, P.O. Box 94, Grahamstown (South Africa)


    The high-spin states in {sup 194}Tl were studied using the {sup 181}Ta({sup 18}O, 5n) reaction and the AFRODITE γ -ray spectrometer at iThemba LABS. The level scheme of {sup 194}Tl was considerably extended with several new bands. Three negative-parity 4-quasiparticle bands were observed and associated with πh{sub 9/2} x νi{sub 13/2}{sup -3} configurations. Two of these form a candidate chiral pair with excellent near-degeneracy. In addition two new positive-parity bands were found. (orig.)

  3. 40 CFR 194.51 - Consideration of protected individual. (United States)


    ... COMPLIANCE WITH THE 40 CFR PART 191 DISPOSAL REGULATIONS Compliance Certification and Re-certification Individual and Ground-Water Protection Requirements § 194.51 Consideration of protected individual... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Consideration of protected...

  4. Phenotype-gene: 194 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available uence of brassinosteroid for AT1G12840 ... decreased sensitivity toward under influence... 194 decreased sensitivity toward under infl

  5. Decay from the superdeformed bands in {sup 194}Hg

    Energy Technology Data Exchange (ETDEWEB)

    Henry, R.G.; Khoo, T.L.; Carpenter, M.P. [and others


    Superdeformed bands in {sup 194}H g were studied using the early implementation of Gammasphere. The response functions for the Ge detectors were measured for the first time as part of this experiment. Experiments were performed with both a backed target (where the residue stopped in the Au backing) and a thin target (where the residue recoiled into vacuum). This will permit measurements of the decay times of the quasicontinuum {gamma}rays. The spectrum in coincidence with the yrast SD band in {sup 194}Hg reveals the same features as found in the quasicontinuum structure in {sup 192}Hg. These features include: statistical {gamma}rays feeding the SD band, a pronounced E2 peak from transitions feeding the SD band, a Ml/E2 bump at low energies that is associated with the last stages of feeding of the superdeformed band, and a quasicontinuous distribution from {gamma}rays linking SD and normal states, including a sizable clustering of strength around 1.7 MeV. The remarkable similarity of the spectra coincident with SD bands in {sup 192,194}Hg provides additional support for a statistical process for decay out of the SD states. This similarity contrasts with differences observed in the spectrum coincident with the SD band in the odd-even {sup 191}Hg, confirming the predictions about the role of pairing (in normal states) in influencing the shape of the decay-out spectrum.

  6. MicroRNA-194 promotes osteoblast differentiation via downregulating STAT1

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jun [Department of Emergency, Shannxi Province People' s Hospital, Third Affiliated Hospital of Xi' an Jiaotong University, Xi' an 710052 (China); He, Xijing [Department of Orthopaedics, Second Affiliated Hospital of Xi' an Jiaotong University, Xi' an 710004 (China); Wei, Wenzhi [Department of Emergency, Shannxi Province People' s Hospital, Third Affiliated Hospital of Xi' an Jiaotong University, Xi' an 710052 (China); Zhou, Xiaobo, E-mail: [Department of Immunology and Pathogenic Biology, Medical School, Xi' an Jiaotong University, Xi' an 710061 (China)


    Osteoblast differentiation is a vital process in maintaining bone homeostasis in which various transcriptional factors, signaling molecules, and microRNAs (miRNAs) are involved. Recently, signal transducer and activator of transcription 1 (STAT1) has been found to play an important role in regulating osteoblast differentiation. Here, we identified that STAT1 expression was regulated by miR-194. Using mouse bone mesenchymal stem cells (BMSCs), we found that miR-194 expression was significantly increased following osteoblast differentiation induction. Overexpression of miR-194 by lentivirus-mediated gene transfer markedly increased osteoblast differentiation, whereas inhibition of miR-194 significantly suppressed osteoblast differentiation of BMSCs. Using a dual-luciferase reporter assay, a direct interaction between miR-194 and the 3′-untranslated region (UTR) of STAT1 was confirmed. Additionally, miR-194 regulated mRNA and protein expression of STAT1 in BMSCs. Further analysis showed that miR-194 overexpression promoted the nuclear translocation of runt-related transcription factor 2 (Runx2), which is critical for osteoblast differentiation. In contrast, inhibition of miR-194 blocked the nuclear translocation of Runx2. Moreover, overexpression of STAT1 significantly blocked Runx2 nuclear translocation and osteoblast differentiation mediated by miR-194 overexpression. Taken together, our data suggest that miR-194 regulates osteoblast differentiation through modulating STAT1-mediated Runx2 nuclear translocation. - Highlights: • Overexpression of miR-194 significantly increased osteoblast differentiation. • miR-194 directly targeted the 3′- UTR of STAT1. • miR-194 regulated the expression of STAT1. • Overexpression of miR-194 promoted the nuclear translocation of Runx2.

  7. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott


    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  8. Production of tungsten-188 and osmium-194 in a nuclear reactor for new clinical generators

    Energy Technology Data Exchange (ETDEWEB)

    Mirzadeh, S.; Knapp, F.F. Jr.; Callahan, A.P.


    Rhenium-188 and iridium-194 are potential candidates for radioimmunotherapy with monoclonal antibodies directed against tumor-associated antigens. Both nuclei are short-lived and decay by high energy {Beta}{minus} emission. In addition, both nuclei emit {gamma}-rays with energy suitable for imaging. An important characteristics is availability of {sup 188}Re and {sup 194}Ir from decay of reactor-produced parents ({sup 188}W and {sup 194}Os, respectively) in convenient generator systems. The {sup 188}W and {sup 194}Os are produced by double neutron capture of {sup 186}W and {sup 192}Os, respectively. The large scale production yields of {sup 188}W in several nuclear reactors will be presented. We also report a new management for the cross-section of {sup 193}Os(n,{gamma}){sup 194}Os reaction and discuss the feasibility of producing sufficient quantities of {sup 194}Os. 17 refs., 1 fig., 2 tabs.

  9. INTEGRAL Observations of MAXI J1836-194

    DEFF Research Database (Denmark)

    Del Santo, M.; Kuulkers, E.; Rodriguez, J.


    . The source was also clearly detected by JEM-X at 23 sigma level in the 3-10 keV energy band with a flux of about 38 mCrab (~5 ks effective exposure time). The simultaneous IBIS/ISGRI+JEM-X 4-300 keV spectrum can be well described (chi2_red/d.o.f=1.0/18) by a power-law model with photon index 2...... on 2011-09-18 since 03:11:34.0 until 14:48:56.0. MAXI 1836-194 was detected by IBIS/ISGRI at a significance level of 32 sigma and 19 sigma in the 20-40 keV and 40-80 keV bands, respectively (~23 ks effective exposure time). The corresponding fluxes are roughly 48 mCrab and 44 mCrab, respectively...

  10. 24 CFR 200.194 - Placement of nonprofit organization on Nonprofit Organization Roster. (United States)


    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Placement of nonprofit organization on Nonprofit Organization Roster. 200.194 Section 200.194 Housing and Urban Development Regulations... Placement and Removal Procedures for Participation in FHA Programs Nonprofit Organization §...

  11. 40 CFR 194.53 - Consideration of underground sources of drinking water. (United States)


    ... of drinking water. 194.53 Section 194.53 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... underground sources of drinking water. In compliance assessments that analyze compliance with part 191, subpart C of this chapter, all underground sources of drinking water in the accessible environment...

  12. [Characteristics and identification of bacteriocins produced by Lactococcus lactis subsp. lactis 194-K]. (United States)

    Ustiugova, E A; Timofeeva, A V; Stoianova, L G; Netrusov, A I; Katrukha, G S


    The Lactococcus lactis subsp. lactis 194-K strain has been established to be able to produce two bacteriocins, one of which was identified as the known lantibiotic nisin A, and the other 194-D bacteriocin represents a polypeptide with a 2589-Da molecular mass and comprises 20 amino acid residues. Both bacteriocins were produced in varying proportions in all of the studied nutrient media, which support the growth of the producer. Depending on the cultivation medium, the nisin A content was 380- to 1123-fold lower in the 194-K stain culture fluid than that of the 194-D peptide. In comparision to to nisin A Bacteriocin 194-D possessed a wide range of antibacterial activity and suppressed the growth of both Gram-positive and Gram-negative bacteria. An optimal medium for 194-D bacteriocin synthesis was shown to be a fermentation medium which contained yeast extract, casein hydrolysate, and potassium phosphate. The biosynthesis ofbacteriocin 194-D by the 194-K strain in these media occurred parallel to producer growth, and its maximal accumulation in the culture fluid was observed at 14-20 h of the strain's growth.

  13. Removal of Acid Black 194 dye from water by electrocoagulation with aluminum anode. (United States)

    Vidal, Jorge; Villegas, Loreto; Peralta-Hernández, Juan M; Salazar González, Ricardo


    Application of an electrocoagulation process (EC) for the elimination of AB194 textile dye from synthetic and textile wastewater (effluent) contaminated with AB194 dye, was carried out using aluminum anodes at two different initial pH values. Tafel studies in the presence and absence of the dye were performed. The aluminum species formed during the electrolysis were quantified by atomic absorption, and the flocs formed in the process were analyzed by HPLC-MS. Complete removal of AB194 from 1.0 L of solution was achieved applying low densities current at initial pH values of 4.0 and 8.0. The removal of AB194 by EC was possible with a short electrolysis time, removing practically 100% of the total organic carbon content and chemical oxygen demand. The final result was completely discolored water lacking dye and organic matter. An effluent contaminated with 126 mg L(-1) AB194 dye from a Chilean textile industry was also treated by EC under optimized experimental conditions, yielding discolored water and considerably decreasing the presence of organic compounds (dye + dyeing additives), with very low concentrations of dissolved Al(3+). Analysis of flocs showed the presence of the original dye without changes in its chemical structure.

  14. RDDS lifetime measurements of low-lying superdeformed states in {sup 194}Hg

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, R.; Dewald, A.; Kruecken, R. [Universitaet Koeln (Germany)] [and others


    The lifetimes of three low-lying states in the superdeformed (SD) yrast band of {sup 194}Hg were measured by the recoil-distance Doppler-shift method. The deduced transition quadrupole moments, Q{sub t}, equal those extracted from a DSAM measurement for the high-lying states of the band corroborate the assumption that the decay out of SD bands does not strongly affect the structure of the corresponding states. By a simple mixing-model the decay can be described assuming a very small admixture of normal-deformed (ND) states to the decaying SD states. The deduced ND mixing amplitudes for the yrast SD bands in {sup 192,194}Hg and {sup 194}Pb are presented along with average transition quadrupole moments for the lower parts of the excited SD bands.

  15. An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211

    Energy Technology Data Exchange (ETDEWEB)

    O’Hara, Matthew J.; Krzysko, Anthony J.; Niver, Cynthia M.; Morrison, Samuel S.; Owsley, Stanley L.; Hamlin, Donald K.; Dorman, Eric F.; Scott Wilbur, D.


    Astatine-211 (211At) is a promising cyclotron-produced radionuclide being investigated for use in targeted alpha therapy of blood borne and metastatic cancers, as well as treatment of tumor remnants after surgical resections. The isolation of trace quantities of 211At, produced within several grams of a Bi metal cyclotron target, involves a complex, multi-step procedure: (1) Bi metal dissolution in strong HNO3, (2) distillation of the HNO3 to yield Bi salts containing 211At, (3) dissolution of the salts in strong HCl, (4) solvent extraction of 211At from bismuth salts with diisopropyl ether (DIPE), and (5) back-extraction of 211At from DIPE into NaOH, leading to a purified 211At product. Step (1) has been addressed first to begin the process of automating the onerous 211At isolation process. A computer-controlled Bi target dissolution system has been designed. The system performs in-line dissolution of Bi metal from the target assembly using an enclosed target dissolution block, routing the resulting solubilized 211At/Bi mixture to the subsequent process step. The primary parameters involved in Bi metal solubilization (HNO3 concentration and influent flow rate) were optimized prior to evaluation of the system performance on replicate cyclotron irradiated targets. The results indicate that the system performs reproducibly, having nearly quantitative release of 211At from irradiated targets, with cumulative 211At recoveries that follow a sigmoidal function. The predictable nature of the 211At release profile allows the user to tune the system to meet target processing requirements.

  16. New supersymmetric quartet of nuclei: 192Os, 193Os, 193Ir, 194Ir

    CERN Document Server

    Bijker, R; Frank, A; Graw, G; Hertenberger, R; Jolie, J; Wirth, H -F


    We present evidence of the existence of a new supersymmetric quartet of nuclei in the A=190 mass region. The analysis is based on new experimental information on the odd-odd nucleus 194Ir from transfer and capture reactions. The new data allow the identification of a new supersymmetric quartet, consisting of the 192,193Os and 193,194Ir nuclei. We make explicit predictions fo r193Os, and suggest that its spectroscopic properties be measured in dedicated experiments. Finally, we study correlations between different transfer reactions.

  17. 46 CFR 194.05-5 - Chemicals in the chemistry laboratory. (United States)


    ... 46 Shipping 7 2010-10-01 2010-10-01 false Chemicals in the chemistry laboratory. 194.05-5 Section....05-5 Chemicals in the chemistry laboratory. (a) Small working quantities of chemical stores in the chemistry laboratory which have been removed from the approved shipping container need not be marked...

  18. Results of 194 Double Stars Measurements from Astrometric CCD Observations at the Nikolaev Observatory (Ukraine) (United States)

    Bodryagin, Daniil; Bondarchuk, Larisa; Maigurova, Nadiia


    This paper presents the results of double stars measurements from CCD observations at the 50-cm telescope of the Nikolaev Observatory. The accurate positions at current epoch and proper motions were obtained for 194 WDS pairs. The position angles and separations were measured using REDUC software. The measures standard errors were 0.05" for separations and 0.2° for position angles.

  19. Yeast Interacting Proteins Database: YER081W, YDR194C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YDR194C MSS116 DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non...e name MSS116 Prey description DEAD-box protein required for efficient splicing of mitochondrial Group I and

  20. 19 CFR 191.194 - Action on application to participate in compliance program. (United States)


    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Action on application to participate in compliance... SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Drawback Compliance Program § 191.194 Action on application to participate in compliance program. (a) Review by applicable drawback office—(1) General. It...

  1. 12 CFR 19.194 - Eligibility of attorneys and accountants to practice. (United States)


    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Eligibility of attorneys and accountants to... Conduct § 19.194 Eligibility of attorneys and accountants to practice. (a) Attorneys. Any attorney who is... subpart may practice before the OCC. (b) Accountants. Any accountant who is qualified to practice as...

  2. 15 CFR 19.4 - What notice will Commerce entities send to a debtor when collecting a Commerce debt? (United States)


    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false What notice will Commerce entities send to a debtor when collecting a Commerce debt? 19.4 Section 19.4 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce Debts §...

  3. 43 CFR 19.4 - Liaison with other governmental agencies and submission of views by interested persons. (United States)


    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Liaison with other governmental agencies and submission of views by interested persons. 19.4 Section 19.4 Public Lands: Interior Office of the... recommendations as to the suitability or nonsuitability for preservation as wilderness of any roadless area in...

  4. Oral and maxillofacial trauma, 194 cases of clinical treatment experience%口腔颌面外伤194例临床治疗体会

    Institute of Scientific and Technical Information of China (English)



    Objective Analysis of oral and maxillofacial trauma, clinical treatment experience. methods Review of 194 patients admitted in our hospital in May 2010 to October 2012, oral and maxillofacial trauma patients clinical data, and take corresponding measures according to actual situation, analysis of patients with curative effect.Results 194 patients with oral and maxillofacial trauma cured by corresponding treatment, 102 cases of stage I wound healing, the patients with injury of soft tissue wound skin graft patients recovered well after 2 cases; Patients with maxillofacial bone fracture occlusal function returned to normal after treatment 87 cases, the recovery of facial appearance is good, two and a half to open mouth degrees. Teeth trauma patients with dental arch splint fixation treatment of 5 cases, demolition of plywood for teeth were fixed.Conclusion Oral and maxillofacial trauma patients with damage based on the actual situation, soft tissue injuries should be early debridement suture, should fracture reduction and ifxation, early early postoperative exercise activities, to try to restore the jaw joints function.%目的:分析口腔颌面外伤临床治疗体会。方法回顾我院2010年5月~2012年10月收治的口腔颌面外伤患者194例临床资料,并根据实际情况采取相应处理措施,分析患者疗效。结果194例口腔颌面外伤患者经相应处理治愈,软组织损伤患者伤口Ⅰ期愈合102例,创面后植皮患者恢复良好2例;颌面骨骨折患者治疗后咬合功能恢复正常87例,面部外观恢复良好,张口度两指半。牙外伤患者经牙弓夹板固定治疗5例,拆除夹板后患牙均固定。结论口腔颌面外伤患者经根据损伤实际情况,软组织损伤者需尽早清创缝合,骨折部位应早期复位固定,术后早期作活动锻炼,以此尽量恢复颞颌关节功能。

  5. Identification of miR-194-5p as a potential biomarker for postmenopausal osteoporosis. (United States)

    Meng, Jia; Zhang, Dapeng; Pan, Nanan; Sun, Ning; Wang, Qiujun; Fan, Jingxue; Zhou, Ping; Zhu, Wenliang; Jiang, Lihong


    The incidence of osteoporosis is high in postmenopausal women due to altered estrogen levels and continuous calcium loss that occurs with aging. Recent studies have shown that microRNAs (miRNAs) are involved in the development of osteoporosis. These miRNAs may be used as potential biomarkers to identify women at a high risk for developing the disease. In this study, whole blood samples were collected from 48 postmenopausal Chinese women with osteopenia or osteoporosis and pooled into six groups according to individual T-scores. A miRNA microarray analysis was performed on pooled blood samples to identify potential miRNA biomarkers for postmenopausal osteoporosis. Five miRNAs (miR-130b-3p, -151a-3p, -151b, -194-5p, and -590-5p) were identified in the microarray analysis. These dysregulated miRNAs were subjected to a pathway analysis investigating whether they were involved in regulating osteoporosis-related pathways. Among them, only miR-194-5p was enriched in multiple osteoporosis-related pathways. Enhanced miR-194-5p expression in women with osteoporosis was confirmed by quantitative reverse transcription-polymerase chain reaction analysis. For external validation, a significant correlation between the expression of miR-194-5p and T-scores was found in an independent patient collection comprised of 24 postmenopausal women with normal bone mineral density, 30 postmenopausal women with osteopenia, and 32 postmenopausal women with osteoporosis (p osteoporosis.

  6. Formation of the isomeric pair 194Irm,g in interactions of [alpha] particles with 192Os


    Uddin, M. S.; Sudár Sándor (1946-) (fizikus); Qaim, Syed M.


    Cross sections were measured by the activation technique for the nuclear processes Os-192(alpha,d+pn+np)Ir-194(m,g) up to alpha-particle energies of 39 MeV. From the measured data the isomeric cross-section ratio was deduced as a function of projectile energy. The present experimental data as well as those for the Pt-194(n,p)Ir-194(m,g) reaction, given in the literature, were compared with the results of nuclear model calculations using the code TALYS, which combines the statistical, precompo...

  7. D194 G突变对meso-2,3-丁二醇脱氢酶催化特性的影响%Effects of D194G Mutant on meso-2, 3-Butanediol Dehydrogenase Catalytic Properties

    Institute of Scientific and Technical Information of China (English)

    郝文博; 姬芳玲; 王静云; 张悦; 王天琪; 车文实; 包永明


    目的:比较来源于Enterobacter aerogenes CICC10293和Bacillus subtilis的meso-2,3-丁二醇脱氢酶(E.a-BDH和D194G B.s-BDH)活性和动力学参数,分析D194氨基酸对BDH催化特性的影响.方法:利用E.coli BL21(DE3)原核表达E.a-BDH和D194GB.s-BDH,经HiTrap Q FF阴离子交换柱和Superdex 75凝胶柱纯化后,用MALDI-TOF MS确定其分子质量;检测NADH/NAD+氧化还原的吸光度变化确定BDH活性、辅酶和底物的特异性、最适pH、温度及动力学参数.结果:重组表达E.a-BDH和D194G B.s-BDH是同源四聚体蛋白,基因序列有两处碱基不同(g.27A/T和g.581A/G),其中g.581A/G导致BDH的一处氨基酸发生改变(p.D194G).D194G B.s-BDH的活性约为E.a-BDH的2.3%,并且丧失了氧化meso-2,3-丁二醇的能力.二者均以乙偶姻/NADH为最适底物,但D194G B.s-BDH的Km是E.a-BDH的5.63倍.结论:D194G氨基酸突变降低了BDH的活性.

  8. Investigation on Mental Status of 194 Nurses from High Risk Department%194名高风险护理人员心理状况调查分析

    Institute of Scientific and Technical Information of China (English)

    陈晓梅; 纪香萍


    目的探讨乌鲁木齐市属各所医院从事(IC U、手术室、急诊科、产科)高风险护理人员的心理健康状况,为心理干预提供依据。方法采用症状自评量表(SCL -90)对市属5所医院从事(ICU、手术室、急诊科、产科)高风险护理人员194名进行测试。结果从事高风险护理人员的SCL -90各因子分(除人际关系外)明显高于SCL -90中国常模,有显著性差异(P<0.05)。结论从事高风险护理人员的心理健康水平明显低于正常人群,其心理健康状况应引起管理者的高度重视。%Objective To investigate the mental health condition of the nurses engaged in the high risk department (ICU ,operating room ,emergency department ,obstetrics)in Urumqi municipal hospitals .Methods Use the Symptom Checklist (SCL -90) to test the mental health condition of 194 nurses engaged in the high risk department (ICU ,operating room ,emergency department ,obstetrics) in six municipal hospitals .Results The SCL -90 scores of the nurses engaged in the high risk department is significantly higher than the norm (P<0 .05) .It's statistically significant except the personal re-lationship .Conclusion The health level of the nurses engaged in the high risk department is significantly lower than the normal person ,their mental health should attract more attention of the hospital administrators and the whole community .

  9. Study of the Alpha-Decay Chain for7753 194Rn with Relativistic Mean-Field Theory

    Institute of Scientific and Technical Information of China (English)

    SHENG Zong-Qiang; GUO Jian-You


    The structures of the nuclei on the alpha-decay chain of 194Rn are investigated in the deformed relativistic mean-field theory with the effective interaction TMA. We put an emphasis on the ground state properties of 194Rn. The calculated alpha-decay energies and lifetimes are both very close to the experimental data for 186pb and 190po. For 194 Rn, the deviations are a little large on both the alpha-decay energy and the lifetime. We also calculate the alpha-decay energies for the isotopes 192~208Rn. The tendency for the change of the alpha-decay energies with neutron number is correctly reproduced in the relativistic mean-field theory (RMF). In general, the RMF theory can give a good description of the alpha decay chain of 194Rn.

  10. DSAM lifetime measurements for the chiral pair in {sup 194}Tl

    Energy Technology Data Exchange (ETDEWEB)

    Masiteng, P.L.; Bvumbi, S.P. [National Research Foundation, iThemba LABS, PO Box 722, Somerset West (South Africa); University of the Western Cape, Private Bag X17, Bellville (South Africa); University of Johannesburg, PO Box 524, Auckland Park (South Africa); Pasternak, A.A. [A.F. Ioffe Physical-Technical Institute, St.-Petersburg (Russian Federation); Lawrie, E.A.; Shirinda, O.; Lawrie, J.J.; Bark, R.A.; Kheswa, N.Y.; Lieder, E.O.; Lieder, R.M.; Mullins, S.M.; Murray, S.H.T. [National Research Foundation, iThemba LABS, PO Box 722, Somerset West (South Africa); Lindsay, R. [University of the Western Cape, Private Bag X17, Bellville (South Africa); Madiba, T.E.; Sharpey-Schafer, J.F. [National Research Foundation, iThemba LABS, PO Box 722, Somerset West (South Africa); University of the Western Cape, Private Bag X17, Bellville (South Africa); Ndayishimye, J.; Papka, P. [National Research Foundation, iThemba LABS, PO Box 722, Somerset West (South Africa); University of Stellenbosch, Department of Physics, Private Bag X1, Matieland (South Africa); Ntshangase, S.S. [National Research Foundation, iThemba LABS, PO Box 722, Somerset West (South Africa); University of Cape Town, Department of Physics, Private Bag, Rondebosch (South Africa)


    Most important for the identification of chiral symmetry in atomic nuclei is to establish a pair of bands that are near-degenerate in energy, but also in B(M1) and B(E2) transition probabilities. Dedicated lifetime measurements were performed for four bands of {sup 194}Tl, including the pair of four-quasiparticle chiral bands with close near-degeneracy, considered as a prime candidate for best chiral symmetry pair. The lifetime measurements confirm the excellent near-degeneracy in this pair and indicate that a third band may be involved in the chiral symmetry scenario. (orig.)

  11. Microbial colonization of normal skin: Direct visualization of 194 skin biopsies. (United States)

    Jahns, Anika C; Alexeyev, Oleg A


    Recent genetic studies have suggested the presence of numerous microbial species on and in the skin. We characterised microbial colonization of a large collection of skin biopsies from 194 healthy subjects by fluorescence assay. Forty per cent of all biopsies did not show any evidence for microbial colonization. Propionibacterium acnes was the sole predominant bacterial species in both sebaceous and non-sebaceous areas. Non- P. acnes species were present in approximately 30% of all colonized samples. . Only hair follicles and stratum corneum were colonized. Understanding of cutaneous microbiota requires validation from a variety of approaches and techniques.

  12. Sum-frequency generation of continuous-wave light at 194 nm. (United States)

    Berkeland, D J; Cruz, F C; Bergquist, J C


    Over 2 mW of continuous-wave tunable 194-nm light is produced by sum-frequency mixing approximately 500 mW of 792-nm and 500 mW of 257-nm radiation in beta-barium borate (BBO). The powers in both fundamental beams are enhanced in separate ring cavities whose optical paths overlap in the Brewster-cut BBO crystal. Due to the higher circulating fundamental powers, the sum-frequency-generated power is nearly 2 orders of magnitude greater than previously reported values.

  13. 19.4%-efficient large-area fully screen-printed silicon solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Gatz, Sebastian; Hannebauer, Helge; Hesse, Rene; Werner, Florian; Schmidt, Arne; Dullweber, Thorsten; Bothe, Karsten [Institute for Solar Energy Hamelin (ISFH), Am Ohrberg 1, 31860 Emmerthal (Germany); Schmidt, Jan; Brendel, Rolf [Institute for Solar Energy Hamelin (ISFH), Am Ohrberg 1, 31860 Emmerthal (Germany); Institute of Solid-State Physics, University of Hannover, Appelstrasse 2, 30167 Hannover (Germany)


    We demonstrate industrially feasible large-area solar cells with passivated homogeneous emitter and rear achieving energy conversion efficiencies of up to 19.4% on 125 x 125 mm{sup 2} p-type 2-3 {omega} cm boron-doped Czochralski silicon wafers. Front and rear metal contacts are fabricated by screen-printing of silver and aluminum paste and firing in a conventional belt furnace. We implement two different dielectric rear surface passivation stacks: (i) a thermally grown silicon dioxide/silicon nitride stack and (ii) an atomic-layer-deposited aluminum oxide/silicon nitride stack. The dielectrics at the rear result in a decreased surface recombination velocity of S{sub rear} = 70 cm/s and 80 cm/s, and an increased internal IR reflectance of up to 91% corresponding to an improved J{sub sc} of up to 38.9 mA/cm{sup 2} and V{sub oc} of up to 664 mV. We observe an increase in cell efficiency of 0.8% absolute for the cells compared to 18.6% efficient reference solar cells featuring a full-area aluminum back surface field. To our knowledge, the energy conversion efficiency of 19.4% is the best value reported so far for large area screen-printed solar cells. (copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  14. Imunogenicidade da cepa avirulenta RV194-2 do vírus rábico em camundongos

    Directory of Open Access Journals (Sweden)

    Rugimar Marcovistz


    Full Text Available O vírus rábico RV194-2, uma variante avirulenta da cepa CVS (Challenge Vírus Standard, produz uma infecção inaparente quando inoculado intracerebralmente em camundongos adultos. Sugerindo que a resposta imunológica do hospedeiro permite a eliminação do vírus do sistema nervoso central. Por esta razão foram estudadas a indução de interferon e a resposta imune humoral em camundongos BALB/c inoculados com vírus RV194-2. Durante a infecção, estes camundongos apresentaram elevados níveis de interferon no plasma e no cérebro com altos títulos de anticorpos neutralizantes anti-rábicos. A 2-5A sintetase. um marcador da ação dos interferons,foi também analisada no cérebro destes animais. Sua atividade, aumentou, paralelamente, á produção de interferon, demonstrando que este interferon é bioquímicamente ativo. O vírus RV194-2 também induziu, 45 dias após sua inoculação, proteção aos animais quando desafiados com a cepa virulenta CVS. Estes resultados demonstram que a cepa RV194-2possui um alto nível imunogênico.RV194-2 rabies virus, an avirulent mutant of CVS strain, induces an inapparent infection limited to the central nervous system (CNS in adult mice inoculated intracerebrally. This fact suggest that immune response of the host is able to eliminate the virus in CNS. For this reason, we have studied the induction of interferon and the humoral immune responses in BALB/c mice after RV194-2 inoculation. These mice presented high levels of interferon in the plasma and in the brain, with elevated levels of neutralizing antirabies antibodies. The 2-5A synthetase, an enzyme marker of interferon action, was analyzed in the brain of inoculated animals. Its enhancement in parallel to the interferon production in the brain, showed biochemical evidence that this interferon is active. Forty five days after RV194-2 virus inoculation, mice were protected against a challenge with the CVS virulent strain. The results presented

  15. 194例糖尿病病人军团菌感染情况调查

    Institute of Scientific and Technical Information of China (English)

    权怡; 方锦嵩


    @@ 军团病(Legionnaires'Disease,LD)是由军团菌引起的以呼吸症状为主,伴发全身中毒症状的细菌性疾病.目前已命名的39种61个血清型军团菌中,以嗜肺军团菌(Legionella Pneumophila,LP)报道最多.针对糖尿病病人抗感染能力降低,常易并发化脓性感染、尿路感染、肺结核等[1],我们对194例糖尿病病人军团菌感染情况进行调查,现报告如下.

  16. Spectral and Temporal Properties of MAXI J1836-194 during 2011 Outburst

    CERN Document Server

    Jana, A; Mondal, S; Chakrabarti, S K; Molla, A A; Chatterjee, D


    We study black hole candidate (BHC) MAXI~J1836-194 during its 2011 outburst with Two Component Advective Flow (TCAF) model using RXTE/PCU2 data in $2.5-25$~keV band. From spectral fit, accretion flow parameters such as Keplerian disk rate ($\\dot{m_d}$), sub-Keplerian halo rate ($\\dot{m_h}$), shock location ($X_{s}$) and compression ratio (R) are extracted directly. During the entire phase of the outburst, quasi-periodic oscillations (QPOs) are observed sporadically. From the nature of the variation of accretion rate ratio (ARR=$\\dot{m_h}$ / $\\dot{m_d}$) and QPOs, entire period of the outburst is classified in two spectral states, such as, hard (HS), hard-intermediate (HIMS). Unlike other transient BHCs, no signature of soft (SS) and soft-intermediate (SIMS) spectral states are observed during entire phase of the outburst

  17. 22 CFR 19.4 - Special rules for computing creditable service for purposes of payments to former spouses. (United States)


    ... DISABILITY SYSTEM § 19.4 Special rules for computing creditable service for purposes of payments to former... principal's approved leave without pay during full-time service with an organization composed primarily of Government employees irrespective of whether the principal elects to make payments to the Fund for...

  18. Primary transitions between the yrast superdeformed band and low-lying normal deformed states in {sup 194}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Hauschild, K.; Bernstein, L.A.; Becker, J.A. [Lawrence Livermore National Lab., CA (United States)] [and others


    The observation of one-step `primary` gamma-ray transitions directly linking the superdeformed (SD) states to the normal deformed (ND) low-lying states of known excitation energies (E{sub x}), spins and parities (J{sup {pi}}) is crucial to determining the E{sub x} and J{sup {pi}} of the SD states. With this knowledge one can begin to address some of the outstanding problems associated with SD nuclei, such as the identical band issue, and one can also place more stringent restrictions on theoretical calculations which predict SD states and their properties. Brinkman, et al., used the early implementation of the GAMMASPHERE spectrometer array (32 detectors) and proposed a single, candidate {gamma} ray linking the {sup 194}Pb yrast SD band to the low-lying ND states in {sup 194}Pb. Using 55 detectors in the GAMMASPHERE array Khoo, et al., observed multiple links between the yrast SD band in {sup 194}Hg and the low-lying level scheme and conclusively determined E{sub x} and J of the yrast SD states. Here the authors report on an experiment in which Gammasphere with 88 detectors was used and the E{sub x} and J{sup {pi}} values of the yrast SD states in {sup 194}Pb were uniquely determined. Twelve one-step linking transitions between the yrast SD band and low-lying states in {sup 194}Pb have been identified, including the transition proposed by Brinkman. These transitions have been placed in the level scheme of {sup 194}Pb using coincidence relationships and agreements between the energies of the primary transitions and the energy differences in level spacings. Furthermore, measurements of angular asymmetries have yielded the multipolarities of the primaries which have allowed J{sup {pi}} assignments of the {sup 194}Pb SD states to be unambiguously determined for the first time without a priori assumptions about the character of SD bands. A study performed in parallel to this work using the EUROGAM-II array reports similar, but somewhat less extensive, results.

  19. Human furin Cys198 imposes dihedral and positional restraints on His194 for optimal Ser386-proton transfer. (United States)

    Omotuyi, Olaposi I; Hamada, Tsuyoshi


    Inhibitors of human furin may represent the clinical remedy for very aggressive cancer, viral, and bacterial infections. Most of the currently available inhibitors are weak in terms of potency, drug-likeness, and furin specificity thereby necessitating the development of newer compounds especially mechanism-based inhibitors. Here, the roles of active site Cys198 (C198), His194 (H194), and Ser386 (S386) were investigated using computational-site-directed mutagenesis and molecular dynamics (MD) simulation. Data were obtained from six (6) biosystems: wildtype (C198/S386), furin-C198G (S386), furin-S386G (C198), and their peptide (nascent hydrolyzed peptide H2N-RTRR-CO2) bound complexes. The results strongly supported that in wildtype furin but not S386G and C198G mutants, following S386/scissile carbon attack (4.0 Å), the peptide retracted from the active site, representing peptide release post hydrolysis. Furthermore, in S386G mutant, C194 side chain thiolate ion may act as the nucleophile replacement but competing electron-rich centers (H194, H364) and energetically unattainable geometric strain on the peptide may constitute the limiting factors. In biosystems not complexed with peptide (representative of pre-attack state), C198 preferentially engaged H194 imidazole moiety via sulfur-π bond system causing a dihedral and positional restraints on the imidazole ring for ultimate alignment of its NE2 hydrogen atom with the side chain enolate oxygen of S364 required for optimal proton transfer. In summary, small-molecular-weight compounds with dual serine and cysteine protease inhibitory actions may represent a new class of potent and furin-selective compounds for future clinical applications.

  20. a194yb.m77t and a194yb.h77t: MGD77T data and header files for single-beam bathymetry for field activity A-1-94-YB in Yakutat Bay and Yakutat Sea Valley, Alaska from 08/05/1994 to 08/08/1994 (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with GPS navigation data was collected as part of the U.S. Geological Survey cruise A-1-94-YB. The cruise was conducted in Yakutat...

  1. a194gb.m77t and a194gb.h77t: MGD77T data and header files for single-beam bathymetry data for field activity A-1-94-GB in Prince William Sound, Yakutat Bay, Glacier Bay and Icy Strait, Alaska from 08/08/1994 to 08/17/1994 (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with GPS navigation data was collected as part of the U.S. Geological Survey cruise A-1-94-GB. The cruise was conducted in Prince...

  2. p194ar.m77t and p194ar.h77t: MGD77T data and header files for single-beam bathymetry data for field activity P-1-94-AR in Arctic Ocean from 07/25/1994 to 08/30/1994 (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with SINS navigation data was collected as part of the U.S. Geological Survey cruise P-1-94-AR. The cruise was conducted in...

  3. k194hw.m77t and k194hw.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-1-94-HW in Mamala Bay, Offshore Honolulu, Oahu, Hawaii from 05/10/1994 to 05/16/1994 (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with DGPS navigation data was collected as part of the U.S. Geological Survey cruise K-1-94-HW. The cruise was conducted in Oahu,...

  4. About the nature of competing interactions in cerium based 1-9-4 compounds; Ueber die Natur konkurrierender Wechselwirkungen in Cer-basierten 1-9-4 Verbindungen

    Energy Technology Data Exchange (ETDEWEB)

    Gold, Christian


    In addition to the high-temperature superconductors, the so-called heavy fermion systems are among the most fascinating representatives of strongly correlated electron systems. Caused by the competition of Kondo effect, RKKY interaction and electrostatic crystal field effects these compounds reveal a wide variety of different ground state properties. For example, many of these systems are located in the vicinity of a magnetic instability. At such a quantum critical point a continuous transition between two states with different symmetry occurs at absolute zero temperature. Apart from the three classic tuning parameters (i) chemical substitution, (ii) hydrostatic pressure, and (iii) external magnetic field also the reduction of the effective spin degeneracy N, i.e. the reduction of the number of crystal field levels which are shielded by the Kondo effect seems to induce quantum critical behavior. The proximity to a quantum critical point together with an unusually high effective spin degeneracy of N=4 make the ternary 1-9-4 compound CeNi{sub 9}Ge{sub 4} the perfect starting system for experimental studies of this new parameter. For the first and so far only time such a scenario could be observed in the substitution series CeNi{sub 9-x}Cu{sub x}Ge{sub 4} (0≤x≤1). Extensive studies show that in this system quantum criticality is not only caused by the balance between Kondo effect and RKKY interaction but also by a reduction of the effective spin degeneracy. The results on the copper series provided the incentive to synthesize and analyze related systems with regard to quantum criticality in the scope of this work. The focus here was on the systems CeNi{sub 9}Ge{sub 4-x}Si{sub x}, CeNi{sub 9}Ge{sub 4-x}Ga{sub x}, CeNi{sub 9-x}Fe{sub x}Ge{sub 4} and CeNi{sub 9-x}Co{sub x}Ge{sub 4}. This thesis was methodologically supported by X-ray studies, theoretical LDA+U calculations and extensive thermodynamic and magnetic investigations on the macroscopic and microscopic

  5. Accretion flow dynamics of MAXI J1836-194 during its 2011 outburst from TCAF solution

    CERN Document Server

    Jana, Arghajit; Chakrabarti, Sandip K; Mondal, Santanu; Molla, Aslam Ali


    The Galactic transient X-ray binary MAXI J1836-194 was discovered on 29th Aug. 2011. Here we make a detailed study of the spectral and timing properties of its 2011 outburst using archival data of RXTE Proportional Counter Array instrument. The evolution of accretion flow dynamics of the source during the outburst through spectral analysis with Chakrabarti-Titarchuk's two-component advective flow (TCAF) solution as a local table model in XSPEC. We also fitted spectra with combined disk blackbody and power-law models and compare it with that of the TCAF model fitted results. The source is found to be in hard and hard-intermediate spectral states only during entire phase of this outburst. No soft and soft-intermediate spectral states are observed. This could be due to the fact that this object belongs to a special class of sources (with, e.g., MAXI J1659-152, Swift J1753.5-0127, etc.) having very short orbital periods and the companion is profusely mass losing or the disk is immersed inside an excretion disk. I...

  6. VLBI detection of the Galactic black hole binary candidate MAXI J1836-194

    CERN Document Server

    Yang, Jun; Li, Zhixuan; Paragi, Zsolt; Campbell, Robert M; Gurvits, Leonid; Shen, Zhiqiang; Hong, Xiaoyu; Xia, Bo


    The X-ray transient MAXI J1836-194 is a newly-identified Galactic black hole binary candidate. As most X-ray transients, it was discovered at the beginning of an X-ray outburst. After the initial canonical X-ray hard state, the outburst evolved into a hard intermediate state and then went back to the hard state. The existing RATAN-600 radio monitoring observations revealed that it was variable on a timescale of days and had a flat or inverted spectrum, consistent with optically thick synchrotron emission, possibly from a self-absorbed jet in the vicinity of the central compact object. We observed the transient in the hard state near the end of the X-ray outburst with the European VLBI Network (EVN) at 5 GHz and the Chinese VLBI Network (CVN) at 2.3 and 8.3 GHz. The 8.3 GHz observations were carried out at a recording rate of 2048 Mbps using the newly-developed Chinese VLBI data acquisition system (CDAS), twice higher than the recording rate used in the other observations. We successfully detected the low-decl...

  7. Tidal bridge and tidal dwarf candidates in the interacting system Arp194

    CERN Document Server

    Zasov, Anatoly; Egorov, Oleg; Afanasiev, Viktor


    Arp194 is a system of recently collided galaxies, where the southern galaxy (S) passed through the gaseous disc of the northern galaxy (N) which in turn consists of two close components. This system is of special interest due to the presence of regions of active star-formation in the bridge between galaxies, the brightest of which (the region A) has a size of at least 4 kpc. We obtained three spectral slices of the system for different slit positions at the 6-m telescope of SAO RAS. We estimated the radial distribution of line-of-sight velocity and velocity dispersion as well as the intensities of emission lines and oxygen abundance $12+\\log(\\mathrm{O/H})$. The gas in the bridge is only partially mixed chemically and spatially: we observe the O/H gradient with the galactocentric distances both from S and N galaxies and a high dispersion of O/H in the outskirts of N-galaxy. Velocity dispersion of the emission-line gas is the lowest in the star-forming sites of the bridge and exceeds 50-70 km/s in the disturbed...

  8. Health systems and the right to health: an assessment of 194 countries. (United States)

    Backman, Gunilla; Hunt, Paul; Khosla, Rajat; Jaramillo-Strouss, Camila; Fikre, Belachew Mekuria; Rumble, Caroline; Pevalin, David; Páez, David Acurio; Pineda, Mónica Armijos; Frisancho, Ariel; Tarco, Duniska; Motlagh, Mitra; Farcasanu, Dana; Vladescu, Cristian


    60 years ago, the Universal Declaration of Human Rights laid the foundations for the right to the highest attainable standard of health. This right is central to the creation of equitable health systems. We identify some of the right-to health features of health systems, such as a comprehensive national health plan, and propose 72 indicators that reflect some of these features. We collect globally processed data on these indicators for 194 countries and national data for Ecuador, Mozambique, Peru, Romania, and Sweden. Globally processed data were not available for 18 indicators for any country, suggesting that organisations that obtain such data give insufficient attention to the right-to-health features of health systems. Where they are available, the indicators show where health systems need to be improved to better realise the right to health. We provide recommendations for governments, international bodies, civil-society organisations, and other institutions and suggest that these indicators and data, although not perfect, provide a basis for the monitoring of health systems and the progressive realisation of the right to health. Right-to-health features are not just good management, justice, or humanitarianism, they are obligations under human-rights law.

