WorldWideScience

Sample records for astatine 191

  1. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production.

  2. 19 CFR 191.191 - Purpose.

    Science.gov (United States)

    2010-04-01

    ..., including Customs brokers, may participate after being certified by Customs. Participation in the program is... 19 Customs Duties 2 2010-04-01 2010-04-01 false Purpose. 191.191 Section 191.191 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE...

  3. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  4. Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Jakobsson, U., E-mail: ulrjak@kth.se; Cederwall, B. [KTH, The Division of Nuclear Physics, AlbaNova University Center, SE-10691 Stockholm (Sweden); Uusitalo, J.; Auranen, K.; Badran, H.; Cox, D. M.; Grahn, T.; Greenlees, P. T.; Julin, R.; Juutinen, S.; Herzáň, A.; Konki, J.; Leino, M.; Mallaburn, M.; Pakarinen, J.; Papadakis, P.; Partanen, J.; Rahkila, P.; Sandzelius, M.; Sarén, J. [University of Jyvaskyla, Department of Physics, P.O. Box 35, FI-40014 University of Jyvaskyla (Finland); and others

    2015-10-15

    Low-lying states in neutron-deficient astatine and francium nuclei have been studied by means of in-beam and delayed spectroscopy. The 13/2{sup +} state has been observed in francium nuclei with a similar down-sloping trend as in neighbouring astatine and bismuth isotopes, as a function of decreasing neutron number. A systematic trend can also now be seen for the 1/2{sup +} state both in astatine and francium nuclei, where the level energy decreases steeply as a function of neutron number when moving further away from the neutron shell closure. This trend is very similar between astatine nuclei and their francium isotones. Moreover, shape coexistence has been observed between the 13/2{sup +} state and the spherical 9/2{sup −} ground state in {sup 203}Fr and {sup 205}Fr.

  5. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom

    2015-01-01

    and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting......To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...

  6. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    NARCIS (Netherlands)

    Rothe, S.; Andreyev, A. N.; Antalic, S.; Borschevsky, A.; Capponi, L.; Cocolios, T. E.; De Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.; Kaldor, U.; Kudryavtsev, Yuri; Koester, U.; Lane, J. F. W.; Lassen, J.; Liberati, V.; Lynch, K. M.; Marsh, B. A.; Nishio, K.; Pauwels, D.; Pershina, V.; Popescu, L.; Procter, T. J.; Radulov, D.; Raeder, S.; Rajabali, M. M.; Rapisarda, E.; Rossel, R. E.; Sandhu, K.; Seliverstov, M. D.; Sjoedin, A. M.; Van den Bergh, P.; Van Duppen, P.; Venhart, M.; Wakabayashi, Y.; Wendt, K. D. A.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviou

  7. 49 CFR 191.1 - Scope.

    Science.gov (United States)

    2010-10-01

    ..., operation, and maintenance under 49 CFR 190.9. (3) Pipelines on the Outer Continental Shelf upstream of the... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 191.1 Section 191.1 Transportation Other...; ANNUAL REPORTS, INCIDENT REPORTS, AND SAFETY-RELATED CONDITION REPORTS § 191.1 Scope. (a) This...

  8. 32 CFR 191.5 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 191.5 Section 191.5 National... DOD CIVILIAN EQUAL EMPLOYMENT OPPORTUNITY (EEO) PROGRAM § 191.5 Responsibilities. (a) The Assistant... responsibilities. (7) Ensure fair, impartial, and timely investigation and resolution of complaints...

  9. 19 CFR 191.163 - Documentation.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Documentation. 191.163 Section 191.163 Customs... or Specifications § 191.163 Documentation. (a) Entry. Customs Form 7551 shall be used to claim drawback under this subpart. (b) Documentation. The drawback entry for unmerchantable merchandise shall...

  10. 19 CFR 191.13 - Packaging materials.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Packaging materials. 191.13 Section 191.13 Customs... (CONTINUED) DRAWBACK General Provisions § 191.13 Packaging materials. (a) Imported packaging material... packaging material when used to package or repackage merchandise or articles exported or destroyed...

  11. 32 CFR 191.10 - Effective date.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Effective date. 191.10 Section 191.10 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS THE DOD CIVILIAN EQUAL EMPLOYMENT OPPORTUNITY (EEO) PROGRAM § 191.10 Effective date. This part...

  12. 40 CFR 191.03 - Standards.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Standards. 191.03 Section 191.03... ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR MANAGEMENT AND DISPOSAL OF SPENT NUCLEAR FUEL, HIGH-LEVEL AND TRANSURANIC RADIOACTIVE WASTES Environmental Standards for Management and Storage § 191.03 Standards....

  13. 32 CFR 191.4 - Policy.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Policy. 191.4 Section 191.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS THE DOD CIVILIAN EQUAL EMPLOYMENT OPPORTUNITY (EEO) PROGRAM § 191.4 Policy. It is DoD Policy to: (a)...

  14. Dicty_cDB: SLA191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLA191 (Link to dictyBase) - - - Contig-U16523-1 SLA191Z (Link... to Original site) - - SLA191Z 561 - - - - Show SLA191 Library SL (Link to library) Clone ID SLA191 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLA1-D/SLA191Q.Seq.d/ Representative seq. ID SLA19...1Z (Link to Original site) Representative DNA sequence >SLA191 (SLA191Q) /CSM/SL/SLA1-D/SLA191Q.Seq.d/ XXXXX...TATTTACCAATTGTTAAAACTCATTTTATTTTATTTTTATCTCTTACATATCTCTTT TTCTATTAATAATAAAAATAATAATATTACA sequence update 1997. 5.16 Transla

  15. Dicty_cDB: VSI191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VS (Link to library) VSI191 (Link to dictyBase) - - - Contig-U15128-1 VSI191P (Link to Original site) VSI...191P (Link to Original site) Representative DNA sequence >VSI191 (VSI191Q) /CSM/VS/VSI1-D/VSI1...ame A: rvrkwvvleqrqskelpnsslrsitqdlpmtstltrxlatnsprshqnv*etrllvsvpi **DVLLMVQSVVFLTNYKKKKEKREITTFHKNQPSKPTKLKSI...nhpt nprr*pkeiqqkhqkikq Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value VSI191 (VSI...191F 450 VSI191Z 408 VSI191P 858 - - Show VSI191 Library VS (Link to library) Clone ID VSI

  16. 21 CFR 155.191 - Tomato concentrates.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Tomato concentrates. 155.191 Section 155.191 Food... Tomato concentrates. (a) Identity—(1) Definition. Tomato concentrates are the class of foods each of... tomato ingredients: (i) The liquid obtained from mature tomatoes of the red or reddish...

  17. 40 CFR 436.191 - Specialized definitions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Specialized definitions. 436.191 Section 436.191 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS MINERAL MINING AND PROCESSING POINT SOURCE CATEGORY Frasch Sulfur Subcategory §...

  18. 27 CFR 20.191 - Bulk articles.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bulk articles. 20.191... Users of Specially Denatured Spirits Operations by Users § 20.191 Bulk articles. Users who convey articles in containers exceeding one gallon may provide the recipient with a photocopy of subpart G of...

  19. Dicty_cDB: CHS191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHS191 (Link to dictyBase) - - - Contig-U11946-1 CHS191P (Link to Original site) CHS19...1F 630 CHS191Z 689 CHS191P 1299 - - Show CHS191 Library CH (Link to library) Clone ID CHS19...e URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CH/CHS1-D/CHS191Q.Seq.d/ Representative seq. ID CHS19...1P (Link to Original site) Representative DNA sequence >CHS191 (CHS191Q) /CSM/CH/CHS1-D/CHS19...roducing significant alignments: (bits) Value CHS191 (CHS191Q) /CSM/CH/CHS1-D/CHS191Q.Seq.d/ 1130 0.0 VHK578

  20. Dicty_cDB: VFL191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VF (Link to library) VFL191 (Link to dictyBase) - - - Contig-U12252-1 VFL191P (Link to Original site) VFL1...91F 209 VFL191Z 442 VFL191P 631 - - Show VFL191 Library VF (Link to library) Clone ID VFL1... URL http://dictycdb.biol.tsukuba.ac.jp/CSM/VF/VFL1-D/VFL191Q.Seq.d/ Representative seq. ID VFL1...91P (Link to Original site) Representative DNA sequence >VFL191 (VFL191Q) /CSM/VF/VFL1-D/VFL1...Sequences producing significant alignments: (bits) Value VFL191 (VFL191Q) /CSM/VF/VFL1-D/VFL191Q.Seq.d/ 797

  1. Dicty_cDB: AFM191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AF (Link to library) AFM191 (Link to dictyBase) - - - - AFM191P (Link to Original site) AFM191F 623 AFM...191Z 747 AFM191P 1350 - - Show AFM191 Library AF (Link to library) Clone ID AFM191 (Link... to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/AF/AFM...1-D/AFM191Q.Seq.d/ Representative seq. ID AFM191P (Link to... Original site) Representative DNA sequence >AFM191 (AFM191Q) /CSM/AF/AFM1-D/AFM191Q.Seq.d/ ATTTTCTATTTTCTTT

  2. Dicty_cDB: VHF191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VH (Link to library) VHF191 (Link to dictyBase) - - - Contig-U16260-1 - (Link to Original site) VHF...191F 400 - - - - - - Show VHF191 Library VH (Link to library) Clone ID VHF191 (Link to dicty...iol.tsukuba.ac.jp/CSM/VH/VHF1-D/VHF191Q.Seq.d/ Representative seq. ID - (Link to ...Original site) Representative DNA sequence >VHF191 (VHF191Q) /CSM/VH/VHF1-D/VHF191Q.Seq.d/ AACTCTCGAGTGCAAAA...DHGKTTLSDSLIQRAGIIADKV SGDMRYMSCRADEQERGITIKSSSVSLHFXMPKEDKLPAGCTSHEFLINLIDSPGHVDFS SEVTAALRV--- Translated

  3. 40 CFR 191.02 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... TRANSURANIC RADIOACTIVE WASTES Environmental Standards for Management and Storage § 191.02 Definitions. Unless... in accordance with 10 CFR Part 61. (j) Radioactive waste, as used in this part, means the...

  4. 40 CFR 191.24 - Disposal standards.

    Science.gov (United States)

    2010-07-01

    ..., HIGH-LEVEL AND TRANSURANIC RADIOACTIVE WASTES Environmental Standards for Ground-Water Protection § 191... of drinking water, in the accessible environment, to exceed the limits specified in 40 CFR part...

  5. 40 CFR 191.22 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... TRANSURANIC RADIOACTIVE WASTES Environmental Standards for Ground-Water Protection § 191.22 Definitions... determined by use of the method specified in 40 CFR part 136. Underground source of drinking water means...

  6. 40 CFR 191.14 - Assurance requirements.

    Science.gov (United States)

    2010-07-01

    ..., HIGH-LEVEL AND TRANSURANIC RADIOACTIVE WASTES Environmental Standards for Disposal § 191.14 Assurance... Commission (see 10 CFR Part 60 for comparable provisions applicable to facilities regulated by the...

  7. 19 CFR 191.141 - Drawback allowance.

    Science.gov (United States)

    2010-04-01

    ... TREASURY (CONTINUED) DRAWBACK Foreign-Built Jet Aircraft Engines Processed in the United States § 191.141... exportation of jet aircraft engines manufactured or produced abroad that have been overhauled,...

  8. 40 CFR 98.191 - Reporting threshold.

    Science.gov (United States)

    2010-07-01

    ...) MANDATORY GREENHOUSE GAS REPORTING Lime Manufacturing § 98.191 Reporting threshold. You must report GHG emissions under this subpart if your facility is a lime manufacturing plant as defined in § 98.190 and...

  9. Laser photodetachment of radioactive ions: towards the determination of the electronegativity of astatine

    CERN Multimedia

    Rothe, Sebastian; Welander, Jakob Emanuel; Chrysalidis, Katerina; Day Goodacre, Thomas; Fedosseev, Valentine; Fiotakis, Spyridon; Forstner, Oliver; Heinke, Reinhard Matthias; Johnston, Karl; Kron, Tobias; Koester, Ulli; Liu, Yuan; Marsh, Bruce; Ringvall Moberg, Annie; Rossel, Ralf Erik; Seiffert, Christoph; Studer, Dominik; Wendt, Klaus; Hanstorp, Dag

    2017-01-01

    Negatively charged ions are mainly stabilized through the electron correlation effect. A measure of the stability of a negative ion is the electron affinity, which the energy gain by attaching an electron to a neutral atom. This fundamental quantity is, due to the almost general lack of bound excited states, the only atomic property that can be determined with high accuracy for negative ions. We will present the results of the first laser photodetachment studies of radioactive negative ions at CERN-ISOLDE. The photodetachment threshold for the radiogenic iodine isotope 128I was measured successfully, demonstrating the performance of the upgraded GANDALPH experimental beam line. The first detection of photo-detached astatine atoms marks a milestone towards the determination of the EA of this radioactive element.

  10. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron affinity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photo-detachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral line width of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in off-line tests by the clear observation of the photo-detachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148.

  11. 19 CFR 191.143 - Drawback entry.

    Science.gov (United States)

    2010-04-01

    ... (CONTINUED) DRAWBACK Foreign-Built Jet Aircraft Engines Processed in the United States § 191.143 Drawback entry. (a) Filing of entry. Drawback entries covering these foreign-built jet aircraft engines shall be filed on Customs Form 7551, modified to show that the entry covers jet aircraft engines processed...

  12. 19 CFR 191.44 - Destruction under Customs supervision.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Destruction under Customs supervision. 191.44 Section 191.44 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Rejected Merchandise § 191.44 Destruction under...

  13. 19 CFR 191.164 - Return to Customs custody.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Return to Customs custody. 191.164 Section 191.164 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... to Sample or Specifications § 191.164 Return to Customs custody. There is no time limit for...

  14. 19 CFR 191.25 - Destruction under Customs supervision.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Destruction under Customs supervision. 191.25 Section 191.25 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Manufacturing Drawback § 191.25 Destruction under...

  15. 19 CFR 191.8 - Specific manufacturing drawback ruling.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Specific manufacturing drawback ruling. 191.8...; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK General Provisions § 191.8 Specific manufacturing drawback ruling. (a) Applicant. Unless operating under a general manufacturing drawback ruling (see § 191.7),...

  16. Ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and ionic radii of element Uus (Z = 117) and astatine.

    Science.gov (United States)

    Chang, Zhiwei; Li, Jiguang; Dong, Chenzhong

    2010-12-30

    Multiconfiguration Dirac-Fock (MCDF) method was employed to calculate the first five ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and radii for the element Uus and its homologue At. Main valence correlation effects were taken into account. The Breit interaction and QED effects were also estimated. The uncertainties of calculated IPs, EAs, and IR for Uus and At were reduced through an extrapolation procedure. The good consistency with available experimental and other theoretical values demonstrates the validity of the present results. These theoretical data therefore can be used to predict some unknown physicochemical properties of element Uus, Astatine, and their compounds.

  17. 19 CFR 191.175 - Drawback claimant; maintenance of records.

    Science.gov (United States)

    2010-04-01

    ...; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Substitution of Finished Petroleum Derivatives § 191.175... origin (imported, manufactured, substituted, or any combination thereof), so designated on a...

  18. Superdeformation studies in {sup 191}Hg

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, M.P.; Janssens, R.V.F.; Crowell, B. [and others

    1995-08-01

    Superdeformation in the A {approximately} 190 region was first observed in {sup 191}Hg from an experiment performed at ATLAS using the Argonne Notre Dame {gamma}-ray facility. We recently revisited the study of superdeformation in this nucleus using Gammasphere and the {sup 160}Gd({sup 36}S,5n) and {sup 174}Yb({sup 22}Ne,5n) reactions at 172 and 120 MeV in order to populate and measure states in the second well. The goal of the experiment was to identify new bands in the data, and thus allow us to gain understanding on the relative placement of single particle orbitals near the N = 112 SD shell gap. From an analysis of the data, the three previously identified SD bands were extended, and their feeding into the yrast states delineated. Two new SD bands were observed and preliminary evidence for a third new band was obtained as well.

  19. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  20. 19 CFR 191.26 - Recordkeeping for manufacturing drawback.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Recordkeeping for manufacturing drawback. 191.26...; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Manufacturing Drawback § 191.26 Recordkeeping for manufacturing drawback. (a) Direct identification manufacturing—(1) Records required. Each manufacturer...

  1. 19 CFR 191.152 - Merchandise released from Customs custody.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Merchandise released from Customs custody. 191.152 Section 191.152 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Merchandise Exported From Continuous Customs Custody §...

  2. 19 CFR 191.37 - Destruction under Customs supervision.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Destruction under Customs supervision. 191.37 Section 191.37 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Customs supervision. A claimant may destroy merchandise and obtain unused merchandise drawback...

  3. 19 CFR 191.153 - Continuous Customs custody.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Continuous Customs custody. 191.153 Section 191.153 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Merchandise Exported From Continuous Customs Custody §...

  4. 40 CFR 191.15 - Individual protection requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Individual protection requirements. 191.15 Section 191.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION... Individual protection requirements. (a) Disposal systems for waste and any associated radioactive...

  5. 19 CFR 191.6 - Authority to sign drawback documents.

    Science.gov (United States)

    2010-04-01

    ... or her own behalf; or (6) A licensed Customs broker with a power of attorney. (b) The following... 19 Customs Duties 2 2010-04-01 2010-04-01 false Authority to sign drawback documents. 191.6 Section 191.6 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND...

  6. 49 CFR 192.191 - Design pressure of plastic fittings.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Design pressure of plastic fittings. 192.191... Components § 192.191 Design pressure of plastic fittings. (a) Thermosetting fittings for plastic pipe must conform to ASTM D 2517, (incorporated by reference, see § 192.7). (b) Thermoplastic fittings for...

  7. 19 CFR 191.7 - General manufacturing drawback ruling.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false General manufacturing drawback ruling. 191.7...; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK General Provisions § 191.7 General manufacturing drawback ruling. (a) Purpose; eligibility. General manufacturing drawback rulings are designed to...

  8. Expression and purification of a novel ZNF191 zinc finger protein——ZNF191 protein and its truncated zinc finger region ZNF191 (243—368)

    Institute of Scientific and Technical Information of China (English)

    刘玉奇; 余龙; 余文浩; 施少林; 孙炳耘; 吴国俊; 黄仲贤

    1999-01-01

    ZNF191 is a new zine finger gene whieh has a 1107 bp open reading frame (ORF) and eneodes a 368 amino avid protein including a putative DNA-binding domain of four Cys2 His2 zine finger motifs at its C-terminal region. The ZNF191 cDNA is loeated in the chromosome 18q12.1 region where it is known that a variety of hereditary diseases are related to. Probably, this protein has potential function of stimulating the gene franscription. In order to examine the function and structure of ZNF191 protein, the ORF of ZNF191 and its zine finger region ZNF191(243--368) genes were inserted into PTSA-18 expression vector by PCR amplification, then the constructed genes were expressed in the PTSA-18/B121 (DE3) system. The two proteins were purified by DEAE-52, CM-23 and Heparin-Sepharose 4B columns. The pooled proteins showed a single band as assayed by Coomasie Brillian Blue Staining of an SDS/polyacryamide gel.

  9. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  10. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  11. 7 CFR 1.191 - Net worth exhibit.

    Science.gov (United States)

    2010-01-01

    ... Equal Access to Justice Act in Proceedings Before the Department Information Required from Applicants § 1.191 Net worth exhibit. (a) An applicant, except a qualified tax-exempt organization or...

  12. 16 CFR 1.91 - Authority and purpose.

    Science.gov (United States)

    2010-01-01

    ... PROCEDURES Economic Surveys, Investigations and Reports § 1.91 Authority and purpose. General and special economic surveys, investigations, and reports are made by the Bureau of Economics under the authority...

  13. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  14. MiR-191 Regulates Primary Human Fibroblast Proliferation and Directly Targets Multiple Oncogenes.

    Directory of Open Access Journals (Sweden)

    Damon Polioudakis

    Full Text Available miRNAs play a central role in numerous pathologies including multiple cancer types. miR-191 has predominantly been studied as an oncogene, but the role of miR-191 in the proliferation of primary cells is not well characterized, and the miR-191 targetome has not been experimentally profiled. Here we utilized RNA induced silencing complex immunoprecipitations as well as gene expression profiling to construct a genome wide miR-191 target profile. We show that miR-191 represses proliferation in primary human fibroblasts, identify multiple proto-oncogenes as novel miR-191 targets, including CDK9, NOTCH2, and RPS6KA3, and present evidence that miR-191 extensively mediates target expression through coding sequence (CDS pairing. Our results provide a comprehensive genome wide miR-191 target profile, and demonstrate miR-191's regulation of primary human fibroblast proliferation.

  15. MiR-191 Regulates Primary Human Fibroblast Proliferation and Directly Targets Multiple Oncogenes.

    Science.gov (United States)

    Polioudakis, Damon; Abell, Nathan S; Iyer, Vishwanath R

    2015-01-01

    miRNAs play a central role in numerous pathologies including multiple cancer types. miR-191 has predominantly been studied as an oncogene, but the role of miR-191 in the proliferation of primary cells is not well characterized, and the miR-191 targetome has not been experimentally profiled. Here we utilized RNA induced silencing complex immunoprecipitations as well as gene expression profiling to construct a genome wide miR-191 target profile. We show that miR-191 represses proliferation in primary human fibroblasts, identify multiple proto-oncogenes as novel miR-191 targets, including CDK9, NOTCH2, and RPS6KA3, and present evidence that miR-191 extensively mediates target expression through coding sequence (CDS) pairing. Our results provide a comprehensive genome wide miR-191 target profile, and demonstrate miR-191's regulation of primary human fibroblast proliferation.

  16. Ferimentos cervicais: análise retrospectiva de 191 casos Neck injuries: retrospective analysis of 191

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Von Bahten

    2003-10-01

    Full Text Available OBJETIVOS: Analisar a epidemiologia e a conduta nos ferimentos cervicais. MÉTODO: Foram analisados 487.128 prontuários de pacientes que ingressaram no Serviço de Emergência do Hospital Universitário Cajuru no período de 01/1996 a 06/2001. Destes, selecionaram-se 378 pacientes com ferimentos cervicais. Foram excluídos 153 que apresentavam lesões associadas e 14 por óbito no atendimento inicial. O estudo foi feito , assim, em 191 pacientes com les��es cervicais exclusivas. Avaliou-se a localização da ferida, o mecanismo de trauma, o comprometimento do platisma, sinais e sintomas, a hora de admissão e a conduta empregada. RESULTADOS: Cento e sessenta e quatro (86% pacientes eram masculinos. A média de idade foi de 28 anos (10-72. Noventa (47% ferimentos foram por arma de fogo (FAF e 88 (46% por arma branca (FAB. O principal horário de admissão foi entre 20 e 04 horas. Quanto à localização, 53% das lesões foram à esquerda, 45% à direita e 2% medianos; 36% em zona I, 55% em zona II e 9% em zona III. Em 101 o ferimento penetrou o platisma: cinqüenta e um (50% apresentaram sinais e sintomas clínicos e receberam conduta operatória. As lesões vasculares foram as mais encontradas (20. Houve 24 (47% cervicotomias não-terapêuticas. O tratamento conservador foi empregado em 41 (45% casos de acordo com os exames físico e complementares. CONCLUSÕES: Homens jovens são mais acometidos quanto aos ferimentos cervicais. Estes ocorrem mais freqüentemente na zona II, e a incidência dos FAF e FAB foi equivalente. É adequado um manejo mais seletivo em relação aos ferimentos cervicais, devendo o manejo da zona II adequar-se à disposição de recursos dos serviços de trauma.BACKGROUND: The study proposes to assess the demographics and management of neck injuries. METHODS: A retrospective review of 487.128 emergency department medical records from 01/1996 to 06/2001 was conducted. Out of the 378 patients selected for the analysis

  17. 22 CFR 191.22 - Administration of benefits.

    Science.gov (United States)

    2010-04-01

    ... § 191.22 Administration of benefits. (a) An eligible person, who desires medical or health care under... shall include a determination as to the necessity and reasonableness of medical or health care. (c) The... authorized care from any licensed facility or health care provider of their choice approved by the Office....

  18. 19 CFR 191.192 - Certification for compliance program.

    Science.gov (United States)

    2010-04-01

    ... program. (c) Broker certification. A Customs broker may be certified as a participant in the drawback compliance program only on behalf of a given claimant (see § 191.194(b)). To do so, a Customs broker who is... 19 Customs Duties 2 2010-04-01 2010-04-01 false Certification for compliance program....

  19. 42 CFR 84.191 - Chemical cartridge respirators; required components.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Chemical cartridge respirators; required components... Chemical Cartridge Respirators § 84.191 Chemical cartridge respirators; required components. (a) Each chemical cartridge respirator described in § 84.190 shall, where its design requires, contain the...

  20. Estrabismo sensorial: estudo de 191 casos Sensorial strabismus: a study of 191 cases

    Directory of Open Access Journals (Sweden)

    Bráulio Folco Telles de Oliveira

    2006-02-01

    Full Text Available OBJETIVO: Avaliar os prontuários dos pacientes com estrabismo sensorial em aspectos variados, como etiologia, tipo e medida do desvio, correlação do tipo do desvio com a idade de aparecimento da doença de base, e resultado cirúrgico dos casos operados. MÉTODOS: Avaliação dos prontuários médicos dos pacientes com estrabismo sensorial atendidos no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - USP - no setor de Motilidade Ocular Extrínseca, no período de setembro de 1990 a julho de 2002. RESULTADOS: Foram avaliados 84 pacientes masculinos e 107 femininos; o diagnóstico mais freqüente para baixa visual foi coriorretinite atrófica em 49 casos. Oitenta e sete pacientes tinham exotropia e 97 tinham esotropia. Oitenta e dois pacientes tiveram cirurgia indicada, e 50 foram operados. Em 42 deles, foi constatado sucesso cirúrgico de 90,5% (desvio longe e perto menor ou igual a 15 dioptrias prismáticas. CONCLUSÕES: O bom resultado cirúrgico observado neste e em outros estudos reforça a necessidade da correção cirúrgica nesses casos.PURPOSE: To evaluate the charts of patients with sensorial strabismus regarding range of different aspects, such as etiology, the type and the amount of deviation, relationship between the type of deviation and the patient's age when the disease occurred and the surgical outcome. METHODS: A retrospective analysis of data charts of 191 patients seen at the section of Ophthalmology at the University of São Paulo, from September 1990 to July 2002. RESULTS: There were 84 male and 107 female patients. The most frequent diagnosis responsible for low vision in the squinted eye was atrophic chorioretinitis in 49 patients. Eighty-seven were exotropes and 97 were esotropes. Fifty patients were operated on, but 8 of them were lost to follow-up. In 90.5% the surgical outcome was successful: less than 15 prismatic diopters of hyper or undercorrection after surgery. CONCLUSIONS: The

  1. 19 CFR 191.184 - Merchandise transferred from continuous Customs custody.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Merchandise transferred from continuous Customs custody. 191.184 Section 191.184 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... From Customs Territory § 191.184 Merchandise transferred from continuous Customs custody. (a)...

  2. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  3. Raman spectroscopy study of zinc finger ZNF191(243-368)

    Institute of Scientific and Technical Information of China (English)

    HUANG Zhongxian; ZHANG Hailiang; YAO Wenhua; LIU Yuqi; ZHOU Jing; TANG Liming

    2003-01-01

    The structure of ZNF191(243-368), the zinc finger region protein of zinc finger protein ZNF191, and its structural change upon thermal and EDTA-induced denaturation were investigated by the Raman spectroscopy. It was demonstrated that the coordination between Zn2+ and His/Cys in ZNF191(243-368) is the essential factor to the stability of zinc finger, which plays an important role in maintaining the hydrophobic core and the secondary structure in zinc finger, and the Raman spectroscopy is a powerful tool for investigating the structure of ZNF191(243-368).

  4. 49 CFR 191.13 - Distribution systems reporting transmission pipelines; transmission or gathering systems...

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Distribution systems reporting transmission pipelines; transmission or gathering systems reporting distribution pipelines. 191.13 Section 191.13... Distribution systems reporting transmission pipelines; transmission or gathering systems reporting...

  5. 19 CFR 191.71 - Drawback on articles destroyed under Customs supervision.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Drawback on articles destroyed under Customs supervision. 191.71 Section 191.71 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... articles destroyed under Customs supervision. (a) Procedure. At least 7 working days before the...

  6. 19 CFR 191.1 - Authority of the Commissioner of Customs.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Authority of the Commissioner of Customs. 191.1 Section 191.1 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Customs. Pursuant to Treasury Department Order No. 165, Revised (T.D. 53654, 19 FR 7241), as amended,...

  7. 50 CFR 216.191 - Designation of Offshore Biologically Important Marine Mammal Areas.

    Science.gov (United States)

    2010-10-01

    ...) Detailed information on the biology of marine mammals within the area, including estimated population size... Important Marine Mammal Areas. 216.191 Section 216.191 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE...

  8. 34 CFR 300.191 - Provisions for services under a by-pass.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Provisions for services under a by-pass. 300.191... EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility By-Pass for Children in Private Schools § 300.191 Provisions for services under a by-pass. (a) Before implementing a by-pass, the Secretary consults...

  9. Transcriptional Fingerprint of Hypomyelination in Zfp191null and Shiverer (Mbpshi) Mice.

    Science.gov (United States)

    Aaker, Joshua D; Elbaz, Benayahu; Wu, Yuwen; Looney, Timothy J; Zhang, Li; Lahn, Bruce T; Popko, Brian

    2016-10-01

    The transcriptional program that controls oligodendrocyte maturation and central nervous system (CNS) myelination has not been fully characterized. In this study, we use high-throughput RNA sequencing to analyze how the loss of a key transcription factor, zinc finger protein 191 (ZFP191), results in oligodendrocyte development abnormalities and CNS hypomyelination. Using a previously described mutant mouse that is deficient in ZFP191 protein expression (Zfp191(null)), we demonstrate that key transcripts are reduced in the whole brain as well as within oligodendrocyte lineage cells cultured in vitro To determine whether the loss of myelin seen in Zfp191(null) mice contributes indirectly to these perturbations, we also examined the transcriptome of a well-characterized mouse model of hypomyelination, in which the myelin structural protein myelin basic protein (MBP) is deficient. Interestingly, Mbp(shi) (shiverer) mice had far fewer transcripts perturbed with the loss of myelin alone. This study demonstrates that the loss of ZFP191 disrupts expression of genes involved in oligodendrocyte maturation and myelination, largely independent from the loss of myelin. Nevertheless, hypomyelination in both mouse mutants results in the perturbation of lipid synthesis pathways, suggesting that oligodendrocytes have a feedback system that allows them to regulate myelin lipid synthesis depending on their myelinating state. The data presented are of potential clinical relevance as the human orthologs of the Zfp191 and MBP genes reside on a region of Chromosome 18 that is deleted in childhood leukodystrophies.

  10. Transcriptional Fingerprint of Hypomyelination in Zfp191null and Shiverer (Mbpshi Mice

    Directory of Open Access Journals (Sweden)

    Joshua D. Aaker

    2016-09-01

    Full Text Available The transcriptional program that controls oligodendrocyte maturation and central nervous system (CNS myelination has not been fully characterized. In this study, we use high-throughput RNA sequencing to analyze how the loss of a key transcription factor, zinc finger protein 191 (ZFP191, results in oligodendrocyte development abnormalities and CNS hypomyelination. Using a previously described mutant mouse that is deficient in ZFP191 protein expression (Zfp191null, we demonstrate that key transcripts are reduced in the whole brain as well as within oligodendrocyte lineage cells cultured in vitro. To determine whether the loss of myelin seen in Zfp191null mice contributes indirectly to these perturbations, we also examined the transcriptome of a well-characterized mouse model of hypomyelination, in which the myelin structural protein myelin basic protein (MBP is deficient. Interestingly, Mbpshi (shiverer mice had far fewer transcripts perturbed with the loss of myelin alone. This study demonstrates that the loss of ZFP191 disrupts expression of genes involved in oligodendrocyte maturation and myelination, largely independent from the loss of myelin. Nevertheless, hypomyelination in both mouse mutants results in the perturbation of lipid synthesis pathways, suggesting that oligodendrocytes have a feedback system that allows them to regulate myelin lipid synthesis depending on their myelinating state. The data presented are of potential clinical relevance as the human orthologs of the Zfp191 and MBP genes reside on a region of Chromosome 18 that is deleted in childhood leukodystrophies.

  11. Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin.

    Science.gov (United States)

    Pietrzak, Monika; Halicka, H Dorota; Wieczorek, Zbigniew; Wieczorek, Jolanta; Darzynkiewicz, Zbigniew

    2008-06-01

    We have investigated the ability of chlorophyllin (CHL) to interact with acridine mutagen ICR-191 (2-methoxy-6-chloro-9-(3-(2-chloroethyl)aminopropylamino)acridine) and also its ability to decrease binding of ICR-191 to DNA in a simple three-component competition system: CHL-ICR-DNA. Our data indicate a strong association of ICR-191 with CHL, stronger even than the association of ICR-191 with DNA. Calculations based on the measured affinity data show that a two- to three-fold excess of CHL reduces by about two-fold the concentration of the mutagen-DNA complex. We also exposed human leukemic HL-60 cells to ICR-191 in the absence and presence of CHL and measured the mutagen-induced DNA damage. The extent of DNA damage was assessed by analysis of histone H2AX phosphorylation. While ICR-191 induced significant increase in expression of phosphorylated H2AX (gammaH2AX), particularly in DNA replicating cells, this increase was totally abolished in the cells treated with ICR-191 in the presence of CHL.

  12. Search for entrance-channel dependence in the population of superdeformed bands in {sup 191}Hg

    Energy Technology Data Exchange (ETDEWEB)

    Soramel, F.; Khoo, T.L.; Janssens, R.V.F. [and others

    1995-08-01

    The population intensity of some SD bands in the mass 150 region were observed to depend on the mass symmetry of the entrance channel in the fusion reaction. The authors raised the possibility that the population of SD bands had a memory of the entrance channel. To check this interesting possibility, we made measurements of the population intensities of superdeformed (SD) bands in the {sup 160}Gd({sup 36}S,5n){sup 191}Hg and {sup 130}Te({sup 64}Ni,3n){sup 191}Hg reactions. To ensure that any observed effect was not due to a simple angular momentum difference in the entrance channels, we also measured the average entry points and spin distributions of normal and SD states in {sup 191}Hg in the two reactions. The entry points and spin distributions for {sup 191}Hg are the same and, indeed, so are the SD intensities in the two reactions. Hence, no entrance-channel effect is observed in the population of the SD band in {sup 191}Hg, in contrast with data for SD bands in the mass 150 regions. We suggest that the effect observed previously in the mass 150 region is due to an angular momentum effect. A letter reporting our results was submitted for publication.

  13. An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211

    Energy Technology Data Exchange (ETDEWEB)

    O’Hara, Matthew J.; Krzysko, Anthony J.; Niver, Cynthia M.; Morrison, Samuel S.; Owsley, Stanley L.; Hamlin, Donald K.; Dorman, Eric F.; Scott Wilbur, D.

    2017-04-01

    Astatine-211 (211At) is a promising cyclotron-produced radionuclide being investigated for use in targeted alpha therapy of blood borne and metastatic cancers, as well as treatment of tumor remnants after surgical resections. The isolation of trace quantities of 211At, produced within several grams of a Bi metal cyclotron target, involves a complex, multi-step procedure: (1) Bi metal dissolution in strong HNO3, (2) distillation of the HNO3 to yield Bi salts containing 211At, (3) dissolution of the salts in strong HCl, (4) solvent extraction of 211At from bismuth salts with diisopropyl ether (DIPE), and (5) back-extraction of 211At from DIPE into NaOH, leading to a purified 211At product. Step (1) has been addressed first to begin the process of automating the onerous 211At isolation process. A computer-controlled Bi target dissolution system has been designed. The system performs in-line dissolution of Bi metal from the target assembly using an enclosed target dissolution block, routing the resulting solubilized 211At/Bi mixture to the subsequent process step. The primary parameters involved in Bi metal solubilization (HNO3 concentration and influent flow rate) were optimized prior to evaluation of the system performance on replicate cyclotron irradiated targets. The results indicate that the system performs reproducibly, having nearly quantitative release of 211At from irradiated targets, with cumulative 211At recoveries that follow a sigmoidal function. The predictable nature of the 211At release profile allows the user to tune the system to meet target processing requirements.

  14. Studies of radioactive cisplatin ({sup 191}Pt) for tumour imaging and therapy

    Energy Technology Data Exchange (ETDEWEB)

    Areberg, J

    2000-01-01

    A radioactive variant of the cytostatic agent cis-dichlorodiammineplatinum(II), cisplatin, was synthesised from {sup 191}PtCl{sub 4}. The {sup 191}Pt-cisplatin was found to be a sterile product of high radionuclide, radiochemical and chemical purity. The pharmacokinetics of platinum in tumour tissue and organs at risk of fourteen patients undergoing treatment with cisplatin were studied by exchanging a small fraction of the prescribed amount of cisplatin with {sup 191}Pt-cisplatin. The uptake and retention of platinum were investigated by gamma camera measurements up to ten days after infusion of {sup 191}Pt-cisplatin. Highest concentration of platinum was found in the liver, on average 5.7 {+-} 0.5 {mu}g/g normalised to a given amount of 180 mg cisplatin. Corresponding value for the kidneys was 1.9 {+-} 0.3 {mu}g/g. Uptake of platinum in tumours was visualised in five patients with an average maximum concentration of 4.9 {+-} 1.0 {mu}g/g normalised to a given amount of 180 mg cisplatin. The data from the pharmacokinetic study was used together with data from the literature to estimate the absorbed dose and effective dose to patients receiving radioactive cisplatin. The effective doses were calculated to be 0.10 {+-} 0.02 mSv/MBq, 0.17 {+-} 0.04 mSv/MBq and 0.23 {+-} 0.05 mSv/MBq for {sup 191}Pt-, {sup 193m}Pt-, and {sup 195m}Pt-cisplatin respectively. The combined effect of the radio- and chemotoxicity from {sup 191}Pt-cisplatin was investigated both in vitro and in vivo. A cervical cancer cell line was incubated with cisplatin or {sup 191}Pt-cisplatin with various concentrations and specific activities. It was shown that the surviving fraction was smaller for cells treated with {sup 191}Pt-cisplatin than for cells treated with the same concentration of non-radioactive cisplatin. The surviving fraction decreased with increasing specific activity. Isobologram technique showed that the radio- and chemotoxicity interacted in a supra-additive (synergistic) manner. In

  15. 19 CFR 191.155 - Merchandise withdrawn from warehouse for exportation.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Merchandise withdrawn from warehouse for... Custody § 191.155 Merchandise withdrawn from warehouse for exportation. The regulations in part 18 of this... from warehouse for exportation without payment of duty shall be followed to the extent applicable....

  16. 40 CFR Appendix C to Part 191 - Guidance for Implementation of Subpart B

    Science.gov (United States)

    2010-07-01

    ... of the disposal system should not be disregarded, even if projected performance is uncertain, except... system performance. Determining compliance with § 191.13 will also involve predicting the likelihood of events and processes that may disturb the disposal system. In making these various predictions, it...

  17. Expression of symbiotic genes of Rhizobium japonicum USDA 191 in other rhizobia.

    OpenAIRE

    Appelbaum, E R; McLoughlin, T J; O'Connell, M; Chartrain, N

    1985-01-01

    A 200-megadalton plasmid was mobilized from Rhizobium japonicum USDA 191 to other Rhizobium strains either that cannot nodulate soybeans or that form Fix- nodules on certain cultivars. The symbiotic properties of the transconjugants indicate that both soybean specificity for nodulation and cultivar specificity for nitrogen fixation are plasmid encoded.

  18. 26 CFR 31.3121(b)(19)-1 - Services of certain nonresident aliens.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Services of certain nonresident aliens. 31.3121... 1954) General Provisions § 31.3121(b)(19)-1 Services of certain nonresident aliens. (a) (1) Services performed after 1961 by a nonresident alien individual who is temporarily present in the United States as...

  19. 19 CFR 191.194 - Action on application to participate in compliance program.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Action on application to participate in compliance... SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Drawback Compliance Program § 191.194 Action on application to participate in compliance program. (a) Review by applicable drawback office—(1) General. It...

  20. 77 FR 57594 - Comment Request for Information Collection for the ETA 191, Statement of Expenditures and...

    Science.gov (United States)

    2012-09-18

    ... Employment and Training Administration Comment Request for Information Collection for the ETA 191, Statement... Administration (ETA), Labor. ACTION: Notice. SUMMARY: The Department of Labor (Department), as part of its... requirements on respondents can be properly assessed. Currently, ETA is soliciting comments concerning...

  1. Field spectrometer (S191H) preprocessor tape quality test program design document

    Science.gov (United States)

    Campbell, H. M.

    1976-01-01

    Program QA191H performs quality assurance tests on field spectrometer data recorded on 9-track magnetic tape. The quality testing involves the comparison of key housekeeping and data parameters with historic and predetermined tolerance limits. Samples of key parameters are processed during the calibration period and wavelength cal period, and the results are printed out and recorded on an historical file tape.

  2. 19 CFR Appendix B to Part 191 - Sample Formats for Applications for Specific Manufacturing Drawback Rulings

    Science.gov (United States)

    2010-04-01

    ... (see § 191.8(a)).) LOCATION OF FACTORY (Give the address of the factory(s) where the process of.... In addition, a person within a business entity with a Customs power of attorney for the company may... industry and is not a selection on your part. An option by you not to choose to sell or use the waste...

  3. 40 CFR 267.191 - What are the required design and construction standards for new tank systems or components?

    Science.gov (United States)

    2010-07-01

    ... construction standards for new tank systems or components? 267.191 Section 267.191 Protection of Environment... required design and construction standards for new tank systems or components? You must ensure that the foundation, structural support, seams, connections, and pressure controls (if applicable) are...

  4. MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation

    Energy Technology Data Exchange (ETDEWEB)

    Lena, A.M.; Mancini, M.; Rivetti di Val Cervo, P. [University of ' Tor Vergata' , Department of Experimental Medicine and Biochemical Sciences, Via Montpellier 1, Rome 00133 (Italy); Istituto Dermopatico dell' Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IDI-IRCCS), Laboratory of Biochemistry c/o Department of Experimental Medicine and Biochemical Sciences, University of Rome ' Tor Vergata' , Rome 00133 (Italy); Saintigny, G.; Mahe, C. [CHANEL Parfums Beaute, 135 av. Charles de Gaulle, F 92521, Neuilly/Seine (France); Melino, G., E-mail: gerry.melino@uniroma2.it [University of ' Tor Vergata' , Department of Experimental Medicine and Biochemical Sciences, Via Montpellier 1, Rome 00133 (Italy); Istituto Dermopatico dell' Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IDI-IRCCS), Laboratory of Biochemistry c/o Department of Experimental Medicine and Biochemical Sciences, University of Rome ' Tor Vergata' , Rome 00133 (Italy); Association Cell Death and Differentiation c/o Department of Experimental Medicine and Biochemical Sciences, University of Rome ' Tor Vergata' , Rome 00133 (Italy); and others

    2012-07-06

    Highlights: Black-Right-Pointing-Pointer miR-191 expression is upregulated in senescencent human epidermal keratinocytes. Black-Right-Pointing-Pointer miR-191 overexpression is sufficient per se to induce senescence in keratinocytes. Black-Right-Pointing-Pointer SATB1 and CDK6 are downregulated in senescence and are direct miR-191 targets. Black-Right-Pointing-Pointer SATB1 and CDK6 silencing by siRNA triggers senescence in HEKn cells. -- Abstract: Keratinocyte replicative senescence has an important role in time-dependent changes of the epidermis, a tissue with high turnover. Senescence encompasses growth arrest during which cells remain metabolically active but acquire a typical enlarged, vacuolar and flattened morphology. It is also accompanied by the expression of endogenous senescence-associated-{beta}-galactosidase and specific gene expression profiles. MicroRNAs levels have been shown to be modulated during keratinocytes senescence, playing key roles in inhibiting proliferation and in the acquisition of senescent markers. Here, we identify miR-191 as an anti-proliferative and replicative senescence-associated miRNA in primary human keratinocytes. Its overexpression is sufficient per se to induce senescence, as evaluated by induction of several senescence-associated markers. We show that SATB1 and CDK6 3 Prime UTRs are two miR-191 direct targets involved in this pathway. Cdk6 and Satb1 protein levels decrease during keratinocytes replicative senescence and their silencing by siRNA is able to induce a G1 block in cell cycle, accompanied by an increase in senescence-associated markers.

  5. 麻疹减毒活疫苗S191生产用毒株的遗传稳定性%Genetic Stability of S191 Strain for Production of Live Attenuated Measles Vaccine

    Institute of Scientific and Technical Information of China (English)

    赵炜炜; 封多佳; 董小曼

    2009-01-01

    目的 分析麻疹减毒活疫苗S191生产用毒株病毒结构基因的遗传稳定性.方法 将北京天坛生物制品股份有限公司(天坛生物)用于麻疹疫苗生产的S191株25代病毒(S191-BJ25)传至29代(S191-BJ29),上海生物制品研究所保存的S191株24代病毒(S191-SH24)传至33代(S191-SH33).从S191株传代病毒中提取RNA,对病毒结构基因片段N、M、F,H进行扩增及测序.将测序结果与GenBank中1994年收录的S191株麻疹病毒的相应序列进行比较分析.结果 S191-BJ25传代病毒N、M、F、H 4个基因的总突变率为0.02%,S191-SH2A传代病毒为0.15%;与1994年的S191疫苗株相比,S191-BJ25传代病毒N、M、F、H 4个基因的总突变率为0.3%,S191-SH24传代病毒为0.4%.结论 目前天坛生物使用的麻疹疫苗S191株生产用三级种子库具有可靠的遗传稳定性,从主代种子到疫苗的传代过程中,N、M、F、H结构基因表现出稳定的分子遗传特征.目前使用的S191毒株的4个结构基因较1994年以前的疫苗株发生了变化.但目前没有证据表明这些变化对免疫原性产生不利影响.%Objective To analyze the genetic stability of structural gene of S191 strain for production of live attenuated measles vaccine.Methods The S191 strain for production of measles vaccine by Beijing Tiantan Biological Products Co.Ltd Was subcuhured from passage 25(S191-BJ25)to 29 (S191-BJ29),and that by Shanghai Institute of Biological Products from passage 24(S191-SH24)to 33(S191-SH33).RNAs were extracted from the subcultured strains for amplification and sequencing of structural gene fragments N,M,F and H.The sequencing results were compared with those of the corresponding sequences of S191 strain included in GenBank in 1994.Results The total mutation rate of N,M,F and H genes of subcultured S191-BJ25 Was 0.02%.while that of subcuhured S191-SH24 was 0.15%.Compared with those of S191 strain included in GenBank in 1994,the total mutation rate of the four genes of

  6. Characterization of the target DNA sequence for the DNA-binding domain of zinc finger protein 191

    Institute of Scientific and Technical Information of China (English)

    Haoyue Wang; Ruilin Sun; Guoxiang Liu; Minghui Yao; Jian Fei; Hebai Shen

    2008-01-01

    Studies on the DNA-binding properties of transcription factors are important in searching for the downstream genes regulated by these factors. In the present study, we report on the DNA-binding property of a Cys2His2-type transcription factor, zinc finger protein 191 (Zfp191), which has been newly found to play a significant role in mice.By constructing a fusion protein containing the DNA-binding domain of Zfp191,we characterized target DNA by determining the protein's binding specificity and dependence on zinc.The data showed that the DNA-binding domain of Zfp191can specifically bind to the TCAT repeat motif and that there is a cooperative effect among the target DNA's multiple binding sites.Furthermore,the binding reaction is dependent on zinc.This work provides a foundation for further studies on the role of Zfp191 in gene regulation and development.

