An institutional review board-based clinical research quality assurance program.

Science.gov (United States)

Lad, Pramod M; Dahl, Rebecca

2013-01-01

Despite the acknowledged importance of quality assurance in the clinical research process, the problem of how such a program should be implemented at the level of an academic teaching hospital or a similar institution has not been addressed in the literature. Despite the fact that quality assurance is expected in programs which certify and accredit Institutional Review Boards (IRBs), very little is known about the role of the IRB in programs of clinical research quality assurance. In this article we consider the definition of clinical research quality assurance, and describe a program designed to achieve it. The key elements of such a program are education at the site level, which has both mandatory and voluntary components, and an auditing and monitoring program, which reinforces the education on quality assurance. The role of the IRB in achieving the program goals and the organizational placement of the quality assurance program within the IRB structure and function are important items of discussion.

Quality assurance of 3-D conformal radiation therapy for a cooperative group trial - RTOG 3D QA center initial experience

International Nuclear Information System (INIS)

Michalski, Jeff M.; Purdy, James A.; Harms, William B.; Bosch, Walter R.; Oehmke, Frederick; Cox, James D.

1996-01-01

PURPOSE: 3-D conformal radiation therapy (3DCRT) holds promise in allowing safe escalation of radiation dose to increase the local control of prostate cancer. Prospective evaluation of this new modality requires strict quality assurance (QA). We report the results of QA review on patients receiving 3DCRT for prostate cancer on a cooperative group trial. MATERIALS and METHODS: In 1993 the NCI awarded the ACR/RTOG and nine institutions an RFA grant to study the use of 3DCRT in the treatment of prostate cancer. A phase I/II trial was developed to: a) test the feasibility of conducting 3DCRT radiation dose escalation in a cooperative group setting; b) establish the maximum tolerated radiation dose that can be delivered to the prostate; and c) quantify the normal tissue toxicity rate when using 3DCRT. In order to assure protocol compliance each participating institution was required to implement data exchange capabilities with the RTOG 3D QA center. The QA center reviews at a minimum the first five case from each participating center and spot checks subsequent submissions. For each case review the following parameters are evaluated: 1) target volume delineation, 2) normal structure delineation, 3) CT data quality, 4) field placement, 5) field shaping, and 6) dose distribution. RESULTS: Since the first patient was registered on August 23, 1994, an additional 170 patients have been accrued. Each of the nine original approved institutions has participated and three other centers have recently passed quality assurance bench marks for study participation. Eighty patients have been treated at the first dose level (68.4 Gy minimum PTV dose) and accrual is currently ongoing at the second dose level (73.8 Gy minimum PTV dose). Of the 124 cases that have undergone complete or partial QA review, 30 cases (24%) have had some problems with data exchange. Five of 67 CT scans were not acquired by protocol standards. Target volume delineation required the submitting institution

Standard Review Plan for the review of financial assurance mechanisms for decommissioning under 10 CFR Parts 30, 40, 70, and 72

International Nuclear Information System (INIS)

1989-08-01

Standard Review Plan (SRP) for the Review of Financial Assurance Mechanisms for Decommissioning under 10 CFR Parts 30, 40, 70 and 72, is prepared for the guidance of Nuclear Regulatory Commission staff reviewers in performing reviews of applications from material licensees affected by the decommissioning regulations established June 27, 1988 (53FR24018). The principal purpose of the SRP is to assure the quality and uniformity of staff reviews and to present a base from which to evaluate the financial assurance aspects of the applications. The SRP identifies who performs the review, the matters that are reviewed, the basis for the review, how the review is performed, and the conclusions that are sought

Quality assurance in digital dental imaging: a systematic review.

Science.gov (United States)

Metsälä, Eija; Henner, Anja; Ekholm, Marja

2014-07-01

Doses induced by individual dental examinations are low. However, dental radiography accounts for nearly one third of the total number of radiological examinations in the European Union. Therefore, special attention is needed with regard to radiation protection. In order to lower patient doses, the staff performing dental examinations must have competence in imaging as well as in radiation protection issues. This paper presents a systematic review about the core competencies needed by the healthcare staff in performing digital dental radiological imaging quality assurance. The following databases were searched: Pubmed, Cinahl, Pro Quest and IEEXplore digital library. Also volumes of some dental imaging journals and doctoral theses of the Finnish universities educating dentists were searched. The search was performed using both MeSH terms and keywords using the option 'search all text'. The original keywords were: dental imaging, digital, x-ray, panoramic, quality, assurance, competence, competency, skills, knowledge, radiographer, radiologist technician, dentist, oral hygienist, radiation protection and their Finnish synonyms. Core competencies needed by the healthcare staff performing digital dental radiological imaging quality assurance described in the selected studies were: management of dental imaging equipment, competence in image quality and factors associated with it, dose optimization and quality assurance. In the future there will be higher doses in dental imaging due to increasing use of CBCT and digital imaging. The staff performing dental imaging must have competence in dental imaging quality assurance issues found in this review. They also have to practice ethical radiation safety culture in clinical practice.

History of Reliability and Quality Assurance at Kennedy Space Center

Science.gov (United States)

Childers, Frank M.

2004-01-01

This Kennedy Historical Document (KHD) provides a unique historical perspective of the organizational and functional responsibilities for the manned and un-manned programs at Kennedy Space Center, Florida. As systems become more complex and hazardous, the attention to detailed planning and execution continues to be a challenge. The need for a robust reliability and quality assurance program will always be a necessity to ensure mission success. As new space missions are defined and technology allows for continued access to space, these programs cannot be compromised. The organizational structure that has provided the reliability and quality assurance functions for both the manned and unmanned programs has seen many changes since the first group came to Florida in the 1950's. The roles of government and contractor personnel have changed with each program and organizational alignment has changed based on that responsibility. The organizational alignment of the personnel performing these functions must ensure independent assessment of the processes.

Radiation Therapy Deficiencies Identified During On-Site Dosimetry Visits by the Imaging and Radiation Oncology Core Houston Quality Assurance Center.

Science.gov (United States)

Kry, Stephen F; Dromgoole, Lainy; Alvarez, Paola; Leif, Jessica; Molineu, Andrea; Taylor, Paige; Followill, David S

2017-12-01

To review the dosimetric, mechanical, and programmatic deficiencies most frequently observed during on-site visits of radiation therapy facilities by the Imaging and Radiation Oncology Core Quality Assurance Center in Houston (IROC Houston). The findings of IROC Houston between 2000 and 2014, including 409 institutions and 1020 linear accelerators (linacs), were compiled. On-site evaluations by IROC Houston include verification of absolute calibration (tolerance of ±3%), relative dosimetric review (tolerances of ±2% between treatment planning system [TPS] calculation and measurement), mechanical evaluation (including multileaf collimator and kilovoltage-megavoltage isocenter evaluation against Task Group [TG]-142 tolerances), and general programmatic review (including institutional quality assurance program vs TG-40 and TG-142). An average of 3.1 deficiencies was identified at each institution visited, a number that has decreased slightly with time. The most common errors are tabulated and include TG-40/TG-142 compliance (82% of institutions were deficient), small field size output factors (59% of institutions had errors ≥3%), and wedge factors (33% of institutions had errors ≥3%). Dosimetric errors of ≥10%, including in beam calibration, were seen at many institutions. There is substantial room for improvement of both dosimetric and programmatic issues in radiation therapy, which should be a high priority for the medical physics community. Particularly relevant was suboptimal beam modeling in the TPS and a corresponding failure to detect these errors by not including TPS data in the linac quality assurance process. Copyright © 2017 Elsevier Inc. All rights reserved.

A quality assurance program for radiotherapy centers in the Republic of Korea

International Nuclear Information System (INIS)

Kim, G.Y.; Lee, H.K.; Park, K.J.; Oh, H.J.

2002-01-01

Recognizing the importance of quality assurance in radiotherapy and the need to make access to radiation standards traceable to the international measurement system to every radiotherapy center, the KFDA, as a national secondary standard dosimetry laboratory (SSDL), has started a quality assurance program from 1999. This program was initiated by tele-survey to all radiotherapy centers regarding general information about their radiotherapists, medical physicists, type of equipment, dosimeters, etc. This provided the KFDA with a data file and led to links between the KFDA and the clinics. In 1999 a national quality assurance program for ensuring dosimetry accuracy has been performed by on-site dosimetry for 4 60 Co γ ray, 47 high-energy photon beams used in 43 centers. During the audits, the procedure followed by the KFDA was to measure the outputs of the LINAC(6 MV) and Co-60 teletherapy units in terms of absorbed dose to water for fixed dose (2 Gy) in water phantom (only one phantom used in this on-site visit). For all the case, the measurements are carried out in a water phantom according to the IAEA recommended code of practice. The distributions of deviations in total audit are given. The results showed deviations varying between -7.11% and 8.38%. KFDA follow up the large deviated radiotherapy centers. The traceability to SSDL is a major factor of deviation between KFDA measurement dose and clinics quoted dose. The correction for air density (temperature and pressure) is a factor that sometimes introduces errors. Most of the clinics do not calibrate their own barometers and sometimes rely on the air pressure that is quoted during measurements by local metrological offices. In one case, the barometer and thermometer of the clinic were deviating from KFDA instruments by about 10 mmHg and 2, respectively even if the temperature was measured in air. In one case, about 4% of output variation with gantry head angle (horizontal vs. vertical). In the past two years the

Standard review plan for the review of environmental restoration remedial action quality assurance program plans

International Nuclear Information System (INIS)

1991-09-01

This plan establishes both the scope of the review and the acceptance criteria to be utilized for the review of Quality Assurance Program Plans (QAPPs) developed in accordance with the requirements of DOE/RL-90-28. DOE/RL-90-28, the Environmental Restoration Remedial Action Quality Assurance Requirements Document (QARD) defines all quality assurance (QA) requirements governing activities that affect the quality of the Environmental Restoration Remedial Action (ERRA) program at the Hanford Site. These requirements are defined in three parts, Part 1 of Quality Management and Administration tasks, Part 2 for Environmental Data Operations, and Part 3 of the Design and Construction of items, systems, and facilities. The purpose of this document is to identify the scope of the review by the DOE Field Office, Richland staff, and establish the acceptance criteria (Parts 1, 2, and 3) that the DOE Field Office, Richland staff will utilize to evaluate the participant QAPPs. Use of the standard review plan will (1) help ensure that participant QAPPs contain the information required by DOE/RL-90-28, (2) aid program participant and DOE Field Office, Richland staff is ensuring that the information describing the participant's QAPP is complete, (3) help persons regarding DOE/RL- 90-28 to locate information, and (4) contribute to decreasing the time needed for the review process. In addition, the Standard Review Plan (SRP) ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate compliance of participant quality programs against DOE/RL-90-28

Interim guidance on the Standard Review Plan for the review of financial assurance mechanisms for decommissioning under 10 CFR Parts 30, 40, and 70

International Nuclear Information System (INIS)

1988-12-01

Interim Guidance on the Standard Review Plan (SRP) for the Review of Financial Assurance Mechanisms for Decommissioning under 10 CFR Parts 30, 40, and 70 is prepared for the guidance of Nuclear Regulatory Commission staff reviewers in performing reviews of applications from material licensees affected by the decommissioning regulations established June 27, 1988 (53FR24018). The principal purpose of the SRP is to assure the quality and uniformity of staff reviews and to present a base from which to evaluate the financial assurance aspects of the applications. NUREG-1337, identifies who performs the review, the matters that are reviewed, the basis of the review, how the review is performed, and the conclusions that are sought. 3 refs

Quality-assurance plan for water-quality activities in the U.S. Geological Survey Washington Water Science Center

Science.gov (United States)

Conn, Kathleen E.; Huffman, Raegan L.; Barton, Cynthia

2017-05-08

In accordance with guidelines set forth by the Office of Water Quality in the Water Mission Area of the U.S. Geological Survey, a quality-assurance plan has been created for use by the Washington Water Science Center (WAWSC) in conducting water-quality activities. This qualityassurance plan documents the standards, policies, and procedures used by the WAWSC for activities related to the collection, processing, storage, analysis, and publication of water-quality data. The policies and procedures documented in this quality-assurance plan for water-quality activities complement the quality-assurance plans for surface-water and groundwater activities at the WAWSC.

Asset Analysis and Operational Concepts for Separation Assurance Flight Testing at Dryden Flight Research Center

Science.gov (United States)

Costa, Guillermo J.; Arteaga, Ricardo A.

2011-01-01

A preliminary survey of existing separation assurance and collision avoidance advancements, technologies, and efforts has been conducted in order to develop a concept of operations for flight testing autonomous separation assurance at Dryden Flight Research Center. This effort was part of the Unmanned Aerial Systems in the National Airspace System project. The survey focused primarily on separation assurance projects validated through flight testing (including lessons learned), however current forays into the field were also examined. Comparisons between current Dryden flight and range assets were conducted using House of Quality matrices in order to allow project management to make determinations regarding asset utilization for future flight tests. This was conducted in order to establish a body of knowledge of the current collision avoidance landscape, and thus focus Dryden s efforts more effectively towards the providing of assets and test ranges for future flight testing within this research field.

Quality Assurance for Clinical Trials

Science.gov (United States)

Ibbott, Geoffrey S.; Haworth, Annette; Followill, David S.

2013-01-01

Cooperative groups, of which the Radiation Therapy Oncology Group is one example, conduct national clinical trials that often involve the use of radiation therapy. In preparation for such a trial, the cooperative group prepares a protocol to define the goals of the trial, the rationale for its design, and the details of the treatment procedure to be followed. The Radiological Physics Center (RPC) is one of several quality assurance (QA) offices that is charged with assuring that participating institutions deliver doses that are clinically consistent and comparable. The RPC does this by conducting a variety of independent audits and credentialing processes. The RPC has compiled data showing that credentialing can help institutions comply with the requirements of a cooperative group clinical protocol. Phantom irradiations have been demonstrated to exercise an institution’s procedures for planning and delivering advanced external beam techniques (1–3). Similarly, RPC data indicate that a rapid review of patient treatment records or planning procedures can improve compliance with clinical trials (4). The experiences of the RPC are presented as examples of the contributions that a national clinical trials QA center can make to cooperative group trials. These experiences illustrate the critical need for comprehensive QA to assure that clinical trials are successful and cost-effective. The RPC is supported by grants CA 10953 and CA 81647 from the National Cancer Institute, NIH, DHHS. PMID:24392352

Guidelines for comprehensive quality assurance in brachytherapy

International Nuclear Information System (INIS)

Goldson, A.L.; Nibhanupudy, J.R.

1984-01-01

Brachytherapy treatment techniques can provide significant improvement in local control and overall survival, but only when quality assurance can be guaranteed. To establish brachytherapy quality assurance, basic requirements for three predetermined subdivisions of clinical institutions will be forwarded. These are: (1) centers having minimum requirements to provide brachytherapy, (2) intermediate centers such as regional or community hospitals, and (3) optimal centers such as university hospital and cancer centers. This presentation will highlight personnel needs, equipment requirements, academic activities, clinical experience with these systems and proposed quality assurance guidelines

Osseointegration: a review of the fundamentals for assuring cementless skeletal fixation

Directory of Open Access Journals (Sweden)

Isaacson BM

2014-04-01

Full Text Available Brad M Isaacson,1,2 Sujee Jeyapalina3,4 1Henry M Jackson Foundation for the Advancement of Military Medicine, 2The Center for Rehabilitation Sciences Research, Department of Physical Medicine and Rehabilitation, Uniformed Services University of Health Sciences, Bethesda, MD, USA; 3Department of Orthopedics, 4Orthopedic Research Laboratory, University of Utah, Salt Lake City, UT, USA Abstract: Direct skeletal fixation, termed osseointegration, has expanded in the last century and includes use in total joint replacements, the edentulous mandible and maxilla, and percutaneous osseointegrated prosthetics. Although it is well known that titanium and bone have the ability to form a durable bone–implant interface, new applications have emerged in the field of orthopedics, which requires a more thorough assessment of the literature. This review aims to introduce the basic biological principles for attaining osseointegration and discusses the major factors for assuring successful cementless fixation. Keywords: osseointegration, bone, skeletal attachment, total joint replacements, dental implants, percutaneous

Lot quality assurance sampling of sputum acid-fast bacillus smears for assessing sputum smear microscopy centers.

Science.gov (United States)

Selvakumar, N; Murthy, B N; Prabhakaran, E; Sivagamasundari, S; Vasanthan, Samuel; Perumal, M; Govindaraju, R; Chauhan, L S; Wares, Fraser; Santha, T; Narayanan, P R

2005-02-01

Assessment of 12 microscopy centers in a tuberculosis unit by blinded checking of eight sputum smears selected by using a lot quality assurance sampling (LQAS) method and by unblinded checking of all positive and five negative slides, among the slides examined in a month in a microscopy centre, revealed that the LQAS method can be implemented in the field to monitor the performance of acid-fast bacillus microscopy centers in national tuberculosis control programs.

Joint CDRH (Center for Devices and Radiological Health) and state quality-assurance surveys in nuclear medicine: Phase 2 - radiopharmaceuticals

International Nuclear Information System (INIS)

Hamilton, D.R.; Evans, C.D.

1986-08-01

The report discusses survey results on aspects of the quality assurance of radio-pharmaceuticals from 180 nuclear-medicine facilities in the United States. Data were collected from facilities in 8 states. Demographic information about nuclear-medicine operations and quality-assurance programs was gathered by state radiation-control-program personnel. The data collected from the survey show an incomplete acceptance of quality-assurance practices for radiopharmaceuticals. Most of the facilities in the survey indicated that, because an inferior radiopharmaceutical was prepared so infrequently, they did not believe it was cost-effective to perform extensive quality-assurance testing. The Center for Devices and Radiological Health hopes that the information from the survey will stimulate nuclear-medicine professionals and their organizations to encourage appropriate testing of all radiopharmaceuticals

Quality assurance

International Nuclear Information System (INIS)

1996-01-01

The main efforts of Nuclear Regulatory Authority of the Slovak Republic (NRA SR) was focused on support of quality assurance programmes development at responsible organizations Bohunice V-1 and V-v and Mochovce NPPs and their inspection. Development of the level two documentation of a partial quality assurance programme for NPP operation continued at Mochovce NPP. Most of documentation has been submitted to NRA SR for comments and approval. NRA SR invited a mission of French experts to Mochovce NPP to review preparation and performance of internal audits that would be beneficial for improvement in this kind activities at the NPP. Bohunice NPP continued in development of a partial quality assurance programme for operation. The Quality Assurance Programme submitted to NRA SR for approval. Based on a request of Bohunice NPPs, NRA SR consulted the draft quality assurance programme developed by Siemens for stage of the 'Basic Design' of V-1 NPP upgrading. The programme had not been submitted for approval to NRA SR prior to completion of works by Siemens. Based on an internal audit that had been performed, corrective measures were proposed to meet requirements on review and approval of suppliers quality assurance programmes. Requirements related to the quality assurance at nuclear installations were prepared to be incorporated into principles of a act on peaceful use of nuclear power in Slovak Republic

BYU Food Quality Assurance Laboratory

Data.gov (United States)

Federal Laboratory Consortium — The Quality Assurance Lab is located in the Eyring Science Center in the department of Nutrition, Dietetics, and Food Science. The Quality Assurance Lab has about 10...

DOE financial assurance presentation

International Nuclear Information System (INIS)

Huck, R.

1990-01-01

The presentation topic is California's approach to license application review in meeting financial assurances for the proposed Ward Valley site. The purpose of the presentation is to provide information on specific financial assurance provisions contained in 10 CFR Part 61 and how California intends to satisfy those requirements. Also, as rate setter, California intends to demonstrate how it will assure allowable costs to the rate base though a financial prudency review. The key provisions of financial assurance are: 10 CFR Section 61.61 - This provision requires an applicant to demonstrate its ability to finance licensed activities; 10 CFR Section 61.62 - This provision requires an applicant to provide assurance that sufficient funds will be available for site closure and stabilization; and 10 CFR Section 61.63 - This provision requires an applicant to provide 'a copy of a binding arrangement, such as a lease, between the applicant and the disposal site owner, so that sufficient funds will be available to cover the costs of the institutional control period.' To assist California in its determination of financial assurance compliance to be demonstrated by the applicant for Part 61 requirements, is NUREG guidance document 1199 'Standard Format and Content of a License Application for a Low-Level Radioactive Waste (LLRW) Disposal Facility.' The detailed financial assurance provisions of NUREG 1199 are then embodied in NUREG 1200, 'Standard Review Plant for the Review of a License Application for a LLRW Disposal Facility.'

Changing the Safety and Mission Assurance (S and MA) Paradigm

Science.gov (United States)

Malone, Roy W.; Safie, Fayssal M.

2010-01-01

This slide presentation reviews the change in the work and impact of the Safety and Mission Assurance directorate at Marshall Space Flight Center. It reviews the background and the reasons given for a strong Safety & Mission Assurance presence in all planning for space flight. This was pointed out by the Rogers Commission Report after the Space Challenger accident, by the Columbia Accident Investigation Board (CAIB) and by a 2006 NASA Exploration Safety Study (NESS) Team. The overall objective of the work in this area was to improve and maintain S&MA expertise and skills. Training for this work was improved and the S&MA organization was reorganized. This has resulted in a paradigm shift for NASA's safety efforts, which is described. The presentation then reviews the impact of the new S&MA work in the Ares I design and development.

Initial experience with a novel pre-sign-out quality assurance tool for review of random surgical pathology diagnoses in a subspecialty-based university practice.

Science.gov (United States)

Owens, Scott R; Wiehagen, Luke T; Kelly, Susan M; Piccoli, Anthony L; Lassige, Karen; Yousem, Samuel A; Dhir, Rajiv; Parwani, Anil V

2010-09-01

We recently implemented a novel pre-sign-out quality assurance tool in our subspecialty-based surgical pathology practice at the University of Pittsburgh Medical Center. It randomly selects an adjustable percentage of cases for review by a second pathologist at the time the originating pathologist's electronic signature is entered and requires that the review be completed within 24 hours, before release of the final report. The tool replaced a retrospective audit system and it has been in successful use since January 2009. We report our initial experience for the first 14 months of its service. During this time, the disagreement numbers and levels were similar to those identified using the retrospective system, case turnaround time was not significantly affected, and the number of case amendments generated decreased. The tool is a useful quality assurance instrument and its prospective nature allows for the potential prevention of some serious errors.

Quality-assurance and data management plan for groundwater activities by the U.S. Geological Survey in Kansas, 2014

Science.gov (United States)

Putnam, James E.; Hansen, Cristi V.

2014-01-01

As the Nation’s principle earth-science information agency, the U.S. Geological Survey (USGS) is depended on to collect data of the highest quality. This document is a quality-assurance plan for groundwater activities (GWQAP) of the Kansas Water Science Center. The purpose of this GWQAP is to establish a minimum set of guidelines and practices to be used by the Kansas Water Science Center to ensure quality in groundwater activities. Included within these practices are the assignment of responsibilities for implementing quality-assurance activities in the Kansas Water Science Center and establishment of review procedures needed to ensure the technical quality and reliability of the groundwater products. In addition, this GWQAP is intended to complement quality-assurance plans for surface-water and water-quality activities and similar plans for the Kansas Water Science Center and general project activities throughout the USGS. This document provides the framework for collecting, analyzing, and reporting groundwater data that are quality assured and quality controlled. This GWQAP presents policies directing the collection, processing, analysis, storage, review, and publication of groundwater data. In addition, policies related to organizational responsibilities, training, project planning, and safety are presented. These policies and practices pertain to all groundwater activities conducted by the Kansas Water Science Center, including data-collection programs, interpretive and research projects. This report also includes the data management plan that describes the progression of data management from data collection to archiving and publication.

Quality-assurance and data-management plan for water-quality activities in the Kansas Water Science Center, 2014

Science.gov (United States)

Rasmussen, Teresa J.; Bennett, Trudy J.; Foster, Guy M.; Graham, Jennifer L.; Putnam, James E.

2014-01-01

As the Nation’s largest water, earth, and biological science and civilian mapping information agency, the U.S. Geological Survey is relied on to collect high-quality data, and produce factual and impartial interpretive reports. This quality-assurance and data-management plan provides guidance for water-quality activities conducted by the Kansas Water Science Center. Policies and procedures are documented for activities related to planning, collecting, storing, documenting, tracking, verifying, approving, archiving, and disseminating water-quality data. The policies and procedures described in this plan complement quality-assurance plans for continuous water-quality monitoring, surface-water, and groundwater activities in Kansas.

Technical Excellence and Communication: The Cornerstones for Successful Safety and Mission Assurance Programs

Science.gov (United States)

Malone, Roy W.; Livingston, John M.

2010-01-01

The paper describes the role of technical excellence and communication in the development and maintenance of safety and mission assurance programs. The Marshall Space Flight Center (MSFC) Safety and Mission Assurance (S&MA) organization is used to illustrate philosophies and techniques that strengthen safety and mission assurance efforts and that contribute to healthy and effective organizational cultures. The events and conditions leading to the development of the MSFC S&MA organization are reviewed. Historic issues and concerns are identified. The adverse effects of resource limitations and risk assessment roles are discussed. The structure and functions of the core safety, reliability, and quality assurance functions are presented. The current organization s mission and vision commitments serve as the starting points for the description of the current organization. The goals and objectives are presented that address the criticisms of the predecessor organizations. Additional improvements are presented that address the development of technical excellence and the steps taken to improve communication within the Center, with program customers, and with other Agency S&MA organizations.

Technical Excellence and Communication, the Cornerstones for Successful Safety and Mission Assurance Programs

Science.gov (United States)

Malone, Roy W.; Livingston, John M.

2010-09-01

The paper describes the role of technical excellence and communication in the development and maintenance of safety and mission assurance programs. The Marshall Space Flight Center(MSFC) Safety and Mission Assurance(S&MA) organization is used to illustrate philosophies and techniques that strengthen safety and mission assurance efforts and that contribute to healthy and effective organizational cultures. The events and conditions leading to the development of the MSFC S&MA organization are reviewed. Historic issues and concerns are identified. The adverse effects of resource limitations and risk assessment roles are discussed. The structure and functions of the core safety, reliability, and quality assurance functions are presented. The current organization’s mission and vision commitments serve as the starting points for the description of the current organization. The goals and objectives are presented that address the criticisms of the predecessor organizations. Additional improvements are presented that address the development of technical excellence and the steps taken to improve communication within the Center, with program customers, and with other Agency S&MA organizations.

Quality assurance procedure for assessing mechanical accuracy of a radiation field center in stereotactic radiotherapy

International Nuclear Information System (INIS)

Tatsumi, Daisaku; Ienaga, Akinori; Nakada, Ryosei; Yomoda, Akane; Inoue, Makoto; Ichida, Takao; Hosono, Masako

2012-01-01

Stereotactic radiotherapy requires a quality assurance (QA) program that ensures the mechanical accuracy of a radiation field center. We have proposed a QA method for achieving the above requirement by conducting the Winston Lutz test using an electronic portal image device (EPID). An action limit was defined as three times the standard deviation. Then, the action limits for mean deviations of the radiation field center during collimator rotation, gantry rotation, and couch rotation in clockwise and counterclockwise resulted in 0.11 mm, 0.52 mm, 0.37 mm, and 0.41 mm respectively. Two years after the QA program was launched, the mean deviation of the radiation field center during gantry rotation exceeded the above action limit. Consequently, a mechanical adjustment for the gantry was performed, thereby restoring the accuracy of the radiation field center. A field center shift of 0.5 mm was also observed after a micro multi-leaf collimator was unmounted. (author)

Quality assurance program

International Nuclear Information System (INIS)

Brooks, G.L.

The concept of levels of quality assurance as applied to CANDU-type nuclear power plant components, i.e. maintaining an appropriate cost/benefit ratio, is introduced. The design process itself has quality assurance features by virtue of multi-level review. (E.C.B.)

The RCPA Quality Assurance Program in Dermatopathology: A Retrospective Review.

Science.gov (United States)

Peck, Martyn; Beer, Trevor W; Badrick, Tony; Wood, Benjamin A

2018-03-01

To review the Royal College of Pathologists of Australasia (RCPA) Quality Assurance Program Dermatopathology module from 2005 to 2016 to assess diagnostic performance, changes over time, and areas of diagnostic difficulty. The computerized records of the RCPA Dermatopathology subspecialist module were reviewed. Cases were categorized into groups including nonneoplastic disorders, neoplasms, and cases with multiple diagnoses. The performance of participants over time in each of these categories and in more specific areas (including melanocytic and adnexal neoplasms) was assessed. Cases which showed high rates of discordant responses were specifically reviewed. One hundred sixteen cases circulated over 10 years were evaluated. The overall concordance rate was 77%, with a major discordance rate of 7%. There was a slightly higher concordance rate for neoplasms compared with nonneoplastic lesions (80% vs. 74%). Specific areas associated with lower concordance rates included classification of adnexal tumors and identification of multiple pathologies. A spindle cell nevus of Reed yielded a 40% discordance rate, with most misclassifications indicating melanoma. The RCPA quality assurance program module has circulated a wide range of common and uncommon cases to participants over the 12 years studied, highlighting a low but important rate of major discordant responses. Melanocytic lesions, hematolymphoid infiltrates, adnexal tumors, and identification of multiple pathologies are identified as areas worthy of particular attention in quality improvement activities.

15 CFR 290.8 - Reviews of centers.

Science.gov (United States)

2010-01-01

... TRANSFER OF MANUFACTURING TECHNOLOGY § 290.8 Reviews of centers. (a) Overview. Each Center will be reviewed... involved Center, and Federal officials. An official of NIST shall chair the panel. Each Merit Review Panel... Center be provided by the NIST Manufacturing Technology Centers Program after the sixth year of support...

Software Quality Assurance Audits Guidebooks

Science.gov (United States)

1990-01-01

The growth in cost and importance of software to NASA has caused NASA to address the improvement of software development across the agency. One of the products of this program is a series of guidebooks that define a NASA concept of the assurance processes that are used in software development. The Software Assurance Guidebook, NASA-GB-A201, issued in September, 1989, provides an overall picture of the NASA concepts and practices in software assurance. Second level guidebooks focus on specific activities that fall within the software assurance discipline, and provide more detailed information for the manager and/or practitioner. This is the second level Software Quality Assurance Audits Guidebook that describes software quality assurance audits in a way that is compatible with practices at NASA Centers.

Production and quality assurance automation in the Goddard Space Flight Center Flight Dynamics Facility

Science.gov (United States)

Chapman, K. B.; Cox, C. M.; Thomas, C. W.; Cuevas, O. O.; Beckman, R. M.

1994-01-01

The Flight Dynamics Facility (FDF) at the NASA Goddard Space Flight Center (GSFC) generates numerous products for NASA-supported spacecraft, including the Tracking and Data Relay Satellites (TDRS's), the Hubble Space Telescope (HST), the Extreme Ultraviolet Explorer (EUVE), and the space shuttle. These products include orbit determination data, acquisition data, event scheduling data, and attitude data. In most cases, product generation involves repetitive execution of many programs. The increasing number of missions supported by the FDF has necessitated the use of automated systems to schedule, execute, and quality assure these products. This automation allows the delivery of accurate products in a timely and cost-efficient manner. To be effective, these systems must automate as many repetitive operations as possible and must be flexible enough to meet changing support requirements. The FDF Orbit Determination Task (ODT) has implemented several systems that automate product generation and quality assurance (QA). These systems include the Orbit Production Automation System (OPAS), the New Enhanced Operations Log (NEOLOG), and the Quality Assurance Automation Software (QA Tool). Implementation of these systems has resulted in a significant reduction in required manpower, elimination of shift work and most weekend support, and improved support quality, while incurring minimal development cost. This paper will present an overview of the concepts used and experiences gained from the implementation of these automation systems.

