WorldWideScience

Sample records for astatine 191

  1. Organic chemistry of astatine

    International Nuclear Information System (INIS)

    The paper surveys the investigations on the chemical behaviour of astatine in organic systems and deals with the preparation and identification of its organic compounds. A discussion is given on some of the physico-chemical properties of these compounds determined by extrapolation techniques as well as by direct measurement. The biomedical importance of 211At-labelled compounds is briefly referred to. (authors)

  2. Bibliography of astatine chemistry and biomedical applications

    International Nuclear Information System (INIS)

    An overall bibliography is presented on astatine chemistry and on the biomedical applications of its 211At isotope. The references were grouped in the following chapters: General reviews; Discovery, Natural Occurence; Nuclear Data; Preparation, Handling, Radiation Risk; Physico-chemical Properties; Astatine Compounds and Chemical Reactions; Biological Effects and Applications. Entries are sorted alphabetically by authors name in each chapter, and cross-references to other chapters are provided if appropriate. (R.P.)

  3. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production. PMID:22201707

  4. Recent advances in the organic chemistry of astatine

    International Nuclear Information System (INIS)

    Investigation on the chemical behaviour of astatine in the last decade are surveyed. The survey covers the physical and chemical properties of astatine, synthesis and identification of organic astatine compounds, their physicochemical properties. A special chapter is devoted to biomedical applications, including inorganic 211At species, 211At-labelled proteins and drugs. An extensive bibliography of the related literature is given. (N.T.) 129 refs.; 12 figs.; 14 tabs

  5. Dosimetrical considerations in astatine-211 radioimmunotherapy

    International Nuclear Information System (INIS)

    Several dosimetrical quantities have been suggested for use in alpha-particle dosimetry. To evaluate the expected biological effect when using these quantities, a Monte Carlo program was set to register the single-event distribution of both specific energy and alpha-particle track length to a cell nucleus (r=5.6 μm). Distributions were acquired for both 'bound' (simulating the effect of 211At-labelled antibodies bound to antigens on cell surfaces (r=7.0 μm)) as well as 'non-bound' (simulating 211At-labelled antibodies that have not bound to a cell) astatine-211. From these distributions, various theoretical cell survival curves were established for 3 different dosimetrical quantities, i.e. specific energy, number of alpha-particle hits and total track length. The survival curves for all quantities are presented for the corresponding mean absorbed dose in order to facilitate comparisons of the expected effects of using the 3 different quantities for both distributions of 211At decays. The theoretical survival curves presented here could, combined with experiments using 'bound' and 'non-bound' 211At in a single-cell suspension, reveal which dosimetrical quantity is most suitable for 211 At-radioimmunotherapy. (author)

  6. Discovery of the astatine, radon, francium, and radium isotopes

    OpenAIRE

    Fry, C; Thoennessen, M

    2012-01-01

    Currently, thirty-nine astatine, thirty-nine radon, thirty-five francium, and thirty-four radium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  7. Extraction of astatine isotopes for development of radiopharmaceuticals using a 211Rn-211At generator

    International Nuclear Information System (INIS)

    In order to utilize a 211At isotope, a promising α-emitter for radionuclide therapy, the chemical properties of astatine isotopes are studied. We have examined wet chemistry methods through the distribution ratios of astatine in liquid-liquid extraction. The astatine isotopes have been found to be well extracted into DIPE and MIBK. We observed that the distribution ratio of astatine isotopes increases with concentrations of HCl greater than 3 M, while it decreases with the HCl concentration less than 2 M. The results will be useful for development of the 211Rn-211At generator. (author)

  8. Astatine-211-Labeled Targeted Radiotherapeutics: An Update

    International Nuclear Information System (INIS)

    The heavy halogen 211At was first proposed for use in α-particle targeted radiotherapy more than 30 years ago and continues to be one of the most promising radionuclides for this purpose. Although its 7.2-h half life is not ideal for intravenously administered whole antibodies, it is compatible with the pharmacokinetics of antibody fragments, peptides, aptamers and organic molecules. Its diverse chemistry allows its incorporation into a wide array of targeting vehicles, relying on its chemical similarity to iodine to provide a useful point of departure. On the other hand, the relatively low carbon-astatine bond strength is challenging. In common with the other α-emitters being discussed at this symposium, lack of reliable availability is one of the biggest hurdles in the use of 211At for targeted radiotherapy. However, in the case of 211At, it is not a question of production cost or availability of target material, because 211At can be produced in reasonable yield from natural bismuth targets. Rather, the difficulty is the lack of cyclotrons equipped with the medium energy α-particle beams required for its production. If the infrastructure for producing 211At is to be improved to the stage where 211At-labeled radiopharmaceuticals can have a meaningful impact, several developments must occur. First, the ability to produce clinically relevant levels of 211At that can be shipped to remote locations in chemically tractable form must be demonstrated. Approaches under consideration include compensating for radiolysis-mediated effects and the consideration of alternative chemistries. Second, strategies for compensating for heterogeneities in dose deposition must be developed, hopefully in a way that is compatible with approval for human use. And third, it is essential that more clinical trials be performed with 211At-labeled therapeutics, particularly in settings of minimum residual disease where the radiobiological advantages of α-particles can be best exploited. Our

  9. Scrutinizing "Invisible" astatine: A challenge for modern density functionals.

    Science.gov (United States)

    Sergentu, Dumitru-Claudiu; David, Grégoire; Montavon, Gilles; Maurice, Rémi; Galland, Nicolas

    2016-06-01

    The main-group 6p elements did not receive much attention in the development of recent density functionals. In many cases it is still difficult to choose among the modern ones a relevant functional for various applications. Here, we illustrate the case of astatine species (At, Z = 85) and we report the first, and quite complete, benchmark study on several properties concerning such species. Insights on geometries, transition energies and thermodynamic properties of a set of 19 astatine species, for which reference experimental or theoretical data has been reported, are obtained with relativistic (two-component) density functional theory calculations. An extensive set of widely used functionals is employed. The hybrid meta-generalized gradient approximation (meta-GGA) PW6B95 functional is overall the best choice. It is worth noting that the range-separated HSE06 functional as well as the old and very popular B3LYP and PBE0 hybrid-GGAs appear to perform quite well too. Moreover, we found that astatine chemistry in solution can accurately be predicted using implicit solvent models, provided that specific parameters are used to build At cavities. © 2016 Wiley Periodicals, Inc. PMID:27059181

  10. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  11. Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

    Science.gov (United States)

    Aneheim, Emma; Gustafsson, Anna; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Svedhem, Sofia; Lindegren, Sture

    2016-03-16

    Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult cancers in the form of microtumors or even single cancer cells. A promising radioactive nuclide for this type of therapy is astatine-211. Astatine-211 attached to tumor-specific antibodies as carrier molecules is a system currently under investigation for use in targeted alpha therapy. In the common radiolabeling procedure, astatine is coupled to the antibody arbitrarily on lysine residues. By instead coupling astatine to disulfide bridges in the antibody structure, the immunoreactivity of the antibody conjugates could possibly be increased. Here, the disulfide-based conjugation was performed using a new coupling reagent, maleimidoethyl 3-(trimethylstannyl)benzamide (MSB), and evaluated for chemical stability in vitro. The immunoconjugates were subsequently astatinated, resulting in both high radiochemical yield and high specific activity. The MSB-conjugate was shown to be stable with a long shelf life prior to the astatination. In a comparison of the in vivo distribution of the new immunoconjugate with other tin-based immunoconjugates in tumor-bearing mice, the MSB conjugation method was found to be a viable option for successful astatine labeling of different monoclonal antibodies. PMID:26791409

  12. 19 CFR 191.93 - Combined applications.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Combined applications. 191.93 Section 191.93... § 191.93 Combined applications. An applicant for the procedures provided for in §§ 191.91 and 191.92 of... application package (see also § 191.195 of this part regarding combined applications for certification in...

  13. Astatine-211: production, injection into monoclonal antibodies radiological effect, possible application to cancer treatment

    International Nuclear Information System (INIS)

    Methods developed in the Laboratory of Nuclear Problems, JINR, for producing astatine-211 and injecting it into monoclonal antibodies are described. The use of its diethylene triamine penta-acetic acid complex is shown to be the most effective method of injecting astatine into a biomolecules. The biological effect of the α-particles emitted from the astatine-211 is investigated using Chinese hamster fibroblasts and Ehrlich carcinoma cells. It is established that the mitotic activity depression, number of degenerating cells, number of cells with chromosome aberrations, and cellular surviving fraction depend on the concentration of the radionuclide in the medium 'in vitro'. The RBE of α-particles in comparison with 60Co γ-rays is 3. Injection of astatine-211 absorbed on tellurium particles into mice with ascitic tumors resulted in prolongation of their life or elimination of the tumors. (author). 39 refs, 7 figs

  14. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    OpenAIRE

    Rothe, S.; A. N. Andreyev; Antalic, S; Borschevsky, A.; Capponi, L.; Cocolios, T.E.; Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the io...

  15. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    Science.gov (United States)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-07-01

    To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method that combines dry distillation of astatine-211 and a synthesis module for producing radiopharmaceuticals into a process platform. This platform will standardize production of astatinated radiopharmaceuticals, and hence, it will facilitate large clinical studies focused on this promising, but chemically challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies.

  16. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom; Jensen, Holger; Palm, Stig; Lindegren, Sture

    2015-01-01

    vector, which can guide the radiation to the cancer cells. Consequently, an appropriate method is required for coupling the nuclide to the vector. To increase the availability of astatine-211 radiopharmaceuticals for targeted alpha therapy, their production should be automated. Here, we present a method......To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical and...... challenging, alpha-emitting radionuclide. In this work, we describe the process platform, and we demonstrate the production of both astaine-211, for preclinical use, and astatine-211 labelled antibodies....

  17. Study of Astatine (III) reactions with O, S and N ligands in solution

    International Nuclear Information System (INIS)

    Full text of publication follows. Astatine (At, Z=85: [Xe]4f145d106s26p5) belongs to the halogen group and is located below iodine in the periodic table. One of its isotopes (211At) appears promising as a therapeutic agent in nuclear medicine (Ref.1) owing to the energy of the alpha particles emitted during the disintegration of its nucleus and its short physical half-life (7.2 h). Since there are no stable isotopes of astatine, the chemistry of this element remains poorly understood. Generally, At is supposed to behave as a halogen (Ref.2) but it has been shown recently in our group that astatine presents a metallic behaviour in aqueous solution: it notably exists as At+ and AtO+ species under the oxidation states +I and +III (Ref.3). At the present time, the number of studies dealing with the complexation properties of the cationic forms of astatine remains limited (Ref.4), owing to its low availability. In this work, we have investigated the reactions of AtO+ species with different hetero-atomic (N, S, O) model ligands. A combined approach based on experimental and theoretical studies has been used (Ref.5). On account of the difficulties of experimental investigations of astatine species, the reactivity of AtO+ was explored using a competition method founded on astatine distributions between two distinct phases. Furthermore, for each AtO+/ ligand complex, the nature of the species formed and the associated thermodynamic constants were determined by computational modeling (DFT calculations). In this framework, an original computational methodology was developed to take into account the specificities of astatine, notably the associated relativistic effects. The computed equilibrium constants have been confronted with the experimental results. This comparison demonstrates an outstanding coherence between experience and theory. Furthermore, the analysis of the results shows a key role of solvent effects on astatine chemistry. Lastly, a specific reactivity for the

  18. The decay of 191Os

    International Nuclear Information System (INIS)

    Gamma ray and conversion electron energies and intensities for transitions in 191Ir have been measured in the decay of 191Os using a Ge(Li) detector and a double focusing beta spectrometer. The following energies (in keV) and transition multipolarities were found: 41.92 ± 0.02 (E3), 47.05 ± 0.03 (E2), 82.46 ± 0.04 (56% M1 + 44% E2) and 129.52 + 0.02 (88% M1 + 12% E2). From a delayed coincidence measurement the half-life of the 129.52 keV level in 191Ir was found to be (1.26 ± 0.11) x 10-10 sec

  19. Some aspects of the organic, biological and inorganic chemistry of astatine

    International Nuclear Information System (INIS)

    Astatine has no stable isotopes and the radioactive isotopes with half-lives sufficiently long for chemical experiments (209At, 210At, 211At) must be produced artificially with a cyclotron or with a high energy accelerator by spallation of Th. This thesis deals with the synthesis and chemistry of At-compounds and the determination of some of their properties. (C.F.)

  20. 32 CFR 191.4 - Policy.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Policy. 191.4 Section 191.4 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS THE DOD CIVILIAN EQUAL EMPLOYMENT OPPORTUNITY (EEO) PROGRAM § 191.4 Policy. It is DoD Policy to: (a)...

  1. 19 CFR 191.163 - Documentation.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Documentation. 191.163 Section 191.163 Customs... or Specifications § 191.163 Documentation. (a) Entry. Customs Form 7551 shall be used to claim drawback under this subpart. (b) Documentation. The drawback entry for unmerchantable merchandise shall...

  2. 40 CFR 191.03 - Standards.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Standards. 191.03 Section 191.03... ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR MANAGEMENT AND DISPOSAL OF SPENT NUCLEAR FUEL, HIGH-LEVEL AND TRANSURANIC RADIOACTIVE WASTES Environmental Standards for Management and Storage § 191.03 Standards....

  3. 32 CFR 191.5 - Responsibilities.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 191.5 Section 191.5 National... DOD CIVILIAN EQUAL EMPLOYMENT OPPORTUNITY (EEO) PROGRAM § 191.5 Responsibilities. (a) The Assistant... responsibilities. (7) Ensure fair, impartial, and timely investigation and resolution of complaints...

  4. 22 CFR 191.21 - Applicable benefits.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Applicable benefits. 191.21 Section 191.21 Foreign Relations DEPARTMENT OF STATE HOSTAGE RELIEF HOSTAGE RELIEF ASSISTANCE Medical Benefits § 191.21 Applicable benefits. A person eligible for benefits under this part shall be eligible for authorized...

  5. 22 CFR 191.11 - Applicable benefits.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Applicable benefits. 191.11 Section 191.11...' and Sailors' Civil Relief Act § 191.11 Applicable benefits. (a) Eligible persons are entitled to the benefits provided by the Soldiers' and Sailors' Civil Relief Act of 1940 (50 U.S.C. App. 501, et...

  6. 19 CFR 191.13 - Packaging materials.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Packaging materials. 191.13 Section 191.13 Customs... (CONTINUED) DRAWBACK General Provisions § 191.13 Packaging materials. (a) Imported packaging material... packaging material when used to package or repackage merchandise or articles exported or destroyed...

  7. 40 CFR 191.13 - Containment requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Containment requirements. 191.13 Section 191.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION..., HIGH-LEVEL AND TRANSURANIC RADIOACTIVE WASTES Environmental Standards for Disposal § 191.13...

  8. 19 CFR 191.84 - Protests.

    Science.gov (United States)

    2010-04-01

    ...) DRAWBACK Liquidation and Protest of Drawback Entries § 191.84 Protests. Procedures to protest the denial, in whole or in part, of a drawback entry shall be in accordance with part 174 of this chapter (19 CFR... 19 Customs Duties 2 2010-04-01 2010-04-01 false Protests. 191.84 Section 191.84 Customs Duties...

  9. Astatine-211 Pathway from Radiochemistry to Clinical Investigation

    International Nuclear Information System (INIS)

    Particularly in clinical settings where tumour burden is low and cancers are located in close proximity to essential normal tissue structures, α-particle emitting radionuclides can offer significant advantages for targeted radionuclide therapy. One of the first alpha emitters to be evaluated for this purpose is the 7.2-h half-life radiohalogen Astatine-211 (211At). From a commercialization-potential perspective 211At, is less appealing than the longer half-life alpha particle emitters Radium-223, Actinium-225 and Thorium-227, which have become the focus of many laboratories. However, if methods for providing a better supply of 211At could be developed, this alpha emitter would be the radionuclide of choice for many potential therapeutic applications. With regard to the production of 211At, this can be readily be accomplished by bombarding natural bismuth targets with 28−29.5 MeV alpha particles via the 209Bi(α,2n)211At reaction. The goal is to utilize an alpha particle beam energy that provides the required balance for maximizing 211At production while minimizing creation of 210At, which is problematic because of its 138.4-day half life alpha-particle emitting daughter, 210Po. For most intended clinical applications, alpha particle beam energy of about 29 MeV offers the best compromise between maximizing yield and providing 211At with sufficient radionuclidic purity for clinical use. Clinically relevant levels of 211At have been produced at several institutions using both internal and external cyclotron targets

  10. Dicty_cDB: SLA191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLA191 (Link to dictyBase) - - - Contig-U16523-1 SLA191Z (Link... to Original site) - - SLA191Z 561 - - - - Show SLA191 Library SL (Link to library) Clone ID SLA191 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLA1-D/SLA191Q.Seq.d/ Representative seq. ID SLA19...1Z (Link to Original site) Representative DNA sequence >SLA191 (SLA191Q) /CSM/SL/SLA1-D/SLA191Q.Seq.d/ XXXXX...TATTTACCAATTGTTAAAACTCATTTTATTTTATTTTTATCTCTTACATATCTCTTT TTCTATTAATAATAAAAATAATAATATTACA sequence update 1997. 5.16 Transla

  11. An attempt to explore the production routes of Astatine radionuclides: Theoretical approach

    OpenAIRE

    Maiti, Moumita; Lahiri, Susanta

    2008-01-01

    In order to fulfil the recent thrust of Astatine radionuclides in the field of nuclear medicine various production routes have been explored in the present work. The possible production routes of $^{209-211}$At comprise both light and heavy ion induced reactions at the bombarding energy range starting from threshold to maximum 100 MeV energy. For this purpose, we have used the nuclear reaction model codes TALYS, ALICE91 and PACE-II. Excitation functions of those radionuclides, produced throug...

  12. 27 CFR 20.191 - Bulk articles.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bulk articles. 20.191... Users of Specially Denatured Spirits Operations by Users § 20.191 Bulk articles. Users who convey articles in containers exceeding one gallon may provide the recipient with a photocopy of subpart G of...

  13. 40 CFR 436.191 - Specialized definitions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Specialized definitions. 436.191 Section 436.191 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS MINERAL MINING AND PROCESSING POINT SOURCE CATEGORY Frasch Sulfur Subcategory §...

  14. 21 CFR 155.191 - Tomato concentrates.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Tomato concentrates. 155.191 Section 155.191 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CANNED VEGETABLES Requirements for Specific Standardized Canned Vegetables §...

  15. Direct astatination of a tumour-binding protein, human epidermal growth factor, using nido-carborane as a prosthetic group

    International Nuclear Information System (INIS)

    A method for direct astatine labeling of proteins has been investigated. Binding sites for astatine were created by coupling of a nido-carborane derivative to a protein, the human epidermal growth factor (hEGF), using two different conjugation methods - by glutaraldehyde cross-linking or by introduction of sulfohydryl groups by Traut's reagent with subsequent linking of ANC-1 with m-maleimidobenzoyl-N-hydroxysulfosuccinimide ester. The conjugates were astatinated using the Chloramine-T method in high yield. The best labeling was obtained by the glutaraldehyde conjugate with an average yield of 68 ± 9%. In vitro stability tests indicated that the glutaraldehyde conjugated label was as stable as hEGF labeled with astatobenzoate. (author)

  16. Development of a new osmium-191: Iridium-191m radionuclide generator: Final report

    International Nuclear Information System (INIS)

    The use of iridium-191m (T/sub 1/2/ = 5s) for first-pass radionuclide angiography offers the potential advantages of lower patient radiation dose and the ability to obtain repeated studies without interference from the previously administered radioisotope. These potential advantages have been offset by the absence of satisfactory 191Os-/sup 191m/Ir generators. The goal of this project was, therefore, the development of an 191Os-/sup 191m/Ir generator that would be suitable for clinical use. This goal was first sought through modifications of an existing 191Os-/sup 191m/Ir generator design (i.e., changes in the ion exchange material and eluent) but these changes did not lead to the required improvements. A new approach was then undertaken in which different chemical forms of the 191Os parent were evaluated in prototype generators. The complex trans-dioxobisoxalatoosmate (VI) led to a generator with higher /sup 191m/Ir yield (25 to 30%/mL) and lower 191Os breakthrough (-4%) with a more physiologically compatible eluent than had been previously achieved. Toxicity studies were conducted on the eluate and an IND subsequently obtained. While this is not a final solution to the problem of developing a clinically acceptable 191Os-/sup 191m/Ir generator, the ''oxalate'' generator is the most significant improvement of the 191Os-/sup 191m/Ir generator to date and will be used in an expanded program of clinical studies. 16 refs., 16 tabs

  17. Dicty_cDB: AFM191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AF (Link to library) AFM191 (Link to dictyBase) - - - - AFM191P (Link to Original site) AFM191F 623 AFM...191Z 747 AFM191P 1350 - - Show AFM191 Library AF (Link to library) Clone ID AFM191 (Link... to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/AF/AFM...1-D/AFM191Q.Seq.d/ Representative seq. ID AFM191P (Link to... Original site) Representative DNA sequence >AFM191 (AFM191Q) /CSM/AF/AFM1-D/AFM191Q.Seq.d/ ATTTTCTATTTTCTTT

  18. Osmium-191/iridium-191m radionuclide generator using an oxalato osmate parent complex

    International Nuclear Information System (INIS)

    A new osmium-191/iridium-191m (191Os/191mIr) radionuclide generator has been developed that offers high 191mIr yield (greater than 20%/ml) and low 191Os breakthrough (less than 5 X 10(-4)%/ml) when eluted with a solution of 0.001 M oxalic acid and 0.9% (normal) saline. This is the first 191Os/191mIr generator that combines the advantages of high 191mIr yield, extremely low 191Os breakthrough, and an eluate that does not require buffering prior to injection. These improvements in performance were accomplished through use of the chelate transdioxobisoxalatoosmate(VI) as the parent complex on the generator. The clinical result of the combination of higher yield and lower breakthrough is a 100-fold decrease in the estimated patient radiation dose compared with the same study performed with technetium-99m (/sup 99m/Tc), and the injectable eluate makes the generator easier to use. Acute and subacute toxicity studies performed on this generator eluate have shown no adverse effects attributable to the eluate

  19. Dicty_cDB: SSA191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSA191 (Link to dictyBase) - G00581 DDB0191101 Contig-U16278-1 SSA...191E (Link to Original site) - - - - - - SSA191E 743 Show SSA191 Library SS (Link to library) Clone ID SSA...riginal site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/SS/SSA1-D/SSA191Q.Seq.d/ ...Representative seq. ID SSA191E (Link to Original site) Representative DNA sequence >SSA191 (SSA191Q) /CSM/SS/SSA1-D/SSA...lue SSC884 (SSC884Q) /CSM/SS/SSC8-D/SSC884Q.Seq.d/ 1273 0.0 SSA191 (SSA191Q) /CSM/SS/SSA1-D/SSA191Q.Seq.d/ 1

  20. Labelling prospects of astatine-211 with immunoglobulins (IgG): some general considerations

    International Nuclear Information System (INIS)

    The tumour therapeutic potential of the short lived alpha emitting radiohalogen 211At has been already been well recognised in the field of radioimmuno therapy. There is no evidence as such to show that astatine itself is a tumour seeking isotope. Therefore it has to be tagged to tumour seeking compound such as a drug or a protein preferably an antibody (IgG). In this communication, the labelling parameters which are required to be investigated for obtaining a stable product which could be useful as radioimmuno therapeutic agent, are described. (author). 6 refs

  1. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron anity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photodetachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral linewidth of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in o-line tests by the clear observation of the photodetachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148 [1].

  2. Development and clinical application of the Os-191 → Ir-191m generator

    International Nuclear Information System (INIS)

    An osmium-191 → iridium-191m generator that can deliver multiple doses of Ir-191m for first-pass radionuclide angiography has been developed. The Os-191 is loaded on an anion exchange column (AGMP-1) and Ir-191m eluted with 0.9% NaCl at pH 1. Each elution (0.6 to 1 ml) of the generator yields about 7 to 10% Ir-191m and gives 0.003 to 0.005% of Os-191 breakthrough. Toxicity studies of the generator eluate carried out in animals support the safety of using iridium-191m in humans. This new 0s-Ir generator system has been approved for human use at Children's Hospital Medical Center. This radionuclide generator was used to obtain angiogram in 94 patients. In twelve patients who underwent Ir-191m angiography and cardiac catheterization simultaneously, there was good correlation coefficient in the measurement of pulmonary to systemic flow ratio

  3. Extraction of 211At-astatine from hydrochloric acid solutions by means of TOPO, TBP, and triphenylphosphine

    International Nuclear Information System (INIS)

    The extraction behaviour of astatine was studied under defined conditions from hydrochloride acid solutions (cHCl>0.1 M or 1 and 2M). Therefore other effects like adsorption, reduction or hydrolysis can be excluded. The present work describes the extraction with tri- n- octylphosphinoxide (TOPO), tri- n-butylphosphate (TBP) and tri-phenylphosphine in chloroform. (orig.)

  4. No-carrier-added astatination of N-succinimidyl-3-(tri-n-butylstannyl) benzoate (ATE) via electrophilic destannylation

    International Nuclear Information System (INIS)

    The no-carrier-added synthesis of N-succinimidyl 3-[211At]astato-benzoate from N-succinimidyl 3-(tri-n-butylstannyl)benzoate (ATE) is described. The nature of the solvent in which the 211At was isolated from the target was an important factor influencing both the radiochemical yields and the nature of the incorporated astatine activity. (orig.)

  5. 211At-Rh(16-S4-diol) complex as a precursor for astatine radiopharmaceuticals

    International Nuclear Information System (INIS)

    211At is one of the most promising radionuclides in α-radioimmunotherapy (α-RIT). Unfortunately, biomolecules labeled by direct electrophilic astatination are unstable due to the rapid loss of 211At under both in vitro and in vivo conditions. The present paper describes the results of our studies on attaching At- to the rhodium(III) complex with thioether ligand: 1,5,9,13-etrathiacyclohexadecane-3,11-diol (16-S4-diol). Rh3+ was chosen as a moderately soft metal cation which should form very strong bonds with soft At- anions, but first of all because of the kinetic inertness of low spin rhodium(III) d6 complexes. The 16-S4-diol ligand was selected due to formation of stable complexes with Rh3+. The experiments related to optimization of the reaction conditions were performed with the 131I, basing on a chemical similarity of I- to At-. The experiments with 211At were then carried out under the conditions found optimal for I-. The preliminary results are promising, and indicate a possibility for astatination of biomolecules by using the 211At-Rh(16-S4-diol) complex

  6. Osmium-191 → iridium-191m radionuclide generator: development and clinical application. Progress report, March 1, 1981-February 28, 1982

    International Nuclear Information System (INIS)

    A prototype osmium-191 (T 1/2 = 16 days) → iridium-191m (T 1/2 = 4.9 seconds) generator designed for first pass radionuclide angiography was developed in our laboratory (Os-191 → Ir-191m). Our generator had 14 to 20% Ir-191m yield and a 1 to 3 x 10-3% Os-191 breakthrough. Iridium-191m decays with emission of a 65 and a 129 keV photon in 50% and 25% abundance respectively. This radionuclide is advantageous for angiography since it provides higher photon flux and results in much lower radiation dose to the patient than Tc-99m. One objective of this research is to improve the Os-191 → Ir-191m generator for first pass radionuclide angiography at an increase in the Ir-191m yield and a decrease in the Os-191 breakthrough. In addition, we would like to develop an Os-191 → Ir-191m generator for continuous infusion which will be used for ECG gated blood pool ventriculography, venography, and arteriography. Another approach will be to develop a carrier free Os-191 → Ir-191m generator in combination with organic or inorganic exchangers. Iridium-191m from our current generator has been employed successfully in two patient studies for the quantitation left-to-right shunting and the measurement of right and left ventricular ejection fractions. These types of studies will be expanded and further evaluated

  7. Development of the osmium-191 → iridium-191m radionuclide generator. Annual report

    International Nuclear Information System (INIS)

    The use of /sup 191m/Ir in radionuclide angiography has been the subject of increasing interest in recent years. The 191Os-/sup 191m/Ir generator that has been used for these studies suffers, however, from low /sup 191m/Ir yield (10%/ml) and higher than desirable 191Os breakthrough (5 x 10-3%). We have recently developed a /sup 191m/Ir generator that has higher yield (25 to 30%/ml) and lower breakthrough (-4%) when eluted with an eluent (0.001 M oxalic acid/0.9% saline) that does not require buffering prior to injection. Studies within the last year have shown the eluate of this generator to be non-toxic at up to 100 times the expected human dose and work is in progress to obtain approval for human use of this system. While a significant improvement over past generator designs, the yield of this generator is still modest and the evaluation of new osmium complexes for use on the generator has continued. Clinical studies involving the use of /sup 191m/Ir for first-pass angiography in adults and children have continued. A comparison of ejection fractions measured in adults with both /sup 99m/Tc and /sup 191m/Ir has confirmed the feasibilty of /sup 191m/Ir for radionuclide angiography in both the left and right ventricles of adults. Studies in collaboration with Baylor Medical College have demonstrated the efficacy of /sup 191m/Ir in combination with the multi-wire gamma camera. 31 refs., 2 figs., 10 tabs

  8. 29 CFR 19.1 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... of Labor RIGHT TO FINANCIAL PRIVACY ACT § 19.1 Definitions. For purposes of this regulation, the term... institution pertaining to a customer's relationship with the financial institution. (c) Person means an individual or a partnership of five or fewer individuals. (d) Customer means any persons or...

  9. 19 CFR 191.101 - Drawback allowance.

    Science.gov (United States)

    2010-04-01

    ... Preparations (Including Perfumery) Manufactured From Domestic Tax-Paid Alcohol § 191.101 Drawback allowance. (a... perfumery) manufactured or produced in the United States in part from the domestic tax-paid alcohol. (b... tax on flavoring extracts or medicinal or toilet preparations (including perfumery) manufactured...

  10. Development of a new osmium-191-iridium-191m radionuclide generator. Annual report

    International Nuclear Information System (INIS)

    The major limitation of the Cheng generator design is the chemical instability of the parent trans-dioxotetrachloroosmate(VI) complex. Efforts reported here were directed towards the evaluation of alternative osmium complexes for use as the parent species. Several non-chloro osmium complexes were synthesized that proved to be promising for generator applications and 191Os-/sup 191m/Ir generators were subsequently developed using these complexes as the parent species. One of these generators (''oxalate'') was found to be particularly promising and has been optimized for potential human use (IND application pending). Although the ''oxalate'' generator provides twice the /sup 191m/Ir yield and less than one-tenth the 191Os breakthrough of earlier designs, the yield of the generator remains low (30%/mL) and decreases with time to 15 to 20%/mL. 16 refs., 16 tabs

  11. Chemical and physical parameters affecting the performance of the Os-191/Ir-191m generator

    International Nuclear Information System (INIS)

    The development of an Os-191/Ir-191m generator suitable for radionuclide angiography in humans has elicited much interest. This generator employs ''(OsO2Cl4)2-'' on AG MP-1 anion exchange resin with a Dowex-2 scavenger column and is eluted with normal saline at pH 1. The parent Os species is, however, neither welldefined nor homogeneous leading to less than optimal breakthrough of Os-191 (5 x 10-3%) and modest Ir-191m yield (10-15%). The effect of a range of parameters on generator performance has been evaluated as has been the way in which the assembly and loading process affects generator performance. In addition, a number of potential alternative generator systems have been evaluated

  12. Proposal for the production of carrier-free osmium-191

    International Nuclear Information System (INIS)

    The 191Os→/sup 191m/Ir generator currently uses neutron-irradiated osmium as the source of the parent nuclide, which results in low specific activity of 191Os. Proton-induced spallation of lead targets might be a source of higher specific activity 191Os for use in a carrier-free generator system. The availability of 185Os, another product of the spallation reaction, will allow breakthrough studies to assess the feasibility of such a generator

  13. 19 CFR 191.8 - Specific manufacturing drawback ruling.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Specific manufacturing drawback ruling. 191.8...; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK General Provisions § 191.8 Specific manufacturing drawback ruling. (a) Applicant. Unless operating under a general manufacturing drawback ruling (see § 191.7),...

  14. 10 CFR 431.191 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Purpose and scope. 431.191 Section 431.191 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Distribution Transformers § 431.191 Purpose and scope. This subpart contains energy conservation requirements for distribution...

  15. 27 CFR 24.191 - Segregation of operations.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Segregation of operations. 24.191 Section 24.191 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS WINE Production of Effervescent Wine § 24.191 Segregation of...

  16. 19 CFR 191.53 - Restructuring of claims.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Restructuring of claims. 191.53 Section 191.53... TREASURY (CONTINUED) DRAWBACK Completion of Drawback Claims § 191.53 Restructuring of claims. (a) General... manufacturing drawback ruling. (b) Exemption from restructuring; criteria. In order to be exempt from...

  17. 19 CFR 19.1 - Classes of customs warehouses.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Classes of customs warehouses. 19.1 Section 19.1 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS WAREHOUSES, CONTAINER STATIONS AND CONTROL OF MERCHANDISE THEREIN § 19.1 Classes...

  18. 19 CFR 191.44 - Destruction under Customs supervision.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Destruction under Customs supervision. 191.44 Section 191.44 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Rejected Merchandise § 191.44 Destruction under...

  19. 19 CFR 191.164 - Return to Customs custody.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Return to Customs custody. 191.164 Section 191.164 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... to Sample or Specifications § 191.164 Return to Customs custody. There is no time limit for...

  20. 19 CFR 191.25 - Destruction under Customs supervision.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Destruction under Customs supervision. 191.25 Section 191.25 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Manufacturing Drawback § 191.25 Destruction under...

  1. Dicty_cDB: SLC191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ycdb.biol.tsukuba.ac.jp/CSM/SL/SLC1-D/SLC191Q.Seq.d/ Representative seq. ID SLC19...1Z (Link to Original site) Representative DNA sequence >SLC191 (SLC191Q) /CSM/SL/SLC1-D/SLC191Q.Seq.d/ XXXXX...ETTYNSIMKCDVDIRKDLYGN VVLSGGTTMFPGIADRMNKELTALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMW ISKEEYDESGPSIVHRKCF*tiktsdesas...IHETTYNSIMKCDVDIRKDLYGN VVLSGGTTMFPGIADRMNKELTALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMW ISKEEYDESGPSIVHRKCF*tiktsdesas...mic 36.0 %: nuclear 12.0 %: mitochondrial 8.0 %: vacuolar 4.0 %: peroxisomal 4.0 %: endoplasmic reticulum >> pre

  2. Development of the osmium-191/iridium-191m radionuclide generator. Progress report

    International Nuclear Information System (INIS)

    The use of the ultrashort-lived radionuclide Ir-191m (T/sub 1/2/=5s) for first-pass radionuclide angiography produces lower patient radiation dose, higher photon flux, and allows repeated studies that are not possible with the radionuclide currently employed for these studies (Tc-99m; T/sub 1/2/=6h). An Os-191->Ir-191m radionuclide generator suitable for human use was developed in our laboratory and has been used in a number of clinical studies. This generator design suffers, however, from high breakthrough (5 x 10-3%), low yield (10-15%), and an eluent (pH 1 saline) that must be buffered prior to injection. In an effort to increase Ir-191m yield and decrease Os-191 breakthrough, the generator assembly process has been examined carefully and a detailed, reproducible assembly process developed. A variety of approaches have been used in an attempt to improve the performance of the current generator design but, as yet, only modest improvements have been realized. The investigation of new generator designs has, however, produced a new generator with substantially higher yield (30-35%), lower breakthrough (2-3 x 10-3%), and an eluent that does not require buffering prior to injection. Efforts are currently underway to improve the stability and evaluate the toxicity of this system

  3. The development of an 191Os → sup(191m)Ir generator using an osmium chelate parent complex

    International Nuclear Information System (INIS)

    A 191Os→sup(191m)Ir generator has been developed that has higher sup(191m)Ir yield and lower 191Os breakthrough than previous designs. These improvements have been realized through the use of the osmium chelate complex trans-dioxobismalonatoosmate(VI) as the parent species on the generator. The new generator provides an intitial sup(191m)Ir yield of 40%/mL and 191Os breakthrough of 2-3 x 10-3% when eluted with a solution of 0.05 M malonic acid/0.10 M sodium chloride at pH 4. Other advantages of the new design include faster clearance of the 191Os breakthrough products and simpler assembly. (author)

  4. 191mIr: Distribution and retention in animal experiments

    International Nuclear Information System (INIS)

    Ultrashort-lived tracer 191mIr (T1/2=4.96 s) can be obtained with a high yield from an 191Os/191mIr generator with a low 191Os breakthrough. It was eluated directly into the tail veins of Wistar rats. These animals were imaged dynamically (five frames/s) up to 40 s. The measurement was repeated five times on each animal. The whole-body retention and biodistribution of 191Os was studied by sacrificing the rats at one and four days, respectively, after injection. The activity retained was highest in the kidneys and the spleen, followed by the muscles and the liver. These values indicate that the breakthrough is by no means dangerous and that investigations can be repeated immediately with a radiation exposure of no significance. Furthermore, all investigations in the same animal were reproducible, suggesting that 191mIr might be a good tracer for nuclear angiograms. (orig.)

  5. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.

    Science.gov (United States)

    Guérard, François; Lee, Yong-Sok; Baidoo, Kwamena; Gestin, Jean-François; Brechbiel, Martin W

    2016-08-22

    Aryliodonium salts have become precursors of choice for the synthesis of (18) F-labeled tracers for nuclear imaging. However, little is known on the reactivity of these compounds with heavy halides, that is, radioiodide and astatide, at the radiotracer scale. In the first comparative study of radiohalogenation of aryliodonium salts with (125) I(-) and (211) At(-) , initial experiments on a model compound highlight the higher reactivity of astatide compared to iodide, which could not be anticipated from the trends previously observed within the halogen series. Kinetic studies indicate a significant difference in activation energy (Ea =23.5 and 17.1 kcal mol(-1) with (125) I(-) and (211) At(-) , respectively). Quantum chemical calculations suggest that astatination occurs via the monomeric form of an iodonium complex whereas iodination occurs via a heterodimeric iodonium intermediate. The good to excellent regioselectivity of halogenation and high yields achieved with diversely substituted aryliodonium salts indicate that this class of compounds is a promising alternative to the stannane chemistry currently used for heavy radiohalogen labeling of tracers in nuclear medicine. PMID:27305065

  6. Superdeformation studies in {sup 191}Hg

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, M.P.; Janssens, R.V.F.; Crowell, B. [and others

    1995-08-01

    Superdeformation in the A {approximately} 190 region was first observed in {sup 191}Hg from an experiment performed at ATLAS using the Argonne Notre Dame {gamma}-ray facility. We recently revisited the study of superdeformation in this nucleus using Gammasphere and the {sup 160}Gd({sup 36}S,5n) and {sup 174}Yb({sup 22}Ne,5n) reactions at 172 and 120 MeV in order to populate and measure states in the second well. The goal of the experiment was to identify new bands in the data, and thus allow us to gain understanding on the relative placement of single particle orbitals near the N = 112 SD shell gap. From an analysis of the data, the three previously identified SD bands were extended, and their feeding into the yrast states delineated. Two new SD bands were observed and preliminary evidence for a third new band was obtained as well.

  7. High spin levels in {sup 191}Pb; Niveaux de grand moment angulaire dans {sup 191}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Lagrange, J.M.; Pautrat, M. [Inst. de Physique Nucleaire, Paris-11 Univ., 91 - Orsay (France); Dionisio, J.S.; Vieu, Ch. [Centre de Spectrometrie Nucleaire et de Spectrometrie de Masse, Centre National de la Recherche Scientifique, 91 - Orsay (France); Vanhorenbeeck, J. [I.A.A. Universite Libre de Bruxelles, C.P. 226, Boulevard du Triomphe 1050, Bruxelles (Belgium)

    1998-12-31

    The {sup 191}Pb isotope, produced through different A(b,xn){sup 191}Pb reactions, where b stands for nuclei as {sup 16}O, {sup 20}Ne and {sup 31}P, is studied. The half-lives of some excited levels being greater that 10 ns, the recoil catcher method is suitable. The study of the de-excitation {gamma} ray and conversion electron spectra, together with {gamma} - {gamma} and {gamma} - e{sup -} coincidence measurements leads to a level scheme. The characteristics are similar to those observed in {sup 193}Pb. This experimental level scheme is compared to the theoretical one obtained through a microscopic calculation in a three quasi-particle approximation, using a surface delta interaction with a reduce pairing component. The conclusions reached are very close to those for the {sup 193}Pb study. (authors) 7 refs., 6 figs., 2 tabs.

  8. 49 CFR 192.191 - Design pressure of plastic fittings.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Design pressure of plastic fittings. 192.191... Components § 192.191 Design pressure of plastic fittings. (a) Thermosetting fittings for plastic pipe must conform to ASTM D 2517, (incorporated by reference, see § 192.7). (b) Thermoplastic fittings for...

  9. 19 CFR 191.7 - General manufacturing drawback ruling.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false General manufacturing drawback ruling. 191.7...; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK General Provisions § 191.7 General manufacturing drawback ruling. (a) Purpose; eligibility. General manufacturing drawback rulings are designed to...

  10. 19 CFR 191.26 - Recordkeeping for manufacturing drawback.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Recordkeeping for manufacturing drawback. 191.26...; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Manufacturing Drawback § 191.26 Recordkeeping for manufacturing drawback. (a) Direct identification manufacturing—(1) Records required. Each manufacturer...

  11. 19 CFR 191.37 - Destruction under Customs supervision.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Destruction under Customs supervision. 191.37 Section 191.37 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Customs supervision. A claimant may destroy merchandise and obtain unused merchandise drawback...

  12. 19 CFR 191.153 - Continuous Customs custody.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Continuous Customs custody. 191.153 Section 191.153 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Merchandise Exported From Continuous Customs Custody §...

  13. 19 CFR 191.152 - Merchandise released from Customs custody.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Merchandise released from Customs custody. 191.152 Section 191.152 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) DRAWBACK Merchandise Exported From Continuous Customs Custody §...

  14. Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

    CERN Document Server

    Andreyev, Andrei

    2013-01-01

    Part I: $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with astatine beams; Part II: Delineating the island of deformation in the light gold isotopes by means of laser spectroscopy

  15. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  16. The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation

    International Nuclear Information System (INIS)

    Human zinc finger protein 191 (ZNF191/ZNF24) was cloned and characterized as a SCAN family member, which shows 94% identity to its mouse homologue zinc finger protein 191 (Zfp191). ZNF191 can specifically interact with an intronic polymorphic TCAT repeat (HUMTH01) in the tyrosine hydroxylase (TH) gene. Allelic variations of HUMTH01 have been stated to have a quantitative silencing effect on TH gene expression and to correlate with quantitative and qualitative changes in the binding by ZNF191. Zfp191 is widely expressed during embryonic development and in multiple tissues and organs in adult. To investigate the functions of Zfp191 in vivo, we have used homologous recombination to generate mice that are deficient in Zfp191. Heterozygous Zfp191 +/- mice are normal and fertile. Homozygous Zfp191 -/- embryos are severely retarded in development and die at approximately 7.5 days post-fertilization. Unexpectedly, in Zfp191 -/- and Zfp191 +/- embryos, TH gene expression is not affected. Blastocyst outgrowth experiments and the RNA interference-mediated knockdown of ZNF191 in cultured cells revealed an essential role for Zfp191 in cell proliferation. In further agreement with this function, no viable Zfp191 -/- cell lines were obtained by derivation of embryonic stem (ES) cells from blastocysts of Zfp191 +/- intercrosses or by forced homogenotization of heterozygous ES cells at high concentrations of G418. These data show that Zfp191 is indispensable for early embryonic development and cell proliferation

  17. Expression and purification of a novel ZNF191 zinc finger protein——ZNF191 protein and its truncated zinc finger region ZNF191 (243—368)

    Institute of Scientific and Technical Information of China (English)

    刘玉奇; 余龙; 余文浩; 施少林; 孙炳耘; 吴国俊; 黄仲贤

    1999-01-01

    ZNF191 is a new zine finger gene whieh has a 1107 bp open reading frame (ORF) and eneodes a 368 amino avid protein including a putative DNA-binding domain of four Cys2 His2 zine finger motifs at its C-terminal region. The ZNF191 cDNA is loeated in the chromosome 18q12.1 region where it is known that a variety of hereditary diseases are related to. Probably, this protein has potential function of stimulating the gene franscription. In order to examine the function and structure of ZNF191 protein, the ORF of ZNF191 and its zine finger region ZNF191(243--368) genes were inserted into PTSA-18 expression vector by PCR amplification, then the constructed genes were expressed in the PTSA-18/B121 (DE3) system. The two proteins were purified by DEAE-52, CM-23 and Heparin-Sepharose 4B columns. The pooled proteins showed a single band as assayed by Coomasie Brillian Blue Staining of an SDS/polyacryamide gel.

  18. Dicty_cDB: VHD191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VH (Link to library) VHD191 (Link to dictyBase) - - - Contig-U16501-1 VHD191P (Link to Original ... metagenome genomic clone 1061005863057 3', genomic survey ... sequence. 52 5e-25 6 AX489103 |AX489103.1 Sequence ... metagenome genomic clone 1061005738507 3', genomic survey ... sequence. 54 2e-21 4 AR547792 |AR547792.1 Sequence ...

  19. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  20. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  1. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    International Nuclear Information System (INIS)

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  2. Dicty_cDB: VFF191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available TAANNATCTTT Length of 3' end seq. 541 Connected seq. ID VFF191P Connected seq. >VFF191P.Seq AATTCAGCACAAACAC...AGATATTAANNAT CTTT Length of connected seq. 714 Full length Seq ID - Full length Seq. - Length of full length seq. - ... ...kleptlstlvnplikiqvl*lyqfhypplsynhhqvyxil--- ---lctlspnismvivialwvfwqqttmnstpslnsskiv...0.15 1 AE006311 |AE006311.1 Lactococcus lactis subsp. lactis IL1403 section 73 of 218 of the complete genome...ase (cystath... 234 3e-60 BC082653_1( BC082653 |pid:none) Xenopus laevis hypothetical LOC494...

  3. 47 CFR 87.191 - Foreign aircraft stations.

    Science.gov (United States)

    2010-10-01

    ... the International Civil Aviation Organization may carry and operate radio transmitters in the United... the State in which the aircraft is registered. The use of radio transmitters in the United States....191 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO...

  4. 27 CFR 1.91 - Bottled distilled spirits.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bottled distilled spirits..., NONINDUSTRIAL USE OF DISTILLED SPIRITS AND WINE, BULK SALES AND BOTTLING OF DISTILLED SPIRITS Bulk Sales and Bottling of Distilled Spirits Warehouse Receipts § 1.91 Bottled distilled spirits. The provisions of...

  5. 40 CFR 180.191 - Folpet; tolerances for residues.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Folpet; tolerances for residues. 180... PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.191 Folpet; tolerances for residues. (a) General. Tolerances are established for the fungicide folpet...

  6. Ferimentos cervicais: análise retrospectiva de 191 casos Neck injuries: retrospective analysis of 191

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Von Bahten

    2003-10-01

    Full Text Available OBJETIVOS: Analisar a epidemiologia e a conduta nos ferimentos cervicais. MÉTODO: Foram analisados 487.128 prontuários de pacientes que ingressaram no Serviço de Emergência do Hospital Universitário Cajuru no período de 01/1996 a 06/2001. Destes, selecionaram-se 378 pacientes com ferimentos cervicais. Foram excluídos 153 que apresentavam lesões associadas e 14 por óbito no atendimento inicial. O estudo foi feito , assim, em 191 pacientes com les��es cervicais exclusivas. Avaliou-se a localização da ferida, o mecanismo de trauma, o comprometimento do platisma, sinais e sintomas, a hora de admissão e a conduta empregada. RESULTADOS: Cento e sessenta e quatro (86% pacientes eram masculinos. A média de idade foi de 28 anos (10-72. Noventa (47% ferimentos foram por arma de fogo (FAF e 88 (46% por arma branca (FAB. O principal horário de admissão foi entre 20 e 04 horas. Quanto à localização, 53% das lesões foram à esquerda, 45% à direita e 2% medianos; 36% em zona I, 55% em zona II e 9% em zona III. Em 101 o ferimento penetrou o platisma: cinqüenta e um (50% apresentaram sinais e sintomas clínicos e receberam conduta operatória. As lesões vasculares foram as mais encontradas (20. Houve 24 (47% cervicotomias não-terapêuticas. O tratamento conservador foi empregado em 41 (45% casos de acordo com os exames físico e complementares. CONCLUSÕES: Homens jovens são mais acometidos quanto aos ferimentos cervicais. Estes ocorrem mais freqüentemente na zona II, e a incidência dos FAF e FAB foi equivalente. É adequado um manejo mais seletivo em relação aos ferimentos cervicais, devendo o manejo da zona II adequar-se à disposição de recursos dos serviços de trauma.BACKGROUND: The study proposes to assess the demographics and management of neck injuries. METHODS: A retrospective review of 487.128 emergency department medical records from 01/1996 to 06/2001 was conducted. Out of the 378 patients selected for the analysis

  7. Stability and in vivo behavior of Rh[16aneS4-diol]211At complex: A potential precursor for astatine radiopharmaceuticals

    International Nuclear Information System (INIS)

    Introduction: The heavy halogen 211At is of great interest for targeted radiotherapy because it decays by the emission of short-range, high-energy α-particles. However, many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking other 211At labeling strategies. One relatively unexplored approach is to utilize prosthetic groups based on astatinated rhodium (III) complex stabilized with a tetrathioether macrocyclic ligand – Rh[16aneS4-diol]211At. The purpose of the current study was to evaluate the in vitro and in vivo stability of this complex in comparison to its iodine analog – Rh[16aneS4-diol]131I. Methods: Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I complexes were synthesized and purified by HPLC. The stability of both complexes was evaluated in vitro by incubation in phosphate-buffered saline (PBS) and human serum at different temperatures. The in vivo behavior of the two radiohalogenated complexes was assessed by a paired-label biodistribution study in normal Balb/c mice. Results: Both complexes were synthesized in high yield and purity. Almost no degradation was observed for Rh[16aneS4-diol]131I in PBS over a 72 h incubation. The astatinated analog exhibited good stability in PBS over 14 h. A slow decline in the percentage of intact complex was observed for both tracers in human serum. In the biodistribution study, retention of 211At in most tissues was higher than that of 131I at all time points, especially in spleen and lungs. Renal clearance of Rh[16aneS4-diol]211At and Rh[16aneS4-diol]131I predominated, with 84.1 ± 2.3% and 94.6 ± 0.9% of injected dose excreted via the urine at 4 h. Conclusions: The Rh[16aneS4-diol]211At complex might be useful for constructing prosthetic groups for the astatination of biomolecules and further studies are planned to evaluate this possibility

  8. 19 CFR Appendix A to Part 191 - General Manufacturing Drawback Rulings

    Science.gov (United States)

    2010-04-01

    ... regulations and rulings (see 19 CFR 191.11). H. Stock In Process Stock in process does not result; or if it... applicable, as well as 19 CFR part 191 (see particularly, § 191.9). A. Name and Address of Principal B... provision of 19 U.S.C. 1313(a) upon the exportation of linseed oil, linseed oil cake, and linseed oil...

  9. 28 CFR 0.191 - Changes which affect the overall structure of the Department.

    Science.gov (United States)

    2010-07-01

    ... structure of the Department. 0.191 Section 0.191 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Sections and Subunits § 0.191 Changes which affect the overall structure of the Department. Changes to the overall structure of the Department include: The...

  10. 19 CFR 191.184 - Merchandise transferred from continuous Customs custody.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Merchandise transferred from continuous Customs custody. 191.184 Section 191.184 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... From Customs Territory § 191.184 Merchandise transferred from continuous Customs custody. (a)...