  7. Effect of arginine on stability of GST-ZNF191(243-368)

    Institute of Scientific and Technical Information of China (English)

    Dong Xin Zhao; Zhong Xian Huang

    2007-01-01

    For better understanding the chemical or biological information of ZNF191 (243-368), we expressed the fusion protein of GST and ZNF191(243-368), and used it to obtain the binding DNA sequence of this zinc finger protein. But in the process of expression and purification, we found this fusion protein slowly degradated. For resolving this problem, we simultaneously added charged amino acids L-Arg and L-Glu to the solution of fusion protein, and demonstrated that this method can dramatically increase the stability of this fusion protein. This method can make the fusion protein suitable for the continuous works, especially for situations where high protein concentration and long-term stability without precipitate and degradation of protein are required.

  8. Critical comments on the US Environmental Protection Agency Standards 40 CFR 191

    Energy Technology Data Exchange (ETDEWEB)

    Pflum, C.G. [Science Applications International Corp., Las Vegas, NV (United States); Van Konynenburg, R.A. [Lawrence Livermore National Lab., CA (United States); Krishna, P. [TRW, Inc., Washington, DC (United States)

    1993-01-14

    This paper is about the US Environmental Protection Agency (EPA) ``Environmental Standards for the Disposal of Spent Nuclear Fuel, High-Level and Transuranic Wastes,`` 40 CFR 191. These standards regulate the disposal of radioactive wastes in geologic repositories. Currently, two repository sites are under investigation: The Waste Isolation Pilot Plant (WIPP) site, located near Carlsbad, New Mexico, may become the repository for defense-generated transuranic waste (TRU); and the Yucca Mountain site, located near Las Vegas, Nevada, may become the repository for spent reactor fuel and a small amount of reprocessing waste (hereinafter called high-level radioactive waste or HLW). The paper was written for readers who have an interest in 40 CFR 191 but do not have the time or inclination to ponder the technical details.

  9. Modulation of acridine mutagen ICR191 intercalation to DNA by methylxanthines--analysis with mathematical models.

    Science.gov (United States)

    Gołuński, Grzegorz; Woziwodzka, Anna; Iermak, Ievgeniia; Rychłowski, Michał; Piosik, Jacek

    2013-06-01

    Caffeine (CAF) and other methylxanthines (MTX) may interact directly with several aromatic, intercalating ligands through mixed stacking aggregation. Formation of such stacking hetero-complexes may decrease their free form concentration and, in consequence, diminish their biological activity, which is often related to their direct interaction with DNA. In this paper interactions of acridine mutagen (ICR191) with DNA in the presence of three MTX: caffeine (CAF), pentoxifylline (PTX) and theophylline (TH) are investigated. Several mathematical models are used to calculate all association constant values and every component concentration in each analyzed mixture. Model McGhee-von Hippel is used to analyze ligand-DNA interaction, and model Zdunek et al.--to analyze ligand-MTX interactions. Finally, two distinct mathematical models are employed to analyze three-component mixture containing ligand, MTX and DNA molecules. The first model describes possible interactions of ligand with DNA and MTX, and rejects direct MTX interactions with DNA. The second model describes all interactions mentioned above and, additionally, allows MTX to interact directly with DNA. Results obtained using these models are similar. However, correspondence of theoretical results to experimental data is better for the first model than the second one. In this paper possible interactions of ICR191 with eukaryotic cell chromatin are also analyzed, showing that CAF reduces acridine mutagen potential to interact directly with cell chromatin. Additionally, it is demonstrated that MTX inhibit mutagenic activity of ICR191 in a dose-dependent manner. Furthermore, biological activity of ICR191-MTX mixtures corresponds with concentration of free mutagen form calculated using appropriate mathematical model.

  10. Mutation induction in Haemophilus influenzae by ICR-191 II. Role of DNA replication and repair

    Energy Technology Data Exchange (ETDEWEB)

    Kimball, R.F.; Perdue, S.W.

    1981-01-01

    Evidence is presented to show that presumptive frameshift mutations induced in Haemophilus influenzae by ICR-191 are fixed very repidly, essentially at the time of treatment. DNA synthesis during treatment is essential for fixation, but DNA synthesis after treatment has no effect. The conclusion is drawn that the mutagen acts at the replication fork, possibly to stabilize misannealings arising in association with the discontinuities in the newly synthesized DNA. (JMT)

  11. Expression and Purification of ZNF191(243-368) in Three Expression Systems

    Institute of Scientific and Technical Information of China (English)

    ZHAO Dong-Xin; TENG Xin-Cheng; DING Zhi-Chun; HUANG Zhong-Xian

    2007-01-01

    ZNF191(243-368), a new human zinc finger protein, probably relates to some hereditary diseases and cancers.To obtain adequate amount of ZNF 191 (243-368) for the study of its property, structure and function, three different expression systems of inclusion-body, glutathione S-transferase (GST), and hexahistidine (6 × His) were used and compared. Among these systems, the expression level of ZNF191(243-368) was increased in inclusion body system under a higher isopropylthio-β-D-galactoside (IPTG) concentration, but the non-target proteins were also increased more, which made its purification more difficult and the yield lower. The expression of His-tag fusion protein was almost not affected by IPTG concentration, temperature and inducing time. At a high IPTG concentration the highest expression yield for GST fusion protein was obtained. And the fusion proteins can be partially purified by a single affinity chromatography step. The fusion protein systems show advantages for expression of these proteins.

  12. miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1.

    Science.gov (United States)

    Zhang, Lingbo; Flygare, Johan; Wong, Piu; Lim, Bing; Lodish, Harvey F

    2011-01-15

    Using RNA-seq technology, we found that the majority of microRNAs (miRNAs) present in CFU-E erythroid progenitors are down-regulated during terminal erythroid differentiation. Of the developmentally down-regulated miRNAs, ectopic overexpression of miR-191 blocks erythroid enucleation but has minor effects on proliferation and differentiation. We identified two erythroid-enriched and developmentally up-regulated genes, Riok3 and Mxi1, as direct targets of miR-191. Knockdown of either Riok3 or Mxi1 blocks enucleation, and either physiological overexpression of miR-191 or knockdown of Riok3 or Mxi1 blocks chromatin condensation. Thus, down-regulation of miR-191 is essential for erythroid chromatin condensation and enucleation by allowing up-regulation of Riok3 and Mxi1.

  13. Summary of IAU colloquium 191: the environment and Evolution of binary and multiple stars

    Directory of Open Access Journals (Sweden)

    Edward F. Guinan

    2004-01-01

    Full Text Available Se presenta un resumen del Coloquio 191 de la UAI \\El Entorno y la Evoluci on de las Estrellas Binarias y M ultiples". Esta conferencia se celebr o en M erida, M exico, en febrero de 2003, y estuvo dedicada al Dr. Arcadio Poveda, por sus importantes contribuciones al campo de las estrellas binarias y m ultiples y su din amica. La conferencia se organiz o para discutir los principales desarrollos que est an ocurriendo en los campos de formaci on de binarias y m ultiples, su evoluci on, su din amica y el entorno en donde se forman y evolucionan.

  14. Status of Waste Isolation Pilot Plant compliance with 40 CFR 191B, December 1992

    Energy Technology Data Exchange (ETDEWEB)

    Marietta, M.G.; Anderson, D.R.

    1993-10-01

    Before disposing of transuranic radioactive waste at the Waste Isolation Pilot Plant (WIPP), the US Department of Energy (DOE) must evaluate compliance with long-term regulations of the US Environmental Protection Agency (EPA). Sandia National Laboratories (SNL) is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for final compliance evaluations. This paper describes the 1992 preliminary comparison with Subpart B of the Environmental Standards for the Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191), which regulates long-term releases of radioactive waste. Results of the 1992 PA are preliminary, and cannot be used to determine compliance or noncompliance with EPA regulations because portions of the modeling system and data base are incomplete. Results are consistent, however, with those of previous iterations of PA, and the SNL WIPP PA Department has high confidence that compliance with 40 CFR 191B can be demonstrated. Comparison of predicted radiation doses from the disposal system also gives high confidence that the disposal system is safe for long-term isolation.

  15. miR-191 May Regulate Pig Preadipocyte Differentiation by Targeting The Transcription Factor C/EBPβ%miR-191通过调控C/EBPβ转录影响猪前体脂肪细胞分化

    Institute of Scientific and Technical Information of China (English)

    刘帅; 宁小敏; 李美航; 仇杨; 李艳杰; 董培越; 杨公社

    2013-01-01

    对实验室前期Solexa结果进行深入挖掘,结合生物信息学分析从不同发育阶段猪皮下脂肪组织差异表达的miRNAs中筛选出高丰度差异极显著的候选miR-191.采用腺病毒过表达miR-191,实时定量PCR、Western blot及双荧光素酶报告基因检测等技术方法,初步研究miR-191对猪前体脂肪细胞分化的影响.结果发现,miR-191随着猪前体脂肪细胞的分化表达量逐渐增加.与对照组相比,过表达miR-191的猪前体脂肪细胞中miR-191转录本显著增加,并引起CCAAT增强子结合蛋白β(C/EBPβ)、PPARγ和aP2的mRNA水平降低,抑制了猪前体脂肪细胞分化.同时,Western blot结果显示,与对照组相比过表达miR-191的猪前体脂肪细胞在48 h C/EBPβ蛋白水平下降了55%.更重要的是,通过TargetScan等算法正向筛选以及MicroInspector反向筛选联合获得miR-191候选靶基因,经双荧光素酶报告基因检测结果证实,miR-191可直接作用于C/EBPβ 3'UTR,从而降低萤火虫荧光素酶活性.综上所述,miR-191可能通过抑制脂肪细胞分化早期标志基因C/EBPβ的表达,从而抑制了猪前体脂肪细胞的分化.%Based on our previous solexa sequencing data, combining with bioinformatics analysis of microRNA expression changes in porcine adipose tissue from different growth phases in a model of obesity, we found the expression level of miR-191 was significantly different in developing swine adipose tissue. In this research, we successfully overexpressed miR-191's transcripts by recombinant adenovirus in primary cultured porcine preadipocytes, and then investigated the impact on differentiation of pig preadipocyte by Real-time quantitative PCR, Western blot. The results showed that miR-191's expression level gradually increased during differentiation. The miR-191 transcripts increased dramatically when miR-191 overexpressed compared to the control group, which caused the decrease of C/EBPp, PPARy and aP2's mRNA level and the

  16. The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis.

    Directory of Open Access Journals (Sweden)

    Fang Yang

    Full Text Available Ubiquitin E3 ligases target their substrates for ubiquitination, leading to proteasome-mediated degradation or altered biochemical properties. The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule proteolytic pathway, recognizes proteins with N-terminal destabilizing residues and plays an important role in spermatogenesis. Tex19.1 (also known as Tex19 has been previously identified as a germ cell-specific protein in mouse testis. Here we report that Tex19.1 forms a stable protein complex with Ubr2 in mouse testes. The binding of Tex19.1 to Ubr2 is independent of the second position cysteine of Tex19.1, a putative target for arginylation by the N-end rule pathway R-transferase. The Tex19.1-null mouse mutant phenocopies the Ubr2-deficient mutant in three aspects: heterogeneity of spermatogenic defects, meiotic chromosomal asynapsis, and embryonic lethality preferentially affecting females. In Ubr2-deficient germ cells, Tex19.1 is transcribed, but Tex19.1 protein is absent. Our results suggest that the binding of Ubr2 to Tex19.1 metabolically stabilizes Tex19.1 during spermatogenesis, revealing a new function for Ubr2 outside the conventional N-end rule pathway.

  17. Overview of the AVT-191 Project to Assess Sensitivity Analysis and Uncertainty Quantification Methods for Military Vehicle Design

    Science.gov (United States)

    Benek, John A.; Luckring, James M.

    2017-01-01

    A NATO symposium held in 2008 identified many promising sensitivity analysis and un-certainty quantification technologies, but the maturity and suitability of these methods for realistic applications was not known. The STO Task Group AVT-191 was established to evaluate the maturity and suitability of various sensitivity analysis and uncertainty quantification methods for application to realistic problems of interest to NATO. The program ran from 2011 to 2015, and the work was organized into four discipline-centric teams: external aerodynamics, internal aerodynamics, aeroelasticity, and hydrodynamics. This paper presents an overview of the AVT-191 program content.

  18. The heating of X-ray gas by radio gas in cluster PKS0745-191

    Science.gov (United States)

    Xiang, F.; Chen, Y.; Wu, M.; Lu, F. J.; Song, L. M.; Jia, S. M..

    2004-05-01

    A calculation about the energy evolution of the relativistic particles in galaxy clusters is presented. The heating of X-ray gas by radio gas in cluster PKS 0745-191 is derived through a combined analysis of Chandra data and VLA radio observations. It was found that the heating of X-ray gas by radio gas is not enough to supply the energy lose by the X-ray emission when the low energy cut-off in the power-law spectrum of the relativistic electrons is set to 0.001erg. Therefore further computing is made to study the heating of X-ray gas by radio gas with different low energy cut-off is computed and the low energy cut-off values.

  19. High-Resolution Spectroscopy of G191-B2B in the Extreme Ultraviolet

    CERN Document Server

    Cruddace, R G; Yentis, D J; Brown, C M; Gursky, H; Barstow, M A; Bannister, N P; Fraser, G W; Spragg, J E; Lapington, J S; Tandy, J A; Sanderson, B; Culhane, J L; Barbee, T W; Kordas, J F; Goldstein, W H; Fritz, G G

    2001-01-01

    We report a high-resolution (R=3000-4000) spectroscopic observation of the DA white dwarf G191-B2B in the extreme ultraviolet band 220-245 A. A low- density ionised He component is clearly present along the line-of-sight, which if completely interstellar implies a He ionisation fraction considerably higher than is typical of the local interstellar medium. However, some of this material may be associated with circumstellar gas, which has been detected by analysis of the C IV absorption line doublet in an HST STIS spectrum. A stellar atmosphere model assuming a uniform element distribution yields a best fit to the data which includes a significant abundance of photospheric He. The 99-percent confidence contour for the fit parameters excludes solutions in which photospheric He is absent, but this result needs to be tested using models allowing abundance gradients.

  20. The D/H Ratio in Interstellar Gas toward G191-B2B

    Science.gov (United States)

    Sahu, M. S.; Landsman, W.; Bruhweiler, F. C.; Gull, T. R.; Bowers, C. A.; Lindler, D.; Feggans, K.; Barstow, M. A.; Hubeny, I.; Holberg, J. B.

    1999-10-01

    Recent analysis of Goddard High-Resolution Spectrograph (GHRS) echelle spectra suggests ~30% variations in the D/H abundance ratio along the line of sight to the nearby (69 pc) hot white dwarf (WD) G191-B2B (Vidal-Madjar et al.). Variations in the D/H ratio on such short length scales imply nonuniform production/destruction of deuterium and an inefficient mixing of gas in the local interstellar medium (LISM). We reinvestigate the question of the spatial variation of the local D/H abundance using both archival GHRS spectra and new echelle spectra of G191-B2B obtained with the Space Telescope Imaging Spectrograph (STIS) aboard the Hubble Space Telescope. The STIS spectra were obtained in the high-resolution (E140H) mode and cover the wavelength region ranging from 1140 to 1700 Å. Our analysis uses stratified line-blanketed non-LTE model atmosphere calculations to determine the shape of the intrinsic WD Lyα profile and to estimate the WD photospheric contamination of the interstellar lines. Although three velocity components were reported previously toward G191-B2B, we deduce only two velocity components. The first component is at vhel~8.6 km s-1, and the second is at vhel~19.3 km s-1, which we identify with the local interstellar cloud (LIC). From the STIS data, we derive D/H = 1.60+0.39-0.27×10-5 for the LIC component and D/H>1.26×10-5 for the 8.6 km s-1 component (uncertainties denote 2σ or 95% confidence limits). The derived D/H values in both components are consistent with (D/H)LIC = (1.5+/-0.1)×10-5, which was determined by Linsky in 1998. The STIS data provide no evidence for local or component-to-component variation in the D/H ratio. Our reanalysis of the GHRS data gives essentially the same results as Vidal-Madjar et al., despite using two velocity components for the profile fitting (vs. three by Vidal-Madjar et al.) and a more physically realistic WD Lyα profile for G191-B2B. The GHRS data indicate a component-to-component variation as well as a

  1. 77 FR 30335 - Proposed Revision 3 to Standard Review Plan, Section 19.1 on Determining the Technical Adequacy...

    Science.gov (United States)

    2012-05-22

    ... Probabilistic Risk Assessment for Risk-Informed License Amendment Requests After Initial Fuel Load AGENCY... of Safety Analysis Reports for Nuclear Power Plants: LWR Edition,'' on a proposed Revision 3 to Standard Review Plan (SRP), Section 19.1, ``Determining the Technical Adequacy of Probabilistic...

  2. 10 CFR 501.191 - Use of natural gas or petroleum for certain unanticipated equipment outages and emergencies...

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Use of natural gas or petroleum for certain unanticipated... Natural Gas or Petroleum for Emergency and Unanticipated Equipment Outage Purposes § 501.191 Use of natural gas or petroleum for certain unanticipated equipment outages and emergencies defined in...

  3. 19 CFR 191.176 - Procedures for claims filed under 19 U.S.C. 1313(p).

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Procedures for claims filed under 19 U.S.C. 1313(p... § 191.176 Procedures for claims filed under 19 U.S.C. 1313(p). (a) Applicability. The general procedures for filing drawback claims shall be applicable to claims filed under 19 U.S.C. 1313(p)...

  4. The relation of cationic trypsinogen gene G191R mutation and pathogenesis of pancreatitis%阴离子型胰蛋白酶原基因G191R突变与胰腺炎发病的关系

    Institute of Scientific and Technical Information of China (English)

    李璐; 丁辉; 杨玉秀; 韩双印; 王春荣

    2014-01-01

    目的 分析阴离子型胰蛋白酶原(PRSS2)基因G191R突变在急性胰腺炎(AP)和慢性胰腺炎(CP)患者中的发生率,探讨PRSS2基因突变对胰腺炎易感性的影响.方法 采集82例AP、73例CP及138例健康体检者的血液标本,提取基因组DNA.应用巢式PCR对PRSS2基因进行扩增.PCR产物用Hpy188Ⅲ酶切,行限制性片段长度多态性分析(RFLP),部分产物测序验证.结果 PRSS2基因的巢式PCP产物长度为436 bp,RFLP2获得309 bp和127 bp两个片段,为RPSS2基因G191R突变(即GGA→AGA)所致.DNA测序证实PRSS2基因G191R突变.AP患者中5例发生RPSS2基因G191R突变,突变率为6.1%(5/82),OR=0.682,95% CI 0.231 ~ 2.010; CP患者突变率为1.4% (1/73),OR =0.145,95% CI 0.019~1.145;健康对照组为8.7% (12/138).CP组的G191R突变率显著低于健康对照组(x2 =0.432,P=0.035),而AP组与健康对照组的差异无统计学意义(x2=0.487,P=0.485).结论 PRSS2基因G191R突变可促进阴离子型胰蛋白酶原的降解,降低慢性胰腺炎的发生率.%Objective To observe the prevalence of anionic trypsinogen (PRSS2) gene G191R mutation in patients with acute pancreatitis (AP) and chronic pancreatitis (CP),and to investigate the effect of PRSS2 gene G191R mutation on susceptibility to pancreatitis.Methods The blood samples of 82 patients with acute pancreatitis,73 patients with chronic pancreatitis and 138 healthy subjects were collected,and genomic DNA was extracted.Nest PCR were performed to amplify PRSS2 gene and restriction fragment length polymorphism (RFLP) was followed by using Hpy188Ⅲ to distinguish the G191R mutation.DNA sequencing analysis was performed to confirm the mutation status.Results The size of nest PCR products was 436 bp.RFLP2 produced 309 bp and 127 bp fragments,which were resulted from PRSS2 gene G191R mutation (GGA →AGA).DNA sequencing analysis of the PCR products further confirmed the PRSS2 gene G191R mutation.Five of eighty-two(6.1%) patients with acute

  5. Distinct cell surface appendages produced by Sinorhizobium fredii USDA257 and S. fredii USDA191, cultivar-specific and nonspecific symbionts of soybean

    Science.gov (United States)

    Sinorhizobium fredii USDA257 and S. fredii USDA191 are fast-growing rhizobia that form nitrogen-fixing nodules on soybean roots. In contrast to USDA191, USDA257 exhibits cultivar specificity and can form nodules only on primitive soybean cultivars. In response to flavonoids released from soybean ro...

  6. Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice

    DEFF Research Database (Denmark)

    Ollinger, Rupert; Childs, Andrew J; Burgess, Hannah M

    2008-01-01

    . During male spermatogenesis, Tex19.1 expression is highest in mitotic spermatogonia and diminishes as these cells differentiate and progress through meiosis. In pluripotent stem cells, Tex19.1 expression is also downregulated upon differentiation. However, it is not clear whether Tex19.1 has an essential...... spermatogenesis. Immunostaining and histological analysis revealed defects in meiotic chromosome synapsis, the persistence of DNA double-strand breaks during meiosis, and a loss of post-meiotic germ cells in the testis. Furthermore, expression of a class of endogenous retroviruses is upregulated during meiosis...... in the Tex19.1(-/-) testes. Increased transposition of endogenous retroviruses in the germline of Tex19.1(-/-) mutant mice, and the concomitant increase in DNA damage, may be sufficient to disrupt the normal processes of recombination and chromosome synapsis during meiosis and cause defects...

  7. k191yb.m77t and k191yb.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-1-91-YB in Yakutat Bay, Alaska from 06/22/1991 to 06/28/1991

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with radar and GPS navigation data was collected as part of the U.S. Geological Survey cruise K-1-91-YB. The cruise was conducted...

  8. Multifrequency VLA observations of PKS 0745 - 191 - The archetypal 'cooling flow' radio source?

    Science.gov (United States)

    Baum, S. A.; O'Dea, C. P.

    1991-01-01

    Ninety-, 20-, 6- and 2-cm VLA observations of the high-radio-luminosity cooling-flow radio source PKS 0745 - 191 are presented. The radio source was found to have a core with a very steep spectrum (alpha is approximately -1.5) and diffuse emission with an even steeper spectrum (alpha is approximately -1.5 to -2.3) without clear indications of the jets, hotspots, or double lobes found in the other radio sources of comparable luminosity. It is inferred that the energy to power the radio source comes from the central engine, but the source's structure may be heavily influenced by the past history of the galaxy and the inflowing intracluster medium. It is shown that, while the radio source is energetically unimportant for the cluster as a whole, it is important on the scale of the cooling flow. The mere existence of cosmic rays and magnetic fields within a substantial fraction of the volume inside the cooling radius has important consequences for cooling-flow models.

  9. Spectrum of {gamma} rays from the decay of SD to normal states in {sup 191}Hg

    Energy Technology Data Exchange (ETDEWEB)

    Gassmann, D.; Khoo, T.L.; Lauritsen, T. [and others

    1995-08-01

    In B.a.7. we propose that the statistical spectrum emitted from a sharp single excited state serves as a probe of pairing in excited states. A specific test of this proposal is the comparison of the spectra from even-even and odd-even nuclei. Whereas a pair gap exists in an even-even nucleus, it gets filled in an odd-even nucleus. Consequently, low-energy transitions can arise in the latter case, whereas they are calculated to be absent in the former case because very few levels exist in the cold gap region. In addition, transitions between 1.4 - 2.2 MeV, which {open_quotes}jump{close_quotes} across the gap, are predicted to have lower yield in the odd-even nuclei. Serendipitously, decay from a superdeformed state serves as a good initial excited sharp state. We extracted the spectrum pairwise-coincident with SD lines in {sup 191}Hg from Gammasphere data and compared it with the equivalent spectra from the even-even nuclei {sup 192,194}Hg. The differences that are predicted to occur are indeed observed. Thus, the data support our proposal that the reduction of pairing with thermal excitation energy can be probed with statistical decay spectra.

  10. Phytase production through response surface methodology and molecular characterization of Aspergillus fumigatus NF191.

    Science.gov (United States)

    Gangoliya, Shivraj Singh; Gupta, Raj Kishor; Singh, Nand Kumar

    2015-06-01

    Phytase play an important role in phytic acid catalysis that act as a food inhibitor in cereals. Here, we isolated high phytase producing isolates NF191 closely related to Aspergillus fumigatus sp. from piggery soil. DNA was isolated from the fungal culture and amplified the ITS region using ITS1 and ITS4 primer using PCR. The 400-900 bp amplicon was gel eluted and subjected to sequencing. The sequencing results were assembled and compared with NCBI data base which showed the 99% identity of Aspergillus fumigatus. Different carbon sources viz., fructose, galactose, lactose, dextrose, sucrose, maltose and different nitrogen sources (organic & inorganic) NH4Cl, NH4NO3, (NH4)2SO4, KNO3, NaNO3, urea, yeast extract, peptone, beef extract were tested for optimal production. The 0.3% dextrose, 0.5% NH4NO3 and 96 h incubation time showed the best production and enzyme activity at 45 degrees C incubation temperature. The selected parameters, dextrose, ammonium sulphate and incubation time, when employed with statistical optimization approach involving response surface optimization using Box Behnken Design, gave a 1.3 fold increase in phytase production compared to unoptimized condition.

  11. ALMA observations of cold molecular gas filaments trailing rising radio bubbles in PKS0745-191

    CERN Document Server

    Russell, H R; Fabian, A C; Nulsen, P E J; Edge, A C; Combes, F; Murray, N W; Parrish, I J; Salome, P; Sanders, J S; Baum, S A; Donahue, M; Main, R A; O'Connell, R W; O'Dea, C P; Oonk, J B R; Tremblay, G; Vantyghem, A N; Voit, G M

    2016-01-01

    We present ALMA observations of the CO(1-0) and CO(3-2) line emission tracing filaments of cold molecular gas in the central galaxy of the cluster PKS0745-191. The total molecular gas mass of 4.6 +/- 0.3 x 10^9 solar masses, assuming a Galactic X_{CO} factor, is divided roughly equally between three filaments each extending radially 3-5 kpc from the galaxy centre. The emission peak is located in the SE filament roughly 1 arcsec (2 kpc) from the nucleus. The velocities of the molecular clouds in the filaments are low, lying within +/-100 km/s of the galaxy's systemic velocity. Their FWHMs are less than 150 km/s, which is significantly below the stellar velocity dispersion. Although the molecular mass of each filament is comparable to a rich spiral galaxy, such low velocities show that the filaments are transient and the clouds would disperse on <10^7 yr timescales unless supported, likely by the indirect effect of magnetic fields. The velocity structure is inconsistent with a merger origin or gravitational ...

  12. Feedback, scatter and structure in the core of the PKS 0745-191 galaxy cluster

    CERN Document Server

    Sanders, J S; Hlavacek-Larrondo, J; Russell, H R; Taylor, G B; Hofmann, F; Tremblay, G; Walker, S A

    2014-01-01

    We present Chandra X-ray Observatory observations of the core of the galaxy cluster PKS 0745-191. Its centre shows X-ray cavities caused by AGN feedback and cold fronts with an associated spiral structure. The cavity energetics imply they are powerful enough to compensate for cooling. Despite the evidence for AGN feedback, the Chandra and XMM-RGS X-ray spectra are consistent with a few hundred solar masses per year cooling out of the X-ray phase, sufficient to power the emission line nebula. The coolest X-ray emitting gas and brightest nebula emission is offset by around 5 kpc from the radio and X-ray nucleus. Although the cluster has a regular appearance, its core shows density, temperature and pressure deviations over the inner 100 kpc, likely associated with the cold fronts. After correcting for ellipticity and projection effects, we estimate density fluctuations of ~4 per cent, while temperature, pressure and entropy have variations of 10-12 per cent. We describe a new code, MBPROJ, able to accurately obt...

  13. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    The Waste Isolation Pilot Plant (WIPP) is a research and development facility for the demonstration of the permanent isolation of transuranic radioactive wastes in a geologic formation. The facility was constructed in southeastern New Mexico in a manner intended to meet criteria established by the scientific and regulatory community for the safe, long-term disposal of transuranic wastes. The US Department of Energy (DOE) is preparing an application to demonstrate compliance with the requirements outlined in Title 40, Part 191 of the Code of Federal Regulations (CFR) for the permanent disposal of transuranic wastes. As mandated by the Waste Isolation Pilot Plant (WIPP) Land Withdrawal Act of 1992, the US Environmental Protection Agency (EPA) must evaluate this compliance application and provide a determination regarding compliance with the requirements within one year of receiving a complete application. Because the WIPP is a very complex program, the DOE has planned to submit the application as a draft in two parts. This strategy will allow for the DOE and the EPA to begin technical discussions on critical WIPP issues before the one-year compliance determination period begins. This report is the first of these two draft submittals.

  14. MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803

    Institute of Scientific and Technical Information of China (English)

    Xuejun Shi; Shicang Su; Jian Long; Bing Mei; Yajun Chen

    2011-01-01

    As a family of post-transcriptional regulator of gene expression,the microRNAs (miRNAs) control a wide array of biological processes including cell differentiation,proliferation and apoptosis,and the dysregulation of miRNAs is a hallmark of cancer.Here,we found that the microRNA-191 (miR-191) was at a high-expression level in human gastric adenocarcinoma cell line MGC803 and human gastric cancer tissues.The results of 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and colony formation assays showed that miR-191 could promote cell growth and suppress apoptosis of MGC803 cells.The N-deacetylase/N-sulfotransferase 1 (NDST1) was confirmed to be a direct target gene of miR-191 by enhanced green fluorescent protein reporter experiment.The mRNA and protein levels of NDST1 were inversely correlated with miR-191 in MGC803 cells,suggesting the negative regulation of NDST1 by miR-191.Furthermore,NDST1 played an inhibitory role and could suppress MGC803 cell proliferation.Our findings suggested that miR-191 could act as an oncogene in MGC803 cells,and the cellular function was partially due to its negative regulation of NDST1.

  15. Involvement of the salicylic acid signaling pathway in the systemic resistance induced in Arabidopsis by plant growth-promoting fungus Fusarium equiseti GF19-1.

    Science.gov (United States)

    Kojima, Hanae; Hossain, Md Motaher; Kubota, Mayumi; Hyakumachi, Mitsuro

    2013-01-01

    Plant growth-promoting fungi (PGPF) are effective biocontrol agents for a number of soil-borne diseases and are known for their ability to trigger induced systemic resistance (ISR). In this study, we investigated the mechanisms triggered by PGPF Fusarium equiseti GF19-1, which is known to increase pathogen resistance in plants, by using GF19-1 spores and the culture filtrate (CF) to treat the roots of Arabidopsis thaliana. Subsequently, the leaves were challenged with Pseudomonas syringae pv tomato DC3000 (Pst) bacteria. Arabidopsis plants treated with GF19-1 spores or the CF elicited ISR against the Pst pathogen, resulting in a restriction of disease severity and suppression of pathogen proliferation. Examination of ISR in various signaling mutants and transgenic plants showed that GF19-1-induced protection was observed in the jasmonate response mutant jar1 and the ethylene response mutant etr1, whereas it was blocked in Arabidopsis plants expressing the NahG transgene or demonstrating a disruption of the NPR1 gene (npr1). Analysis of systemic gene expression revealed that GF19-1 modulates the expression of salicylic acid (SA)-responsive PR-1, PR-2, and PR-5 genes. Moreover, transient accumulation of SA was observed in GF19-1-treated plant, whereas the level was further enhanced after Pst infection of GF19-1-pretreated plants, indicating that accumulation of SA was potentiated when Arabidopsis plants were primed for disease resistance by GF19-1. In conclusion, these findings imply that the induced protective effect conferred by F. equiseti GF19-1 against the leaf pathogen Pst requires responsiveness to an SA-dependent pathway.

  16. Draft Genome Sequence of the D-Xylose-Fermenting Yeast Spathaspora arborariae UFMG-HM19.1AT.

    Science.gov (United States)

    Lobo, Francisco P; Gonçalves, Davi L; Alves, Sergio L; Gerber, Alexandra L; de Vasconcelos, Ana Tereza R; Basso, Luiz C; Franco, Glória R; Soares, Marco A; Cadete, Raquel M; Rosa, Carlos A; Stambuk, Boris U

    2014-01-16

    The draft genome sequence of the yeast Spathaspora arborariae UFMG-HM19.1A(T) (CBS 11463 = NRRL Y-48658) is presented here. The sequenced genome size is 12.7 Mb, consisting of 41 scaffolds containing a total of 5,625 predicted open reading frames, including many genes encoding enzymes and transporters involved in d-xylose fermentation.

  17. Preliminary comparison with 40 CFR Part 191, Subpart B for the Waste Isolation Pilot Plant, December 1990

    Energy Technology Data Exchange (ETDEWEB)

    Bertram-Howery, S.G.; Marietta, M.G.; Rechard, R.P.; Anderson, D.R. (Sandia National Labs., Albuquerque, NM (USA)); Swift, P.N. (Tech. Reps., Inc., Albuquerque, NM (USA)); Baker, B.L. (Technadyne Engineering Consultants, Inc., Albuquerque, NM (USA)); Bean, J.E. Jr.; McCurley, R.D.; Rudeen, D.K. (New Mexico Engineering Research Inst., Albuquerque, NM (USA)); Beyeler, W.; Brinster, K.F.; Guzowski, R.V.; Sch

    1990-12-01

    The Waste Isolation Pilot Plant (WIPP) is planned as the first mined geologic repository for transuranic (TRU) wastes generated by defense programs of the United States Department of Energy (DOE). Before disposing of waste at the WIPP, the DOE must evaluate compliance with the United states Environmental Protection Agency's (EPA) Standard, Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR Part 191, US EPA, 1985). Sandia National Laboratories (SNL) is evaluating long-term performance against criteria in Subpart B of the Standard. Performance assessment'' as used in this report includes analyses for the Containment Requirements ({section} 191.13(a)) and the Individual Protection Requirements ({section} 191.15). Because proving predictions about future human actions or natural events is not possible, the EPA expects compliance to be determined on the basis of specified quantitative analyses and informed, qualitative judgment. The goal of the WIPP performance-assessment team at SNL is to provide as detailed and thorough a basis as practical for the quantitative aspects of that decision. This report summarizes SNL's late-1990 understanding of the WIPP Project's ability to evaluate compliance with Subpart B. 245 refs., 88 figs., 23 tabs.

  18. A Title 40 Code of Federal Regulations Part 191 Evaluation of Buried Transuranic Waste at the Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    G. J. Shott, V. Yucel, L. Desotell

    2008-04-01

    In 1986, 21 m{sup 3} of transuranic (TRU) waste was inadvertently buried in a shallow land burial trench at the Area 5 Radioactive Waste Management Site on the Nevada Test Site (NTS). The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office is considered five options for management of the buried TRU waste. One option is to leave the waste in-place if the disposal can meet the requirements of Title 40 Code of Federal Regulations (CFR) Part 191, 'Environmental Radiation Protection Standard for Management and Disposal of Spent Nuclear Fuel, High-Level, and Transuranic Radioactive Wastes'. This paper describes analyses that assess the likelihood that TRU waste in shallow land burial can meet the 40 CFR 191 standards for a geologic repository. The simulated probability of the cumulative release exceeding 1 and 10 times the 40 CFR 191.13 containment requirements is estimated to be 0.009 and less than 0.0001, respectively. The cumulative release is most sensitive to the number of groundwater withdrawal wells drilled through the disposal trench. The mean total effective dose equivalent for a member of the public is estimated to reach a maximum of 0.014 milliSievert (mSv) at 10,000 years, or approximately 10 percent of the 0.15 mSv 40 CFR 191.15 individual protection requirement. The dose is predominantly from inhalation of short-lived Rn-222 progeny in air produced by low-level waste disposed in the same trench. The transuranic radionuclide released in greatest amounts, Pu-239, contributes only 0.4 percent of the dose. The member of public dose is most sensitive to the U-234 inventory and the radon emanation coefficient. Reasonable assurance of compliance with the Subpart C groundwater protection standard is provided by site characterization data and hydrologic processes modeling which support a conclusion of no groundwater pathway within 10,000 years. Limited quantities of transuranic waste in a shallow land burial trench at the

  19. Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis.

    Science.gov (United States)

    Pruszyński, Marek; Bilewicz, Aleksander; Zalutsky, Michael R

    2008-04-01

    The goal of this study was to evaluate a new approach that can be applied for labeling biomolecules with (211)At. Many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking different (211)At labeling strategies. The approach evaluated in this study was to attach astatide anions to soft metal cations, which are also complexed by a bifunctional ligand. Ultimately, this complex could in principle be subsequently conjugated to a biomolecule with the proper selection of ligand functionality. We report here the attachment of (211)At(-) and *I(-) (*I = (131)I or (125)I) anions to the soft metal cations Rh(III) and Ir(III), which are complexed by the 1,5,9,13-tetrathiacyclohexadecane-3,11-diol (16aneS4-diol) ligand. Radioactive *I(-) anions were used for preliminary studies directed at the optimization of reaction conditions and to provide a baseline for comparison of results with (211)At. Four complexes Rh[16aneS4-diol]*I/(211)At and Ir[16aneS4-diol]*I/(211)At were synthesized in high yield in a one-step procedure, and the products were characterized mainly by paper electrophoresis and reversed-phase HPLC. The influences of time and temperature of heating and concentrations of metal cations and sulfur ligand 16aneS4-diol, as well as pH on the reaction yields were determined. Yields of about 80% were obtained when the quantities of Rh(III) or Ir(III) cations and 16aneS4-diol ligand in the solutions were 62.5 nmol and 250 nmol, respectively, and the pH ranged 3.0-4.0. Syntheses required heating for 1-1.5 h at 75-80 degrees C. The influence of microwave heating on the time and completeness of the complexation reaction was evaluated and compared with the conventional method of heating in an oil bath. Microwave synthesis accelerates reactions significantly. With microwave heating, yields of about 75% for Rh[16aneS4-diol](131)I and Ir[16aneS4-diol](131)I complexes were obtained after only 20 min exposure of the reaction mixtures to

  20. 多胎妊娠早产儿191例ROP筛查结果分析%Outcomes of retinopathy of prematurity screening in 191 multiple pregnancy premature infants

    Institute of Scientific and Technical Information of China (English)

    程海霞; 姚家奇; 陈志钧

    2013-01-01

    Objective To observe the occurrence of multiple pregnancy premature ROP (Retinopathy of prematurity,ROP),and to discuss the related risk factors.Methods Of 191 cases of multiple pregnancy premature included in the study,fundus examinations were performed with Retcam Ⅱ,the incidence of the ROP and and its relationship with related risk factors were studied.The SPSS 17.0 software was applied in the statistical analysis.Results The incidence of ROP was 9.95% (19/191) in 191 cases of multiple pregnancy premature,twins was 8.79% (16/182); triplets were 33.33%(3/9).The average birth weight of 19 infants with ROP was (1.47±0.45) kg,172 cases without ROP was (1.90 ±0.45) kg,birth weight between two groups had statistical significance (t =3.91,P =0.0001); The average born age of 19 infants with ROP was (29.53 ±2.25) weeks,172 cases without ROP was (32.93 ±2.93) weeks,between the two groups,born age had statistical significance (t =6.75,P <0.0001).Conclusions The incidence of ROP with multiple pregnancy premature is higher,gestational age and birth weight are important risk factors for ROP.%目的 观察多胎妊娠早产儿ROP的发生情况,探讨相关危险因素.方法 191例多胎妊娠早产儿纳入研究,所有患儿均由经验丰富的视网膜专科医师用二代广角数码视网膜成像系统(RetCamⅡ)进行检查,研究早产儿视网膜病变(Retinopathy of prematurity,ROP)的发生率及其与胎龄、出生体重、分娩方式及有无吸氧史的关系.应用SPSS17.0统计软件分析结果.结果 191例多胎妊娠早产儿ROP发生率9.95% (19/191),发现ROP征象的19例患儿有明确吸氧史者16例.双胎妊娠ROP发生率8.79% (16/182);三胎妊娠ROP发生率33.33%(3/9);顺产100例8例发现ROP,剖宫产91例11例发现ROP; 19例ROP患儿平均出生体重(1.47±0.45) kg,无ROP的172例早产儿平均出生体重(1.90±0.45) kg,两组出生体重比较具有统计学意义(t=3.91.P=0.0001); 19

  1. Summary Findings from the AVT-191 Project to Assess Sensitivity Analysis and Uncertainty Quantification Methods for Military Vehicle Design

    Science.gov (United States)

    Benek, John A.; Luckring, James M.

    2017-01-01

    A NATO symposium held in Greece in 2008 identified many promising sensitivity analysis and uncertainty quantification technologies, but the maturity and suitability of these methods for realistic applications was not clear. The NATO Science and Technology Organization, Task Group AVT-191 was established to evaluate the maturity and suitability of various sensitivity analysis and uncertainty quantification methods for application to realistic vehicle development problems. The program ran from 2011 to 2015, and the work was organized into four discipline-centric teams: external aerodynamics, internal aerodynamics, aeroelasticity, and hydrodynamics. This paper summarizes findings and lessons learned from the task group.

  2. Antitumor Effect of Measle Virus Strain Hu 191 on HeLa Cell Lines in vitro & in vivo Tests%麻疹病毒沪191对HeLa肿瘤细胞抑制作用的体内外实验研究

    Institute of Scientific and Technical Information of China (English)

    严银芳; 杨小清

    2012-01-01

    The therapeutic effect of measles virus Hu191 (MV191) on HeLa cell cultures and on nude mice bearing HeLa tumors was studied. Viral quantity in cells were assayed using plaque experiments- The cytotoxic effect of MV191 on HeLa cell in vitro was detected by MTT assay. The changes of cell cycle and apoptosis rate of HeLa cells infected by MV191 were assayed by flow cytometer. Subcutaneous HeLa tumor model were established in the hind flanks of nude mice and investigated antitumor activity of MV191 against HeLa xenografts in experiments in vivo. The results showed that widespread cytopathic effects (CPE) were observed on the monolayers of HeLa cell infected; The viability of HeLa cells infected have reduced obviously. The infection by MV 191 could cause G1 cells retardation in HeLa cells. The apoptosis rate of tumor cells increased obviously as compared with the untreated control cells. There was a significant suppression of tumor growth in MV191 treated intratumorally animals (P<0. 01) as compared with controls. Therefore, MV191 had potent antitumor activity against HeLa cell lines and its xenografts.%研究麻疹病毒减毒疫苗沪191株(MV沪191)在组织培养中和裸鼠体内对HeLa肿瘤细胞的抑制作用.用空斑实验测定MV沪191感染HeLa细胞后细胞裂解液中病毒量;用MTF试验测定MV沪191感染对细胞活性的影响;用流式细胞仪分析测定MV沪191感染引起的细胞凋亡和对细胞周期的影响;HeLa肿瘤细胞背部皮下接种BALB/C裸鼠引起的肿瘤,评估MV沪191体内抑瘤作用.MV沪191感染HeLa细胞后可引起广泛的CPE,感染的HeLa细胞与对照组相比细胞活性明显降低.MV沪191感染HeLa细胞后随着时间延长,G1/G0细胞率明显增多,S期率明显减少,细胞凋亡率明显增加(P<0.01).给药第60天时瘤内治疗组、静脉治疗组和对照组肿瘤体积平均分别为15.5、64.6、156.4 mm3.瘤内治疗组与对照组相比有显著差异(P<0.01);静脉治疗组与对

  3. CIRCUMSTANŢELE AGRAVANTE PREVĂZUTE LA lit.b ŞI d alin.(2 ŞI LA alin.(3 art.191 CP RM

    Directory of Open Access Journals (Sweden)

    Irina SELEVESTRU

    2016-03-01

    Full Text Available În rezultatul investigaţiei efectuate, se stabileşte că circumstanţa agravantă consemnată la lit.b alin.(2 art.191 CP RM nu este operaţională în următoarele două ipoteze: a infracţiunea prevăzută la alin.(1 art.191 CP RM este săvârşită de o persoană având calitatea specială de administrator, împreună cu o persoană care nu are o asemenea calitate; b infrac­ţiunea este comisă de o persoană având calitatea specială de administrator, prin intermediul unei persoane care nu are o astfel de calitate. Se relevă că, în situaţia în care decizia, care contravine dispoziţiei alin.(1 art.191 CP RM, este adoptată de doi sau mai mulţi membri ai unui organism decizional colegial, apare temeiul aplicării lit.b alin.(2 art.191 CP RM. Se arată că va răspunde în calitate de organizator, instigator sau complice la infracţiunea prevăzută la lit.d alin.(2 art.191 CP RM acea persoană: a căreia îi lipseşte fie cea de-a doua calitate specială nominalizată mai sus, fie ambele calităţi speciale menţionate supra şi b care a luat parte la comiterea respectivei infracţiuni. Se demonstrează că art.327 sau 335 CP RM ori art.312 din Codul contravenţional nu pot fi aplicate în ipoteza în care infracţiunea prevăzută la alin.(1 art.191 CP RM este săvârşită cu folosirea situaţiei de serviciu. THE AGGRAVATING CIRCUMSTANCES REFFERED TO AT lett.b AND d par.(2 AND par.(3 OF art.191 PC RMAs a result of the conducted investigation, it is established that the aggravating circumstance under lett.b par.(2 art.191 PC RM does not work in the following two assumptions: a the offence referred to at par.(1 art.191 PC RM is committed by a person with the special quality of manager, together with a person who does not have such a quality; b the offence is committed by a person with the special quality of manager, through a mediator who does not have such a quality. It is shown that, if the decision – contrary to par.(1 art

  4. Derivation of airfoil characteristics for the LM 19.1 blade based on 3D CFD rotor calculations

    Energy Technology Data Exchange (ETDEWEB)

    Bak, C.; Soerensen, N.N.; Madsen, H.A. [Risoe National Lab., Roskilde (Denmark)

    1999-03-01

    Airfoil characteristics for the LM 19.1 blade are derived from 3D CFD computations on a full-scale 41-m rotor. Based on 3D CFD the force distributions on the blades are determined, from which airfoil characteristics are derived using the momentum theory. The final airfoil characteristics are constructed using both wind tunnel measurements and 3D CFD. Compared to 2D wind tunnel measurements they show a low lift in stall for the airfoil sections at the tip. At the airfoil sections at the inner part of the blade, they show a high lift in stall. At about 60% radius the lift agrees well to 2D wind tunnel measurements. Aero-elastic calculations using the final airfoil characteristics show good agreement to measured power and flap moments. Furthermore, a fatigue load analysis shows a reduction of up to 15% of the load compared to commonly used data. (au)

  5. Differences in Biofilm Mass, Expression of Biofilm-Associated Genes, and Resistance to Desiccation between Epidemic and Sporadic Clones of Carbapenem-Resistant Acinetobacter baumannii Sequence Type 191

    Science.gov (United States)

    Selasi, Gati Noble; Nicholas, Asiimwe; Jeon, Hyejin; Na, Seok Hyeon; Kwon, Hyo Il; Kim, Yoo Jeong; Heo, Sang Taek; Oh, Man Hwan; Lee, Je Chul

    2016-01-01

    Understanding the biology behind the epidemicity and persistence of Acinetobacter baumannii in the hospital environment is critical to control outbreaks of infection. This study investigated the contributing factors to the epidemicity of carbapenem-resistant A. baumannii (CRAB) sequence type (ST) 191 by comparing the differences in biofilm formation, expression of biofilm-associated genes, and resistance to desiccation between major epidemic (n = 16), minor epidemic (n = 12), and sporadic (n = 12) clones. Biofilm mass was significantly greater in the major epidemic than the minor epidemic and sporadic clones. Major and minor epidemic clones expressed biofilm-associated genes, abaI, bap, pgaABCD, and csuA/BABCDE, higher than the sporadic clones in sessile conditions. The csuC, csuD, and csuE genes were more highly expressed in the major epidemic than minor epidemic clones. Interestingly, minor epidemic clones expressed more biofilm-associated genes than the major epidemic clone under planktonic conditions. Major epidemic clones were more resistant to desiccation than minor epidemic and sporadic clones on day 21. In conclusion, the epidemic CRAB ST191 clones exhibit a higher capacity to form biofilms, express the biofilm-associated genes under sessile conditions, and resist desiccation than sporadic clones. These phenotypic and genotypic characteristics of CRAB ST191 may account for the epidemicity of specific CRAB ST191 clones in the hospital. PMID:27622249

  6. Association between exposure to dioxin-like polychlorinated biphenyls and miR-191 expression in human peripheral blood mononuclear cells.