Quality assurance manual: Volume 2, Appendices

Energy Technology Data Exchange (ETDEWEB)

Oijala, J.E.

1988-06-01

This paper contains quality assurance information on departments of the Stanford Linear Accelerator Center. Particular quality assurance policies and standards discussed are on: Mechanical Systems; Klystron and Microwave Department; Electronics Department; Plant Engineering; Accelerator Department; Purchasing; and Experimental Facilities Department. (LSP)

Quality assurance manual: Volume 2, Appendices

International Nuclear Information System (INIS)

Oijala, J.E.

1988-06-01

This paper contains quality assurance information on departments of the Stanford Linear Accelerator Center. Particular quality assurance policies and standards discussed are on: Mechanical Systems; Klystron and Microwave Department; Electronics Department; Plant Engineering; Accelerator Department; Purchasing; and Experimental Facilities Department

State-of-the-art review of quality assurance techniques for vitrified high level waste

International Nuclear Information System (INIS)

Miller, P.L.H.

1984-07-01

Quality assurance is required for certain chemical and physical properties of both the molten glass pour and the solidified glass within the stainless steel container. It is also required to monitor the physical condition of the container lid weld. A review is presented of techniques which are used or which might be adapted for use in the quality assurance of vitrified high level waste. For the most part only non-intrusive methods have been considered, however, some techniques which are not strictly non-intrusive have been reviewed where a non-intrusive technique has not been identified or where there are other advantages associated with the particular technique. In order to identify suitable candidate techniques reference has been made to an extensive literature survey and experts in the fields of nuclear waste technology, glass technology, non-destructive testing, chemical analysis and remote analysis have been contacted. The opinions of manufacturers and users of specific techniques have also been sought. A summary is also given of those techniques which can most readily be applied to the problem of quality assurance for vitrified waste as well as recommendations for further research into techniques which might be adapted to suit this application. (author)

Quality assurance of pre-operative assessment--a review of quality assurance activities related to pre-operative assessment in nine hospitals in The Netherlands

NARCIS (Netherlands)

Klazinga, N. S.; Helsloot, R.

1989-01-01

Pre-operative assessment of patients for surgery is one of the most prevalent topics for quality assurance by peer-review in Dutch hospitals. This article describes the experiences with pre-operative assessment in nine hospitals. It is discussed why preoperative assessment is performed, what tests

7 CFR 652.7 - Quality assurance.

Science.gov (United States)

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Quality assurance. 652.7 Section 652.7 Agriculture... assurance. (a) NRCS will review, in consultation with the Farm Service Agency, as appropriate, the quality... information obtained through its quality assurance process, documentation submitted by the technical service...

Improving patient safety through quality assurance.

Science.gov (United States)

Raab, Stephen S

2006-05-01

Anatomic pathology laboratories use several quality assurance tools to detect errors and to improve patient safety. To review some of the anatomic pathology laboratory patient safety quality assurance practices. Different standards and measures in anatomic pathology quality assurance and patient safety were reviewed. Frequency of anatomic pathology laboratory error, variability in the use of specific quality assurance practices, and use of data for error reduction initiatives. Anatomic pathology error frequencies vary according to the detection method used. Based on secondary review, a College of American Pathologists Q-Probes study showed that the mean laboratory error frequency was 6.7%. A College of American Pathologists Q-Tracks study measuring frozen section discrepancy found that laboratories improved the longer they monitored and shared data. There is a lack of standardization across laboratories even for governmentally mandated quality assurance practices, such as cytologic-histologic correlation. The National Institutes of Health funded a consortium of laboratories to benchmark laboratory error frequencies, perform root cause analysis, and design error reduction initiatives, using quality assurance data. Based on the cytologic-histologic correlation process, these laboratories found an aggregate nongynecologic error frequency of 10.8%. Based on gynecologic error data, the laboratory at my institution used Toyota production system processes to lower gynecologic error frequencies and to improve Papanicolaou test metrics. Laboratory quality assurance practices have been used to track error rates, and laboratories are starting to use these data for error reduction initiatives.

Quality assured health care in certified breast centers and improvement of the prognosis of breast cancer patients.

Science.gov (United States)

Beckmann, Matthias W; Brucker, Cosima; Hanf, Volker; Rauh, Claudia; Bani, Mayada R; Knob, Stefanie; Petsch, Sabrina; Schick, Stefan; Fasching, Peter A; Hartmann, Arndt; Lux, Michael P; Häberle, Lothar

2011-01-01

Increasing effort has been put in the implementation and certification of breast centers in order to establish standardized, quality assured health care for breast cancer patients. The aim of this analysis was to investigate whether patients treated in certified breast centers (CBC) have a favorable prognosis as compared to patients treated outside of certified breast treatment units. The data of 3,940 patients with invasive nonmetastatic breast cancer were analyzed with regard to differences in patient and tumor characteristics and crude overall survival according to diagnosis in or outside CBC in Middle Franconia, Germany. Patient, tumor, and follow-up data were obtained from the clinical cancer registry. Patients in CBC were younger, and had lower disease stages and lower grading. Independent of the effects of these variables on overall survival, being treated at a CBC added to the prediction of overall survival. Patients treated at a CBC had a hazard ratio of 0.70 (95% confidence interval 0.52-0.93) in the adjusted Cox model. Independent from common prognostic factors, diagnosis and treatment of breast cancer at a CBC improves the prognosis of patients. It can be hypothesized that this effect is mediated through quality assured health care provided by the certification process. Copyright © 2011 S. Karger AG, Basel.

Regulatory viewpoint on nuclear fuel quality assurance

International Nuclear Information System (INIS)

Tripp, L.E.

1976-01-01

Considerations of the importance of fuel quality and performance to nuclear safety, ''as low reasonably achievable'' release of radioactive materials in reactor effluents, and past fuel performance problems demonstrate the need for strong regulatory input, review and inspection of nuclear fuel quality assurance programs at all levels. Such a regulatory program is being applied in the United States of America by the US Nuclear Regulatory Commission. Quality assurance requirements are contained within government regulations. Guidance on acceptable methods of implementing portions of the quality assurance program is contained within Regulatory Guides and other NRC documents. Fuel supplier quality assurance program descriptions are reviewed as a part of the reactor licensing process. Inspections of reactor licensee control of their fuel vendors as well as direct inspections of fuel vendor quality assurance programs are conducted on a regularly scheduled basis. (author)

Implementation of a Quality Assurance Review System for the Scalable Development of Online Courses

Science.gov (United States)

Ozdemir, Devrim; Loose, Rich

2014-01-01

With the growing demand for quality online education in the US, developing quality online courses and online programs, and more importantly maintaining this quality, have been an inevitable concern for higher education institutes. Current literature on quality assurance in online education mostly focuses on the development of review models and…

QANU - Quality Assurance Netherlands Universities

DEFF Research Database (Denmark)

Jensen, Henrik Toft; Maria E., Weber; Vyt, André

The Quality Assurance Netherlands Universities (QANU) underwent an ENQA-coordinated external review in 2016. The review was chaired by Henrik Toft Jensen, Research fellow at Roskilde University (RUC), Denmark....

Withdrawal times and associated factors in colonoscopy: a quality assurance multicenter assessment.

Science.gov (United States)

Overholt, Bergein F; Brooks-Belli, Linda; Grace, Michael; Rankin, Kristin; Harrell, Royce; Turyk, Mary; Rosenberg, Fred B; Barish, Robert W; Gilinsky, Norman H

2010-04-01

To evaluate the use and impact of the recommended withdrawal time of at least 6 minutes from the cecum in colonoscopy in multiple gastroenterology endoscopy ambulatory surgery centers serving a wide geographical area. An observational prospective multicenter quality assurance review was conducted in 49 ambulatory surgery centers in 17 states with 315 gastroenterologists. There was no intervention with this quality assessment program as care of patients and the routine of gastroenterologists continued as standard practice. Multivariable analysis was applied to the database to examine factors affecting withdrawal time and polyp detection. There were 15,955 consecutive qualified patients receiving colonoscopies in a designated 4-week period. Gastroenterologists with average withdrawal times of 6 minutes or more in patients with no polyps were 1.8 times more likely to detect 1 or more polyps and had a significantly higher rate (Pquality assurance assessment from standard colonoscopy practices of 315 gastroenterologists in 49 endoscopic ambulatory surgery centers serving a wide geographical area provides support for the merits of a colonoscopy withdrawal time from the cecum of 6 minutes or more to improve the detection of polyps.

Putting women at the center: a review of Indian policy to address person-centered care in maternal and newborn health, family planning and abortion

Directory of Open Access Journals (Sweden)

Aradhana Srivastava

2017-07-01

Full Text Available Abstract Background Person-centered care is a critical component of quality care, essential to enable treatment adherence, and maximize health outcomes. Improving the quality of health services is a key strategy to achieve the new global target of zero preventable maternal deaths by 2030. Recognizing this, the Government of India has in the last decade initiated a number of strategies to address quality of care in health and family welfare services. Methods We conducted a policy review of quality improvement strategies in India from 2005 to 15, covering three critical areas– maternal and newborn health, family planning, and abortion (MNHFP + A. Based on Walt and Gilson’s policy triangle framework, we analyzed the extent to which policies incorporated person-centered care, while identifying unaddressed issues. Data was sourced from Government of India websites, scientific and grey literature databases. Results Twenty-two national policy documents, comprising two policy statements and 20 implementation guidelines of specific schemes were included in the review. Quality improvement strategies span infrastructure, commodities, human resources, competencies, and accountability that are driving quality assurance in MNHFP + A services. However, several implementation challenges have affected compliance with person-centered care, thereby affecting utilization and outcomes. Conclusion Focus on person-centered care in Indian MNHFP + A policy has increased in recent years. Nevertheless, some aspects must still be strengthened, such as positive interpersonal behavior, information sharing and promptness of care. Implementation can be improved through better provider training, patient feedback and monitoring mechanisms. Moreover, unless persisting structural challenges are addressed implementation of person-centered care in facilities will not be effective.

The World Optical Depth Research and Calibration Center (WORCC) quality assurance and quality control of GAW-PFR AOD measurements

Science.gov (United States)

Kazadzis, Stelios; Kouremeti, Natalia; Nyeki, Stephan; Gröbner, Julian; Wehrli, Christoph

2018-02-01

The World Optical Depth Research Calibration Center (WORCC) is a section within the World Radiation Center at Physikalisches-Meteorologisches Observatorium (PMOD/WRC), Davos, Switzerland, established after the recommendations of the World Meteorological Organization for calibration of aerosol optical depth (AOD)-related Sun photometers. WORCC is mandated to develop new methods for instrument calibration, to initiate homogenization activities among different AOD networks and to run a network (GAW-PFR) of Sun photometers. In this work we describe the calibration hierarchy and methods used under WORCC and the basic procedures, tests and processing techniques in order to ensure the quality assurance and quality control of the AOD-retrieved data.

RAVEN Quality Assurance Activities

Energy Technology Data Exchange (ETDEWEB)

Cogliati, Joshua Joseph [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-09-01

This report discusses the quality assurance activities needed to raise the Quality Level of Risk Analysis in a Virtual Environment (RAVEN) from Quality Level 3 to Quality Level 2. This report also describes the general RAVEN quality assurance activities. For improving the quality, reviews of code changes have been instituted, more parts of testing have been automated, and improved packaging has been created. For upgrading the quality level, requirements have been created and the workflow has been improved.

The NASA Commercial Crew Program (CCP) Mission Assurance Process

Science.gov (United States)

Canfield, Amy

2016-01-01

In 2010, NASA established the Commercial Crew Program in order to provide human access to the International Space Station and low earth orbit via the commercial (non-governmental) sector. A particular challenge to NASA has been how to determine the commercial providers transportation system complies with Programmatic safety requirements. The process used in this determination is the Safety Technical Review Board which reviews and approves provider submitted Hazard Reports. One significant product of the review is a set of hazard control verifications. In past NASA programs, 100 percent of these safety critical verifications were typically confirmed by NASA. The traditional Safety and Mission Assurance (SMA) model does not support the nature of the Commercial Crew Program. To that end, NASA SMA is implementing a Risk Based Assurance (RBA) process to determine which hazard control verifications require NASA authentication. Additionally, a Shared Assurance Model is also being developed to efficiently use the available resources to execute the verifications. This paper will describe the evolution of the CCP Mission Assurance process from the beginning of the Program to its current incarnation. Topics to be covered include a short history of the CCP; the development of the Programmatic mission assurance requirements; the current safety review process; a description of the RBA process and its products and ending with a description of the Shared Assurance Model.

Project T100 -- Hazardous Materials Management and Emergency Response Training Center (HAMMER)

International Nuclear Information System (INIS)

Norton, C.E.

1994-01-01

The scope of this Quality Assurance Program Plan (QAPP) is to provide a system of Quality Assurance reviews and verifications on the design and construction of the Hazardous Materials Management and Emergency Response (HAMMER) Training Center, project 95L-EWT-100 at Hanford. The reviews and verifications will be on activities associated with design, procurement, and construction of the HAMMER project which includes, but is not limited to earthwork, placement of concrete, laying of rail, drilling of wells, water and sewer line fabrication and installation, communications systems, fire protection/detection systems, line tie-ins, building and mock-up (prop) construction, electrical, instrumentation, pump and valves and special coatings

Quality assurance in materials and construction

Science.gov (United States)

2007-06-01

This review is a product of the FHWA 2006, National Review Program (NRP). Quality Assurance (QA) was selected for review in 2006 because the program was ranked as one of the top five areas of interest for review by FHWA. Over the last 10 years an ave...

[Quality Assurance in Sociomedical Evaluation by Peer Review: A Pilot Project of the German Statutory Pension Insurance].

Science.gov (United States)

Strahl, A; Gerlich, C; Wolf, H-D; Gehrke, J; Müller-Garnn, A; Vogel, H

2016-03-01

The sociomedical evaluation by the German Pension Insurance serves the purpose of determining entitlement to disability pensions. A quality assurance concept for the sociomedical evaluation was developed, which is based on a peer Review process. Peer review is an established process of external quality assurance in health care. The review is based on a hierarchically constructed manual that was evaluated in this pilot project. The database consists of 260 medical reports for disability pension of 12 pension insurance agencies. 771 reviews from 19 peers were included in the evaluation of the inter-rater reliability. Kendall's coefficient of concordance W for more than 2 raters is used as primary measure of inter-rater reliability. Reliability appeared to be heterogeneous. Kendalls W varies for the particular criteria from 0.09 to 0.88 and reached for primary criterion reproducibility a value of 0.37. The reliability of the manual seemed acceptable in the context of existing research data and is in line with existing peer review research outcomes. Nevertheless, the concordance is limited and requires optimisation. Starting points for improvement can be seen in a systematic training and regular user meetings of the peers involved. © Georg Thieme Verlag KG Stuttgart · New York.

Quality assurance in the 22991 EORTC ROG trial in localized prostate cancer: Dummy run and individual case review

International Nuclear Information System (INIS)

Matzinger, Oscar; Poortmans, Philip; Giraud, Jean-Yves; Maingon, Philippe; Budiharto, Tom; Bergh, Alfons C.M. van den; Davis, J. Bernard; Musat, Elena; Ataman, Fatma; Huyskens, Dominique P.; Gulyban, Akos; Bolla, Michel

2009-01-01

Introduction: EORTC trial 22991 was designed to evaluate the addition of concomitant and adjuvant short-term hormonal treatments to curative radiotherapy in terms of disease-free survival for patients with intermediate risk localized prostate cancer. In order to assess the compliance to the 3D conformal radiotherapy protocol guidelines, all participating centres were requested to participate in a dummy run procedure. An individual case review was performed for the largest recruiting centres as well. Materials and methods: CT-data of an eligible prostate cancer patient were sent to 30 centres including a description of the clinical case. The investigator was requested to delineate the volumes of interest and to perform treatment planning according to the protocol. Thereafter, the investigators of the 12 most actively recruiting centres were requested to provide data on five randomly selected patients for an individual case review. Results: Volume delineation varied significantly between investigators. Dose constraints for organs at risk (rectum, bladder, hips) were difficult to meet. In the individual case review, no major protocol deviations were observed, but a number of dose reporting problems were documented for centres using IMRT. Conclusions: Overall, results of this quality assurance program were satisfactory. The efficacy of the combination of a dummy run procedure with an individual case review is confirmed in this study, as none of the evaluated patient files harboured a major protocol deviation. Quality assurance remains a very important tool in radiotherapy to increase the reliability of the trial results. Special attention should be given when designing quality assurance programs for more complex irradiation techniques

Quality assurance requirements in various codes and standards

International Nuclear Information System (INIS)

Shaaban, H.I.; EL-Sayed, A.; Aly, A.E.

1987-01-01

The quality assurance requirements in various countries and according to various international codes and standards are presented, compared and critically discussed. Cases of developing countries are also discussed, and the use of IAEA code of practice and other codes for quality assurance in these countries is reviewed. Recommendations are made regarding the quality assurance system to be applied for Egypt's nuclear power plants

Actions Needed to Ensure Scientific and Technical Information is Adequately Reviewed at Goddard Space Flight Center, Johnson Space Center, Langley Research Center, and Marshall Space Flight Center

Science.gov (United States)

2008-01-01

This audit was initiated in response to a hotline complaint regarding the review, approval, and release of scientific and technical information (STI) at Johnson Space Center. The complainant alleged that Johnson personnel conducting export control reviews of STI were not fully qualified to conduct those reviews and that the reviews often did not occur until after the STI had been publicly released. NASA guidance requires that STI, defined as the results of basic and applied scientific, technical, and related engineering research and development, undergo certain reviews prior to being released outside of NASA or to audiences that include foreign nationals. The process includes technical, national security, export control, copyright, and trade secret (e.g., proprietary data) reviews. The review process was designed to preclude the inappropriate dissemination of sensitive information while ensuring that NASA complies with a requirement of the National Aeronautics and Space Act of 1958 (the Space Act)1 to provide for the widest practicable and appropriate dissemination of information resulting from NASA research activities. We focused our audit on evaluating the STI review process: specifically, determining whether the roles and responsibilities for the review, approval, and release of STI were adequately defined and documented in NASA and Center-level guidance and whether that guidance was effectively implemented at Goddard Space Flight Center, Johnson Space Center, Langley Research Center, and Marshall Space Flight Center. Johnson was included in the review because it was the source of the initial complaint, and Goddard, Langley, and Marshall were included because those Centers consistently produce significant amounts of STI.

Quality assurance in ionizing radiation application

International Nuclear Information System (INIS)

Rastkhah; Nasser.

1995-01-01

Quality assurance is a mean for controlling all the activities within an organization which affect the quality of the product or service. A series of international standards have been prepared which incorporate the accumulated knowledge and provide guidance on what activities within an organization should be controlled. A proposal on a quality assurance system to be implemented in ionizing radiation application centers is the primary concern of Atomic Energy Organization of Iran is represented. The Objectives were identification of quality related problems ;Comply with national and international requirements ;Controlling all activities within an organization which affects the quality and assurance of maintaining the quality within organization. In performing protection measures, risk, cost, benefit consideration, cause of problems and the classic solution are summarized in four chapters

75 FR 36662 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-06-28

... for Scientific Review Special Emphasis Panel; Review of the Mass Spectrometry Research Center. Date... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; RFA Panel...

Quality assurance in radiology: peer review and peer feedback

International Nuclear Information System (INIS)

Strickland, N.H.

2015-01-01

Peer review in radiology means an assessment of the accuracy of a report issued by another radiologist. Inevitably, this involves a judgement opinion from the reviewing radiologist. Peer feedback is the means by which any form of peer review is communicated back to the original author of the report. This article defines terms, discusses the current status, identifies problems, and provides some recommendations as to the way forward, concentrating upon the software requirements for efficient peer review and peer feedback of reported imaging studies. Radiologists undertake routine peer review in their everyday clinical practice, particularly when reporting and preparing for multidisciplinary team meetings. More formal peer review of reported imaging studies has been advocated as a quality assurance measure to promote good clinical practice. It is also a way of assessing the competency of reporting radiologists referred for investigation to bodies such as the General Medical Council (GMC). The literature shows, firstly, that there is a very wide reported range of discrepancy rates in many studies, which have used a variety of non-comparable methodologies; and secondly, that applying scoring systems in formal peer review is often meaningless, unhelpful, and can even be detrimental. There is currently a lack of electronic peer feedback system software on the market to inform radiologists of any review of their work that has occurred or to provide them with clinical outcome information on cases they have previously reported. Learning opportunities are therefore missed. Radiologists should actively engage with the medical informatics industry to design optimal peer review and feedback software with features to meet their needs. Such a system should be easy to use, be fully integrated with the radiological information and picture archiving systems used clinically, and contain a free-text comment box, without a numerical scoring system. It should form a temporary record

Quality Assurance Tracking System - R7 (QATS-R7)

Data.gov (United States)

U.S. Environmental Protection Agency — This is metadata documentation for the Quality Assurance Tracking System - R7, an EPA Region 7 resource that tracks information on quality assurance reviews. Also...

NRC assessment of the high-level waste repository quality assurance program

International Nuclear Information System (INIS)

Kennedy, J.E.

1987-01-01

As part of its licensing responsibilities, the NRC is independently reviewing the DOE quality assurance program applied to the site characterization phase activities. Data collected and other information generated during this phase of the program will ultimately be used in a license application to demonstrate the suitability of one site for long-term isolation of waste. They must therefore fall under the quality assurance program to provide confidence in their adequacy. This NRC review consists of three main activities: development of staff guidance on quality assurance measures appropriate for site characterization activities; review of DOE QA plans and procedures; and audits and other reviews of the implementation of the program

The effective quality assurance for image guided device using the AMC G-Box

Energy Technology Data Exchange (ETDEWEB)

Kim, Chong Mi [Dept. of Radiation Oncology, Asan Medical Center, Seoul (Korea, Republic of)

2014-12-15

According to the rapid increase recently in image-guided radiation therapy, It is necessary to control of the image guidance system completely. In particular for the main subject to the accuracy of image guided radiation therapy device to be done essentially the quality assurance. We made efficient phantom in AMC for the management of the accurate and efficient. By setting up of five very important as a quality assurance inventory of the Image guidance system, we made (AMC G-Box) phantom for quality assurance efficient and accurate. Quality assurance list were the Iso-center align, the real measurement, the center align of four direction, the accuracy of table movement and the reproducibility of Hounsfield Unit. The rectangular phantom; acrylic with a thickness of 1 cm to 10 cm × 10 cm × 10 cm was inserted the three materials with different densities respectively for measure the CBCT HU. The phantom was to perform a check of consistency centered by creating a marker that indicates the position of the center fixed. By performing the quality assurance using the phantom of existing, comparing the resulting value to the different resulting value using the AMC G-Box, experiment was analyzed time and problems. Therapy equipment was used Varian device. It was measured twice at 1-week intervals. When implemented quality assurance of an image guidance system using AMC G-Box and a phantom existing has been completed, the quality assurance result is similar in 0.2 mm ± 0.1. In the case of the conventional method, it was 45 minutes at 30 minutes. When using AMC G-Box, it takes 20 minutes 15 minutes, and declined to 50% of the time. The consistency and accurate of image guidance system tend to decline using device. Therefore, We need to perform thoroughly on the quality assurance related. It needs to be checked daily to consistency check especially. When using the AMC G-Box, It is possible to enhance the accuracy of the patient care and equipment efficiently performing

FFTF Work Control Center

International Nuclear Information System (INIS)

Talbot, M.D.

1986-01-01

A centralized Work Control Center (WCC) is responsible for assuring that maintenance and modification of the Fast Flux Test Facility (FFTF) is performed in accordance with written procedures that ensure design integrity, personnel and public safety, and equipment and system availability for the computerized Master Information Data Acquisition System (MIDAS). Each maintenance task is logged into MIDAS from a Work Request from that has been reviewed and prioritized by the WCC. Thereafter, MIDAS is used to track schedule, manpower and material requirements; authorize field work; and close out the maintenance activity

12: Assuring the quality of critical software

International Nuclear Information System (INIS)

Jacky, J.; Kalet, I.

1987-01-01

The authors recommend quality assurance procedures for radiation therapy software. Software quality assurance deals with preventing, detecting and repairing programming errors. Error detection difficulties are most severe in computer-based control systems, for example therapy machine control systems, because it may be impossible for users to confirm correct operation while treatments are in progress, or to intervene if things go wrong. Software quality assurance techniques observed in other industries in which public safety is at risk are reviewed. In some of these industries software must be approved or certified before it can be used. Approval is subject to technical reviews and audits by experts other than the program authors. The main obstacles to adoption of these techniques in the radiation therapy field are costs, lack of familiarity and doubts regarding efficacy. 18 refs

NASA Goddard Space Flight Center Supply Chain Management Program

Science.gov (United States)

Kelly, Michael P.

2011-01-01

This slide presentation reviews the working of the Supplier Assessment Program at NASA Goddard Space Flight Center. The program supports many GSFC projects to ensure suppliers are aware of and are following the contractual requirements, to provide an independent assessment of the suppliers' processes, and provide suppliers' safety and mission assurance organizations information to make the changes within their organization.

Quality assurance manual for the development of digital systems

International Nuclear Information System (INIS)

Lee, Cheol Kwon; Kwon, Kee Choon; You, Young Eun; Kim, Kwan Hyun; Park, Jung Woo; Park, Chan Seok

2001-12-01

A digital safety system is being developed by three companies under the Korea Nuclear I and C System R and D Program. This Quality Assurance Manual (QAM) is written to ensure the safety and reliability of the system and to meet the regulatory requirements associated with quality assurance. This QAM describes eighteen elements of quality assurance criteria required for the development of the system, which are coincident with the criteria specified in Nuclear Energy Laws and Enforcement Regulations of Nuclear Energy Laws and 10CFR50 Appendix B. This QAM is submitted to the regulatory body with other documents related to the quality assurance activities performed during the system development. And its safety, validity and fulfillment are reviewed and audited in the review process of topical report of the digital safety system

Ontario's Quality Assurance Framework: A Critical Response

Science.gov (United States)

Heap, James

2013-01-01

Ontario's Quality Assurance Framework (QAF) is reviewed and found not to meet all five criteria proposed for a strong quality assurance system focused on student learning. The QAF requires a statement of student learning outcomes and a method and means of assessing those outcomes, but it does not require that data on achievement of intended…

Telemedicine spirometry training and quality assurance program in primary care centers of a public health system.

Science.gov (United States)

Marina Malanda, Nuria; López de Santa María, Elena; Gutiérrez, Asunción; Bayón, Juan Carlos; Garcia, Larraitz; Gáldiz, Juan B

2014-04-01

Forced spirometry is essential for diagnosing respiratory diseases and is widely used across levels of care. However, several studies have shown that spirometry quality in primary care is not ideal, with risks of misdiagnosis. Our objective was to assess the feasibility and performance of a telemedicine-based training and quality assurance program for forced spirometry in primary care. The two phases included (1) a 9-month pilot study involving 15 centers, in which spirometry tests were assessed by the Basque Office for Health Technology Assessment, and (2) the introduction of the program to all centers in the Public Basque Health Service. Technicians first received 4 h of training, and, subsequently, they sent all tests to the reference laboratory using the program. Quality assessment was performed in accordance with clinical guidelines (A and B, good; C-F, poor). In the first phase, 1,894 spirometry tests were assessed, showing an improvement in quality: acceptable quality tests increased from 57% at the beginning to 78% after 6 months and 83% after 9 months (passessed after the inclusion of 36 additional centers, maintaining the positive trend (61%, 87%, and 84% at the same time points; pquality of spirometry tests improved in all centers. (2) The program provides a tool for transferring data that allows monitoring of its quality and training of technicians who perform the tests. (3) This approach is useful for improving spirometry quality in the routine practice of a public health system.

DoD Nuclear Weapons Personnel Reliability Assurance

Science.gov (United States)

2016-04-27

systems, positive control material (PCM) and equipment, and special nuclear material (SNM) and subject to a nuclear weapons personnel reliability...assurance implementation guidance for consistency and compliance with this issuance. c. Conducts programmatic reviews, manages audits , and directs...personnel reliability assurance education and training materials . 2.4. ASSISTANT SECRETARY OF DEFENSE FOR HEALTH AFFAIRS (ASD(HA)). Under the authority

Application of Quality Assurance to MCandA systems

International Nuclear Information System (INIS)

Skinner, A.J.; Delvin, W.L.

1986-01-01

Quality Assurance has been applied to the MCandA function within the Department of Energy's Savannah River Operations Office. It was applied to both the activities used to operate the MCandA Branch and the activities used by the Branch to overview the MCandA function of DOE/SR's contractor. In this paper, the principles of quality assurance are reviewed and their application at DOE/SR is discussed. In addition, quality assurance can be applied to the broader MCandA functions required of those facilities producing, using, and handling nuclear materials. Application of quality assurance to those broader functions is also discussed

Quality assurance in radiology: peer review and peer feedback.

Science.gov (United States)

Strickland, N H

2015-11-01

Peer review in radiology means an assessment of the accuracy of a report issued by another radiologist. Inevitably, this involves a judgement opinion from the reviewing radiologist. Peer feedback is the means by which any form of peer review is communicated back to the original author of the report. This article defines terms, discusses the current status, identifies problems, and provides some recommendations as to the way forward, concentrating upon the software requirements for efficient peer review and peer feedback of reported imaging studies. Radiologists undertake routine peer review in their everyday clinical practice, particularly when reporting and preparing for multidisciplinary team meetings. More formal peer review of reported imaging studies has been advocated as a quality assurance measure to promote good clinical practice. It is also a way of assessing the competency of reporting radiologists referred for investigation to bodies such as the General Medical Council (GMC). The literature shows, firstly, that there is a very wide reported range of discrepancy rates in many studies, which have used a variety of non-comparable methodologies; and secondly, that applying scoring systems in formal peer review is often meaningless, unhelpful, and can even be detrimental. There is currently a lack of electronic peer feedback system software on the market to inform radiologists of any review of their work that has occurred or to provide them with clinical outcome information on cases they have previously reported. Learning opportunities are therefore missed. Radiologists should actively engage with the medical informatics industry to design optimal peer review and feedback software with features to meet their needs. Such a system should be easy to use, be fully integrated with the radiological information and picture archiving systems used clinically, and contain a free-text comment box, without a numerical scoring system. It should form a temporary record

The Marshall Islands radioassay quality assurance program. An overview

International Nuclear Information System (INIS)

Hamilton, T.F.; Robison, W.L.; Kehl, S.; Stoker, A.C.; Conrado, C.L.