  11. Evaluation of osmium(II)-nitrosyl complexes as a method to increase the yield of the 191Os-191mIr generator

    International Nuclear Information System (INIS)

    The nitrosyl complexes pentachloronitrosylosmate (II), [OsCl5(NO)]2-, and hydroxytetranitronitrosylosmate (II), [Os(OH)(NO2)4(NO)]2-, were evaluated as parent species for use on the 191Os-191mIr generator in an attempt to increase the 191mIr yield of the generator by providing a direct route to a chemically stable 191mIr daughter.The uptake of the 191Os-labeled complexes by the inorganic ion-exchangers ZrO2, SnO2, PbS, MnO2 and Al2O3 and the organic resin AG MP-1 was measured and prototype generators were prepared using those exchangers that demonstrated greater than 90% uptake the 191Os-labeled complexes. The 191mIr(III)-nitrosyl complexes produced subsequent to β- decay of the 191Os-nitrosyl parent complexes were found to undergo secondary chemical reactions to form nitro (NO2-) complexes that were tightly retained on the ion exchanger limiting 191mIr yield to less than 5%. (author)

  12. Cascade γ-decay of the 191Os compound nucleus

    International Nuclear Information System (INIS)

    Two-step cascades from the (nth, γ) reaction were studied in γ - γ coincidence measurements. The decay scheme of 191Os was established up to the excitation energy ∼ 3 MeV. The excitation spectrum of intermediate levels of most intense cascades was found to be harmonic. The sum radiative strength functions for E1 and M1 transitions were estimated over the energy interval from 520 keV to Bn - 520 keV. A comparison of the obtained data with the model calculations provided deeper insight into the parameters of γ-decay of a number of nuclei from the mass region 114 ≤ A ≤ 200

  13. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  14. Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter

    International Nuclear Information System (INIS)

    The sodium/iodide symporter (NIS) has been recognized as an attractive target for radioiodine-mediated cancer gene therapy. In this study we investigated the role of human NIS for cellular uptake of the high LET α-emitter astatine-211 (211At) in comparison with radioiodine as a potential radionuclide for future applications. A mammalian NIS expression vector was constructed and used to generate six stable NIS-expressing cancer cell lines (three derived from thyroid carcinoma, two from colon carcinoma, one from glioblastoma). Compared with the respective control cell lines, steady state radionuclide uptake of NIS-expressing cell lines increased up to 350-fold for iodine-123 (123I), 340-fold for technetium-99m pertechnetate (99mTcO4-) and 60-fold for 211At. Cellular 211At accumulation was found to be dependent on extracellular Na+ ions and displayed a similar sensitivity towards sodium perchlorate inhibition as radioiodide and 99mTcO4- uptake. Heterologous competition with unlabelled NaI decreased NIS-mediated 211At uptake to levels of NIS-negative control cells. Following uptake both radioiodide and 211At were rapidly (apparent t1/2 3-15 min) released by the cells as determined by wash-out experiments. Data of scintigraphic tumour imaging in a xenograft nude mice model of transplanted NIS-modified thyroid cells indicated that radionuclide uptake in NIS-expressing tumours was up to 70 times (123I), 25 times (99mTcO4-) and 10 times (211At) higher than in control tumours or normal tissues except stomach (3-5 times) and thyroid gland (5-10 times). Thirty-four percent and 14% of the administered activity of 123I and 211At, respectively, was found in NIS tumours by region of interest analysis (n=2). Compared with cell culture experiments, the effective half-life in vivo was greatly prolonged (6.5 h for 123I, 5.2 h for 211At) and preliminary dosimetric calculations indicate high tumour absorbed doses (3.5 Gy/MBqtumour for 131I and 50.3 Gy/MBqtumour for 211At). In

  15. The effect of decomposition of trans-dioxobisoxalatoosmate(II) on the performance of the 191Os-191mIr (oxalate) generator

    International Nuclear Information System (INIS)

    Iridium-191m (t1/2 = 5 s) offers a number of clinical advantages over 99mTc for first-pass radionuclide angiography. The yield of the 191Os-191mIr generators that have been developed to date is, however, less than optimal (∼20%). The open-quotes oxalateclose quotes generator, developed in the authors' laboratory, which uses trans-dioxobisoxalatoosmate(II) (1) as the parent species, initially provides a higher yield of 191mIr, but the yield of this generator decreases with time, presumably because of decomposition of the parent complex. In an effort to understand the reasons for this phenomenon and possibly circumvent the problem of decreasing yield, studies of the stability of 1 were undertaken. These studies revealed that 1 decomposes when dissolved in the generator eluent at concentrations similar to those present on the generator, but is stable when the concentration of oxalic acid is greater than the concentration of 1. Similarly, irradiation of solutions of 1 in excess oxalic acid reveal no decomposition of the complex at a dose of 1 krad. These observations are now being applied to the development of an improved 191Os-191mIr generator

  16. 19 CFR Appendix B to Part 191 - Sample Formats for Applications for Specific Manufacturing Drawback Rulings

    Science.gov (United States)

    2010-04-01

    ... Manufacturing Drawback Rulings B Appendix B to Part 191 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION... to Part 191—Sample Formats for Applications for Specific Manufacturing Drawback Rulings Table of Contents I. General. II. Format for Application for Specific Manufacturing Drawback Ruling Under 19...

  17. 50 CFR 216.191 - Designation of Offshore Biologically Important Marine Mammal Areas.

    Science.gov (United States)

    2010-10-01

    ...) Detailed information on the biology of marine mammals within the area, including estimated population size... Important Marine Mammal Areas. 216.191 Section 216.191 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE...

  18. 27 CFR 479.191 - Applicability of other provisions of internal revenue laws.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Applicability of other provisions of internal revenue laws. 479.191 Section 479.191 Alcohol, Tobacco Products, and Firearms BUREAU... other provisions of internal revenue laws. All of the provisions of the internal revenue laws...

  19. 19 CFR 191.14 - Identification of merchandise or articles by accounting method.

    Science.gov (United States)

    2010-04-01

    ... accounting method. 191.14 Section 191.14 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF... Identification of merchandise or articles by accounting method. (a) General. This section provides for the identification of merchandise or articles for drawback purposes by the use of accounting methods. This...

  20. 19 CFR 191.71 - Drawback on articles destroyed under Customs supervision.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Drawback on articles destroyed under Customs supervision. 191.71 Section 191.71 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... articles destroyed under Customs supervision. (a) Procedure. At least 7 working days before the...

  1. 19 CFR 191.1 - Authority of the Commissioner of Customs.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Authority of the Commissioner of Customs. 191.1 Section 191.1 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Customs. Pursuant to Treasury Department Order No. 165, Revised (T.D. 53654, 19 FR 7241), as amended,...

  2. Detection and quantitation of left-to-right shunting by iridium-191m angiography

    International Nuclear Information System (INIS)

    An osmium-191→iridium-191m radionuclide generator suitable for first-pass angiography has been developed. Osmium-191 with a physical half-life of 15.4 days is produced in the reactor by the 190Os(eta,γ) 191Os reaction and decays by internal conversion to 191Irsup(m). Iridium-191m has a physical half-life of 4.96s and decays by isometric transition to stable 191Ir. It emits a gamma ray at 129keV with 30% abundance. In addition, X-rays at about 65keV in 58% abundance are emitted as a result of internal conversion from the 129keV excited state. Osmium-191 metal is converted into potassium osmate, which is loaded into a column of 0.9ml of AGMP-1 anion exchange resin. This column is connected in series to another column also of 0.9ml of Dowex-2 and pyrocatechol. The generator is eluted with 0.6 to 1ml of 0.9%NaCl, pH 1. One ml of eluant yields 7 to 10% of the 191Irsup(m) in the column and there is a 3 to 5%x10-3% of 191Os breakthrough. The eluant is rapidly diluted and flushed with a buffer solution (25% 0.05MNa2HPO4, 75% 0.9%NaCl) before injection. The lowest pH delivered is 3.5. First-pass radionuclide angiography has been carried out in 59 patients ranging from four days to 67 years of age (mean=14 years) for detection and quantitation of left-to-right shunting. Twelve patients underwent cardiac catheterizations with simultaneous 191Irsup(m) angiography. They had pulmonary-to-systemic ratios (Qp:Qs) ranging from 1.04 to 3.00. There was good agreement between these two techniques (r=0.90). In addition to the quantitation of Qp:Qs, it appears that 191Irsup(m) is useful in the evaluation of cardiac function. The relatively long half-life of 191Os will permit transport of the generator to centres far from the production facility. The major advantages of 191Irsup(m) are: (1) low radiation dose to patients; (2) high photon flux; and (3) the possibility of obtaining repeated studies within a short time. (author)

  3. Establishment of radioactive astatine and iodine uptake in cancer cell lines expressing the human sodium/iodide symporter

    Energy Technology Data Exchange (ETDEWEB)

    Petrich, T.; Helmeke, H.-J.; Meyer, G.J.; Knapp, W.H.; Poetter, E. [Department of Nuclear Medicine, Medizinische Hochschule Hannover (Germany)

    2002-07-01

    The sodium/iodide symporter (NIS) has been recognized as an attractive target for radioiodine-mediated cancer gene therapy. In this study we investigated the role of human NIS for cellular uptake of the high LET {alpha}-emitter astatine-211 ({sup 211}At) in comparison with radioiodine as a potential radionuclide for future applications. A mammalian NIS expression vector was constructed and used to generate six stable NIS-expressing cancer cell lines (three derived from thyroid carcinoma, two from colon carcinoma, one from glioblastoma). Compared with the respective control cell lines, steady state radionuclide uptake of NIS-expressing cell lines increased up to 350-fold for iodine-123 ({sup 123}I), 340-fold for technetium-99m pertechnetate ({sup 99m}TcO{sub 4}{sup -}) and 60-fold for {sup 211}At. Cellular {sup 211}At accumulation was found to be dependent on extracellular Na{sup +} ions and displayed a similar sensitivity towards sodium perchlorate inhibition as radioiodide and {sup 99m}TcO{sub 4}{sup -} uptake. Heterologous competition with unlabelled NaI decreased NIS-mediated {sup 211}At uptake to levels of NIS-negative control cells. Following uptake both radioiodide and {sup 211}At were rapidly (apparent t{sub 1/2} 3-15 min) released by the cells as determined by wash-out experiments. Data of scintigraphic tumour imaging in a xenograft nude mice model of transplanted NIS-modified thyroid cells indicated that radionuclide uptake in NIS-expressing tumours was up to 70 times ({sup 123}I), 25 times ({sup 99m}TcO{sub 4}{sup -}) and 10 times ({sup 211}At) higher than in control tumours or normal tissues except stomach (3-5 times) and thyroid gland (5-10 times). Thirty-four percent and 14% of the administered activity of {sup 123}I and {sup 211}At, respectively, was found in NIS tumours by region of interest analysis (n=2). Compared with cell culture experiments, the effective half-life in vivo was greatly prolonged (6.5 h for {sup 123}I, 5.2 h for {sup 211}At) and

  4. Rapid renal single-photon emission tomography by continuous infusion of iridium-191m

    International Nuclear Information System (INIS)

    Continuous infusion of iridium-191m (t1/2 = 5 s), produced with an 191Os/191mIr generator, was used to obtain rapid high-resolution single-photon emission tomography (SPET) of renal blood flow in the rabbit. SPET scans of the abdomen were obtained with a triple-detector SPET system (MS3, Siemens Gammasonics). The generator was eluted at a flow rate of 3 ml/min, which delivered a steady-state dose of 170 MBq (4.5 mCi) of 191mIr. The total 191Os breakthrough was 850 kBq (23 μCi). A 5-min SPET acquisition recorded a total of 2.8 million counts, resulting in images of high technical quality. Volume-rendered images clearly showed the abdominal aorta, splenic artery, spleen, renal arteries, kidneys and splanchnic vasculature. Tomographic slices through the kidneys revealed tracer primarily within the renal cortices without visualization of the collecting system. The estimated effective dose equivalent for a 5 min infusion of 191mIr at a steady-state dose of 170 MBq is 0.74 mSv compared with 2.7 mSv from a 170 MBq dose of 99mTc-DMSA. This study demonstrates the feasibility of high-resolution SPET of regional renal perfusion in the rabbit by continuous intravenous infusion of 191mIr. The renal distribution of continuously infused 191mIr is largely within the cortices, with minimal or no detectable activity in the region of the renal pelvicalyceal system. Using this technique, cortical renal SPET can be completed much more rapidly (191mIr that occur in animal models of altered renal perfusion. (orig.)

  5. 26 CFR 1.501(c)(19)-1 - War veterans organizations.

    Science.gov (United States)

    2010-04-01

    ...) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Exempt Organizations § 1.501(c)(19)-1 War veterans... dependents, and the widows and orphans of deceased veterans, (3) To provide entertainment, care,...

  6. SUBIECTUL INFRACŢIUNILOR PREVĂZUTE LA ART.191 CP RM

    Directory of Open Access Journals (Sweden)

    Irina SELEVESTRU

    2015-11-01

    Full Text Available În cadrul acestui studiu se face analiza caracteristicilor subiectului infracţiunilor prevăzute la art.191 CP RM. Se constată că este justificată stabilirea limitei minime de vârstă a răspunderii penale de 16 ani pentru subiectul acestor infracţiuni. În continuare, sunt identificate cele şase condiţii pe care trebuie să le îndeplinească administratorul ca subiect al infracţiunilor specificate la art.191 CP RM. Se demonstrează că guvernatorul BNM nu poate avea calitatea de subiect al infracţiunii prevăzute la alin.(21 art.191 CP RM. În schimb, acesta poate avea calitatea de subiect al infracţiunilor specificate la alin.(1, (2, (3-(5 art.191 CP RM. Se argumentează că, în sensul alin.(21 art.191 CP RM, administrator al băncii este persoana fizică care nu neapărat administrează o bancă ca pe o persoană juridică. Important este altceva: administratorul băncii trebuie să fie învestit prin lege sau statut să-şi asume obligaţii, de sine stătător sau împreună cu alte persoane, în numele şi în contul băncii. În lipsa acestei condiţii, nu putem vorbi despre administrator al băncii în sensul alin.(21 art.191 CP RM.THE SUBJECT OF THE OFFENCES REFFERED TO AT ART.191 PC RM SUMMARYIn this study are analyzed the characteristics of the subject of the offences set forth in art.191 PC RM. Concerning this matter is stated that it is perfectly justified to establish the minimum age of 16 years for the penal liability of the subject to these offences. There have been also identified the six conditions that must be met by the manager in order to be considered the subject of the offences specified at art.191 PC RM. It is demonstrated that the Governor of NBM cannot comprise the quality of subject of the offence as provided by par.(21 art.191 PC RM. Instead, he may attract the quality of subject of the offences referred to at par.(1, (2, (3-(5 art.191 PC RM. It is argued that, under par.(21 art.191 PC RM, the manager of

  7. Production of 191Pt radiotracer with high specific activity for the development of preconcentration procedures

    Science.gov (United States)

    Parent, M.; Strijckmans, K.; Cornelis, R.; Dewaele, J.; Dams, R.

    1994-04-01

    A radiotracer of Pt with suitable nuclear characteristics and high specific activity (i.e. activity to mass ratio) is a powerful tool when developing preconcentration methods for the determination of base-line levels of Pt in e.g. environmental and biological samples. Two methods were developed for the production of 191Pt with high specific activity and radionuclidic purity: (1) via the 190Pt(n, γ) 191Pt reaction by neutron irradiation of enriched Pt in a nuclear reactor at high neutron fluence rate and (2) via the 191Ir(p, n) 191Pt reaction by proton irradiation of natural Ir with a cyclotron, at an experimentally optimized proton energy. For the latter method it was necessary to separate Pt from the Ir matrix. For that reason either liquid-liquid extraction with dithizone or adsorption chromatography were used. The yields, the specific activities and the radionuclidic purities were experimentally determined as a function of the proton energy and compared to the former method. The half-life of 191Pt was accurately determined to be 2.802 ± 0.025 d.

  8. Search for entrance-channel dependence in the population of superdeformed bands in {sup 191}Hg

    Energy Technology Data Exchange (ETDEWEB)

    Soramel, F.; Khoo, T.L.; Janssens, R.V.F. [and others

    1995-08-01

    The population intensity of some SD bands in the mass 150 region were observed to depend on the mass symmetry of the entrance channel in the fusion reaction. The authors raised the possibility that the population of SD bands had a memory of the entrance channel. To check this interesting possibility, we made measurements of the population intensities of superdeformed (SD) bands in the {sup 160}Gd({sup 36}S,5n){sup 191}Hg and {sup 130}Te({sup 64}Ni,3n){sup 191}Hg reactions. To ensure that any observed effect was not due to a simple angular momentum difference in the entrance channels, we also measured the average entry points and spin distributions of normal and SD states in {sup 191}Hg in the two reactions. The entry points and spin distributions for {sup 191}Hg are the same and, indeed, so are the SD intensities in the two reactions. Hence, no entrance-channel effect is observed in the population of the SD band in {sup 191}Hg, in contrast with data for SD bands in the mass 150 regions. We suggest that the effect observed previously in the mass 150 region is due to an angular momentum effect. A letter reporting our results was submitted for publication.

  9. Studies of radioactive cisplatin ({sup 191}Pt) for tumour imaging and therapy

    Energy Technology Data Exchange (ETDEWEB)

    Areberg, J

    2000-01-01

    A radioactive variant of the cytostatic agent cis-dichlorodiammineplatinum(II), cisplatin, was synthesised from {sup 191}PtCl{sub 4}. The {sup 191}Pt-cisplatin was found to be a sterile product of high radionuclide, radiochemical and chemical purity. The pharmacokinetics of platinum in tumour tissue and organs at risk of fourteen patients undergoing treatment with cisplatin were studied by exchanging a small fraction of the prescribed amount of cisplatin with {sup 191}Pt-cisplatin. The uptake and retention of platinum were investigated by gamma camera measurements up to ten days after infusion of {sup 191}Pt-cisplatin. Highest concentration of platinum was found in the liver, on average 5.7 {+-} 0.5 {mu}g/g normalised to a given amount of 180 mg cisplatin. Corresponding value for the kidneys was 1.9 {+-} 0.3 {mu}g/g. Uptake of platinum in tumours was visualised in five patients with an average maximum concentration of 4.9 {+-} 1.0 {mu}g/g normalised to a given amount of 180 mg cisplatin. The data from the pharmacokinetic study was used together with data from the literature to estimate the absorbed dose and effective dose to patients receiving radioactive cisplatin. The effective doses were calculated to be 0.10 {+-} 0.02 mSv/MBq, 0.17 {+-} 0.04 mSv/MBq and 0.23 {+-} 0.05 mSv/MBq for {sup 191}Pt-, {sup 193m}Pt-, and {sup 195m}Pt-cisplatin respectively. The combined effect of the radio- and chemotoxicity from {sup 191}Pt-cisplatin was investigated both in vitro and in vivo. A cervical cancer cell line was incubated with cisplatin or {sup 191}Pt-cisplatin with various concentrations and specific activities. It was shown that the surviving fraction was smaller for cells treated with {sup 191}Pt-cisplatin than for cells treated with the same concentration of non-radioactive cisplatin. The surviving fraction decreased with increasing specific activity. Isobologram technique showed that the radio- and chemotoxicity interacted in a supra-additive (synergistic) manner. In

  10. Studies of radioactive cisplatin (191Pt) for tumour imaging and therapy

    International Nuclear Information System (INIS)

    A radioactive variant of the cytostatic agent cis-dichlorodiammineplatinum(II), cisplatin, was synthesised from 191PtCl4. The 191Pt-cisplatin was found to be a sterile product of high radionuclide, radiochemical and chemical purity. The pharmacokinetics of platinum in tumour tissue and organs at risk of fourteen patients undergoing treatment with cisplatin were studied by exchanging a small fraction of the prescribed amount of cisplatin with 191Pt-cisplatin. The uptake and retention of platinum were investigated by gamma camera measurements up to ten days after infusion of 191Pt-cisplatin. Highest concentration of platinum was found in the liver, on average 5.7 ± 0.5 μg/g normalised to a given amount of 180 mg cisplatin. Corresponding value for the kidneys was 1.9 ± 0.3 μg/g. Uptake of platinum in tumours was visualised in five patients with an average maximum concentration of 4.9 ± 1.0 μg/g normalised to a given amount of 180 mg cisplatin. The data from the pharmacokinetic study was used together with data from the literature to estimate the absorbed dose and effective dose to patients receiving radioactive cisplatin. The effective doses were calculated to be 0.10 ± 0.02 mSv/MBq, 0.17 ± 0.04 mSv/MBq and 0.23 ± 0.05 mSv/MBq for 191Pt-, 193mPt-, and 195mPt-cisplatin respectively. The combined effect of the radio- and chemotoxicity from 191Pt-cisplatin was investigated both in vitro and in vivo. A cervical cancer cell line was incubated with cisplatin or 191Pt-cisplatin with various concentrations and specific activities. It was shown that the surviving fraction was smaller for cells treated with 191Pt-cisplatin than for cells treated with the same concentration of non-radioactive cisplatin. The surviving fraction decreased with increasing specific activity. Isobologram technique showed that the radio- and chemotoxicity interacted in a supra-additive (synergistic) manner. In an in vivo model, nude mice with xenografted tumours were given physiological saline

  11. Durable donor engraftment after radioimmunotherapy using α-emitter astatine-211-labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation.

    Science.gov (United States)

    Chen, Yun; Kornblit, Brian; Hamlin, Donald K; Sale, George E; Santos, Erlinda B; Wilbur, D Scott; Storer, Barry E; Storb, Rainer; Sandmaier, Brenda M

    2012-02-01

    To reduce toxicity associated with external γ-beam radiation, we investigated radioimmunotherapy with an anti-CD45 mAb labeled with the α-emitter, astatine-211 ((211)At), as a conditioning regimen in dog leukocyte antigen-identical hematopoietic cell transplantation (HCT). Dose-finding studies in 6 dogs treated with 100 to 618 μCi/kg (211)At-labeled anti-CD45 mAb (0.5 mg/kg) without HCT rescue demonstrated dose-dependent myelosuppression with subsequent autologous recovery, and transient liver toxicity in dogs treated with (211)At doses less than or equal to 405 μCi/kg. Higher doses of (211)At induced clinical liver failure. Subsequently, 8 dogs were conditioned with 155 to 625 μCi/kg (211)At-labeled anti-CD45 mAb (0.5 mg/kg) before HCT with dog leukocyte antigen-identical bone marrow followed by a short course of cyclosporine and mycophenolate mofetil immunosuppression. Neutropenia (1-146 cells/μL), lymphopenia (0-270 cells/μL), and thrombocytopenia (1500-6560 platelets/μL) with prompt recovery was observed. Seven dogs had long-term donor mononuclear cell chimerism (19%-58%), whereas 1 dog treated with the lowest (211)At dose (155 μCi/kg) had low donor mononuclear cell chimerism (5%). At the end of follow-up (18-53 weeks), only transient liver toxicity and no renal toxicity had been observed. In conclusion, conditioning with (211)At-labeled anti-CD45 mAb is safe and efficacious and provides a platform for future clinical trials of nonmyeloablative transplantation with radioimmunotherapy-based conditioning. PMID:22134165

  12. 49 CFR 40.191 - What is a refusal to take a DOT drug test, and what are the consequences?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What is a refusal to take a DOT drug test, and what are the consequences? 40.191 Section 40.191 Transportation Office of the Secretary of Transportation PROCEDURES FOR TRANSPORTATION WORKPLACE DRUG AND ALCOHOL TESTING PROGRAMS Problems in Drug...

  13. Alpha particle angular distribution of oriented 189,191,193Bi

    International Nuclear Information System (INIS)

    Angular distribution data for α particles emitted in the enhanced decay of on-line oriented neutron deficient isotopes 189,191,193Bi near mid-shell (N=104) are presented. They give additional support for the recent finding that anisotropic α emission in enhanced decays from near-spherical nuclei is mainly determined by nuclear structure effects. (authors)

  14. 14 CFR 121.191 - Airplanes: Turbine engine powered: En route limitations: One engine inoperative.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Airplanes: Turbine engine powered: En route... Performance Operating Limitations § 121.191 Airplanes: Turbine engine powered: En route limitations: One engine inoperative. (a) No person operating a turbine engine powered airplane may take off that...

  15. 26 CFR 31.3121(b)(19)-1 - Services of certain nonresident aliens.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Services of certain nonresident aliens. 31.3121... 1954) General Provisions § 31.3121(b)(19)-1 Services of certain nonresident aliens. (a) (1) Services performed after 1961 by a nonresident alien individual who is temporarily present in the United States as...

  16. 19 CFR 191.155 - Merchandise withdrawn from warehouse for exportation.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Merchandise withdrawn from warehouse for... Custody § 191.155 Merchandise withdrawn from warehouse for exportation. The regulations in part 18 of this... from warehouse for exportation without payment of duty shall be followed to the extent applicable....

  17. Expression of symbiotic genes of Rhizobium japonicum USDA 191 in other rhizobia.

    OpenAIRE

    Appelbaum, E R; McLoughlin, T J; O'Connell, M.; Chartrain, N

    1985-01-01

    A 200-megadalton plasmid was mobilized from Rhizobium japonicum USDA 191 to other Rhizobium strains either that cannot nodulate soybeans or that form Fix- nodules on certain cultivars. The symbiotic properties of the transconjugants indicate that both soybean specificity for nodulation and cultivar specificity for nitrogen fixation are plasmid encoded.

  18. MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation

    International Nuclear Information System (INIS)

    Highlights: ► miR-191 expression is upregulated in senescencent human epidermal keratinocytes. ► miR-191 overexpression is sufficient per se to induce senescence in keratinocytes. ► SATB1 and CDK6 are downregulated in senescence and are direct miR-191 targets. ► SATB1 and CDK6 silencing by siRNA triggers senescence in HEKn cells. -- Abstract: Keratinocyte replicative senescence has an important role in time-dependent changes of the epidermis, a tissue with high turnover. Senescence encompasses growth arrest during which cells remain metabolically active but acquire a typical enlarged, vacuolar and flattened morphology. It is also accompanied by the expression of endogenous senescence-associated-β-galactosidase and specific gene expression profiles. MicroRNAs levels have been shown to be modulated during keratinocytes senescence, playing key roles in inhibiting proliferation and in the acquisition of senescent markers. Here, we identify miR-191 as an anti-proliferative and replicative senescence-associated miRNA in primary human keratinocytes. Its overexpression is sufficient per se to induce senescence, as evaluated by induction of several senescence-associated markers. We show that SATB1 and CDK6 3′UTRs are two miR-191 direct targets involved in this pathway. Cdk6 and Satb1 protein levels decrease during keratinocytes replicative senescence and their silencing by siRNA is able to induce a G1 block in cell cycle, accompanied by an increase in senescence-associated markers.

  19. 191不饱和树脂在油田固砂中的应用%Application of 191 unsaturated resin on sand consolidation in oil field

    Institute of Scientific and Technical Information of China (English)

    张国荣; 严锦根; 周秋霞; 王海翠; 王东; 李红; 衣秀惠

    2005-01-01

    研究了191不饱和聚酯树脂在油井上应用的配方.在35min时间内,固砂剂黏度小于4.5 Pa·s,能够满足现场安全施工的要求.其应用具有施工简单、防砂钻井时间短、防砂成功率高、有效期长、经济效益好等优点,值得推广.

  20. Neutron Induced Capture Cross Sections for Ir-191 and Ir-193

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Deok; Lee, Young Ouk [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2006-07-01

    The neutron induced cross sections are calculated on Ir- 191 and Ir-193 from 10 keV up to 20 MeV, on (n, tot), (n, n), (n, n'), (n, {gamma}), (n, p), (n, {alpha}), (n, 2n), (n, 3n), (n, np) and (n, n{alpha}) reactions. Iridium emits intense gamma rays. Specially, Ir-192 is the major gamma ray source material and widely used in the several areas: material assay, nondestructive testing and medical treatment. For the purpose of the above utilization, Ir-192 is mainly produced in the isotopic production nuclear reactor by the neutron capture process from Ir-191. Using threshold reaction with high energy of neutron, Ir-192 can be produced from Ir-194 by the process of the neutron capture and decay as well. Ir- 191 and Ir-193 have 37.3 % and 62.7 % respectively in the natural abundance. Ir-191 and 193 are stable isotopes. Ir-192 has 73.8 days half-life at ground state and 1.45 months at 56.7 keV meta stable state. Ir-192 has the beta decay to produce Pt-192 and the electron capture to produce Os-192. The major emitted gamma rays are 604 keV, 316 keV and 468 keV from the ground state decay. ENDF/B-VI has fairly recent evaluation on Ir-191 and Ir-193, evaluated in 1995 and distributed in 1997 (by R.Q.Wright, ORNL). From 2 to 20 MeV, the capture data was obtained by renormalizing the natural iridium capture to the Macklin data of Ir-191 at 2 MeV energy. ENDF/B-VI has the (n, 2n), (n, 3n), (n, p) and (n, a) cross section data unchanged from the BROND natural iridium evaluation. The evaluations consisted of an optical model potential search followed by a complete nuclear reaction model calculation and a validation for the experimental data. Nuclear reaction cross sections were calculated using the recently released Empire-II code. The direct capture model enhances the capture cross section in the preequilibrium energy region, and the width fluctuation correction influences on the capture and inelastic scattering cross sections in the equilibrium energy region. The

  1. Critical comments on the US Environmental Protection Agency Standards 40 CFR 191

    International Nuclear Information System (INIS)

    This paper is about the US Environmental Protection Agency (EPA) ''Environmental Standards for the Disposal of Spent Nuclear Fuel, High-Level and Transuranic Wastes,'' 40 CFR 191. These standards regulate the disposal of radioactive wastes in geologic repositories. Currently, two repository sites are under investigation: The Waste Isolation Pilot Plant (WIPP) site, located near Carlsbad, New Mexico, may become the repository for defense-generated transuranic waste (TRU); and the Yucca Mountain site, located near Las Vegas, Nevada, may become the repository for spent reactor fuel and a small amount of reprocessing waste (hereinafter called high-level radioactive waste or HLW). The paper was written for readers who have an interest in 40 CFR 191 but do not have the time or inclination to ponder the technical details

  2. Effect of arginine on stability of GST-ZNF191(243-368)

    Institute of Scientific and Technical Information of China (English)

    Dong Xin Zhao; Zhong Xian Huang

    2007-01-01

    For better understanding the chemical or biological information of ZNF191 (243-368), we expressed the fusion protein of GST and ZNF191(243-368), and used it to obtain the binding DNA sequence of this zinc finger protein. But in the process of expression and purification, we found this fusion protein slowly degradated. For resolving this problem, we simultaneously added charged amino acids L-Arg and L-Glu to the solution of fusion protein, and demonstrated that this method can dramatically increase the stability of this fusion protein. This method can make the fusion protein suitable for the continuous works, especially for situations where high protein concentration and long-term stability without precipitate and degradation of protein are required.

  3. The synthesis of 191Pt labelled JM216, an orally active platinum anti-tumour agent

    International Nuclear Information System (INIS)

    The orally active platinum anti-tumour complex JM 216 [bis-acetatoamminedichloro cyclohexylamineplatinum (IV)] is at present in stage II clinical trials. A procedure for synthesising the complex labelled with 191Pt or 188Pt at the platinum centre has been developed. The purity (shown by HPLC) is 98% and the specific activity (0.3-0.4 Ci/kg) is enough for in vivo and in vitro studies. (author)

  4. Novel genetic variants in miR-191 gene and familial ovarian cancer

    International Nuclear Information System (INIS)

    Half of the familial aggregation of ovarian cancer can't be explained by any known risk genes, suggesting the existence of other genetic risk factors. Some of these unknown factors may not be traditional protein encoding genes. MicroRNA (miRNA) plays a critical role in tumorigenesis, but it is still unknown if variants in miRNA genes lead to predisposition to cancer. Considering the fact that miRNA regulates a number of tumor suppressor genes (TSGs) and oncogenes, genetic variations in miRNA genes could affect the levels of expression of TSGs or oncogenes and, thereby, cancer risk. To test this hypothesis in familial ovarian cancer, we screened for genetic variants in thirty selected miRNA genes, which are predicted to regulate key ovarian cancer genes and are reported to be misexpressed in ovarian tumor tissues, in eighty-three patients with familial ovarian cancer. All of the patients are non-carriers of any known BRCA1/2 or mismatch repair (MMR) gene mutations. Seven novel genetic variants were observed in four primary or precursor miRNA genes. Among them, three rare variants were found in the precursor or primary precursor of the miR-191 gene. In functional assays, the one variant located in the precursor of miR-191 resulted in conformational changes in the predicted secondary structures, and consequently altered the expression of mature miR-191. In further analysis, we found that this particular variant exists in five family members who had ovarian cancer. Our findings suggest that there are novel genetic variants in miRNA genes, and those certain genetic variants in miRNA genes can affect the expression of mature miRNAs and, consequently, might alter the regulation of TSGs or oncogenes. Additionally, the variant might be potentially associated with the development of familial ovarian cancer

  5. Towards a standardised line list for G191-B2B, and other DA type objects

    CERN Document Server

    Preval, Simon P; Holberg, Jay B; Dickinson, N J

    2012-01-01

    We present a comprehensive analysis of the far UV spectrum of G191-B2B over the range of 900-1700{\\AA} using co-added data from the FUSE and STIS archives. While previous identifications made by Holberg et al. (2003) are reaffirmed in this work, it is found that many previously unidentified lines can now be attributed to Fe, Ni, and a few lighter metals. Future work includes extending this detailed analysis to a wider range of DA objects, in the expectation that a more complete analysis of their atmospheres can be realised.

  6. In-beam spectroscopy of very neutron deficient polonium isotopes 190,191Po

    International Nuclear Information System (INIS)

    The phenomenon of shape coexistence is experimentally well established in even-even light Pb, Hg and Pt nuclei. The light Po isotopes are predicted to exhibit similar features. Due to the experimental difficulties when approaching the proton drip-line, the lightest Po isotope for which in-beam γ-ray data exists prior this work has been 192Po. Since shape coexistence should be most pronounced at the neutron mid-shell (N=104), information about the excited states in lighter Po isotopes would be valuable in verifying the existence and possibly understanding the origin of the phenomenon in these nuclei. In the present work the recoil decay tagging method has been used to study excited states in the neutron deficient isotopes 190,191Po. Prompt γ-rays were detected with the Jurosphere Ge detector array coupled to the gas- filled separator RITU. The 191Po nuclei were produced in the 142Nd(52Cr,3n)191Po reaction at a bombarding energy of 240MeV. The observed prompt γ-rays correlated with the α-decay of the 191mPo 13/2+ state were placed in two cascades. Similar sequences have been observed in 193,195Po and presumably correspond to favoured and unfavoured states in the vi13 band. The unfavoured states are lowered below the favoured ones, resulting in a strongly coupled scheme which suggests oblate deformation. In a separate experiment the 142Nd(52Cr,4n)190Po reaction was used at higher beam energy. The production cross-section was approximately 200nb. Four prompt α-transitions correlated with the 190Po α-decay were observed and intepreted to form a cascade of E2 transitions up to spin 8+. In comparison to the heavier even Po isotopes, a drop in 6+ and 8+ energies is observed. This suggest an onset of prolate deformation in light Po isotopes as predicted by Oros et al. The results will be discussed in the framework of intruder states (author)

  7. Fission product yields from 19.1 MeV neutron induced fission of 238U

    International Nuclear Information System (INIS)

    36 chain yields were determined for the fission of 238U induced by 19.1 MeV neutrons for the first time. Absolute fission rate was monitored with a double-fission chamber. Fission product activities were measured by HPGe γ-ray spectrometry. Threshold detector method was used to measure the neutron spectrum in order to estimate the fission events induced by break-up neutrons and scattering neutrons. A mass distribution curve was obtained and the dependence of fission yield on neutron energy was discussed

  8. Yeast Interacting Proteins Database: YPR191W, YBL045C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YPR191W QC R2 Subunit 2 of the ubiquinol c ytoc hrome-c ... reduc tase c omplex, whic h is a c omponent of ... the mitoc hondrial inner membrane elec tron transport c hain; p ... hosphorylated; transc ription is regulated by Hap1p, Hap2p/Hap3p, and hem ... as bait (1) Rows with this bait as prey (2) YBL045C ... C OR1 C ore subunit of the ubiquinol-c ytoc hrome c ... re ... duc tase c omplex (bc 1 c omplex), whic h is a c omponent of ...

  9. Status of Waste Isolation Pilot Plant compliance with 40 CFR 191B, December 1992

    Energy Technology Data Exchange (ETDEWEB)

    Marietta, M.G.; Anderson, D.R.

    1993-10-01

    Before disposing of transuranic radioactive waste at the Waste Isolation Pilot Plant (WIPP), the US Department of Energy (DOE) must evaluate compliance with long-term regulations of the US Environmental Protection Agency (EPA). Sandia National Laboratories (SNL) is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for final compliance evaluations. This paper describes the 1992 preliminary comparison with Subpart B of the Environmental Standards for the Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191), which regulates long-term releases of radioactive waste. Results of the 1992 PA are preliminary, and cannot be used to determine compliance or noncompliance with EPA regulations because portions of the modeling system and data base are incomplete. Results are consistent, however, with those of previous iterations of PA, and the SNL WIPP PA Department has high confidence that compliance with 40 CFR 191B can be demonstrated. Comparison of predicted radiation doses from the disposal system also gives high confidence that the disposal system is safe for long-term isolation.

  10. The D/H Ratio in Interstellar Gas Towards G191-B2B

    CERN Document Server

    Sahu, M S; Bruhweiler, F C; Gull, T R; Bowers, C A; Lindler, D; Feggans, K; Barstow, M A; Hubeny, I; Holberg, J B

    1999-01-01

    We reinvestigate the question of spatial variation of the local D/H abundance, using both archival GHRS spectra, and new echelle spectra of G191-B2B obtained with the Space Telescope Imaging Spectrograph (STIS) aboard HST. Our analysis uses stratified line-blanketed non-LTE model atmosphere calculations to determine the shape of the intrinsic WD Lyman-alpha profile and estimate the WD photospheric contamination of the interstellar lines. Although three velocity components were reported previously towards G191-B2B, we detect only two velocity components. The first component is at V(hel) ~ 8.6 km/s and the second at V(hel) ~ 19.3 km/s, which we identify with the Local Interstellar Cloud (LIC). From the STIS data we derive D/H = 1.60(+0.39,-0.27)X10^-5 for the LIC component, and D/H > 1.26X10^-5 for the 8.6 km/s component (uncertainties denote 2-sigma or 95% confidence limits). The STIS data provide no evidence for local or component-to-component variation in the D/H ratio. Despite using two velocity components ...

  11. Status of Waste Isolation Pilot Plant compliance with 40 CFR 191B, December 1992

    International Nuclear Information System (INIS)

    Before disposing of transuranic radioactive waste at the Waste Isolation Pilot Plant (WIPP), the US Department of Energy (DOE) must evaluate compliance with long-term regulations of the US Environmental Protection Agency (EPA). Sandia National Laboratories (SNL) is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for final compliance evaluations. This paper describes the 1992 preliminary comparison with Subpart B of the Environmental Standards for the Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191), which regulates long-term releases of radioactive waste. Results of the 1992 PA are preliminary, and cannot be used to determine compliance or noncompliance with EPA regulations because portions of the modeling system and data base are incomplete. Results are consistent, however, with those of previous iterations of PA, and the SNL WIPP PA Department has high confidence that compliance with 40 CFR 191B can be demonstrated. Comparison of predicted radiation doses from the disposal system also gives high confidence that the disposal system is safe for long-term isolation

  12. The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis.

    Directory of Open Access Journals (Sweden)

    Fang Yang

    Full Text Available Ubiquitin E3 ligases target their substrates for ubiquitination, leading to proteasome-mediated degradation or altered biochemical properties. The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule proteolytic pathway, recognizes proteins with N-terminal destabilizing residues and plays an important role in spermatogenesis. Tex19.1 (also known as Tex19 has been previously identified as a germ cell-specific protein in mouse testis. Here we report that Tex19.1 forms a stable protein complex with Ubr2 in mouse testes. The binding of Tex19.1 to Ubr2 is independent of the second position cysteine of Tex19.1, a putative target for arginylation by the N-end rule pathway R-transferase. The Tex19.1-null mouse mutant phenocopies the Ubr2-deficient mutant in three aspects: heterogeneity of spermatogenic defects, meiotic chromosomal asynapsis, and embryonic lethality preferentially affecting females. In Ubr2-deficient germ cells, Tex19.1 is transcribed, but Tex19.1 protein is absent. Our results suggest that the binding of Ubr2 to Tex19.1 metabolically stabilizes Tex19.1 during spermatogenesis, revealing a new function for Ubr2 outside the conventional N-end rule pathway.

  13. Treatment of cultured glioma cells with the EGFR-TKI gefitinib (''Iressa'', ZD1839) increases the uptake of astatinated EGF despite the absence of gefitinib-mediated growth inhibition

    International Nuclear Information System (INIS)

    The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib (''Iressa'', ZD1839), a reversible growth inhibitor of EGFR-expressing tumour cells, has been shown to enhance the antitumour effect of ionising radiation, and also to increase the uptake of radioiodinated EGF. Thus, combination of gefitinib treatment and radionuclide targeting is an interesting option for therapy of brain tumours that are difficult to treat with conventional methods. The aim of this study was to evaluate how pre-treatment with gefitinib affects binding of astatinated EGF (211At-EGF) to cultured glioma U343 cells, which express high levels of EGFR. The growth of U343 cells in the presence of gefitinib was investigated, and it was found that gefitinib does not significantly inhibit the growth of these cells. Nevertheless, the uptake of 211At-EGF in U343 cells was markedly increased (up to 3.5 times) in cells pre-treated with gefitinib (1 μM). This indicates that a combination of gefitinib treatment and radionuclide targeting to EGFR might be a useful therapeutic modality, even for patients who do not respond to treatment with gefitinib alone. (orig.)

  14. Non-accidental injuries found in necropsies of domestic cats: a review of 191 cases.

    Science.gov (United States)

    de Siqueira, Adriana; Cassiano, Fabiana Cecília; de Albuquerque Landi, Marina Frota; Marlet, Elza Fernandes; Maiorka, Paulo César

    2012-10-01

    Animal cruelty is defined as a deliberate action that causes pain and suffering to an animal. In Brazil, legislation known as the Environmental Crimes Law states that cruelty toward all animal species is criminal in nature. From 644 domestic cats necropsied between January 1998 and December 2009, 191 (29.66%) presented lesions highly suggestive of animal cruelty. The main necroscopic finding was exogenous carbamate poisoning (75.39%) followed by blunt-force trauma (21.99%). Cats from 7 months to 2 years of age were the most affected (50.79%). In Brazil, violence is a public health problem and there is a high prevalence of domestic violence. Therefore, even if laws provide for animal welfare and protection, animals are common targets for violent acts. Within a context of social violence, cruelty toward animals is an important parameter to be considered, and the non-accidental lesions that were found are evidence of malicious actions. PMID:22694958

  15. Electromagnetic properties of low-excitation states in 191Ir and 193Ir and supersymmetry schemes

    International Nuclear Information System (INIS)

    The electromagnetic properties of low-excitation states in 191Ir and 193Ir have been studied following Coulomb excitation. Gyromagnetic ratios were measured by the transient-field technique and level lifetimes were measured by the Doppler-shift recoil distance method. Multipolarity mixing ratios were determined from measured particle-γ angular correlations. The present lifetime and g-factor results extend the data available for comparison with theory and help discriminate between disparate experimental values reported previously in the literature. We compare the experimental data with particle-triaxial-rotor model calculations and with the predictions of the U(6/4) and U(6/20) supersymmetry models based on the interacting-boson-fermion model

  16. Nuclear orientation of 188-189Ir and 189-191Pt

    International Nuclear Information System (INIS)

    188-189Ir and 189-191Pt have been oriented at low temperature in the hyperfine magnetic field in iron. Precise energy measurements of some high-energy gamma rays in the disintegration of 188Ir have also been performed, resulting in the modification of the high-energy level scheme of 188Os. In the daughter nuclei spins and parities of excited states and multiple mixing ratios of transitions are established. For some non-unique electron-capture transitions jsub(β) = O/jsub(β) = 1 intensity ratios are also deduced. Results are analysed in terms of mixed psub(3/2) and fsub(5/2) configurations in the neutron shell. (author)

  17. 19 CFR 191.36 - Failure to file Notice of Intent to Export, Destroy, or Return Merchandise for Purposes of Drawback.

    Science.gov (United States)

    2010-04-01

    ...) Export period covered by this application; (D) Commodity/product lines of imported and exported... between the parties involved in the import and export transactions; (ii) Written declarations regarding..., Destroy, or Return Merchandise for Purposes of Drawback. 191.36 Section 191.36 Customs Duties U.S....

  18. Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice

    DEFF Research Database (Denmark)

    Ollinger, Rupert; Childs, Andrew J; Burgess, Hannah M;

    2008-01-01

    . During male spermatogenesis, Tex19.1 expression is highest in mitotic spermatogonia and diminishes as these cells differentiate and progress through meiosis. In pluripotent stem cells, Tex19.1 expression is also downregulated upon differentiation. However, it is not clear whether Tex19.1 has an essential...... spermatogenesis. Immunostaining and histological analysis revealed defects in meiotic chromosome synapsis, the persistence of DNA double-strand breaks during meiosis, and a loss of post-meiotic germ cells in the testis. Furthermore, expression of a class of endogenous retroviruses is upregulated during meiosis in...... the Tex19.1(-/-) testes. Increased transposition of endogenous retroviruses in the germline of Tex19.1(-/-) mutant mice, and the concomitant increase in DNA damage, may be sufficient to disrupt the normal processes of recombination and chromosome synapsis during meiosis and cause defects in...

  19. k191yb.m77t and k191yb.h77t: MGD77T data and header files for single-beam bathymetry data for field activity K-1-91-YB in Yakutat Bay, Alaska from 06/22/1991 to 06/28/1991

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Single-beam bathymetry data along with radar and GPS navigation data was collected as part of the U.S. Geological Survey cruise K-1-91-YB. The cruise was conducted...

  20. Mortality in 191 counties near energy facilities: use of economic and social variables for standardization

    International Nuclear Information System (INIS)

    Standardization of mortality for variation in sociodemographic characteristics as well as for age, sex, and race is required for improved detection of changes in mortality around point sources of pollution. Mortality by level and selected causes was studied in 191 counties within 80 km of 15 power generation sites chosen to represent the diversity of US socioeconomic, demographic, and geographic features. Mortality data for 1969 to 1971 were evaluated against selected 1970 US census, air pollution, climate, and cigarette and beer consumption data. A mortality process scheme was developed and used to rationalize the selection of independent variables. Applying this technique to regressions of mortality on air pollution and social-demographic variables, only female mortality was found to have strong independent or interactive effects with air pollution. For cause-specific mortality, the explained variance was small for diseases with major genetic components and larger for diseases with strong socioeconomic components. Testing of the regression equations indicated that standardization for socioeconomic factors may be a useful strategy on a regional basis

  1. Spectrum of {gamma} rays from the decay of SD to normal states in {sup 191}Hg

    Energy Technology Data Exchange (ETDEWEB)

    Gassmann, D.; Khoo, T.L.; Lauritsen, T. [and others

    1995-08-01

    In B.a.7. we propose that the statistical spectrum emitted from a sharp single excited state serves as a probe of pairing in excited states. A specific test of this proposal is the comparison of the spectra from even-even and odd-even nuclei. Whereas a pair gap exists in an even-even nucleus, it gets filled in an odd-even nucleus. Consequently, low-energy transitions can arise in the latter case, whereas they are calculated to be absent in the former case because very few levels exist in the cold gap region. In addition, transitions between 1.4 - 2.2 MeV, which {open_quotes}jump{close_quotes} across the gap, are predicted to have lower yield in the odd-even nuclei. Serendipitously, decay from a superdeformed state serves as a good initial excited sharp state. We extracted the spectrum pairwise-coincident with SD lines in {sup 191}Hg from Gammasphere data and compared it with the equivalent spectra from the even-even nuclei {sup 192,194}Hg. The differences that are predicted to occur are indeed observed. Thus, the data support our proposal that the reduction of pairing with thermal excitation energy can be probed with statistical decay spectra.

  2. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    The Waste Isolation Pilot Plant (WIPP) is a research and development facility for the demonstration of the permanent isolation of transuranic radioactive wastes in a geologic formation. The facility was constructed in southeastern New Mexico in a manner intended to meet criteria established by the scientific and regulatory community for the safe, long-term disposal of transuranic wastes. The US Department of Energy (DOE) is preparing an application to demonstrate compliance with the requirements outlined in Title 40, Part 191 of the Code of Federal Regulations (CFR) for the permanent disposal of transuranic wastes. As mandated by the Waste Isolation Pilot Plant (WIPP) Land Withdrawal Act of 1992, the US Environmental Protection Agency (EPA) must evaluate this compliance application and provide a determination regarding compliance with the requirements within one year of receiving a complete application. Because the WIPP is a very complex program, the DOE has planned to submit the application as a draft in two parts. This strategy will allow for the DOE and the EPA to begin technical discussions on critical WIPP issues before the one-year compliance determination period begins. This report is the first of these two draft submittals.

  3. ALMA observations of cold molecular gas filaments trailing rising radio bubbles in PKS 0745-191

    Science.gov (United States)

    Russell, H. R.; McNamara, B. R.; Fabian, A. C.; Nulsen, P. E. J.; Edge, A. C.; Combes, F.; Murray, N. W.; Parrish, I. J.; Salomé, P.; Sanders, J. S.; Baum, S. A.; Donahue, M.; Main, R. A.; O'Connell, R. W.; O'Dea, C. P.; Oonk, J. B. R.; Tremblay, G.; Vantyghem, A. N.; Voit, G. M.

    2016-05-01

    We present ALMA observations of the CO(1-0) and CO(3-2) line emission tracing filaments of cold molecular gas in the central galaxy of the cluster PKS 0745-191. The total molecular gas mass of 4.6± 0.3× 109 M_{⊙}, assuming a Galactic XCO factor, is divided roughly equally between three filaments each extending radially 3-5 kpc from the galaxy centre. The emission peak is located in the SE filament ˜ 1 arcsec (2 kpc) from the nucleus. The velocities of the molecular clouds in the filaments are low, lying within ± 100 { km s^{-1}} of the galaxy's systemic velocity. Their full width at half-maximum (FWHM) are less than 150 { km s^{-1},} which is significantly below the stellar velocity dispersion. Although the molecular mass of each filament is comparable to a rich spiral galaxy, such low velocities show that the filaments are transient and the clouds would disperse on bright optical line emission and dust lanes indicating that the molecular gas could have formed from lifted warmer gas that cooled in situ.

  4. ALMA observations of cold molecular gas filaments trailing rising radio bubbles in PKS0745-191

    CERN Document Server

    Russell, H R; Fabian, A C; Nulsen, P E J; Edge, A C; Combes, F; Murray, N W; Parrish, I J; Salome, P; Sanders, J S; Baum, S A; Donahue, M; Main, R A; O'Connell, R W; O'Dea, C P; Oonk, J B R; Tremblay, G; Vantyghem, A N; Voit, G M

    2016-01-01

    We present ALMA observations of the CO(1-0) and CO(3-2) line emission tracing filaments of cold molecular gas in the central galaxy of the cluster PKS0745-191. The total molecular gas mass of 4.6 +/- 0.3 x 10^9 solar masses, assuming a Galactic X_{CO} factor, is divided roughly equally between three filaments each extending radially 3-5 kpc from the galaxy centre. The emission peak is located in the SE filament roughly 1 arcsec (2 kpc) from the nucleus. The velocities of the molecular clouds in the filaments are low, lying within +/-100 km/s of the galaxy's systemic velocity. Their FWHMs are less than 150 km/s, which is significantly below the stellar velocity dispersion. Although the molecular mass of each filament is comparable to a rich spiral galaxy, such low velocities show that the filaments are transient and the clouds would disperse on <10^7 yr timescales unless supported, likely by the indirect effect of magnetic fields. The velocity structure is inconsistent with a merger origin or gravitational ...

  5. ALMA observations of cold molecular gas filaments trailing rising radio bubbles in PKS 0745-191

    Science.gov (United States)

    Russell, H. R.; McNamara, B. R.; Fabian, A. C.; Nulsen, P. E. J.; Edge, A. C.; Combes, F.; Murray, N. W.; Parrish, I. J.; Salomé, P.; Sanders, J. S.; Baum, S. A.; Donahue, M.; Main, R. A.; O'Connell, R. W.; O'Dea, C. P.; Oonk, J. B. R.; Tremblay, G.; Vantyghem, A. N.; Voit, G. M.

    2016-05-01

    We present ALMA observations of the CO(1-0) and CO(3-2) line emission tracing filaments of cold molecular gas in the central galaxy of the cluster PKS 0745-191. The total molecular gas mass of 4.6± 0.3× 109 M_{⊙}, assuming a Galactic XCO factor, is divided roughly equally between three filaments each extending radially 3-5 kpc from the galaxy centre. The emission peak is located in the SE filament ˜ 1 arcsec (2 kpc) from the nucleus. The velocities of the molecular clouds in the filaments are low, lying within ± 100 { km s^{-1}} of the galaxy's systemic velocity. Their full width at half-maximum (FWHM) are less than 150 { km s^{-1},} which is significantly below the stellar velocity dispersion. Although the molecular mass of each filament is comparable to a rich spiral galaxy, such low velocities show that the filaments are transient and the clouds would disperse on observed. Instead, the projection of the N and SE filaments underneath X-ray cavities suggests they formed in the updraft behind bubbles buoyantly rising through the cluster atmosphere. Direct uplift of the dense gas by the radio bubbles appears to require an implausibly high coupling efficiency. The filaments are coincident with low temperature X-ray gas, bright optical line emission and dust lanes indicating that the molecular gas could have formed from lifted warmer gas that cooled in situ.