  9. Valproate Treatment in an ALS Patient Carrying a c.194G>A Spastin Mutation and SMN2 Homozygous Deletion

    Directory of Open Access Journals (Sweden)

    Lucio Tremolizzo


    Full Text Available Here we report the case of an ALS patient found to carry both a novel heterozygous change (c.194G>A within the spastin gene and a homozygous deletion of the SMN2 gene. The patient was started on valproic acid (VPA, 600 mg/die per os considering the capacity of this drug of increasing survival motor neuron through an epigenetic mechanism. Patient clinical course and molecular effects of VPA on skin fibroblasts obtained from the proband are described. This c.194G>A spastin mutation might expand the previously known borders of type 4 spastic paraplegia (SPG4 and we suggest the intriguing possibility that the absence of SMN2 might have acted as a contributory risk factor for starting lower motor neuron damage. Exploring the relationship genocopy-phenocopy in selected ALS patients might represent an interesting strategy for understanding its clinical variability.

  10. MiRNA-194 Regulates Palmitic Acid-Induced Toll-Like Receptor 4 Inflammatory Responses in THP-1 Cells. (United States)

    Tian, Huiqun; Liu, Chaoqi; Zou, Xiaohua; Wu, Wei; Zhang, Changcheng; Yuan, Ding


    There is strong evidence to suggest that inflammatory responses link obesity and diseases, and the understanding of obesity-induced inflammatory mechanisms is central to the pathogenesis of diseases such asnonalcoholic fatty liver disease(NAFLD) and atherosclerosis that are modified by obesity. Based on this, anti-inflammatory treatments become a potential therapies for obesity-related diseases like NAFLD.A critical role of toll-like receptor (TLR) and its downstream molecules such as tumor necrosis factor receptor-associated factor 6(TRAF6) has been documented in inflammatory response induced by fatty acid. TLR pathway regulation provides a new insight to controlling the inflammatory response induced by fatty acid. Taken together, our study was aimed to understand the mechanism of fatty acid-mediated inflammation and look for an effective target which can prevent the inflammatory response induced by obesity. In this study, we used the saturated fatty acid palmitic acid (PA) to activate TLR4 signal pathway in human monocyte cells THP-1 that established an intracellular inflammatory model. Followed with activated TLR4, downstream molecular TRAF6 was upregulated and ultimately induced proinflammatory cytokine production. Based on this model, we also found that PA downregulated miR-194 expression with TLR4 activation. Moreover, our results showed that key signal molecular TRAF6 is a target of miR-194, overexpression of miR-194 directly decreased TRAF6 expression and attenuated the release of proinflammatory cytokine TNF-α in PA-activated monocyte THP-1. We conclude that miR-194 negatively regulates the TLR4 signal pathway which is activated by PA through directly negative TRAF6 expression.

  11. 194例婴幼儿麻疹临床及流行病学特征的分析%An analysis of clinical and epidemiological features of 194 cases of infants with measles

    Institute of Scientific and Technical Information of China (English)



    Objective To explore the clinical and epidemiological features of 194 cases of infants with measles in Huadu. Methods Retrospective analysis of clinical data of 194 cases of infants with measles in Huadu from 2010 to 2014 were made,and it was analyzed by descriptive epidemiological methods. Results 194 infants with measles were diagnosed in Huadu from 2010 to 2014.Morbidity in the infants under 1 years old was highest (P < 0.05),and the onset of the disease were mainly in March and April.Morbidity of floating population was significantly higher than that of local population (P < 0.05),and Morbidity of people without history of vaccination and people with measles contact was significantly higher (P < 0.05). Conclusion Measures can be taken to control the morbidity of measles effectively including good seasonal prevention,expanding measles immunization timely,raising the vaccination rate of floating and rural population and strengthening vaccination of high-risk population.%目的:探讨花都区婴幼儿麻疹临床及流行病学特点。方法回顾性分析花都区2010~2014年194例婴幼儿麻疹的临床资料,并进行描述性流行病学分析。结果2010年~2014花都区共出现婴幼儿麻疹194例,年龄<1岁发病率最高(P <0.05),发病时间主要集中于3、4月份,流动人口发病率明显高于本地户籍人口(P <0.05),无免疫接种史和有麻疹接触史者发病率明显要高(P <0.05)。结论做好季节性预防,及时扩大麻疹免疫接种范围,提高流动人口和农村人口的接种率,加强对高危人群免疫接种,可达到有效控制麻疹发病率的作用。

  12. Tidal bridge and tidal dwarf candidates in the interacting system Arp194 (United States)

    Zasov, Anatoly V.; Saburova, Anna S.; Egorov, Oleg V.; Afanasiev, Viktor L.


    Arp194 is a system of recently collided galaxies, where the southern galaxy (S) passed through the gaseous disc of the northern galaxy (N) which in turn consists of two close components. This system is of special interest due to the presence of regions of active star formation in the bridge between galaxies, the brightest of which (the region A) has a size of at least 4 kpc. We obtained three spectral slices of the system for different slit positions at the 6-m telescope of SAO RAS. We estimated the radial distribution of line-of-sight velocity and velocity dispersion as well as the intensities of emission lines and oxygen abundance 12 + log (O/H). The gas in the bridge is only partially mixed chemically and spatially: we observe the O/H gradient with the galactocentric distances both from S and N galaxies and a high dispersion of O/H in the outskirts of N-galaxy. Velocity dispersion of the emission-line gas is the lowest in the star-forming sites of the bridge and exceeds 50-70 km s-1 in the disturbed region of N-galaxy. Based on the SDSS photometrical data and our kinematical profiles we measured the masses of stellar population and the dynamical masses of individual objects. We confirm that the region A is the gravitationally bound tidal dwarf with the age of 107-108 yr, which is falling on to the parent S-galaxy. There is no evidence of the significant amount of dark matter in this dwarf galaxy.

  13. XRCC1 Arg194Trp and Arg399Gln polymorphisms and arsenic methylation capacity are associated with urothelial carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Chiang, Chien-I [School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan (China); Huang, Ya-Li [Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (China); Chen, Wei-Jen [School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan (China); Shiue, Horng-Sheng [Department of Chinese Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan (China); Huang, Chao-Yuan; Pu, Yeong-Shiau [Department of Urology, National Taiwan University Hospital, College of Medicine National Taiwan University, Taipei, Taiwan (China); Lin, Ying-Chin [Department of Family Medicine, Shung Ho Hospital, Taipei Medical University, New Taipei, Taiwan (China); Department of Health Examination, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan (China); Division of Family Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan (China); Hsueh, Yu-Mei, E-mail: [School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan (China); Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (China)


    The association between DNA repair gene polymorphisms and bladder cancer has been widely studied. However, few studies have examined the correlation between urothelial carcinoma (UC) and arsenic or its metabolites. The aim of this study was to examine the association between polymorphisms of the DNA repair genes, XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, and XPD Lys751Gln, with urinary arsenic profiles and UC. To this end, we conducted a hospital-based case–control study with 324 UC patients and 647 age- and gender-matched non-cancer controls. Genomic DNA was used to examine the genotype of XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, and XPD Lys751Gln by PCR-restriction fragment length polymorphism analysis (PCR-RFLP). Urinary arsenic profiles were measured by high performance liquid chromatography (HPLC) linked with hydride generator and atomic absorption spectrometry. The XRCC1 399 Gln/Gln and 194 Arg/Trp and Trp/Trp genotypes were significantly related to UC, and the odds ratio (OR) and 95% confidence interval (95%CI) were 1.68 (1.03–2.75) and 0.66 (0.48–0.90), respectively. Participants with higher total urinary arsenic levels, a higher percentage of inorganic arsenic (InAs%) and a lower percentage of dimethylarsinic acid (DMA%) had a higher OR of UC. Participants carrying XRCC1 risk diplotypes G-C/G-C, A-C/A-C, and A-T/G-T, and who had higher total arsenic levels, higher InAs%, or lower DMA% compared to those with other XRCC1 diplotypes had a higher OR of UC. Our results suggest that the XRCC1 399 Gln/Gln and 194 Arg/Arg DNA repair genes play an important role in poor arsenic methylation capacity, thereby increasing the risk of UC in non-obvious arsenic exposure areas. - Highlights: • The XRCC1 399Gln/Gln genotype was significantly associated with increased OR of UC. • The XRCC1 194 Arg/Trp and Trp/Trp genotype had a significantly decreased OR of UC. • Combined effect of the XRCC1 genotypes and poor arsenic methylation capacity on

  14. Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis. (United States)

    Pruszyński, Marek; Bilewicz, Aleksander; Zalutsky, Michael R


    The goal of this study was to evaluate a new approach that can be applied for labeling biomolecules with (211)At. Many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking different (211)At labeling strategies. The approach evaluated in this study was to attach astatide anions to soft metal cations, which are also complexed by a bifunctional ligand. Ultimately, this complex could in principle be subsequently conjugated to a biomolecule with the proper selection of ligand functionality. We report here the attachment of (211)At(-) and *I(-) (*I = (131)I or (125)I) anions to the soft metal cations Rh(III) and Ir(III), which are complexed by the 1,5,9,13-tetrathiacyclohexadecane-3,11-diol (16aneS4-diol) ligand. Radioactive *I(-) anions were used for preliminary studies directed at the optimization of reaction conditions and to provide a baseline for comparison of results with (211)At. Four complexes Rh[16aneS4-diol]*I/(211)At and Ir[16aneS4-diol]*I/(211)At were synthesized in high yield in a one-step procedure, and the products were characterized mainly by paper electrophoresis and reversed-phase HPLC. The influences of time and temperature of heating and concentrations of metal cations and sulfur ligand 16aneS4-diol, as well as pH on the reaction yields were determined. Yields of about 80% were obtained when the quantities of Rh(III) or Ir(III) cations and 16aneS4-diol ligand in the solutions were 62.5 nmol and 250 nmol, respectively, and the pH ranged 3.0-4.0. Syntheses required heating for 1-1.5 h at 75-80 degrees C. The influence of microwave heating on the time and completeness of the complexation reaction was evaluated and compared with the conventional method of heating in an oil bath. Microwave synthesis accelerates reactions significantly. With microwave heating, yields of about 75% for Rh[16aneS4-diol](131)I and Ir[16aneS4-diol](131)I complexes were obtained after only 20 min exposure of the reaction mixtures to

  15. An Evolving Compact Jet in the Black Hole X-Ray Binary MAXI J1836-194


    Russell, D.M.; et al; Markoff, S.; Homan, J.; Altamirano, D.


    We report striking changes in the broadband spectrum of the compact jet of the black hole transient MAXI J1836-194 over state transitions during its discovery outburst in 2011. A fading of the optical-infrared (IR) flux occurred as the source entered the hard-intermediate state, followed by a brightening as it returned to the hard state. The optical-IR spectrum was consistent with a power law from optically thin synchrotron emission, except when the X-ray spectrum was softest. By fitting the ...

  16. All-fiber 194 W single-frequency single-mode Yb-doped master-oscillator power-amplifier (United States)

    Mermelstein, M. D.; Brar, K.; Andrejco, M. J.; Yablon, A. D.; Fishteyn, M.; Headley, C., III; DiGiovanni, D. J.


    A four-stage all-fiber single-frequency single-mode continuous-wave (cw) master-oscillator power-amplifier (MOPA) at 1083 nm is presented. Small mode area (SMA) and large mode area (LMA) amplifier stages are mode matched with a fiber mode converter (MC) and the signal and pumps are combined with tapered fiber bundles (TFBs). The final power stage uses a LMA Yb doped SBS-suppressing fiber. A single-frequency output power of 194 W is demonstrated with optical net and slope efficiencies of 73% and 80%, respectively. Numerical simulations for the signal output power and the SBS-induced Stokes backscattered power in the 4th stage amplifier agree with the experimental results. Pulse amplifier measurements showed a 400 W peak power output that was limited by the forward output ASE. The SBS reflectivity at 400 W output was only 2.75 x 10 -4.

  17. Fission excitation function for 19F + 194,196,198Pt at near and above barrier energies

    Directory of Open Access Journals (Sweden)

    Singh Varinderjit


    Full Text Available Fission excitation functions for 19F + 194,196,198Pt reactions populating 213,215,217Fr compound nuclei are reported. Out of these three compound nuclei, 213Fr is a shell closed (N=126 compound nucleus and the other two are away from the shell closure. From a comparison of the experimental fission cross-sections with the statistical model predictions, it is observed that the fission cross-sections are underestimated by the statistical model predictions using shell corrected finite range rotating liquid drop model (FRLDM fission barriers. Further the FRLDM fission barriers are reduced to fit the fission cross-sections over the entire measured energy range.

  18. Determination of effective resonance energy for the 193Ir(n,γ)194Ir reaction by the cadmium ratio method (United States)

    Budak, Mustafa Guray; Karadag, Mustafa; Yücel, Haluk


    In this work, the effective resonance energy, Ebarr -value for the 193Ir(n,γ)194Ir reaction was measured using cadmium ratio method. A dual monitor (197Au-98Mo), which has convenient resonance properties, was employed for characterization of the irradiation sites. Then analytical grade iridium oxide samples diluted with CaCO3 to lower neutron self-shielding effect stacked in small cylindrical Teflon boxes were irradiated once with a 1 mm thick Cd cylindrical box placed in a thermalized neutron field of an 241Am-Be neutron source then without it. The activities produced in samples during 193Ir(n,γ)194Ir reaction were measured using a p-type HPGe detector γ-ray spectrometer with a 44.8% relative efficiency. The correction factors for thermal, epithermal neutron self-shielding (Gth, Gepi), true coincidence summing (Fcoi) and gamma-ray self-absorption (Fs) effects were determined with appropriate approaches and programs. Thus, the experimental Ebarr -value was determined to be 2.65 ± 0.61 eV for 193Ir target nuclide. The recent data for Q0 and FCd values for Ebarr determination were based on k0-NAA online database. The present experimental Ebarr value was calculated and compared with more recent values for Q0 and FCd for 193Ir. Additionally, the Ebarr -values was theoretically calculated from the up-to-date resonance data obtained from ENDF/B VII library using two different approaches. Since there is no experimentally determined Ebarr -value for the 193Ir isotope, the results are compared with the calculated ones given in the literature.

  19. The OsCYP19-4 Gene Is Expressed as Multiple Alternatively Spliced Transcripts Encoding Isoforms with Distinct Cellular Localizations and PPIase Activities under Cold Stress

    Directory of Open Access Journals (Sweden)

    Areum Lee


    Full Text Available Alternative splicing (AS is an important molecular mechanism by which single genes can generate multiple mRNA isoforms. We reported previously that, in Oryza sativa, the cyclophilin 19-4 (OsCYP19-4.1 transcript was significantly upregulated in response to cold stress, and that transgenic plants were cold tolerant. Here we show that, under cold stress, OsCYP19-4 produces eight transcript variants by intron retention and exon skipping, resulting in production of four distinct protein isoforms. The OsCYP19-4 AS isoforms exhibited different cellular localizations in the epidermal cells: in contrast to OsCYP19-4.1, the OsCYP19-4.2 and OsCYP19-4.3 proteins were primarily targeted to guard and subsidiary cells, whereas OsCYP19-4.5, which consists largely of an endoplasmic reticulum (ER targeting signal, was co-localized with the RFP-BiP marker in the ER. In OsCYP19-4.2, the key residues of the PPIase domain are altered; consistent with this, recombinant OsCYP19-4.2 had significantly lower PPIase activity than OsCYP19-4.1 in vitro. Specific protein-protein interactions between OsCYP19-4.2/3 and AtRCN1 were verified in yeast two-hybrid (Y2H and bimolecular fluoresence complementation (BiFC assays, although the OsCYP19-4 isoforms could not bind each other. Based on these results, we propose that two OsCYP19-4 AS isoforms, OsCYP19-4.2 and OsCYP19-4.3, play roles linking auxin transport and cold stress via interactions with RCN1.

  20. Radio monitoring of the hard state jets in the 2011 outburst of MAXI J1836-194

    CERN Document Server

    Russell, T D; Curran, P A; Soria, R; Altamirano, D; Corbel, S; Coriat, M; Moin, A; Russell, D M; Sivakoff, G R; Slaven-Blair, T J; Belloni, T M; Fender, R P; Heinz, S; Jonker, P G; Krimm, H A; Kording, E G; Maitra, D; Markoff, S; Middleton, M; Migliari, S; Remillard, R A; Rupen, M P; Sarazin, C L; Tetarenko, A J; Torres, M A P; Tudose, V; Tzioumis, A K


    MAXI J1836-194 is a Galactic black hole candidate X-ray binary that was discovered in 2011 when it went into outburst. In this paper, we present the full radio monitoring of this system during its `failed' outburst, in which the source did not complete a full set of state changes, only transitioning as far as the hard intermediate state. Observations with the Karl G. Jansky Very Large Array (VLA) and Australia Telescope Compact Array (ATCA) show that the jet properties changed significantly during the outburst. The VLA observations detected linearly polarised emission at a level of ~1% early in the outburst, increasing to ~3% as the outburst peaked. High-resolution images with the Very Long Baseline Array (VLBA) show a ~15 mas jet along the position angle $-21 \\pm 2^\\circ$, in agreement with the electric vector position angle found from our polarisation results ($-21 \\pm 4^\\circ$), implying that the magnetic field is perpendicular to the jet. Astrometric observations suggest that the system required an asymme...

  1. Is DRE essential for the follow up of prostate cancer patients? A prospective audit of 194 patients

    Directory of Open Access Journals (Sweden)

    Matanhelia Shyam S


    Full Text Available Abstract Background Prostate cancer follow up forms a substantial part of the urology outpatient workload. Nurse led prostate cancer follow up clinics are becoming more common. Routine follow-up may involve performing DRE, which may require training. Objectives The aim of this audit was to assess the factors that influenced the change in the management of prostate cancer patients during follow up. This would allow us to pave the way towards a protocol driven follow up clinic led by nurse specialists without formal training in DRE. Results 194 prostate cancer patients were seen over a period of two months and all the patients had DRE performed on at least one occasion. The management was changed in 47 patients. The most common factor influencing this change was PSA trend. A change in DRE findings influenced advancement of the clinic visit in 2 patients. Conclusions PSA is the most common factor influencing change in the management of these patients. Nurse specialists can run prostate cancer follow-up clinics in parallel to existing consultant clinics and reserve DRE only for those patients who have a PSA change or have onset of new symptoms. However larger studies are required involving all the subgroups of patients to identify the subgroups of patients who will require DRE routinely.

  2. An evolving compact jet in the black hole X-ray binary MAXI J1836-194

    CERN Document Server

    Russell, D M; Miller-Jones, J C A; O'Brien, K; Soria, R; Sivakoff, G R; Slaven-Blair, T; Lewis, F; Markoff, S; Homan, J; Altamirano, D; Curran, P A; Rupen, M P; Belloni, T M; Bel, M Cadolle; Casella, P; Corbel, S; Dhawan, V; Fender, R P; Gallo, E; Gandhi, P; Heinz, S; Koerding, E G; Krimm, H A; Maitra, D; Migliari, S; Remillard, R A; Sarazin, C L; Shahbaz, T; Tudose, V


    We report striking changes in the broadband spectrum of the compact jet of the black hole transient MAXI J1836-194 over state transitions during its discovery outburst in 2011. A fading of the optical-infrared (IR) flux occurred as the source entered the hard-intermediate state, followed by a brightening as it returned to the hard state. The optical-IR spectrum was consistent with a power law from optically thin synchrotron emission, except when the X-ray spectrum was softest. By fitting the radio to optical spectra with a broken power law, we constrain the frequency and flux of the optically thick/thin break in the jet synchrotron spectrum. The break gradually shifted to higher frequencies as the source hardened at X-ray energies, from ~ 10^11 to ~ 4 x 10^13 Hz. The radiative jet luminosity integrated over the spectrum appeared to be greatest when the source entered the hard state during the outburst decay (although this is dependent on the high energy cooling break, which is not seen directly), even though ...

  3. M1 transitions between superdeformed states in {sup 194,195}Tl: The fingerprint of the i{sub 13/2} proton intruder orbital

    Energy Technology Data Exchange (ETDEWEB)

    Azaiez, F.; Duprat, J.; Sharpey-Schafer, J.F.; Aiche, M.; Bastin, G.; Beausang, C.W.; Bourgeois, C.; Clark, R.M.; Deloncle, I.; Duffait, R.; Gale, S.J.; Gall, B.; Hannachi, F.; Hibbert, I.; Joyce, M.J.; Kaci, A.; Kelly, W.H.; Korichi, A.; Le Coz, Y.; Meyer, M.; Perrin, N.; Poffe, N.; Porquet, M.G.; Redon, N.; Sergolle, H.; Schuck, C.; Simpson, J.; Wadsworth, R. [Inst. de Physique Nucleaire, 91 Orsay (France)]|[Oliver Lodge Lab., Univ. of Liverpool (United Kingdom)]|[C.S.N.S.M., IN2P3-CNRS, 91 Orsay (France)]|[Nuclear Structure Facility, Daresbury Lab., Daresbury, Warrington (United Kingdom)]|[Inst. de Physique Nucleaire de Lyon, IN2P3-CNRS, Univ. Claude Bernard, 69 Villeurbanne (France)]|[Dept. of Physics, Univ. of York (United Kingdom)]|[Iowa State Univ., Ames, IA (United States)]|[Univ. of Oxford, Dept. of Physics (United Kingdom)


    Recent data from the EUROGAM array have revealed dipole transitions linking signature partner superdeformed bands in {sup 194}Tl and {sup 195}Tl nuclei. Measurements of the decay branching ratios, taken together with the average quadrupole moment of the neighboring superdeformed nuclei, enable the absolute M1 strengths to be determined. From these data and using the strong coupling model, we find that two SD bands in {sup 195}Tl are due to the 81st proton being in the [642]5/2{sup +} orbital and four from the six SD bands in {sup 194}Tl correspond to a configuration where the intrinsic spins of the single proton and single neutron are aligned. (orig.).

  4. The even-even nucleus {sup 196}Hg and its relation to the ''magical quartet'' around {sup 194}Pt

    Energy Technology Data Exchange (ETDEWEB)

    Bernards, Christian; Albers, Michael; Fransen, Christoph; Heinze, Stefan; Jolie, Jan; Radeck, Desiree; Thomas, Tim [Institute for Nuclear Physics, University of Cologne (Germany)


    The investigation of {sup 196}Hg - especially the determination of level spins and multipole mixing ratios of {gamma} transitions between low-energy states - is of great interest for testing the existence of a relation between the nucleus {sup 196}Hg and the so-called magical quartet around {sup 194}Pt. Within the U{sub {nu}}(6/12) x U{sub {pi}}(6/4) extended supersymmetry, this quartet is supposed to be the supermultiplet being described the best. Similar to the quartet members {sup 194,195}Pt and {sup 195,196}Au, the nucleus {sup 196}Hg can be described theoretically by seven IBA-2 particles to the shell closure, in particular by two j = 3/2 proton fermions and five sd neutron bosons as a two-fermions - five-bosons supermultiplet member. In order to obtain experimental data on {sup 196}Hg a {gamma}{gamma} angular correlation experiment was performed at the Tandem accelerator of the Institute for Nuclear Physics in Cologne. Using a {sup 4}He beam with an energy of 28 MeV impinging a {sup 194}Pt target the reaction {sup 194}Pt({alpha}, 2n){sup 196}Hg was induced. To analyze the {gamma} decays of yrast and non-yrast {sup 196}Hg states 13 high purity germanium detectors were mounted in the Horus cube {gamma}-ray spectrometer, which allows the determination of level spins and multipole mixing ratios by the analysis of {gamma}{gamma} angular correlations. We discuss first results of the experiment.

  5. Microscopic Mechanism of the ω Variation in Moments of Inertia for the Yrast Superdeformed Bands 194T1(1a,1b)

    Institute of Scientific and Technical Information of China (English)

    YUShao-Ying; HEXiao-Tao; 等


    The variation in moments of inertia(J(1)and J(2) with rotational frequency for the superdeformed bands in odd-odd nuclei,194T1(1a,1b),is investigated by using the particle-number conserving method for treating the pairing interaction(monopole and quadrupole),The observed variations ofJ(1) and J(2) with ω are reproduced quite well in the calculation and the contributions from each major shell are clearly displayed.

  6. Microscopic Mechanism of the ω Variation in Moments of Inertia for the Yrast Superdeformed Bands 194Tl(1a, 1b)

    Institute of Scientific and Technical Information of China (English)

    YU Shao-Ying; HE Xiao-Tao; LIU Shu-Xin; ZHAO En-Guang; ZENG Jin-Yan


    The variation in moments of inertia (J(1) and J(2)) with rotational frequency for the superdeformed bandsin odd-odd nuclei, 194Tl(la,lb), is investigated by using the particle-number conserving method for treating the pairinginteraction (monopole and quadrupole). The observed variations of J(1) and J(2) with ω are reproduced quite well inthe calculation and the contributions from each major shell are clearly displayed.

  7. Synergetic Integration of Cu1.94S-ZnxCd1-xS Heteronanorods for Enhanced Visible-Light-Driven Photocatalytic Hydrogen Production. (United States)

    Chen, Yueguang; Zhao, Shu; Wang, Xian; Peng, Qing; Lin, Rui; Wang, Yu; Shen, Rongan; Cao, Xing; Zhang, Libo; Zhou, Gang; Li, Jun; Xia, Andong; Li, Yadong


    In this Communication, we present the integration of synergetic designs into high-quality, well-defined Cu1.94S-ZnxCd1-xS heteronanorods (0 ≤ x ≤ 1) for enhanced photocatalytic hydrogen evolution. These heteronanorods possess two light absorbers, intimate heterointerfaces, tunable band gaps over a wide range, and uniform one-dimensional morphology. As verified by experimental and density functional theory studies, these heteronanorods with continuous composition adjustment fully exploit the benefits of both interfacial charge separation and optimized band alignments. Even without any cocatalysts, Cu1.94S-Zn0.23Cd0.77S heteronanorods exhibit efficient hydrogen production activity (7735 μmol h(-1) g(-1)) under visible-light irradiation (λ > 420 nm), representing a 59-fold enhancement compared with the pristine CdS catalyst. Meanwhile, deposition of a Pt cocatalyst on the Cu1.94S-ZnxCd1-xS surface substantially enhances the hydrogen production performance (13 533 μmol h(-1) g(-1)) with an apparent quantum efficiency of 26.4% at 420 nm, opening up opportunities to promote the overall photocatalytic performance using rationally designed nanostructures.


    Energy Technology Data Exchange (ETDEWEB)

    Russell, D. M. [Instituto de Astrofisica de Canarias (IAC), E-38200 La Laguna, Tenerife (Spain); Russell, T. D.; Miller-Jones, J. C. A.; Soria, R.; Slaven-Blair, T.; Curran, P. A. [International Centre for Radio Astronomy Research, Curtin University, GPO Box U1987, Perth, WA 6845 (Australia); O' Brien, K. [Department of Astrophysics, University of Oxford, Keble Road, Oxford OX1 3RH (United Kingdom); Sivakoff, G. R. [Department of Physics, University of Alberta, CCIS 4-181, Edmonton, AB T6G 2E1 (Canada); Lewis, F. [Faulkes Telescope Project, University of Glamorgan, Pontypridd CF37 1DL (United Kingdom); Markoff, S.; Altamirano, D. [Astronomical Institute ' ' Anton Pannekoek' ' , University of Amsterdam, P.O. Box 94249, 1090 GE Amsterdam (Netherlands); Homan, J. [MIT Kavli Institute for Astrophysics and Space Research, 70 Vassar Street, Cambridge, MA 02139 (United States); Rupen, M. P.; Dhawan, V. [NRAO Domenici Science Operations Center, 1003 Lopezville Road, Socorro, NM 87801 (United States); Belloni, T. M. [INAF - Osservatorio Astronomico di Brera, Via E. Bianchi 46, I-23807 Merate (Italy); Cadolle Bel, M. [European Space Agency, European Space Astronomy Centre, ISOC, Villanueva de la Canada, Madrid (Spain); Casella, P. [INAF - Osservatorio Astronomico di Roma, Via Frascati 33, I-00040 Monteporzio Catone, Roma (Italy); Corbel, S. [Laboratoire AIM, UMR 7158, CEA/DSM, CNRS, Universite Paris Diderot, IRFU/SAp, Gif-sur-Yvette (France); Fender, R. P. [School of Physics and Astronomy, University of Southampton, Southampton, Hampshire SO17 1BJ (United Kingdom); Gallo, E., E-mail: [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109 (United States); and others


    We report striking changes in the broadband spectrum of the compact jet of the black hole transient MAXI J1836-194 over state transitions during its discovery outburst in 2011. A fading of the optical-infrared (IR) flux occurred as the source entered the hard-intermediate state, followed by a brightening as it returned to the hard state. The optical-IR spectrum was consistent with a power law from optically thin synchrotron emission, except when the X-ray spectrum was softest. By fitting the radio to optical spectra with a broken power law, we constrain the frequency and flux of the optically thick/thin break in the jet synchrotron spectrum. The break gradually shifted to higher frequencies as the source hardened at X-ray energies, from {approx}10{sup 11} to {approx}4 Multiplication-Sign 10{sup 13} Hz. The radiative jet luminosity integrated over the spectrum appeared to be greatest when the source entered the hard state during the outburst decay (although this is dependent on the high-energy cooling break, which is not seen directly), even though the radio flux was fading at the time. The physical process responsible for suppressing and reactivating the jet (neither of which are instantaneous but occur on timescales of weeks) is uncertain, but could arise from the varying inner accretion disk radius regulating the fraction of accreting matter that is channeled into the jet. This provides an unprecedented insight into the connection between inflow and outflow, and has implications for the conditions required for jets to be produced, and hence their launching process.


    Energy Technology Data Exchange (ETDEWEB)

    Jana, Arghajit; Debnath, Dipak; Chakrabarti, Sandip K.; Mondal, Santanu; Molla, Aslam Ali, E-mail:, E-mail:, E-mail:, E-mail:, E-mail: [Indian Center for Space Physics, 43 Chalantika, Garia St. Rd., Kolkata, 700084 (India)


    The Galactic transient X-ray binary MAXI J1836-194 was discovered on 2011 August 29. Here we make a detailed study of the spectral and timing properties of its 2011 outburst using archival data from the RXTE Proportional Counter Array instrument. The evolution of accretion flow dynamics of the source during the outburst through spectral analysis with Chakrabarti–Titarchuk’s two-component advective flow (TCAF) solution as a local table model in XSPEC. We also fitted spectra with combined disk blackbody and power-law models and compared it with the TCAF model fitted results. The source is found to be in hard and hard-intermediate spectral states only during the entire phase of this outburst. No soft or soft-intermediate spectral states are observed. This could be due to the fact that this object belongs to a special class of sources (e.g., MAXI J1659-152, Swift J1753.5-0127, etc.) that have very short orbital periods and that the companion is profusely mass-losing or the disk is immersed inside an excretion disk. In these cases, flows in the accretion disk are primarily dominated by low viscous sub-Keplerian flow and the Keplerian rate is not high enough to initiate softer states. Low-frequency quasi-periodic oscillations (QPOs) are observed sporadically although as in normal outbursts of transient black holes, monotonic evolutions of QPO frequency during both rising and declining phases are observed. From the TCAF fits, we find the mass of the black hole in the range of 7.5–11 M{sub ⊙}, and from time differences between peaks of the Keplerian and sub-Keplerian accretion rates we obtain a viscous timescale for this particular outburst, ∼10 days.

  10. An Evolving Compact Jet in the Black Hole X-Ray Binary MAXI J1836-194 (United States)

    Russell, D. M.; Russell, T. D.; Miller-Jones, J. C. A.; O'Brien, K.; Soria, R.; Sivakoff, G. R.; Slaven-Blair, T.; Lewis, F.; Markoff, S.; Homan, J.; Altamirano, D.; Curran, P. A.; Rupen, M. P.; Belloni, T. M.; Cadolle Bel, M.; Casella, P.; Corbel, S.; Dhawan, V.; Fender, R. P.; Gallo, E.; Gandhi, P.; Heinz, S.; Körding, E. G.; Krimm, H. A.; Maitra, D.; Migliari, S.; Remillard, R. A.; Sarazin, C. L.; Shahbaz, T.; Tudose, V.


    We report striking changes in the broadband spectrum of the compact jet of the black hole transient MAXI J1836-194 over state transitions during its discovery outburst in 2011. A fading of the optical-infrared (IR) flux occurred as the source entered the hard-intermediate state, followed by a brightening as it returned to the hard state. The optical-IR spectrum was consistent with a power law from optically thin synchrotron emission, except when the X-ray spectrum was softest. By fitting the radio to optical spectra with a broken power law, we constrain the frequency and flux of the optically thick/thin break in the jet synchrotron spectrum. The break gradually shifted to higher frequencies as the source hardened at X-ray energies, from ~1011 to ~4 × 1013 Hz. The radiative jet luminosity integrated over the spectrum appeared to be greatest when the source entered the hard state during the outburst decay (although this is dependent on the high-energy cooling break, which is not seen directly), even though the radio flux was fading at the time. The physical process responsible for suppressing and reactivating the jet (neither of which are instantaneous but occur on timescales of weeks) is uncertain, but could arise from the varying inner accretion disk radius regulating the fraction of accreting matter that is channeled into the jet. This provides an unprecedented insight into the connection between inflow and outflow, and has implications for the conditions required for jets to be produced, and hence their launching process. Based on observations collected at the European Southern Observatory, Chile, under ESO Program IDs 087.D-0914 and 089.D-0970.

  11. 194例甲基苯丙胺滥用者卡特尔16项人格特征分析%194 cases of methamphetamine abusers Cattell 16 Personality Characteristics

    Institute of Scientific and Technical Information of China (English)

    吴幼华; 沈慧丽; 苏俊义


    目的:探讨甲基苯丙胺(“冰毒”)滥用人员的人格特征。方法:使用卡特尔16项人格因素问卷(16PF),对194例冰毒滥用人员进行测查。结果:被调查者男性居多,为134例(69.07%)。平均年龄34.1a ± s7.5a。以初中文化程度为主,共149例(76.80%)。职业以无业者居多,为178例(91.75%)。滥用的毒品以冰毒为主,但该群体中还有部分人员滥用其他毒品,如海洛因,氯胺酮(“K 粉”)等。滥用冰毒人员在乐群性,聪慧性,恃强性,兴奋性,敢为性,敏感性,怀疑性,幻想性,世故性,忧虑性,独立性和紧张性等均显著低于中国常模,而有恒性和实验性则显著高于常模。男性滥用者在乐群性,敏感性,独立性和自律性等均显著低于女性滥用者。结论:冰毒滥用人员有其特异的人格特征,其人格明显偏离正常,男女之间存在差异。在对该人群进行脱毒治疗,管理教育,心理康复时,应充分考虑到其特异的人格特征,做到有的放矢,加强沟通和交流,做好健康教育和心理辅导,提高该群体对药物滥用的阈值,防止或减少吸毒行为的反复发生,降低复吸率。%Objective:To investigate methamphetamine(“ ice”)abuse personality traits personnel. Methods:Questionnaire Cattell 16 Personality Factor(16PF)on 194 cases of methamphetamine abuse testing personnel investigation. Results:Respondents males for 134 cases(69. 07% ). The average age 34. 1a ± s7. 5a. In junior high school education based,total 149 cases(76. 80% ). Career mostly with unemployed for 178 cases(91. 75% ). Drug abuse in methamphetamine-based,but there are some people in the population abuse other drugs,such as heroin,ketamine(“K powder”)and so on. Methamphetamine abuse in gregarious person, intelligence,aggressiveness

  12. Miocene climate as recorded on slope carbonates : examples from Malta (Central Mediterranean) and Northeastern Australia (Marion Plateau, ODP LEG 194) (United States)

    John, Cédric Michaël


    This study investigated the slope carbonates of two Miocene carbonate systems: the Maltese Islands (in the Central Mediterranean) and the Marion Plateau (Northeastern Australia, drilled during ODP Leg 194). The aim of the study was to trace the impact of the Miocene cooling steps (events Mi1-Mi6) in these carbonate systems, especially the Mi3 event, which took place around 13.6 Ma and deeply impacted the marine oxygen isotope record. This event also profoundly impacted oceanographic and climatic patterns, eventually leading to the establishment of the modern ice-house world. In particular, East Antarctica became ice covered at that period. The rational behind the present study was to investigate the impact that this event had on shallow water systems in order to complement the deep-sea record and hence acquire a more global perspective on Miocene climate change. The Maltese Islands were investigated for trends in bulk-rock carbon and oxygen isotopes, as well as bulk-rock mineralogy, clay minerals analysis and organic geochemisty. Results showed that the mid Miocene cooling event deeply impacted sedimentation at that location by changing sedimentation from carbonate to clay-rich sediments. Moreover, it was discovered that each phase of Antarctic glaciation, not just the major mid Miocene event, resulted in higher terrigenous input on Malta. Mass accumulation rates revealed that this was linked to increased runoff during periods when Antarctica was glaciated, and thus that the carbonate sediments were “diluted” by clay-rich sediments. The model subsequently developed to explain this implies feedback from Antarctic glaciations creating cold, dense air masses that push the ITCZ Northward, thus increasing precipitation on the North African subcontinent. Increased precipitation (or stronger African monsoon) accelerated continental weathering and runoff, thus bringing more terrigenous sediment to the paleo-location of the slope sediments of Malta. Spectral analysis of

  13. Mutations at positions 186 and 194 in the HA gene of the 2009 H1N1 pandemic influenza virus improve replication in cell culture and eggs

    Directory of Open Access Journals (Sweden)

    Balabanis Kara


    Full Text Available Abstract Obtaining suitable seed viruses for influenza vaccines poses a challenge for public health authorities and manufacturers. We used reverse genetics to generate vaccine seed-compatible viruses from the 2009 pandemic swine-origin influenza virus. Comparison of viruses recovered with variations in residues 186 and 194 (based on the H3 numbering system of the viral hemagglutinin showed that these viruses differed with respect to their ability to grow in eggs and cultured cells. Thus, we have demonstrated that molecular cloning of members of a quasispecies can help in selection of seed viruses for vaccine manufacture.

  14. c.194 A>C (Q65P) mutation in the LMX1B gene in patients with nail-patella syndrome associated with glaucoma (United States)

    Romero, Pablo; Sanhueza, Felipe; Lopez, Pamela; Reyes, Loreto


    Purpose To report the clinical, ophthalmic, extraophthalmic, and genetic characteristics of nail-patella syndrome (NPS) in a Chilean family and to investigate the expressivity of open angle glaucoma (OAG) and ocular hypertension (OHT) in the family members. Methods Five family members affected with NPS and two unaffected members underwent a complete ophthalmologic examination, including computerized visual field, optical coherence tomography (OCT) of the optic disc and ultrasound pachymetry. Renal function was assessed by urinalysis and blood tests. Orthopedic evaluations were also performed, including radiological studies of the wrist, elbow and hip joints. Genomic DNA was extracted from peripheral leukocytes of the five affected and two unaffected family members. Exons 2–6 of the LIM homeobox transcription factor 1-beta (LMX1B) gene were screened for mutations by DNA sequencing of the proband. We also screened for mutations in exon 2 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) of the other participants and 91 blood donors. Results Five living family members from three generations were positively diagnosed with NPS, three of them with varying degrees of OAG and one with OHT. Retinal nerve fiber layer (RNFL) thickness measured by spectral domain OCT was below normal values in three individuals. All subjects evaluated had normal nephrologic function. Orthopedic, clinical, and radiological alterations were compatible with NPS. Screening for mutations in exons 2- 6 of LMX1B showed a heterozygous missense mutation c.194 A>C changing glutamine to proline within exon 2 in codon 65 (Q65P) of the coding sequence. This mutation was present in all NPS subjects and absent in the unaffected family members and in 91 Chilean blood donors. Conclusions This is the first report of c.194 A>C mutation in LMX1B in a Chilean family with NPS and the second worldwide. The phenotype associated with this mutation is variable within the family

  15. Description of E4 Transitions in A = 192, 194,196, 198 Platinum Isotopes in a Microscopic sdgIBM- 1

    Institute of Scientific and Technical Information of China (English)

    ZHANG ZhanJun; YANG Jie; WANG Xin; LIU Yong


    Influence of the effective fermion hexadecapole force newly incorporated in a microscopic sdgIBM-1 on spectra, reduced E2 and E4 transition matrix elements (T(E2)s and T(E4)s) in the even-even platinum isotopes (A = 192,194,196,198) is investigated in terms of numerical calculations. It is found that the introduced interaction causes only limited modification to the spectrum and T(E2)s, apart from a few exceptions. However, it plays an essential role in describing E4 transitions. Thus in the case that the interaction is incorporated with certain strength, a reasonable description of all the E4 transitions in the platinum isotopes is reached in the microscopic sdgIBM-1 in comparing both to experimental data and the results calculated in phenomenological boson model.``

  16. High superionic conduction arising from aligned large lamellae and large figure of merit in bulk Cu1.94Al0.02Se (United States)

    Zhong, Bin; Zhang, Yong; Li, Weiqian; Chen, Zhenrui; Cui, Jingying; Li, Wei; Xie, Yuandong; Hao, Qing; He, Qinyu


    Good thermoelectric materials should have low thermal conductivity, high electrical conductivity, and Seebeck coefficient, which cannot be easily balanced in bulk materials. Exceptionally, the super-ionics in β-Cu2Se can favorably contribute large ionic electrical conductivity and a liquid-like thermal conductivity by Cu+ ions. In the previous work, the superionic mechanism was found to be enhanced by small and randomly orientated lamellae with alternating ordered Se ion monolayer and disordered Cu ion bilayers. Here, we further enhance the superionic mechanism by increasing and better aligning lamellae in bulk Cu1.94Al0.02Se, resulting in a large thermoelectric figure of merit of 2.62 at 756 °C.

  17. Evidenced Formal Coverage Index and universal healthcare enactment: A prospective longitudinal study of economic, social, and political predictors of 194 countries. (United States)

    Feigl, Andrea B; Ding, Eric L


    Determinants of universal healthcare (UHC) are poorly empirically understood. We undertook a comprehensive study of UHC development using a novel Evidenced Formal Coverage (EFC) index that combines three key UHC elements: legal framework, population coverage, and accessibility. Applying the EFC index measures (legislation, ≥90% skilled birth attendance, ≥85% formal coverage) to 194 countries, aggregating time-varying data from 1880-2008, this study investigates which macro-economic, political, and social indicators are major longitudinal predictors of developing EFC globally, and in middle-income countries. Overall, 75 of 194 countries implemented legal-text UHC legislation, of which 51 achieved EFC. In a country-year prospective longitudinal analysis of EFC prediction, higher GDP-per-capita (per GDP-per-capita doubling, relative risk [RR]=1.77, 95% CI: 1.49-2.10), higher primary school completion (per +20% completion, RR=2.30, 1.65-3.21), and higher adult literacy were significantly associated with achieving EFC. Results also identify a GDP-per-capita of I$5000 as a minimum level for development of EFC. GDP-per-capita and education were each robust predictors in middle-income countries, and education remained significant even controlling for time-varying GDP growth. For income-inequality, the GINI coefficient was suggestive in its role in predicting EFC (p=0.024). For social and political indicators, a greater degree of ethnic fractionalization (per +25%, RR=0.51, 0.38-0.70), proportional electoral system (RR=2.80, 1.22-6.40), and dictatorships (RR=0.10, 0.05-0.27) were further associated with EFC. The novel EFC index and this longitudinal prospective study together indicate that investment in both economic growth and education should be seen of equal importance for development of UHC. Our findings help in understanding the social and political drivers of universal healthcare, especially for transitioning countries.