2000-01-01

An extensive quality assurance program to provide high quality data and assessments in support of the Marshall Islands Dose Assessment and Radioecology Program has been developed the Lawrence Livermore National Laboratory. Quality assurance objectives begin with the premise of providing integrated and cost-effective program support (to meet wide-ranging programmatic needs, scientific peer review, and build public confidence) and continue through from design and implementation of large-scale field programs, sampling and sample preparation, radiometric and chemical analyses, documentation of quality assurance/quality control practices, exposure assessments, and dose/risk assessments until publication. The basic structure of the radioassay quality assurance/quality control program can be divided into four essential elements: (1) sample and data integrity control, (2) instrument validation and calibration, (3) method performance testing, validation, development and documentation, and (4) periodic peer review and on-site assessments. While the quality assurance objectives are tailored towards a single research program and the evaluation of major exposure pathways/critical radionuclides pertinent to the Marshall Islands, quality assurance practices that are consistent with proposed criteria designed for laboratory accreditation were attempted to be developed. (author)

Tritium systems test assembly quality assurance program

International Nuclear Information System (INIS)

Kerstiens, F.L.; Wilhelm, R.C.

1986-07-01

A quality assurance program should establish the planned and systematic actions necessary to provide adequate confidence that fusion facilities and their subsystems will perform satisfactorily in service. The Tritium Systems Test Assembly (TSTA) Quality Assurance Program has been designed to assure that the designs, tests, data, and interpretive reports developed at TSTA are valid, accurate, and consistent with formally specified procedures and reviews. The quality consideration in all TSTA activities is directed toward the early detection of quality problems, coupled with timely and positive disposition and corrective action

Quality assurance and quality control in mammography: A review

International Nuclear Information System (INIS)

BenComo, Jose A.

2000-01-01

A mammogram is among the most technically demanding radiographic procedures. The early detection of breast cancer relies on the radiologist's ability to perceive subtle changes in the image that are only perceptible with high-quality imaging. Early detection of breast cancer is only as reliable as the mammogram with which a diagnosis is made, and a mammogram is only as accurate as the system that produces it. A quality assurance (QA) program maximizes the likelihood that the mammographic images will provide adequate diagnostic information for the least possible radiation exposure and cost to the patient. The QA program monitors each phase of operation of the imaging facility beginning with the request for an examination and ending with the interpretation of the referring physician and ensures that the imaging equipment used for the examination will yield the information desired. Because image quality is the most important technical aspect of mammography, this review summarizes the most important QA and quality control issues

78 FR 4419 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-01-22

...: Center for Scientific Review Special Emphasis Panel, Biomedical Imaging and Engineering Area Review. Date... . Name of Committee: Center for Scientific Review Special Emphasis Panel, Member Conflict: Nanotechnology...

78 FR 30303 - National Contact Center; Submission for OMB Review; National Contact Center Customer Evaluation...

Science.gov (United States)

2013-05-22

...] National Contact Center; Submission for OMB Review; National Contact Center Customer Evaluation Survey... regarding the National Contact Center customer evaluation surveys. In this request, the previously approved... customer service levels to those of private industry contact centers. A notice was published in the Federal...

Elements of quality assurance in environmental surveillance

International Nuclear Information System (INIS)

Johnson, L.J.

1975-01-01

Qualities of an environmental surveillance program requiring control or assurance are reviewed. Requirements of accuracy, reproducibility, sensitivity, acceptability, and time and cost effectiveness are qualities discussed. The controls applicable to sample collection, handling, chemical analysis, measurement and data presentation are identified and discussed as they pertain to environmental monitoring. Quality assurance program recommendations for developing and reporting environmental surveillance data are provided

Quality assurance study for dosimetry of Radiation Therapy equipment in Saudi Arabia

International Nuclear Information System (INIS)

Al-Mokhlef, Jazi M.; Nabaz, Noori

2003-01-01

International standards address the accuracy of dose delivery for radiation therapy machines as well as quality assurance and staffing levels for radiation therapy centers. We performed absolute calibrations of gamma ,X-ray and electron radiotherapy beams in all radiation therapy centers in Saudi Arabia. We also assessed quality assurance and staffing levels Dosimetric measurements were made with a portable dosimetry system, which consisted of a calibrated Farmer ionization chamber and an electrometer, small water phantom, barometer and thermometer. Differences between the measured and the expected output (c Gy/MU or c Gy/min) were found to be in the range of -11%+5%. About 17% of radiotherapy beams were not within the acceptable tolerance level (+/-3%). Quality assurance in some radiation centers was poor and staffing levels were inadequate. We found poor compliance with internationally accepted tolerance levels for dose calibration of radiotherapy beams at radiation therapy centers in Saudi Arabia. Analysis of medical physics staffing revealed severe discrepancies from those recommended by international guidelines .We recommend that radiation therapy centers be adequately staffed with qualified medical physics personnel and that periodic audit programs be required a governmental body. (author)

Quality assurance manual: Volume 1

International Nuclear Information System (INIS)

Oijala, J.E.

1988-06-01

Stanford Linear Accelerator Center (SLAC) is a DOE-supported research facility that carries out experimental and theoretical research in high energy physics and developmental work in new techniques for particle acceleration and experimental instrumentation. The purpose of this manual is to describe SLAC quality assurance policies and practices in various parts of the Laboratory

Review process and quality assurance in the EBR-II probabilistic risk assessment

International Nuclear Information System (INIS)

Roglans, J.; Hill, D.J.; Ragland, W.A.

1992-01-01

A Probabilistic Risk Assessment (PRA) of the Experimental Breeder Reactor II (EBR-II), a Department of Energy (DOE) Category A reactor, has recently been completed at Argonne National Laboratory (ANL). Within the scope of the ANL QA Programs, a QA Plan specifically for the EBR-II PRA was developed. The QA Plan covered all aspects of the PRA development, with emphasis on the procedures for document and software control, and the internal and external review process. The effort spent in the quality assurance tasks for the EBR-II PRA has reciprocated by providing acceptance of the work and confidence in the quality of the results

Quality assurance in plant engineering

International Nuclear Information System (INIS)

Ohsumi, Morimichi

1977-01-01

Quality assurance is defined as the intentional and systematic activity carried out to obtain such reliability that the functions of nuclear power generating plants are demonstrated during the plant operation, and the section in charge has the role to organize, adjust and communicate so that the related sections can work smoothly. There are many documents concerning the quality assurance, such as quality assurance basic program, quality assurance manual, quality control plan and its manual and many specifications, etc. The content of the quality assurance is different for every step of plant planning such as at inquiry and order receiving, and prior to manufacturing, for example, inspection specification being decided for the material and the welded parts of classified pipings at the step of order receiving. Document management, engineering schedule and the custody of quality records are also quality assurance activities. Design management is controlled step by step; plant planning including safety analysis, overall layout plan, conceptual design of buildings, aseismatic design guide, heat balance and so on, system design mainly with system description, piping design including piping specification, standard dimensions of edge preparation, piping and valve lists, inspection manual, etc., detailed design, standardization of piping and design review, etc. are explained. The management of the intermediate between soft and hard parts consists of the quality check for material manufacturers and shipment inspection, etc. (Nakai, Y.)

Quality assurance standards of nuclear equipment and international cooperation

International Nuclear Information System (INIS)

Savanger, J.M.

1983-01-01

This paper analyses the quality assurance system; it briefly defines the meaning of this concept and assesses the status of quality assurance in France. The author also reviews the problems and difficulties encountered in the setting up of this system. (NEA) [fr

The IAEA Code of Practice on quality assurance, and quality assurance requirements and practices in Member States

International Nuclear Information System (INIS)

Raisic, N.

1982-01-01

The IAEA Code of Practice on Quality Assurance for Safety in Nuclear Power Plants and the corresponding Safety Guides are reviewed and compared with quality assurance (QA) practices in the IAEA Member States. The QA requirements stipulated by the Code place on the nuclear power plant owner the responsibility to establish an overall QA programme for the plant. In selecting the QA programme level for specific activities, the Code allows of a flexible approach but does not specify gradation in programme requirements. The Code is placing the burden of quality-achieving and quality-assuring functions on the task-performing organizations, namely the designers, manufacturers, constructors and plant operators. The plant owner provides for the management of the overall QA programme, surveillance of activities and verifications of the effectiveness of the constituent programmes of all project participants through programme audits and evaluations. The Code and the supporting Safety Guides are consistent with existing QA practices in Member States. However, certain differences exist, which are mainly expressed in the different QA functions assigned to the various organizations participating in the overall QA programme. Also, some Member States place more emphasis on redundant verification activities than on quality-achieving functions. Tendencies are also identified to grade the QA requirements in respect of items and activities, in accordance with some pre-established criteria. In an annex to the paper, QA practices in Member States participating in the Agency's Technical Review Committee on Quality Assurance (TRC-QA) are reviewed, indicating their similarities to and differences from the Code

[Quality assurance concepts in intensive care medicine].

Science.gov (United States)

Brinkmann, A; Braun, J P; Riessen, R; Dubb, R; Kaltwasser, A; Bingold, T M

2015-11-01

Intensive care medicine (ICM) is characterized by a high degree of complexity and requires intense communication and collaboration on interdisciplinary and multiprofessional levels. In order to achieve good quality of care in this environment and to prevent errors, a proactive quality and error management as well as a structured quality assurance system are essential. Since the early 1990s, German intensive care societies have developed concepts for quality management and assurance in ICM. In 2006, intensive care networks were founded in different states to support the implementation of evidence-based knowledge into clinical routine and to improve medical outcome, efficacy, and efficiency in ICM. Current instruments and concepts of quality assurance in German ICM include core intensive care data from the data registry DIVI REVERSI, quality indicators, peer review in intensive care, IQM peer review, and various certification processes. The first version of German ICM quality indicators was published in 2010 by an interdisciplinary and interprofessional expert commission. Key figures, indicators, and national benchmarks are intended to describe the quality of structures, processes, and outcomes in intensive care. Many of the quality assurance tools have proved to be useful in clinical practice, but nationwide implementation still can be improved.

Quality assurance in the nuclear test program

International Nuclear Information System (INIS)

Shearer, J.N.

1979-01-01

In February 1979 Test Program laid the ground work for a new quality assurance structure. The new approach was based on the findings and recommendations of the Ad Hoc QA Program Review panel, which are summarized in this report. The new structure places the responsibility for quality assurance in the hands of the line organizations, both in the programmatic and functional elements of the LLL matrix

75 FR 6032 - National Contact Center; Submission for OMB Review; National Contact Center Customer Evaluation...

Science.gov (United States)

2010-02-05

... for OMB Review; National Contact Center Customer Evaluation Survey AGENCY: Citizen Services and Communications, Federal Consumer Information Center, GSA. ACTION: Notice of request for comments regarding a... collection requirement regarding the National Contact Center customer evaluation survey. A request for public...

Development and status of data quality assurance program at NASA Langley research center: Toward national standards

Science.gov (United States)

Hemsch, Michael J.

1996-01-01

As part of a continuing effort to re-engineer the wind tunnel testing process, a comprehensive data quality assurance program is being established at NASA Langley Research Center (LaRC). The ultimate goal of the program is routing provision of tunnel-to-tunnel reproducibility with total uncertainty levels acceptable for test and evaluation of civilian transports. The operational elements for reaching such levels of reproducibility are: (1) statistical control, which provides long term measurement uncertainty predictability and a base for continuous improvement, (2) measurement uncertainty prediction, which provides test designs that can meet data quality expectations with the system's predictable variation, and (3) national standards, which provide a means for resolving tunnel-to-tunnel differences. The paper presents the LaRC design for the program and discusses the process of implementation.

A strategy to develop and implement Canadian standards for quality assurance in radiation therapy

International Nuclear Information System (INIS)

1999-05-01

In Canada, the Atomic Energy Control Board (AECB) regulates the limits of radiation exposure to the public and to workers in industry. In 1993, it discussed the fact that the safety of radiation therapy patients who receive medical exposures is not regulated [AE93]. The Group of Medical Advisors (GMA) to the AECB initiated a research contract to review quality assurance in Canadian radiation oncology centres and nuclear medicine departments. The review [MA95] revealed that the level of quality assurance in radiation therapy facilities varied across the country. As a result, the GMA undertook its own review of quality assurance in radiation therapy centres and made recommendations on how to achieve a uniform national system [MA98]. In response to the GMA report, the President of the AECB formed a Joint Working Group (JWG-11) to propose how Canadian Standards for Quality Assurance in Radiation Therapy could be developed and implemented. These national standards for quality assurance will serve as a common basis for establishing and evaluating quality assurance programs at individual radiation therapy centres. These standards should address the structure of quality assurance programs and quality assurance for radiation therapy equipment, personnel, and procedures. (author)

42 CFR 441.352 - State assurances.

Science.gov (United States)

2010-10-01

... expended for home and community-based services. The State must provide for an independent audit f its... 42 Public Health 4 2010-10-01 2010-10-01 false State assurances. 441.352 Section 441.352 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

BUILDING "BRIDGES" WITH QUALITY ASSURANCE

Science.gov (United States)

The papr describes how, rather than building "bridges" across centuries, quality assurance (QA) personnel have the opportunity to build bridges across technical disciplines, between public and private organizations, and between different QA groups. As reviewers and auditors of a...

Level of evidence for reasonable assurance guides to prediction

International Nuclear Information System (INIS)

Schweitzer, D.G.; Sastre, C.

1987-04-01

Over the past years, the DOE Contractors have produced a great deal of work that has been extensively reviewed and criticized by the Nuclear Regulatory Commission (NRC), the Materials Review Board (MRB) of the DOE, the Advisory Committee on Reactor Safeguards (ACRS), and the technical support group at Brookhaven National Laboratory (BNL). Common aspects of the reviews and criticisms have provided information on the level of evidence required by the scientific community to defend performance claims. Important indicators of the type of evidence that the NRC will require for favorable decisions of reasonable assurance also can be obtained from 10 CFR 60 and its rationale, from NRC guides and Technical Position papers, from past reviews of the DOE programs by NRC Contractors, and from the use of reasonable assurance by the NRC in its 1984 Waste Confidence Decision. This report describes general concepts related to the acceptability and unacceptability of the level of evidence needed to defend claims with reasonable assurance. The concepts were formulated on the basis of analyses of the NRC position papers, and of common aspects of the reviews and criticisms dealing with compliance demonstration

77 FR 50703 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-08-22

... . Name of Committee: Bioengineering Sciences & Technologies Integrated Review Group; Nanotechnology Study... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Dermatology and...

76 FR 2914 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-01-18

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict... Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Risk Prevention and Health... . Name of Committee: Immunology Integrated Review Group; Innate Immunity and Inflammation Study Section...

76 FR 5597 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-02-01

... Scientific Review Special Emphasis Panel; Small Business: Biomaterials, Delivery Systems, and Nanotechnology... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict...

Defining Baconian Probability for Use in Assurance Argumentation

Science.gov (United States)

Graydon, Patrick J.

2016-01-01

The use of assurance cases (e.g., safety cases) in certification raises questions about confidence in assurance argument claims. Some researchers propose to assess confidence in assurance cases using Baconian induction. That is, a writer or analyst (1) identifies defeaters that might rebut or undermine each proposition in the assurance argument and (2) determines whether each defeater can be dismissed or ignored and why. Some researchers also propose denoting confidence using the counts of defeaters identified and eliminated-which they call Baconian probability-and performing arithmetic on these measures. But Baconian probabilities were first defined as ordinal rankings which cannot be manipulated arithmetically. In this paper, we recount noteworthy definitions of Baconian induction, review proposals to assess confidence in assurance claims using Baconian probability, analyze how these comport with or diverge from the original definition, and make recommendations for future practice.

75 FR 8979 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-02-26

... Review Special Emphasis Panel, Biomaterials, Delivery Systems, and Nanotechnology. Date: March 15-16... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, PAR08-130...

The challenge of quality assurance

International Nuclear Information System (INIS)

Simon, R.; Krischer, W.; Price, M.S.T.

1986-01-01

The paper presents the aims of quality assurance in the design and production of radioactive waste packages. It lists the most relevant acceptance criteria and regulatory requirements, investigates the institutional and technical problems of carrying out Quality Assurance and presents suggestions for establishing suitable organisational structures and technical programmes to provide adequate confidence in the safe nature and the performance of waste packages. The Commission of European Communities has laid emphasis on the development of appropriate test methods in its last research and development programme. First results of the work are reviewed in the context of international progress in this field. (author)

75 FR 32958 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-06-10

...: Center for Scientific Review Special Emphasis Panel; Member Conflicts: Topics in Infectious Diseases and....gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Fellowships: Immunology...

77 FR 26771 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-05-07

[email protected] . Name of Committee: Center for Scientific Review Special Emphasis Panel; Motor... . Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Obesity...

42 CFR 440.260 - Methods and standards to assure quality of services.

Science.gov (United States)

2010-10-01

... 42 Public Health 4 2010-10-01 2010-10-01 false Methods and standards to assure quality of services. 440.260 Section 440.260 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH... and Limits Applicable to All Services § 440.260 Methods and standards to assure quality of services...

Independent oversight review of the Department of Energy Quality Assurance Program for suspect/counterfeit parts. Revision 1

International Nuclear Information System (INIS)

1996-05-01

To address the potential threat that suspect/counterfeit parts could pose to DOE workers and the public, the Office of the Deputy Assistant Secretary for Oversight initiated a number of activities beginning in mid-1995. Oversight placed increased emphasis on the field's quality assurance-suspect/counterfeit parts programs during safety management evaluations, in keeping with the Office of Environment, Safety and Health (EH) oversight responsibilities, which include oversight of the Department's quality assurance (QA) programs. In addition, Oversight reviewed relevant policy documents and occurrence reports to determine the nature and magnitude of the problem within the Department. The results of that review, contained in an Office of Oversight report, Independent Oversight Analysis of Suspect/Counterfeit Parts Within the Department of Energy (November 1995), indicate a lack of consistency and comprehensiveness in the Department's QA-suspect/counterfeit parts program. A detailed analysis of the causes and impacts of the problem was recommended. In response, this review was initiated to determine the effectiveness of the Department's QA program for suspect/counterfeit parts. This study goes beyond merely assessing and reporting the status of the program, however. It is the authors intention to highlight the complex issues associated with suspect/counterfeit parts in the Department today and to present approaches that DOE managers might consider to address these issues

Independent oversight review of the Department of Energy Quality Assurance Program for suspect/counterfeit parts. Revision 1

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-05-01

To address the potential threat that suspect/counterfeit parts could pose to DOE workers and the public, the Office of the Deputy Assistant Secretary for Oversight initiated a number of activities beginning in mid-1995. Oversight placed increased emphasis on the field`s quality assurance-suspect/counterfeit parts programs during safety management evaluations, in keeping with the Office of Environment, Safety and Health (EH) oversight responsibilities, which include oversight of the Department`s quality assurance (QA) programs. In addition, Oversight reviewed relevant policy documents and occurrence reports to determine the nature and magnitude of the problem within the Department. The results of that review, contained in an Office of Oversight report, Independent Oversight Analysis of Suspect/Counterfeit Parts Within the Department of Energy (November 1995), indicate a lack of consistency and comprehensiveness in the Department`s QA-suspect/counterfeit parts program. A detailed analysis of the causes and impacts of the problem was recommended. In response, this review was initiated to determine the effectiveness of the Department`s QA program for suspect/counterfeit parts. This study goes beyond merely assessing and reporting the status of the program, however. It is the authors intention to highlight the complex issues associated with suspect/counterfeit parts in the Department today and to present approaches that DOE managers might consider to address these issues.

75 FR 27793 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-05-18

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict... Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Mechanisms of Psychiatric... Integrated Review Group; Innate Immunity and Inflammation Study Section. Date: June 10-11, 2010. Time: 8 a.m...

76 FR 65739 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-10-24

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Review of the National Resource for Mass Spectrometry of Biological Macromolecules Date: November 13-15, 2011. Time: 8 a... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...

78 FR 52552 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-08-23

... & Technologies Integrated Review Group, Nanotechnology Study Section. Date: September 26-27, 2013. Time: 8:00 a.m... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Member Conflict...

77 FR 16845 - Center for Scientific Review; Notice of Closed Meeting

Science.gov (United States)

2012-03-22

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Center: Mass Spectrometry Resource for Biology and Medicine. Date: April 1-3, 2012. Time: 8 p.m. to 12 p.m. Agenda: To... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...

Quality Assurance Peer Review Chart Rounds in 2011: A Survey of Academic Institutions in the United States

International Nuclear Information System (INIS)

Lawrence, Yaacov Richard; Whiton, Michal A.; Symon, Zvi; Wuthrick, Evan J.; Doyle, Laura; Harrison, Amy S.; Dicker, Adam P.

2012-01-01

Purpose: In light of concerns regarding the quality of radiation treatment delivery, we surveyed the practice of quality assurance peer review chart rounds at American academic institutions. Methods and Materials: An anonymous web-based survey was sent to the chief resident of each institution across the United States. Results: The response rate was 80% (57/71). The median amount of time spent per patient was 2.7 minutes (range, 0.6–14.4). The mean attendance by senior physicians and residents was 73% and 93%, respectively. A physicist was consistently present at peer review rounds in 66% of departments. There was a close association between attendance by senior physicians and departmental organization: in departments with protected time policies, good attendance was 81% vs. 31% without protected time (p = 0.001), and in departments that documented attendance, attending presence was 69% vs. 29% in departments without documentation (p 75% of institutions, whereas dosimetric details (beams, wedges), isodose coverage, intensity-modulated radiation therapy constraints, and dose–volume histograms were always peer reviewed in 63%, 59%, 42%, and 50% of cases, respectively. Chart rounds led to both minor (defined as a small multileaf collimator change/repeated port film) and major (change to dose prescription or replan with dosimetry) treatment changes. Whereas at the majority of institutions changes were rare (<10% of cases), 39% and 11% of institutions reported that minor and major changes, respectively, were made to more than 10% of cases. Conclusion: The implementation of peer review chart rounds seems inconsistent across American academic institutions. Brachytherapy and radiosurgical procedures are rarely reviewed. Attendance by senior physicians is variable, but it improves when scheduling clashes are avoided. The potential effect of a more thorough quality assurance peer review on patient outcomes is not known.

77 FR 12605 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-03-01

..., (Virtual Meeting). Contact Person: Eduardo A Montalvo, Ph.D., Scientific Review Officer, Center for... Person: Allen Richon, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes...: Chemistry, Biochemistry, Biophysics, and Bioengineering. Date: March 15-20, 2012. Time: 11 a.m. to 5 p.m...

76 FR 31619 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-06-01

..., Delivery Systems, and Nanotechnology. Date: June 28, 2011. Time: 8 a.m. to 6 p.m. Agenda: To review and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Molecular...

78 FR 24224 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-04-24

... Integrated Review Group; Nanotechnology Study Section. Date: May 23-24, 2013. Time: 8:00 a.m. to 4:00 p.m... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel...

76 FR 9354 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-02-17

...: Center for Scientific Review Special Emphasis Panel; Member Conflict: Cancer Biology and Therapy. Date... (Telephone Conference Call). Contact Person: Fouad A. El-Zaatari, PhD, Scientific Review Officer, Center for...

77 FR 66623 - Center for Scientific Review; Notice of Closed Meetings

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2012-11-06

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76 FR 573 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-01-05

..., Nanotechnology Study Section. Date: February 3-4, 2011. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Member Conflicts...

77 FR 71604 - Center for Scientific Review; Notice of Closed Meeting

Science.gov (United States)

2012-12-03

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Topics in Nanotechnology and Tissue Engineering. Date: December 5, 2012. Time: 11:00 a.m. to 3:00 p.m. Agenda: To review... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...

Waste Management Quality Assurance Plan

International Nuclear Information System (INIS)

2006-01-01

The WMG QAP is an integral part of a management system designed to ensure that WMG activities are planned, performed, documented, and verified in a manner that assures a quality product. A quality product is one that meets all waste acceptance criteria, conforms to all permit and regulatory requirements, and is accepted at the offsite treatment, storage, and disposal facility. In addition to internal processes, this QA Plan identifies WMG processes providing oversight and assurance to line management that waste is managed according to all federal, state, and local requirements for waste generator areas. A variety of quality assurance activities are integral to managing waste. These QA functions have been identified in the relevant procedures and in subsequent sections of this plan. The WMG QAP defines the requirements of the WMG quality assurance program. These requirements are derived from Department of Energy (DOE) Order 414.1C, Quality Assurance, Contractor Requirements Document, the LBNL Operating and Assurance Program Plan (OAP), and other applicable environmental compliance documents. The QAP and all associated WMG policies and procedures are periodically reviewed and revised, as necessary, to implement corrective actions, and to reflect changes that have occurred in regulations, requirements, or practices as a result of feedback on work performed or lessons learned from other organizations. The provisions of this QAP and its implementing documents apply to quality-affecting activities performed by the WMG; WMG personnel, contractors, and vendors; and personnel from other associated LBNL organizations, except where such contractors, vendors, or organizations are governed by their own WMG-approved QA programs

75 FR 38111 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-07-01

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; PAR10-082: Mass Spectrometry Instrumentation. Date: July 19-20, 2010. Time: 8 a.m. to 6 p.m. Agenda: To review and evaluate... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...

78 FR 30318 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-05-22

... Computational Mass-Spectrometry. Date: June 19-21, 2013. Time: 7:00 p.m. to 1:00 p.m. Agenda: To review and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict...

78 FR 9931 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-02-12

... Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Abdelouahab Aitouche, Ph...). Contact Person: James J Li, Ph.D., Scientific Review Officer, Center for Scientific Review, National...: Chemistry, Biochemistry and Biophysics Date: March 6-7, 2013 Time: 8:30 a.m. to 5:00 p.m. Agenda: To review...

Development and oversight of ethical health promotion quality assurance and evaluation activities involving human participants.

Science.gov (United States)

Sainsbury, Peter

2015-12-01

This paper considers the role of ethics and ethics review processes in the development of health promotion quality assurance and evaluation activities involving human participants. The Australian National Health and Medical Research Council (NHMRC) National Statement on Ethical Conduct in Human Research and associated documents provide the framework for the ethical conduct and independent review of research (including quality assurance and evaluation) involving humans in Australia. Identifying the level of risk to which participants may be exposed by participation in quality assurance and evaluation activities is essential for health promotion workers undertaking such activities. Organisations can establish processes other than review by a Human Research Ethics Committee for negligible and low risk research activities. Health promotion quality assurance and evaluation activities often involve negligible and low risk to participants. Seven triggers that indicate the need for ethics review of quality assurance and evaluation activities and a procedural checklist for developing ethical quality assurance and evaluation activities are provided. Health promotion workers should be familiar with the NHMRC's National Statement on Ethical Conduct in Human Research. When ethical considerations underpin the planning and conduct of all quality assurance and evaluation from the very beginning, the activity is the better for it, independent 'ethics approval' can mostly be secured without much trouble and workers' frustration levels are reduced. So what? Health promotion quality assurance and evaluation activities must be ethically justified. Health promotion workers should be familiar with the NHMRC's National Statement on Ethical Conduct in Human Research and should use it when developing health promotion quality assurance and evaluation activities.

Quality Assurance Source Requirements Traceability Database

International Nuclear Information System (INIS)

MURTHY, R.; NAYDENOVA, A.; DEKLEVER, R.; BOONE, A.

2006-01-01

At the Yucca Mountain Project the Project Requirements Processing System assists in the management of relationships between regulatory and national/industry standards source criteria, and Quality Assurance Requirements and Description document (DOE/R W-0333P) requirements to create compliance matrices representing respective relationships. The matrices are submitted to the U.S. Nuclear Regulatory Commission to assist in the commission's review, interpretation, and concurrence with the Yucca Mountain Project QA program document. The tool is highly customized to meet the needs of the Office of Civilian Radioactive Waste Management Office of Quality Assurance

Evaluation of reliability assurance approaches to operational nuclear safety

International Nuclear Information System (INIS)

Mueller, C.J.; Bezella, W.A.

1984-01-01

This report discusses the results of research to evaluate existing and/or recommended safety/reliability assurance activities among nuclear and other high technology industries for potential nuclear industry implementation. Since the Three Mile Island (TMI) accident, there has been increased interest in the use of reliability programs (RP) to assure the performance of nuclear safety systems throughout the plant's lifetime. Recently, several Nuclear Regulatory Commission (NRC) task forces or safety issue review groups have recommended RPs for assuring the continuing safety of nuclear reactor plants. 18 references

Education for All in South Africa: Developing a National System for Quality Assurance.

Science.gov (United States)

Smith, William J.; Ngoma-Maema, Wendy Yolisa

2003-01-01

Draws on international research, policy, and practice relevant to quality assurance systems to analyze the development of a national framework for educational quality assurance in South Africa. Describes an emerging framework for quality assurance that encompasses evaluation of student achievement, quality audits and reviews, program and service…

Quality assurance in transnational higher education: a case study of the tropEd network.

Science.gov (United States)

Zwanikken, Prisca A C; Peterhans, Bernadette; Dardis, Lorraine; Scherpbier, Albert

2013-03-27

Transnational or cross-border higher education has rapidly expanded since the 1980s. Together with that expansion issues on quality assurance came to the forefront. This article aims to identify key issues regarding quality assurance of transnational higher education and discusses the quality assurance of the tropEd Network for International Health in Higher Education in relation to these key issues. Literature review and review of documents. From the literature the following key issues regarding transnational quality assurance were identified and explored: comparability of quality assurance frameworks, true collaboration versus erosion of national education sovereignty, accreditation agencies and transparency. The tropEd network developed a transnational quality assurance framework for the network. The network accredits modules through a rigorous process which has been accepted by major stakeholders. This process was a participatory learning process and at the same time the process worked positive for the relations between the institutions. The development of the quality assurance framework and the process provides a potential example for others.

Radiotherapy Quality Assurance Report From Children's Oncology Group AHOD0031

Energy Technology Data Exchange (ETDEWEB)

Dharmarajan, Kavita V. [Mount Sinai Medical Center, New York, New York (United States); Friedman, Debra L. [Vanderbilt University, Nashville, Tennessee (United States); FitzGerald, T.J. [Quality Assurance Review Center, Lincoln, Rhode Island (United States); McCarten, Kathleen M. [Rhode Island Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island (United States); Constine, Louis S. [University of Rochester Medical Center, Rochester, New York (United States); Chen, Lu [Children' s Oncology Group, Arcadia, California (United States); Kessel, Sandy K.; Iandoli, Matt; Laurie, Fran [Quality Assurance Review Center, Lincoln, Rhode Island (United States); Schwartz, Cindy L. [MD Anderson Cancer Center, Houston, Texas (United States); Wolden, Suzanne L., E-mail: woldens@mskcc.org [Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

2015-04-01

Purpose: A phase 3 trial assessing response-based therapy in intermediate-risk Hodgkin lymphoma mandated real-time central review of involved field radiation therapy (IFRT) and imaging records by a centralized review center to maximize protocol compliance. We report the impact of centralized radiation therapy review on protocol compliance. Methods and Materials: Review of simulation films, port films, and dosimetry records was required before and after treatment. Records were reviewed by study-affiliated or review center–affiliated radiation oncologists. A deviation of 6% to 10% from protocol-specified dose was scored as “minor”; a deviation of >10% was “major.” A volume deviation was scored as “minor” if margins were less than specified or “major” if fields transected disease-bearing areas. Interventional review and final compliance review scores were assigned to each radiation therapy case and compared. Results: Of 1712 patients enrolled, 1173 underwent IFRT at 256 institutions in 7 countries. An interventional review was performed in 88% of patients and a final review in 98%. Overall, minor and major deviations were found in 12% and 6% of patients, respectively. Among the cases for which ≥1 pre-IFRT modification was requested by the Quality Assurance Review Center and subsequently made by the treating institution, 100% were made compliant on final review. By contrast, among the cases for which ≥1 modification was requested but not made by the treating institution, 10% were deemed compliant on final review. Conclusions: In a large trial with complex treatment pathways and heterogeneous radiation therapy fields, central review was performed in a large percentage of cases before IFRT and identified frequent potential deviations in a timely manner. When suggested modifications were performed by the institutions, deviations were almost eliminated.