  6. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 1

    International Nuclear Information System (INIS)

    The Waste Isolation Pilot Plant (WIPP) is a research and development facility for the demonstration of the permanent isolation of transuranic radioactive wastes in a geologic formation. The facility was constructed in southeastern New Mexico in a manner intended to meet criteria established by the scientific and regulatory community for the safe, long-term disposal of transuranic wastes. The US Department of Energy (DOE) is preparing an application to demonstrate compliance with the requirements outlined in Title 40, Part 191 of the Code of Federal Regulations (CFR) for the permanent disposal of transuranic wastes. As mandated by the Waste Isolation Pilot Plant (WIPP) Land Withdrawal Act of 1992, the US Environmental Protection Agency (EPA) must evaluate this compliance application and provide a determination regarding compliance with the requirements within one year of receiving a complete application. Because the WIPP is a very complex program, the DOE has planned to submit the application as a draft in two parts. This strategy will allow for the DOE and the EPA to begin technical discussions on critical WIPP issues before the one-year compliance determination period begins. This report is the first of these two draft submittals

  7. Implementation of the Resource Disincentive in 40 CFR part 191.14 (e) at the Waste Isolation Pilot Plant

    International Nuclear Information System (INIS)

    In 1986, the US Department of Energy (DOE) Waste Isolation Pilot Plant (WIPP) Project Office (WPO) (DOE-WPO) prepared a strategy for complying with the Environmental Protection Agency's (EPA's) Standards for the management of transuranic (TRU) waste. Section 3.2.2.2 of the DOE's report addressed compliance with the Assurance Requirements found in 40 CFR section 191.14. One of the Assurance Requirements addresses the selection of repository sites that contain recoverable natural resources. This report documents that the site selection process for the WIPP facility did indeed comply with the natural resource disincentive requirement in 40 CFR section 191,14(e) at the time selected and therefore complies with the standard at this time. Thus, it shall be shown that it is reasonably certain that the WIPP site provides better overall protection than practical alternatives that were available when the site was selected. It is important to point out here, and it will be discussed later in the report, that the resource disincentive requirement is a preliminary siting criterion that requires further evaluation of sites that have resources (i.e, hydrocarbons, minerals and groundwater) in the vicinity or on the site. This further evaluation requires that for sites that do have resources, a qualitative determination must be made that the site will provide better overall protection than practical alternatives. The purpose of this report is not to provide a quantitative evaluation for selection of the WIPP site. A further discussion on the difference between the qualitative analysis required under 40 CFR section 191.14(e) and the quantitative analysis under other sections of 40 CFR 191 is provided in section 2.1 of this report

  8. Preliminary comparison with 40 CFR Part 191, Subpart B for the Waste Isolation Pilot Plant, December 1990

    International Nuclear Information System (INIS)

    The Waste Isolation Pilot Plant (WIPP) is planned as the first mined geologic repository for transuranic (TRU) wastes generated by defense programs of the United States Department of Energy (DOE). Before disposing of waste at the WIPP, the DOE must evaluate compliance with the United states Environmental Protection Agency's (EPA) Standard, Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR Part 191, US EPA, 1985). Sandia National Laboratories (SNL) is evaluating long-term performance against criteria in Subpart B of the Standard. ''Performance assessment'' as used in this report includes analyses for the Containment Requirements (section 191.13(a)) and the Individual Protection Requirements (section 191.15). Because proving predictions about future human actions or natural events is not possible, the EPA expects compliance to be determined on the basis of specified quantitative analyses and informed, qualitative judgment. The goal of the WIPP performance-assessment team at SNL is to provide as detailed and thorough a basis as practical for the quantitative aspects of that decision. This report summarizes SNL's late-1990 understanding of the WIPP Project's ability to evaluate compliance with Subpart B. 245 refs., 88 figs., 23 tabs

  9. Preliminary comparison with 40 CFR Part 191, Subpart B for the Waste Isolation Pilot Plant, December 1990

    Energy Technology Data Exchange (ETDEWEB)

    Bertram-Howery, S.G.; Marietta, M.G.; Rechard, R.P.; Anderson, D.R. (Sandia National Labs., Albuquerque, NM (USA)); Swift, P.N. (Tech. Reps., Inc., Albuquerque, NM (USA)); Baker, B.L. (Technadyne Engineering Consultants, Inc., Albuquerque, NM (USA)); Bean, J.E. Jr.; McCurley, R.D.; Rudeen, D.K. (New Mexico Engineering Research Inst., Albuquerque, NM (USA)); Beyeler, W.; Brinster, K.F.; Guzowski, R.V.; Sch

    1990-12-01

    The Waste Isolation Pilot Plant (WIPP) is planned as the first mined geologic repository for transuranic (TRU) wastes generated by defense programs of the United States Department of Energy (DOE). Before disposing of waste at the WIPP, the DOE must evaluate compliance with the United states Environmental Protection Agency's (EPA) Standard, Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR Part 191, US EPA, 1985). Sandia National Laboratories (SNL) is evaluating long-term performance against criteria in Subpart B of the Standard. Performance assessment'' as used in this report includes analyses for the Containment Requirements ({section} 191.13(a)) and the Individual Protection Requirements ({section} 191.15). Because proving predictions about future human actions or natural events is not possible, the EPA expects compliance to be determined on the basis of specified quantitative analyses and informed, qualitative judgment. The goal of the WIPP performance-assessment team at SNL is to provide as detailed and thorough a basis as practical for the quantitative aspects of that decision. This report summarizes SNL's late-1990 understanding of the WIPP Project's ability to evaluate compliance with Subpart B. 245 refs., 88 figs., 23 tabs.

  10. Evidence for binarity in the bipolar planetary nebulae A79, He2-428 and M1-91

    CERN Document Server

    Rodríguez, M; Mampaso, A

    2001-01-01

    We present low and high resolution long-slit spectra of three bipolar planetary nebulae (PNe) with bright central cores: A79, He2-428 and M1-91. He2-428 and M1-91 have high density (from 10^3.3 to 10^6.5 cm^-3) unresolved nebular cores that indicate that strong mass loss/exchange phenomena are occurring close to their central stars. An F0 star is found at the centre of symmetry of A79; its reddening and distance are consistent with the association of the star with the nebula. The spectrum of the core of He2-428 shows indications of the presence of a hot star with red excess emission, probably arising in a late-type companion. A79 is one of the richest PNe in N and He, the abundances of M1-91 are at the lower end of the range spanned by bipolar PNe, and He2-428 shows very low abundances, similar to those measured for halo PNe. The extended nebulae of A79 and He2-428 have inclined equatorial rings expanding at a velocity of approx. 15 km/s, with kinematical ages 10^4 yr. The association of these aged, extended ...

  11. A Title 40 Code of Federal Regulations Part 191 Evaluation of Buried Transuranic Waste at the Nevada Test Site

    International Nuclear Information System (INIS)

    In 1986, 21 m3 of transuranic (TRU) waste was inadvertently buried in a shallow land burial trench at the Area 5 Radioactive Waste Management Site on the Nevada Test Site (NTS). The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office is considered five options for management of the buried TRU waste. One option is to leave the waste in-place if the disposal can meet the requirements of Title 40 Code of Federal Regulations (CFR) Part 191, 'Environmental Radiation Protection Standard for Management and Disposal of Spent Nuclear Fuel, High-Level, and Transuranic Radioactive Wastes'. This paper describes analyses that assess the likelihood that TRU waste in shallow land burial can meet the 40 CFR 191 standards for a geologic repository. The simulated probability of the cumulative release exceeding 1 and 10 times the 40 CFR 191.13 containment requirements is estimated to be 0.009 and less than 0.0001, respectively. The cumulative release is most sensitive to the number of groundwater withdrawal wells drilled through the disposal trench. The mean total effective dose equivalent for a member of the public is estimated to reach a maximum of 0.014 milli-Sievert (mSv) at 10,000 years, or approximately 10 percent of the 0.15 mSv 40 CFR 191.15 individual protection requirement. The dose is predominantly from inhalation of short-lived Rn-222 progeny in air produced by low-level waste disposed in the same trench. The transuranic radionuclide released in greatest amounts, Pu-239, contributes only 0.4 percent of the dose. The member of public dose is most sensitive to the U-234 inventory and the radon emanation coefficient. Reasonable assurance of compliance with the Subpart C groundwater protection standard is provided by site characterization data and hydrologic processes modeling which support a conclusion of no groundwater pathway within 10,000 years. Limited quantities of transuranic waste in a shallow land burial trench at the NTS can meet

  12. 191例创伤性颅脑损伤流行病学特征分析%An Analysis on Epidemiological Characteristics of 191 Patients with Traumatic Brain Injury

    Institute of Scientific and Technical Information of China (English)

    左永明; 蒲云学

    2011-01-01

    Objective: To investigate the epidemiological characteristics of 191 patients with trauma tic brain injury (TBI), and to provide evidences for developing reasonable prevention and management policy of this disease. Methods: Age, gender, injury time, season, region and cause of injury of 191 TBI cases were analyzed with descriptive epidemiological method. Results: There were more male TBI cases than female cases. TBI happened mainly in people between 30 to 60 years old. Farmers and migrant workers were easier to be injured. Injury occurred predominantly in activity concentrated period during the day. The incidences in undeveloped countryside and connecting areas of city and countryside were much higher than those in urban areas. More and more TBI were caused by traffic accidents.Conclusions: The occurrence rate of TBI is increasing gradually year by year. Integrated measures should be taken to reduce injury accident from the source.%目的:分析191例创伤性颅脑损伤的流行病学特征,为预防和减少创伤性颅脑损伤提供参考.方法:采用描述流行病学的方法,对191例创伤性颅脑损伤病例的年龄、性别、受伤时间、季节、地区、职业及受伤原因进行分析.结果:创伤性颅脑损伤病例男性高于女性,以30~60岁发病为主,农民或农民工等群体发病率高,受伤时间主要发生在活动较为集中的时间段;经济不发达的农村和城乡结合部发病较严重,交通事故导致颅脑损伤较多.结论:创伤性颅脑损伤发生率有逐年上升趋势,应从致伤源头采取综合措施减少创伤性颅脑损伤的发生.

  13. Considerations for guidance for radioactive waste disposal arising from rules under 40 CFR 191 and 40 CFR 194

    International Nuclear Information System (INIS)

    Preliminary performance assessments (PAs) have been conducted for the Waste Isolation Pilot Plant (WIPP) in southeastern New Mexico. These PAs assess the ability of the WIPP, a proposed disposal facility for defense-generated nuclear waste, to comply with EPA's requirements at 40 CFR 191. The experience in conducting PAs has provided insights into guidance that would facilitate the conduct of studies and analyses required by the regulation. Guidance topics and suggested directions are discussed for possible inclusion in EPA rulemaking for WIPP-specific compliance criteria to be found at 40 CFR 194

  14. CIRCUMSTANŢELE AGRAVANTE PREVĂZUTE LA lit.b ŞI d alin.(2 ŞI LA alin.(3 art.191 CP RM

    Directory of Open Access Journals (Sweden)

    Irina SELEVESTRU

    2016-03-01

    Full Text Available În rezultatul investigaţiei efectuate, se stabileşte că circumstanţa agravantă consemnată la lit.b alin.(2 art.191 CP RM nu este operaţională în următoarele două ipoteze: a infracţiunea prevăzută la alin.(1 art.191 CP RM este săvârşită de o persoană având calitatea specială de administrator, împreună cu o persoană care nu are o asemenea calitate; b infrac­ţiunea este comisă de o persoană având calitatea specială de administrator, prin intermediul unei persoane care nu are o astfel de calitate. Se relevă că, în situaţia în care decizia, care contravine dispoziţiei alin.(1 art.191 CP RM, este adoptată de doi sau mai mulţi membri ai unui organism decizional colegial, apare temeiul aplicării lit.b alin.(2 art.191 CP RM. Se arată că va răspunde în calitate de organizator, instigator sau complice la infracţiunea prevăzută la lit.d alin.(2 art.191 CP RM acea persoană: a căreia îi lipseşte fie cea de-a doua calitate specială nominalizată mai sus, fie ambele calităţi speciale menţionate supra şi b care a luat parte la comiterea respectivei infracţiuni. Se demonstrează că art.327 sau 335 CP RM ori art.312 din Codul contravenţional nu pot fi aplicate în ipoteza în care infracţiunea prevăzută la alin.(1 art.191 CP RM este săvârşită cu folosirea situaţiei de serviciu. THE AGGRAVATING CIRCUMSTANCES REFFERED TO AT lett.b AND d par.(2 AND par.(3 OF art.191 PC RMAs a result of the conducted investigation, it is established that the aggravating circumstance under lett.b par.(2 art.191 PC RM does not work in the following two assumptions: a the offence referred to at par.(1 art.191 PC RM is committed by a person with the special quality of manager, together with a person who does not have such a quality; b the offence is committed by a person with the special quality of manager, through a mediator who does not have such a quality. It is shown that, if the decision – contrary to par.(1 art

  15. Long-lived three-quasiparticle isomers in {sup 191}Ir and {sup 193}Ir with triaxial deformation

    Energy Technology Data Exchange (ETDEWEB)

    Dracoulis, G.D., E-mail: george.dracoulis@anu.edu.au [Department of Nuclear Physics, R.S.P.E., Australian National University, Canberra, A.C.T. 0200 (Australia); Lane, G.J.; Byrne, A.P. [Department of Nuclear Physics, R.S.P.E., Australian National University, Canberra, A.C.T. 0200 (Australia); Watanabe, H. [Department of Nuclear Physics, R.S.P.E., Australian National University, Canberra, A.C.T. 0200 (Australia); RIKEN Nishina Center, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Hughes, R.O.; Palalani, N. [Department of Nuclear Physics, R.S.P.E., Australian National University, Canberra, A.C.T. 0200 (Australia); Kondev, F.G. [Nuclear Engineering Division, Argonne National Laboratory, Argonne IL (United States); Carpenter, M.; Janssens, R.V.F.; Lauritsen, T.; Lister, C.J.; Seweryniak, D.; Zhu, S. [Physics Division, Argonne National Laboratory, Argonne IL (United States); Chowdhury, P. [Department of Physics, University of Massachusetts Lowell, Lowell, MA 01854 (United States); Shi, Y.; Xu, F.R. [School of Physics, Peking University, Beijing 100871 (China)

    2012-03-13

    Deep-inelastic reactions have been used to populate high-spin states in the iridium isotopes. New results include the identification of particularly long-lived three-quasiparticle isomers in {sup 191}Ir and {sup 193}Ir, with mean-lives of 8.2(7) s and 180(3) {mu}s respectively, decaying into newly identified states of the h{sub 11/2} proton bands and into other structures. Spins and parities of J{sup {pi}}=31/2{sup +} are suggested for both, consistent with coupling of the 11/2{sup -}[505] proton to the 10{sup -}two-neutron excitations in the cores. These and other configurations are discussed in the context of configuration constrained potential-energy-surface calculations. All calculated intrinsic states are expected to be associated with triaxial shapes and the extreme isomerism observed is attributed to spin-trapping rather than K-hindrance.

  16. Derivation of airfoil characteristics for the LM 19.1 blade based on 3D CFD rotor calculations

    Energy Technology Data Exchange (ETDEWEB)

    Bak, C.; Soerensen, N.N.; Madsen, H.A. [Risoe National Lab., Roskilde (Denmark)

    1999-03-01

    Airfoil characteristics for the LM 19.1 blade are derived from 3D CFD computations on a full-scale 41-m rotor. Based on 3D CFD the force distributions on the blades are determined, from which airfoil characteristics are derived using the momentum theory. The final airfoil characteristics are constructed using both wind tunnel measurements and 3D CFD. Compared to 2D wind tunnel measurements they show a low lift in stall for the airfoil sections at the tip. At the airfoil sections at the inner part of the blade, they show a high lift in stall. At about 60% radius the lift agrees well to 2D wind tunnel measurements. Aero-elastic calculations using the final airfoil characteristics show good agreement to measured power and flap moments. Furthermore, a fatigue load analysis shows a reduction of up to 15% of the load compared to commonly used data. (au)

  17. 75 FR 43813 - Modification of VOR Federal Airways V-82, V-175, V-191, and V-430 in the Vicinity of Bemidji, MN

    Science.gov (United States)

    2010-07-27

    ... modify V-82, V-175, V-191, and V-430 in the vicinity of Bemidji, MN (75 FR 24504). Interested parties... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a regulatory evaluation...: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p.389....

  18. On the Diophantine Equation x3 -1=91 y2%关于Diophantine方程x3-1=91 y2

    Institute of Scientific and Technical Information of China (English)

    钱立凯; 普粉丽

    2015-01-01

    Using the elementary methods,it was proved that the Diophantine equation x3 -1=91y2 has only trivial solution.%利用初等方法证明了Diophantine方程x3-1=91y2仅有整数解( x,y)=(1,0)。

  19. Speeding up the product release: a second-sphere contribution from Tyr191 to the reactivity of L-lactate oxidase revealed in crystallographic and kinetic studies of site-directed variants.

    Science.gov (United States)

    Stoisser, Thomas; Klimacek, Mario; Wilson, David K; Nidetzky, Bernd

    2015-11-01

    Among α-hydroxy acid-oxidizing flavoenzymes l-lactate oxidase (LOX) is unique in featuring a second-sphere tyrosine (Tyr191 in Aerococcus viridans LOX; avLOX) at the binding site for the substrate's carboxylate group. Y191F, Y191L and Y191A variants of avLOX were constructed to affect a hydrogen-bond network connecting Tyr191 to the carboxylate of the bound ligand via the conserved Tyr40 and to examine consequent effects on enzymatic reactivity. Kinetic studies at 20 °C and pH 6.5 revealed that release of pyruvate product was decreased 4.7-fold (Y191F), 19-fold (Y191L) and 28-fold (Y191A) compared with wild-type enzyme (~ 141 s(-1)) and thus became mainly rate limiting for l-lactate oxidation by the variants at a steady-state under air-saturated conditions. In the Y191L and the Y191A variants, but not in the Y191F variant, l-lactate binding was also affected strongly by the site-directed substitution. Reduction of the flavin cofactor by l-lactate and its reoxidation by molecular oxygen were, however, comparatively weakly affected by the replacements of Tyr191. Unlike the related lactate monooxygenase, which prevents the fast dissociation of pyruvate to promote its oxidative decarboxylation by H2 O2 into acetate, CO2 and water as final reaction products, all avLOX variants retained their native oxidase activity where catalytic turnover results in the equivalent formation of H2O2. The 1.9 Å crystal structure of the Y191F variant bound with FMN and pyruvate revealed a strictly locally disruptive effect of the site-directed substitution. Product off-rates appear to be dictated by partitioning of residues including Tyr191 from an active-site lid loop into bulk solvent and modulation of the hydrogen bond strength that links Tyr40 with the pyruvate's carboxylate group. Overall, this study emphasizes the possibly high importance of contributions from second-sphere substrate-binding residues to the fine-tuning of reactivity in α-hydroxy acid-oxidizing flavoenzymes

  20. Astatination of closo-dodecaborate(2-) anion

    Czech Academy of Sciences Publication Activity Database

    Orlova, A.; Lebeda, Ondřej; Tolmachev, V.; Lundquist, H.; Carlsson, J.; Sjöberg, S.

    Cambridge : The Royal Society of Chemistry , 2000 - (Davidson, M.; Hughes, A.; Marder, T.; Wade , K.), s. 144-147 [Conference "Contemporary Boron Chemistry ". Durham (GB), 11.07.1999-15.07.1999] Institutional research plan: CEZ:AV0Z1048901 Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  1. Six Years of Experience in Photodynamic Therapy for Basal Cell Carcinoma: Results and Fluorescence Diagnosis from 191 Lesions

    Directory of Open Access Journals (Sweden)

    M. Fernández-Guarino

    2014-01-01

    Full Text Available Background. Photodynamic therapy (PDT has become a therapeutic option for basal cell carcinoma (BCC in the last decade. Objectives. To study the results and predictors of BCC response to treatment with PDT and to evaluate fluorescence diagnosis of BCC. Methods. A descriptive, retrospective, and observational study was carried out. Patients with biopsy-confirmed BCC who were treated with methyl aminolevulinate and red light according to standard treatment protocols (2 sessions separated by 2 weeks, 630 nm, 37 J/cm2, 8 minutes, Aktilite were selected. Response was scored as clinically complete and incomplete and the patients were followed up every three months. Results. Data from 191 BCC in 181 patients with a mean age of 69.55 years and a mean follow-up period of 34.4 months were collected. The overall response was 74% of the BCC treated, with the best response in superficial BCC with a 95% of complete response. The regression analysis revealed that the superficial histological type was the primary factor predictive of a complete response. Conclusions. In the treatment of BCC with PDT, the most significant factor for predicting response is the histological type.

  2. Implementation of the Resource Disincentive in 40 CFR part 191.14 (e) at the Waste Isolation Pilot Plant. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    In 1986, the US Department of Energy (DOE) Waste Isolation Pilot Plant (WIPP) Project Office (WPO) (DOE-WPO) prepared a strategy for complying with the Environmental Protection Agency`s (EPA`s) Standards for the management of transuranic (TRU) waste. Section 3.2.2.2 of the DOE`s report addressed compliance with the Assurance Requirements found in 40 CFR {section} 191.14. One of the Assurance Requirements addresses the selection of repository sites that contain recoverable natural resources. This report documents that the site selection process for the WIPP facility did indeed comply with the natural resource disincentive requirement in 40 CFR {section} 191,14(e) at the time selected and therefore complies with the standard at this time. Thus, it shall be shown that it is reasonably certain that the WIPP site provides better overall protection than practical alternatives that were available when the site was selected. It is important to point out here, and it will be discussed later in the report, that the resource disincentive requirement is a preliminary siting criterion that requires further evaluation of sites that have resources (i.e, hydrocarbons, minerals and groundwater) in the vicinity or on the site. This further evaluation requires that for sites that do have resources, a qualitative determination must be made that the site will provide better overall protection than practical alternatives. The purpose of this report is not to provide a quantitative evaluation for selection of the WIPP site. A further discussion on the difference between the qualitative analysis required under 40 CFR {section} 191.14(e) and the quantitative analysis under other sections of 40 CFR 191 is provided in {section}2.1 of this report.

  3. Draft forecast of the final report for the comparison to 40 CFR Part 191, Subpart B, for the Waste Isolation Pilot Plant

    Energy Technology Data Exchange (ETDEWEB)

    Bertram-Howery, S.G.; Marietta, M.G.; Anderson, D.R.; Gomez, L.S.; Rechard, R.P. (Sandia National Labs., Albuquerque, NM (USA)); Brinster, K.F.; Guzowski, R.V. (Science Applications International Corp., Albuquerque, NM (USA))

    1989-12-01

    The United States Department of Energy is planning to dispose of transuranic wastes, which have been generated by defense programs, at the Waste Isolation Pilot Plant. The WIPP Project will assess compliance with the requirements of the United States Environmental Protection Agency. This report forecasts the planned 1992 document, Comparison to 40 CFR, Part 191, Subpart B, for the Waste Isolation Pilot Plant (WIPP). 130 refs., 36 figs., 11 tabs.

  4. Phosphorylation of serine residue modulates cotton Di19-1 and Di19-2 activities for responding to high salinity stress and abscisic acid signaling

    Science.gov (United States)

    Qin, Li-Xia; Nie, Xiao-Ying; Hu, Rong; Li, Gang; Xu, Wen-Liang; Li, Xue-Bao

    2016-01-01

    Di19 (drought-induced protein 19) family is a novel type of Cys2/His2 zinc-finger proteins. In this study, we demonstrated that cotton Di19-1 and Di19-2 (GhDi19-1/-2) proteins could be phosphorylated in vitro by the calcium-dependent protein kinase (CDPK). Mutation of Ser to Ala in N-terminus of GhDi19-1/-2 led to the altered subcellular localization of the two proteins, but the constitutively activated form (Ser was mutated to Asp) of GhDi19-1/-2 still showed the nuclear localization. GhDi19-1/-2 overexpression transgenic Arabidopsis seedlings displayed the hypersensitivity to high salinity and abscisic acid (ABA). However, Ser site-mutated GhDi19-1(S116A) and GhDi19-2(S114A), and Ser and Thr double sites-mutated GhDi19-1(S/T-A/A) and GhDi19-2(S/T-A/A) transgenic Arabidopsis did not show the salt- and ABA-hypersensitive phenotypes. In contrast, overexpression of Thr site-mutated GhDi19-1(T114A) and GhDi19-2(T112A) in Arabidopsis still resulted in salt- and ABA-hypersensitivity phenotypes, like GhDi19-1/-2 transgenic lines. Overexpression of GhDi19-1/-2 and their constitutively activated forms in Atcpk11 background could recover the salt- and ABA-insensitive phenotype of the mutant. Thus, our results demonstrated that Ser phosphorylation (not Thr phosphorylation) is crucial for functionally activating GhDi19-1/-2 in response to salt stress and ABA signaling during early plant development, and GhDi19-1/-2 proteins may be downstream targets of CDPKs in ABA signal pathway. PMID:26829353

  5. Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Volume 4: Uncertainty and sensitivity analyses for 40 CFR 191, Subpart B

    Energy Technology Data Exchange (ETDEWEB)

    1993-08-01

    Before disposing of transuranic radioactive waste in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for a final compliance evaluation. This volume of the 1992 PA contains results of uncertainty and sensitivity analyses with respect to the EPA`s Environmental Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B). Additional information about the 1992 PA is provided in other volumes. Results of the 1992 uncertainty and sensitivity analyses indicate that, conditional on the modeling assumptions, the choice of parameters selected for sampling, and the assigned parameter-value distributions, the most important parameters for which uncertainty has the potential to affect compliance with 40 CFR 191B are: drilling intensity, intrusion borehole permeability, halite and anhydrite permeabilities, radionuclide solubilities and distribution coefficients, fracture spacing in the Culebra Dolomite Member of the Rustler Formation, porosity of the Culebra, and spatial variability of Culebra transmissivity. Performance with respect to 40 CFR 191B is insensitive to uncertainty in other parameters; however, additional data are needed to confirm that reality lies within the assigned distributions.

  6. 麻疹病毒疫苗株沪191和宁波麻疹病毒流行株血清交叉中和试验结果分析%Study on the Cross Neutralizing Antibody between Measles Attenuated Live Vaccine S191 and the Measles Epidemic Strain in Ningbo

    Institute of Scientific and Technical Information of China (English)

    傅燕; 许国章; 董红军; 胡逢蛟; 马瑞; 陆圣诞; 焦素黎

    2013-01-01

    Objective To analyze the protective level of the current measles vaccine (Shanghai 191. S191) and provide evidence for formulating effective strategies of measles prevention. Methods Neutralizing antibody levels to measles vaccine virus strain S191 and wild type virus strain Ningbo2008-06 from different kinds person' s serum were tested by trace neutralization test. Results The geometric mean titer(GMT)to S191 of primarily vaccination serum, acute phase serum of patients immunized with measles vaccine, serum of convalescence patients, serum of pre-emergency vaccination and serum of post-emergency vaccination werel :35.23,:4.16,: 231.74, : 37.81 and 1:61.03 respectively ;while the GMT to Ningbo 2008-06 of the above serum were 1:19.04,: 2.21,: 596.62,: 32.25 and 1:67.54 respectively. The GMT of the serum of primarily vaccine immunization and the serum of acute phase patients against S191 were 1.85 (t=2.537, P<0.05)and 1.88(t=-2.696, P<0.05) times of those against Ningbo 2008-06 respectively. The GMT of the serum of convalescence patients against Ningbo 2008-06 was 2.57 (t=-3.054, P<0.05) times of that against S191.There was no significant difference between the GMT against S191 and Ningbo2008-06 in post-emergency vaccination serum. For infants, their serum' s GMT against S191 and Ningbo2008-06 declined with their growing up. The GMT against Ningbo2008-06 in 6months and 8months old group were 1:2.60 and 1:1.24 respectively. Conclusions The current measles vaccine S191 can neutraliae Ningbo2008-06,but the neutralizing ability decreased. Emergency vaccination can significantly increasebody s neutralization antibody titer to measles. The antibody from mother almost has no protection after 6 months. It is the time to revise current measles immunization strategies.%目的 分析麻疹病毒疫苗株[上海(沪)191,Shanghai191;S191]的免疫保护性,为探讨有效预防控制麻疹的措施提供参考.方法 用微量中和试验测定不同人群血清

  7. 广西壮族自治区恙虫病191例误诊原因分析%Misdiagnosis of Scrub Typhus in Guangxi Zhuang Autonomous Region:A Study of 191 Cases of Scrub Typhus

    Institute of Scientific and Technical Information of China (English)

    曾诚; 张剑锋; 黄英华

    2015-01-01

    目的:对广西壮族自治区近年恙虫病误诊概况进行分析,为进一步提高恙虫病诊治水平提供依据。方法对2009年1月—2013年12月广西医科大学第一附属医院及柳州市人民医院确诊的恙虫病患者临床资料进行整理和数据统计分析。结果两所医院5年间共确诊恙虫病216例,其中误诊191例(88.43%),均为外院误诊。临床表现复杂多样,主要症状有发热、呼吸系统症状、消化系统症状、头痛、皮疹及皮肤焦痂等。主要误诊疾病为不明原因发热(74.87%)、肺炎(9.42%)、上呼吸道感染(6.81%)等。误诊医院为乡镇卫生院67例(35.08%),县级医院64例(33.51%),私人诊所30例(15.71%),市级医院26例(13.61%),省级医院4例(2.09%)。首诊科室主要为内科和急诊科。误诊导致患者并发多器官和(或)系统损害125例(65.45%),其中16例(8.38%)救治无效死亡。结论恙虫病误诊率近年呈上升趋势,误诊医院主要集中在县级及以下医疗机构,应有针对性地加强县、乡级医疗机构医务人员恙虫病诊治相关知识的培训,以降低恙虫病的误诊率。%Objective To investigate the misdiagnosis of scrub typhus in Guangxi Zhuang Autonomous Region in order to provide evidence of improving the diagnosis and reducing multiple organ damages. Methods We analyzed the patients with scrub typhus admitted to the First Affiliated Hospital of Guangxi Medical University and Liuzhou People's Hospital during January 2009 and December 2013. Results There were 216 patients diagnosed with scrub typhus in the region in five years, and 191 ca-ses (88. 43%) were misdiagnosed in other hospitals. The clinical manifestations were complex, including fever, respiratory symptoms, gastrointestinal symptoms, headache, skin rash and scar, etc. They were mainly misdiagnosed as fever of unknown origin (FUO) (74. 87%), pneumonia (9. 42%), upper respiratory tract infection (6. 81%). Sixty

  8. Cloning of a Plasma Membrane Protein Gene TaPM19-1 and Its Response to Abiotic Stresses in Wheat%小麦质膜蛋白基因TaPM19-1的克隆及其对非生物胁迫的响应

    Institute of Scientific and Technical Information of China (English)

    李永春; 张春艳; 张宁; 孟凡荣; 任江萍; 牛洪斌; 王翔; 尹钧

    2012-01-01

    [目的]分析小麦质膜蛋白基因TaPM19-1的特征及其对非生物胁迫的响应,并探讨其在小麦抗逆调控过程中的生物学功能.[方法]利用RACE技术克隆了该基因cDNA全长,采用生物信息学方法分析克隆基因编码蛋白的特性,并通过半定量RT-PCR分析该基因在非生物胁迫条件下的表达特性.[结果]TaPM19-1的cDNA全长1090 bp,无内含子,编码蛋白包含182个氨基酸,分子量为19.02 kD,包含有典型的AWPM19保守域;依据氨基酸序列将来源于不同植物的16个AWPM19类蛋白分为3组,TaPM19-1与2个来源于大麦及1个二穗短柄草的AWPM19类蛋白亲源关系最近,同属于第三组.高级结构分析显示,TaPM19-1可形成4个由α-螺旋组成的跨膜域,N端位于膜内,包含由27个氨基酸组成的信号肽,C端近40个氨基酸位于膜内.表达分析显示,TaPM19-1除在发育后期的种子中有较高水平表达外,其它组织中未检测到表达;在所检测的2个小麦品种根系中,TaPM19-1的表达受ABA诱导,但在叶片中的表达量极低;水分胁迫条件下,该基因在根系和叶片中均呈现较强的诱导表达特性;在高盐和高温胁迫条件下,该基因在洛旱2号小麦中均可诱导表达,而在中国春小麦中未检测到该基因表达;在低温胁迫条件下,未检测到TaPM19-1的表达.[结论]获得了小麦质膜蛋白基因TaPM19-1的cDNA 全长,其编码蛋白可形成典型的跨膜结构特征;该基因受植物激素ABA的诱导,在洛旱2号中也可被干旱、高盐和高温胁迫诱导,但在中国春中对高盐和高温胁迫无响应.推测TaPM19-1在洛旱2号和中国春中存在不同的转录调控机制.%[Objective] The characteristics of a plasma membrane protein gene TaPM19-1 and its response to abiotic stresses in wheat were studied, which will provide an insight into its biological roles involved in the molecular mechanisms of abiotic-sterss response in wheat. [Method] RACE technology was

  9. Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: A model for identifying candidate breast-tumor suppressors

    Directory of Open Access Journals (Sweden)

    Matsui Sei-Ichi

    2008-06-01

    Full Text Available Abstract Background Widely accepted somatic mutation theory of carcinogenesis states that mutations in oncogenes and tumor suppressor genes in genomes of somatic cells is the cause of neoplastic transformation. Identifying frequent mutations in cancer cells suggests the involvement of mutant genes in carcinogenesis. Results To develop an in vitro model for the analysis of genetic alterations associated with breast carcinogenesis, we used random mutagenesis and selection of human non-tumorigenic immortalized breast epithelial cells MCF-10A in tissue-culture conditions that mimic tumor environment. Random mutations were generated in MCF-10A cells by cultivating them in a tissue-culture medium containing the frameshift-inducing agent ICR191. The first selective condition we used to transform MCF1-10A cells was cultivation in a medium containing mutagen at a concentration that allowed cell replication despite p53 protein accumulation induced by mutagen treatment. The second step of selection was either cell cultivation in a medium with reduced growth-factor supply or in a medium that mimics a hypoxia condition or growing in soft agar. Using mutagenesis and selection, we have generated several independently derived cultures with various degrees of transformation. Gene Identification by Nonsense-mediated mRNA decay Inhibition (GINI analysis has identified the ICR191-induced frameshift mutations in the TP53, smoothelin, Ras association (RalGDS/AF-6 domain family 6 (RASSF6 and other genes in the transformed MCF-10A cells. The TP53 gene mutations resulting in the loss of protein expression had been found in all independently transformed MCF-10A cultures, which form large progressively growing tumors with sustained angiogenesis in nude mice. Conclusion Identifying genes containing bi-allelic ICR191-induced frameshift mutations in the transformed MCF-10A cells generated by random mutagenesis and selection indicates putative breast-tumor suppressors. This

  10. Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Volume 1, Third comparison with 40 CFR 191, Subpart B

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-01

    Before disposing of transuranic radioactive wastes in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments of the WIPP for the DOE to provide interim guidance while preparing for final compliance evaluations. This volume contains an overview of WIPP performance assessment and a preliminary comparison with the long-term requirements of the Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B).

  11. Analysis of Chinese Ecommerce Website Profit model--A Case Study in 191 E-commerce Sites%浅析中国电子商务网站盈利模式--以191电子商务网站为例

    Institute of Scientific and Technical Information of China (English)

    成淼

    2014-01-01

    进入21世纪后,电子商务被广泛应用于经济领域中,它已逐渐成为了商家从事商业活动的新模式,而电子商务网站的盈利模式也越来越多样化。主要探讨了191电子商务网站的盈利模式,并对其提出了改善建议。%In the 21st century, E-commerce is widely used in the economic sphere, it has gradually become a new model for businesses engaged in commercial activities, and E-commerce sites are increasingly diversified revenue model. 191 E-commerce sites focus on profit model, and its recommendations for improvement.

  12. Stellar laboratories. VI. New Mo IV - VII oscillator strengths and the molybdenum abundance in the hot white dwarfs G191-B2B and RE0503-289

    CERN Document Server

    Rauch, T; Hoyer, D; Werner, K; Demleitner, M; Kruk, J W

    2015-01-01

    For the spectral analysis of high-resolution and high-signal-to-noise (S/N) spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. To identify molybdenum lines in the ultraviolet (UV) spectra of the DA-type white dwarf G191-B2B and the DO-type white dwarf RE0503-289 and to determine their photospheric Mo abundances, newly calculated Mo IV - VII oscillator strengths are used. We identified twelve Mo V and nine Mo VI lines in the UV spectrum of RE0503-289 and measured a photospheric Mo abundance of 1.2 - 3.0 x 10**-4 (mass fraction, 22500 - 56400 times the solar abundance). In addition, from the As V and Sn IV resonance lines, we measured mass fractions of arsenic (0.5 - 1.3 x 10**-5, about 300 - 1200 times solar) and tin (1.3 - 3.2 x 10**-4, about 14300 35200 times solar). For G191-B2B, upper limits were determined for the abundances of Mo (5.3 x 10*...

  13. Judd-Oflet analysis of spectrum and laser performance of Ho:YAP crystal end-pumped by 1.91-μm Tm:YLF laser

    Institute of Scientific and Technical Information of China (English)

    Yao Bao-Quan; Zheng Liang-Liang; Yang Xiao-Tao; Wang Tian-Heng; Duan Xiao-Ming; Zhao Guang-Jun; Dong Qin

    2009-01-01

    The Ho: YAP crystal is grown by the Czochralski technique. The room-temperature polarized absorption spectra of Ho: YAP crystal was measured on a c-cut sample with 1 at% holmium. According to the obtained Judd-Ofelt intensity parameters Ω2 = 1.42 × 10-20cm2, Ω4 = 2.92 × 10-20cm2, and Ω6 = 1.71 × 10-20cm2, this paper calculated the fluorescence lifetime to be 6 ms for 5I7→5 transition, and the integrated emission cross section to be 2.24× 10-18 cm2. It investigates the room-temperature Ho:YAP laser end-pumped by a 1.91-μm Tm:YLF laser. The maximum output power was 4.1 W when the incident 1.91-μm pump power was 14.4 W. The slope efficiency is 40.8%, corresponding to an optical-to-optical conversion efficiency of 28.4%. The Ho: YAP output wavelength was centred at 2118 ran with full width at half maximum of about 0.8 nm.

  14. Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Vol. 1: Third comparison with 40 CFR 191, Subpart B

    International Nuclear Information System (INIS)

    Before disposing of transuranic radioactive wastes in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments of the WIPP for the DOE to provide interim guidance while preparing for final compliance evaluations. This volume contains an overview of WIPP performance assessment and a preliminary comparison with the long-term requirements of the Environmental Radiation Protection Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B). Detailed information about the technical basis for the preliminary comparison is contained in Volume 2. The reference data base and values for input parameters used in the modeling system are contained in Volume 3. Uncertainty and sensitivity analyses related to 40 CFR 191B are contained in Volume 4. Volume 5 contains uncertainty and sensitivity analyses of gas and brine migration for undisturbed performance. Finally, guidance derived from the entire 1992 performance assessment is presented in Volume 6. Results of the 1992 performance assessment are preliminary, and are not suitable for final comparison with 40 CFR 191, Subpart B. Portions of the modeling system and the data base remain incomplete, and the level of confidence in the performance estimates is not sufficient for a defensible compliance evaluation. Results are, however, suitable for providing guidance to the WIPP Project. All results are conditional on the models and data used, and are presented for preliminary comparison to the Containment Requirements of 40 CFR 191, Subpart B as mean complementary cumulative distribution functions (CCDFs) displaying estimated probabilistic releases of radionuclides to the accessible environment. Results compare three conceptual models for

  15. Searches for neutral Higgs bosons in $e^+ e^-$ collisions from $\\sqrt{s}$ = 191.6 to 201.7 GeV

    CERN Document Server

    Abdallah, J; Adam, W; Adzic, P; Albrecht, T; Alderweireld, T; Alemany-Fernandez, R; Allmendinger, T; Allport, P P; Almehed, S; Amaldi, Ugo; Amapane, N; Amato, S; Anashkin, E; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W D; Arnoud, Y; Ask, S; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Ballestrero, A; Bambade, P; Barbier, R; Bardin, Dimitri Yuri; Barker, G; Baroncelli, A; Battaglia, Marco; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Bellunato, T F; Benekos, N C; Benvenuti, Alberto C; Bérat, C; Berggren, M; Berntzon, L; Bertrand, D; Besançon, M; Besson, N; Bloch, D; Blom, M; Bonesini, M; Boonekamp, M; Booth, P S L; Borisov, G; Botner, O; Bouquet, B; Bowcock, T J V; Boyko, I; Bracko, M; Brenner, R; Brodet, E; Brodzicka, J; Brückman, P; Brunet, J M; Bugge, L; Buschmann, P; Calvi, M; Camporesi, T; Canale, V; Carena, F; Carimalo, C; Castro, N; Cavallo, F R; Chapkin, M M; Charpentier, P; Checchia, P; Chierici, R; Shlyapnikov, P; Chung, S U; Cieslik, K; Collins, P; Contri, R; Cosme, G; Cossutti, F; Costa, M J; Crawley, B; Crennell, D J; Cuevas-Maestro, J; D'Hondt, J; Dalmau, J; Da Silva, T; Da Silva, W; Della Ricca, G; De Angelis, A; de Boer, Wim; De Clercq, C; De Lotto, B; De Maria, N; De Min, A; De Paula, L S; Di Ciaccio, Lucia; Di Simone, A; Doroba, K; Drees, J; Dris, M; Eigen, G; Ekelöf, T J C; Ellert, M; Elsing, M; Espirito-Santo, M C; Fanourakis, G K; Fassouliotis, D; Feindt, Michael; Fernández, J; Ferrer, A; Ferro, F; Flagmeyer, U; Föth, H; Fokitis, E; Fulda-Quenzer, F; Fuster, J A; Gandelman, M; García, C; Gavillet, P; Gazis, E N; Gelé, D; Geralis, T; Gokieli, R; Golob, B; Gómez-Ceballos, G; Gonçalves, P; Graziani, E; Grosdidier, G; Grzelak, K; Guy, J; Haag, C; Hahn, F; Hahn, S; Hallgren, A; Hamacher, K; Hamilton, K; Hansen, J; Haug, S; Hauler, F; Hedberg, V; Hennecke, M; Herr, H; Holmgren, S O; Holt, P J; Houlden, M A; Hultqvist, K; Jackson, J N; Jalocha, P; Jarlskog, C; Jarlskog, G; Jarry, P; Jeans, D; Johansson, E K; Johansson, P D; Jonsson, P; Joram, C; Jungermann, L; Kapusta, F; Katsanevas, S; Katsoufis, E C; Keränen, R; Kernel, G; Kersevan, Borut P; Kiiskinen, A P; King, B T; Kjaer, N J; Kluit, P M; Kokkinias, P; Kourkoumelis, C; Kuznetsov, O; Krumshtein, Z; Kucharczyk, M; Kurowska, J; Laforge, B; Lamsa, J; Leder, Gerhard; Ledroit, F; Leinonen, L; Leitner, R; Lemonne, J; Lenzen, Georg; Lepeltier, V; Lesiak, T; Liebig, W; Liko, D; Lipniacka, A; Lopes, J H; López, J M; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J N; Malek, A; Maltezos, S; Mandl, F; Marco, J; Marco, R; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Martínez-Rivero, C; Masik, J; Mastroyiannopoulos, N; Matorras, F; Matteuzzi, C; Mazzucato, F; Mazzucato, M; McNulty, R; Meroni, C; Meyer, W T; Migliore, E; Mitaroff, Winfried A; Mjörnmark, U; Moa, T; Moch, M; Mönig, K; Monge, R; Montenegro, J; Moraes, D; Moreno, S; Morettini, P; Müller, U; Münich, K; Mulders, M; Mundim, L M; Murray, W; Muryn, B; Myatt, Gerald; Myklebust, T; Nassiakou, M; Navarria, Francesco Luigi; Nawrocki, K; Némécek, S; Nicolaidou, R; Niezurawski, P; Nikolenko, M; Nygren, A; Oblakowska-Mucha, A; Obraztsov, V F; Olshevskii, A G; Onofre, A; Orava, Risto; Österberg, K; Ouraou, A; Oyanguren, A; Paganoni, M; Paiano, S; Palacios, J P; Palka, H; Papadopoulou, T D; Pape, L; Parkes, C; Parodi, F; Parzefall, U; Passeri, A; Passon, O; Peralta, L; Perepelitsa, V F; Perrotta, A; Petrolini, A; Piedra, J; Pieri, L; Pierre, F; Pimenta, M; Piotto, E; Podobnik, T; Poireau, V; Pol, M E; Polok, G; Poropat, P; Pozdnyakov, V; Privitera, P; Pukhaeva, N; Pullia, Antonio; Rames, J; Ramler, L; Read, A; Rebecchi, P; Rehn, J; Reid, D; Reinhardt, R; Renton, P B; Richard, F; Rídky, J; Ripp-Baudot, I; Rodríguez, D; Romero, A; Ronchese, P; Rosenberg, E I; Roudeau, Patrick; Rovelli, T; Ruhlmann-Kleider, V; Ryabtchikov, D; Sadovskii, A; Salmi, L; Salt, J; Savoy-Navarro, Aurore; Schwanda, C; Schwering, B; Schwickerath, U; Segar, A; Sekulin, R L; Siebel, M; Sissakian, A N; Smadja, G; Smirnova, O G; Sokolov, A; Sopczak, André; Sosnowski, R; Spassoff, Tz; Stanitzki, M; Stocchi, A; Strauss, J; Stugu, B; Szczekowski, M; Szeptycka, M; Szumlak, T; Tabarelli de Fatis, T; Taffard, A C; Tegenfeldt, F; Terranova, F; Timmermans, J; Tinti, N; Tkatchev, L G; Tobin, M; Todorovova, S; Tomé, B; Tonazzo, A; Tortosa, P; Travnicek, P; Treille, D; Tristram, G; Trochimczuk, M; Troncon, C; Tyapkin, I A; Tyapkin, P; Tzamarias, S; Ullaland, O; Uvarov, V; Valenti, G; van Dam, P; Van Eldik, J; Van Lysebetten, A; Van Remortel, N; Van Vulpen, I B; Vegni, G; Veloso, F; Venus, W A; Verbeure, F; Verdier, P; Verzi, V; Vilanova, D; Vitale, L; Vrba, V; Wahlen, H; Washbrook, A J; Weiser, C; Wicke, D; Wickens, J H; Wilkinson, G R; Winter, M; Witek, M; Yushchenko, O P; Zalewska-Bak, A; Zalewski, Piotr; Zavrtanik, D; Zimin, N I; Zinchenko, A I; Zoller, P; Zupan, M

    2002-01-01

    Neutral Higgs bosons of the Standard Model ({\\sc SM}) and the Minimal Supersymmetric Standard Model ({\\sc MSSM}) were searched for in the data collected in 1999 by the DELPHI experiment at centre-of-mass energies between 191.6 and 201.7~GeV with a total integrated luminosity of 228 pb$^{-1}$. These analyses, in combination with our results at lower energies, set 95\\% confidence level lower mass bounds on the Standard Model Higgs boson (107.3~GeV/$c^2$) and on the lightest neutral scalar (85.9~GeV/$c^2$) and neutral pseudoscalar (86.5~GeV/$c^2$) Higgs bosons in representative scans of the {\\sc MSSM} parameter space. % excluding $\\tan\\beta$ in the range [0.9-1.6] An extended scan of the {\\sc MSSM} parameter space was also performed to test the robustness of these limits.

  16. Regulatory issues for Waste Isolation Pilot Plant long-term compliance with U.S. Environmental Protection Agency 40 CFR 191B and 268

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, D.R.; Marietta, M.G. [Sandia National Labs., Albuquerque, NM (United States); Higgins, P.J. Jr. [USDOE Albuquerque Field Office, NM (United States). Waste Isolation Pilot Plant Project Integration Office

    1993-10-01

    Before disposing of transuranic radioactive waste at the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with long-term regulations of the United States Environmental Protection Agency (EPA), specifically the Environmental Standards for the Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191), and the Land Disposal Restrictions (40 CFR 268) of the Hazardous and Solid Waste Amendments to the Resource Conservation and Recovery Act (RCRA). Sandia National Laboratories (SNL) is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for final compliance evaluations. This paper provides background information on the regulations, describes the SNL WIPP PA Departments approach to developing a defensible technical basis for consistent compliance evaluations, and summarizes the major observations and conclusions drawn from the 1991 and 1992 PAs.

  17. Regulatory issues for Waste Isolation Pilot Plant long-term compliance with U.S. Environmental Protection Agency 40 CFR 191B and 268

    International Nuclear Information System (INIS)

    Before disposing of transuranic radioactive waste at the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with long-term regulations of the United States Environmental Protection Agency (EPA), specifically the Environmental Standards for the Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191), and the Land Disposal Restrictions (40 CFR 268) of the Hazardous and Solid Waste Amendments to the Resource Conservation and Recovery Act (RCRA). Sandia National Laboratories (SNL) is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for final compliance evaluations. This paper provides background information on the regulations, describes the SNL WIPP PA Departments approach to developing a defensible technical basis for consistent compliance evaluations, and summarizes the major observations and conclusions drawn from the 1991 and 1992 PAs

  18. Flight Test of a 40-Foot Nominal-Diameter Disk-Gap-Band Parachute Deployed at a Mach Number of 1.91

    Science.gov (United States)

    1968-01-01

    Flight Test of a 40-Foot Nominal-Diameter Disk-Gap-Band Parachute Deployed at a Mach Number of 1.91 and a Dynamic Pressure of 11.6 Pounds per Square Foot. A 40-foot (12.2 meter) nominal-diameter disk-gap-band parachute was flight tested as part of the NASA Supersonic Planetary Entry Decelerator Program (SPED-I). The test parachute was ejected by a deployment mortar from an instrumented payload at an altitude of 140,000 feet (42.5 kilometers). The payload was at a Mach number of 1.91 and the dynamic pressure was 11.6 pounds per square foot (555 newtons per square meter) at the time the parachute deployment mortar was fired. The parachute reached suspension line stretch in 0.43 second with a resultant snatch force loading of 1990 pounds (8850 newtons). The maximum parachute opening load of 6500 pounds (28,910 newtons) came 0.61 second later at a total elapsed time from mortar firing of 1.04 seconds. The first full inflation occurred at 1.12 seconds and stable inflation was achieved at approximately 1.60 seconds. The parachute had an average axial-force coefficient of 0.53 during the deceleration period. During the steady-state descent portion of the flight test, the average effective drag coefficient was also 0.53 and pitch-yaw oscillations of the canopy averaged less than 10 degrees in the altitude region above 100,000 feet (30.5 meters). [Entire movie available on DVD from CASI as Doc ID 20070030991. Contact help@sti.nasa.gov

  19. Fast neutron capture cross sections of 169Tm, 191Ir, 193Ir, and 175Lu for 3 less than or equal to E/sub n/ less than or equal to 2000 keV

    International Nuclear Information System (INIS)

    Fast neutron capture cross sections of 169Tm, 191Ir, 193Ir, and 175Lu, and the 6Li(n,α)3H cross sections to which they are normalized are presented in tabular form for neutron energies between 3 and 2000 keV

  20. Chemonuclear studies for identification for new production routes for the therapeutically useful radionuclides 140Nd, 192Ir, 191Pt, 193mPt, und 195mPt

    International Nuclear Information System (INIS)

    New production routes for the therapeutically useful radionuclides 140Nd, 192Ir, 191Pt, 193mPt and 195mPt were investigated. Cross section data were measured using the stacked-foil technique and compared with theoretical calculations. A production method for the platinum nuclides was developed. The 141Pr(p, 2n)140Nd and natCe(3He, xn)140Nd reactions were investigated for production of 140Nd. Cross section data of nuclear reactions leading to the side products 141Nd, 139Nd and 139Ce could also be achieved. The experimental data were compared with theoretical calculations using the code ALICE-IPPE. A comparison of the calculated thick target yields showed that the 141Pr(p, 2n)140Nd reaction gives a higher yield. The 192Os(p, n)192Ir reaction was examined in the context of the production of 192Ir. Cross section data were determined and compared with theoretical calculations using the codes ALICE-IPPE and EMPIRE II. The yield of this reaction was compared with the yield of the reactor production of this nuclide. The reactor production seems to be more suitable because of a higher purity and yield. Cross section data were measured for the 192Os(α, n)195mPt, 192Os(α, 3n)193mPt and 192Os(3He, 4n)191Pt reactions. The activity of 193mPt and 195mPt was determined by X-ray spectroscopy after a chemical separation procedure. The ALICE-IPPE code was found to be inappropriate to reproduce the experimental values. The calculated yields were compared with the yields of other reactions, especially the reactor production of 195mPt. The yield of the 192Os(α, n)195mPt reaction is lower compared to the yield of the reactor production, but offers lower target costs and higher specific activity. A production method for 193mPt and 195mPt was developed. Batch yields of 0.9 MBq 195mPt (specific activity of about 150 GBq/g Pt) and 8.7 MBq 193mPt (ca. 3 TBq/g Pt) could be achieved. The experimental yields were compared with the calculated yields. The agreement between these two data sets

  1. ABCA1基因启动子区-191G/C单核苷酸多态性在冠心病中的意义%Significance of - 191G/C single nucleotide polymorphisms in the promoter region of ATP-binding cassette transporter gene in coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    刘凌; 郭志刚; 王琦光; 刘胜林; 赖文岩; 屠燕

    2005-01-01

    目的研究ABCA1基因启动子区-191G/C单核苷酸多态性(SNP)对血脂的影响及其在冠心病中的意义.方法 用聚合酶链反应-限制性片段长度多态性法(PCR-RFLP)探讨204例冠心病患者和114例正常人的ABCA1基因启动子区-191位点G/C SNP在两组间、冠心病组不同临床表现型之间分布的差异及3种等位基因型与冠心病相关临床指标的关系.结果冠心病组与正常人组比较,3种等位基因型GG、GC、CC分布频率差异具有显著性,CC基因型在冠心病组中的分布频率明显高于正常人组(P<0.05),C等位基因在冠心病组中的分布频率明显高于正常人组(P<0.01).在稳定性心绞痛组(SAP)和急性冠脉综合征组(ACS),3种等位基因型GG、GC、CC分布频率差异也具有显著性,ACS组CC基因型明显高于SAP组(P<0.05),C等位基因在ACS组中分布频率明显高于SAP组(P<0.01).在冠心病组中,3种等位基因型间体重指数、总胆固醇、总甘油三脂、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇等临床指标的比较无显著性差异.结论 ABCA1基因启动子区-191G/C SNP在不影响中国冠心病人群血脂水平的情况下增加冠心病的发生,C等位基因与冠心病的稳定性相关.

  2. Odd and Even Partial Waves of $\\eta\\pi^-$ and $\\eta'\\pi^-$ in 191 GeV/c $\\pi^{-}p$

    CERN Document Server

    Schlüter, T

    2014-01-01

    In the year 2008 COMPASS recorded diffractive events of the signature \\pi^-(191 GeV) p --> X_fast p. We present results of the analysis of the subsystems X = \\eta(')\\pi^-. Besides the known resonances a_2(1320), a_4(2040), we study the properties of the spin-exotic P+ wave, and all other natural-exchange partial waves up to spin J = 6. We find a striking difference between the two final states: whereas the even partial waves J = 2, 4, 6 in the two systems are related by phase-space factors, the odd partial waves are relatively suppressed in the \\eta\\pi^- system. The relative phases between the even waves appear identical whereas the phase between the D and P waves behave quite differently, suggesting different resonant and non-resonant contributions in the two odd-angular-momentum systems. Branching ratios and parameters of the well-known resonances a_2 and a_4 are measured.