  18. Superação da resistência qualitativa da cultivar de trigo "BRS 194" por uma nova raça de Puccinia triticina Breakdown of qualitative leaf rust resistance in the wheat cultivar 'BRS 194' by a new race of Puccinia triticina

    Directory of Open Access Journals (Sweden)

    Márcia Soares Chaves


    Full Text Available A população de Puccinia triticina, agente causal da ferrugem da folha do trigo, é extremamente dinâmica na região do Cone Sul da América do Sul, onde o surgimento de novas raças é freqüente. A cultivar de trigo "BRS 194" foi a segunda variedade com maior disponibilidade de sementes para plantio no Rio Grande do Sul e em Santa Catarina em 2005, por apresentar características como rusticidade, elevado rendimento de grãos e resistência qualitativa a todas as raças de P. triticina ocorrentes no Brasil e em outros países da América do Sul. Em 2005, pústulas de ferrugem da folha foram observadas sobre plantas desta cultivar, tanto em lavouras quanto em campos experimentais, indicando a possível superação de sua resistência. O objetivo deste trabalho foi identificar a raça de P. triticina presente em amostras oriundas de "BRS 194" e verificar se esta se tratava de uma nova virulência do patógeno, a qual teria superado sua resistência. Oito amostras de ferrugem provenientes da cultivar "BRS 194" foram enviadas em 2005 à Embrapa Trigo, Passo Fundo, Rio Grande do Sul, para isolamento e identificação por meio da Série Internacional de Hospedeiros Diferenciais específica para este patógeno. Todas as amostras apresentaram a mesma combinação de virulência, a qual correspondeu ao código MFP-CT, conforme o Sistema Norte-Americano de nomenclatura do patógeno. Esta foi a primeira vez que este código foi detectado no Brasil, caracterizando o surgimento de uma nova raça de P. triticina virulenta à "BRS 194". Outras cultivares de trigo, também amplamente semeadas, foram inoculadas com a nova raça, sendo que algumas foram suscetíveis e outras resistentes. Entre as cultivares resistentes estão "Fundacep 30" e "IPR 84", as quais permanecem também resistentes a todas as raças do patógeno ocorrentes no Brasil.The population of Puccinia triticina, the causal agent of wheat leaf rust, is extremely dynamic in the South Cone

  19. Photometric analysis of the structure evolution on the Pb-19.4%Sn melt surface in the S-L temperature range

    Directory of Open Access Journals (Sweden)

    Lyakhovitskii M.M.


    Full Text Available The structure evolution of alloys in solidification range is considered as the first-order phase transformation from the solid state to the liquid one, which occurs by the mechanism of nucleation and growth of more symmetrical phase to less symmetrical crystalline phase. The kinetic regularities of this transformation are studied by the method of the photometric analysis of structure images (PHASI, which makes it possible to establish the temperature dependence of the relationship between the solid and liquid phases and their distribution on the melt surface. The PHASI method is based on the combined analysis of the brightness spectra of the visible light reflections from the sample surface and of the distribution of its scattering centers in different intensity intervals. The data on the structure evolution of the Sn+19.4%Pb alloy upon melting and solidification were considered in parallel with the measured spectra of sound signals. It was revealed that a distinct maximum is observed in the temperature dependence of radiation energy in the temperature range of phase transformation from the liquid into the solid state and hot crack formation occurs near the transition zone in the region of the contact of the ingot with the crucible.

  20. Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase. (United States)

    Scaffidi, C; Volkland, J; Blomberg, I; Hoffmann, I; Krammer, P H; Peter, M E


    The adapter molecule Fas-associated death domain protein (FADD)/mediator of receptor-induced toxicity-1 (MORT1) is essential for signal transduction of the apoptosis-inducing receptor CD95 (APO-1/Fas) as it connects the activated receptor with the effector caspase-8. FADD also plays a role in embryonic development and the cell cycle reentry of T cells. FADD is phosphorylated at serine residues. We now show that phosphorylation exclusively occurs at serine 194. The phosphorylation of FADD was found to correlate with the cell cycle. In cells arrested at the G2/M boundary with nocodazole, FADD was quantitatively phosphorylated, whereas only nonphosphorylated FADD was found in cells arrested in G1/S with hydroxyurea. In this context, we have identified a 70-kDa cell cycle-regulated kinase that specifically binds to the C-terminal half of FADD. Because CD95-mediated apoptosis is independent of the cell cycle, phosphorylation of FADD may regulate its apoptosis-independent functions.

  1. Ranchero Armature Test LA-19.4-CT-3: PBX-9501 Explosive with no smoothing layer. Firing point 88, 9/16/13

    Energy Technology Data Exchange (ETDEWEB)

    Glover, Brian B. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Goforth, James H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rae, Philip John [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dickson, Peter [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Briggs, Matthew E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Marr-Lyon, Mark [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hare, Steven John [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Herrera, Dennis Harold [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Watt, Robert Gregory [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Rousculp, Christopher L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    LA-19.4-CT-3 (CT-3) was the third camera test in a series beginning in 1/11, which diagnose the performance of 6 mm thick, 6061 T-0 Al Ranchero armatures. [The test LA-43-CT-2 (CT-2) is described in LA-UR-14-21983.] The goal of CT-3 was to verify that PBX-9501, with 18 mm point spacing and no smoothing layer, could be used for Ranchero generator armatures in place of PBXN-110, which had been used in all previous Ranchero applications. CT-1 and CT-2 both had 43 cm long slapper detonator systems imbedded in the cast PBXN-110 explosive, but manufacturing a charge for a similar 9501 test was not cost effective. Instead, a single cylinder of 9501, 19.368 cm long and 15.494 cm (6.100”)in diameter, had a groove machined to accommodate a row of 11 SE-1 detonators with 18 mm point spacing along the mid-plane of the cylinder. The expansion of the armature looks like a slapper assembly along almost ½ of the circumference, and provides adequate proof of concept. Removing the smoother from PBXN-110-driven armatures increased the armature velocity from 3.1 mm/μs to 3.3 mm/μs, as seen in CT-2, and the velocity measured on CT-3 increased to 3.8 mm/μs. In addition, the camera records show that the surface of the armature is smooth enough, and free from ruptures for an expansion of greater that 2X. The advantage of using 9501 is that it precludes concerns about blow-outs seen when bubbles are left in the cast material, and gives extra velocity. The disadvantage is that the machined explosives are more expensive.

  2. DOC fluxes from the UK - up to 194 monitoring sites over 125 years and from 0.1 km2 to 10000 km2 (United States)

    Turner, E. K.; Worrall, F.; Howden, N. K.; Burt, T. P.


    Current controls on carbon biogeochemistry are poorly understood due to a lack of long-term observational data for both possible environmental drivers and terrestrial/freshwater system response. This study constructed a database for 194 catchments from across the UK where DOC export was assessed in the context of soil, land-use and hydrological characteristics of each catchment with data going back to as far as 1868. By comparing across catchments of differing sizes while allowing for differences in soil and land use this study can estimate the loss of DOC at the soil source and the losses in-stream. The study shows that, although the dominant source of DOC was organic soils, there was significant DOC export from urban and grazed land on mineral and organo-mineral soils, but not from arable land. It means that DOC loss at source can be estimated and the impact on atmospheric CO2 calculated. In a temporal rather than spatial sense records of DOC flux since 1882, show that the trend in the DOC flux is explained by changes in flow. This is associated with two factors: changes in land use, especially changes in the presence of pasture; and, catchment groundwater storage. A significant decline in the long-term DOC flux is caused by two factors: a change in land use from predominant pasture to arable land; and increasing air temperature. These results suggest that, whilst declining DOC flux from catchments with mineral soils may offset increases in DOC flux from organic soils, there is a shift in C losses to moorland catchments.

  3. The composition and distribution of metal clusters in the MoFe protein from a nifZ deletion strain (DJ 194) of Azotobacter vinelandii

    Institute of Scientific and Technical Information of China (English)

    ZHOU Huina; ZHANG Chunxi; ZHAO Ying; BIAN Shaomin; REN Fei; WANG Huangping; HUANG Jufu


    Through the anaerobic chromatography on the columns of DEAE 52, Q-Sepharose and Sephacryl S-200, a nitrogenase MoFe protein (ΔnifZ Av1) was obtained from a nifZ deleted mutant of Azotobacter vinelandii (stain DJ194). The results of Western blotting after anoxic native electrophoresis and SDS-PAGE showed that ΔnifZ Av1 was similar to wild type MoFe protein (OP Av1) at the electrophoretic mobility, molecular weight and subunit composition. Furthermore, ΔnifZ Av1 was also similar to OP Av1 at the molybdenum content, EPR signal (g≈4.3, 3.65 and 2.01), and the molar extinction coefficient (Δε) of circular dichroism (CD) at 660 nm region. All of these indicated that, besides having the same α2β2 composition as OP Av1, the ΔnifZ Av1 also contained equal amount of reductive FeMoco in the spin state of S=3/2 to OP Av1. However, the iron content and substrate (C2H2, H+ and N2)-reduction activity of ΔnifZ Av1 were 74% and 46%―50% of those of OP Av1, respectively. Furthermore, the Δε at around 450 nm, which reflects P-cluster in Av1, was obviously lower than that of OP Av1. It suggested that the difference between ΔnifZ Av1 and OP Av1 resulted from P-cluster rather than FeMoco, and from the half number of P-cluster in ΔnifZ Av1, but the composition or redox state of P-cluster in ΔnifZ Av1 were not changed. Thus it could propose that ΔnifZ Av1 is composed of two different αβ subunit pairs. One is a FeMoco- and P-cluster-containing pair, and the other is a P-cluster-deficient but FeMoco-con- taining pair. Since the deletion of nifZ gene leads to the deficiency of only one of two P-clusters in a α2β2 tetramer, the assembly of P-cluster may not simply depend on one gene product, and so a possible mechanism of NifZ is supposed here.

  4. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  5. Identification of Two Novel Anti-Fibrotic Benzopyran Compounds Produced by Engineered Strains Derived from Streptomyces xiamenensis M1-94P that Originated from Deep-Sea Sediments

    Directory of Open Access Journals (Sweden)

    Lei Feng


    Full Text Available The benzopyran compound obtained by cultivating a mangrove-derived strain, Streptomyces xiamenensis strain 318, shows multiple biological effects, including anti-fibrotic and anti-hypertrophic scar properties. To increase the diversity in the structures of the available benzopyrans, by means of biosynthesis, the strain was screened for spontaneous rifampicin resistance (Rif, and a mutated rpsL gene to confer streptomycin resistance (Str, was introduced into the S. xiamenensis strain M1-94P that originated from deep-sea sediments. Two new benzopyran derivatives, named xiamenmycin C (1 and D (2, were isolated from the crude extracts of a selected Str-Rif double mutant (M6 of M1-94P. The structures of 1 and 2 were identified by analyzing extensive spectroscopic data. Compounds 1 and 2 both inhibit the proliferation of human lung fibroblasts (WI26, and 1 exhibits better anti-fibrotic activity than xiamenmycin. Our study presents the novel bioactive compounds isolated from S. xiamenensis mutant strain M6 constructed by ribosome engineering, which could be a useful approach in the discovery of new anti-fibrotic compounds.

  6. 从《七色魇》看沈从文4O年代的创作心态%Looking into SHEN Congwen’s Creation MentaLity in the 194O s from seven Color Nightmare

    Institute of Scientific and Technical Information of China (English)



    新时期以来,对沈从文的研究大都集中于他的小说创作上,对于其散文创作,研究者们更多地把目光投向其3O年代的《湘行散记》等作品,相对忽略了他4O年代的创作。仔细研读沈从文4O年代的散文,发现这些抽象散文与他当时的心态息息相关,可以看作是他在外界痛苦、寂寞、压抑中对于自我灵魂的坚守和对生命意义的追问。由此,以《七色魇》文集为例,讨论沈从文在4O年代的创作精神。%Since the new period,the studies of SHEN Congwen are mostly focused on his novel creation. For his prose creation, the researchers paid more attention to his Xiangxing Sanji and ignored his works created in the 194Os. Through studying,it is found that the abstract prose is closely related to his state of mind,which can be seen as his holding and asking the meaning of life in the painful,lonely,depressing world. Seven Color Nightmare is taken as an example to discuss SHEN Congwen﹐s creative spirit in the 194Os.

  7. „Neue Leitbilder für den Fortschritt“ (LS 194. Ein Plädoyer für die Wiederentdeckung praktischer Weisheit als neues Leitbild in der Marktwirtschaft

    Directory of Open Access Journals (Sweden)

    Claudius Bachmann


    Full Text Available In the light of the far-reaching leadership failures and business scandals of the last decades, the question has often been raised of whether we are reaping the results of the practical application of abstract management theory which is actually counteracting a socially, environmentally, and economically sustainable market economy. In this sense, Pope Francis recently called for ‘new models of progress’ to reflect on ‘the meaning of the economy and its goals’ (LS 194. To answer these calls, I first provide an overview of the recent discourse in leadership and organizational studies that have critically scrutinized the established theories and models of mainstream business. Second, I draw on the Apostolic Exhortation Evangelii Gaudium and the Encyclical Laudato Si’ to derive the cornerstones of an ‘evangelizing approach’ to the guiding principles of management theory and practice suggested by Pope Francis. Third, to facilitate this renewal, I introduce the ancient idea of practical wisdom (prudence which has recently enjoyed a remarkable renaissance in the literature and is considered as a new transformative paradigm for management theory and practice.

  8. General energy competence in the primary law of the European Union. An analysis of Article 194 of the Treaty on the Functioning of the European Union in the Lisbon version in consideration of the historical development of energy competence; Die allgemeine Energiekompetenz im Primaerrecht der Europaeischen Union. Eine Analyse des Artikels 194 des Vertrags ueber die Arbeitsweise der Europaeischen Union in der Fassung des Vertrags von Lissabon unter Beruecksichtigung der historischen Entwicklung der Energiekompetenz

    Energy Technology Data Exchange (ETDEWEB)

    Hacklaender, Daniel


    With the coming into force of the Lisbon treaty, the internal measures and policies of the European Union were supplemented by the independent title ''Energy''. While the need for supranational management of energy-political task was recognized at an early stage already, the legal instruments for this purpose were lacking. Article 194 of the Treaty on the Functioning of the European Union now provides a legal basis for a comprehensive, interdisciplinary energy policy on a European scale. The author investigates the content of the energy article. He shows that the modification of the treaty has brought about greater competences of the Union, especially in the field of energy supply assurance which is greatly influenced by the new regulations on energy solidarity. The book also discusses problems of competing legislation resulting from interdependences between the energy article on the one hand and competence standards with other goals on the other hand and also attempts to define the specific limits of energy competence. (orig.)

  9. 21 CFR 155.194 - Catsup. (United States)


    ...) Nutritive carbohydrate sweeteners. Such sweeteners if defined in part 168 of this chapter shall be as... standard, the label may bear the alternative statement, “Below Standard in Quality—Low Consistency.”...

  10. 49 CFR 572.194 - Shoulder. (United States)


    ... spine box incline. (8) The impactor is specified in 49 CFR 572.200(a). (9) The impactor is guided, if... alignment and contact point requirements of paragraph (b)(9) of this section. (11) Allow a period of at... acceleration of the upper spine (T1) shall not be less than 17 g and not more than 22 g; (3) Peak...

  11. 40 CFR 194.2 - Definitions. (United States)


    .... Department means the United States Department of Energy. Disposal regulations means part 191, subparts B and... pursuant to section 213 of the Department of Energy National Security and Military Applications of Nuclear... operation or organization(s) to establish whether the prevailing quality management structure,...

  12. Reference: 194 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available d SUVH4 (KRYPTONITE) represent distinct subgroups of SUVH genes. Loss of SUVH1 and SUVH4 causes...s SUVH2 displays strong dosage-dependent effects. Loss of function suppresses, whereas overexpression enhances, gene silencing, cause

  13. Synthesis and electrochemical characterizations of spinel LiMn1.94MO4 (M = Mn0.06, Mg0.06, Si0.06, (Mg0.03Si0.03)) compounds as cathode materials for lithium-ion batteries (United States)

    Zhao, Hongyuan; Liu, Xingquan; Cheng, Cai; Li, Qiang; Zhang, Zheng; Wu, Yue; Chen, Bing; Xiong, Weiqiang


    The spinel LiMn1.94MO4 (M = Mn0.06, Mg0.06, Si0.06, (Mg0.03Si0.03)) compounds are successfully synthesized by citric acid-assisted sol-gel method. The crystal structures and morphologies of synthesized compounds are characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM), respectively. All the compounds possess the cubic spinel structure of LiMn2O4 with space group of Fd-3m. The electrochemical properties of synthesized compounds are investigated by galvanostatic charge-discharge test, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The results show that the Si-doping can increase the discharge capacity of LiMn2O4 due to the more expanded and regular MnO6 octahedra. In particular, for the LiMn1.94Mg0.03Si0.03O4 compound, the addition of Si4+ ions can make up for the shortage of Mg-doping in term of the discharge capacity. As a result, the Mg2+ and Si4+ co-doping has the effect of synergistic enhancement, which can make full use of the respective advantages of Mg-doping and Si-doping. The optimal LiMn1.94Mg0.03Si0.03O4 can deliver the initial discharge capacity of 128.3 mAh g-1 with good capacity retention of 92.8% after 100 cycles at 0.5 C in the voltage range of 3.20-4.35 V. Compared with the undoped LiMn2O4, the co-doped compound also presents superior rate performance, especially the capacity recovery performance.

  14. 某三级医院1194例脑出血病例统计分析%Statistical Analysis of 1 194 Cases of Patients with Cerebral Hemorrhage in Some AAA Hospital

    Institute of Scientific and Technical Information of China (English)



    Objective To know the incidence of patients with cerebral hemorrhage and provide scientific reference for the further prevention and treatment of cerebral hemorrhage. Methods 1 194 cases of patients with cerebral hemorrhage diag-nosed in our hospital were counted and analyzed by the case management system according to the national disease classifi-cation code ICD-10. Results The proportion of cerebral hemorrhage in the cerebrovascular disease in our hospital took on an increasing trend from 2010 to 2015, and the number of patients with cerebral hemorrhage obviously increased, and the proportion increased from 16.6% in 2010 to 24.3% in 2015, and the growth rate per annum of patients with cerebral hem-orrhage was 14.5%, and the proportion of male and female was 1.20:1, and the male patients were more than the female pa-tients, and the patients were mainly more than 60 years old, 787 cases in total (65.91%), and the onset time of the disease was mostly from September to February of next year, accounting for 58.3%. Conclusion The patients with cerebral hemor-rhage takes on an increasing trend in our hospital, in addition to treatment for patients with cerebral hemorrhage, various forms of health education should be adopted to popularize the preventive common knowledge of cerebral hemorrhage, advo-cate the healthy lifestyle and good dieting habits, and we should focus on the initial prevention and first-class prevention, and the elderly population (older than 50 years) is the key objects.%目的:了解脑出血患者的发病情况,为进一步预防和治疗脑出血发病提供科学参考。方法以国际疾病分类编码ICD-10为标准,采用病案管理系统对该院2010-2015年出院病案主要诊断为脑出血的1194例进行统计分析。结果2010-2015年该院脑出血在脑血管病中所占比例呈上升趋势,脑出血患者数量明显增加,构成比由2010年的16.6%增至2015年的24.3%,脑出血病人的年平均增长速度是14.5%

  15. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott


    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  16. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)


    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  17. Dicty_cDB: SFI194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available _17H10 5', mRNA sequence. 42 4e-05 3 BG711333 | ( S74728 ) antiquitin=26g turgor protein homolog [human, kid... |pid:none) Acanthopagrus schlegelii antiquiti... 223 9e-57 AY883858_1( AY883858 |pid:none) Sterkiella histriomuscorum turgor

  18. Dicty_cDB: SFF194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 124-6045772 strain AX4, complete sequence. 34 0.50 7 BE317387 |BE317387.2 NF068C10LF1F1070 Developing leaf M...249770 |BE249770.2 NF022C10LF1F1081 Developing leaf Medicago truncatula cDNA clone NF022C10LF 5', mRNA seque

  19. Cranial Defects and Cranioplasty. Part 8. Chapter 194, (United States)


    incidence of trauma through wars and vehicular accidents and multiplying neurosurgical procedures has provided an experiential base upon which prin...approximated to one another -14 5. - j 1: _J - -. 1 -. Y J 3 -* Donald J. Prolo, M.D. to stimulate osseous rather than fibrous union. Wiring adjacent ribs

  20. 40 CFR 194.55 - Results of compliance assessments. (United States)


    ...) Compliance assessments shall consider and document uncertainty in the performance of the disposal system. (b) Probability distributions for uncertain disposal system parameter values used in compliance assessments...

  1. 46 CFR 194.10-10 - Integral magazine construction. (United States)


    .... (g) Racks, stanchions, battens, and other devices shall be installed to provide rigid and safe stowage of explosives in their approved shipping containers with a minimum of dunnage. (h) Decks shall...

  2. Dicty_cDB: SFE194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available .26 Human DNA sequence *** SEQUENCING IN PROGRESS *** from clone RP11-368H14. 363 0.0 15 AF419983 |AF419983.1 Closterium calo...sporum var. calosporum 26S ribosomal RNA gene, partial sequence. 406 0.0 9 AF419986 |AF4199...genic spacer, partial sequence. 406 0.0 9 AF419996 |AF419996.1 Closterium calosporum var. himalayense 26S ri

  3. 49 CFR Appendix B to Part 194 - High Volume Areas (United States)



  4. 49 CFR 194.107 - General response plan requirements. (United States)


    ... management system including the functional areas of finance, logistics, operations, planning, and command. The plan must demonstrate that the operator's response management system uses common terminology...

  5. Dicty_cDB: CHO194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available er of HSP's gapped (non-prelim): 0 length of query: 121 length of database: 80,480,566 effective HSP length: 17 effective... length of query: 104 effective length of database: 78,821,179 effective search space: 8197402616 effective...successful extensions: 0 Number of sequences better than 10.0: 0 length of query: 121 length of database: _,504,085,797 effective... HSP length: 21 effective length of query: 100 effective length of database: ^,543,142,933 effective... search space: 4654314293300 effective search space used: 4654314293300 T: 0 A: 0 X1: 6 (11.9 b

  6. Dicty_cDB: AFF194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available gsncitkttrktktdgirdskrirkissrrsrc*rkyr l*s*rkektrri*kenagktk*skrcsktknt*r*rkrkn*irktkrkrstkrinetsne wck*w*it...All Frames) Frame A: ttttnrgdnittnik***i*ktgsncitkttrktktdgirdskrirkissrrsrc*rkyr l*s*rkektrri*kenagktk*skrcskt

  7. 27 CFR 26.194 - Detention of articles. (United States)


    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Detention of articles. 26..., DEPARTMENT OF THE TREASURY LIQUORS LIQUORS AND ARTICLES FROM PUERTO RICO AND THE VIRGIN ISLANDS Shipment of... Detention of articles. (a) Upon receiving a notification in accordance with § 26.193(b), the appropriate...

  8. Dicty_cDB: CFC194 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available equences producing significant alignments: (bits) Value N AF305060 |AF305060.1 Dictyostelium discoideum Wiscott...nts: (bits) Value AF305060_1( AF305060 |pid:none) Dictyostelium discoideum Wiscott

  9. 云南省1194名接受HAART的艾滋病病人的生命质量测评及影响因素分析%Quality of life and related factors among 1 194 AIDS patients receiving HAART in Yunnan province

    Institute of Scientific and Technical Information of China (English)

    王晓锋; 王启林; 杨霞


    目的 探讨接受高效抗反转录病毒治疗(HAART)的艾滋病病人的生命质量及其影响因素.方法 采取典型抽样的方法,使用中文版SF 36量表和自编基本情况调查表,对研究对象进行横断面调查,应用Epi Data 3.1建立数据库,SPSS 12.0进行统计分析.结果 选择1个省级、2个州级、5个县级抗病毒治疗医院作为研究现场,选择在2009年4月以前在8个研究现场入组并接受抗病毒治疗的艾滋病病人作为研究对象.①1 194名调查对象,SF 36量表8个领域百分转换得分中,躯体功能(PF)得分最高(86.00±18.48),总健康(GH)得分最低(44.37±21.59),领域间得分差异有统计学意义(P<0.01).②女性病人的GH、肌体疼痛(BP)维度得分高于男性病人(P<0.05);不同年龄的病人在PF、GH 2个领域的得分差异有统计学意义(P<0.05),年龄小的病人PF、GH得分高于年龄大的病人;不同文化程度的病人的PF、生命力(VT)、情感角色(RE)、心理健康(MH)、BP得分差异有统计学意义(P<0.05),文化程度低的病人以上领域得分低于文化程度高的病人;不同婚姻状况的病人生命质量8个领域得分差异均有统计学意义(P<0.05),已婚病人生命质量好于未婚和离异/独居/分居病人;农村户籍的调查对象的PF、GH、社会功能(SF)3个维度得分明显高于城镇户籍的调查对象(P<0.05);不同职业的病人生命质量8个领域得分差异均有统计学意义(P<0.05),公职人员、个体从业人员的生命质量好于无业人员和农民.结论 性别、年龄、文化程度、婚姻状况、户籍、职业是影响高效抗反转录病毒治疗艾滋病病人生命质量的因素.%Objective To investigate the quality of life and related factors among AIDS patients receiving highly active antiretroviral therapy(H AART) . Methods One provincial-level , two prefecture-level and five county-level HAART hospitals were selected as research sites by

  10. Evaluation of Novel Wet Chemistry Separation and Purification Methods to Facilitate Automation of Astatine-­211 Isolation

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott [Univ. of Washington, Seattle, WA (United States)


    This research is a collaborative effort between the research groups of the PIs, Dr. D. Scott Wilbur in the Department of Radiation Oncology at the University of Washington (UW) and Matthew O’Hara at the Pacific Northwest National Laboratory (PNNL). In this report only those studies conducted at UW and the budget information from UW will be reported. A separate progress and financial report will be provided by PNNL. This final report outlines the experiments (Tasks) conducted and results obtained at UW from July 1, 2013 thru June 30, 2016 (2-­year project with 1 year no-­cost extension). The report divides the information on the experiments and results obtained into the 5 specific objectives of the research efforts and the Tasks within those objectives. This format is used so that it is easy to see what has been accomplished in each area. A brief summary of the major findings from the studies is provided below. Summary of Major Findings from Research/Training Activities at UW: Anion and cation exchange columns did not provide adequate 211At capture and/or extraction results under conditions studied to warrant further evaluation; PEG-­Merrifield resins containing mPEG350, mPEG750, mPEG2000 and mPEG5000 were synthesized and evaluated; All of the mPEG resins with different sized mPEG moieties conjugated gave similar 211At capture (>95%) from 8M HCl solutions and release with conc. NH4OH (~50-­80%), but very low quantities were released when NaOH was used as an eluent; Capture and release of 211At when loading [211At]astatate appeared to be similar to that of [211At]astatide on PEG columns, but further studies need to be conducted to confirm that; Capture of 211At on PEG columns was lower (e.g. 80-­90%) from solutions of 8M HNO3, but higher capture rates (e.g. 99%) can be obtained when 10M HNO3 is mixed with an equal quantity of 8M HCl; Addition of reductants to the 211At solutions did not appear to change the percent capture, but may have an effect on the % extracted; There was some indication that the PEG-­Merrifield resins could be saturated (perhaps with Bi) resulting in lower capture percentages, but more studies need to be done to confirm that; A target dissolution chamber, designed and built at PNNL, works well with syringe pumps so it can be used in an automated system; Preliminary semi-­automated 211At isolation studies have been conducted with full scale target dissolution and 211At isolation using a PEG column on the Hamilton automated system gave low overall recoveries, but HNO3 was used (rather than HCl) for loading the 211At and flow rates were not optimized; Results obtained using PEG columns are high enough to warrant further development on a fully automated system; Results obtained also indicate that additional studies are warranted to evaluate other types of columns for 211At separation from bismuth, which allow use of HNO3/HCl mixtures for loading and NaOH for eluting 211At. Such a column could greatly simplify the overall isolation process and make it easier to automate.

  11. KN194L05: WHOI cruise 194 leg 05 aboard the R/V Knorr from 2008-11-01 - 2008-11-14 (NODC Accession 0080960) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Post-cruise download of raw data from shipboard computer(s) as furnished by the Woods Hole Oceanographic Institution Shipboard Scientific Support Group and archived...

  12. Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

    Energy Technology Data Exchange (ETDEWEB)

    Green, Damian J.; Shadman, Mazyar; Jones, Jon C.; Frayo, Shani; Kenoyer, Aimee L.; Hylarides, Mark; Hamlin, Donald K.; Wilbur, D. Scott; Balkan, Ethan R.; Lin, Yukang; Miller, Brian W.; Frost, Sophia; Gopal, Ajay K.; Orozco, Johnnie J.; Gooley, Ted; Laird, Kelley L.; Till, B. G.; Back, Tom; Sandmaier, B. M.; Pagel, John M.; Press, Oliver W.


    Alpha emitting radionuclides release a large amount of energy within a few cell diameters and may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD) conditions in which micrometastatic disease satellites are broadly distributed. To evaluate this hypothesis, 211At conjugated 1F5 mAb (anti-CD20) was studied in both bulky lymphoma tumor xenograft and MRD animal models. Superior treatment responses to 211At conjugated 1F5 mAb were evident in the MRD setting. Lymphoma xenograft tumor bearing animals treated with doses of up to 48µCi of anti-CD20 211At-decaborate [211At-B10-1F5] experienced modest responses (0% cures but 2-3-fold prolongation of survival compared to negative controls). In contrast, 70% of animals in the MRD lymphoma model demonstrated complete eradication of disease when treated with 211At-B10-1F5 at a radiation dose that was less than one-third (15 µCi) of the highest dose given to xenograft animals. Tumor progression among untreated control animals in both models was uniformly lethal. After 130 days, no significant renal or hepatic toxicity is observed in the cured animals receiving 15 µCi of 211At-B10-1F5. These findings suggest that in a MRD lymphoma model, where isolated cells and tumor microclusters prevail, α-emitters may be uniquely efficacious.

  13. Environmentally Sustainable Yellow Smoke Formulations for Use in the M194 Hand Held Signal (United States)


    the firing pin in the palm of the hand, an initiating charge burns to ignite the rocket propellant and a delay element, sending the signal assembly... Nitrocellulose (NC) was purchased from Alliant Techsystems, Inc. Magnesium carbonate was obtained from Pine Bluff Arsenal (Pine Bluff, AR). All...the binder system of the BES formulation with nitrocellulose (NC, formulation A) or polyvinyl alcohol (PVA, formulation B). Formulation C is a





    Diariamente, las industrias textiles descargan grandes volúmenes de aguas que contienen altas concentraciones de colorantes y aditivos, los cuales ocasionan daños considerables al medio ambiente. Muchos de estos colorantes son estables a la luz y a la biodegradación, siendo considerados como compuestos orgánicos persistentes (COPs). Es por esto que es necesario aplicar métodos que permitan la eliminación de estos contaminantes desde las aguas. Una metodología efectiva para la eliminación de C...

  15. Biological control with Trichogramma pretiosum increases organic maize productivity by 19.4%


    de Lourdes Corrêa Figueiredo, Maria; Cruz, Ivan; da Silva, Rafael Braga; Foster, John Edward


    International audience; AbstractSpodoptera frugiperda is a major pest causing maize yield loss in Brazil. There is therefore a need for control methods, notably for organic farming because classical pesticides are not allowed. A potential solution for organic maize is to apply the biological control agent Trichogramma pretiosum to reduce S. frugiperda populations. Here, we tested the application of one, two, or three releases of T. pretiosum. We measured plant damage ratings, egg masses paras...

  16. 19 CFR 19.4 - CBP and proprietor responsibility and supervision over warehouses. (United States)


    ...) Maintain the inventory control and recordkeeping system in accordance with the provisions of § 19.12 of... shall be received in the warehouse and recorded in the proprietor's inventory and accounting records... the warehouse if the proprietor's inventory control system specifically identifies all locations...

  17. 10 CFR Appendix C to Part 20 - Quantities 1 of Licensed Material Requiring Labeling (United States)


    ... Polonium-205 1,000 Polonium-207 1,000 Polonium-210 0.1 Astatine-207 100 Astatine-211 10 Radon-220 1 Radon-222 1 Francium-222 100 Francium-223 100 Radium-223 0.1 Radium-224 0.1 Radium-225 0.1 Radium-226...

  18. 76 FR 194 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating... (United States)


    ...; South Korean won) and U.S. dollar-denominated Fixed Income Securities. For purposes of this proposed... Equities Rule 9.2(a), which imposes a duty of due diligence on its ETP Holders to learn the essential...

  19. 77 FR 194 - Federal Acquisition Regulation; Time-and-Materials and Labor-Hour Contracts for Commercial Items (United States)


    ... material; (4) Clarify contract types; (5) Potential for rule to limit the use of T&M contracts; (6...) The ordering activity shall specify the order type (i.e., firm-fixed price, time- and-materials, or... RIN 9000-AL74 Federal Acquisition Regulation; Time-and-Materials and Labor-Hour Contracts...

  20. Il corpo della cittadina. La costruzione del discorso pubblico sulla legge n. 194/1978 in Italia negli anni Settanta.



    In un arco temporale che copre il decennio settanta, ma che si spinge fino ad analizzare anche il dibattito italiano odierno, la presente ricerca ricostruisce i passaggi attraverso i quali l’aborto, da pratica clandestina, è diventato un “fatto” che ha creato e cambiato l’opinione pubblica italiana. Non si tratta di una ricostruzione cronologica pura e semplice, ma quello che si propone è un percorso che procede per temi, utilizzando una particolare chiave di lettura delle fonti giornalistich...

  1. The quasicontinuum of gamma rays from the feeding and decay of the superdeformed in {sup 194}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Lauritsen, T.; Ahmad, I.; Carpenter, M.P. [and others


    Over the last year we developed techniques for the study of the quasicontinuum of gamma-rays from both the feeding and especially the decay of the superdeformed (SD) bands in the Hg nuclei, most notably {sup 192}Hg. From this analysis we could extract both the spin and energy of some of the SD bands. The quasicontinuum analysis is the only technique so far that could extract these two fundamental properties of the now more than 100 SD bands found in the A = 150 and A = 190 regions. We based our understanding of the feeding and decay on comparisons of the data with extensive Monte Carlo simulations of the emission of gamma rays, both from the entry distribution toward the SD minimum, and, at lower spins, from the decay out of the SD band back to the states in the normal well.

  2. 75 FR 54921 - Withdrawal of Regulatory Guides 1.38, 1.94, and 1.116 (United States)


    ....38 endorses the American Society of Mechanical Engineers (ASME) American National Standard Institute... endorses the ASME/ANSI Standard N45.2.5-- 1974, ``Supplementary Quality Assurance Requirements for... ASME/ANSI Standard N45.2--1975, ``Supplementary Quality Assurance Requirements for...

  3. 9 CFR 381.194 - Transportation and other transactions concerning dead, dying, disabled, or diseased poultry, and... (United States)



  4. The dietary nutriture survey on 194 old male residents in Chenggong district of Kunming The dietary nutriture survey on 194 old male residents in Chenggong district of Kunming%昆明市呈贡区194例老年男性居民膳食营养状况调查

    Institute of Scientific and Technical Information of China (English)

    肖文娜; 张雪辉; 李鹏飞; 柏桦; 王琦


    [目的]通过调查云南省昆明市呈贡区老年男性居民摄入食物的种类和数量,了解当地居民的营养状况以及膳食习惯。[方法]选取云南省昆明市呈贡区50岁以上的部分老年男性居民,采用食物频率问卷(FFQ)进行调查。[结果]经统计分析,并与中国营养学会推荐的标准进行比较,云南昆明呈贡区老年男性居民的蛋白质、热能、VC 及Fe的摄入量偏高,膳食纤维、VB1、VB2和Ca的摄入量不足。饱和脂肪酸、单不饱和脂肪酸、多不饱和脂肪酸之比(S:M:P)为1:1.35:1.26,脂肪酸构成比例不平衡。[结论]当地居民应减少肉类的摄入量,增加乳制品等含钙丰富的食物摄入,适量增加谷类食物中粗粮以及果蔬的摄入量,合理膳食,提高健康水平。%objective To know the dietary nutriture and food habit of elderly male residents in Chenggong district of Kunming through investigating their food variety and quantity.Methods Chose some male residents above 50 years old. Investigated them by food frequency questionnaire (FFQ).Results Through statistical analysis, which combined with the standard what recommended by Chinese Nutrition Society. It showed that intake of the nutrients include protein、energy、VC and Fe were shortage. The ratio of saturated fatty acid, monouns saturated fatty acid and polyun saturated fatty acid was 1:1.35:1.26. The component ratio was unbalance. Conclusions Local residents should limit the total intake of meat, increase the intake of dairy products which include calcium, and reasonable increase the intake of coarse food grain, fruit and vegetable, so as to improve health level.

  5. Hepatitis B virus in tenofovir-naive Chinese patients with chronic hepatitis B contains no mutation of rtA194T conferring a reduced tenofovir susceptibility

    Institute of Scientific and Technical Information of China (English)

    LIU Yan; WANG Chun-mei; CHENG Jun; LIANG Zhao-ling; ZHONG Yan-wei; REN Xiao-qiang; XU Zhi-hui; Fabien Zoulim; XU Dong-ping


    @@ Recently the Chinese Ministry of Health declared that 93 million people were chronically infected with hepatitis B virus (HBV) in China. Four nucleotide analogues (Nas) are currently approved for the treatment of HBV infection, I.e., lamivudine (LAM), adefovir (ADV), entecavir (ETV), and telbivudine (L-dT).1 In contrast to therapeutic benefits, prolonged use of Nas increases the emergence of drug-resistant mutations in the HBV reverse transcriptase (RT) domain, leading to a.

  6. Search for shape coexistence in {sup 188,190}Pb via fine structure in the alpha decay of {sup 192,194}Po

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, I.; Davids, C.; Janssens, R.V.F. [and others


    The interaction between coexisting shapes in nuclei near closed shells was of great interest in the past decade. Excited 0{sup +} states at low energy can often be identified as the bandheads of structures with differing shapes built on those states, These structures were identified in {sup 190-198}Pb via beta decay and alpha decay {open_quotes}fine structure{close_quotes} studies. Coexistence of different shapes in Pb nuclei was predicted by Nilsson-Strutinsky calculations, in which both the oblate and prolate minima were predicted to have excitation energies near 1 MeV. It was our intention to continue the systematic study of the Pb nuclides by searching for excited O{sup +} states in {sup 188}Pb by observing the fine structure in the alpha decay of {sup 192}Po.

  7. A Recessive Mutation Resulting in a Disabling Amino Acid Substitution (T194R) in the LHX3 Homeodomain Causes Combined Pituitary Hormone Deficiency


    Bechtold-Dalla Pozza, Susanne; Hiedl, Stefan; Roeb, Julia; Lohse, Peter; Malik, Raleigh E.; Park, Soyoung; Duran-Prado, Mario; Rhodes, Simon J.


    Background/Aims: Recessive mutations in the LHX3 homeodomain transcription factor gene are associated with developmental disorders affecting the pituitary and nervous system. We describe pediatric patients with combined pituitary hormone deficiency (CPHD) who harbor a novel mutation in LHX3. Methods: Two female siblings from related parents were examined. Both patients had neonatal complications. The index patient had CPHD featuring deficiencies of GH, LH, FSH, PRL, and TSH, with later onset ...

  8. Investigative study of a diode-pumped continuous-wave Tm:YAP laser as an efficient 1.94 μm pump source (United States)

    Kwiatkowski, Jacek; Zendzian, Waldemar; Jabczynski, Jan K.


    A detailed study of a Tm:YAP laser in continuous-wave (CW), single-pass end-pumped by a 793 nm diode laser is presented. The laser based on c-cut 3 at. % Tm:YAP crystal was experimentally examined and presented in the dependence on transmittance and radius of curvature of output coupling mirrors. A detailed spectral analysis was presented. The influence of a heat-sink cooling water temperature on the laser performance was studied. At room temperature, for an output coupling transmission of 19.5%, the maximum CW output power of 4.53 W was achieved, corresponding to a slope efficiency of 41.5% and an optical-to-optical conversion efficiency of 25.7% with respect to the incident pump power, respectively. We have shown that the output spectrum at a certain wavelength (e.g. 1940 nm) for a given pump power can be realized via the change of resonator parameters (OC transmittance, mode size).

  9. 22 CFR Appendix A to Part 194 - Inter-American Commercial Arbitration Commission Rules of Procedure (As Amended April 1, 2002) (United States)


    ... costs of such measures. 3. A request for interim measures addressed by any party to a judicial authority... stipulate resolution of such disputes pursuant to the IACAC Rules of Procedure and that have not...

  10. Sixty Percent of Coös Youth Report Having a Mentor in Their Lives. Paper 194. New Hampshire and New England Fact Sheet No. 8 (United States)

    Scovill, Kent; Tucker, Corinna Jenkins


    In this brief, authors Kent Scovill and Corinna Jenkins Tucker describe Coös youths' mentor relationships using data from the Carsey Institute's Coös Youth Study collected in 2007. They report that, in 2007, a majority of Coös youth in seventh and eleventh grade (60.2 percent) report having a mentor. In addition, 68 percent of Coös youths' mentors…

  11. Synthesis and structural characterization of Lindqvist type mixed-metal cluster anion [V2W4O19]4- in discrete and coordination polymer compounds (United States)

    Yerra, Sridevi; Amanchi, Srinivasa Rao; Das, Samar K.


    Two vanadium substituted Lindqvist type tungsten heteropolyanion containing compounds with molecular formulae [HMTAH]2[H2V2W4O19]·4H2O (1) and [Na2(H2O)4]n[H2V2W4O19]n·2nHMTA·2nH2O (2) have been synthesized, where HMTA is hexamethylenetetramine. Compound 1 is a discrete compound, whereas, compound 2 is a coordination polymer. Compounds 1-2 are characterized by routine elemental analyses, FT-IR spectroscopy, electronic absorption spectral analyses, thermogravimetric studies and single crystal X-ray crystallography. The presence of vanadium in the cluster anion is confirmed by 51V NMR spectroscopy, EDS and ICP analyses. The crystal structures of compounds 1 and 2 are refined in orthorhombic space group Immm and monoclinic space group C2/c respectively.

  12. Uso de drogas entre anestesiologistas no contexto das relações de trabalho -doi:10.5020/18061230.2008.p194


    Marcelo Niel; Alessandra Maria Julião; Denise Martin; Dartiu Xavier da Silveira Filho


    Objetivo: Compreender o uso de drogas por médicos anestesiologistas, tendo como enfoque o contexto das relações de trabalho. Métodos: Tratou-se de pesquisa qualitativa fenomenológica. Os dados foram coletados a partir da realização de entrevistas em profundidade com quinze sujeitos médicos anestesiologistas. Realizou-se a análise do conteúdo das entrevistas a partir da organização em categorias relevantes aos temas, como a constatação do uso de drogas no contexto da profissão, o acesso facili...