Radiotherapy Quality Assurance Report From Children's Oncology Group AHOD0031

International Nuclear Information System (INIS)

Dharmarajan, Kavita V.; Friedman, Debra L.; FitzGerald, T.J.; McCarten, Kathleen M.; Constine, Louis S.; Chen, Lu; Kessel, Sandy K.; Iandoli, Matt; Laurie, Fran; Schwartz, Cindy L.; Wolden, Suzanne L.

2015-01-01

Purpose: A phase 3 trial assessing response-based therapy in intermediate-risk Hodgkin lymphoma mandated real-time central review of involved field radiation therapy (IFRT) and imaging records by a centralized review center to maximize protocol compliance. We report the impact of centralized radiation therapy review on protocol compliance. Methods and Materials: Review of simulation films, port films, and dosimetry records was required before and after treatment. Records were reviewed by study-affiliated or review center–affiliated radiation oncologists. A deviation of 6% to 10% from protocol-specified dose was scored as “minor”; a deviation of >10% was “major.” A volume deviation was scored as “minor” if margins were less than specified or “major” if fields transected disease-bearing areas. Interventional review and final compliance review scores were assigned to each radiation therapy case and compared. Results: Of 1712 patients enrolled, 1173 underwent IFRT at 256 institutions in 7 countries. An interventional review was performed in 88% of patients and a final review in 98%. Overall, minor and major deviations were found in 12% and 6% of patients, respectively. Among the cases for which ≥1 pre-IFRT modification was requested by the Quality Assurance Review Center and subsequently made by the treating institution, 100% were made compliant on final review. By contrast, among the cases for which ≥1 modification was requested but not made by the treating institution, 10% were deemed compliant on final review. Conclusions: In a large trial with complex treatment pathways and heterogeneous radiation therapy fields, central review was performed in a large percentage of cases before IFRT and identified frequent potential deviations in a timely manner. When suggested modifications were performed by the institutions, deviations were almost eliminated

Role of Informatics in Patient Safety and Quality Assurance.

Science.gov (United States)

Nakhleh, Raouf E

2015-06-01

Quality assurance encompasses monitoring daily processes for accurate, timely, and complete reports in surgical pathology. Quality assurance also includes implementation of policies and procedures that prevent or detect errors in a timely manner. This article presents uses of informatics in quality assurance. Three main foci are critical to the general improvement of diagnostic surgical pathology. First is the application of informatics to specimen identification with lean methods for real-time statistical control of specimen receipt and processing. Second is the development of case reviews before sign-out. Third is the development of information technology in communication of results to assure treatment in a timely manner. Copyright © 2015 Elsevier Inc. All rights reserved.

The role of quality assurance in the nuclear industry

International Nuclear Information System (INIS)

1985-01-01

The paper reports on the proceedings of a one day conference on ''the role of quality assurance in the nuclear industry'', presented by the British Nuclear Forum Working Group on Quality Assurance, 1985. The conference reviews the application and effectiveness of the British Standards in the light of experience with the AGR programme, and considers the lessons learned that will benefit future projects. Seven papers are presented at the conference, of which five deal with the AGR experience with respect to quality assurance in design and manufacture. The remaining two papers examine quality assurance in computing software and building on the AGR experience. All seven papers are selected for INIS and indexed separately. (U.K.)

Development of a quality-assurance program for the Tritium Systems Test Assembly

International Nuclear Information System (INIS)

Minor, R.C.

1981-01-01

A quality assurance program was developed for TSTA with the attempt in mind to satisfy the developmental nature of the project. Numerous reviews replace strict guidelines because guidelines are one of the objectives of the project, not a basis for it. The reviews assure adequate technical consideration and avoid unilateral decisions. Other major requirements of the program plan include interfacing with another quality assurance organization, the assignment of responsibilities, and instructions for the preparation of SDD's. Areas of concern are, in general, budget related, and include receiving inspection and acceptance of items. A software program is only now being established

Gynecologic Oncology Group quality assurance audits: analysis and initiatives for improvement.

Science.gov (United States)

Blessing, John A; Bialy, Sally A; Whitney, Charles W; Stonebraker, Bette L; Stehman, Frederick B

2010-08-01

The Gynecologic Oncology Group (GOG) is a multi-institution, multi-discipline Cooperative Group funded by the National Cancer Institute (NCI) to conduct clinical trials which investigate the treatment, prevention, control, quality of survivorship, and translational science of gynecologic malignancies. In 1982, the NCI initiated a program of on-site quality assurance audits of participating institutions. Each is required to be audited at least once every 3 years. In GOG, the audit mandate is the responsibility of the GOG Quality Assurance Audit Committee and it is centralized in the Statistical and Data Center (SDC). Each component (Regulatory, Investigational Drug Pharmacy, Patient Case Review) is classified as Acceptable, Acceptable, follow-up required, or Unacceptable. To determine frequently occurring deviations and develop focused innovative solutions to address them. A database was created to examine the deviations noted at the most recent audit conducted at 57 GOG parent institutions during 2004-2007. Cumulatively, this involved 687 patients and 306 protocols. The results documented commendable performance: Regulatory (39 Acceptable, 17 Acceptable, follow-up, 1 Unacceptable); Pharmacy (41 Acceptable, 3 Acceptable, follow-up, 1 Unacceptable, 12 N/A): Patient Case Review (31 Acceptable, 22 Acceptable, follow-up, 4 Unacceptable). The nature of major and lesser deviations was analyzed to create and enhance initiatives for improvement of the quality of clinical research. As a result, Group-wide proactive initiatives were undertaken, audit training sessions have emphasized recurring issues, and GOG Data Management Subcommittee agendas have provided targeted instruction and training. The analysis was based upon parent institutions only; affiliate institutions and Community Clinical Oncology Program participants were not included, although it is assumed their areas of difficulty are similar. The coordination of the GOG Quality Assurance Audit program in the SDC has

75 FR 22819 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-04-30

[email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific Review Special... 20892, 301-435- 0903, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special...

Quality assurance program preparation - review of requirements and plant systems - selection of program levels

International Nuclear Information System (INIS)

Asmuss, G.

1980-01-01

The establishment and implementation for a practicable quality assurance program for a nuclear power plant demands a detailed background in the field of engineering, manufacturing, organization and quality assurance. It will be demonstrated with examples to define and control the achievement of quality related activities during the phases of design, procurement, manufactoring, commissioning and operation. In general the quality assurance program applies to all items, processes and services important to safety of nuclear power plant. The classification for safety related and non-safety related items and services demonstrate the levels of quality assurance requirements. The lecture gives an introduction of QA Program preparation under the following topics: -Basic criteria and international requirements - Interaction of QA activities - Modular and product oriented QA programs - Structuring of organization for the QA program - Identification of the main quality assurance functions and required actions - Quality Assurance Program documentation - Documentation of planning of activities - Control of program documents - Definitions. (orig./RW)

An Artist in the University Medical Center. Review.

Science.gov (United States)

James, A. Everette, Jr.

1991-01-01

Reviews "An Artist in the University Medical Center" (M. Lesser, New Orleans: Tulane University Press, 1989), in which the artist captures the human side of the complex Tulane Medical Center in New Orleans (Louisiana). The interplay of drawings, etchings, watercolors, and prose conveys traditions of nurturing in the hospital. (SLD)

Quality Assurance of Quality Assurance Agencies from an Asian Perspective: Regulation, Autonomy and Accountability

Science.gov (United States)

Hou, Angela Yung-Chi; Ince, Martin; Tsai, Sandy; Chiang, Chung Lin

2015-01-01

As quality guardians of higher education, quality assurance agencies are required to guarantee the credibility of the review process and to ensure the objectivity and transparency of their decisions and recommendations. These agencies are therefore expected to use a range of internal and external approaches to prove the quality of their review…

Assuring Software Reliability

Science.gov (United States)

2014-08-01

technologies and processes to achieve a required level of confidence that software systems and services function in the intended manner. 1.3 Security Example...that took three high-voltage lines out of service and a software fail- ure (a race condition3) that disabled the computing service that notified the... service had failed. Instead of analyzing the details of the alarm server failure, the reviewers asked why the following software assurance claim had

Introducing quality assurance and medical audit into the UCSF medical center curriculum.

Science.gov (United States)

Barbaccia, J C

1976-05-01

The experience gained by a medical school faculty in developing and piloting a course for undergraduate medical students in medical care evaluation led to a similar effort for house staff. It is recognized that if the profession is to fulfill the demand by society for social accountability in the use of resources for health care, medical care assessment and quality assurance mechanisms must become an intimate part of the clinical experience of medical students and house officers. Teaching these subjects requires a theoretical framework; introduction of content and skills appropriate to the level of the student and continuation of progressively more advanced training throughout medical education; use of assessment and quality assurance techniques by clinician-teachers themselves to provide models for the student; and continued evolution of pedagogic approach and course content based on developments in the area.

Improving the Quality of Services in Residential Treatment Facilities: A Strength-Based Consultative Review Process

Science.gov (United States)

Pavkov, Thomas W.; Lourie, Ira S.; Hug, Richard W.; Negash, Sesen

2010-01-01

This descriptive case study reports on the positive impact of a consultative review methodology used to conduct quality assurance reviews as part of the Residential Treatment Center Evaluation Project. The study details improvement in the quality of services provided to youth in unmonitored residential treatment facilities. Improvements were…

Quality assurance measures in interventional radiology

International Nuclear Information System (INIS)

Heuser, L.

1999-01-01

The quality assurance of treatment measures is legally required but as yet not generally established in practice. For interventional radiology, the introduction of quality assurance for PTA of arteries of the lower limbs is planned for January 1999. It is reasonable to subject at least the most important and/or most frequently performed interventions to quality management. In the present article, the term quality in the management of diseases is defined and the system of total quality management discussed at the levels structure, process, and results. For its application, parameters of quality measurement in the form of standards, criteria, and characteristic values are necessary and must be laid down by a team of experts on the basis of subjective experience and/or results in the literature. Practical quality assurance takes place not only within a clinic but also externally by comparison with other centers. Data collection and evaluation requires high-performance software that will be continuously improved, expanded, and adapted to current needs during regular meetings between the various users. (orig.) [de

The quality assurance liaison: Combined technical and quality assurance support

International Nuclear Information System (INIS)

Bolivar, S.L.; Day, J.L.

1993-01-01

This paper describes the role of the quality assurance liaison, the responsibilities of this position, and the evolutionary changes in duties over the last six years. The role of the quality assurance liaison has had a very positive impact on the Los Alamos Yucca Mountain Site Characterization (YW) quality assurance program. Having both technical and quality assurance expertise, the quality assurance liaisons are able to facilitate communications with scientists on quality assurance issues and requirements, thereby generating greater productivity in scientific investigations. The quality assurance liaisons help ensure that the scientific community knows and implements existing requirements, is aware of new or changing regulations, and is able to conduct scientific work within Project requirements. The influence of the role of the quality assurance liaison can be measured by an overall improvement in attitude of the staff regarding quality assurance requirements and improved job performance, as well as a decrease in deficiencies identified during both internal and external audits and surveillances. This has resulted in a more effective implementation of quality assurance requirements

Organizing safety: conditions for successful information assurance programs.

Science.gov (United States)

Collmann, Jeff; Coleman, Johnathan; Sostrom, Kristen; Wright, Willie

2004-01-01

Organizations must continuously seek safety. When considering computerized health information systems, "safety" includes protecting the integrity, confidentiality, and availability of information assets such as patient information, key components of the technical information system, and critical personnel. "High Reliability Theory" (HRT) argues that organizations with strong leadership support, continuous training, redundant safety mechanisms, and "cultures of high reliability" can deploy and safely manage complex, risky technologies such as nuclear weapons systems or computerized health information systems. In preparation for the Health Insurance Portability and Accountability Act (HIPAA) of 1996, the Office of the Assistant Secretary of Defense (Health Affairs), the Offices of the Surgeons General of the United States Army, Navy and Air Force, and the Telemedicine and Advanced Technology Research Center (TATRC), US Army Medical Research and Materiel Command sponsored organizational, doctrinal, and technical projects that individually and collectively promote conditions for a "culture of information assurance." These efforts include sponsoring the "P3 Working Group" (P3WG), an interdisciplinary, tri-service taskforce that reviewed all relevant Department of Defense (DoD), Miliary Health System (MHS), Army, Navy and Air Force policies for compliance with the HIPAA medical privacy and data security regulations; supporting development, training, and deployment of OCTAVE(sm), a self-directed information security risk assessment process; and sponsoring development of the Risk Information Management Resource (RIMR), a Web-enabled enterprise portal about health information assurance.

76 FR 22716 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-04-22

..., Bethesda, MD 20892, 301-402- 5671, [email protected] . Name of Committee: Brain Disorders and Clinical... Disorders and Clinical Neuroscience, Center for Scientific Review, National Institutes of Health, 6701... Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Kidney, Urology Continues...

77 FR 65570 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-10-29

... Conference Call). Contact Person: Carol Hamelink, Ph.D., Scientific Review Officer, Center for Scientific...--Convention Center, 900 10th Street NW., Washington, DC 20001. Contact Person: Mark P Rubert, Ph.D... for Scientific Review Special Emphasis Panel; Fellowships: Chemistry, Biochemistry and Biophysics...

Chapter 8: Quality assurance

International Nuclear Information System (INIS)

2001-01-01

The main efforts of Nuclear Regulatory Authority of the Slovak Republic (UJD) have been focused on inspection of quality assurance programmes of Slovak Power Stations, plc. and its daughter companies at Bohunice and Mochovce. Two quality assurance inspections in the area of periodical in service inspections (V-2 units) and tests of selected equipment (NPP V-2 units) and operation control (V-1 units) has been performed at NPPs Bohunice. One violation of decree on quality assurance of selected equipment has been found in the area of documentation archiving. The inspection concerning the implementation of quality assurance programme for operation of NPP Mochovce in the area of operation control has been performed focused on safety aspects of operation, operational procedures, control of operational events and feedback from operational experience. The results of this inspection were positive. Inspection of implementation of quality assurance programme for operation of radioactive waste repository (RU RAW) at the Mochovce location has been performed focused on receiving of containers, with radioactive wastes, containers handling, radiation monitoring, activities of documentation control and radiation protection at the repository site. No serious deficiencies have been found out. Also one inspection of experimental nuclear installations of VUJE Trnava at Jaslovske Bohunice site has been performed focused on procurement control, quality audits, documentation and quality records control when performing activities at experimental nuclear installations. The activity on development of internal quality assurance system continued. The implementation of this system will assure quality and effective fulfilment enlarged tasks of UJD with limited resources for its activity. The analyses of possible use of existing internal administrative control documentation as a basis for future quality system procedures was performed in co-operation with an external specialised organisation. The

Quality assurance in the design

International Nuclear Information System (INIS)

Edelmann, J.

1980-01-01

System- and product-related quality assurance measures are completing one another. Certainly it is possible to detect a lot of defects in the single technical document by well controlled product related quality inspections and to avoid the consequences of these defects; but also a not unimportant part of defects and deviations has its origin in system linked deficiencies. The latter can be detected more easily and more securely by means of system related reviews (System audit, Product audit). But also the sole implementation of system related quality assurance measures keeps the danger to get stuck only in formality and to loose all references to the specific characteristics of the product. (orig./RW)

Exploration of reliability assurance program (RAP) for advanced nuclear power plant

International Nuclear Information System (INIS)

Chen Fang; Xu Rongbin

2009-01-01

This article describes the new requirements in US SRP on Reliability Assurance Program, inquires into the evolution of the reliability assurance requirements, and investigates the regulatory requirements on reliability assurance program for advanced reactors, it's main contents, and evaluation review practices and related issues, with the aim of enabling staff to understand be familiar and pay attention to this engineering program. This article may be as a reference for related workers. (authors)

Methods of Software Quality Assurance under a Nuclear Quality Assurance Program

International Nuclear Information System (INIS)

Kim, Jang Yeol; Lee, Young Jun; Cha, Kyung Ho; Cheon, Se Woo; Lee, Jang Soo; Kwon, Kee Choon

2005-01-01

This paper addresses a substantial implementation of a software quality assurance under a nuclear quality assurance program. The relationship of the responsibility between a top-level nuclear quality assurance program such as ASME/NQA-1 and its lower level software quality assurance is described. Software quality assurance activities and software quality assurance procedures during the software development life cycle are also described

Energy Assurance Technical Training and Awareness Program/Energy Infrastructure Training and Analysis Center

Energy Technology Data Exchange (ETDEWEB)

Barbara McCabe

2005-11-15

This report covers the work completed during Year One (Year One has a 16 month project period) of a five- year Cooperative Agreement (DE-FC26-03NT41895) between the International Union of Operating Engineers (IUOE) National Hazmat Program (OENHP) and the U. S. Department of Energy (DOE) National Energy Technology Laboratory (NETL). This final technical report is being submitted, as required by the Cooperative Agreement, within 90 (calendar) days after the project period ends (December 31, 2004). The resources allocated to Year One of the Cooperative Agreement were adequate for the completion of the required deliverables. All deliverables have been completed and sent to AAD Document Control as directed in the cooperative agreement. The allocation for Year One required 20-25 trainers to be trained in each of five Train-the-Trainer courses and a total of 6,000 workers trained throughout the country. Through cost savings employed for the scheduling and conduct of Train-the-Trainer, instructor refreshers, and direct training classes, 3171 workers have been trained to date. This total incorporates 159 trainers and members from management, local, county, state and federal organizations identified in the Strategic Plan. The largest percentage of personnel trained is heavy equipment operators, and building engineers, which is the largest targeted population identified under this cooperative agreement. The OENHP, using existing curriculum as appropriate, has modified and developed new training modules that have been used to establish four different levels of training courses. The four courses are: (1) EA 500 Energy Assurance Train-the-Trainer, (2) EA 400 Energy Assurance Instructor Refresher, (3) EA 300 Energy Assurance, and (4) EA 100 Energy Assurance Awareness. Training modules cover topics, such as, but not limited to, facility vulnerability and vulnerability assessment, physical security- heating, ventilation, air conditioning, terrorism awareness, weapons of mass

77 FR 48527 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-08-14

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; PAR012-017: Shared Mass Spectrometry Instrumentation. Date: September 6-7, 2012. Time: 8:30 a.m. to 12 p.m. Agenda... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...

Waste Management Quality Assurance Plan

International Nuclear Information System (INIS)

1993-01-01

Lawrence Berkeley Laboratory's Environment Department addresses its responsibilities through activities in a variety of areas. The need for a comprehensive management control system for these activities has been identified by the Department of Energy (DOE). The WM QA (Waste Management Quality Assurance) Plan is an integral part of a management system that provides controls necessary to ensure that the department's activities are planned, performed, documented, and verified. This WM QA Plan defines the requirements of the WM QA program. These requirements are derived from DOE Order 5700.6C, Quality Assurance, the LBL Operating and Assurance Program Plan (OAP, LBL PUB-3111), and other environmental compliance documents applicable to WM activities. The requirements presented herein, as well as the procedures and methodologies that direct the implementation of these requirements, will undergo review and revisions as necessary. The provisions of this QA Plan and its implementing documents apply to quality-affecting activities performed by and for WM. It is also applicable to WM contractors, vendors, and other LBL organizations associated with WM activities, except where such contractors, vendors, or organizations are governed by their own WM-approved QA programs. References used in the preparation of this document are (1) ASME NQA-1-1989, (2) ANSI/ASQC E4 (Draft), (3) Waste Management Quality Assurance Implementing Management Plan (LBL PUB-5352, Rev. 1), (4) LBL Operating and Assurance Program Plan (OAP), LBL PUB-3111, 2/3/93. A list of terms and definitions used throughout this document is included as Appendix A

76 FR 5182 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-01-28

...: Center for Scientific Review Special Emphasis Panel, PAR-10-235: Climate Change and Health. Date: March 1... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...: Cancer Health Disparities and Diversity in Basic Cancer Research. Date: March 1, 2011. Time: 8 a.m. to 5...

76 FR 44942 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-07-27

...: Sensation and Perception. Date: August 17-18, 2011. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate... (Virtual Meeting). Contact Person: John Bishop, PhD, Scientific Review Officer, Center for Scientific..., MD 20892 (Telephone Conference Call) Contact Person: Samuel C. Edwards, PhD, Chief, Center for...

76 FR 29770 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-05-23

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C...: Center for Scientific Review Special Emphasis Panel; Program Project: Regulation of Mammalian Meiosis...

Software for Optimizing Quality Assurance of Other Software

Science.gov (United States)

Feather, Martin; Cornford, Steven; Menzies, Tim

2004-01-01

Software assurance is the planned and systematic set of activities that ensures that software processes and products conform to requirements, standards, and procedures. Examples of such activities are the following: code inspections, unit tests, design reviews, performance analyses, construction of traceability matrices, etc. In practice, software development projects have only limited resources (e.g., schedule, budget, and availability of personnel) to cover the entire development effort, of which assurance is but a part. Projects must therefore select judiciously from among the possible assurance activities. At its heart, this can be viewed as an optimization problem; namely, to determine the allocation of limited resources (time, money, and personnel) to minimize risk or, alternatively, to minimize the resources needed to reduce risk to an acceptable level. The end result of the work reported here is a means to optimize quality-assurance processes used in developing software.

Dosimetric commissioning and quality assurance of scanned ion beams at the Italian National Center for Oncological Hadrontherapy

Energy Technology Data Exchange (ETDEWEB)

Mirandola, Alfredo, E-mail: mirandola@cnao.it; Molinelli, S.; Vilches Freixas, G.; Mairani, A.; Gallio, E.; Panizza, D.; Russo, S.; Ciocca, M. [Fondazione CNAO, strada Campeggi 53, Pavia 27100 (Italy); Donetti, M. [INFN, Torino 10125, Italy and Fondazione CNAO, strada Campeggi 53, Pavia 27100 (Italy); Magro, G. [INFN–Dipartimento di Fisica, Università degli Studi di Pavia, Via U. Bassi 6, Pavia 27100, Italy and Fondazione CNAO, strada Campeggi 53, Pavia 27100 (Italy); Giordanengo, S. [INFN, Torino 10125 (Italy); Orecchia, R. [Fondazione CNAO, strada Campeggi 53, Pavia 27100, Italy and Radiotherapy Division, European Institute of Oncology, Via Ripamonti 435, Milano 20141 (Italy)

2015-09-15

Purpose: To describe the dosimetric commissioning and quality assurance (QA) of the actively scanned proton and carbon ion beams at the Italian National Center for Oncological Hadrontherapy. Methods: The laterally integrated depth-dose-distributions (IDDs) were acquired with the PTW Peakfinder, a variable depth water column, equipped with two Bragg peak ionization chambers. FLUKA Monte Carlo code was used to generate the energy libraries, the IDDs in water, and the fragment spectra for carbon beams. EBT3 films were used for spot size measurements, beam position over the scan field, and homogeneity in 2D-fields. Beam monitor calibration was performed in terms of number of particles per monitor unit using both a Farmer-type and an Advanced Markus ionization chamber. The beam position at the isocenter, beam monitor calibration curve, dose constancy in the center of the spread-out-Bragg-peak, dose homogeneity in 2D-fields, beam energy, spot size, and spot position over the scan field are all checked on a daily basis for both protons and carbon ions and on all beam lines. Results: The simulated IDDs showed an excellent agreement with the measured experimental curves. The measured full width at half maximum (FWHM) of the pencil beam in air at the isocenter was energy-dependent for both particle species: in particular, for protons, the spot size ranged from 0.7 to 2.2 cm. For carbon ions, two sets of spot size are available: FWHM ranged from 0.4 to 0.8 cm (for the smaller spot size) and from 0.8 to 1.1 cm (for the larger one). The spot position was accurate to within ±1 mm over the whole 20 × 20 cm{sup 2} scan field; homogeneity in a uniform squared field was within ±5% for both particle types at any energy. QA results exceeding tolerance levels were rarely found. In the reporting period, the machine downtime was around 6%, of which 4.5% was due to planned maintenance shutdowns. Conclusions: After successful dosimetric beam commissioning, quality assurance measurements

Dosimetric commissioning and quality assurance of scanned ion beams at the Italian National Center for Oncological Hadrontherapy

International Nuclear Information System (INIS)

Mirandola, Alfredo; Molinelli, S.; Vilches Freixas, G.; Mairani, A.; Gallio, E.; Panizza, D.; Russo, S.; Ciocca, M.; Donetti, M.; Magro, G.; Giordanengo, S.; Orecchia, R.

2015-01-01

Purpose: To describe the dosimetric commissioning and quality assurance (QA) of the actively scanned proton and carbon ion beams at the Italian National Center for Oncological Hadrontherapy. Methods: The laterally integrated depth-dose-distributions (IDDs) were acquired with the PTW Peakfinder, a variable depth water column, equipped with two Bragg peak ionization chambers. FLUKA Monte Carlo code was used to generate the energy libraries, the IDDs in water, and the fragment spectra for carbon beams. EBT3 films were used for spot size measurements, beam position over the scan field, and homogeneity in 2D-fields. Beam monitor calibration was performed in terms of number of particles per monitor unit using both a Farmer-type and an Advanced Markus ionization chamber. The beam position at the isocenter, beam monitor calibration curve, dose constancy in the center of the spread-out-Bragg-peak, dose homogeneity in 2D-fields, beam energy, spot size, and spot position over the scan field are all checked on a daily basis for both protons and carbon ions and on all beam lines. Results: The simulated IDDs showed an excellent agreement with the measured experimental curves. The measured full width at half maximum (FWHM) of the pencil beam in air at the isocenter was energy-dependent for both particle species: in particular, for protons, the spot size ranged from 0.7 to 2.2 cm. For carbon ions, two sets of spot size are available: FWHM ranged from 0.4 to 0.8 cm (for the smaller spot size) and from 0.8 to 1.1 cm (for the larger one). The spot position was accurate to within ±1 mm over the whole 20 × 20 cm"2 scan field; homogeneity in a uniform squared field was within ±5% for both particle types at any energy. QA results exceeding tolerance levels were rarely found. In the reporting period, the machine downtime was around 6%, of which 4.5% was due to planned maintenance shutdowns. Conclusions: After successful dosimetric beam commissioning, quality assurance measurements

The Evolution of the NASA Commercial Crew Program Mission Assurance Process

Science.gov (United States)

Canfield, Amy C.

2016-01-01

In 2010, the National Aeronautics and Space Administration (NASA) established the Commercial Crew Program (CCP) in order to provide human access to the International Space Station and low Earth orbit via the commercial (non-governmental) sector. A particular challenge to NASA has been how to determine that the Commercial Provider's transportation system complies with programmatic safety requirements. The process used in this determination is the Safety Technical Review Board which reviews and approves provider submitted hazard reports. One significant product of the review is a set of hazard control verifications. In past NASA programs, 100% of these safety critical verifications were typically confirmed by NASA. The traditional Safety and Mission Assurance (S&MA) model does not support the nature of the CCP. To that end, NASA S&MA is implementing a Risk Based Assurance process to determine which hazard control verifications require NASA authentication. Additionally, a Shared Assurance Model is also being developed to efficiently use the available resources to execute the verifications.

Application of quality assurance to MC and A systems

International Nuclear Information System (INIS)

Skinner, A.J.; Delvin, W.L.

1986-01-01

Application of the principles of quality assurance to MC and A has been done at DOE's Savannah River Operations Office. The principles were applied to the functions within the MC and A Branch, including both the functions used to operate the Branch and those used to review the MC and A activities of DOE/SR's contractor. The purpose of this paper is to discuss that application of quality assurance and to show how the principles of quality assurance relate to the functions of a MC and A system, for both a DOE field office and a contractor. The principles (presented as requirements from the NQA-1 standard) are briefly discussed, a method for applying quality assurance is outlined, application at DOE/SR is shown, and application to a contractor's MC and A system is discussed

Johnson Space Center Health and Medical Technical Authority

Science.gov (United States)

Fogarty, Jennifer A.

2010-01-01

1.HMTA responsibilities: a) Assure program/project compliance with Agency health and medical requirements at identified key decision points. b) Certify that programs/projects comply with Agency health and medical requirements prior to spaceflight missions. c) Assure technical excellence. 2. Designation of applicable NASA Centers for HMTA implementation and Chief Medical Officer (CMO) appointment. 3. Center CMO responsible for HMTA implementation for programs and projects at the center. JSC HMTA captured in "JSC HMTA Implementation Plan". 4. Establishes specifics of dissenting opinion process consistent with NASA procedural requirements.

Quality assurance in education: The role of ICT and quality control ...

African Journals Online (AJOL)

Quality assurance in education is perceived in this paper to be a product of the impact of information and communication technologies as well as the statutory control measures especially in tertiary institutions in Nigeria. The paper reviews the concept of quality and quality assurance and their general application to ...

78 FR 40487 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-07-05

... Committee: Center for Scientific Review Special Emphasis Panel; Biomedical Technology Research Center: A Biomedical- Informatics Research Network for Big Data. Date: July 30-August 1, 2013. Time: 6:00 p.m. to 1:00... Scientific Review Special Emphasis Panel; Gene Therapy Member Conflicts. Date: July 30, 2013. Time: 3:00 p.m...

78 FR 14099 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-03-04

..., (301) 435-1165, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Biopsychosocial Issues in Patient Management. Date: March 22, 2013. Time: 3:00 p..., Bethesda, MD 20892, 301-435-2365, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review...

Supply assurance in the nuclear fuel cycle

International Nuclear Information System (INIS)

Neff, T.L.; Jacoby, H.D.

1979-01-01

Nuclear fuel assurance, in the face of world and political uncertainties, is interrelated with nuclear technology development plans and international safeguards considerations. This has led some countries to accelerate their commitments to nuclear commercialization faster than necessary and has made non-proliferation policies harder to enforce. Fuel assurance is described on a national basis in three time scales: short-term, or resilience to supply interruptions; mid-term, or contract conditions in which governments make commitments to purchase or deliver; and long-term, or resource adequacy. A review of former assurance problems and current trends in the enrichment and uranium markets indicates that supplier concentration is no longer the major problem so much as non-proliferation actions. The present state of unstable equilibrium is expected to move in the direction of less fuel-supply assurance for countries having a small market or not subscribing to non-proliferation criteria. The authors, while generally optimistic that the fuel-supply system will function, express concern that policies for fuel stockpiles and the condition of uranium markets need improvement. 21 references

Hyperthermia quality assurance

International Nuclear Information System (INIS)

Shrivastava, P.N.; Paliwal, B.R.

1984-01-01

Hyperthermia Physics Center (HPC) operating under contract with the National Cancer Institute is developing a Quality Assurance program for local and regional hyperthermia. The major clinical problem in hyperthermia treatments is that they are extremely difficult to plan, execute, monitor and reproduce. A scientific basis for treatment planning can be established only after ensuring that the performance of heat generating and temperature monitoring systems are reliable. The HPC is presently concentrating on providing uniform NBS traceable calibration of thermometers and evaluation of reproducibility for power generator operation, applicator performance, phanta compositions, system calibrations and personnel shielding. The organizational plan together with recommended evaluation measurements, procedures and criteria are presented

78 FR 61376 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-10-03

...-1215, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for...-435-1137, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis...