    Science.gov (United States)

    Guida, Maurizio; Marra, Maria Luisa; Marra, Marialuisa; Zullo, Fulvio; Guida, Marco; Trifuoggi, Marco; Biffali, Elio; Borra, Marco; De Mieri, Giovanna; D'Alessandro, Raffaella; De Felice, Bruna

    2013-04-30

    Accumulating evidence shows an association between deregulation of miRNAs and exposure to environmental chemicals; miRNAs play a unique regulatory role in gene expression. Among environmental pollutants, dioxins are a family of compounds that are known to have multiple hazardous effects. Also, in utero exposure of the fetus to dioxins has been shown to cause impaired psychomotor development, decreased immune function and skin disease. miR-191 is a microRNA that has been found to be up-regulated by dioxin in hepatocellular carcinoma cells in vitro. Our study provides the first molecular evidence in vivo of a positive relationship between levels of polychlorinated biphenyls (PCBs) and miR-191 expression in human peripheral blood mononuclear cells. miR-191 expression was significantly correlated with blood concentrations of total PCB and, in particular, of 3,3',4,4',5,5'-hexachlorobiphenyl (PCB 169, a coplanar congener). Blood concentrations of PCB 169 correlated significantly with miR-191 expression in pregnant women living in a PCB-polluted area, who underwent therapeutic abortion due to fetal malformations. These data suggest that miRNAs could be potential biomarkers to clarify the mechanisms of environmental disease.

  7. Production, purification and application of extracellular chitinase from Cellulosimicrobium cellulans 191 Produção, purificação e aplicação da quitinase extracelular de Cellulosimicrobium cellulans 191

    Directory of Open Access Journals (Sweden)

    Luciana F. Fleuri

    2009-09-01

    Full Text Available This study concerned the production, purification and application of extracellular chitinase from Cellulosimicrobium cellulans strain 191. In shaken flasks the maximum yield of chitinase was 6.9 U/mL after 72 h of cultivation at 25ºC and 200 rpm. In a 5 L fermenter with 1.5 vvm aeration, the highest yield obtained was 4.19 U/mL after 168 h of fermentation at 25ºC and 200 rpm, and using 3 vvm, it was 4.38 U/mL after 144 h of fermentation. The chitinase (61 KDa was purified about 6.65 times by Sepharose CL 4B 200 gel filtration with a yield of 46.61%. The purified enzyme was able to lyse the cell walls of some fungi and to form protoplasts.O presente estudo visou a produção, purificação e aplicação da quitinase extracelular da linhagem Cellulosimicrobium cellulans 191. A maior produção de quitinase em frascos agitados foi 6,9 U/mL após 72 h de fermentação a 25ºC e 200 rpm. Em fermentador de 5 L utilizando aeração de 1,5 vvm, a maior atividade da enzima foi 4,19 U/mL após 168 h de fermentação a 25ºC e 200 rpm; e com 3 vvm, foi obtido 4,38 U/mL após 144 h de fermentação. A quitinase (61 KDa foi purificada cerca de 6,65 vezes em coluna de filtração em gel Sepharose CL 4B 200 com um rendimento de 46,61%. A enzima purificada foi capaz de lisar a parede celular de alguns fungos e formar protoplastos.

  8. Constitutional rights to health, public health and medical care: the status of health protections in 191 countries.

    Science.gov (United States)

    Heymann, Jody; Cassola, Adèle; Raub, Amy; Mishra, Lipi

    2013-07-01

    United Nations (UN) member states have universally recognised the right to health in international agreements, but protection of this right at the national level remains incomplete. This article examines the level and scope of constitutional protection of specific rights to public health and medical care, as well as the broad right to health. We analysed health rights in the constitutions of 191 UN countries in 2007 and 2011. We examined how rights protections varied across the year of constitutional adoption; national income group and region; and for vulnerable groups within each country. A minority of the countries guaranteed the rights to public health (14%), medical care (38%) and overall health (36%) in their constitutions in 2011. Free medical care was constitutionally protected in 9% of the countries. Thirteen per cent of the constitutions guaranteed children's right to health or medical care, 6% did so for persons with disabilities and 5% for each of the elderly and the socio-economically disadvantaged. Valuable next steps include regular monitoring of the national protection of health rights recognised in international agreements, analyses of the impact of health rights on health outcomes and longitudinal multi-level studies to assess whether specific formulations of the rights have greater impact.

  9. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

    Directory of Open Access Journals (Sweden)

    Ping Yang

    2016-09-01

    Full Text Available Taxifolin is a ubiquitous bioactive constituent of foods and herbs. To thoroughly explore its metabolism in vivo, an HPLC-ESI-IT-TOF-MSn method combined with specific metabolite detection strategy was used to detect and identify the metabolites of taxifolin in rats. Of the 191 metabolites tentatively identified, 154 were new metabolites, 69 were new compounds and 32 were dimers. This is the first report of the in vivo biotransformation of a single compound into more than 100 metabolites. Furthermore, acetylamination and pyroglutamic acid conjugation were identified as new metabolic reactions. Seventeen metabolites were found to have various taxifolin-related bioactivities. The potential targets of taxifolin and 63 metabolites were predicted using PharmMapper, with results showing that more than 60 metabolites have the same five targets. Metabolites with the same fragment pattern may have the same pharmacophore. Thus these metabolites may exert the same pharmacological effects as taxifolin through an additive effect on the same drug targets. This observation indicates that taxifolin is bioactive not only in the parent form, but also through its metabolites. These findings enhance understanding of the metabolism and effective forms of taxifolin and may provide further insight of the beneficial effects of taxifolin and its derivatives.

  10. The phenotype of polycythemia due to Croatian homozygous VHL (571C>G:H191D) mutation is different from that of Chuvash polycythemia (VHL 598C>T:R200W)

    Science.gov (United States)

    Tomasic, Nikica Ljubas; Piterkova, Lucie; Huff, Chad; Bilic, Ernest; Yoon, Donghoon; Miasnikova, Galina Y.; Sergueeva, Adelina I.; Niu, Xiaomei; Nekhai, Sergei; Gordeuk, Victor; Prchal, Josef T.

    2013-01-01

    Mutations of VHL (a negative regulator of hypoxia-inducible factors) have position-dependent distinct cancer phenotypes. Only two known inherited homozygous VHL mutations exist and they cause polycythemia: Chuvash R200W and Croatian H191D. We report a second polycythemic Croatian H191D homozygote distantly related to the first propositus. Three generations of both families were genotyped for analysis of shared ancestry. Biochemical and molecular tests were performed to better define their phenotypes, with an emphasis on a comparison with Chuvash polycythemia. The VHL H191D mutation did not segregate in the family defined by the known common ancestors of the two subjects, suggesting a high prevalence in Croatians, but haplotype analysis indicated an undocumented common ancestor ∼six generations ago as the founder of this mutation. We show that erythropoietin levels in homozygous VHL H191D individuals are higher than in VHL R200W patients of similar ages, and their native erythroid progenitors, unlike Chuvash R200W, are not hypersensitive to erythropoietin. This observation contrasts with a report suggesting that polycythemia in VHL R200W and H191D homozygotes is due to the loss of JAK2 regulation from VHL R200W and H191D binding to SOCS1. In conclusion, our studies further define the hematologic phenotype of VHL H191D and provide additional evidence for phenotypic heterogeneity associated with the positional effects of VHL mutations. PMID:23403324

  11. Implementation of the Resource Disincentive in 40 CFR part 191.14 (e) at the Waste Isolation Pilot Plant. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    In 1986, the US Department of Energy (DOE) Waste Isolation Pilot Plant (WIPP) Project Office (WPO) (DOE-WPO) prepared a strategy for complying with the Environmental Protection Agency`s (EPA`s) Standards for the management of transuranic (TRU) waste. Section 3.2.2.2 of the DOE`s report addressed compliance with the Assurance Requirements found in 40 CFR {section} 191.14. One of the Assurance Requirements addresses the selection of repository sites that contain recoverable natural resources. This report documents that the site selection process for the WIPP facility did indeed comply with the natural resource disincentive requirement in 40 CFR {section} 191,14(e) at the time selected and therefore complies with the standard at this time. Thus, it shall be shown that it is reasonably certain that the WIPP site provides better overall protection than practical alternatives that were available when the site was selected. It is important to point out here, and it will be discussed later in the report, that the resource disincentive requirement is a preliminary siting criterion that requires further evaluation of sites that have resources (i.e, hydrocarbons, minerals and groundwater) in the vicinity or on the site. This further evaluation requires that for sites that do have resources, a qualitative determination must be made that the site will provide better overall protection than practical alternatives. The purpose of this report is not to provide a quantitative evaluation for selection of the WIPP site. A further discussion on the difference between the qualitative analysis required under 40 CFR {section} 191.14(e) and the quantitative analysis under other sections of 40 CFR 191 is provided in {section}2.1 of this report.

  12. Draft forecast of the final report for the comparison to 40 CFR Part 191, Subpart B, for the Waste Isolation Pilot Plant

    Energy Technology Data Exchange (ETDEWEB)

    Bertram-Howery, S.G.; Marietta, M.G.; Anderson, D.R.; Gomez, L.S.; Rechard, R.P. (Sandia National Labs., Albuquerque, NM (USA)); Brinster, K.F.; Guzowski, R.V. (Science Applications International Corp., Albuquerque, NM (USA))

    1989-12-01

    The United States Department of Energy is planning to dispose of transuranic wastes, which have been generated by defense programs, at the Waste Isolation Pilot Plant. The WIPP Project will assess compliance with the requirements of the United States Environmental Protection Agency. This report forecasts the planned 1992 document, Comparison to 40 CFR, Part 191, Subpart B, for the Waste Isolation Pilot Plant (WIPP). 130 refs., 36 figs., 11 tabs.

  13. Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Volume 4: Uncertainty and sensitivity analyses for 40 CFR 191, Subpart B

    Energy Technology Data Exchange (ETDEWEB)

    1993-08-01

    Before disposing of transuranic radioactive waste in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for a final compliance evaluation. This volume of the 1992 PA contains results of uncertainty and sensitivity analyses with respect to the EPA`s Environmental Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B). Additional information about the 1992 PA is provided in other volumes. Results of the 1992 uncertainty and sensitivity analyses indicate that, conditional on the modeling assumptions, the choice of parameters selected for sampling, and the assigned parameter-value distributions, the most important parameters for which uncertainty has the potential to affect compliance with 40 CFR 191B are: drilling intensity, intrusion borehole permeability, halite and anhydrite permeabilities, radionuclide solubilities and distribution coefficients, fracture spacing in the Culebra Dolomite Member of the Rustler Formation, porosity of the Culebra, and spatial variability of Culebra transmissivity. Performance with respect to 40 CFR 191B is insensitive to uncertainty in other parameters; however, additional data are needed to confirm that reality lies within the assigned distributions.

  14. Efficacy and safety of oral citicoline in acute ischemic stroke: drug surveillance study in 4,191 cases.

    Science.gov (United States)

    Cho, H-J; Kim, Y J

    2009-04-01

    Citicoline is an essential precursor in the synthesis of phosphatidylcholine, a key cell membrane phospholipid, and is known to have neuroprotective effects in acute ischemic stroke. The aim of this study was to determine the efficacy and safety of oral citicoline in Korean patients with acute ischemic stroke. A drug surveillance study was carried out in 4,191 patients with a diagnosis of acute ischemic stroke. Oral citicoline (500-4000 mg/day) was administered within less than 24 h after acute ischemic stroke in 3,736 patients (early group) and later than 24 h after acute ischemic stroke in 455 patients (late group) for at least 6 weeks. For efficacy assessment, primary outcomes were patients' scores obtained with a short form of the National Institutes of Health Stroke Scale (s-NIHSS), a short form of the Barthel Index of activities of daily living (s-BI) and a modified Rankin Scale (mRS) at enrollment, after 6 weeks and at the end of therapy for those patients with extended treatment. All adverse reactions were monitored during the study period for safety assessment. All measured outcomes, including s-NIHSS, s-BI and mRS, were improved after 6 weeks of therapy (P citicoline therapy for more than 12 weeks when compared with those who ended therapy at week 6. Improvements were more significant in the higher dose group (> or = 2000 mg/day) (P Citicoline safety was excellent; 37 side effects were observed in 31 patients (0.73%). The most frequent findings were nervous system-related symptoms (8 of 37, 21.62%), followed by gastrointestinal symptoms (5 of 37, 13.5%). Oral citicoline improved neurological, functional and global outcomes in patients with acute ischemic stroke without significant safety concerns.

  15. 麻疹病毒疫苗株沪191和宁波麻疹病毒流行株血清交叉中和试验结果分析%Study on the Cross Neutralizing Antibody between Measles Attenuated Live Vaccine S191 and the Measles Epidemic Strain in Ningbo

    Institute of Scientific and Technical Information of China (English)

    傅燕; 许国章; 董红军; 胡逢蛟; 马瑞; 陆圣诞; 焦素黎

    2013-01-01

    Objective To analyze the protective level of the current measles vaccine (Shanghai 191. S191) and provide evidence for formulating effective strategies of measles prevention. Methods Neutralizing antibody levels to measles vaccine virus strain S191 and wild type virus strain Ningbo2008-06 from different kinds person' s serum were tested by trace neutralization test. Results The geometric mean titer(GMT)to S191 of primarily vaccination serum, acute phase serum of patients immunized with measles vaccine, serum of convalescence patients, serum of pre-emergency vaccination and serum of post-emergency vaccination werel :35.23,:4.16,: 231.74, : 37.81 and 1:61.03 respectively ;while the GMT to Ningbo 2008-06 of the above serum were 1:19.04,: 2.21,: 596.62,: 32.25 and 1:67.54 respectively. The GMT of the serum of primarily vaccine immunization and the serum of acute phase patients against S191 were 1.85 (t=2.537, P<0.05)and 1.88(t=-2.696, P<0.05) times of those against Ningbo 2008-06 respectively. The GMT of the serum of convalescence patients against Ningbo 2008-06 was 2.57 (t=-3.054, P<0.05) times of that against S191.There was no significant difference between the GMT against S191 and Ningbo2008-06 in post-emergency vaccination serum. For infants, their serum' s GMT against S191 and Ningbo2008-06 declined with their growing up. The GMT against Ningbo2008-06 in 6months and 8months old group were 1:2.60 and 1:1.24 respectively. Conclusions The current measles vaccine S191 can neutraliae Ningbo2008-06,but the neutralizing ability decreased. Emergency vaccination can significantly increasebody s neutralization antibody titer to measles. The antibody from mother almost has no protection after 6 months. It is the time to revise current measles immunization strategies.%目的 分析麻疹病毒疫苗株[上海(沪)191,Shanghai191;S191]的免疫保护性,为探讨有效预防控制麻疹的措施提供参考.方法 用微量中和试验测定不同人群血清

  16. Baicalin protects against TNF-α-induced injury by down-regulating miR-191a that targets the tight junction protein ZO-1 in IEC-6 cells.

    Science.gov (United States)

    Wang, Li; Zhang, Ren; Chen, Jian; Wu, Qihui; Kuang, Zaoyuan

    2017-01-20

    TNF-α plays an important role in the developing process of inflammatory bowel disease. Tight junction protein zonula occludens-1 (ZO-1), one of epithelial junctional proteins, maintains the permeability of intestinal barrier. The objective of this study was to investigate the mechanism of the protective effect of baicalin on TNF-α-induced injury and ZO-1 expression in intestinal epithelial cells (IECs). We found that baicalin pretreatment significantly improved cell viability and cell migration following TNF-α stimulation. MiR-191a inhibitor increased the protective effect of baicalin on cell motility injured by TNF-α. In addition, miR-191a down-regulated the mRNA and protein level of its target gene ZO-1. TNF-α stimulation increased miR-191a expression, leading to the decline of ZO-1 mRNA and protein. Moreover, pretreatment with baicalin reversed TNF-α induced decrease of ZO-1 and increase of miR-191a, miR-191a inhibitor significantly enhanced ZO-1 protein expression restored by baicalin. These results indicate that baicalin exerts a protective effect on IEC-6 cells against TNF-α-induced injury, which is at least partly via inhibiting the expression of miR-191a, thus increasing ZO-1 mRNA and protein levels.

  17. Cloning of a Plasma Membrane Protein Gene TaPM19-1 and Its Response to Abiotic Stresses in Wheat%小麦质膜蛋白基因TaPM19-1的克隆及其对非生物胁迫的响应

    Institute of Scientific and Technical Information of China (English)

    李永春; 张春艳; 张宁; 孟凡荣; 任江萍; 牛洪斌; 王翔; 尹钧

    2012-01-01

    [目的]分析小麦质膜蛋白基因TaPM19-1的特征及其对非生物胁迫的响应,并探讨其在小麦抗逆调控过程中的生物学功能.[方法]利用RACE技术克隆了该基因cDNA全长,采用生物信息学方法分析克隆基因编码蛋白的特性,并通过半定量RT-PCR分析该基因在非生物胁迫条件下的表达特性.[结果]TaPM19-1的cDNA全长1090 bp,无内含子,编码蛋白包含182个氨基酸,分子量为19.02 kD,包含有典型的AWPM19保守域;依据氨基酸序列将来源于不同植物的16个AWPM19类蛋白分为3组,TaPM19-1与2个来源于大麦及1个二穗短柄草的AWPM19类蛋白亲源关系最近,同属于第三组.高级结构分析显示,TaPM19-1可形成4个由α-螺旋组成的跨膜域,N端位于膜内,包含由27个氨基酸组成的信号肽,C端近40个氨基酸位于膜内.表达分析显示,TaPM19-1除在发育后期的种子中有较高水平表达外,其它组织中未检测到表达;在所检测的2个小麦品种根系中,TaPM19-1的表达受ABA诱导,但在叶片中的表达量极低;水分胁迫条件下,该基因在根系和叶片中均呈现较强的诱导表达特性;在高盐和高温胁迫条件下,该基因在洛旱2号小麦中均可诱导表达,而在中国春小麦中未检测到该基因表达;在低温胁迫条件下,未检测到TaPM19-1的表达.[结论]获得了小麦质膜蛋白基因TaPM19-1的cDNA 全长,其编码蛋白可形成典型的跨膜结构特征;该基因受植物激素ABA的诱导,在洛旱2号中也可被干旱、高盐和高温胁迫诱导,但在中国春中对高盐和高温胁迫无响应.推测TaPM19-1在洛旱2号和中国春中存在不同的转录调控机制.%[Objective] The characteristics of a plasma membrane protein gene TaPM19-1 and its response to abiotic stresses in wheat were studied, which will provide an insight into its biological roles involved in the molecular mechanisms of abiotic-sterss response in wheat. [Method] RACE technology was

  18. Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: A model for identifying candidate breast-tumor suppressors

    Directory of Open Access Journals (Sweden)

    Matsui Sei-Ichi

    2008-06-01

    Full Text Available Abstract Background Widely accepted somatic mutation theory of carcinogenesis states that mutations in oncogenes and tumor suppressor genes in genomes of somatic cells is the cause of neoplastic transformation. Identifying frequent mutations in cancer cells suggests the involvement of mutant genes in carcinogenesis. Results To develop an in vitro model for the analysis of genetic alterations associated with breast carcinogenesis, we used random mutagenesis and selection of human non-tumorigenic immortalized breast epithelial cells MCF-10A in tissue-culture conditions that mimic tumor environment. Random mutations were generated in MCF-10A cells by cultivating them in a tissue-culture medium containing the frameshift-inducing agent ICR191. The first selective condition we used to transform MCF1-10A cells was cultivation in a medium containing mutagen at a concentration that allowed cell replication despite p53 protein accumulation induced by mutagen treatment. The second step of selection was either cell cultivation in a medium with reduced growth-factor supply or in a medium that mimics a hypoxia condition or growing in soft agar. Using mutagenesis and selection, we have generated several independently derived cultures with various degrees of transformation. Gene Identification by Nonsense-mediated mRNA decay Inhibition (GINI analysis has identified the ICR191-induced frameshift mutations in the TP53, smoothelin, Ras association (RalGDS/AF-6 domain family 6 (RASSF6 and other genes in the transformed MCF-10A cells. The TP53 gene mutations resulting in the loss of protein expression had been found in all independently transformed MCF-10A cultures, which form large progressively growing tumors with sustained angiogenesis in nude mice. Conclusion Identifying genes containing bi-allelic ICR191-induced frameshift mutations in the transformed MCF-10A cells generated by random mutagenesis and selection indicates putative breast-tumor suppressors. This

  19. Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Volume 1, Third comparison with 40 CFR 191, Subpart B

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-01

    Before disposing of transuranic radioactive wastes in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments of the WIPP for the DOE to provide interim guidance while preparing for final compliance evaluations. This volume contains an overview of WIPP performance assessment and a preliminary comparison with the long-term requirements of the Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B).

  20. Analysis of ultraviolet and extreme-ultraviolet spectra of the DA white dwarf G 191-B2B using self-consistent diffusion models

    Science.gov (United States)

    Dreizler, S.; Wolff, B.

    1999-08-01

    We present a multi-wavelength spectral analysis of the DA white dwarf G 191-B2B. The employed atmospheric models account for gravitational settling and radiative levitation, which are, for the first time, calculated self-consistently with the atmospheric structure. The resulting spectra can reproduce the complete EUVE spectrum and the ultraviolet lines of iron. Some restrictions regarding the UV lines of other elements (C, N, O, Ni), however, still remain. In contrast to homogeneous models, it is not necessary to introduce additional photospheric or interstellar absorbers to account for the high opacity at lambda Research in Astronomy, Inc. under NASA contract NAS 5-26555.

  1. Nuclear spins of the isomers /sup 191m-185m/Hg determined by on-line quantum-beat spectroscopy

    CERN Document Server

    Kremmling, H; Fischer, H G; Kluge, H J; Kühl, T; Schüssler, H A

    1979-01-01

    The nuclear spins of the very neutron-deficient /sup 191m-185m/Hg isomers were measured on line at the mass separator ISOLIDE at CERN using pulsed-laser excitation and observation of the time-resolved quantum beats from selected hyperfine-structure states. The spins of these isomers are with I=13/2 equal to those of the long-lived isomers /sup 199m-193m/Hg already known. The persistence of this spin value for eight isomers is explained by the model of rotation-aligned coupling. (12 refs).

  2. Analysis of Chinese Ecommerce Website Profit model--A Case Study in 191 E-commerce Sites%浅析中国电子商务网站盈利模式--以191电子商务网站为例

    Institute of Scientific and Technical Information of China (English)

    成淼

    2014-01-01

    进入21世纪后,电子商务被广泛应用于经济领域中,它已逐渐成为了商家从事商业活动的新模式,而电子商务网站的盈利模式也越来越多样化。主要探讨了191电子商务网站的盈利模式,并对其提出了改善建议。%In the 21st century, E-commerce is widely used in the economic sphere, it has gradually become a new model for businesses engaged in commercial activities, and E-commerce sites are increasingly diversified revenue model. 191 E-commerce sites focus on profit model, and its recommendations for improvement.

  3. 麻疹病毒沪-191株在鸡胚成纤维细胞中连续传代的遗传稳定性%Genetic stability of measles virus Shanghai-191 strain after continuous subculture in chick embryo fibroblasts

    Institute of Scientific and Technical Information of China (English)

    杨会强; 康庄; 倪谦枝; 刘宇虹; 温雪如; 刘瑛; 雍雪飞; 刘杰; 孙艳

    2013-01-01

    目的 研究麻疹病毒沪-191株在鸡胚成纤维细胞中连续传代的遗传稳定性.方法 将麻疹病毒沪-191株原始种子批(P25)在鸡胚成纤维细胞上传代2次(P27)作为主种子批,继续传代3次(P30)作为工作种子批,继续传代至33(P33)和35(P35)代.对P25、P27、P30、P33和P35病毒基因组进行基因序列分析,并对所有代次病毒进行滴度测定.结果 麻疹病毒沪-191株在鸡胚成纤维细胞中从25代传至35代,其滴度维持在5.0~5.875 lgCCID50/ml之间;P25、P27 、P30、P33、P35 5个代次病毒的全基因组序列未发生任何核苷酸和氨基酸改变.结论 麻疹病毒沪-191株在鸡胚成纤维细胞连续传代,病毒滴度均一,基因组序列未发生改变,遗传稳定性良好.%Objective To investigate the genetic stability of measles virus Shanghai-191 strain after continuous subculture in chick embryo fibroblasts. Methods The seeds from primary seed lot of measles virus Shanghai-191 strain (P25) strain was subcultured in chick embryo fibroblasts for two passages (P27) and used as mater seed lot, for further three passages (P30) as working seed lot, and further subcultured to passages 33 (P33) and 35 (P35). The genome of various passages were sequenced, while the titers were determined. Results The titer of Shanghai-191 strain from P25 to P35 were maintained at 5. 0 ~ 5. 875 lgCCID50/ml. No any change of nucleotides or amino acids were observed in genomes P25, P27, P30, P33 and P35. Conclusion The titer of measles virus Shanghai-191 strain was stable after continuous subculture in chick embryo fibroblasts, while the genome sequence showed no change, indicating high genetic stability of the strain.

  4. Stellar laboratories. VI. New Mo IV - VII oscillator strengths and the molybdenum abundance in the hot white dwarfs G191-B2B and RE0503-289

    CERN Document Server

    Rauch, T; Hoyer, D; Werner, K; Demleitner, M; Kruk, J W

    2015-01-01

    For the spectral analysis of high-resolution and high-signal-to-noise (S/N) spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. To identify molybdenum lines in the ultraviolet (UV) spectra of the DA-type white dwarf G191-B2B and the DO-type white dwarf RE0503-289 and to determine their photospheric Mo abundances, newly calculated Mo IV - VII oscillator strengths are used. We identified twelve Mo V and nine Mo VI lines in the UV spectrum of RE0503-289 and measured a photospheric Mo abundance of 1.2 - 3.0 x 10**-4 (mass fraction, 22500 - 56400 times the solar abundance). In addition, from the As V and Sn IV resonance lines, we measured mass fractions of arsenic (0.5 - 1.3 x 10**-5, about 300 - 1200 times solar) and tin (1.3 - 3.2 x 10**-4, about 14300 35200 times solar). For G191-B2B, upper limits were determined for the abundances of Mo (5.3 x 10*...

  5. Judd-Oflet analysis of spectrum and laser performance of Ho:YAP crystal end-pumped by 1.91-μm Tm:YLF laser

    Institute of Scientific and Technical Information of China (English)

    Yao Bao-Quan; Zheng Liang-Liang; Yang Xiao-Tao; Wang Tian-Heng; Duan Xiao-Ming; Zhao Guang-Jun; Dong Qin

    2009-01-01

    The Ho: YAP crystal is grown by the Czochralski technique. The room-temperature polarized absorption spectra of Ho: YAP crystal was measured on a c-cut sample with 1 at% holmium. According to the obtained Judd-Ofelt intensity parameters Ω2 = 1.42 × 10-20cm2, Ω4 = 2.92 × 10-20cm2, and Ω6 = 1.71 × 10-20cm2, this paper calculated the fluorescence lifetime to be 6 ms for 5I7→5 transition, and the integrated emission cross section to be 2.24× 10-18 cm2. It investigates the room-temperature Ho:YAP laser end-pumped by a 1.91-μm Tm:YLF laser. The maximum output power was 4.1 W when the incident 1.91-μm pump power was 14.4 W. The slope efficiency is 40.8%, corresponding to an optical-to-optical conversion efficiency of 28.4%. The Ho: YAP output wavelength was centred at 2118 ran with full width at half maximum of about 0.8 nm.

  6. ECHELLE SPECTROSCOPY OF THE NUCLEI OF THE HIGHLY COLLIMATED BIPOLAR PLANETARY NEBULAE M 2-9 AND M 1-91

    Directory of Open Access Journals (Sweden)

    S. Torres-Peimbert

    2010-01-01

    Full Text Available Presentamos espectroscopía echelle del núcleo sin resolver de las nebulosas bipolares M 2-9 and M 1-91. Los espectros están dominados por líneas de emisión emitidas en un amplio intervalo de condiciones físicas. De las observaciones identificamos las líneas de emisión, las condiciones físicas y los movimientos relativos de las diferentes especies ionizadas en la región circunestelar de ambos objetos. Proponemos que las líneas prohibidas observadas se originan en la parte interior del toro extendido que rodea a cada objeto.

  7. Searches for neutral Higgs bosons in $e^+ e^-$ collisions from $\\sqrt{s}$ = 191.6 to 201.7 GeV

    CERN Document Server

    Abdallah, J; Adam, W; Adzic, P; Albrecht, T; Alderweireld, T; Alemany-Fernandez, R; Allmendinger, T; Allport, P P; Almehed, S; Amaldi, Ugo; Amapane, N; Amato, S; Anashkin, E; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W D; Arnoud, Y; Ask, S; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Ballestrero, A; Bambade, P; Barbier, R; Bardin, Dimitri Yuri; Barker, G; Baroncelli, A; Battaglia, Marco; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Bellunato, T F; Benekos, N C; Benvenuti, Alberto C; Bérat, C; Berggren, M; Berntzon, L; Bertrand, D; Besançon, M; Besson, N; Bloch, D; Blom, M; Bonesini, M; Boonekamp, M; Booth, P S L; Borisov, G; Botner, O; Bouquet, B; Bowcock, T J V; Boyko, I; Bracko, M; Brenner, R; Brodet, E; Brodzicka, J; Brückman, P; Brunet, J M; Bugge, L; Buschmann, P; Calvi, M; Camporesi, T; Canale, V; Carena, F; Carimalo, C; Castro, N; Cavallo, F R; Chapkin, M M; Charpentier, P; Checchia, P; Chierici, R; Shlyapnikov, P; Chung, S U; Cieslik, K; Collins, P; Contri, R; Cosme, G; Cossutti, F; Costa, M J; Crawley, B; Crennell, D J; Cuevas-Maestro, J; D'Hondt, J; Dalmau, J; Da Silva, T; Da Silva, W; Della Ricca, G; De Angelis, A; de Boer, Wim; De Clercq, C; De Lotto, B; De Maria, N; De Min, A; De Paula, L S; Di Ciaccio, Lucia; Di Simone, A; Doroba, K; Drees, J; Dris, M; Eigen, G; Ekelöf, T J C; Ellert, M; Elsing, M; Espirito-Santo, M C; Fanourakis, G K; Fassouliotis, D; Feindt, Michael; Fernández, J; Ferrer, A; Ferro, F; Flagmeyer, U; Föth, H; Fokitis, E; Fulda-Quenzer, F; Fuster, J A; Gandelman, M; García, C; Gavillet, P; Gazis, E N; Gelé, D; Geralis, T; Gokieli, R; Golob, B; Gómez-Ceballos, G; Gonçalves, P; Graziani, E; Grosdidier, G; Grzelak, K; Guy, J; Haag, C; Hahn, F; Hahn, S; Hallgren, A; Hamacher, K; Hamilton, K; Hansen, J; Haug, S; Hauler, F; Hedberg, V; Hennecke, M; Herr, H; Holmgren, S O; Holt, P J; Houlden, M A; Hultqvist, K; Jackson, J N; Jalocha, P; Jarlskog, C; Jarlskog, G; Jarry, P; Jeans, D; Johansson, E K; Johansson, P D; Jonsson, P; Joram, C; Jungermann, L; Kapusta, F; Katsanevas, S; Katsoufis, E C; Keränen, R; Kernel, G; Kersevan, Borut P; Kiiskinen, A P; King, B T; Kjaer, N J; Kluit, P M; Kokkinias, P; Kourkoumelis, C; Kuznetsov, O; Krumshtein, Z; Kucharczyk, M; Kurowska, J; Laforge, B; Lamsa, J; Leder, Gerhard; Ledroit, F; Leinonen, L; Leitner, R; Lemonne, J; Lenzen, Georg; Lepeltier, V; Lesiak, T; Liebig, W; Liko, D; Lipniacka, A; Lopes, J H; López, J M; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J N; Malek, A; Maltezos, S; Mandl, F; Marco, J; Marco, R; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Martínez-Rivero, C; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Mazzucato, F; Mazzucato, M; McNulty, R; Meroni, C; Meyer, W T; Migliore, E; Mitaroff, Winfried A; Mjörnmark, U; Moa, T; Moch, M; Mönig, K; Monge, R; Montenegro, J; Moraes, D; Moreno, S; Morettini, P; Müller, U; Münich, K; Mulders, M; Mundim, L M; Murray, W; Muryn, B; Myatt, Gerald; Myklebust, T; Nassiakou, M; Navarria, Francesco Luigi; Nawrocki, K; Némécek, S; Nicolaidou, R; Niezurawski, P; Nikolenko, M; Nygren, A; Oblakowska-Mucha, A; Obraztsov, V F; Olshevskii, A G; Onofre, A; Orava, Risto; Österberg, K; Ouraou, A; Oyanguren, A; Paganoni, M; Paiano, S; Palacios, J P; Palka, H; Papadopoulou, T D; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Peralta, L; Perepelitsa, V F; Perrotta, A; Petrolini, A; Piedra, J; Pieri, L; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Poireau, V; Pol, M E; Polok, G; Poropat, P; Pozdnyakov, V; Privitera, P; Pukhaeva, N; Pullia, Antonio; Rames, J; Ramler, L; Read, A; Rebecchi, P; Rehn, J; Reid, D; Reinhardt, R; Renton, P B; Richard, F; Rídky, J; Ripp-Baudot, I; Rodríguez, D; Romero, A; Ronchese, P; Rosenberg, E I; Roudeau, Patrick; Rovelli, T; Ruhlmann-Kleider, V; Ryabtchikov, D; Sadovskii, A; Salmi, L; Salt, J; Savoy-Navarro, Aurore; Schwanda, C; Schwering, B; Schwickerath, U; Segar, A; Sekulin, R L; Siebel, M; Sissakian, A N; Smadja, G; Smirnova, O G; Sokolov, A; Sopczak, André; Sosnowski, R; Spassoff, Tz; Stanitzki, M; Stocchi, A; Strauss, J; Stugu, B; Szczekowski, M; Szeptycka, M; Szumlak, T; Tabarelli de Fatis, T; Taffard, A C; Tegenfeldt, F; Terranova, F; Timmermans, J; Tinti, N; Tkatchev, L G; Tobin, M; Todorovova, S; Tomé, B; Tonazzo, A; Tortosa, P; Travnicek, P; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Tyapkin, I A; Tyapkin, P; Tzamarias, S; Ullaland, O; Uvarov, V; Valenti, G; van Dam, P; Van Eldik, J; Van Lysebetten, A; Van Remortel, N; Van Vulpen, I B; Vegni, G; Veloso, F; Venus, W A; Verbeure, F; Verdier, P; Verzi, V; Vilanova, D; Vitale, L; Vrba, V; Wahlen, H; Washbrook, A J; Weiser, C; Wicke, D; Wickens, J H; Wilkinson, G R; Winter, M; Witek, M; Yushchenko, O P; Zalewska-Bak, A; Zalewski, Piotr; Zavrtanik, D; Zimin, N I; Zinchenko, A I; Zoller, P; Zupan, M

    2002-01-01

    Neutral Higgs bosons of the Standard Model ({\\sc SM}) and the Minimal Supersymmetric Standard Model ({\\sc MSSM}) were searched for in the data collected in 1999 by the DELPHI experiment at centre-of-mass energies between 191.6 and 201.7~GeV with a total integrated luminosity of 228 pb$^{-1}$. These analyses, in combination with our results at lower energies, set 95\\% confidence level lower mass bounds on the Standard Model Higgs boson (107.3~GeV/$c^2$) and on the lightest neutral scalar (85.9~GeV/$c^2$) and neutral pseudoscalar (86.5~GeV/$c^2$) Higgs bosons in representative scans of the {\\sc MSSM} parameter space. % excluding $\\tan\\beta$ in the range [0.9-1.6] An extended scan of the {\\sc MSSM} parameter space was also performed to test the robustness of these limits.

  8. 3191例传染病医院感染的分析及对策%Analysis on 3 191 cases of nosocomial infectious disease in infectious hospital

    Institute of Scientific and Technical Information of China (English)

    张桂; 冉俐

    2002-01-01

    @@ 随着医学科学的发展及医疗护理质量的不断提高,医院对院内感染问题越来越重视.医院感染对重症病人危害极大,它不仅给病人带来痛苦,甚至导致死亡,还给病人单位、家庭在经济、身心上都带来重大负担,从而引起了医护人员的高度重视.本文对南京市2家医院收治的3 191例传染病患者进行了回顾性分析,现报告如下.

  9. Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia

    Science.gov (United States)

    de Mendonça Belmont, Taciana Furtado; do Ó, Kleyton Palmeira; Soares da Silva, Andreia; de Melo Vilar, Kamila; Silva Medeiros, Fernanda; Silva Vasconcelos, Luydson Richardson; Mendonça dos Anjos, Ana Claudia; Domingues Hatzlhofer, Betânia Lucena; Pitta, Maíra Galdino da Rocha; Bezerra, Marcos André Cavalcanti; Araújo, Aderson da Silva; de Melo Rego, Moacyr Jesus Barreto; Moura, Patrícia; Cavalcanti, Maria do Socorro Mendonça

    2016-01-01

    Introduction Patients with sickle cell anemia (SCA) may present chronic hemolytic anemia, vaso-occlusion and respiratory tract infection (RTI) episodes. Galectin-3 (GAL-3) is a multifunctional protein involved in inflammation, apoptosis, adhesion and resistance to reactive oxygen species. Studies point to a dual role for GAL-3 as both a circulation damage-associated molecular pattern and a cell membrane associated pattern recognition receptor. Objective To investigate associations between the SNPs of GAL-3 gene (LGALS3) and serum levels with RTI and vaso-occlusive crisis (VOC) in children with SCA. Materials and Methods SNPs +191 and +292 in LGALS3 were studied using the TaqMan real-time PCR system; GAL-3 serum levels were measured by ELISA. The study included 79 children with SCA ranging from 2 to 12 years old. Results GAL-3 serum levels were associated with LGALS3 +191 and +292 genotypes (p <0.0001; p = 0.0169, respectively). LGALS3 +191, AA genotype was associated with low and CC with higher levels of GAL-3. For LGALS3 +292, the CC genotype was associated with lower GAL-3 and AA with higher levels. Patients with Frequency of RTI (FRTI) ≥1 presented higher frequency of +191AA (p = 0.0263) and +292AC/CC genotypes (p = 0.0320). SNP +292 was associated with Frequency of VOC (FVOC) (p = 0.0347), whereas no association was shown with SNP +191 and FVOC. However, CA/AC and AA/CC genotypes with lower GAL-3 levels showed a higher frequency in patients with FRTI ≥1 (p = 0.0170; p = 0.0138, respectively). Also, patients with FVOC ≥1 presented association with CA/AC (p = 0.0228). LGALS3 +191 and +292 combined genotypes related to low (p = 0.0263) and intermediate expression (p = 0.0245) were associated with FRTI ≥1. Lower GAL-3 serum levels were associated with FRTI ≥1 (p = 0.0426) and FVOC ≥1 (p = 0.0012). Conclusion Variation of GAL-3 serum levels related to SNPs at +191 and +292 may constitute a susceptibility factor for RTI and VOC frequency. PMID:27603703

  10. Influence of $\\phi$ mesons on negative kaons in Ni+Ni collisions at 1.91A GeV beam energy

    CERN Document Server

    Piasecki, K; Averbeck, R; Andronic, A; Barret, V; Basrak, Z; Bastid, N; Benabderrahmane, M L; Berger, M; Buehler, P; Cargnelli, M; Čaplar, R; Crochet, P; Czerwiakowa, O; Deppner, I; Dupieux, P; Dželalija, M; Fabbietti, L; Fodor, Z; Gasik, P; Gašparić, I; Grishkin, Y; Hartmann, O N; Hildenbrand, K D; Hong, B; Kang, T I; Kecskemeti, J; Kim, Y J; Kirejczyk, M; Kiš, M; Koczon, P; Kotte, R; Lebedev, A; Leifels, Y; Fèvre, A Le; Liu, J L; Lopez, X; Manko, V; Marton, J; Matulewicz, T; Münzer, R; Petrovici, M; Rami, F; Reischl, A; Reisdorf, W; Ryu, M S; Schmidt, P; Schüttauf, A; Seres, Z; Sikora, B; Sim, K S; Simion, V; Siwek-Wilczyńska, K; Smolyankin, V; Suzuki, K; Tymiński, Z; Wagner, P; Weber, I; Widmann, E; Wiśniewski, K; Xiao, Z G; Yushmanov, I; Zhang, Y; Zhilin, A; Zinyuk, V; Zmeskal, J

    2014-01-01

    $\\phi$ and K$^-$ mesons from Ni+Ni collisions at the beam energy of 1.91A GeV have been measured by the FOPI spectrometer, with a trigger selecting central and semi-central events amounting to 51% of the total cross section. The phase space distributions, and the total yield of K$^-$, as well as the kinetic energy distribution and the total yield of $\\phi$ mesons are presented. The $\\phi$\\K$^-$ ratio is found to be $0.44 \\pm 0.07(\\text{stat}) ^{+0.18}_{-0.12} (\\text{syst})$, meaning that about 22% of K$^-$ mesons originate from the decays of $\\phi$ mesons, occurring mostly in vacuum. The inverse slopes of direct kaons are up to about 15 MeV larger than the ones extracted within the one-source model, signalling that a considerable share of gap between the slopes of K$^+$ and K$^-$ could be explained by the contribution of $\\phi$ mesons to negative kaons.

  11. Crystal structure of Sc1.91In1.39Mo15Se19, containing Mo6 and Mo9 clusters

    Directory of Open Access Journals (Sweden)

    Patrick Gougeon

    2015-07-01

    Full Text Available The structure of scandium indium pentadecamolybdenum nonadecaselenide, Sc1.91In1.39Mo15Se19, is isotypic with In2.9Mo15Se19 [Grüttner et al. (1979. Acta Cryst. B35, 285–292]. It is characterized by two cluster units Mo6Sei8Sea6 and Mo9Sei11Sea6 (where i represents inner and a apical atoms that are present in a 1:1 ratio. The cluster units are centered at Wyckoff positions 2b and 2c and have point-group symmetry -3 and -6, respectively. The clusters are interconnected through additional Mo—Se bonds. Sc—Se and In—Se bonds complete the structural set-up. In the title compound, the Sc3+ cations replace the trivalent indium atoms present in In2.9Mo15Se19, and a deficiency is observed at the monovalent indium site. One Mo, one Se and the Sc atom are situated on mirror planes, whereas two other Se atoms and the In atom are situated on threefold rotation axes.

  12. SOLVENT HOLD TANK SAMPLE RESULTS FOR MCU-13-189, MCU-13-190, AND MCU-13-191: QUARTERLY SAMPLE FROM SEPTEMBER 2013

    Energy Technology Data Exchange (ETDEWEB)

    Fondeur, F.; Taylor-Pashow, K.

    2013-10-31

    Savannah River National Laboratory (SRNL) analyzed solvent samples from Modular Caustic-Side Solvent Extraction Unit (MCU) in support of continuing operations. A quarterly analysis of the solvent is required to maintain solvent composition within specifications. Analytical results of the analyses of Solvent Hold Tank (SHT) samples MCU-13-189, MCU-13-190, and MCU-13-191 received on September 4, 2013 are reported. The results show that the solvent (remaining heel in the SHT tank) at MCU contains excess Isopar L and a deficit concentration of modifier and trioctylamine when compared to the standard MCU solvent. As with the previous solvent sample results, these analyses indicate that the solvent does not require Isopar L trimming at this time. Since MCU is switching to NGS, there is no need to add TOA nor modifier. SRNL also analyzed the SHT sample for {{sup 137}Cs content and determined the measured value is within tolerance and the value has returned to levels observed in 2011.

  13. High-resolution extreme ultraviolet spectroscopy of G191-B2B: structure of the stellar photosphere and the surrounding interstellar medium

    Science.gov (United States)

    Barstow, M. A.; Cruddace, R. G.; Kowalski, M. P.; Bannister, N. P.; Yentis, D.; Lapington, J. S.; Tandy, J. A.; Hubeny, I.; Schuh, S.; Dreizler, S.; Barbee, T. W.

    2005-10-01

    We have continued our detailed analysis of the high-resolution (R= 4000) spectroscopic observation of the DA white dwarf G191-B2B, obtained by the Joint Astrophysical Plasmadynamic Experiment (J-PEX) normal incidence sounding rocket-borne telescope, comparing the observed data with theoretical predictions for both homogeneous and stratified atmosphere structures. We find that the former models give the best agreement over the narrow waveband covered by J-PEX, in conflict with what is expected from previous studies of the lower resolution but broader wavelength coverage Extreme Ultraviolet Explorer spectra. We discuss the possible limitations of the atomic data and our understanding of the stellar atmospheres that might give rise to this inconsistency. In our earlier study, we obtained an unusually high ionization fraction for the ionized HeII present along the line of sight to the star. In the present paper, we obtain a better fit when we assume, as suggested by Space Telescope Imaging Spectrograph results, that this HeII resides in two separate components. When one of these is assigned to the local interstellar cloud, the implied He ionization fraction is consistent with measurements along other lines of sight. However, the resolving power and signal-to-noise available from the instrument configuration used in this first successful J-PEX flight are not sufficient to clearly identify and prove the existence of the two components.

  14. Effect of Magnetic Treatment on Amount and Generation Time of Slow-Growing Rhizobium(USDA110) and Fast-growing Rhizobium(USDA191)%磁场处理对根瘤菌(USDA110)和(USDA191)数量及世代时间的影响

    Institute of Scientific and Technical Information of China (English)

    程希雷; 依艳丽

    2009-01-01

    The effects of magnetic treatment on amount and growth rate of slow-growing rhizobium(USDA110)and fast-growing rhizobium(USDA191)by incubation experiments were studied. The results showed that magnetic field had the effects on the growth of rhizobium strains, and all the treatments had positive effects, but magnetic field intensity and treatment time had different effects. The effects of magnetic field intensity and exposure time were different. In magnetic field intensity ,300 mT treatments had the most significant effect. In exposure time, 5 min treatment had the most significant effect and the growth rate of rhizobium was accelerated and generation time was shortened under magnetic treatment after the magnetic treatment.%本试验通过室内培养方法,研究了磁场处理后根瘤菌USDA110(慢生型)和USDA191(快生型)的数量和生长速度的变化.结果表明:磁场对根瘤菌菌落的生长有影响,所有处理均起正效应,但磁场强度和磁处理时间对其影响的效果不同.磁场强度表现为 300 mT效果最显著;磁处理时间以5 min效果最显著.经磁场处理后,根瘤菌的生长速度加快,世代时间缩短.