  3. Influence of $\\phi$ mesons on negative kaons in Ni+Ni collisions at 1.91A GeV beam energy

    CERN Document Server

    Piasecki, K; Averbeck, R; Andronic, A; Barret, V; Basrak, Z; Bastid, N; Benabderrahmane, M L; Berger, M; Buehler, P; Cargnelli, M; Čaplar, R; Crochet, P; Czerwiakowa, O; Deppner, I; Dupieux, P; Dželalija, M; Fabbietti, L; Fodor, Z; Gasik, P; Gašparić, I; Grishkin, Y; Hartmann, O N; Hildenbrand, K D; Hong, B; Kang, T I; Kecskemeti, J; Kim, Y J; Kirejczyk, M; Kiš, M; Koczon, P; Kotte, R; Lebedev, A; Leifels, Y; Fèvre, A Le; Liu, J L; Lopez, X; Manko, V; Marton, J; Matulewicz, T; Münzer, R; Petrovici, M; Rami, F; Reischl, A; Reisdorf, W; Ryu, M S; Schmidt, P; Schüttauf, A; Seres, Z; Sikora, B; Sim, K S; Simion, V; Siwek-Wilczyńska, K; Smolyankin, V; Suzuki, K; Tymiński, Z; Wagner, P; Weber, I; Widmann, E; Wiśniewski, K; Xiao, Z G; Yushmanov, I; Zhang, Y; Zhilin, A; Zinyuk, V; Zmeskal, J

    2014-01-01

    $\\phi$ and K$^-$ mesons from Ni+Ni collisions at the beam energy of 1.91A GeV have been measured by the FOPI spectrometer, with a trigger selecting central and semi-central events amounting to 51% of the total cross section. The phase space distributions, and the total yield of K$^-$, as well as the kinetic energy distribution and the total yield of $\\phi$ mesons are presented. The $\\phi$\\K$^-$ ratio is found to be $0.44 \\pm 0.07(\\text{stat}) ^{+0.18}_{-0.12} (\\text{syst})$, meaning that about 22% of K$^-$ mesons originate from the decays of $\\phi$ mesons, occurring mostly in vacuum. The inverse slopes of direct kaons are up to about 15 MeV larger than the ones extracted within the one-source model, signalling that a considerable share of gap between the slopes of K$^+$ and K$^-$ could be explained by the contribution of $\\phi$ mesons to negative kaons.

  4. Crystal structure of Sc1.91In1.39Mo15Se19, containing Mo6 and Mo9 clusters

    Directory of Open Access Journals (Sweden)

    Patrick Gougeon

    2015-07-01

    Full Text Available The structure of scandium indium pentadecamolybdenum nonadecaselenide, Sc1.91In1.39Mo15Se19, is isotypic with In2.9Mo15Se19 [Grüttner et al. (1979. Acta Cryst. B35, 285–292]. It is characterized by two cluster units Mo6Sei8Sea6 and Mo9Sei11Sea6 (where i represents inner and a apical atoms that are present in a 1:1 ratio. The cluster units are centered at Wyckoff positions 2b and 2c and have point-group symmetry -3 and -6, respectively. The clusters are interconnected through additional Mo—Se bonds. Sc—Se and In—Se bonds complete the structural set-up. In the title compound, the Sc3+ cations replace the trivalent indium atoms present in In2.9Mo15Se19, and a deficiency is observed at the monovalent indium site. One Mo, one Se and the Sc atom are situated on mirror planes, whereas two other Se atoms and the In atom are situated on threefold rotation axes.

  5. Crystal structure of Sc1.91In1.39Mo15Se19, containing Mo6 and Mo9 clusters.

    Science.gov (United States)

    Gougeon, Patrick; Gall, Philippe; Salloum, Diala

    2015-07-01

    The structure of scandium indium penta-deca-molybdenum nona-deca-selenide, Sc1.91In1.39Mo15Se19, is isotypic with In2.9Mo15Se19 [Grüttner et al. (1979 ▸). Acta Cryst. B35, 285-292]. It is characterized by two cluster units Mo6Se (i) 8Se (a) 6 and Mo9Se (i) 11Se (a) 6 (where i represents inner and a apical atoms) that are present in a 1:1 ratio. The cluster units are centered at Wyckoff positions 2b and 2c and have point-group symmetry -3 and -6, respectively. The clusters are inter-connected through additional Mo-Se bonds. Sc-Se and In-Se bonds complete the structural set-up. In the title compound, the Sc(3+) cations replace the trivalent indium atoms present in In2.9Mo15Se19, and a deficiency is observed at the monovalent indium site. One Mo, one Se and the Sc atom are situated on mirror planes, whereas two other Se atoms and the In atom are situated on threefold rotation axes. PMID:26279861

  6. SOLVENT HOLD TANK SAMPLE RESULTS FOR MCU-13-189, MCU-13-190, AND MCU-13-191: QUARTERLY SAMPLE FROM SEPTEMBER 2013

    Energy Technology Data Exchange (ETDEWEB)

    Fondeur, F.; Taylor-Pashow, K.

    2013-10-31

    Savannah River National Laboratory (SRNL) analyzed solvent samples from Modular Caustic-Side Solvent Extraction Unit (MCU) in support of continuing operations. A quarterly analysis of the solvent is required to maintain solvent composition within specifications. Analytical results of the analyses of Solvent Hold Tank (SHT) samples MCU-13-189, MCU-13-190, and MCU-13-191 received on September 4, 2013 are reported. The results show that the solvent (remaining heel in the SHT tank) at MCU contains excess Isopar� L and a deficit concentration of modifier and trioctylamine when compared to the standard MCU solvent. As with the previous solvent sample results, these analyses indicate that the solvent does not require Isopar� L trimming at this time. Since MCU is switching to NGS, there is no need to add TOA nor modifier. SRNL also analyzed the SHT sample for {{sup 137}Cs content and determined the measured value is within tolerance and the value has returned to levels observed in 2011.

  7. miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression

    Science.gov (United States)

    Hu, Zhonghua; Yu, Danni; Gu, Qin-Hua; Yang, Yanqin; Tu, Kang; Zhu, Jun; Li, Zheng

    2014-02-01

    Activity-dependent modification of dendritic spines, subcellular compartments accommodating postsynaptic specializations in the brain, is an important cellular mechanism for brain development, cognition and synaptic pathology of brain disorders. NMDA receptor-dependent long-term depression (NMDAR-LTD), a prototypic form of synaptic plasticity, is accompanied by prolonged remodelling of spines. The mechanisms underlying long-lasting spine remodelling in NMDAR-LTD, however, are largely unclear. Here we show that LTD induction causes global changes in miRNA transcriptomes affecting many cellular activities. Specifically, we show that expression changes of miR-191 and miR-135 are required for maintenance but not induction of spine restructuring. Moreover, we find that actin depolymerization and AMPA receptor exocytosis are regulated for extended periods of time by miRNAs to support long-lasting spine plasticity. These findings reveal a miRNA-mediated mechanism and a role for AMPA receptor exocytosis in long-lasting spine plasticity, and identify a number of candidate miRNAs involved in LTD.

  8. Odd and even partial waves of ηπ− and η′π− in π−p→η(′)π−p at 191 GeV/c

    NARCIS (Netherlands)

    Adolph, C.; Akhunzyanov, R.; Alexeev, M. G.; Alexeev, G. D.; Amoroso, A.; Andrieux, V.; Anosov, V.; Austregesilo, A.; Badelek, B.; Balestra, F.; Barth, J.; Baum, G.; Beck, R.; Bedfer, Y.; Berlin, A.; Bernhard, J.; Bicker, K.; Bielert, E. R.; Bieling, J.; Birsa, R.; Bisplinghoff, J.; Bodlak, M.; Boer, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bressan, A.; Buechele, M.; Burtin, E.; Capozza, L.; Chiosso, M.; Chung, S. U.; Cicuttin, A.; Crespo, M. L.; Curiel, Q.; Torre, S. Dalla; Dasgupta, S. S.; Dasgupta, S.; Denisov, O. Yu; Donskov, S. V.; Doshita, N.; Duic, V.; Duennweber, W.; Dziewiecki, M.; Efremov, A.; Elia, C.; Eversheim, P. D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Filin, A.; Finger, M.; jr, M. Finger; Fischer, H.; Franco, C.; Hohenesche, N. du Fresne von; Friedrich, J. M.; Frolov, V.; Gautheron, F.; Gavrichtchouk, O. P.; Gerassimov, S.; Geyer, R.; Gnesi, I.; Gobbo, B.; Goertz, S.; Gorzellik, M.; Grabmueller, S.; Grasso, A.; Grube, B.; Grussenmeyer, T.; Guskov, A.; Haas, F.; Harrach, D. von; Hahne, D.; Hashimoto, R.; Heinsius, F. H.; Herrmann, F.; Hinterberger, F.; Hoeppner, Ch; Horikawa, N.; d'Hose, N.; Huber, S.; Ishimoto, S.; Ivanov, A.; Ivanshin, Yu; Iwata, T.; Jahn, R.; Jary, V.; Jasinski, P.; Joerg, P.; Joosten, R.; Kabuss, E.; Ketzer, B.; Khaustov, G. V.; Khokhlov, Yu A.; Kisselev, Yu; Klein, F.; Klimaszewski, K.; Koivuniemi, J. H.; Kolosov, V. N.; Kondo, K.; Koenigsmann, K.; Konorov, I.; Konstantinov, V. F.; Kotzinian, A. M.; Kouznetsov, O.; Kraemer, M.; Kroumchtein, Z. V.; Kuchinski, N.; Kunne, F.; Kurek, K.; Kurjata, R. P.; Lednev, A. A.; Lehmann, A.; Levillain, M.; Levorato, S.; Lichtenstadt, J.; Maggiora, A.; Magnon, A.; Makke, N.; Mallot, G. K.; Marchand, C.; Martin, A.; Marzec, J.; Matousek, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G.; Meyer, W.; Michigami, T.; Mikhailov, Yu V.; Miyachi, Y.; Nagaytsev, A.; Nagel, T.; Nerling, F.; Neubert, S.; Neyret, D.; Nikolaenko, V. I.; Novy, J.; Nowak, W. -D.; Nunes, A. S.; Olshevsky, A. G.; Orlov, I.; Ostrick, M.; Panknin, R.; Panzieri, D.; Parsamyan, B.; Paul, S.; Peshekhonov, D. V.; Platchkov, S.; Pochodzalla, J.; Polyakov, V. A.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Regali, C.; Reicherz, G.; Rocco, E.; Rossiyskaya, N. S.; Ryabchikov, D. I.; Rychter, A.; Samoylenko, V. D.; Sandacz, A.; Sarkar, S.; Savin, I. A.; Sbrizzai, G.; Schiavon, P.; Schill, C.; Schlueter, T.; Schmidt, K.; Schmieden, H.; Schoenning, K.; Schopferer, S.; Schott, M.; Shevchenko, O. Yu; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Sosio, S.; Sozzi, F.; Srnka, A.; Steiger, L.; Stolarski, M.; Sulc, M.; Sulej, R.; Suzuki, H.; Szabelski, A.; Szameitat, T.; Sznajder, P.; Takekawa, S.; Wolbeek, J. ter; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Uhl, S.; Uman, I.; Virius, M.; Wang, L.; Weisrock, T.; Wilfert, M.; Windmolders, R.; Wollny, H.; Zaremba, K.; Zavertyaev, M.; Zemlyanichkina, E.; Ziembicki, M.; Zink, A.

    2015-01-01

    Exclusive production of ηπ− and η′π− has been studied with a 191 GeV/cπ− beam impinging on a hydrogen target at COMPASS (CERN). Partial-wave analyses reveal different odd/even angular momentum (L ) characteristics in the inspected invariant mass range up to 3 GeV/c2. A striking similarity between th

  9. Stellar laboratories II. New Zn IV and Zn V oscillator strengths and their validation in the hot white dwarfs G191-B2B and RE0503-289

    CERN Document Server

    Rauch, T; Quinet, P; Kruk, J W

    2014-01-01

    For the spectral analysis of high-resolution and high-signal-to-noise spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model-atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. In a recent analysis of the ultraviolet (UV) spectrum of the DA-type white dwarf G191-B2B, 21 Zn IV lines were newly identified. Because of the lack of Zn IV data, transition probabilities of the isoelectronic Ge VI were adapted for a first, coarse determination of the photospheric Zn abundance. We performed new calculations of Zn IV and Zn V oscillator strengths to consider their radiative and collisional bound-bound transitions in detail in our NLTE stellar-atmosphere models for the analysis of the Zn IV - V spectrum exhibited in high-resolution and high-S/N UV observations of G191-B2B and RE0503-289. In the UV spectrum of G191-B2B, we identify 31 Zn IV and 16 Zn V lines. Most of these are identified for the first time in an...

  10. Pre-1.91 Ga deformation and metamorphism in the Palaeoproterozoic Vammala Migmatite Belt, southern Finland, and implications for Svecofennian tectonics

    Directory of Open Access Journals (Sweden)

    R. W. Roye Rutland

    2004-01-01

    Full Text Available A metamorphic event in the Vammala Migmatite Belt (VMB at ~1.92 Ga, revealed by SHRIMP U-Pb analyses of both zircon overgrowths and monazite, is interpreted as post-depositional and is correlated with the development of the early high-grade schistosity. Neither this Early Svecofennian deformation and metamorphism, nor the associatedcomplex folding, is present in the overlying Tampere Schist Belt (TSB sequence, consistent with the VMB being part of a pre-1.91 Ga basement complex. The ~1.92 Ga event provides a maximum deposition age for the TSB, confirming earlier age estimates. Earlier stratigraphic correlations between parts of the VMB and TSB, and associated tectonic interpretations, can no longer be sustained. The crustal thickening seen in the VMB, and previously attributed to arc accretion at ~1.89 Ga, is now attributed to accretion of a large Svionian marginal basin during the ‘Early Svecofennian’ orogenicphase at ~1.92 Ga. This is of similar age to the deformation and metamorphism associated with collision in the Lapland-Kola Orogen to the north of the Karelian Province. The well-known post-TSB orogenic phase was also identified in the VMB by a monazite age of 1881±6 Ma. A granitoid intrusion gave an emplacement age of 1888±5 Ma,comparable to the age of granitoid clasts in the upper part of the TSB succession. The detrital zircon data are interpreted to suggest that deposition of the precursor VMB sediments probably took place soon after an earlier pre-depositional metamorphism at ~1.98 Ga, which affected igneous source complexes dated at ~1.99 Ga and ~2.01 Ga. Mafic rocks in the southern part of the VMB, and probably also the Haveri basalts, represent a renewed episode of extensional magmatism, which might correlate with the 1.96–1.95 Ga Jormua and Outokumpu ophiolites. A pre-1.96 Ga older stage basin has an expression in Sweden and complexes of similar age occur in theconcealed Palaeoproterozoic basement south of the Gulf of

  11. Sweet Taste Receptor TAS1R2 Polymorphism (Val191Val) Is Associated with a Higher Carbohydrate Intake and Hypertriglyceridemia among the Population of West Mexico

    Science.gov (United States)

    Ramos-Lopez, Omar; Panduro, Arturo; Martinez-Lopez, Erika; Roman, Sonia

    2016-01-01

    Some high-carbohydrate diets may lead to obesity and multiple metabolic disorders, including hypertriglyceridemia (HTG). This lipid abnormality is considered an important risk factor for cardiovascular disease and type 2 diabetes. The sweet taste receptor TAS1R2 polymorphism (Ile191Val) has been reported to be associated with carbohydrate intake. The aim of this study was to analyze the association of the TAS1R2 gene polymorphism with carbohydrate intake and HTG among the population of West Mexico. In a cross-sectional study, 441 unrelated subjects were analyzed for TAS1R2 genotypes (Ile/Ile, Ile/Val and Val/Val) by an allelic discrimination assay. Biochemical tests and a three-day food record were assessed. The Val/Val genotype carriers had a higher intake of total carbohydrates, fiber and servings of cereals and vegetables than the other genotype carriers. The Val/Val genotype conferred a higher risk for HTG than the Ile/Val and Ile/Ile genotypes (OR = 3.26, 95%CI 1.35–7.86, p = 0.006 and OR = 2.61, 95%CI 1.12–6.07, p = 0.02, respectively). Furthermore, the Val/Val genotype was associated with approximately 30% higher triglycerides compared with Ile/Val and Ile/Ile genotypes (β = 44.09, 95%CI 9.94–78.25, p = 0.01 and β = 45.7, 95%CI 10.85–80.54, p = 0.01, respectively). In conclusion, the Val/Val genotype of TAS1R2 was associated with a higher carbohydrate intake and HTG. PMID:26907331

  12. One-Pot Synthesis of (NiFe2O4)x-(SrFe12O19)1-x Nanocomposites and Their Microwave Absorption Properties.

    Science.gov (United States)

    Hazra, Subhenjit; Ghosh, Barun Kumar; Patra, Manoj Kumar; Jani, Raj Kumar; Vadera, Sampat Raj; Ghosh, Narendra Nath

    2015-09-01

    In this paper, we report a simple but novel aqueous solution based 'one-pot' method for preparation of (NiFe2O4)x-(SrFe12O19)1-x nanocomposites consist of hard ferrite-soft ferrite phases. A physical mixing method has also been employed to prepare nanocomposites having same compositions. The effects of synthetic methodologies on the microstructures of the nanocomposites as well as their magnetic and microwave absorption properties have been evaluated. Crystal structures and microstructures of these composites have been investigated by using X-ray diffraction, transmission electron microscope and scanning electron microscope. In the nanocomposites, prepared by both methods, presence of nanocrystalline NiFe2O4 and SrFe12O19 phases was detected. However, nanocomposites, prepared by one-pot method, possessed better homogeneous distribution of hard and soft ferrite phases than the nanocomposites, prepared by physical mixing method. Nanocomposites, prepared by one-pot method, demonstrated significant spring exchange coupling interaction between hard and soft ferrite phases and exhibited magnetically single phase behaviour. The spring exchange coupling interaction enhanced the magnetic properties (high saturation magnetization and coercivity) and microwave absorption properties of the nanocomposites, prepared by one-pot method, in comparison with the nanocomposites prepared by physical mixing method as well as pure NiFe2O4 and SrFe12O19 nanoparticles. Minimum reflection loss of the composite was ~ -17 dB (i.e., 98% absorption) at 8.2 GHz for an absorber thickness of 3.2 mm. PMID:26716212

  13. Stellar Laboratories II. New Zn Iv and Zn v Oscillator Strengths and Their Validation in the Hot White Dwarfs G191-B2B and RE0503-289

    Science.gov (United States)

    Rauch, T.; Werner, K.; Quinet, P.; Kruk, J. W.

    2014-01-01

    Context. For the spectral analysis of high-resolution and high-signal-to-noise (SN) spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. In a recent analysis of the ultraviolet (UV) spectrum of the DA-type white dwarf G191B2B,21 Zn iv lines were newly identified. Because of the lack of Zn iv data, transition probabilities of the isoelectronic Ge vi were adapted for a first, coarse determination of the photospheric Zn abundance.Aims. Reliable Zn iv and Zn v oscillator strengths are used to improve the Zn abundance determination and to identify more Zn lines in the spectra of G191B2B and the DO-type white dwarf RE 0503289. Methods. We performed new calculations of Zn iv and Zn v oscillator strengths to consider their radiative and collisional bound-bound transitions in detail in our NLTE stellar-atmosphere models for the analysis of the Zn iv v spectrum exhibited in high-resolution and high-SN UV observations of G191B2B and RE 0503289. Results. In the UV spectrum of G191B2B, we identify 31 Zn iv and 16 Zn v lines. Most of these are identified for the first time in any star. We can reproduce well almost all of them at log Zn 5.52 0.2 (mass fraction, about 1.7 times solar). In particular, the Zn iv Zn v ionization equilibrium, which is a very sensitive Teff indicator, is well reproduced with the previously determined Teff 60 000 2000 K and log g 7.60 0.05. In the spectrum of RE 0503289, we identified 128 Zn v lines for the first time and determined log Zn 3.57 0.2 (155 times solar). Conclusions. Reliable measurements and calculations of atomic data are a pre-requisite for stellar-atmosphere modeling. Observed Zn iv and Zn v line profiles in two white dwarf (G191B2B and RE 0503289) ultraviolet spectra were well reproduced with our newly calculated oscillator strengths. This allowed us to determine the

  14. Process for producing astatine-211 for radiopharmaceutical use

    International Nuclear Information System (INIS)

    A one-step chemical manipulation is described in combination with a distillation and collection process for producing At-211 comprising; a. providing a target of irradiated Bismuth coated to a predetermined thickness of a backing member, b. providing a vapor-producing still operably connected with a condenser that has a water cooled condensate collector formed of a dry silica gel mesh maintained at a temperature above the freezing point of water, and providing an effluent gas filter that is operably connected to receive effluent gas from the condenser, c. heating the target in the still at a temperature in the range of about 6300-6800C for a time period in the range of 50 to 80 minutes, to evole At-211 vapor from the target, c. providing a dry carrier gas having an oxygen concentration that is sufficient to form Bi/sub 2/O/sub 3/ thereby to essentially preclude vaporization of Bi metal, passing the carrier gas through the still to carry the At-211 vapor to the condenser, and to carry effluent from the condenser to the effluent gas filter, e. eluting At-211 from the condensate collector of the condenser with a controlled volume of eluent containing predetermined solvents that are compatible with a given desired radiopharmaceutical procedure, and f. collecting the At-211 in the controlled volume of eluent for use in the given radiopharmaceutical procedure

  15. Chemonuclear studies for identification for new production routes for the therapeutically useful radionuclides {sup 140}Nd, {sup 192}Ir, {sup 191}Pt, {sup 193m}Pt, und {sup 195m}Pt; Kernchemische Studien zur Entwicklung neuerer Produktionsverfahren fuer die therapierelevanten Radionuklide {sup 140}Nd, {sup 192}Ir, {sup 191}Pt, {sup 193m}Pt, und {sup 195m}Pt

    Energy Technology Data Exchange (ETDEWEB)

    Hilgers, K.

    2005-12-15

    New production routes for the therapeutically useful radionuclides {sup 140}Nd, {sup 192}Ir, {sup 191}Pt, {sup 193m}Pt and {sup 195m}Pt were investigated. Cross section data were measured using the stacked-foil technique and compared with theoretical calculations. A production method for the platinum nuclides was developed. The {sup 141}Pr(p, 2n){sup 140}Nd and {sup nat}Ce({sup 3}He, xn){sup 140}Nd reactions were investigated for production of {sup 140}Nd. Cross section data of nuclear reactions leading to the side products {sup 141}Nd, {sup 139}Nd and {sup 139}Ce could also be achieved. The experimental data were compared with theoretical calculations using the code ALICE-IPPE. A comparison of the calculated thick target yields showed that the {sup 141}Pr(p, 2n){sup 140}Nd reaction gives a higher yield. The {sup 192}Os(p, n){sup 192}Ir reaction was examined in the context of the production of {sup 192}Ir. Cross section data were determined and compared with theoretical calculations using the codes ALICE-IPPE and EMPIRE II. The yield of this reaction was compared with the yield of the reactor production of this nuclide. The reactor production seems to be more suitable because of a higher purity and yield. Cross section data were measured for the {sup 192}Os({alpha}, n){sup 195m}Pt, {sup 192}Os({alpha}, 3n){sup 193m}Pt and {sup 192}Os({sup 3}He, 4n){sup 191}Pt reactions. The activity of {sup 193m}Pt and {sup 195m}Pt was determined by X-ray spectroscopy after a chemical separation procedure. The ALICE-IPPE code was found to be inappropriate to reproduce the experimental values. The calculated yields were compared with the yields of other reactions, especially the reactor production of {sup 195m}Pt. The yield of the {sup 192}Os({alpha}, n){sup 195m}Pt reaction is lower compared to the yield of the reactor production, but offers lower target costs and higher specific activity. A production method for {sup 193m}Pt and {sup 195m}Pt was developed. Batch yields of 0.9 MBq

  16. Stellar Laboratories: 3. New Ba 5, Ba 6, and Ba 7 Oscillator Strengths and the Barium Abundance in the Hot White Dwarfs G191-B2B and RE 0503-289

    Science.gov (United States)

    Rauch, T.; Werner, K.; Quinet, P.; Kruk, Jeffrey Walter

    2014-01-01

    Context. For the spectral analysis of high-resolution and high-signal-to-noise (S/N) spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. Aims. Reliable Ba 5-7 oscillator strengths are used to identify Ba lines in the spectra of the DA-type white dwarf G191-B2B and the DO-type white dwarf RE 0503-289 and to determine their photospheric Ba abundances. Methods. We newly calculated Ba v-vii oscillator strengths to consider their radiative and collisional bound-bound transitions in detail in our NLTE stellar-atmosphere models for the analysis of Ba lines exhibited in high-resolution and high-S/N UV observations of G191-B2B and RE 0503-289. Results. For the first time, we identified highly ionized Ba in the spectra of hot white dwarfs. We detected Ba vi and Ba vii lines in the Far Ultraviolet Spectroscopic Explorer (FUSE) spectrum of RE 0503-289. The Ba vi/Ba vii ionization equilibrium is well reproduced with the previously determined effective temperature of 70 000 K and surface gravity of log g=7.5. The Ba abundance is 3.5 +/- 0.5 × 10(exp-4) (mass fraction, about 23 000 times the solar value). In the FUSE spectrum of G191-B2B, we identified the strongest Ba vii line (at 993.41 Å) only, and determined a Ba abundance of 4.0 +/- 0.5 × 10(exp-6) (about 265 times solar). Conclusions. Reliable measurements and calculations of atomic data are a pre-requisite for stellar-atmosphere modeling. Observed Ba vi-vii line profiles in two white dwarfs' (G191-B2B and RE 0503-289) far-ultraviolet spectra were well reproduced with our newly calculated oscillator strengths. This allowed to determine the photospheric Ba abundance of these two stars precisely.

  17. A Continuous-Wave Ho:YAlO3 Laser with Output 8.5 W Pumped by a 1.91 μm Laser at Room Temperature

    Institute of Scientific and Technical Information of China (English)

    YAO Bao-Quan; YANG Xiao-Tao; DUAN Xiao-Ming; WANG Tian-Heng; JU You-Lun; WANG Yue-Zhu

    2009-01-01

    @@ A cw high efficient Ho:YAlO3 laser pumped by 1.91 μm diode-pumped Tm:YLF laser at room temperature is realized. The maximum output power reaches 8.5 W when the incident pump power is 15.6 W. The slope efficiency is 63.7%, and the Tm:YLF to Ho:YAP optical conversion efficiency is 54.5%. The laser wavelength is 2118.3nm when the transmission of output coupler is 30%. The beam quality factor is M2~1.39 measured by the traveling knife-edge method.

  18. Stellar laboratories III. New Ba V, Ba VI, and Ba VII oscillator strengths and the barium abundance in the hot white dwarfs G191-B2B and RE0503-289

    CERN Document Server

    Rauch, T; Quinet, P; Kruk, J W

    2014-01-01

    For the spectral analysis of high-resolution and high-signal-to-noise (S/N) spectra of hot stars, state-of-the-art non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These are strongly dependent on the reliability of the atomic data that is used for their calculation. Reliable Ba V - VII oscillator strengths are used to identify Ba lines in the spectra of the DA-type white dwarf G191-B2B and the DO-type white dwarf RE0503-289 and to determine their photospheric Ba abundances. We newly calculated Ba V - VII oscillator strengths to consider their radiative and collisional bound-bound transitions in detail in our NLTE stellar-atmosphere models for the analysis of Ba lines exhibited in high-resolution and high-S/N UV observations of G191-B2B and RE0503-289. For the first time, we identified highly ionized Ba in the spectra of hot white dwarfs. We detected Ba VI and Ba VII lines in the Far Ultraviolet Spectroscopic Explorer (FUSE) spectrum of RE0503-289. The Ba VI / Ba VII ionization equil...

  19. Stellar laboratories IV. New Ga IV, Ga V, and Ga VI oscillator strengths and the gallium abundance in the hot white dwarfs G191-B2B and RE0503-289

    CERN Document Server

    Rauch, T; Quinet, P; Kruk, J W

    2015-01-01

    For the spectral analysis of high-resolution and high-signal-to-noise (S/N) spectra of hot stars, advanced non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory. These atmospheres are strongly dependent on the reliability of the atomic data that are used to calculate them. Reliable Ga IV - VI oscillator strengths are used to identify Ga lines in the spectra of the DA-type white dwarf G191-B2B and the DO-type white dwarf RE0503-289 and to determine their photospheric Ga abundances. We newly calculated Ga IV - VI oscillator strengths to consider their radiative and collisional bound-bound transitions in detail in our NLTE stellar-atmosphere models for analyzing of Ga lines exhibited in high-resolution and high-S/N UV observations of G191-B2B and RE0503-289. We unambiguously detected 20 isolated and 6 blended (with lines of other species) Ga V lines in the Far Ultraviolet Spectroscopic Explorer (FUSE) spectrum of RE0503-289. The identification of Ga IV and Ga VI lines is uncertain because th...

  20. Basic residues in the 74-83 and 191-198 segments of protein kinase CK2 catalytic subunit are implicated in negative but not in positive regulation by the beta-subunit

    DEFF Research Database (Denmark)

    Sarno, S; Vaglio, P; Marin, O; Meggio, F; Issinger, O G; Pinna, L A

    1997-01-01

    Protein kinase CK2 is a ubiquitous pleiotropic serine/threonine protein kinase whose holoenzyme is comprised of two catalytic (alpha and/or alpha') and two non-catalytic, beta-subunits. The beta-subunit possesses antagonist functions that can be physically dissected by generating synthetic...... fragments encompassing its N-terminal and C-terminal domains. Here we show that by mutating basic residues in the 74-77 and in the 191-198 regions of the alpha-subunit, the negative regulation by the beta-subunit and by its N-terminal synthetic fragment CK2beta-(1-77), which is observable using calmodulin...... as a substrate for phosphorylation, is drastically reduced. In contrast, the positive regulation by a C-terminal, CK2beta-(155-215)-peptide is unaffected or even increased. Moreover, the basal activity of alpha mutants K74-77A, K79R80K83A, and R191R195K198A toward specific peptide substrates is...

  1. High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191.

    Science.gov (United States)

    Prasad, Joni M; Young, Patricia A; Strickland, Dudley K

    2016-08-26

    The LDL receptor-related protein 1 (LRP1) is a large endocytic receptor that binds and mediates the endocytosis of numerous structurally diverse ligands. Currently, the basis for ligand recognition by LRP1 is not well understood. LRP1 requires a molecular chaperone, termed the receptor-associated protein (RAP), to escort the newly synthesized receptor from the endoplasmic reticulum to the Golgi. RAP is a three-domain protein that contains the following two high affinity binding sites for LRP1: one is located within domains 1 and 2, and one is located in its third domain. Studies on the interaction of the RAP third domain with LRP1 reveal critical contributions by lysine 256 and lysine 270 for this interaction. From these studies, a model for ligand recognition by this class of receptors has been proposed. Here, we employed surface plasmon resonance to investigate the binding of RAP D1D2 to LRP1. Our results reveal that the high affinity of D1D2 for LRP1 results from avidity effects mediated by the simultaneous interactions of lysine 60 in D1 and lysine 191 in D2 with sites on LRP1 to form a bivalent D1D2-LRP1 complex. When lysine 60 and 191 are both mutated to alanine, the binding of D1D2 to LRP1 is ablated. Our data also reveal that D1D2 is able to bind to a second distinct site on LRP1 to form a monovalent complex. The studies confirm the canonical model for ligand recognition by this class of receptors, which is initiated by pairs of lysine residues that dock into acidic pockets on the receptor. PMID:27402839

  2. The Virtual Observatory Service TheoSSA: Establishing a Database of Synthetic Stellar Flux Standards I. NLTE Spectral Analysis of the DA-Type White Dwarf G191-B2B *,**,***,****

    Science.gov (United States)

    Rauch, T.; Werner, K.; Bohlin, R.; Kruk, J. W.

    2013-01-01

    Hydrogen-rich, DA-type white dwarfs are particularly suited as primary standard stars for flux calibration. State-of-the-art NLTE models consider opacities of species up to trans-iron elements and provide reliable synthetic stellar-atmosphere spectra to compare with observations. Aims. We will establish a database of theoretical spectra of stellar flux standards that are easily accessible via a web interface. Methods. In the framework of the Virtual Observatory, the German Astrophysical Virtual Observatory developed the registered service TheoSSA. It provides easy access to stellar spectral energy distributions (SEDs) and is intended to ingest SEDs calculated by any model-atmosphere code. In case of the DA white dwarf G191-B2B, we demonstrate that the model reproduces not only its overall continuum shape but also the numerous metal lines exhibited in its ultraviolet spectrum. Results. TheoSSA is in operation and contains presently a variety of SEDs for DA-type white dwarfs. It will be extended in the near future and can host SEDs of all primary and secondary flux standards. The spectral analysis of G191-B2B has shown that our hydrostatic models reproduce the observations best at Teff =60 000 +/- 2000K and log g=7.60 +/- 0.05.We newly identified Fe vi, Ni vi, and Zn iv lines. For the first time, we determined the photospheric zinc abundance with a logarithmic mass fraction of -4.89 (7.5 × solar). The abundances of He (upper limit), C, N, O, Al, Si, O, P, S, Fe, Ni, Ge, and Sn were precisely determined. Upper abundance limits of about 10% solar were derived for Ti, Cr, Mn, and Co. Conclusions. The TheoSSA database of theoretical SEDs of stellar flux standards guarantees that the flux calibration of all astronomical data and cross-calibration between different instruments can be based on the same models and SEDs calculated with different model-atmosphere codes and are easy to compare.

  3. Networks of icosahedra in the sodium-zinc-stannides Na16Zn13.54Sn13.46(5), Na22Zn20Sn19(1), and Na34Zn66Sn38(1)

    International Nuclear Information System (INIS)

    The three new ternary phases Na16Zn13.54Sn13.46(5) (I), Na22Zn20Sn19(1) (II), and Na34Zn66Sn38(1) (III) were obtained by direct fusion of the pure elements and characterized by single crystal X-ray diffraction experiments: I, Ibam, Z=8, a=27.401(1), b=16.100(1), c=18.431(1) A, R1/wR2 (all data)=0.051/0.088; II, Pnma, Z=4, a=16.403(1), b=15.598(1), c=22.655(6) A, R1/wR2 (all data)=0.038/0.071; III, R3-bar m, Z=3, a=16.956(1), c=36.861(1) A, R1/wR2 (all data)=0.045/0.092. The structures consist of complex 3D cluster networks made of Zn and Sn atoms with the common motif of Kagome nets of icosahedra. Additionally to the new heteroatomic {Zn12-xSnx} icosahedra that are omnipresent, triangular units, cages, and pairs of triply fused icosahedra fill the cavities of the Kagome nets in compounds I, II, and III, respectively. Whereas I crystallizes in a new structure type, II and III have structural analogs in trielide chemistry. All three compounds closely approach the electron numbers expected for valence compounds according to the extended 8-N rule. The concept of achieving an isovalent situation to triel elements by combination of electron poorer and richer elements and the readily mixing of Zn and Sn allow the formation of icosahedral and triangular clusters without the participation of a group 13 element. - Graphical abstract: Three new compounds Na16Zn13.54Sn13.46(5) (I), Na22Zn20Sn19(1) (II), and Na34Zn66Sn38(1) (III) were obtained from the elements and were characterized by single-crystal X-ray diffraction. Their structures have in common Kagome layers of {Zn12-xSnx} icosahedra. Additional building units, such as triangles, 15-atom spacer, and triply fused icosahedra fill the structures of I, II, and III, respectively. The structures and the electron requirements are discussed.

  4. The virtual observatory service TheoSSA: Establishing a database of synthetic stellar flux standards. I. NLTE spectral analysis of the DA-type white dwarf G 191-B2B

    CERN Document Server

    Rauch, T; Kruk, J W; Werner, K

    2013-01-01

    H-rich, DA-type white dwarfs are particularly suited as primary standard stars for flux calibration. State-of-the-art NLTE models consider opacities of species up to trans-iron elements and provide reliable synthetic stellar-atmosphere spectra to compare with observation. We establish a database of theoretical spectra of stellar flux standards that are easily accessible via a web interface. In the framework of the Virtual Observatory, the German Astrophysical Virtual Observatory developed the registered service TheoSSA. It provides easy access to stellar spectral energy distributions (SEDs) and is intended to ingest SEDs calculated by any model-atmosphere code. In case of the DA white dwarf G 191-B2B, we demonstrate that the model reproduces not only its overall continuum shape but also the numerous metal lines exhibited in its ultraviolet spectrum. TheoSSA is in operation and contains presently a variety of SEDs for DA white dwarfs. It will be extended in the near future and can host SEDs of all primary and ...

  5. Odd and even partial waves of ηπ− and η′π− in π−p→η(′π−p at 191 GeV/c

    Directory of Open Access Journals (Sweden)

    C. Adolph

    2015-01-01

    Full Text Available Exclusive production of ηπ− and η′π− has been studied with a 191 GeV/c π− beam impinging on a hydrogen target at COMPASS (CERN. Partial-wave analyses reveal different odd/even angular momentum (L characteristics in the inspected invariant mass range up to 3 GeV/c2. A striking similarity between the two systems is observed for the L=2,4,6 intensities (scaled by kinematical factors and the relative phases. The known resonances a2(1320 and a4(2040 are in line with this similarity. In contrast, a strong enhancement of η′π− over ηπ− is found for the L=1,3,5 waves, which carry non-qq¯ quantum numbers. The L=1 intensity peaks at 1.7 GeV/c2 in η′π− and at 1.4 GeV/c2 in ηπ−, the corresponding phase motions with respect to L=2 are different.

  6. Odd and Even Partial Waves of $\\eta\\pi^-$ and $\\eta'\\pi^-$ in $\\pi^-p\\to\\eta^{(\\prime)}\\pi^-p$ at $191\\,\\textrm{GeV}/c$

    CERN Document Server

    Adolph, C.; Alexeev, M.G.; Alexeev, G.D.; Amoroso, A.; Andrieux, V.; Anosov, V.; Austregesilo, A.; Badelek, B.; Balestra, F.; Barth, J.; Baum, G.; Beck, R.; Bedfer, Y.; Berlin, A.; Bernhard, J.; Bicker, K.; Bielert, E.R.; Bieling, J.; Birsa, R.; Bisplinghoff, J.; Bodlak, M.; Boer, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bressan, A.; Buchele, M.; Burtin, E.; Capozza, L.; Chiosso, M.; Chung, S.U.; Cicuttin, A.; Crespo, M.L.; Curiel, Q.; Dalla Torre, S.; Dasgupta, S.S.; Dasgupta, S.; Denisov, O.Yu.; Donskov, S.V.; Doshita, N.; Duic, V.; Dunnweber, W.; Dziewiecki, M.; Efremov, A.; Elia, C.; Eversheim, P.D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Finger, M.; M. Finger jr; Fischer, H.; Franco, C.; von Hohenesche, N. du Fresne; Friedrich, J.M.; Frolov, V.; Gautheron, F.; Gavrichtchouk, O.P.; Gerassimov, S.; Geyer, R.; Gnesi, I.; Gobbo, B.; Goertz, S.; Gorzellik, M.; Grabmuller, S.; Grasso, A.; Grube, B.; Grussenmeyer, T.; Guskov, A.; Haas, F.; von Harrach, D.; Hahne, D.; Hashimoto, R.; Heinsius, F.H.; Herrmann, F.; Hinterberger, F.; Hoppner, Ch.; Horikawa, N.; d'Hose, N.; Huber, S.; Ishimoto, S.; Ivanov, A.; Ivanshin, Yu.; Iwata, T.; Jahn, R.; Jary, V.; Jasinski, P.; Jorg, P.; Joosten, R.; Kabuss, E.; Ketzer, B.; Khaustov, G.V.; Khokhlov, Yu. A.; Kisselev, Yu.; Klein, F.; Klimaszewski, K.; Koivuniemi, J.H.; Kolosov, V.N.; Kondo, K.; Konigsmann, K.; Konorov, I.; Konstantinov, V.F.; Kotzinian, A.M.; Kouznetsov, O.; Kramer, M.; Kroumchtein, Z.V.; Kuchinski, N.; Kunne, F.; Kurek, K.; Kurjata, R.P.; Lednev, A.A.; Lehmann, A.; Levillain, M.; Levorato, S.; Lichtenstadt, J.; Maggiora, A.; Magnon, A.; Makke, N.; Mallot, G.K.; Marchand, C.; Martin, A.; Marzec, J.; Matousek, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G.; Meyer, W.; Michigami, T.; Mikhailov, Yu. V.; Miyachi, Y.; Nagaytsev, A.; Nagel, T.; Nerling, F.; Neubert, S.; Neyret, D.; Novy, J.; Nowak, W.D.; Nunes, A.S.; Olshevsky, A.G.; Orlov, I.; Ostrick, M.; Panknin, R.; Panzieri, D.; Parsamyan, B.; Paul, S.; Peshekhonov, D.V.; Platchkov, S.; Pochodzalla, J.; Polyakov, V.A.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Regali, C.; Reicherz, G.; Rocco, E.; Rossiyskaya, N.S.; Ryabchikov, D.I.; Rychter, A.; Samoylenko, V.D.; Sandacz, A.; Sarkar, S.; Savin, I.A.; Sbrizzai, G.; Schiavon, P.; Schill, C.; Schluter, T.; Schmidt, K.; Schmieden, H.; Schonning, K.; Schopferer, S.; Schott, M.; Shevchenko, O.Yu.; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Sosio, S.; Sozzi, F.; Srnka, A.; Steiger, L.; Stolarski, M.; Sulc, M.; Sulej, R.; Suzuki, H.; Szabelski, A.; Szameitat, T.; Sznajder, P.; Takekawa, S.; Wolbeek, J. ter; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Uhl, S.; Uman, I.; Virius, M.; Wang, L.; Weisrock, T.; Wilfert, M.; Windmolders, R.; Wollny, H.; Zaremba, K.; Zavertyaev, M.; Zemlyanichkina, E.; Ziembicki, M.; Zink, A.

    2015-01-01

    Exclusive production of $\\eta\\pi^-$ and $\\eta'\\pi^-$ has been studied with a $191\\,\\textrm{GeV}/c$ $\\pi^-$ beam impinging on a hydrogen target at COMPASS (CERN). Partial-wave analyses reveal different odd/even angular momentum ($L$) characteristics in the inspected invariant mass range up to $3\\,\\textrm{GeV}/c^2$. A striking similarity between the two systems is observed for the $L=2,4,6$ intensities (scaled by kinematical factors) and the relative phases. The known resonances $a_2(1320)$ and $a_4(2040)$ are in line with this similarity. In contrast, a strong enhancement of $\\eta'\\pi^-$ over $\\eta\\pi^-$ is found for the $L=1,3,5$ waves, which carry non-$q\\bar q$ quantum numbers. The $L=1$ intensity peaks at $1.7\\,\\textrm{GeV}/c^2$ in $\\eta'\\pi^-$ and at $1.4\\,\\textrm{GeV}/c^2$ in $\\eta\\pi^-$, the corresponding phase motions with respect to $L=2$ are different.

  7. Odd and even partial waves of ηπ- and η‧π- in π- p →η (‧)π- p at 191 GeV / c

    Science.gov (United States)

    Adolph, C.; Akhunzyanov, R.; Alexeev, M. G.; Alexeev, G. D.; Amoroso, A.; Andrieux, V.; Anosov, V.; Austregesilo, A.; Badełek, B.; Balestra, F.; Barth, J.; Baum, G.; Beck, R.; Bedfer, Y.; Berlin, A.; Bernhard, J.; Bicker, K.; Bielert, E. R.; Bieling, J.; Birsa, R.; Bisplinghoff, J.; Bodlak, M.; Boer, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bressan, A.; Büchele, M.; Burtin, E.; Capozza, L.; Chiosso, M.; Chung, S. U.; Cicuttin, A.; Crespo, M. L.; Curiel, Q.; Dalla Torre, S.; Dasgupta, S. S.; Dasgupta, S.; Denisov, O. Yu.; Donskov, S. V.; Doshita, N.; Duic, V.; Dünnweber, W.; Dziewiecki, M.; Efremov, A.; Elia, C.; Eversheim, P. D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Finger, M.; Finger, M.; Fischer, H.; Franco, C.; du Fresne von Hohenesche, N.; Friedrich, J. M.; Frolov, V.; Gautheron, F.; Gavrichtchouk, O. P.; Gerassimov, S.; Geyer, R.; Gnesi, I.; Gobbo, B.; Goertz, S.; Gorzellik, M.; Grabmüller, S.; Grasso, A.; Grube, B.; Grussenmeyer, T.; Guskov, A.; Haas, F.; von Harrach, D.; Hahne, D.; Hashimoto, R.; Heinsius, F. H.; Herrmann, F.; Hinterberger, F.; Höppner, Ch.; Horikawa, N.; d'Hose, N.; Huber, S.; Ishimoto, S.; Ivanov, A.; Ivanshin, Yu.; Iwata, T.; Jahn, R.; Jary, V.; Jasinski, P.; Jörg, P.; Joosten, R.; Kabuß, E.; Ketzer, B.; Khaustov, G. V.; Khokhlov, Yu. A.; Kisselev, Yu.; Klein, F.; Klimaszewski, K.; Koivuniemi, J. H.; Kolosov, V. N.; Kondo, K.; Königsmann, K.; Konorov, I.; Konstantinov, V. F.; Kotzinian, A. M.; Kouznetsov, O.; Krämer, M.; Kroumchtein, Z. V.; Kuchinski, N.; Kunne, F.; Kurek, K.; Kurjata, R. P.; Lednev, A. A.; Lehmann, A.; Levillain, M.; Levorato, S.; Lichtenstadt, J.; Maggiora, A.; Magnon, A.; Makke, N.; Mallot, G. K.; Marchand, C.; Martin, A.; Marzec, J.; Matousek, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G.; Meyer, W.; Michigami, T.; Mikhailov, Yu. V.; Miyachi, Y.; Nagaytsev, A.; Nagel, T.; Nerling, F.; Neubert, S.; Neyret, D.; Novy, J.; Nowak, W.-D.; Nunes, A. S.; Olshevsky, A. G.; Orlov, I.; Ostrick, M.; Panknin, R.; Panzieri, D.; Parsamyan, B.; Paul, S.; Peshekhonov, D. V.; Platchkov, S.; Pochodzalla, J.; Polyakov, V. A.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Regali, C.; Reicherz, G.; Rocco, E.; Rossiyskaya, N. S.; Ryabchikov, D. I.; Rychter, A.; Samoylenko, V. D.; Sandacz, A.; Sarkar, S.; Savin, I. A.; Sbrizzai, G.; Schiavon, P.; Schill, C.; Schlüter, T.; Schmidt, K.; Schmieden, H.; Schönning, K.; Schopferer, S.; Schott, M.; Shevchenko, O. Yu.; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Sosio, S.; Sozzi, F.; Srnka, A.; Steiger, L.; Stolarski, M.; Sulc, M.; Sulej, R.; Suzuki, H.; Szabelski, A.; Szameitat, T.; Sznajder, P.; Takekawa, S.; ter Wolbeek, J.; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Uhl, S.; Uman, I.; Virius, M.; Wang, L.; Weisrock, T.; Wilfert, M.; Windmolders, R.; Wollny, H.; Zaremba, K.; Zavertyaev, M.; Zemlyanichkina, E.; Ziembicki, M.; Zink, A.

    2015-01-01

    Exclusive production of ηπ- and η‧π- has been studied with a 191 GeV / cπ- beam impinging on a hydrogen target at COMPASS (CERN). Partial-wave analyses reveal different odd/even angular momentum (L) characteristics in the inspected invariant mass range up to 3 GeV /c2. A striking similarity between the two systems is observed for the L = 2 , 4 , 6 intensities (scaled by kinematical factors) and the relative phases. The known resonances a2 (1320) and a4 (2040) are in line with this similarity. In contrast, a strong enhancement of η‧π- over ηπ- is found for the L = 1 , 3 , 5 waves, which carry non- q q bar quantum numbers. The L = 1 intensity peaks at 1.7 GeV /c2 in η‧π- and at 1.4 GeV /c2 in ηπ-, the corresponding phase motions with respect to L = 2 are different.

  8. The virtual observatory service TheoSSA: Establishing a database of synthetic stellar flux standards. I. NLTE spectral analysis of the DA-type white dwarf G191-B2B

    Science.gov (United States)

    Rauch, T.; Werner, K.; Bohlin, R.; Kruk, J. W.

    2013-12-01

    Context. Hydrogen-rich, DA-type white dwarfs are particularly suited as primary standard stars for flux calibration. State-of-the-art NLTE models consider opacities of species up to trans-iron elements and provide reliable synthetic stellar-atmosphere spectra to compare with observations. Aims: We will establish a database of theoretical spectra of stellar flux standards that are easily accessible via a web interface. Methods: In the framework of the Virtual Observatory, the German Astrophysical Virtual Observatory developed the registered service TheoSSA. It provides easy access to stellar spectral energy distributions (SEDs) and is intended to ingest SEDs calculated by any model-atmosphere code. In case of the DA white dwarf G191-B2B, we demonstrate that the model reproduces not only its overall continuum shape but also the numerous metal lines exhibited in its ultraviolet spectrum. Results: TheoSSA is in operation and contains presently a variety of SEDs for DA-type white dwarfs. It will be extended in the near future and can host SEDs of all primary and secondary flux standards. The spectral analysis of G191-B2B has shown that our hydrostatic models reproduce the observations best at and log g = 7.60 ± 0.05. We newly identified Fe vi, Ni vi, and Zn iv lines. For the first time, we determined the photospheric zinc abundance with a logarithmic mass fraction of -4.89 (7.5 × solar). The abundances of He (upper limit), C, N, O, Al, Si, O, P, S, Fe, Ni, Ge, and Sn were precisely determined. Upper abundance limits of about 10% solar were derived for Ti, Cr, Mn, and Co. Conclusions: The TheoSSA database of theoretical SEDs of stellar flux standards guarantees that the flux calibration of all astronomical data and cross-calibration between different instruments can be based on the same models and SEDs calculated with different model-atmosphere codes and are easy to compare. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope

  9. BDML Metadata: 191 [SSBD[Archive

    Lifescience Database Archive (English)

    Full Text Available NC-SA 0.180 d800e60b-630a-4560-a005-80e673a1d25d 0.105 x 0.105 x 0.5 (micrometer), 40 (second) http://ssbd.qbic.riken.jp/data.../source/Ce_KK_P002/RNAi_T07C4.7_040831_02.zip http://ssbd.qbic.riken.jp/data.../bdml/Ce_KK_P002/RNAi_T07C4.7_040831_02.bdml0.18.xml http://ssbd.qbic.riken.jp/data/pdpml/Ce_KK_...P002.pdpml0.06.xml http://ssbd.qbic.riken.jp/search/d800e60b-630a-4560-a005-80e673a1d25d/ http://ssbd.qbic.riken.jp/omero/webclient/?show=dataset-96 ...

  10. 19 CFR 191.2 - Definitions.

    Science.gov (United States)

    2010-04-01

    ...(j)(2)), means physical or operational control of the merchandise, including ownership while in bailment, in leased facilities, in transit to, or in any other manner under the operational control of, the... relative value at the time of separation. (v) Schedule. A schedule means a document filed by a...

  11. 40 CFR 63.191 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Organic Hazardous Air Pollutants for Certain Processes Subject to the Negotiated Regulation for Equipment... units utilized to dissolve tetrachlorophthalic acid chloride in an organic solvent, typically carbon tetrachloride, with the subsequent addition of ammonia. Dacthal TM means the pre-emergent herbicide Dacthal...

  12. 19 CFR 191.32 - Substitution drawback.

    Science.gov (United States)

    2010-04-01

    ... recognized industrial standards, part numbers, tariff classification and value. A party may seek a nonbinding... corporate resolution: (i) All or substantially all of the rights, privileges, immunities, powers, duties... corporate resolution, provided for in paragraph (f)(2) of this section, and the records and...

  13. 19 CFR 191.9 - Agency.

    Science.gov (United States)

    2010-04-01

    ... compensation to show that the relationship is an agency rather than a sale; (ii) How transfers of merchandise... principal over the agent's performance of work; (v) The party who is to bear the risk of loss on the... principal's ownership interest under this section. (3) Sales prohibited. The relationship between...

  14. 49 CFR 191.3 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... individual, firm, joint venture, partnership, corporation, association, State, municipality, cooperative association, or joint stock association, and includes any trustee, receiver, assignee, or personal...) Estimated property damage, including cost of gas lost, of the operator or others, or both, of $50,000...

  15. 32 CFR 191.3 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... on race, color, national origin, religion, sex, age, or disability. Equal Employment Opportunity (EEO.... Has a history of, or has been misclassified as having, a mental or physical impairment that... Middle East. Religion. Traditional systems of religious belief and moral or ethical beliefs as to what...

  16. 32 CFR 191.6 - Procedures.

    Science.gov (United States)

    2010-07-01

    ... include Dr. Martin Luther King Jr.'s Birthday, Black History Month, National Women's History Week, Women's..., religion, national origin, mental or physical disability, or age. (14) Develop procedures for and...

  17. 40 CFR 191.12 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... ENVIRONMENTAL RADIATION PROTECTION STANDARDS FOR MANAGEMENT AND DISPOSAL OF SPENT NUCLEAR FUEL, HIGH-LEVEL AND... resource use, and (4) other methods of preserving knowledge about the location, design, and contents of a... capable of yielding a significant amount of water to a well or spring. Barrier means any material...

  18. 15 CFR 922.191 - Definitions.