Quality Assurance Program: Argonne peer review activities for the salt host-rock portion of the Civilian Radioactive Waste Management Program

International Nuclear Information System (INIS)

Edgar, D.E.

1986-01-01

This Quality Assurance (QA) Program sets forth the methods, controls, and procedures used to ensure that the results of Argonne National Laboratory's peer review activities are consistently of the highest quality and responsive to Salt Repository Project Office's needs and directives. Implementation of the QA procedures described herein establishes an operational framework so that task activities are traceable and the activities and decisions that influence the overall quality of the peer review process and results are fully documented. 56 refs., 5 figs., 6 tabs

Quality Assurance: Strategic Choices for Higher Education in Turkey

Directory of Open Access Journals (Sweden)

Mahmut ÖZER

2011-01-01

Full Text Available As the number of students and higher education institutions in the world increases and there is a growing difficulty in financing the higher education systems, decision-makers have begun to show more interest in quality assurance. As quality assurance is given special attention in European countries, developing countries such as Turkey are interested in importing quality assurance systems. It is not possible to set quality assurance without sensitivity toward quality and without having quality as a cultural practice. The most likely encountered quality assurance approach in the world is that the higher education institution itself is responsible for its quality. In addition, external quality assurance procedures used are based on (academic peer review rather than on bureaucratic evaluations. Moreover, there is a lively debate across the world regarding the bureaucratic regulations of the quality assurance agencies and institutions that restrict the autonomy of higher education institutions. Without taking into consideration of the existing centralized structure of the higher education system in Turkey, of meeting social demands for the higher education, and of current higher education enrollment rates, the possible establishment of a quality assurance mechanism that may have sanctions on universities in Turkey is a threat to already limited autonomy of universities and is having a risk of additional bureaucratic burden. By laying out the roles and responsibilities of Turkish Council of Higher Education, the government and universities, this article discusses policies that should be adopted regarding the quality assurance.

75 FR 1066 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-01-08

... Person: Patrick K. Lai, PhD, Scientific Review Officer, Center for Scientific Review, National Institutes... Committee: Brain Disorders and Clinical Neuroscience Integrated Review Group; Clinical Neuroscience and...

77 FR 293 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-01-04

.... Contact Person: Patrick K Lai, Ph.D., Scientific Review Officer, Center for Scientific Review, [email protected] . Name of Committee: Brain Disorders and Clinical Neuroscience Integrated Review Group...

77 FR 60446 - Center for Scientific Review; Notice of Closed Meeting

Science.gov (United States)

2012-10-03

... Panel; Genomic, Molecular Genetics Variation Studies Using Model Organisms AREA Review. Date: October 19...: David J Remondini, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes...

78 FR 7438 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-02-01

... Rockledge Drive, Bethesda, MD 20892. Contact Person: Melinda Jenkins, Ph.D., Scientific Review Officer... Henry, Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health...

76 FR 12980 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-03-09

[email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific Review Special..., Bethesda, MD 20892, 301-435-1022, [email protected]csr.nih.gov . Name of Committee: Center for Scientific...

Application of quality assurance to scientific activities at Westinghouse Hanford Company

International Nuclear Information System (INIS)

Delvin, W.L.; Farwick, D.G.

1988-01-01

The application of quality assurance to scientific activities has been an ongoing subject of review, discussion, interpretation, and evaluation within the nuclear community for the past several years. This paper provides a discussion on the natures of science and quality assurance and presents suggestions for integrating the two successfully. The paper shows how those actions were used at the Westinghouse Hanford Company to successfully apply quality assurance to experimental studies and materials testing and evaluation activities that supported a major project. An important factor in developing and implementing the quality assurance program was the close working relationship that existed between the assigned quality engineers and the scientists. The quality engineers, who had had working experience in the scientific disciplines involved, were able to bridge across from the scientists to the more traditional quality assurance personnel who had overall responsibility for the project's quality assurance program

Quality Assurance - Construction

DEFF Research Database (Denmark)

Gaarslev, Axel

1996-01-01

Gives contains three main chapters:1. Quality Assurance initiated by external demands2. Quality Assurance initiated by internal company goals3. Innovation strategies......Gives contains three main chapters:1. Quality Assurance initiated by external demands2. Quality Assurance initiated by internal company goals3. Innovation strategies...

Results of a Quality Assurance Review of External Beam Radiation Therapy in the International Society of Paediatric Oncology (Europe) Neuroblastoma Group's High-risk Neuroblastoma Trial: A SIOPEN Study

International Nuclear Information System (INIS)

Gaze, Mark N.; Boterberg, Tom; Dieckmann, Karin; Hörmann, Marcus; Gains, Jennifer E.; Sullivan, Kevin P.; Ladenstein, Ruth

2013-01-01

Purpose: Radiation therapy is important for local control in neuroblastoma. This study reviewed the compliance of plans with the radiation therapy guidelines of the International Society of Paediatric Oncology (Europe) Neuroblastoma Group (SIOPEN) High-Risk Trial protocol. Methods and Materials: The SIOPEN trial central electronic database has sections to record diagnostic imaging and radiation therapy planning data. Individual centers may upload data remotely, but not all centers involved in the trial chose to use this system. A quality scoring system was devised based on how well the radiation therapy plan matched the protocol guidelines, to what extent deviations were justified, and whether adverse effects may result. Central review of radiation therapy planning was undertaken retrospectively in 100 patients for whom complete diagnostic and treatment sets were available. Data were reviewed and compared against protocol guidelines by an international team of radiation oncologists and radiologists. For each patient in the sample, the central review team assigned a quality assurance score. Results: It was found that in 48% of patients there was full compliance with protocol requirements. In 29%, there were deviations for justifiable reasons with no likely long-term adverse effects resulting. In 5%, deviations had occurred for justifiable reasons, but that might result in adverse effects. In 1%, there was a deviation with no discernible justification, which would not lead to long-term adverse events. In 17%, unjustified deviations were noted, with a risk of an adverse outcome resulting. Conclusions: Owing to concern over the proportion of patients in whom unjustified deviations were observed, a protocol amendment has been issued. This offers the opportunity for central review of radiation therapy plans before the start of treatment and the treating clinician a chance to modify plans.

An approach to applying quality assurance to nuclear fuel waste disposal

International Nuclear Information System (INIS)

Cooper, R.B.; Abel, R.

1996-12-01

An approach to developing and applying a quality assurance program for a nuclear fuel waste disposal facility is described. The proposed program would be based on N286-series standards used for quality assurance programs in nuclear power plants, and would cover all aspects of work across all stages of the project, from initial feasibility studies to final closure of the vault. A quality assurance manual describing the overall quality assurance program and its elements would be prepared at the outset. Planning requirements of the quality assurance program would be addressed in a comprehensive plan for the project. Like the QA manual, this plan would be prepared at the outset of the project and updated at each stage. Particular attention would be given to incorporating the observational approach in procedures for underground engineering, where the ability to adapt designs and mining techniques to changing ground conditions would be essential. Quality verification requirements would be addressed through design reviews, peer reviews, inspections and surveillance, equipment calibration and laboratory analysis checks, and testing programs. Regular audits and program reviews would help to assess the state of implementation, degree of conformance to standards, and effectiveness of the quality assurance program. Audits would be particularly useful in assessing the quality systems of contractors and suppliers, and in verifying the completion of work at the end of stages. Since a nuclear fuel waste disposal project would span a period of about 90 years, a key function of the quality assurance program would be to ensure the continuity of knowledge and the transfer of experience from one stage to another This would be achieved by maintaining a records management system throughout the life of the project, by ensuring that work procedures were documented and kept current with new technologies and practices, and by instituting training programs that made use of experience gained

77 FR 32649 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-06-01

... Scientific Review Special Emphasis Panel; Small Business: Cancer Diagnostics and Treatments. Date: June 28-29...). Contact Person: Fouad A El-Zaatari, Ph.D., Scientific Review Officer, Center for Scientific Review...

Quality Assurance for Operation of Nuclear Facilities

International Nuclear Information System (INIS)

Park, C. G.; Kwon, H. I.; Kim, K. H.; Oh, Y. W.; Lee, Y. G.; Ha, J. H.; Lim, N. J.

2008-12-01

This report describes QA activities performed within 'Quality Assurance for Nuclear facility project' and results thereof. Efforts were made to maintain and improve quality system of nuclear facilities. Varification activities whether quality system was implemented in compliance with requirements. QA department assisted KOLAS accredited testing and calibration laboratories, ISO 9001 quality system, establishment of QA programs for R and D, and carried out reviews and surveys for development of quality assurance technologies. Major items of this report are as follows : - Development and Improvement of QA Programs - QA Activities - Assessment of Effectiveness and Adequacy for QA Programs

Safety and Mission Assurance Knowledge Management Retention: Managing Knowledge for Successful Mission Operations

Science.gov (United States)

Johnson, Teresa A.

2006-01-01

Knowledge Management is a proactive pursuit for the future success of any large organization faced with the imminent possibility that their senior managers/engineers with gained experiences and lessons learned plan to retire in the near term. Safety and Mission Assurance (S&MA) is proactively pursuing unique mechanism to ensure knowledge learned is retained and lessons learned captured and documented. Knowledge Capture Event/Activities/Management helps to provide a gateway between future retirees and our next generation of managers/engineers. S&MA hosted two Knowledge Capture Events during 2005 featuring three of its retiring fellows (Axel Larsen, Dave Whittle and Gary Johnson). The first Knowledge Capture Event February 24, 2005 focused on two Safety and Mission Assurance Safety Panels (Space Shuttle System Safety Review Panel (SSRP); Payload Safety Review Panel (PSRP) and the latter event December 15, 2005 featured lessons learned during Apollo, Skylab, and Space Shuttle which could be applicable in the newly created Crew Exploration Vehicle (CEV)/Constellation development program. Gemini, Apollo, Skylab and the Space Shuttle promised and delivered exciting human advances in space and benefits of space in people s everyday lives on earth. Johnson Space Center's Safety & Mission Assurance team work over the last 20 years has been mostly focused on operations we are now beginning the Exploration development program. S&MA will promote an atmosphere of knowledge sharing in its formal and informal cultures and work processes, and reward the open dissemination and sharing of information; we are asking "Why embrace relearning the "lessons learned" in the past?" On the Exploration program the focus will be on Design, Development, Test, & Evaluation (DDT&E); therefore, it is critical to understand the lessons from these past programs during the DDT&E phase.

Creating Quality Assurance and International Transparency for Quality Assurance Agencies

DEFF Research Database (Denmark)

Kristoffersen, Dorte; Lindeberg, Tobias

2004-01-01

, on the one hand, to advance internationalisation of quality assurance of higher education, and on the other hand, allow for the differences in the national approaches to quality assurance. The paper will focus on two issues: first, the strength and weaknesses of the method employed and of the use of the ENQA......The paper presents the experiences gained in the pilot project on mutual recognition conducted by the quality assurance agencies in the Nordic countries and the future perspective for international quality assurance of national quality assurance agencies. The background of the project was the need...

Technology and Tool Development to Support Safety and Mission Assurance

Science.gov (United States)

Denney, Ewen; Pai, Ganesh

2017-01-01

The Assurance Case approach is being adopted in a number of safety-mission-critical application domains in the U.S., e.g., medical devices, defense aviation, automotive systems, and, lately, civil aviation. This paradigm refocuses traditional, process-based approaches to assurance on demonstrating explicitly stated assurance goals, emphasizing the use of structured rationale, and concrete product-based evidence as the means for providing justified confidence that systems and software are fit for purpose in safely achieving mission objectives. NASA has also been embracing assurance cases through the concepts of Risk Informed Safety Cases (RISCs), as documented in the NASA System Safety Handbook, and Objective Hierarchies (OHs) as put forth by the Agency's Office of Safety and Mission Assurance (OSMA). This talk will give an overview of the work being performed by the SGT team located at NASA Ames Research Center, in developing technologies and tools to engineer and apply assurance cases in customer projects pertaining to aviation safety. We elaborate how our Assurance Case Automation Toolset (AdvoCATE) has not only extended the state-of-the-art in assurance case research, but also demonstrated its practical utility. We have successfully developed safety assurance cases for a number of Unmanned Aircraft Systems (UAS) operations, which underwent, and passed, scrutiny both by the aviation regulator, i.e., the FAA, as well as the applicable NASA boards for airworthiness and flight safety, flight readiness, and mission readiness. We discuss our efforts in expanding AdvoCATE capabilities to support RISCs and OHs under a project recently funded by OSMA under its Software Assurance Research Program. Finally, we speculate on the applicability of our innovations beyond aviation safety to such endeavors as robotic, and human spaceflight.

Assuring quality in narrative analysis.

Science.gov (United States)

Bailey, P H

1996-04-01

Many nurse-researchers using qualitative strategies have been concerned with assuring quality in their work. The early literature reveals that the concepts of validity and reliability, as understood from the positivist perspective, are somehow inappropriate and inadequate when applied to interpretive research. More recent literature suggests that because of the positivist and interpretive paradigms are epistemologically divergent, the transfer of quality criteria from one perspective to the other is not automatic or even reasonable. The purpose of this article, therefore, is to clarify what the terms quality, trustworthiness, credibility, authenticity, and goodness mean in qualitative research findings. The process of assuring quality, validation, in qualitative research will be discussed within the context of the interpretive method, narrative analysis. A brief review of quality in narrative analysis nursing research will also be presented.

[Quality assurance in occupational health services].

Science.gov (United States)

Michalak, J

1996-01-01

The general conditions influencing the quality assurance and audit in Polish occupational health services are presented. The factors promoting or hampering the implementation of quality assurance and audits are also discussed. The major influence on the transformation of Polish occupational health services in exorted by employers who are committed to cover the costs of the obligatory prophylactic examination of their employees. This is the factor which also contributes to the improvement of quality if services. The definitions of the most important terms are reviewed to highlight their accordance with the needs of occupational health services in Poland. The examples of audit are presented and the elements of selected methods of auditing are suggested to be adopted in Poland.

EORTC Radiation Oncology Group quality assurance platform: Establishment of a digital central review facility

International Nuclear Information System (INIS)

Fairchild, Alysa; Aird, Edwin; Fenton, Paul A.; Gregoire, Vincent; Gulyban, Akos; Lacombe, Denis; Matzinger, Oscar; Poortmans, Philip; Ruyskart, Pascal; Weber, Damien C.; Hurkmans, Coen W.

2012-01-01

Objective: Quality assurance (QA) in clinical trials is essential to ensure treatment is safely and effectively delivered. As QA requirements have increased in complexity in parallel with evolution of radiation therapy (RT) delivery, a need to facilitate digital data exchange emerged. Our objective is to present the platform developed for the integration and standardization of QART activities across all EORTC trials involving RT. Methods: The following essential requirements were identified: secure and easy access without on-site software installation; integration within the existing EORTC clinical remote data capture system; and the ability to both customize the platform to specific studies and adapt to future needs. After retrospective testing within several clinical trials, the platform was introduced in phases to participating sites and QART study reviewers. Results: The resulting QA platform, integrating RT analysis software installed at EORTC Headquarters, permits timely, secure, and fully digital central DICOM-RT based data review. Participating sites submit data through a standard secure upload webpage. Supplemental information is submitted in parallel through web-based forms. An internal quality check by the QART office verifies data consistency, formatting, and anonymization. QART reviewers have remote access through a terminal server. Reviewers evaluate submissions for protocol compliance through an online evaluation matrix. Comments are collected by the coordinating centre and institutions are informed of the results. Conclusions: This web-based central review platform facilitates rapid, extensive, and prospective QART review. This reduces the risk that trial outcomes are compromised through inadequate radiotherapy and facilitates correlation of results with clinical outcomes.

Neonatal Outcomes in the Birth Center Setting: A Systematic Review.

Science.gov (United States)

Phillippi, Julia C; Danhausen, Kathleen; Alliman, Jill; Phillippi, R David

2018-01-01

This systematic review investigates the effect of the birth center setting on neonatal mortality in economically developed countries to aid women and clinicians in decision making. We searched the Google Scholar, CINAHL, and PubMed databases using key terms birth/birthing center or out of hospital with perinatal/neonatal outcomes. Ancestry searches identified additional studies, and an alert was set for new publications. We included primary source studies in English, published after 1980, conducted in a developed country, and researching planned birth in centers with guidelines similar to American Association of Birth Centers standards. After initial review, we conducted a preliminary analysis, assessing which measures of neonatal health, morbidity, and mortality were included across studies. Neonatal mortality was selected as the sole summary measure as other measures were sporadically reported or inconsistently defined. Seventeen studies were included, representing at least 84,500 women admitted to a birth center in labor. There were substantial differences of study design, sampling techniques, and definitions of neonatal outcomes across studies, limiting conclusive statements of the effect of intrapartum care in a birth center. No reviewed study found a statistically increased rate of neonatal mortality in birth centers compared to low-risk women giving birth in hospitals, nor did data suggest a trend toward higher neonatal mortality in birth centers. As in all birth settings, nulliparous women, women aged greater than 35 years, and women with pregnancies of more than 42 weeks' gestation may have an increased risk of neonatal mortality. There are substantial flaws in the literature concerning the effect of birth center care on neonatal outcomes. More research is needed on subgroups at risk of poor outcomes in the birth center environment. To expedite research, consistent use of national and international definitions of perinatal and neonatal mortality within

Clinical implementation and quality assurance for intensity modulated radiation therapy

International Nuclear Information System (INIS)

Ma, C.-M.; Price, R.; McNeeley, S.; Chen, L.; Li, J.S.; Wang, L.; Ding, M.; Fourkal, E.; Qin, L.

2002-01-01

This paper describes the clinical implementation and quality assurance (QA) for intensity-modulated radiation therapy (IMRT) based on the experience at Fox Chase Cancer Center, Philadelphia, USA. We will review our procedures for the clinical implementation of the IMRT technique and the requirements for patient immobilization, target delineation, treatment optimization, beam delivery and system administration. We will discuss the dosimetric requirements and measurement procedures for beam commissioning and dosimetry verification for IMRT. We will examine the details of model-based dose calculation for IMRT treatment planning and the potential problems with such dose calculation algorithms. We will discuss the effect of beam delivery systems on the actual dose distributions received by the patients and the methods to incorporate such effects in the treatment optimization process. We will investigate the use of the Monte Carlo method for dose calculation and treatment verification for IMRT

Report on probabilistic safety assessment (PSA) quality assurance in utilization of risk information

International Nuclear Information System (INIS)

2006-12-01

Recently in Japan, introduction of nuclear safety regulations using risk information such as probabilistic safety assessment (PSA) has been considered and utilization of risk information in the rational and practical measures on safety assurance has made a progress to start with the operation or inspection area. The report compiled results of investigation and studies of PSA quality assurance in risk-informed activities in the USA. Relevant regulatory guide and standard review plan as well as issues and recommendations were reviewed for technical adequacy and advancement of probabilistic risk assessment technology in risk-informed decision making. Useful and important information to be referred as issues in PSA quality assurance was identified. (T. Tanaka)

Safety and Mission Assurance Knowledge Management Retention

Science.gov (United States)

Johnson, Teresa A.

2006-01-01

This viewgraph presentation reviews the issues surrounding the management of knowledge in regards to safety and mission assurance. The JSC workers who were hired in the 1960's are slated to retire in the next two to three years. The experiences and knowledge of these NASA workers must be identified, and disseminated. This paper reviews some of the strategies that the S&MA is developing to capture that valuable institutional knowledge.

Assuring consumer information and protection in the solar market: need, status, strategy

Energy Technology Data Exchange (ETDEWEB)

1981-10-01

In this report the Consumer Energy Council has examined a number of basic issues affecting consumer assurance in the solar market. A general framework has been established to specify the role of consumer assurance as it relates both to government activity and a new consumer product industry. The available empirical evidence has been reviewed to identify the actual needs for consumer assurance in the solar market. By synthesizing the work of the SOLCAN Planning Project participants we have identified both the general thrust of existing consumer assurance mechanisms in the states and the direction that efforts to improve and expand those mechanisms are likely to take. Finally, several brief recommendations for combining the pieces of consumer assurance into an effective overall framework have been put forward.

High assurance SPIRAL

Science.gov (United States)

Franchetti, Franz; Sandryhaila, Aliaksei; Johnson, Jeremy R.

2014-06-01

In this paper we introduce High Assurance SPIRAL to solve the last mile problem for the synthesis of high assurance implementations of controllers for vehicular systems that are executed in today's and future embedded and high performance embedded system processors. High Assurance SPIRAL is a scalable methodology to translate a high level specification of a high assurance controller into a highly resource-efficient, platform-adapted, verified control software implementation for a given platform in a language like C or C++. High Assurance SPIRAL proves that the implementation is equivalent to the specification written in the control engineer's domain language. Our approach scales to problems involving floating-point calculations and provides highly optimized synthesized code. It is possible to estimate the available headroom to enable assurance/performance trade-offs under real-time constraints, and enables the synthesis of multiple implementation variants to make attacks harder. At the core of High Assurance SPIRAL is the Hybrid Control Operator Language (HCOL) that leverages advanced mathematical constructs expressing the controller specification to provide high quality translation capabilities. Combined with a verified/certified compiler, High Assurance SPIRAL provides a comprehensive complete solution to the efficient synthesis of verifiable high assurance controllers. We demonstrate High Assurance SPIRALs capability by co-synthesizing proofs and implementations for attack detection and sensor spoofing algorithms and deploy the code as ROS nodes on the Landshark unmanned ground vehicle and on a Synthetic Car in a real-time simulator.

Management assessments of Quality Assurance Program implementation effectiveness

International Nuclear Information System (INIS)

Snyder, D.A.

1984-01-01

This paper describes a method currently being used by UNC Nuclear Industries, Richland, Washington, to help assure the effectiveness of Quality Assurance (QA) Program implementation. Assessments are conducted annually by management in each department, and the results summarized to the president and his staff. The purpose of these assessments is to review the adequacy of the department's implementing procedures, training/instruction on implementing procedures, and procedure implementation effectiveness. The primary purpose is to assess effectiveness and take improvement action where the need is indicated. The QA organization provides only general guidance in conducting the assessments

75 FR 37453 - Center for Scientific Review; Notice of Closed Meeting

Science.gov (United States)

2010-06-29

...: Cognition, Language and Perception. Date: July 12, 2010. Time: 8 a.m. to 6 p.m. Agenda: To review and... Francisco, CA 94108. Contact Person: Weijia Ni, PhD, Scientific Review Officer, Center for Scientific Review...

75 FR 80511 - Center for Scientific Review; Notice of Closed Meeting

Science.gov (United States)

2010-12-22

...: Cognition and Perception. Date: January 19-20, 2011. Time: 12 p.m. to 6 p.m. Agenda: To review and evaluate... (Virtual Meeting). Contact Person: Weijia Ni, PhD, Scientific Review Officer, Center for Scientific Review...

78 FR 16860 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-03-19

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Neuronal... Scientific Review Special Emphasis Panel; Member Conflict: Endocrinology, Metabolism, Nutrition and...

Dose Specification and Quality Assurance of Radiation Therapy Oncology Group Protocol 95-17; a Cooperative Group Study of Iridium-192 Breast Implants as Sole Therapy

International Nuclear Information System (INIS)

Ibbott, Geoffrey S.; Hanson, W.F.; O'Meara, Elizabeth; Kuske, Robert R.; Arthur, Douglas; Rabinovitch, Rachel; White, Julia; Wilenzick, Raymond M.; Harris, Irene; Tailor, Ramesh C.

2007-01-01

Purpose: The Radiation Therapy Oncology Group (RTOG) protocol 95-17 was a Phase I/II trial to evaluate multicatheter brachytherapy as the sole method of adjuvant breast radiotherapy for Stage I/II breast carcinoma after breast-conserving surgery. Low- or high-dose-rate sources were allowed. Dose prescription and treatment evaluation were based on recommendations in the International Commission on Radiation Units and Measurements (ICRU), Report 58 and included the parameters mean central dose (MCD), average peripheral dose, dose homogeneity index (DHI), and the dimensions of the low- and high-dose regions. Methods and Materials: Three levels of quality assurance were implemented: (1) credentialing of institutions was required before entering patients into the study; (2) rapid review of each treatment plan was conducted before treatment; and (3) retrospective review was performed by the Radiological Physics Center in conjunction with the study chairman and RTOG dosimetry staff. Results: Credentialing focused on the accuracy of dose calculation algorithm and compliance with protocol guidelines. Rapid review was designed to identify and correct deviations from the protocol before treatment. The retrospective review involved recalculation of dosimetry parameters and review of dose distributions to evaluate the treatment. Specifying both central and peripheral doses resulted in uniform dose distributions, with a mean dose homogeneity index of 0.83 ± 0.06. Conclusions: Vigorous quality assurance resulted in a high-quality study with few deviations; only 4 of 100 patients were judged as representing minor variations from protocol, and no patient was judged as representing major deviation. This study should be considered a model for quality assurance of future trials

76 FR 30372 - Center for Scientific Review; Meetings

Science.gov (United States)

2011-05-25

... Panel; Member Conflict: Speech and Cognition. Date: June 9-10, 2011. Time: 11 a.m. to 5 p.m. Agenda: To....gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Emotion...

Evaluation of the New DIN Standard for Quality Assurance of Diagnostic Displays - Technical Review DIN 6868-157.

Science.gov (United States)

Entz, Kathrin; Sommer, Alexander; Lenzen, Horst

2018-01-01

Acceptance and regular constancy tests are necessary to ensure the quality of diagnostic displays. In November 2014, a new standard (DIN 6868-157) was published which defines the test procedure and limiting values. There are several substantial changes compared with the previous standard DIN V 6868-57, i. e. considering the complete image display system including workstation and application software instead of only the displays. Since its publication, the new standard has raised many questions. This technical review aims to show the strengths and weaknesses of the new standard. Positive aspects are the introduction of a limiting value for the illuminance and the extension of the interval for constancy tests from 3 to 6 six months. The daily constancy test on the other hand, raises several problems and should be replaced by a randomized test. Additionally, the medical relevance is critically questioned and an overview of software for the quality assurance will be given.   · Acceptance and constancy tests for diagnostic displays are defined in DIN 6868-157.. · The new standards has positive and negative aspects.. · Randomized tests should be introduced.. · Entz K, Sommer A, Lenzen H. DIN 6868-157: Image Quality Assurance in Diagnostic X-ray Departments - X-ray Ordinance Acceptance and Constancy Test of Image Display Systems in their Environment - Technical Review -. Fortschr Röntgenstr 2018; 190: 51 - 60. © Georg Thieme Verlag KG Stuttgart · New York.

75 FR 27794 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-05-18

... Committee: Immunology Integrated Review Group; Transplantation, Tolerance, and Tumor Immunology Study...: Center for Scientific Review Special Emphasis Panel; Special Topics: Bacterial Pathogenesis. Date: [email protected] . Name of Committee: Immunology Integrated Review Group; Cellular and Molecular Immunology...

75 FR 31798 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-06-04

... Beach and Executive Meeting Center, 701 West Ocean Boulevard, Long Beach, CA 90831. Contact Person...: Center for Scientific Review Special Emphasis Panel, ARRA: Risk Prevention and Health Behavior Across the...

Quality assurance and demolition: 2008 symposium

International Nuclear Information System (INIS)

Schartmann, F.; Thierfeldt, S.

2008-01-01

The 'Quality Assurance and Demolition Symposium, which has become a tradition established jointly by Applus RTD Deutschland GmbH (formerly compra GmbH) and Brenk Systemplanung GmbH, Aachen, was held also in 2008 with the focus on quality assurance and the demolition of nuclear facilities. The conference began with a series of lectures on knowledge and document management in general, and the use of document management systems in the nuclear field in particular. The evening lecture was presented by Axel Weis (Karlsruhe Research Center) on 'Competence Preservation in Nuclear Technology'. The 24 technical papers presented on the next 2 days of the symposium dealt with non-destructive materials testing and with special problems of radiation protection, demolition, and waste management. In 2009, the meeting will cover similar main topics and will again be held in an interesting environment, perhaps in combination with a tour of a demolition project. (orig.)

Creating Quality Assurance and International Transparency for Quality Assurance Agencies

DEFF Research Database (Denmark)

Kristoffersen, Dorte; Lindeberg, Tobias

2004-01-01

The paper presents the experiences gained in the pilot project on mutual recognition conducted by the quality assurance agencies in the Nordic countries and the future perspective for international quality assurance of national quality assurance agencies. The background of the project was the nee...

Quality assurance and quality control in mammography: a review of available guidance worldwide.

Science.gov (United States)

Reis, Cláudia; Pascoal, Ana; Sakellaris, Taxiarchis; Koutalonis, Manthos

2013-10-01

Review available guidance for quality assurance (QA) in mammography and discuss its contribution to harmonise practices worldwide. Literature search was performed on different sources to identify guidance documents for QA in mammography available worldwide in international bodies, healthcare providers, professional/scientific associations. The guidance documents identified were reviewed and a selection was compared for type of guidance (clinical/technical), technology and proposed QA methodologies focusing on dose and image quality (IQ) performance assessment. Fourteen protocols (targeted at conventional and digital mammography) were reviewed. All included recommendations for testing acquisition, processing and display systems associated with mammographic equipment. All guidance reviewed highlighted the importance of dose assessment and testing the Automatic Exposure Control (AEC) system. Recommended tests for assessment of IQ showed variations in the proposed methodologies. Recommended testing focused on assessment of low-contrast detection, spatial resolution and noise. QC of image display is recommended following the American Association of Physicists in Medicine guidelines. The existing QA guidance for mammography is derived from key documents (American College of Radiology and European Union guidelines) and proposes similar tests despite the variations in detail and methodologies. Studies reported on QA data should provide detail on experimental technique to allow robust data comparison. Countries aiming to implement a mammography/QA program may select/prioritise the tests depending on available technology and resources. •An effective QA program should be practical to implement in a clinical setting. •QA should address the various stages of the imaging chain: acquisition, processing and display. •AEC system QC testing is simple to implement and provides information on equipment performance.

77 FR 8270 - Center For Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-02-14

... Scientific Review Special Emphasis Panel; Small Business: Diabetes, Obesity and Reproductive Sciences. Date... Committee: Center for Scientific Review Special Emphasis Panel; Fellowships: Sensory and Motor Neuroscience...

77 FR 28397 - Center for Scientific Review Notice of Closed Meetings

Science.gov (United States)

2012-05-14

...: Integrative, Functional and Cognitive Neuroscience Integrated Review Group, Somatosensory and Chemosensory....gov . Name of Committee: Integrative, Functional and Cognitive Neuroscience Integrated Review Group..., [email protected] . Name of Committee: Center for Scientific Review Special Emphasis Panel, AREA (R15...

78 FR 312 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-01-03

...: Digestive, Kidney and Urological Systems Integrated Review Group Clinical, Integrative and Molecular....nih.gov . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...

77 FR 14955 - DoD Information Assurance Scholarship Program (IASP)

Science.gov (United States)

2012-03-14

... point of contact at each CAE, responsible for publicizing the DoD IASP to potential recruitment students... college or university to NSA. Centers of Academic Excellence in Information Assurance Education and... proposal, and all colleges and universities subsequently receiving grants must provide documentation on how...