  15. Stellar laboratories II. New Zn IV and Zn V oscillator strengths and their validation in the hot white dwarfs G191-B2B and RE0503-289

    CERN Document Server

    Rauch, T; Quinet, P; Kruk, J W

    2014-01-01

    For the spectral analysis of high-resolution and high-signal-to-noise spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model-atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. In a recent analysis of the ultraviolet (UV) spectrum of the DA-type white dwarf G191-B2B, 21 Zn IV lines were newly identified. Because of the lack of Zn IV data, transition probabilities of the isoelectronic Ge VI were adapted for a first, coarse determination of the photospheric Zn abundance. We performed new calculations of Zn IV and Zn V oscillator strengths to consider their radiative and collisional bound-bound transitions in detail in our NLTE stellar-atmosphere models for the analysis of the Zn IV - V spectrum exhibited in high-resolution and high-S/N UV observations of G191-B2B and RE0503-289. In the UV spectrum of G191-B2B, we identify 31 Zn IV and 16 Zn V lines. Most of these are identified for the first time in an...

  16. Sweet Taste Receptor TAS1R2 Polymorphism (Val191Val) Is Associated with a Higher Carbohydrate Intake and Hypertriglyceridemia among the Population of West Mexico

    Science.gov (United States)

    Ramos-Lopez, Omar; Panduro, Arturo; Martinez-Lopez, Erika; Roman, Sonia

    2016-01-01

    Some high-carbohydrate diets may lead to obesity and multiple metabolic disorders, including hypertriglyceridemia (HTG). This lipid abnormality is considered an important risk factor for cardiovascular disease and type 2 diabetes. The sweet taste receptor TAS1R2 polymorphism (Ile191Val) has been reported to be associated with carbohydrate intake. The aim of this study was to analyze the association of the TAS1R2 gene polymorphism with carbohydrate intake and HTG among the population of West Mexico. In a cross-sectional study, 441 unrelated subjects were analyzed for TAS1R2 genotypes (Ile/Ile, Ile/Val and Val/Val) by an allelic discrimination assay. Biochemical tests and a three-day food record were assessed. The Val/Val genotype carriers had a higher intake of total carbohydrates, fiber and servings of cereals and vegetables than the other genotype carriers. The Val/Val genotype conferred a higher risk for HTG than the Ile/Val and Ile/Ile genotypes (OR = 3.26, 95%CI 1.35–7.86, p = 0.006 and OR = 2.61, 95%CI 1.12–6.07, p = 0.02, respectively). Furthermore, the Val/Val genotype was associated with approximately 30% higher triglycerides compared with Ile/Val and Ile/Ile genotypes (β = 44.09, 95%CI 9.94–78.25, p = 0.01 and β = 45.7, 95%CI 10.85–80.54, p = 0.01, respectively). In conclusion, the Val/Val genotype of TAS1R2 was associated with a higher carbohydrate intake and HTG. PMID:26907331

  17. Gene Flow Across Genus Barriers - Conjugation of Dinoroseobacter shibae's 191-kb Killer Plasmid into Phaeobacter inhibens and AHL-mediated Expression of Type IV Secretion Systems.

    Science.gov (United States)

    Patzelt, Diana; Michael, Victoria; Päuker, Orsola; Ebert, Matthias; Tielen, Petra; Jahn, Dieter; Tomasch, Jürgen; Petersen, Jörn; Wagner-Döbler, Irene

    2016-01-01

    Rhodobacteraceae harbor a conspicuous wealth of extrachromosomal replicons (ECRs) and therefore the exchange of genetic material via horizontal transfer has been supposed to be a major evolutionary driving force. Many plasmids in this group encode type IV secretion systems (T4SS) that are expected to mediate transfer of proteins and/or DNA into host cells, but no experimental evidence of either has yet been provided. Dinoroseobacter shibae, a species of the Roseobacter group within the Rhodobacteraceae family, contains five ECRs that are crucial for anaerobic growth, survival under starvation and the pathogenicity of this model organism. Here we tagged two syntenous but compatible RepABC-type plasmids of 191 and 126-kb size, each encoding a T4SS, with antibiotic resistance genes and demonstrated their conjugational transfer into a distantly related Roseobacter species, namely Phaeobacter inhibens. Pulsed field gel electrophoresis showed transfer of those replicons into the recipient both individually but also together documenting the efficiency of conjugation. We then studied the influence of externally added quorum sensing (QS) signals on the expression of the T4SS located on the sister plasmids. A QS deficient D. shibae null mutant (ΔluxI1 ) lacking synthesis of N-acyl-homoserine lactones (AHLs) was cultivated with a wide spectrum of chemically diverse long-chain AHLs. All AHLs with lengths of the acid side-chain ≥14 reverted the ΔluxI1 phenotype to wild-type. Expression of the T4SS was induced up to log2 ∼3fold above wild-type level. We hypothesize that conjugation in roseobacters is QS-controlled and that the QS system may detect a wide array of long-chain AHLs at the cell surface.

  18. Sweet Taste Receptor TAS1R2 Polymorphism (Val191Val Is Associated with a Higher Carbohydrate Intake and Hypertriglyceridemia among the Population of West Mexico

    Directory of Open Access Journals (Sweden)

    Omar Ramos-Lopez

    2016-02-01

    Full Text Available Some high-carbohydrate diets may lead to obesity and multiple metabolic disorders, including hypertriglyceridemia (HTG. This lipid abnormality is considered an important risk factor for cardiovascular disease and type 2 diabetes. The sweet taste receptor TAS1R2 polymorphism (Ile191Val has been reported to be associated with carbohydrate intake. The aim of this study was to analyze the association of the TAS1R2 gene polymorphism with carbohydrate intake and HTG among the population of West Mexico. In a cross-sectional study, 441 unrelated subjects were analyzed for TAS1R2 genotypes (Ile/Ile, Ile/Val and Val/Val by an allelic discrimination assay. Biochemical tests and a three-day food record were assessed. The Val/Val genotype carriers had a higher intake of total carbohydrates, fiber and servings of cereals and vegetables than the other genotype carriers. The Val/Val genotype conferred a higher risk for HTG than the Ile/Val and Ile/Ile genotypes (OR = 3.26, 95%CI 1.35–7.86, p = 0.006 and OR = 2.61, 95%CI 1.12–6.07, p = 0.02, respectively. Furthermore, the Val/Val genotype was associated with approximately 30% higher triglycerides compared with Ile/Val and Ile/Ile genotypes (β = 44.09, 95%CI 9.94–78.25, p = 0.01 and β = 45.7, 95%CI 10.85–80.54, p = 0.01, respectively. In conclusion, the Val/Val genotype of TAS1R2 was associated with a higher carbohydrate intake and HTG.

  19. Chemonuclear studies for identification for new production routes for the therapeutically useful radionuclides {sup 140}Nd, {sup 192}Ir, {sup 191}Pt, {sup 193m}Pt, und {sup 195m}Pt; Kernchemische Studien zur Entwicklung neuerer Produktionsverfahren fuer die therapierelevanten Radionuklide {sup 140}Nd, {sup 192}Ir, {sup 191}Pt, {sup 193m}Pt, und {sup 195m}Pt

    Energy Technology Data Exchange (ETDEWEB)

    Hilgers, K.

    2005-12-15

    New production routes for the therapeutically useful radionuclides {sup 140}Nd, {sup 192}Ir, {sup 191}Pt, {sup 193m}Pt and {sup 195m}Pt were investigated. Cross section data were measured using the stacked-foil technique and compared with theoretical calculations. A production method for the platinum nuclides was developed. The {sup 141}Pr(p, 2n){sup 140}Nd and {sup nat}Ce({sup 3}He, xn){sup 140}Nd reactions were investigated for production of {sup 140}Nd. Cross section data of nuclear reactions leading to the side products {sup 141}Nd, {sup 139}Nd and {sup 139}Ce could also be achieved. The experimental data were compared with theoretical calculations using the code ALICE-IPPE. A comparison of the calculated thick target yields showed that the {sup 141}Pr(p, 2n){sup 140}Nd reaction gives a higher yield. The {sup 192}Os(p, n){sup 192}Ir reaction was examined in the context of the production of {sup 192}Ir. Cross section data were determined and compared with theoretical calculations using the codes ALICE-IPPE and EMPIRE II. The yield of this reaction was compared with the yield of the reactor production of this nuclide. The reactor production seems to be more suitable because of a higher purity and yield. Cross section data were measured for the {sup 192}Os({alpha}, n){sup 195m}Pt, {sup 192}Os({alpha}, 3n){sup 193m}Pt and {sup 192}Os({sup 3}He, 4n){sup 191}Pt reactions. The activity of {sup 193m}Pt and {sup 195m}Pt was determined by X-ray spectroscopy after a chemical separation procedure. The ALICE-IPPE code was found to be inappropriate to reproduce the experimental values. The calculated yields were compared with the yields of other reactions, especially the reactor production of {sup 195m}Pt. The yield of the {sup 192}Os({alpha}, n){sup 195m}Pt reaction is lower compared to the yield of the reactor production, but offers lower target costs and higher specific activity. A production method for {sup 193m}Pt and {sup 195m}Pt was developed. Batch yields of 0.9 MBq

  20. Efficacy of double-stranded RNA against white spot syndrome virus (WSSV non-structural (orf89, wsv191 and structural (vp28, vp26 genes in the Pacific white shrimp Litopenaeus vannamei

    Directory of Open Access Journals (Sweden)

    César M. Escobedo-Bonilla

    2015-04-01

    Full Text Available White spot syndrome virus (WSSV is a major pathogen in shrimp aquaculture. RNA interference (RNAi is a promising tool against viral infections. Previous works with RNAi showed different antiviral efficacies depending on the silenced gene. This work evaluated the antiviral efficacy of double-stranded (ds RNA against two non-structural (orf89, wsv191 WSSV genes compared to structural (vp26, vp28 genes to inhibit an experimental WSSV infection. Gene orf89 encodes a putative regulatory protein and gene white spot virus (wsv191 encodes a nonspecific nuclease; whereas genes vp26 and vp28 encode envelope proteins, respectively. Molecules of dsRNA against each of the WSSV genes were intramuscularly injected (4 μg per shrimp into a group of shrimp 48 h before a WSSV challenge. The highest antiviral activity occurred with dsRNA against orf89, vp28 and vp26 (cumulative mortalities 10%, 10% and 21%, respectively. In contrast, the least effective treatment was wsv191 dsRNA (cumulative mortality 83%. All dead animals were WSSV-positive by one-step PCR, whereas reverse-transcription PCR of all surviving shrimp confirmed inhibition of virus replication. This study showed that dsRNA against WSSV genes orf89, vp28 and vp26 were highly effective to inhibit virus replication and suggest an essential role in WSSV infection. Non-structural WSSV genes such as orf89 can be used as novel targets to design therapeutic RNAi molecules against WSSV infection.

  1. A Continuous-Wave Ho:YAlO3 Laser with Output 8.5 W Pumped by a 1.91 μm Laser at Room Temperature

    Institute of Scientific and Technical Information of China (English)

    YAO Bao-Quan; YANG Xiao-Tao; DUAN Xiao-Ming; WANG Tian-Heng; JU You-Lun; WANG Yue-Zhu

    2009-01-01

    @@ A cw high efficient Ho:YAlO3 laser pumped by 1.91 μm diode-pumped Tm:YLF laser at room temperature is realized. The maximum output power reaches 8.5 W when the incident pump power is 15.6 W. The slope efficiency is 63.7%, and the Tm:YLF to Ho:YAP optical conversion efficiency is 54.5%. The laser wavelength is 2118.3nm when the transmission of output coupler is 30%. The beam quality factor is M2~1.39 measured by the traveling knife-edge method.

  2. Stellar laboratories. VIII. New Zr IV - VII, Xe IV - V, and Xe VII oscillator strengths and the Al, Zr, and Xe abundances in the hot white dwarfs G191-B2B and RE0503-289

    CERN Document Server

    Rauch, T; Quinet, P; Loebling, L; Hoyer, D; Werner, K; Kruk, J W; Demleitner, M

    2016-01-01

    For the spectral analysis of high-resolution and high-signal-to-noise spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. To search for Zr and Xe lines in the ultraviolet (UV) spectra of G191-B2B and RE0503-289, new Zr IV-VII, Xe IV-V, and Xe VIII oscillator strengths were calculated. This allows for the first time, determination of the Zr abundance in white dwarf (WD) stars and improvement of the Xe abundance determinations. We calculated Zr IV-VII, Xe IV-V, and Xe VIII oscillator strengths to consider radiative and collisional bound-bound transitions of Zr and Xe in our NLTE stellar-atmosphere models for the analysis of their lines exhibited in UV observations of the hot WDs G191-B2B and RE0503-289. We identified one new Zr IV, 14 new Zr V, and ten new Zr VI lines in the spectrum of RE0503-289. Zr was detected for the first time in a WD. We mea...

  3. Stellar laboratories IV. New Ga IV, Ga V, and Ga VI oscillator strengths and the gallium abundance in the hot white dwarfs G191-B2B and RE0503-289

    CERN Document Server

    Rauch, T; Quinet, P; Kruk, J W

    2015-01-01

    For the spectral analysis of high-resolution and high-signal-to-noise (S/N) spectra of hot stars, advanced non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These atmospheres are strongly dependent on the reliability of the atomic data that are used to calculate them. Reliable Ga IV - VI oscillator strengths are used to identify Ga lines in the spectra of the DA-type white dwarf G191-B2B and the DO-type white dwarf RE0503-289 and to determine their photospheric Ga abundances. We newly calculated Ga IV - VI oscillator strengths to consider their radiative and collisional bound-bound transitions in detail in our NLTE stellar-atmosphere models for analyzing of Ga lines exhibited in high-resolution and high-S/N UV observations of G191-B2B and RE0503-289. We unambiguously detected 20 isolated and 6 blended (with lines of other species) Ga V lines in the Far Ultraviolet Spectroscopic Explorer (FUSE) spectrum of RE0503-289. The identification of Ga IV and Ga VI lines is uncertain because th...

  4. Stellar laboratories III. New Ba V, Ba VI, and Ba VII oscillator strengths and the barium abundance in the hot white dwarfs G191-B2B and RE0503-289

    CERN Document Server

    Rauch, T; Quinet, P; Kruk, J W

    2014-01-01

    For the spectral analysis of high-resolution and high-signal-to-noise (S/N) spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. Reliable Ba V - VII oscillator strengths are used to identify Ba lines in the spectra of the DA-type white dwarf G191-B2B and the DO-type white dwarf RE0503-289 and to determine their photospheric Ba abundances. We newly calculated Ba V - VII oscillator strengths to consider their radiative and collisional bound-bound transitions in detail in our NLTE stellar-atmosphere models for the analysis of Ba lines exhibited in high-resolution and high-S/N UV observations of G191-B2B and RE0503-289. For the first time, we identified highly ionized Ba in the spectra of hot white dwarfs. We detected Ba VI and Ba VII lines in the Far Ultraviolet Spectroscopic Explorer (FUSE) spectrum of RE0503-289. The Ba VI / Ba VII ionization equil...

  5. Stellar laboratories. II. New Zn iv and Zn v oscillator strengths and their validation in the hot white dwarfs G191-B2B and RE 0503-289

    Science.gov (United States)

    Rauch, T.; Werner, K.; Quinet, P.; Kruk, J. W.

    2014-04-01

    Context. For the spectral analysis of high-resolution and high-signal-to-noise (S/N) spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. In a recent analysis of the ultraviolet (UV) spectrum of the DA-type white dwarf G191-B2B, 21 Zn iv lines were newly identified. Because of the lack of Zn iv data, transition probabilities of the isoelectronic Ge vi were adapted for a first, coarse determination of the photospheric Zn abundance. Aims: Reliable Zn iv and Zn v oscillator strengths are used to improve the Zn abundance determination and to identify more Zn lines in the spectra of G191-B2B and the DO-type white dwarf RE 0503-289. Methods: We performed new calculations of Zn iv and Zn v oscillator strengths to consider their radiative and collisional bound-bound transitions in detail in our NLTE stellar-atmosphere models for the analysis of the Zn iv - v spectrum exhibited in high-resolution and high-S/N UV observations of G191-B2B and RE 0503-289. Results: In the UV spectrum of G191-B2B, we identify 31 Zn iv and 16 Zn v lines. Most of these are identified for the first time in any star. We can reproduce well almost all of them at log Zn = -5.52 ± 0.2 (mass fraction, about 1.7 times solar). In particular, the Zn iv / Zn v ionization equilibrium, which is a very sensitive Teff indicator, is well reproduced with the previously determined and log g = 7.60 ± 0.05. In the spectrum of RE 0503-289, we identified 128 Zn v lines for the first time and determined log Zn = -3.57 ± 0.2 (155 times solar). Conclusions: Reliable measurements and calculations of atomic data are a pre-requisite for stellar-atmosphere modeling. Observed Zn iv and Zn v line profiles in two white dwarf (G191-B2B and RE 0503-289) ultraviolet spectra were well reproduced with our newly calculated oscillator strengths. This allowed us to

  6. Targeting of the WT191-138 fragment to human dendritic cells improves leukemia-specific T-cell responses providing an alternative approach to WT1-based vaccination.

    Science.gov (United States)

    Dagvadorj, Nergui; Deuretzbacher, Anne; Weisenberger, Daniela; Baumeister, Elke; Trebing, Johannes; Lang, Isabell; Köchel, Carolin; Kapp, Markus; Kapp, Kerstin; Beilhack, Andreas; Hünig, Thomas; Einsele, Hermann; Wajant, Harald; Grigoleit, Götz Ulrich

    2017-03-01

    Due to its immunogenicity and overexpression concomitant with leukemia progression, Wilms tumor protein 1 (WT1) is of particular interest for immunotherapy of AML relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT). So far, WT1-specific T-cell responses have mainly been induced by vaccination with peptides presented by certain HLA alleles. However, this approach is still not widely applicable in clinical practice due to common limitations of HLA restriction. Dendritic cell (DC) vaccines electroporated with mRNA encoding full-length protein have also been tested for generating WT1-derived peptides for presentation to T-cells. Alternatively, an efficient and broad WT1 peptide presentation could be elicited by triggering receptor-mediated protein endocytosis of DCs. Therefore, we developed antibody fusion proteins consisting of an antibody specific for the DEC205 endocytic receptor on human DCs and various fragments of WT1 as DC-targeting recombinant WT1 vaccines (anti-hDEC205-WT1). Of all anti-hDEC205-WT1 fusion proteins designed for overcoming insufficient expression, anti-hDEC205-WT110-35, anti-hDEC205-WT191-138, anti-hDEC205-WT1223-273, and anti-hDEC205-WT1324-371 were identified in good yields. The anti-hDEC205-WT191-138 was capable of directly inducing ex vivo T-cell responses by co-incubation of the fusion protein-loaded monocyte-derived mature DCs and autologous T-cells of either healthy or HSCT individuals. Furthermore, the DC-targeted WT191-138-induced specific T-cells showed a strong cytotoxic activity by lysing WT1-overexpressing THP-1 leukemia cells in vitro while sparing WT1-negative hematopoietic cells. In conclusion, our approach identifies four WT1 peptide-antibody fusion proteins with sufficient production and introduces an alternative vaccine that could be easily translated into clinical practice to improve WT1-directed antileukemia immune responses after allo-HSCT.

  7. All solid-state 191.7 nm deep-UV light source by seventh harmonic generation of an 888 nm pumped, Q-switched 1342 nm Nd:YVO₄ laser with excellent beam quality.

    Science.gov (United States)

    Koch, Peter; Bartschke, Juergen; L'huillier, Johannes A

    2014-06-02

    In this paper we report on the realization of a deep-UV light source using the 1.3 μm transition of neodymium as pumping wavelength. The 191.7 nm radiation was obtained by generating the seventh harmonic of a high-power Q-switched 1342 nm Nd:YVO4 laser. A cesium lithium borate crystal was used for sum frequency mixing of the sixth harmonic and the fundamental. With a total of four conversion stages, up to 240 mW were achieved, with excellent beam quality at 155 mW (M2 < 1.7) and 190 mW (M2 < 1.9).

  8. Analysis of ADR Reports in a Hospital in 2014%某院2014年191例药品不良反应监测报告情况分析

    Institute of Scientific and Technical Information of China (English)

    杨丽萍; 王国俊

    2016-01-01

    目的:分析某院药品不良反应( ADR )的发生和监测报告的特点及规律,为临床安全用药、合理用药提供参考。方法对某院2014年ADR报告191例进行分类、统计和分析。结果191例ADR中,以60岁及以上年龄段发生率最高(59.16%);给药途径以静脉给药最多(60.73%);ADR涉及药品113种,以抗肿瘤药物及抗感染药物为主;ADR累及器官或系统多为胃肠系统损害(47例)及皮肤附件损害(43例);新的或严重的ADR 22例(11.52%)。结论医务人员应重视ADR监测工作,尤应加强新的一般和严重类型ADR的监测,选择适宜给药途径,特别关注特殊人群如60岁以上年龄的患者。应提高甄别能力和处置水平,避免或减少ADR的发生,保障患者用药安全。%Objective To analyze the characteristics and regularity of ADRs in a hospital and to promote the rational drug use in the clinical practice. Methods 191 cases of ADR reports in the hospital in 2014 were collected. The relevant data was classified and sta-tistically analyzed according to age, gender, ADR involved organs, drugs, and route of drug administration. Results Among the 191 cases of ADR, the most ADR cases occurred in the age group of above 60 years old, accounting for 59. 16%;about 60. 73% were induced by intravenous administration;among the 113 varieties of drugs involved in ADRs were anticancer drugs and anti-infective drugs. The main clinical manifestations were digestive system injury ( 47 cases ) and lesion of skin ( 43 cases );new or serious ADR were 22 cases ( 11. 52% ) . Conclusion More importance should be attached to ADR collection and reporting work in clinical practice, and the selec-tion of appropriate route of drug administration should be strengthened and more pharmaceutical care should be given to the key groups of people such as over 60 years old people.

  9. Certification of the contents (mass fractions) of Cd, Pb, Se, Cu, Zn, Fe and Mn in wholemeal flour and lyophilized brown bread reference materials. Wholemeal flour - CRM no. 189; brown bread - CRM no. 191

    Energy Technology Data Exchange (ETDEWEB)

    Wagstaffe, P.J.; Griepink, B.; Muntau, H.; Schramel, P.

    1987-01-01

    The report describes the preparation and certification of a wholemeal flour (CRM 189) and a lyophilised brown breas (CRM 191) for their contents (mass fractions) of elements of toxicological and nutritional importance: Cd, Pb, Se, Cu, Zn, Fe and Mn. Indicative values are also given for As, Ca, Cl, Cr, Hg, Mg, Na, Ni, P and K. Details are given of a preliminary intercomparison of methods for these elements in a wholemeal flour sample, homogeneity and stability studies on the two reference materials and the results and evaluation of the certification exercise which involved 21 European Laboratories. Summaries of the certification methods are also presented. The report concludes with a discussion of the most common sources of error in determining the elements of interest and the steps to be taken to control them. With 7 figs., 28 tabs.

  10. Stellar laboratories. IV. New Ga iv, Ga v, and Ga vi oscillator strengths and the gallium abundance in the hot white dwarfs G191-B2B and RE 0503-289

    Science.gov (United States)

    Rauch, T.; Werner, K.; Quinet, P.; Kruk, J. W.

    2015-05-01

    Context. For the spectral analysis of high-resolution and high-signal-to-noise (S/N) spectra of hot stars, advanced non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These atmospheres are strongly dependent on the reliability of the atomic data that are used to calculate them. Aims: Reliable Ga iv-vi oscillator strengths are used to identify Ga lines in the spectra of the DA-type white dwarf G191-B2B and the DO-type white dwarf RE 0503-289 and to determine their photospheric Ga abundances. Methods: We newly calculated Ga iv-vi oscillator strengths to consider their radiative and collisional bound-bound transitions in detail in our NLTE stellar-atmosphere models for analyzing of Ga lines exhibited in high-resolution and high-S/N UV observations of G191-B2B and RE 0503-289. Results: We unambiguously detected 20 isolated and 6 blended (with lines of other species) Ga v lines in the Far Ultraviolet Spectroscopic Explorer (FUSE) spectrum of RE 0503-289. The identification of Ga iv and Ga vi lines is uncertain because they are weak and partly blended by other lines. The determined Ga abundance is 3.5 ± 0.5 × 10-5 (mass fraction, about 625 times the solar value). The Ga iv/Ga v ionization equilibrium, which is a very sensitive indicator for the effective temperature, is well reproduced in RE 0503-289. We identified the strongest Ga iv lines (at 1258.801, 1338.129 Å) in the HST/STIS spectrum of G191-B2B and measured a Ga abundance of 2.0 ± 0.5 × 10-6 (about 22 times solar). Conclusions: Reliable measurements and calculations of atomic data are a prerequisite for stellar-atmosphere modeling. The observed Ga iv-v line profiles in two white dwarf (G191-B2B and RE 0503-289) ultraviolet spectra were well reproduced with our newly calculated oscillator strengths. For the first time, this allowed us to determine the photospheric Ga abundance in white dwarfs. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space

  11. Stellar laboratories. III. New Ba v, Ba vi, and Ba vii oscillator strengths and the barium abundance in the hot white dwarfs G191-B2B and RE 0503-289

    Science.gov (United States)

    Rauch, T.; Werner, K.; Quinet, P.; Kruk, J. W.

    2014-06-01

    Context. For the spectral analysis of high-resolution and high-signal-to-noise (S/N) spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. Aims: Reliable Ba v-vii oscillator strengths are used to identify Ba lines in the spectra of the DA-type white dwarf G191-B2B and the DO-type white dwarf RE 0503-289 and to determine their photospheric Ba abundances. Methods: We newly calculated Ba v-vii oscillator strengths to consider their radiative and collisional bound-bound transitions in detail in our NLTE stellar-atmosphere models for the analysis of Ba lines exhibited in high-resolution and high-S/N UV observations of G191-B2B and RE 0503-289. Results: For the first time, we identified highly ionized Ba in the spectra of hot white dwarfs. We detected Ba vi and Ba vii lines in the Far Ultraviolet Spectroscopic Explorer (FUSE) spectrum of RE 0503-289. The Ba vi/Ba vii ionization equilibrium is well reproduced with the previously determined effective temperature of 70 000 K and surface gravity of log g = 7.5. The Ba abundance is 3.5 ± 0.5 × 10-4 (mass fraction, about 23 000 times the solar value). In the FUSE spectrum of G191-B2B, we identified the strongest Ba vii line (at 993.41 Å) only, and determined a Ba abundance of 4.0 ± 0.5 × 10-6 (about 265 times solar). Conclusions: Reliable measurements and calculations of atomic data are a pre-requisite for stellar-atmosphere modeling. Observed Ba vi-vii line profiles in two white dwarfs' (G191-B2B and RE 0503-289) far-ultraviolet spectra were well reproduced with our newly calculated oscillator strengths. This allowed to determine the photospheric Ba abundance of these two stars precisely. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for

  12. Stellar laboratories . VIII. New Zr iv-vii, Xe iv-v, and Xe vii oscillator strengths and the Al, Zr, and Xe abundances in the hot white dwarfs G191-B2B and RE 0503-289

    Science.gov (United States)

    Rauch, T.; Gamrath, S.; Quinet, P.; Löbling, L.; Hoyer, D.; Werner, K.; Kruk, J. W.; Demleitner, M.

    2017-03-01

    Context. For the spectral analysis of high-resolution and high-signal-to-noise spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. Aims: To search for zirconium and xenon lines in the ultraviolet (UV) spectra of G191-B2B and RE 0503-289, new Zr iv-vii, Xe iv-v, and Xe vii oscillator strengths were calculated. This allows, for the first time, determination of the Zr abundance in white dwarf (WD) stars and improvement of the Xe abundance determinations. Methods: We calculated Zr iv-vii, Xe iv-v, and Xe vii oscillator strengths to consider radiative and collisional bound-bound transitions of Zr and Xe in our NLTE stellar-atmosphere models for the analysis of their lines exhibited in UV observations of the hot WDs G191-B2B and RE 0503-289. Results: We identified one new Zr iv, 14 new Zr v, and ten new Zr vi lines in the spectrum of RE 0503-289. Zr was detected for the first time in a WD. We measured a Zr abundance of -3.5 ± 0.2 (logarithmic mass fraction, approx. 11 500 times solar). We identified five new Xe vi lines and determined a Xe abundance of -3.9 ± 0.2 (approx. 7500 times solar). We determined a preliminary photospheric Al abundance of -4.3 ± 0.2 (solar) in RE 0503-289. In the spectra of G191-B2B, no Zr line was identified. The strongest Zr iv line (1598.948 Å) in our model gave an upper limit of -5.6 ± 0.3 (approx. 100 times solar). No Xe line was identified in the UV spectrum of G191-B2B and we confirmed the previously determined upper limit of -6.8 ± 0.3 (ten times solar). Conclusions: Precise measurements and calculations of atomic data are a prerequisite for advanced NLTE stellar-atmosphere modeling. Observed Zr iv-vi and Xe vi-vii line profiles in the UV spectrum of RE 0503-289 were simultaneously well reproduced with our newly calculated oscillator strengths. Based on observations

  13. CO2冷冻治疗妇女宫颈疾病191例临床分析%Evaluation of CO2 cryotherapy in the treatment of cervical diseases

    Institute of Scientific and Technical Information of China (English)

    孙霭萍; 张小燕; 卞美璐

    2006-01-01

    目的:观察CO2冷冻治疗对于宫颈病变治疗效果.方法:应用Erbokryo CA多功能冷冻治疗仪,以CO2为冷冻剂,治疗宫颈病变191例,定期随访,记录术中、术后临床表现和疗效.结果:宫颈糜烂104例,痊愈90例,显效12例,有效率98.08%.宫颈柱状上皮先天性异位40例,痊愈15例,显效23例,有效率95.5%.纳囊15例,痊愈15例.宫颈内膜炎9例、宫颈尖锐湿疣8例、CIN1伴HPV感染15例,均全部痊愈.191例病例痊愈15例,显效36例,总有效率97.91%.愈合天数平均50d.疾病类型,病变程度,冷冻时间和冷冻次数是影响疗效和愈合天数的相关因素.结论:高压CO2冷冻治疗宫颈疾病、安全、有效、操作简便.

  14. The Virtual Observatory Service TheoSSA: Establishing a Database of Synthetic Stellar Flux Standards I. NLTE Spectral Analysis of the DA-Type White Dwarf G191-B2B *,**,***,****

    Science.gov (United States)

    Rauch, T.; Werner, K.; Bohlin, R.; Kruk, J. W.

    2013-01-01

    Hydrogen-rich, DA-type white dwarfs are particularly suited as primary standard stars for flux calibration. State-of-the-art NLTE models consider opacities of species up to trans-iron elements and provide reliable synthetic stellar-atmosphere spectra to compare with observations. Aims. We will establish a database of theoretical spectra of stellar flux standards that are easily accessible via a web interface. Methods. In the framework of the Virtual Observatory, the German Astrophysical Virtual Observatory developed the registered service TheoSSA. It provides easy access to stellar spectral energy distributions (SEDs) and is intended to ingest SEDs calculated by any model-atmosphere code. In case of the DA white dwarf G191-B2B, we demonstrate that the model reproduces not only its overall continuum shape but also the numerous metal lines exhibited in its ultraviolet spectrum. Results. TheoSSA is in operation and contains presently a variety of SEDs for DA-type white dwarfs. It will be extended in the near future and can host SEDs of all primary and secondary flux standards. The spectral analysis of G191-B2B has shown that our hydrostatic models reproduce the observations best at Teff =60 000 +/- 2000K and log g=7.60 +/- 0.05.We newly identified Fe vi, Ni vi, and Zn iv lines. For the first time, we determined the photospheric zinc abundance with a logarithmic mass fraction of -4.89 (7.5 × solar). The abundances of He (upper limit), C, N, O, Al, Si, O, P, S, Fe, Ni, Ge, and Sn were precisely determined. Upper abundance limits of about 10% solar were derived for Ti, Cr, Mn, and Co. Conclusions. The TheoSSA database of theoretical SEDs of stellar flux standards guarantees that the flux calibration of all astronomical data and cross-calibration between different instruments can be based on the same models and SEDs calculated with different model-atmosphere codes and are easy to compare.

  15. The virtual observatory service TheoSSA: Establishing a database of synthetic stellar flux standards. I. NLTE spectral analysis of the DA-type white dwarf G 191-B2B

    CERN Document Server

    Rauch, T; Kruk, J W; Werner, K

    2013-01-01

    H-rich, DA-type white dwarfs are particularly suited as primary standard stars for flux calibration. State-of-the-art NLTE models consider opacities of species up to trans-iron elements and provide reliable synthetic stellar-atmosphere spectra to compare with observation. We establish a database of theoretical spectra of stellar flux standards that are easily accessible via a web interface. In the framework of the Virtual Observatory, the German Astrophysical Virtual Observatory developed the registered service TheoSSA. It provides easy access to stellar spectral energy distributions (SEDs) and is intended to ingest SEDs calculated by any model-atmosphere code. In case of the DA white dwarf G 191-B2B, we demonstrate that the model reproduces not only its overall continuum shape but also the numerous metal lines exhibited in its ultraviolet spectrum. TheoSSA is in operation and contains presently a variety of SEDs for DA white dwarfs. It will be extended in the near future and can host SEDs of all primary and ...

  16. Population genetics study of 9 CODIS STR loci in Han population in Baishan City.%191名白山市汉族CODIS系统9个STR位点群体遗传学调查

    Institute of Scientific and Technical Information of China (English)

    刘开会; 常彩琴; 王传海; 万荣

    2001-01-01

    目的白山汉族CODIS系统9个STR位点基因频率调查及其法医学应用; 方法实验样本从191 位无相关白山市汉族个体获取,采用PCR复合扩增及310遗传分析仪自动基因分型; 结果这9个STR位点均为高识别率位点,同重庆汉族人群群体遗传学数据比较显示有显著性差异; 结论基因频率适合于白山汉族人群同一性概率及亲子鉴定概率计算;中国南北方汉族在个体识别及亲子鉴定概率计算时应采用本民族自己的等位基因频率.

  17. Odd and Even Partial Waves of $\\eta\\pi^-$ and $\\eta'\\pi^-$ in $\\pi^-p\\to\\eta^{(\\prime)}\\pi^-p$ at $191\\,\\textrm{GeV}/c$

    CERN Document Server

    Adolph, C.; Alexeev, M.G.; Alexeev, G.D.; Amoroso, A.; Andrieux, V.; Anosov, V.; Austregesilo, A.; Badelek, B.; Balestra, F.; Barth, J.; Baum, G.; Beck, R.; Bedfer, Y.; Berlin, A.; Bernhard, J.; Bicker, K.; Bielert, E.R.; Bieling, J.; Birsa, R.; Bisplinghoff, J.; Bodlak, M.; Boer, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bressan, A.; Buchele, M.; Burtin, E.; Capozza, L.; Chiosso, M.; Chung, S.U.; Cicuttin, A.; Crespo, M.L.; Curiel, Q.; Dalla Torre, S.; Dasgupta, S.S.; Dasgupta, S.; Denisov, O.Yu.; Donskov, S.V.; Doshita, N.; Duic, V.; Dunnweber, W.; Dziewiecki, M.; Efremov, A.; Elia, C.; Eversheim, P.D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Finger, M.; M. Finger jr; Fischer, H.; Franco, C.; von Hohenesche, N. du Fresne; Friedrich, J.M.; Frolov, V.; Gautheron, F.; Gavrichtchouk, O.P.; Gerassimov, S.; Geyer, R.; Gnesi, I.; Gobbo, B.; Goertz, S.; Gorzellik, M.; Grabmuller, S.; Grasso, A.; Grube, B.; Grussenmeyer, T.; Guskov, A.; Haas, F.; von Harrach, D.; Hahne, D.; Hashimoto, R.; Heinsius, F.H.; Herrmann, F.; Hinterberger, F.; Hoppner, Ch.; Horikawa, N.; d'Hose, N.; Huber, S.; Ishimoto, S.; Ivanov, A.; Ivanshin, Yu.; Iwata, T.; Jahn, R.; Jary, V.; Jasinski, P.; Jorg, P.; Joosten, R.; Kabuss, E.; Ketzer, B.; Khaustov, G.V.; Khokhlov, Yu. A.; Kisselev, Yu.; Klein, F.; Klimaszewski, K.; Koivuniemi, J.H.; Kolosov, V.N.; Kondo, K.; Konigsmann, K.; Konorov, I.; Konstantinov, V.F.; Kotzinian, A.M.; Kouznetsov, O.; Kramer, M.; Kroumchtein, Z.V.; Kuchinski, N.; Kunne, F.; Kurek, K.; Kurjata, R.P.; Lednev, A.A.; Lehmann, A.; Levillain, M.; Levorato, S.; Lichtenstadt, J.; Maggiora, A.; Magnon, A.; Makke, N.; Mallot, G.K.; Marchand, C.; Martin, A.; Marzec, J.; Matousek, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G.; Meyer, W.; Michigami, T.; Mikhailov, Yu. V.; Miyachi, Y.; Nagaytsev, A.; Nagel, T.; Nerling, F.; Neubert, S.; Neyret, D.; Novy, J.; Nowak, W.D.; Nunes, A.S.; Olshevsky, A.G.; Orlov, I.; Ostrick, M.; Panknin, R.; Panzieri, D.; Parsamyan, B.; Paul, S.; Peshekhonov, D.V.; Platchkov, S.; Pochodzalla, J.; Polyakov, V.A.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Regali, C.; Reicherz, G.; Rocco, E.; Rossiyskaya, N.S.; Ryabchikov, D.I.; Rychter, A.; Samoylenko, V.D.; Sandacz, A.; Sarkar, S.; Savin, I.A.; Sbrizzai, G.; Schiavon, P.; Schill, C.; Schluter, T.; Schmidt, K.; Schmieden, H.; Schonning, K.; Schopferer, S.; Schott, M.; Shevchenko, O.Yu.; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Sosio, S.; Sozzi, F.; Srnka, A.; Steiger, L.; Stolarski, M.; Sulc, M.; Sulej, R.; Suzuki, H.; Szabelski, A.; Szameitat, T.; Sznajder, P.; Takekawa, S.; Wolbeek, J. ter; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Uhl, S.; Uman, I.; Virius, M.; Wang, L.; Weisrock, T.; Wilfert, M.; Windmolders, R.; Wollny, H.; Zaremba, K.; Zavertyaev, M.; Zemlyanichkina, E.; Ziembicki, M.; Zink, A.

    2015-01-01

    Exclusive production of $\\eta\\pi^-$ and $\\eta'\\pi^-$ has been studied with a $191\\,\\textrm{GeV}/c$ $\\pi^-$ beam impinging on a hydrogen target at COMPASS (CERN). Partial-wave analyses reveal different odd/even angular momentum ($L$) characteristics in the inspected invariant mass range up to $3\\,\\textrm{GeV}/c^2$. A striking similarity between the two systems is observed for the $L=2,4,6$ intensities (scaled by kinematical factors) and the relative phases. The known resonances $a_2(1320)$ and $a_4(2040)$ are in line with this similarity. In contrast, a strong enhancement of $\\eta'\\pi^-$ over $\\eta\\pi^-$ is found for the $L=1,3,5$ waves, which carry non-$q\\bar q$ quantum numbers. The $L=1$ intensity peaks at $1.7\\,\\textrm{GeV}/c^2$ in $\\eta'\\pi^-$ and at $1.4\\,\\textrm{GeV}/c^2$ in $\\eta\\pi^-$, the corresponding phase motions with respect to $L=2$ are different.

  18. Comment on ''Transport Properties of Tl{sub 5}Te{sub 3} Single Crystals'' [phys. stat. sol. (a) Vol. 191, No. 1, 322-329 (2002)

    Energy Technology Data Exchange (ETDEWEB)

    Cankurtaran, M.; Celik, H. [Hacettepe University, Faculty of Engineering, Department of Physics, Beytepe, 06800 Ankara (Turkey)

    2007-03-15

    Recently, Gamal et al. [phys. stat. sol. (a) 191, 322 (2002)] reported the results of electrical conductivity, Hall effect and thermoelectric power (TEP) measurements on Tl{sub 5}Te{sub 3} single crystals. The samples used in the study were p-type semiconductors. From the experimental data for the temperature dependence of TEP, Gamal et al. determined the values of 1.6 x 10{sup -41} kg and 1.5 x 10{sup -40} kg, respectively, for the effective masses of electrons and holes in p-type Tl{sub 5}Te{sub 3}, which are about ten orders of magnitude smaller than the free electron mass, 9.11 x 10{sup -31} kg. We argue that the anomalously small values obtained for the effective mass of charge carriers in Tl{sub 5}Te{sub 3} have no physical significance. (copyright 2007 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  19. Odd and even partial waves of ηπ− and η′π− in π−p→η(′π−p at 191 GeV/c

    Directory of Open Access Journals (Sweden)

    C. Adolph

    2015-01-01

    Full Text Available Exclusive production of ηπ− and η′π− has been studied with a 191 GeV/c π− beam impinging on a hydrogen target at COMPASS (CERN. Partial-wave analyses reveal different odd/even angular momentum (L characteristics in the inspected invariant mass range up to 3 GeV/c2. A striking similarity between the two systems is observed for the L=2,4,6 intensities (scaled by kinematical factors and the relative phases. The known resonances a2(1320 and a4(2040 are in line with this similarity. In contrast, a strong enhancement of η′π− over ηπ− is found for the L=1,3,5 waves, which carry non-qq¯ quantum numbers. The L=1 intensity peaks at 1.7 GeV/c2 in η′π− and at 1.4 GeV/c2 in ηπ−, the corresponding phase motions with respect to L=2 are different.

  20. From Collaborative Zone to Collaborative Network:Structure, Pathway and Evolution——The Analysis 191 Intergovernment Agreements in "9 +2" Zone%从合作区到区域合作网络:结构、路径与演进——来自“9+2”合作区191项府际协议的网络分析

    Institute of Scientific and Technical Information of China (English)

    马捷; 锁利铭; 陈斌

    2014-01-01

    本文利用2004-2013年“9+2”合作区191项地方政府府际协议数据,考察合作区内地方政府的理性选择行为对网络治理结构演进的作用机理.研究结果表明:行政地理边界构成的合作区逐步推进了由地方政府个体决策缔结而成的自组织网络,在不同领域通过“地理路径”、“抱团路径”与“借势路径”形成SG、NLO与NAO结构.我国经济社会发展的多目标实现要依据不同合作领域的性质实现跨地理空间区域的网络合作关系,从而实现更大范围内功能区的整合.

  1. Stellar laboratories. VI. New Mo iv-vii oscillator strengths and the molybdenum abundance in the hot white dwarfs G191-B2B and RE 0503-289

    Science.gov (United States)

    Rauch, T.; Quinet, P.; Hoyer, D.; Werner, K.; Demleitner, M.; Kruk, J. W.

    2016-03-01

    Context. For the spectral analysis of high-resolution and high signal-to-noise (S/N) spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. Aims: To identify molybdenum lines in the ultraviolet (UV) spectra of the DA-type white dwarf G191-B2B and the DO-type white dwarf RE 0503-289 and, to determine their photospheric Mo abundances, reliable Mo iv-vii oscillator strengths are used. Methods: We newly calculated Mo iv-vii oscillator strengths to consider their radiative and collisional bound-bound transitions in detail in our NLTE stellar-atmosphere models for the analysis of Mo lines exhibited in high-resolution and high S/N UV observations of RE 0503-289. Results: We identified 12 Mo v and 9 Mo vi lines in the UV spectrum of RE 0503-289 and measured a photospheric Mo abundance of 1.2-3.0 × 10-4 (mass fraction, 22 500-56 400 times the solar abundance). In addition, from the As v and Sn iv resonance lines, we measured mass fractions of arsenic (0.5-1.3 × 10-5, about 300-1200 times solar) and tin (1.3-3.2 × 10-4, about 14 300-35 200 times solar). For G191-B2B, upper limits were determined for the abundances of Mo (5.3 × 10-7, 100 times solar) and, in addition, for Kr (1.1 × 10-6, 10 times solar) and Xe (1.7 × 10-7, 10 times solar). The arsenic abundance was determined (2.3-5.9 × 10-7, about 21-53 times solar). A new, registered German Astrophysical Virtual Observatory (GAVO) service, TOSS, has been constructed to provide weighted oscillator strengths and transition probabilities. Conclusions: Reliable measurements and calculations of atomic data are a prerequisite for stellar-atmosphere modeling. Observed Mo v-vi line profiles in the UV spectrum of the white dwarf RE 0503-289 were well reproduced with our newly calculated oscillator strengths. For the first time, this allowed the photospheric Mo

  2. The virtual observatory service TheoSSA: Establishing a database of synthetic stellar flux standards. I. NLTE spectral analysis of the DA-type white dwarf G191-B2B

    Science.gov (United States)

    Rauch, T.; Werner, K.; Bohlin, R.; Kruk, J. W.

    2013-12-01

    Context. Hydrogen-rich, DA-type white dwarfs are particularly suited as primary standard stars for flux calibration. State-of-the-art NLTE models consider opacities of species up to trans-iron elements and provide reliable synthetic stellar-atmosphere spectra to compare with observations. Aims: We will establish a database of theoretical spectra of stellar flux standards that are easily accessible via a web interface. Methods: In the framework of the Virtual Observatory, the German Astrophysical Virtual Observatory developed the registered service TheoSSA. It provides easy access to stellar spectral energy distributions (SEDs) and is intended to ingest SEDs calculated by any model-atmosphere code. In case of the DA white dwarf G191-B2B, we demonstrate that the model reproduces not only its overall continuum shape but also the numerous metal lines exhibited in its ultraviolet spectrum. Results: TheoSSA is in operation and contains presently a variety of SEDs for DA-type white dwarfs. It will be extended in the near future and can host SEDs of all primary and secondary flux standards. The spectral analysis of G191-B2B has shown that our hydrostatic models reproduce the observations best at and log g = 7.60 ± 0.05. We newly identified Fe vi, Ni vi, and Zn iv lines. For the first time, we determined the photospheric zinc abundance with a logarithmic mass fraction of -4.89 (7.5 × solar). The abundances of He (upper limit), C, N, O, Al, Si, O, P, S, Fe, Ni, Ge, and Sn were precisely determined. Upper abundance limits of about 10% solar were derived for Ti, Cr, Mn, and Co. Conclusions: The TheoSSA database of theoretical SEDs of stellar flux standards guarantees that the flux calibration of all astronomical data and cross-calibration between different instruments can be based on the same models and SEDs calculated with different model-atmosphere codes and are easy to compare. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope

  3. Gene flow across genus barriers – Conjugation of Dinoroseobacter shibae´s 191-kb killer plasmid into Phaeobacter inhibens and AHL-mediated expression of type IV secretion systems

    Directory of Open Access Journals (Sweden)

    Diana ePatzelt

    2016-05-01

    Full Text Available Rhodobacteraceae harbor a conspicuous wealth of extrachromosomal replicons (ECRs and therefore the exchange of genetic material via horizontal transfer has been supposed to be a major evolutionary driving force. Many plasmids in the roseobacter group encode type IV secretion systems (T4SS that generally mediate transfer of proteins and/or DNA into host cells, but no experimental evidence of either has yet been provided. Dinoroseobacter shibae contains five ECRs that are crucial for anaerobic growth, survival under starvation and the pathogenicity of this model organism. Here we tagged two syntenous but compatible RepABC-type plasmids of 191 kb and 126-kb size, each harboring a T4SS, with antibiotic resistance genes and demonstrated their conjugational transfer into a distantly related roseo-bacter species, namely Phaeobacter inhibens. Pulsed field gel electrophoresis showed transfer of those replicons into the recipient both individually but also together documenting the efficiency of conjugation. We then studied the influence of externally added quorum sensing (QS signals on the expression of the T4SS located on the sister plasmids. A QS deficient D. shibae null mutant (ΔluxI1 lacking synthesis of N-acyl-homoserine lactones (AHLs was cultivated with a wide spectrum of chemically diverse long-chain AHLs. All AHLs with lengths of the acid side-chain >14 reverted the ΔluxI1 phenotype to wild-type. Expression of the T4SS was induced above wild-type level. We hypothesize that conjugation in roseobacters is QS-controlled and that the QS system may detect a wide array of long-chain AHLs at the cell surface.