    Science.gov (United States)

    2010-01-01

    .... Traditional fishing means those commercial, recreational, and subsistence fishing activities that were... Impact Statement and Management Plan for this Sanctuary. Copies of the Final Environmental Impact... Administration, 1305 East-West Highway, 11th Floor, Silver Spring, MD 20910, (301) 713-3125. Traditional...

  19. 19 CFR 191.42 - Procedure.

    Science.gov (United States)

    2010-04-01

    ... required in paragraph (b)(1) of this section. (c) Notice. A notice of intent to export or destroy... provided to the Customs Service to give Customs the opportunity to examine the merchandise. The claimant... Customs custody a Notice of Intent to Export, Destroy, or Return Merchandise for Purposes of Drawback...

  20. QTL Information Table: 191 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Physiological trait Source activity soluble protein ... content at 25days after heading RFLP C)Inter ... hsugi, R. (2001). Are contents of Rubisco, soluble protein ... and nitrogen in flag leaves of rice controlled by ...

  1. Effect of proton irradiation induced defects on intergranular and intragranular pinning in polycrystalline textured Bi2Sr2CaCu2O8+δ and Bi1.84Pb0.34Sr1.91Ca2.03Cu3.06O10+δ superconductors

    International Nuclear Information System (INIS)

    Proton irradiated polycrystalline textured Bi2Sr2CaCu2O8+δ (Bi-2212) and Bi1.84Pb0.34Sr1.91 Ca2.03Cu3.06 O10+δ(Bi-2223) samples have been studied with respect to pinning and its correlation with irradiation induced defects characterised by Positron annihilation spectroscopy. Intergranular and intragranular pinning behaviours have been analysed through minor and major hysteresis loops respectively in DC magnetization at different fields. The sharp fall in the critical current density (Jco) at high dose of Bi-2223 as compared to Bi-2212 has been observed. (author)

  2. Survival of Escherichia coli O157:H7 in full- and reduced-fat pepperoni after manufacture of sticks, storage of slices at 4 degrees C or 21 degrees C under air and vacuum, and baking of slices on frozen pizza at 135, 191 and 246 degrees C.

    Science.gov (United States)

    Faith, N G; Wierzba, R K; Ihnot, A M; Roering, A M; Lorang, T D; Kaspar, C W; Luchansky, J B

    1998-04-01

    Pepperoni batter was prepared with fat contents of about 15, 20, and 32% (wt/wt) and inoculated with a pediococcal starter culture and > or = 2.0 x 10(7) CFU/g of a five-strain inoculum of Escherichia coli O157:H7. The batter was fermented at 96 degrees F (ca. 36 degrees C and 85% relative humidity (RH) to pH cheese pizzas that were subsequently baked at 275 degrees F (ca. 135 degrees C), 375 degrees F (ca. 191 degrees C), or 475 degrees F (ca. 246 degrees C) for 0 to 20 min. Appreciable differences related to fat levels were observed after drying; pathogen numbers decreased by 1.04, 1.31 and 1.62 log10 units in sticks prepared from batter at initial fat levels of 15, 20, and 32%, respectively. During storage, the temperature rather than the atmosphere had the greater effect on pathogen numbers, with similar viability observed among the three fat levels tested. At 70 degrees F (ca. 21 degrees C), compared to original levels, pathogen numbers decreased by > or = 5.56 and > or = 4.53 log10 units within 14 days in slices stored under air and vacuum, respectively, whereas at 39 degrees F (ca. 4 degrees C) numbers decreased by pizza at 475 degrees F (ca. 246 degrees C) for 10 min or at 375 degrees F (ca. 191 degrees C) for 15 min. The calculated D values for all three temperatures tested increased as the fat content of the batter increased from 15 to 20 to 32%. The present study confirmed that fermentation and drying were sufficient to reduce levels of E. coli O157:H7 in pepperoni sticks by 5.5-log10-unit total reduction of the pathogen. Baking slices on frozen pizza for at least 15 min at 475 degrees F (ca. 246 degrees C) or 20 min at 375 degrees F (ca. 191 degrees C) was necessary to reduce pathogen numbers to below detection by both direct plating and enrichment. PMID:9709198

  3. Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2013-09-01

    Full Text Available A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1 dissolution of bismuth target in conc. HNO3; (2 removal of the HNO3 by distillation; (3 dissolution of residue in 8 M HCl; (4 extraction of 211At from 8 M HCl into DIPE; and (5 extraction of 211At from DIPE into NaOH. Results from 55 “optimized” 211At isolation runs gave recovery yields of approximately 78% after decay and attenuation corrections. An attenuation-corrected average of 26 ± 3 mCi in the target provided isolated (actual yields of 16 ± 3 mCi of 211At. A sixth step, used for purification of 211At from trace metals, was evaluated in seven runs. In those runs, isolated 211At was distilled under reductive conditions to provide an average 71 ± 8% recovery. RadioHPLC analyses of the isolated 211At solutions, both initial and after distillation, were obtained to examine the 211At species present. The primary species of 211At present was astatide, but astatate and unidentified species were also observed. Studies to determine the effect of bismuth attenuation on 211At were conducted to estimate an attenuation factor (~1.33 for adjustment of 211At readings in the bismuth target.

  4. Final Report for grant entitled "Production of Astatine-211 for U.S. Investigators"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, Daniel Scott

    2012-12-12

    Alpha-particle emitting radionuclides hold great promise in the therapy of cancer, but few alpha-emitters are available to investigators to evaluate. Of the alpha-emitters that have properties amenable for use in humans, 211At is of particular interest as it does not have alpha-emitting daughter radionuclides. Thus, there is a high interest in having a source of 211At for sale to investigators in the US. Production of 211At is accomplished on a cyclotron using an alpha-particle beam irradiation of bismuth metal. Unfortunately, there are few cyclotrons available that can produce an alpha particle beam for that production. The University of Washington has a cyclotron, one of three in the U.S., that is currently producing 211At. In the proposed studies, the things necessary for production and shipment of 211At to other investigators will be put into place at UW. Of major importance is the efficient production and isolation of 211At in a form that can be readily used by other investigators. In the studies, production of 211At on the UW cyclotron will be optimized by determining the best beam energy and the highest beam current to maximize 211At production. As it would be very difficult for most investigators to isolate the 211At from the irradiated target, the 211At-isolation process will be optimized and automated to more safely and efficiently obtain the 211At for shipment. Additional tasks to make the 211At available for distribution include obtaining appropriate shipping vials and containers, putting into place the requisite standard operating procedures for Radiation Safety compliance at the levels of 211At activity to be produced / shipped, and working with the Department of Energy, Isotope Development and Production for Research and Applications Program, to take orders, make shipments and be reimbursed for costs of production and shipment.

  5. Astatination of nanoparticles containing silver as possible carriers of 211At

    Czech Academy of Sciences Publication Activity Database

    Lebeda, Ondřej; Kučka, Jan; Hrubý, Martin; Koňák, Čestmír; Kozempel, Ján

    2006-01-01

    Roč. 64, - (2006), s. 201-206. ISSN 0969-8043 R&D Projects: GA AV ČR KJB4048302; GA AV ČR KJB4050408 Institutional research plan: CEZ:AV0Z1048901 Keywords : nanoparticles * 211AT * Atalpha particle therapy Subject RIV: CH - Nuclear ; Quantum Chemistry Impact factor: 0.924, year: 2006

  6. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven major subsystems that comprise the CS-30 Cyclotron. With these modifications in place, routine production of ≥200 mCi of At-211 should be readily achievable, given our methodological development of At-211 target preparation, internal target irradiation and dry distillation to recover the radionuclide.

  7. The study of inter and intragranular pinning behavior of oxygen irradiated textured polycrystalline Bi2Sr2CaCu2O8+δ and Bi1.84Pb0.34Sr1.91Ca2.03Cu3.06O10+δ superconductors

    International Nuclear Information System (INIS)

    Inter and intragranular pinning potentials of 116 MeV oxygen ion irradiated textured polycrystalline Bi2Sr2CaCu2O8+δ (Bi-2212) and Bi1.84Pb0.34Sr1.91Ca2.03Cu3.06O10+δ (Bi-2223) have been studied from dc magnetization at low (50 Oe) and high (10,000 Oe) fields respectively. There is an increase in intergranular pinning potential (U0) in Bi-2223 in contrast to anomalous decreases in Bi-2212 with increasing dislocation density. Intragranular pinning potential is governed by the concentration of vacancy type defects rather than its size as observed in proton irradiation. Pinning has been explained in the light of statistical dilute pinning model

  8. The study of inter and intragranular pinning behavior of oxygen irradiated textured polycrystalline Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub 8+{delta}} and Bi{sub 1.84}Pb{sub 0.34}Sr{sub 1.91}Ca{sub 2.03}Cu{sub 3.06}O{sub 10+{delta}} superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Sen, Pintu; Bandyopadhyay, S.K.; Nambissan, P.M.G.; Ganguly, R.; Barat, P.; Mukherjee, P

    2004-08-01

    Inter and intragranular pinning potentials of 116 MeV oxygen ion irradiated textured polycrystalline Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub 8+{delta}} (Bi-2212) and Bi{sub 1.84}Pb{sub 0.34}Sr{sub 1.91}Ca{sub 2.03}Cu{sub 3.06}O{sub 10+{delta}} (Bi-2223) have been studied from dc magnetization at low (50 Oe) and high (10,000 Oe) fields respectively. There is an increase in intergranular pinning potential (U{sub 0}) in Bi-2223 in contrast to anomalous decreases in Bi-2212 with increasing dislocation density. Intragranular pinning potential is governed by the concentration of vacancy type defects rather than its size as observed in proton irradiation. Pinning has been explained in the light of statistical dilute pinning model.

  9. Dicty_cDB: SHC191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available mRNA sequence. 56 0.001 1 CV682907 |CV682907.1 service43_H06_sjs2-16-2B11-T3 SJS Schistosoma japonicum cDNA,... mRNA sequence. 56 0.001 1 CV682854 |CV682854.1 service30_G09_sjs2-14-10C09-T3 SJ

  10. 7 CFR 1.191 - Net worth exhibit.

    Science.gov (United States)

    2010-01-01

    ... association, must provide with its application a detailed exhibit showing the net worth of the applicant and... information in any portion of the exhibit and believes there are legal grounds for withholding it from... counsel representing the agency against which the applicant seeks an award, but need not be served on...

  11. Dicty_cDB: SSD191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available MFSKYKYLVIEPNQTXDCN KLFLLESLVISYNSPINENSLFEHTQITPGNILPFYQVPLLPKV*tlkekekkk Homology vs CSM-cDNA Score E Sequ...TLFLKSFYYSHTQKKFLQNIHNQFLFRDVIFSTKLIGEKGSVLSVGFLGRIIFLIL PFFIQLNVIYDKNPSINTFIVGYLITAIFILVWFSILKTLVMFSKYKYLVI...EPNQTXDCN KLFLLESLVISYNSPINENSLFEHTQITPGNILPFYQVPLLPKV*tlkekekkk Translated Amino Acid sequence (All Frames)

  12. Accelerated fatigue testing of LM 19.1 blades

    DEFF Research Database (Denmark)

    Kristensen, Ole Jesper Dahl; Jørgensen, E.

    2003-01-01

    material. In addition to the thermal imaging surveillance the blades were instrumented with strain gauges. This report presents the temperature duringtest, calibration test results, moment range measurements, strain statistics, thermal imaging registrations and a determination of the size and cause of the...

  13. Dicty_cDB: SHE191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available strand read from insert in 3'HPRT insertion targeting and chromosome engineering clone MHPP186g09. 50 0.063 ...sert in 3'HPRT insertion targeting and chromosome engineering clone MHPP47e19. 50 0.063 1 CR034434 |CR034434....1 Forward strand read from insert in 3'HPRT insertion targeting and chromosome engineering clone MHPP47e19....ion targeting and chromosome engineering clone MHPP142o16. 50 0.063 1 dna update 2006. 2.10 Homology vs Prot...1 CR023465 |CR023465.1 Forward strand read from insert in 3'HPRT insertion targeting and chromosome engine

  14. 22 CFR 191.22 - Administration of benefits.

    Science.gov (United States)

    2010-04-01

    ... the Office for authorized travel to obtain an evaluation of their claim under paragraph (b) of this section and for other authorized travel to obtain medical or health care authorized by this subpart....

  15. Dicty_cDB: SHB191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available fcwylyfimerrfrfnr*ts*s*kd*ss*vshveleerfrketssl* sfpsn*igq*k**csrikw*t*g*tifpyfkqri*yh*kfktfpskyyplcc*ylgydec...*wcyqesfni*fleprdlmkpvrvvhhfg* kllifgelnklslvllvlifhhgekvplqslnflklerlvvis*pcgigreis*rnq*fv kfsvklnwsmkmimle...vpkgnefsiigiwhnkwrsk i*yig*s*y*fsrdgrenastqgiprattattttatttkakr*rvvitkeetiinaik*k etcrqrrf*nirdnhw...*re--- ---sinyeyldctnrckrsnhfhsrrydscngvtkshsiyds*sqetl*sr*ewsitlgr sy*sles*tnflw...discoideum cellulose synthase (dcsA) mRNA, complete cds. 1102 0.0 2 AC006097 |AC0

  16. Dicty_cDB: SSB191 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available cDNA clone Gm-r1088-7599 3', mRNA sequence. 50 5e-04 2 AW738663 |AW738663.1 EST340090 tomato flower buds, anthesis, Cornell...quence. 44 0.027 2 AW737094 |AW737094.1 EST338521 tomato flower buds, anthesis, Cornell University Lycopersi...con esculentum cDNA clone cTOD2E1 5', mRNA sequence. 44 0.041 2 AW737942 |AW737942.1 EST339369 tomato flower buds, anthesis, Cornell

  17. 47 CFR 0.191 - Functions of the Bureau.

    Science.gov (United States)

    2010-10-01

    ... Service Priority System. Supports the Chiefs of the Wireline Competition, International and Wireless... facilities; satellite and wireless radio services; radio frequency assignment; electro-magnetic radiation... security, national security, emergency management and preparedness, and disaster management...

  18. Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

    Energy Technology Data Exchange (ETDEWEB)

    Green, Damian J.; Shadman, Mazyar; Jones, Jon C.; Frayo, Shani; Kenoyer, Aimee L.; Hylarides, Mark; Hamlin, Donald K.; Wilbur, D. Scott; Balkan, Ethan R.; Lin, Yukang; Miller, Brian W.; Frost, Sophia; Gopal, Ajay K.; Orozco, Johnnie J.; Gooley, Ted; Laird, Kelley L.; Till, B. G.; Back, Tom; Sandmaier, B. M.; Pagel, John M.; Press, Oliver W.

    2015-03-26

    Alpha emitting radionuclides release a large amount of energy within a few cell diameters and may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD) conditions in which micrometastatic disease satellites are broadly distributed. To evaluate this hypothesis, 211At conjugated 1F5 mAb (anti-CD20) was studied in both bulky lymphoma tumor xenograft and MRD animal models. Superior treatment responses to 211At conjugated 1F5 mAb were evident in the MRD setting. Lymphoma xenograft tumor bearing animals treated with doses of up to 48µCi of anti-CD20 211At-decaborate [211At-B10-1F5] experienced modest responses (0% cures but 2-3-fold prolongation of survival compared to negative controls). In contrast, 70% of animals in the MRD lymphoma model demonstrated complete eradication of disease when treated with 211At-B10-1F5 at a radiation dose that was less than one-third (15 µCi) of the highest dose given to xenograft animals. Tumor progression among untreated control animals in both models was uniformly lethal. After 130 days, no significant renal or hepatic toxicity is observed in the cured animals receiving 15 µCi of 211At-B10-1F5. These findings suggest that in a MRD lymphoma model, where isolated cells and tumor microclusters prevail, α-emitters may be uniquely efficacious.

  19. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE,CERN

    OpenAIRE

    Rothe, Sebastian

    2012-01-01

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spec...

  20. Inactivation of human osteosarcoma cells in vitro by {sup 211}At-TP-3 monoclonal antibody: Comparison with astatine-211 and external-beam X rays

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, R.H. [Univ. of Oslo (Norway)]|[Institute for Cancer Research, Oslo (Norway); Bruland, O.S. [Institute for Cancer Research, Oslo (Norway); Hoff, P.; Alstad, J. [Univ. of Oslo (Norway); Lindmo, T. [Institute for Cancer Research, Oslo (Norway); Rofstad, E.K. [Norwegian Institute of Technology, Trondheim (Norway)

    1994-08-01

    The potential usefulness of {alpha}-particle radioimmunotherapy in the treatment of osteosarcoma was studied in vitro by using the monoclonal antibody TP-3 and cells of three human osteosarcoma cell lines (OHS, SAOS and KPDX) differing in antigen expression. Cell survival curves were established after treatment with (a) {sup 211}At-TP-3 of different specific activities, (b) {sup 211}At-labeled bovine serum albumin (BSA), (c) free {sup 211}At and (d) external-beam X rays. The three osteosarcoma cell lines showed similar survival curves, whether treated with external-beam X rays, {sup 211}At-BSA or free {sup 211}At. The D{sub o}`s were lower for free {sup 211}At than for {sup 211}At-BSA. The survival curves for {sup 211}At-TP-3 treatment, on the other hand, differed significantly among the cell lines, suggesting that sensitivity to {sup 211}At-TP-3 treatment was governed by cellular properties other than sensitivity to external-beam X rays. The cellular property most important for sensitivity to {sup 211}At-TP-3 treatment was the antigen expression. Cell inactivation after {sup 211}At-TP-3 treatment increased substantially with increasing specific activity of the {sup 211}At-TP-3. At high specific activities, the cytotoxic effect of {sup 211}At-TP-3 was significantly higher than that of {sup 211}At-BSA. In conclusion, {sup 211}At-TP-3 has the potential to give clinically favorable therapeutic ratios in the treatment of osteosarcoma. 39 refs., 5 figs., 2 tabs.

  1. SU-E-T-191: First Principle Calculation of Quantum Yield in Photodynamic Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Abolfath, R; Guo, F; Chen, Z; Nath, R [Yale New Haven Hospital, New Haven, CT (United States)

    2014-06-01

    Purpose: We present a first-principle method to calculate the spin transfer efficiency in oxygen induced by any photon fields especially in MeV energy range. The optical pumping is mediated through photosensitizers, e.g., porphyrin and/or ensemble of quantum dots. Methods: Under normal conditions, oxygen molecules are in the relatively non-reactive triplet state. In the presence of certain photosensitizer compounds such as porphyrins, electromagnetic radiation of specific wavelengths can excite oxygen to highly reactive singlet state. With selective uptake of photosensitizers by certain malignant cells, photon irradiation of phosensitized tumors can lead to selective killing of cancer cells. This is the basis of photodynamic therapy (PDT). Despite several attempts, PDT has not been clinically successful except in limited superficial cancers. Many parameters such as photon energy, conjugation with quantum dots etc. can be potentially combined with PDT in order to extend the role of PDT in cancer management. The key quantity for this optimization is the spin transfer efficiency in oxygen by any photon field. The first principle calculation model presented here, is an attempt to fill this need. We employ stochastic density matrix description of the quantum jumps and the rate equation methods in quantum optics based on Markov/Poisson processes and calculate time evolution of the population of the optically pumped singlet oxygen. Results: The results demonstrate the feasibility of our model in showing the dependence of the optical yield in generating spin-singlet oxygen on the experimental conditions. The adjustable variables can be tuned to maximize the population of the singlet oxygen hence the efficacy of the photodynamic therapy. Conclusion: The present model can be employed to fit and analyze the experimental data and possibly to assist researchers in optimizing the experimental conditions in photodynamic therapy.

  2. Health (Radiation Safety) Regulations 1984 (Victoria), No. 191 of 8 May 1984

    International Nuclear Information System (INIS)

    These Regulations promulgated pursuant to the Health Act 1958, as amended, repeal the Irradiating Apparatus and Radioactive Substances Regulations 1959. The provisions of the Regulations are designed to safeguard the public, patients and employees of registered premises from harmful effects of radiation. (NEA)

  3. Yeast Interacting Proteins Database: YPR105C, YPR191W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YPR105C COG4 Essential component of the conserved oligomeric Golgi complex (Cog1p t...cription Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tether... path with 1 intervening protein (YPD) 0 Alternative path with 2 intervening proteins (YPD) 0 IST hit 3 IST hit in the opposite bait/prey orientation - ... ...hrough Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles...nt of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulate

  4. People and things. CERN Courier, Mar 1979, v. 19(1)

    International Nuclear Information System (INIS)

    The article reports on various achievements of CERN staff members and gives news updates on upcoming or past events, for example the First Workshop on Ultra-Relativistic Nuclear Collisions, or the CERN 25th Anniversary Celebrations

  5. SU-E-J-191: Motion Prediction Using Extreme Learning Machine in Image Guided Radiotherapy

    International Nuclear Information System (INIS)

    Purpose: Real-time motion tracking is a critical issue in image guided radiotherapy due to the time latency caused by image processing and system response. It is of great necessity to fast and accurately predict the future position of the respiratory motion and the tumor location. Methods: The prediction of respiratory position was done based on the positioning and tracking module in ARTS-IGRT system which was developed by FDS Team (www.fds.org.cn). An approach involving with the extreme learning machine (ELM) was adopted to predict the future respiratory position as well as the tumor’s location by training the past trajectories. For the training process, a feed-forward neural network with one single hidden layer was used for the learning. First, the number of hidden nodes was figured out for the single layered feed forward network (SLFN). Then the input weights and hidden layer biases of the SLFN were randomly assigned to calculate the hidden neuron output matrix. Finally, the predicted movement were obtained by applying the output weights and compared with the actual movement. Breathing movement acquired from the external infrared markers was used to test the prediction accuracy. And the implanted marker movement for the prostate cancer was used to test the implementation of the tumor motion prediction. Results: The accuracy of the predicted motion and the actual motion was tested. Five volunteers with different breathing patterns were tested. The average prediction time was 0.281s. And the standard deviation of prediction accuracy was 0.002 for the respiratory motion and 0.001 for the tumor motion. Conclusion: The extreme learning machine method can provide an accurate and fast prediction of the respiratory motion and the tumor location and therefore can meet the requirements of real-time tumor-tracking in image guided radiotherapy

  6. SU-E-J-191: Motion Prediction Using Extreme Learning Machine in Image Guided Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Jia, J; Cao, R; Pei, X; Wang, H; Hu, L [Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); Engineering Technology Research Center of Accurate Radiotherapy of Anhui Province, Hefei 230031 (China); Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, SuZhou (China)

    2015-06-15

    Purpose: Real-time motion tracking is a critical issue in image guided radiotherapy due to the time latency caused by image processing and system response. It is of great necessity to fast and accurately predict the future position of the respiratory motion and the tumor location. Methods: The prediction of respiratory position was done based on the positioning and tracking module in ARTS-IGRT system which was developed by FDS Team (www.fds.org.cn). An approach involving with the extreme learning machine (ELM) was adopted to predict the future respiratory position as well as the tumor’s location by training the past trajectories. For the training process, a feed-forward neural network with one single hidden layer was used for the learning. First, the number of hidden nodes was figured out for the single layered feed forward network (SLFN). Then the input weights and hidden layer biases of the SLFN were randomly assigned to calculate the hidden neuron output matrix. Finally, the predicted movement were obtained by applying the output weights and compared with the actual movement. Breathing movement acquired from the external infrared markers was used to test the prediction accuracy. And the implanted marker movement for the prostate cancer was used to test the implementation of the tumor motion prediction. Results: The accuracy of the predicted motion and the actual motion was tested. Five volunteers with different breathing patterns were tested. The average prediction time was 0.281s. And the standard deviation of prediction accuracy was 0.002 for the respiratory motion and 0.001 for the tumor motion. Conclusion: The extreme learning machine method can provide an accurate and fast prediction of the respiratory motion and the tumor location and therefore can meet the requirements of real-time tumor-tracking in image guided radiotherapy.

  7. 40 CFR Appendix A to Part 191 - Table for Subpart B

    Science.gov (United States)

    2010-07-01

    ...-90 1,000 Technetium-99 10,000 Thorium-230 or -232 10 Tin-126 1,000 Uranium-233, -234, -235, -236, or... quantities in Table 1 multiplied by 55: ec11no91.000 Note 3: Adjustments for Reactor Fuels with Different Burnup. For disposal systems containing reactor fuels (or the high-level wastes from reactor...

  8. Yeast Interacting Proteins Database: YBL045C, YPR191W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available Rows with this prey as prey Rows with this prey as prey (2) Rows with this prey as bait Rows with this prey as bait (1) Literature... on bait (YPD) 27 Literature on prey (YPD) 23 Literature sh...ared by bait and prey 14 Literature sharing score 89 CuraGen (0 or 1) 0 S. Fields (0 or 1) 0 Association (0

  9. Yeast Interacting Proteins Database: YIL103W, YKL191W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YIL103W DPH1 Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diph ... thamide, which is a modified histidine ... residue of translation elongation factor 2 (Eft1p ... for synthesis of diphthamide, which is a modified histidine ... residue of translation elongation factor 2 (Eft1p ...

  10. Photo grafting of Polyacrylamide Hydrogel Coating onto Various Polyethylene Terephthalate Textiles, V. 19(1)

    International Nuclear Information System (INIS)

    In this paper, polyacrylamide (PAAm) hydrogels grafted via photo polymerization onto various types of polyethylene terephthalate (PET) as matrix were designed and synthesized. The investigation was carried out based on thickness (0.02 -0.07 mm) of nonwoven PET textiles from various resources as well as commercial PET membrane. In this study, PET matrices with a disk shape of 4.5 cm in diameter were coated with thin hydrogel using UVA photo polymerization system. The resulting grafted PAAm-g-PET was examined through degree of grafting (DG) and characterized by using Fourier Transformed Infrared Spectroscopy (FTIR). The DG above 50 % results showed the ability of PAAm hydrogel to be grafted onto PET. The various range of thickness and surface of PET also gave an impact onto the performance of grafting of PAAm onto PET. FTIR results also confirmed the addition of amide group after grafting process (1720 cm-1, 1100 cm-1, 850 cm-1). The hydrophilicity of hydrogels was reported to impart oil fouling resistance. We expect that grafted hydrogel layer has fascinating future for oil/ water separation. (author)

  11. 76 FR 24925 - Solicitation for Public Comment on Potential Alternatives To Resolve Generic Safety Issue 191...

    Science.gov (United States)

    2011-05-03

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY... NRC Web site and on the Federal rulemaking Web site, http://www.regulations.gov . Because your... Site: Go to http://www.regulations.gov and search for documents filed under Docket ID NRC-...

  12. 19 CFR 191.35 - Notice of intent to export; examination of merchandise.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Notice of intent to export; examination of... intent to export; examination of merchandise. (a) Notice. A notice of intent to export merchandise which... Customs Service to give Customs the opportunity to examine the merchandise. The claimant, or the...

  13. 19 CFR 191.91 - Waiver of prior notice of intent to export.

    Science.gov (United States)

    2010-04-01

    ... by this application; (D) Commodity/product lines of imported and exported merchandise covered by this... parties involved in the import and export transactions; (ii) A written declaration whether or not the... intent to export, under this section, shall operate prospectively, applying only to those...

  14. 36 CFR 223.191 - Sourcing area disapproval and review procedures.

    Science.gov (United States)

    2010-07-01

    ... OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER The Forest Resources Conservation... knowledge and understanding of the requirements of the Forest Resources Conservation and Shortage Relief Act... disapproved sourcing area in the past 24 months, pursuant to the Forest Resources Conservation and...

  15. Chemical effects head-loss research in support of generic safety issue 191.

    Energy Technology Data Exchange (ETDEWEB)

    Park, J. H.; Kasza, K.; Fisher, B.; Oras, J.; Natesan, K.; Shack, W. J.; Nuclear Engineering Division

    2006-10-31

    This summary report describes studies conducted at Argonne National Laboratory on the potential for chemical effects on head loss across sump screens. Three different buffering solutions were used for these tests: trisodium phosphate (TSP), sodium hydroxide, and sodium tetraborate. These pH control agents used following a LOCA at a nuclear power plant show various degrees of interaction with the insulating materials Cal-Sil and NUKON. Results for Cal-Sil dissolution tests in TSP solutions, settling rate tests of calcium phosphate precipitates, and benchmark tests in chemically inactive environments are also presented. The dissolution tests were intended to identify important environmental variables governing both calcium dissolution and subsequent calcium phosphate formation over a range of simulated sump pool conditions. The results from the dissolution testing were used to inform both the head loss and settling test series. The objective of the head loss tests was to assess the head loss produced by debris beds created by Cal-Sil, fibrous debris, and calcium phosphate precipitates. The effects of both the relative arrival time of the precipitates and insulation debris and the calcium phosphate formation process were specifically evaluated. The debris loadings, test loop flow rates, and test temperature were chosen to be reasonably representative of those expected in plants with updated sump screen configurations, although the approach velocity of 0.1 ft/s used for most of the tests is 3-10 times that expected in plants with large screens . Other variables were selected with the intent to reasonably bound the head loss variability due to arrival time and calcium phosphate formation uncertainty. Settling tests were conducted to measure the settling rates of calcium phosphate precipitates (formed by adding dissolved Ca to boric acid and TSP solutions) in water columns having no bulk directional flow. For PWRs where NaOH and sodium tetraborate are used to control sump pH and fiberglass insulation is prevalent, relatively high concentrations of soluble aluminum can be expected. Tests in which the dissolved aluminum (Al) resulted from aluminum nitrate additions were used to investigate potential chemical effects that may lead to high head loss. Dissolved Al concentrations of 100 ppm were shown to lead to large pressure drops for the screen area to sump volume ratio and fiber debris bed studied. No chemical effects on head loss were observed in sodium tetraborate buffered solutions even for environments with high ratios of submerged Al area to sump volume. However, in tests with much higher concentrations of dissolved Al than expected in plants, large pressure drops did occur. Interaction with NUKON/Cal-Sil debris mixtures produced much lower head losses than observed in corresponding tests with TSP, although tests were not performed over the full range of Cal-Sil that might be of interest.

  16. Yves Besson, Identité et conflits au Proche-Orient, Paris, L'Harmattan, 1990, 191 p.

    OpenAIRE

    Dieckhoff, Alain

    2005-01-01

    Dans ce livre dense et riche, l'auteur s'appuie sur le concept d'identité, défini comme une représentation de soi, nécessairement plurielle et, en partie au moins, imaginée pour en faire une des clés des conflits proche-orientaux. Il applique ensuite cette grille de lecture à trois cas : l'Arabie Séoudite, le Liban et Israël.

  17. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 3: Appendix BIR Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    The Waste Isolation Pilot Plant (WIPP) Transuranic Waste Baseline Inventory Report (WTWBIR) establishes a methodology for grouping wastes of similar physical and chemical properties, from across the US Department of Energy (DOE) transuranic (TRU) waste system, into a series of ``waste profiles`` that can be used as the basis for waste form discussions with regulatory agencies. The majority of this document reports TRU waste inventories of DOE defense sites. An appendix is included which provides estimates of commercial TRU waste from the West Valley Demonstration Project. The WIPP baseline inventory is estimated using waste streams identified by the DOE TRU waste generator/storage sites, supplemented by information from the Mixed Waste Inventory Report (MWIR) and the 1994 Integrated Data Base (IDB). The sites provided and/or authorized all information in the Waste Stream Profiles except the EPA (hazardous waste) codes for the mixed inventories. These codes were taken from the MWIR (if a WTWBIR mixed waste stream was not in MWIR, the sites were consulted). The IDB was used to generate the WIPP radionuclide inventory. Each waste stream is defined in a waste stream profile and has been assigned a waste matrix code (WMC) by the DOE TRU waste generator/storage site. Waste stream profiles with WMCs that have similar physical and chemical properties can be combined into a waste matrix code group (WMCG), which is then documented in a site-specific waste profile for each TRU waste generator/storage site that contains waste streams in that particular WMCG.

  18. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 4: Appendix BIR Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    This report consists of the waste stream profile for the WIPP transuranic waste baseline inventory at Lawrence Livermore National Laboratory. The following assumptions/modifications were made by the WTWBIR team in developing the LL waste stream profiles: since only current volumes were provided by LL, the final form volumes were assumed to be the same as the current volumes; the WTWBIR team had to assign identification numbers (IDs) to those LL waste streams not given an identifier by the site, the assigned identification numbers are consistent with the site reported numbers; LL Final Waste Form Groups were modified to be consistent with the nomenclature used in the WTWBID, these changes included word and spelling changes, the assigned Final Waste Form Groups are consistent with the information provided by LL; the volumes for the year 1993 were changed from an annual rate of generation (m{sup 3}/year) to a cumulative value (m{sup 3}).

  19. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 7: Appendix GCR Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    This report contains the second part of the geological characterization report for the Waste Isolation Pilot Plant. Both hydrology and geochemistry are evaluated. The following aspects of hydrology are discussed: surface hydrology; ground water hydrology; and hydrology drilling and testing. Hydrologic studies at the site and adjacent site areas have concentrated on defining the hydrogeology and associated salt dissolution phenomena. The geochemical aspects include a description of chemical properties of geologic media presently found in the surface and subsurface environments of southeastern New Mexico in general, and of the proposed WIPP withdrawal area in particular. The characterization does not consider any aspect of artificially-introduced material, temperature, pressure, or any other physico-chemical condition not native to the rocks of southeastern New Mexico.

  20. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 3: Appendix BIR Volume 1

    International Nuclear Information System (INIS)

    The Waste Isolation Pilot Plant (WIPP) Transuranic Waste Baseline Inventory Report (WTWBIR) establishes a methodology for grouping wastes of similar physical and chemical properties, from across the US Department of Energy (DOE) transuranic (TRU) waste system, into a series of ''waste profiles'' that can be used as the basis for waste form discussions with regulatory agencies. The majority of this document reports TRU waste inventories of DOE defense sites. An appendix is included which provides estimates of commercial TRU waste from the West Valley Demonstration Project. The WIPP baseline inventory is estimated using waste streams identified by the DOE TRU waste generator/storage sites, supplemented by information from the Mixed Waste Inventory Report (MWIR) and the 1994 Integrated Data Base (IDB). The sites provided and/or authorized all information in the Waste Stream Profiles except the EPA (hazardous waste) codes for the mixed inventories. These codes were taken from the MWIR (if a WTWBIR mixed waste stream was not in MWIR, the sites were consulted). The IDB was used to generate the WIPP radionuclide inventory. Each waste stream is defined in a waste stream profile and has been assigned a waste matrix code (WMC) by the DOE TRU waste generator/storage site. Waste stream profiles with WMCs that have similar physical and chemical properties can be combined into a waste matrix code group (WMCG), which is then documented in a site-specific waste profile for each TRU waste generator/storage site that contains waste streams in that particular WMCG

  1. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 7: Appendix GCR Volume 2

    International Nuclear Information System (INIS)

    This report contains the second part of the geological characterization report for the Waste Isolation Pilot Plant. Both hydrology and geochemistry are evaluated. The following aspects of hydrology are discussed: surface hydrology; ground water hydrology; and hydrology drilling and testing. Hydrologic studies at the site and adjacent site areas have concentrated on defining the hydrogeology and associated salt dissolution phenomena. The geochemical aspects include a description of chemical properties of geologic media presently found in the surface and subsurface environments of southeastern New Mexico in general, and of the proposed WIPP withdrawal area in particular. The characterization does not consider any aspect of artificially-introduced material, temperature, pressure, or any other physico-chemical condition not native to the rocks of southeastern New Mexico

  2. Discourse analysis of the National Policy for Health Promotion - doi:10.5020/18061230.2011.p191

    Directory of Open Access Journals (Sweden)

    Aline Raddatz

    2012-01-01

    Full Text Available Objective: To analyze the characteristics of the perspectives of Health Promotion present in the proposals of the actual National Policy for Health Promotion (PNPS. Methods: We conducted a qualitative, exploratory and documental study using the methodological procedures of the Collective Subject Discourse (CSD in the period of October 2009 to June 2010. Results: There were five Central-Ideas related to three different Anchorages. The DSC connected to Central-Ideas: (1 Spreading and introducing the PNPS; (3 Organizing and introducing proceedings targeting individual risk factors; and (4 Monitoring and controlling damages and risk factor, showed to be linked to Behavioral and/or Biomedical Approaches of Health Promotion. The DSC connected to Central-Ideas: (2 Discussing and Evaluating the PNPS and (5 Organizing and introducing proceedings for sustainable development reflected a Socio-Environmental Approach of Health Promotion. Conclusion: It was possible to verify the complexity of a set of proposals that reflect different perspectives of Health Promotion, considering that the Socio-Environmental approach, although not predominant in the PNPS, can be the most effective and according to the Unified Health System (SUS

  3. Teoría y Técnicas en la Investigación Educacional. Lima: Ave, 1987; 191 p.

    OpenAIRE

    Teresa| Cisneros

    1992-01-01

    El libro de la Dra. Irma Encinas constituye una lectura obligada para los estudiantes de educación y para los docentes que se inician en el campo de la investigación. Como su título lo indica, el libro está centrado en la presentación de la teoría y técnicas para la investigación educacional, constituyendo una herramienta eficaz para los que nos desempeñamos en el ámbito educativo. El documento, sin descuidar el aspecto científico, presenta de manera sistemáticamente didáctica los diversos pa...

  4. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 6: Appendix GCR Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    The Geological Characterization Report (GCR) for the WIPP site presents, in one document, a compilation of geologic information available to August, 1978, which is judged to be relevant to studies for the WIPP. The Geological Characterization Report for the WIPP site is neither a preliminary safety analysis report nor an environmental impact statement; these documents, when prepared, should be consulted for appropriate discussion of safety analysis and environmental impact. The Geological Characterization Report of the WIPP site is a unique document and at this time is not required by regulatory process. An overview is presented of the purpose of the WIPP, the purpose of the Geological Characterization Report, the site selection criteria, the events leading to studies in New Mexico, status of studies, and the techniques employed during geological characterization.

  5. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 6: Appendix GCR Volume 1

    International Nuclear Information System (INIS)

    The Geological Characterization Report (GCR) for the WIPP site presents, in one document, a compilation of geologic information available to August, 1978, which is judged to be relevant to studies for the WIPP. The Geological Characterization Report for the WIPP site is neither a preliminary safety analysis report nor an environmental impact statement; these documents, when prepared, should be consulted for appropriate discussion of safety analysis and environmental impact. The Geological Characterization Report of the WIPP site is a unique document and at this time is not required by regulatory process. An overview is presented of the purpose of the WIPP, the purpose of the Geological Characterization Report, the site selection criteria, the events leading to studies in New Mexico, status of studies, and the techniques employed during geological characterization

  6. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 2: Appendices, AAC, BECR, BH

    International Nuclear Information System (INIS)

    This report describes the conceptual design of a system the Department of Energy (DOE) may implement for compliance with the requirement to control access to the disposal site. In addition, this report addresses the scheduling process for control of inspection, maintenance, and periodic reporting related to Long Term Monitoring which addresses the monitoring of disposal system performance, environmental monitoring in accordance with the Consultation and Cooperation Agreement between the DOE and the state of New Mexico, and evaluation of testing activities related to the Permanent Marker System design. In addition to access control addressed by this report, the controlling or cleaning up of releases from the site is addressed in the Conceptual Decontamination and Decommissioning Plan. The monitoring of parameters related to disposal system performance is addressed in the Long Term Monitoring Design Concept Description. Together, these three documents address the full range of active institutional controls planned after disposal of the TRU waste in the WIPP repository

  7. A critical review of the methodology for assessing farm-level grain losses after harvest (G191)

    OpenAIRE

    Boxall, R.A.

    1986-01-01

    In 1976, the American Association of Cereal Chemists, with a grant from the US Agency for International Development to the League for International Food Education, began to assemble a methodology for assessing post-harvest grain losses. As a result of this initiative, a manual (Post-harvest Grain Loss Assessment Methods, by K. L. Harris and C. J. Lindblad) was published in 1978, detailing the techniques available for the measurement and interpretation of losses which occur after harvest at th...

  8. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 4: Appendix BIR Volume 2

    International Nuclear Information System (INIS)

    This report consists of the waste stream profile for the WIPP transuranic waste baseline inventory at Lawrence Livermore National Laboratory. The following assumptions/modifications were made by the WTWBIR team in developing the LL waste stream profiles: since only current volumes were provided by LL, the final form volumes were assumed to be the same as the current volumes; the WTWBIR team had to assign identification numbers (IDs) to those LL waste streams not given an identifier by the site, the assigned identification numbers are consistent with the site reported numbers; LL Final Waste Form Groups were modified to be consistent with the nomenclature used in the WTWBID, these changes included word and spelling changes, the assigned Final Waste Form Groups are consistent with the information provided by LL; the volumes for the year 1993 were changed from an annual rate of generation (m3/year) to a cumulative value (m3)

  9. Annick Tillier, Marie Vaillant, Histoire tragique d’une infanticide en Bretagne, Paris, Larousse, 2011, 191 p.

    OpenAIRE

    Lambert, Karine

    2013-01-01

    Annick Tillier, docteur en histoire et conservateur en chef à la Bibliothèque nationale de France, a étudié à l’occasion de sa thèse publiée en 2001 aux Presses Universitaires de Rennes sous le titre Des criminelles au village : femmes infanticides en Bretagne, 1825-1865 plus de 600 procédures judicaires pour meurtres de nouveau-nés jugés par les cours d'assises des cinq départements bretons. De cette masse archivistique, elle a exhumé Marie Vaillant dont elle reconstitue le parcours de vie t...

  10. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 2: Appendices, AAC, BECR, BH

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    This report describes the conceptual design of a system the Department of Energy (DOE) may implement for compliance with the requirement to control access to the disposal site. In addition, this report addresses the scheduling process for control of inspection, maintenance, and periodic reporting related to Long Term Monitoring which addresses the monitoring of disposal system performance, environmental monitoring in accordance with the Consultation and Cooperation Agreement between the DOE and the state of New Mexico, and evaluation of testing activities related to the Permanent Marker System design. In addition to access control addressed by this report, the controlling or cleaning up of releases from the site is addressed in the Conceptual Decontamination and Decommissioning Plan. The monitoring of parameters related to disposal system performance is addressed in the Long Term Monitoring Design Concept Description. Together, these three documents address the full range of active institutional controls planned after disposal of the TRU waste in the WIPP repository.

  11. Shelf-Life of ɛ-Lysyl-3-(Trimethylstannyl)Benzamide Immunoconjugates, Precursors for 211At Labeling of Antibodies

    OpenAIRE

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per; Jensen, Holger; Holgersson, Stellan; Lindegren, Sture

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity and the complex radiochemistry of 211At are major obstacles for research and prospective clinical applications. In the present study, astatination of immunoconjugates, already prepared well in advance...

  12. Decree of the Czechoslovak Atomic Energy Commission No. 191/1989 on procedures, terms and conditions for examining special professional qualification and competence of selected nuclear facility personnel

    International Nuclear Information System (INIS)

    The procedures, terms and conditions for examining special professional competence of selected nuclear facility personnel are specified, including conditions for professional training and for issuing licenses qualifying the personnel for their work. Nuclear safety-related jobs at nuclear facilities are listed. Professional licenses with a two-year term of validity are granted by the Czechoslovak Atomic Energy Agency (CSAEC) to candidates who have passed examination before the State Examination Commission. Personnel training may only be performed by bodies authorized for that by the CSAEC. The Decree entered into force on 1 January 1990. (J.B.)

  13. Preliminary comparison with 40 CFR Part 191, Subpart B for the Waste Isolation Pilot Plant, December 1991. Vol. 4: Uncertainty and sensitivity analysis results

    International Nuclear Information System (INIS)

    The most appropriate conceptual model for performance assessment at the Waste Isolation Pilot Plant (WIPP) is believed to include gas generation due to corrosion and microbial action in the repository and a dual-porosity (matrix and fracture porosity) representation for solute transport in the Culebra Dolomite Member of the Rustler Formation. Under these assumptions, complementary cumulative distribution functions (CCDFs) summarizing radionuclide releases to the accessible environment due to both cuttings removal and groundwater transport fall substantially below the release limits promulgated by the Environmental Protection Agency (EPA). This is the case even when the current estimates of the uncertainty in analysis inputs are incorporated into the performance assessment. The best-estimate performance-assessment results are dominated by cuttings removal. The releases to the accessible environment due to groundwater transport make very small contributions to the total release. The variability in the distribution of CCDFs that must be considered in comparisons with the EPA release limits is dominated by the variable LAMBDA (rate constant in Poisson model for drilling intrusions). The variability in releases to the accessible environment due to individual drilling intrusions is dominated by DBDIAM (drill bit diameter). Most of the imprecisely known variables considered in the 1991 WIPP performance assessment relate to radionuclide releases to the accessible environment due to groundwater transport. For a single borehole (i.e., an E2-type scenario), whether or not a release from the repository to the Culebra even occurs is controlled by the variable SALPERM (Salado permeability), with no releases for small values (i.e., -21 m2) of this variable. When SALPERM is small, the repository never fills with brine and so there is no flow up an intruding borehole that can transport radionuclides to the Culebra. Further, releases that do reach the Culebra for larger values of SALPERM are small and usually do not reach the accessible environment. A potentially important scenario for the WIPP involves two or more boreholes through the same waste panel, of which at least one penetrates a pressurized brine pocket and at least one does not (i.e., an ElE2-type scenario). For these scenarios, the uncertainty in release to the Culebra is dominated by the variables BHPERM (borehole permeability), BPPRES (brine pocket pressure), and the solubilities for the individual elements (i.e., Am, Np, Pu, Th, U) in the projected radionuclide inventory for the WIPP. Once a release reaches the Culebra, the matrix distribution coefficients for the individual elements are important, with releases to the Culebra often failing to reach the accessible environment over the 10,000-yr period specified in the EPA regulations. To provide additional perspective, the following variants of the 1991 WIPP performance assessment have also been considered: (1) no gas generation in the repository and a dual-porosity transport model in the Culebra; (2) gas generation in the repository and a single-porosity (fracture porosity) transport model in the Culebra; (3) no gas generation in the repository and a single-porosity transport model in the Culebra; (4) gas generation in the repository and a dual-porosity transport model in the Culebra without chemical retardation; and (5) gas generation in the repository, a dual-porosity transport model in the Culebra, and extremes of climatic variation. All of these variations relate to groundwater transport and thus do not affect releases due to cuttings removal, which were found to dominate the results of the 1991 WIPP performance assessment. However, these variations do have the potential to increase the importance of releases due to groundwater transport relative to releases due to cuttings removal. (author)

  14. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 5: Appendices D and D, DEF, FAC

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    This plan serves to describe the objectives of decommissioning for the Waste Isolation Pilot Plant (WIPP), identifies the elements necessary to accomplish the decommissioning, and defines the steps to execute those elements in a safe and environmentally sound manner. The plan provides a strategy for progressing from the final actions of the Disposal Phase, through the Decontamination and Decommissioning Phase, and into the initiation of the Long-Term Monitoring Phase. This plan describes a sequence of events for decontamination of the WIPP facilities and structures used to manage and contain TRU and TRU mixed waste during the receipt and emplacement operations. Alternative methods of decontamination are provided where practical. The methods for packaging and disposal of the waste generated (derived waste) during this process are discussed. The best available technology at the time of this plan`s development, may become outmoded by future technology and alternative strategies. If alternative technologies are identified the affected stakeholder(s), the Secretary of the Interior and the State will be consulted prior to implementation.

  15. Odd and even partial waves of eta pi(-) and eta 'pi(-) in pi(-) p -> eta(('))pi(-)p at 191 GeV/c

    Czech Academy of Sciences Publication Activity Database

    Adolph, C.; Akhunzyanov, R.; Alexeev, M. G.; Alexeev, G. D.; Amoroso, A.; Andrieux, V.; Anosov, V.; Austregesilo, A.; Badelek, B.; Balestra, F.; Barth, J.; Baum, G.; Beck, R.; Bedfer, Y.; Berlin, A.; Bernhard, J.; Bicker, K.; Bielert, E. R.; Bieling, J.; Birsa, R.; Bisplinghoff, J.; Bodlak, M.; Boer, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bressan, A.; Büchele, M.; Burtin, E.; Capozza, L.; Chiosso, M.; Chung, S. U.; Cicuttin, A.; Crespo, M.; Curiel, Q.; Dalla Torre, S.; Dasgupta, S. S.; Dasgupta, S.; Denisov, O. Yu.; Donskov, S. V.; Doshita, N.; Duic, V.; Dünnweber, W.; Dziewiecki, M.; Efremov, A.; Elia, C.; Eversheim, P.D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Finger jr., M.; Fischer, A.; Franco, C.; Fresne von Hohenesche, N.; Friedrich, J. M.; Frolov, V.; Gautheron, F.; Gavrichtchouk, O. P.; Gerassimov, S.; Geyer, R.; Gnesi, I.; Gobbo, B.; Goertz, S.; Gorzellik, M.; Grabmüller, S.; Grasso, A.; Grube, B.; Grussenmeyer, T.; Guskov, A.; Haas, F.; von Harrach, D.; Hahne, D.; Hashimoto, R.; Heinsius, F. H.; Herrmann, F.; Hinterberger, F.; Höppner, Ch.; Horikawa, N.; d´Hose, N.; Huber, S.; Ishimoto, S.; Ivanov, A.; Ivanshin, Yu.; Iwata, T.; Jahn, R.; Jary, V.; Jasinski, P.; Jörg, P.; Joosten, R.; Kabuss, E.; Ketzer, B.; Khaustov, G. V.; Khokhlov, Yu. A.; Kisselev, Y.; Klein, F.; Klimaszewski, A. D.; Koivuniemi, J. H.; Kolosov, V. N.; Kondo, K.; Königsmann, K.; Konorov, I.; Konstantinov, V. F.; Kotzinian, A. M.; Kouznetsov, O.; Krämer, M.; Kroumchtein, Z. V.; Kuchinski, N.; Kunne, F.; Kurek, K.; Kurjata, R. P.; Lednev, A. A.; Lehmann, A.; Levillain, M.; Levorato, S.; Lichtenstadt, J.; Maggiora, A.; Magnon, A.; Makke, N.; Mallot, G. K.; Marchand, C.; Martin, A.; Marzec, J.; Matoušek, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G.; Meyer, W.; Michigami, T.; Mikhailov, Yu. V.; Miyachi, Y.; Nagaytsev, A.; Nagel, T.; Nerling, F.; Neubert, S.; Neyret, D.; Nový, J.; Nowak, W. D.; Nunes, A.S.; Olshevsky, A. G.; Orlov, I.; Ostrick, M.; Panknin, R.; Panzieri, D.; Parsamyan, B.; Paul, S.; Peshekhonov, D. V.; Platchkov, S.; Pochodzalla, J.; Polyakov, V.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Regali, C.; Reicherz, G.; Rocco, E.; Rossiyskaya, N. S.; Ryabchikov, D.; Rychter, A.; Samoylenko, V. D.; Sandacz, A.; Sarkar, S.; Savin, I. A.; Sbrizzai, G.; Schiavon, P.; Schill, C.; Schlüter, T.; Schmidt, K.; Schmieden, H.; Schönning, K.; Schopferer, S.; Schott, M.; Shevchenko, O. Yu.; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Sosio, S.; Sozzi, F.; Srnka, Aleš; Steiger, L.; Stolarski, M.; Sulc, M.; Sulej, R.; Suzuki, H.; Szabelski, A.; Szameitat, T.; Sznajder, P.; Takekawa, S.; Ter Wolbeek, J.; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Uhl, S.; Uman, I.; Virius, M.; Wang, L.; Weisrock, T.; Wilfert, M.; Windmolders, R.; Wollny, H.; Zaremba, K.; Zavertyaev, M.; Zemlyanichkina, E.; Ziembicki, M.; Zink, A.

    2015-01-01

    Roč. 740, 5 JAN (2015), s. 303-311. ISSN 0370-2693 R&D Projects: GA MŠk(CZ) LO1212 Institutional support: RVO:68081731 Keywords : eta-pi * annihilation * resonance * systems * state * rest Subject RIV: BH - Optics, Masers, Lasers Impact factor: 6.131, year: 2014

  16. The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice

    OpenAIRE

    Reichmann, Judith; Reddington, James P.; Best, Diana; Read, David; Ollinger, Rupert; Meehan, Richard R.; Adams, Ian R.

    2013-01-01

    DNA methylation plays an important role in suppressing retrotransposon activity in mammalian genomes, yet there are stages of mammalian development where global hypomethylation puts the genome at risk of retrotransposition-mediated genetic instability. Hypomethylated primordial germ cells appear to limit this risk by expressing a cohort of retrotransposon-suppressing genome-defence genes whose silencing depends on promoter DNA methylation. Here, we investigate whether similar mechanisms opera...