  13. Effects of Simvastatin on Ion Channel Currents in Ventricular Myocytes from Acute Infarcted Heart of Normocholesterolemic Rabbits

    Institute of Scientific and Technical Information of China (English)

    Chao Ding; Xianghua Fu; Li Yang; Huixiao Chen; Junxia Li; Yuying Zhao; Jie Li; Jie Wang


    Objectives To investigate the effects of simvastatin on membrane ionic currents in left ventricular myocytes of rab-bit heart suffering from acute myocardial infarction (AMI), so as to explore the ionic mechanism of statin treatment for antiarrhythmia. Methods Forty-five New Zealand rabbits were randomly divided into three groups: AMI group, simv-astatin intervention group (Statin group) and sham-operated control group (CON). Rabbits were infarcted by ligation of the left anterior descending coronary artery after administration of oral simvastatin 5 mg · kg-1 · d-1 (Statin group) or placebo (AMI group) for 3 days. Single ventricular myocytes were isolated enzymatically from the epicardial zone of the infracted region 72 h later. Whole cell patch clamp technique was used to record membrane ionic currents, inclu-ding sodium current (Ina), L-type calcium current (Ica-L) and transient outward potassium current (Ito). Results ① There was not significant difference in serum cholesterol concentration among three groups. ② The peak Ina current den-sity (at -30 mV) was significantly decreased in AMI group (-25.26±5. 28, n = 13), comparing with CON (-42. 78±5.48, n = 16), P < 0. 05, while it was significantly increased in Statin group (-39. 83±5. 65 pA/pF, n = 12) comparing with AMI group, P <0. 01; The peak I Ca-L current density (at 0 mV) was significantly decreased in AMI group (- 3.43±0. 92 pA/pF, n = 13) comparing with CON (- 4. 56±1.01 pA/pF, n = 15), P < 0. 05, while it was significantly increased in Statin group (-4. 18±0. 96 pA/pF, n = 12) comparing with AMI group, P <0. 05; The Ito current density (at + 60 mV) was significantly decreased in AMI group (11.41±1.94 pA/pF, n = 13) compa-ring with CON (17. 41±3. 13 pA/pF, n = 15), P <0. 01, while it was significantly increased in Statin group (16. 11±2. 43 pA/pF, n = 14) comparing with AMI group, P < 0. 01. Conclusions AMI induces significant down-regula-tion of Ina, I Ca-L and Ito. Pretreatment with

  14. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;


    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity...

  15. Successful radioimmunotherapy of established syngeneic rat colon carcinoma with 211At-mAb

    DEFF Research Database (Denmark)

    Eriksson, Sophie E; Bäck, Tom; Elgström, Erika


    Most carcinomas are prone to metastasize despite successful treatment of the primary tumor. One way to address this clinical challenge may be targeted therapy with α-emitting radionuclides such as astatine-211 (211At). Radioimmunotherapy utilizing α-particle emitting radionuclides is considered...... colon carcinoma with tumor diameters of approximately 10 mm....

  16. Multibeam collection for KN194-04: Multibeam data collected aboard Knorr from 2008-10-03 to 2008-10-31, departing from Reykjavik, Iceland and returning to Reykjavik, Iceland (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  17. Multibeam collection for KN194-02: Multibeam data collected aboard Knorr from 2008-09-01 to 2008-09-23, departing from Nuuk (Godthab), Greenland and returning to Nuuk (Godthab), Greenland (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  18. The Bolocam Galactic Plane Survey. X. A Complete Spectroscopic Catalog of Dense Molecular Gas Observed toward 1.1 mm Dust Continuum Sources with 7.5 <= l <= 194 degrees

    CERN Document Server

    Shirley, Yancy L; Svoboda, Brian; Schlingman, Wayne M; Ginsburg, Adam; Rosolowsky, Erik; Gerner, Thomas; Mairs, Steven; Battersby, Cara; Stringfellow, Guy; Dunham, Miranda K; Glenn, Jason; Bally, John


    The Bolocam Galactic Plane Survey (BGPS) is a 1.1 mm continuum survey of dense clumps of dust throughout the Galaxy covering 170 square degrees. We present spectroscopic observations using the Heinrich Hertz Submillimeter Telescope of the dense gas tracers, HCO+ and N2H+ 3-2, for all 6194 sources in the Bolocam Galactic Plane Survey v1.0.1 catalog between 7.5 0.5 K) without HCO+ 3-2 emission does not occur in this catalog. We characterize the properties of the dense molecular gas emission toward the entire sample. HCO+ is very sub-thermally populated and the 3-2 transitions are optically thick toward most BGPS clumps. The median observed line width is 3.3 km/s consistent with supersonic turbulence within BGPS clumps. We find strong correlations between dense molecular gas integrated intensities and 1.1 mm peak flux and the gas kinetic temperature derived from previously published NH3 observations. These intensity correlations are driven by the sensitivity of the 3-2 transitions to excitation conditions rathe...

  19. Preparing Children for Schools and Schools for Children. Notes, Comments = Preparer les enfants a l'ecole et adapter l'ecole aux enfants. Notes, Comments--No. 194. (United States)

    United Nations Children's Fund, New York, NY.

    This paper critically examines evaluations of the effects of early childhood development programs in Third World countries. Introductory comments underscoring the importance of preschool interventions for the improvement of primary schools are followed by a section explaining the paper's analytical framework, which posits an interactive…

  20. Ana Hours et Jean-Pierre Piéchaud (coord., 2010, Penser la métropole parisienne, Plaidoyer pour un projet citoyen, égalitaire et postcarbone, L’Harmattan-Les Editions des Recollets, 194 p.

    Directory of Open Access Journals (Sweden)

    Jacques Stambouli


    Full Text Available Comment penser la métropole, dans le cas de l’agglomération parisienne ? Comment y penser un développement urbain durable ? L’association 4D, dans le cadre de l’Encyclopédie du développement durable (, a choisi de rassembler sur ces sujets 19 contributions, venant principalement d’acteurs de terrain, responsables politiques ou administratifs, techniciens, membres d’associations. En conclusion, l’association propose une synthèse, parmi les pistes à suivre les plus stimu...

  1. Sp ectroscopy of Low-lying States in Odd-Z Odd-A Nuclei Beyond Lead

    Institute of Scientific and Technical Information of China (English)

    U Jakobsson; S Juutinen; A Herzan; J Konki; M Leino; M Mallaburn; J Pakarinen; P Papadakis; J Partanen; P Rahkila; M Sandzelius; J Uusitalo; J Saren; C Scholey; J Sorri; S Stolze; K Auranen; H Badran; B Cederwall; D M Cox; T Grahn; P T Greenlees; R Julin


    Low-lying states in odd-Z odd-mass nuclei at the proton drip-line beyond lead have recently been studied through fusion-evaporation reactions using a gas-filled recoil separator. Isomeric 1/2+ and 13/2+ states have been observed in odd-mass astatine and francium nuclei. The systematic behaviour of the level energies of these states have been studied and a similarity between the 1/2+ state in astatine and francium has been found. Furthermore, the 13/2+ state has been observed in the francium nuclei with an oblate behaviour suggesting a coupling of the i13/2 proton to the 2p−2h intruder excitation.

  2. Two-component relativistic density-functional calculations of the dimers of the halogens from bromine through element 117 using effective core potential and all-electron methods. (United States)

    Mitin, Alexander V; van Wüllen, Christoph


    A two-component quasirelativistic Hamiltonian based on spin-dependent effective core potentials is used to calculate ionization energies and electron affinities of the heavy halogen atom bromine through the superheavy element 117 (eka-astatine) as well as spectroscopic constants of the homonuclear dimers of these atoms. We describe a two-component Hartree-Fock and density-functional program that treats spin-orbit coupling self-consistently within the orbital optimization procedure. A comparison with results from high-order Douglas-Kroll calculations--for the superheavy systems also with zeroth-order regular approximation and four-component Dirac results--demonstrates the validity of the pseudopotential approximation. The density-functional (but not the Hartree-Fock) results show very satisfactory agreement with theoretical coupled cluster as well as experimental data where available, such that the theoretical results can serve as an estimate for the hitherto unknown properties of astatine, element 117, and their dimers.

  3. Defense Infrastructure: Department of Defense Renewable Energy Initiatives (United States)


    AZ Solar PV (Bldg 1958) Clearwell Solar Photovoltaic Fully Operational May-10 No 2010 194 $ 448 $ 448 Appropriated 303...Dept Navy MCAS Yuma AZ Solar PV (Bldg 1958) Clearwell 194 194 Limited Contributes Contributes Contributes Contributes 303 Dept Navy MCAS Yuma AZ Solar

  4. Niels Bohr and China (II) A Collection of Related Historical Materials (194%2012)%尼耳斯·玻尔与中国(下) 有关历史资料汇编(1949-2012)

    Institute of Scientific and Technical Information of China (English)



    Niels Bohr was very warm to new China and Chinese people since the establishment of the People' s Republic of China in 1949. In contrast, the Chinese scientific community also paid great respect to him in due time. Mr. Guo Moruo, for example, the first President of the Chinese Academy of Sciences, used to invite Bohr to visit China in 1957. However, since 1952, influenced by the Soviet Union and guided by Marxism ideological concepts, the Chinese academia had improperly animadverted on Bohr' s philosophical views. Even in the 1970s, while the Soviet academia had changed their attitude to Bohr, a few critical articles were still published in two radical Chinese journals during the last stage of the Cultural Revolution. On the other hand, when Bohr died in 1962, the Chinese scientific community sent messages of condolence to his family. From 1962 to 1995, nearly 40 Chinese scholars had visited the Niels Bohr Institute at Copenhagen. In 1985, on the occasion of the 100th anniversary of Bohr' s birth, Chinese physics community held a ceremonious commemoration, singing high praise for this great scientist. Professor Ge Ge devoted all his life to introduce Bohr and his works into China, in particular by translating total 12 volumes of his Collected Works. In the 21 st century, although the political critique on Bohr' s philosophy in China has no long existed, the evaluation about Bohr, the Copenhagen School, as well as his view of the principle of complementarity, are still the most attractive topics which may cause continual and enthusiastic discussion.%1949年以后,中华人民共和国成立,玻尔一直对新中国和中国人民友好。中国科学界也一直尊敬、仰慕玻尔。1957年中国科学院院长郭沫若曾邀请玻尔访华。杨振宁曾会见玻尔。但自1952年开始,在苏联的影响下,在中共的领导下,中国学术界开始了对玻尔哲学观点的批判,到文革后期,苏联学者从批判玻尔转变为赞扬玻尔,中国两个刊物仍坚持批判玻尔。直到改革开放,情况才有所改变。1962年玻尔逝世,中国科学界向玻尔家属发去了唁电。自1962年起到1995年,中国有近40名学者访问了玻尔研究所,玻尔的儿子奥格.玻尔曾两次访问中国。1985年玻尔诞辰100周年,中国物理学界进行了隆重的纪念,对玻尔作了很高的评价。戈革为介绍玻尔和翻译玻尔全集奋斗了一生。21世纪以来,中国学术界已没有人对玻尔进行哲学批判,但对玻尔、对哥本哈根学派、对互补观点的评价仍是争论的话题。

  5. Dicty_cDB: SFA691 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 510164 |AJ510164.1 Cloning vector pDXA-3strep. 194 7e-47 2 X85119 |X85119.1 Artificial... sequences cloning vector DNA pDXA-3H. 194 7e-47 2 X85122 |X85122.1 Artificial sequences cloning vector... DNA pDXA-HY. 194 7e-47 2 AJ510165 |AJ510165.1 Cloning vector pDXA-3FLAG. 194 7e-47 2 X85118 |X85118.1 Artificial... sequences cloning vector DNA pDXA-3C. 194 7e-47 2 X85123 |X85123.1 Artificial... sequence. 194 7e-47 2 X85120 |X85120.1 Artificial sequences cloning vector DNA pDXD-3H. 194 8e-47 2 AJ51016

  6. Alpha-decay studies of the new isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At

    CERN Document Server

    Kettunen, H; Grahn, T; Greenlees, P T; Jones, P; Julin, R; Juutinen, S; Keenan, A; Kuusiniemi, P; Leino, M; Leppaenen, A P; Nieminen, P; Pakarinen, J; Rahkila, P; Uusitalo, J


    Detailed alpha-decay studies have been performed for the neutron-deficient isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At. The nuclei were produced in fusion-evaporation reactions of sup 5 sup 4 Fe and sup 5 sup 6 Fe ions with a sup 1 sup 4 sup 1 Pr target. The fusion products were separated in-flight using a gas-filled recoil separator and implanted into a position-sensitive silicon detector. The isotopes were identified using position, time and energy correlations between the implants and subsequent alpha-decays. Three alpha-decaying states were identified for sup 1 sup 9 sup 3 At and two for sup 1 sup 9 sup 1 At. The spin and parity of the initial states in the astatine isotopes were deduced based on unhindered alpha-decays to states in the bismuth daughter nuclei. In both astatine isotopes the 1/2 sup + intruder state was determined to be the ground state and a 7/2 sup - state to be the first-excited state. In sup 1 sup 9 sup 3 At the alpha-decay of the 13/2 sup + state was observed in coincidence...

  7. Periodic Inspections of Cleveland Harbor East Breakwater, Ohio, and Burns Harbor North Breakwater, Indiana (United States)


    81 39.707 929 1 236+50 15 41 32.230 81 39.711 930 1 236+50 20 41 32.230 81 39.711 931 1 236+50 20 41 32.231 81...232+85 20 41 32.194 81 39.775 1010 1 232+85 15 41 32.194 81 39.775 1011 1012 1 232+80 20 41 32.194 81

  8. The Watts New? Collection: Columns by the SEI’s Watts Humphrey (United States)


    194 In Closing, an Invitation to Readers 194 Reference 194 38 Being Your Own Boss—Part V: Building Trust 195 Starting a Job 195 Overcoming Fear 195...a race of procrastinators , and when we can’t avoid or put off some difficult or unpleasant task, we try to replace it with an easier task or get...groups must know how to overcome bureaucratic resistance. This task is not trivial because, once these bureaucratic groups get power, they tend to use

  9. 77 FR 57114 - National Register of Historic Places; Notification of Pending Nominations and Related Actions (United States)


    ..., 12000843 Douglas County French, Charles & Elizabeth Haskell, House, 1300 Haskell Ave., Lawrence, 12000844... CAROLINA Hampton County Lawtonville Baptist Church, 194 E. 4th St., Estill, 12000848 Palmetto Theatre,...

  10. Dicty_cDB: Contig-U00979-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tttttttaatgaacnaa 134 Query: 135 naaattcnagtaaaatcnaaagagnttatgatattaccnatgntntaagnccnttaggtc 194 ||||||||||...|||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 135 naaattcnagtaaaatcnaaagagnttatgatattaccnatgntnt...) Strand = Plus / Minus Query: 125 aatgaacnaanaaattcnagtaaaatcnaaagagnttatgatattaccna...agtaaaatcnaaagagnttatgatattaccnatgntntaagn 25 Query: 185 ccnttaggtctaatccgnaaaac 207 |||||||||||||||||||||||

  11. Difference in moments of inertia and paring interaction strength in superdeformed nuclei

    Institute of Scientific and Technical Information of China (English)

    雷奕安; 林纯镇; 曾谨言


    The difference in the bandhead moments of inertia between the superdeformed (SD) band 194Hg(1) and the two-quasiparticle SD bands 194Hg(2,3) was investigated using the particle-number-conserving treatment for the cranked shell model Hamiltonian, and the pairing interaction strength in SD nuclei is estimated to be much weaker than that in normally deformed nuclei.

  12. Dicty_cDB: Contig-U10506-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 06-1Q) /CSM_Contig/Contig-U10506-1Q.Seq.d NNNNNNNNNNATNTCCAAANAAAATCCNANAACCATATTTNTTAATATTN CCAAAATCGGANATCATCNT...TNCCAATTTNGANAAAACCNTTGGNAAAAC TTGGNTTATTGATTTTGAAAAANAAACAACTAAAATCCNANATGGNAGNT TCNT...TNCNAATATTNAAAANACNTTNATTCNTTGGAANAGACANACNACN ATTGTTGNAAATAATAATAATAATAATGNAATATCCCNTCNTTATTTNAA ...= 9e-54 Identities = 194/194 (100%) Strand = Plus / Plus Query: 14 tccaaanaaaatccnanaaccatatttnttaatattnccaaaatcgganatcatcnt...nanaaccatatttnttaatattnccaaaatcgganatcatcnttnc 73 Query: 74 caatttnganaaaaccnttgg


    NARCIS (Netherlands)



    The alpha-decay of mass separated Bi-190,192,194,196 isotopes has been studied with the LISOL on-line separator. Time sequential alpha-singles spectra were taken and for Bi-190,192,194, alpha-Xt and alpha-gamma-t coincidences were collected. Transition probabilities of levels in Tl-186,188,190 were

  14. EST Table: DC531566 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DC531566 E_ET_J150_21C02_F_0 10/09/28 42 %/194 aa ref|XP_970577.1| PREDICTED: similar to ganglios...006132 10/09/10 n.h 10/09/10 42 %/194 aa gi|91078536|ref|XP_970577.1| PREDICTED: similar to ganglioside-indu

  15. Pamjat teksta i tekst kak pamjat / Ülle Pärli

    Index Scriptorium Estoniae

    Pärli, Ülle


    Bibl. lk. 194. Kokkuvõtted eesti k. "Teksti mälu ja tekst kui mälu" ning inglise k. "The memory of a text and text as a memory", lk. 194-195. Jossif Brodski luuletusest "Järelsõna valmile" ("Posleslovije k basne")

  16. Is electronegativity a useful descriptor for the pseudo-alkali metal NH4? (United States)

    Whiteside, Alexander; Xantheas, Sotiris S; Gutowski, Maciej


    Molecular ions in the form of "pseudo-atoms" are common structural motifs in chemistry, with properties that are transferrable between different compounds. We have determined one such property--the electronegativity--for the "pseudo-alkali metal" ammonium (NH(4)), and evaluated its reliability as a descriptor versus the electronegativities of the alkali metals. The computed properties of ammonium's binary complexes with astatine and of selected borohydrides confirm the similarity of NH(4) to the alkali metal atoms, although the electronegativity of NH(4) is relatively large in comparison to its cationic radius. We have paid particular attention to the molecular properties of ammonium (angular anisotropy, geometric relaxation and reactivity), which can cause deviations from the behaviour expected of a conceptual "true alkali metal" with this electronegativity. These deviations allow for the discrimination of effects associated with the molecular nature of NH(4).

  17. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V


    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  18. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others


    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  19. Specific binding of Clostridium perfringens enterotoxin fragment to Claudin-b and modulation of zebrafish epidermal barrier. (United States)

    Zhang, Jingjing; Ni, Chen; Yang, Zhenguo; Piontek, Anna; Chen, Huapu; Wang, Sijie; Fan, Yiming; Qin, Zhihai; Piontek, Joerg


    Claudins (Cldn) are the major components of tight junctions (TJs) sealing the paracellular cleft in tissue barriers of various organs. Zebrafish Cldnb, the homolog of mammalian Cldn4, is expressed at epithelial cell-cell contacts and is important for regulating epidermal permeability. The bacterial toxin Clostridium perfringens enterotoxin (CPE) has been shown to bind to a subset of mammalian Cldns. In this study, we used the Cldn-binding C-terminal domain of CPE (194-319 amino acids, cCPE 194-319 ) to investigate its functional role in modulating zebrafish larval epidermal barriers. In vitro analyses show that cCPE 194-319 removed Cldn4 from epithelial cells and disrupted the monolayer tightness, which could be rescued by the removal of cCPE 194-319. Incubation of zebrafish larvae with cCPE 194-319 removed Cldnb specifically from the epidermal cell membrane. Dye diffusion analysis with 4-kDa fluorescent dextran indicated that the permeability of the epidermal barrier increased due to cCPE 194-319 incubation. Electron microscopic investigation revealed reversible loss of TJ integrity by Cldnb removal. Collectively, these results suggest that cCPE 194-319 could be used as a Cldnb modulator to transiently open the epidermal barrier in zebrafish. In addition, zebrafish might be used as an in vivo system to investigate the capability of cCPE to enhance drug delivery across tissue barriers.

  20. Clinical outcome following a low-suspicion multiparametric prostate MRI or benign MRI-guided biopsy to detect prostate cancer

    DEFF Research Database (Denmark)

    Boesen, Lars; Nørgaard, Nis; Løgager, Vibeke;


    predictive values of MRI in ruling out any prostate cancer and significant prostate cancer defined as: a) any core with Gleason score (GS) > 6 or b) > 2 positive cores/cancerous core ≥ 50%. RESULTS: Prostate cancer was detected in 38/194 (20%) patients during the median study period of 47 months...... (interquartile range 43-52). The overall negative predictive value of MRI in ruling out any and significant prostate cancer was 80% (156/194) and 95% (184/194), respectively. No patient with a low-suspicion MRI had intermediate/high grade cancer (Gleason score > 6). The majority of patients with no cancer during...

  1. EST Table: FY010502 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY010502 bmov30g16 11/11/04 100 %/194 aa dbj|BAB16697.1| annexin [Bombyx mori] dbj|BAB16698.1| anne....9a#CE23956#WBGene00003589#locus:nex- 2#Annexin#status:Confirmed#UniProt:Q27512#protein_id:CAA 82571.2 11/11...62 %/194 aa gnl|Amel|GB16448-PA 11/11/04 72 %/194 aa gi|91092420|ref|XP_967931.1| PREDICTED: similar to Annexin IX CG5730-PC [Tribolium castaneum] NM_001043376 bmov ...

  2. Modeling geochemical datasets for source apportionment: Comparison of least square regression and inversion approaches.

    Digital Repository Service at National Institute of Oceanography (India)

    Tripathy, G.R.; Das, Anirban.

    . Analysis of different modes of factor analysis as least squares fit problems. Chemometrics and Intelligent Laboratory Systems 18, 183–194. Paatero, P., 1997. Least squares formulation of robust non-negative factor analysis. Chemometrics and Intelligent...

  3. The Effects on Students’ Conceptual Understanding of Electric Circuits of Introducing Virtual Manipulatives Within a Physical Manipulatives-Oriented Curriculum

    NARCIS (Netherlands)

    Zacharia, Zacharias C.; Jong, de Ton


    This study investigates whether Virtual Manipulatives (VM) within a Physical Manipulatives (PM)-oriented curriculum affect conceptual understanding of electric circuits and related experimentation processes. A pre–post comparison study randomly assigned 194 undergraduates in an introductory physics

  4. FAA Air Traffic Activity: Fiscal Year 1988 (United States)


    186160481 132857 1396 SANTA MARIA PUBLIC (SMX) N ITINERANT OPERATIONS...195815 61580 101949 27321 4965 SAN JUAN ISLA GRANDE (SIG) L ITINERANT OPERATIONS...194 132740 SANTA MARIA PUBLIC ...................................... CA N 274 88663 OSHKOSH WITTMAN FIELD ............................ WI N 195 132453

  5. Questions and Answers: Runny Nose (with Green or Yellow Mucus) (United States)

    ... Get Smart: Know When Antibiotics Work on the Farm Get Smart About Antibiotics Week One Page Sheet: Runny Nose ... Get Smart: Know When Antibiotics Work on the Farm Get Smart About Antibiotics Week Format: Select one PDF [194 ...

  6. Effect of Family Structure on Marital Attitudes of Adolescents. (United States)

    Ganong, Lawrence; And Others


    Assesses the effect of exposure to different family structures (single parent families, reconstituted families, intact families) on the marital socialization of 127 males and 194 female adolescents. (Author/CM)

  7. Fire Management Plan: Upper Mississippi River National Wildlife and Fish Refuge (United States)

    US Fish and Wildlife Service, Department of the Interior — The Upper Mississippi River National Wildlife and Fish Refuge consists of approximately 194,000 acres of wooded islands, waters and marshes extending southward along...

  8. Eimuntas Nekroshiuse teatripoeetika / Ruta Mazheikiene ; tõlk. Tiina Kattel

    Index Scriptorium Estoniae

    Mazheikiene, Ruta


    E. Nekroshiuse lavastustele iseloomulikest joontest, toetudes tema lavastustele "Hamlet" "Macbeth", "Othello", "Onu Vanja", "Nina". Samuti näitlejatega töötamise strateegiast. Kasut. kirjandus, lk. 194-195

  9. Distribution and air–sea exchange of nitrous oxide in the coastal Bay of Bengal during peak discharge period (southwest monsoon)

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, G.D.; Rao, V.D.; Sarma, V.V.S.S.

    chlorophyll using N, N-dimethylformamide. J Oceanography. 1990; 46: 190-194. Suntharalingam P, Sarmiento JL. Factors governing the oceanic nitrous oxide distribution; simulation with an ocean general circulation model. Global Biogeochem cycles. 2000; 14...

  10. Effect of aging and obesity on the expression of dyslipidemia in children from families with familial combined hyperlipidaemia


    ter Avest, Ewoud; Sniderman, Allan D.; Bredie, Sebastian JH; Wiegman, Albert; Stalenhoef, Anton FH; de Graaf, Jacqueline


    Abstract Objective: To delineate the mechanism(s) responsible for the increased secretion of very low density lipoprotein particles (VLDL) in patients with familial combined hyperlipidemia (FCH). Methods: In 194 young adults (

  11. Dicty_cDB: Contig-U13692-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available D504Z ,194,812 Translated Amino Acid sequence mv*lqsiwvvvvwigy*livtf*lnkiqywlgiwqsq*hvacfiymignqiqyfieiyqq r...fvf*nsckylskk Frame C: mv*lqsiwvvvvwigy*livtf*lnkiqywlgiwqsq*hvacfiymignqiqyfieiy

  12. Dicty_cDB: Contig-U14577-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 1 gtggtntncaaccactgtgctcacatanttactactgtgtggttcagactanctgcgtcc 70 ||||||||||||||||||||||||||||||||||||||||||...|||||||||||||||||| Sbjct: 11 gtggtntncaaccactgtgctcacatanttactactgtgtggttcagactan...(204), Expect = e-109 Identities = 252/252 (100%) Strand = Plus / Minus Query: 12 tggtntncaaccactgtgctcacatan...3 tggtntncaaccactgtgctcacatanttactactgtgtggttcagactanctgcgtccc 194 Query: 72 nanc...ttactactgtgtggttcagactanctgcgtccc 71 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 25

  13. Innovaatiline mõtlemine nõuab juhilt julgust kastist välja tulla / Alexander Kotchubei

    Index Scriptorium Estoniae

    Kotchubei, Alexander, 1963-


    Ilmunud ka: Juhi ideelaegas. - Tallinn, 2006, lk. 194-196. Uuenduslikkuse aluseks on konkurentidest efektiivsem mõtlemine. Vt. samas: Tänapäeva juht peab olema avatud ja riskijulge; Uusi ideid soodustavad muudatused mõtteviisis

  14. First indication of population of superdeformed states by incomplete fusion reactions

    Energy Technology Data Exchange (ETDEWEB)

    Kaci, M.; Azaiez, F.; Bouneau, S.; Duprat, J.; Bourgeois, C.; Sergolle, H. [IPN, IN2P3-CNRS, Bat 104-108, F-91406 Orsay (France); Gueorguieva, E.; Porquet, M.G.; Deloncle, I.; Dozie, N. [CSNSM, IN2P3-CNRS, Bat 104, F-91405 Orsay (France); Aleonard, M.M. [CENBG, IN2P3-CNRS, F-33170 Gradignan (France); Astier, A.; Ducroux, L.; Meyer, M.; Redon, N. [IPN, IN2P3-CNRS Villeurbanne (France); Baldsiefen, G.; Korten, W.; van Severen, U.J. [ISKP, University of Bonn, Nussallee 14-16, D-53115 Bonn (Germany); Beausang, C.W. [Oliver Lodge Laboratory, University of Liverpool, P.O. Box 147, Liverpool L69 3BX (United Kingdom); Beck, F.A.; Curien, D.; Gall, B.J.; Prevost, D. [CRN, IN2P3-CNRS, F-67037 Strasbourg (France); Sharpey-Schafer, J.F. [NAC, Faure P.O. Box 72, ZA 7131 Cape Town (South Africa)


    The high-spin normally deformed and superdeformed states of {sup 194}Hg have been populated in an exit channel of the {sup 16}O+{sup 186}W reaction at 110 MeV bombarding energy. The Doppler shift analysis of the energies of the {gamma} transitions de-exciting both normally deformed and superdeformed states in {sup 194}Hg indicates a lower recoil velocity of the {sup 194}Hg nucleus compared to that of the {sup 196}Pb nucleus obtained from the 6n exit channel of the complete-fusion compound nucleus. This suggests that incomplete fusion plays the main role in the population of normally deformed and superdeformed states of {sup 194}Hg in this reaction. {copyright} {ital 1997} {ital The American Physical Society}

  15. Drug: D06649 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available atment of patients undergoing percutaneous coronary interventions Monoclonal antibody glycoprotein alphaIIb/...ADYEKHK VYACEVTHQG LSSPVTKSFN RGEC (Disulfide bridge: 23-88; 134-194) Peptide Tre

  16. Fish and Wildlife Habitat Changes Resulting from Construction of a Nine-Foot Channel on Pools 24, 25, and 26 of the Mississippi River and the Lower Illinois River, (United States)


    Sphaeriidae (fingernail clams) 10.4 52 35.4 19.4 Corbiculidae (Asiatic clams) 2.6 19.4 Unionidae (mussels) 1.0 1.1 Insecta (insects) Odonata ...fingernail clams) 2.4 3.5 Corbiculidae (Asiatic clams) 9.8 Unionidae (mussels) 0.1 Insecta (insects) Odonata (dragonflies) 0.1 Ephemeroptera...Trichoptera claws Polecypoda. Dobson flies Neuroptera Dragonflies Odonata Fingernail clan MgcjjJu. taneverui - Svhacriu transversu Fingernail clams

  17. Population Density Modeling Tool (United States)


    194 POPULATION DENSITY MODELING TOOL by Davy Andrew Michael Knott David Burke 26 June 2012 Distribution...MARYLAND NAWCADPAX/TR-2012/194 26 June 2012 POPULATION DENSITY MODELING TOOL by Davy Andrew Michael Knott David Burke...Density Modeling Tool 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Davy Andrew Michael Knott David Burke 5d. PROJECT NUMBER

  18. Dicty_cDB: Contig-U16173-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available japonicum isolate Anhu... 200 3e-49 AB367929_1( AB367929 |pid:none) Theileria sergenti CCTeta gene for... 19...ana AT5g20890/F22... 199 4e-49 AB367931_1( AB367931 |pid:none) Theileria sergenti CCTeta mRNA for... 199 4e-.... 194 2e-47 AB367930_1( AB367930 |pid:none) Theileria sergenti CCTeta gene for... 194 2e-47 BC065324_1( BC06

  19. Hospital Security and Force Protection: A Guide to Ensuring Patient and Employee Safety (United States)


    removed from the mother baby unit. This technology also may be attached to equipment, decreasing theft of wheelchairs and other easily lost items (Noble... Pediatric Emergency Care, 19(4), 248-251. Hospital Security 93 State of Delaware. (2005). The history of terrorism: More than 200 years of development... Pediatric Emergency Care, 19(4), 248-251. Sullivan, M., & Donnelly, B. (2005). Emergency department response to terrorism. Topics in Emergency Medicine, 27

  20. WORLD PORT INDEX Nineteenth Edition (United States)


    H E LT E R T ID E S W E LL IC E O T H E R C H A N N E L T ID E 172 54585 SALADIN MARINE TERMINAL AS 2124S 11503E 175 74517 V OR P Y Y Y J J J 01...SAKAIMINATO JA 159 61760 SAKATA-KO JA 159 61900 SAKHALIN 60840 SAKSKOBING DA 194 29660 SALACGRIVA LG 194 28605 SALADIN MARINE TERMINAL AS 175 54585

  1. New supersymmetric quartet of nuclei in the A=190 mass region

    CERN Document Server

    Barea, J; Frank, A; Graw, G; Hertenberger, R; Wirth, H F; Christen, S; Jolie, J; Tonev, D; Balodis, M; Berzins, J; Kramere, N; Von Egidy, T


    We present evidence for a new supersymmetric quartet in the A=190 region of the nuclear mass table. New experimental information on transfer and neutron capture reactions to the odd-odd nucleaus 194 Ir strongly suggests the existence of a new supersymmetric quartet, consisting of the 192,193 Os and 193,194 Ir nuclei. We make explicit predictions for the odd-neutron nucleus 193 Os, and suggest that its spectroscopic properties be measured in dedicated experiments.

  2. A new species of elongate unpatterned moray eel of the genus Gymnothorax (Muraenidae: Muraeninae) from the Bay of Bengal. (United States)

    Mohapatra, Anil; Ray, Dipanjan; Smith, David G; Mishra, Subhrendu Sekhar


    An elongate, brown unpatterned moray eel, Gymnothorax indicus sp. nov., is described based on four specimens collected from the northern Bay of Bengal. The new species is differentiated from other elongate, unpatterned moray eels in having the following combination of characters: anus at about mid-point of body, preanal length 2.0 in total length; snout blunt and short; dorsal fin margin black, 5 mandibular pores; maxillary teeth uniserial, sharp and depressible, total vertebrae 194 (MVF: 9-79-194).

  3. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk

    Energy Technology Data Exchange (ETDEWEB)

    Mohrenweiser, H W; Han, J; Hankinson, S E; De Vivo, I; Spiegelman, D; Tamimi, R M; Colditz, G A; Hunter, D J


    The XRCC1 protein is involved in the base excision repair pathway through interactions with other proteins. Polymorphisms in the XRCC1 gene may lead to variation in repair proficiency and confer inherited predisposition to cancer. We prospectively assessed the associations between polymorphisms and haplotypes in XRCC1 and breast cancer risk in a nested case-control study within the Nurses' Health Study (incident cases, n 1004; controls, n 1385). We further investigated gene-environment interactions between the XRCC1 variations and plasma carotenoids on breast cancer risk. We genotyped four haplotype-tagging single nucleotide polymorphisms Arg {sup 194}Trp, C26602T, Arg{sup 399}Gln, and Gln{sup 632}Gln in the XRCC1 gene. Five common haplotypes accounted for 99% of the chromosomes in the present study population of mostly Caucasian women. We observed a marginally significant reduction in the risk of breast cancer among {sup 194}Trp carriers. As compared with no-carriers, women with at least one {sup 194}Trp allele had a multivariate odds ratio of 0.79 (95% of the confidence interval, 0.60 -1.04). The inferred haplotype harboring the {sup 194}Trp allele was more common in controls than in cases (6.6 versus 5.3%, P 0.07). We observed that the Arg {sup 194}Trp modified the inverse associations of plasma -carotene level (P, ordinal test for interaction 0.02) and plasma -carotene level (P, ordinal test for interaction 0.003) with breast cancer risk. No suggestion of an interaction was observed between the Arg {sup 194}Trp and cigarette smoking. Our results suggest an inverse association between XRCC1 {sup 194}Trp allele and breast cancer risk. The findings of the effect modification of the Arg {sup 194}Trp on the relations of plasma -and -carotene levels with breast cancer risk suggest a potential protective effect of carotenoids in breast carcinogenesis by preventing oxidative DNA damage.

  4. Commanding Generation Y: How Generation X Military Leaders Can Better Utilize Generational Tendencies (United States)


    collaborative, polite to authority, comfortable with multitasking, and seeks continual feedback from superiors. Commanding Generation Y is...14 Mike Atkinson, “Advice for (and from) the youngest at heart: Understanding the millennial generation ,” Guidance and Counseling, 19(4), 153-157...Atkinson, M.L. “Advice for (and from) the youngest at heart: Understanding the millennial generation .” Guidance and Counseling, 19(4), 153-157

  5. GETDB: 113539 [GETDB

    Lifescience Database Archive (English)

    Full Text Available Genetics. FM7c Link to clone table - 2 194 Link to cluster table 194 1 Request - uniform in epidermis (from to st.15) ubiquitous in 3rd larva. strong in disc. no pattern. sh. uniform i...uest - Embryonic Expression uniform in epidermis (from st.9 to st.15) Larval GFP ...ubiquitous in 3rd larva. strong in disc. no pattern. Larval X-gal sh. uniform in wing disc. Adult GFP - Leth

  6. An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV.

    Directory of Open Access Journals (Sweden)

    Jennifer D Watkins

    Full Text Available Neutralizing antibodies have been shown to protect macaques against SHIV challenge. However, genetically diverse HIV-1 clades have evolved, and a key question left unanswered is whether neutralizing antibodies can confer cross-clade protection in vivo. The novel human monoclonal antibody HGN194 was isolated from an individual infected with an HIV-1 clade AG recombinant circulating recombinant form (CRF. HGN194 targets an epitope in the third hypervariable loop (V3 of HIV-1 gp120 and neutralizes a range of relatively neutralization-sensitive and resistant viruses. We evaluated the potential of HGN194 to protect infant rhesus monkeys against a SHIV encoding a primary CCR5-tropic HIV-1 clade C envelope. After high-dose mucosal challenge, all untreated controls became highly viremic while all HGN194-treated animals (50 mg/kg were completely protected. When HGN194 was given at 1 mg/kg, one out of two monkeys remained aviremic, whereas the other had delayed, lower peak viremia. Interestingly, all protected monkeys given high-dose HGN194 developed Gag-specific proliferative responses of both CD4+ and CD8+ T cells. To test whether generation of the latter involved cryptic infection, we ablated CD8+ cells after HGN194 clearance. No viremia was detected in any protected monkeys, thus ruling out virus reservoirs. Thus, induction of CD8 T-cell immunity may have resulted from transient "Hit and Run" infection or cross priming via Ag-Ab-mediated cross-presentation. Together, our data identified the HGN194 epitope as protective and provide proof-of-concept that this anti-V3 loop mAb can prevent infection with sterilizing immunity after challenge with virus of a different clade, implying that V3 is a potential vaccine target.

  7. Droplet Combustion and Non-Reactive Shear-Coaxial Jets with Transverse Acoustic Excitation (United States)


    Ao/Ai, large t/D1 injector showed strong response at the forcing frequency. iv The dissertation of Sophonias Teshome is approved. Russel E. Caflisch...Professor Xiaolin Zhong and Professor Russel Caflisch are very much appreciated. I would like to recognize current and former lab colleagues including...Reardon. Liquid propellant rocket combustion instability. nasa sp-194. NASA Special Publication, 194, 1972. [26] K.C. Schadow, E. Gutmark, T.P. Parr

  8. [Improving maltodextrin specificity by site-saturation engineering of subsite +1 in cyclodextrin glycosyltransferase from Paenibacillus macerans]. (United States)

    Xu, Qiaoyan; Han, Ruizhi; Li, Jianghua; Du, Guocheng; Liu, Long; Chen, Jian


    By engineering the subsite +1 of cyclodextrin glycosyltransferase (CGTase) from Paenibacillus macerans, we improved its maltodextrin specificity for 2-O-D-glucopyranosyl-L-ascorbic acid (AA-2G) synthesis. Specifically, we conducted site-saturation mutagenesis on Leu194, Ala230, and His233 in subsite +1 separately and gained 3 mutants L194N (leucine --> asparagine), A230D (alanine --> aspartic acid), and H233E (histidine --> glutamic acid) produced higher AA-2G yield than the wild-type and the other mutant CGTases. Therefore, the 3 mutants L194N, A230D, and H233E were further used to construct the double and triple mutations. Among the 7 obtained combinational mutants, the triple mutant L194N/A230D/H233E produced the highest AA-2G titer of 1.95 g/L, which was increased by 62.5% compared with that produced by the wild-type CGTase. Then, we modeled the reaction kinetics of all the mutants and found a substrate inhibition by high titer of L-AA for the mutants. The optimal temperature, pH, and reaction time of all the mutants were also determined. The structure modeling indicated that the enhanced maltodextrin specificity may be related with the changes of hydrogen bonding interactions between the side chain of residue at the three positions (194, 230 and 233) and the substrate sugars.

  9. Rhodobacter megalophilus sp. nov., a phototroph from the Indian Himalayas possessing a wide temperature range for growth. (United States)

    Arunasri, K; Venkata Ramana, V; Spröer, C; Sasikala, Ch; Ramana, Ch V


    Two strains of phototrophic, purple non-sulfur bacteria capable of growing at low temperatures (5 degrees C) were isolated from the Himalayas. The two strains showed positive phototaxis and grew over a relatively wide temperature range (5-40 degrees C). Phylogenetic analysis based on 16S rRNA gene sequences showed that strain JA194T clustered with members of the genus Rhodobacter. Strain JA194T showed highest 16S rRNA gene sequence similarity with Rhodobacter sphaeroides DSM 158T (99 %). However, DNA-DNA hybridization experiments between Rba. sphaeroides DSM 158T and strain JA194T revealed a level of relatedness of only 67 %. The DNA base composition of strain JA194T was 66.67 mol% G+C (by HPLC). Based on 16S rRNA gene sequence analysis, morphological, physiological, Fourier transform infrared fingerprinting and DNA-DNA hybridization studies, strain JA194T (=KCTC 5602T =JCM 14598T) is sufficiently different from other Rhodobacter species to merit its description as the type strain of a novel species, for which the name Rhodobacter megalophilus sp. nov. is proposed.

  10. Inhibition of Metastatic Potential in Breast Carcinoma In Vivo and In Vitro through Targeting VEGFRs and FGFRs

    Directory of Open Access Journals (Sweden)

    Ming-Hsien Chien


    Full Text Available Angiogenesis and lymphangiogenesis are considered to play key roles in tumor metastasis. Targeting receptor tyrosine kinases essentially involved in the angiogenesis and lymphangiogenesis would theoretically prevent cancer metastasis. However, the optimal multikinase inhibitor for metastasis suppression has yet to be developed. In this study, we evaluated the effect of NSTPBP 0100194-A (194-A, a multikinase inhibitor of vascular endothelial growth factor receptors (VEGFRs/fibroblast growth factor receptors (FGFRs, on lymphangiogenesis and angiogenesis in a mammary fat pad xenograft model of the highly invasive breast cancer cell line 4T1-Luc+. We investigated the biologic effect of 194-A on various invasive breast cancer cell lines as well as endothelial and lymphatic endothelial cells. Intriguingly, we found that 194-A drastically reduced the formation of lung, liver, and lymph node metastasis of 4T1-Luc+ and decreased primary tumor growth. This was associated with significant reductions in intratumoral lymphatic vessel length (LVL and microvessel density (MVD. 194-A blocked VEGFRs mediated signaling on both endothelial and lymphatic endothelial cells. Moreover, 194-A significantly inhibited the invasive capacity induced by VEGF-C or FGF-2 in vitro in both 4T1 and MDA-MB231 cells. In conclusion, these experimental results demonstrate that simultaneous inhibition of VEGFRs/FGFRs kinases may be a promising strategy to prevent breast cancer metastasis.