  4. 40 CFR 60.191 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... means a building unit which houses a group of electrolytic cells in which aluminum is produced. Potroom... facility manufacturing aluminum by electrolytic reduction. Primary control system means an air pollution... at the cell. Roof monitor means that portion of the roof of a potroom where gases not captured at...

  5. 32 CFR 191.3 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... individual who is an alcoholic or drug abuser and whose current use of alcohol or drugs prevents such... alcohol or drug abuse, would constitute a direct threat to property or to the safety of others. As used...

  6. 40 CFR 63.191 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... source, owner or operator, performance evaluation, performance test, permit program, permitting authority... part. Bench-scale batch process means a batch process (other than a research and development facility...: photochlorination reactors, thermal chlorination reactors, and condensers. Ethylidene Norbornene means the...

  7. 40 CFR 191.12 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... that might affect the disposal system; (2) examines the effects of these processes and events on the... rem or one joule per kilogram. The abbreviation is “Sv.” Undisturbed performance means the...

  8. 19 CFR 10.191 - General.

    Science.gov (United States)

    2010-04-01

    ... directly from a beneficiary country as provided in § 10.193 and which meets the country of origin criteria..., prepared or preserved in any manner, in airtight containers. (iv) Petroleum, or any product derived from petroleum, provided for in headings 2709 and 2710, Harmonized Tariff Schedule of the United States...

  9. 19 CFR 191.92 - Accelerated payment.

    Science.gov (United States)

    2010-04-01

    ... contain: (i) Company name and address; (ii) Internal Revenue Service (IRS) number (with suffix); (iii... involved, with differing inventory, manufacturing, and shipping methods, greater detail in the description... method (for example, paper, electronic, etc.); (iv) A list of the records that will be...

  10. 19 CFR 191.32 - Substitution drawback.

    Science.gov (United States)

    2010-04-01

    ... provisions of the manufacturing drawback law, on the commercially interchangeable substituted merchandise is..., and liabilities of the predecessor; or (ii) The assets and other business interests of a division... drawback rights, whether vested or contingent. (3) Certifications and required evidence—(i) Records...

  11. 49 CFR 191.3 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS... Administrator, Pipeline and Hazardous Materials Safety Administration or his or her delegate Gas means natural...) An event that involves a release of gas from a pipeline or of liquefied natural gas or gas......

  12. 32 CFR 191.1 - Purpose.

    Science.gov (United States)

    2010-07-01

    ... Opportunity (EEO) Program, to include affirmative action programs, consistent with guidance from the Equal...), the Asian/Pacific Islander Employment Program (AEP), the American Indian/Alaskan Native...

  13. 32 CFR 191.9 - Information requirements.

    Science.gov (United States)

    2010-07-01

    ... accomplishment reports, civil rights budget reports, semiannual discrimination complaint reports, and Federal... accomplishment reports for minorities, women, and people with disabilities to the ASD(FM&P), or designee,...

  14. 32 CFR 191.6 - Procedures.

    Science.gov (United States)

    2010-07-01

    .... (7) Develop procedures for and implement a program to eliminate sexual harassment in Component work places, consistent with DoD Policy on Sexual Harassment memorandums, and to ensure compliance with...

  15. BDML Metadata: 191 [SSBD[Archive

    Lifescience Database Archive (English)

    Full Text Available NC-SA 0.180 d800e60b-630a-4560-a005-80e673a1d25d 0.105 x 0.105 x 0.5 (micrometer), 40 (second) http://ssbd.qbic.riken.jp/data.../source/Ce_KK_P002/RNAi_T07C4.7_040831_02.zip http://ssbd.qbic.riken.jp/data.../bdml/Ce_KK_P002/RNAi_T07C4.7_040831_02.bdml0.18.xml http://ssbd.qbic.riken.jp/data/pdpml/Ce_KK_...P002.pdpml0.06.xml http://ssbd.qbic.riken.jp/search/d800e60b-630a-4560-a005-80e673a1d25d/ http://ssbd.qbic.riken.jp/omero/webclient/?show=dataset-96 ...

  16. 49 CFR 572.191 - General description.

    Science.gov (United States)

    2010-10-01

    ... technical drawings and specifications described in Drawing 180-0000, the titles of which are listed in Table..., small adult female, is defined by: (1) The drawings and specifications contained in the “Drawings and...-6000-1 Arm Assembly Right Molded 180-6000-2 (2) The “Parts/Drawing List, Part 572 Subpart V,...

  17. Reference: 191 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available T2 and 3 synthesized in recombinant bacteria and yeast possessed in vitro enzyme activity higher...acteria or yeast, the microbial extract did not contain LPAT activity higher than the endogenous LPAT activi

  18. 19 CFR 191.2 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... under the provision for the substitution of finished petroleum derivatives, § 313(p), as amended (19 U.S... manufactured or produced concurrently in the same operation. Relative value is based on the market value, or... the manufacturing or production process. Market value is generally measured by the selling price,...

  19. A study on the extent of exchange coupling between (Ba0.5Sr0.5Fe12O19)1-x(CoFe2O4)x magnetic nanocomposites synthesized by solgel combustion method

    Science.gov (United States)

    Harikrishnan, V.; Ezhil Vizhi, R.

    2016-11-01

    One step citrate gel combustion method followed by high temperature annealing was employed for preparing (Ba0.5Sr0.5Fe12O19)1-x(CoFe2O4)x (x=0.1, 0.2, and 0.3) composite ferrite powders. The powders were subjected to annealing at 800 °C in order to decisively study the phase evolution of the combined hard and soft ferrites. Thermogravitry (TGA)/differential scanning calorimetry (DSC) analysis exhibited three stages of decomposition in the precursor gels combined with an exothermic peak at 210 °C. X-ray diffraction (XRD) analysis confirmed that the diffraction peaks were perfectly indexed to the hexagonal magnetoplumbite structure of Ba0.5Sr0.5Fe12O19 and the cubic spinel structure of CoFe2O4. Fourier transform infrared spectroscopy (FT-IR) analysis for the samples showed a Co-O stretching vibration accompanied with Co-O-Co or Fe-O-Fe bands at 1220 cm-1. The morphology of the samples were examined by field emission scanning electron microscope (FE-SEM) and transmission electron microscope (TEM). The crystallinity of a selected sample was evaluated by using the high resolution transmission electron microscope (HR-TEM) and selected area electron diffraction (SAED) pattern. It confirmed the presence of planes comprising the hard and soft phases in the synthesized nanocomposites. The magnetic parameters like saturation magnetization MS, remanent magnetization MR, squareness ratio SR, coercivity HC and magnetic moment μB were evaluated using hysteresis by employing vibrating sample magnetometer (VSM). Maximum HC of 4.7 kOe and MS of 60.4 emu/g were obtained for (Ba0.5Sr0.5Fe12O19)0.9(CoFe2O4)0.1. Switching field distribution curves were analysed by using the demagnetization curve. The exchange coupling between the hard and soft phases were analysed by the dM/dH plots and it indicated the exchange coupling first increased with the increase in the concentration of spinels and then decreased. The possible comparison of exchange coupling between the hard and soft phases

  20. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  1. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  2. LaNi5-Assisted Hydrogenation of MgNi2 in the Hybrid Structures of La1.09Mg1.91Ni9D9.5 and La0.91Mg2.09Ni9D9.4

    Directory of Open Access Journals (Sweden)

    Roman V. Denys

    2015-04-01

    Full Text Available This work focused on the high pressure PCT and in situ neutron powder diffraction studies of the LaMg2Ni9-H2 (D2 system at pressures up to 1,000 bar. LaMg2Ni9 alloy was prepared by a powder metallurgy route from the LaNi9 alloy precursor and Mg powder. Two La3−xMgxNi9 samples with slightly different La/Mg ratios were studied, La1.1Mg1.9Ni9 (sample 1 and La0.9Mg2.1Ni9 (sample 2. In situ neutron powder diffraction studies of the La1.09Mg1.91Ni9D9.5 (1 and La0.91Mg2.09Ni9D9.4 (2 deuterides were performed at 25 bar D2 (1 and 918 bar D2 (2. The hydrogenation properties of the (1 and (2 are dramatically different from those for LaNi3. The Mg-containing intermetallics reversibly form hydrides with DHdes = 24.0 kJ/molH2 and an equilibrium pressure of H2 desorption of 18 bar at 20 °C (La1.09Mg1.91Ni9. A pronounced hysteresis of H2 absorption and desorption, ~100 bar, is observed. The studies showed that LaNi5-assisted hydrogenation of MgNi2 in the LaMg2Ni9 hybrid structure takes place. In the La1.09Mg1.91Ni9D9.5 (1 and La0.91Mg2.09Ni9D9.4 (2 (a = 5.263/5.212; c = 25.803/25.71 Å D atoms are accommodated in both Laves and CaCu5-type slabs. In the LaNi5 CaCu5-type layer, D atoms fill three types of interstices; a deformed octahedron [La2Ni4], and [La(Mg2Ni2] and [Ni4] tetrahedra. The overall chemical compositions can be presented as LaNi5H5.6/5.0 + 2*MgNi2H1.95/2.2 showing that the hydrogenation of the MgNi2 slab proceeds at mild H2/D2 pressure of just 20 bar. A partial filling by D of the four types of the tetrahedral interstices in the MgNi2 slab takes place, including [MgNi3] and [Mg2Ni2] tetrahedra.

  3. Effects of ZnO addition on mechanical properties of Bi{sub 1.84}Pb{sub 0.34}Sr{sub 1.91}Ca{sub 2.03}Cu{sub 3.06}O{sub 10} prepared by a wet technique

    Energy Technology Data Exchange (ETDEWEB)

    Karaca, I. [Department of Physics, Faculty of Science and Arts, Nigde University, 51200 Nigde (Turkey)], E-mail: ikaraca38@hotmail.com; Uzun, O.; Koelemen, U.; Yilmaz, F. [Department of Physics, Faculty of Science and Arts, Gaziosmanpasa University, 60240 Tokat (Turkey); Sahin, O. [Department of Physics, Faculty of Science and Arts, Mustafa Kemal University, 31034 Hatay (Turkey)

    2009-05-12

    In this study, ZnO molar wt% 0, 5, 10, 20, 30, and 50 added Bi{sub 1.84}Pb{sub 0.34}Sr{sub 1.91}Ca{sub 2.03}Cu{sub 3.06}O{sub 10} superconductors were prepared by wet technique. The experimental works consist of powder X-ray diffraction (XRD) for phase analyses and c-axes parameters, scanning electron microscopy (SEM) for microstructure examination, and microhardness measurements for mechanical properties. These measurements showed that Zn-added material, in comparison with the pure sample, had increased c-axes parameters and decreased grain size. In addition, the experimental results of microhardness measurements were analyzed using Oliver-Pharr model. It was observed that the change of indentation hardness (H{sub IT}) and reduced elastic modulus (E{sub r}) values showed an increasing trend with ZnO addition and exhibited peak load dependence (i.e., indentation size effect (ISE))

  4. Dicty_cDB: SSB191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available cDNA clone Gm-r1088-7599 3', mRNA sequence. 50 5e-04 2 AW738663 |AW738663.1 EST340090 tomato flower buds, anthesis, Cornell...quence. 44 0.027 2 AW737094 |AW737094.1 EST338521 tomato flower buds, anthesis, Cornell University Lycopersi...con esculentum cDNA clone cTOD2E1 5', mRNA sequence. 44 0.041 2 AW737942 |AW737942.1 EST339369 tomato flower buds, anthesis, Cornell

  5. 47 CFR 0.191 - Functions of the Bureau.

    Science.gov (United States)

    2010-10-01

    ... on waivers of rules; acting on applications for service and facility authorizations; compliance and... international monitoring, fixed and mobile direction-finding and interference resolution; and oversees... during non-business hours when the other Offices and Bureaus of the Commission are closed. Such...

  6. Dicty_cDB: SHE191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available strand read from insert in 3'HPRT insertion targeting and chromosome engineering clone MHPP186g09. 50 0.063 ...sert in 3'HPRT insertion targeting and chromosome engineering clone MHPP47e19. 50 0.063 1 CR034434 |CR034434....1 Forward strand read from insert in 3'HPRT insertion targeting and chromosome engineering clone MHPP47e19....ion targeting and chromosome engineering clone MHPP142o16. 50 0.063 1 dna update 2006. 2.10 Homology vs Prot...1 CR023465 |CR023465.1 Forward strand read from insert in 3'HPRT insertion targeting and chromosome engine

  7. 22 CFR 191.12 - Description of benefits.

    Science.gov (United States)

    2010-04-01

    ... taking advantage of the Act. (k) Further relief. Section 700 (50 U.S.C. App. 590) provides that a person... occupied for dwelling, business, or agricultural purpose, executed by persons who subsequently become... policy loan, except upon certain conditions, shall not exercise any right with respect to the...

  8. 19 CFR 191.193 - Application procedure for compliance program.

    Science.gov (United States)

    2010-04-01

    ..., address, IRS number (with suffix), and the type of business in which engaged, as well as the name(s) of... program, including the retention period and method (for example, paper, electronic, etc.); (4) A list...

  9. 49 CFR 191.7 - Addressee for written reports.

    Science.gov (United States)

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS... agency pursuant to a certification under section 5(a) of the Natural Gas Pipeline Safety Act of 1968...

  10. 44 CFR 206.191 - Duplication of benefits.

    Science.gov (United States)

    2010-10-01

    ... section 312 of the Stafford Act, entitled Duplication of Benefits. This section relates to assistance for...) Duplication when assistance under the Act is involved. If duplication is discovered, the Regional... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Duplication of benefits....

  11. Dicty_cDB: SFF191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 0 |BH134670.1 ENTOP40TR Entamoeba histolytica Sheared DNA Entamoeba histolytica g...enomic, DNA sequence. 42 1.5 1 AZ545420 |AZ545420.1 ENTDG15TR Entamoeba histolytica Sheared DNA Entamoeba hi...stolytica genomic, DNA sequence. 42 1.5 1 AZ670282 |AZ670282.1 ENTMN84TF Entamoeba histolytica Sheared DNA E...TR Entamoeba histolytica Sheared DNA Entamoeba histolytica genomic, DNA sequence. 42 1.5 1 AZ678163 |AZ67816...3.1 ENTKA17TF Entamoeba histolytica Sheared DNA Entamoeba histolytica genomic, DNA sequence. 42 1.5 1 dna up

  12. 19 CFR 19.1 - Classes of customs warehouses.

    Science.gov (United States)

    2010-04-01

    ... manufacture for home consumption or exportation of cigars in whole of tobacco imported from one country. (7... domestic consumption. (8) Class 8. Bonded warehouses established for the purpose of cleaning,...

  13. 19 CFR 191.51 - Completion of drawback claims.

    Science.gov (United States)

    2010-04-01

    ..., applicable import entry number(s), coding sheet unless the data is filed electronically, and evidence of... ratio for each line item. The value of each line item of entered merchandise subject to a merchandise processing fee is calculated (to four decimal places) by dividing the value of the line item subject to...

  14. Dicty_cDB: SHC191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available mRNA sequence. 56 0.001 1 CV682907 |CV682907.1 service43_H06_sjs2-16-2B11-T3 SJS Schistosoma japonicum cDNA,... mRNA sequence. 56 0.001 1 CV682854 |CV682854.1 service30_G09_sjs2-14-10C09-T3 SJ

  15. Oral pyogenic granuloma: a epidemiologic study of 191 cases

    Directory of Open Access Journals (Sweden)

    Thiago de Santana SANTOS

    2008-01-01

    Full Text Available Objectives: To evaluate the prevalence of pyogenic granuloma and compare the data obtained with those of other reports in the worldliterature. Methods: The study material was surveyed from the records of patients with diagnosis of oral pyogenic granuloma, at the Oral Pathology Laboratory of the School of Dentistry of the University of Pernambuco, in the period from January 1992 to March 2007 (15 years. The following indicators were analyzed: gender, age group, race, anatomic location, diameter of lesions and presence of symptomatology.Results: Among the 5007 records in the laboratory, 3.81% corresponded to lesions diagnosed as oral pyogenic granuloma, in which 19.9% of the patients were in the second decade of life, 40.1% were white, the gingiva was the most affected location (77.9% and lesion of smaller diameter (0.1 to 2 cm were those most observed at the initial diagnosis. Conclusion: The clinical-pathological characteristics of oral pyogenic granuloma in the studied population are similar to those of other studies in the literature

  16. Accelerated fatigue testing of LM 19.1 blades

    DEFF Research Database (Denmark)

    Kristensen, Ole Jesper Dahl; Jørgensen, E.

    2003-01-01

    material. In addition to the thermal imaging surveillance the blades were instrumented with strain gauges. This report presents the temperature duringtest, calibration test results, moment range measurements, strain statistics, thermal imaging registrations and a determination of the size and cause...

  17. Evaluation of Novel Wet Chemistry Separation and Purification Methods to Facilitate Automation of Astatine-­211 Isolation

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott [Univ. of Washington, Seattle, WA (United States)

    2016-07-19

    This research is a collaborative effort between the research groups of the PIs, Dr. D. Scott Wilbur in the Department of Radiation Oncology at the University of Washington (UW) and Matthew O’Hara at the Pacific Northwest National Laboratory (PNNL). In this report only those studies conducted at UW and the budget information from UW will be reported. A separate progress and financial report will be provided by PNNL. This final report outlines the experiments (Tasks) conducted and results obtained at UW from July 1, 2013 thru June 30, 2016 (2-­year project with 1 year no-­cost extension). The report divides the information on the experiments and results obtained into the 5 specific objectives of the research efforts and the Tasks within those objectives. This format is used so that it is easy to see what has been accomplished in each area. A brief summary of the major findings from the studies is provided below. Summary of Major Findings from Research/Training Activities at UW: Anion and cation exchange columns did not provide adequate 211At capture and/or extraction results under conditions studied to warrant further evaluation; PEG-­Merrifield resins containing mPEG350, mPEG750, mPEG2000 and mPEG5000 were synthesized and evaluated; All of the mPEG resins with different sized mPEG moieties conjugated gave similar 211At capture (>95%) from 8M HCl solutions and release with conc. NH4OH (~50-­80%), but very low quantities were released when NaOH was used as an eluent; Capture and release of 211At when loading [211At]astatate appeared to be similar to that of [211At]astatide on PEG columns, but further studies need to be conducted to confirm that; Capture of 211At on PEG columns was lower (e.g. 80-­90%) from solutions of 8M HNO3, but higher capture rates (e.g. 99%) can be obtained when 10M HNO3 is mixed with an equal quantity of 8M HCl; Addition of reductants to the 211At solutions did not appear to change the percent capture, but may have an effect on the % extracted; There was some indication that the PEG-­Merrifield resins could be saturated (perhaps with Bi) resulting in lower capture percentages, but more studies need to be done to confirm that; A target dissolution chamber, designed and built at PNNL, works well with syringe pumps so it can be used in an automated system; Preliminary semi-­automated 211At isolation studies have been conducted with full scale target dissolution and 211At isolation using a PEG column on the Hamilton automated system gave low overall recoveries, but HNO3 was used (rather than HCl) for loading the 211At and flow rates were not optimized; Results obtained using PEG columns are high enough to warrant further development on a fully automated system; Results obtained also indicate that additional studies are warranted to evaluate other types of columns for 211At separation from bismuth, which allow use of HNO3/HCl mixtures for loading and NaOH for eluting 211At. Such a column could greatly simplify the overall isolation process and make it easier to automate.

  18. Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

    Energy Technology Data Exchange (ETDEWEB)

    Green, Damian J.; Shadman, Mazyar; Jones, Jon C.; Frayo, Shani; Kenoyer, Aimee L.; Hylarides, Mark; Hamlin, Donald K.; Wilbur, D. Scott; Balkan, Ethan R.; Lin, Yukang; Miller, Brian W.; Frost, Sophia; Gopal, Ajay K.; Orozco, Johnnie J.; Gooley, Ted; Laird, Kelley L.; Till, B. G.; Back, Tom; Sandmaier, B. M.; Pagel, John M.; Press, Oliver W.

    2015-03-26

    Alpha emitting radionuclides release a large amount of energy within a few cell diameters and may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD) conditions in which micrometastatic disease satellites are broadly distributed. To evaluate this hypothesis, 211At conjugated 1F5 mAb (anti-CD20) was studied in both bulky lymphoma tumor xenograft and MRD animal models. Superior treatment responses to 211At conjugated 1F5 mAb were evident in the MRD setting. Lymphoma xenograft tumor bearing animals treated with doses of up to 48µCi of anti-CD20 211At-decaborate [211At-B10-1F5] experienced modest responses (0% cures but 2-3-fold prolongation of survival compared to negative controls). In contrast, 70% of animals in the MRD lymphoma model demonstrated complete eradication of disease when treated with 211At-B10-1F5 at a radiation dose that was less than one-third (15 µCi) of the highest dose given to xenograft animals. Tumor progression among untreated control animals in both models was uniformly lethal. After 130 days, no significant renal or hepatic toxicity is observed in the cured animals receiving 15 µCi of 211At-B10-1F5. These findings suggest that in a MRD lymphoma model, where isolated cells and tumor microclusters prevail, α-emitters may be uniquely efficacious.

  19. 40 CFR Appendix A to Part 191 - Table for Subpart B

    Science.gov (United States)

    2010-07-01

    ...-90 1,000 Technetium-99 10,000 Thorium-230 or -232 10 Tin-126 1,000 Uranium-233, -234, -235, -236, or... from (a) and (b) of Note 1 shall no longer be used. Instead, the units of waste defined in (c) and...

  20. SU-E-J-191: Motion Prediction Using Extreme Learning Machine in Image Guided Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Jia, J; Cao, R; Pei, X; Wang, H; Hu, L [Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); Engineering Technology Research Center of Accurate Radiotherapy of Anhui Province, Hefei 230031 (China); Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, SuZhou (China)

    2015-06-15

    Purpose: Real-time motion tracking is a critical issue in image guided radiotherapy due to the time latency caused by image processing and system response. It is of great necessity to fast and accurately predict the future position of the respiratory motion and the tumor location. Methods: The prediction of respiratory position was done based on the positioning and tracking module in ARTS-IGRT system which was developed by FDS Team (www.fds.org.cn). An approach involving with the extreme learning machine (ELM) was adopted to predict the future respiratory position as well as the tumor’s location by training the past trajectories. For the training process, a feed-forward neural network with one single hidden layer was used for the learning. First, the number of hidden nodes was figured out for the single layered feed forward network (SLFN). Then the input weights and hidden layer biases of the SLFN were randomly assigned to calculate the hidden neuron output matrix. Finally, the predicted movement were obtained by applying the output weights and compared with the actual movement. Breathing movement acquired from the external infrared markers was used to test the prediction accuracy. And the implanted marker movement for the prostate cancer was used to test the implementation of the tumor motion prediction. Results: The accuracy of the predicted motion and the actual motion was tested. Five volunteers with different breathing patterns were tested. The average prediction time was 0.281s. And the standard deviation of prediction accuracy was 0.002 for the respiratory motion and 0.001 for the tumor motion. Conclusion: The extreme learning machine method can provide an accurate and fast prediction of the respiratory motion and the tumor location and therefore can meet the requirements of real-time tumor-tracking in image guided radiotherapy.

  1. 15 CFR 19.1 - What definitions apply to the regulations in this Part?

    Science.gov (United States)

    2010-01-01

    ... Institute of Standards and Technology, and the National Technical Information Service). Creditor agency... bureaus currently include the Bureau of Industry and Security, the Economics and Statistics Administration... Oceanic and Atmospheric Administration, the National Telecommunications and Information...

  2. Stratospheric Determination of Effective Photodissociation Cross Sections for Molecular Oxygen: 191-204 nm

    Science.gov (United States)

    1983-10-20

    near 200 nm, is greater than expected, indicating that the recoin- mended 6 02 Herzberg continuum cross sections may be too large. Photo- -~ chemical...ToT(A) convolved with altitude-dependent effective absorption cross sections, t’eff(ZAX)9󈧎 (Allen & Frederick , 1982, ref. 10, will subsequently be 1...The preliminary data from that flight will be used to augment this study and tighten the error estimates. IV. Theory: As Allen and Frederick 10

  3. SU-E-T-191: First Principle Calculation of Quantum Yield in Photodynamic Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Abolfath, R; Guo, F; Chen, Z; Nath, R [Yale New Haven Hospital, New Haven, CT (United States)

    2014-06-01

    Purpose: We present a first-principle method to calculate the spin transfer efficiency in oxygen induced by any photon fields especially in MeV energy range. The optical pumping is mediated through photosensitizers, e.g., porphyrin and/or ensemble of quantum dots. Methods: Under normal conditions, oxygen molecules are in the relatively non-reactive triplet state. In the presence of certain photosensitizer compounds such as porphyrins, electromagnetic radiation of specific wavelengths can excite oxygen to highly reactive singlet state. With selective uptake of photosensitizers by certain malignant cells, photon irradiation of phosensitized tumors can lead to selective killing of cancer cells. This is the basis of photodynamic therapy (PDT). Despite several attempts, PDT has not been clinically successful except in limited superficial cancers. Many parameters such as photon energy, conjugation with quantum dots etc. can be potentially combined with PDT in order to extend the role of PDT in cancer management. The key quantity for this optimization is the spin transfer efficiency in oxygen by any photon field. The first principle calculation model presented here, is an attempt to fill this need. We employ stochastic density matrix description of the quantum jumps and the rate equation methods in quantum optics based on Markov/Poisson processes and calculate time evolution of the population of the optically pumped singlet oxygen. Results: The results demonstrate the feasibility of our model in showing the dependence of the optical yield in generating spin-singlet oxygen on the experimental conditions. The adjustable variables can be tuned to maximize the population of the singlet oxygen hence the efficacy of the photodynamic therapy. Conclusion: The present model can be employed to fit and analyze the experimental data and possibly to assist researchers in optimizing the experimental conditions in photodynamic therapy.

  4. 19 CFR Appendix A to Part 191 - General Manufacturing Drawback Rulings

    Science.gov (United States)

    2010-04-01

    ... shall include the following information: 1. Name and address of manufacturer or producer; 2. IRS... manufacturing process. 2. Appearing-in method The appearing in basis may not be used if multiple products...

  5. 34 CFR 403.191 - What are the requirements for program evaluation?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are the requirements for program evaluation? 403... program evaluation? (a)(1) Beginning in the 1992-1993 school year, each recipient of financial assistance... program listed in § 403.130 to support the cost of conducting the evaluation required under paragraphs...

  6. Yeast Interacting Proteins Database: YBL045C, YPR191W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available Rows with this prey as prey Rows with this prey as prey (2) Rows with this prey as bait Rows with this prey as bait (1) Literature... on bait (YPD) 27 Literature on prey (YPD) 23 Literature sh...ared by bait and prey 14 Literature sharing score 89 CuraGen (0 or 1) 0 S. Fields (0 or 1) 0 Association (0

  7. 函大商学論究19-1表紙

    OpenAIRE

    1983-01-01

    Introduction to the "Linear Programming"--Outline of the "Simplex Method" of the "Linear Programming"-2- 荒木 秀弥 p69-93, 1983-10 バックスタ-・インフレ-ション会計論の一考察 井口 伸 p1-16, 1983-10 資金計算書の諸類型 新谷 典彦 p41-67, 1983-10 経済学,常識入門-4- 荒木 秀弥 p95-104, 1983-10 Zepeda v.Zepeda事件の教訓--「英米不法行為法における私生子」・再論 蘇田 三千穂 p17-40, 1983-10

  8. 10 CFR Appendix C to Part 20 - Quantities 1 of Licensed Material Requiring Labeling

    Science.gov (United States)

    2010-01-01

    ... Polonium-205 1,000 Polonium-207 1,000 Polonium-210 0.1 Astatine-207 100 Astatine-211 10 Radon-220 1 Radon-222 1 Francium-222 100 Francium-223 100 Radium-223 0.1 Radium-224 0.1 Radium-225 0.1 Radium-226...

  9. Effects of Prior Aging at 191 C on Creep Response of IM7/BMI 5250-4

    Science.gov (United States)

    2007-06-01

    as 1500 Mayans were using rubber in their everyday lives. In 1839, Charles Goodyear discovered vulcanization, the adding of sulfur to natural rubber... civil aircraft applications. (33:437) Boeing looks to recapture the lead on composite materials usage with its 787 model. The 787 will become the...sets pace for composite usage in large civil aircraft May 2005 http://www.compositesworld.com/hpc/issues/2005/May/865/3 37. Ruggles-Wrenn, M.B

  10. Identification of protein-damaging mutations in 10 swine taste receptors and 191 appetite-reward genes

    DEFF Research Database (Denmark)

    Clop, Alex; Sharaf, Abdoallah; Castelló, Anna

    2016-01-01

    BACKGROUND: Taste receptors (TASRs) are essential for the body's recognition of chemical compounds. In the tongue, TASRs sense the sweet and umami and the toxin-related bitter taste thus promoting a particular eating behaviour. Moreover, their relevance in other organs is now becoming evident...

  11. 19 CFR 191.185 - Unused merchandise drawback and merchandise not conforming to sample or specification, shipped...

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Unused merchandise drawback and merchandise not conforming to sample or specification, shipped without consent of the consignee, or found to be defective as... conforming to sample or specification, shipped without consent of the consignee, or found to be defective...

  12. Dollar Summary of Federal Supply Classification and Service Category by Company. Part 4 (Y191-Z300)

    Science.gov (United States)

    1991-01-01

    i ci i 4 a i : i 0 : 0, 0 41 z 0 ci a 0: 0 0 0 a toe a I c i c c c c c c m i c c c c c c c c c c c c c c c c w~~ Iawa 0 00 0 000 0 0 a0 00 0 0 0 0...JS0 a m m m 0 ( us a4 us I n % n t n C A c p t 0 n 41 4s i aa-4 -v4 -.4 -4 -.4 -4 .4 -4 -4 -4 ..4 .4 -4 -4 -4 -4 -4 -.4 -.4 1-.4 4 -.4 -.4 a’ a) 0 Iawa

  13. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 2: Appendices, AAC, BECR, BH

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    This report describes the conceptual design of a system the Department of Energy (DOE) may implement for compliance with the requirement to control access to the disposal site. In addition, this report addresses the scheduling process for control of inspection, maintenance, and periodic reporting related to Long Term Monitoring which addresses the monitoring of disposal system performance, environmental monitoring in accordance with the Consultation and Cooperation Agreement between the DOE and the state of New Mexico, and evaluation of testing activities related to the Permanent Marker System design. In addition to access control addressed by this report, the controlling or cleaning up of releases from the site is addressed in the Conceptual Decontamination and Decommissioning Plan. The monitoring of parameters related to disposal system performance is addressed in the Long Term Monitoring Design Concept Description. Together, these three documents address the full range of active institutional controls planned after disposal of the TRU waste in the WIPP repository.

  14. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 7: Appendix GCR Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    This report contains the second part of the geological characterization report for the Waste Isolation Pilot Plant. Both hydrology and geochemistry are evaluated. The following aspects of hydrology are discussed: surface hydrology; ground water hydrology; and hydrology drilling and testing. Hydrologic studies at the site and adjacent site areas have concentrated on defining the hydrogeology and associated salt dissolution phenomena. The geochemical aspects include a description of chemical properties of geologic media presently found in the surface and subsurface environments of southeastern New Mexico in general, and of the proposed WIPP withdrawal area in particular. The characterization does not consider any aspect of artificially-introduced material, temperature, pressure, or any other physico-chemical condition not native to the rocks of southeastern New Mexico.

  15. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 6: Appendix GCR Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    The Geological Characterization Report (GCR) for the WIPP site presents, in one document, a compilation of geologic information available to August, 1978, which is judged to be relevant to studies for the WIPP. The Geological Characterization Report for the WIPP site is neither a preliminary safety analysis report nor an environmental impact statement; these documents, when prepared, should be consulted for appropriate discussion of safety analysis and environmental impact. The Geological Characterization Report of the WIPP site is a unique document and at this time is not required by regulatory process. An overview is presented of the purpose of the WIPP, the purpose of the Geological Characterization Report, the site selection criteria, the events leading to studies in New Mexico, status of studies, and the techniques employed during geological characterization.

  16. AB191. The roles of polyuria and hyperglycemia in bladder dysfunction in long-term diabetic rats

    Science.gov (United States)

    Xiao, Nan; Wang, Zhiping; Wang, Jiaji; Mi, Jun; Liu, Guiming

    2014-01-01

    Aims of study Diabetic bladder dysfunction (DBD), a collective description of clinical symptoms including decreased sensation, increased capacity, poor emptying, and also detrusor overactivity, is among the most common and costly complications of diabetes mellitus (DM). It is estimated that DBD occurs in approximately 87% of individuals diagnosed with DM, and substantially affects quality of life. Yet, little is known about the pathogenic mechanisms of DBD. Unlike other organs, the bladder experiences not only hyperglycemia, but also an increased volume of urine in DM. To aid in our knowledge of the pathophysiology of DBD and to aid development of specific treatments, identification of individual contributions of polyuria and hyperglycemia in the DBD is essential. Materials and methods Seventy two female Sprague-Dawley rats were divided into six groups: age-matched controls (control), sham urinary diversion (sham), urinary diversion (UD), streptozotocin-induced diabetics after sham urinary DM, streptozotocin-induced diabetics after urinary diversion (UD + DM), and 5% sucrose-induced diuretics after sham urinary diversion (DIU). UD was performed 10 days before diabetes induction by surgical disconnection of the ureters from the bladder and implantation to uterine cervix. Each group was subsequently evaluated 20 weeks after diabetes or diuresis induction. Twenty-four hour drinking and voided volumes were measured. Conscious cystometry (CMG) was examined. The bladders were harvested for histological examination and quantification of smooth muscle, urothelium, and collagen. The expressions of oxidative stress-related proteins, nitrotyrosine and manganese superoxide dismutase (MnSOD), in bladder were examined. Results Diabetes and diuresis caused increases in drinking volume, voided volume and bladder weight. The bladder weight decreased in the UD and UD + DM group. CMG showed increased inter-contractile intervals, voided volume and compliance in DIU and DM group, whereas decreased in the UD, and further in UD + DM group. The total tissue area, the tissue area of smooth muscle and urethelium increased in DIU and DM group, whereas decreased in UD and UD + DM group. As a percentage of the total cross sectional tissue area, collagen decreased in DIU and DM group, but increased in UD and UD + DM groups; smooth muscle and urothelium decreased in UD and UD + DM groups. The expression of nitrotyrosine and MnSOD increased in the DM and the UD + DM groups compared with other four groups. Conclusions Polyuria and hyperglycemia contribute differently in DBD. Polyuria induced significant bladder hypertrophy, whereas chronic hyperglycemia induces oxidative stress in bladder, which may play an important role in the later stage of DBD.

  17. Discourse analysis of the National Policy for Health Promotion - doi:10.5020/18061230.2011.p191

    Directory of Open Access Journals (Sweden)

    Aline Raddatz

    2012-01-01

    Full Text Available Objective: To analyze the characteristics of the perspectives of Health Promotion present in the proposals of the actual National Policy for Health Promotion (PNPS. Methods: We conducted a qualitative, exploratory and documental study using the methodological procedures of the Collective Subject Discourse (CSD in the period of October 2009 to June 2010. Results: There were five Central-Ideas related to three different Anchorages. The DSC connected to Central-Ideas: (1 Spreading and introducing the PNPS; (3 Organizing and introducing proceedings targeting individual risk factors; and (4 Monitoring and controlling damages and risk factor, showed to be linked to Behavioral and/or Biomedical Approaches of Health Promotion. The DSC connected to Central-Ideas: (2 Discussing and Evaluating the PNPS and (5 Organizing and introducing proceedings for sustainable development reflected a Socio-Environmental Approach of Health Promotion. Conclusion: It was possible to verify the complexity of a set of proposals that reflect different perspectives of Health Promotion, considering that the Socio-Environmental approach, although not predominant in the PNPS, can be the most effective and according to the Unified Health System (SUS

  18. Corrigendum to "The viscosity of planetary tholeiitic melts: A configurational entropy model" [Geochim. Cosmochim. Acta 191 (2016) 277-299

    Science.gov (United States)

    Sehlke, Alexander; Whittington, Alan G.

    2017-01-01

    The authors regret some of the information presented in the original article was incorrect. The coefficients for five sub-parameters (s1 to s5) to calculate Sconf in Table 6 are incorrect, which resulted in lower Sconf values, affecting the viscosity prediction near the glass transition temperature (Tg). We provide the correct coefficients (s1 to s5) for in Table 6.

  19. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 3: Appendix BIR Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    The Waste Isolation Pilot Plant (WIPP) Transuranic Waste Baseline Inventory Report (WTWBIR) establishes a methodology for grouping wastes of similar physical and chemical properties, from across the US Department of Energy (DOE) transuranic (TRU) waste system, into a series of ``waste profiles`` that can be used as the basis for waste form discussions with regulatory agencies. The majority of this document reports TRU waste inventories of DOE defense sites. An appendix is included which provides estimates of commercial TRU waste from the West Valley Demonstration Project. The WIPP baseline inventory is estimated using waste streams identified by the DOE TRU waste generator/storage sites, supplemented by information from the Mixed Waste Inventory Report (MWIR) and the 1994 Integrated Data Base (IDB). The sites provided and/or authorized all information in the Waste Stream Profiles except the EPA (hazardous waste) codes for the mixed inventories. These codes were taken from the MWIR (if a WTWBIR mixed waste stream was not in MWIR, the sites were consulted). The IDB was used to generate the WIPP radionuclide inventory. Each waste stream is defined in a waste stream profile and has been assigned a waste matrix code (WMC) by the DOE TRU waste generator/storage site. Waste stream profiles with WMCs that have similar physical and chemical properties can be combined into a waste matrix code group (WMCG), which is then documented in a site-specific waste profile for each TRU waste generator/storage site that contains waste streams in that particular WMCG.

  20. Protein (Viridiplantae): 255606958 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available 987:191 3988:191 conserved hypothetical protein, partial Ricinus communis MQDPSPQDALLENKVTGYMEKRERQMSSKVTSQWVPAVGREENTKGDLAEILVEIEHMEKDAHSSFSLVEGRRGLHAENGYQHSDEVINQKKESSVIGQQKE ...

  1. "La mujer del porvenir": raíces iiitelectuales y alcances del pensamiento feminista de Hermila Galindo, 191 5-1919

    Directory of Open Access Journals (Sweden)

    Laura Orellana Trinidad

    2001-01-01

    Full Text Available Este artículo analiza las ideas sobre la emancipación de la mujer elaboradas por HermilaGalindo, en la famosa y polémica ponencia que envió al Primer Congreso Feminista de Yucaián en 1916, "Lamuier en el ~owenir". En estas ~áginas se exa- . - mina la novedosa construcción femenina propuestaen su disertación, asi como las diversas corrientes teóricas de la época que influyeron dicho imaginario.

  2. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 8: Appendices HYDRO, IRD, LTM, NUTS, PAR, PMR, QAPD, RBP

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    Geohydrologic data have been collected in the Los Medanos area at the US Department of Energy`s proposed Waste Isolation Pilot Plant (WIPP) site in southeastern New Mexico since 1975 as part of a study evaluating the feasibility of storing defense-associated nuclear wastes within the bedded salt of the Salado Formation of Permian age. Drilling and hydrologic testing have identified three principal water-bearing zones above the Salado Formation and one below that could potentially transport wastes to the biosphere if the proposed facility were breached. The zones above the Salado are the contact between the Rustler and Salado Formations and the Culebra and Magenta Dolomite Members of the Rustler Formation of Permian age. The zone below the Salado Formation consists of channel sandstones in the Bell Canyon Formation of the Permian Delaware Mountain Group. Determinations of hydraulic gradients, directions of flow, and hydraulic properties were hindered because of the negligible permeability of the water-bearing zones. Special techniques in drilling, well completion, and hydraulic testing have been developed to determine the hydrologic characteristics of these water-producing zones.

  3. 75 FR 43813 - Modification of VOR Federal Airways V-82, V-175, V-191, and V-430 in the Vicinity of Bemidji, MN

    Science.gov (United States)

    2010-07-27

    ... range/tactical air navigation (VORTAC) name and identifier to the Adders VORTAC (AXC). The DEC VORTAC... change to Adders VORTAC. The Decatur VORTAC and Decatur Airport share the same name and facility... possibility of confusion, and a potential flight safety issue, the Decatur VORTAC is being renamed the...

  4. Worldwide trends in blood pressure from 1975 to 2015 : a pooled analysis of 1479 population-based measurement studies with 19.1 million participants

    OpenAIRE

    Zhou, Bin; Bentham, James; Di Cesare, Mariachiara; Bixby, Honor; Danaei, Goodarz; Cowan, Melanie J.; Paciorek, Christopher J.; Singh, Gitanjali; Hajifathalian, Kaveh; James E Bennett; Taddei, Cristina; Bilano, Ver; Carrillo-Larco, Rodrigo M.; Djalalinia, Shirin; Khatibzadeh, Shahab

    2017-01-01

    Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured ...

  5. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants

    OpenAIRE

    Zhou, Bin; Bentham, James; Di Cesare, Mariachiara; Bixby, Honor; Cowan, Melanie J.; Paciorek, Christopher J.; Singh, Gitanjali; Hajifathalian, Kaveh; James E Bennett; Taddei, Cristina; Bilano, Ver; Carrillo-Larco, Rodrigo M.; Khatibzadeh, Shahab; Lugero, Charles; Zhang, Wan Zhu

    2017-01-01

    Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured ...

  6. Development of Optical Fiber Technology in Poland, International Journal of Electronics and Telecommunication, vol. 57, no 2, pp.191-197, July 2011

    CERN Document Server

    Dorosz, J

    2011-01-01

    In this paper, the authors, chairmen of the 13th Conference on Optical Fibers and Their Applications OFA2011, and editors of the conference proceedings summarize the development of optical fiber technology in Poland (during the period of 2009- 2011) on the basis of papers presented there and consecutively published in this volume. The digest is thus not full but covers the periodically presented material every 18 months during the meetings on optical fibers in Białystok-Białowie˙za and Lublin- Krasnobród. OFC systems are developed for HEP experiments and accelerators. OFC systems are also developed for virtual atomic clocks. EuCARD information presentation was organized during this meeting. Keywords— optical fibers, optical communication systems, photonic sources and detectors, photonic sensors, integrated optics, photonics applications, photonic materials.

  7. Molecular Design of Crown Ethers. 191. Synthesis of Novel Disulfide- and Diselenide-Bridged Bis (benzo-12-crown-4)s and their Ag+ Selective Electrode Properties

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Two novel heteroatom-bridged bis (benzo-12-crown-4 ether)s, i.e. bis [2-nitro-4,5-(1,4,7,10-tetraoxadecamethylene)phenyl] disulfide 1 and diselenide 2, have been synthesized. X-ray crystallographic structure was obtained for 1. Ion selective electrodes (ISE) for Ag+, containing 1 and 2 in PVC membrane as neutral carriers, were prepared, and their selectivity coefficients for Ag+ (KpolAg,M) were determined against other heavy metal ions, alkali and alkaline-earth metal ions, and ammonium ion. These ISEs showed excellent Ag+ selectivities, log (KpolAg,M) -3.8, against most of the interfering cations examined, except for Hg+.

  8. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 9: Appendices RM, SCR, SER, SUM, WRAC

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    The Rock Mechanics Program is important to the establishment of a radioactive waste repository in salt because rock mechanics deals with the prediction of creep closure and eventual encapsulation of the waste. The intent of this paper is to give the current status of the program. This program consists of three major modeling efforts: continuum creep, fracture, and the disturbed rock zone. These models, together with laboratory material parameters, plastic flow potentials, initial and boundary input data, and other peripheral information forms the predictive technology. The extent to which the predictive technology is validated against in situ test data adds certainty to the method. Application of the technology is through simulations of the test results, design, or performance using numerical codes. In summary, the predictive capabilities are technically sound and reasonable. The current status of the program is that which would be advanced for compliance.

  9. Mecanismo de activación de P191NK4d y su papel como factor neuroprotector frente a la injuria genotóxica

    OpenAIRE

    Ogara, María Florencia

    2012-01-01

    La permanencia de la mayoría de las neuronas durante toda la vida del organismo necesaria para mantener sus funciones, y el hecho de que estas células no se dividan luego del desarrollo sugieren que, durante la evolución, se ha ejercido una fuerte presión sobre el sistema nervioso de modo de desarrollar diversos mecanismos que lo protejan contra la muerte celular. Las dramáticas consecuencias de la neurodegeneración enfatizan la importancia de estos mecanismos que promueven la supervivencia y...

  10. Factores pronósticos del carcinoma oral de células escamosas en estadio avanzado. Estudio clínico de 191 casos

    OpenAIRE

    Díaz Fernández, José María

    2013-01-01

    El carcinoma oral de células escamosas es el tumor epitelial maligno más frecuente en la cavidad oral y territorio maxilofacial, representando un 90-95% de los tumores malignos de esta localización, con una incidencia variable según el área geográfica, así en Estados Unidos y Europa presenta una incidencia en torno al 2-4%, mientras que en Asia se cifra en aproximadamente un 30%, probablemente motivado por diferentes hábitos tabáquicos y nutricionales. El paciente tipo es un varón entre lo...