  17. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 5: Appendices D and D, DEF, FAC

    International Nuclear Information System (INIS)

    This plan serves to describe the objectives of decommissioning for the Waste Isolation Pilot Plant (WIPP), identifies the elements necessary to accomplish the decommissioning, and defines the steps to execute those elements in a safe and environmentally sound manner. The plan provides a strategy for progressing from the final actions of the Disposal Phase, through the Decontamination and Decommissioning Phase, and into the initiation of the Long-Term Monitoring Phase. This plan describes a sequence of events for decontamination of the WIPP facilities and structures used to manage and contain TRU and TRU mixed waste during the receipt and emplacement operations. Alternative methods of decontamination are provided where practical. The methods for packaging and disposal of the waste generated (derived waste) during this process are discussed. The best available technology at the time of this plan's development, may become outmoded by future technology and alternative strategies. If alternative technologies are identified the affected stakeholder(s), the Secretary of the Interior and the State will be consulted prior to implementation

  18. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 8: Appendices HYDRO, IRD, LTM, NUTS, PAR, PMR, QAPD, RBP

    International Nuclear Information System (INIS)

    Geohydrologic data have been collected in the Los Medanos area at the US Department of Energy's proposed Waste Isolation Pilot Plant (WIPP) site in southeastern New Mexico since 1975 as part of a study evaluating the feasibility of storing defense-associated nuclear wastes within the bedded salt of the Salado Formation of Permian age. Drilling and hydrologic testing have identified three principal water-bearing zones above the Salado Formation and one below that could potentially transport wastes to the biosphere if the proposed facility were breached. The zones above the Salado are the contact between the Rustler and Salado Formations and the Culebra and Magenta Dolomite Members of the Rustler Formation of Permian age. The zone below the Salado Formation consists of channel sandstones in the Bell Canyon Formation of the Permian Delaware Mountain Group. Determinations of hydraulic gradients, directions of flow, and hydraulic properties were hindered because of the negligible permeability of the water-bearing zones. Special techniques in drilling, well completion, and hydraulic testing have been developed to determine the hydrologic characteristics of these water-producing zones

  19. Rapid needle-out patient-rollover approach after cone beam CT-guided lung biopsy: effect on pneumothorax rate in 1,191 consecutive patients

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jung Im [Seoul National University College of Medicine, Department of Radiology, Jongno-gu, Seoul (Korea, Republic of); Seoul National University Medical Research Center, Institute of Radiation Medicine, Seoul (Korea, Republic of); Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Department of Radiology, Seoul (Korea, Republic of); Park, Chang Min; Goo, Jin Mo [Seoul National University College of Medicine, Department of Radiology, Jongno-gu, Seoul (Korea, Republic of); Seoul National University, Cancer Research Institute, Seoul (Korea, Republic of); Lee, Sang Min [Seoul National University College of Medicine, Department of Radiology, Jongno-gu, Seoul (Korea, Republic of)

    2015-07-15

    To investigate the effect of rapid needle-out patient-rollover approach on the incidence of pneumothorax and drainage catheter placement due to pneumothorax in C-arm Cone-beam CT (CBCT)-guided percutaneous transthoracic needle biopsy (PTNB) of lung lesions. From May 2011 to December 2012, 1227 PTNBs were performed in 1191 patients with a 17-gauge coaxial needle. 617 biopsies were performed without (conventional-group) and 610 with rapid-rollover approach (rapid-rollover-group). Overall pneumothorax rates and incidences of pneumothorax requiring drainage catheter placement were compared between two groups. There were no significant differences in overall pneumothorax rates between conventional and rapid-rollover groups (19.8 % vs. 23.1 %, p = 0.164). However, pneumothorax rate requiring drainage catheter placement was significantly lower in rapid-rollover-group (1.6 %) than conventional-group (4.2 %) (p = 0.010). Multivariate analysis revealed male, age > 60, bulla crossed, fissure crossed, pleura to target distance > 1.3 cm, emphysema along needle tract, and pleural punctures ≥ 2 were significant risk factors of pneumothorax (p < 0.05). Regarding pneumothorax requiring drainage catheter placement, fissure crossed, bulla crossed, and emphysema along needle tract were significant risk factors (p < 0.05), whereas rapid-rollover approach was an independent protective factor (p = 0.002). The rapid needle-out patient-rollover approach significantly reduced the rate of pneumothorax requiring drainage catheter placement after CBCT-guided PTNB. (orig.)

  20. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 9: Appendices RM, SCR, SER, SUM, WRAC

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    The Rock Mechanics Program is important to the establishment of a radioactive waste repository in salt because rock mechanics deals with the prediction of creep closure and eventual encapsulation of the waste. The intent of this paper is to give the current status of the program. This program consists of three major modeling efforts: continuum creep, fracture, and the disturbed rock zone. These models, together with laboratory material parameters, plastic flow potentials, initial and boundary input data, and other peripheral information forms the predictive technology. The extent to which the predictive technology is validated against in situ test data adds certainty to the method. Application of the technology is through simulations of the test results, design, or performance using numerical codes. In summary, the predictive capabilities are technically sound and reasonable. The current status of the program is that which would be advanced for compliance.

  1. 75 FR 24504 - Proposed Modification of VOR Federal Airways V-82, V-175, V-191, and V-430 in the Vicinity of...

    Science.gov (United States)

    2010-05-05

    ... Department of Transportation (DOT) Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and..., 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 2. The incorporation by... TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 RIN 2120-AA66 Proposed Modification of VOR...

  2. Health care programs: fraud and abuse; revised OIG civil money penalties resulting from public law 104-191. Office of Inspector General (OIG), HHS. Final rule.

    Science.gov (United States)

    2000-04-26

    This final rule revises the OIG's civil money penalty (CMP) authorities, in conjunction with new and revised provisions set forth in the Health Insurance Portability and Accountability Act of 1996. Among other provisions, this final rulemaking codifies new CMPs for excluded individuals retaining ownership or control interest in an entity; upcoding and claims for medically unnecessary services; offering inducements to beneficiaries; and false certification of eligibility for home health services. This rule also codifies a number of technical corrections to the regulations governing OIG's sanction authorities. PMID:11010671

  3. Rapid needle-out patient-rollover approach after cone beam CT-guided lung biopsy: effect on pneumothorax rate in 1,191 consecutive patients

    International Nuclear Information System (INIS)

    To investigate the effect of rapid needle-out patient-rollover approach on the incidence of pneumothorax and drainage catheter placement due to pneumothorax in C-arm Cone-beam CT (CBCT)-guided percutaneous transthoracic needle biopsy (PTNB) of lung lesions. From May 2011 to December 2012, 1227 PTNBs were performed in 1191 patients with a 17-gauge coaxial needle. 617 biopsies were performed without (conventional-group) and 610 with rapid-rollover approach (rapid-rollover-group). Overall pneumothorax rates and incidences of pneumothorax requiring drainage catheter placement were compared between two groups. There were no significant differences in overall pneumothorax rates between conventional and rapid-rollover groups (19.8 % vs. 23.1 %, p = 0.164). However, pneumothorax rate requiring drainage catheter placement was significantly lower in rapid-rollover-group (1.6 %) than conventional-group (4.2 %) (p = 0.010). Multivariate analysis revealed male, age > 60, bulla crossed, fissure crossed, pleura to target distance > 1.3 cm, emphysema along needle tract, and pleural punctures ≥ 2 were significant risk factors of pneumothorax (p < 0.05). Regarding pneumothorax requiring drainage catheter placement, fissure crossed, bulla crossed, and emphysema along needle tract were significant risk factors (p < 0.05), whereas rapid-rollover approach was an independent protective factor (p = 0.002). The rapid needle-out patient-rollover approach significantly reduced the rate of pneumothorax requiring drainage catheter placement after CBCT-guided PTNB. (orig.)

  4. « A Bactrian Deed of Manumission ». Silk Road Art and Archaeology, 5, (1997-8), pp. 191-212

    OpenAIRE

    La Vaissière, Étienne de

    2010-01-01

    L’A. présente un contrat bactrien de libération d’esclave, désormais conservé au Japon, mais provenant sans doute du Tokharestan (il est rédigé dans la cité de Lan que les sources chinoises situent dans cette région). Il date probablement de 479. L’A. en donne une édition, une traduction, un commentaire philologique et historique, des photos, ainsi qu’un glossaire. Parmi les points les plus intéressants historiquement, mentionnons l’existence d’un βαγοβανδαγο bactrien, ce qui peut conduire à ...

  5. Identification of a New Marine Steroid-degrading Bacterium S19-1 and Isolation of Estradiol-inducible Genes and a Novel Promoter from this Bacterium

    OpenAIRE

    Zhang, Tingdi

    2012-01-01

    Summary Environmental estrogens in water have been reported to be associated with abnormal sexual development and abnormal feminizing responses in some animals. Estrogen contamination of sea water is an ever growing problem and impacts population dynamics of all kinds of sea animals. Researches about elimination of estrogens from the contaminated environment have become a major issue in environmental research and policy. It has been demonstrated that biological processes play an important...

  6. Development of Optical Fiber Technology in Poland, International Journal of Electronics and Telecommunication, vol. 57, no 2, pp.191-197, July 2011

    CERN Document Server

    Dorosz, J

    2011-01-01

    In this paper, the authors, chairmen of the 13th Conference on Optical Fibers and Their Applications OFA2011, and editors of the conference proceedings summarize the development of optical fiber technology in Poland (during the period of 2009- 2011) on the basis of papers presented there and consecutively published in this volume. The digest is thus not full but covers the periodically presented material every 18 months during the meetings on optical fibers in Białystok-Białowie˙za and Lublin- Krasnobród. OFC systems are developed for HEP experiments and accelerators. OFC systems are also developed for virtual atomic clocks. EuCARD information presentation was organized during this meeting. Keywords— optical fibers, optical communication systems, photonic sources and detectors, photonic sensors, integrated optics, photonics applications, photonic materials.

  7. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 9: Appendices RM, SCR, SER, SUM, WRAC

    International Nuclear Information System (INIS)

    The Rock Mechanics Program is important to the establishment of a radioactive waste repository in salt because rock mechanics deals with the prediction of creep closure and eventual encapsulation of the waste. The intent of this paper is to give the current status of the program. This program consists of three major modeling efforts: continuum creep, fracture, and the disturbed rock zone. These models, together with laboratory material parameters, plastic flow potentials, initial and boundary input data, and other peripheral information forms the predictive technology. The extent to which the predictive technology is validated against in situ test data adds certainty to the method. Application of the technology is through simulations of the test results, design, or performance using numerical codes. In summary, the predictive capabilities are technically sound and reasonable. The current status of the program is that which would be advanced for compliance

  8. blaCTX-M-1/9/1 Hybrid Genes May Have Been Generated from blaCTX-M-15 on an IncI2 Plasmid

    OpenAIRE

    Liu, Lanping; He, Dandan; Lv, Luchao; Liu, Wuling; Chen, Xiaojie; Zeng, Zhenling; Partridge, Sally R.; Liu, Jian-Hua

    2015-01-01

    Three hybrid CTX-M β-lactamases, CTX-M-64, CTX-M-123, and CTX-M-132, with N and C termini matching CTX-M-1 group enzymes and centers matching CTX-M-9 group enzymes, have been identified. The hybrid gene sequences suggested recombination between blaCTX-M-15 and blaCTX-M-14, the two most common blaCTX-M variants worldwide. However, blaCTX-M-64 and blaCTX-M-123 are found in an ISEcp1-blaCTX-M transposition unit with a 45-bp “spacer,” rather than the 48 bp usually associated with blaCTX-M-15, and...

  9. The Oral Background of Persian Epics. Storytelling and Poetry. Leiden-Boston, Brill, 2003, Studies in Middle Eastern Literatures, vol. XXVI, 191 p., bibl., index.

    OpenAIRE

    Gaillard, Marina

    2005-01-01

    C’est avec un souci de méthodologie très appréciable que l’A. aborde la question difficile de l’influence de l’oralité sur la genèse et l’évolution de la tradition persane épique. Prenant pour point de départ l’Oral-Formulaic Theory (voir les travaux d’A. B. Lord et d’A. Parry et les récentes études d’O. M. Davidson), elle en propose une approche alternative, définissant un Oral Performance Model composé d’un ensemble de critères formels et thématiques. Ce modèle est élaboré à partir de l’étu...

  10. Draft Title 40 CFR 191 compliance certification application for the Waste Isolation Pilot Plant. Volume 8: Appendices HYDRO, IRD, LTM, NUTS, PAR, PMR, QAPD, RBP

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-31

    Geohydrologic data have been collected in the Los Medanos area at the US Department of Energy`s proposed Waste Isolation Pilot Plant (WIPP) site in southeastern New Mexico since 1975 as part of a study evaluating the feasibility of storing defense-associated nuclear wastes within the bedded salt of the Salado Formation of Permian age. Drilling and hydrologic testing have identified three principal water-bearing zones above the Salado Formation and one below that could potentially transport wastes to the biosphere if the proposed facility were breached. The zones above the Salado are the contact between the Rustler and Salado Formations and the Culebra and Magenta Dolomite Members of the Rustler Formation of Permian age. The zone below the Salado Formation consists of channel sandstones in the Bell Canyon Formation of the Permian Delaware Mountain Group. Determinations of hydraulic gradients, directions of flow, and hydraulic properties were hindered because of the negligible permeability of the water-bearing zones. Special techniques in drilling, well completion, and hydraulic testing have been developed to determine the hydrologic characteristics of these water-producing zones.

  11. Dicty_cDB: Contig-U14105-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available rxirnfkqqvdsgvisldenkwiaigskiftxvsetikalxdixladlsfrlylqa lqtfdhcglvsrvkelaikallifqediadfxaqvmalqllixtfn*fhhskfhhsklis tcs...tagctttagattataccttcaagcactccaaacct 190 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct...: 131 tgnccgatatcnaattggccgatcttagctttagattataccttcaagcactccaaacct 190 Query: 191 ttgaccactgtggtttggtctctc...gtgtcaaagaattggccatcaaggctctcttaatct 250 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct...: 191 ttgaccactgtggtttggtctctcgtgtcaaagaattggccatcaaggctctcttaatct 250 Query: 251 tc

  12. Shelf-life of ɛ-lysyl-3-(trimethylstannyl)benzamide immunoconjugates, precursors for 211At labeling of antibodies

    DEFF Research Database (Denmark)

    Aneheim, Emma; Halleröd, Jenny; Albertsson, Per;

    2015-01-01

    Astatine-211 is possibly the most promising radionuclide for targeted α-particle therapy when it comes to the treatment of occult disseminated cancer. Preclinical research has proven effective, and patient studies have been initiated based on these results. However, a lack of production capacity ...

  13. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    Energy Technology Data Exchange (ETDEWEB)

    Jaszczak, R.J.

    1995-12-01

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons.

  14. SPECT assay of radiolabeled monoclonal antibodies. Final performance report, March 1992--November 1995

    International Nuclear Information System (INIS)

    Research is described in the following areas: development and evaluation quantitatively of reconstruction algorithms with improved compensations for attenuation, scatter, and geometric collimator response; evaluation of single photon emission computed tomography (SPECT) quantification of iodine 123 and astatine 211; and the development and evaluation of SPECT pinhole imaging for low and medium energy photons

  15. Separation of 211At from irradiated bismuth target and labelling of a model protein

    International Nuclear Information System (INIS)

    Astatine-211 is a promising radionuclide for therapeutic use in nuclear medicine. An efficient method (70%) for radiochemical separation from the irradiated Bi-target has been described. The level of Bi contamination in the purified 2'11At-solution was estimated. Finally labelling of a model protein has been tried. (author). 14 refs

  16. P191-M A Comparison of nLC-ESI-MS/MS and nLC-MALDI-MS/MS for GeLC-Based Protein Identification and iTRAQ-Based Shotgun Quantitative Proteomics

    OpenAIRE

    Yang, Y.; S. Zhang; Howe, K; Thannhauser, T W

    2007-01-01

    The use of nano-HPLC electrospray ionization multistage tandem mass spectrometry (nLC-ESI-MS/MS) in shotgun proteomics experiments and nano-liquid-chromatography tandem mass spectrometry (GeLC-MS/MS) analysis is well accepted and routinely available in most proteomics laboratories. The same can not be said for nLC-MALDI MS/MS, which has yet to experience such widespread acceptance. This is not totally surprising, given the inability to monitor the separation performance in real time and the t...

  17. Physical trajectory profile data from glider unit_191 deployed by University of Alaska - Fairbanks in the Southern Oceans from 2015-01-05 to 2015-02-26 (NCEI Accession 0145717)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this glider mission is to do along canyon transects of Palmer Deep within the operating CODAR fields off of Anvers Island. This multi-platform field...

  18. A summary of the models used for the mechanical response of disposal rooms in the Waste Isolation Pilot Plant with regard to compliance with 40 CFR 191, Subpart B

    International Nuclear Information System (INIS)

    A summary is presented of the results of a number of studies conducted prior to March 1992 that have led to a conceptual model describing how the porosity (and therefore the permeability) of waste and backfill in a Waste Isolation Pilot Plant disposal room changes with time and also describes how results from calculations involving mathematical models of these processes are used to provide input into performance assessment of the repository. Included in the report are descriptions of essential material response or constitutive models that include the influence of gas generation and the response of simple gas-pressurized cracks and fractures in salt, marker beds, and clay seams. Two-dimensional versus three-dimensional disposal room configurations and descriptions of the differences between numerical codes are also discussed. Calculational results using the mathematical models for disposal room response are described, beginning with closure of empty rooms and becoming progressively more complex. More recent results address some of the effects of gas generation in a room containing waste and backfill and intersected by a gas permeable marker bed. Developments currently in progress to improve the evaluation of the disposal room performance are addressing the coupling between brine flow and closure and the two-dimensional capability for analyzing a complete panel of rooms. Next, a method is described for including disposal room closure results into performance assessment analyses that determine if the repository is in compliance with regulatory standards. The coupling is accomplished using closure surfaces that describe the relationship among porosity, total amount of gas in the repository, and time. A number of conclusions about room response and recommendations for further work are included throughout the report

  19. Enhanced 1-m Composite Grayscale GeoTIFF Image of the Sidescan-Sonar Data From NOAA Survey H11076 of the Sea Floor in Quicks Hole, MA (H11076_UTM19_1MRSSS.TIF, UTM Zone 19)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The U.S. Geological Survey (USGS), in cooperation with the National Oceanic and Atmospheric Administration (NOAA) and the Massachusetts Office of Coastal Zone...

  20. CORRIGENDUM to J Exp Integr Med 2013; 3(3: 191-197 - ETB receptor activation as a mechanism of modulation of inflammatory pain and neurogenic inflammation in the temporomandibular joint of capsaicin-treated rats

    Directory of Open Access Journals (Sweden)

    Thiago E. V. Lemos

    2014-02-01

    Full Text Available The Publisher and the Editorial Board regrets to declare an obligatory modification in the author list of the above manuscript originally published in the July 2013 issue (Volume 3, Issue 3 of the Journal. Three months after publication in both print and online forms, the author in the third order of the first published version contacted the Editorial Board and declared that he did not participate to this work and requested his name to be removed from the author list. During submission, the Journal of Experimental and Integrative Medicine requests a clear statement that all authors are aware of the work, as was done for this particular article; thus, neither the Publisher nor the editors are responsible for this unwanted condition. This one-page publication corrects and updates the author list for the above-mentioned paper. The same correction was also done in the web page of the Journal (www.jeim.org/?mno=34844, however, the PDF-document remained unchanged as the same in the print version of the Journal. [J Exp Integr Med 2014; 4(1.000: 74-74

  1. Catherine Halpern, Michèle Bitton, Lilith, l’épouse de Satan, Paris, Larousse, coll. « Dieux, Mythes et Héros », 2010, 191 p.

    OpenAIRE

    Guillaume Roucoux

    2011-01-01

    Lilith, l’épouse de Satan est la quatrième figure féminine à s’inscrire dans la collection de « Dieux, Mythes & Héros » qui ne cache pas « le caractère profondément masculin de la mythologique en général » (p. 167), pour mieux lui résister. Ce portrait en six chapitres, dressé par la journaliste Catherine Halpern et la sociologue Michèle Bitton à partir de textes théologiques judéo-chrétiens et d’analyses scientifiques, nous donne à voir une Lilith plurielle mais dont « la plus grande par...

  2. Catherine Halpern, Michèle Bitton, Lilith, l’épouse de Satan, Paris, Larousse, coll. « Dieux, Mythes et Héros », 2010, 191 p.

    Directory of Open Access Journals (Sweden)

    Guillaume Roucoux

    2011-10-01

    Full Text Available Lilith, l’épouse de Satan est la quatrième figure féminine à s’inscrire dans la collection de « Dieux, Mythes & Héros » qui ne cache pas « le caractère profondément masculin de la mythologique en général » (p. 167, pour mieux lui résister. Ce portrait en six chapitres, dressé par la journaliste Catherine Halpern et la sociologue Michèle Bitton à partir de textes théologiques judéo-chrétiens et d’analyses scientifiques, nous donne à voir une Lilith plurielle mais dont « la plus grande partie ...

  3. Estudo comparativo do desenvolvimento sensório-motor de recém-nascidos prematuros da unidade de terapia intensiva neonatal e do método canguru - doi:10.5020/18061230.2005.p191

    OpenAIRE

    Luciana Andrade da Mota; Fabiane Elpídio de Sá; Mirna Albuquerque Frota

    2012-01-01

    O Método Canguru é uma alternativa ao método tradicional de assistência a bebês prematuros de baixo peso, que preconiza o contato pele a pele precoce, entre mãe e filho, 24 horas por dia, garantindo-lhes estímulos sensoriais e motores e maior participação dos pais no cuidado de seu bebê. A Unidade de Terapia Intensiva (UTI) Neonatal é destinada ao tratamento de recém-nascidos prematuros com algum problema ao nascer. Objetivou-se comparar o desenvolvimento sensório-motor de recém-nascidos prem...

  4. Estudo comparativo do desenvolvimento sensório-motor de recém-nascidos prematuros da unidade de terapia intensiva neonatal e do método canguru - doi:10.5020/18061230.2005.p191

    Directory of Open Access Journals (Sweden)

    Luciana Andrade da Mota

    2012-01-01

    Full Text Available O Método Canguru é uma alternativa ao método tradicional de assistência a bebês prematuros de baixo peso, que preconiza o contato pele a pele precoce, entre mãe e filho, 24 horas por dia, garantindo-lhes estímulos sensoriais e motores e maior participação dos pais no cuidado de seu bebê. A Unidade de Terapia Intensiva (UTI Neonatal é destinada ao tratamento de recém-nascidos prematuros com algum problema ao nascer. Objetivou-se comparar o desenvolvimento sensório-motor de recém-nascidos prematuros (RNPt da UTI Neonatal e do Método Canguru. Realizou-se um estudo comparativo, prospectivo e observacional, no Hospital Geral Dr. César Cals, em Fortaleza – CE, de agosto a outubro de 2004, com 14 RNPt, sendo 07 de cada grupo, com peso inferior a 2000g e idade gestacional entre 30 e 37 semanas. A avaliação foi semanal até a alta hospitalar ou até completarem a idade corrigida de 40 semanas, pelo método Dubowitz e Amiel-Tison, com análise de tônus muscular, respostas sensório-motoras, ganho de peso e tempo de internação. Como resultado, observou-se que os bebês do Método Canguru apresentaram melhores respostas sensório-motoras, comprovadas a partir da constatação de um menor grau de estresse, melhores respostas reflexas, movimentação espontânea e tônus muscular, e menor tempo de internação, permanecendo mais tempo em estado de alerta e interagindo bem com o ambiente e a mãe. Conclui-se que o Método Canguru mostrou-se uma alternativa mais eficaz de assistência a RNPt de baixo peso, pois proporcionou melhores resultados quanto às atividades sensório-motor dos bebês, se comparados à UTI Neonatal.

  5. Alain Caillé, Marc Humbert, Serge Latouche et Patrick Viveret, 2011, de la convivialité. Dialogues sur la société conviviale à venir, Paris : La Découverte, 191 p.

    OpenAIRE

    Igor Martinache

    2011-01-01

    Souvent, les ouvrages collectifs se limitent à la juxtaposition de contributions où chaque auteur expose ses propres recherches sans réellement dialoguer avec ses voisins. Au lecteur d'établir les ponts qui se logent fréquemment dans les subtilités d'un jargon dont l'accessibilité est inversement proportionnelle à la volonté de paraître « scientifique ». Ou, pire encore, les désaccords entre les co-auteurs y sont pudiquement cachés sous le tapis pour laisser place à une espèce de consensus au...

  6. A summary of the models used for the mechanical response of disposal rooms in the Waste Isolation Pilot Plant with regard to compliance with 40 CFR 191, Subpart B

    Energy Technology Data Exchange (ETDEWEB)

    Butcher, B.M.; Mendenhall, F.T.

    1993-08-01

    A summary is presented of the results of a number of studies conducted prior to March 1992 that have led to a conceptual model describing how the porosity (and therefore the permeability) of waste and backfill in a Waste Isolation Pilot Plant disposal room changes with time and also describes how results from calculations involving mathematical models of these processes are used to provide input into performance assessment of the repository. Included in the report are descriptions of essential material response or constitutive models that include the influence of gas generation and the response of simple gas-pressurized cracks and fractures in salt, marker beds, and clay seams. Two-dimensional versus three-dimensional disposal room configurations and descriptions of the differences between numerical codes are also discussed. Calculational results using the mathematical models for disposal room response are described, beginning with closure of empty rooms and becoming progressively more complex. More recent results address some of the effects of gas generation in a room containing waste and backfill and intersected by a gas permeable marker bed. Developments currently in progress to improve the evaluation of the disposal room performance are addressing the coupling between brine flow and closure and the two-dimensional capability for analyzing a complete panel of rooms. Next, a method is described for including disposal room closure results into performance assessment analyses that determine if the repository is in compliance with regulatory standards. The coupling is accomplished using closure surfaces that describe the relationship among porosity, total amount of gas in the repository, and time. A number of conclusions about room response and recommendations for further work are included throughout the report.

  7. Hurdles for a Broader Use of 211At and for the Synthesis of 211At-Labelled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    One of the key impediments to the use of 211At is the very well known deleterious effect of high radiation fields caused by its alpha particles on the synthesis of 211At-labelled radiopharmaceuticals. This is problematic because radiolysis-mediated effects can produce diminishing efficiency of electrophilic astatination reactions due to increasing deposition of radiation dose with increasing activities and with the passage of the time. Astatine-211 has chemical properties that permit complex labelling strategies and a longer half-life than 213Bi that makes it more suitable when the targeting molecule does not gain immediate access to the tumour cells. The first clinical evaluation was published in 2001 [2] in patients with brain tumour. Although this study circumvents many of the challenges to entering clinical studies with 211At and many obstacles had to be surmounted before clinical studies could be initiated, several problems were encountered in maintaining efficient labelling with escalating radiation dose of α-particle even with fresh 211At elution [3]. Astatine-211 also has an additional hurdle to overcome before to its clinical application in labelled radiopharmaceuticals related with its production and distribution. Among the potential group of promising α- emitter it is the only one produced by cyclotrons, but due to the scarcity of cyclotrons equipped with 25−30 MeV α-particle beams, it will of necessity be utilized in distant locations from the site of production. It presents a major chemical challenge because the diminishing efficiency of electrophilic astatination reactions with the passage of the time is well known, a problem likely related to the radiolysis produced by the high LET (linear energy transfer) meaning that large amounts of energy are deposited in a highly localized manner. This problem has been most comprehensively investigated to understand and evaluate the role of the radiolysis effects of astatine alpha particles in the synthesis

  8. $\\beta$-delayed fission, laser spectroscopy and shape-coexistence studies with radioactive At beams

    CERN Multimedia

    We propose to study the $\\beta$-delayed fission, laser spectroscopy and radioactive decay of the newly available pure beams of neutron-deficient and neutron-rich astatine (Z=85) isotopes. The fission probability and the fission fragment distribution of the even-even isotopes $^{194,196}$Po following the $\\beta$-decay of the isotopes $^{194,196}$At will be studied with the Windmill setup. In-source laser spectroscopy will be performed on the entire astatine isotopic chain, using a combination of the Windmill setup, ISOLTRAP MR-ToF and ISOLDE Faraday. Radioactive decay data will be acquired at the Windmill setup throughout those studies and contribute to the global understanding of the phenomenon of shape coexistence in the neutron-deficient lead region.

  9. Production cross section of At radionuclides from $^{7}$Li+$^{\\textrm{nat}}$Pb and $^{9}$Be+$^{\\textrm{nat}}$Tl reactions

    CERN Document Server

    Maiti, Moumita

    2011-01-01

    Earlier we reported theoretical studies on the probable production of astatine radionuclides from $^{6,7}$Li and $^{9}$Be-induced reactions on natural lead and thalliun targets, respectively. For the first time, in this report, production of astatine radionuclides has been investigated experimentally with two heavy ion induced reactions: $^{9}$Be+$^{\\textrm{nat}}$Tl and $^{7}$Li+$^{\\textrm{nat}}$Pb. Formation cross sections of the evaporation residues, $^{207,208,209,210}$At, produced in (HI, xn) channel, have been measured by the stacked-foil technique followed by the off-line $\\gamma$-spectrometry at the low incident energies ($<$50 MeV). Measured excitation functions have been explained in terms of compound nuclear reaction mechanism using Weisskopf-Ewing and Hauser-Feshbach model. Absolute cross section values are lower than the respective theoretical predictions.

  10. Radiopharmaceutical Chemistry of Targeted Radiopharmaceutics. Synthesis of 211At-Labeled Radiopharmaceuticals at High Activities for Clinical Use

    International Nuclear Information System (INIS)

    Targeted α-particle radiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor with minimal damage to normal tissue due to a range equivalent to only a few cell diameters. Compared with β-emitters they have significant advantages from a radiobiological perspective. The LET of 211At α-particles is more than 400 times higher than the β-particles emitted by 90Y, in addition the distance between ionizing events is almost the same as that between the two strands of DNA, yielding a high probability of creating non-repairable DNA damage. It gives the ability to kill cancer cells not compromised by hypoxia, dose rate effects or cell cycle position, enhancing their attractiveness for targeted radiotherapy. However, translation of the concept to the clinic has been slow, many obstacles had to be surmounted before clinical studies could be initiated, the first clinical evaluation of a 211At- labeled mAb was made in 2001. This study circumvents many of the challenges to entering clinical studies with 211At. But several problems were encountered in maintaining efficient labeling with escalating radiation dose of alpha-particle likely related to radiolysis. The impact of the radiolysis produced by the α-particle over the labeling chemistry is much higher in comparison with typical β-emitters due to a deposition of energy in the solvent in a highly localized manner two orders of magnitude per unit volume higher than 90Y or 131I. Due to these difficulties a comprehensive basic science study about the radiolytic effects of astatine alpha-particles over the synthesis of 211At-labeled radiopharmaceuticals was carried out. Its main goal was overcoming the problem of the synthesis of 211At-labeled radiopharmaceuticals at the high activities necessaries for therapy and also to extend the shelf life of astatine elutions. Briefly this study held several steps, the first one was to study the role of solvent

  11. Radiohalogenation of biomolecules. An experimental study on radiohalogen preparation, precursor synthesis, radiolabeling and biodistribution

    International Nuclear Information System (INIS)

    Radiohalogens are widely used in nuclear medicine, both as tool for diagnostic in vivo imaging, and in radionuclide therapy. This study deals with the use of radiohalogens; separation, precursor synthesis, labeling and biological behavior. The focus is on 211At and 124I, the former being a candidate for nuclide therapy and the latter potentially useful for diagnostic imaging and Auger-electron based radiotherapy. For astatine the separation, labeling and some biological behavior is described, and for iodine the latter two. Astatine was separated from an irradiated bismuth target by dry distillation. A novel cryotrap was developed for the isolation of astatine and subsequent synthesis of radiolabeled compounds. 5-[211At]astato-2'-deoxyuridine (AUdR) and N-succinimidyl-4-[211At]astatobenzoate (SAB) were synthesized in 95% respectively 90% radiochemical yields. The former is incorporated into DNA of proliferating cells and can therefore be used as an endoradiotherapeutic agent. The latter is a conjugate for the astatination of proteins. Human epidermal growth factor (hEGF) was tagged with astatine using three approaches: a) direct labeling of native hEGF, b) conjugation with SAB, and c) direct labeling of an hEGF - 7-(3-aminopropyl)-7,8-dicarba-nido-undecaborate(1-) conjugate. The overall labeling yields were 3.5% for direct labeling, 44% for SAB and 70% for the hEGF-nido-carborane conjugate. A new route to N-succinimidyl 3- and 4- [124I]iodobenzoate, two reagents for radioiodination of proteins is described affording 90% radiochemical yield. Three radioiodinated analogs of PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxyam ide, a peripheral-type benzodiazepine receptor antagonist, were synthesized. All three analogs were obtained in >90% radiochemical yield. Synthesis and application of 5-[124I]iodo-2'-deoxyuridine (IUdR) is presented. The closo-dodecaborate anion was evaluated as prosthetic group for radioiodination of macromolecules

  12. Immunomodulation of the pro-inflammatory cytokine pattern of coeliac disease mucosa by bifidobacteria

    Czech Academy of Sciences Publication Activity Database

    Sanz, Y.; De Palma, G.; Cinová, Jana; Štěpánková, Renata; Tučková, Ludmila

    Amsterdam : Springer, 2009. s. 191-191. [International Coeliac Disease Symposium 2009 /13./. 06.04.2009-08.04.2009, Amsterdam] Institutional research plan: CEZ:AV0Z50200510 Keywords : celiac disease * probiotic Subject RIV: EC - Immunology

  13. 211At production and recovery: first results of a new start

    International Nuclear Information System (INIS)

    Full text: 211At is the only alpha-emitting isotope which can be introduced into organic molecular structures by covalent chemical binding and possesses superior decay characteristics for therapeutic applications when compared with other alpha emitters. However, its production requires a minimum of 27,5 MeV alpha-particles, which are relatively rarely available. In view of the revival of alpha-therapy approaches a production of 211At has been set up at the MHH cyclotron (MC-35). The first aim of this project was to establish a target- and work-up-system for the reliable production of several ten MBq-quantities of 211At for animal- and cell-research. An aluminum-target-system holds a 1.3 cm diameter Bi-disc of 0.25 mm thickness. The disk is pressed onto a the aluminum backing with 2 tons/cm2. The front is covered with a 125 μm Al foil, cooled by a He jet which is separated from the vacuum by a 250 μm Ti foil. Starting with 27.5 MeV alpha-particles the resulting target-energy is 25 MeV. This relatively low energy is chosen to avoid any contamination with 210At and 210Po in the first experimental period. A beam current of 10 μA for 15 min (9 mCoulomb) yields 16.4 MBq 211At theoretically. Astatine is recovered from the target by a dry distillation technique, using various gases as a transport support-medium. The small all-quartz distillation-apparatus is heated up to 900 oC. Astatine is recovered in a small cool able vessel containing various trapping media. Distillation and trapping can be monitored with small radioactivity monitors. The whole system fits in a cubical 0.5 m glove box. Continuous monitoring of the distillation process allowed to optimize the heating rate, the transport support-medium and its flow-rate. Various trapping solutions were tested for their efficiency. Different beam dispersion in the target seems to influence the release and distillation of astatine from the molten bismuth-target. Two different release patterns were observed. The first

  14. Retention Initiatives are Employed in Academic Libraries, Although not Necessarily for this Purpose. A Review of: Strothmann, M., & Ohler, L. A. (2011). Retaining academic librarians: By chance or by design? Library Management, 32(3), 191-208. doi: 10.1108/01435121111112907

    OpenAIRE

    Laura Newton Miller

    2011-01-01

    Objective – To study methods that support retention of academic librarians.Design – Exploratory research using an online survey; non-random sample.Setting – Academic libraries, nearly all located within the U.S. (97.2%). Subjects – A total of 895 professional academic librarians.Methods – The researchers sent an online survey link to professional electronic mail lists and directly to heads of Association of Research Libraries (ARL) member libraries. The 23-item survey was available from Febru...

  15. Retention Initiatives are Employed in Academic Libraries, Although not Necessarily for this Purpose. A Review of: Strothmann, M., & Ohler, L. A. (2011. Retaining academic librarians: By chance or by design? Library Management, 32(3, 191-208. doi: 10.1108/01435121111112907

    Directory of Open Access Journals (Sweden)

    Laura Newton Miller

    2011-09-01

    Full Text Available Objective – To study methods that support retention of academic librarians.Design – Exploratory research using an online survey; non-random sample.Setting – Academic libraries, nearly all located within the U.S. (97.2%. Subjects – A total of 895 professional academic librarians.Methods – The researchers sent an online survey link to professional electronic mail lists and directly to heads of Association of Research Libraries (ARL member libraries. The 23-item survey was available from February 19, 2007, through March 9, 2007, and contained questions about the professional experience of respondents, their libraries, and their universities. Subjects were asked to identify retention activities that were currently offered at their workplaces (both library-specific and university-wide and to rate their satisfaction for each available initiative. The list contained fifteen initiatives based on the researchers’ literature review.Main Results – Almost half (46.3% of respondents were 50 or older and 7.5% under 30 years old, leaving 46.2% between the ages of 30-50 years old (although this percentage is not explicitly stated in the paper except in a table. Nearly half of the subjects were in the first ten years of their careers. 80.2% had held between one and four professional positions in their careers, and even when length of professional experience was factored out, age had no effect on the number of positions held. Most job turnover within the past three years (3 or fewer open positions was in public service, while other areas of the library (i.e., technical services, systems, and administration reported zero open positions. Only 11.3% of respondents noted that their libraries have deliberate, formal retention programs in place. Despite this, there are several library- and university-based initiatives that can be considered to help with retention. The most reported available library-based retention initiative was the provision of funding to attend conferences (86.8%. Librarians also frequently reported flexible schedules, support and funding for professional development and access to leadership programs. University-based retention programs included continuing education funding, new employee orientations, faculty status, and the chance to teach credit-bearing courses. Only 22.2% of subjects reported formal mentoring programs as a retention strategy. Librarians were very or somewhat satisfied with schedule flexibility (79.6%. They were generally satisfied with other initiatives reported. In response to 22 five-point Likert scale descriptions of positive library work environments, subjects most agreed with statements that allowed librarians to have control of their professional duties, that allowed for personal or family obligations, and that supported professional development. Librarians agreed less often regarding statements about salaries, research support, and opportunities for advancement.Conclusion – Academic librarians are involved in and are benefitting from some library and university-based retention initiatives, even though retention may not be the primary strategic goal.

  16. Enhanced 1-meter Composite Grayscale Image of the Sidescan-Sonar Data From National Oceanic and Atmospheric Administration (NOAA) Survey H11079 of the Sea Floor in Great Round Shoal Channel, Offshore Massachusetts (H11079_UTM19_1MRSSS.TIF, UTM Zone 19)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The U.S. Geological Survey (USGS), in cooperation with the National Oceanic and Atmospheric Administration (NOAA) and the Massachusetts Office of Coastal Zone...

  17. Inclusive measurement of (p,πsup(-)xn) double charge exchange reactions on bismuth from threshold to 800 MeV

    International Nuclear Information System (INIS)

    The energy dependence of the total angle-integrated cross section for the production of astatine isotopes from (p,πsup(-)xn) double charge exchange reactions on bismuth (sup(209)Bi) was measured from 120 to 800 MeV using activation and radiochemical techniques. Chemical yields were estimated by direct radioassaying of sup(211)At activity in thin (approximately 1 mg/cmsup(2)), irradiated bismuth targets. Calculations of the contributions of secondary (2-step) reactions to these measured astatine yields were performed, based partially upon the observed sup(211)At activity although even at the highest energies, the contribution to products lighter than sup(207)At was negligible. These data for products with as many as 7 neutrons removed from the doubly coherent product (sup(210)At) display nearby gaussian shapes for the mass distributions of the astatine residues with the maximum occurring for about sup(204)At. The most probable momentum transfer deduced from these distributions for the initial πsup(-) production step was 335 MeV/c. The observed excitation functions display a behaviour similar to that observed for the yield of sup(210)Po from a (p,πsup(O)) reaction on sup(209)Bi, but radically different from that observed for inclusive πsup(-) reactions on a heavy nucleus. These data are discussed in terms of recent theoretical approaches to negative pion production from bismuth. In addition, a simple, schematic model is developed to treat the rapidly decreasing percentage of the total inclusive πsup(-) emission which is observed for this double charge exchange reaction. This model reflects the capacity of a nucleus to a source of internal energetic protons

  18. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    OpenAIRE

    BAYRAM, Ali

    1998-01-01

    In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 1...

  19. Human radiation studies: Remembering the early years: Oral history of Dr. Patricia Wallace Durbin, Ph.D., conducted November 11, 1994

    International Nuclear Information System (INIS)

    This report is a transcript of an interview of Dr. Patricia Wallace Durbin by representatives of the US DOE Office of Human Radiation Research. Dr. Durbin was selected for this interview because of her knowledge of the human plutonium injections and her recollections of key figures, especially Joseph Hamilton. After a brief biographical sketch Dr. Durbin discusses her loss of research funding from DOE, her recollections concerning research into strontium metabolism as part of Project Sunshine, her recollections relating to the rationale for studies of human metabolism of radionuclides, her remembrances of Dr. Hamilton's Astatine and Plutonium research, and her experiences in gathering archival records concerning these researches

  20. AcEST: BP919886 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000130_C09 570 Adiantum capillus-veneris mRNA. clone: YMU001_000130_C09. BP919886 - Show ... ltransferase (Fragment) OS=Sequoia sempervirens GN=pat ... PE=4 SV=1 Length = 191 Score = 121 bits (304), Exp ... bosyltransferase (Fragment) OS=Thuja standishii GN=pat ... PE=4 SV=1 Length = 191 Score = 118 bits (296), Exp ... yltransferase (Fragment) OS=Thujopsis dolabrata GN=pat ... PE=4 SV=1 Length = 191 Score = 118 bits (295), Exp ... transferase) (Fragment) OS=Cryptomeria japonica GN=pat ... PE=4 SV=1 Length = 191 Score = 118 bits (295), Exp ...

  1. Dicty_cDB: Contig-U12752-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available s (55), Expect = 1e-24 Identities = 182/193 (94%) Strand = Plus / Plus Query: 11 gagtttgttgatttngatccnaaaccn...nnnnnnngnaaaantgntgctgttgtttcantt 70 ||||||||||||||||||||||||||| || |||||||||||||||||||||||||| Sbjct: 11 gagtttgttgatttngatccna...Sbjct: 131 ggtaaaaaangttntnactnctggaaancnagtcaaggngntncaanggccncntcaaan 190 Query: 191 gccna...tccccttt 203 ||||||||||||| Sbjct: 191 gccnatccccttt 203 >Contig-U11508-1 (Contig-U11508-1Q) /CSM_...) Strand = Plus / Plus Query: 11 gagtttgttgatttngatccnaaaccnnnnnnnngnaaaantgntgctgttgtttcantt 70 ||||||| |||

  2. Chondrogenic potential of human bone marrow mesenchymal stem cells and adipose-derived mesenchymal stem cells

    Czech Academy of Sciences Publication Activity Database

    Danisovic, L.; Lesný, Petr; Jendelová, Pavla; Teyssler, P.; Havlas, V.; Fujeriková, G.; Syková, Eva

    2006-01-01

    Roč. 8, Supplement 1 (2006), s. 191-191. ISSN 1465-3249. [ ISCT 2006. 04.05.2006-07.05.2006, Berlin] R&D Projects: GA MŠk(CZ) 1M0021620803; GA MZd(CZ) NR8121 Institutional research plan: CEZ:AV0Z50390512 Keywords : Mesenchymal Subject RIV: FH - Neurology

  3. Detailed characterisation and toxicity of organic extracts from PM2.5 collected in polluted city of Ostrava: the effect of meteorological conditions

    Czech Academy of Sciences Publication Activity Database

    Pokorná, M.; Milcová, Alena; Ciganek, M.; Neča, J.; Pěnčíková, K.; Mikuška, Pavel; Rössner ml., Pavel; Křůmal, Kamil; Večeřa, Zbyněk; Machala, M.

    2015. s. 191-191. [Annual Meeting European Environmental Mutagenesis and Genomics Society /44./. 23.08.2015-26.08.2015, Prague] R&D Projects: GA ČR(CZ) GBP503/12/G147 Institutional support: RVO:68081715 ; RVO:68378041 Keywords : PM2.5 * PAHs * dioxin-like toxicity Subject RIV: CB - Analytical Chemistry, Separation

  4. 75 FR 9359 - Drawback of Internal Revenue Excise Tax

    Science.gov (United States)

    2010-03-02

    ... Federal Register (74 FR 52928) proposing changes to parts 113 and 191 within title 19 of the Code of... the Federal Register (74 FR 52928) on October 15, 2009, so that relevant issues involved in the... Parts 113 and 191 RIN 1505-AC18 Drawback of Internal Revenue Excise Tax AGENCY: Customs and...

  5. Effect of N-acetylcasteine on expression and activity of MnSOD in chronically hypoxic and normoxic rat hearts

    Czech Academy of Sciences Publication Activity Database

    Balková, P.; Nováková, O.; Novák, F.; Neckář, Jan; Milerová, Marie; Kolář, František

    Elsevier. Roč. 42, č. 6 (2007), S191-S191. ISSN 0022-2828. [World Congress of the ISHR /19./. 22.06.2007-26.06.2007, Bologna] R&D Projects: GA ČR(CZ) GA305/07/0875 Institutional research plan: CEZ:AV0Z50110509 Keywords : MnSOD * hypoxia * cardioprotection Subject RIV: ED - Physiology

  6. An analytic study of applying miller cycle to reduce nox emission from petrol engine

    OpenAIRE

    Wang, Yaodong; Lin, Lin; Roskilly, Antony P.; Zeng, Shengchuo; Huang, Jincheng; He, Yunxin; Huang, Xiaodong; Huang, Huilan; Wei, Haiyan; Li, Shangping; Yang, J

    2007-01-01

    An analytic study of applying miller cycle to reduce nox emission from petrol engine correspondence: Corresponding author. Tel.: +0044 191 2223522; fax: +0044 191 2225491. (Wang, Yaodong) (Wang, Yaodong) School of Marine Science and Technology, Newcastle University - Newcastle upon Tyne--> , NE1 7RU--> - UNITED KINGDOM (Wang, Yaodong) Mechanical Engineering College, Guangxi University - Nanning--...

  7. EST Table: CN374994 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CN374994 rzhswab0_003238 10/09/28 72 %/191 aa ref|XP_970542.1| PREDICTED: similar to brix...26-PA 10/09/10 72 %/191 aa gi|91090402|ref|XP_970542.1| PREDICTED: similar to brix domain-containing protein 2 [Tribolium castaneum] FS911686 L12 ...

  8. Functionally important amino acids in the TCR revealed by immunoselection of membrane TCR-negative T cells

    DEFF Research Database (Denmark)

    Caspar-Bauguil, S; Arnaud, J; Gouaillard, C;

    1994-01-01

    guanine to adenine change in the second nucleotide of the triplet coding for cysteine191 resulting in a cysteine to tyrosine exchange. Cysteine191 is the C-terminal cysteine involved in the intrachain disulfide bond in the C domain of the Ti beta chain; thus, the 3P11 Ti beta chain did not contain this...

  9. NCBI nr-aa BLAST: CBRC-MLUC-01-0516 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MLUC-01-0516 ref|YP_001875823.1| hypothetical protein Emin_0933 [Elusimicrobiu...m minutum Pei191] gb|ACC98486.1| hypothetical protein Emin_0933 [Elusimicrobium minutum Pei191] YP_001875823.1 5e-11 24% ...

  10. NCBI nr-aa BLAST: CBRC-MLUC-01-0516 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MLUC-01-0516 ref|YP_001875573.1| hypothetical protein Emin_0681 [Elusimicrobiu...m minutum Pei191] gb|ACC98236.1| hypothetical protein Emin_0681 [Elusimicrobium minutum Pei191] YP_001875573.1 1e-08 21% ...

  11. NCBI nr-aa BLAST: CBRC-MLUC-01-0516 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MLUC-01-0516 ref|YP_001875427.1| hypothetical protein Emin_0535 [Elusimicrobiu...m minutum Pei191] gb|ACC98090.1| hypothetical protein Emin_0535 [Elusimicrobium minutum Pei191] YP_001875427.1 6e-07 22% ...

  12. Quartz and feldspar distribution in continental shelf sediments of east coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Rao, V.P.; VijayKumar, B.

    stream_size 5 stream_content_type text/plain stream_name Indian_J_Mar_Sci_19_191.pdf.txt stream_source_info Indian_J_Mar_Sci_19_191.pdf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 ...

  13. Protein: MPB1 [TP Atlas

    Lifescience Database Archive (English)

    Full Text Available MPB1 Related chemokines CCL3 G0S19-1, MIP1A, SCYA3 C-C motif chemokine 3 G0/G1 switch regulatory ... ein 19-1, Macrophage inflammatory protein 1-alpha, PAT ... 464.1, SIS-beta, Small-inducible cytokine A3, Tons ...

  14. EFFECT OF MECHANICAL PROPERTIES OF MARTENSITE AND LOADING RATE ON DUAL PHASE STEELS

    Directory of Open Access Journals (Sweden)

    Ali BAYRAM

    1998-03-01

    Full Text Available In this study, steel sheet materials were used in order to obtain dual-phase steel. Specimens for this purpose have been annealed in ferrite + astatine regions at the temperatures of 740, 760, 800 and 820 °C. The specimens were annealed at the different temperatures with corresponding times 20, 40 and 60 minutes and quenched into water. As a result of this dual-phase steels at different ferrite + martensite ratio were produced. Sheet specimens were tested at the range of loading rates of 10, 50 and 259 mm/min. Strength properties of dual-phase steels were investigated depending on annealing temperature, ratio of martensite and loading rate.

  15. A route for polonium 210 production from alpha-particle irradiated bismuth-209 target

    International Nuclear Information System (INIS)

    A method is proposed for production of polonium-210 via the 209Bi(α,3n)210 At nuclear reaction. Bombardment of a bismuth-209 target was performed with a 37 MeV alpha-particle beam that leads to the production of astatine-210 (T1/2 = 8.1 h), which decays to polonium-210. It is purified from the bismuth target matrix by employing liquid-liquid extraction using tributyl phosphate (TBP) in para-xylene from 7 M hydrochloric acid. Back extraction of polonium-210 was performed by 9 M nitric acid. This method allows to purify a tracer amount of Po-210 (2.6 x 10-13 mol) from macroscopic amount of Bi (2.8 x 10-2 mol).

  16. Effective bond orders from two-step spin–orbit coupling approaches: The I{sub 2}, At{sub 2}, IO{sup +}, and AtO{sup +} case studies

    Energy Technology Data Exchange (ETDEWEB)

    Maurice, Rémi, E-mail: remi.maurice@subatech.in2p3.fr; Montavon, Gilles [SUBATECH, CNRS UMR 6457, IN2P3/EMN Nantes/Université de Nantes, 4 rue Alfred Kastler, BP 20722, 44307 Nantes Cedex 3 (France); Réal, Florent; Gomes, André Severo Pereira; Vallet, Valérie [Laboratoire PhLAM, CNRS UMR 8523, Université de Lille, 59655 Villeneuve d’Ascq Cedex (France); Galland, Nicolas [CEISAM, UMR CNRS 6230, Université de Nantes, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3 (France)

    2015-03-07

    The nature of chemical bonds in heavy main-group diatomics is discussed from the viewpoint of effective bond orders, which are computed from spin–orbit wave functions resulting from spin–orbit configuration interaction calculations. The reliability of the relativistic correlated wave functions obtained in such two-step spin–orbit coupling frameworks is assessed by benchmark studies of the spectroscopic constants with respect to either experimental data, or state-of-the-art fully relativistic correlated calculations. The I{sub 2}, At{sub 2}, IO{sup +}, and AtO{sup +} species are considered, and differences and similarities between the astatine and iodine elements are highlighted. In particular, we demonstrate that spin–orbit coupling weakens the covalent character of the bond in At{sub 2} even more than electron correlation, making the consideration of spin–orbit coupling compulsory for discussing chemical bonding in heavy (6p) main group element systems.

  17. Effective bond orders from two-step spin–orbit coupling approaches: The I2, At2, IO+, and AtO+ case studies

    International Nuclear Information System (INIS)

    The nature of chemical bonds in heavy main-group diatomics is discussed from the viewpoint of effective bond orders, which are computed from spin–orbit wave functions resulting from spin–orbit configuration interaction calculations. The reliability of the relativistic correlated wave functions obtained in such two-step spin–orbit coupling frameworks is assessed by benchmark studies of the spectroscopic constants with respect to either experimental data, or state-of-the-art fully relativistic correlated calculations. The I2, At2, IO+, and AtO+ species are considered, and differences and similarities between the astatine and iodine elements are highlighted. In particular, we demonstrate that spin–orbit coupling weakens the covalent character of the bond in At2 even more than electron correlation, making the consideration of spin–orbit coupling compulsory for discussing chemical bonding in heavy (6p) main group element systems

  18. Different ways to improve the clinical effectiveness of radioimmunotherapy in solid tumors

    Directory of Open Access Journals (Sweden)

    Chatal Jean-Francois

    2009-09-01

    Full Text Available Radioimmunotherapy (RIT has been proven effective in the treatment of radiosensitive non-Hodgkin lymphoma but, for radioresistant solid tumors, new approaches are necessary to improve the clinical effectiveness. A real improvement has been the introduction of the pretargeting technology which appeared to be able to significantly increase tumor-to-normal organ uptake ratios.Another very promising approach consists in associating RIT with other treatment modalities. Finally the use of alpha particle-emitting radionuclides such as astatin-211 or bismuth-213 (alpha-RIT should allow to efficiently eradicate disseminated microscopic clusters of tumor cells or isolated tumor cells which fit well with the short path length of alpha particles.

  19. Sequential radioimmunotherapy with 177Lu- and 211At-labeled monoclonal antibody BR96 in a syngeneic rat colon carcinoma model

    DEFF Research Database (Denmark)

    Eriksson, Sophie E; Elgström, Erika; Bäck, Tom;

    2014-01-01

    UNLABELLED: Alpha-particle emitters, such as astatine-211 (211At), are generally considered suitable for the treatment of small cell clusters due to their short path length, while beta-particle emitters, for example, Lutetium-177 (177Lu), have a longer path length and are considered better for...... small, established tumors. A combination of such radionuclides may be successful in regimens of radioimmunotherapy. In this study, rats were treated by sequential administration of first a 177Lu-labeled antibody, followed by a 211At-labeled antibody 25 days later. METHODS: Rats bearing solid colon...... carcinoma tumors were treated with 400 MBq/kg body weight 177Lu-BR96. After 25 days, three groups of animals were given either 5 or 10 MBq/kg body weight of 211At-BR96 simultaneously with or without a blocking agent reducing halogen uptake in normal tissues. Control animals were not given any 211At-BR96...