  11. Identification of Specific Effect of Chloride on the Spectral Properties and Structural Stability of Multiple Extracellular Glutamic Acid Mutants of Bacteriorhodopsin (United States)

    Lazarova, Tzvetana; Mlynarczyk, Krzysztof; Querol, Enric; Tenchov, Boris; Filipek, Slawomir; Padrós, Esteve


    In the present work we combine spectroscopic, DSC and computational approaches to examine the multiple extracellular Glu mutants E204Q/E194Q, E204Q/E194Q/E9Q and E204Q/E194Q/E9Q/E74Q of bacteriorhodopsin by varying solvent ionic strength and composition. Absorption spectroscopy data reveal that the absorption maxima of multiple EC Glu mutants can be tuned by the chloride concentration in the solution. Visible Circular dichroism spectra imply that the specific binding of Cl- can modulate weakened exciton chromophore coupling and reestablish wild type-like bilobe spectral features of the mutants. The DSC data display reappearance of the reversible thermal transition, higher Tm of denaturation and an increase in the enthalpy of unfolding of the mutants in 1 M KCl solutions. Molecular dynamics simulations indicate high affinity binding of Cl- to Arg82 and to Gln204 and Gln194 residues in the mutants. Analysis of the experimental data suggests that simultaneous elimination of the negatively charged side chain of Glu194 and Glu204 is the major cause for mutants’ alterations. Specific Cl- binding efficiently coordinates distorted hydrogen bonding interactions of the EC region and reconstitutes the conformation and structure stability of mutated bR in WT-like fashion. PMID:27657718

  12. Development of Reagents for Application of At-211 to Targeted Radionuclide Therapy of Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott


    This grant covered only a period of 4 months as the major portion of the award was returned to DOE due to an award of funding from NIH that covered the same research objectives. A letter regarding the termination of the research is attached as the last page of the Final Report. The research conducted was limited due to the short period of this grant, but the results obtained in that period are outlined in the Final Report. The studies addressed in the research effort were directed at a problem that is of critical importance to the in vivo application of the alpha-particle emitting radionuclide At-211. That problem, low in vivo stability of many astatinated molecules, severely limits the use of At-211 in therapeutic applications. The advances sought in the studies were expected to expand the types of biomolecules that can be used as carriers of At-211, and provide improved in vivo targeting of the radiation dose compared with the dose delivered to normal tissue.

  13. Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with {sup 211}At-EGF

    Energy Technology Data Exchange (ETDEWEB)

    Sundberg, Aasa Liljegren; Orlova, Anna; Gedda, Lars; Tolmachev, Vladimir; Carlsson, Joergen [Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala (Sweden); Almqvist, Ylva [Division of Radiology, Uppsala University, Uppsala (Sweden); Blomquist, Erik [Division of Oncology, Uppsala University, Uppsala (Sweden); Jensen, Holger J. [Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Rigshospitalet, Copenhagen (Denmark)


    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib ['Iressa' (trademark of the AstraZeneca group of companies), ZD1839] increases the cellular uptake of radiolabelled epidermal growth factor (EGF). We investigated gefitinib treatment combined with astatine-211 EGF targeting in vitro using two cell lines expressing high levels of EGFR: A431 (sensitive to gefitinib) and U343MGaCl2:1 (resistant to gefitinib). In both cell lines, the uptake of {sup 211}At-EGF was markedly increased by concomitant treatment with gefitinib. Survival was investigated using both a clonogenic survival assay and a cell growth assay. Combined gefitinib and {sup 211}At-EGF treatment reduced the survival of U343 cells 3.5-fold compared with {sup 211}At-EGF alone. In A431 cells, {sup 211}At-EGF treatment resulted in very low survival, but combined treatment with gefitinib increased the survival by about 20-fold. These results indicate that combined treatment with gefitinib might increase the effect of ligand-mediated radionuclide therapy in gefitinib-resistant tumours and decrease the effect of such therapy in gefitinib-sensitive tumours. (orig.)

  14. Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Nestor, Marika, E-mail: marika.nestor@bms.uu.s [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden); Sundstroem, Magnus [Unit of Molecular Pathology, Department of Genetics and Pathology, Uppsala University (Sweden); Anniko, Matti [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Tolmachev, Vladimir [Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden)


    Aim: The monoclonal antibody cetuximab, targeting the epidermal growth factor receptor (EGFR), is a promising molecular targeting agent to be used in combination with radiation for anticancer therapy. In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed. Methods: SCC cell lines were characterized and treated with cetuximab in combination with anti-CD44v6 RIT using the astatinated chimeric monoclonal antibody U36 ({sup 211}At-cMAb U36). Effects on {sup 211}At-cMAb U36 uptake, internalization and cell proliferation were then assessed in SCC cells. Results: Cetuximab in combination with {sup 211}At-cMAb U36 mediated increased growth inhibition compared to RIT or cetuximab alone in two cell lines. However, cetuximab also mediated radioprotective effects compared to RIT alone in two cell lines. The radioprotective effects occurred in the cell lines in which cetuximab clearly inhibited cell growth during radiation exposure. Cetuximab treatment also influenced {sup 211}At-cMAb-U36 uptake and internalization, suggesting interactions between CD44v6 and EGFR. Conclusions: Results from this study demonstrate the vast importance of further clarifying the mechanisms of cetuximab and radiation response, and the relationship between EGFR and suitable RIT targets. This is important not only in order to avoid potential radioprotective effects, but also in order to find and utilize potential synergistic effects from these combinations.

  15. Cyclotron production of cesium radionuclides as analogues for francium-221 biodistribution (United States)

    Finn, R.; McDevitt, M.; Sheh, Y.; Lom, C.; Qiao, J.; Cai, S.; Burnazi, E.; Nacca, A.; Pillarsetty, N.; Jaggi, J.; Scheinberg, D.


    In our clinical investigations focussing on improved therapeutic treatment of specific tumors we have concentrated on a targeted therapy approach utilizing designed radiolabeled monoclonal antibodies as the cytotoxic reagent. The physical characteristics of the alpha particle emitting radionuclide bismuth-213 including the short half-life of 45.6 min, has shown promise for the treatment of specific cancers such as leukemias and lymphomas or micrometastatic carcinomas. In an effort to increase the cytocidal effect of the HuM195, a humanized monoclonal antibody carrier to the CD33 antigen expressed on leukemia cells, our focus is directed toward an "internal" nano-generator composed of Ac-225 radionuclide, the parent of the bismuth-213. The actinium-225 radionuclide decays through several short-lived, alpha emitting daughters including francium-221, astatine-217 and bismuth-213. In order to study the biodistribution and the pharmacokinetics of the individual daughter nuclide, francium-221, the cyclotron production and separation of cesium radionuclides, specifically cesium-132, from a natural xenon gas target was undertaken. The choice of cesium as an analogue for francium was predicated upon both elements being in Group 1A alkali metals and cesium radionuclide possesses a sufficient half-life to allow biodistribution studies to be performed. The preliminary experimental results of this investigation are presented.

  16. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré


    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  17. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  18. Metalloids, soil chemistry and the environment. (United States)

    Lombi, Enzo; Holm, Peter E


    This chapter reviews physical chemical properties, origin and use ofmetalloids and their relevance in the environment. The elements boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), tellurium (Te), polonium (Po) and astatine (At) are considered metalloids. Metalloids conduct heat and electricity intermediate between nonmetals and metals and they generally form oxides. The natural abundance ofmetalloids varies from Si being the second most common element in the Earth's crust to At as the rarest of natural elements on Earth. The metalloid elements Ge, Te, Po and At are normally present in trace or ultratrace levels in the environment and as such are not considered of relevance in terms of environmental health. The environmental geochemical processes, factors and parameters controlling the partitioning and the speciation of B, Si, As and Sb are reviewed in relation to the bioavailability of these metalloids. Approaches based on the hypothesis that metal toxicity is related to both the metal-ligand complexation processes and the metal interactions with competing cations at the cell surface (biotic ligand) have so far not been successful for assessing metalloid bioavailability. The chapter concludes that our understanding of metalloids toxicity will improve in the future if, in addition to the points discussed above, surface membrane potentials are considered. This should represent a robust approach to the prediction of metalloid toxicity.

  19. SPECT assay of radiolabeled monoclonal antibodies. Progress report, September 1, 1992--August 24, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.


    The overall goal of this project is to improve the effectiveness of single photon emission computed tomography (SPECT) to image and quantify radiolabeled monoclonal antibodies. During the past year, we have made significant progress toward this goal, and this report summarizes that work. Our efforts have been mainly directed along three fronts. First, we have developed and tested new reconstruction methods including three-dimensional iterative algorithms that model non-uniform attenuation and distance-dependent detector response. Both fan beam and parallel beam collimator geometries have been modeled and novel ways of improving the efficiency of the computationally intensive methods have been introduced. Second, an ultra-high resolution, small field-of-view pinhole collimator has been constructed and evaluated. Reconstructed spatial resolution of 1 to 3 mm (FWHM) has been achieved in phantom scans with a useful field-of-view of 9 to 10 cm. Finally, we have investigated the ability of SPECT to image and quantify astatine-211 distributions. Reconstructed images of phantom data demonstrated quantitative accuracy to within 10% with proper attenuation and scatter compensation.

  20. Glomerular filtration rate after alpha-radioimmunotherapy with 211At-MX35-F(ab')2: a long-term study of renal function in nude mice

    DEFF Research Database (Denmark)

    Back, T.; Haraldsson, B.; Hultborn, R;


    and animals bearing subcutaneous xenografts of the human ovarian cancer cell line, OVCAR-3, were used. The animals received approximately 0.4, 0.8, or 1.2 MBq in one, two, or three fractions. The mean absorbed doses to the kidneys ranged from 1.5 to 15 Gy. The renal function was studied by serial GFR...... of the glomerular filtration rate (GFR). The renal toxicity was evaluated at levels close to the dose limit for the bone marrow and well within the range for therapeutic efficacy on tumors. Astatinated MX35-F(ab')(2) monoclonal antibodies were administered intravenously to nude mice. Both non-tumor-bearing animals...... manifested late. Examination of the kidney sections showed histologic changes that were overall subdued. Following alpha-RIT with (211)At-MX35-F(ab')(2) at levels close to the dose limit of severe myelotoxicity, the effects found on renal function were relatively small, with only minor to moderate reductions...

  1. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics


    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  2. Studies of Stable Octupole Deformations in the Radium Region

    CERN Multimedia


    The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

  3. Alpha particle emitters in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, D.R.


    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ({sup 211}At) and natural bismuth-212 ({sup 212}Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ({sup 223}Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

  4. Genomic and proteomic analysis of soybean heritable variations induced by space flight

    Institute of Scientific and Technical Information of China (English)

    HE Jie; GAO Yong; SUN Ye-qing


    To analyze the biological effects of space environment, the diversity of genomic DNA between the space flight soybean 194(4126) with phenotype of good yield and good fruit quality induced by space flight and the soybean with ground control was studied by amplified fragment length polymorphism (AFLP) method, and the polymorphism of space flight soybean 194(4126) was 3.56%. The differences of protein expression of seeds and leaves between the two kinds of soybeans were analysed by two-dimensional electrophoresis, PDQuest software and MALDI-TOF mass spectrometry. Results show that the loss and decrease of protein expression in 194(4126) soybean are subjected to the space fight of seeds, and three special proteins including Dehydrin, MAT1 and ceQORH are identified. It is concluded that the space environment changes the phenotype and geno-type of soybeans due to the space flight of seeds.

  5. An overview of the recent results on fission dynamics from the NAND facility

    Indian Academy of Sciences (India)

    B R Behera


    This paper summarizes the results of some of the recent fusion–fission experiments carried out at the National Array of Neutron Detectors (NAND) Phase-01 installed at the Pelletron+LINAC accelerator facility of Inter-University Accelerator Centre (IUAC), New Delhi. Pre-scission neutron multiplicity excitation functions are measured for the 213,215,217Fr, 210,212,214,216Rn and 206,210Po compound nuclei populated through the fusion of the 19F+194,196,198Pt, 16,18O+194,198Pt and 12C+194,198Pt systems, respectively. Pre-scission neutron yields from these reactions are compared with the extensive statistical model calculations to look for the effects due to the compound nucleus shell closure, / ratio of the compound nucleus, magnitude of the saddle-point shell corerction and fission time-scale.

  6. Search for new candidates for the neutrino-oriented mass determination by electron-capture

    CERN Multimedia

    Herfurth, F; Boehm, C; Blaum, K; Beck, D


    This proposal is part of an extended program dedicated to the neutrino-mass determination in the electron-capture sector, which aims at ultra-precise mass measurements by Penning traps in combination with cryogenic micro-calorimetry for atomic de-excitation measurements. Here, precise mass measurements with ISOLTRAP are proposed for the orbital electron-capture nuclides $^{194}$Hg and $^{202}$Pb, as well as their daughters, with the goal to determine accurately their Q-values. These values are expected to be the smallest ones among a great variety of known electron-capture precursors. Therefore, these nuclides are strong candidates for an improved electron-neutrino mass determination. We ask for 8 shifts of on-line beam at ISOLDE for mass measurements of $^{194}$Hg, $^{194}$ Au, $^{202}$Pb, and $^{202}$Tl at ISOLTRAP.

  7. Genomic polymorphism and protein changes of soybean mutant induced by space environment (United States)

    He, J.; Gao, Y.; Sun, Y.

    Soybean 194 4126 of excellent agricultural qualities such as high yield and rounder and wider leaf was selected in six generation after abroad recoverable satellite 15 days in 1996 from Soybean 72163 featured with long-leaf white-blossom grey-hair and infinitude-poding To explore the mechanisms of plant mutation induced by space environment we have experimented at genome and proteome level on Soybean 194 4126 and its control Soybean 72163 Amplified Fragment Length Polymorphism AFLP was used to identify mutated sits and the result shows that 36 polymorphic bands varying between 100 and 900 bp in 2022 DNA bands varying between 100 and 1500 bp have been amplified out of 64 pairs of primer combinations between mutant Soybean 194 4126 and the control plant So the mutation degree of DNA is 3 56 The protein two-dimensional electrophoresis 2-DE and peptide mass fingerprint PMF assays were used to investigate the difference of proteins in fruits and leaves between Soybean 194 4126 and its control Results indicate that 62 protein dots specially appear in Soybean 72163 and 39 dots specially in the mutant Soybean 194 4126 by image analysis software PDQuest in the 2-DE maps of soybean seeds Using PMF assay and protein data-base searching to investigate two distinct protein dots we found that the protein specially expressed in the seed of mutant Soybean 194 4126 may be Dehydrin and the other protein specially expressed in the seed of the control Soybean 72163 may be maturation-associated protein MAT1 Because Dehydrin and MAT1 are

  8. Modeling and Re-Engineering of Azotobacter vinelandii Alginate Lyase to Enhance Its Catalytic Efficiency for Accelerating Biofilm Degradation (United States)

    Jang, Chul Ho; Piao, Yu Lan; Huang, Xiaoqin; Yoon, Eun Jeong; Park, So Hee; Lee, Kyoung; Zhan, Chang-Guo; Cho, Hoon


    Alginate is known to prevent elimination of Pseudomonas aeruginosa biofilms. Alginate lyase (AlgL) might therefore facilitate treatment of Pseudomonas aeruginosa-infected cystic fibrosis patients. However, the catalytic activity of wild-type AlgL is not sufficiently high. Therefore, molecular modeling and site-directed mutagenesis of AlgL might assist in enzyme engineering for therapeutic development. AlgL, isolated from Azotobacter vinelandii, catalyzes depolymerization of alginate via a β-elimination reaction. AlgL was modeled based on the crystal structure template of Sphingomonas AlgL species A1-III. Based on this computational analysis, AlgL was subjected to site-directed mutagenesis to improve its catalytic activity. The kcat/Km of the K194E mutant showed a nearly 5-fold increase against the acetylated alginate substrate, as compared to the wild-type. Double and triple mutants (K194E/K245D, K245D/K319A, K194E/K245D/E312D, and K194E/K245D/K319A) were also prepared. The most potent mutant was observed to be K194E/K245D/K319A, which has a 10-fold improved kcat value (against acetylated alginate) compared to the wild-type enzyme. The antibiofilm effect of both AlgL forms was identified in combination with piperacillin/tazobactam (PT) and the disruption effect was significantly higher in mutant AlgL combined with PT than wild-type AlgL. However, for both the wild-type and K194E/K245D/K319A mutant, the use of the AlgL enzyme alone did not show significant antibiofilm effect. PMID:27253324

  9. Polymorphisms in DNA Repair Genes and Susceptibility to Glioma in a Chinese Population

    Directory of Open Access Journals (Sweden)

    Jun-Hong Guan


    Full Text Available The excision repair cross-complementing rodent repair deficiency complementation group 1 (ERCC1, and X-ray repair cross-complementing group 1 (XRCC1 genes appear to protect mammalian cells from the harmful effects of ionizing radiation. We conducted a large case-control study to investigate the association of polymorphisms in ERCC1 C118T, ERCC1 C8092A, XRCC1 A194T, XRCC1 A194T, and XRCC3 C241T, with glioma risk in a Chinese population. Five single nucleotide polymorphisms (SNPs were genotyped, using the MassARRAY IPLEX platform, in 443 glioma cases and 443 controls. Association analyses based on an χ2 test and binary logistic regression were performed to determine the odds ratio (OR and a 95% confidence interval (95% CI for each SNP. For XRCC1 Arg194Trp, the variant genotype T/T was strongly associated with a lower risk of glioma cancer when compared with the wild type C/C (OR = 2.45, 95% CI = 1.43–4.45. Individuals carrying the XRCC1 399A allele had an increased risk of glioma (OR = 1.33, 95% CI = 1.02–1.64. The XRCC3 241T/T genotype was associated with a strong increased glioma risk (OR = 3.78, 95% CI = 1.86–9.06. Further analysis of the interactions of two susceptibility-associated SNPs, XRCC1 Arg194Trp and XRCC3 Thr241Met, showed that the combination of the XRCC1 194T and XRCC3 241T alleles brought a large increase in glioma risk (OR = 2.75, 95% CI = 1.54–4.04. XRCC1 Arg194Trp, XRCC1 Arg399Gln, and XRCC3 C241T, appear to be associated with susceptibility to glioma in a Chinese population.

  10. Molecular genetic analysis of pyridoxine-nonresponsive homocystinuric siblings with different blood methionine levels during the neonatal period



    Two mutations in the cystathionine β-synthase (CBS) gene were found in two Japanese siblings with pyridoxine non-responsive homocystinuria who had different methionine levels in their blood during the neonatal period. Both patients were com-pound heterozygotes of two mutant alleles:one had an A-to-G transition at nucleotide194 (A194G) that caused a histidine-to-arginine substitution at position 65 of the protein (H65R), while the other had a G-to-A transition at nucleotide346 (G346A) which re...

  11. DoD Officials did Not Take Appropriate Action When Notified of Potential Travel Card Misuse at Casinos and Adult Entertainment Establishments (United States)


    Committee on Armed Services request letter. 1 Public Law 112-194, “Government Charge Card Abuse Prevention Act of 2012,” October 5, 2012...use at establishments or for purposes that are inconsistent with the official business of DoD or its standards of conduct. Improper Travel Voucher...program and travel card misuse. • Public Law 112-194, “Government Charge Card Abuse Prevention Act of 2012,” October 5, 2015 • DoD 7000.14-R, “Financial

  12. Impacto del virus de la leucosis bovina en la producción de leche


    Cadavid Gutierrez , Lascario Artemo


    El objetivo del estudio fue determinar la prevalencia de Leucosis Viral Bovina (LVB) en vacas lecheras y establecer si existía una relación directa con la producción de leche. Se trabajo con 194 animales de la raza Holstein y Jersey (1-5 partos), en 9 hatos ubicados en la zona central del departamento del Valle del Cauca. Las 194 muestras de sangre fueron procesadas en el laboratorio de biología molecular de la Universidad Nacional de Colombia, donde se detecto el virus mediante la técnica de...



    N. N. Temirov; N. E. Temirov


    Aim. To analyze visual acuity, clinical refraction, and defocusing tolerance after the implantation of monofocal IOL with rotational asymmetric optic (Lentis Mplus 313 MF) compared with Acrysof ReSTOR SN6AD1.Materials and methods. Phacoemulsification was performed in a total of 194 patients (288 eyes), i.e., 144 patients (188 eyes) with cataract and 50 patients (100 eyes) with presbyopia and high ametropia. The patients were divided into two groups. Study group included 132 patients (194 eyes...

  14. Noise Attenuation Performance of the Lightning II Generation II Helmet When Worn in Combination with the Joint Service Aircrew Mask (JSAM)-Joint Strike Fighter (JSF) (United States)


    measurements for participating subjects Subject ID Anthropometric Head and Neck Measurements (cm) Head Circumference Head Length Head Width Nasal...Root to Supramentale Neck Circumference 1438* 57.7 19.4 15.5 88.9 36.1 1524* 57.0 19.3 15.5 82.5 40.5 1526* 57.0 19.4 16.0 82.0 42.5 1572* 62.5...3 Table 2. Anthropometric head and neck measurements for participating subjects* ...................... 4 Table 3. Gen

  15. Domain Modeling: NP_001036146.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001036146.1 chr1 The structure of collagen type I. Single type I collagen molecu...le: rigid refinment c1ygvb_ chr1/NP_001036146.1/NP_001036146.1_holo_191-1185.pdb psi-blast 192E,193V,194P,19

  16. EGF61A>G polymorphism as predictive marker of clinical outcome to first-line capecitabine and oxaliplatin in metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Spindler, Karen-Lise Garm; Andersen, R F; Jensen, Lars Henrik;


    samples. Response was evaluated according to the RECIST. Survival analysis was described by the Kaplan-Meier method and log-rank testing. RESULTS: The overall response rate was 38% and the median overall survival 19.4 months. A favorable outcome was seen in patients with the EGF61A/G genotype compared...

  17. Job Oriented Training: Handleiding Serious Gaming (Job Oriented Training: Handleiding (Handbook) Serious Gaming) (United States)


    Onderwijskundige grondslag en onderbouwing, TNO-DV 2008 A194, TNO Defensie en Veiligheid, Soesterberg. [2] Stubbe- Albers , H.; Hulst, A.H. van der...Educational Researcher, 18-1, jan ./febr. 1989, p. 32-42. [7] Bransford, J.D.; Brown, A.L. & Cocking, R.R. (editors) (2000), How people learn: Brain, Mind

  18. Unbalanced Bidding in Government Contracts (United States)


    Id. at 71213 167. Id. 168. Id. at 71218 169. Nager Electric Co., Inc. v. United States, 194 Ct. Cl. 835 (1971) 170. J. W. Bateson Co. v. United...BCA 13402 (1978) 176. Gregory & Reilley Associates, Inc., FAACAP No. 65-30, 65-2 BCA 4918 (1965) 177. ASBCA no. 18348, 74-2 BCA 10781 (1974) 178. Id. at

  19. Autonomous Sustain and Resupply, Phase 1 Report (United States)


    Res. (JAIR), 20:155-194, 2003. [24] Gregory Dudek and Nicholas Roy. Multi-robot rendezvous in unknown environments, or, what to do when you’re lost...pages 177-186, 2000. [48] Alex Kacelnik and Melissa Bateson . Risky theories - the effects of variance on foraging decisions. American Zoologist, 36

  20. Isolation of Enteric Fever Agents from the Blood (United States)


    Assoc. 50:297.304. 13. Jawetz, E., J. L. Melnick, and E. A. 23. Thomas, J; C., K. C. Watson, and A. Adelberg. 1970. Review of Medical S. Hewstone ...J. Egyptian Pub. Health 30. Wilson, G. S. and A. A. Miles (1975). "" Assoc. 45:181-194. Tofley and Wilson’s Principles of Rae- 20. Schlack, P., M

  1. Parental Behaviors during Family Interactions Predict Changes in Depression and Anxiety Symptoms during Adolescence (United States)

    Schwartz, Orli S.; Dudgeon, Paul; Sheeber, Lisa B.; Yap, Marie B. H.; Simmons, Julian G.; Allen, Nicholas B.


    This study investigated the prospective, longitudinal relations between parental behaviors observed during parent-adolescent interactions, and the development of depression and anxiety symptoms in a community-based sample of 194 adolescents. Positive and negative parental behaviors were examined, with negative behaviors operationalized to…

  2. A Minimum-Residual Finite Element Method for the Convection-Diffusion Equation (United States)


    examples of nonstan- dard discretizations include higher order continuity basis functions (splines and NURBS [34]), and discontinuous functions (DG...analysis: CAD, finite elements, NURBS , exact geometry and mesh refinement. Computer Methods in Applied Mechanics and Engineering, 194(39–41):4135

  3. Variational Multiscale Stabilization of High-Order Spectral Elements for the Convection-Diffusion Equation (United States)


    by Canuto and coworkers in [17, 18, 19, 52], and later by Hughes and coworkers in [21] using non-uniform rational B-splines ( NURBS ). In this paper we...finite elements, NURBS , exact geometry and mesh refinement, Comput. Methods Appl. Mech. Engrg. 194 (2005) 4135–4195. [22] S. Godunov, A difference method

  4. Trade in Services: The Doha Development Agenda Negotiations and U.S. Goals (United States)


    NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Congressional Research Service, Library of Congress,101 Independence Ave...examination of potential results. 1 Information was obtained in a meeting with John Goyer...International Trade in Services: An Overview and Blueprint for Negotiations. American Enterprise Institute. Ballinger Publishers. 1988. p. 194. 10 The

  5. Late Globalization and Evolution and Metamorphoses of Industries

    DEFF Research Database (Denmark)

    Boujarzadeh, Behnam; Turcan, Romeo V.; Dholakia, Nikhilesh


    In this paper we explore the effect of late globalization on evolution of industries. Specifically we investigate the impact of late globalization on the evolution and metamorphoses of Danish Textile and Fashion Industry (DTFI). Using historical data, we survey the development of DTFI between 194...

  6. 75 FR 63462 - Central New York Oil and Gas Company, LLC; Notice of Intent To Prepare an Environmental... (United States)


    ... southward from interconnections with CNYOG's South Lateral and TGP's Line 300 in Bradford County, through... Lateral proposed in Docket No CP10-194-000; The M1-S Compressor Station consisting of 16,360 hp of gas... already identified several issues that we think deserve attention based on a preliminary review of...

  7. AcEST: BP916097 [AcEST

    Lifescience Database Archive (English)

    Full Text Available |PALY_AMAMU Phenylalanine ammonia-lyase OS=Amanita musc... 30 8.8 sp|Q32LL5|INT12_BOVIN Integrator complex s...----AYC 194 >sp|O93967|PALY_AMAMU Phenylalanine ammonia-lyase OS=Amanita muscaria

  8. Gclust Server: 125000 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available lightly similar to metyltransfrases 1 1.00e-99 0.0 0.0 0.0 0.0 3.23 0.0 Show 125000 Cluster ID 125000 Sequen...2) Sequence length 194 Representative annotation putative protein, slightly similar to metyltransfrases

  9. Charismatic aspect of transformational leadership and its role in creating organizational culture / Gerda Mihhailova, Kulno Türk

    Index Scriptorium Estoniae

    Mihhailova, Gerda


    Ettevõtte kasvu- ja küpsusfaasis vajatakse autorite hinnangul enam nn. klassikalisi juhte, karismaatilised juhid sobivad pigem radikaalseid muutusi nõudvatesse situatsioonidesse, nagu näiteks ettevõtte rajamine või selle langusfaasist välja toomine. Skeemid. Tabel. Lisa lk. 194

  10. Christian Commitment and Personal Well Being: Exploring the Connection between Religious Affect and Global Happiness among Young Churchgoers in Australia (United States)

    Francis, Leslie J.; Penny, Gemma


    Drawing on data from the 2011 Australian National Church Life Survey, this study was designed to assess the connection between religious affect (as a measure of Christian commitment) and global happiness (as a measure of personal well being) among a sample of 6,194 young churchgoers in Australia between the ages of 8 and 14 years, attending a…

  11. 75 FR 8431 - Carbon Dioxide Fire Suppression Systems on Commercial Vessels (United States)


    ... Homeland Security Coast Guard 46 Parts 25, 27, 28, et al. Carbon Dioxide Fire Suppression Systems on..., 182, 185, 189, 190, 193, 194, and 196 RIN 1625-AB44 Carbon Dioxide Fire Suppression Systems on... vessels. The amendments would clarify that approved alternatives to carbon dioxide systems may be used...

  12. Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population

    DEFF Research Database (Denmark)

    Berquist, Brian R; Singh, Dharmendra Kumar; Fan, Jinshui


    ) and two frequent (R194W and R399Q) amino acid population variants had little or no effect on XRCC1 protein stability or the interactions with POLbeta, PARP-1, LIG3alpha, PCNA or DNA. One common population variant (R280H) had no pronounced effect on the interactions with POLbeta, PARP-1, LIG3alpha and PCNA...

  13. Dicty_cDB: Contig-U14073-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Bluescript (E... 44 5.9 1 ( DY831708 ) CTOY7192.b1_O22.ab1 CTO(XYZ) dandelion Taraxacum ... 44 5.9 1 ( DY831...194 ) CTOY6720.b1_P23.ab1 CTO(XYZ) dandelion Taraxacum ... 44 5.9 1 ( CJ358095 )

  14. Employed Carers' Empathy towards People with Intellectual Disabilities: The Development of a New Measure and Some Initial Theory (United States)

    Collins, Kirsten; Gratton, Caroline; Heneage, Celia; Dagnan, Dave


    Background: This study aimed to develop a self-report measure of paid caregivers' empathy towards people with intellectual disabilities. Materials and Methods: Following questionnaire development, 194 staff working in services for people with intellectual disabilities completed self-report questionnaires, including the new empathy measure. The…

  15. 76 FR 33277 - Proposed Approval of the Central Characterization Project's Remote-Handled Transuranic Waste... (United States)


    ... Center homepage at . Docket: All documents in the docket are... site other than the Los Alamos National Laboratories (LANL) until the EPA determines that the site has... CFR Part 194); and (2) (with the exception of specific, limited waste streams and equipment at...

  16. Self-Efficacy and Burnout in Professional School Counselors (United States)

    Gunduz, Bulent


    This study investigated the relationships between burnout and self-efficacy among school counselors. Also, the level of their burnout and self-efficacy was examined in terms of the social support, task perception and the number of students. A sample of 194 school counselors filled out the Maslach Burnout Inventory, The School Counselors…

  17. Measuring Two-Event Structural Correlations on Graphs (United States)


    Morgan Kaufmann , 2006. [13] T. Hesterberg. Weighted average importance sampling and defensive mixture distributions. Technometrics, 37(2):185–194, 1995...15] M. Kendall and J. Gibbons. Rank correlation methods. Edward Arnold , 1990. [16] A. Khan, X. Yan, and K. Wu. Towards proximity pattern mining in

  18. 75 FR 64507 - Taking and Importing Marine Mammals; Military Training Activities Conducted Within the Gulf of... (United States)


    ..., ships, and submarines, operating alone or in combination, to locate, track, and neutralize submarines... maximum duty cycle of 30 milliseconds and has a design power of 194 dB re 1 micro-Pascal at 1 meter. Ping.... Total time operated would be 80 hours annually. Transponders--Each transponder package consists of...

  19. The Effects of Dress on School Discipline. (United States)

    Sommers, Norman L.

    This report presents the results of a study to determine the effects of student dress on behavior while at school. The study took place at 5 high schools, 4 junior high schools, and 10 elementary schools during the 2000-01 school year. The total enrollment of the schools was 8,194. The study involved two or three sets consisting of three days…

  20. Evaluation of Neuroprotection and Behavioral Recovery by the Kappa- Opioid, PD 117302 Following Transient Forebrain Ischemia (United States)


    recover at least 50% of baseline most rats, performance degradation was characterized by a com- values was caiculated. Quarter-life measures were...histological changes induced by transient global ce- 34:190-194; 1991. rebral ischemia in rats: Effects of cinnarizine and flunarizine. J. 17. Hall, E. D

  1. 5 CFR 2634.105 - Definitions. (United States)


    ... this part: (a) Act means the Ethics in Government Act of 1978 (Pub. L. 95-521, as amended), as modifed by the Ethics Reform Act of 1989 (Pub. L. 101-194, as amended). (b) Agency means any executive agency... Atmospheric Administration; (2) The Secretary of Health and Human Services, with respect to matters...

  2. Non-weight-bearing status compromises the functional level up to 1 yr after hip fracture surgery

    DEFF Research Database (Denmark)

    Ariza-Vega, Patrocinio; Jiménez-Moleón, José Juan; Kristensen, Morten Tange


    OBJECTIVE: The aim of this study was to examine the influence of weight-bearing (WB) status after hip fracture surgery on 1-yr functional outcome. DESIGN: This was a prospective cohort study, carried out in a public acute hospital trauma service. The 194 patients (36 men and 158 women), with a me...

  3. Conduct Disorder and Initiation of Substance Use: A Prospective Longitudinal Study (United States)

    Hopfer, Christian; Salomonsen-Sautel, Stacy; Mikulich-Gilbertson, Susan; Min, Sung-Joon; McQueen, Matt; Crowley, Thomas; Young, Susan; Corley, Robin; Sakai, Joseph; Thurstone, Christian; Hoffenberg, Analice; Hartman, Christie; Hewitt, John


    Objective: To examine the influence of conduct disorder (CD) on substance use initiation. Method: Community adolescents without CD (n = 1,165, mean baseline age = 14.6 years), with CD (n = 194, mean baseline age = 15.3 years), and youth with CD recruited from treatment (n = 268, mean baseline age = 15.7 years) were prospectively followed and…

  4. Acetonitrile in the air over Europe

    Energy Technology Data Exchange (ETDEWEB)

    Hamm, S.; Helas, G.; Warneck, P.


    A gas chromatographic technique was developed to measure acetonitrile mixing ratios in air samples collected during three aircraft flights over Europe. Uniform mixing ratios were observed in the troposphere independent of altitude, with an average of 144+-26 pptv for the first two flights, and 194+-7 pptv for the third. /copyright/ American Geophysical Union 1989

  5. Acetonitrile in the air over Europe (United States)

    Hamm, S.; Helas, G.; Warneck, P.


    A gas chromatographic technique was developed to measure acetonitrile mixing ratios in air samples collected during three aircraft flights over Europe. Uniform mixing ratios were observed in the troposphere, independent of altitude, with an average of 144 + or - 26 pptv for the first two flights and 194 + or - 7 pptv for the third.

  6. The origins of formal education in sub-Saharan Africa: was British rule more benign?

    NARCIS (Netherlands)

    Frankema, E.H.P.


    British colonial rule has often been praised for its comparatively benign features, such as its support of local educational development. This study argues that the impact of British educational policies and investments on the supply of schooling in British Africa should not be overstated. Until 194

  7. Defeating the United States with Radiological Weapons in Fourth Generation Warfare (United States)


    37 Goiania , Brazil Radiological Incident ...............................................................................38 Three-Mile...Health Physics Society, 2001), 2. 24 Scheider, 194. 25 Alex Neifert, “Case Study: Accidental Leakage of Cesium-137 in Goiania , Brazil, in...cataclysmic economic decline. 36 Evidence from Chernobyl, Goiania , Three-Mile Island, the Washington D.C. snipers, the shark attacks and the

  8. The Attitude Scale towards Distance Nursing Education (AstDNE) (United States)

    Boz Yuksekdag, Belgian; Unsal Barlas, Gul


    In this study, a measurement is seen as an instrument to measure the attitudes of the nurses towards the distance nursing education was developed. The study population consist of nurses who working in two hospitals of the ministry of health and two special hospitals in Istanbul. The sample of the study consisted of 194 nurses who agreed to…

  9. Whom should one thank for a narrow escape? Lessons drawn from a perilous journey from Vormsi and Noarootsi to Finland in 1796 / Jürgen Beyer

    Index Scriptorium Estoniae

    Beyer, Jürgen, 1965-


    Autor analüüsib arhiivimaterjalide ja tekstide erinevusi juhtumitest, kus kaheksa Vormsi ja Noarootsi meest sattusid merel tormi kätte, kuid pääsesid õnnelikult. Lisad lk. 194-195 : Eesti kaart (Andree 1893-96 : 91) ja Haapsalu kihelkond (Mellin 1798 : Der Hapsalsche Kreis)

  10. Evolution of Weakly Nonlinear Water Waves in the Presence of Viscosity and Surfactant (United States)


    Pliny, 77 A.D. Naturalis Historia . Book ii, Chapter 107, section 234. Reynolds, 0. 1880 On the effect of oil on destroying waves on the surface of water...fluid. J. Appl . Mech. Tech. Phy., 9, 190-194. * 36 I 77 7 I LIST OF FIGURES Figure 1. Evolution of modulations for inviscid gravity waves (A = 0) when the

  11. Domain Modeling: NP_001561.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001561.3 chr3 Structural Basis for the Interaction of TAK1 Kinase with its Activ...ating Protein TAB1 p2evaa_ chr3/NP_001561.3/NP_001561.3_holo_194-543.pdb psi-blast 216I,217S,218Q,219G,224V,

  12. African and Arab American Achievement Motivation: Effects of Minority Membership. (United States)

    Kovach, Bernadette S.; Hillman, Stephen B.

    The association between ethnic group identification, attributional style, and the use of self-protective attributions with respect to self-esteem, academic achievement and motivation among ethnically diverse adolescents was examined. Participants in the study included 422 African American, 90 Arab American, and 194 European American high school…

  13. Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome.

    NARCIS (Netherlands)

    Nagtegaal, J.E.; Laurant, M.W.; Kerkhof, G.A.; Smits, M.G.; Meer, Y.G.; Coenen, A.M.L.


    Compared health-related quality of life of 43 delayed sleep phase syndrome (DSPS) patients (mean age 34.1 yrs) with a random Dutch sample of 1,063 Ss (aged 18-89 yrs) and 95 sleep apnea, 262 clinical depression, 546 migraine, and 194 osteoarthritis patients. The effectiveness of treatment with 5 mg

  14. Slaaphouding en toedekken van zuigelingen in het najaar van 1994 [Sleeping positions and bed clothes of infants in the autumn of 1994

    NARCIS (Netherlands)

    Burgmeijer, R.J.F.; Jonge, G.A. de


    Objective: To determine whether the sleeping position and the use of duvets in infants in 1994 had changed in comparison with earlier years. Design: Questionnaire survey. Setting: Nationwide investigation in infant welfare centres. Method: 194 infant welfare centres participated in the investigation

  15. On some Chiroptera from Greece

    NARCIS (Netherlands)

    Laar, van Vincent; Daan, Serge


    On a trip to Greece between the 25th April and the 25th July 1963, the authors collected (on the mainland and some islands in the Aegean) insects, amphibians and reptiles as well as 194 mammals. Among the mammals, mainly rodents and insectivores, there were also 27 bats, belonging to five species. A

  16. 78 FR 33120 - Final Interim Staff Guidance LR-ISG-2011-04; Updated Aging Management Criteria for Reactor Vessel... (United States)


    ... Evaluation Guidelines (MRP-227-A), dated December 2011 (ADAMS Accession No. ML12017A193 [Transmittal letter from the EPRI-MRP] and ADAMS Accession Nos. ML12017A194, ML12017A196, ML12017A197, ML12017A191... ensure consistency with MRP-227-A and provides a framework to ensure that PWR license renewal...

  17. Examining Intrinsic Thalamic Resting State Networks Using Graph Theory Analysis : Implications for mTBI detection (United States)


    al., “Functional disintegration in paranoid schizophrenia using resting-state fMRI”, Schiz. Res, vol. 97, pp. 194–205, 2007. [24] L.Q. Uddin, et al...disruptions in the resting state networks and neurocognitive pathologies such as schizophrenia , Alzheimer’s disease and attention deficit hyperactive

  18. Corporal Punishment in Tanzania's Schools (United States)

    Feinstein, Sheryl; Mwahombela, Lucas


    The purpose of this survey was to acquire descriptive information regarding corporal punishment in Tanzania's O-level secondary schools. 448 individuals participated in the study: 254 teachers and 194 students, all from government or private secondary schools in the Iringa Region of Tanzania. In addition, 14 students and 14 teachers were…

  19. Optical closure of apparent optical properties in coastal waters off Goa

    Digital Repository Service at National Institute of Oceanography (India)

    Talaulikar, M.; Suresh, T.; Desa, E.S.; Inamdar, A.

    phase function for ocean water. Ocean Optics XII. J. S. Jaffe, ed., Proc. SPIE 2258, 194. Gordon, H. R., Brown J. W., & Evans, R. H. (1988). Exact Rayleigh scattering calculations for use with the Nimbus-7 Coastal Zone Color Scanner, Applied Optics...

  20. An Investigation into Ambiguity Tolerance in Iranian Senior EFL Undergraduates (United States)

    Marzban, Amin; Barati, Hossein; Moinzadeh, Ahmad


    The present study aimed to explore how tolerant of ambiguity Iranian EFL learners at university level are and if gender plays a role in this regard. To this end, upon filling in the revised SLTAS scale of ambiguity tolerance 194 male and female Iranian teacher trainees were assigned to three ambiguity tolerance groups; namely, high, moderate and…

  1. Vitamin B12 status is associated to bone mineral content and bone mineral density in frail elderly women, but not in men

    NARCIS (Netherlands)

    Dhonukshe-Rutten, R.A.M.; Lips, M.; Jong, N.; Chin A Paw, M.J.M.; Hiddink, G.J.; Dusseldorp, van M.; Groot, de C.P.G.M.; Staveren, van W.A.


    Subclinical vitamin B-12 deficiency is common in the elderly. Encouraged by early indications, we investigated the plasma vitamin B-12 status in association with bone mineral content (BMC) and bone mineral density (BMD) in frail elderly people. Data of 194 free-living Dutch frail elderly (143 women

  2. The Prevalence of Injuries in Professional Turkish Soccer Players (United States)

    Yamaner, Faruk; Gumusdag, Hayrettin; Kartal, Alparslan; Gumus, M.; Gullu, A.; Imamoglu, O.


    Study aim: To assess the prevalence and anatomical sites of injuries in professional soccer players in one game season. Material and methods: A cohort of 510 professional male soccer players consisting of 48 goalkeepers, 194 defence players, 189 mid-field players and 79 forward players of the 1st and 2nd Turkish Professional Soccer Leagues in…

  3. The color-magnitude relation in CL 1358+62 at z=0.33 : Evidence for significant evolution in the S0 population

    NARCIS (Netherlands)

    van Dokkum, PG; Franx, M; Kelson, DD; Illingworth, GD; Fisher, D; Fabricant, D


    We use a large, multicolor mosaic of HST WFPC2 images to measure the colors and morphologies of 194 spectroscopically confirmed members of the rich galaxy cluster CL 1358 + 62 at z = 0.33. We study the color-magnitude (CM) relation as a function of radius in the cluster to a limit of 416 from the ce

  4. The Effects on Students' Conceptual Understanding of Electric Circuits of Introducing Virtual Manipulatives within a Physical Manipulatives-Oriented Curriculum (United States)

    Zacharia, Zacharias C.; de Jong, Ton


    This study investigates whether Virtual Manipulatives (VM) within a Physical Manipulatives (PM)-oriented curriculum affect conceptual understanding of electric circuits and related experimentation processes. A pre-post comparison study randomly assigned 194 undergraduates in an introductory physics course to one of five conditions: three…

  5. Xinjiang:Cotton Yield Down 21.3%

    Institute of Scientific and Technical Information of China (English)


    Under the impact of policy adjustment and market recession, the larg-est cotton region Xinjiang reported coverage of 20.156 million mu, down 19.4%. The yeild is estimated to be 2.3746 million tons, down 21.3%

  6. The Baloch-Islamabad Tensions: Problems of National Integration (United States)


    These policies have been a constant source of angst among the Baloch. 194 Robert Repetto , "Optimal...2009). 85 Ramachandran, Sudha. “China’s Pearl in Pakistan’s Waters.” Asia Times Online, May 4, 2005. Repetto , Robert. "Optimal Export Taxes in the

  7. 14 CFR Sec. 19-5 - Air transport traffic and capacity elements. (United States)


    ... AIR CARRIERS Operating Statistics Classifications Sec. 19-5 Air transport traffic and capacity elements. (a) Within each of the service classifications prescribed in section -19-4, data shall be... equipment. The number of days that aircraft owned or acquired through rental or lease (but not...