Enhancing Treatment Outcome of Patients at Risk of Treatment Failure: Meta-Analytic and Mega-Analytic Review of a Psychotherapy Quality Assurance System

Science.gov (United States)

Shimokawa, Kenichi; Lambert, Michael J.; Smart, David W.

2010-01-01

Objective: Outcome research has documented worsening among a minority of the patient population (5% to 10%). In this study, we conducted a meta-analytic and mega-analytic review of a psychotherapy quality assurance system intended to enhance outcomes in patients at risk of treatment failure. Method: Original data from six major studies conducted…

77 FR 65567 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-10-29

... for Scientific Review Special Emphasis Panel; PAR Panel: Newborn Disorders. Date: November 28, 2012... . Name of Committee: Center for Scientific Review Special Emphasis Panel; Gastrointestinal, Kidney and...

76 FR 6805 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-02-08

... Committee: Center for Scientific Review Special Emphasis Panel; Small Business: Immunology. Date: March 10... Scientific Review Special Emphasis Panel; Member Conflict: Topics on Infectious Diseases and Microbiology...

76 FR 3643 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-01-20

... for Scientific Review Special Emphasis Panel, Societal and Ethical Issues in Research. Date: February... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Neuroscience Integrated Review Group, Synapses, Cytoskeleton and Trafficking Study Section. Date: February 10...

77 FR 27470 - Center for Scientific Review Notice of Closed Meetings

Science.gov (United States)

2012-05-10

...: Bioengineering Sciences & Technologies Integrated Review Group; Nanotechnology Study Section. Date: June 7-8... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: Risk, Prevention and Health Behavior Integrated Review Group; Risk...

Quality-assurance approach for the Elmo Bumpy Torus Proof-of-Principal experiment

International Nuclear Information System (INIS)

Sticksel, F.M.

1981-01-01

Components, subsystems and systems will be subjected to inspection and test as necessary to ensure compliance to applicable specifications, Acceptance Test Procedures and/or customer requirements. Quality Assurance will inspect each component, subsystem and system for selected mechanical and electrical defects. In addition, Quality Assurance will either perform, or verify performance of, and analyze, or verify analysis of, all required field and laboratory tests. If hardware is modified, repaired or replaced after final testing, necessary re-inspection and retest must be performed. Insofar as possible the component, subsystem or system will be released as acceptable upon completion of these activities. When nonconformances are detected during the course of site surveillance activities, MDAC or Gilbert/Commonwealth will initiate a Nonconformance Record for review by MDAC Quality Assurance and Project Engineering personnel. These nonconformances will be identified and dispositioned per MDAC Standard Practices with the advice and concurrence of Gilbert/Commonwealth personnel, if deemed appropriate. MDAC Quality Assurance personnel will witness the pre-operational testing and review the test data

Assuring Quality in Online Course Delivery

Science.gov (United States)

Matuga, Julia M.; Wooldridge, Deborah G.; Poirier, Sandra

2011-01-01

This paper examines the critical issue of assuring quality online course delivery by examining four key components of online teaching and learning. The topic of course delivery is viewed as a cultural issue that permeates processes from the design of an online course to its evaluation. First, the authors examine and review key components of and…

Quality assurance during site construction. Pt. 1

International Nuclear Information System (INIS)

Mueller, J.

1980-01-01

The first part of the lecture deals with the Quality Assurance system on the construction site in general. Basic site-related problems during contract implementation and the QA system requirements resulting from them are presented. The compilation of these requirements in a QA program and its inclusion in the site manual in written form are explained. Site organization, personnel qualification and procedures are referred to. Whereas the first part shows what is to be done, the second part shows how it can be put into practice on the site. All the essential points for the assurance of quality are addressed. They include, e.g., review of documents, incoming goods control, in-process surveillance, store controls, identification of components and systems, dealing with changes and deviations, documentation control and audits. By means of examples taken form practice the necessity of a well-functioning QA system, and the importance of quality-assuring measures on the site are pointed out. (orig.)

Trauma Center Based Youth Violence Prevention Programs: An Integrative Review.

Science.gov (United States)

Mikhail, Judy Nanette; Nemeth, Lynne Sheri

2016-12-01

Youth violence recidivism remains a significant public health crisis in the United States. Violence prevention is a requirement of all trauma centers, yet little is known about the effectiveness of these programs. Therefore, this systematic review summarizes the effectiveness of trauma center-based youth violence prevention programs. A systematic review of articles from MEDLINE, CINAHL, and PsychINFO databases was performed to identify eligible control trials or observational studies. Included studies were from 1970 to 2013, describing and evaluating an intervention, were trauma center based, and targeted youth injured by violence (tertiary prevention). The social ecological model provided the guiding framework, and findings are summarized qualitatively. Ten studies met eligibility requirements. Case management and brief intervention were the primary strategies, and 90% of the studies showed some improvement in one or more outcome measures. These results held across both social ecological level and setting: both emergency department and inpatient unit settings. Brief intervention and case management are frequent and potentially effective trauma center-based violence prevention interventions. Case management initiated as an inpatient and continued beyond discharge was the most frequently used intervention and was associated with reduced rearrest or reinjury rates. Further research is needed, specifically longitudinal studies using experimental designs with high program fidelity incorporating uniform direct outcome measures. However, this review provides initial evidence that trauma centers can intervene with the highest of risk patients and break the youth violence recidivism cycle. © The Author(s) 2015.

76 FR 24894 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-05-03

... Sciences Integrated Review Group; Arthritis, Connective Tissue and Skin Study Section. Date: June [email protected] . Name of Committee: Center for Scientific Review Special Emphasis Panel; Cancer Genetics...

78 FR 2681 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-01-14

...-435-1212, [email protected] . Name of Committee: Immunology Integrated Review Group; Innate Immunity... Scientific Review Special Emphasis Panel; Member Conflicts: Pain and Hearing Date: February 12-13, 2013. Time... Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Radiation Oncology. Date...

75 FR 4090 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-01-26

... El Camino Real, San Diego, CA 92130. Contact Person: William A. Greenberg, PhD., Scientific Review... (Virtual Meeting). Contact Person: Fouad A. El-Zaatari, PhD., Scientific Review Officer, Center for... for Scientific Review Special Emphasis Panel, Small Business: Experimental Cancer Therapeutics. Date...

75 FR 54638 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-09-08

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Selected Topics...: Immunology Integrated Review Group, Innate Immunity and Inflammation Study Section. Date: October 14-15, 2010... 20892. 301-594-6830. [email protected] . Name of Committee: Immunology Integrated Review Group...

76 FR 24897 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-05-03

...: Bioengineering Sciences & Technologies Integrated Review Group, Nanotechnology Study Section. Date: June 9-10... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Biophysics Integrated Review Group, Macromolecular Structure and Function A Study Section. Date: June 2, 2011...

78 FR 29373 - Center For Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-05-20

[email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center For Scientific Review... Neuroscience Integrated Review Group; Diseases and Pathophysiology of the Visual System Study Section. Date...

76 FR 6486 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-02-04

...: Center for Scientific Review Special Emphasis Panel; RFA Panel: Topics in Bacterial Pathogenesis. Date... Scientific Review Special Emphasis Panel; Neurodegeneration, Trauma, Immunology and Imaging. Date: March 7-8... 6487

75 FR 32956 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-06-10

...: Center for Scientific Review Special Emphasis Panel, Member Conflict: Bone and Cartilage Biology. Date... Review Special Emphasis Panel, Small Business: Cell Biology and Molecular Imaging. Date: June 30, 2010...

Recommendations for a software quality assurance policy for the nuclear waste disposal risk assessment programme

International Nuclear Information System (INIS)

Hill, I.E.

1985-05-01

This study reviewed a number of published standards for software quality assurance, and included a series of interviews with software developers aimed at exploring their attitudes to software quality assurance. Recommendations for software quality assurance policy are made based on the above investigations. This document provides a summary of the recommendations made in the full report on project, reference MR-CDS-4. (author)

Results of a Quality Assurance Review of External Beam Radiation Therapy in the International Society of Paediatric Oncology (Europe) Neuroblastoma Group's High-risk Neuroblastoma Trial: A SIOPEN Study

Energy Technology Data Exchange (ETDEWEB)

Gaze, Mark N., E-mail: mark.gaze@uclh.nhs.uk [Department of Oncology, University College London Hospitals NHS Foundation Trust, London (United Kingdom); Boterberg, Tom [Department of Radiation Oncology, Ghent University Hospital, Ghent (Belgium); Dieckmann, Karin; Hoermann, Marcus [General Hospital Vienna, Medical University Vienna (Austria); Gains, Jennifer E.; Sullivan, Kevin P. [Department of Oncology, University College London Hospitals NHS Foundation Trust, London (United Kingdom); Ladenstein, Ruth [Children' s Cancer Research Institute, St. Anna Children' s Hospital, Vienna (Austria)

2013-01-01

Purpose: Radiation therapy is important for local control in neuroblastoma. This study reviewed the compliance of plans with the radiation therapy guidelines of the International Society of Paediatric Oncology (Europe) Neuroblastoma Group (SIOPEN) High-Risk Trial protocol. Methods and Materials: The SIOPEN trial central electronic database has sections to record diagnostic imaging and radiation therapy planning data. Individual centers may upload data remotely, but not all centers involved in the trial chose to use this system. A quality scoring system was devised based on how well the radiation therapy plan matched the protocol guidelines, to what extent deviations were justified, and whether adverse effects may result. Central review of radiation therapy planning was undertaken retrospectively in 100 patients for whom complete diagnostic and treatment sets were available. Data were reviewed and compared against protocol guidelines by an international team of radiation oncologists and radiologists. For each patient in the sample, the central review team assigned a quality assurance score. Results: It was found that in 48% of patients there was full compliance with protocol requirements. In 29%, there were deviations for justifiable reasons with no likely long-term adverse effects resulting. In 5%, deviations had occurred for justifiable reasons, but that might result in adverse effects. In 1%, there was a deviation with no discernible justification, which would not lead to long-term adverse events. In 17%, unjustified deviations were noted, with a risk of an adverse outcome resulting. Conclusions: Owing to concern over the proportion of patients in whom unjustified deviations were observed, a protocol amendment has been issued. This offers the opportunity for central review of radiation therapy plans before the start of treatment and the treating clinician a chance to modify plans.

DOE'S remedial action assurance program

International Nuclear Information System (INIS)

Welty, C.G. Jr.; Needels, T.S.; Denham, D.H.

1984-10-01

The formulation and initial implementation of DOE's Assurance Program for Remedial Action are described. It was initiated in FY 84 and is expected to be further implemented in FY 85 as the activities of DOE's Remedial Action programs continue to expand. Further APRA implementation will include additional document reviews, site inspections, and program office appraisals with emphasis on Uranium Mill Tailings Remedial Action Program and Surplus Facilities Management Program

Revitalizing quality assurance

International Nuclear Information System (INIS)

Hawkins, F.C.

1998-01-01

The image of someone inspecting or auditing often comes to mind when people hear the term quality assurance. Although partially correct, this image is not the complete picture. The person doing the inspecting or auditing is probably part of a traditional quality assurance organization, but that organization is only one aspect of a properly conceived and effectively implemented quality assurance system whose goal is improved facility safety and reliability. This paper introduces the underlying philosophies and basic concepts of the International Atomic Energy Agency's new quality assurance initiative that began in 1991 as part of a broad Agency-wide program to enhance nuclear safety. The first product of that initiative was publication in 1996 of a new Quality Assurance Code 50-C/SG-Q and fourteen related Safety Guides. This new suite of documents provide the technical and philosophical foundation upon which Member States can base their quality assurance programs. (author)

77 FR 8269 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-02-14

.... Place: Mayflower Park Hotel, 405 Olive Way, Seattle, WA 98101. Contact Person: Rebecca Henry, Ph.D... 20814. Contact Person: Melinda Jenkins, Ph.D., Scientific Review Officer, Center for Scientific Review...

Introduction to quality assurance

International Nuclear Information System (INIS)

Kaden, W.

1980-01-01

In today's interpretation 'quality assurance' means 'good management'. Quality assurance has to cover all phases of a work, but all quality assurance measures must be adapted to the relevance and complexity of the actual task. Examples are given for the preparation of quality classes, the organization of quality assurance during design and manufacturing and for auditing. Finally, efficiency and limits of quality assurance systems are described. (orig.)

Quality assurance procedures for mass spectrometry untargeted metabolomics. a review.

Science.gov (United States)

Dudzik, Danuta; Barbas-Bernardos, Cecilia; García, Antonia; Barbas, Coral

2018-01-05

Untargeted metabolomics, as a global approach, has already proven its great potential and capabilities for the investigation of health and disease, as well as the wide applicability for other research areas. Although great progress has been made on the feasibility of metabolomics experiments, there are still some challenges that should be faced and that includes all sources of fluctuations and bias affecting every step involved in multiplatform untargeted metabolomics studies. The identification and reduction of the main sources of unwanted variation regarding the pre-analytical, analytical and post-analytical phase of metabolomics experiments is essential to ensure high data quality. Nowadays, there is still a lack of information regarding harmonized guidelines for quality assurance as those available for targeted analysis. In this review, sources of variations to be considered and minimized along with methodologies and strategies for monitoring and improvement the quality of the results are discussed. The given information is based on evidences from different groups among our own experiences and recommendations for each stage of the metabolomics workflow. The comprehensive overview with tools presented here might serve other researchers interested in monitoring, controlling and improving the reliability of their findings by implementation of good experimental quality practices in the untargeted metabolomics study. Copyright © 2017 Elsevier B.V. All rights reserved.

76 FR 10912 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-02-28

... 22202. Contact Person: Lawrence E Boerboom, PhD, Scientific Review Officer, Center for Scientific Review... Institutes of Health, HHS) Dated: February 18, 2011. Jennifer S. Spaeth, Director, Office of Federal Advisory...

Quality assurance

International Nuclear Information System (INIS)

Kunich, M.P.; Vieth, D.L.

1989-01-01

This paper provides a point/counterpoint view of a quality assurance director and a project manager. It presents numerous aspects of quality assurance requirements along with analyses as to the value of each

75 FR 41505 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-07-16

... for Scientific Review Special Emphasis Panel; Mass Spectrometry Shared Instrumentation Study Section... Instrumentation: Mass Spectrometers. Date: August 5-6, 2010. Time: 8:30 a.m. to 5 p.m. Agenda: To review and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...

78 FR 109 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-01-02

... personal privacy. Name of Committee: Bioengineering Sciences & Technologies Integrated Review Group Nanotechnology Study Section. Date: January 31-February 1, 2013. Time: 7:00 a.m. to 5:00 p.m. Agenda: To review... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...

75 FR 32487 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-06-08

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... for Scientific Review Special Emphasis Panel; Small Business: Biomaterials, Delivery Systems, and... Digestive Diseases and Nutrition. Date: June 28-29, 2010. Time: 8 a.m. to 5 p.m. Agenda: To review and...

77 FR 54583 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-09-05

[email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Integrated Review Group, Aging Systems and Geriatrics Study Section. Date: October 8, 2012. Time: 8 a.m. to 6...

A review of the recommendations governing quality assurance of ultrasound systems used for guidance in prostate brachytherapy.

Science.gov (United States)

Doyle, Andrea Jane; King, Deirdre M; Browne, Jacinta E

2017-12-01

Ultrasound guided brachytherapy for the treatment of prostate cancer has become a routine treatment option, due to many benefits including patient recovery and dose localisation [1]; however it is not clear whether the standards which govern the image quality for these systems are adequate. Upon review of the recommended standards for ultrasound systems used in prostate brachytherapy procedures, the recommended tests do not appear to be specific to the clinical application of ultrasound guided prostate brachytherapy. Rather they are generic and similar to those recommended for other clinical applications such as general abdominal scanning [2]. Furthermore, there is growing evidence that these tests should be specific to the clinical application [3,4] in order to gain meaningful data about the performance of the system for the application, and also to detect clinically relevant changes in quality control results. An additional problem is that there are no clinically relevant test phantom recommended for the quality assurance of ultrasound systems used in prostate brachytherapy. The image quality for this application of ultrasound needs to be monitored to ensure consistent levels of confidence in the procedure. This paper reviews the currently recommended test guidelines and test phantoms for ultrasound systems used in prostate brachytherapy from the different standard bodies and professional organisations. A critical analysis of those tests which are most reflective of the imaging and guidance tasks undertaken in an ultrasound guided prostate brachytherapy procedure will also be presented to inform the design of a TRUS quality assurance protocol. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Multinational Quality Assurance

Science.gov (United States)

Kinser, Kevin

2011-01-01

Multinational colleges and universities pose numerous challenges to the traditional models of quality assurance that are designed to validate domestic higher education. When institutions cross international borders, at least two quality assurance protocols are involved. To guard against fraud and abuse, quality assurance in the host country is…

75 FR 2877 - Center For Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-01-19

..., CA 92109. Contact Person Paek-Gyu Lee, PhD, Scientific Review Officer, Center for Scientific Review...: Hotel Monaco, 700 F Street, NW., Washington, DC 20004. Contact Person Peter B. Guthrie, PhD, Scientific...

78 FR 32670 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-05-31

... Special Emphasis Panel; Cancer Diagnostics and Treatments (CDT). Date: June 27-28, 2013. Time: 8:00 a.m...). Contact Person: ouad A El-Zaatari, Ph.D., Scientific Review Officer, Center for Scientific Review...

Application of NASA Kennedy Space Center System Assurance Analysis methodology to nuclear power plant systems designs

International Nuclear Information System (INIS)

Page, D.W.

1985-01-01

In May of 1982, the Kennedy Space Center (KSC) entered into an agreement with the NRC to conduct a study to demonstrate the feasibility and practicality of applying the KSC System Assurance Analysis (SAA) methodology to nuclear power plant systems designs. North Carolina's Duke Power Company expressed an interest in the study and proposed the nuclear power facility at CATAWBA for the basis of the study. In joint meetings of KSC and Duke Power personnel, an agreement was made to select two CATAWBA systems, the Containment Spray System and the Residual Heat Removal System, for the analyses. Duke Power provided KSC with a full set of Final Safety Analysis Reports (FSAR) as well as schematics for the two systems. During Phase I of the study the reliability analyses of the SAA were performed. During Phase II the hazard analyses were performed. The final product of Phase II is a handbook for implementing the SAA methodology into nuclear power plant systems designs. The purpose of this paper is to describe the SAA methodology as it applies to nuclear power plant systems designs and to discuss the feasibility of its application. (orig./HP)

Quality assurance of nuclear energy

International Nuclear Information System (INIS)

1994-12-01

It consists of 14 chapters, which are outline of quality assurance of nuclear energy, standard of quality assurance, business quality assurance, design quality assurance, purchase quality assurance, production quality assurance, a test warranty operation warranty, maintenance warranty, manufacture of nuclear power fuel warranty, computer software warranty, research and development warranty and quality audit.

77 FR 4049 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-01-26

...: Digestive, Kidney and Urological Systems Integrated Review Group, Urologic and Genitourinary Physiology and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Delivery Systems Study Section. Date: February 23-24, 2012. Time: 8 a.m. to 5 p.m. Agenda: To review and...

77 FR 55851 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-09-11

..., [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Systems Development Study Section. Date: October 10-11, 2012. Time: 8 a.m. to 5 p.m. Agenda: To review and...

75 FR 10291 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-03-05

..., Skeletal Muscle Pathologies. Date: March 30, 2010. Time: 2 p.m. to 4 p.m. Agenda: To review and evaluate... Committee: Center for Scientific Review Special Emphasis Panel, Small Business: Skeletal Muscle. Date: March...

77 FR 8888 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-02-15

... . Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Cell Biology...: Cancer Therapeutics. Date: March 6, 2012. Time: 2 p.m. to 3 p.m. Agenda: To review and evaluate grant...

[Quality assurance in head and neck medical oncology].

Science.gov (United States)

Digue, Laurence; Pedeboscq, Stéphane

2014-05-01

In medical oncology, how can we be sure that the right drug is being administered to the right patient at the right time? The implementation of quality assurance criteria is important in medical oncology, in order to ensure that the patient receives the best treatment safely. There is very little literature about quality assurance in medical oncology, as opposed to radiotherapy or cancer surgery. Quality assurance must cover the entire patient care process, from the diagnosis, to the therapeutic decision and drug distribution, including its selection, its preparation and its delivery to the patient (administration and dosage), and finally the potential side effects and their management. The dose-intensity respect is crucial, and its reduction can negatively affect overall survival rates, as shown in breast and testis cancers for example. In head and neck medical oncology, it is essential to respect the few well-standardized recommendations and the dose-intensity, in a population with numerous comorbidities. We will first review quality assurance criteria for the general medical oncology organization and then focus on head and neck medical oncology. We will then describe administration specificities of head and neck treatments (chemoradiation, radiation plus cetuximab, postoperative chemoradiation, induction and palliative chemotherapy) as well as their follow-up. Lastly, we will offer some recommendations to improve quality assurance in head and neck medical oncology.

77 FR 1704 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-01-11

...: Center for Scientific Review Special Emphasis Panel; R15: Musculoskeletal Tissue Engineering, Oral, Bone and Skeletal Muscle Biology. Date: February 7-8, 2012. Time: 8 a.m. to 6 p.m. Agenda: To review and...

78 FR 52206 - Center For Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-08-22

...: Biophysics, Biochemistry and Chemistry. Date: September 18-19, 2013. Time: 8:00 a.m. to 3:00 p.m. Agenda: To..., Bethesda, MD 20892 (Virtual Meeting). Contact Person: John L Bowers, Ph.D., Scientific Review Officer..., Ph.D., Scientific Review Officer, Center for Scientific Review, National Institutes of Health, 6701...

78 FR 36789 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-06-19

.... Contact Person: Aruna K Behera, Ph.D., Scientific Review Officer, Center for Scientific Review, National...: Biochemistry & Macromolecular Biophysics. Date: July 15-17, 2013. Time: 8:00 a.m. to 12:00 p.m. Agenda: To..., Bethesda, MD 20892 (Virtual Meeting). Contact Person: James W Mack, Ph.D., Scientific Review Officer...

78 FR 27975 - Center for Scientific Review Notice of Closed Meetings

Science.gov (United States)

2013-05-13

...: Culture, Health and Wellbeing. Date: June 11, 2013. Time: 8:00 a.m. to 6:00 p.m. Agenda: To review and... . Name of Committee: Center for Scientific Review Special Emphasis Panel; Member conflict: Lung Diseases...

77 FR 53205 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-08-31

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Member Conflict... Interpersonal Processes Study Section. Date: October 4-5, 2012. Time: 8:00 a.m. to 6:00 p.m. Agenda: To review...

75 FR 6044 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-02-05

[email protected] . Name of Committee: Center for Scientific Review Special Emphasis Panel, Topics in...: Immunology. Date: March 8-9, 2010. Time: 8:30 a.m. to 6 p.m. Agenda: To review and evaluate grant...

The application of quality assurance

International Nuclear Information System (INIS)

Lovatt, G.B.

1988-01-01

The paper concerns the application of quality assurance to structures, systems and components for the design, construction and operation of nuclear power plant and fuel reprocessing plant. A description is given of:- the requirements for quality assurance, the establishment of quality assurance arrangements, quality assurance documents structure, and quality assurance manuals and programmes. Quality assurance procedures and auditing are also discussed. (U.K.)

77 FR 51033 - Center For Scientific Review; Notice of Closed Meeting

Science.gov (United States)

2012-08-23

...: Biochemistry. Date: August 27, 2012. Time: 10:45 a.m. to 12:15 p.m. Agenda: To review and evaluate grant... Conference Call). Contact Person: Nuria E. Assa-Munt, Ph.D., Scientific Review Officer, Center for Scientific...

78 FR 107 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-01-02

... Biochemistry of Membranes. Date: January 23, 2013. Time: 1:00 p.m. to 1:30 p.m. Agenda: To review and evaluate... 20036. Contact Person: Nitsa Rosenzweig, Ph.D., Scientific Review Officer, Center for Scientific Review... Santa Monica Hotel, 530 West Pico Boulevard, Santa Monica, CA 90405. Contact Person: David R. Jollie, Ph...

77 FR 77080 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-12-31

... Biochemistry of Membranes. Date: January 23, 2013. Time: 1:00 p.m. to 1:30 p.m. Agenda: To review and evaluate... 20036. Contact Person: Nitsa Rosenzweig, Ph.D., Scientific Review Officer, Center for Scientific Review... Santa Monica Hotel, 530 West Pico Boulevard, Santa Monica, CA 90405. Contact Person: David R. Jollie, Ph...

75 FR 80830 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-12-23

... Committee: Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrated Review Group; Pregnancy... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda...

Mental Health Services in School-Based Health Centers: Systematic Review

Science.gov (United States)

Bains, Ranbir Mangat; Diallo, Ana F.

2016-01-01

Mental health issues affect 20-25% of children and adolescents, of which few receive services. School-based health centers (SBHCs) provide access to mental health services to children and adolescents within their schools. A systematic review of literature was undertaken to review evidence on the effectiveness of delivery of mental health services…

Quality management and quality assurance

International Nuclear Information System (INIS)

Pieroni, N.

1991-01-01

The main common difficulties are presented found in the implementation of effective Quality Management and Quality Assurance Programmes, based on the recommendations of the IAEA International Nuclear Safety Advisory Group, the information collected by the IAEA experts participating in its meetings, and the results of the IAEA Operational Safety Review Team missions. The difficulties were identified in several areas. The most relevant root causes can be characterized as lack of understanding of quality principles and difficulty in implementation by the responsible management. The IAEA programme is described attempting to provide advice and support in the implementation of an effective quality programme through a number of activities including: preparation of practical guidelines, training programmes for management personnel, assistance in building up qualified manpower, and promoting the quest for excellence through the exchange of experience in the implementation of effective Quality Management and Quality Assurance Programmes in nuclear power plants with good performance records. (Z.S.)

76 FR 53688 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-08-29

... . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group, Clinical...- 1153, [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...

Financial assurances

International Nuclear Information System (INIS)

Paton, R.F.

1990-01-01

US Ecology is a full service waste management company. The company operates two of the nation's three existing low-level radioactive waste (LLRW) disposal facilities and has prepared and submitted license applications for two new LLRW disposal facilities in California and Nebraska. The issue of financial assurances is an important aspect of site development and operation. Proper financial assurances help to insure that uninterrupted operation, closure and monitoring of a facility will be maintained throughout the project's life. Unfortunately, this aspect of licensing is not like others where you can gauge acceptance by examining approved computer codes, site performance standards or applying specific technical formulas. There is not a standard financial assurance plan. Each site should develop its requirements based upon the conditions of the site, type of design, existing state or federal controls, and realistic assessments of future financial needs. Financial assurances at U.S. Ecology's existing sites in Richland, Washington, and Beatty, Nevada, have been in place for several years and are accomplished in a variety of ways by the use of corporate guarantees, corporate capital funds, third party liability insurance, and post closure/long-term care funds. In addressing financial assurances, one can divide the issue into three areas: Site development/operations, third party damages, and long-term care/cleanup

77 FR 63842 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-10-17

... applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD....m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M... Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person...

76 FR 66075 - Center for Scientific Review Notice of Closed Meetings

Science.gov (United States)

2011-10-25

... commercial property such as patentable material, and personal information concerning individuals associated...-1165, [email protected] . Name of Committee: AIDS and Related Research Integrated Review Group HIV...: Center for Scientific Review Special Emphasis Panel; Cancer Biology and Signaling. Date: November 30...

78 FR 26376 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-05-06

...; Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section. Date: May 30-31, 2013. Time: 8... of Committee: Integrative, Functional and Cognitive Neuroscience Integrated Review Group..., [email protected] . Name of Committee: Center for Scientific Review Special Emphasis Panel; Vision...

78 FR 29144 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-05-17

... Committee: Healthcare Delivery and Methodologies Integrated Review Group Biostatistical Methods and Research... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review..., 4300 Military Road NW., Washington, DC 20015. Contact Person: Katherine M Malinda, Ph.D., Scientific...

75 FR 52764 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-08-27

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Member Conflict..., Bethesda, MD 20892. (301) 435- 0684. [email protected] . Name of Committee: Integrative, Functional and....gov . Name of Committee: Integrative, Functional and Cognitive Neuroscience Integrated Review Group...

78 FR 26378 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-05-06

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... 5184, MSC 7844, Bethesda, MD 20892 301-435- 1242, [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group; Clinical, Integrative and Molecular...

75 FR 78716 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-12-16

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... 20892. (301) 451-1323. [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group. Hepatobiliary Pathophysiology Study Section. Date: January 31-February 1...

77 FR 52338 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-08-29

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review..., Bethesda, MD 20892, (301) 408-9512, [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group; Clinical, Integrative and Molecular Gastroenterology Study...

78 FR 55268 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-09-10

...-2409, [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Review Group; Atherosclerosis and Inflammation of the Cardiovascular System Study Section. Date: October...

Centers for manufacturing technology: Industrial Advisory Committee Review

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-10-01

An advisory committee, composed of senior managers form industrial- sector companies and major manufacturing trade associations and representatives from appropriate educational institutions, meets semi-annually to review and advise the Oak Ridge Centers for Manufacturing Technology (ORCMT) on its economic security program. Individual papers have been indexed separately for the database.

Operating the plant, quality assurance, and the job of the operating staff, Volume Twelve

International Nuclear Information System (INIS)

Anon.

1986-01-01

Subject matter includes operating the plant (the role of the operator, the control room, plant technical specifications, plant operating procedures, initial startup program, BWR/PWR plant startup, BWR/PWR steady state power operation, BWR/PWR transient operation, emergency operation), quality assurance (what is quality, what is quality control, quality assurance includes quality control, government regulation and quality assurance, administrative controls for nuclear power plants, the necessity of reviews and audits, practical quality assurance), and the job of the operating staff (the plant operating staff, plant safety, first aid and resuscitation, general plant hazards, personnel protective equipment, handling chemicals, handling compressed gas, equipment repair and maintenance, communicating with others

77 FR 33476 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-06-06

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Hematology. Date: June 25-26, 2012. Time: 10:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant..., Drug Use, Food Insecurity. Date: June 26, 2012. Time: 1:00 p.m. to 5:00 p.m. Agenda: To review and...

78 FR 12071 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-02-21

...: Immunology. Date: March 13, 2013. Time: 8:00 a.m. to 10:00 p.m. Agenda: To review and evaluate [email protected] . Name of Committee: Center for Scientific Review Special Emphasis Panel; Special Topics: Topics in Bacterial Pathogenesis. Date: March 14-15, 2013. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review...

Quality assurance in the Antares laser fusion construction project

International Nuclear Information System (INIS)

Reichelt, W.H.