  20. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    CERN Document Server

    Marsh, B A; Imai, N; Seliverstov, M D; Rothe, S; Sels, S; Capponi, L; Rossel, R E; Franchoo, S; Wendt, K; Focker, G J; Kalaninova, Z; Sjoedin, A M; Popescu, L; Nicol, T; Huyse, M; Radulov, D; Atanasov, D; Kesteloot, N; Borgmann, Ch; Cocolios, T E; Lecesne, N; Ghys, L; Pauwels, D; Rapisarda, E; Kreim, S; Liberati, V; Wolf, R N; Andel, B; Schweikhard, L; Lane, J; Derkx, X; Kudryavtsev, Yu; Zemlyanoy, S G; Fedosseev, V N; Lynch, K M; Rosenbusch, M; Van Duppen, P; Lunney, D; Manea, V; Barzakh, A E; Andreyev, A N; Truesdale, V; Flanagan, K T; Molkanov, P L; Koester, U; Van Beveren, C; Wienholtz, F; Goodacre, T Day; Antalic, S; Bastin, B; De Witte, H; Fink, D A; Fedorov, D V

    2013-01-01

    At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar fr...

  1. Development of 211At Chemistry for Labelling Biomolecules

    International Nuclear Information System (INIS)

    Our studies have demonstrated that high recovery of 211At can be obtained using a “wet chemistry” approach to isolation from the bismuth target. We have also demonstrated that direct labelling of antibody-B10 conjugates with 211At can be performed in high yields, and that the astatinated antibodies are stable to in vivo deastatination. While these results will allow us to enter clinical studies with 211At-labelled antibodies, the chemistry associated with 211At is not fully understood. Therefore, it is important that many more basic studies to be conducted with 211At, so the optimal labelling reagent for each type of disease-targeting agent becomes apparent

  2. Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation status

    DEFF Research Database (Denmark)

    Lyckesvärd, Madeleine Nordén; Delle, Ulla; Kahu, Helena;

    2014-01-01

    Childhood exposure to ionizing radiation increases the risk of developing thyroid cancer later in life and this is suggested to be due to higher proliferation of the young thyroid. The interest of using high-LET alpha particles from Astatine-211 ((211)At), concentrated in the thyroid by the same...... levels of γH2AX decreased during the first 24h in both cycling and stationary cultures and complete repair was seen in all cultures but cycling cells exposed to (211)At. Compared to stationary cells alpha particles were more harmful for cycling cultures, an effect also seen at the pChk2 levels...... cultures at a modest level of damage, clearly demonstrating that cell cycle status influences the relative effectiveness of alpha particles....

  3. An improved synthesis of an 125I and 211At labelled benzamide for melanoma imaging

    International Nuclear Information System (INIS)

    Recent studies have indicated that benzamides can exhibit affinity for malignant melanoma and may be exploited diagnostically in the treatment of this cancer. Radioiodinated N-(2-diethylaminoethyl)-3-[123I/131I]iodo-4-methoxybenzamide (*I-IMBA) is a benzamide with promising diagnostic properties. A new synthesis procedure was developed to obtain 125I-IMBA suitable for use in vivo. The assets of the procedure include the use of less toxic reagents and better reproducible results when radiolabelling the precursor. The procedure also facilitates the synthesis of the astatinated N-(2-diethylaminoethyl)-3-[211At]astatine-4-methoxybenzamide (211At-AMBA), a new benzamide with a therapeutic potential. The regiospecific no-carrier-added 125I- and 211At-labeling of the benzamide is performed by demetalation of an organotin precursor. Using tributylstannyl as a leaving group, the radiochemical yield obtained after 15 minutes of reaction was 70 %-90 % for both 125I-IMBA and 211At-AMBA. The labelling was performed in a solution of MeOH:AcOH with NCS as the oxidising agent. The organotin precursor N-(2-diethylaminoethyl)-3-(tri-n-butylstannyl)-4-methoxy-benzamide was synthesized from 3-bromo-4-methoxybenzoic acid, with n-BuLi (2 eq) and Bu3SnCl (1 eq) in THF, giving 3-(tri-n-butylstannyl)-4-methoxybenzoic acid. The amide function was introduced by converting the acid group into an active N-succinimidyl-ester, a good leaving group in the reaction with 2-(diethylamino)ethylamine. The overall yield of the organotin precursor was 65 %

  4. New developments of the in-source spectroscopy method at RILIS/ISOLDE

    Energy Technology Data Exchange (ETDEWEB)

    Marsh, B.A., E-mail: bruce.marsh@cern.ch [CERN, CH-1211 Geneva (Switzerland); Andel, B. [Comenius University, Bratislava (Slovakia); Andreyev, A.N. [University of York, Department of Physics, York YO10 5DD (United Kingdom); Antalic, S. [Comenius University, Bratislava (Slovakia); Atanasov, D. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Barzakh, A.E. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Bastin, B. [Grand Accérateur National d’Ions Lourds (GANIL), Bd Henri Becquerel, F-14076 Caen (France); Borgmann, Ch. [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Capponi, L. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Cocolios, T.E.; Day Goodacre, T. [CERN, CH-1211 Geneva (Switzerland); University of Manchester, Manchester (United Kingdom); Dehairs, M. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Derkx, X. [University of the West of Scotland, School of Engineering, Paisley PA1 2BE (United Kingdom); De Witte, H. [KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Fedorov, D.V. [Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, 188300 Gatchina (Russian Federation); Fedosseev, V.N.; Focker, G.J. [CERN, CH-1211 Geneva (Switzerland); Fink, D.A. [Ruprecht-Karls Universität, Seminarstr. 2, 69117 Heidelberg (Germany); CERN, CH-1211 Geneva (Switzerland); Flanagan, K.T. [University of Manchester, Manchester (United Kingdom); Franchoo, S. [CSNSM-IN2P3-CNRS, Université Paris-Sud, 91406 Orsay (France); and others

    2013-12-15

    Highlights: • Upgrade of the lasers, detectors and data acquisition for in-source resonance ionization spectroscopy at ISOLDE. • First use of the ISOLTRAP MR-ToF MS in combination with laser spectroscopy at ISOLDE. • Resonance ionization of astatine for the study of its nuclear structure. -- Abstract: At the CERN ISOLDE facility, long isotope chains of many elements are produced by proton-induced reactions in target materials such as uranium carbide. The Resonance Ionization Laser Ion Source (RILIS) is an efficient and selective means of ionizing the reaction products to produce an ion beam of a chosen isotope. Coupling the RILIS with modern ion detection techniques enables highly sensitive studies of nuclear properties (spins, electromagnetic moments and charge radii) along an isotope chain, provided that the isotope shifts and hyperfine structure splitting of the atomic transitions can be resolved. At ISOLDE the campaign to measure the systematics of isotopes in the lead region (Pb, Bi, Tl and Po) has been extended to include the gold and astatine isotope chains. Several developments were specifically required for the feasibility of the most recent measurements: new ionization schemes (Po, At); a remote controlled narrow line-width mode of operation for the RILIS Ti:sapphire laser (At, Au, Po); isobar free ionization using the Laser Ion Source Trap, LIST (Po); isobar selective particle identification using the multi-reflection time-of-flight mass separator (MR-ToF MS) of ISOLTRAP (Au, At). These are summarized as part of an overview of the current status of the in-source resonance ionization spectroscopy setup at ISOLDE.

  5. Study of dilepton production in association with leading hadron at RHIC and LHC energies

    Czech Academy of Sciences Publication Activity Database

    Basso, E.; Goncalves, V. P.; Nemchik, J.; Pasechnik, R.; Šumbera, Michal

    Trieste: International School for Advanced Studies, 2015, s. 191. ISSN 1824-8039. [The European Physical Society Conference on High Energy Physics. Vienna (AT), 22.07.2015-29.07.2015] R&D Projects: GA ČR GA13-20841S; GA MŠk(CZ) LG13031 Institutional support: RVO:61389005 Keywords : RHIC * LHC * dilepton Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders http://pos.sissa.it/archive/conferences/234/191/EPS-HEP2015_191.pdf

  6. Theoretical analysis of an Uqp(u2) model for the congruent superdeformed rotational bands

    International Nuclear Information System (INIS)

    Superdeformed rotational bands in 191-192-193-194Hg are analyzed by means of the Uqp(u2) model. An overall and excellent agreement between the calculated and observed spectra Eγ, kinematic moment of inertia J(1) and dynamic moment of inertia J(2), the aligned angular momentum (i = ω (J(1)(191-193-194Hg)-J(1)(192Hg))) is obtained. Further more, the nuclear softness in 191-192-193-194Hg are calculated by means of the Uqp(u2) model and drawn into the nuclear configuration analysis

  7. Reaction of N-hydroxyguanidine with the ferrous-oxy state of a heme peroxidase cavity mutant: A model for the reactions of nitric oxide synthase†

    OpenAIRE

    Nigro, Alycen Pond; Goodin, David B.

    2010-01-01

    Yeast cytochrome c peroxidase was used to construct a model for the reactions catalyzed by the second cycle of nitric oxide synthase. The R48A/W191F mutant introduced a binding site for N-hydroxyguanidine near the distal heme face and removed the redox active Trp-191 radical site. Both the R48A and R48A/W191F mutants catalyzed the H2O2 dependent conversion of N-hydroxyguanidine to N-nitrosoguanidine. It is proposed that these reactions proceed by direct one-electron oxidation of NHG by the Fe...

  8. Dicty_cDB: Contig-U12766-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available = 280/280 (100%) Strand = Plus / Plus Query: 11 tgatttngatccnaaaccnttnntttgnaaaactgntgctgntgnttcanttggngntgc... 70 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 11 tgatttngatccna...aancnanncaaggngntncnanggccccntcaaangccnatcc 190 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||... Sbjct: 131 aggttntgnctactggaaancnanncaaggngntncnanggccccntcaaangccnatcc 190 Query: 191 cctttangaaancnatccntcnggnggngaaaanccna...tttntnctagccccnattancn 250 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sb

  9. Dicty_cDB: Contig-U14141-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available tities = 257/263 (97%) Strand = Plus / Plus Query: 11 aatccnaaacctggnccccaatattatccccnancnactttnccnntatttgaa...tccccn 70 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct: 11 aatccna...aacctggnccccaatattatccccnancnactttnccnntatttgaatccccn 70 Query: 71 aangnttttganaaatttganatnganaccntgn...| Sbjct: 131 anttatcnacaanatcnagcagntaaannattaaanaaacaaggntggagntntnataaa 190 Query: 191 aaanatntcncctggnttanaanacatgaagnaccna...aanaaatnccnaangaatttgaa 250 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| S

  10. Dicty_cDB: Contig-U14270-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available |||||||||| Sbjct: 191 gttcaacacaatgcngntcngcaacatgctganccagntgccaagccagccgaattaacc 250 Query: 251 natgcccnagaattncaacaagaacaccna...||||||| Sbjct: 251 natgcccnagaattncaacaagaacaccnaagncaagnagctctcgcaaaacnncnngct 3...10 Query: 311 cgtattagncaacaaaatcntgtcaaacaagcngcccnanagaaacgaacctcgcnacgt 370 |||||||||||||||||||||||||||||...||||||||||||||||||||||||||||||| Sbjct: 311 cgtattagncaacaaaatcntgtcaaacaagcngcccnanagaaacgaacctcgcnacgt 370 ...ct: 219 cngctgctcngggggctgccaanccagttcaacacaatgcngntcngcaacatgctganc 160 Query: 225 cagntgccaagccagccgaattaaccnatgcccna

  11. Digestibility of total and phytate phosphorus

    Czech Academy of Sciences Publication Activity Database

    Marounek, Milan; Skřivanová, V.; Dvořák, R.

    2004-01-01

    Roč. 49, č. 6 (2004), s. 191-196. ISSN 0375-8427 Institutional research plan: CEZ:AV0Z5045916 Keywords : digestion * milk * starter concentrate Subject RIV: ED - Physiology Impact factor: 0.790, year: 2004

  12. Althusser, Marx a neempiristická teorie dějin

    Czech Academy of Sciences Publication Activity Database

    Kužel, Petr

    2013-01-01

    Roč. 10, č. 2 (2013), s. 191-208. ISSN 1214-7249 Institutional support: RVO:67985955 Keywords : empiricism * historical epistemology * Louis Althusser * Karl Marx Subject RIV: AA - Philosophy ; Religion

  13. TAA1-Mediated Auxin Biosynthesis Is Essential for Hormone Crosstalk and Plant Development

    Czech Academy of Sciences Publication Activity Database

    Stepanova, A.N.; Robertson-Hoyt, J.; Yun, J.; Benavente, L.M.; Xie, D.Y.; Doležal, Karel; Schlereth, A.; Jürgens, G.; Alonso, J.M.

    2008-01-01

    Roč. 133, č. 1 (2008), s. 177-191. ISSN 0092-8674 Institutional research plan: CEZ:AV0Z50380511 Keywords : CELLBIO * SIGNALING * DEVBIO Subject RIV: CE - Biochemistry Impact factor: 31.253, year: 2008

  14. 77 FR 8282 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

    Science.gov (United States)

    2012-02-14

    ... Services, Inc., Global Quality Assurance Department. 81,149 CQMS Razer, Jean Simpson Mansfield, LA February..., Robert Half, etc. 81,191 Bristol, Inc., A Business Watertown, CT August 19, 2011. Unit of...

  15. Grammaticalization and lexicalization effects in participial morphology. A Construction Grammar approach to language change

    Czech Academy of Sciences Publication Activity Database

    Fried, Mirjam

    Amsterdam : Benjamins, 2010 - (Van Linden, A.; Verstraete, J.; Davidse, K.), s. 191-223 ISBN 978-90-272-0675-6 Institutional research plan: CEZ:AV0Z90610518 Keywords : grammaticalization * morphology * construction grammar Subject RIV: AI - Linguistics

  16. Od posvátné jednoty k rozštěpené společnosti. Povaha a problémy přechodného období od listopadu 1989 do června 1990

    Czech Academy of Sciences Publication Activity Database

    Suk, Jiří

    Praha: Epocha, 2010, s. 182-191. (Erudica. 16). ISBN 978-80-7425-078-1 Institutional research plan: CEZ:AV0Z80630520 Keywords : Velvet revolution * civic forum * free elections Subject RIV: AB - History

  17. Recalled, Present, and Predicted Satisfaction in Stages of the Family Life Cycle in New Zealand

    Science.gov (United States)

    Smart, Mollie S.; Smart, Russell C.

    1975-01-01

    Satisfaction in family living was studied in a New Zealand sample of 191 men and 285 women in the eight stages of the family life cycle. Results were compared with Rollins and Feldman's American sample. (Author)

  18. Main: 1E4N [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available n Complexes Proc.Nat.Acad.Sci.Usa V. 97 13555 2000 Glycoside Hydrolase, Beta-Glucosidase, Family 1, Retention Of The Anomeric Configu...ration, Inactive Mutant E191d, Complex With Dimboa SWS:B

  19. Main: 1.00E+55 [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available figuration, Inactive Mutant E191d, Complex With Dhurrin ...urrin Complexes Proc.Nat.Acad.Sci.Usa V. 97 13555 2000 Glycoside Hydrolase, Beta-Glucosidase, Family 1, Retention Of The Anomeric Con

  20. Main: 1.00E+56 [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available figuration, Inactive Mutant E191d, Complex With Dimboa-G...urrin Complexes Proc.Nat.Acad.Sci.Usa V. 97 13555 2000 Glycoside Hydrolase, Beta-Glucosidase, Family 1, Retention Of The Anomeric Con

  1. Functional identification of the non-specific nuclease from white spot syndrome virus

    International Nuclear Information System (INIS)

    The product encoded by the wsv191 gene from shrimp white spot syndrome virus (WSSV) is homologous with non-specific nucleases (NSN) of other organisms. To functionally identify the protein, the wsv191 gene was expressed in Escherichia coli as a glutathione S-transferase (GST) fusion protein with 6His-tag at C-terminal. The fusion protein (termed as rWSSV-NSN) was purified using Ni-NTA affinity chromatography under denatured conditions, renatured and characterized by three methods. The results showed that rWSSV-NSN could hydrolyze both DNA and RNA. 5'-RACE result revealed that the transcription initiation site of the wsv191 gene was located at nucleotide residue G of the predicted ATG triplet. Therefore, we concluded that the next ATG should be the genuine translation initiation codon of the wsv191 gene. Western blot analysis revealed that the molecular mass of natural WSSV-NSN was 37 kDa

  2. Dicty_cDB: Contig-U12712-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available lcknmlsiesrr egsnldpifh**sy**gnsccndsig*rycslsfkilvc*yyein*rrekekn*rr*sfk *tkkatttattk*fiittycwrtcsrfqsslllk... 11 ttggtatattggggaggaggtaaccaaacaattgaaatataaaatatttgaaactatcta 70 Query: 71 tgataatctctttc...: 71 tgataatctctttcgaaccgttatgaaatgcacatcagagacaaagtataagtataattt 130 Query: 131 aggctgtttctgctattcttactttaagatc...attcaatccgatcaccaagtgacctctgc 190 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| Sbjct...: 131 aggctgtttctgctattcttactttaagatcattcaatccgatcaccaagtgacctctgc 190 Query: 191 tagattc

  3. ABO blood groups and pancreatic cancer risk and survival: Results from the PANcreatic Disease ReseArch (PANDoRA) consortium

    Czech Academy of Sciences Publication Activity Database

    Rizzato, C.; Campa, D.; Pezzilli, R.; Souček, P.; Greenhalf, W.; Capurso, G.; Talar-Wojnarowska, R.; Heller, A.; Jamroziak, K.; Khaw, K. T.; Key, T.; Bambi, F.; Landi, S.; Mohelníková-Duchoňová, B.; Vodičková, Ludmila; Buechler, M. W.; Bugert, P.; Vodička, Pavel; Neoptolemos, J. P.; Werner, J.; Hoheisel, J. D.; Bauer, A. S.; Giese, N.; Canzian, F.

    2013-01-01

    Roč. 29, č. 4 (2013), s. 1637-1644. ISSN 1021-335X Institutional support: RVO:68378041 Keywords : pancreatic cancer * genetic susceptibility * cancer risk Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.191, year: 2013

  4. Neither revolution, nor resignation: (re)democratizing contemporary planning praxis : A commentary on Allmendinger and Haughton's "Spatial planning, devolution, and new planning spaces"

    OpenAIRE

    Metzger, Jonathan

    2011-01-01

    Jonathan Metzger, 2011. The definitive, peer-reviewed and edited version of this article is published in Environment and Planning. C, Government and Policy, 29, 2, 191-196, 2011, doi:10.1068/c10210. QC 20110714

  5. Impact of teaching session on concepts of palliative care in medical undergraduates.

    Directory of Open Access Journals (Sweden)

    Sirisha Annavarapu

    2016-02-01

    Conclusions: Concept of palliative care was poor among medical undergraduates. Health care providers can overcome by knowledge construction, interrelation between practice and evidence based medicine. [Int J Basic Clin Pharmacol 2016; 5(1.000: 188-191

  6. Rings without a lord? Enigmatic fossils from the lower Palaeozoic of Bohemia and the Carnic Alps

    Czech Academy of Sciences Publication Activity Database

    Ferretti, A.; Cardini, A.; Crampton, J. S.; Serpagli, E.; Sheets, H. D.; Štorch, Petr

    2013-01-01

    Roč. 46, č. 2 (2013), s. 211-222. ISSN 0024-1164 Institutional support: RVO:67985831 Keywords : phosphatic rings * Problematica * Palaeozoic * morphometric analysis Subject RIV: DB - Geology ; Mineralogy Impact factor: 2.191, year: 2013

  7. Possible mechanism for differences in sensitivity to cis-platinum in human prostate tumor cell lines

    International Nuclear Information System (INIS)

    Two human prostate tumor cell lines which exhibit a 2.4-fold difference in sensitivity to cis-platinum (cis-191Pt) were found to possess slightly different sulphydryl contents, and the presence of a metallothionein-like zinc-binding protein was demonstrated in the line exhibiting relative resistance to cis-191Pt. Although these factors have been postulated to play a role in the mechanism(s) of resistance to cis-191Pt in other cell types, preliminary data in this report suggest that differences found in drug uptake and subsequent binding to DNA are most likely responsible for variations in cis-191Pt sensitivity displayed by these prostate tumor cell lines

  8. Effects of Individual and Group Contingencies on Disruptive Playground Behavior.

    Science.gov (United States)

    Thomas, Jerry R.; And Others

    1987-01-01

    Two treatments, an individual behavior contract and group behavior games, were studied to determine if they reduced disruptive playground behavior. The 191 subjects were second- and fifth-grade students in two public schools. Results are discussed. (Author/MT)

  9. Neuroimaging in TSC

    Science.gov (United States)

    ... detection of epileptogenic foci in tuberous sclerosis complex. Neurology 54:1976-84 Carlson C, Teutonico F, Elliott ... PET in 191 patients with tuberous sclerosis complex. Neurology 81(7):674-80 Curatolo P, Brinchi V ( ...

  10. Doktoritöö eesti värvinimetustest / Lembit Vaba

    Index Scriptorium Estoniae

    Vaba, Lembit

    2001-01-01

    Rets.: Oja, Vilja. Linguistic studies of Estonian colour terminology. Tartu : Tartu University Press, 2001. 191, [1] lk. : ill. (Dissertationes philologiae estonicae Universitatis Tartuensis. 1406-1325 ; 9). ISBN 9985565827

  11. AcEST: DK960243 [AcEST

    Lifescience Database Archive (English)

    Full Text Available |B0D415|B0D415_LACBS Predicted protein OS=Laccaria bicolor (st... 38 0.22 tr|A9X191|A9X191_PAPAN Sema domain, transmembran...GSLAVFIGGDAPPTSVAADA 82 >tr|A9X191|A9X191_PAPAN Sema domain, transmembrane domain, and cytoplasmic domain, 6C (Predicted...|Q5JR73|Q5JR73_HUMAN Sema domain, transmembrane domain (TM), a... 36 0.84 tr|Q5JR72|Q...5JR72_HUMAN Sema domain, transmembrane domain (TM), a... 36 0.84 tr|O60650|O60650_HUMAN Putative unchara...145 RKGAEPPAPLTSRAL--PPEPAPALLGGPSP-RPHECASPLRLDVPPEGRCASAP 196 >tr|Q5JR73|Q5JR73_HUMAN Sema domain, transmembrane domain (TM), an

  12. Field Plot Points for Voyageurs National Park Vegetation Mapping Project

    Data.gov (United States)

    National Park Service, Department of the Interior — A total of 191 vegetation field plot samples were collected at Voyageurs National Park and environs to support vegetation classification development. Teams of...

  13. Visit Itinerary

    CERN Multimedia

    2002-01-01

    The visit itinerary includes five area of halls 191 and 180:. End-Cap Toroid Integration Area . Barrel Toroid Integration Area . Cryogenic Test Facility for Toroid Magnets and Helium Pumps . Liquid Argon Cryostats Assembly Area . Central Solenoid Magnet Test Station

  14. Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression.

    OpenAIRE

    Samulski, R J; Chang, L S; Shenk, T

    1989-01-01

    A method is described for the production of recombinant adeno-associated virus (AAV) stocks that contain no detectable wild-type helper AAV. The recombinant viruses contained only the terminal 191 nucleotides of the AAV chromosome bracketing a nonviral marker gene. trans-Acting AAV functions were provided by a helper DNA in which the terminal 191 nucleotides of the AAV chromosome were substituted with adenovirus terminal sequences. Although the helper DNA did not appear to replicate, it expre...

  15. AcEST: DK951667 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TST38A01NGRL0012_A06 637 Adiantum capillus-veneris mRNA. clone: TST38A01NGRL0012_A06. 5' end seq ... NDC-DFDKAVEGCVSGAFWAAGQ 318 Query: 206 SCISVQRVYIHMDIY EVVKDALVEATSGLVKGDPLNEDTFIGPLIDESEAKRIEAWVEKA 385 + ... DANINKA--VESCMSGKF 267 Query: 191 YQSGQSCISVQRVYIHMDIY EVVKDALVEATSGLVKGDPLNEDTFIGPLIDESEAKRIEA 370 SGQ CI ... DS--DIKLAAKSAVKSKF 267 Query: 191 YQSGQSCISVQRVYIHMDIY EVVKDALVEATSGLVKGDPLNEDTFIGPLIDESEAKRIEA 370 +GQ CI ... DDA-DLDKAVEGALA 279 Query: 182 GAFYQSGQSCISVQRVYIHMDIY EVVKDALVEATSGLVKGDPLNEDTFIGPLIDESEAKR 361 F +GQ+C+ ...

  16. Prospects of using the second-order perturbation theory of the MP2 type in the theory of electron scattering by polyatomic molecules

    Czech Academy of Sciences Publication Activity Database

    Čársky, Petr

    2015-01-01

    Roč. 191, č. 2015 (2015), s. 191-192. ISSN 1551-7616 R&D Projects: GA MŠk OC09079; GA MŠk(CZ) OC10046; GA ČR GA202/08/0631 Grant ostatní: COST(XE) CM0805; COST(XE) CM0601 Institutional support: RVO:61388955 Keywords : electron-scattering * calculation of cross sections * second-order perturbation theory Subject RIV: CF - Physical ; Theoretical Chemistry

  17. 腰果酚甲醛铁聚合物热分解动力学的研究%Study on the Thermal Decomposition Kinetics of Cardanol-formaldehyde Polymers Using Thermogravimetry

    Institute of Scientific and Technical Information of China (English)

    刘小英

    2005-01-01

    用非等温热重法研究了腰果酚甲醛铁聚合物的热分解反应动力学.结果表明:腰果酚甲醛铁聚合物的热分解过程是一级反应,用Ozawa法和Reich法求得的平均活化能分别为191.1kJ/mol和191.0 kJ/mol.

  18. AcEST: BP913706 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000033_D03 582 Adiantum capillus-veneris mRNA. clone: YMU001_000033_D03. BP913706 CL485Co ... .....................done Score E Sequences producing s ignificant alignments: (bits) Value sp|P10978|POLX ... = 118/191 (61%) Frame = -2 Query: 581 ILGVGDVQLKFQNGS SLWLKSVRHVPAIRKSLISTGKLDDAGYVTVFGNSAWKISKGSMT 402 I ... (46%), Gaps = 8/191 (4%) Frame = -2 Query: 557 LKFQNGS SLWLKSVRHVPAIRKSLISTGKLDDAGYVTVFGNSAWKISKGSMTVAHGSK ... s = 24/216 (11%) Frame = -2 Query: 581 ILGVGDVQLKFQNGS SLWLKSVRHVPAIRKSLISTGKLDDAGYVTVFGNSAWKISKGSMT 402 I ...

  19. AcEST: BP912963 [AcEST

    Lifescience Database Archive (English)

    Full Text Available YMU001_000024_H01 584 Adiantum capillus-veneris mRNA. clone: YMU001_000024_H01. BP912963 CL485Co ... .....................done Score E Sequences producing s ignificant alignments: (bits) Value sp|P10978|POLX ... = 118/191 (61%) Frame = -1 Query: 581 ILGVGDVQLKFQNGS SLWLKSVRHVPAIRKSLISTGKLDDAGYVTVFGNSAWKISKGSMT 402 I ... (46%), Gaps = 8/191 (4%) Frame = -1 Query: 557 LKFQNGS SLWLKSVRHVPAIRKSLISTGKLDDAGYVTVFGNSAWKISKGSMTVAHGSK ... s = 24/216 (11%) Frame = -1 Query: 581 ILGVGDVQLKFQNGS SLWLKSVRHVPAIRKSLISTGKLDDAGYVTVFGNSAWKISKGSMT 402 I ...

  20. The enigmatic wind of 55 Cygni

    Czech Academy of Sciences Publication Activity Database

    Haucke, M.; Kraus, Michaela; Venero, R.O.J.; Cidale, L.S.; Nickeler, Dieter Horst; Tomić, S.; Curé, M.

    2013-01-01

    Roč. 56, č. 1 (2013), s. 191-194. E-ISSN 1669-9521 R&D Projects: GA ČR(CZ) GAP209/11/1198 Institutional support: RVO:67985815 Keywords : line profiles * stellar wind * spectroscopic observin Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics http://www.astronomiaargentina.org.ar/b56/2013baaa...56...191H.pdf

  1. A cation binding motif stabilizes the compound I radical of cytochrome c peroxidase.

    OpenAIRE

    Miller, M.A.; Han, G W; Kraut, J

    1994-01-01

    Cytochrome c peroxidase reacts with peroxide to form compound I, which contains an oxyferryl heme and an indolyl radical at Trp-191. The indolyl free radical has a half-life of several hours at room temperature, and this remarkable stability is essential for the catalytic function of cytochrome c peroxidase. To probe the protein environment that stabilizes the compound I radical, we used site-directed mutagenesis to replace Trp-191 with Gly or Gln. Crystal structures of these mutants revealed...

  2. A cation binding motif stabilizes the compound I radical of cytochrome c peroxidase.

    Science.gov (United States)

    Miller, M A; Han, G W; Kraut, J

    1994-11-01

    Cytochrome c peroxidase reacts with peroxide to form compound I, which contains an oxyferryl heme and an indolyl radical at Trp-191. The indolyl free radical has a half-life of several hours at room temperature, and this remarkable stability is essential for the catalytic function of cytochrome c peroxidase. To probe the protein environment that stabilizes the compound I radical, we used site-directed mutagenesis to replace Trp-191 with Gly or Gln. Crystal structures of these mutants revealed a monovalent cation binding site in the cavity formerly occupied by the side chain of Trp-191. Comparison of this site with those found in other known cation binding enzymes shows that the Trp-191 side chain resides in a consensus K+ binding site. Electrostatic potential calculations indicate that the cation binding site is created by partial negative charges at the backbone carbonyl oxygen atoms of residues 175 and 177, the carboxyl end of a long alpha-helix (residues 165-175), the heme propionates, and the carboxylate side chain of Asp-235. These features create a negative potential that envelops the side chain of Trp-191; the calculated free energy change for cation binding in this site is -27 kcal/mol (1 cal = 4.184J). This is more than sufficient to account for the stability of the Trp-191 radical, which our estimates suggest is stabilized by 7.8 kcal/mol relative to a Trp radical in solution. PMID:7972020

  3. THE STUDY OF RNA INTERFERENCE ON CDK2 GENE EXPRESSION HEPATOCELLULAR CARCINOMA CELLS AND SAAISTANT ACTION OF GAPSGF%树舌多糖GF对siRNA干扰沉默CDK2基因表达的辅助作用

    Institute of Scientific and Technical Information of China (English)

    于水澜; 于英君; 张淑香; 宋高臣

    2014-01-01

    目的:探讨树舌多糖GF辅助siRNA干扰沉默CDK2基因表达的作用.方法:本实验采用人肝癌细胞SMMC7721为研究对象,将中药树舌多糖GF2.5μg·mL-1与siRNA干扰序列191联合应用,采用Real-time PCR方法检测CDK2基因mRNA水平表达情况.结果:树舌多糖GF2.5μg·mL-1与191序列合用比单纯应用191序列抑制率提高3%.结论:树舌多糖GF2.5μg·mL-1与191序列合用比单纯应用191序列抑制率提高3%,表明树舌多糖GF对RNAi技术沉寂肝癌CDK2基因有一定的辅助作用.

  4. Demonstration of a functional requirement for the carbamate nitrogen of ribulosebisphosphate carboxylase/oxygenase by chemical rescue

    International Nuclear Information System (INIS)

    Ribulosebisphosphate carboxylase/oxygenase is reversibly activated by the reaction of Co2 with a specific lysyl residue to form a carbamate that coordinates an essential Mg2+ cation. Surprisingly, the Lys191→Cys mutant protein, in the presence of Co2 and Mg2+ exhibits tight binding of the reaction intermediate analogue 2-carboxyarabinitol bisphosphate a property normally equated with effective coordination of the Mg2+ by the carbamate. Catalytic ineptness of the Cys191 mutant protein, despite its ability to coordinate Mg2+ properly, might be due to the absence of the carbamate nitrogen. To investigate this possibility, the authors have evaluated the ability of exogenous amines to restore catalytic activity to the mutant protein. Significantly, the Cys191 protein manifests ribulose bisphosphate dependent fixation of 14CO2 when incubated with aminomethanewsulfonate but not ethanesulfonate. This novel activity reflects a Km value for ribulose bisphosphate which is not markedly perturbed relative to wild-type enzyme, a Km for Mg2+ which is in fact decreased 10-fold, and rate saturation with respect to aminomethanesulfonate. Chromatographic and spectrophotometric analyses reveal the product of CO2 fixation to be D-3-phosphoglycerate while turnover of [1-3H]ribulose bisphosphate into [3H]phosphoglycolate confirms oxygenase activity. The authors conclude that aminomethanesulfonate restored ribulosebisphosphate carboxylase/oxygenase activities to the Cys191 mutant protein by providing a nitrogenous function which satisfies a catalytic demand normally met by the carbamate nitrogen of Lys191

  5. Isolation and characterization of bacteria with antibacterial properties from Nile tilapia (Oreochromis niloticus).

    Science.gov (United States)

    Etyemez, Miray; Balcazar, Jose Luis

    2016-04-01

    One hundred and twenty bacterial isolates were obtained from the intestinal mucus of Nile tilapia (Oreochromis niloticus) and screened for antagonistic activity and adherence abilities. Based on in vitro antagonism against two pathogens (Streptococcus iniae and Edwardsiella piscicida), five isolates were selected and identified by 16S rRNA gene sequence analysis. All antagonistic isolates were affiliated to the genus Bacillus, which showed inhibitory activity against S. iniae. Only the isolate B191 (closely related to Bacillus mojavensis) inhibited the growth of both pathogens. Moreover, isolate B191 adhered significantly better to fish intestinal mucus than other antagonistic isolates. According to our results, these bacterial isolates, particularly isolate B191, should be further studied to explore their probiotic effects under in vivo conditions. PMID:27033910

  6. 补肝肾增发灵粉剂胶囊治疗肝肾不足型脱发的临床疗效观察%Clinical observation on treating alopecia with the Zengfa Ling capsule

    Institute of Scientific and Technical Information of China (English)

    陈本善

    2014-01-01

    To investigate clinical effects of Zengfa Ling capsule on alopecia. Methods:191 patients were given Zengfa Ling capsule for 3 months. Results:188 patients were better, while 3 patients were invalid. Conclusion:Zengfa Ling shows great effects on alopecia.%目的:通过临床实践交流补肝肾增发灵粉剂胶囊治疗肝肾不足型脱发的临床治疗效果。方法:选取191例肝肾不足型脱发患者服用补肝肾增发灵粉剂胶囊治疗3个月。结果:治疗观察191例患者,188例有治疗效果,3例无效。结论:增发丸治疗脱发临床效果显著。

  7. Dicty_cDB: AFH148 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available toma infestans cathepsin L-lik... 191 1e-47 EF670319_1( EF670319 |pid:none) Artemia persimilis cathepsin... AF147207_1( AF147207 |pid:none) Artemia franciscana cathepsin L-li... 193 2e-48 AY795054_1( AY795054 |pid:none) Artemia...L (CAT-L1)... 191 8e-48 ( P13277 ) RecName: Full=Digestive cysteine proteinase 1; ... 191 1e-47 AY363263_1( AY363263 |pid:none) Tria...N S58669 |S58669.1 Entamoeba histolytica cysteine proteinase precursor (ACP1) gene, partial cds. 54 2e-06 2 ...c, DNA sequence. 40 0.019 2 AF326781 |AF326781.1 Triticum monococcum actin (ACT-1) gene, partial cds; putative chrom

  8. 产铁载体PGPR菌筛选及其对病原菌的拮抗作用%Screening of siderophore-producing PGPR bacteria and their antagonism against the pathogens

    Institute of Scientific and Technical Information of China (English)

    荣良燕; 姚拓; 赵桂琴; 柴强; 席琳乔; 王小利

    2011-01-01

    By adopting improved CAS methods, the strains antagonistic against plant pathogens were firstly screened from the 16 PGPR strains, and the antagonistic experiments were then conducted by using 5 PGPR strains to 3 types of plant pathogens using plate cultivation.The results showed that LHS11 had the best inhibitory effects on Fusarium oxysporum f.sp.cucumerinum and F.oxysporum f.sp.niveum, vith the inhibition ratio over 80%; the inhibition ratio of 191 against F.oxysporum f.sp.cucumerinum was 74%.The inhibitory effects of LHS11 and 191 on Rhizoctonia solani were similar ( 64% and 65%, respectively).Both 191 and LHS11 could be used as PGPR biocontrol agents with good inhibitory effects and high application potential.%采用改进的CAS定性、定量方法,从16株PGPR菌株中初步筛选出具有抗病原真菌作用的菌株,再利用平板对峙法将筛选出的5株PGPR菌与3种病原真菌进行拮抗试验.结果表明,LHSll对黄瓜枯萎病菌(Fusarium oxysporUTh f.sp.cucumerinum),西瓜枯萎病菌(Fusarium oxysporum f.sp.niveum)的抑制效果最好,抑菌率达到80%以上;其次是191对黄瓜枯萎病菌,抑菌率为74%,LHSll、191对立枯丝核菌(Rhizoctonia solani)的抑制效果相近,抑菌率分别为64%和65%.191和LHSll是抑菌效果较好的生防PGPR菌株,具有较好的应用潜力.

  9. DSC analyses of static and dynamic precipitation of an Al–Mg–Si–Cu aluminum alloy

    OpenAIRE

    Manping Liu; Zhenjie Wu; Rui Yang; Jiangtao Wei; Yingda Yu; Pål C. Skaret; Hans J. Roven

    2015-01-01

    In the present investigation, both static and dynamic precipitations of an Al–Mg–Si–Cu aluminum alloy after solid-solution treatment (SST) were comparatively analyzed using differential scanning calorimetry (DSC). Dynamic aging was performed in the SST alloy through equal channel angular pressing (ECAP) at different temperatures of room temperature, 110, 170, 191 and 300 °C. For comparison, static artificial aging was conducted in the SST alloy at 191 °C with two aging times of 4 and 10 h. Th...

  10. Sensitive detection of nucleic acids by PNA hybridization directed co-localization of fluorescent beads

    DEFF Research Database (Denmark)

    Shiraishi, Takehiko; Deborggraeve, Stijn; Büscher, Philippe; Nielsen, Peter E

    2011-01-01

    We have designed a pair of biotinylated peptide nucleic acid (PNA) probes targeting two sequences in 18S rRNA (from the parasite Trypanosoma brucei) at a distance of 191 nt (corresponding to maximum distance of ca. 60 nm) from each other. The PNA probes were individually bound to (strept)avidin-c......We have designed a pair of biotinylated peptide nucleic acid (PNA) probes targeting two sequences in 18S rRNA (from the parasite Trypanosoma brucei) at a distance of 191 nt (corresponding to maximum distance of ca. 60 nm) from each other. The PNA probes were individually bound to (strept...

  11. Lowering of phytic acid content by enhancement of phytase and acid phosphatase activities during sunflower germination

    OpenAIRE

    Juliana da Silva Agostini; Rosicler Balduíno Nogueira; Elza Iouko Ida

    2010-01-01

    The objective of this work was to investigate the germination of hybrid sunflowers BRS191 and C11 as a means of lowering phytic acid (PA) content by enhancing the activity of endogenous phytase and acid phosphatase. The concentration of PA in hybrid sunflower achenes varied from 2.16 to 2.83g/100g of sample (p < 0.05). The phytase and acid phosphatase activities of sunflowers BRS191 and C11 were the highest on the 4th and 5th days of germination, respectively, with the release of the phosphor...

  12. AcEST: DK952763 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TST38A01NGRL0014_P19 595 Adiantum capillus-veneris mRNA. clone: TST38A01NGRL0014_P19. 5' end seq ... ry: 6 RAGKSALLRALVGRPYVDLYTHTQEEQYSVHVVEPIGGSKKTLILREIS MDLVPVLLTKK 185 +AGKS+LL + + Y D+Y+ T + + V +E GG + ... ery: 9 AGKSALLRALVGRPYVDLYTHTQEEQYSVHVVEPIGGSKKTLILREIS MDLVPVLLTKKD 188 AGKSALL + + RP+ LY T + + +V+ VE GG ... ery: 12 GKSALLRALVGRPYVDLYTHTQEEQYSVHVVEPIGGSKKTLILREIS MDLVPVLLTKKDA 191 GKS+LL A +GR + + Y+ T + + +V+ +E ... ery: 12 GKSALLRALVGRPYVDLYTHTQEEQYSVHVVEPIGGSKKTLILREIS MDLVPVLLTKKDA 191 GKSA L+A +GR T Q Y++ V+ + G +K LI ...

  13. Drug: D00579 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00579 Drug Foscarnet sodium (USAN/INN); Foscavir (TN) CO5P. 3Na 191.9176 191.9508 ...d derivatives J05AD01 Foscarnet D00579 Foscarnet sodium (USAN/INN) USP drug classification [BR:br08302] Anti...virals Anti-cytomegalovirus (CMV) Agents Foscarnet D00579 Foscarnet sodium (USAN/INN) Antiherpetic Agents Foscarnet D00579 Foscar... Anti-CMV agent DNA polymerase inhibitor Phosphonic acid derivatives Foscarnet [ATC:J05AD01] D00579 Foscarne...05 ANTIVIRALS FOR SYSTEMIC USE J05A DIRECT ACTING ANTIVIRALS J05AD Phosphonic aci

  14. Frequency and characterisation of anoctamin 5 mutations in a cohort of Italian limb-girdle muscular dystrophy patients

    OpenAIRE

    Magri, Francesca; Bo, Roberto Del; D’Angelo, Maria Grazia; Sciacco, Monica; Gandossini, Sandra; Govoni, Alessandra; Napoli, Laura; Ciscato, Patrizia; Fortunato, Francesco; Brighina, Erika; Bonato, Sara; Bordoni, Andreina; Lucchini, Valeria; Corti, Stefania; Moggio, Maurizio

    2012-01-01

    Limb-girdle muscular dystrophy (LGMD) 2L, caused by mutations in the anoctamin 5 (ANO5) gene, is the third most common LGMD in Northern and Central Europe, where the c.191dupA mutation causes the majority of cases. We evaluated data from 228 Italian LGMD patients to determine the prevalence of LGMD2L and the c.191dupA mutation, and to describe the clinical, muscle biopsy, and magnetic resonance imaging findings in these patients. Forty-three patients who lacked molecular diagnosis were studie...

  15. AcEST: DK949307 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TST38A01NGRL0005_K06 724 Adiantum capillus-veneris mRNA. clone: TST38A01NGRL0005_K06. 5' end seq ... |Q946F7_ARGSA ASCAB9-B (Fragment) OS=Argyroxiphium sand ... 191 4e-47 tr|Q946F6|Q946F6_ARGSA ASCAB9-C (Frag ... ment) OS=Argyroxiphium sand ... 191 4e-47 tr|Q946F5|Q946F5_9ASTR ASCAB9-C (Frag ...

  16. Dicty_cDB: CHG749 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available ngth of query: 191 length of database: 80,480,566 effective HSP length: 17 effective... length of query: 174 effective length of database: 78,821,179 effective search space: 13714885146 effective...6986 Number of sequences better than 10.0: 0 length of query: 191 length of database: Z,915,520,312 effective HSP length: 22 effectiv...e length of query: 169 effective length of database: Z,063,426,916 effective... search space: 7108719148804 effective search space used: 7108719148804 T: 0 A: 0 X1: 6

  17. Problems Related to Use of Some Terms in System Reliability Analysis

    Directory of Open Access Journals (Sweden)

    Nadezda Hanusova

    2004-01-01

    Full Text Available The paper deals with problems of using dependability terms, defined in actual standard STN IEC 50 (191: International electrotechnical dictionary, chap. 191: Dependability and quality of service (1993, in a technical systems dependability analysis. The goal of the paper is to find a relation between terms introduced in the mentioned standard and used in the technical systems dependability analysis and rules and practices used in a system analysis of the system theory. Description of a part of the system life cycle related to reliability is used as a starting point. The part of a system life cycle is described by the state diagram and reliability relevant therms are assigned.

  18. On line nuclear orientation of Au isotopes at KOOL

    International Nuclear Information System (INIS)

    The low temperature nuclear orientation facility KOOL was used for a systematical study of the very neutron-deficient Au isotopes where the on-line technique is compulsory due to the short lifetimes involved. The measurement of the magnetic moment of the 4.6 min 189Au 11/2- isomer, a preliminary result on the same state in tsub(1/2) = 0.9 sec 191Au and the moment value of the tsub(1/2) = 10.7 min 186Au 3- ground state is reported. Several spins and mixing ratios in 189Pt, 186Pt and 191Au have been determined as well

  19. The biokinetics of alpha-particle emitting radiopharmaceuticals

    International Nuclear Information System (INIS)

    The past two decades have seen wide interest in the application of alpha-particle emitting radionuclides for targeted endoradiotherapy and a large number of compounds labeled with 211At (T1/2 7.21 h), 212Bi (T1/2 1 h) or 213Bi (T1/2 0.78 h) have been studied. Knowledge of the biokinetic behaviour of such agents is important both for their optimal clinical exploitation and for general radiological protection purposes. Animal studies of the distribution and retention of 211At compounds, including ionic astatide, substituted aromatic compounds and labelled monoclonal antibodies, have provided new information on the biochemistry of astatine. With respect the thyroid gland the uptake of the astatide ion has been shown to be very much lower than that of the iodide ion. Less information is available for 212Bi-labelled radiopharmaceuticals. The available data for both 211At and 212Bi radiopharmaceuticals are reviewed. Cautious generic biokinetic models for inorganic and simple organic compounds of 211At and 212Bi; for [211At]-, and [212Bi]-biphosphonates and for [211At]-, and [212Bi]-monoclonal antibodies, are proposed for use in general radiological protection when compound-specific data are not available. (orig.)

  20. The radiolabeled monoclonal antibodies in immunoscintigraphy and radioimmunotherapy: current state and perspectives

    International Nuclear Information System (INIS)

    The antibodies can be satisfactorily labelled with technitium-99 m or indium-111 for tumor immunoscintigraphy. The immunoscintigraphy is not useful for the primary tumor diagnosis. It can be useful for the diagnosis of the some cancer extension and for recurrent tumor visualization. The immunoscintigraphy is widely competed with Positron Emission Tomography (PET) which gives accurate results. In the future the immunoscintigraphy, in pre-therapeutic stage, contribute to the estimation of the dose delivered to the tumor and to normal organs for adopting or not a radioimmunotherapy. The antibodies can also be labeled with Iodine-131 for an application in radioimmunotherapy (RIT). The RIT is efficient in the non-Hodgkin's lymphoma treatment because of their great radiosensitivity. Until now the results have been very modest in solid tumor treatment but methodological and biotechnological progresses have to improve the efficiency especially for the small tumors. In the future iodine-131 which requires the confinement (very expensive) of patients will be substituted by yttrium-90 beta emitter, more energetic than iodine-131 and can be injected in walking case. In the long term, the alpha emitter radionuclides (astatine-211 or bismuth-213) can be used for hematologic cancer treatment. In conclusion the future of radiolabeled monoclonal antibodies is essentially therapeutic. The radioimmunotherapy associated to the chemotherapy give promising perspectives for the radiosensitive cancer treatment and in general small solid tumor treatment (F.M.)

  1. Biological toxicity of intracellular radionuclide decay. Part of a coordinated programme on radiation biology of Auger emitters and their therapeutic applications

    International Nuclear Information System (INIS)

    Internal radiotherapy should be performed with short-lived radionuclides which emit high LET radiation and short ranged radiation, and accumulated within cancers. Based on these considerations, several radionuclides (tritium, copper-64, gallium-67, iodine-123, iodine 125, iodine-131 and astatine-211) were chosen and their toxicity was assessed using cell division in mammalian cultured cells as a criterion. It was apparent that the toxic effects obtained with 125I greatly exceeded those observed in cells treated with any other radionuclides. The possible hypotheses to explain the excessive radiosensitivity of 125I were discussed in relation to microdosimetry calculation. It was also found that the division delay induced by radionuclide decay is primarily due to damage to the cell nucleus but not to the plasma membrane. The key problem remains the development of agents which can serve as carriers for radionuclide accumulation within tumors. Although several promising approaches (Synkavit, tamoxifen, iododeoxyuridine, antibodies, liposomes) were investigated, only 125I-labelled Synkavit would be desirable for clinical application

  2. Study of Neutron-Deficient $^{202-205}$Fr Isotopes with Collinear Resonance Ionization Spectroscopy

    CERN Document Server

    De Schepper, Stijn; Cocolios, Thomas; Budincevic, Ivan

    The scope of this master’s thesis is the study of neutron-deficient $^{202−205}$Fr isotopes. These isotopes are inside the neutron-deficient lead region, a region that has shown evidence of shape coexistence. For this thesis, this discussion is limited to the phenomenon where a low lying excited state has a different shape than the ground state. Shape coexistence is caused by intruder states. These are single-particle Shell Model states that are perturbed in energy due to the interaction with a deformed core. In the neutron-deficient lead region the main proton intruder orbit is the 3s$_{1/2}$orbit. When going towards more neutron-deficient isotopes, deformation increases. The $\\pi3s_{1/2}$orbit will rise in energy and will eventually become the ground state in odd- A bismuth (Z=83) isotopes. It is also observed in odd-A astatine (Z=85) isotopes, already in less neutron-deficient nuclei. The same phenomenon is expected to be present francium (Z=87) isotopes already at $^{199}$Fr. Although it is currently ...

  3. The biokinetics of alpha-particle emitting radiopharmaceuticals

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, D.M. [School of Chemistry, Cardiff Univ., Cardiff (United Kingdom); Duffield, J.R. [Faculty of Applied Sciences, Univ. of the West of England, Bristol (United Kingdom)

    2005-07-01

    The past two decades have seen wide interest in the application of alpha-particle emitting radionuclides for targeted endoradiotherapy and a large number of compounds labeled with {sup 211}At (T{sup 1}/{sub 2} 7.21 h), {sup 212}Bi (T{sup 1}/{sub 2} 1 h) or {sup 213}Bi (T{sup 1}/{sub 2} 0.78 h) have been studied. Knowledge of the biokinetic behaviour of such agents is important both for their optimal clinical exploitation and for general radiological protection purposes. Animal studies of the distribution and retention of {sup 211}At compounds, including ionic astatide, substituted aromatic compounds and labelled monoclonal antibodies, have provided new information on the biochemistry of astatine. With respect the thyroid gland the uptake of the astatide ion has been shown to be very much lower than that of the iodide ion. Less information is available for {sup 212}Bi-labelled radiopharmaceuticals. The available data for both {sup 211}At and {sup 212}Bi radiopharmaceuticals are reviewed. Cautious generic biokinetic models for inorganic and simple organic compounds of {sup 211}At and {sup 212}Bi; for [{sup 211}At]-, and [{sup 212}Bi]-biphosphonates and for [{sup 211}At]-, and [{sup 212}Bi]-monoclonal antibodies, are proposed for use in general radiological protection when compound-specific data are not available. (orig.)

  4. Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

    International Nuclear Information System (INIS)

    Aim: The monoclonal antibody cetuximab, targeting the epidermal growth factor receptor (EGFR), is a promising molecular targeting agent to be used in combination with radiation for anticancer therapy. In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed. Methods: SCC cell lines were characterized and treated with cetuximab in combination with anti-CD44v6 RIT using the astatinated chimeric monoclonal antibody U36 (211At-cMAb U36). Effects on 211At-cMAb U36 uptake, internalization and cell proliferation were then assessed in SCC cells. Results: Cetuximab in combination with 211At-cMAb U36 mediated increased growth inhibition compared to RIT or cetuximab alone in two cell lines. However, cetuximab also mediated radioprotective effects compared to RIT alone in two cell lines. The radioprotective effects occurred in the cell lines in which cetuximab clearly inhibited cell growth during radiation exposure. Cetuximab treatment also influenced 211At-cMAb-U36 uptake and internalization, suggesting interactions between CD44v6 and EGFR. Conclusions: Results from this study demonstrate the vast importance of further clarifying the mechanisms of cetuximab and radiation response, and the relationship between EGFR and suitable RIT targets. This is important not only in order to avoid potential radioprotective effects, but also in order to find and utilize potential synergistic effects from these combinations.

  5. Tumor immunotargeting using innovative radionuclides.

    Science.gov (United States)

    Kraeber-Bodéré, Françoise; Rousseau, Caroline; Bodet-Milin, Caroline; Mathieu, Cédric; Guérard, François; Frampas, Eric; Carlier, Thomas; Chouin, Nicolas; Haddad, Ferid; Chatal, Jean-François; Faivre-Chauvet, Alain; Chérel, Michel; Barbet, Jacques

    2015-01-01

    This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality. PMID:25679452

  6. Tumor Immunotargeting Using Innovative Radionuclides

    Directory of Open Access Journals (Sweden)

    Françoise Kraeber-Bodéré

    2015-02-01

    Full Text Available This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as well as alpha-emitting radionuclides, including astatine-211, bismuth-213, actinium-225, and others are currently reviving hopes in cancer treatments, both in hematological diseases and solid tumors. At the same time, PET imaging, with short-lived radionuclides, such as gallium-68, fluorine-18 or copper-64, or long half-life ones, particularly iodine-124 and zirconium-89 now offers new perspectives in immuno-specific phenotype tumor imaging. New antibody analogues and pretargeting strategies have also considerably improved the performances of tumor immunotargeting and completely renewed the interest in these approaches for imaging and therapy by providing theranostics, companion diagnostics and news tools to make personalized medicine a reality.