  8. File list: InP.Liv.10.AllAg.Liver_tumor [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Liv.10.AllAg.Liver_tumor mm9 Input control Liver Liver tumor SRX1008193,SRX1008...194 ...

  9. 78 FR 72932 - Joint Industry Plan; Notice of Filing and Immediate Effectiveness of Amendment No. 31 to the... (United States)


    ... after market close (to service pending retransmission requests) Updated multicast port restriction range...: Quotes: 194,102mps Trades: 36,102mps Completed a participant connectivity request Implemented throttling... 175 Mbps Implemented a connectivity request for BATS and BATS-Y April--Implemented UTDF Capacity...

  10. Dicty_cDB: AFO739 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available F429969 |pid:none) Homo sapiens cyclin-box carrying p... 197 6e-49 AF465728_1( AF465728 |pid:none) Homo sapi...yclin fold prote... 194 8e-48 AF413522_1( AF413522 |pid:none) Homo sapiens cyclin-box carrying

  11. The genome of the pear (Pyrus bretschneideri Rehd.)

    DEFF Research Database (Denmark)

    Wu, Jun; Wang, Zhiwen; Shi, Zebin


    The draft genome of the pear (Pyrus bretschneideri) using a combination of BAC-by-BAC and next-generation sequencing is reported. A 512.0-Mb sequence corresponding to 97.1% of the estimated genome size of this highly heterozygous species is assembled with 194× coverage. High-density genetic maps ...

  12. 33 CFR 164.03 - Incorporation by reference. (United States)


    ... Electrotechnical Commission (IEC), 3, rue de Varemb, Geneva, Switzerland. IEC 61993-2, Maritime navigation and... Services, 655 Fifteenth Street, NW., Suite 300, Washington, DC 20005 (1) RTCM Paper 12-78/DO-100, Minimum Performance Standards, Loran C Receiving Equipment, 1977 164.41 (2) RTCM Paper 194-93/SC104-STD,...

  13. Biokompatibilität (United States)

    Wintermantel, Erich; Shah-Derler, Brigitte; Bruinink, Arie; Petitmermet, Marc; Blum, Janaki; Ha, Suk-Woo

    Eine Zusammenstellung harmonisierter Normen ist in der ISO 10993 gegeben, welche vom technischen Komitee 194 der Internationale Standard Organisation (ISO) erarbeitet wurde. Die ISO 10993 ist unterteilt in verschiedene Unternormen. ISO 10993-1 - Guidance on selection of tests - umfasst Richtlinien zur Betrachtung der Sicherheit von medizinischen Instrumenten und Implantaten.

  14. Impact of Diversity on the Civil-Military Relationship (United States)


    Huntington, 165. 38 Marvin Kriedberg and Henry Merton , History of Military Mobilization in the United States Army, Department of the Army, November 1955...and Merton , 192-194. 49 Millett and Maslowski, 471 50 Johnson and Metz, 210. 17... Merton , 239-246. 86 Ibid., 239-246. 87 Griffith and Griffith Jr., 6-13. 88 Ibid. 30 the

  15. The course of tardive dystonia in Afro Caribbean patients, a population-based study - The Curacao Extrapyramidal Syndromes Study : VII

    NARCIS (Netherlands)

    van Harten, P. N.; Matroos, G. E.; Van Os, J.


    Tardive dystonia (TDt) is a severe side effect of long-term use of antipsychotics. Previous publications suggested that TDt persist but the results are distorted by referral bias. In a population-based nine-year follow-up study (one baseline, six follow-ups) of chronic psychiatric patients (N=194) o

  16. Gclust Server: 160096 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 160096 CEL_T03G11.8_17570635 Cluster Sequences - 194 zig-6: 2 (Zwei) IG-domain protein family member (zig...4 Representative annotation zig-6: 2 (Zwei) IG-domain protein family member (zig-

  17. On D’Arcythompsonia neglecta, a new Harpacticid Copepod from brackish water in Holland

    NARCIS (Netherlands)

    Redeke, H.C.


    Among the notes and collections that came to the Zoological Museum, Amsterdam, after Dr H. C. REDEKE’s death in 1945, I found an entirely completed manuscript, dealing with a new D’Arcythompsonia found in a canal at Den Helder (Netherlands). This is the species cited as nomen nudum by KARL LANG (194

  18. Hispanics in Fast Food Jobs. (United States)

    Charner, Ivan; Fraser, Bryna Shore

    A study examined the employment of Hispanics in the fast-food industry. Data were obtained from a national survey of employees at 279 fast-food restaurants from seven companies in which 194 (4.2 percent) of the 4,660 respondents reported being Hispanic. Compared with the total sample, Hispanic fast-food employees were slightly less likely to be…

  19. 19 CFR 191.192 - Certification for compliance program. (United States)


    ... program. (c) Broker certification. A Customs broker may be certified as a participant in the drawback compliance program only on behalf of a given claimant (see § 191.194(b)). To do so, a Customs broker who is... 19 Customs Duties 2 2010-04-01 2010-04-01 false Certification for compliance program....

  20. Nachbar zweier deutscher Staaten. Dänemark, die Bundesrepublik und die DDR

    DEFF Research Database (Denmark)

    Lammers, Karl Christian

    Artiklen omhandler den danske politik over for de to tyske stater fra 1949. Danmark var eneste NATO- land, der under den Kolde Krig havde grænser til begge tyske stater, og det stillede Danmark i en særlig position.   The article treats with Danish politics towards the two German states after 194...

  1. Regulation of Calcium Fluxes and Apoptosis by BCL-2 Family Proteins in Prostate Cancer Cells (United States)


    Carcinogenesis 2004;25:1089–97. 51. Scaffidi C, Volkland J, Blomberg I, Hoffmann I, Krammer PH, Peter ME. Phosphorylation of FADD/ MORT1 at serine 194 and...association with a 70-kDa cell cycle-regulated protein kinase. J Immunol 2000;164: 1236–42. 52. Alappat EC, Volkland J, Peter ME. Cell cycle effects by C

  2. Dicty_cDB: Contig-U06184-1 [Dicty_cDB

    Lifescience Database Archive (English)


  3. Valg af organisationsform - om betydningen af tradition, tilfældighed og mode

    DEFF Research Database (Denmark)

    Fode, Carsten; Munck, Noe


    in 194 CHF patients, and compared plasma levels with those of 98 age-matched healthy controls. a-Defensin levels were twice as high among CHF patients in New York Heart Association (NYHA) functional class III-IV than in patients in NYHA class I-II and healthy controls (P = 0.001). The absolute increase...

  4. Glucose dehydrogenase polymorphism in man. (United States)

    King, J; Cook, P J


    An isoelectric focusing method for human GDH is described which reveals seven GDH phenotypes. Family studies demonstrate that the variation is genetically determined by three alleles at an autosomal locus with gene frequencies GDH1 = 0.723, GDH2 = 0.194, GDH3 = 0.083. Linkage analysis shows that GDH may be closely linked to PGD on chromosome 1.

  5. 酸性および塩基性物質に対する柿タンニンゲルの吸着特性に関する研究


    ラ, オデ, アハマド


    博士論文要旨Abstract 以下に掲載:Food Science and Technology 19(4) pp697-703 2013. Elsevier. 共著者:La Ode AHMAD, Le Hoang My LINH, Mio AKIMOTO, Yusuke KANEKI, Mitsunori HONDA, Mitsuhiro SUDA, Ko-Ki KUNIMOTO

  6. How Reading Strategy Use and Personality Types Are Related? (United States)

    Safdarian, Zahra; Ghyasi, Majid; Farsani, Mohammad Amini


    This study sought to uncover the reading strategies utilized by Iranian undergraduate English Foreign Language (EFL) learners and their relationship with personality types. To this end, 194 university EFL learners were asked to fill out the Myers-Briggs Type Indicator (MBTI) to identify their personality types and answer a reading strategy…

  7. Ajaleht Pravda ja 40 keisri hullu : "40 kiri" sündis siis, kui teisiti enam ei saanud / Lauri Vahtre

    Index Scriptorium Estoniae

    Vahtre, Lauri, 1960-


    Eesti kultuuritegelaste kirjutatud "40 kirjast" 1980. aastal, kus tunti muret Eesti ühiskonna ja kultuuri tuleviku pärast. Artikkel sisaldab kirjale allakirjutanute nimesid. Ilmunud ka rmt.: Vahtre, Lauri. Ajaloo pööripäevad. Tallinn, 2006, lk. 190-194

  8. Drug: D09897 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available VTHQG LSSPVTKSFN RGEC (Disulfide bridge: 23-88; 134-194; H225-L214, Dimer) Peptide Asthma...on hsa04630(3578) Jak-STAT signaling pathway hsa05310(3578) Asthma Target-based classification of drugs [BR:

  9. Retinal layer location of increased retinal thickness in eyes with subclinical and clinical macular edema in diabetes type 2

    DEFF Research Database (Denmark)

    Bandello, Francesco; Tejerina, Amparo Navea; Vujosevic, Stela


    PURPOSE: To identify the retinal layer predominantly affected in eyes with subclinical and clinical macular edema in diabetes type 2. METHODS: A cohort of 194 type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20/35) were examined with Cirrus spectral-doma...

  10. Mutations c.459+1G>A and p.P426L in the ARSA gene : Prevalence in metachromatic leukodystrophy patients from European countries

    NARCIS (Netherlands)

    Lugowska, Agnieszka; Amaral, Olga; Berger, Johannes; Berna, Linda; Bosshard, Nils U; Chabas, Amparo; Fensom, Anthony; Gieselmann, Volkmar; Gorovenko, Natalia G; Lissens, Willy; Mansson, Jan-Eric; Marcao, Ana; Michelakakis, Helen; Bernheimer, Hanno; Ol'khovych, Natalia V; Regis, Stefano; Sinke, Richard; Tylki-Szymanska, Anna; Czartoryska, Barbara


    In this multicentre study, we examined the prevalence of two mutations in the arylsulfatase A (ARSA) gene, i.e., c.459+1G>A and p.P426L, in 384 unrelated European patients presenting with different types of metachromatic leukodystrophy (MLD). In total, c.459+1G>A was found 194 times among the 768 in

  11. Abstinence, Social Norms, and Drink Responsibly Messages: A Comparison Study (United States)

    Glassman, Tavis J.; Kruger, Jessica Sloan; Deakins, Bethany A.; Paprzycki, Peter; Blavos, Alexis A.; Hutzelman, Erin N.; Diehr, Aaron


    Objective: The purpose of this study was to determine which type of prevention message (abstinence, social norms, or responsible drinking) was most effective at reducing alcohol consumption. Participants: The subjects from this study included 194 college students from a public university. Methods: Researchers employed a quasi-experimental design,…

  12. Casparis Barlæi Bogermannvs "Elegchomenos" sive examen epistolæ dedicatoriæ


    Baerle, Kaspar van


    Layoutgetreues Digitalisat der Ausg.: Lugduni Batavorum : Basson, 1615 Standort: Universität Marburg, Bibliothek Religionswissenschaft (510) Signatur: 194 Bemerkungen: Vollst. Titel: Casparis Barlæi Bogermannvs "Elegchomenos" sive examen epistolæ dedicatoriæ : quam suis ad pietatem illust. ord. Hollandiæ ac Westfrisiæ notis præfixit Ioh. Bogermannus Ecclesiastes Leovardiensis (Bibliothek Wittgenstein)

  13. Development of Maintenance METRICS To Forecast Resource Demands of Weapon Systems (Analysis and Evaluation). Revision A. (United States)


    practical, and proved to be the most economical and expeditious method to gather all the data. 8. BASE VISITS At each base as depicted in Figure 9, it was...C) 137 D194-10089-1 A METRICS I ENVIROMENTAL A(PARAIETERS BY BASE) ALTITUDE OF BASE? GEOGRAPHY OF AREA. A) HILLY B) FLAT C) DESERT D) ETC

  14. The role of continuity in residual-based variational multiscale modeling of turbulence

    NARCIS (Netherlands)

    Akkerman, I.; Bazilevs, Y.; Calo, V.M.; Hughes, T.J.R.; Hulshoff, S.


    This paper examines the role of continuity of the basis in the computation of turbulent flows. We compare standard finite elements and non-uniform rational B-splines (NURBS) discretizations that are employed in Isogeometric Analysis (Hughes et al. in Comput Methods Appl Mech Eng, 194:4135–4195, 2005

  15. Parent Reports of Young Spanish-English Bilingual Children's Productive Vocabulary: A Development and Validation Study (United States)

    Mancilla-Martinez, Jeannette; Gámez, Perla B.; Vagh, Shaher Banu; Lesaux, Nonie K.


    Purpose: This 2-phase study aims to extend research on parent report measures of children's productive vocabulary by investigating the development (n = 38) of the Spanish Vocabulary Extension and validity (n = 194) of the 100-item Spanish and English MacArthur-Bates Communicative Development Inventories Toddler Short Forms and Upward Extension…

  16. Shoreline Conditions and Bank Recession Along the U.S. Shorelines of the Saint Marys, Saint Clair, Detroit and Saint Lawrence Rivers, (United States)


    ciety of Photogrammetry Fall Technical Meeting, Wolf, P.R. (1974) Elements of Photogrammetry. Albuquerque, New Mexico , October, p. 194. New York: McGraw... ZEE co z .0 33* Isan FIGURE A2 (cont’id). 0*00 30 5000 O mtr h, 3 LAK *c GEORGE 2 4 statute miles MICHIGAN ONAI 52 v A,- mvc hi mvc Neebish Island h

  17. The use of lipids as phase change materials for thermal energy storage (United States)

    Phase change materials (PCMs) are substances capable of absorbing and releasing large 2 amounts of thermal energy (heat or cold) as latent heat over constant temperature as they 3 undergo a change in state of matter (phase transition), commonly, between solid and 4 liquid phases. Since the late 194...

  18. Discovery: Prime Numbers (United States)

    de Mestre, Neville


    Prime numbers are important as the building blocks for the set of all natural numbers, because prime factorisation is an important and useful property of all natural numbers. Students can discover them by using the method known as the Sieve of Eratosthenes, named after the Greek geographer and astronomer who lived from c. 276-194 BC. Eratosthenes…

  19. Military Standard: Military Training Programs (United States)


    D-21 80. VISUAL - MANAGEMENT (vm) SERVICE GROUP .................. D-22 80.1 Introduction ............................................... D...D.60 110.12.3 194 UNSUPPORTED GRAPHICS MODE ......................... D.60 110.12.4 207 GENERAL VISUAL - MANAGEMENT ERROR .................. D.60...command oganizato 1he ---Maagmet Software shiall include four servic gropsi: system (sy) (see Section 70), visual management (yin) (awe Section 80

  20. Analysis of Chemical Warfare Agents: General Overview, LC-MS Review, In-House LC-ESI-MS Methods and Open Literature Bibliography (United States)


    isopropylaminoethyl O-ethyl methylphosphonothioate in soil sulphur-containing products. Pestic . Sci., 8, 510-514. 194. Kaipainen, A., Kostiainen, O. and...ethyl methylphosphonothioate in soil: Phosphorus containing products. Pestic . Sci., 7, 355-362. DRDC Suffield TR 2006-022 73 413. Verweij

  1. Living Together: The Impact of the Intifada and the Peace Negotiations on Attitudes toward Coexistence of Arab and Jewish Pupils in Ethnically Segregated and Mixed Schools in Jaffa. (United States)

    Zuzovsky, Ruth


    Changes in the willingness of Jews and Arabs to coexist were studied in 1989 with 217 12-year-olds and in 1994 with 194 in Jaffa (Israel), where both Jews and Arabs live. Separatist attitudes increased and faith in coexistence decreased, but mixed schools seemed to improve attitudes toward coexistence. (SLD)

  2. Predictors of Academic Procrastination and University Life Satisfaction among Turkish Sport Schools Students (United States)

    Ocal, Kubilay


    The purpose of this study was to examine the role of burnout, academic self-efficacy and academic success in predicting procrastination and university life satisfaction among sports schools students. The study sample comprised of 224 participants aged from 18 to 30 years with a mean age of 21.71 (SD = 1.94) who were attending various departments…

  3. Reviews

    NARCIS (Netherlands)



    This book is designed as a practical guide for the identification of fossil and extant woods with the aid of a marginally perforated card key, based on the ones devised by Clarke and perfected in the well-known Hardwood and Softwood keys published by the Princes Risborough Laboratory in 1961 and 194

  4. Comparison of early complications using regular mesh versus Atramat and reg; Neoflex 25 mesh in inguinal, umbilical and post incisional hernias

    Directory of Open Access Journals (Sweden)

    Juan Jos and eacute; Granados-Romero


    Conclusions: Using Atramat and reg; Neoflex 25 mesh demonstrated a significant reduction of complications (recurrence and seroma formation and length of hospital stay (2 days vs 1 day in abdominoplasty after surgery. [Int J Res Med Sci 2016; 4(1.000: 194-197

  5. Excitation functions of deuteron-induced nuclear reactions on natural platinum up to 24 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Khandaker, Mayeen Uddin, E-mail: [Department of Physics, University of Malaya, 50603 Kuala Lumpur (Malaysia); Haba, Hiromitsu; Murakami, Masashi [Nishina Center for Accelerator-Based Science, RIKEN, Wako, Saitama 351-0198 (Japan); Otuka, Naohiko [Nuclear Data Section, Division of Physical and Chemical Sciences, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, A-1400 Vienna (Austria); Kassim, Hasan Abu [Department of Physics, University of Malaya, 50603 Kuala Lumpur (Malaysia)


    Excitation functions of the {sup nat}Pt(d,x){sup 192,193,194,195,196m2,196,198m,198,199}Au, {sup 195m,197}Pt and {sup 190(g+m1+0.086m2),192(g+m1),194m}Ir nuclear reactions were measured from the respective threshold up to 24 MeV deuteron energy by using the stacked foil activation technique combined with HPGe gamma-ray spectrometry. Measured data were critically compared with the available literature data and theoretical data extracted from the TENDL-2013 library, and only partial agreement among them was found. Physical thick target yields for the investigated reaction products were also deduced and compared with the directly measured ones in the literature. The deduced yield curves indicate that a low energy cyclotron (<15 MeV) and a highly enriched {sup 198}Pt target could be used to obtain {sup 198,199}Au in no carrier added form. All cross-sections for {sup 190(g+m1+0.086m2),194m}Ir and those for {sup 193,194,196m2,196,199}Au, and {sup 195m,197}Pt in the lower energy region are reported for the first time.

  6. Linguo-Intercultural Sensitivity and Its Predictors in EFL in a Bosnian Sample (United States)

    Aydogan, Hakan; Akbarov, Azamat


    In this article, the predictive power of five variables relevant for Linguo-intercultural sensitivity (flexibility) is examined. Communication aspect of intercultural interactions, specifically, the role of English as an international language are emphasized. Attitudes Towards English and Its Usage Scale (ATEUS) was applied to 194 students who…

  7. Mechanics of Concrete II (United States)


    Mindess (1981) also agrees with the first of the two reactions but allows for transformation of the ettringite to monosulphate in the case when all...Comp. Materials, 23, pp. 163-194. 3 Mindess , S. and J. F. Young (1981), Concrete, Prentice Hall, Englewood Clifs, N.J. * 74 I Moavenzadeh, F.(1971

  8. Self-Regulation of Physical Education Teacher Education Students' Attitudes towards Exercise and Diet (United States)

    Wilkinson, Carol; Prusak, Keven


    The purpose of this study was to assess differences in self-regulation of attitudes towards engaging in exercise and eating a healthy diet between physical education teacher education (PETE) students and general education (GE) students, and between male students and female students. Participants were university students (n = 194) at a university…

  9. 急诊外伤患者清创方法及护理%Emergency Trauma Patients Debridement Treatment Method and Nursing care

    Institute of Scientific and Technical Information of China (English)



    Objective To explore the emergency trauma patients debridement treatment method and nursing care. Methods A retrospective analysis of 194 patients in our hospitaldebridement patients data.Results In 194 patients, 182 cases were healed,phase II healing in 12 cases,1 cases of stage III non healing wounds,24 h in no infection symptoms,debridement effect is good.Conclusion For emergency trauma victims,treatment and nursing quality remains to be improved,the nurse should strictly folow the nursing path,good symptomatic care,family communication, with emphasis on team.%目的:探讨急诊外伤患者清创处理方法及护理。方法回顾性分析我院收治的194例清创患者资料。结果194例患者中,Ⅰ期愈合182例,Ⅱ期愈合12例,无1例Ⅲ期愈合,24 h内创面未出现感染症状,清创效果较好。结论对于急诊外伤患者而言,治疗与护理质量尚有待提高,护士应严格遵照护理路径,做好对症护理、家属沟通工作,注重团队配合。




    ¡a capacidad de los compuestos fenólicos de interactuar con radicales peroxilo es de interés tanto para entender sus procesos de oxidación como para evaluar su rol como antioxidantes en distintos sistemas. En la presente tesis se realizaron una serie de e 194p.

  11. Provenance and tectonic setting of the Triassic Yidun Group, the Yidun Terrane, Tibet

    Directory of Open Access Journals (Sweden)

    Bai-Qiu Wang


    Prominently high Zr/Sc ratio or Hf concentration and Paleoproterozoic Nd modal ages (1.94–2.21 Ga point to input of recycling components derived from old sedimentary source in a relatively stable tectonic setting.

  12. European Science Notes Information Bulletin Reports on Current European and Middle Eastern Science (United States)


    History," British J. Clinical Pharma - Tucson, AZ, June 3-8, 1990. cology 29 187-194(1990). 26. C. Offidani, A. Carnevale, and M. Chiarotti, 21. W...compound semiconductors Fraunhofer-Institut fir Integrierte Schaltungen (IS) electron spin resonance and Raman spec- (Fraunhofer Institute for Integrated

  13. Moderating Effects of Aggression on the Associations between Social Withdrawal Subtypes and Peer Difficulties during Early Adolescence (United States)

    Bowker, Julie C.; Markovic, Andrea; Cogswell, Alex; Raja, Radhi


    Recent research has revealed significant heterogeneity in the peer difficulties associated with social withdrawal subtypes during early adolescence, but little is known about possible sources of that heterogeneity. This study of 194 Indian young adolescents (48% female; 90% Hindu; M age = 13.35 years) evaluated whether the peer adversity related…

  14. “Bad Romance”: Links between Psychological and Physical Aggression and Relationship Functioning in Adolescent Couples

    NARCIS (Netherlands)

    Seiffge-Krenke, I.; Burk, W.J.


    Assortative mating is an important issue in explaining antisocial, aggressive behavior. It is yet unclear, whether the similarity paradigm fully explains frequent displays of aggression in adolescents’ romantic relationships. In a sample of 194 romantic partner dyads, differences between female and

  15. Früher Beginn: Aggression bei jugendlichen Paaren und ihr Bezug zu Partnerschaftsqualität und Bewältigung von Konflikten [Early start: Aggression in adolescent couples and its link to relationship quality and coping with conflicts

    NARCIS (Netherlands)

    Seiffge-Krenke, I.; Burk, W.J.


    Aggressive behavior in adult couples is a problem which must be taken seriously and is a frequent reason for psychotherapy and counseling. Less is known about an early start of aggression, e.g. in adolescent romantic relationships. In a sample of 194 romantic partner dyads (age 16-18 years) differen

  16. Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids, may increase birthweight by prolonging gestation

    DEFF Research Database (Denmark)

    Olsen, S.F.; Hansen, Harald S.; Sørensen, T.I.


    Birthweights in the Faroe Islands are among the highest in the world. Compared with Denmark, the average birthweight of liveborn singleton infants of primiparous mothers in 194 g higher, and a substantial part of this difference seems to be attributable to longer gestation. Prostaglandins play...

  17. A substantial proportion of microsatellite-unstable colon tumors carry TP53 mutations while not showing chromosomal instability

    NARCIS (Netherlands)

    Westra, JL; Boven, LG; van der Wes, P; Faber, H; Sikkema, B; Schaapveld, M; Dijkhuizen, T; Hollema, H; Buys, CHCM; Plukker, JTM; Kok, K; Hofstra, RMW


    Chromosomal instability in colon tumors implies the presence of numerical and structural chromosome aberrations and is further characterized by the absence of microsatellite instability and the occurrence of KRAS and/or TP53 mutations. In a previous screening of 194 colon tumors for both microsatell

  18. Corrigendum to: "Cooling dynamics of photo-excited negative carbon cluster ions stored in an ion storage ring" [Nucl. Instrum. Methods B 354 (2015) 192-196 (United States)

    Furukawa, T.; Ito, G.; Goto, M.; Majima, T.; Tanuma, H.; Matsumoto, J.; Shiromaru, H.; Hansen, K.; Azuma, T.


    In page 194, the definition of σi involves an erroneous factor ln(10). The plot of the theoretical vibrational cooling rate in Fig. 2(b), which is presented on a logarithmic scale, should be slightly shifted by this factor.

  19. Stereotype Threat and Gender Differences in Performance on a Novel Visuospatial Task (United States)

    Campbell, Susan Miller; Collaer, Marcia L.


    Stereotype threat research has shown that being a member of a negatively stereotyped group may result in impaired performance on tests of skills thought to be relevant to the stereotype. This study investigated whether stereotype threat influences gender differences in performance on a novel test of visuospatial ability. Undergraduates (N = 194)…

  20. AcEST: BP912286 [AcEST

    Lifescience Database Archive (English)

    Full Text Available OS=Homo sapiens GN=SRCAP PE... 72 3e-12 sp|Q9NDJ2|DOM_DROME Helicase domino OS=Drosophila melanogaster G... ...VGQTE+YS +L++ Sbjct: 194 IASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQ 249 >sp|Q9NDJ2|DOM_DROME Helicase domino

  1. Profiles of Motivated Self-Regulation in College Computer Science Courses: Differences in Major versus Required Non-Major Courses (United States)

    Shell, Duane F.; Soh, Leen-Kiat


    The goal of the present study was to utilize a profiling approach to understand differences in motivation and strategic self-regulation among post-secondary STEM students in major versus required non-major computer science courses. Participants were 233 students from required introductory computer science courses (194 men; 35 women; 4 unknown) at…

  2. The dark side of romantic relationships: Aggression in adolescent couples and links to attachment

    NARCIS (Netherlands)

    Seiffge-Krenke, I.; Burk, W.J.


    This study focuses on romantic relationships from the perspective of both partners. This dyadic approach was chosen to account for the fact that both partners may differently contribute to the escalation of aggression. In a sample of 194 romantic partner dyads, differences between female and male pa

  3. Friends or lovers? Person- and variable-oriented perspectives on dyadic similarity in adolescent romantic relationships

    NARCIS (Netherlands)

    Seiffge-Krenke, I.; Burk, W.J.


    Variable- and person-oriented approaches were used to examine the affiliative and romantic experiences of adolescents in heterosexual romantic relationships and its associations with relationship conflict and jealousy on a sample of 194 romantic partner dyads. Variable-oriented findings indicated th

  4. Quantitative perfusion parameters in a cohort of patients with no known ischemic heart disease and normal myocardial perfusion imaging studied by 82Rb-PET

    DEFF Research Database (Denmark)

    Hoff, Camilla; Balche, Abdallah; Majgaard, J

    commercially available software (QPET, Cedars Sinai). Parameters included were regional and global rest and stress myocardial blood flow (MBF) values, ejection fraction (EF) and total perfusion deficit (TPD). Results Mean global MBF at stress was 2.92 mL/g/min (±SD 0.49), lower limit (LL) 1.94 m...

  5. Ecology of phytoplankton from Dharmatar Creek, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Tiwari, L.R.; Nair, V.R.

    was vertically mixed except during the monsoon period and nutrients never became a limiting factore for phytoplankton production. Concentration of chlorophyll a and phaeophytin were fairly high, (av. 1.94 and 1.89 mg m sup(-3) respectively). A total of 58 general...

  6. Synthesis and Properties of Trisubstituted Trinitrobenzenes. TATB Analogs. (United States)


    which include a high density (1.94 g/cm ), high thermal stability, a heat of detonation comparible to TNT, and an extremely low impact sensitivity...molecule on impact sensitivity and density, as well as other properties of interest such as chemical and thermal stability, and chemical energy ( heat of detonation ). In

  7. AcEST: DK957955 [AcEST

    Lifescience Database Archive (English)


  8. Long the fixation of physicists worldwide, a tiny particle is found

    CERN Multimedia


    "After decades of intensive effort by both experimental and theoretical physicists worldwide, a tiny particle with no charge, a very low mass and a lifetime much shorter than a nanosecond, dubbed the "axion", has now been detected by the University at Buffalo physicist who first suggested its existence in a little-read paper as early as 194." (2 pages)

  9. Medical Surveillance Monthly Report (MSMR). Volume 8, Number 3, May 2002 (United States)


    events3 Giardia Hepatitis B Varicella 2. Events reported by June 7, 2001 and 2002. Shigella Sentinel reportable events for all beneficiaries1 at US population (n=194, attack rate=1,025/100,000 population) at Fort Leonard Wood was undertaken as directly observed therapy in a single morning

  10. Aggregation studied by laser diffraction in relation to plowing and liming in the Cerrado region in Brazil

    NARCIS (Netherlands)

    Westerhof, R.; Buurman, P.; Griethuysen, van C.; Ayarza, M.; Vilela, L.; Zech, W.


    In the Cerrado savanna region in Brazil, the effects of different land use on axisol aggregation were studied using laser diffraction grain size analyses. The topsoil of plowed systems had significantly lower amount of macroaggregates (2000-194 μm) and a significantly higher amount of soil in the mi

  11. Monetka iz-za morja / Josef Kats

    Index Scriptorium Estoniae

    Kats, Josef, 1977-


    Eesti Panga president Andres Lipstok ja Soome Rahapaja OY tegevdirektor Raimo Makkonen allkirjastasid 19. detsembril mündivermimise lepingu, mille kohaselt vermib Eesti euromündid Rahapaja OY. Ettevõte vermib Eestile 194 miljonit euromünti

  12. Population genetic structure in farm and feral American mink (Neovison vison) inferred from RAD sequencing-generated single nucleotide polymorphisms

    DEFF Research Database (Denmark)

    Thirstrup, Janne Pia; Ruiz-Gonzalez, Aritz; Pujolar, José Martin


    Feral American mink populations (Neovison vison), derived from mink farms, are widespread in Europe. In this study we investigated genetic diversity and genetic differentiation between feral and farm mink using a panel of genetic markers (194 SNP) generated from RAD sequencing data. Sampling incl...

  13. Domain Modeling: NP_683704.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_683704.1 chr1 Crystal Structure of DDB1 In Complex with Simian Virus 5 V Protein p2b5lc_ chr1/NP_683704....1/NP_683704.1_holo_16-196.pdb forte 168P,171T,190S,192D,193D,194R _ZN 0 ...

  14. Domain Modeling: NP_002594.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_002594.1 chr8 Multiple Determinants for Inhibitor Selectivity of Cyclic Phosphodiesterases p1zkla_ chr8/NP_002594.1/NP_002594.1_holo_113-429.pdb blast 185Y,186H,190H,194V,226H,2

  15. From Caterpillar to Butterfly: A Window for Looking into Students' Ideas about Life Cycle and Life Forms of Insects (United States)

    Cinici, Ayhan


    The purpose of this study was a qualitative analysis of high school students' ideas about life cycle and life forms of the butterfly. For this purpose, open-ended questions and drawing methods were applied to 194 high school students from the ninth to eleventh grades and 14 to 16 years of age in Erzurum, Turkey. Students' drawings were categorised…

  16. Contact sensitization to 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (MCI/MI). A European multicentre study

    DEFF Research Database (Denmark)

    Menné, T; Frosch, P J; Veien, Niels


    , formaldehyde, paraben-mix, and MCI/MI. 19.4% of the patients had positive patch tests to nickel, making this the most common allergen. 3% of the patients reacted to 100 ppm MCI/MI, while 2.6% reacted to formaldehyde and 1.1% to parabens. There was great variation in the frequency of MCI/MI sensitivity among...

  17. Disease: H00548 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available pers HH, Hamel BC X-linked mental retardation. Nat Rev Genet 6:46-57 (2005) PMID:8862875 Brunner HG MAOA deficiency and abnormal beha...viour: perspectives on an association. Ciba Found Symp 194:155-64; discussion 164-7 (1996) ...

  18. Carbon dioxide emissions from the tropical Dowleiswaram Reservoir on the Godavari River, Southeast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Prasad, M.H.K.; Sarma, V.V.S.S.; Sarma, V.V.; Krishna, M.S.; Reddy, N.P.C.

    for the Determination of Phytoplankton Chlorophyll Using N, N-Dimethylformamide,” Journal of Oceanography, Vol. 46, No. 4, 1990, pp. 190-194. [40] A. G. Dickson and C. Goyet, “Hand Book of Methods for the Analysis of the Various Parameters of the Carbon Dioxide...

  19. Influence of river discharge on plankton metabolic rates in the tropical monsoon driven Godavari estuary, India

    Digital Repository Service at National Institute of Oceanography (India)

    Sarma, V.V.S.S.; Gupta, S.N.M.; Babu, P.V.R.; Acharyya, T.; Harikrishnachari, N.; Vishnuvardhan, K.; Rao, N.S.; Reddy, N.P.C.; Sarma, V.V.; Sadhuram, Y.; Murty, T.V.R.; Kumar, M.D.

    , 83-93. Suzuki, R., and Ishimaru, T., 1990. An improved method for the determination of phytoplankton chlorophyll using N,N-dimethylformamide. Journal of Oceanography 46, 190-194. 16 Swaney, D.P., Howarth, R.W., and Butler, T.J., 1999. A...

  20. Reduced river discharge intensifies phytoplankton bloom in Godavari estuary, India

    Digital Repository Service at National Institute of Oceanography (India)

    Acharyya, T.; Sarma, V.V.S.S.; Sridevi, B.; Venkataramana, V.; Bharathi, M.D.; Naidu, S.A.; Kumar, B.S.K.; Prasad, V.R.; Bandyopadhyay, D.; Reddy, N.P.C.; DileepKumar, M.

    for the Determination of Phytoplankton Chlorophyll using N, N-Dimethylformamide Journal of the Oceanographical society of Japan, 46: 190-194. Van Bennekom, A.J. and Salomons, W., 1981. Pathways of nutrients and organic matter from land to ocean through rivers. River...

  1. Distribution of biochemical constituents in the surface sediments of western coastal Bay of Bengal: Influence of river discharge and water column properties

    Digital Repository Service at National Institute of Oceanography (India)

    Kumar, B.S.K.; Sarma, V.V.S.S.; Krishna, M.S.

    for the determination of phytoplankton chlorophyll using N,N-dimethylformamide. J. Oceanogr 46: 190-194 Thornton SF, McManus J (1994) Application of organic carbon and nitrogen stable isotope and C/N ratios as source indicators of organic matter provenance...

  2. Meso-scale atmospheric events promote phytoplankton blooms in the coastal Bay of Bengal

    Digital Repository Service at National Institute of Oceanography (India)

    Maneesha, K.; Sarma, V.V.S.S.; Reddy, N.P.C.; Sadhuram, Y.; Murty, T.V.R.; Sarma, V.V.; DileepKumar, M.

    T 1990 An improved method for the determination of phytoplankton chlorophyll using N,N- dimethylformamide; J. Oceanogr. 46 190–194. UNESCO 1979 Discharges of selected rivers of the World, Paris. Varkey M J, Murty V S N and Suryanarayana A 1996 Phys- ical...

  3. Influence of river discharge on abundance and dissemination of heterotrophic, indicator and pathogenic bacteria along the east coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Prasad, V.R.; Srinivas, T.N.R.; Sarma, V.V.S.S.

    . 64, 928-930. Suzuki, R., Ishimaru, T., 1990. An improved method for the determination of phytoplankton chlorophyll using N,N-dimethylformamide. J. Oceanogr. 46, 190-194. Varkey, M.J., Murty, V.S.N., Suryanarayana, A., 1996. Physical oceanography...

  4. Variations in concentrations and fluxes of dimethylsulfide (DMS) from the Indian estuaries

    Digital Repository Service at National Institute of Oceanography (India)

    Viswanadham, R.; Bharathi, M.D.; Sarma, V.V.S.S.

    . Biogeochemistry 83: 245-275. Suzuki, R., and T. Ishimaru. 1990. An improved method for the determination of phytoplankton chlorophyll using N,N-dimethylformamide. Journal of Oceanography 46: 190-194. Turner, S.M., G. Malin, P. Liss, D.S. Harbour, and P...

  5. Diurnal variability of Synechococcus abundance in Sagami Bay, Japan

    Digital Repository Service at National Institute of Oceanography (India)

    Mitbavkar, S.; Saino, T.

    of phytoplankton chlorophyll using N, N-dimethylformamide. Journal of Oceanographic Society Japan 46: 190–194. Tsai, A., K.P. Chiang, J. Chang, & G.C. Gong, 2005. Seasonal diel variations of picoplankton and nannoplankton in a subtropical western Pacific...

  6. Population ecology and community structure of sub-tidal soft sediment dwelling macro-invertebrates of Konkan, west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Vizakat, L.; Harkantra, S.N.; Parulekar, A.H.

    (Shannon Wiener index) varied from 0.44 to 3.58 (X = 1.94, SD = + or - 0.89). Population and community structure were more stable in premonsoon months. Carnivorous species Glycera alba modified the community structure mainly due to prey...

  7. EST Table: BY928766 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available ori] 10/08/29 59 %/194 aa FBpp0080116|CAH1-PA 10/08/28 37 %/126 aa R01E6.3a#CE294...33#WBGene00000282#locus:cah-4#carbonic anhydrase#status:Confirmed#UniProt:Q21614#protein_id:CAA 92190.2 10/0

  8. KITAE I: Edge Organisation in Battlespace Helmand (United States)


    Politica , 2004. 6 Optimality Historically the RCT assumption of optimality has been Mitchell, William. (2004) Instrumental Friend or Foe? Constructivist Activism in Security Policy Means Analysis. Politica

  9. InterProScan Result: FS789827 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS789827 FS789827_3_ORF1 471A90174D851C20 PANTHER PTHR23300 SELENIUM-BINDING PROTEIN 9e-194 T IPR008826 Sele...nium-binding protein Molecular Function: selenium binding (GO:0008430) ...

  10. Daytime Sleep Patterns in Preschool Children with Autism, Developmental Delay, and Typical Development (United States)

    Schwichtenberg, A. J.; Iosif, Ana-Maria; Goodlin-Jones, Beth; Tang, Karen; Anders, Thomas


    The present study examined daytime sleep patterns in 3 groups of preschool-aged children: children with autism, children with developmental delay, and children who were developing typically. Sleep was assessed in 194 children via actigraphy and parent-report sleep diaries for 7 consecutive days on 3 separate occasions over 6 months. Children with…

  11. Intergenerational Contact and Mediators Impact Ambivalence towards Future Selves (United States)

    Jarrott, Shannon E.; Savla, Jyoti


    Intergenerational contact can promote positive attitudes towards elders. However, contact with older adults often fosters multiple stereotypes, which may contribute to ambivalence about aging and poorer health in late life. Online survey data from 457 young adults (M age = 19.4 years; 74% female) were used to explore the relationship between…

  12. Study of Locomotor Disability due to Various Types of Trauma

    Directory of Open Access Journals (Sweden)

    Sandip Rameshrao Dhole


    Conclusion: Trauma contributes not only to significant number of disabilities, but also to severity of disability. Road traffic accidents and railway accidents are major causes of traumatic locomotor disability and young persons are the usual victims of such disasters. [Natl J Med Res 2015; 5(3.000: 194-198

  13. Distribution of total radiation widths for neutron resonances of Pt isotopes

    Directory of Open Access Journals (Sweden)

    Koehler P.E.


    Full Text Available High quality neutron capture and transmission data were measured on isotopically enriched 192,194,195,196Pt and natural Pt samples at ORELA. R-matrix analysis of this data revealed resonance parameters for 159, 413, 423, 258, and 11 neutron resonances for neutron energies below 5.0, 16.0, 7.5, 16.0, and 5.0 keV for 192,194,195,196,198Pt+n, respectively. Earlier analysis of data on reduced neutron widths, Γ0n, showed that the distributions of Γ0n for 192,194Pt deviate significantly from the Porter-Thomas distribution (PTD predicted by random matrix theory. In this contribution we report on preliminary results of the analysis of distribution of total radiation widths, Γγ, in 192,194,195,196Pt+n reactions. Comparison of experimental data with predictions made within the nuclear statistical model indicates that standard models of Photon Strength Functions (PSFs and Nuclear Level Density predict Γγ distributions which are too narrow. We found that satisfactory agreement between experimental and simulated distributions can be obtained only by a strong suppression of the PSFs at low γ-ray energies and/or by violation of the usual assumption that primary transitions from neutron resonances follow the PTD. The shape of PSFs needed for reproduction of our Γγ data also nicely reproduces spectra from several (n,γ experiments on the neighbor nuclide 198Au.

  14. NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist (United States)

    Dammermann, Werner; Zhang, Bo; Nebel, Merle; Cordiglieri, Chiara; Odoardi, Francesca; Kirchberger, Tanja; Kawakami, Naoto; Dowden, James; Schmid, Frederike; Dornmair, Klaus; Hohenegger, Martin; Flügel, Alexander; Guse, Andreas H.; Potter, Barry V. L.