  11. Rapid needle-out patient-rollover approach after cone beam CT-guided lung biopsy: effect on pneumothorax rate in 1,191 consecutive patients

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jung Im [Seoul National University College of Medicine, Department of Radiology, Jongno-gu, Seoul (Korea, Republic of); Seoul National University Medical Research Center, Institute of Radiation Medicine, Seoul (Korea, Republic of); Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Park, Chang Min; Goo, Jin Mo [Seoul National University College of Medicine, Department of Radiology, Jongno-gu, Seoul (Korea, Republic of); Seoul National University, Cancer Research Institute, Seoul (Korea, Republic of); Lee, Sang Min [Seoul National University College of Medicine, Department of Radiology, Jongno-gu, Seoul (Korea, Republic of)

    2015-07-15

    To investigate the effect of rapid needle-out patient-rollover approach on the incidence of pneumothorax and drainage catheter placement due to pneumothorax in C-arm Cone-beam CT (CBCT)-guided percutaneous transthoracic needle biopsy (PTNB) of lung lesions. From May 2011 to December 2012, 1227 PTNBs were performed in 1191 patients with a 17-gauge coaxial needle. 617 biopsies were performed without (conventional-group) and 610 with rapid-rollover approach (rapid-rollover-group). Overall pneumothorax rates and incidences of pneumothorax requiring drainage catheter placement were compared between two groups. There were no significant differences in overall pneumothorax rates between conventional and rapid-rollover groups (19.8 % vs. 23.1 %, p = 0.164). However, pneumothorax rate requiring drainage catheter placement was significantly lower in rapid-rollover-group (1.6 %) than conventional-group (4.2 %) (p = 0.010). Multivariate analysis revealed male, age > 60, bulla crossed, fissure crossed, pleura to target distance > 1.3 cm, emphysema along needle tract, and pleural punctures ≥ 2 were significant risk factors of pneumothorax (p < 0.05). Regarding pneumothorax requiring drainage catheter placement, fissure crossed, bulla crossed, and emphysema along needle tract were significant risk factors (p < 0.05), whereas rapid-rollover approach was an independent protective factor (p = 0.002). The rapid needle-out patient-rollover approach significantly reduced the rate of pneumothorax requiring drainage catheter placement after CBCT-guided PTNB. (orig.)

  12. An Ultra-Low Phase Noise Class-F 2 CMOS Oscillator With 191 dBc/Hz FoM and Long-Term Reliability

    NARCIS (Netherlands)

    Babaie, M.; Staszewski, R.B.

    2015-01-01

    In this paper, we propose a new class of operation of an RF oscillator that minimizes its phase noise. The main idea is to enforce a clipped voltage waveform around the LC tank by increasing the second-harmonic of fundamental oscillation voltage through an additional impedance peak, thus giving rise

  13. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 5: Appendices D and D, DEF, FAC

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    This plan serves to describe the objectives of decommissioning for the Waste Isolation Pilot Plant (WIPP), identifies the elements necessary to accomplish the decommissioning, and defines the steps to execute those elements in a safe and environmentally sound manner. The plan provides a strategy for progressing from the final actions of the Disposal Phase, through the Decontamination and Decommissioning Phase, and into the initiation of the Long-Term Monitoring Phase. This plan describes a sequence of events for decontamination of the WIPP facilities and structures used to manage and contain TRU and TRU mixed waste during the receipt and emplacement operations. Alternative methods of decontamination are provided where practical. The methods for packaging and disposal of the waste generated (derived waste) during this process are discussed. The best available technology at the time of this plan`s development, may become outmoded by future technology and alternative strategies. If alternative technologies are identified the affected stakeholder(s), the Secretary of the Interior and the State will be consulted prior to implementation.

  14. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity...

  15. Successful radioimmunotherapy of established syngeneic rat colon carcinoma with 211At-mAb

    DEFF Research Database (Denmark)

    Eriksson, Sophie E; Bäck, Tom; Elgström, Erika

    2013-01-01

    Most carcinomas are prone to metastasize despite successful treatment of the primary tumor. One way to address this clinical challenge may be targeted therapy with α-emitting radionuclides such as astatine-211 (211At). Radioimmunotherapy utilizing α-particle emitting radionuclides is considered...... colon carcinoma with tumor diameters of approximately 10 mm....

  16. Physical trajectory profile data from glider unit_191 deployed by University of Alaska - Fairbanks in the Southern Oceans from 2015-01-05 to 2015-02-26 (NCEI Accession 0145717)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this glider mission is to do along canyon transects of Palmer Deep within the operating CODAR fields off of Anvers Island. This multi-platform field...

  17. Enhanced 1-m Composite Grayscale GeoTIFF Image of the Sidescan-Sonar Data From NOAA Survey H11076 of the Sea Floor in Quicks Hole, MA (H11076_UTM19_1MRSSS.TIF, UTM Zone 19)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The U.S. Geological Survey (USGS), in cooperation with the National Oceanic and Atmospheric Administration (NOAA) and the Massachusetts Office of Coastal Zone...

  18. « Frontiers and Wars: the Opium Economy in Afghanistan ». Journal of Agrarian Change, vol. 5, n° 42, 2005, pp. 191-216.

    OpenAIRE

    VAN ENGELAND, Anicée

    2007-01-01

    Cet article s’attache à décrire l’évolution de l’économie de l’opium en Afghanistan et examine les facteurs de résurgence depuis la chute des Talibans. L’A. analyse les causes historiques de la culture du pavot en relation avec les mouvements de frontières et les tentatives de cristallisation d’un État afghan ainsi que les échecs. Ces espaces de frontières que l’A. décrit comme non-étatiques dans le cas afghan ont facilité les trafics. L’A. analyse ensuite les dynamiques contemporaines de la ...

  19. Reply to comment on: Lawrence, J.A., Mortimore, R.N., Stone, K.J., and Busby, J.P., 2013. Sea saltwater weakening of chalk and the impact on cliff instability. Geomorphology 191, 14-22

    Science.gov (United States)

    Lawrence, James A.; Mortimore, Rory N.

    2015-02-01

    We are grateful to Dornbusch (2014) for the opportunity to clarify the role we propose for salt water weakening of the chalk and its potential importance as a mechanism contributing to cliff instability. Dornbusch's argument is based largely on a single comment "This work challenges the established view by identifying the role of salt from seawater in the degradation of porous rocks in coastal environments as a third and potentially the most important mechanism leading to chalk cliff collapse" (Lawrence et al., 2013: 15). This was not intended as a "conclusion" as suggested by Dornbusch (2014) but is rather a qualitative introductory statement highlighting the potential importance of the salt water weakening process in coastal cliff instability. The actual conclusions of the work are not challenged by Dornbusch (2014).

  20. Multibeam collection for KN191: Multibeam data collected aboard Knorr from 2007-08-28 to 2007-09-14, departing from Woods Hole, MA and returning to Woods Hole, MA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set is part of a larger set of data called the Multibeam Bathymetry Database (MBBDB) where other similar data can be found at...

  1. Basic residues in the 74-83 and 191-198 segments of protein kinase CK2 catalytic subunit are implicated in negative but not in positive regulation by the beta-subunit

    DEFF Research Database (Denmark)

    Sarno, S; Vaglio, P; Marin, O;

    1997-01-01

    by the beta-subunit many fold more than that of alpha wild type, while extrastimulation by beta mutant D55L56E57A, observable with alpha wild type, is abolished with these mutants. These data support the conclusion that down regulation by the acidic residues clustered in the N-terminal moiety of beta...... sensitive to inhibition by either beta-subunit or its N-terminal, CK2beta-(1-77)-peptide, while its stimulation by the C-terminal peptide, CK2beta-(155-215), is comparable to that of alpha wild type. These observations suggest an indirect role of Val66 in conferring to the alpha-subunit a conformation less...

  2. Estudo comparativo do desenvolvimento sensório-motor de recém-nascidos prematuros da unidade de terapia intensiva neonatal e do método canguru - doi:10.5020/18061230.2005.p191

    Directory of Open Access Journals (Sweden)

    Luciana Andrade da Mota

    2012-01-01

    Full Text Available O Método Canguru é uma alternativa ao método tradicional de assistência a bebês prematuros de baixo peso, que preconiza o contato pele a pele precoce, entre mãe e filho, 24 horas por dia, garantindo-lhes estímulos sensoriais e motores e maior participação dos pais no cuidado de seu bebê. A Unidade de Terapia Intensiva (UTI Neonatal é destinada ao tratamento de recém-nascidos prematuros com algum problema ao nascer. Objetivou-se comparar o desenvolvimento sensório-motor de recém-nascidos prematuros (RNPt da UTI Neonatal e do Método Canguru. Realizou-se um estudo comparativo, prospectivo e observacional, no Hospital Geral Dr. César Cals, em Fortaleza – CE, de agosto a outubro de 2004, com 14 RNPt, sendo 07 de cada grupo, com peso inferior a 2000g e idade gestacional entre 30 e 37 semanas. A avaliação foi semanal até a alta hospitalar ou até completarem a idade corrigida de 40 semanas, pelo método Dubowitz e Amiel-Tison, com análise de tônus muscular, respostas sensório-motoras, ganho de peso e tempo de internação. Como resultado, observou-se que os bebês do Método Canguru apresentaram melhores respostas sensório-motoras, comprovadas a partir da constatação de um menor grau de estresse, melhores respostas reflexas, movimentação espontânea e tônus muscular, e menor tempo de internação, permanecendo mais tempo em estado de alerta e interagindo bem com o ambiente e a mãe. Conclui-se que o Método Canguru mostrou-se uma alternativa mais eficaz de assistência a RNPt de baixo peso, pois proporcionou melhores resultados quanto às atividades sensório-motor dos bebês, se comparados à UTI Neonatal.

  3. Catherine Halpern, Michèle Bitton, Lilith, l’épouse de Satan, Paris, Larousse, coll. « Dieux, Mythes et Héros », 2010, 191 p.

    Directory of Open Access Journals (Sweden)

    Guillaume Roucoux

    2011-10-01

    Full Text Available Lilith, l’épouse de Satan est la quatrième figure féminine à s’inscrire dans la collection de « Dieux, Mythes & Héros » qui ne cache pas « le caractère profondément masculin de la mythologique en général » (p. 167, pour mieux lui résister. Ce portrait en six chapitres, dressé par la journaliste Catherine Halpern et la sociologue Michèle Bitton à partir de textes théologiques judéo-chrétiens et d’analyses scientifiques, nous donne à voir une Lilith plurielle mais dont « la plus grande partie ...

  4. A summary of the models used for the mechanical response of disposal rooms in the Waste Isolation Pilot Plant with regard to compliance with 40 CFR 191, Subpart B

    Energy Technology Data Exchange (ETDEWEB)

    Butcher, B.M.; Mendenhall, F.T.

    1993-08-01

    A summary is presented of the results of a number of studies conducted prior to March 1992 that have led to a conceptual model describing how the porosity (and therefore the permeability) of waste and backfill in a Waste Isolation Pilot Plant disposal room changes with time and also describes how results from calculations involving mathematical models of these processes are used to provide input into performance assessment of the repository. Included in the report are descriptions of essential material response or constitutive models that include the influence of gas generation and the response of simple gas-pressurized cracks and fractures in salt, marker beds, and clay seams. Two-dimensional versus three-dimensional disposal room configurations and descriptions of the differences between numerical codes are also discussed. Calculational results using the mathematical models for disposal room response are described, beginning with closure of empty rooms and becoming progressively more complex. More recent results address some of the effects of gas generation in a room containing waste and backfill and intersected by a gas permeable marker bed. Developments currently in progress to improve the evaluation of the disposal room performance are addressing the coupling between brine flow and closure and the two-dimensional capability for analyzing a complete panel of rooms. Next, a method is described for including disposal room closure results into performance assessment analyses that determine if the repository is in compliance with regulatory standards. The coupling is accomplished using closure surfaces that describe the relationship among porosity, total amount of gas in the repository, and time. A number of conclusions about room response and recommendations for further work are included throughout the report.

  5. Dicty_cDB: Contig-U08414-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available gtaagtggtatttcaaaagcatgntnccttttaaat 190 Query: 191 nnaattttcanagcttctcccgacactanaggatttgcnattnnatgtggtactng...ggat 250 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 191 nnaattttcan...|||||||||||||||||||||||||||||||||| Sbjct: 95 naattttcanagcttctcccgacactanaggatttg...|||||||||||||||||||||||||||||||||||||| Sbjct: 155 ataccanntcaatcgataatggtgtaagtggtatttcaaaagcatgntnccttttaaatn 96 Query: 192 naattttc...anagcttctcccgacactanaggatttgcnattnnatgtggtactngggatg 251 ||||||||||||||||||||||||||

  6. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  7. Sp ectroscopy of Low-lying States in Odd-Z Odd-A Nuclei Beyond Lead

    Institute of Scientific and Technical Information of China (English)

    U Jakobsson; S Juutinen; A Herzan; J Konki; M Leino; M Mallaburn; J Pakarinen; P Papadakis; J Partanen; P Rahkila; M Sandzelius; J Uusitalo; J Saren; C Scholey; J Sorri; S Stolze; K Auranen; H Badran; B Cederwall; D M Cox; T Grahn; P T Greenlees; R Julin

    2016-01-01

    Low-lying states in odd-Z odd-mass nuclei at the proton drip-line beyond lead have recently been studied through fusion-evaporation reactions using a gas-filled recoil separator. Isomeric 1/2+ and 13/2+ states have been observed in odd-mass astatine and francium nuclei. The systematic behaviour of the level energies of these states have been studied and a similarity between the 1/2+ state in astatine and francium has been found. Furthermore, the 13/2+ state has been observed in the francium nuclei with an oblate behaviour suggesting a coupling of the i13/2 proton to the 2p−2h intruder excitation.

  8. Two-component relativistic density-functional calculations of the dimers of the halogens from bromine through element 117 using effective core potential and all-electron methods.

    Science.gov (United States)

    Mitin, Alexander V; van Wüllen, Christoph

    2006-02-14

    A two-component quasirelativistic Hamiltonian based on spin-dependent effective core potentials is used to calculate ionization energies and electron affinities of the heavy halogen atom bromine through the superheavy element 117 (eka-astatine) as well as spectroscopic constants of the homonuclear dimers of these atoms. We describe a two-component Hartree-Fock and density-functional program that treats spin-orbit coupling self-consistently within the orbital optimization procedure. A comparison with results from high-order Douglas-Kroll calculations--for the superheavy systems also with zeroth-order regular approximation and four-component Dirac results--demonstrates the validity of the pseudopotential approximation. The density-functional (but not the Hartree-Fock) results show very satisfactory agreement with theoretical coupled cluster as well as experimental data where available, such that the theoretical results can serve as an estimate for the hitherto unknown properties of astatine, element 117, and their dimers.

  9. DMPD: Heterogeneity of TLR-induced responses in dendritic cells: from innate toadaptive immunity. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available daptive immunity. Re F, Strominger JL. Immunobiology. 2004;209(1-2):191-8. (.png) (.svg) (.html) (.csml) Sho...toadaptive immunity. Authors Re F, Strominger JL. Publication Immunobiology. 2004;209(1-2):191-8. Pathway -

  10. Enhanced 1-meter Composite Grayscale Image of the Sidescan-Sonar Data From National Oceanic and Atmospheric Administration (NOAA) Survey H11079 of the Sea Floor in Great Round Shoal Channel, Offshore Massachusetts (H11079_UTM19_1MRSSS.TIF, UTM Zone 19)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The U.S. Geological Survey (USGS), in cooperation with the National Oceanic and Atmospheric Administration (NOAA) and the Massachusetts Office of Coastal Zone...

  11. Germán Giraldo. Canje para la paz. Intercambio de prisioneros de guerra en los conflictos de Colombia y Centroamérica ¿Qué lecciones nos dejan?. Bogotá: Editorial Universidad Autónoma de Colombia, 2014. 191 páginas

    Directory of Open Access Journals (Sweden)

    Juan Manuel Martínez Fonseca

    2015-07-01

    Full Text Available El libro del historiador Germán Giraldo, dedicado al tema del canje, se suma a una nueva oleada de análisis, inscrita en el contexto marcado por los diálogos paz, en La Habana, entre delegados del Gobierno y las Fuerzas Armadas de Colombia —FARC—. Aparte de la vigencia y pertinencia de la problemática abordada, se resalta el esfuerzo del autor por mantenerse en su objeto de estudio, pues dada la amplitud de la cuestión, perfectamente pudo haber terminado dando cuenta de otros procesos como la historia de las guerrillas o los diálogos de paz. Si bien el canje y las negociaciones con la insurgencia y, específicamente, con las FARC no cuentan con un buen recuerdo en el colectivo, es interesante la manera como en esta obra se busca superar el énfasis en el análisis de carácter coyuntural y local para dar paso al planteamiento de una investigación de largo alcance, que subraye la importancia de ver el intercambio de prisioneros, con un enfoque estructural y que incorpore la historia comparada.

  12. Alpha-decay studies of the new isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At

    CERN Document Server

    Kettunen, H; Grahn, T; Greenlees, P T; Jones, P; Julin, R; Juutinen, S; Keenan, A; Kuusiniemi, P; Leino, M; Leppaenen, A P; Nieminen, P; Pakarinen, J; Rahkila, P; Uusitalo, J

    2003-01-01

    Detailed alpha-decay studies have been performed for the neutron-deficient isotopes sup 1 sup 9 sup 1 At and sup 1 sup 9 sup 3 At. The nuclei were produced in fusion-evaporation reactions of sup 5 sup 4 Fe and sup 5 sup 6 Fe ions with a sup 1 sup 4 sup 1 Pr target. The fusion products were separated in-flight using a gas-filled recoil separator and implanted into a position-sensitive silicon detector. The isotopes were identified using position, time and energy correlations between the implants and subsequent alpha-decays. Three alpha-decaying states were identified for sup 1 sup 9 sup 3 At and two for sup 1 sup 9 sup 1 At. The spin and parity of the initial states in the astatine isotopes were deduced based on unhindered alpha-decays to states in the bismuth daughter nuclei. In both astatine isotopes the 1/2 sup + intruder state was determined to be the ground state and a 7/2 sup - state to be the first-excited state. In sup 1 sup 9 sup 3 At the alpha-decay of the 13/2 sup + state was observed in coincidence...

  13. Dicty_cDB: Contig-U14796-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ||||||| Sbjct: 132 agatcaaatttaaaagtgacgaaccattaatttacatgggataattaaacaaatatcagt 191 Query: 192 agtgttggattggttatttgcttccacttttgctttca...bjct: 192 agtgttggattggttatttgcttccacttttgctttcanggagctcagatatatcac 248 Score = 3...taattaaacaaatatcagt 59 Query: 192 agtgttggattggttatttgcttccacttttgctttcanggagctcagatatatcac 248 ||||||||||||...||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 58 agtgttggattggttatttgcttccacttttgctttcanggagctcagatat

  14. AcEST: DK953674 [AcEST

    Lifescience Database Archive (English)

    Full Text Available AQVEENELWNR---LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK 327 Query: 191 VEKALDSM--DEEATQFYKEERANIVEDEPSAVRDMMFEQSE...EEKIREQEEKMRRQEEMMMWE 345 Query: 182 QQEVEKALDSM--DEEATQFYKEERANIVEDEPSAVRDMMFEQSEHLER-ELEQMGEQIR 352 ++E +

  15. Interaction of the mechanism-based inactivator acetylene with ammonia monooxygenase of Nitrosomonas europaea.

    Science.gov (United States)

    Gilch, Stefan; Vogel, Manja; Lorenz, Matthias W; Meyer, Ortwin; Schmidt, Ingo

    2009-01-01

    The ammonia monooxygenase (AMO) of Nitrosomonas europaea is a metalloenzyme that catalyses the oxidation of ammonia to hydroxylamine. We have identified histidine 191 of AmoA as the binding site for the oxidized mechanism-based inactivator acetylene. Binding of acetylene changed the molecular mass of His-191 from 155.15 to 197.2 Da (+42.05), providing evidence that acetylene was oxidized to ketene (CH2CO; 42.04 Da) which binds specifically to His-191. It must be assumed that His-191 is part of the acetylene-activating site in AMO or at least directly neighbours this site.

  16. Dicty_cDB: Contig-U13305-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 8), Expect = e-157 Identities = 452/452 (100%) Strand = Plus / Plus Query: 11 attatttttcaaaacctttcan...||||||||||||| Sbjct: 11 attatttttcaaaacctttcanatttaaantgggatttatcttgggattttgcaattaan 70 Query: 71 atgttaacan...nattcaaaattntttgnactt 190 Query: 191 ttatccganacaanagntgacccaangaananaaatttcnctgaaagttcanggggngna 250 ||||||...|||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 191 ttatccganacaanagntgacccaangaananaaatttcnctgaaagttcan...0%) Strand = Plus / Minus Query: 11 attatttttcaaaacctttcanatttaaantgggatttatcttgggattttgcaattaan 70 ||||||||

  17. 40 CFR 197.4 - What standard must DOE meet?

    Science.gov (United States)

    2010-07-01

    ... Health and Environmental Standards for Storage § 197.4 What standard must DOE meet? The DOE must ensure... storage (as defined in 40 CFR 191.2) of radioactive material that: (1) Is subject to 40 CFR 191.3(a);...

  18. 10 CFR 63.204 - Preclosure standard.

    Science.gov (United States)

    2010-01-01

    ... MOUNTAIN, NEVADA Preclosure Public Health and Environmental Standards § 63.204 Preclosure standard. DOE... of 0.15 mSv (15 mrem) from the combination of: (a) Management and storage (as defined in 40 CFR 191.2) of radioactive material that: (1) Is subject to 40 CFR 191.3(a); and (2) Occurs outside of the...

  19. 49 CFR Appendix B to Part 238 - Test Methods and Performance Criteria for the Flammability and Smoke Emission Characteristics of...

    Science.gov (United States)

    2010-10-01

    ..., and Laminated Apparel Fabrics. (iii) ASTM D 3574-95, Standard Test Methods for Flexible Cellular...'Enfant Plaza, SW., Suite 8100, Washington, DC, 20407. FED-STD-191A-Textile Test Method 5830, Leaching... demonstrated to be permanent by washing, if appropriate, according to FED-STD-191A Textile Test Method 5830....

  20. 76 FR 45336 - Departmental Offices; Privacy Act of 1974, as Amended; Systems of Records

    Science.gov (United States)

    2011-07-28

    ... notice of alterations to its Privacy Act systems of records entitled ``Treasury/DO .191--Human Resources... Resources and Administrative Records system,'' follow: Treasury/DO .191 System Name: Human Resources and... information is retrieved; designation of a new system manager and address; and new record source category......

  1. Experimental and Theoretical Studies of Autoignition and Burning Speed of JP8 and DF-2

    Science.gov (United States)

    2008-10-20

    Isooctane and Indolence at High Pressure and Temperature." Combustion and Flame 48: 191-210, 1982. [3] Elia, M., Moore,P., Ulinski, M., and Metghalchi...34Burning Velocities of Mixtures of Air with Methanol, Isooctane and Indolence at High Pressure and Temperature." Combustion and Flame 48: 191-210

  2. Quartz and feldspar distribution in continental shelf sediments of east coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, V.P.; VijayKumar, B.

    stream_size 5 stream_content_type text/plain stream_name Indian_J_Mar_Sci_19_191.pdf.txt stream_source_info Indian_J_Mar_Sci_19_191.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  3. 75 FR 16786 - Environmental Impacts Statements; Notice of Availability

    Science.gov (United States)

    2010-04-02

    ... Period Ends: 04/02/2010, Contact: Deborah Darden 304-465-6509. Revision to FR Notice Published 01/29/2010... Island, VA, Comment Period Ends: 04/19/2010, Contact: Joshua A. Bundick 757-824-2319. Revision to FR... Easement--Forest Roads 191 and 191D, Implementation, Cibola National Forest, McKinley County, NM,...

  4. Helicopter Transparent Enclosures. Volume 1. Design Handbook

    Science.gov (United States)

    1979-01-01

    187 12.3 Major Parameters Influencing Spallation .... ...... 191 12.4 Impact Conditions .......... ................. 191 12.5...29.1 Machinability ...... ....... ................ 386 29.2 Drilling . . . ................. . 387 29.3 Glass...Recommended Drill Geometry for Acrylic Plastics ....... ..... ..... ..... ..... ....... 387 29-3 Poorly Drilled Hole in Stretched Acrylic ...... 38A 29-4

  5. EST Table: CN374994 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CN374994 rzhswab0_003238 10/09/28 72 %/191 aa ref|XP_970542.1| PREDICTED: similar to brix...26-PA 10/09/10 72 %/191 aa gi|91090402|ref|XP_970542.1| PREDICTED: similar to brix domain-containing protein 2 [Tribolium castaneum] FS911686 L12 ...

  6. Is electronegativity a useful descriptor for the pseudo-alkali metal NH4?

    Science.gov (United States)

    Whiteside, Alexander; Xantheas, Sotiris S; Gutowski, Maciej

    2011-11-18

    Molecular ions in the form of "pseudo-atoms" are common structural motifs in chemistry, with properties that are transferrable between different compounds. We have determined one such property--the electronegativity--for the "pseudo-alkali metal" ammonium (NH(4)), and evaluated its reliability as a descriptor versus the electronegativities of the alkali metals. The computed properties of ammonium's binary complexes with astatine and of selected borohydrides confirm the similarity of NH(4) to the alkali metal atoms, although the electronegativity of NH(4) is relatively large in comparison to its cationic radius. We have paid particular attention to the molecular properties of ammonium (angular anisotropy, geometric relaxation and reactivity), which can cause deviations from the behaviour expected of a conceptual "true alkali metal" with this electronegativity. These deviations allow for the discrimination of effects associated with the molecular nature of NH(4).

  7. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

    2013-01-01

    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  8. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: bruce.marsh@cern.ch [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others

    2013-12-15

    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  9. The Rhizobium etli rpoN Locus: DNA Sequence Analysis and Phenotypical Characterization of rpoN, ptsN, and ptsA Mutants

    OpenAIRE

    Michiels, Jan; Van Soom, Tom; D’hooghe, Inge; Dombrecht, Bruno; Benhassine, Traki; Wilde, Petra; Vanderleyden, Jos

    1998-01-01

    The rpoN region of Rhizobium etli was isolated by using the Bradyrhizobium japonicum rpoN1 gene as a probe. Nucleotide sequence analysis of a 5,600-bp DNA fragment of this region revealed the presence of four complete open reading frames (ORFs), ORF258, rpoN, ORF191, and ptsN, coding for proteins of 258, 520, 191, and 154 amino acids, respectively. The gene product of ORF258 is homologous to members of the ATP-binding cassette-type permeases. ORF191 and ptsN are homologous to conserved ORFs f...

  10. The 1991 Neural Information Processing Systems-natural & Synthetic

    Science.gov (United States)

    1993-02-01

    Genertic Algorithms Edited by Gregory J.E. Rawlins Genetic Algorithms: Proceedings of the Fourth !nwrnarwnal Conference Edited by Rick Belew and...Data ......... ..................... 191 Makoto Hrayama. Eric Vankiotii- Bateson , Mieuo Kawato. and Michael L Jordan English Alphabet Recognition with

  11. 78 FR 55056 - Notice of Petitions by Firms for Determination of Eligibility To Apply for Trade Adjustment...

    Science.gov (United States)

    2013-09-09

    .... commercial printed products. Military Truck Parts, Inc 37910 HWY. 191, Many, LA 8/30/2013 The firm is a 71449. manufacturer of specialty vehicles such as military transport and civilian first responder utility...

  12. Visit Itinerary

    CERN Multimedia

    2002-01-01

    The visit itinerary includes five area of halls 191 and 180:. End-Cap Toroid Integration Area . Barrel Toroid Integration Area . Cryogenic Test Facility for Toroid Magnets and Helium Pumps . Liquid Argon Cryostats Assembly Area . Central Solenoid Magnet Test Station

  13. 78 FR 33891 - North Central Railway Association, Inc.-Abandonment Exemption-in Franklin and Hardin Counties, Iowa

    Science.gov (United States)

    2013-06-05

    ... (Sub-No. 3X)] North Central Railway Association, Inc.--Abandonment Exemption-- in Franklin and Hardin... milepost 201.46 at or near Ackley, and milepost 191.0 at or near Geneva, in Franklin and Hardin...

  14. Interpenetrated Structure and Compressibility Studies in Pressure Frozen Pentafluoropyridine Crystals at 0.3 and 1.1 GPa (Postprint)

    Science.gov (United States)

    2008-01-01

    Ger- many, 1997. [24] L.J. Barbour, J. Supramol. Chem. 1 (2001) 189–191. [25] Persistence of Vision Pty. Ltd. Persistence of Vision (TM) Raytracer , Version 2.6. Williamstown, Victoria, Australia, 2004.

  15. Positioning of Learners in Learning Networks with Content, Metadata and Ontologies

    NARCIS (Netherlands)

    Kalz, Marco; Van Bruggen, Jan; Rusman, Ellen; Giesbers, Bas; Koper, Rob

    2006-01-01

    Kalz, M, Van Bruggen, J., Rusmann, E., Giesbers, B., & Koper, R. (2007). Positioning of Learners in Learning Networks with Content-Analysis, Metadata and Ontologies. Interactive Learning Environments, 15, 191-200.

  16. Impact of teaching session on concepts of palliative care in medical undergraduates.

    Directory of Open Access Journals (Sweden)

    Sirisha Annavarapu

    2016-02-01

    Conclusions: Concept of palliative care was poor among medical undergraduates. Health care providers can overcome by knowledge construction, interrelation between practice and evidence based medicine. [Int J Basic Clin Pharmacol 2016; 5(1.000: 188-191

  17. Dicty_cDB: Contig-U14071-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available p... 191 3e-47 NRL( 721P ) H-ras p21 protein mutant with gln 61 replaced by leu (... 191 3e-47 AY892487_1( ...191 3e-47 NRL( 621P ) H-ras p21 protein mutant with gln 61 replaced by his (... 191 3e-47 AY886901_1( AY8869...L( 221P ) H-ras p21 protein mutant with asp 38 replaced by glu (... 190 7e-47 J02207_2( J02207 |pid:none) ha...otein p29; Contains: Rec... 189 1e-46 NRL( 1AGP ) H-ras p21 protein mutant with gly 12 replaced by asp (... ...16 |pid:none) Ustilago maydis small G-protein Ra... 189 2e-46 NRL( 421P ) H-ras p21 protein mutant with gly 12 replace

  18. NMFS Scientific Publications Office: Legacy Series: Circulars

    Science.gov (United States)

    ... Research related to the case for abstention, ... The Colorado River-Matagorda Bay study, by Charles H. Koski, p. 70-74; Movement of water masses ... Circular 191. Extent of acid mine pollution ...

  19. The potential role of migratory birds in transmission cycles of Babesia spp., Anaplasma phagocytophilum, and Rickettsia spp.

    Science.gov (United States)

    Hildebrandt, Anke; Franke, Jan; Meier, Frank; Sachse, Svea; Dorn, Wolfram; Straube, Eberhard

    2010-06-01

    Babesia spp., Anaplasma phagocytophilum, and Rickettsia spp. are potentially emerging tick-borne pathogens, whereas many issues about their ecology, e.g. reservoir host specificity, are still unclear. In spring 2007, we collected 191 feeding Ixodes ricinus ticks from 99 birds of 11 different species on a German bird conservation island in the Baltic Sea. Babesia spp. were detected in 4.7% (9/191), A. phagocytophilum was present in 2.6% (5/191), and Rickettsia spp. were identified in 7.3% (14/191) of the investigated ticks. Further characterization of Babesia spp. infections resulted in B. divergens and B. microti. Among the Rickettsia spp. infections, we identified at least 2 different species: R. monacensis and R. helvetica. Furthermore, 2 ticks harboured mixed infections. Our study provides first interesting insights into the role of migratory birds in the distribution of several emerging tick-borne pathogens.

  20. Doktoritöö eesti värvinimetustest / Lembit Vaba

    Index Scriptorium Estoniae

    Vaba, Lembit

    2001-01-01

    Rets.: Oja, Vilja. Linguistic studies of Estonian colour terminology. Tartu : Tartu University Press, 2001. 191, [1] lk. : ill. (Dissertationes philologiae estonicae Universitatis Tartuensis. 1406-1325 ; 9). ISBN 9985565827

  1. Field Plot Points for Voyageurs National Park Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — A total of 191 vegetation field plot samples were collected at Voyageurs National Park and environs to support vegetation classification development. Teams of...

  2. Tsunami induced transportation of the coastal marine sediments to distant onshore regions: Some indications from foraminiferal and microbenthic studies of new Wandoor region (Andaman & Nicobar)

    Digital Repository Service at National Institute of Oceanography (India)

    Khare, N.; Chaturvedi, S.K.; Ingole, B.S.

    (Ariopsis felis) and their potential to record low latitude climate change. Paleoceanography, Paleoclimatology and Paleoecology, 28, 179-191 (2005) 2. Harris P.T., Marine geology and sedimentology of the Australian continental shelf. In: Leon P. Zann (Ed...

  3. Critical Care Statistics

    Science.gov (United States)

    ... 6%. Sources: Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates ... May 15;191(10):1147-1157. Wunsch H, Guerra C, Barnato AE, Angus DC, Li G, Linde- ...

  4. AcEST: DK949581 [AcEST

    Lifescience Database Archive (English)

    Full Text Available ISLTP ++ WKW +T+ F K P + + Sbjct: 144 PLSLNFMHSAAPITAMGQV--VDQGISLTPAIEGEWKWATER...+ P+ A+ + V+ ISLTP ++ WKW +T+ F K P + + Sbjct: 132 PLSLNFMHSAAPITAMGQV--VDQGISLTPAIEGEWKWATERTLVFTPKKAWPMGANYQI 189 Query: 630 SV 635 ++ Sbjct: 190 TI 191 ...

  5. Dicty_cDB: Contig-U14141-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tities = 257/263 (97%) Strand = Plus / Plus Query: 11 aatccnaaacctggnccccaatattatccccnancnactttnccnntatttgaa...tccccn 70 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 11 aatccna...aacctggnccccaatattatccccnancnactttnccnntatttgaatccccn 70 Query: 71 aangnttttganaaatttganatnganaccntgn...| Sbjct: 131 anttatcnacaanatcnagcagntaaannattaaanaaacaaggntggagntntnataaa 190 Query: 191 aaanatntcncctggnttanaanacatgaagnaccna...aanaaatnccnaangaatttgaa 250 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| S

  6. EST Table: CA946264 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CA946264 KI000001 10/09/28 75 %/192 aa ref|XP_001653815.1| crooked neck protein [Ae...|gene:AGAP001879 10/09/10 75 %/191 aa gnl|Amel|GB15949-PA 10/09/10 71 %/191 aa gi|91094535|ref|XP_972454.1| PREDICTED: similar to AGAP001879-PA [Tribolium castaneum] BW997846 L9 ...

  7. Processing Benefits of Resonance Acoustic Mixing on High Performance Propellants and Explosives

    Science.gov (United States)

    2012-02-01

    Initial Energetic Evaluation File: NAVAIR Brief 12 • Selected Energetics – Polymers: GAP, PGN, PNO , BN-7 – Plasticizers: BTTN, TMETN, TEGDN, BuNena...BTTN-CL20 202 204 2 PGN-BTTN-RDX 191 191 0 PGN-BTTN-HMX 183 186 3 PGN-BTTN-CL20 189 189 0 PNO -BTTN-RDX 184 189 5 PNO -BTTN-HMX 179 175 4 PNO -BTTN

  8. Dicty_cDB: Contig-U11144-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available d:none) Bactrocera tryoni scarlet gene, co... 195 8e-48 AF442747_1( AF442747 |pid:none) Tribolium castaneum ...deum ABC trans... 191 1e-46 ( P45843 ) RecName: Full=Protein scarlet; &AE014296_2908(AE014296... 191 1e-46 A...one) Drosophila melanogaster scarlet protei... 186 5e-45 AM270320_67( AM270320 |pid:none) Aspergillus niger

  9. Tent Shaped Phased Array Tests.

    Science.gov (United States)

    1982-01-01

    AD-A113 191 HARRIS CORP MELBOURNE FL GOVERNMENT COMMUNICATION SY-ETC Fi 20/11TENT SHAPED PHASED ARRAY TESTS.(U JAN 82 C A CHUANG F19628-79-C-T173...821714f1 45 0 +450 SCAN PLANE ARRAY PATTERNS FIG. B-31 B- 31 AD-AL13 191 HARRS CRP PMELBOURNE FLY GOVERNMENT COMMUNICATION ST--ETC F/6 20/14 TENT SHAPED

  10. vacA Gene Subtypes of Helicobacter pylori in Guangdong Area and their Relationships with Gastrointestinal Diseases%广东地区幽门螺杆菌vacA基因亚型及其与胃肠疾病的关系

    Institute of Scientific and Technical Information of China (English)

    何瑶; 胡品津; 何兴祥; 曾志荣; 陈为; 彭晓忠

    2000-01-01

    目的:探讨广东地区幽门螺杆菌(H.pylori)vacA基因亚型的流行情况及不同vacA亚型与H.pylori相关性胃肠疾病的关系.方法:自广东地区不同胃十二指肠疾病患者胃粘膜中分离得到191株H.pylori菌株,抽提各菌株总DNA,用特定引物对各菌株vacA基因的信号序列(s)及中间区等位基因(m)行聚合酶链反应(PCR)检测.结果:广东地区患者H.pylori的vacA亚型有s1a/m2、s1a/m1b、s1b/m2、s1a/m1b-m2、s1b/m1b和s2/m2 6种组合,各亚型所占的比例分别为88.0%(168/191)、7.3%(14/191)、3.1%(6/191)、0.5%(1/191)、0.5%(1/191)和0.5%(1/191).vacA各亚型在不同H.pylori相关性胃十二指肠疾病中的检出率无显著差异.结论:广东地区H.pylori的vacA基因亚型绝大多数为s1a/m2型.不能单纯以vacA亚型作为预测H.pylori感染后临床结局的指标.

  11. An N-terminal three-helix fragment of the exchangeable insect apolipoprotein apolipophorin III conserves the lipid binding properties of wild-type protein.

    Science.gov (United States)

    Dettloff, M; Weers, P M; Niere, M; Kay, C M; Ryan, R O; Wiesner, A

    2001-03-13

    Apolipophorin III (apoLp-III) from the greater wax moth Galleria mellonella is an exchangeable insect apolipoprotein that consists of five amphipathic alpha-helices, sharing high sequence identity with apoLp-III from the sphinx moth Manduca sexta whose structure is available. To define the minimal requirement for apoLp-III structural stability and function, a C-terminal truncated apoLp-III encompassing residues 1-91 of this 163 amino acid protein was designed. Far-UV circular dichroism spectroscopy revealed apoLp-III(1-91) has 50% alpha-helix secondary structure content in buffer (wild-type apoLp-III 86%), increasing to essentially 100% upon interactions with dimyristoylphosphatidylcholine (DMPC). Guanidine hydrochloride denaturation studies revealed similar stability properties for wild-type apoLp-III and apoLp-III(1-91). Resistance to denaturation for both proteins increased substantially upon association with phospholipid. In the absence of lipid, wild-type apoLp-III was monomeric whereas apoLp-III(1-91) partly formed dimers and trimers. Discoidal apoLp-III(1-91)-DMPC complexes were smaller in diameter (13.5 nm) compared to wild-type apoLp-III (17.7 nm), and more molecules of apoLp-III(1-91) associated with the complexes. Lipid interaction revealed that apoLp-III(1-91) binds to modified spherical lipoprotein surfaces and efficiently transforms phospholipid vesicles into discoidal complexes. Thus, the first three helices of G. mellonella apoLp-III contain the basic features required for maintenance of the structural integrity of the entire protein.

  12. Development of Reagents for Application of At-211 to Targeted Radionuclide Therapy of Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D. Scott

    2011-12-23

    This grant covered only a period of 4 months as the major portion of the award was returned to DOE due to an award of funding from NIH that covered the same research objectives. A letter regarding the termination of the research is attached as the last page of the Final Report. The research conducted was limited due to the short period of this grant, but the results obtained in that period are outlined in the Final Report. The studies addressed in the research effort were directed at a problem that is of critical importance to the in vivo application of the alpha-particle emitting radionuclide At-211. That problem, low in vivo stability of many astatinated molecules, severely limits the use of At-211 in therapeutic applications. The advances sought in the studies were expected to expand the types of biomolecules that can be used as carriers of At-211, and provide improved in vivo targeting of the radiation dose compared with the dose delivered to normal tissue.

  13. Combined effect of gefitinib ('Iressa', ZD1839) and targeted radiotherapy with {sup 211}At-EGF

    Energy Technology Data Exchange (ETDEWEB)

    Sundberg, Aasa Liljegren; Orlova, Anna; Gedda, Lars; Tolmachev, Vladimir; Carlsson, Joergen [Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala (Sweden); Almqvist, Ylva [Division of Radiology, Uppsala University, Uppsala (Sweden); Blomquist, Erik [Division of Oncology, Uppsala University, Uppsala (Sweden); Jensen, Holger J. [Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Rigshospitalet, Copenhagen (Denmark)

    2003-10-01

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib ['Iressa' (trademark of the AstraZeneca group of companies), ZD1839] increases the cellular uptake of radiolabelled epidermal growth factor (EGF). We investigated gefitinib treatment combined with astatine-211 EGF targeting in vitro using two cell lines expressing high levels of EGFR: A431 (sensitive to gefitinib) and U343MGaCl2:1 (resistant to gefitinib). In both cell lines, the uptake of {sup 211}At-EGF was markedly increased by concomitant treatment with gefitinib. Survival was investigated using both a clonogenic survival assay and a cell growth assay. Combined gefitinib and {sup 211}At-EGF treatment reduced the survival of U343 cells 3.5-fold compared with {sup 211}At-EGF alone. In A431 cells, {sup 211}At-EGF treatment resulted in very low survival, but combined treatment with gefitinib increased the survival by about 20-fold. These results indicate that combined treatment with gefitinib might increase the effect of ligand-mediated radionuclide therapy in gefitinib-resistant tumours and decrease the effect of such therapy in gefitinib-sensitive tumours. (orig.)

  14. Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Nestor, Marika, E-mail: marika.nestor@bms.uu.s [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden); Sundstroem, Magnus [Unit of Molecular Pathology, Department of Genetics and Pathology, Uppsala University (Sweden); Anniko, Matti [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Tolmachev, Vladimir [Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden)

    2011-01-15

    Aim: The monoclonal antibody cetuximab, targeting the epidermal growth factor receptor (EGFR), is a promising molecular targeting agent to be used in combination with radiation for anticancer therapy. In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed. Methods: SCC cell lines were characterized and treated with cetuximab in combination with anti-CD44v6 RIT using the astatinated chimeric monoclonal antibody U36 ({sup 211}At-cMAb U36). Effects on {sup 211}At-cMAb U36 uptake, internalization and cell proliferation were then assessed in SCC cells. Results: Cetuximab in combination with {sup 211}At-cMAb U36 mediated increased growth inhibition compared to RIT or cetuximab alone in two cell lines. However, cetuximab also mediated radioprotective effects compared to RIT alone in two cell lines. The radioprotective effects occurred in the cell lines in which cetuximab clearly inhibited cell growth during radiation exposure. Cetuximab treatment also influenced {sup 211}At-cMAb-U36 uptake and internalization, suggesting interactions between CD44v6 and EGFR. Conclusions: Results from this study demonstrate the vast importance of further clarifying the mechanisms of cetuximab and radiation response, and the relationship between EGFR and suitable RIT targets. This is important not only in order to avoid potential radioprotective effects, but also in order to find and utilize potential synergistic effects from these combinations.

  15. Cyclotron production of cesium radionuclides as analogues for francium-221 biodistribution

    Science.gov (United States)

    Finn, R.; McDevitt, M.; Sheh, Y.; Lom, C.; Qiao, J.; Cai, S.; Burnazi, E.; Nacca, A.; Pillarsetty, N.; Jaggi, J.; Scheinberg, D.

    2005-12-01

    In our clinical investigations focussing on improved therapeutic treatment of specific tumors we have concentrated on a targeted therapy approach utilizing designed radiolabeled monoclonal antibodies as the cytotoxic reagent. The physical characteristics of the alpha particle emitting radionuclide bismuth-213 including the short half-life of 45.6 min, has shown promise for the treatment of specific cancers such as leukemias and lymphomas or micrometastatic carcinomas. In an effort to increase the cytocidal effect of the HuM195, a humanized monoclonal antibody carrier to the CD33 antigen expressed on leukemia cells, our focus is directed toward an "internal" nano-generator composed of Ac-225 radionuclide, the parent of the bismuth-213. The actinium-225 radionuclide decays through several short-lived, alpha emitting daughters including francium-221, astatine-217 and bismuth-213. In order to study the biodistribution and the pharmacokinetics of the individual daughter nuclide, francium-221, the cyclotron production and separation of cesium radionuclides, specifically cesium-132, from a natural xenon gas target was undertaken. The choice of cesium as an analogue for francium was predicated upon both elements being in Group 1A alkali metals and cesium radionuclide possesses a sufficient half-life to allow biodistribution studies to be performed. The preliminary experimental results of this investigation are presented.

  16. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  17. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  18. Metalloids, soil chemistry and the environment.

    Science.gov (United States)

    Lombi, Enzo; Holm, Peter E

    2010-01-01

    This chapter reviews physical chemical properties, origin and use ofmetalloids and their relevance in the environment. The elements boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), tellurium (Te), polonium (Po) and astatine (At) are considered metalloids. Metalloids conduct heat and electricity intermediate between nonmetals and metals and they generally form oxides. The natural abundance ofmetalloids varies from Si being the second most common element in the Earth's crust to At as the rarest of natural elements on Earth. The metalloid elements Ge, Te, Po and At are normally present in trace or ultratrace levels in the environment and as such are not considered of relevance in terms of environmental health. The environmental geochemical processes, factors and parameters controlling the partitioning and the speciation of B, Si, As and Sb are reviewed in relation to the bioavailability of these metalloids. Approaches based on the hypothesis that metal toxicity is related to both the metal-ligand complexation processes and the metal interactions with competing cations at the cell surface (biotic ligand) have so far not been successful for assessing metalloid bioavailability. The chapter concludes that our understanding of metalloids toxicity will improve in the future if, in addition to the points discussed above, surface membrane potentials are considered. This should represent a robust approach to the prediction of metalloid toxicity.

  19. SPECT assay of radiolabeled monoclonal antibodies. Progress report, September 1, 1992--August 24, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1993-08-20

    The overall goal of this project is to improve the effectiveness of single photon emission computed tomography (SPECT) to image and quantify radiolabeled monoclonal antibodies. During the past year, we have made significant progress toward this goal, and this report summarizes that work. Our efforts have been mainly directed along three fronts. First, we have developed and tested new reconstruction methods including three-dimensional iterative algorithms that model non-uniform attenuation and distance-dependent detector response. Both fan beam and parallel beam collimator geometries have been modeled and novel ways of improving the efficiency of the computationally intensive methods have been introduced. Second, an ultra-high resolution, small field-of-view pinhole collimator has been constructed and evaluated. Reconstructed spatial resolution of 1 to 3 mm (FWHM) has been achieved in phantom scans with a useful field-of-view of 9 to 10 cm. Finally, we have investigated the ability of SPECT to image and quantify astatine-211 distributions. Reconstructed images of phantom data demonstrated quantitative accuracy to within 10% with proper attenuation and scatter compensation.

  20. Glomerular filtration rate after alpha-radioimmunotherapy with 211At-MX35-F(ab')2: a long-term study of renal function in nude mice

    DEFF Research Database (Denmark)

    Back, T.; Haraldsson, B.; Hultborn, R;

    2009-01-01

    and animals bearing subcutaneous xenografts of the human ovarian cancer cell line, OVCAR-3, were used. The animals received approximately 0.4, 0.8, or 1.2 MBq in one, two, or three fractions. The mean absorbed doses to the kidneys ranged from 1.5 to 15 Gy. The renal function was studied by serial GFR...... of the glomerular filtration rate (GFR). The renal toxicity was evaluated at levels close to the dose limit for the bone marrow and well within the range for therapeutic efficacy on tumors. Astatinated MX35-F(ab')(2) monoclonal antibodies were administered intravenously to nude mice. Both non-tumor-bearing animals...... manifested late. Examination of the kidney sections showed histologic changes that were overall subdued. Following alpha-RIT with (211)At-MX35-F(ab')(2) at levels close to the dose limit of severe myelotoxicity, the effects found on renal function were relatively small, with only minor to moderate reductions...