  7. Proceedings of transuranium elements

    International Nuclear Information System (INIS)

    The identification of the first synthetic elements was established by chemical evidence. Conclusive proof of the synthesis of the first artificial element, technetium, was published in 1937 by Perrier and Segre. An essential aspect of their achievement was the prediction of the chemical properties of element 43, which had been missing from the periodic table and which was expected to have properties similar to those of manganese and rhenium. The discovery of other artificial elements, astatine and francium, was facilitated in 1939-1940 by the prediction of their chemical properties. A little more than 50 years ago, in the spring of 1940, Edwin McMillan and Philip Abelson synthesized element 93, neptunium, and confirmed its uniqueness by chemical means. On August 30, 1940, Glenn Seaborg, Arthur Wahl, and the late Joseph Kennedy began their neutron irradiations of uranium nitrate hexahydrate. A few months later they synthesized element 94, later named plutonium, by observing the alpha particles emitted from uranium oxide targets that had been bombarded with deuterons. Shortly thereafter they proved that is was the second transuranium element by establishing its unique oxidation-reduction behavior. The symposium honored the scientists and engineers whose vision and dedication led to the discovery of the transuranium elements and to the understanding of the influence of 5f electrons on their electronic structure and bonding. This volume represents a record of papers presented at the symposium

  8. Silver impregnated nanoparticles of titanium dioxide as carriers for {sup 211}At

    Energy Technology Data Exchange (ETDEWEB)

    Cedrowska, Edyta; Lyczko, Monika; Piotrowska, Agata; Bilewicz, Aleksander [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Stolarz, Anna; Trcinska, Agnieszka [Warsaw Univ. (Poland). Heavy Ion Lab.; Szkliniarz, Katarzyna [Silesia Univ. Katowice (Poland). Inst. of Physics; Was, Bogdan [Polish Academy of Science, Cracow (Poland). Inst. of Nuclear Physics

    2016-08-01

    The {sup 211}At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of {sup 211}At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes {sup 211}At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of {sup 211}At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for {sup 211}At. Ag{sup +} cations have been absorbed on the nanometer-sized TiO{sub 2} particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO{sub 2}-Ag nanoparticles were labeled with {sup 211}At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO{sub 2}/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO{sub 2}/Ag surface.

  9. Development and radiotherapeutic application of 211At-labeled radiopharmaceuticals. Progress report, March 1, 1981-February 28, 1982

    International Nuclear Information System (INIS)

    This project is concerned with developing the potential of alpha-emitting radionuclides as agents for radiotherapy. Alpha-emitters seem ideally suited for his application because their high linear energy transfer and short range permit the deposition of considerable energy in a very small volume of tissue. Unlike the beta particles of 131I which have a range of about 1 to 2 mm in tissue, 5 to 7 MeV alpha particles would traverse only a few cell diameters. Among the available alpha-emitters, 211At appears most promising for therapeutic applications because, (1) it has some chemical similarities to iodine, an element that can readily be incorporated into numerous proteins and peptides, (2) it has a half-life that is long enough to permit chemical manipulation yet short enough to minimize destruction of healthy cells due to degradation of the label over time, (3) it can be produced conveniently using a cyclotron, and (4) alpha emission is associated with 100% of its decays with no accompanying beta emission. In the past year the evaluation of an astatine-tellurium colloid as an agent for the destruction of malignant ascites has been completed. The therapeutic efficacy of 211At-tellurium colloid has been compared with that of several beta-emitting radiocolloids. Studies on the application of monoclonal antibodies as carriers for selective delineation and destruction of malignant cell populations have also been initiated

  10. Nuclear and chemical data for life sciences

    International Nuclear Information System (INIS)

    Use of reactor produced radionuclides is popular in life sciences. However, cyclotron production of proton rich radionuclides are being more focused in recent times. These radionuclides have already gained attention in various fields, including life sciences, provided they are obtained in pure form. This article is a representative brief of our contributions in generating nuclear data for the production of proton rich radionuclides of terbium, astatine, technetium, ruthenium, cadmium, niobium, zirconium, rhenium, etc., which may have application in clinical, biological, agriculture studies or in basic research. The chemical data required to separate the product isotopes from the corresponding target matrix have been presented along with a few propositions of radiopharmaceuticals. It also emphasizes on the development of simple empirical technique, based on the nuclear reaction model analysis, to generate reliable nuclear data for the estimation of yield and angular distribution of emitted neutrons and light charged particles from light as well as heavy ion induced reactions on thick stopping targets. These data bear utmost important in radiation dosimetry. (author)

  11. Studies of Stable Octupole Deformations in the Radium Region

    CERN Multimedia

    2002-01-01

    The purpose of the present project is to locate and identify states in the atomic nuclei possessing stable pearshaped octupole deformation. Such states, formally related to the structures known in molecular physics, manifest themselves as families of parity doublets in odd nuclei.\\\\ \\\\ The best possibilities for observing stable octupole deformations are offered in the Ra-region. Both theoretical calculations and experimental indications support such expectations. Such indications are the non-observation of two-phonon octupole vibrational states in the ISOLDE studies of the even-even radium nuclei, and the reversed sign of the decoupling factor of the ground state band in |2|2|5Ra observed in the single-neutron transfer reactions. In order to establish the predicted strong E1 and E3-transitions between the parity doublets in odd nuclei with stable octupole deformations it is proposed to study conversion electrons in odd-mass francium radium and radon isotopes following the @b-decay of francium and astatine. \\...

  12. Effect of cetuximab in combination with alpha-radioimmunotherapy in cultured squamous cell carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Nestor, Marika, E-mail: marika.nestor@bms.uu.s [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden); Sundstroem, Magnus [Unit of Molecular Pathology, Department of Genetics and Pathology, Uppsala University (Sweden); Anniko, Matti [Unit of Otolaryngology and Head and Neck Surgery, Department of Surgical Sciences, Uppsala University, S-751 85 Uppsala (Sweden); Tolmachev, Vladimir [Unit of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, S-751 85 Uppsala (Sweden)

    2011-01-15

    Aim: The monoclonal antibody cetuximab, targeting the epidermal growth factor receptor (EGFR), is a promising molecular targeting agent to be used in combination with radiation for anticancer therapy. In this study, effects of cetuximab in combination with alpha-emitting radioimmunotherapy (RIT) in a panel of cultured human squamous cell carcinomas (SCCs) were assessed. Methods: SCC cell lines were characterized and treated with cetuximab in combination with anti-CD44v6 RIT using the astatinated chimeric monoclonal antibody U36 ({sup 211}At-cMAb U36). Effects on {sup 211}At-cMAb U36 uptake, internalization and cell proliferation were then assessed in SCC cells. Results: Cetuximab in combination with {sup 211}At-cMAb U36 mediated increased growth inhibition compared to RIT or cetuximab alone in two cell lines. However, cetuximab also mediated radioprotective effects compared to RIT alone in two cell lines. The radioprotective effects occurred in the cell lines in which cetuximab clearly inhibited cell growth during radiation exposure. Cetuximab treatment also influenced {sup 211}At-cMAb-U36 uptake and internalization, suggesting interactions between CD44v6 and EGFR. Conclusions: Results from this study demonstrate the vast importance of further clarifying the mechanisms of cetuximab and radiation response, and the relationship between EGFR and suitable RIT targets. This is important not only in order to avoid potential radioprotective effects, but also in order to find and utilize potential synergistic effects from these combinations.

  13. Alpha particle emitters in medicine

    International Nuclear Information System (INIS)

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 (211At) and natural bismuth-212 (212Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 (223Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs

  14. Preparation of 211At-labeled humanized anti-Tac using 211At produced in disposable internal and external bismuth targets

    International Nuclear Information System (INIS)

    These studies describe the production and purification of 211At as well as the procedure for labeling humanized anti-Tac, the antibody to the α-chain of the IL-2 receptor (IL-2Rα), which has been shown to be a useful target for immunotherapy. The optimized protocol combines the advantages of the two-stage dry distillation procedure with the astatination of trialkylstannyl substances as labeling compounds for proteins. The 211At was produced by bombarding either an external or a recently developed disposable internal bismuth target with α-particles from a Cyclotron Corporation CS-30 cyclotron. The 211At was found to contain less than 0.01% 210At. The production rate for the external target was 0.15 mCi ± 0.056 μA-1 h-1 (n = 9) (5.55 MBq μA-1 h-1). The production rate for the internal target was 0.44 ± 0.14 mCi μA-1 h-1 (n = 16) (16.28 MBq μA-1 h-1)

  15. Andrej Voznesenskij - ot paraboly k krugu

    Czech Academy of Sciences Publication Activity Database

    Ulbrechtová, Helena

    Brno: Masarykova univerzita v Brně, 2006 - (Dohnal, J.), s. 191-198 ISBN 80-210-4179-X. [Problémy poetiky. Brno (CZ), 20.10.2006-21.10.2006] Institutional research plan: CEZ:AV0Z90920516 Keywords : Russian Poetry Subject RIV: AJ - Letters, Mass-media, Audiovision

  16. On equivalent roughness of mobile bed at high shear stress

    Czech Academy of Sciences Publication Activity Database

    Matoušek, Václav; Krupička, Jan

    2009-01-01

    Roč. 57, č. 3 (2009), s. 191-199. ISSN 0042-790X R&D Projects: GA ČR GA103/06/0428 Institutional research plan: CEZ:AV0Z20600510 Keywords : bed shear * experiment * hydraulic transport * sediment transport Subject RIV: BK - Fluid Dynamics Impact factor: 1.000, year: 2009

  17. Synthesis, structural investigation and kinetic studies of uranyl(VI) unsymmetrical Schiff base complexes

    Czech Academy of Sciences Publication Activity Database

    Asadi, Z.; Asadi, M.; Zeinali, A.; Ranjkeshshorkaei, M.; Fejfarová, Karla; Eigner, Václav; Dušek, Michal; Dehnokhalaji, A.

    2014-01-01

    Roč. 126, č. 6 (2014), s. 1673-1683. ISSN 0974-3626 R&D Projects: GA ČR(CZ) GAP204/11/0809 Institutional support: RVO:68378271 Keywords : uranyl schiff base complexes * kinetic study * kinetics of thermal decomposition * X-ray crystallography * cyclic voltammetry Subject RIV: CA - Inorganic Chemistry Impact factor: 1.191, year: 2014

  18. Bolestná Panna Marie, kolem 1510

    Czech Academy of Sciences Publication Activity Database

    Dáňová, Helena; Gubíková, R.

    Chomutov: Oblastní muzeum v Chomutově, 2014 - (Dáňová, H.; Gubíková, R.), s. 191-195 ISBN 978-80-87898-07-9 Institutional support: RVO:68378033 Keywords : Our Lady of Sorrows * Saxony * Freiberg Subject RIV: AL - Art, Architecture, Cultural Heritage

  19. Regulation of mTORC1 signaling by Src kinase activity is Akt1-independent in RSV-transformed cells

    Czech Academy of Sciences Publication Activity Database

    Vojtěchová, Martina; Turečková, Jolana; Kučerová, Dana; Šloncová, Eva; Vachtenheim, J.; Tuháčková, Zdena

    2008-01-01

    Roč. 10, č. 2 (2008), s. 99-107. ISSN 1522-8002 R&D Projects: GA ČR GA301/04/0550 Institutional research plan: CEZ:AV0Z50520514 Keywords : Akt/PKB * mTORC1 signaling pathway * Src Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 5.191, year: 2008

  20. VizieR Online Data Catalog: HK photometry in an UCHII region near Sh2-217 (Brand+, 2011)

    Science.gov (United States)

    Brand, J.; Massi, F.; Zavagno, A.; Deharveng, L.; Lefloch, B.

    2010-11-01

    Coordinates and photometric parameters (magnitudes and colours) are presented of the stars located in a molecular condensation on the SW-border of the Galactic HII region Sh2-217. The data were obtained on January 4, 2004 with the 3.58-m Telescopio Nazionale Galileo (TNG; La Palma, Canary Islands, Spain). Near-infrared observations were carried out through H and K' broad-band filters with the camera NICS. The image scale is 0.25arcsec/pixel, yielding a field of view of about 4.2'x4.2'. Observing strategy and exposure times are described in Deharveng et al. (2006A&A...458..191D), the only difference being that the dithering sequence for the H-band images was the same as adopted for K'. The data reduction steps adopted are outlined in Deharveng et al. (2006A&A...458..191D). Aperture photometry was done using the DAOPHOT package in IRAF. We followed the same procedure described in Deharveng et al. (2006A&A...458..191D) to obtain aperture photometry, after which PSF-fitting photometry was performed. Although the seeing was good (position on the image of a sample of stars and fitting those positions to the equatorial coordinates given by Deharveng et al. (2006A&A...458..191D), using tasks of STSDAS/IRAF. The typical accuracy of this procedure is of the order of 1". (1 data file).

  1. 40 CFR 194.26 - Expert judgment.

    Science.gov (United States)

    2010-07-01

    ... CFR PART 191 DISPOSAL REGULATIONS Compliance Certification and Re-certification General Requirements...: (i) Individuals who are members of the team of investigators requesting the judgment or the team of... organizational level, a supervisory role or who are supervised by those who will utilize the judgment were...

  2. Parents‘ and peers‘ influence on norms and norm-breaking behavior of Slovak adolescent boys and girls

    Czech Academy of Sciences Publication Activity Database

    Ruiselová, Z.; Urbánek, Tomáš

    2008-01-01

    Roč. 50, č. 2 (2008), s. 191-200. ISSN 0039-3320 Institutional research plan: CEZ:AV0Z70250504 Keywords : adolescents * norm-breaking behavior * structural equations model Subject RIV: AN - Psychology Impact factor: 0.258, year: 2008

  3. 77 FR 45663 - James William Eisenberg, M.D.; Decision and Order

    Science.gov (United States)

    2012-08-01

    ...-92.) Respondent prescribed oxycodone for her severe lower back pain. (Tr. 191.) Respondent testified.... for 120 tablets of oxycodone 30 milligrams because she had back pain and ``she felt was in need of... for a legitimate medical purpose in the course of his practice, explaining that M.F.'s back pain...

  4. Quantitative phase analysis of model painting layers : A comparasion of X-ray micro-diffraction with conventional transmission and reflection geometries

    Czech Academy of Sciences Publication Activity Database

    Bezdička, Petr; Kotulanová, Eva; Klementová, Mariana

    2009-01-01

    Roč. 65, suppl - abstracts (2009), s. 191. ISSN 0108-7673. [European Crystalographic Meeting /25./. 16.08.2009-21.08.2009, Istanbul] Institutional research plan: CEZ:AV0Z40320502 Keywords : micro-diffraction * quantitative phase analysis * art-works Subject RIV: CA - Inorganic Chemistry

  5. The Effects of Laboratory-Based and Field-Based Practicum Experience on Pre-Service Teachers' Self-Efficacy

    Science.gov (United States)

    Gurvitch, Rachel; Metzler, Michael W.

    2009-01-01

    A well defined line of research has been conducted on the role of self-efficacy (Bandura, A. (1977). Self-efficacy: toward a unifying theory of behavioral change. "Psychological Review", 84, 191-215.) in teaching and learning environments. The purpose of this study was to examine the effect of Laboratory-Based (LB) and Field-Based (FB) practicum…

  6. Do GST Polymorphisms Modulate the Frequency of Chromosomal Aberrations in Healthy Subjects?

    Czech Academy of Sciences Publication Activity Database

    Vodička, Pavel; Naccarati, Alessio; Vodičková, Ludmila; Poláková, Veronika; Dušinská, M.; Mušák, L.; Halasová, E.; Susová, S.; Souček, P.; Hemminki, K.

    2009-01-01

    Roč. 117, č. 9 (2009), A384-A385. ISSN 0091-6765 Institutional research plan: CEZ:AV0Z50390512 Keywords : DNA-repair genes * individual susceptibility * biomarkers Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 6.191, year: 2009

  7. Perceived Physical Appearance Mediates the Rumination and Bulimic Symptom Link in Adolescent Girls

    Science.gov (United States)

    Holm-Denoma, Jill M.; Hankin, Benjamin L.

    2010-01-01

    The prospective relationship between initial rumination and subsequent bulimic symptoms, and vice versa, was examined, and possible mediators were tested in a community sample of 191 adolescent girls (M age = 14.5) at 3 different assessment time points. Path analyses indicated that Time 1 rumination predicted Time 3 bulimic symptoms, and vice…

  8. Rozbor textilních fragmentů z meče a šavle z pohřebiště Olomouc-Nemilany

    Czech Academy of Sciences Publication Activity Database

    Březinová, Helena

    Brno : Masarykova univerzita, 2014 - (Přichystalová, R.; Kalábek, M.), s. 191-197 ISBN 978-80-210-7521-4. - (Spisy Masarykovy univerzity v Brně, Filozofická fakulta. 424) Institutional support: RVO:67985912 Keywords : Olomouc - Nemilany * textile fragments * textile -technological research Subject RIV: AC - Archeology, Anthropology, Ethnology

  9. High School Timetabling: Modeling and solving a large number of cases in Denmark

    DEFF Research Database (Denmark)

    Sørensen, Matias; Stidsen, Thomas Riis

    2012-01-01

    high school administration (available only for Danish high schools), which includes an embedded application for creating a weekly timetable. Currently, 230 high schools are customers of Lectio, and 191 have bought access to the timetabling software. This constitutes the majority of high schools in...

  10. Structural and mutational analysis of band 7 proteins in the cyanobacterium Synechocystis sp. strain PCC 6803

    Czech Academy of Sciences Publication Activity Database

    Boehm, M.; Nield, J.; Zhang, P.; Aro, E.-M.; Komenda, Josef; Nixon, P. J.

    2009-01-01

    Roč. 191, č. 20 (2009), s. 6425-6435. ISSN 0021-9193 R&D Projects: GA AV ČR IAA400200801 Institutional research plan: CEZ:AV0Z50200510 Keywords : BLUE NATIVE ELECTROPHORESIS * PHOTOSYSTEM-II COMPLEX * COLI PLASMA-MEMBRANE Subject RIV: EE - Microbiology, Virology Impact factor: 3.940, year: 2009

  11. Experiment list: SRX170375 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Diagnosis=Normal 13813513,90.4,3.3,191 GSM971948: HEK293 Brd4 ChIPSeq; Homo sapiens; ChIP-Seq source_name=HEK293..., Brd4 ChIP || cell line=HEK293 || chip antibody=anti-FLAG M2 affinity gel || antibody vendor=Sigma-Aldr

  12. Suárez on the Metaphysics and Epistemology of Universals

    Czech Academy of Sciences Publication Activity Database

    Heider, Daniel

    Leiden: Brill, 2014 - (Salas, V.), s. 164-191. (Brill's Companions to the Christian Tradition. 38). ISBN 978-90-04-28158-5 Institutional support: RVO:67985955 Keywords : Suárez * Scotus * Fonseca * common nature * universals * formal unity * universal unity * abstraction * logical intention Subject RIV: AA - Philosophy ; Religion

  13. An introduction to the mechanics of performance assessment using examples of calculations done for the Waste Isolation Pilot Plant between 1990 and 1992. Revision

    Energy Technology Data Exchange (ETDEWEB)

    Rechard, R.P.

    1996-06-01

    This document provides an overview of the processes used to access the performance of the Waste Isolation Pilot Plant (WIPP). The quantitative metrics used in the performance-assessment (PA) process are those put forward in the Environmental Protection Agency`s Environmental Standards for the Management and Disposal of Spent Nuclear Fuel, HIgh-LEvel and transuranic radioactive Wastes (40 CFR 191).

  14. AcEST: DK953349 [AcEST

    Lifescience Database Archive (English)

    Full Text Available TST39A01NGRL0017_I15 588 Adiantum capillus-veneris mRNA. clone: TST39A01NGRL0017_I15. 5' end seq ... IAGRHTPGTFTNQLQTSFSEPRLLILTDP 134 Query: 418 RTDHQPIKEA ALGNIPIIAFCDTDSPMRHVDIGIPANNKGKHSIGCLFWMLARMVLQ 588 ... RTDHQPIKEA ALGNIP IAFCDTDSPMR+VDIGIPANNKGKHSIGCLFW+LARMVLQ Sbj ... ct: 135 RTDHQPIKEA ALGNIPTIAFCDTDSPMRYVDIGIPANNKGKHSIGCLFWLLARMVLQ 191 ... IAGRHTPGTFTNQLQTSFSEPRLL 125 Query: 403 ILTDPRTDHQPIKEA ALGNIPIIAFCDTDSPMRHVDIGIPANNKGKHSIGCLFWMLARMV 582 I ...

  15. Palaeomagnetism in the Sines massif (SW Iberia) revisited: evidences for Late Cretaceous hydrothermal alteration and associated partial remagnetization

    Czech Academy of Sciences Publication Activity Database

    Ribeiro, P.; Silva, P. F.; Moita, P.; Kratinová, Zuzana; Marques, F. O.; Henry, B.

    2013-01-01

    Roč. 195, č. 1 (2013), s. 176-191. ISSN 0956-540X Grant ostatní: FCT(PT) PTDC/CTE-GIX/098696/2008 Institutional support: RVO:67985530 Keywords : magnetic fabrics and anisotropy * magnetic mineralogy and petrology * palaeomagnetism applied to tectonics Subject RIV: DE - Earth Magnetism, Geodesy, Geography Impact factor: 2.724, year: 2013

  16. Which Way Did the Bicycle Go?...and Other Intriguing Mathematical Mysteries. Dolciani Mathematical Expositions Series of the Mathematical Association of America, No. 18.

    Science.gov (United States)

    Konhauser, Joseph D. E.; And Others

    This book provides a collection of 191 mathematical problems aimed at the advanced high school student level and above. Problems cover general mathematical areas including plane geometry, three-dimensional geometry, number theory, algebra, combinatorics and graph theory, and a number of miscellaneous questions that combine mathematical…

  17. Vnímání plné předpokladů

    Czech Academy of Sciences Publication Activity Database

    Šikl, Radovan; Šimeček, Michal

    Brno: Psychologický ústav AV ČR, 2006, s. 191-196. [Kognice 2006. Praha (CZ), 06.10.2006-07.10.2006] Institutional research plan: CEZ:AV0Z70250504 Keywords : Visual perception * constraints in perception * minimum principle and likelihood principle Subject RIV: AN - Psychology

  18. File list: ALL.Lng.05.AllAg.Fetal_lung [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Lng.05.AllAg.Fetal_lung hg19 All antigens Lung Fetal lung SRX031381,SRX031423,S...191,SRX055187,SRX055198,SRX031384,SRX041015,SRX056806,SRX056804,SRX056805 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Lng.05.AllAg.Fetal_lung.bed ...

  19. Dipyridamole Body Surface Potential Mapping: Noninvasive Differentiation of Syndrome X from Coronary Artery Disease

    Czech Academy of Sciences Publication Activity Database

    Boudík, F.; Anger, Z.; Aschermann, M.; Vojáček, J.; Tomečková, Marie

    2002-01-01

    Roč. 35, č. 3 (2002), s. 181-191. ISSN 0022-0736 R&D Projects: GA MZd IZ4038 Keywords : body surface potential mapping * dipyridamole * coronary artery disease * syndrome X Subject RIV: BD - Theory of Information Impact factor: 0.599, year: 2002

  20. 27 CFR 41.194 - Articles of partnership or association.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Articles of partnership or... AND TUBES, AND PROCESSED TOBACCO Tobacco Products Importers § 41.194 Articles of partnership or..., must furnish with its application for permit required by § 41.191 a true copy of the articles...

  1. Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85

    Czech Academy of Sciences Publication Activity Database

    Škerlová, Jana; Král, V.; Kachala, M.; Fábry, M.; Bumba, L.; Svergun, D. I.; Tošner, Z.; Veverka, Václav; Řezáčová, Pavlína

    2015-01-01

    Roč. 191, č. 2 (2015), s. 214-223. ISSN 1047-8477 R&D Projects: GA MŠk(CZ) LK11205; GA MŠk(CZ) LO1304 Institutional support: RVO:61388963 Keywords : CD44 * epitope mapping * monoclonal antibody * MEM-85 * NMR * SAXS Subject RIV: CE - Biochemistry Impact factor: 3.231, year: 2014

  2. Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85

    Czech Academy of Sciences Publication Activity Database

    Škerlová, Jana; Král, Vlastimil; Kachala, M.; Fábry, Milan; Bumba, Ladislav; Svergun, D.I.; Tosner, Z.; Veverka, V.; Řezáčová, Pavlína

    2015-01-01

    Roč. 191, č. 2 (2015), s. 214-223. ISSN 1047-8477 R&D Projects: GA ČR(CZ) GA15-11851S EU Projects: European Commission 264257 Institutional support: RVO:68378050 ; RVO:61388971 Keywords : CD44 * Epitope mapping * Monoclonal antibody * MEM-85 * SAXS * NMR Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.231, year: 2014

  3. Effect of high perioperative oxygen fraction on surgical site infection and pulmonary complications after abdominal surgery

    DEFF Research Database (Denmark)

    Meyhoff, Christian S; Wetterslev, Jørn; Jorgensen, Lars N;

    2009-01-01

    Disease Control and Prevention. Secondary outcomes included atelectasis, pneumonia, respiratory failure, and mortality. RESULTS: Surgical site infection occurred in 131 of 685 patients (19.1%) assigned to receive 80% oxygen vs 141 of 701 (20.1%) assigned to receive 30% oxygen (odds ratio [OR], 0.94; 95...

  4. EST Table: FS765648 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available 72 %/182 aa ref|XP_001658413.1| neuroendocrine differentiation factor [Aedes aegypti] gb|EAT40780.1| neuroendocrine... %/191 aa gnl|Amel|GB15107-PA 10/09/10 68 %/187 aa gi|91089815|ref|XP_968988.1| PREDICTED: similar to neuroendocrine differentiation factor [Tribolium castaneum] FS765648 fcaL ...

  5. S3EPY: a Sparky extension for determination of small scalar couplings from spin-state-selective excitation NMR experiments

    Czech Academy of Sciences Publication Activity Database

    Novák, P.; Žídek, L.; Motáčková, V.; Padrta, P.; Švenková, Alžběta; Nuzillard, J.-M.; Krásný, Libor; Sklenář, V.

    2010-01-01

    Roč. 46, č. 2 (2010), s. 191-197. ISSN 0925-2738 R&D Projects: GA ČR GA204/09/0583 Institutional research plan: CEZ:AV0Z50200510 Keywords : Software * Sparky * Residual dipolar couplings Subject RIV: EE - Microbiology, Virology Impact factor: 3.047, year: 2010

  6. State ownership and control in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Kočenda, Evžen; Hanousek, Jan

    2012-01-01

    Roč. 45, č. 3 (2012), s. 157-191. ISSN 1573-9414 R&D Projects: GA ČR GA402/09/1595 Institutional support: PRVOUK-P23 Keywords : corporate performance * corporate pyramid * golden share * privatization Subject RIV: AH - Economics

  7. Československí vojenskí diplomati a ich postoj k okupácii a kolaborácii

    Czech Academy of Sciences Publication Activity Database

    Zudová-Lešková, Zlatica

    Praha : Ministerstvo obrany ČR, 2010 - (Pejčoch, I.; Plachý, J.), s. 167-191 ISBN 978-80-7278-529-2 Institutional research plan: CEZ:AV0Z80150510 Keywords : World War II * Military * Diplomats Subject RIV: AB - History

  8. Defect states induced UV-laser irradiation in scintillating glasses

    Czech Academy of Sciences Publication Activity Database

    Pazzi, G.P.; Fabeni, P.; Susini, C.; Nikl, Martin; Mihóková, Eva; Solovieva, Natalia; Nitsch, Karel; Martini, M.; Vedda, A.; Baccaro, S.; Cecilia, A.; Babin, V.

    2002-01-01

    Roč. 191, - (2002), s. 366-370. ISSN 0168-583X Grant ostatní: NATO(XX) SfP973510 Institutional research plan: CEZ:AV0Z1010914 Keywords : Tb 3+ -doped phosphate glasses * thermoluminescence * radiation induced absorption * colour centres Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.158, year: 2002

  9. Stratigraphy and Stress History Recorded by a Complex Volcano-Tectonic Feature in the Nemesis Tessera Quadrangle, Venus

    Science.gov (United States)

    Doggett, T. C.; Grosfils, E. B.

    2002-01-01

    The stress history of a feature, identified as a previously uncataloged dike swarm, at 45N 191E is mapped as clockwise rotation of maximum horizontal compressive stress. It is intermediate between areas associated with compression, mantle upwelling and convection. Additional information is contained in the original extended abstract.

  10. Fractal Growth of Bacterial Colonies

    Czech Academy of Sciences Publication Activity Database

    Růžička, Marek; Fridrich, Miroslav; Burkhard, M.

    London : Chapman&Hall, 1995 - (Novak, M.M.), s. 179-191 ISBN 0-412-71020-X. [Fractal Reviews in the Natural and Applied Sciences. Marseille (FI), 07.02.1995-10.02.1995] Institutional support: RVO:67985858 Keywords : fractal * bacteria l colony * growth pattern Subject RIV: CI - Industrial Chemistry, Chemical Engineering

  11. Individual Differences in Growth in Executive Function across the Transition to School Predict Externalizing and Internalizing Behaviors and Self-Perceived Academic Success at 6 Years of Age

    Science.gov (United States)

    Hughes, Claire; Ensor, Rosie

    2011-01-01

    Building on an existing latent variable analysis of executive function (EF) in children (N=191, 57% boys and 43% girls) making the transition to school (Hughes et al. (2010), "Developmental Neuropsychology", vol. 35, pp. 20-36), the current study both documented average developmental improvements from 4 to 6 years of age and examined individual…

  12. Gender and Depressive Symptoms in 711 Patients With Bipolar Disorder Evaluated Prospectively in the Stanley Foundation Bipolar Treatment Outcome Network

    NARCIS (Netherlands)

    Altshuler, Lori L.; Kupka, Ralph W.; Hellemann, Gerhard; Frye, Mark A.; Sugar, Catherine A.; McElroy, Susan L.; Nolen, Willem A.; Grunze, Heinz; Leverich, Gabriele S.; Keck, Paul E.; Zermeno, Melanie

    2010-01-01

    Objective: The authors assessed gender differences in the proportion of clinical visits spent depressed, manic, or euthymic in patients with bipolar disorder. Method: Data were analyzed from 711 patients with bipolar I or II disorder who were followed prospectively over 7 years (13,191 visits). The

  13. Domain Modeling: NP_849191.3 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_849191.3 chr17 Crystal structure of unliganded human CD21 SCR1-SCR2 (Complement ...receptor type 2) c1w2ra_ chr17/NP_849191.3/NP_849191.3_apo_94-191.pdb c1ly2a_ chr17/NP_849191.3/NP_849191.3_

  14. Subjectivity as a play of territorialization: Exploring affective attachments to place through collective biography

    Czech Academy of Sciences Publication Activity Database

    Zábrodská, Kateřina; Ellwood, C.

    2011-01-01

    Roč. 21, č. 2 (2011), s. 180-191. ISSN 1210-3055 R&D Projects: GA ČR GPP407/10/P146 Institutional research plan: CEZ:AV0Z70250504 Keywords : collective biography * subjectivity * territorialization Subject RIV: AN - Psychology http://www.springerlink.com/content/27584v651qm45w41/

  15. 16 CFR 1611.33 - Test procedures for textile fabrics and film.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Test procedures for textile fabrics and film... procedures for textile fabrics and film. (a)(1) All textile fabrics (except those with a nitro-cellulose... Clothing Textiles, Commercial Standard 191-53”. (2) Notwithstanding the provisions of paragraph (a)(1)...

  16. Translation and Short-Term L2 Vocabulary Retention: Hindrance or Help?

    Science.gov (United States)

    Hummel, Kirsten M.

    2010-01-01

    This study addresses the role that active translation may have in second language (L2) vocabulary learning. Some research suggests that translation might be an effective cognitive strategy for L2 vocabulary learning. Participants were 191 native French-speaking students enrolled in a TESL (Teaching English as a Second Language) program.The study…

  17. 7 CFR 1.412 - Institution of proceedings.

    Science.gov (United States)

    2010-01-01

    ... a sourcing area application by the Office of Administrative Law Judges, pursuant to 36 CFR 223.190... to 36 CFR 223.191(e), based on the written request. If no agreement is reached in the informal review... review process, within 5 working days of the meeting convened during the informal review (36 CFR...

  18. Los partidos políticos y sus fundaciones en el ámbito europeo: análisis a la luz del Reglamento (UE, EURATOM) nº 1141/2014 del Parlamento Europeo y del Consejo de 22 de octubre de 2014 sobre el estatuto y la financiación de los partidos políticos eu

    OpenAIRE

    Constantinesco, Vlad

    2015-01-01

    El Parlamento europeo y el Consejo ya adoptaron, en 2003, un reglamento sobre fundaciones y partidos políticos a la escala europea, como lo requería el art. 191 §2 T CE. El nuevo reglamento procura colmar algunas de las lagunas del texto precedente, in

  19. Gamma radiation effects on hydrogen-terminated nanocrystalline diamond bio-transistors

    Czech Academy of Sciences Publication Activity Database

    Krátká, Marie; Babchenko, Oleg; Ukraintsev, Egor; Vachelová, Jana; Davídková, Marie; Vandrovcová, Marta; Kromka, Alexander; Rezek, Bohuslav

    2016-01-01

    Roč. 63, Mar (2016), 186-191. ISSN 0925-9635 R&D Projects: GA ČR(CZ) GBP108/12/G108 Institutional support: RVO:68378271 ; RVO:61389005 ; RVO:67985823 Keywords : diamond thin films * field effect transistors * proteins * cells * gamma irradiation * atomic force microscope * biosensors Subject RIV: BO - Biophysics Impact factor: 1.919, year: 2014

  20. Targeted design of α-MnO2 based catalysts for oxygen reduction

    Czech Academy of Sciences Publication Activity Database

    Lehtimäki, Matti; Hoffmannová, Hana; Boytsová, Olga; Bastl, Zdeněk; Bush, M.; Halck, N. B.; Rossmeisl, J.; Krtil, Petr

    2016-01-01

    Roč. 191, FEB 2016 (2016), s. 452-461. ISSN 0013-4686 EU Projects: European Commission(XE) 214936 - ELCAT Institutional support: RVO:61388955 Keywords : electrocatalysis * oxygen reduction * MnO2 Subject RIV: CG - Electrochemistry Impact factor: 4.504, year: 2014

  1. EST Table: BP114833 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BP114833 brP-0019 10/09/28 67 %/191 aa ref|XP_002432101.1| GDP-L-fucose ... synthetase, putative [Pe ... diculus humanus corporis] gb|EEB19363.1| GDP-L-fucose ... synthetase, putative [Pediculus humanus corporis] ...

  2. Měření tenzoru napjatosti horninového masivu pomocí kuželové sondy

    Czech Academy of Sciences Publication Activity Database

    Staš, Lubomír; Knejzlík, Jaromír; Rambouský, Zdeněk

    2005-01-01

    Roč. 5, č. 2 (2005), s. 179-191. ISSN 1213-1962 R&D Projects: GA ČR(CZ) GA105/01/1242 Institutional research plan: CEZ:AV0Z30860518 Keywords : stress measurement * stress tensor Subject RIV: DH - Mining, incl. Coal Mining

  3. PARENTAL INFLUENCES ON YOUNG GIRLS' FRUIT AND VEGETABLE, MICRONUTRIENT, AND FAT INTAKES.

    Science.gov (United States)

    To evaluate parents' fruit and vegetable intake and their use of pressure to eat in child feeding as predictors of their 5-year-old daughters' fruit and vegetable, micronutrient, and fat intakes. Data were obtained from 191 non-Hispanic white families with 5-year-old girls. Parent data included repo...

  4. Thermal characterization of montmorillonite clays saturated with various cations

    Czech Academy of Sciences Publication Activity Database

    Balek, V.; Beneš, M.; Šubrt, Jan; Pérez, R.

    2008-01-01

    Roč. 92, č. 1 (2008), s. 191-197. ISSN 1388-6150 R&D Projects: GA MŠk LC523 Institutional research plan: CEZ:AV0Z40320502 Keywords : collapse of interlayer space * dehydration * emanation thermal analysis Subject RIV: CA - Inorganic Chemistry Impact factor: 1.630, year: 2008

  5. Iron oxide modified minerals

    Czech Academy of Sciences Publication Activity Database

    Mashlan, M.; Bartoňková, H.; Jančík, D.; Tuček, J.; Martinec, Petr

    2009-01-01

    Roč. 191, 1-3 (2009), s. 151-157. ISSN 0304-3843 Institutional research plan: CEZ:AV0Z30860518 Keywords : Mössbauer spectroscopy * clay minerals * iron oxide * nanoparticle Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.209, year: 2007 http://www.springerlink.com/content/9870444lu2g66382/fulltext.pdf

  6. Pediatric Palliative Care: A Personal Story

    Medline Plus

    Full Text Available ... Young Adult Cancer Program - Duration: 11:08. UCLA Health 191,156 views 11:08 A Day in the Life - Lauren (Nurse Practitioner- Palliative Care) - Duration: 2:56. JNJDiscoverNursing 8,458 views 2: ...

  7. Dicty_cDB: Contig-U08145-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 04 AF059883_1( AF059883 |pid:none) Drosophila robusta Cu-Zn superoxid... 46 0.004 DQ121374_1( DQ121374 |pid:none) Macrobrachium rosen...bergii copper/z... 45 0.005 AE008922_191( AE008922 |pid:

  8. Leben und Leiden der Deutschen Akademie für Musik und darstellende Kunst in Prag der Zwischenkriegszeit

    Czech Academy of Sciences Publication Activity Database

    Bajgarová, Jitka

    Koper: Založba Univerze na Primorskem Koper; Akademija za glasbo Ljubljana; Festival Ljubljana; Slovenska filharmonija Ljubljana, 2015 - (Vinkler, J.; Weiss, J.), s. 191-201 ISBN 978-961-6963-21-3 Institutional support: RVO:68378076 Keywords : music conservatory * German culture * Prague * 1918-1938 Subject RIV: AL - Art, Architecture, Cultural Heritage

  9. Bacterial lysate Stava in prevention and therapy of chronic respiratory tract infection

    Czech Academy of Sciences Publication Activity Database

    Čížová, Hana; Ryšánková, J.; Pillich, Jan; Vondráček, Jiří

    Hradec Králové: Purkyně Military Medical Academy, 1995. s. 184-191. [Experimental, Therapeutic and Toxic Manipulations of Host Defence System . 12.06.1995-15.06.1995, Hradec Králové] Keywords : bacterial lysate * respiration tract infection * chemiluminescence * phagocytosis * lymphocyte * proliferation

  10. Odbourávání nikotinu na fotoaktivních katalyzátorech různé provenience

    Czech Academy of Sciences Publication Activity Database

    Brožek, Vlastimil; Mastný, L.; Šrank, Z.; Eliáš, M.; Janča, J.

    Praha : Procesní inženýrství Praha, 2005 - (Novosad, J.), s. 191 ISBN 80-86059-42-1. [CHISA 2005 , 52.. Srní (CZ), 17.10.2005-20.10.2005] Institutional research plan: CEZ:AV0Z20430508 Keywords : photoactivity * plasma deposition * spheroidisation * nicotine Subject RIV: JJ - Other Materials

  11. Independent Control of Positive- and Negative-Sequence Current Components in a Doubly Fed Machine

    Czech Academy of Sciences Publication Activity Database

    Bendl, Jiří; Chomát, Miroslav; Schreier, Luděk

    2005-01-01

    Roč. 15, č. 3 (2005), s. 191-202. ISSN 1430-144X R&D Projects: GA ČR(CZ) GA102/03/0046 Institutional research plan: CEZ:AV0Z20570509 Keywords : vector control * adjustable speed generation systems * converter control Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 0.056, year: 2005

  12. DMPD: Manipulation of mitogen-activated protein kinase/nuclear factor-kappaB-signalingcascades during intracellular Toxoplasma gondii infection. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15361242 Manipulation of mitogen-activated protein kinase/nuclear factor-kappaB-sig...mmunol Rev. 2004 Oct;201:191-205. (.png) (.svg) (.html) (.csml) Show Manipulation of mitogen-activated protein kinase/nuclear... gondii infection. PubmedID 15361242 Title Manipulation of mitogen-activated protein kinase/nuclear factor-k

  13. Existence of global mild and strong solutions to stochastic hyperbolic evolution equations driven by a spatially homogeneous Wiener process

    Czech Academy of Sciences Publication Activity Database

    Ondreját, Martin

    2004-01-01

    Roč. 4, č. 2 (2004), s. 169-191. ISSN 1424-3199 R&D Projects: GA ČR GA201/01/1197 Institutional research plan: CEZ:AV0Z1019905 Keywords : stochastic hyperbolic equations * homogeneous Wiener process Subject RIV: BA - General Mathematics Impact factor: 0.684, year: 2002

  14. A Lighthouse in the Desert? Evaluating the Effects of Creativity Training on Employee Innovation

    Science.gov (United States)

    Birdi, Kamal

    2007-01-01

    The contribution of three different creativity training programmes to employees' workplace idea generation and implementation was evaluated. The research was conducted within a government organization, where 191 employees (a mixture of participants and non-participants in creativity training) were surveyed. Analyses showed that creativity training…

  15. Povodně a pomoc z perspektivy zasažených

    Czech Academy of Sciences Publication Activity Database

    Kohoutek, Tomáš; Urbánek, Tomáš; Čermák, Ivo; Baštecká, B.

    1. Praha: Academia, 2009 - (Kohoutek, T.; Čermák, I.), s. 110-191 ISBN 978-80-200-1816-8 Institutional research plan: CEZ:AV0Z70250504 Keywords : floods * trauma * psychosocial assistance Subject RIV: AN - Psychology

  16. Host genetic architecture and the landscape of microbiome composition: humans weigh in

    OpenAIRE

    Benson, Andrew K.

    2015-01-01

    Comparative analyses of the control of mammalian microbiomes by host genetic architecture reveal striking conserved features that have implications for the evolution of host–microbiome interactions. See related Research article: http://www.genomebiology.com/2015/16/1/191

  17. Juan Caramuel on Future Contingents

    Czech Academy of Sciences Publication Activity Database

    Dvořák, Petr

    Praha : Filosofia, 2002 - (Beneš, J.; Glombíček, P.; Urbánek, V.), s. 191-207 ISBN 80-7007-158-3 Institutional research plan: CEZ:AV0Z9009908 Keywords : philosophy Subject RIV: AA - Philosophy ; Religion

  18. Minimally Invasive Endoscopic and Endoscopy-Assisted Microsurgery of Vestibular Schwannoma

    Czech Academy of Sciences Publication Activity Database

    Betka, J.; Chovanec, M.; Zvěřina, E.; Profant, Oliver; Lukeš, P.; Skřivan, J.; Kluh, J.; Fík, Z.

    Rijeka : InTech, 2011, s. 191-216. ISBN 978-953-307-717-8 R&D Projects: GA MZd NT12459 Institutional research plan: CEZ:AV0Z50390512; CEZ:AV0Z50390703 Keywords : vestibular schwannoma * microscopy and endoscopy Subject RIV: FJ - Surgery incl. Transplants; FH - Neurology (UEM-P)

  19. Temac a.s

    Czech Academy of Sciences Publication Activity Database

    Bohatá, Marie

    New York : M.E. Sharpe, 2000 - (Estrin, S.; Richet, X.; Brada, J.), s. 176-191 ISBN 0-7656-0255-5 Institutional research plan: CEZ:AV0Z7085904 Keywords : foreign investment * case study * Temac a.s. Subject RIV: AH - Economics

  20. 77 FR 18897 - Greek Independence Day: A National Day of Celebration of Greek and American Democracy, 2012

    Science.gov (United States)

    2012-03-28

    .... (Presidential Sig.) [FR Doc. 2012-7640 Filed 3-27-12; 11:15 am] Billing code 3295-F2-P ... Two hundred and thirty-six years ago, a new American Nation was founded on an old Greek principle... nation. Today, on the 191st anniversary of Greece's independence, we commemorate that struggle to...

  1. AcEST: BP911533 [AcEST

    Lifescience Database Archive (English)

    Full Text Available HUMAN cDNA FLJ35079 fis, clone PLACE6005283, hi... 33 7.1 tr|Q7ZZ40|Q7ZZ40_DANRE Novel protein similar to human autism...6 +P+V VS Sbjct: 191 VPKSPSVDKYNVS 203 >tr|Q7ZZ40|Q7ZZ40_DANRE Novel protein similar to human autism-related

  2. Water column characteristics following the September 2004 stench event off southern Malabar coast

    Digital Repository Service at National Institute of Oceanography (India)

    Kurian, S.; Shenoy, D.M.; Gauns, M.; Roy, R.; Narvenkar, G.; Pratihary, A.K.; Paul, J.T.

    that phytoplankton were dominated by holococcolithophorids (max 27 x 10 sup(6) cells l sup(-1)) in the coastal stations in comparison with the offshore stations (max 8000 cells l sup(-1)), which contained mainly diatoms. Slightly low oxygen concentration (81-191 Mu M...

  3. The oldest Czech fishpond discovered? An interdisciplinary approach to reconstruction of local vegetation in mediaeval Prague suburbs

    Czech Academy of Sciences Publication Activity Database

    Pokorná, Adéla; Houfková, P.; Novák, J.; Bešta, T.; Kovačiková, L.; Nováková, K.; Zavřel, J.; Starec, P.

    2014-01-01

    Roč. 730, č. 1 (2014), s. 191-213. ISSN 0018-8158 Grant ostatní: GA ČR(CZ) GA13-11193S Institutional support: RVO:67985912 Keywords : archaeobotany * archaeozoology * environmental changes * human impact * fishpond * hydrobiology * Prague * the Middle Ages * vegetation diversity Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 2.275, year: 2014

  4. Drug: D04613 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D04613 Drug Iridium Ir 192 (USAN); Iriditope (TN) Ir 191.9626 192.217 D04613.gif Radioactive age ... nt CAS: 14694-69-0 PubChem: 47206457 ATOM ... 1 1 Z Ir 21.0700 -16.3100 BOND 0 InChI=1S/Ir/i1+0 ...

  5. Morphology and mechanical properties of polypropylene/polystyrene blends compatibilized with styrene-butadiene block copolymers

    Czech Academy of Sciences Publication Activity Database

    Fortelný, Ivan; Minkova, L. I.; Kotek, Jiří; Lapčíková, Monika; Michálková, Danuše

    2012-01-01

    Roč. 52, č. 1 (2012), s. 191-204. ISSN 0032-3888 R&D Projects: GA ČR GA106/06/0729; GA AV ČR IAA200500903 Institutional research plan: CEZ:AV0Z40500505 Keywords : polymer blends * compatibilization * morphology Subject RIV: JI - Composite Materials Impact factor: 1.243, year: 2012

  6. Foster Parents' Involvement in Authoritative Parenting and Interest in Future Parenting Training

    Science.gov (United States)

    King, Keith A.; Kraemer, Linda K.; Bernard, Amy L.; Vidourek, Rebecca A.

    2007-01-01

    We surveyed 191 Southwest Ohio foster parents regarding their involvement in authoritative parenting and interest for additional parenting education. Our results showed that most respondents reported using an authoritative parenting style and were interested in receiving future training. Involvement in authoritative parenting differed…

  7. Cognition-Based and Affect-Based Trust as Mediators of Leader Behavior Influences on Team Performance

    Science.gov (United States)

    Schaubroeck, John; Lam, Simon S. K.; Peng, Ann Chunyan

    2011-01-01

    We develop a model in which cognitive and affective trust in the leader mediate the relationship between leader behavior and team psychological states that, in turn, drive team performance. The model is tested on a sample of 191 financial services teams in Hong Kong and the U.S. Servant leadership influenced team performance through affect-based…

  8. Susceptibility of the MMPI-2 Clinical, Restructured Clinical (RC), and Content Scales to Overreporting and Underreporting

    Science.gov (United States)

    Sellbom, Martin; Ben-Porath, Yossef S.; Graham, John R.; Arbisi, Paul A.; Bagby, R. Michael

    2005-01-01

    The authors examined and compared the susceptibility of three Minnesota Multiphasic Personality Inventory-2 (MMPI-2) scale sets (Clinical, Restructured Clinical [RC], and Content) to over- and underreporting using five analog samples. Two samples of 85 and 191 undergraduate students, respectively, took the MMPI-2 under underreporting versus…

  9. 7 CFR 272.1 - General terms and conditions.

    Science.gov (United States)

    2010-01-01

    ... applying for food stamp benefits, through the Systematic Alien Verification for Entitlements (SAVE) Program..., other eligibility criteria, such as work registration, resources, tax dependency, and alien status... 9, 1981. (30) Amendment 191. Areas subject to the photo ID card requirement must have issued...

  10. K voprosu o roždeniji „tvorčeskoj ikonopisi“ (na primere čechoslovackich rabot J. Rejtlinger)

    Czech Academy of Sciences Publication Activity Database

    Jančárková, Julie

    -, 191/2 (2006), s. 285-294. ISSN 0767-7294. [Pravoslavije i russkoje obščestvo v načalě 3. tysjačeletija. Moskva, 07.12.2005-08.12.2005] Institutional research plan: CEZ:AV0Z90920516 Keywords : icons * Rejtlinger J. Subject RIV: AL - Art, Architecture, Cultural Heritage

  11. Microalgae as a means for converting flue gas CO2 into biomass with a high content of starch

    Czech Academy of Sciences Publication Activity Database

    Doušková, Irena; Doucha, Jiří; Machat, J.; Novák, P.; Umysová, Dáša; Vítová, Milada; Zachleder, Vilém

    Guimaraes : Universidade do Minho, 2008, s. 191-196. ISBN 978-989-20-0741-0. [International Conference: Bioenegy: Challenges and Opportunities. Guimaraes (PT), 06.04.2008-09.04.2008] R&D Projects: GA MŠk OE 221 Institutional research plan: CEZ:AV0Z50200510 Keywords : microalgae * chlorella vulgaris * starch Subject RIV: EE - Microbiology, Virology

  12. EST Table: CK561988 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK561988 rswpb0_004912.y1 10/09/29 64 %/191 aa ref|XP_001605087.1| PREDICTED: similar to fetal alzheimer... PREDICTED: similar to fetal alzheimer antigen, falz [Tribolium castaneum] CK536202 swp ...

  13. Problém interpretace vědecké teorie

    Czech Academy of Sciences Publication Activity Database

    Havlík, Vladimír

    Bratislava: Filozofický ústav SAV, 2004, s. 179-191. ISBN 80-967225-1-4. [Sympózium analytickej filozofie /7./. Bratislava (SK), 03.09.2003-05.09.2003] Institutional research plan: CEZ:AV0Z9009908 Keywords : interpretation * scientific theory Subject RIV: AA - Philosophy ; Religion

  14. 40 CFR 194.22 - Quality assurance.

    Science.gov (United States)

    2010-07-01

    ... COMPLIANCE WITH THE 40 CFR PART 191 DISPOSAL REGULATIONS Compliance Certification and Re-certification General Requirements § 194.22 Quality assurance. (a)(1) As soon as practicable after April 9, 1996, the... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Quality assurance. 194.22 Section...

  15. Physical properties of PE nanocomposites as a function of percentage of wood fibres

    Czech Academy of Sciences Publication Activity Database

    Kokta, B. V.; Kwei-Nam, L.; Fortelný, Ivan; Lednický, František; Kruliš, Zdeněk

    Plzeň : Dům techniky Plzeň, spol. s.r.o, 2007, s. 191-196. ISBN 978-80-239-8857-4. [International Conference on Reinforced Plastics /24./. Karlovy Vary (CZ), 22.05.2007-24.05.2007] Institutional research plan: CEZ:AV0Z40500505 Keywords : PE nanocomposites * wood fibres Subject RIV: CD - Macromolecular Chemistry

  16. Evaluation and Analyses of Cultural Diversity Training with Environmental Educators

    Science.gov (United States)

    Galvan, Alma R.; LaRocque, Lisa

    2010-01-01

    The Environmental Education and Training Partnership Cultural Diversity Workshops were based on theoretical models and designed to increase individuals' awareness, knowledge, and intentions toward increasing culturally sensitivity. This study reports on the evaluation results from 191 participants. Their responses indicate significant changes in…

  17. AcEST: BP916574 [AcEST

    Lifescience Database Archive (English)

    Full Text Available .8 tr|Q4SAB0|Q4SAB0_TETNG Chromosome 19 SCAF14691, whole genome sho... 34 4.8 tr|A1AVA3|A1AVA3_RUTM...GCLTTYFELQELRGENCCFCPKCG 191 Query: 108 VYHPCRVG 85 P + G Sbjct: 192 TQTPSKWG 199 >tr|A1AVA3|A1AVA3_RUTM

  18. Leadership in Distance Education: Qualities and Qualifications Sought by Higher Education Institutions

    Science.gov (United States)

    Nworie, John; Haughton, Noela; Oprandi, Stephanie

    2012-01-01

    This article presents the results of an investigation into the qualities and qualifications sought in distance education leaders by institutions of higher education in the United States. The researchers examined 191 distance education leadership position announcements posted by online sources between 1997 and 2010. Content analysis of these…

  19. Fundamentals for remote structural health monitoring of wind turbine blades - a preproject. Annex E. Full-scale test of wind turbine blade, using sensors and NDT

    DEFF Research Database (Denmark)

    Kristensen, O.J.D.; McGugan, Malcolm; Sendrup, P.;

    2002-01-01

    A 19.1 metre wind turbine blade was subjected to static tests. The purpose of the test series was to verify the abilities of different types of sensors to detect damage in wind turbine blades. Prior to each of the static test-series an artificial damagewas made on the blade. The damage made for...

  20. Křesťanství v jižní Asii

    Czech Academy of Sciences Publication Activity Database

    Holman, Jaroslav

    Praha : Orientální ústav AV ČR, 2005 - (Vavroušková (editor), S.), s. 191-241 ISBN 80-85425-57-2 Institutional research plan: CEZ:AV0Z90210515 Keywords : Christianity in South Asia * India Subject RIV: AA - Philosophy ; Religion