    The nucleotide NAADP was recently discovered as a second messenger involved in the initiation and propagation of Ca2+ signaling in lymphoma T cells, but its impact on primary T cell function is still unknown. An optimized, synthetic, small molecule inhibitor of NAADP action, termed BZ194, was designed and synthesized. BZ194 neither interfered with Ca2+ mobilization by d-myo-inositol 1,4,5-trisphosphate or cyclic ADP-ribose nor with capacitative Ca2+ entry. BZ194 specifically and effectively blocked NAADP-stimulated [3H]ryanodine binding to the purified type 1 ryanodine receptor. Further, in intact T cells, Ca2+ mobilization evoked by NAADP or by formation of the immunological synapse between primary effector T cells and astrocytes was inhibited by BZ194. Downstream events of Ca2+ mobilization, such as nuclear translocation of “nuclear factor of activated T cells” (NFAT), T cell receptor-driven interleukin-2 production, and proliferation in antigen-experienced CD4+ effector T cells, were attenuated by the NAADP antagonist. Taken together, specific inhibition of the NAADP signaling pathway constitutes a way to specifically and effectively modulate T-cell activation and has potential in the therapy of autoimmune diseases. PMID:19541638

  15. Austria uuringu tõlgendus: Eesti on eurotsooni must majandus / Kaja Koovit ; kommenteerinud Maria Alajõe

    Index Scriptorium Estoniae

    Koovit, Kaja, 1968-


    Austrias asuva Linzi ülikooli uuringu kohaselt moodustab varimajandus Eesti majandusest kolmandiku. SSE Riga ehk Stockholmi majanduskooli Riias Balti varimajanduse uuringu põhjal võib varimajanduse osakaal Eestis olla 19,4 protsenti. Varimajanduse alal maailma juhtivaks eksperdiks peetava Friedrich Schneideri uuringust. Marje Josingu ja Juhan Partsi hinnanguid. Tabel: Varimajandus

  16. Hollow-Core Fiber Lamp (United States)

    Yi, Lin (Inventor); Tjoelker, Robert L. (Inventor); Burt, Eric A. (Inventor); Huang, Shouhua (Inventor)


    Hollow-core capillary discharge lamps on the millimeter or sub-millimeter scale are provided. The hollow-core capillary discharge lamps achieve an increased light intensity ratio between 194 millimeters (useful) and 254 millimeters (useless) light than conventional lamps. The capillary discharge lamps may include a cone to increase light output. Hollow-core photonic crystal fiber (HCPCF) may also be used.

  17. Aggression in Dating Relationships Compared by Country of Origin (United States)

    Seligowski, Antonia; West, Doe


    Aims: The purpose of this study was to analyze prevalence levels of aggression in dating relationships and to compare this by country of origin. The study also seeks more understanding of the violence experienced by men in these countries. Method: A convenience sample was used; study participants were 194 females and 168 males ranging in age from…

  18. AcEST: DK957319 [AcEST

    Lifescience Database Archive (English)


  19. Attitudes and Self-Efficacy of Pre-Service Teachers towards Inclusion in Pakistan (United States)

    Sharma, Umesh; Shaukat, Sadia; Furlonger, Brett


    This study sought to determine the attitudes and teaching self-efficacy of pre-service teachers towards the inclusion of students with disabilities into regular classrooms. A questionnaire was administered to 194 pre-service Pakistani teachers (male 73, female 121) enrolled in a 1-year teacher education programme at a government university in…

  20. KM Critical Success Factors: A Comparison of Perceived Importance Versus Implementation in Malaysian ICT Companies (United States)

    Chong, Siong Choy


    Purpose: This research examines the level of perception and implementation of 11 identified knowledge management (KM) success factors and their differences among the information and communication technology (ICT) companies operating in Malaysia. Design/methodology/approach: The survey data was obtained from a study of 427 middle managers from 194

  1. How Providing Mentoring Relates to Career Success and Organizational Commitment: A Study in the General Managerial Population (United States)

    Bozionelos, Nikos; Bozionelos, Giorgos; Kostopoulos, Konstantinos; Polychroniou, Panagiotis


    Purpose: This study aims to investigate the relationship of mentoring provided with career success and organizational commitment in the general managerial population. Design/methodology/approach: Participants were 194 native British who were employed in a variety of jobs, professions and industries in the United Kingdom. Findings: Mentoring…

  2. The Migration and Remittances Factbook 2008


    World Bank


    This fact book for 2008 attempts to present numbers and facts behind the stories of international migration and remittances, drawing on authoritative, publicly available data. It provides a snapshot of statistics on immigration, emigration, skilled emigration, and remittance flows for 194 countries and 13 regional and income groups. The top migrant destination countries are the United Stat...

  3. Communist Exploitation of Nationalism in Brazil (United States)


    the crowd and prolonged cheers at his closing phrases: "We are all Brazilians.’" (Somos todos Brasileiros) , "Long live Brazil."’ (Viva o Brasil ...Jornal do Comercio , 6 Jan. 1952, p. 3. 30FBIS No. 51, 12 Mar. 1952, ZYC9 Rio de Janeiro, 12 Mar. 1952. 31FBIS No. 194, 5 Oct. 1953, PRL7 Rio de

  4. Natural Resources Research Program. Annotated Bibliography for Regional Recreation Demand Models (United States)


    183-194. Greenley , Douglass A., Walsh, Richard G., and Young, Robert A. 1981. "Option Value: Empirical Evidence from a Case Study of Recreation and...tests were actually conducted. 58. Greenley , Douglass A., Walsh, Richard G., and Young, Robert A. 1981. "Option Value: Empirical Evidence from a Case

  5. Gclust Server: 17075 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 17075 Cch_Cag_1623 Cluster Sequences Related Sequences(20) 194 hypothetical protein... 6 1.00e-35 0.0 0.0 0.0 20.0 3.23 0.0 Show 17075 Cluster ID 17075 Sequence ID Cch_Cag_1623 Link to cluster s

  6. Data of evolutionary structure change: 1YLJA-3BLMA [Confc[Archive

    Lifescience Database Archive (English)


  7. Construct Validity of the Offer Self-Image Questionnaire and Its Relationship with Self-Esteem, Depression, and Ego Development (United States)

    Lindfors, Kaj; Elovainio, Marko; Sinkkonen, Jari; Aalberg, Veikko; Vuorinen, Risto


    Construct validity of the Offer Self-Image Questionnaire (OSIQ) was studied in a sample of 194 normal Finnish adolescents from 14 to 16 years of age. Confirmatory factor analysis provided support for the hierarchical structure of adolescents' self-image with 5 lower-order factors loading on a single higher-order factor. Lower-order factors were…

  8. Initial screening of chili and sweet pepper germplasm for resistance to chili thrips, Scirtothrips dorsalis Hood. (United States)

    A preliminary evaluation for resistance to chili thrips, Scirtothrips dorsalis Hood of 41 and 194 pepper (Capsicum annuum L.) germplasms during 1987 and 1988, espectively, indicated chili accessions may be a promising source of resistance . In contrast, all sweet pepper accessions tested were highly...

  9. The quasi-continuum of gamma rays following the decay of superdeformed bands in the Hg region

    Energy Technology Data Exchange (ETDEWEB)

    Lauritsen, T.; Khoo, T.L.; Janssens, R.V.F. [Argonne National Lab., IL (United States)] [and others


    The quasi-continuum part of the spectrum associated with the decay-out of the yrast superdeformed band in {sup 194}Hg has been extracted. It has for the first time been possible to compare the spin and excitation energy determined from the analysis of the quasi-continuum {gamma} rays to the exact result obtained from the one-step linking transitions.

  10. Experiment list: SRX186620 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ediates cooperative binding betweenRFX and NF-Y. RFX binds the X1 box of MHC-II promoters || antibody vendorname=Rockland Immunochemi...cals || antibody vendorid=200-401-194 || control=IgG-rab || control description=Inp

  11. Development of an Abbreviated Social Phobia and Anxiety Inventory (SPAI) Using Item Response Theory: The SPAI-23 (United States)

    Roberson-Nay, Roxann; Strong, David R.; Nay, William T.; Beidel, Deborah C.; Turner, Samuel M.


    An abbreviated version of the Social Phobia and Anxiety Inventory (SPAI) was developed using methods based in nonparametric item response theory. Participants included a nonclinical sample of 1,482 undergraduates (52% female, mean age = 19.4 years) as well as a clinical sample of 105 individuals (56% female, mean age = 36.4 years) diagnosed with…

  12. Trækonstruktioner

    DEFF Research Database (Denmark)

    Larsen, H.J.; Riberholt, H.

    Denne anvisning behandler materialer til trækonstruktioner og beregning af sædvanlige elementer og konstruktioner i henhold til Trænormen fra 2003 med tillæg. Forbindelser behandles i SBI-anvisning 194: Trækonstruktioner. Forbindelser. Anvisningen er tænkt anvendt af projekterende og som lærebog ...

  13. Compatibility Standards and the Market for Telecommunications Services (United States)


    1984. Nesmith, A., "A Long, Arduous March Toward Standardization," Smithsonian, March 1985, 176-194. Olson , Mancur , The Logic of Collective Action...small." See Olson (1965) for a discussion of this issue. Olson discusses, among other examples, the case of international alliances in which large

  14. The Inverse Source Problem for Maxwell’s Equations (United States)


    of applied biomedical engineering and also as a mathematical problem (see for example [3, 22, 15, 7, 14, 9, 6, 121 where we have emphasized...BLEISTEIN AND J. COHEN, Nonuniqueness in the inverse source problem in acoustics and electromagnetics, Journal of Mathematical Physics, 18 (1977), pp. 194

  15. Body height and arterial pressure in seated and supine young males during +2 G centrifugation

    DEFF Research Database (Denmark)

    Arvedsen, Sine K.; Eiken, Ola; Kölegård, Roger;


    by the use of a human centrifuge would increase mean arterial pressure (MAP) more in tall than in short males in the seated position. In short (162-171cm, n=8) and tall (194-203cm, n=10) healthy males (18-41yr), brachial arterial pressure, heart rate (HR) and cardiac output were measured during +2G...

  16. Perceptions of Turkish Pre-Service Science Teachers Concerning Constructivist Perspectives to Teach (United States)

    Taskin-Can, Bilge


    The purpose of this study is to identify how a four-semester sequence teacher education program helps change pre-service teachers' perceptions about constructivist teaching and learning as they progress through the program. The participants of the study included a total of 194 science pre-service teachers in four different semesters of their…

  17. Structural Impediments to African Growth? New Evidence from British African Real Wages, 1880-1965

    NARCIS (Netherlands)

    Frankema, E.H.P.; Waijenburg, van M.


    British colonial rule has often been praised for its comparatively benign features, such as its support of local educational development. This study argues that the impact of British educational policies and investments on the supply of schooling in British Africa should not be overstated. Until 194

  18. Development of High-Activity Para- to Ortho-Hydrogen Conversion Catalysts. Volume 2 (United States)


    deuterium with glass surfaces.. G. S. Annis ,* H. Clough, and D. 0. Eley. Trans. Faraday Soc. 54, 194-9,(1958). C.A. 52, 17860 d. D. E. G. Austen, D. J. E...Iowa Lab., Iowa, USA, Proc. Midwest 4onf. Theoret. Phys.; Notredame Ind.; (63); p. 295-7; in Eng. Ortho- and paratritium. E. W. Albers , P. Harteck, and R

  19. 78 FR 66258 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Airplanes (United States)


    ...-194-AD; Amendment 39-17650; AD 2013-22-18] RIN 2120-AA64 Airworthiness Directives; Empresa Brasileira... directive (AD) for certain Empresa Brasileira de Aeronautica S.A. (EMBRAER) Model EMB-135ER, - 135KE, -135KL... information identified in this AD, contact Empresa Brasileira de Aeronautica S.A. (EMBRAER),...

  20. Cultural Resource Investigations within the U.S. Army Corps of Engineers New Orleans to Venice Hurricane Protection Project (United States)


    Louisiana State University, New Orleans. Ries, Maurice 1936 The Mississippi Fort Called Fort de la Boulaye. t,’uisiani _Historical Ouarterly 19(4...notebooks, tim, etc. (4) " ravel --to research area, i,terval while at site, etc . (5) Computer and other data- ,rc,:’essing facilities. (6) Miscellaneous data

  1. Use of the GMFCS in infants with CP : the need for reclassification at age 2 years or older

    NARCIS (Netherlands)

    Gorter, Jan Willem; Ketelaar, Marjolijn; Rosenbaum, Peter; Helders, Paul J. M.; Palisano, Robert


    The stability of the Gross Motor Function Classification System (GMFCS) over time is described in 77 infants (41 boys, 36 girls) with cerebral palsy (CP; mean age 19.4mo [SD 1.6 mo]; 27 unilateral spastic, 42 bilateral spastic, eight dyskinetic type) and in the same children at follow-up at age 2 to

  2. Gclust Server: 194123 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 194123 Ctep_CT0791 Cluster Sequences - 145 hypothetical protein 1 1.00e-80 0.0 0.0 0.0 6.67 0.0 0.0 Show 194...123 Cluster ID 194123 Sequence ID Ctep_CT0791 Link to cluster sequences Cluster Seq

  3. Gclust Server: 194136 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available 194136 Ctep_CT0811 Cluster Sequences - 145 hypothetical protein 1 1.00e-70 0.0 0.0 0.0 6.67 0.0 0.0 Show 194...136 Cluster ID 194136 Sequence ID Ctep_CT0811 Link to cluster sequences Cluster Seq

  4. The Code of Conduct at 42: Time for a Middle-Age Check-Up (United States)


    surroundings starkly different from those the POW had just left, 149 coupled with offers of cigarettes, chocolate , or a walk to a beer garden.150 The...emphasized victory at any cost, 194 and the Meiji Code which treated every order of a superior as coming from the emperor himself. The ultimate

  5. Radiation Measurement for Ji Nan MNSR Decommissioning

    Institute of Scientific and Technical Information of China (English)


    Ji'Nan MNSR is an under moderated reactor of pool-tank type, UAl with high-enriched 235U as fuel, beryllium as reflector, and light water as coolant. It was built in 1989, and shutdown in 2008. It operated 840 times, the total operation time is 3 194.

  6. EST Table: CK564164 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK564164 rswpb0_007585.y1 10/09/29 100 %/194 aa ref|NP_001040339.1| GTP binding pro...nfirmed#UniProt:P91917#protein_id:CAB07131 .1 10/09/10 79 %/193 aa AGAP000672-PB Protein|X:118564

  7. AcEST: BP916079 [AcEST

    Lifescience Database Archive (English)

    Full Text Available S=Oryza... 34 4.1 tr|Q2KKR3|Q2KKR3_SINCH Schwannoma-associated protein-like protei... 33 9.1 tr|Q54HT9|Q54HT... 156 LNQSAEHQSVEPHCDEIEYLCNQCMSMWVLMMKVCTLIW 194 >tr|Q2KKR3|Q2KKR3_SINCH Schwannoma-associated protein-like

  8. Dicty_cDB: SFJ208 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available _1( AF454831 |pid:none) Apriona germari cathepsin D mRNA, ... 181 2e-90 AB078420_...D-like... 194 3e-97 EF000001_1( EF000001 |pid:none) Fasciola hepatica cathepsin D-like... 188 7e-95 AF454831

  9. The Background to Current Theories of Scuffing (United States)


    but was in fact an oleophobic monolayer of adsorbed polar molecules. The dipper was replaced and the temperature of the solution increased until...182A (1943), 12. BIGELOW, W.C., GLASS, E., ZIZMAN, W.A. Oleophobic Monolayers II, J, Colloid Soc, 1, No.6 (194?). 13. ASKWITH, T.C., CROUCH, R.F

  10. VizieR Online Data Catalog: Phoenix dwarf galaxy RV and [Fe/H] catalog (Kacharov+, 2017) (United States)

    Kacharov, N.; Battaglia, G.; Rejkuba, M.; Cole, A. A.; Carrera, R.; Fraternali, F.; Wilkinson, M. I.; Gallart, C. G.; Irwin, M.; Tolstoy, E.


    This catalogue provides photometry, radial velocities, metallicities, and the Ca triplet (CaT) equivalent widths of 228 stars in the field of the Phoenix dwarf galaxy observed with the FORS2 spectrograph at the VLT. 194 stars are confirmed Phoenix members. (1 data file).

  11. Patterns of Commitment to Work and Parenting: Implications for Role Strain. (United States)

    O'Neil, Robin; Greenberger, Ellen


    Examined relations between patterns of commitment to work and parenting and role strain among 102 middle-class fathers and 194 mothers. For fathers of preschoolers in dual-earner marriages, pattern of low work-high parental commitment was associated with least role strain. Relations between commitment patterns and role strain were conditioned by…

  12. The Orchestra as a Laboratory

    DEFF Research Database (Denmark)

    Paunova, Minna; Velikova, Silviya Svejenova

    Symphonic orchestras—“a mélange of musicians, volunteers, and paid staff whose contributions must be closely coordinated” (Allmendinger, Hackman, & Lehman, 1996: 194)—have been of growing interest for scholars of organization for their creative and collaborative performance through projects...

  13. Effect of the XRCC1 and XRCC3 Genetic Polymorphisms on the Efficacy of Platinum-based Chemotherapy in Patients with Advanced Non-small Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Chong’an XU


    Full Text Available Background and objective DNA repair gene polymorphisms can be used to predict the sensitivity of platinum-based chemotherapy. Thus, such polymorphisms are important for the individual treatment of non-small cell lung cancer (NSCLC. The aim of this study is to investigate the relationship between X-ray repair cross complementing protein 1 (XRCC1 and X-ray repair cross complementing protein 3 (XRCC3 gene polymorphisms and the chemosensitivity of platinum-based chemotherapy in patients with advanced NSCLC. Methods Genomic DNA were extracted from the sera of a total of 130 patients with advanced NSCLC who received platinum-based chemotherapy. XRCC1 Arg194 Trp, Arg399 Gln, and XRCC3 Thr241 Met were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method, and the relationship between XRCC1 and XRCC3 polymorphisms and chemotherapy sensitivity was analyzed. Results A total of 130 patients with advanced NSCLC received platinum-based chemotherapy, with an overall response rate of 33.8% after two chemotherapy cycles. The XRCC1 194 and 399 genetic polymorphisms, but not XRCC3 241, were found to be related to the chemosensitivity. The objective response rate of the patients with at least one XRCC1 194 Trp allele was 2.5 times higher than that of Arg/Arg genotype carriers (42.1% vs 22.2%, OR=2.545, 95%CI: 1.159-5.590, P=0.020. The objective response rate of the XRCC1 399 Arg/Arg genotype carriers was significantly higher than that of the patients with at least one Gln allele (45.5% vs 21.9%, OR=0.336, 95%CI: 0.156-0.722, P=0.005. Combined effects between XRCC1 194 and XRCC1 399 were observed. The objective response rate of the patients with at least one XRCC1 194 Trp allele and a 399 Arg/Arg genotype was significantly higher than that of patients with 194 Arg/Arg and 399 Arg/Gln genotypes (44.4% vs 18.8%, OR=3.467, 95%CI: 1.223-9.782, P=0.019. Moreover, XRCC1 and XRCC3 have a combined effect in predicting chemosensitivity

  14. Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system. (United States)

    Schmidt, Hayden R; Radić, Zoran; Taylor, Palmer; Fradinger, Erica A


    The zebrafish is rapidly becoming an important model system for screening of new therapeutics. Here we evaluated the zebrafish as a potential pharmacological model for screening novel oxime antidotes to organophosphate (OP)-inhibited acetylcholinesterase (AChE). The ki values determined for chlorpyrifos oxon (CPO) and dichlorvos (DDVP) showed that CPO was a more potent inhibitor of both human and zebrafish AChE, but overall zebrafish AChE was less sensitive to OP inhibition. In contrast, aldoxime antidotes, the quaternary ammonium 2-PAM and tertiary amine RS-194B, showed generally similar overall reactivation kinetics, kr, in both zebrafish and human AChE. However, differences between the Kox and k2 constants suggest that zebrafish AChE associates more tightly with oximes, but has a slower maximal reactivation rate than human AChE. Homology modeling suggests that these kinetic differences result from divergences in the amino acids lining the entrance to the active site gorge. Although 2-PAM had the more favorable in vitro reactivation kinetics, RS-194B was more effective antidote in vivo. In intact zebrafish embryos, antidotal treatment with RS-194B rescued embryos from OP toxicity, whereas 2-PAM had no effect. Dechorionation of the embryos prior to antidotal treatment allowed both 2-PAM and RS-194B to rescue zebrafish embryos from OP toxicity. Interestingly, RS-194B and 2-PAM alone increased cholinergic motor activity in dechorionated embryos possibly due to the reversible inhibition kinetics, Ki and αKi, of the oximes. Together these results demonstrate that the zebrafish at various developmental stages provides an excellent model for investigating membrane penetrant antidotes to OP exposure.

  15. Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases. (United States)

    Radić, Zoran; Sit, Rakesh K; Kovarik, Zrinka; Berend, Suzana; Garcia, Edzna; Zhang, Limin; Amitai, Gabriel; Green, Carol; Radić, Bozica; Fokin, Valery V; Sharpless, K Barry; Taylor, Palmer


    We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS. Starting with the initial lead oxime RS41A identified in our earlier study and extending to the azepine analog RS194B, reactivation rates for OP-hAChE conjugates formed by sarin, cyclosarin, VX, paraoxon, and tabun are enhanced severalfold in vitro. To analyze the mechanism of intrinsic reactivation of the OP-AChE conjugate and penetration of the blood-brain barrier, the pH dependence of the oxime and amine ionizing groups of the compounds and their nucleophilic potential were examined by UV-visible spectroscopy, (1)H NMR, and oximolysis rates for acetylthiocholine and phosphoester hydrolysis. Oximolysis rates were compared in solution and on AChE conjugates and analyzed in terms of the ionization states for reactivation of the OP-conjugated AChE. In addition, toxicity and pharmacokinetic studies in mice show significantly improved CNS penetration and retention for RS194B when compared with RS41A. The enhanced intrinsic reactivity against the OP-AChE target combined with favorable pharmacokinetic properties resulted in great improvement of antidotal properties of RS194B compared with RS41A and the standard peripherally active oxime, 2-pyridinealdoxime methiodide. Improvement was particularly noticeable when pretreatment of mice with RS194B before OP exposure was combined with RS194B reactivation therapy after the OP insult.

  16. Construction and characterization of double mutants in nitrogenase of Klebsiella pneumoniae

    Institute of Scientific and Technical Information of China (English)

    ZHAO Dehua; LI Jilun


    Two mutants in nitrogenase of Klebsiella pneumoniae are constructed by site-directed mutagenesis and gene replacement procedure, which express the nitrogenases with Lysine and Glutamine substituting for α-Glutamine 190and α-Histidine 194 respectively (Kp-Q α190 K and Kp-H α194 Q). The above two substitutions are respectively introduced into a nifV mutant (expressing a citrate-containing nitrogenase) and sequentially two double mutants are obtained (Kp-Q α190 K-nifV- and Kp-H α194 Q-nifV-). All four mutants exhibit strict Nif- phenotype under the N2-fixation condition and fail to grow diazotrophically. Altered nitrogneases are effeetively depressed and the C2H2 reduction analysis shows that the double substitutions in Kp-Q α190K-nifV abolish cell C2H2 reduction activity, but Kp-H α194Q-nifV cells maintain a C2H2 reduction activity at 10% of that of wild type. Whole cell C2D2 reduction by all four mutants in comparison to the wild type and nifV mutant is also detected. The results show that only single α-Gln194 substitution does not perturb the stereospecificity of protonation of C2D2. These results indicate that the α- Glutamine 190 and its combination with homocitrate are essential to the catalytic activity of nitrogenase and it is proposed that α-Glutamine 190 and its combination with homocitrate are involved in the proton and/or electron transfer to FeMoco. The nitrogenases from these double mutants will be useful in further analysis of the entry of the proton and/or electron to FeMoco and the substrate binding sites.

  17. Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Márcia Cristina Duarte; Jucimara Colombo; Andrea Regina Baptista Rossit; Alaor Caetano; Aldenis Albaneze Borim; Durval Wornrath; Ana Elizabete Silva


    AIM: To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population.METHODS: Genotyping by PCR-RFLP was carried out on 202 patients with chronic gastritis (CG) and 160 patients with gastric cancer (GC), matched to 202 (C1) and 150(C2) controls, respectively.RESULTS: No differences were observed among the studied grou ps with regard to the genotype distribution of XRCC1 codons 194 and 399 and of XRCC3 codon 241. However, the combined analyses of the three variant alleles (194Trp, 399Gln and 241Met) showed an increased risk for chronic gastritis when compared to the GC group. Moreover, an interaction between the polymorphic alleles and demographic and environmental factors was observed in the CG and GC groups. XRCC1 194Trp was associated with smoking in the CG group,while the variant alleles XRCC1 399Gln and XRCC3241Met were related with gender, smoking, drinking and H pylori infection in the CG and GC groups.CONCLUSION: Our results showed no evidence of a rela-tionship between the polymorphisms XRCC1Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk of chronic gastritis and gastric cancer in the Brazilian population, but the combined effect of these variants may interact to increase the risk for chronic gastritis,considered a premalignant lesion. Our data also indicate a gene-environment interaction in the susceptibility to chronic gastritis and gastric cancer.

  18. Immuno-vectorization of radioelements emitters of alpha particles: a new therapy in cancerology; Immunovectorisation de radioelements emetteurs de particules alpha: une nouvelle voie therapeutique en cancerologie

    Energy Technology Data Exchange (ETDEWEB)

    Bourgeois, M


    The radio-immunotherapy is an anti cancerous therapy which consists in vectorising with immuno-specific agents very radio toxic radioelements on tumors or in their environment to destroy them. The first part of this report presents the different characteristics of antibodies as well as their means of production under monoclonal shapes specifically steered against a tumoral antigen of interest. The second part of this report replaces the importance of the immunological vectors in the context of the nuclear medicine. It is notably described that the different methods which allow to radio-label the vector, as well as the different ways of optimization which were envisaged to improve the targeting of radioelements on a tumor. These different developments allow to define the potential place of the alpha radio-immunotherapy in treatments and so re-place the interest of the experimental part. If the radio-immunotherapy, using beta emitters isotopes as the {sup 131}iodine or the{sup 90}yttrium, is today current in anti cancerous therapy, it finds limits because of the disintegration characteristics of the isotopes it uses. Indeed, compared with alpha particles, the beta particles deposit less energy by unit of length in the crossed material.The experimental part of this report aims at studying the feasibility of the coupling between an immunological vector and an alpha emitter isotope.The different tests led on the bismuth 213, the bismuth 212, the lead 212 and the astatine 211 demonstrated that the fixation of these radionuclides was possible. This research theme is strengthened by the construction in Nantes of a cyclotron with high energy ( A.R.R.O.N.A.X.) and the optimization of the obtained promising results should allow a therapeutic use in oncology of the alpha radio-immunotherapy. (N.C.)

  19. Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge. (United States)

    Sholukh, Anton M; Watkins, Jennifer D; Vyas, Hemant K; Gupta, Sandeep; Lakhashe, Samir K; Thorat, Swati; Zhou, Mingkui; Hemashettar, Girish; Bachler, Barbara C; Forthal, Donald N; Villinger, Francois; Sattentau, Quentin J; Weiss, Robin A; Agatic, Gloria; Corti, Davide; Lanzavecchia, Antonio; Heeney, Jonathan L; Ruprecht, Ruth M


    Although IgA is the most abundantly produced immunoglobulin in humans, its role in preventing HIV-1 acquisition, which occurs mostly via mucosal routes, remains unclear. In our passive mucosal immunizations of rhesus macaques (RMs), the anti-HIV-1 neutralizing monoclonal antibody (nmAb) HGN194, given either as dimeric IgA1 (dIgA1) or dIgA2 intrarectally (i.r.), protected 83% or 17% of the RMs against i.r. simian-human immunodeficiency virus (SHIV) challenge, respectively. Data from the RV144 trial implied that vaccine-induced plasma IgA counteracted the protective effector mechanisms of IgG1 with the same epitope specificity. We thus hypothesized that mucosal dIgA2 might diminish the protection provided by IgG1 mAbs targeting the same epitope. To test our hypothesis, we administered HGN194 IgG1 intravenously (i.v.) either alone or combined with i.r. HGN194 dIgA2. We enrolled SHIV-exposed, persistently aviremic RMs protected by previously administered nmAbs; RM anti-human IgG responses were undetectable. However, low-level SIV Gag-specific proliferative T-cell responses were found. These animals resemble HIV-exposed, uninfected humans, in which local and systemic cellular immune responses have been observed. HGN194 IgG1 and dIgA2 used alone and the combination of the two neutralized the challenge virus equally well in vitro. All RMs given only i.v. HGN194 IgG1 became infected. In contrast, all RMs given HGN194 IgG1+dIgA2 were completely protected against high-dose i.r. SHIV-1157ipEL-p challenge. These data imply that combining suboptimal defenses at the mucosal and systemic levels can completely prevent virus acquisition. Consequently, active vaccination should focus on defense-in-depth, a strategy that seeks to build up defensive fall-back positions well behind the fortified frontline.

  20. 溶剂法回收废旧聚酯纺织品技术%Recovery of waste polyester textiles via solvent method

    Institute of Scientific and Technical Information of China (English)

    石娜; 武志云; 汪少朋; 甘胜华


    Polyester (PET) and polyester/cotton fabrics were dissolved by dimethyl sulfoxide (DMSO) for recycled use. The results show that polyester fabric can be dissolved easily in DMSO for recovery, especially at 185 - 194 ℃ , faster dissolving is observed and dissolving can be completed within 12 minutes. Meanwhile, within certain length of time DMSO dissolves polyester but cotton fibers. Therefore, for separating and recovering, put polyester /cotton fabrics into the DMSO reagent, dissolve them at 185 - 194 ℃ for 60 minutes, then recover the cotton fibers by filtering and recover polyester from the solution at around 185 - 194 ℃. The recycled cotton fibers exhibit stable properties and find wide spectrum of applications. The intrinsic viscosity of regenerated PET increased with the increase of recovery percentage of DMSO.%利用二甲基亚砜(DMSO)溶解纯涤纶织物及涤/棉混纺织物,回收利用涤纶(PET)和棉纤维.结果表明,DMSO试剂可以回收纯涤纶织物,尤其当温度在185~194℃时DMSO与纯涤纶织物溶解反应相对较快,溶解时间为12 min.在一定反应时间内DMSO易溶解涤纶而不溶解棉纤维,可将其用于回收聚酯和棉纤维.涤/棉织物投入到温度为185~194℃的DMSO试剂中,溶解60 min,可将不溶于DMSO试剂的棉纤维在温度为185~194℃的条件下滤出并回收,同时从溶解液中回收聚酯.回收的棉纤维性能稳定,运用领域广泛.再生聚酯的特性黏度随DMSO试剂回收率的增加而增大.

  1. Dose and polymorphic genes xrcc1, xrcc3, gst play a role in the risk of articledeveloping erythema in breast cancer patients following single shot partial breast irradiation after conservative surgery

    Directory of Open Access Journals (Sweden)

    Muti Paola


    Full Text Available Abstract Background To evaluate the association between polymorphisms involved in DNA repair and oxidative stress genes and mean dose to whole breast on acute skin reactions (erythema in breast cancer (BC patients following single shot partial breast irradiation (SSPBI after breast conservative surgery. Materials and Methods Acute toxicity was assessed using vers.3 criteria. single nucleotides polymorphisms(SNPs in genes: XRCC1(Arg399Gln/Arg194Trp, XRCC3 (A4541G-5'UTR/Thr241Met, GSTP1(Ile105Val, GSTA1 and RAD51(untranslated region. SNPs were determined in 57 BC patients by the Pyrosequencing analysis. Univariate(ORs and 95% CI and logistic multivariate analyses (MVA were performed to correlate polymorphic genes with the risk of developing acute skin reactions to radiotherapy. Results After SSPBI on the tumour bed following conservative surgery, grade 1 or 2 acute erythema was observed in 19 pts(33%. Univariate analysis indicated a higher significant risk of developing erythema in patients with polymorphic variant wt XRCC1Arg194Trp, mut/het XRCC3Thr241Met, wt/het XRCC3A4541G-5'UTR. Similarly a higher erythema rate was also found in the presence of mut/het of XRCC1Arg194Trp or wt of GSTA1. Whereas, a lower erythema rate was observed in patients with mut/het of XRCC1Arg194Trp or wt of XRCC1Arg399Gln. The mean dose to whole breast(p = 0.002, the presence of either mut/het XRCC1Arg194Trp or wt XRCC3Thr241Met (p = 0.006 and the presence of either mut/het XRCC1Arg194Trp or wt GSTA1(p = 0.031 were confirmed as predictors of radiotherapy-induced erythema by MVA. Conclusions The Whole breast mean dose together with the presence of some polymorphic genes involved in DNA repair or oxidative stress could explain the erythema observed after SSPBI, but further studies are needed to confirm these results in a larger cohort. Trial Registration Identifier: NCT01316328

  2. Genetic parameters of the piglet mortality traits stillborn, weak at birth, starvation, crushing, and miscellaneous in crossbred pigs

    DEFF Research Database (Denmark)

    Strange, T.; Ask, B.; Nielsen, B.


    This study aimed to estimate genetic parameters for the mortality causes stillborn, weak at birth, starvation, crushing, and miscellaneous in crossbred piglets produced by crossbred dams. Data were collected in a single Danish commercial herd from October 2006 to July 2008 and consisted of 34......,194 piglets (2,152 litters), which originated from 195 Danish Duroc sires and 955 crossbreds between Danish Landrace and Danish Yorkshire dams. Of the 34,194 piglets born, 11.5% were stillborn, 4.2% were crushed by the sow, 2.7% died due to starvation, 2.3% were weak at birth, and 2.2% died of miscellaneous...... causes before weaning. The first 4 mentioned causes were analyzed multivariately using a generalized linear mixed model with a probit link function, including the genetic effect of both sire and dam. Heritabilities based on the sire component ranged between 0.08 for stillborn and 0.21 for starvation...

  3. Sporopollen and algae research of core B106 in the northern South China Sea and its paleoenvironmental evolution

    Institute of Scientific and Technical Information of China (English)


    Based on the high-resolution sporopollen and algae research of the sediments from core B106 in the northem South China Sea,three sporopollen assemblage zones have been distinguished in ascending order:Zone 1 (294-194 cm):pinus-Quercus (evergreen)-Gramineae-Polypodia-ceae- Pterdium-Dicranopteris.Zone 2 (194-94 cm):Pinus-Quercus (evergreen)-Polypodiaceae-Pteridium- Dicranopteris.Zone 3 (94-4 cm):Pinus-Polypodiaceae-Pteridium-Quercus(evergreen)-Dicranopteris.The three sporopollen zones correspond to three stages of vegetation,climate and paleoenvironment evolution of the northern part of the South China Sea since 11 000 years ago.Combined with AMS 14C dating,the sporopollen and algae data can be a scientific basis for stratigraphic division and reconstruction of paleoclimate and paleoenvironment in the South China Sea.

  4. Dicty_cDB: FC-IC1321 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC-IC (Link to library) FC-IC1321 (Link to dictyBase) - - - Contig-U15335-1 FC-IC13... (Link to library) Clone ID FC-IC1321 (Link to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link t...o Contig Contig-U15335-1 Original site URL %: mitochondrial 4.0 %: vacuolar 4.0 %: endoplasmic reticulum >> prediction for FC-IC1321 is cyt 5' end seq. ID FC-IC...21E (Link to Original site) FC-IC1321F 194 FC-IC1321Z 194 FC-IC1321P 368 FC-IC1321E 184 Show FC-IC1321 Library FC-IC

  5. Human recombinant antibodies against Plasmodium falciparum merozoite surface protein 3 cloned from peripheral blood leukocytes of individuals with immunity to malaria demonstrate antiparasitic properties

    DEFF Research Database (Denmark)

    Lundquist, Rasmus; Nielsen, Leif Kofoed; Jafarshad, Ali


    against MSP-3 residues 194 to 257 (MSP-3(194-257)) on the molecular level. mRNA from peripheral blood leukocytes from clinically immune individuals was used as a source of Fab (fragment antibody) genes. A Fab-phage display library was made, and three distinct antibodies designated RAM1, RAM2, and RAM3......Immunoglobulins from individuals with immunity to malaria have a strong antiparasitic effect when transferred to Plasmodium falciparum malaria infected patients. One prominent target of antiparasitic antibodies is the merozoite surface antigen 3 (MSP-3). We have investigated the antibody response...... were isolated by panning. Immunoglobulin G1 (IgG1) and IgG3 full-length antibodies have been produced in CHO cells. Reactivity with the native parasite protein was demonstrated by immunofluorescence microscopy, flow cytometry, and immunoblotting. Furthermore, the antiparasitic effect of RAM1 has been...

  6. HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients. (United States)

    Gianotti, N; Canducci, F; Galli, L; Cossarini, F; Salpietro, S; Poli, A; Nozza, S; Spagnuolo, V; Clementi, M; Sampaolo, M; Ceresola, E R; Racca, S; Lazzarin, A; Castagna, A


    In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/10(6) peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p 0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.

  7. High Voltage Properties of Insulating Materials Measured in the Ultra Wideband (United States)


    2.287 3.80 VRI 704 2.516 2.00 Dolphon 1.763 15.00 Conathane 2.265 2.80 Ultem 1000 2.879 3.15 Rexolite 2.069 2.53 Udel 2.755 4.10 Pomalux 2.755 3.80...spec 1 MHz Epoxy 815c/3140 3.73 -- VRI 704 4.00 -- Dolphon 1.10E+07 -- Conathane 4.81E+01 2.80E-02 Ultem 1.72 4.09E-03 Rexolite 1.35 3.04E-04 Udel...815c/3140 none 37 none 266.4 2664 -- VRI 70 23 27 165.6 194.4 1944 2692.4 Conathane 22 27 158.4 194.4 1944 609.6 Ultem 1000 29 33 208.8 237.6 2376

  8. Composition Analysis of Rose Oil Extracted by Molecular Distillation%用分子蒸馏技术提取的玫瑰精油的成分分析

    Institute of Scientific and Technical Information of China (English)

    张静菊; 郭永来; 李凤英; 李洪英


    Through GC-MS analytical method, the compositions of the rose oil extracted by molecular distillation are analyzed, and 78 kinds of chemical compounds have been identified. There are 20 kinds of compound with content more than 1 % , including 22. 606% phenethyl alcohol, 12.015% citronellol, 6.772% geraniol, 6.194% eugenol, and 2.329% neroli alcohol.%采用GC-MS分析方法,对分子蒸馏法提取的玫瑰精油成分进行分析,共鉴定出78种化学成分,含量大于1%的成分20种,其中苯乙醇22.606%、香茅醇12.015%、香叶醇6.772%、丁子香酚6.194%、橙花醇2.329%.

  9. Strain differentiation of Mycobacterium tuberculosis for epidemiology in northwest of Iran. (United States)

    Asgharzadeh, M; Samadi Kafil, H; Pourostadi, M; Asadi Faezi, N; Rashedi, J; Mahdavipour, B


    Tuberculosis is a major health problem throughout the world and there are still a great number of people with the disease. Planning for controlling tuberculosis is required to identify the sources of infection and screening for the disease. The aim of this study is the differentiation of Mycobacterium tuberculosis strains for better understands the spread of the disease in North West Iran. In this study, 194 positive cultures of M. tuberculosis in North West Iran were evaluated by the MIRU-VNTR method. MIRU-12 differentiated the 194 isolates into 138 different patterns, comprising 30 clusters and 108 unique patterns (HGDI=0.9930). The largest cluster contained twelve isolates. The results showed that the majority of TB cases in North West Iran are due to reactivation and the 12-MIRU typing method can be used as a first-line method for strain differentiation of M. tuberculosis.

  10. Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population

    Directory of Open Access Journals (Sweden)

    Duarte Márcia Cristina


    Full Text Available In several DNA repair genes, polymorphisms may result in reduced repair capacity, which has been implicated as a risk factor for various types of cancer. The frequency of the polymorphic alleles varies among populations, suggesting an ethnic distribution of genotypes. We genotyped 300 healthy Southeastern Brazilian individuals (262 of European ancestry and 38 of African ancestry for polymorphisms of codons 194 and 399 of the XRCC1 base excision repair pathway gene and of codon 241 of the XRCC3 homologous recombination repair pathway gene. The allele frequencies were 0.07 for the Arg194Trp and 0.33 for the Arg399Gln codons of the XRCC1 gene and 0.35 for the Thr241Met codon of the XRCC3 gene. The genotypic frequencies were within Hardy-Weinberg equilibrium. These frequencies showed ethnic variability when compared with those obtained for different populations from several countries.

  11. Pelayanan Pendidikan, Medis, dan Sosial bagi Anak Cacat Secara Terpadu

    Directory of Open Access Journals (Sweden)

    Sunardi Sunardi


    Full Text Available This study was an effort to introduce mainstreaming in which regular schools were prepared to educate handicapped children. The study was conducted in 5 villages in Mojosongo, Boyolali. There were 19 primary schools with 4 special education teachers as itinerant teachers. It was found out that training in special education improved knowledge in special education and ability to identify handicapped children. A number of 202 handicapped children were identified (7.9% of the population. A number of 194 children received special education services in their regular classrooms. Of the 194 students, 110 of this promotion did not affect school ranks and repetition rates. Most teachers agreed that the gifted, slow learner, and learning disabled remain in the regular school with special services by special education teachers

  12. Drug: D04006 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D04006 Drug Enprofylline (USAN/INN) C8H10N4O2 194.0804 194.1906 D04006.gif Adenosine adenosine A1 receptor [HSA:134] [KO:K04265] Enprofylline D04006 Enprofylline (USAN/INN) A2a receptor [HSA:135] [KO:K04266] Enprofylline D04006 Enprofylline (USAN/INN)... adenosine A2b receptor [HSA:136] [KO:K04267] Enprofylline D04006 Enprofylline (USAN/INN) CAS: 41078-02-8 Pu...bChem: 17398000 DrugBank: DB00824 LigandBox: D04006 NIKKAJI: J16.542E ATOM 14 1 N4x N 14.2100 -16.5200 2 C8y

  13. Interleukin-6: the missing element of the neurocognitive deterioration in schizophrenia? The focus on genetic underpinnings, cognitive impairment and clinical manifestation


    Frydecka, Dorota; Misiak, Błażej; Pawlak-Adamska,Edyta; Karabon, Lidia; Tomkiewicz, Anna; Sedlaczek, Paweł; Kiejna, Andrzej; Beszłej, Jan Aleksander


    The influence of the immune system deregulation on the risk of schizophrenia is increasingly recognized. The aim of this study was to assess the influence of serum interleukin-6 (IL-6) level together with the polymorphism in its gene (IL6 -174G/C) and high sensitivity C-reactive protein (hsCRP) levels on clinical manifestation and cognition in schizophrenia patients. We recruited 151 patients with schizophrenia and 194 healthy control subjects. Psychopathology was evaluated using Operational ...

  14. Some Problems and Solutions of Applying TBLT in a Chinese Large-sized Class

    Institute of Scientific and Technical Information of China (English)



    This paper mainly looks into the problems of applying Task-based Language Teaching(TBLT) and possible solutions to them.TBLT is now also widely used in Chinese classrooms.It can also be called as "the Age of Task"(Johnson,2001: P.194).However,there are still some problems when TBLT is applied in China.Most of the problems are caused by the large class size and examination-oriented education in China.