  1. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  2. Studies of Stable Octupole Deformations in the Radium Region

    CERN Multimedia

    2002-01-01

    The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

  3. Alpha particle emitters in medicine

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, D.R.

    1989-09-01

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ({sup 211}At) and natural bismuth-212 ({sup 212}Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ({sup 223}Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs.

  4. Probing interaction of a fluorescent ligand with HIV TAR RNA

    Science.gov (United States)

    Qi, Liang; Zhang, Jing; He, Tian; Huo, Yuan; Zhang, Zhi-Qi

    2017-02-01

    Trans-activator of Transcription (Tat) antagonists could block the interaction between Tat protein and its target, trans-activation responsive region (TAR) RNA, to inhibit Tat function and prevent human immunodeficiency virus type 1 (HIV-1) replication. For the first time, a small fluorescence ligand, ICR 191, was found to interact with TAR RNA at the Tat binding site and compete with Tat. It was also observed that the fluorescence of ICR 191 could be quenched when binding to TAR RNA and recovered when discharged via competition with Tat peptide or a well-known Tat inhibitor, neomycin B. The binding parameters of ICR 191 to TAR RNA were determined through theoretical calculations. Mass spectrometry, circular dichroism and molecular docking were used to further confirm the interaction of ICR 191 with TAR RNA. Inspired by these discoveries, a primary fluorescence model for the discovery of Tat antagonists was built using ICR 191 as a fluorescence indicator and the feasibility of this model was evaluated. This ligand-RNA interaction could provide a new strategy for research aimed at discovering Tat antagonists.

  5. 补肝肾增发灵粉剂胶囊治疗肝肾不足型脱发的临床疗效观察%Clinical observation on treating alopecia with the Zengfa Ling capsule

    Institute of Scientific and Technical Information of China (English)

    陈本善

    2014-01-01

    To investigate clinical effects of Zengfa Ling capsule on alopecia. Methods:191 patients were given Zengfa Ling capsule for 3 months. Results:188 patients were better, while 3 patients were invalid. Conclusion:Zengfa Ling shows great effects on alopecia.%目的:通过临床实践交流补肝肾增发灵粉剂胶囊治疗肝肾不足型脱发的临床治疗效果。方法:选取191例肝肾不足型脱发患者服用补肝肾增发灵粉剂胶囊治疗3个月。结果:治疗观察191例患者,188例有治疗效果,3例无效。结论:增发丸治疗脱发临床效果显著。

  6. Technical challenges of heavy wall HFW pipe production for Bord Gais Eireann pipeline project

    Energy Technology Data Exchange (ETDEWEB)

    O' Dwyer, Paul [Transmission Design Manager, Cork, (Ireland); Boothbym, Peter [MACAW Engineering Ltd., Newcastle, (United Kingdom); Tazedakis, Athanasios [Corinth Pipeworks S.A, Viotia, (Greece)

    2010-07-01

    This paper deals with the pipeline recently constructed by Bord Gais Eireann near the city of Cork in The Irish Republic. The 47.5 km pipeline comprises over 30 km of 9.5 mm and 17 km of 19.1 mm wall thickness for an outside diameter of 610 mm. This paper presents the global engineering approach adopted for the project and describes more in detail the specificities of the project and the challenges faced during production. One of the difficulties encountered was to manufacture a high strength pipeline of 19.1 mm wall thickness for HFW produced pipeline. The chemical composition of the 19.1 mm coil strip had also required new developments to accommodate the demanding drop weight tear test toughness requirement. Several methods were applied to mitigate potential risks such as increase of initial production test frequency, close monitoring during pipe production, identification of potential construction issues and the weldability performance were also tested.

  7. Regions within the N-terminal domain of human topoisomerase I exert important functions during strand rotation and DNA binding

    DEFF Research Database (Denmark)

    Hougaard, Rikke Frølich; Andersen, Félicie Faucon; Westergaard, Ole;

    2004-01-01

    amino acid residues 1–202 or 191–206 or having tryptophane-205 substituted by glycine in a broad variety of in vitro activity assays. As a result of these investigations we find that mutants altered in the region 191–206 distinguished themselves from the wild-type enzyme by a faster strand rotation step......, insensitivity towards the anti-cancer drug camptothecin in relaxation and the inability to ligate blunt end DNA fragments. The mutant lacking amino acid residues 1–202 was impaired in blunt end DNA ligation and showed wild-type sensitivity towards camptothecin in relaxation. Taken together, the presented data...... support a model according to which tryptophane-205 and possibly other residues located between position 191–206 coordinates the restriction of free strand rotation during the topoisomerization step of catalysis. Moreover, tryptophane-205 appears important for the function of the bulk part of the N...

  8. Isolation and characterization of bacteria with antibacterial properties from Nile tilapia (Oreochromis niloticus).

    Science.gov (United States)

    Etyemez, Miray; Balcazar, Jose Luis

    2016-04-01

    One hundred and twenty bacterial isolates were obtained from the intestinal mucus of Nile tilapia (Oreochromis niloticus) and screened for antagonistic activity and adherence abilities. Based on in vitro antagonism against two pathogens (Streptococcus iniae and Edwardsiella piscicida), five isolates were selected and identified by 16S rRNA gene sequence analysis. All antagonistic isolates were affiliated to the genus Bacillus, which showed inhibitory activity against S. iniae. Only the isolate B191 (closely related to Bacillus mojavensis) inhibited the growth of both pathogens. Moreover, isolate B191 adhered significantly better to fish intestinal mucus than other antagonistic isolates. According to our results, these bacterial isolates, particularly isolate B191, should be further studied to explore their probiotic effects under in vivo conditions.

  9. The role of aspartate-235 in the binding of cations to an artificial cavity at the radical site of cytochrome c peroxidase.

    Science.gov (United States)

    Fitzgerald, M M; Trester, M L; Jensen, G M; McRee, D E; Goodin, D B

    1995-09-01

    The activated state of cytochrome c peroxidase, compound ES, contains a cation radical on the Trp-191 side chain. We recently reported that replacing this tryptophan with glycine creates a buried cavity at the active site that contains ordered solvent and that will specifically bind substituted imidazoles in their protonated cationic forms (Fitzgerald MM, Churchill MJ, McRee DE, Goodin DB, 1994, Biochemistry 33:3807-3818). Proposals that a nearby carboxylate, Asp-235, and competing monovalent cations should modulate the affinity of the W191G cavity for ligand binding are addressed in this study. Competitive binding titrations of the imidazolium ion to W191G as a function of [K+] show that potassium competes weakly with the binding of imidazoles. The dissociation constant observed for potassium binding (18 mM) is more than 3,000-fold higher than that for 1,2-dimethylimidazole (5.5 microM) in the absence of competing cations. Significantly, the W191G-D235N double mutant shows no evidence for binding imidazoles in their cationic or neutral forms, even though the structure of the cavity remains largely unperturbed by replacement of the carboxylate. Refined crystallographic B-values of solvent positions indicate that the weakly bound potassium in W191G is significantly depopulated in the double mutant. These results demonstrate that the buried negative charge of Asp-235 is an essential feature of the cation binding determinant and indicate that this carboxylate plays a critical role in stabilizing the formation of the Trp-191 radical cation.

  10. Mapping the residues of protein kinase CK2 implicated in substrate recognition

    DEFF Research Database (Denmark)

    Sarno, S; Boldyreff, B; Marin, O

    1995-01-01

    , hampering the calculation of kinetic parameters. In contrast 3 mutants (K74-77A, K79R80K83A and R191,195K198A) phosphorylated the peptide with reduced efficiency accounted for by increased Km and decreased Vmax values. By using derivatives of the RRRADDSDDDDD peptide in which individual aspartyl residues...... were variably replaced by alanine(s) and two peptide substrates derived from I-2 (KYRIREQESSGEEDSDL and RRKDLHDDEEDEEMSETADGE) it was shown that mutations in the 191-198, 74-77 and 79-83 regions were the least detrimental whenever the acidic determinants were lacking at positions +1, +4/+5 and +3...

  11. Proceedings of the Symposium on the Role of Behavioral Science in Physical Security (5th Annual) Held at Gaithersburg, Maryland, June 11-12, 1980

    Science.gov (United States)

    1981-06-01

    U.S.A.) 69 1494-8. 7. Menvese, A., Dodd, G., and Poynter, A. (1977). Biochem. Soc. Trans. 5, 191-194. 73 8. Cagan, R. H., and Krueger, J. M. (1976...personnel infor- mation about a failure and allows maintenance per- Sixteen LCPs and modems in the DCC are pro- sonnet to reconfigure peripheral...Angeles Neurological Society, 1969, 34, 73 -105, 135-162, 191-220. Brenner, D., Williamson, S. F., & Kaufman, L. Visually evoked magnetic fields of the

  12. Drug: D00579 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00579 Drug Foscarnet sodium (USAN/INN); Foscavir (TN) CO5P. 3Na 191.9176 191.9508 ...d derivatives J05AD01 Foscarnet D00579 Foscarnet sodium (USAN/INN) USP drug classification [BR:br08302] Anti...virals Anti-cytomegalovirus (CMV) Agents Foscarnet D00579 Foscarnet sodium (USAN/INN) Antiherpetic Agents Foscarnet D00579 Foscar... Anti-CMV agent DNA polymerase inhibitor Phosphonic acid derivatives Foscarnet [ATC:J05AD01] D00579 Foscarne...05 ANTIVIRALS FOR SYSTEMIC USE J05A DIRECT ACTING ANTIVIRALS J05AD Phosphonic aci

  13. Mr. Ansar Shamsi, Member Finance, Mr. Malik Adalat Khan, Director Finance, Pakistan Atomic Energy Commission

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    Photo 01: Mr Ansar Shamsi, Member Finance, Pakistan Atomic Energy Commission (centre), visiting the ATLAS Tile Calorimeter in building 191 with, from left to right, Mr Syed Shaukat Hussain, Pakistan Mission in Geneva and Dr Peter Jenni, ATLAS Spokesperson. Photo 02: Mr Ansar Shamsi, Member Finance, Pakistan Atomic Energy Commission (2nd form left), visiting the ATLAS Tile Calorimeter in building 191 with, from left to right, Mr Syed Shaukat Hussain, Pakistan Mission in Geneva; Dr Peter Jenni, ATLAS Spokesperson; Dr David Jacobs and Dr Philip Bryant, Joint Pakistan-CERN Committee.

  14. Dicty_cDB: CHG749 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ngth of query: 191 length of database: 80,480,566 effective HSP length: 17 effective... length of query: 174 effective length of database: 78,821,179 effective search space: 13714885146 effective...6986 Number of sequences better than 10.0: 0 length of query: 191 length of database: Z,915,520,312 effective HSP length: 22 effectiv...e length of query: 169 effective length of database: Z,063,426,916 effective... search space: 7108719148804 effective search space used: 7108719148804 T: 0 A: 0 X1: 6

  15. Low-Temperature Additive Performance in Jet A Fuels

    Science.gov (United States)

    2013-04-01

    20% recovered, °C 189 189 189 191 191 190 50% recovered, °C 211 211 211 210 210 211 90% recovered, °C 250 249 250 240 241 242 EP , °C ≤300 267...chain n-alkanes) which are known to increase the bulk viscosity and nucleate fuel solidification as the temperature is reduced. However, the LT...studies with the LT additive. The LT additive clearly prevented the viscosity transition of the bulk fuel. However, following nucleation and growth

  16. Problems Related to Use of Some Terms in System Reliability Analysis

    Directory of Open Access Journals (Sweden)

    Nadezda Hanusova

    2004-01-01

    Full Text Available The paper deals with problems of using dependability terms, defined in actual standard STN IEC 50 (191: International electrotechnical dictionary, chap. 191: Dependability and quality of service (1993, in a technical systems dependability analysis. The goal of the paper is to find a relation between terms introduced in the mentioned standard and used in the technical systems dependability analysis and rules and practices used in a system analysis of the system theory. Description of a part of the system life cycle related to reliability is used as a starting point. The part of a system life cycle is described by the state diagram and reliability relevant therms are assigned.

  17. Million Degree Plasmas in Extreme Ultraviolet (EUV) Astrophysics. White Paper in Response to Astro2010 Science Call

    Science.gov (United States)

    2010-01-01

    ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Naval Research ...which has made two successful sounding rocket flights, during which spectra were obtained for the WDs G191- B2B (Fig. 1) and Feige 24. These were...results for G191- B2B .1-2 Analysis of the Feige 24 data is proceeding. Future opportunities are compelling; here we assume a SMEX (sec. V). We call out

  18. Sensitive detection of nucleic acids by PNA hybridization directed co-localization of fluorescent beads

    DEFF Research Database (Denmark)

    Shiraishi, Takehiko; Deborggraeve, Stijn; Büscher, Philippe;

    2011-01-01

    We have designed a pair of biotinylated peptide nucleic acid (PNA) probes targeting two sequences in 18S rRNA (from the parasite Trypanosoma brucei) at a distance of 191 nt (corresponding to maximum distance of ca. 60 nm) from each other. The PNA probes were individually bound to (strept)avidin-c......We have designed a pair of biotinylated peptide nucleic acid (PNA) probes targeting two sequences in 18S rRNA (from the parasite Trypanosoma brucei) at a distance of 191 nt (corresponding to maximum distance of ca. 60 nm) from each other. The PNA probes were individually bound to (strept...

  19. 75 FR 52932 - Notice of Commission Meeting and Public Hearing

    Science.gov (United States)

    2010-08-30

    ... hydraulic design of 0.229 mgd to 1.0 mgd. Treated wastewater will continue to discharge to Pine Creek at...-191 CP-4. An application for renewal of the Abington Township Wastewater Treatment Plant (WWTP). The existing WWTP will continue to discharge treated effluent at an annual average flow of 3.91 million...

  20. An introduction to the mechanics of performance assessment using examples of calculations done for the Waste Isolation Pilot Plant between 1990 and 1992. Revision

    Energy Technology Data Exchange (ETDEWEB)

    Rechard, R.P.

    1996-06-01

    This document provides an overview of the processes used to access the performance of the Waste Isolation Pilot Plant (WIPP). The quantitative metrics used in the performance-assessment (PA) process are those put forward in the Environmental Protection Agency`s Environmental Standards for the Management and Disposal of Spent Nuclear Fuel, HIgh-LEvel and transuranic radioactive Wastes (40 CFR 191).

  1. Dicty_cDB: CFH577 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Intestinal Lymphocyte Gallus gallus cDNA clone 1GAL_17H10 5', mRNA sequence. 42 3e-05 3 BG711333 | ( S74728 ) antiquitin=26g turgor... 191 4e-47 AY883858_1( AY883858 |pid:none) Sterkiella histriomuscorum turgor ... 190 7e-47 AY847462_1( AY847

  2. Domain Modeling: NP_001036146.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001036146.1 chr1 The structure of collagen type I. Single type I collagen molecu...le: rigid refinment c1ygvb_ chr1/NP_001036146.1/NP_001036146.1_holo_191-1185.pdb psi-blast 192E,193V,194P,19

  3. Das IPR der Verbraucherverbandsklage / Peter Rott

    Index Scriptorium Estoniae

    Rott, Peter

    2016-01-01

    Euroopa Kohtu kohtuasjast VKI v. Amazon (C‑191/15), mis puudutab lepinguliste ja lepinguväliste võlasuhete suhtes kohaldatavat õigust, tarbijaga elektroonilise kaubanduse teel sõlmitud lepingute kohaldamist ja isikuandmete töötlemist, mida teostab elektroonilise kaubanduse ettevõtja

  4. 77 FR 58590 - Determining Technical Adequacy of Probabilistic Risk Assessment for Risk-Informed License...

    Science.gov (United States)

    2012-09-21

    ... COMMISSION Determining Technical Adequacy of Probabilistic Risk Assessment for Risk-Informed License... NUREG-0800, ``Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants: LWR Edition,'' Section 19.1, ``Determining the Technical Adequacy of Probabilistic Risk Assessment...

  5. An early fragment of Constantine the African's Viaticum in Beneventan Script

    NARCIS (Netherlands)

    Irving, A J M; Long, Brian

    2016-01-01

    A brief codicological and palaeographical description of a fragment of Constantine the African's Viaticum preserved in Orleans, Mediatheque municipale, Ms. 301 (pp. 176-191). The description of the Beneventan script of the fragment reveals the importance of the manuscript for the manuscript traditio

  6. Helping Peers Seek Professional Treatment for Depression among Young South Koreans: An Application of the Theory of Planned Behavior

    Science.gov (United States)

    Lee, Sun Hae; Choi, Jung Ah; Park, Ji Hye

    2015-01-01

    This study examined the applicability of the theory of planned behavior to understand factors that influence whether young South Koreans help peers with depression to seek professional counseling services. The structural equation modeling on the survey data collected from 191 South Korean students suggests that subjective norms and behavioral…

  7. Discovery and characterization of the major late blight resistance complex in potato: genomic structure, functional diversity, and implications

    NARCIS (Netherlands)

    Huang, S.

    2005-01-01

    Potato is the most important non-cereal crop in the world. Late blight, caused by the oomycete pathogen Phytophthora infestans, is the most devastating disease of potato. In the mid-191h century, P. infestans attacked the European potato fields and this resulted in a widespread famine in Ireland. La

  8. Jealousy in response to online and offline infidelity : the role of sex and sexual orientation

    NARCIS (Netherlands)

    Dijkstra, Pieternel; Barelds, Dick P. H.; Groothof, Hinke A. K.

    2013-01-01

    The goal of the present study was to examine the emotional content and intensity of jealousy in response to different types of infidelity (both online and offline unfaithful partner behaviors) among Dutch heterosexuals (n=191) and homosexuals (n=121). Based on previous research (Dijkstra, Barelds &

  9. Lonely Parents: Observations by Public Health Nurses of Alienation in Child Abuse.

    Science.gov (United States)

    Young, Marjorie

    Public health nurses (n=191) were queried regarding their observations of alienation in families who abuse their children. Comparison was made of social isolation and powerlessness in abusive families and a control group of non-abusive families, through the Internal-External Locus of Control Scale and FIRO-B, with significant differences noted in…

  10. AcEST: BP911533 [AcEST

    Lifescience Database Archive (English)

    Full Text Available HUMAN cDNA FLJ35079 fis, clone PLACE6005283, hi... 33 7.1 tr|Q7ZZ40|Q7ZZ40_DANRE Novel protein similar to human autism...6 +P+V VS Sbjct: 191 VPKSPSVDKYNVS 203 >tr|Q7ZZ40|Q7ZZ40_DANRE Novel protein similar to human autism-related

  11. Renal failure

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009221 Nephroprotective effects of subcapsular transplantation of metanephric mesenchymal cells on acute tubular necrosis rats.CHEN DAN(陈丹),et al.Div of Pediatr Nephrol,Dept Pediatr,2nd Xiangya Hosp Central South Univ,Changsha 410011,Chin J Nephrol,2009;25(3):191-197.

  12. AcEST: BP913379 [AcEST

    Lifescience Database Archive (English)

    Full Text Available dali... 30 6.5 sp|Q24292|DS_DROME Protein dachsous OS=Drosophila melanogaster G... 30 8.5 sp|O77473|GST1B_AN...LKKQGVDKL 190 Query: 49 ------WFASM 35 WFA++ Sbjct: 191 RQKLDDWFAAI 201 >sp|Q24292|DS_DROME Protein dachsous

  13. Lexical Development in Korean: Vocabulary Size, Lexical Composition, and Late Talking

    Science.gov (United States)

    Rescorla, Leslie; Lee, Youn Mi Cathy; Oh, Kyung Ja; Kim, Young Ah

    2013-01-01

    Purpose: In this study, the authors aimed to compare vocabulary size, lexical composition, and late talking in large samples of Korean and U.S. children ages 18-35 months. Method: Data for 2,191 Korean children (211 children recruited "offline" through preschools, and 1,980 recruited "online" via the Internet) and 274 U.S.…

  14. InterPro search result: AK121167 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK121167 J023080K05 IPR010990 Transcription factors TFIIS, elongin A, CRSP70, conse...rved superfamily SSF47676 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 T116-191 3.7e-17 ...

  15. Wound Healing Studies.

    Science.gov (United States)

    1986-11-15

    strengths of the formalin- .40 fixed strips were similar in all lroupssupportinq the view that the action of B-NADH in potentiating the effect of the lysyl...Lewis, R.J., Quimby, W.C., Arch. Surg. 110:191 (1975)), that is, blood loss seems to be greater than when the carbondioxide laser is used and risks

  16. 75 FR 14500 - National Organic Program, Sunset Review (2012)

    Science.gov (United States)

    2010-03-26

    ... Sec. 205.606: Casings, from processed intestines; Celery powder; Chia (Salvia hispanica L.); Dillweed.... (191) Chia (Salvia hispanica L.). Colors derived from agricultural products-- (192) Annatto extract... hispanica L.); Dillweed oil (CAS 8006-75-5); Fish oil (Fatty acid CAS 's: 10417- 94-4, and...

  17. 46 CFR 160.005-1 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ..., Vinyl Chloride. (2) Federal Standards: No. 191—Textile Test Methods. No. 751A—Stitches, Seams, and Stitchings. (3) Military Specification: MIL-W-530F—Webbing, Textiles, Cotton, General Purpose, Natural and in... Guard. The Federal specifications and standards may be purchased from the Business Service...

  18. 46 CFR 160.002-1 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ... reference to the following documents: (1) Military Specifications: MIL-W-530—Webbing, Textile, Cotton... Chloride. (3) Federal Standards: No. 191—Textile Test Methods. No. 751A—Stitches, Seams, and Stitchings. (4.... The Federal specifications and standards may be purchased from the Business Service Center,...

  19. 46 CFR 160.052-1 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ... makes reference to the following documents. (1) (2) Military specification: MIL-W-530F—Webbing, Textile, Cotton, General Purpose, Natural and in Colors. (3) Federal Standards: No. 191—Textile Test Methods. No... and Standards may be purchased from the Business Service Center, General Services...

  20. 46 CFR 160.047-1 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ... Chloride. (2) Military specifications: MIL-W-530—Webbing, Textile, Cotton, General Purpose, Natural or in Colors. MIL-B-2766—Batt, Fibrous Glass, Lifesaving Equipment. (3) Federal Standards: No. 191—Textile Test... laboratory listed in § 160.047-6b. (2) The Federal Specifications and Standard may be purchased from...

  1. Adapted J6/JFH1-based hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon and a putative NS4A inhibitor

    DEFF Research Database (Denmark)

    Gottwein, Judith M; Jensen, Sanne B; Serre, Stéphanie B N;

    2013-01-01

    ), boceprevir (Sch503034), simeprevir (TMC435350), danoprevir (ITMN-191), and vaniprevir (MK-7009), to alpha interferon 2b, and to the putative NS4A inhibitor ACH-806. The efficacy of ACH-806 was lower than that of protease inhibitors and was not influenced by changes at amino acids 1042 and 1065 (in the NS3...

  2. Dicty_cDB: Contig-U05826-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 68 1e-20 3 ( DY810234 ) CTOX18851.b1_E09.ab1 CTO(XYZ) dandelion Taraxacum... 58 4e-20 4 ( DY810534 ) CTOX191...76.b1_P18.ab1 CTO(XYZ) dandelion Taraxacum... 58 4e-20 4 ( EG553644 ) to00660 Tom

  3. Human rhinovirus infections in symptomatic and asymptomatic subjects

    Directory of Open Access Journals (Sweden)

    C.N. Camargo

    2012-12-01

    Full Text Available The role of rhinovirus asymptomatic infections in the transmission among close contacts subjects is unknown. We tested health care workers, a pair of one child and a family member and immunocompromised patients (n =191. HRV were detected on 22.9% symptomatic and 3.6% asymptomatic cases suggesting lower transmission among contacts.

  4. The Contribution of Family Communication Patterns to Children's Interpretations of Television Violence.

    Science.gov (United States)

    Krcmar, Marina

    1998-01-01

    A study of 191 K-6 children who viewed three violent TV clips showing identical acts of aggression but with different motivations and punishments found that children rated higher in communications were more likely to see motivated violence as more justified, while children higher in control were likely to see punished violence as less justified.…

  5. Global prevalence of diabetes: estimates for 2000 and projections for 2030

    DEFF Research Database (Denmark)

    Wild, Sarah; Roglic, Gojka; Green, Anders

    2004-01-01

    OBJECTIVE — The goal of this study was to estimate the prevalence of diabetes and the number of people of all ages with diabetes for years 2000 and 2030. RESEARCH DESIGN AND METHODS — Data on diabetes prevalence by age and sex from a limited number of countries were extrapolated to all 191 World ...

  6. Software Merge: Semantics of Combining Changes to Programs

    Science.gov (United States)

    1994-01-01

    Maclane and G. Birkhoff, Algebra, Macmillan, New York, 1967.._ 18. J. McKinsey and A. Tarski, "The Algebra of Topology", Annals of Mathematics 45, 1 (Jan...1944), 14-1-191. 28 19. J. McKinsey and A. Tarski, "On Closed Elements in Closure Alggebras", Annals of Mathematics 47, 1 (Jan. 1946), 122 - 162. 20

  7. Modal Logics and Topological Semantics for Hybrid Systems

    Science.gov (United States)

    1997-06-01

    Propositional S4 in Cantor Space", manuscript, August 1995. [MT44] J. C. C. McKinsey and Alfred Tarski, "The Algebra of Topology", Annals of Mathematics 45...1944) 141-191. [MT46] J. C. C. McKinsey and Alfred Tarski, "On Closed Elements in Closure Algebras", Annals of Mathematics 47 (1946) 122

  8. Enzyme-linked immunosorbent assay using a virus type-specific peptide based on a subdomain of envelope protein e(rns) for serologic diagnosis of pestivirus infections in swine

    NARCIS (Netherlands)

    Langedijk, J.P.; Middel, W.G.; Meloen, R.H.; Kramps, J.A.; Smit, de J.A.

    2001-01-01

    Peptides deduced from the C-terminal end (residues 191 to 227) of pestivirus envelope protein Erns were used to develop enzyme-linked immunosorbent assays (ELISAs) to measure specifically antibodies against different types of pestiviruses. The choice of the peptide was based on the modular structure

  9. The Combined Effects of Classroom Teaching and Learning Strategy Use on Students' Chemistry Self-Efficacy

    Science.gov (United States)

    Cheung, Derek

    2015-01-01

    For students to be successful in school chemistry, a strong sense of self-efficacy is essential. Chemistry self-efficacy can be defined as students' beliefs about the extent to which they are capable of performing specific chemistry tasks. According to Bandura ("Psychol. Rev." 84:191-215, 1977), students acquire information about their…

  10. Motivational Orientation and Burnout among Undergraduate College Students

    Science.gov (United States)

    Pisarik, Christopher T.

    2009-01-01

    This study examined the relationships among motivational orientations based on self-determination theory (Ryan & Deci, 2000b) and burnout among undergraduate college students. A sample of 191 university students was administered the "Academic Motivation Scale" (Vallerand et al., 1992) and the "Maslach Burnout Inventory-Student Survey" (Schaufeli,…

  11. Akromegali Dan Gigantisme

    OpenAIRE

    Silvani, Melati; Pase, M. Aron; Syafril, Santi; Lindarto, Dharma; Solin, Steffie S

    2016-01-01

    Hormon pertumbuhan manusia (Growth Hormone/GH) merupakan peptida rantai tunggal yang terdiri dari 191 asam amino, yang diisolasi dari sel somatotrop pada kelenjar hipofisis anterior pada tahun 1956, dan pertama kali digunakan sebagai terapi untuk penatalaksanaan dwarfisme hipofisis pada tahun 1958. Dwarfisme hipofisis adalah bentuk klasik dari defisiensi hormon pertumbuhan pada anak-anak Melati Silvani

  12. Dicty_cDB: AFG591 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 9 AY271304_1( AY271304 |pid:none) Haemaphysalis longicornis calretic... 204 1e-97 AF052978_1( AF052978 |pid:...none) Dirofilaria immitis calreticulin p... 191 1e-97 AY395261_1( AY395261 |pid:none) Haemaphysalis leporisp

  13. Which Way Did the Bicycle Go?...and Other Intriguing Mathematical Mysteries. Dolciani Mathematical Expositions Series of the Mathematical Association of America, No. 18.

    Science.gov (United States)

    Konhauser, Joseph D. E.; And Others

    This book provides a collection of 191 mathematical problems aimed at the advanced high school student level and above. Problems cover general mathematical areas including plane geometry, three-dimensional geometry, number theory, algebra, combinatorics and graph theory, and a number of miscellaneous questions that combine mathematical…

  14. Identification of Novel Drug Targets and Lead Compounds for Advanced Prostate Cancer through Genomic and Cheminformatic Analyses

    Science.gov (United States)

    2015-08-01

    Med Res Rev 2013;33:1081–118. [18] Guo W, Burris TP, Zhang YH, Huang BL, Mason J, Copeland KC, et al. Genomic sequence of the DAX1 gene: an orphan...191] Maran RR, Thomas A, Roth M, Sheng Z, Esterly N, Pinson D, et al. Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial

  15. Cognition-Based and Affect-Based Trust as Mediators of Leader Behavior Influences on Team Performance

    Science.gov (United States)

    Schaubroeck, John; Lam, Simon S. K.; Peng, Ann Chunyan

    2011-01-01

    We develop a model in which cognitive and affective trust in the leader mediate the relationship between leader behavior and team psychological states that, in turn, drive team performance. The model is tested on a sample of 191 financial services teams in Hong Kong and the U.S. Servant leadership influenced team performance through affect-based…

  16. 77 FR 47050 - Commission Information Collection Activities; Comment Request

    Science.gov (United States)

    2012-08-07

    ..._submission@omb.gov . Attention: Federal Energy Regulatory Commission Desk Officer. The Desk Officer may also...,191 (electronic record-keeping cost) = $369,638] Labor costs: $40,655 [(1,730 hours / 2 \\2\\ = 865... automated collection techniques or other forms of information technology. Dated: August 1, 2012. Kimberly...

  17. COMT Val[superscript 108/158] Met Gene Variant, Birth Weight, and Conduct Disorder in Children with ADHD

    Science.gov (United States)

    Sengupta, Sarojini M.; Grizenko, Natalie; Schmitz, Norbert; Schwartz, George; Amor, Leila Ben; Bellingham, Johanne; de Guzman, Rosherrie; Polotskaia, Anna; Stepanian, Marina Ter; Thakur, Geeta; Joober, Ridha

    2006-01-01

    Objective: In a recent study, Thapar and colleagues reported that COMT "gene variant and birth weight predict early-onset antisocial behavior in children" with attention-deficit/hyperactivity disorder. We have attempted to replicate these findings in a group of ADHD children using a similar research design. Method: Children (n = 191)…

  18. 46 CFR 160.055-1 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ... makes reference to the following documents: (1) Military Specifications: MIL-W-530F—Webbing, Textile... Repellant Treated. MIL-W-17337D—Webbing, Woven, Nylon. MIL-C-43006D—Cloth and Strip Laminated, Vinyl-Nylon... (Artificial Leather). CCC-C-426D—Cloth, Drill, Cotton. (3) Federal Standards: No. 191—Textile Test Methods....

  19. Factorial Structure and Invariance of the Academic Expectations Stress Inventory across Hispanic and Chinese Adolescent Samples

    Science.gov (United States)

    Ang, Rebecca P.; Huan, Vivien S.; Braman, O. Randall

    2007-01-01

    Using confirmatory factor analysis, the current study provided further evidence for the two-factor structure of the Academic Expectations Stress Inventory [AESI; Ang RP, Huan VS (2006) Educ Psych Meas 66:522-539] using a sample of 191 US Hispanic adolescents and a sample of 211 Singapore Chinese adolescents. This study also examined the…

  20. Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

    NARCIS (Netherlands)

    Lefebvre, Philippe; Cariou, Bertrand; Lien, Fleur; Kuipers, Folkert; Staels, Bart

    2009-01-01

    Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation. Physiol Rev 89: 147-191,2009; doi: 10.1152/physrev.00010.2008. - The incidence of the metabolic syndrome has taken epidemic proportions in the past decades, contributing to an incre

  1. The myth of purchasing professionals’ expertise : More evidence on whether computers can make better procurement decisions

    NARCIS (Netherlands)

    Tazelaar, Frits; Snijders, Chris

    2004-01-01

    In a previous experiment, we have shown that risk assessments of purchasing experts are certainly not better than that of subjects untrained in purchasing, and worse than the decisions made by formal models (J. Purchas. Supply Manage. 9 (2003) 191–198). Since both these results are rather counterint

  2. Juhan Parts soovib Res Publica tagasi tippu viia / Toomas Sildam

    Index Scriptorium Estoniae

    Sildam, Toomas, 1961-

    2004-01-01

    Res Publica esimees peaminister Juhan Parts plaanib minna oma erakonnaga kohalikele valimistele ning uurib võimalusi paremerakondade ühinemiseks. Rakveres toimunud erakonna üldkogust. Lisad: Peaministri neli rasket hetke; Res Publica ministrid said parteilt toetuse. Vt. samas: Reformierakond kiitis Res Publicat hea koostöö eest; Parts: 191 vastuhäält on hea tulemus

  3. Vowel devoicing and the perception of spoken Japanese words

    NARCIS (Netherlands)

    Cutler, A.; Otake, T.; McQueen, J.M.

    2009-01-01

    Three experiments, in which Japanese listeners detected Japanese words embedded in nonsense sequences, examined the perceptual consequences of vowel devoicing in that language. Since vowelless sequences disrupt speech segmentation [Norris et al. (1997). Cognit. Psychol. 34, 191–243], devoicing is po

  4. Neurological soft signs discriminating mood disorders from first episode schizophrenia

    NARCIS (Netherlands)

    Boks, MPM; Liddle, PF; Burgerhof, JGM; Knegtering, R; Bosch, RJ

    2004-01-01

    Objective: To investigate the specificity of neurological soft signs (NSS) for first episode schizophrenia compared with mood disorders. Method: We assessed NSS in a sample of 60 healthy controls, 191 first episode psychosis patients and 81 mood disorder patients. We used a principle component analy

  5. Maritime Issues between Pakistan and India: Seeking Cooperation and Regional Stability

    Science.gov (United States)

    2012-12-01

    2, ( JSTOR , Sage Publications, Apr-June 2005), 191. 67 exchange, some promising small steps also include the resolution of such less contentious...Pakistan,” Alternatives: Global, Local, Political, Vol. 30, No. 2, ( JSTOR , Sage Publications, Apr-June 2005). “India, Pakistan in War of Words as

  6. Volumetric T-spline Construction Using Boolean Operations

    Science.gov (United States)

    2013-07-01

    15213, USA 2 Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX 78712, USA 3 Department of Civil and...and S. Yau. Volumetric harmonic map. Communications in Information and Systems, 3(3):191–202, 2003. 12. C.A.R. Guerra . Simultaneous untangling and

  7. Martin Guerre ei tulnud tagasi üksi / Jürgen Beyer ; saksa keelest tõlkinud Tiina Lias

    Index Scriptorium Estoniae

    Beyer, Jürgen, 1965-

    2002-01-01

    Rets. rmt.: Davis, Natalie Zemon. Martin Guerre'i tagasitulek / inglise keelest tõlkinud Ainiki Väljataga. Tallinn : Varrak, 2002. Arvustus ilmus ka ajakirjas Vikerkaar, 2002, nr. 8-9 lk. 189-191, kuna käesolevast numbrist oli välja jäänud üks lõik

  8. Validity of Mixed 2D and 3D Cadastral Parcels in the Land Administration Domain Model

    NARCIS (Netherlands)

    Thompson, R.J.; Van Oosterom, P.J.M.

    2012-01-01

    In the move towards a 3D Cadastre, many jurisdictions are considering a hybrid 2D/3D database as either a stage of development or as a target in itself (van Oosterom, Stoter, Ploeger, Thompson and Karki 2011). The Land Administration Domain Model (LADM), which is the underlying model for the ISO 191

  9. A Computational Model for Observation in Quantum Mechanics.

    Science.gov (United States)

    1987-03-16

    Computer Science Technical Report No. 191, May 1986. [Feynman63j Feynman , R. P., Leighton, R. B., and Sands, M. The Feynman Lectures on Physics...MIT Artificial Intelligence Laboratory Memo 380, Sept. 1976. [Wheeler83] Wheeler , J. A., and Zurek, W. H. Quantum Theory and Measuremrent 72 .4

  10. Graphic/Symbol Segmentation for Group 4 Facsimile Systems.

    Science.gov (United States)

    1982-04-01

    question de construire cc syst~me inttgrt "en bloc" maim bien au contraire de proceder par #tapes. par paliers successifs. Certaines applications. dont la...34 Electroft Comnsun. J1w.. vide a good 1 mnin facsimile standard. The optional two. vol. SA, no. 2, pp. 30-35. 191S. 1121 T. S. Huang and A. B. Humain

  11. Mentors in Life and at School: Impact on Undergraduate Protege Perceptions of University Mission and Values

    Science.gov (United States)

    Ferrari, Joseph R.

    2004-01-01

    University undergraduates (84 women, 80 men: M age=19.1 years old) reported school mission and value perceptions, life and/or school mentor relationships, and social desirability tendencies. No significant social desirability effect was obtained. Proteges with mentors at school and in life (n=52) reported greater cognitive and informational…

  12. 4 CFR 25.9 - Soliciting, vending, and debt collection.

    Science.gov (United States)

    2010-01-01

    ... the “Manual on Fund Raising Within the Federal Service,” issued by the U.S. Office of Personnel... Reform Act of 1978 (Pub. L. 95-454) or the General Accounting Office Personnel Act of 1980, Public Law 96-191 (31 U.S.C. sec. 732(e)); (d) Occupants of space leased for commercial purposes, or made...

  13. Dicty_cDB: Contig-U13293-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 093214_1( AF093214 |pid:none) Hirtodrosophila pictiventris xanth... 206 6e-52 FB7...23 |pid:none) Sequence 7019 from Patent WO200903... 191 2e-47 AF058984_1( AF058984 |pid:none) Scaptodrosophila

  14. Development of Understanding and Self-Confidence in Mathematics; Grades 5-8

    Science.gov (United States)

    Hannula, Markku S.; Maijala, Hanna; Pehkonen, Erkki

    2004-01-01

    This paper presents some preliminary results of the longitudinal aspect of a research project on self-confidence and understanding in mathematics. We have collected a survey data of 3057 fifth-graders and seventh-graders and a follow-up data of ten classes (191 pupils) one and a half years later. The longitudinal data indicates that the learning…

  15. 78 FR 33120 - Final Interim Staff Guidance LR-ISG-2011-04; Updated Aging Management Criteria for Reactor Vessel...

    Science.gov (United States)

    2013-06-03

    ... Evaluation Guidelines (MRP-227-A), dated December 2011 (ADAMS Accession No. ML12017A193 [Transmittal letter from the EPRI-MRP] and ADAMS Accession Nos. ML12017A194, ML12017A196, ML12017A197, ML12017A191... ensure consistency with MRP-227-A and provides a framework to ensure that PWR license renewal...

  16. Trimeniaceae

    NARCIS (Netherlands)

    Philipson, W.R.

    1984-01-01

    Trimenia was first described by SEEMANN as a genus related to the Ternstroemiaceae. BENTHAM & HOOKER ƒ. (1880) regarded it as more closely related to the Monimiaceae without definitely placing it there. This was done by PERKINS & GILG (1901) who formed the tribe Trimenieae of that family. GIBBS (191

  17. GETDB: 114084 [GETDB

    Lifescience Database Archive (English)

    Full Text Available 114084 Link to Original w[*] P{GawB}NP7121 / FM7c 19E7 Link to DGRC Genome Viewer: 114084 Quasimo...Site 19E7 Map Viewer Link to DGRC Genome Viewer: 114084 Related Genes Quasimodo{}189 1360{}190 Rt1c{}191 Ori

  18. Analysis of timber and coating material on an iron anchor recovered off Aguada Bay, Goa

    Digital Repository Service at National Institute of Oceanography (India)

    Tripati, S.; Rao, B.R.; Shashikala, S.; Rao, R.V.; Khedekar, V.D.

    , 160, 103–119. 7. Sahai, A. and Srivastava, R. K., Structural and geochemical char- acteristics of amphibolites from the Bhagirathi and Yamuna val- leys of Main Central Thrust Zone, Garhwal Himalaya. Himalayan Geol., 1997, 18, 191–201. 8. Srivastava...

  19. 40 CFR 194.51 - Consideration of protected individual.

    Science.gov (United States)

    2010-07-01

    ... COMPLIANCE WITH THE 40 CFR PART 191 DISPOSAL REGULATIONS Compliance Certification and Re-certification Individual and Ground-Water Protection Requirements § 194.51 Consideration of protected individual... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Consideration of protected...

  20. Transforming Graph Data for Statistical Relational Learning

    Science.gov (United States)

    2012-10-01

    of centrality for asymmetric relations. Social Networks, 23 (3), 191–201. Borgman, C., & Furner, J. (2002). Scholarly communication and bibliometrics ...general theory of bibliometric and other cumulative advantage processes. Journal of the American Society for Information Science, 27 (5), 292–306. Pudil

  1. Role of cutaneous surface fluid in frog osmoregulation

    DEFF Research Database (Denmark)

    Larsen, Erik Hviid; Ramløv, Hans

    2013-01-01

    The study investigated whether evaporative water loss (EWL) in frogs stems from water diffusing through the skin or fluid secreted by mucous glands. Osmolality of cutaneous surface fluid (CSF) of Rana esculenta (Pelophylax kl. esculentus) subjected to isoproterenol or 30 °C–34 °C was 191 ± 9...

  2. Relationship between Acceptable Noise Level and the Abbreviated Profile of Hearing Aid Benefit

    Science.gov (United States)

    Freyaldenhoven, Melinda C.; Nabelek, Anna K.; Tampas, Joanna W.

    2008-01-01

    Purpose: This study investigated the relationship between acceptable noise levels (ANLs) and the Abbreviated Profile of Hearing Aid Benefit (APHAB; R. M. Cox & G. C. Alexander, 1995). This study further examined the APHAB's ability to predict hearing aid use. Method: ANL and APHAB data were collected for 191 listeners with impaired hearing,…

  3. Defense Nuclear Agency Reaction Rate Handbook. Second Edition. Revision Number 6

    Science.gov (United States)

    1972-03-01

    257 (1972). 17-55. Gilmore, F. R., J. Quant. Spectry. Radiative Transfer S_t 369(1965). 17-56. Herzberg , G., Electronic Spectra of...1F»O •BBS • \\ CHAPTER 19 19. NEUTRAL REACTIONS Frederick Kaufman, University of Pittsburgh (Latest Revision 14 May 1975) o 19.1

  4. A Narrative Approach to Ethnic Identity in Emerging Adulthood: Bringing Life to the Identity Status Model

    Science.gov (United States)

    Syed, Moin; Azmitia, Margarita

    2008-01-01

    This study used a narrative approach to understand how emerging adults experience ethnicity in their everyday lives and to link ethnic identity processes with the content of how ethnic identity is experienced. Participants were 191 ethnically diverse emerging adults who completed the Multigroup Ethnic Identity Measure (MEIM) and provided a written…

  5. The Development, Validation and Use of the Rural and Remote Teaching, Working, Living and Learning Environment Survey (RRTWLLES)

    Science.gov (United States)

    Dorman, Jeffrey; Kennedy, Joy; Young, Janelle

    2015-01-01

    Research in rural and remote schools and communities of Queensland resulted in the development and validation of the Rural and Remote Teaching, Working, Living and Learning Environment Survey (RRTWLLES). Samples of 252 teachers and 191 community members were used to validate the structure of this questionnaire. It was developed within the standard…

  6. Interpersonal Relationships and Emotional Distress in Adolescence

    Science.gov (United States)

    Kenny, Rachel; Dooley, Barbara; Fitzgerald, Amanda

    2013-01-01

    The aim of this study was to examine positive and negative qualities in adolescents' interpersonal relationships and their relative importance in predicting emotional distress. Participants were 260 students from three schools in the Dublin area (119 girls; 141 boys), aged 12-18 years (M = 15.32, SD = 1.91). Students completed questionnaires…

  7. Biplanes and Bombsights, British Bombing in World War I

    Science.gov (United States)

    1999-05-01

    of Frank Halford’s power plant, which had been de- rived from a contemporary Hispano- Suiza model.9 In July 1917, early in the program, it was...Brig Gen Sir David: 6, 35, 39 highest battle losses: 195 highest sick rate: 195 Hispano- Suiza model: 191 HQ RFC: 48 Hyderabad Squadron: 201 304 I.F

  8. Driving things

    DEFF Research Database (Denmark)

    Nevile, Maurice Richard

    2015-01-01

    ) Automobilities. London: Sage. Haddington, P., Keisanen, T. & Nevile, M. (Eds.) (2012) Meaning in motion: Interaction in cars. Special Issue for Semiotica, 191, 1/4. Haddington, P., Keisanen, T., Mondada, L., & Nevile, M. (Eds.) (2014) Multiactivity in social interaction: Beyond multitasking. Amsterdam...

  9. High-Pressure Freezing, Crystal Structure Studies and Si-CF3 Bond Polarizability of Trimethyl(trifluoromethyl)silane (Postprint)

    Science.gov (United States)

    2008-11-01

    Diffus. Forum 208–209 (2002) 319–322. [37] L.J. Barbour, J. Supramol. Chem. 1 (2001) 189–191. [38] Persistence of Vision (TM) Raytracer , version 2.6, Persistence of Vision Pty. Ltd., Williamstown, Victoria, Australia, 2004.

  10. Does the Past Have a Place in the Future? The Utility of Battleships in the Twenty-First Century.

    Science.gov (United States)

    2007-11-02

    shells from their stowage to the hoists. Surface Action Group (SAG. Usually a command ship accompanied by escorts tasked to conduct operations...vulnerable than the cruiser" (Reilly 1989, 191). From day one on-station (30 September 1968), the New Jersey was a success, racking up mission after

  11. Development of a Model of Soldier Effectiveness: Retranslation Materials and Results

    Science.gov (United States)

    1987-05-01

    sion training exercise with seven aggres- sors against one soldier, this soldier quickly found the best escape route and accomplished his mission...PERFORMANCE EFFECTIVENESS CATEGORY LEVEL 191. When apprehended for possession of mari- juana , this soldier agreed to work close- ly with his NCO to

  12. 16 CFR 1611.33 - Test procedures for textile fabrics and film.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Test procedures for textile fabrics and film... procedures for textile fabrics and film. (a)(1) All textile fabrics (except those with a nitro-cellulose... Clothing Textiles, Commercial Standard 191-53”. (2) Notwithstanding the provisions of paragraph (a)(1)...

  13. Budget Update, November 9, 2010. Report 10-20

    Science.gov (United States)

    Woolfork, Kevin

    2010-01-01

    On October 8, Governor Arnold Schwarzenegger signed the 2010-11 Budget Act for the State of California. This budget was the outcome of many months of negotiation between the Governor and the Legislature. The Governor vetoed $963 million in spending from the Legislature's budget, arriving at a budget that addresses an estimated $19.1 billion…

  14. EST Table: CK561988 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK561988 rswpb0_004912.y1 10/09/29 64 %/191 aa ref|XP_001605087.1| PREDICTED: similar to fetal alzhe... PREDICTED: similar to fetal alzheimer antigen, falz [Tribolium castaneum] CK536202 swp ...