1984-01-01

The Antares CO 2 laser facility came on line in November 1983 as an experimental physics facility; it is the world's largest CO 2 laser fusion system. Antares is a major component of the Department of Energy's Inertial Confinement Fusion Program. Antares is a one-of-a-kind laser system that is used in an experimental environment. Given limited project funds and tight schedules, the quality assurance program was tailored to achieve project goals without imposing oppressive constraints. The discussion will review the Antares quality assurance program and the utility of various portions to completion of the project

SU-E-T-148: Benchmarks and Pre-Treatment Reviews: A Study of Quality Assurance Effectiveness

International Nuclear Information System (INIS)

Lowenstein, J; Nguyen, H; Roll, J; Walsh, A; Tailor, A; Followill, D

2015-01-01

Purpose: To determine the impact benchmarks and pre-treatment reviews have on improving the quality of submitted clinical trial data. Methods: Benchmarks are used to evaluate a site’s ability to develop a treatment that meets a specific protocol’s treatment guidelines prior to placing their first patient on the protocol. A pre-treatment review is an actual patient placed on the protocol in which the dosimetry and contour volumes are evaluated to be per protocol guidelines prior to allowing the beginning of the treatment. A key component of these QA mechanisms is that sites are provided timely feedback to educate them on how to plan per the protocol and prevent protocol deviations on patients accrued to a protocol. For both benchmarks and pre-treatment reviews a dose volume analysis (DVA) was performed using MIM softwareTM. For pre-treatment reviews a volume contour evaluation was also performed. Results: IROC Houston performed a QA effectiveness analysis of a protocol which required both benchmarks and pre-treatment reviews. In 70 percent of the patient cases submitted, the benchmark played an effective role in assuring that the pre-treatment review of the cases met protocol requirements. The 35 percent of sites failing the benchmark subsequently modified there planning technique to pass the benchmark before being allowed to submit a patient for pre-treatment review. However, in 30 percent of the submitted cases the pre-treatment review failed where the majority (71 percent) failed the DVA. 20 percent of sites submitting patients failed to correct their dose volume discrepancies indicated by the benchmark case. Conclusion: Benchmark cases and pre-treatment reviews can be an effective QA tool to educate sites on protocol guidelines and to minimize deviations. Without the benchmark cases it is possible that 65 percent of the cases undergoing a pre-treatment review would have failed to meet the protocols requirements.Support: U24-CA-180803

Evaluation of High Density Air Traffic Operations with Automation for Separation Assurance, Weather Avoidance and Schedule Conformance

Science.gov (United States)

Prevot, Thomas; Mercer, Joey S.; Martin, Lynne Hazel; Homola, Jeffrey R.; Cabrall, Christopher D.; Brasil, Connie L.

2011-01-01

In this paper we discuss the development and evaluation of our prototype technologies and procedures for far-term air traffic control operations with automation for separation assurance, weather avoidance and schedule conformance. Controller-in-the-loop simulations in the Airspace Operations Laboratory at the NASA Ames Research Center in 2010 have shown very promising results. We found the operations to provide high airspace throughput, excellent efficiency and schedule conformance. The simulation also highlighted areas for improvements: Short-term conflict situations sometimes resulted in separation violations, particularly for transitioning aircraft in complex traffic flows. The combination of heavy metering and growing weather resulted in an increased number of aircraft penetrating convective weather cells. To address these shortcomings technologies and procedures have been improved and the operations are being re-evaluated with the same scenarios. In this paper we will first describe the concept and technologies for automating separation assurance, weather avoidance, and schedule conformance. Second, the results from the 2010 simulation will be reviewed. We report human-systems integration aspects, safety and efficiency results as well as airspace throughput, workload, and operational acceptability. Next, improvements will be discussed that were made to address identified shortcomings. We conclude that, with further refinements, air traffic control operations with ground-based automated separation assurance can routinely provide currently unachievable levels of traffic throughput in the en route airspace.

75 FR 1399 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-01-11

... Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person... Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Syed M... a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M...

76 FR 63314 - Center for Scientific Review Notice of Closed Meetings

Science.gov (United States)

2011-10-12

... for Scientific Review Special Emphasis Panel, PAR-10-235: Climate Change and Health. Date: November 8... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892...

78 FR 1864 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-01-09

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrated Review Group, Pregnancy and Neonatology Study Section. Date: February 5-6, 2013. Time: 8:00 a.m...

77 FR 3478 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-01-24

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... evaluate grant applications. Place: Sheraton Delfina Santa Monica Hotel, 530 West Pico Boulevard, Santa... Review, National Institutes of Health, 6701 Rockledge Drive, Room 4132, MSC 7802, Bethesda, MD 20892...

75 FR 54893 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-09-09

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Selected Topics... . Name of Committee: Immunology Integrated Review Group, Innate Immunity and Inflammation Study Section... 5132, MSC 7843, Bethesda, MD 20892. 301-594-6830. [email protected] . Name of Committee: Immunology...

75 FR 1795 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-01-13

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... 20892. (301) 435-2477. [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group, Cellular and Molecular Biology of the Kidney Study Section. Date...

77 FR 54580 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-09-05

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... 3108, MSC 7808, Bethesda, MD 20892, (301) 435- 3562, [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group, Kidney Molecular Biology and Genitourinary Organ...

77 FR 2738 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-01-19

... Committee: Digestive, Kidney and Urological Systems Integrated Review Group; Hepatobiliary Pathophysiology... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5...

75 FR 54156 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-09-03

... Committee: Digestive, Kidney and Urological Systems Integrated Review Group, Gastrointestinal Mucosal... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5...

77 FR 1699 - Center for Scientific Review: Notice of Closed Meetings

Science.gov (United States)

2012-01-11

... Committee: Digestive, Kidney and Urological Systems Integrated Review Group; Gastrointestinal Mucosal... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review: Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5...

Nova laser assurance-management system

International Nuclear Information System (INIS)

Levy, A.J.

1983-01-01

In a well managed project, Quality Assurance is an integral part of the management activities performed on a daily basis. Management assures successful performance within budget and on schedule by using all the good business, scientific, engineering, quality assurance, and safety practices available. Quality assurance and safety practices employed on Nova are put in perspective by integrating them into the overall function of good project management. The Nova assurance management system was developed using the quality assurance (QA) approach first implemented at LLNL in early 1978. The LLNL QA program is described as an introduction to the Nova assurance management system. The Nova system is described pictorially through the Nova configuration, subsystems and major components, interjecting the QA techniques which are being pragmatically used to assure the successful completion of the project

Laboratory quality assurance

International Nuclear Information System (INIS)

Delvin, W.L.

1977-01-01

The elements (principles) of quality assurance can be applied to the operation of the analytical chemistry laboratory to provide an effective tool for indicating the competence of the laboratory and for helping to upgrade competence if necessary. When used, those elements establish the planned and systematic actions necessary to provide adequate confidence in each analytical result reported by the laboratory (the definition of laboratory quality assurance). The elements, as used at the Hanford Engineering Development Laboratory (HEDL), are discussed and they are qualification of analysts, written methods, sample receiving and storage, quality control, audit, and documentation. To establish a laboratory quality assurance program, a laboratory QA program plan is prepared to specify how the elements are to be implemented into laboratory operation. Benefits that can be obtained from using laboratory quality assurance are given. Experience at HEDL has shown that laboratory quality assurance is not a burden, but it is a useful and valuable tool for the analytical chemistry laboratory

Quality assurance in radiation therapy: clinical aspects

International Nuclear Information System (INIS)

Souhami, L.

1984-01-01

A survey was conducted in Latin America to evaluate the clinical aspects of quality assurance in radiotherapy. A questionnaire was prepared and sent to 46 institutions. Twenty-seven centers (58.5%), from nine countries, answered the questionnaire. The study was divided into three topics: a) patient-related statistics; b) staffing and education; and c) equipment and facilities. Radiotherapy training programs are available in only 37% of the centers studied. A large number of megavoltage units are old, operating at a shorter than optimum distance with sources of very low activity. The number of high energy linear accelerators is unsatisfactory. Problems in treatment planning facilities were also identified. Regionalization of radiation therapy services is recommended as a possible way to improve quality at a reasonable cost

Review of Regulatory Quality Assurance Requirements for the Operation of Nuclear R and D Facilities

International Nuclear Information System (INIS)

Kwon, Hyuk Il; Lim, Nam Jin

2005-01-01

Korea Atomic Energy Research Institute (KAERI) has many R and D facilities in operation, including HANARO research reactor, radioactive waste treatment facility (RWTF), post-irradiation examination facility (PIEF) and irradiated material test facility (IMEF). Recently, nation-wide interest is focused on the safety and security of major industrial facilities. Safe operation of nuclear facilities is imperative because of the consequence of public disaster by radiological release/ contamination, in case of an accident. Recently, Ministry of Science and Technology (MOST) of the Korean government announced amendments of Atomic Energy laws to enforce requirements of the physical protection and radiological emergency. In this paper, the context of amended Atomic Energy laws were reviewed to confirm quality assurance measures and identify additional QA activities, if any, that is required by the amendment

Bibliometric analysis of poison center-related research published in peer-review journals.

Science.gov (United States)

Forrester, M B

2016-07-01

Poison centers advance knowledge in the field of toxicology through publication in peer-review journals. This investigation describes the pattern of poison center-related publications. Cases were poison center-related research published in peer-review journals during 1995-2014. These were identified through searching the PubMed database, reviewing the tables of contents of selected toxicology journals, and reviewing abstracts of various national and international meetings. The following variables for each publication were identified: year of publication, journal, type of publication (meeting abstract vs. other, i.e. full article or letter to the editor), and the country(ies) of the poison center(s) included in the research. Of the 3147 total publications, 62.1% were meeting abstracts. There were 263 publications in 1995-1999, 536 in 2000-2004, 999 in 2005-2009, and 1349 in 2010-2014. The publications were in 234 different journals. The journals in which the highest number of research was published were Clinical Toxicology (69.7%), Journal of Medical Toxicology (2.2%), and Veterinary and Human Toxicology (2.1%). The research was reported from 62 different countries. The countries with the highest number of publications were the United States (67.9%), United Kingdom (6.5%), Germany (3.9%), France (2.5%), and Italy (2.4%). The number of publications increased greatly over the 20 years. Although the publications were in a large number of journals, a high proportion of the publications were in one journal. While the research came from a large number of countries, the preponderance came from the United States. © The Author(s) 2015.

Performance assurance for IT systems

CERN Document Server

King, Brian

2004-01-01

INDIVIDUAL AREAS OF INTERESTPreparing for the ChallengeAbstractIntroductionIn the BeginningThe Need to Address New ApplicationsDefinition of PerformanceThe Required SkillsPerformance Assurance Within a Project LifecycleSummaryCaveat Emptor (Let the Buyer Beware)AbstractSoftware Product LifecycleHardware Product LifecycleMarketingTechnical Reviews of ProductsLies, Damned Lies and BenchmarksAbstractIntroductionIndustry BenchmarksVendor BenchmarksIndependent BenchmarkingIn-House Benchmarking""Tricks of the Trade""Using Benchmarks Non-Functional Requirements and SolutionsAbstractIntroductionThe Pr

Materiality and external assurance in corporate sustainability reporting: An exploratory study of UK house builders

OpenAIRE

Jones, Peter; Comfort, Daphne; Hillier, David

2015-01-01

This paper provides a preliminary examination of the extent to which the UK’s leading house builders are embracing the concept of materiality and commissioning independent external assurance as part of their sustainability reporting processes and to offer some wider reflections on materiality and external assurance in sustainability reporting.\\ud \\ud The paper begins with a review of the characteristics of materiality and external assurance and a brief outline of house building in the UK and ...

75 FR 64735 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-10-20

... commercial property such as patentable material, and personal information concerning individuals associated...: Center for Scientific Review Special Emphasis Panel; Small Business: Experimental Cancer Therapeutics... Conflict: HIV/AIDS. Date: November 16, 2010. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant...

77 FR 27468 - Center for Scientific Review, Notice of Closed Meetings

Science.gov (United States)

2012-05-10

..., (Virtual Meeting). Contact Person: Edwin C Clayton, Ph.D., Scientific Review Officer, Center for Scientific...-408-9041, [email protected] . Name of Committee: Biological Chemistry and Macromolecular Biophysics Integrated Review Group; Synthetic and Biological Chemistry B Study Section. Date: May 30-31, 2012. Time: 8...

78 FR 26644 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-05-07

...: Digestive, Kidney and Urological Systems Integrated Review Group; Xenobiotic and Nutrient Disposition and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5...

78 FR 28599 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-05-15

... Committee: Digestive, Kidney and Urological Systems Integrated Review Group, Kidney Molecular Biology and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5...

78 FR 54258 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-09-03

... Committee: Digestive, Kidney and Urological Systems Integrated Review Group; Clinical, Integrative and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5...

77 FR 511 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-01-05

...: Digestive, Kidney and Urological Systems Integrated Review Group, Clinical, Integrative and Molecular... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5...

'Screening audit' as a quality assurance tool in good clinical practice compliant research environments.

Science.gov (United States)

Park, Sinyoung; Nam, Chung Mo; Park, Sejung; Noh, Yang Hee; Ahn, Cho Rong; Yu, Wan Sun; Kim, Bo Kyung; Kim, Seung Min; Kim, Jin Seok; Rha, Sun Young

2018-04-25

With the growing amount of clinical research, regulations and research ethics are becoming more stringent. This trend introduces a need for quality assurance measures for ensuring adherence to research ethics and human research protection beyond Institutional Review Board approval. Audits, one of the most effective tools for assessing quality assurance, are measures used to evaluate Good Clinical Practice (GCP) and protocol compliance in clinical research. However, they are laborious, time consuming, and require expertise. Therefore, we developed a simple auditing process (a screening audit) and evaluated its feasibility and effectiveness. The screening audit was developed using a routine audit checklist based on the Severance Hospital's Human Research Protection Program policies and procedures. The measure includes 20 questions, and results are summarized in five categories of audit findings. We analyzed 462 studies that were reviewed by the Severance Hospital Human Research Protection Center between 2013 and 2017. We retrospectively analyzed research characteristics, reply rate, audit findings, associated factors and post-screening audit compliance, etc. RESULTS: Investigator reply rates gradually increased, except for the first year (73% → 26% → 53% → 49% → 55%). The studies were graded as "critical," "major," "minor," and "not a finding" (11.9, 39.0, 42.9, and 6.3%, respectively), based on findings and number of deficiencies. The auditors' decisions showed fair agreement with weighted kappa values of 0.316, 0.339, and 0.373. Low-risk level studies, single center studies, and non-phase clinical research showed more prevalent frequencies of being "major" or "critical" (p = 0.002, audit grade (p audit results of post-screening audit compliance checks in "non-responding" and "critical" studies upon applying the screening audit. Our screening audit is a simple and effective way to assess overall GCP compliance by institutions and to

Quality assurance for geologic investigations

International Nuclear Information System (INIS)

Delvin, W.L.; Gustafson, L.D.

1983-01-01

A quality assurance handbook was written to provide guidance in the application of quality assurance to geologic work activities associated with the National Waste Terminal Storage (NWTS) Program. It is intended to help geoscientists and NWTS program managers in applying quality assurance to their work activities and projects by showing how technical and quality assurance practices are integrated to provide control within those activities and projects. The use of the guidance found in this handbook should help provide consistency in the interpretation of quality assurance requirements across the various geologic activities wihtin the NWTS Program. This handbook also can assist quality assurance personnel in understanding the relationships between technical and quality assurance practices. This paper describes the handbook

Quality assurance for geologic investigations

International Nuclear Information System (INIS)

Delvin, W.L.; Gustafson, L.D.

1983-01-01

A quality assurance handbook was written to provide guidance in the application of quality assurance to geologic work activities associated with the National Waste Terminal Storage (NWTS) Program. It is intended to help geoscientists and NWTS program managers in applying quality assurance to their work activitie and projects by showing how technical and quality assurance practices are integrated to provide control within those activities and projects. The use of the guidance found in this handbook should help provide consistency in the interpretation of quality assurance requirements across the various geologic activities within the NWTS Program. This handbook also can assist quality assurance personnel in understanding the relationships between technical and quality assurance practices. This paper describes the handbook

Developing and Implementing a Quality Assurance Strategy for Electroconvulsive Therapy.

Science.gov (United States)

Hollingsworth, Jessa; Baliko, Beverly; McKinney, Selina; Rosenquist, Peter

2018-04-17

The literature provides scant guidance in effective quality assurance strategies concerning the use of electroconvulsive therapy (ECT) for the treatment of psychiatric conditions. Numerous guidelines are published that provide guidance in the delivery of care; however, little has been done to determine how a program or facility might ensure compliance to best practice for safety, tolerability, and efficacy in performing ECT. The objective of this project was to create a quality assurance strategy specific to ECT. Determining standards for quality care and clarifying facility policy were key outcomes in establishing an effective quality assurance strategy. An audit tool was developed utilizing quality criteria derived from a systematic review of ECT practice guidelines, peer review, and facility policy. All ECT procedures occurring over a 2-month period of May to June 2017 were retrospectively audited and compared against target compliance rates set for the facility's ECT program. Facility policy was adapted to reflect quality standards, and audit findings were used to inform possible practice change initiatives, were used to create benchmarks for continuous quality monitoring, and were integrated into regular hospital quality meetings. Clarification on standards of care and the use of clinical auditing in ECT was an effective starting point in the development of a quality assurance strategy. Audit findings were successfully integrated into the hospital's overall quality program, and recognition of practice compliance informed areas for future quality development and policy revision in this small community-based hospital in the southeastern United States. This project sets the foundation for a quality assurance strategy that can be used to help monitor procedural safety and guide future improvement efforts in delivering ECT. Although it is just the first step in creating meaningful quality improvement, setting clear standards and identifying areas of greatest

Quality Assurance in Open, Distance and Online Education in ...

African Journals Online (AJOL)

Quality assurance in the education sector is the systematic review of educational programmes to ensure that acceptable standards of education, scholarship and infrastructure are being maintained. The current vision and strategic direction of many organisations has raised the importance of using technology to create ...

The Rockford School of Medicine Undergraduate Quality Assurance Program

Science.gov (United States)

Barr, Daniel; And Others

1976-01-01

An undergraduate program of ambulatory care quality assurance is described which has been operational at the Rockford School of Medicine for three years. Focus is on involving students in peer review and related audit activities. Results of preliminary evaluation are reported and generalizations offered. (JT)

77 FR 61770 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-10-11

... commercial property such as patentable material, and personal information concerning individuals associated... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Cancer...: Multidisciplinary Studies of HIV/AIDS and Aging. Date: November 9, 2012. Time: 10 a.m. to 6 p.m. Agenda: To review...

75 FR 51081 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-08-18

...: Pregnancy, Neonatology, and Nutrition. Date: September 7-8, 2010. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...

75 FR 60763 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-10-01

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78 FR 59040 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-09-25

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M Street, NW., Washington, DC..., National Institutes of Health, 6701 Rockledge Drive, Room 5218, MSC 7852, Bethesda, MD 20892, 301-435- 1775...

76 FR 53479 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-08-26

...: Center for Scientific Review Special Emphasis Panel; Member Conflict: Cancer Biology and Genetics. Date....gov . Name of Committee: Cell Biology Integrated Review Group; Development--2 Study Section. Date... Emphasis Panel; Cellular and Molecular Neuroscience. Date: September 30, 2011. Time: 1 p.m. to 4 p.m...

78 FR 3905 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-01-17

... Special Emphasis Panel; Member Conflict: Cell Biology. Date: February 15, 2013. Time: 11:00 a.m. to 2:00 p...: Oncology 1--Basic Translational Integrated Review Group; Cancer Molecular Pathobiology Study Section. Date... of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Basic Biology of...

78 FR 6125 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-01-29

..., [email protected] . Name of Committee: Digestive, Kidney and Urological Systems Integrated Review Group... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5...

76 FR 24036 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-04-29

...: Digestive, Kidney and Urological Systems Integrated Review Group, Pathobiology of Kidney Disease Study... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Group, Somatosensory and Chemosensory Systems Study Section. Datea: June 7-8, 2011. Time: 8 a.m. to 5 p...

Local audit of diagnostic surgical pathology as a tool for quality assurance.

Science.gov (United States)

Malami, Sani Abubakar; Iliyasu, Yawale

2008-01-01

Internal audit has been rarely done for quality assurance of histology laboratories in Nigeria. We reviewed the steps involved in the production of reports with a view to assessing the performance of the histopathology laboratory of Aminu Kano Teaching Hospital, Nigeria. A randomly selected 2 per cent sample of the total histology workload of the center for the year ending December 2005 amounting to 2877 cases was systematically reviewed. Analysis of the accumulated data showed a concordance rate of 94.8% between the original and review histological diagnoses, comparable to other published studies. Significant defects were observed to be due to missing demographic information on request forms (22.8%), poor technical quality of slide sections (18.4%) and typographical errors by typists (12.3%) In a minority of cases microscopic description was inadequate or inappropriate (7.0%) and some were inaccurate (2.7%). The turnaround time ranged from 2 to 16 days (mean 6.2 days) with results of 75.8 per cent of the specimens completed within 7 days. From the study we have shown that local audit is feasible in Nigerian laboratories and is an excellent method for detecting errors and improving performance in Surgical Pathology to optimize the scarce resources available to patient care in our country.

USEPA QUALITY ASSURANCE AUDITOR IS SCHEDULED FOR A VISIT. WHAT CAN I EXPECT?

Science.gov (United States)

Environmental studies involving data collection activities conducted by or for the United States Environmental Protection Agency (USEPA) are required to undergo a review of their data collection activities. his review is usually in the form of an independent quality assurance (QA...

76 FR 14036 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-03-15

..., [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific... 7852, Bethesda, MD 20892, (301) 435-1166, [email protected]csr.nih.gov . Name of Committee: Center for...

Quality assurance handbook for measurement laboratories

International Nuclear Information System (INIS)

Delvin, W.L.

1984-10-01

This handbook provides guidance in the application of quality assurance to measurement activities. It is intended to help those persons making measurements in applying quality assurance to their work activities by showing how laboratory practices and quality assurance requirements are integrated to provide control within those activities. The use of the guidance found in this handbook should help provide consistency in the interpretation of quality assurance requirements across all types of measurement laboratories. This handbook also can assist quality assurance personnel in understanding the relationships between laboratory practices and quality assurance requirements. The handbook is composed of three chapters and several appendices. Basic guidance is provided by the three chapters. In Chapter 1, the role of quality assurance in obtaining quality data and the importance of such data are discussed. Chapter 2 presents the elements of laboratory quality assurance in terms of practices that can be used in controlling work activities to assure the acquisition of quality data. Chapter 3 discusses the implementation of laboratory quality assurance. The appendices provide supplemental information to give the users a better understanding of the following: what is quality assurance; why quality assurance is required; where quality assurance requirements come from; how those requirements are interpreted for application to laboratory operations; how the elements of laboratory quality assurance relate to various laboratory activities; and how a quality assurance program can be developed

Quality assurance of metabolomics.

Science.gov (United States)

Bouhifd, Mounir; Beger, Richard; Flynn, Thomas; Guo, Lining; Harris, Georgina; Hogberg, Helena; Kaddurah-Daouk, Rima; Kamp, Hennicke; Kleensang, Andre; Maertens, Alexandra; Odwin-DaCosta, Shelly; Pamies, David; Robertson, Donald; Smirnova, Lena; Sun, Jinchun; Zhao, Liang; Hartung, Thomas

2015-01-01

Metabolomics promises a holistic phenotypic characterization of biological responses to toxicants. This technology is based on advanced chemical analytical tools with reasonable throughput, including mass-spectroscopy and NMR. Quality assurance, however - from experimental design, sample preparation, metabolite identification, to bioinformatics data-mining - is urgently needed to assure both quality of metabolomics data and reproducibility of biological models. In contrast to microarray-based transcriptomics, where consensus on quality assurance and reporting standards has been fostered over the last two decades, quality assurance of metabolomics is only now emerging. Regulatory use in safety sciences, and even proper scientific use of these technologies, demand quality assurance. In an effort to promote this discussion, an expert workshop discussed the quality assurance needs of metabolomics. The goals for this workshop were 1) to consider the challenges associated with metabolomics as an emerging science, with an emphasis on its application in toxicology and 2) to identify the key issues to be addressed in order to establish and implement quality assurance procedures in metabolomics-based toxicology. Consensus has still to be achieved regarding best practices to make sure sound, useful, and relevant information is derived from these new tools.

Quality assurance

International Nuclear Information System (INIS)

Cante; Feger; Genevray; Hennion; Moneyron; Monneyron; Normand; Rastoin; Silberstein; Vaujour.

1976-01-01

The general principles of quality assurance and their applications within the French industrial and commercial regulations are presented. The conditions for the practical application of quality assurance to the different stages of the life of a nuclear power station (design, development, operation) are considered and a special mention is made of nuclear fuels and liquid sodium cooled reactors [fr

The case of sustainability assurance: constructing a new assurance service

NARCIS (Netherlands)

O'Dwyer, B.

2011-01-01

This paper presents an in-depth longitudinal case study examining the processes through which practitioners in two Big 4 professional services firms have attempted to construct sustainability assurance (independent assurance on sustainability reports). Power’s (1996, 1997, 1999, 2003) theorization

78 FR 61377 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-10-03

... commercial property such as patentable material, and personal information concerning individuals associated...: Center for Scientific Review Special Emphasis Panel;PAR-13-007: Early-Stage Pharmacological Validation of... Conflict: Cognition and Perception. Date: October 31, 2013. Time: 12:30 p.m. to 1:30 p.m. Agenda: To review...

78 FR 66018 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-11-04

... Panel, Accelerator Mass Spectrometry Facility. Date: December 2-3, 2013. Time: 8:00 a.m. to 6:00 p.m... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... personal privacy. Name of Committee: AIDS and Related Research Integrated Review Group, AIDS-associated...

75 FR 55592 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-09-13

... Conference Call). Contact Person: Tomas Drgon, PhD, Scientific Review Officer, HDM IRG, Center for Scientific..., [email protected] . Name of Committee: Cardiovascular and Respiratory Sciences Integrated Review Group...: Risk Prevention and Health Behavior. Date: October 21-22, 2010. Time: 8 a.m. to 5 p.m. Agenda: To...

78 FR 35943 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-06-14

... Panel; Overflow: Molecular Innate and Adaptive Immunology. Date: July 9, 2013. Time: 11:00 a.m. to 1:00....gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Topics in Bacterial....nih.gov . Name of Committee: AIDS and Related Research Integrated Review Group; AIDS Immunology and...

75 FR 7486 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-02-19

... Business: Cell Biology and Molecular Imaging. Date: March 11, 2010. Time: 8 a.m. to 6 p.m. Agenda: To... Scientific Review Special Emphasis Panel, Small Business: Developmental Biology and Aging. Date: March 2-3... . Name of Committee: Center for Scientific Review Special Emphasis Panel, Member Conflict: Cancer...

Nuclear power: energy security and supply assurances

International Nuclear Information System (INIS)

Rogner, H.H.; McDonald, A.

2008-01-01

Expectations are high for nuclear power. This paper first summarizes recent global and regional projections for the medium-term, including the 2007 updates of IAEA projections plus International Energy Agency and World Energy Technology Outlook projections to 2030 and 2050. One driving force for nuclear power is concern about energy supply security. Two potential obstacles are concerns about increased nuclear weapon proliferation risks, and concerns by some countries about potential politically motivated nuclear fuel supply interruptions. Concerning supply security, the paper reviews different definitions, strategies and costs. Supply security is not free; nor does nuclear power categorically increase energy supply security in all situations. Concerning proliferation and nuclear fuel cut-off risks, the IAEA and others are exploring possible 'assurance of supply' mechanisms with 2 motivations. First, the possibility of a political fuel supply interruption is a non-market disincentive discouraging investment in nuclear power. Fuel supply assurance mechanisms could reduce this disincentive. Second, the risk of interruption creates an incentive for a country to insure against that risk by developing a national enrichment capability. Assurance mechanisms could reduce this incentive, thereby reducing the possible spread of new national enrichment capabilities and any associated weapon proliferation risks. (orig.)

Risk management and lessons learned solutions for satellite product assurance

Science.gov (United States)

Larrère, Jean-Luc

2004-08-01

The historic trend of the space industry towards lower cost programmes and more generally a better economic efficiency raises a difficult question to the quality assurance community: how to achieve the same—or better—mission success rate while drastically reducing the cost of programmes, hence the cost and level of quality assurance activities. EADS Astrium Earth Observation and Science (France) Business Unit have experimented Risk Management and Lessons Learned on their satellite programmes to achieve this goal. Risk analysis and management are deployed from the programme proposal phase through the development and operations phases. Results of the analysis and the corresponding risk mitigation actions are used to tailor the product assurance programme and activities. Lessons learned have been deployed as a systematic process to collect positive and negative experience from past and on-going programmes and feed them into new programmes. Monitoring and justification of their implementation in programmes is done under supervision from the BU quality assurance function. Control of the system is ensured by the company internal review system. Deployment of these methods has shown that the quality assurance function becomes more integrated in the programme team and development process and that its tasks gain focus and efficiency while minimising the risks associated with new space programmes.

75 FR 48977 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-08-12

.... [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific..., Room 5181, MSC 7844, Bethesda, MD 20892. 301-435- 1033. [email protected]csr.nih.gov . Name of Committee: Center...

Study on quality assurance for high-level radioactive waste disposal project

International Nuclear Information System (INIS)

Takada, Susumu

2005-01-01

The U.S. Department of Energy (DOE) has developed comparatively detailed quality assurance requirements for the high-level radioactive waste disposal systems. Quality assurance is recognized as a key issue for confidence building and smooth implementation of the HLW program in Japan, and Japan is at an initial phase of repository development. Then the quality assurance requirements at site research and site selection, site characterization, and site suitability analysis used in the Yucca Mountain project were examined in detail and comprehensive descriptions were developed using flow charts. Additionally, the applicability to the Japan high-level radioactive waste disposal project was studied. The examination and study were performed for the following QA requirements: The requirements that have the relative importance at site research and site selection, site characterization, and site suitability analysis (such as planning and performing scientific investigations, sample control, data control, model development and use, technical report review, software control, and control of the electric management of data). The requirements that have the relative importance at the whole repository phases (such as quality assurance program, document control, and control of quality assurance records). (author)

78 FR 9064 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-02-07

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Panel; PAR Panel: Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems. Date: March 4-5, 2013. Time: 10:00 a.m. to 6:00 p.m. Agenda: To review and evaluate grant...

Epidemiology, surgical management and early postoperative outcome in a cohort of gastric cancer patients of a tertiary referral center in relation to multi-center quality assurance studies.

Science.gov (United States)

Garlipp, Benjamin; Schwalenberg, Jens; Adolf, Daniela; Lippert, Hans; Meyer, Frank

2011-03-01

The aim of the study was to analyze epidemiologic parameters, treatment-related data and prognostic factors in the management of gastric cancer patients of a university surgical center under conditions of routine clinical care before the onset of the era of multimodal therapies. By analyzing our data in relation with multi-center quality assurance trials [German Gastric Cancer Study - GGCS (1992) and East German Gastric Cancer Study - EGGCS (2004)] we aimed at providing an instrument of internal quality control at our institution as well as a base for comparison with future analyses taking into account the implementation of evolving (multimodal) therapies and their influence on treatment results. Retrospective analysis of prospectively gathered data of gastric cancer patients treated at a single institution during a defined 10-year time period with multivariate analysis of risk factors for early postoperative outcome. From 04/01/1993 through 03/31/2003, a total of 328 gastric cancer patients were treated. In comparison with the EGGCS cohort there was a larger proportion of patients with locally advanced and proximally located tumors. 272 patients (82.9%) underwent surgery with curative intent; in 88.4% of these an R0 resection was achieved (EGGCS/GGCS: 82.5%/71.5%). 68.2% of patients underwent preoperative endoluminal ultrasound (EUS) (EGGCS: 27.4%); the proportion of patients undergoing EUS increased over the study period. Diagnostic accuracy of EUS for T stage was 50.6% (EGGCS: 42.6%). 77.2% of operated patients with curative intent underwent gastrectomy (EGGCS/GGCS: 79.8%/71.1%). Anastomotic leaks at the esophagojejunostomy occurred slightly more frequently (8.8%) than in the EGGCS (5.9%) and GGCS (7.2%); however, postoperative morbidity (36.1%) and early postoperative mortality (5.3%) were not increased compared to the multi-center quality assurance study results (EGGCS morbidity, 45%); EGGCS/GGCS mortality, 8%/8.9%). D2 lymphadenectomy was performed in 72

Quality assurance for gamma knives

International Nuclear Information System (INIS)

Jones, E.D.; Banks, W.W.; Fischer, L.E.