  15. Hybrid Particle-Continuum Numerical Methods for Aerospace Applications (United States)


    Numerical Methods for Aerospace Applications 6 - 2 RTO-EN-AVT-194 2.1 Micro-Scale Flows Recently, an increase in the development of micro- and nano ...equations predict a separation bubble that forms along the surface that is signicantly larger than experimental measurements. In general, DSMC...and Rockets, Vol. 31, No. 6, 1994, pp. 971979. [3] McNeely, M., Microturbine Designed for Mechanical Drive Applications, Diesel Progress North

  16. Mechanisms in Chronic Multisymptom Illnesses (United States)


    experimental pain, mi- croinjection of morphine into the anterior cingulate dose- dependently reduced affective components of pain greater than sensory...Pain 127:183–194. Manning BH (1998) A lateralized deficit in morphine antinociception after unilateral inactivation of the central amygdala. J...the hippocampus of indi- viduals with FM (32), whereas we observed increased NAA levels in the posterior insula, although this was only a trend. In

  17. Highly stable, efficient Tm-doped fiber laser—a potential scalpel for low invasive surgery (United States)

    Michalska, M.; Brojek, W.; Rybak, Z.; Sznelewski, P.; Mamajek, M.; Swiderski, J.


    We report an all-fiber, diode-pumped, continuous-wave Tm3+-doped fiber laser emitting 37.4 W of output power with a slope efficiency as high as 57% with respect to absorbed pump power at 790 nm. The laser operated at ~1.94 µm and the output beam quality factor M 2 was measured to be ~1.2. The output beam was very stable with power fluctuations  surgery.

  18. Annual Change Report 2006/2007

    Energy Technology Data Exchange (ETDEWEB)

    Washington Regulatory and Environmental Services; Washington TRU Solutions LLC


    As part of continuing compliance, the U.S. Environmental Protection Agency (EPA) requires the U.S. Department of Energy (DOE) to provide information on any change in conditions or activities pertaining to the disposal system since the most recent compliance application. This requirement is identified in Title 40 Code of Federal Regulations (CFR), Section 194.4(b)(4), which states: "No later than six months after the administrator issues a certification, and at least annually thereafter, the Department shall report to the Administrator, in writing, any changes in conditions or activities pertaining to the disposal system that were not required to be reported by paragraph (b)(3) of this section and that differ from information contained in the most recent compliance application." In meeting the requirement, the DOE provides an annual report each November of all applicable changes under the above requirement. This annual report informs the EPA of changes to information in the most recent compliance recertification (the 2004 Compliance Recertification). Significant planned changes must be reported to the EPA prior to implementation by the DOE. In addition, Title 40 CFR, Section 194.4(b)(3) requires that significant unplanned changes be reported to the EPA within 24 hours or ten days, depending on the severity of the activity or condition. To date, there have been no significant unplanned changes to the certification basis. Planned changes have been submitted on an individual basis. All other changes are reported annually. Changes in activities or conditions are reviewed to determine if 40 CFR Section 194.4(b)(3) reporting is necessary. As indicated above, no significant unplanned changes were identified for the time period covered by this report. The enclosed tables list those items identified for reporting under 40 CFR Section 194.4(b)(4). The majority of the items described in this report are inspections, reports, and modifications to written plans and procedures for

  19. Defence Transformation with Frictions - The Case of Sweden (United States)


    Back to Barbarism. Carnegie Endowment for International Peace. Washington D C 2007, s 175-181. FMV: LedsysT Historia . En resumé av 4 faser. 2010-03...behind us” in Knox, M and Murray, W (red): The Dynamics of military revolution 1300-2050. Cambridge University Press 2001 Ch 10, 99 175-194. NATO/RTO...Worst-Case Scenarios. Harvard University Press. Cambridge, Massachusetts. 2007. THE MILITARY BALANCE 2010. IISS. London 2010. Witney, N.: Re

  20. Polymorphism of the NFKB1 affects the serum inflammatory levels of IL-6 in Hashimoto thyroiditis in a Turkish population. (United States)

    Koc, Arzuhan; Batar, Bahadir; Celik, Ozlem; Onaran, Ilhan; Tasan, Ertugrul; Sultuybek, Gonul Kanigur


    Hashimoto thyroiditis (HT) is a chronic inflammatory autoimmune disease of thyroid gland affected by interaction of multiple genes and various cytokines. Variants in the genes coding for the NFKB and IKB proteins can be potentially involved in the development of the inflammatory diseases. NFKB, a key transcription factor of the regulation of immune responses, is interesting candidate for association studies about autoimmune disorder. The aim of the present study was to investigate the relationship between NFKB1 and NFKBIA (NFKB1 inhibitor gene) polymorphisms, and the risk of HT in a Turkish Population in the context of IL-6 serum levels which may contribute to susceptibility to the disease. We analyzed the distribution of NFKB1-94ins/del ATTG and NFKBIA 3'UTR A→G polymorphisms using PCR-RFLP method and IL-6 serum levels using ELISA method in 120 HT patients and 190 healthy controls in Turkish population. Although, there was no statistical significant difference in distribution of the genotypes and alleles of NFKB1-94ins/del ATTG or NFKBIA 3'UTR A→G polymorphisms in patients and control subjects as single, ins/ins/GG combined genotype had protective effect on the disease when compared to ins/ins/AG combined genotype as combined genotypes of both polymorphisms. In addition to this finding, IL-6 serum levels in HT patients with del/del genotype were significantly higher than in patients with del/ins genotype (p<0.001). According to the combined genotype analysis of NFKB1-94ins/del ATTG and NFKBIA 3'UTR A→G polymorphisms, IL-6 levels were also higher in patients with del/del genotype when at least one G allele existing (p=0.007). Therefore, our findings suggest that the functional promoter NFKB1-94ins/del ATTG polymorphism was significantly associated with population HT disease through acting by directly modulating IL-6 serum levels.

  1. [Case of anti VGKC-complex antibody associated disorder presenting with severe pain and fasciculations predominant in unilateral upper extremity]. (United States)

    Hara, Kenju; Watanabe, Osamu; Shibano, Ken; Ishiguro, Hideaki


    A 21-year-old man complained of severe pain and muscle twitching localized in his right arm. Neurological examination showed muscle fasciculations in his right forearm but no myokymia or myotonia. Needle electromyography revealed fibrillation potentials in his biceps brachii muscle and extensor carpi radialis muscle at rest but no myokymic discharges. His serum anti-voltage-gated potassium channel (VGKC)-complex antibody level was significantly high (194.2pM; controls VGKC-complex antibody associated disorder.

  2. Toxicity Evaluation of Engineered Nanomaterials (Phase 1 Studies) (United States)


    EDTA, 1% Nonidet P - 40 ) supplemented with Complete Mini Protease Inhibitor Cocktail (Roche Diagnostics, Indianapolis, IN) and frozen at -80°C for at...1996, 59, 61–83. [ 40 ] Providence, K.; Higgins, S.; Mullen, A.; Battista, A.; Samarakoon, R.; Higgins, C.; Wilkins- Port, C.; Higgins, P . SERPINE1...94 Figure 40 . Comparison images of CuO NP 40nm at 6 months. .................................. 94 Figure 41. Comparison images of Cu MSP

  3. Multiple Cationic Amphiphiles Induce a Niemann-Pick C Phenotype and Inhibit Ebola Virus Entry and Infection (United States)


    Antiviral Res 87: 187–194. 32. Balch WE, Rothman JE (1985) Characterization of protein transport between successive compartments of the Golgi ... apparatus : asymmetric properties of donor and acceptor activities in a cell-free system. Arch Biochem Biophys 240: 413– 425. 33. Kobayashi T, Beuchat MH...transiently associates with lysosomes and the trans- Golgi network. Mol Genet Metab 68: 1–13. 47. Ko DC, Gordon MD, Jin JY, Scott MP (2001) Dynamic

  4. New Diazo Process (United States)


    those based on pyrene include colorless photodegradation products and good availability of raw materials without sacrifice of spectral...34Diazotype Proesses", John Wiley « Sons, Inc., 1965 pp. 194-302. 5. Rys Ä Zollinger, Fundamentals of the Chemistry & Application of Dyes ...Co., London, 1949. 7. Venkatararnan, The Chemistry of Synthetic Dyes , Vol. I and II. First Ed., Academic Press, 1952. Journals 8. Brown, "The Basis

  5. The North Korean Ballistic Missile Program (United States)


    Future Preemptive Strikes against North Korea ,” The Korean Journal of Defense Analysis, Vol. 18, No. 4, Winter 2006, pp. 95-121. 194. Joseph S...University of California, San Diego; and Korea University. He also served as a Korean linguist in the United States Air Force. His publications have...appeared in Asian Perspective, Astropolitics, The Journal of East Asian Studies, The Korea Journal of Defense Analysis, The KNDU Review, The

  6. Measurements of the $ \\mathrm{ pp \\to W \\gamma\\gamma } $ and $ \\mathrm{ pp \\to Z \\gamma\\gamma } $ cross sections and limits on anomalous quartic gauge couplings at $ \\sqrt{s} = $ 8 TeV

    CERN Document Server

    Sirunyan, Albert M; CMS Collaboration; Adam, Wolfgang; Aşılar, Ece; Bergauer, Thomas; Brandstetter, Johannes; Brondolin, Erica; Dragicevic, Marko; Erö, Janos; Flechl, Martin; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hartl, Christian; Krammer, Natascha; Hrubec, Josef; Jeitler, Manfred; König, Axel; Krätschmer, Ilse; Liko, Dietrich; Matsushita, Takashi; Mikulec, Ivan; Rabady, Dinyar; Rad, Navid; Rahbaran, Babak; Rohringer, Herbert; Schieck, Jochen; Strauss, Josef; Waltenberger, Wolfgang; Wulz, Claudia-Elisabeth; Dvornikov, Oleg; Makarenko, Vladimir; Mossolov, Vladimir; Suarez Gonzalez, Juan; Zykunov, Vladimir; Shumeiko, Nikolai; Alderweireldt, Sara; De Wolf, Eddi A; Janssen, Xavier; Lauwers, Jasper; Van De Klundert, Merijn; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Abu Zeid, Shimaa; Blekman, Freya; D'Hondt, Jorgen; Daci, Nadir; De Bruyn, Isabelle; Deroover, Kevin; Lowette, Steven; Moortgat, Seth; Moreels, Lieselotte; Olbrechts, Annik; 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Aleksandrov, Aleksandar; Hadjiiska, Roumyana; Iaydjiev, Plamen; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Shopova, Mariana; Dimitrov, Anton; Glushkov, Ivan; Litov, Leander; Pavlov, Borislav; Petkov, Peicho; Fang, Wenxing; Gao, Xuyang; Ahmad, Muhammad; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Chen, Mingshui; Chen, Ye; Cheng, Tongguang; Jiang, Chun-Hua; Leggat, Duncan; Liu, Zhenan; Romeo, Francesco; Ruan, Manqi; Shaheen, Sarmad Masood; Spiezia, Aniello; Tao, Junquan; Wang, Chunjie; Wang, Zheng; Yazgan, Efe; Zhang, Huaqiao; Zhao, Jingzhou; Ban, Yong; Chen, Geng; Li, Qiang; Liu, Shuai; Mao, Yajun; Qian, Si-Jin; Wang, Dayong; Xu, Zijun; Avila, Carlos; Cabrera, Andrés; Chaparro Sierra, Luisa Fernanda; Florez, Carlos; Gomez, Juan Pablo; González Hernández, Carlos Felipe; Ruiz Alvarez, José David; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Puljak, Ivica; Ribeiro Cipriano, Pedro M; Sculac, Toni; Antunovic, Zeljko; Kovac, Marko; Brigljevic, Vuko; Ferencek, Dinko; Kadija, Kreso; Mesic, Benjamin; Susa, Tatjana; Ather, Mohsan Waseem; Attikis, Alexandros; Mavromanolakis, Georgios; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Rykaczewski, Hans; Finger, Miroslav; Finger Jr, Michael; Carrera Jarrin, Edgar; El-khateeb, Esraa; Elgammal, Sherif; Mohamed, Amr; Kadastik, Mario; Perrini, Lucia; Raidal, Martti; Tiko, Andres; Veelken, Christian; Eerola, Paula; Pekkanen, Juska; Voutilainen, Mikko; Härkönen, Jaakko; Jarvinen, Terhi; Karimäki, Veikko; Kinnunen, Ritva; Lampén, Tapio; Lassila-Perini, Kati; Lehti, Sami; Lindén, Tomas; Luukka, Panja-Riina; Tuominiemi, Jorma; Tuovinen, Esa; Wendland, Lauri; Talvitie, Joonas; Tuuva, Tuure; Besancon, Marc; Couderc, Fabrice; Dejardin, Marc; Denegri, Daniel; Fabbro, Bernard; Faure, Jean-Louis; Favaro, Carlotta; Ferri, Federico; Ganjour, Serguei; Ghosh, Saranya; Givernaud, Alain; Gras, Philippe; Hamel de Monchenault, Gautier; Jarry, Patrick; Kucher, Inna; Locci, Elizabeth; Machet, Martina; Malcles, Julie; Rander, John; 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Braghieri, Alessandro; Fallavollita, Francesco; Magnani, Alice; Montagna, Paolo; Ratti, Sergio P; Re, Valerio; Ressegotti, Martina; Riccardi, Cristina; Salvini, Paola; Vai, Ilaria; Vitulo, Paolo; Alunni Solestizi, Luisa; Bilei, Gian Mario; Ciangottini, Diego; Fanò, Livio; Lariccia, Paolo; Leonardi, Roberto; Mantovani, Giancarlo; Mariani, Valentina; Menichelli, Mauro; Saha, Anirban; Santocchia, Attilio; Androsov, Konstantin; Azzurri, Paolo; Bagliesi, Giuseppe; Bernardini, Jacopo; Boccali, Tommaso; Castaldi, Rino; Ciocci, Maria Agnese; Dell'Orso, Roberto; Fedi, Giacomo; Giassi, Alessandro; Grippo, Maria Teresa; Ligabue, Franco; Lomtadze, Teimuraz; Martini, Luca; Messineo, Alberto; Palla, Fabrizio; Rizzi, Andrea; Savoy-Navarro, Aurore; Spagnolo, Paolo; Tenchini, Roberto; Tonelli, Guido; Venturi, Andrea; Verdini, Piero Giorgio; Barone, Luciano; Cavallari, Francesca; Cipriani, Marco; Del Re, Daniele; Diemoz, Marcella; Gelli, Simone; Longo, Egidio; Margaroli, Fabrizio; Marzocchi, Badder; Meridiani, Paolo; 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Carpinteyro, Severiano; Pedraza, Isabel; Salazar Ibarguen, Humberto Antonio; Uribe Estrada, Cecilia; Morelos Pineda, Antonio; Krofcheck, David; Butler, Philip H; Ahmad, Ashfaq; Ahmad, Muhammad; Hassan, Qamar; Hoorani, Hafeez R; Khan, Wajid Ali; Saddique, Asif; Shah, Mehar Ali; Shoaib, Muhammad; Waqas, Muhammad; Bialkowska, Helena; Bluj, Michal; Boimska, Bożena; Frueboes, Tomasz; Górski, Maciej; Kazana, Malgorzata; Nawrocki, Krzysztof; Romanowska-Rybinska, Katarzyna; Szleper, Michal; Zalewski, Piotr; Bunkowski, Karol; Byszuk, Adrian; Doroba, Krzysztof; Kalinowski, Artur; Konecki, Marcin; Krolikowski, Jan; Misiura, Maciej; Olszewski, Michal; Pyskir, Andrzej; Walczak, Marek; Bargassa, Pedrame; Beirão Da Cruz E Silva, Cristóvão; Calpas, Betty; Di Francesco, Agostino; Faccioli, Pietro; Gallinaro, Michele; Hollar, Jonathan; Leonardo, Nuno; Lloret Iglesias, Lara; Nemallapudi, Mythra Varun; Seixas, Joao; Toldaiev, Oleksii; Vadruccio, Daniele; Varela, Joao; Afanasiev, Serguei; Bunin, Pavel; Gavrilenko, Mikhail; Golutvin, Igor; Gorbunov, Ilya; Kamenev, Alexey; Karjavin, Vladimir; Lanev, Alexander; Malakhov, Alexander; Matveev, Viktor; Palichik, Vladimir; Perelygin, Victor; Shmatov, Sergey; Shulha, Siarhei; Skatchkov, Nikolai; Smirnov, Vitaly; Voytishin, Nikolay; Zarubin, Anatoli; Chtchipounov, Leonid; Golovtsov, Victor; Ivanov, Yury; Kim, Victor; Kuznetsova, Ekaterina; Murzin, Victor; Oreshkin, Vadim; Sulimov, Valentin; Vorobyev, Alexey; Andreev, Yuri; Dermenev, Alexander; Gninenko, Sergei; Golubev, Nikolai; Karneyeu, Anton; Kirsanov, Mikhail; Krasnikov, Nikolai; Pashenkov, Anatoli; Tlisov, Danila; Toropin, Alexander; Epshteyn, Vladimir; Gavrilov, Vladimir; Lychkovskaya, Natalia; Popov, Vladimir; Pozdnyakov, Ivan; Safronov, Grigory; Spiridonov, Alexander; Toms, Maria; Vlasov, Evgueni; Zhokin, Alexander; Aushev, Tagir; Bylinkin, Alexander; Chadeeva, Marina; Rusinov, Vladimir; Tarkovskii, Evgenii; Andreev, Vladimir; Azarkin, Maksim; Dremin, Igor; Kirakosyan, Martin; Leonidov, Andrey; Terkulov, Adel; 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Ferguson, Thomas; Paulini, Manfred; Russ, James; Sun, Menglei; Vogel, Helmut; Vorobiev, Igor; Weinberg, Marc; Cumalat, John Perry; Ford, William T; Jensen, Frank; Johnson, Andrew; Krohn, Michael; Leontsinis, Stefanos; Mulholland, Troy; Stenson, Kevin; Wagner, Stephen Robert; Alexander, James; Chaves, Jorge; Chu, Jennifer; Dittmer, Susan; Mcdermott, Kevin; Mirman, Nathan; Patterson, Juliet Ritchie; Rinkevicius, Aurelijus; Ryd, Anders; Skinnari, Louise; Soffi, Livia; Tan, Shao Min; Tao, Zhengcheng; Thom, Julia; Tucker, Jordan; Wittich, Peter; Zientek, Margaret; Winn, Dave; Abdullin, Salavat; Albrow, Michael; Apollinari, Giorgio; Apresyan, Artur; Banerjee, Sunanda; Bauerdick, Lothar AT; Beretvas, Andrew; Berryhill, Jeffrey; Bhat, Pushpalatha C; Bolla, Gino; Burkett, Kevin; Butler, Joel Nathan; Cheung, Harry; Chlebana, Frank; Cihangir, Selcuk; Cremonesi, Matteo; Duarte, Javier; Elvira, Victor Daniel; Fisk, Ian; Freeman, Jim; Gottschalk, Erik; Gray, Lindsey; Green, Dan; Grünendahl, Stefan; 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Curry, David; Das, Souvik; Field, Richard D; Furic, Ivan-Kresimir; Konigsberg, Jacobo; Korytov, Andrey; Low, Jia Fu; Ma, Peisen; Matchev, Konstantin; Mei, Hualin; Mitselmakher, Guenakh; Rank, Douglas; Shchutska, Lesya; Sperka, David; Thomas, Laurent; Wang, Jian; Wang, Sean-Jiun; Yelton, John; Linn, Stephan; Markowitz, Pete; Martinez, German; Rodriguez, Jorge Luis; Ackert, Andrew; Adams, Todd; Askew, Andrew; Bein, Samuel; Hagopian, Sharon; Hagopian, Vasken; Johnson, Kurtis F; Kolberg, Ted; Perry, Thomas; Prosper, Harrison; Santra, Arka; Yohay, Rachel; Baarmand, Marc M; Bhopatkar, Vallary; Colafranceschi, Stefano; Hohlmann, Marcus; Noonan, Daniel; Roy, Titas; Yumiceva, Francisco; Adams, Mark Raymond; Apanasevich, Leonard; Berry, Douglas; Betts, Russell Richard; Cavanaugh, Richard; Chen, Xuan; Evdokimov, Olga; Gerber, Cecilia Elena; Hangal, Dhanush Anil; Hofman, David Jonathan; Jung, Kurt; Kamin, Jason; Sandoval Gonzalez, Irving Daniel; Trauger, Hallie; Varelas, Nikos; Wang, Hui; Wu, Zhenbin; Zhang, Jingyu; Bilki, Burak; Clarida, Warren; Dilsiz, Kamuran; Durgut, Süleyman; Gandrajula, Reddy Pratap; Haytmyradov, Maksat; Khristenko, Viktor; Merlo, Jean-Pierre; Mermerkaya, Hamit; Mestvirishvili, Alexi; Moeller, Anthony; Nachtman, Jane; Ogul, Hasan; Onel, Yasar; Ozok, Ferhat; Penzo, Aldo; Snyder, Christina; Tiras, Emrah; Wetzel, James; Yi, Kai; Blumenfeld, Barry; Cocoros, Alice; Eminizer, Nicholas; Fehling, David; Feng, Lei; Gritsan, Andrei; Maksimovic, Petar; Roskes, Jeffrey; Sarica, Ulascan; Swartz, Morris; Xiao, Meng; You, Can; Al-bataineh, Ayman; Baringer, Philip; Bean, Alice; Boren, Samuel; Bowen, James; Castle, James; Forthomme, Laurent; Khalil, Sadia; Kropivnitskaya, Anna; Majumder, Devdatta; Mcbrayer, William; Murray, Michael; Sanders, Stephen; Stringer, Robert; Tapia Takaki, Daniel; Wang, Quan; Ivanov, Andrew; Kaadze, Ketino; Maravin, Yurii; Mohammadi, Abdollah; Saini, Lovedeep Kaur; Skhirtladze, Nikoloz; Toda, Sachiko; Rebassoo, Finn; Wright, Douglas; Anelli, Christopher; Baden, Drew; Baron, Owen; Belloni, Alberto; Calvert, Brian; Eno, Sarah Catherine; Ferraioli, Charles; Hadley, Nicholas John; Jabeen, Shabnam; Jeng, Geng-Yuan; Kellogg, Richard G; Kunkle, Joshua; Mignerey, Alice; Ricci-Tam, Francesca; Shin, Young Ho; Skuja, Andris; Tonjes, Marguerite; Tonwar, Suresh C; Abercrombie, Daniel; Allen, Brandon; Apyan, Aram; Azzolini, Virginia; Barbieri, Richard; Baty, Austin; Bi, Ran; Bierwagen, Katharina; Brandt, Stephanie; Busza, Wit; Cali, Ivan Amos; D'Alfonso, Mariarosaria; Demiragli, Zeynep; Gomez Ceballos, Guillelmo; Goncharov, Maxim; Hsu, Dylan; Iiyama, Yutaro; Innocenti, Gian Michele; Klute, Markus; Kovalskyi, Dmytro; Krajczar, Krisztian; Lai, Yue Shi; Lee, Yen-Jie; Levin, Andrew; Luckey, Paul David; Maier, Benedikt; Marini, Andrea Carlo; Mcginn, Christopher; Mironov, Camelia; Narayanan, Siddharth; Niu, Xinmei; Paus, Christoph; Roland, Christof; Roland, Gunther; Salfeld-Nebgen, Jakob; Stephans, George; Tatar, Kaya; Velicanu, Dragos; Wang, Jing; Wang, Ta-Wei; 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Li, Hengne; Neu, Christopher; Sinthuprasith, Tutanon; Sun, Xin; Wang, Yanchu; Wolfe, Evan; Xia, Fan; Clarke, Christopher; Harr, Robert; Karchin, Paul Edmund; Sturdy, Jared; Zaleski, Shawn; Belknap, Donald; Buchanan, James; Caillol, Cécile; Dasu, Sridhara; Dodd, Laura; Duric, Senka; Gomber, Bhawna; Grothe, Monika; Herndon, Matthew; Hervé, Alain; Hussain, Usama; Klabbers, Pamela; Lanaro, Armando; Levine, Aaron; Long, Kenneth; Loveless, Richard; Pierro, Giuseppe Antonio; Polese, Giovanni; Ruggles, Tyler; Savin, Alexander; Smith, Nicholas; Smith, Wesley H; Taylor, Devin; Woods, Nathaniel


    Measurements are presented of $ \\mathrm{ W \\gamma\\gamma } $ and $ \\mathrm{ Z \\gamma\\gamma } $ production in proton-proton collisions. Fiducial cross sections are reported based on a data sample corresponding to an integrated luminosity of 19.4 fb$^{-1}$ collected with the CMS detector at a center-of-mass energy of 8 TeV. Signal is identified through the $\\mathrm{ W } \\to \\ell\

  7. CYP2D6 genotype determination in the Danish population

    DEFF Research Database (Denmark)

    Brøsen, K; Nielsen, P N; Brusgaard, K


    .741 (0.026) in the Danish population and the second most common allele was the D6-B with an apparent frequency of 0.194 (0.024). The median (range) of the sparteine metabolic ratio (MR) in 47 homozygous D6-wt EM was 0.28 (0.11-4.10) and the corresponding value in heterozygous EM was 0.36 (0...

  8. AcEST: DK954681 [AcEST

    Lifescience Database Archive (English)

    Full Text Available . 253 8e-66 tr|B8A187|B8A187_MAIZE Putative uncharacterized protein OS=Zea m... 252 1e-65 tr|Q6T7C8|Q6T7C8_GOSBA Fiber...uery: 575 TCGARNIELVKSLGAD 622 TCGARN+ELVKSLGAD Sbjct: 194 TCGARNVELVKSLGAD 209 >tr|Q6T7C8|Q6T7C8_GOSBA Fiber

  9. Icelandic Inland Wetlands: Characteristics and Extent of Draining


    Gudmundsson, Jon; Brink, Sigmundur H.; Arnalds, Olafur; Gisladottir, Fanney O.; Oskarsson, Hlynur


    Iceland has inland wetland areas with soils exhibiting both Andosol and Histosol properties which are uncommon elsewhere on Earth. They are generally fertile, with higher bird-nest densities than in similar wetlands in the neighboring countries, with nutrients released by rapid weathering of aeolian materials of basaltic nature. Icelandic inland wetlands cover about 9000 km2 constituting 19.4 % of the vegetated surfaces of the island. The wetland soils are often 1–3 m thick and store 33 to >1...

  10. On the Development of Constitutive Relations for Plain and Reinforced Concrete. (United States)


    4.3.1 Variable Modulus Models ............ ... 183 4.3.2 Hypoelastic Models ..... ............. 185 4.3.3 Elastic Plastic Models . .......... .... 186...simplest structures. 4.3.2 Hypoelastic Models Coon and Evans (144 ) starting from the general representation of a hypoelastic material developed an...Recommendations Many models for plain concrete triaxial response have been developed. The variable modulus and hypoelastic theories are of no 194

  11. Studio caso-controllo sulle determinanti individuali e ambientali dell'Interruzione Volontaria di Gravidanza in Abruzzo



    OBIETTIVI: L'interruzione volontaria di gravidanza (IVG), legalizzata in Italia dalla L. 194/78 ? sottoposta a un sistema di sorveglianza con notifica obbligatoria di tutti i casi secondo un modello ISTAT nazionale che consente la descrizione del fenomeno mediante misure epidemiologiche specifiche, anche rispetto a variabili di tipo socio-demografico, ma non la conoscenza dei fattori di rischio e di protezione modificabili. Obiettivo dell'indagine ? stata l'analisi di variabili determinanti i...

  12. 78 FR 77144 - Announcement of Funding Awards for Fiscal Year 2013 for the Housing Choice Voucher Program (United States)


    ..., SPRINGFIELD, MO 65806. MT: HELENA HA 812 ABBEY ST, 0 7,200 HELENA, MT 59601. ND: HA OF CASS COUNTY........ 230... CURTIS DR, STE 112. Total for Witness 16 194,046 Relocation. Total for Public Housing 5,057 21,780,820...: HELENA HA 812 ABBEY ST, 36 103,159 HELENA, MT 59601. ND: HA OF CASS COUNTY........ 230 8TH AVE 7...

  13. Drug: D02600 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D02600 Drug Demoxepam (USAN/INN) C15H11ClN2O2 286.0509 286.713 D02600.gif Tranquili...zer [minor] CAS: 963-39-3 PubChem: 17396770 LigandBox: D02600 NIKKAJI: J7.197H ATOM 20 1 C2y C 33.0371 -19.4

  14. Bank level stability factors and consumer confidence – a comparative study of Islamic and conventional banks’ product mix


    Hussein, Kassim


    This study examines the behaviour of key bank level stability factors of liquidity, capital, risk-taking and consumer confidence in Islamic and conventional banks which operate in the same market. Using fixed effect sample of 194 banks of Gulf Cooperating Countries between 2000 and 2007, we found that liquidity is not determined by bank’s product mix but rather attributed to systematic factors. However, non performing assets (representing loans to sub prime borrowers) have positive and signif...

  15. Las infancias que vivimos

    Directory of Open Access Journals (Sweden)

    Pablo Rodríguez Jiménez


    Full Text Available Los niños que fuimos: huellas de la infancia en Colombia. Patricia Londoño Vega y Santiago Londoño Vélez (investigación y curaduría Biblioteca Luis Ángel Arango, Banco de la República (catálogo de la exposición, Bogotá, 2012, 194 págs, il.

  16. Gclust Server: 157090 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available tive protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyc...157090 SCE_YGL194C-A Cluster Sequences - 80 Putative protein of unknown function, identified based on compar...isons of the genome sequences of six Saccharomyces species 1 1.00e-40 0.0 0.0 0.0 0

  17. Continuous-wave operation of a room-temperature Tm: YAP-pumped Ho: YAG laser

    Institute of Scientific and Technical Information of China (English)


    We report a continuous-wave (CW) 2.1-μm Ho:YAG laser operating at room temperature pumped by a diode-pumped 1.94-?m Tm:YAP laser.The maximum output power of 1.5 W is obtained from Ho:YAG laser,corresponding to Tm-to-Ho slope efficiency of 17.9% and diode-to-He conversion efficiency of 5.6%.

  18. List of Publications of the U.S. Army Engineer Waterways Experiment Station. Volume 2 (United States)


    Enhance Transplants of the AD A188 172 Seagrasses Zostera Marina and Halodule Wrightii , by M. S. Fonseca, W. J. Kenworthy, Keith Rittmaster, and G. W...88-6 Apr 1988 A Survey of the Fauna Associated with Pistia Stratiotes AD A194 188 L. (Waterlettuce) in Florida, by F. A. Dray, Jr., C. R. Thompson, D...Investigation of the Short-Term Effects of AD A200 176 Storms on Sedimentary Characteristics and the Nearshore Fauna Using the Sediment Profiling Camera

  19. EST Table: FS768368 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FS768368 E_FL_fcaL_48N17_F_0 10/09/28 78 %/215 aa ref|NP_001161754.1| integrin beta...otein|X:14937399:14948907:1|gene:INTB 10/09/10 40 %/194 aa gnl|Amel|GB19541-PA 10/09/10 43 %/192 aa gi|270014241|gb|EFA10689.1| myospheroid [Tribolium castaneum] FS932451 fcaL ...

  20. Raman spectroscopic study of DL valine under pressure up to 20 GPa (United States)

    Rêgo, F. S. C.; Lima, J. A.; Freire, P. T. C.; Melo, F. E. A.; Mendes Filho, J.; Polian, A.


    DL-valine crystal was studied by Raman spectroscopy under hydrostatic pressure using a diamond anvil cell from ambient pressure up to 19.4 GPa in the spectral range from 40 to 3300 cm-1. Modifications in the spectra furnished evidence of the occurrence of two structural phase transitions undergone by this racemic amino acid crystal. The classification of the vibrational modes, the behavior of their wavenumber as a function of the pressure and the reversibility of the phase transitions are discussed.

  1. AcEST: BP911852 [AcEST

    Lifescience Database Archive (English)

    Full Text Available binding protein OS=Arabidops... 194 2e-48 tr|A9PC45|A9PC45_POPTR Putative uncharacterized protein OS=Popul... 192 1e-47 tr|A5BWR...2|A5BWR2_VITVI Putative uncharacterized protein OS=Vitis... 191 2e-47 tr|A7QW72|A7QW72_...G DE Sbjct: 121 INAEKSPFLAEKLKILVLPTLALIKNAKVDDYVVGFDE 158 >tr|A5BWR2|A5BWR2_VITVI Putative uncharacterized

  2. Inference for a Nonlinear Semimartingale Regression Model. (United States)


    increases. If K is left continuous and of bounded variation , then by integration by parts (see Dellacherie and Meyer (1982), Chapter VIII, (19.4)) for n...dt uniformly in z as n oo, where x- = .K 2(u) du. (c) Suppose A1-A3, B1, B2 hold, K is left continuous, of bounded variation and nwn - 00, nw 3 -3 0

  3. Trends in Navy Waste Reduction and Materials Markets. (United States)


    su. - -e transient, It may not be poe - under pressure of carbonation. Cups and lower beverage prices for consumers. sible to use returnable containers...193 "Is Paper Industry Doomed by Electronic Publishing?" David R. Allan ,Pulp & Paper, October 1980. 194 "Steel Industry, USA: The Ubiquitous Electric...Paper Industry Doomed by Electronic Publishing?", by David R. Allan , News Editor, Pulp & Paper, October 1980. [193] ISIS Handbook. Institute of Scrap

  4. H1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1. (United States)

    Tijsma, Aloys; Thibaut, Hendrik Jan; Spieser, Stéphane A H; De Palma, Armando; Koukni, Mohamed; Rhoden, Eric; Oberste, Steve; Pürstinger, Gerhard; Volny-Luraghi, Antonia; Martin, Javier; Marchand, Arnaud; Chaltin, Patrick; Neyts, Johan; Leyssen, Pieter


    A novel small molecule, H1PVAT, was identified as a potent and selective inhibitor of the in vitro replication of all three poliovirus serotypes, whereas no activity was observed against other enteroviruses. Time-of-drug-addition studies revealed that the compound interfered with an early stage of virus replication. Four independently-selected H1PVAT-resistant virus variants uniformly carried the single amino acid substitution I194F in the VP1 capsid protein. Poliovirus type 1 strain Sabin, reverse-engineered to contain this substitution, proved to be completely insensitive to the antiviral effect of H1PVAT and was cross-resistant to the capsid-binding inhibitors V-073 and pirodavir. The VP1 I194F mutant had a smaller plaque phenotype than wild-type virus, and the amino acid substitution rendered the virus more susceptible to heat inactivation. Both for the wild-type and VP1 I194F mutant virus, the presence of H1PVAT increased the temperature at which the virus was inactivated, providing evidence that the compound interacts with the viral capsid, and that capsid stabilization and antiviral activity are not necessarily correlated. Molecular modeling suggested that H1PVAT binds with high affinity in the pocket underneath the floor of the canyon that is involved in receptor binding. Introduction of the I194F substitution in the model of VP1 induced a slight concerted rearrangement of the core β-barrel in this pocket, which disfavors binding of the compound. Taken together, the compound scaffold, to which H1PVAT belongs, may represent another promising class of poliovirus capsid-binding inhibitors next to V-073 and pirodavir. Potent antivirals against poliovirus will be essential in the poliovirus eradication end-game.

  5. Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy.



    Various conformational forms of the archetypal serpin human alpha 1proteinase inhibitor (alpha 1PI), including ordered polymers, active and inactive monomers, and heterogeneous aggregates, have been produced by refolding from mild denaturing conditions. These forms presumably originate by different folding pathways during renaturation, under the influence of the A and C sheets of the molecule. Because alpha 1PI contains only two Trp residues, at positions 194 and 238, it is amenable to fluore...

  6. A Thirsty Nation

    Institute of Scientific and Technical Information of China (English)


    Since 1950, lake areas in China have shrunk by 15 percent, and marshes by more than 25 percent. Meanwhile, water consumption has increased 500 percent, with per-capita water consumption doubling. During 2000 and 2004, China's gross water resources fell 13 percent while the per-capita amount dropped from 2,194 cubic meters to 1,856 cubic meters, down 15 percent.

  7. Expression of recombinant human lysozyme in transgenic chicken promotes the growth of Bifidobacterium in the intestine and improves postnatal growth of chicken


    Wang, Hai; Wu, Hongping; Wang, Kejun; Cao, Zhichen; Yu, Kun; Lian, Ling; Lian, Zhengxing


    Lysozyme is one kind of antimicrobial proteins and often used as feed additive which can defend against pathogenic bacteria and enhance immune function of animals. In this study, we have injected the lentiviral vector expressing recombinant human lysozyme (rhLZ) gene into the blastoderm of chicken embryo to investigate the effect of recombinant human lysozyme on postnatal intestinal microbiota distribution and growth performance of chicken. Successfully, we generated 194 transgenic chickens i...

  8. Manganese Abundances In Three Metal-poor Stars Using Improved log(gf) Data For Mn I And Mn II Lines (United States)

    Lawler, James E.; Sobeck, J. S.; Den Hartog, E. A.; Sneden, C.; Cowan, J. J.; Truran, J. W.


    We present accurate Mn abundances for three very metal-poor stars using new log(gf) measurements [Den Hartog et al. 2011] for transitions of Mn I and Mn II spanning a wavelength range from 2300 to 6050 Å. The three metal-poor ([Fe/H] Hartog, E A, Lawler J E, Sobeck J S, Sneden C, and Cowan J J 2011, ApJS 194, 35

  9. Deep inelastic reactions and isomers in neutron-rich nuclei across the perimeter of the A = 180-190 deformed region

    Directory of Open Access Journals (Sweden)

    Dracoulis G.D.


    Full Text Available Recent results on high-spin isomers populated in deep-inelastic reactions in the transitional tungsten-osmium region are outlined with a focus on 190Os, 192Os and 194Os. As well as the characterization of several two-quasinutron isomers, the 12+ and 20+ isomers in 192Os are interpreted as manifestations of maximal rotation alignment within the neutron i13/2 and possibly proton h11/2 shells at oblate deformation.

  10. Effect of feed supplement on Milk Production, Fat % Total Serum Protein and Minerals in Lactating Buffalo

    Directory of Open Access Journals (Sweden)

    R.K. Verma


    Full Text Available A study was carried out to see the effect of feed supplement “Khurak” on milk yielding buffalo. The buffaloes were divided in two group. One group was offered “Khurak” as feed supplement for 7 days. Significant increase was observed in milk production, Total serum protein and calcium in khurak supplemented group (Treatment group. [Vet. World 2009; 2(5.000: 193-194

  11. Brian R. Billman and Gary M. Feinman, editors, Settlement Pattern Studies in the Americas: Fifty Years Since Viru, Smithsonian Institution Press. Washington D.C.


    David L. Browman


    The most significant historical information in this volume is the short (3 pages) piece by Gordon R. Wllley entitled "The Viru Valley Project and Settlement Archaeology: Some Reminiscences and Con­temporary Comments." These remarks add to Willey's original background notes in his seminal 1953 publication, as well as his own retrospective look at the program in a chapter in his 1974 volume. Wllley notes that when he started out in 194...

  12. Erosion Control at TRESTLE. An Engineering Study, CE 551. (United States)


    sulfamate- formaldehyde resins. Il_ *t’ * J194 Synthetic Resn (ont °d) 31. Ethocel. 4 32. Methylol ureas and melamine . The following are methods utilired for...J149 Dispersants include phosphates, sulfonates , and versanates. The chemical agents, in breaking down aggregates, increases the fluidity of a soil...are water-soluble however. 25. Polyvinyl acetate - Same results as shellac (item 22). 26. Resorcinol- formaldehyde - Gives some strength to sand but

  13. Mass Spectral Library, NIST '02 With Windows 2.0 Software (United States)

    SRD 1A NIST/EPA/NIH Mass Spectral Library, NIST '02 With Windows 2.0 Software (PC database for purchase)   Available with full-featured NIST MS Search Program for Windows integrated tools, the NIST '98 is a fully evaluated collection of electron-ionization mass spectra. (147,198 Compounds with Spectra; 147,194 Chemical Structures; 174,948 Spectra )

  14. Improved method for extraction and detection of Helicobacter pylori DNA in formalin-fixed paraffin embedded gastric biopsies using laser micro-dissection

    Directory of Open Access Journals (Sweden)

    María Fernanda Loayza


    • The use of thin purification columns with 35 μL of elution buffer. The mean of DNA concentration obtained from 25 LM cut sections was 1.94± 0 .16 ng/μL, and it was efficiently amplified with qPCR in a Bio Rad iCycler instrument. The LM can improve the sample selection and DNA extraction for molecular analysis of H. pylori associated with human gastric epithelium.

  15. Announcement by the Internal Transport Service

    CERN Multimedia


    The Shipping Service requests all users of wooden pallets, freight containers and lids that are no longer in use to contact the Internal Transport Service of the GS department (George Truelove), which is responsible for collecting and returning them to the Goods Reception Service in Buildings 904 and 194. Please also contact Mr. Truelove if you receive an order that is not meant for you. Internal Transport Service

  16. 精神的健康に対する対人ストレッサーと対人ストレスコーピングの効果


    谷口, 弘一


    This study examined the effects of interpersonal stressors and interpersonal stress coping on mental health among adolescents. The respondents were 446 college students (144 males, 301 females, and 1 unidentified) with a mean age of 19.4 years. They completed the Scale of Interpersonal Stressors (consists of interpersonal conflict, interpersonal blunders, and interpersonal friction), the Interpersonal Stress-Coping Inventory (consists of positive relationship-oriented coping, negative relatio...

  17. Sinopec and COSCO Sign Strategic Partnership Agreement

    Institute of Scientific and Technical Information of China (English)


    @@ Sinopec and China Ocean Shipping (Group)Company (COSCO), the country's biggest shipping company, signed a framework cooperation agreement on June 18 in Beijing, under which COSCO would provide quality crude oil transport from the current 1.94 million deadweight tons. The ambitious plan was made to chter to COSCO's establishment of a long-term strategic partnership for cooperation with Sinopec, China's leading producer and supplier of petroleum products.

  18. Single-Photon Nonlinear Optics in Integrated Hollow-Core Waveguides (United States)


    for achieving the effective EIT as well as other nonlinear optics phenomena that rely on large optical depth. Here, we introduced a technique to...there is an interesting threshold phenomena with the increase of 194 195 signal power and after this threshold, the efficiency of idler generation...34, Optics Letters, 21, 1936-38, (1996). 27. V. Bali , D. A. Braje, P. Kolchin, G. Y. Yin, and S. E. Harris, “Generation of Paired Photons with

  19. Hepatitis

    Institute of Scientific and Technical Information of China (English)


    2005226 Characteristics of peripheral blood T lymphocyte subsets in hepatitis B patients. FAN Zhen-ping(范振平),et al. Center Bio Ther, Instit Infect Dis, 302 Hosp Chin PLA, Beijing 100039. World Chin J Digestol, 2005;13(2): 194-197. Objective: To characterize the T-lymphocyte subsets in peripheral blood of patients with acute and chronic hepatitis B, and to explore their relations with the disease state. Methods: Peripheral blood

  20. Decentralized Riemannian Particle Filtering with Applications to Multi-Agent Localization (United States)


    estimation scenarios. In 2003, Zhe Chen authored a technical report [63] where he described the works of Kulhavy. Chen went on to further suggest that the...Conference on Pattern Recognition (ICPR), volume 1. 2006. 63. Chen, Zhe . Bayesian Filtering: From Kalman Filters to Particle Filters and Beyond...Stochastic Models Estimation and Control, II. Academic Press, Inc., Orlando, Florida 32887, 1982. 194. van der Merwe, Rudolph and Eric Wang . “Sigma