  15. The Shock and Vibration Digest. Volume 17, Number 1

    Science.gov (United States)

    1985-01-01

    the worst-case design 85-192 formulation and the hybrid formulation Analysis of HCDA for the point-wise state variable Y.W. Chang constraints. The...hypothet- ical core-disrupti-e accident ( HCDA ) 85-191 analysis and their applications to * Inverse Perturbation Method for Struc- liquid metal fast

  16. Inclusive Education in Japan and Korea--Japanese and Korean Teachers' Self-Efficacy and Attitudes towards Inclusive Education

    Science.gov (United States)

    Song, Jia

    2016-01-01

    The current study aims to evaluate teachers' self-efficacy and attitudes towards inclusive classrooms in Japan and Korea. Teachers' Sense of Efficacy Scale (TSES; Tschannen-Moran and Woolfolk, [Tschannen-Moran, M., 2001]) and Scale of Teachers' Attitudes Towards Inclusive Classrooms (STATIC; Cochran, [Cochran, H., 1998]) were completed by 191

  17. Process audits versus product quality monitoring of bulk milk

    NARCIS (Netherlands)

    Velthuis, A.G.J.; Asseldonk, van M.A.P.M.

    2011-01-01

    The aim was to investigate whether on-line somatic cell count (SCC) assessment, when combined with electrical conductivity (EC), should be implemented at the udder quarter or at the cow level. Data were collected from 3 farms with automatic milking systems, resulting in 3,191 quarter milkings used i

  18. Somatic cell count assessment at the quarter or cow milking level

    NARCIS (Netherlands)

    Mollenhorst, H.; Tol, van der P.P.J.; Hogeveen, H.

    2010-01-01

    The aim was to investigate whether on-line somatic cell count (SCC) assessment, when combined with electrical conductivity (EC), should be implemented at the udder quarter or at the cow level. Data were collected from 3 farms with automatic milking systems, resulting in 3,191 quarter milkings used i

  19. Locus of Control, Attitudes toward Education, and Teaching Behaviors.

    Science.gov (United States)

    Kremer, Lya

    1982-01-01

    Tests 191 elementary school teachers in northern Israel for the relationships among locus of control, traditional and progressive educational attitudes, and related teaching behaviors. Finds external and internal locus of control explain the variance in traditional and progressive attitudes, respectively, and teaching behaviors. (Author/LC)

  20. Juhatuse liikme vastu esitatavate nõuete aegumise erandlik viieaastane tähtaeg: kas õigustatud anomaalia või põhjendamatu kõrvalekalle? / Kärt Pormeister

    Index Scriptorium Estoniae

    Pormeister, Kärt, 1990-

    2013-01-01

    8. mai 2013. aasta Riigikohtu lahendist 3-2-1-191-12, milles kohus otsustas tsiviilõiguslike nõuete aegumise osas üheselt, et äriühingu poolt tema juhatuse liikme vastu esitatavale kahju hüvitamise nõudele kohaldub üksnes viieaastane aegumistähtaeg

  1. Assessing Semantic Knowledge Using Computer-Based and Paper-Based Media

    Science.gov (United States)

    1992-01-01

    92152-6800 JN-92-09 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSORING/MONITORING Computers in Human Behavior : Vol. 8, pp. 169-191... Computers in Human Behavior . 1, 49-58. Lushene, R. E, O’Neil. It. F.. & Dunn. T. (1974) Equivalent validity of a completely computerized MMPI. Journal of

  2. Losing Sleep over It: Daily Variation in Sleep Quantity and Quality in Canadian Students' First Semester of University

    Science.gov (United States)

    Galambos, Nancy L.; Dalton, Andrea L.; Maggs, Jennifer L.

    2009-01-01

    Daily covariation of sleep quantity and quality with affective, stressful, academic, and social experiences were observed in a sample of Canadian 17-19-year-olds in their first year of university. Participants (N = 191) completed web-based checklists for 14 consecutive days during their first semester. Multilevel models predicting sleep quantity…

  3. Attachment, Stress, Dyadic Coping, and Marital Satisfaction of Counseling Graduate Students

    Science.gov (United States)

    Fuenfhausen, Kerrie K.; Cashwell, Craig S.

    2013-01-01

    A sample of 191 married students from 23 Council for Accreditation of Counseling and Related Educational Programs-accredited programs participated in a survey designed to examine factors that affect the marital satisfaction of counseling graduate students. Results indicated that attachment anxiety, attachment avoidance, and dyadic coping accounted…

  4. EST Table: AU004523 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available AU004523 ws20564 10/09/28 96 %/143 aa ref|NP_001040215.1| stathmin [Bombyx mori] gb|ABD36259.1| stathmin...7-PA 10/09/10 43 %/191 aa gi|91083957|ref|XP_975021.1| PREDICTED: similar to stathmin [Tribolium castaneum] FS915193 ws2 ...

  5. An Exploratory Study of Library Anxiety in Developmental Education Students

    Science.gov (United States)

    Lee, Scott W.

    2012-01-01

    This study examined Library Anxiety in a cohort of developmental English students. Levels of anxiety were measured in 191 students using Bostick's Library Anxiety Scale. Thirteen of those students were then interviewed about their use, knowledge and valuation of their campus library. The results of the interviews were compared against the measured…

  6. AcEST: DK951335 [AcEST

    Lifescience Database Archive (English)

    Full Text Available + Sbjct: 751 KTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQE 810 Que...1 K K++ L + + +ES+ ++ +AELGTDL+ L+ E++ + +LN EI +L+++ Sbjct: 751 KTFMPKQRSLQSLEASLHAMESTRES...L+ L+ E++ + +LN EI +L+++ Sbjct: 751 KTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQE 810 Query: ...EKALLSSLNPEIMKLKEK 191 K K++ L + + +ES+ ++ +AELGTDL+ L+ E++ + +LN EI +L+++ Sbjct: 751 KTFMPKQRSLQSLEASLHAMESTRES...+ E++ + +LN EI +L++K Sbjct: 751 KTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLPSQLSLEDQKRVDALNDEIRQLQQK 810 Query: 192

  7. Variation in the Helical Structure of Native Collagen

    Science.gov (United States)

    2014-02-24

    Hongo C, Noguchi K (2006) Helical twists of collagen model peptides. Biopolymers 84: 421–432. 39. Kramer R, Bella J, Mayville P, Brodsky B, Berman H...Iguchi M, Noguchi K (2006) Revision of collagen molecular structure. Biopolymers 84: 181–191. 43. Shoulders MD, Raines RT (2009) Collagen structure

  8. 46 CFR 164.023-3 - Specifications and standards incorporated by reference.

    Science.gov (United States)

    2010-10-01

    ...) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL MATERIALS Thread for Personal Flotation...-6030, or go to: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html... Standard No. 191A, Textile Test Methods, July 20, 1978: (1) Method 4010, Length-Weight Relation;...

  9. Block Motion from Detonations of Buried Near-Surface Explosive Arrays

    Science.gov (United States)

    1980-12-01

    Estancia Valley, 45 miles east only attempt at using a nonplanar explosive ar- of Albuquerque, New Mexico, in a rather compli- ray designed to focus the...Pratt, H., Oration, I.L. and Zbur, R. (1%91 Geology and and iI and PLANEWAVE I aiid II AFWL-TR-69-12 material properties of the Estancia Valley test site

  10. EST Table: FS765648 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 72 %/182 aa ref|XP_001658413.1| neuroendocrine differentiation factor [Aedes aegypti] gb|EAT40780.1| neuroendocrine... %/191 aa gnl|Amel|GB15107-PA 10/09/10 68 %/187 aa gi|91089815|ref|XP_968988.1| PREDICTED: similar to neuroendocrine differentiation factor [Tribolium castaneum] FS765648 fcaL ...

  11. Leadership in Distance Education: Qualities and Qualifications Sought by Higher Education Institutions

    Science.gov (United States)

    Nworie, John; Haughton, Noela; Oprandi, Stephanie

    2012-01-01

    This article presents the results of an investigation into the qualities and qualifications sought in distance education leaders by institutions of higher education in the United States. The researchers examined 191 distance education leadership position announcements posted by online sources between 1997 and 2010. Content analysis of these…

  12. Measuring Small-Group Environments: A Validity Study of Scores from the Salter Environmental Type Assessment and the Group Environment Scale

    Science.gov (United States)

    Salter, Daniel W.; Junco, Reynol

    2007-01-01

    This concurrent validity study of Salter Environmental Type Assessment scores was conducted with the Group Environment Scale. A principal components factor analysis with varimax rotation of 191 college students' responses suggested two factors that accounted for 51% of the variance. The factor-analytic results and concurrent validity coefficients…

  13. A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1

    NARCIS (Netherlands)

    Bánfi, B; Maturana, A; Jaconi, S; Arnaudeau, S; Laforge, T; Sinha, B; Ligeti, E; Demaurex, N; Krause, K H

    2000-01-01

    Voltage-gated proton (H+) channels are found in many human and animal tissues and play an important role in cellular defense against acidic stress. However, a molecular identification of these unique ion conductances has so far not been achieved. A 191-amino acid protein is described that, upon hete

  14. 40 CFR 194.53 - Consideration of underground sources of drinking water.

    Science.gov (United States)

    2010-07-01

    ... of drinking water. 194.53 Section 194.53 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... underground sources of drinking water. In compliance assessments that analyze compliance with part 191, subpart C of this chapter, all underground sources of drinking water in the accessible environment...

  15. Thermal Fronts and Cross-Frontal Heat Flux in the Southern Yellow Sea and the East China Sea

    Science.gov (United States)

    2008-01-01

    lateral eddy diffusivity HTA are 12 expressed by 13 2 2 2 , , V T VH TT T TvT A z y T TA A z y...Korea Strait in early winter. J. Korean Soc. Oceanogr., 19(1), 56-67. 22 31 Lee, J.-H., H.-J. Lie, and C.-H. Cho (2003) The structure of ocean

  16. Developments and trends in soil science: 100 volumes of Geoderma (1967-2001)

    NARCIS (Netherlands)

    Hartemink, A.E.; McBratney, A.B.; Cattle, J.A.

    2001-01-01

    Between September 1967 and March 2001, Geoderma published 100 volumes containing 2079 papers covering 31,637 pages and filling 191 cm of shelf space. No doubt that is a lot of paper, but what is in it? This paper starts with a brief history of the journal and an overview of editors and a geographic

  17. Local Marine Geoid Variations and Jason-2 Bias Determination using the Gavdos Permanent Cal/Val Facility

    DEFF Research Database (Denmark)

    Mertikas, S. P.; Daskalakis, A.; Tziavos, I. N.;

    2012-01-01

    , but others are related to under-sampling of the Earth's gravity field due to the resolution of the geoid model. New reference surfaces for calibration have thus emerged. Finally, new updated values for the Jason-2 altimeter bias have been determined as 191.81 ± 2.80 mm with the geoid model and as 181.51 ± 2...

  18. AcEST: BP920718 [AcEST

    Lifescience Database Archive (English)

    Full Text Available RS2|SRCAP_HUMAN Helicase SRCAP OS=Homo sapiens GN=SRCAP PE... 76 8e-14 sp|Q9NDJ2|DOM_DROME Helicase domino O... HLDF+VGQTE+YS +L++ Sbjct: 191 LRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQ 249 >sp|Q9NDJ2|DOM_DROME Helicase domino

  19. The World Calls for a Strong United Nations—In Commemoration of the 60th Anniversary of the UN

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    On September 14-16, 2005, the 2005 World Summit, UN’s largest summit meeting of heads of state and government in the new century, was held. 170 heads of state and government out of 191 member states gathered at the UN headquarters in New York, celebrating the 60th anniversary of the United

  20. National Dam Safety Program. Hilliard Estates Lake Dam (MO 20473), Osage - Gasconade River Basin, Greene County, Missouri. Phase I Inspection Report.

    Science.gov (United States)

    1981-03-01

    Tributary of the Little Pomme de Terre Date of Inspection: November 19, 1980 Hlilliard Estates Lake Dam was inspected by an interdiscip)- linary team... Terre River. The dam and lake are within the Strafford, Missouri 7.5 minute quadrangle sheet (Section 15, T3ON, R20W - latitude 37°19.1’ longitude

  1. A Survey of the Theory of the Boundedness, Stability, and Asymptotic Behavior of Solutions of Linear and Non-Linear Differential and Difference Equations

    Science.gov (United States)

    1949-01-01

    Math. Jour. 11* {191»?), pp. 83-97. k. Borel, E., Lecons sur les Series Divergentes , Geuthier- i Vlllars, 1901. 1 5. Butlewski, Z... divergentes , Annales de l’Ecole Normale Superieure, vol. 16 (1899), pp. 9-136, pp. 26 ff. 7. Boutroux, P., Lecona aur lea functions d^finlea

  2. Iwo Jima: The Unnecessary Battle

    Science.gov (United States)

    2011-03-25

    Fred, Samurai ! (New York: Nelson Doubleday Inc. 1957). Schmidt, Harry Schmidt, Lieutenant General, U.S. Marine Corps, IWO JIMA, Commanding...191-202. 21 Alexander 14. 22 Alexander 14. 23 Saburo Sakai, Martin Caidan, and Fred Saito, Samurai ! (New York: Nelson Doubleday Inc. 1957), 276

  3. Fundamentals for remote structural health monitoring of wind turbine blades - a preproject. Annex E. Full-scale test of wind turbine blade, using sensors and NDT

    DEFF Research Database (Denmark)

    Kristensen, O.J.D.; McGugan, Malcolm; Sendrup, P.

    2002-01-01

    A 19.1 metre wind turbine blade was subjected to static tests. The purpose of the test series was to verify the abilities of different types of sensors to detect damage in wind turbine blades. Prior to each of the static test-series an artificial damagewas made on the blade. The damage made...

  4. Field Medical Surveillance System User’s Manual

    Science.gov (United States)

    2013-01-31

    Paronychia/Infection - Toe 517. Gangrene 518. Necrotizing Fasciitis 519.Impetigo 520.Local Infection/Lesion - Skin 521.Skin Disease - Other 522...190.Nanophyetiasis 165.Marburg virus disease 191. Necrotizing skin/soft tissue infx. 166.Mayaro 192.Neutropenic typhlitis 167.Measles 193.New World

  5. VizieR Online Data Catalog: HK photometry in an UCHII region near Sh2-217 (Brand+, 2011)

    Science.gov (United States)

    Brand, J.; Massi, F.; Zavagno, A.; Deharveng, L.; Lefloch, B.

    2010-11-01

    Coordinates and photometric parameters (magnitudes and colours) are presented of the stars located in a molecular condensation on the SW-border of the Galactic HII region Sh2-217. The data were obtained on January 4, 2004 with the 3.58-m Telescopio Nazionale Galileo (TNG; La Palma, Canary Islands, Spain). Near-infrared observations were carried out through H and K' broad-band filters with the camera NICS. The image scale is 0.25arcsec/pixel, yielding a field of view of about 4.2'x4.2'. Observing strategy and exposure times are described in Deharveng et al. (2006A&A...458..191D), the only difference being that the dithering sequence for the H-band images was the same as adopted for K'. The data reduction steps adopted are outlined in Deharveng et al. (2006A&A...458..191D). Aperture photometry was done using the DAOPHOT package in IRAF. We followed the same procedure described in Deharveng et al. (2006A&A...458..191D) to obtain aperture photometry, after which PSF-fitting photometry was performed. Although the seeing was good (image of a sample of stars and fitting those positions to the equatorial coordinates given by Deharveng et al. (2006A&A...458..191D), using tasks of STSDAS/IRAF. The typical accuracy of this procedure is of the order of 1". (1 data file).

  6. Scouring and dyeing of T/C knitted fabric in one bath%涤棉针织物练染同浴工艺

    Institute of Scientific and Technical Information of China (English)

    陈宏武; 张伟; 张艳

    2013-01-01

    选用精练剂M-191A,Argazol NF型活性染料和Artelon AQE型分散染料,设计相应的工艺实现涤棉针织物同浴练染.优化的处理工艺为:M-191A 2g/L,50℃处理30 min,加入染料和元明粉,130 ℃染色40min;水洗、皂洗、水洗.染中、深色时,同浴练染工艺染色效果和色牢度与传统工艺相当.%Scouring and dyeing of polyester/cotton knitted fabric in one bath is carried out with scouring agent M-191A, reactive dyes Argazol NF and disperse dyes Artelon AQE. The optimized process is as follows: M-191A2 g/L,scouring at 50 ℃ for 30 min, then dyes and anhydrous sodium sulfate are added, dyeing at 130 ℃ for 40 min, then washing, soaping, and washing. Dyeing results and color fastness of medium to dark color are similar to those of traditional process. Scouring and dyeing in one bath has advantages of short and efficient process, water, energy and steam-saving, as well as improved production efficiency.

  7. GaAs FET Logic at Low Temperatures.

    Science.gov (United States)

    1983-08-01

    applications. The transfer characteristics of a unit logic cell is shown in The results shown in Table I are for substrates from " quail - Fig. 5(a). The gain...TYPICAL RING OSCILLATOR CIRCUIT DURING LIFE TESI CELL TYPE: BFL (A) SLICE: C49 GATE LENGTH: 0.5 PM (Vp>: -1.91 V FO = Fl = I CIRCUIT NO: 7 RO LENGTH: 11

  8. Joint Light Tactical Vehicle (JLTV)

    Science.gov (United States)

    2015-12-01

    demilitarization / demilitarization second destination tranportation repairable and consumerable parts associated with government furnished equipment / end...Details Date of Estimate: December 31, 2015 Source of Estimate: POE Disposal/ Demilitarization Total Cost (BY 2012 $M): Total costs for disposal...of all Vehicle are 191.5 Total Demilitarization Cost includes costs for disposal and transportation associated with disposal of JLTVs. The costs

  9. Test Anxiety, Stress, and Social Support

    Science.gov (United States)

    1981-03-02

    have been killed in combat, are more likely to develop combat exhaustion than soldiers who belong to intact units. Bowlby (1969, 1973), after an...theory of behavioral change. Psychological Review, 1977, 84 (2), 191-215. Bowlby , J. Attachment. New York: Basic Books, 1969. Bowlby , J. Separation

  10. 77 FR 5472 - Pipeline Safety: Miscellaneous Changes to Pipeline Safety Regulations

    Science.gov (United States)

    2012-02-03

    ... amendments to the pipeline safety regulations (76 FR 73570). On January 12, 2012, the Interstate Natural Gas... Pipeline and Hazardous Materials Safety Administration 49 CFR Parts 191, 192 and 195 RIN 2137-AE59 Pipeline Safety: Miscellaneous Changes to Pipeline Safety Regulations AGENCY: Pipeline and Hazardous...

  11. Multiwavelength analysis of the intriguing GRB 061126: The reverse shock scenario and magnetization

    NARCIS (Netherlands)

    Gomboc, A.; Kobayashi, S.; Guidorzi, C.; Melandri, A.; Mangano, V.; Sbarufatti, B.; Mundell, C.G.; Schady, P.; Smith, R.J.; Updike, A.C.; Kann, D.A.; Misra, K.; Rol, E.; Pozanenko, A.; Castro-Tirado, A.J.; Anupama, G.C.; Bersier, D.; Bode, M.F.; Carter, D.; Curran, P.; Fruchter, A.; Graham, J.; Hartmann, D.H.; Ibrahimov, M.; Levan, A.; Monfardini, A.; Mottram, C.J.; O'Brien, P.T.; Prema, P.; Sahu, D.K.; Steele, I.A.; Tanvir, N.R.; Wiersema, K.

    2008-01-01

    We present a detailed study of the prompt and afterglow emission from Swift GRB 061126 using BAT, XRT, UVOT data and multicolor optical imaging from 10 ground-based telescopes. GRB 061126 was a long burst (T90 = 191 s) with four overlapping peaks in its γ-ray light curve. The X-ray afterglow, observ

  12. What Shapes Adolescents' Future Perceptions? The Effects of Hearing Loss, Social Affiliation, and Career Self-Efficacy

    Science.gov (United States)

    Michael, Rinat; Cinamon, Rachel Gali; Most, Tova

    2015-01-01

    The current study examined the contribution of hearing loss, social affiliation, and career self-efficacy to adolescents' future perceptions. Participants were 191 11th and 12th grade students: 60 who were deaf, 36 who were deaf or hard of hearing, and 95 who were hearing. They completed the Future Perceptions Scale, the Career Decision-Making…

  13. 75 FR 9359 - Drawback of Internal Revenue Excise Tax

    Science.gov (United States)

    2010-03-02

    ... Parts 113 and 191 RIN 1505-AC18 Drawback of Internal Revenue Excise Tax AGENCY: Customs and Border... Regulations to: preclude the filing of a substitution drawback claim for internal revenue excise tax paid on imported merchandise in situations where no excise tax was paid upon the substituted merchandise or...

  14. The Role of PD-1 Ligand in Immune Evasion by Breast Cancer

    Science.gov (United States)

    2005-05-01

    tonsillectomy as previously described (27). Adherent FDC were harvested with 5 mM EDTA in PBS and thoroughly washed. To block FcR on FDC, the cells were...mice. J. Exp. Med. 191:891. 39. Bleul, C. C., and T. Boehm. 2001. Laser capture microdissection-based expres- sion profiling identifies PD1-ligand as

  15. Attachment Styles as a Predictor of Emotional Intelligence

    Science.gov (United States)

    Hamarta, Erdal; Deniz, M. Engin; Saltali, Neslihan

    2009-01-01

    The purpose of this study is to examine if attachment styles predict emotional intelligence (intrapersonal, interpersonal, adaptability, stress management, and general mood). Participants of the study consisted of 463 (272 females, 191 males) undergraduate students selected randomly from different faculties of Selcuk University. Regression and…

  16. AcEST: BP920061 [AcEST

    Lifescience Database Archive (English)

    Full Text Available |Q108T9|CTTB2_LOXAF Cortactin-binding protein 2 OS=Loxodonta a... 32 1.4 sp|Q00PJ1|CTTB2_ATEAB Cortactin-bin...++ L +K Sbjct: 191 KLEEVMAKLEEEKKK 205 >sp|Q108T9|CTTB2_LOXAF Cortactin-binding protein 2 OS=Loxodonta afric

  17. The influence of female and male body mass index on live births after assisted reproductive technology treatment

    DEFF Research Database (Denmark)

    Petersen, Gitte Lindved; Schmidt, Lone; Pinborg, Anja;

    2013-01-01

    . Analyses were adjusted for age and smoking at treatment initiation and results stratified by BMI groups and presented by IVF/ICSI treatment. RESULT(S): In total, 12,566 women and their partners went through 25,191 IVF/ICSI cycles with 23.7% ending in a live birth. Overweight and obese women with regular...

  18. On Matroids and Linearly Independent Set Families

    OpenAIRE

    2013-01-01

    New families of matroids are constructed in this note. These new fami- lies are derived from the concept of linearly independent set family (LISF) introduced by Eicker and Ewald [Linear Algebra and its Applications 388 (2004) 173-191]. The proposed construction generalizes in a natural way the well known class of vectorial matroids over a field.

  19. Results of the Cord Blood Transplantation Study (COBLT) : clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies

    NARCIS (Netherlands)

    Kurtzberg, Joanne; Prasad, Vinod K.; Carter, Shelly L.; Wagner, John E.; Baxter-Lowe, Lee Ann; Wall, Donna; Kapoor, Neena; Guinan, Eva C.; Feig, Stephen A.; Wagner, Elizabeth L.; Kernan, Nancy A.

    2008-01-01

    Outcomes of unrelated donor cord blood transplantation in 191 hematologic malignancy children (median age, 7.7 years; median weight, 25.9 kg) enrolled between 1999 and 2003 were studied (median follow-up, 27.4 months) in a prospective phase 2 multicenter trial. Human leukocyte antigen (HLA) matching

  20. Dicty_cDB: Contig-U12508-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available P001055 |pid:none) Elusimicrobium minutum Pei191, c... 38 0.50 M64787_1( M64787 |pid:none) E.coli sbc...0 AE005674_334( AE005674 |pid:none) Shigella flexneri 2a str. 301, c... 38 0.50 ( P13458 ) RecName: Full=Nuclease sbc

  1. Neuropathy Target Esterase in Brain Function and Deterioration Caused by Cholinesterase Inhibiting Chemicals

    Science.gov (United States)

    2005-08-01

    Warfare Agents: Toxicology and Treatment (Wiley, New York). 3. Taylor, P. (2001) in Goodman & Gilman’s The Pharmacological Basis of Therapeutics, eds...Hardman, J. G., Limbird, L. E. & Gilman , A. G. (McGraw– Hill, New York), 10th Ed., pp. 175–191. 4. Johnson, M. K. & Glynn, P. (2001) in Handbook of

  2. In vivo Oxime Administration Does Not Influence Ellman Acetylcholinesterase Assay Results

    Science.gov (United States)

    2009-01-01

    tylchotinesterase inhibition by organophosphates In vitro. Arch ToxlcoI45:21-27. Taylor P. 2001. AntichoUnesterase agents, In: HardmDO IG, Limbird LE. Gilman ...AG (Eds.), Goodman DOd Gilman’s Th(~ phannncological basls of therapeutics. lOth ed. New York: McGrow-HIII; pp. 175-191. Vallejo-Freire AA. 1951. A

  3. Preliminary Screening Procedures and Criteria for Replacements for Halons 1211 and 1301

    Science.gov (United States)

    1991-07-01

    trace quantities of bromine (Br 2), carbonyl fluoride (COF2), and carbonyl bromide ( COBr 2). The most noticeable effect of exposure to the decomposition...products are mainly HF, HCI, HBr, Cl2, Br 2, and traces of the carbonyl halides - COF2, COC 2, and COBr 2. 3. Halon 2402 [17-191 Although halon 2402 is

  4. Dicty_cDB: VSH329 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 96315 |pid:none) Auxenochlorella protothecoides rib... 191 2e-65 protein update 2..... 197 7e-66 BC054263_1( BC054263 |pid:none) Xenopus laevis hypothetical protei... 195 1e-65 FJ196315_1( FJ1

  5. 40 CFR 194.2 - Definitions.

    Science.gov (United States)

    2010-07-01

    .... Department means the United States Department of Energy. Disposal regulations means part 191, subparts B and... pursuant to section 213 of the Department of Energy National Security and Military Applications of Nuclear... operation or organization(s) to establish whether the prevailing quality management structure,...

  6. 75 FR 69892 - Final Flood Elevation Determinations

    Science.gov (United States)

    2010-11-16

    ... miles +684 City of Lexington, City upstream of U.S. Route 24. of Napoleon, City of Wellington... inspection at 919 Franklin Street, Lexington, MO 64067. ] City of Napoleon Maps are available for inspection at 191 West 2nd Street, Napoleon, MO 64074. City of Waverly Maps are available for inspection at...

  7. Land Leeches of the g.Haemadipsa (Haemadipsoidea:Haemadipsidae). II. Bibliography.

    Science.gov (United States)

    1982-05-01

    Sangsues Terrestres). Bull Soc Pathol Exot 10:640-675, 1917 10. DEQUAL, L. Nuovi Irudinei esotici del Museo Zoologico di Torino. Boll Mus Zool Anat Comp...A. Forest pests man should avoid. Philipp J For 3:191-201, 1940 DEQUAL, L. Nuovi Irudinei esotici del Museo Zoologico di Torino. BtI)i Mus Zool Anat

  8. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia

    NARCIS (Netherlands)

    I. Chumakov (Ilya); M. Blumenfeld (Marta); O. Guerassimenko (Oxana); L. Cavarec (Laurent); M. Palicio (Marta); H. Abderrahim (Hadi); L. Bougueleret (Lydie); C. Barry (Caroline); H. Tanaka (Hiroaki); P. La Rosa (Philippe); A. Puech (Anne); N. Tahri (Nadia); A. Cohen-Akenine (Annick); S. Delabrosse (Sylvain); S. Lissarrague (Sébastien); F.P. Picard; K. Maurice (Karelle); L. Essioux (Laurent); P. Millasseau (Philippe); P. Grel (Pascale); V. Debailleul (Virginie); A-M. Simon (Anne-Marie); D. Caterina (Dominique); I. Dufaure (Isabelle); K. Malekzadeh (Kattayoun); M. Belova (Maria); J.J. Luan; M. Bouillot (Michel); J.L. Sambucy; G. Primas (Gwenael); M. Saumier (Martial); N. Boubkiri (Nadia); S. Martin-Saumier (Sandrine); M. Nasroune (Myriam); H. Peixoto (Hélène); A. Delaye (Arnaud); V. Pinchot (Virginie); M. Bastucci (Mariam); S. Guillou (Sophie); M. Chevillon (Magali); R. Sainz-Fuertes (Ricardo); S. Meguenni (Said); J. Aurich-Costa (Joan); D. Cherif (Dorra); A. Gimalac (Anne); C.M. van Duijn (Cock); D. Gauvreau (Denis); G. Ouelette; I. Fortier (Isabel); J. Realson; T. Sherbatich (Tatiana); N. Riazanskaia (Nadejda); E. Rogaev (Evgeny); P. Raeymaekers (Peter); J. Aerssens (Jeroen); F. Konings (Frank); W. Luyten (Walter); F. Macciardi (Fabio); P.C. Sham (Pak); R.E. Straub (Richard); D.R. Weinberger (Daniel); N. Cohen (Nadine); D. Cohen (Daniel)

    2002-01-01

    textabstractA map of 191 single-nucleotide polymorphism (SNPs) was built across a 5-Mb segment from chromosome 13q34 that has been genetically linked to schizophrenia. DNA from 213 schizophrenic patients and 241 normal individuals from Canada were genotyped with this marker set. Two 1,400- and 65-kb

  9. A Comparison of Motivational Factors and Barriers to Physical Activity among Traditional versus Nontraditional College Students

    Science.gov (United States)

    Kulavic, Kimberly; Hultquist, Cherilyn N.; McLester, John R.

    2013-01-01

    Objective: To investigate the motivational factors and the barriers to physical activity (PA) in traditional college students (TS) and nontraditional college students (NTS) and determine if differences exist between these 2 groups. Participants: A total of 746 college students; 628 were TS (19.1 [plus-minus] 1.2 years), and 118 were NTS (31.2…

  10. Persistent angina: highly prevalent and associated with long-term anxiety, depression, low physical functioning, and quality of life in stable angina pectoris

    DEFF Research Database (Denmark)

    Jespersen, L.; Abildstrom, S. Z.; Hvelplund, Anders;

    2013-01-01

    To evaluate persistent angina in stable angina pectoris with no obstructive coronary artery disease (CAD) compared to obstructive CAD and its relation to long-term anxiety, depression, quality of life (QOL), and physical functioning. We invited 357 patients (men = 191; women = 166; response rate ...

  11. Smokeless Tobacco Consumption by Mexican-American High School Students.

    Science.gov (United States)

    Lopez, Linda C.; Hamlin, Penelope A.

    A survey of 208 female and 191 male students attending a public high school in southwestern New Mexico assessed the extent of student use of smokeless tobacco products. The sample included 179 Mexican-American and 26 Anglo-American females, as well as 152 Mexican-American and 26 Anglo-American males. The average age of both female and male…

  12. International Economic Co-operation

    NARCIS (Netherlands)

    J. Tinbergen (Jan)

    1945-01-01

    textabstractSeries ‘Elseviers Economische Bibliotheek’, No.4, Elsevier, Amsterdam, 1945, 208 p. In Spanish: La Cooperación Económica Internacional, Biblioteca de la Ciencia Económica, Madrid, 1952, 186 p. 2nd, complete revised edition, 1954, Elsevier, 191 p.

  13. Acceptability and Preliminary Outcomes of a Peer-Led Depression Prevention Intervention for African American Adolescents and Young Adults in Employment Training Programs

    Science.gov (United States)

    Tandon, Darius; Mendelson, Tamar; Mance, GiShawn

    2011-01-01

    This study examines the acceptability and preliminary outcomes from an open trial of a depression prevention intervention for low-income African American adolescents and young adults in employment training programs. The sample (N=42) consisted of predominately African American adolescents and young adults (mean age=19.1) exhibiting subclinical…

  14. ATLAS: End-cap Toroid assembly

    CERN Multimedia

    2006-01-01

    In building 191 and building 180- assembly of this massive piece.To reach the top of the end-cap the cranes has to be used and during the assembly you can see welding and hear many tools running background.

  15. 78 FR 52872 - Airworthiness Directives; 328 Support Services GmbH (Type Certificate Previously Held by AvCraft...

    Science.gov (United States)

    2013-08-27

    ... AD. Discussion On July 17, 2008, we issued AD 2008-14-16, Amendment 39-15611 (73 FR 40955, July 17... (73 FR 40955, July 17, 2008), we received reports that certain fasteners which were installed as part... $15,191 $531,685 actions from AD 2008-14-16, hour = $3230. Amendment 39-15611 (73 FR 40955, July...

  16. Data of evolutionary structure change: 1E2TG-2PFRB [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1E2TG-2PFRB 1E2T 2PFR G B HMTSFLHAYFTRLHCQPLGVPTVEALRTLHLAHNCAIPF...ine> ARG CA 539 2PFR B 2PFR...CA 191 GLN CA 212 VAL CA 236 2PFR B 2PFRB RKFNYKDNTDLVEFK 2.972101926803589 2 2PFR<

  17. Proceedings of the Fourth International Symposium on Quantum Confinement: Nanoscale Materials, Devices, and Systems Proceedings, Volume 97-11

    Science.gov (United States)

    1997-11-04

    and Systems, held May 4-7 in Montreal, Canada, as part of the 191st Meeting of the Electrochemical Society . The symposium was sponsored by the...Dielectric Science and Technology, the Electronics, and the Luminescence and Display Materials divisions of the Electrochemical Society . The symposium was

  18. New floristic records in the Balkans: 3

    DEFF Research Database (Denmark)

    2006-01-01

    ), Plantaginaceae (122), Poaceae (69-70, 108, 115, 116, 127), Polygalaceae (183), Polygonaceae (55), Pyrolaceae (184), Ranunculaceae (11, 83, 84, 113, 123, 185), Rhamnaceae (56), Rosaceae (130, 186-189, 222), Rubiaceae (57, 190, 223-225), Salicaceae (58), Salviniaceae (98), Santalaceae (191), Sapindaceae (243...

  19. Evaluation and Analyses of Cultural Diversity Training with Environmental Educators

    Science.gov (United States)

    Galvan, Alma R.; LaRocque, Lisa

    2010-01-01

    The Environmental Education and Training Partnership Cultural Diversity Workshops were based on theoretical models and designed to increase individuals' awareness, knowledge, and intentions toward increasing culturally sensitivity. This study reports on the evaluation results from 191 participants. Their responses indicate significant changes in…

  20. A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

    NARCIS (Netherlands)

    Wu, Xifeng; Scelo, Ghislaine; Purdue, Mark P.; Rothman, Nathaniel; Johansson, Mattias; Ye, Yuanqing; Wang, Zhaoming; Zelenika, Diana; Moore, Lee E.; Wood, Christopher G.; Prokhortchouk, Egor; Gaborieau, Valerie; Jacobs, Kevin B.; Chow, Wong-Ho; Toro, Jorge R.; Zaridze, David; Lin, Jie; Lubinski, Jan; Trubicka, Joanna; Szeszenia-Dabrowska, Neonilia; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Mates, Dana; Jinga, Viorel; Bencko, Vladimir; Slamova, Alena; Holcatova, Ivana; Navratilova, Marie; Janout, Vladimir; Boffetta, Paolo; Colt, Joanne S.; Davis, Faith G.; Schwartz, Kendra L.; Banks, Rosamonde E.; Selby, Peter J.; Harnden, Patricia; Berg, Christine D.; Hsing, Ann W.; Grubb, Robert L.; Boeing, Heiner; Vineis, Paolo; Clavel-Chapelon, Francoise; Palli, Domenico; Tumino, Rosario; Krogh, Vittorio; Panico, Salvatore; Duell, Eric J.; Ramon Quiros, Jose; Sanchez, Maria-Jose; Navarro, Carmen; Ardanaz, Eva; Dorronsoro, Miren; Khaw, Kay-Tee; Allen, Naomi E.; Bueno-de-Mesquita, H. Bas; Peeters, Petra H. M.; Trichopoulos, Dimitrios; Linseisen, Jakob; Ljungberg, Borje; Overvad, Kim; Tjonneland, Anne; Romieu, Isabelle; Riboli, Elio; Stevens, Victoria L.; Thun, Michael J.; Diver, W. Ryan; Gapstur, Susan M.; Pharoah, Paul D.; Easton, Douglas F.; Albanes, Demetrius; Virtamo, Jarmo; Vatten, Lars; Hveem, Kristian; Fletcher, Tony; Koppova, Kvetoslava; Cussenot, Olivier; Cancel-Tassin, Geraldine; Benhamou, Simone; Hildebrandt, Michelle A.; Pu, Xia; Foglio, Mario; Lechner, Doris; Hutchinson, Amy; Yeager, Meredith; Fraumeni, Joseph F.; Lathrop, Mark; Skryabin, Konstantin G.; McKay, James D.; Gu, Jian; Brennan, Paul; Chanock, Stephen J.

    2012-01-01

    Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional RCC common susceptibility loci, we conducted an independent genome- wide association study (GWAS). We analyzed 533 191 single nucleotide poly

  1. 46 CFR 160.077-5 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ... ASTM D 751-95, Standard Test Methods for Coated Fabrics—160.077-19 ASTM D 1434-82 (1988), Standard Test... Standards In Federal Test Method Standard No. 191 the following test methods: (1) Method 5100, Strength and... (NBS) “The Universal Color Language” and “The Color Names Dictionary” in Color: Universal Language...

  2. Identifying Alternative Conceptions of Chemical Kinetics among Secondary School and Undergraduate Students in Turkey

    Science.gov (United States)

    Cakmakci, Gultekin

    2010-01-01

    This study identifies some alternative conceptions of chemical kinetics held by secondary school and undergraduate students (N = 191) in Turkey. Undergraduate students who participated are studying to become chemistry teachers when they graduate. Students' conceptions about chemical kinetics were elicited through a series of written tasks and…

  3. The Skills Enhancement Training Program. Performance Report.

    Science.gov (United States)

    Food and Beverage Workers Union, Local 32, Washington, DC.

    This report describes a joint labor-management workplace literacy program called SET (Skills Enhancement Training) that targeted the more than 2,000 unionized employees of food service contractors at U.S. government institutions in Washington, D.C. Nineteen classes were offered and a total of 191 people self-selected themselves into the program.…

  4. Delineation of Behavioral Phenotypes in Genetic Syndromes: Characteristics of Autism Spectrum Disorder, Affect and Hyperactivity

    Science.gov (United States)

    Oliver, Chris; Berg, Katy; Moss, Jo; Arron, Kate; Burbidge, Cheryl

    2011-01-01

    We investigated autism spectrum disorder (ASD) symptomatology, hyperactivity and affect in seven genetic syndromes; Angelman (AS; n = 104), Cri du Chat (CdCS; 58), Cornelia de Lange (CdLS; 101), Fragile X (FXS; 191), Prader-Willi (PWS; 189), Smith-Magenis (SMS; 42) and Lowe (LS; 56) syndromes (age range 4-51). ASD symptomatology was heightened in…

  5. Invisible Wounds of War. Summary and Recommendations for Addressing Psychological and Cognitive Injuries

    Science.gov (United States)

    2008-01-01

    advice throughout this project. We thank LTC David Benedek , Howard Goldman, Cathy Sherbourne, LTG Ronald Blanck (Ret.), Thomas Garthwaite, and Carole...www.rand.org/pubs/monographs/MG191/ Hoge, C. W., S. E. Lesikar, R. Guevara, J. Lange , J. F. Brundage, Jr., C. C. Engel, S. C. Messer, and D. T. Orman

  6. Epitrochoid Power-law Nozzle Concept for Reducing Launch Architecture Propulsion Costs

    Science.gov (United States)

    2010-11-16

    Merlin 1 C vacuum engine c. Energia booster RD-170-7Zenit RO-171-7Atlas V RD-180-7Angara RO-191 4. Develop a new propulsion system to incorporate...the four liquid boosters of the Energia launch vehicle designed to launch the Soviet Buran space shuttle. In parallel with the Buran development, a

  7. Effect of pressure on f-electron delocalization and oxidation in actinide dioxides

    Energy Technology Data Exchange (ETDEWEB)

    Petit, Leon [Daresbury Laboratory, UK; Szotek, Zdzislawa [Daresbury Laboratory, UK; Temmerman, Walter M [Daresbury Laboratory, UK; Stocks, George Malcolm [ORNL; Svane, Axel [University of Aarhus, Denmark

    2014-08-01

    Using rstprinciplescalculations,wehaveinvestigatedf-electrondelocalizationandoxidationintheactinidedioxidesunderpressure.WhilstUO2isfoundonthevergeofaninsulatortometaltransitionattheequilibriumvolume,increasinglylargerpressuresarerequiredtodelocalizef-electronsinNpO2,PuO2,andAmO2,respectively49,112,and191GPa.Comparedtothisbroadrangeofpressures,theexper-imentallyobservedstructuraltransitions,inallfourdioxides,occurbetween30and40GPa,whichleadsustoconcludethattheassociatedvolumecollapseisnotduetof-electrondelocalization.Incontrast,oxi-dationofthedioxidesisfoundtobelinkedtothedegreeoff-electronlocalization,butitemergesthatfornaturallyoccurringpressures(<10GPa),higheroxidesonlyexistforUO2.

  8. 40 CFR 1065.260 - Flame-ionization detector.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Flame-ionization detector. 1065.260 Section 1065.260 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION... emissions at a temperature of (191 ± 11) °C. (d) FID fuel and burner air. Use FID fuel and burner air...

  9. Self-assessed tactical skills in elite youth soccer players : a longitudinal study

    NARCIS (Netherlands)

    Kannekens, R.; Elferink-Gemser, M. T.; Post, W. J.; Visscher, C.

    2009-01-01

    Self-assessed tactical skills were investigated among 191 Youth soccer players from ages 14 through 18 playing in different field positions. On a yearly basis, all players completed the Tactical Skills Inventory for Sports with scales for attacking and defensive situations and for declarative and pr

  10. Item Construction and Psychometric Models Appropriate for Constructed Responses

    Science.gov (United States)

    1991-08-01

    Satistics Universit of Illinois Newtowns. PA 191W00 101 Ilin Hall Depar-n of Paycl-loV 725 Soth Wright SL. 603 E. Daniel SL. Dr. Arne Beland Chaimpaign...Schorr AFOSRANL Bldg, 410 Pqeoloica* &Quantitative Bolling, AFM DC =033.44W Dr. Ronald A. Weawanm Foundations Box 146 Coiqe of Educaion Dr IKiktUei TaSUo

  11. Factors influencing the distribution of the Aruban whiptail lizard, Cnemidophorus arubensis

    NARCIS (Netherlands)

    Schall, Jos.J.

    1975-01-01

    Aruba, Netherlands Antilles, is a 175 km² xeric island lying off the Caribbean coast of Venezuela. The flat coral and limestone regions of the shore contrast with the rolling hills that rise in the east to elevations of 188 meters. Vegetation types are varied. The island has excellent maps (LENS 191

  12. 78 FR 6202 - Airworthiness Directives; the Boeing Company

    Science.gov (United States)

    2013-01-30

    ...-191-AD; Amendment 39-17326; AD 2013-02-05] RIN 2120-AA64 Airworthiness Directives; the Boeing Company... airworthiness directive (AD) for certain The Boeing Company Model 737-600, -700, -700C, -800, -900, and -900ER...): 2013-02-05 The Boeing Company: Amendment 39-17326; Docket No. FAA-2011-0258; Directorate...

  13. Antiviral combination therapy in chronic hepatitis B

    NARCIS (Netherlands)

    R.A. de Man (Robert)

    1990-01-01

    textabstractAn outbreak of parenterally transmitted hepatitis was probably first recorded in 1885 by Lurman who reported the occurrence of jaundice among personnel of a Bremen factory after revaccination against smallpox. Of 1289 individuals vaccinated in one day, 191 developed jaundice 2 to 8 month

  14. NCEL (Naval Civil Engineering Lab.) Ocean Platforms Seminar.

    Science.gov (United States)

    1983-11-01

    type platforms. Both Cerveza and the Cerveza Ligera platforms[ 7] were launched in one piece and installed in 935 ft and 925 ft of water respectively...6. Magnus Jacket Takes Heavy Honors, Offshore V 42, No. 5, pp 189, 191- 193, May 1982. 7. Tannahill, C. A, W. M. Isenhower, D. D. Engle, Cerveza - A

  15. EST Table: BJ984640 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BJ984640 E_FL_mxg-_13B02_F_0 10/09/28 99 %/219 aa ref|NP_001103794.1| calcyphosphine... isoform 1 [Bombyx mori] gb|ABF51310.1| calcyphosphine isoform 1 [Bombyx mori] 10/08/28 57 %/191 aa FBpp017

  16. Area Handbook Series. Somalia: A Country Study

    Science.gov (United States)

    1992-05-01

    Semitic languages of Arabic, Hebrew, and Amharic . Medieval Arabs referred to the Eastern Cushites as the Berberi. In addition to the Somalis, the Cushites...36, 46, 191 Amharic : broadcasts in, 171 Abu Dhabi: debt to, 130 Amministrzioe Fiduciaria Italiana della Adal, 6-8 Somalia. See Trusteeship Administra

  17. File list: ALL.Lng.05.AllAg.Fetal_lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Lng.05.AllAg.Fetal_lung hg19 All antigens Lung Fetal lung SRX031381,SRX031423,S...191,SRX055187,SRX055198,SRX031384,SRX041015,SRX056806,SRX056804,SRX056805 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Lng.05.AllAg.Fetal_lung.bed ...

  18. Rites of Passage: A Comparison of US, Malaysian and Brazilian Adolescents

    Science.gov (United States)

    McCarthy, Sherri Nevada; de Souza, Luciana Karine; Jafaar, Jas

    2010-01-01

    This study compares the life events perceived as "rites of passage" from adolescence to adulthood by respondents between the ages of 14 and 23 in 3 countries and discusses the possible influences of culture and globalization on these perceptions. Participants include: (1) 250 adolescents from the US (125 males and 125 females); (2) 191

  19. [Book review] Epiphytic Lichen Diversity and its Dependence on Chemical Site Factors in Differently Elevated Dieback-affected Spruce Stands of the Harz Mountains, by Volker Hesse

    Science.gov (United States)

    Bennett, J.P.

    2002-01-01

    Review of: Epiphytic lichen diversity and its dependence on chemical site factors in differently elevated dieback-affected spruce stands of the Harz Mountains. (Dissertationes Botanicae, Band 354). Volker Hesse. 2002. 191 pages, 66 figures, 49 tables, 23x14cm, 390 g. ISBN 978-3-443-64266-2.

  20. Foster Parents' Involvement in Authoritative Parenting and Interest in Future Parenting Training

    Science.gov (United States)

    King, Keith A.; Kraemer, Linda K.; Bernard, Amy L.; Vidourek, Rebecca A.

    2007-01-01

    We surveyed 191 Southwest Ohio foster parents regarding their involvement in authoritative parenting and interest for additional parenting education. Our results showed that most respondents reported using an authoritative parenting style and were interested in receiving future training. Involvement in authoritative parenting differed…