1995-09-01

This report describes and summarizes the results of a quality assurance (QA) study of the Gamma Knife, a nuclear medical device used for the gamma irradiation of intracranial lesions. Focus was on the physical aspects of QA and did not address issues that are essentially medical, such as patient selection or prescription of dose. A risk-based QA assessment approach was used. Sample programs for quality control and assurance are included. The use of the Gamma Knife was found to conform to existing standards and guidelines concerning radiation safety and quality control of external beam therapies (shielding, safety reviews, radiation surveys, interlock systems, exposure monitoring, good medical physics practices, etc.) and to be compliant with NRC teletherapy regulations. There are, however, current practices for the Gamma Knife not covered by existing, formalized regulations, standards, or guidelines. These practices have been adopted by Gamma Knife users and continue to be developed with further experience. Some of these have appeared in publications or presentations and are slowly finding their way into recommendations of professional organizations

Quality assurance for gamma knives

Energy Technology Data Exchange (ETDEWEB)

Jones, E.D.; Banks, W.W.; Fischer, L.E. [Lawrence Livermore National Lab., CA (United States)

1995-09-01

This report describes and summarizes the results of a quality assurance (QA) study of the Gamma Knife, a nuclear medical device used for the gamma irradiation of intracranial lesions. Focus was on the physical aspects of QA and did not address issues that are essentially medical, such as patient selection or prescription of dose. A risk-based QA assessment approach was used. Sample programs for quality control and assurance are included. The use of the Gamma Knife was found to conform to existing standards and guidelines concerning radiation safety and quality control of external beam therapies (shielding, safety reviews, radiation surveys, interlock systems, exposure monitoring, good medical physics practices, etc.) and to be compliant with NRC teletherapy regulations. There are, however, current practices for the Gamma Knife not covered by existing, formalized regulations, standards, or guidelines. These practices have been adopted by Gamma Knife users and continue to be developed with further experience. Some of these have appeared in publications or presentations and are slowly finding their way into recommendations of professional organizations.

Development of a quality assurance program for ionizing radiation secondary calibration laboratories

Energy Technology Data Exchange (ETDEWEB)

Heaton, H.T. II; Taylor, A.R. Jr. [Center for Devices and Radiological Health, Rockville, MD (United States)

1993-12-31

For calibration laboratories, routine calibrations of instruments meeting stated accuracy goals are important. One method of achieving the accuracy goals is to establish and follow a quality assurance program designed to monitor all aspects of the calibration program and to provide the appropriate feedback mechanism if adjustments are needed. In the United States there are a number of organizations with laboratory accreditation programs. All existing accreditation programs require that the laboratory implement a quality assurance program with essentially the same elements in all of these programs. Collectively, these elements have been designated as a Measurement Quality Assurance (MQA) program. This paper will briefly discuss the interrelationship of the elements of an MQA program. Using the Center for Devices and Radiological Health (CDRH) X-ray Calibration Laboratory (XCL) as an example, it will focus on setting up a quality control program for the equipment in a Secondary Calibration Laboratory.

Development of a quality assurance program for ionizing radiation secondary calibration laboratories

International Nuclear Information System (INIS)

Heaton, H.T. II; Taylor, A.R. Jr.

1993-01-01

For calibration laboratories, routine calibrations of instruments meeting stated accuracy goals are important. One method of achieving the accuracy goals is to establish and follow a quality assurance program designed to monitor all aspects of the calibration program and to provide the appropriate feedback mechanism if adjustments are needed. In the United States there are a number of organizations with laboratory accreditation programs. All existing accreditation programs require that the laboratory implement a quality assurance program with essentially the same elements in all of these programs. Collectively, these elements have been designated as a Measurement Quality Assurance (MQA) program. This paper will briefly discuss the interrelationship of the elements of an MQA program. Using the Center for Devices and Radiological Health (CDRH) X-ray Calibration Laboratory (XCL) as an example, it will focus on setting up a quality control program for the equipment in a Secondary Calibration Laboratory

78 FR 64507 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-10-29

... Emphasis Panel; Small Business: Cell, Computational and Molecular Biology. Date: November 6, 2013. Time: 8...: Orthopedic and Skeletal Biology. Date: November 6-7, 2013. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and... Committee: Center for Scientific Review Special Emphasis Panel; Diabetes and Metabolism. Date: November 6...

Information Assurance within the United States Air Force

Science.gov (United States)

Cherry, John D.

2010-01-01

According to the Department of Defense (DoD), a review of information assurance (IA) in the United States Air Force (USAF) in 2009, cyber security is jeopardized because of information loss. This situation has occurred in large part because of less than optimal training practices or adherence to training protocols. The purpose of this study was…

A Functional Model of Quality Assurance for Psychiatric Hospitals and Corresponding Staffing Requirements.

Science.gov (United States)

Kamis-Gould, Edna; And Others

1991-01-01

A model for quality assurance (QA) in psychiatric hospitals is described. Its functions (general QA, utilization review, clinical records, evaluation, management information systems, risk management, and infection control), subfunctions, and corresponding staffing requirements are reviewed. This model was designed to foster standardization in QA…

Computer software quality assurance

International Nuclear Information System (INIS)

Ives, K.A.

1986-06-01

The author defines some criteria for the evaluation of software quality assurance elements for applicability to the regulation of the nuclear industry. The author then analyses a number of software quality assurance (SQA) standards. The major extracted SQA elements are then discussed, and finally specific software quality assurance recommendations are made for the nuclear industry

76 FR 72208 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-11-22

... 20892, (301) 402-4411, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis Panel, Studies in...

75 FR 9911 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-03-04

... 20892. 301-435-1169. [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee...-408-9164. [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis...

75 FR 11895 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-03-12

.... (301) 435- 1258. [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis Panel, Member Conflict...

75 FR 56115 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-09-15

... days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name.... (301) 435- 1046. [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis..., Bethesda, MD 20892. 301-435- 1052. [email protected]csr.nih.gov . Name of Committee: Biobehavioral and Behavioral...

78 FR 36201 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-06-17

..., Computational, and Molecular Biology. Date: July 11, 2013. Time: 10:00 a.m. to 6:00 p.m. Agenda: To review and... Panel; Member Conflict: Cancer Biology. Date: July 17, 2013. Time: 2:00 p.m. to 4:00 p.m. Agenda: To...: Center for Scientific Review Special Emphasis Panel; Member Conflict: Molecular Neurogenetics and...

Quality assurance for electronic portal imaging devices

International Nuclear Information System (INIS)

Shalev, S.; Rajapakshe, R.; Gluhchev, G.; Luchka, K.

1997-01-01

Electronic portal imaging devices (EPIDS) are assuming an ever-increasing role in the verification of radiation treatment accuracy. They are used both in a passive capacity, for the determination of field displacement distributions (''setup errors''), and also in an active role whereby the patient setup is corrected on the basis of electronic portal images. In spite of their potential impact on the precision of patient treatment, there are few quality assurance procedures available, and most of the EPIDS in clinical use are subject, at best, to only perfunctory quality assurance. The goals of this work are (a) to develop an objective and reproducible test for EPID image quality on the factory floor and during installation of the EPID on site; (b) to provide the user with a simple and accurate tool for acceptance, commissioning, and routine quality control; and (c) to initiate regional, national and international collaboration in the implementation of standardized, objective, and automated quality assurance procedures. To this end we have developed an automated test in which a simple test object is imaged daily, and the spatial and contrast resolution of the EPID are automatically evaluated in terms of ''acceptable'', ''warning'' and ''stop'' criteria. Our experience over two years shows the test to be highly sensitive, reproducible, and inexpensive in time and effort. Inter-institutional trials are under way in Canada, US and Europe which indicate large variations in EPID image quality from one EPID to another, and from one center to another. We expect the new standardized quality assurance procedure to lead to improved, and consistent image quality, increased operator acceptance of the technology, and agreement on uniform standards by equipment suppliers and health care agencies. (author)

76 FR 28237 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-05-16

... commercial property such as patentable material, and personal information concerning individuals associated... Committee: Center for Scientific Review Special Emphasis Panel, Societal and Ethical Issues in Research...

77 FR 66855 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-11-07

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Gene Discover...-HIV Diagnostics, Food Safety, Sterilization/Disinfection and Bioremediation. Date: November 15-16...

77 FR 73666 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-12-11

... Emphasis Panel; Integrative, Functional, and Cognitive Neuroscience Member Conflicts: Hearing and Taste... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict...

Application of NASA Kennedy Space Center system assurance analysis methodology to nuclear power plant systems designs

International Nuclear Information System (INIS)

Page, D.W.

1985-01-01

The Kennedy Space Center (KSC) entered into an agreement with the Nuclear Regulatory Commission (NRC) to conduct a study to demonstrate the feasibility and practicality of applying the KSC System Assurance Analysis (SAA) methodology to nuclear power plant systems designs. In joint meetings of KSC and Duke Power personnel, an agreement was made to select to CATAWBA systems, the Containment Spray System and the Residual Heat Removal System, for the analyses. Duke Power provided KSC with a full set a Final Safety Analysis Reports as well as schematics for the two systems. During Phase I of the study the reliability analyses of the SAA were performed. During Phase II the hazard analyses were performed. The final product of Phase II is a handbook for implementing the SAA methodology into nuclear power plant systems designs. The purpose of this paper is to describe the SAA methodology as it applies to nuclear power plant systems designs and to discuss the feasibility of its application. The conclusion is drawn that nuclear power plant systems and aerospace ground support systems are similar in complexity and design and share common safety and reliability goals. The SAA methodology is readily adaptable to nuclear power plant designs because of it's practical application of existing and well known safety and reliability analytical techniques tied to an effective management information system

Design, development, and implementation of the Radiological Physics Center's pelvis and thorax anthropomorphic quality assurance phantoms

International Nuclear Information System (INIS)

Followill, David S.; Radford Evans, DeeAnn; Cherry, Christopher; Molineu, Andrea; Fisher, Gary; Hanson, William F.; Ibbott, Geoffrey S.

2007-01-01

The Radiological Physics Center (RPC) developed two heterogeneous anthropomorphic quality assurance phantoms for use in verifying the accuracy of radiation delivery: one for intensity-modulated radiation therapy (IMRT) to the pelvis and the other for stereotactic body radiation therapy (SBRT) to the thorax. The purpose of this study was to describe the design and development of these two phantoms and to demonstrate the reproducibility of measurements generated with them. The phantoms were built to simulate actual patient anatomy. They are lightweight and water-fillable, and they contain imageable targets and organs at risk of radiation exposure that are of similar densities to their human counterparts. Dosimetry inserts accommodate radiochromic film for relative dosimetry and thermoluminesent dosimetry capsules for absolute dosimetry. As a part of the commissioning process, each phantom was imaged, treatment plans were developed, and radiation was delivered at least three times. Under these controlled irradiation conditions, the reproducibility of dose delivery to the target TLD in the pelvis and thorax phantoms was 3% and 0.5%, respectively. The reproducibility of radiation-field localization was less than 2.5 mm for both phantoms. Using these anthropomorphic phantoms, pelvic IMRT and thoracic SBRT radiation treatments can be verified with a high level of precision. These phantoms can be used to effectively credential institutions for participation in specific NCI-sponsored clinical trials

Inside the Black Box: The Case Review Process of an Elder Abuse Forensic Center.

Science.gov (United States)

Navarro, Adria E; Wysong, Julia; DeLiema, Marguerite; Schwartz, Elizabeth L; Nichol, Michael B; Wilber, Kathleen H

2016-08-01

Preliminary evidence suggests that elder abuse forensic centers improve victim welfare by increasing necessary prosecutions and conservatorships and reducing the recurrence of protective service referrals. Center team members gather information and make decisions designed to protect clients and their assets, yet the collective process of how these case reviews are conducted remains unexamined. The purpose of this study is to present a model describing the interprofessional approach of investigation and response to financial exploitation (FE), a frequent and complex type of abuse of vulnerable adults. To develop an understanding of the case review process at the Los Angeles County Elder Abuse Forensic Center (Center), a quasi-Delphi field study approach was used involving direct observations of meetings, surveying team members, and review from the Center's Advisory Council. The goal of this iterative analysis was to understand the case review process for suspected FE in Los Angeles County. A process map of key forensic center elements was developed that may be useful for replication in other settings. The process map includes: (a) multidisciplinary data collection, (b) key decisions for consideration, and (c) strategic actions utilized by an interprofessional team focused on elder justice. Elder justice relies on a complex system of providers. Elder abuse forensic centers provide a process designed to efficiently address client safety, client welfare, and protection of assets. Study findings provide a process map that may help other communities replicate an established multidisciplinary team, one experienced with justice system outcomes designed to protect FE victims. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Data Quality Assurance Governance

OpenAIRE

Montserrat Gonzalez; Stephanie Suhr

2016-01-01

This deliverable describes the ELIXIR-EXCELERATE Quality Management Strategy, addressing EXCELERATE Ethics requirement no. 5 on Data Quality Assurance Governance. The strategy describes the essential procedures and practices within ELIXIR-EXCELERATE concerning planning of quality management, performing quality assurance and controlling quality. It also depicts the overall organisation of ELIXIR with emphasis on authority and specific responsibilities related to quality assurance.

76 FR 72208 - Center for Scientific Review; Notice of Closed Meeting

Science.gov (United States)

2011-11-22

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C...: Mitosis and Meiosis. Date: December 13-14, 2011. Time: 9 a.m. to 5 p.m. Agenda: To review and evaluate...

78 FR 9706 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-02-11

...: Tools for Zebrafish Research. Date: March 5-6, 2013. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and... Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Lipid Metabolism and....333, Clinical Research, 93.306, 93.333, 93.337, 93.393-93.396, 93.837-93.844, 93.846-93.878, 93.892...

77 FR 60706 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-10-04

... Network Analysis and Health. Date: November 1, 2012. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and... Panel, Small Business: Sensory Technologies. Date: November 1-2, 2012. Time: 8:00 a.m. to 5:00 p.m... . Name of Committee: Center for Scientific Review Special Emphasis Panel, Fellowships: Sensory and Motor...

77 FR 62246 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-10-12

[email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific Review Special..., 6701 Rockledge Drive, Room 5208, MSC 7852, Bethesda, MD 20892, (301) 435-1165, [email protected]csr.nih.gov...

76 FR 63315 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-10-12

[email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific Review Special... Rockledge Drive, Room 5110, MSC 7854, Bethesda, MD 20892, (301) 435-1174, [email protected]csr.nih.gov . Name of...

75 FR 8370 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-02-24

[email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for Scientific Review Special..., Bethesda, MD 20892. 301-435-1159. [email protected]csr.nih.gov . This notice is being published less than 15...

77 FR 14533 - Center for Scientific Review: Notice of Closed Meetings

Science.gov (United States)

2012-03-12

..., Bethesda, MD 20892, 301-408- 9971, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of...-435-1236, [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis...

75 FR 9908 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-03-04

..., Room 4102, MSC 7814, Bethesda, MD 20892, (301) 435-1786, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Program Project...

76 FR 13421 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-03-11

..., Room 3136, MSC 7759, Bethesda, MD 20892. (301) 435-1258. [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and.... [email protected]csr.nih.gov . Name of Committee: Center for Scientific Review Special Emphasis Panel, Cancer...

77 FR 32652 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-06-01

... Molecular Genetics A Study Section. Date: June 25, 2012. Time: 8:00 a.m. to 6:00 p.m. Agenda: To review and... . Name of Committee: Center for Scientific Review Special Emphasis Panel Skeletal Muscle Biology... Research in Diabetes, Obesity and Endocrine Disorders. Date: June 27, 2012. Time: 8:00 a.m. to 6:00 p.m...

78 FR 15373 - Center for Scientific Review; Notice of Closed Meeting

Science.gov (United States)

2013-03-11

....S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C...). Contact Person: Yi-Hsin Liu, Ph.D., Scientific Review Officer, Center for Scientific Review, National...

76 FR 36931 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-06-23

... U.S.C. App.), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C...: Yi-Hsin Liu, PhD, Scientific Review Officer, Center for Scientific Review, National Institutes of...

75 FR 51082 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-08-18

... U.S.C. App.), notice is hereby given of the following meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C... Conference Call). Contact Person: Yi-Hsin Liu, PhD, Scientific Review Officer, Center for Scientific Review...

77 FR 511 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-01-05

... Emphasis Panel, PAR-11-228: Shared Instrumentation: Cell Biology, Physiology and Robotics. Date: February 1...: Center for Scientific Review Special Emphasis Panel, Multidisciplinary Healthcare Delivery Research AREA...

78 FR 35292 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-06-12

... Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Child and Adolescent....gov . (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333...

77 FR 5260 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-02-02

... Special Emphasis Panel; Member Conflict: Integrative and Functional Neuroscience. Date: February 28-29... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflicts...

76 FR 21385 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-04-15

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel, Member Conflict[email protected] . Name of Committee: Integrative, Functional and Cognitive Neuroscience [[Page 21386...

76 FR 10382 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-02-24

... Biomedicine and Agriculture: Infectious Diseases, Immunology and the Circulatory System. Date: March 21, 2011... Committee: Center for Scientific Review Special Emphasis Panel; Bioengineering Special Topics. Date: March...

Project specific quality assurance plan for Project W-178, 219-S secondary containment

International Nuclear Information System (INIS)

Buckles, D.I.

1994-01-01

The scope of this Quality Assurance Program Plan (QAPP) is to provide a system of Quality Assurance reviews and verifications on the design, procurement and construction of the 219-S Secondary Containment Upgrade. The reviews and verifications will be on activities associated with design, procurement, and construction of the Secondary Containment Upgrade which includes, but is not limited to demolition, removal, new tank installation, tank 103 isolation, tank cell refurbishment, electrical, instrumentation, piping/tubing including supports, pump and valves, and special coatings. The full project scope is defined in the project Functional Design Criteria (FDC), SD-W178-FDC-001, and all activities must be in compliance with this FDC and related design documentation

Quality assurance in NDT

International Nuclear Information System (INIS)

Krishnamoorthy, K.

2010-01-01

The importance of Nondestructive Testing (NDT) as a Quality Control/Quality Assurance tool in the industrial domain cannot be over-emphasized. With the rapid advancement in research and technology, the NDT field is becoming larger and more sophisticated day by day. Innovative research in materials science and digital technology is paving the way for more and more new methods in NDT technology. Although the NDT technology has improved over the years, the basic 'human factor' underlying the success of the NDT field remains the same. There are two major factors that influence the 'Quality Assurance in NDT'. First, knowledgeable and skilled NDT Operators are the most important factor in assuring the reliable test results. Second, the Management oversight of the NDT operations plays a major role in assuring the overall quality of NDT. Management responsibilities include the implementation of a Quality Management System (QMS) that focuses on the NDT operations and apply all the elements of Quality Assurance relevant to NDT. Whether the NDT operations are performed in-house or by a contractor, periodic Management Self-assessments should include the following question: How can the Management assess and improve the 'Quality Assurance in NDT'? This paper attempts to answer the above question. Some practical examples are provided to illustrate the potential quality incidents that could lead to costly failures, and the role of NDT Operator and the Management in preventing such quality incidents. Also, some guidelines are provided on how the Management can apply the elements of Quality Assurance to NDT in order to assess and improve the 'Quality Assurance in NDT'. (author)

Closing the Gap: The Maturing of Quality Assurance in Australian University Libraries

Science.gov (United States)

Tang, Karen

2012-01-01

A benchmarking review of the quality assurance practices of the libraries of the Australian Technology Network conducted in 2006 revealed exemplars of best practice, but also sector-wide gaps. A follow-up review in 2010 indicated the best practices that remain relevant. While some gaps persist, there has been improvement across the libraries and…

78 FR 66371 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-11-05

....gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflicts: Child... . (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical...

77 FR 61009 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-10-05

... Committee: Center for Scientific Review Special Emphasis Panel; Program Project: Prenatal Stress and Child..., [email protected] . (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine...

75 FR 3912 - Center for Scientific Review; Notice of Closed Meeting

Science.gov (United States)

2010-01-25

... (Telephone Conference Call). Contact Person: Lawrence Baizer, PhD, Scientific Review Officer, Center for... Health, HHS) Dated: January 15, 2010. Jennifer Spaeth, Director, Office of Federal Advisory Committee...

75 FR 33627 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-06-14

... review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M Street, NW., Washington, DC... grant applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue...

Review of optical wireless communications for data centers

Science.gov (United States)

Arnon, Shlomi

2017-10-01

A data center (DC) is a facility either physical or virtual, for running applications, searching, storage, management and dissemination of information known as cloud computing, which consume a huge amount of energy. A DC includes thousands of servers, communication and storage equipment and a support system including an air conditioning system, security, monitoring equipment and electricity regulator units. Data center operators face the challenges of meeting exponentially increasing demands for network bandwidth without unreasonable increases in operation and infrastructure cost. In order to meet the requirements of moderate increase in operation and infrastructure cost technology, a revolution is required. One way to overcome the shortcomings of traditional static (wired) data center architectures is use of a hybrid network based on fiber and optical wireless communication (OWC) or free space optics (FSO). The OWC link could be deployed on top of the existing cable/fiber network layer, so that live migration could be done easily and dynamically. In that case the network topology is flexible and adapts quickly to changes in traffic, heat distribution, power consumption and characteristics of the applications. In addition, OWC could provide an easy way to maintain and scale up data centers. As a result total cost of ownership could be reduced and the return on investment could be increased. In this talk we will review the main OWC technologies applicable for data centers, indicate how energy could be saved using OWC multichannel communication and discuss the issue of OWC pointing accuracy for data center scenario.

The Concepts of Quality, Quality Assurance and Quality Enhancement

Science.gov (United States)

Elassy, Noha

2015-01-01

Purpose: This paper aims to critically review and discuss different definitions of the concepts of quality, quality assurance (QA) and quality enhancement (QE) in higher education (HE) with presenting critical perspectives of the literature. Design/methodology/approach: The paper looks at literature concerns with the meaning of quality, QA and QE,…

Assurance of Myeloid Growth Factor Administration in an Infusion Center: Pilot Quality Improvement Initiative.

Science.gov (United States)

Ramirez, Pamela Maree; Peterson, Barry; Holtshopple, Christine; Borja, Kristina; Torres, Vincent; Valdivia-Peppers, Lucille; Harriague, Julio; Joe, Melanie D

2017-12-01

Four incident reports involving missed doses of myeloid growth factors (MGFs) triggered the need for an outcome-driven initiative. From March 1, 2015, to February 29, 2016, at University of California Irvine Health Chao Infusion Center, 116 of 3,300 MGF doses were missed (3.52%), including pegfilgrastim, filgrastim, and sargramostim. We hypothesized that with the application of Lean Six Sigma methodology, we would achieve our primary objective of reducing the number of missed MGF doses to < 0.5%. This quality improvement initiative was conducted at Chao Infusion Center as part of a Lean Six Sigma Green Belt Certification Program. Therefore, Lean Six Sigma principles and tools were used throughout each phase of the project. Retrospective and prospective medical record reviews and data analyses were performed to evaluate the extent of the identified problem and impact of the process changes. Improvements included systems applications, practice changes, process modifications, and safety-net procedures. Preintervention, 24 missed doses (20.7%) required patient supportive care measures, resulting in increased hospital costs and decreased quality of care. Postintervention, from June 8, 2016, to August 7, 2016, zero of 489 MGF doses were missed after 2 months of intervention ( P < .001). Chao Infusion Center reduced missed doses from 3.52% to 0%, reaching the goal of < 0.5%. The establishment of simplified and standardized processes with safety checks for error prevention increased quality of care. Lean Six Sigma methodology can be applied by other institutions to produce positive outcomes and implement similar practice changes.

Quality assurance

OpenAIRE

Cauchi, Maurice A.M.

1993-01-01

The concept of quality assurance refers more specifically to the process of objectifying and clearly enunciating goals, and providing means of assessing the outcomes. In this article the author mentions four fundamental elements of quality assurance which should be applied in the medical profession in Malta. These elements should relate to professional performance, resource utilisation, risk management and patient satisfaction. The aim of the medical professionals in Malta is to provide the b...

Current status of quality assurance of treatment planning systems

International Nuclear Information System (INIS)

Mijnheer, B.J.

1997-01-01

A review is given of the current status of quality assurance of treatment planning systems. At this moment only one comprehensive report is available. In order to review national activities a questionnaire has been distributed amongst national societies of medical physicists. From the 23 responding countries, 8 indicated that only limited efforts are underway, 8 answered that a working group is evaluating their specific national requirements while in 5 countries a document is drafted. The highlights of these reports have been summarized. (author)

Proactive quality assurance in environmental research

International Nuclear Information System (INIS)

Flanagan, J.B.; Kulkarni, S.V.; Wasson, S.J.; Ford, J.S.; Harmon, D.L.

1991-01-01

The Quality Assurance policy of the US Environmental Protection Agency (EPA) stipulates that every project involving environmentally related monitoring, measurements, and data collection activities must have a written and approved quality assurance project plan (QAPjP). A QAPjP is a written document which presents, in specific terms, the policies, organizations, objectives, functional activities, and the quality assurance/quality control activities designed to achieve the quality goals for data collection. In the research studies involving novel or non-routine measurements that use unvalidated methods, measurement quality goals are often difficult or impossible to specify at the beginning of the project for which a QAPjP must be written. Furthermore, it may not be possible for the QAPjP reviewers to evaluate the reasonableness of these goals without initial information about the system under study. For the project to evaluate chlorofluorocarbon for recycling from domestic refrigerators, the QAPjP incorporated standard analytical techniques used by industry. These techniques did not provide accuracy and precision or other validation information. For the initial version of the QAPjP, measurement quality goals were assigned based on limited experience. Quality assurance support was called upon to evaluate the performance of the measurement system for this project through a series of audits. The performance evaluation audits necessitated designing novel audit materials and sample delivery techniques. Continued interaction is necessary between the project and QA teams to permit evolution of reasonable data quality indicators for meaningful assessment of data quality. By treating the QAPjP as a living document that is updated and amended as more knowledge of a system is obtained, AQ becomes an integral part of the research program. This results in a greater understanding of the system under study

78 FR 60293 - Center for Scientific Review; Notice of Closed Meeting

Science.gov (United States)

2013-10-01

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Stem Cell... Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical Research, 93.306...

77 FR 2073 - Center for Scientific Review Notice of Closed Meetings

Science.gov (United States)

2012-01-13

... 2--Translational Clinical Integrated Review Group; Basic Mechanisms of Cancer Therapeutics Study... Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Fouad A El-Zaatari, Ph.D...

76 FR 55076 - Center for Scientific Review Notice of Closed Meetings

Science.gov (United States)

2011-09-06

... applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, Bethesda, MD 20814. Contact Person... review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M Street, NW., Washington, DC...

Literature Review on Modeling Cyber Networks and Evaluating Cyber Risks.

Energy Technology Data Exchange (ETDEWEB)

Kelic, Andjelka; Campbell, Philip L

2018-04-01

The National Infrastructure Simulations and Analysis Center (NISAC) conducted a literature review on modeling cyber networks and evaluating cyber risks. The literature review explores where modeling is used in the cyber regime and ways that consequence and risk are evaluated. The relevant literature clusters in three different spaces: network security, cyber-physical, and mission assurance. In all approaches, some form of modeling is utilized at varying levels of detail, while the ability to understand consequence varies, as do interpretations of risk. This document summarizes the different literature viewpoints and explores their applicability to securing enterprise networks.

Specified assurance level sampling procedure

International Nuclear Information System (INIS)

Willner, O.

1980-11-01

In the nuclear industry design specifications for certain quality characteristics require that the final product be inspected by a sampling plan which can demonstrate product conformance to stated assurance levels. The Specified Assurance Level (SAL) Sampling Procedure has been developed to permit the direct selection of attribute sampling plans which can meet commonly used assurance levels. The SAL procedure contains sampling plans which yield the minimum sample size at stated assurance levels. The SAL procedure also provides sampling plans with acceptance numbers ranging from 0 to 10, thus, making available to the user a wide choice of plans all designed to comply with a stated assurance level

77 FR 67015 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-11-08

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C...: Mitosis and Meiosis. Date: November 27-28, 2012. Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and...

75 FR 4576 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-01-28

...: Center for Scientific Review Special Emphasis Panel, Academic-Industry Partnership in Cancer Imaging.... Place: Ritz Carlton Hotel, 1150 22nd Street, NW., Washington, DC 20037. Contact Person: Fouad A. El...

77 FR 5259 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-02-02

.... Place: Bethesda North Marriott & Conference Center, 5701 Marinelli Road, North Bethesda, MD 20852...:30 p.m. Agenda: To review and evaluate grant applications. Place: Marina del Rey Hotel, 13534 Bali...

Quality assurance program in the External dosimetry laboratory of the CPHR

International Nuclear Information System (INIS)

Molina P, D.; Pernas S, R.; Martinez H, E.; Cardenas H, J.

2006-01-01

From 1999 the Laboratory of External Dosimetry of the Radiation Protection and Hygiene Center comes applying in its service of personal dosimetry a Program of Quality Assurance. This program was designed according to the recommendations of national and international organizations as the National Assuring Office of the Republic of Cuba (ONARC), the International Standards Organization (ISO), the International Electro technique Commission (IEC) and the International Atomic Energy Agency (IAEA). In this work it is presented in a summarized way the operation of this Program of Quality Assurance which includes the administration and conservation of the results and the documentation of the service, the controls that are carried out to the equipment, the acceptance tests that are applied to the equipment and new dosemeters, the shipment and prosecution of the dosemeters, the evaluation, storage and conservation of the doses, the report of the results, the traceability and reproducibility of the measurements, the attention to the reclamations and the clients complaints and the internal and external audits to those that it undergoes periodically the laboratory. (Author)

Review: The procurement, storage and quality assurance of frozen blood and tissue biospecimens

Directory of Open Access Journals (Sweden)

Manoj S. Charde

2014-05-01

Full Text Available The preserved frozen biospecimens are ideal for evaluating the genome, transcriptome, and proteome. Here we present a current overview of experimental data regarding procurement, storage, and quality assurance that can informthe handling of frozen biospecimens. Degradation of frozen biospecimens can be affected by collecting methodology, premortem agonal changes and warm ischemic time during surgery.  Tissue storage at− 80 °C can preserve DNA and protein but RNA show degradation at 5 years, therefore storage at − 150 °C provides significant advantages.  Histologic quality assurance of tissue biospecimens is typically performed at the time of surgery but should also be conducted on the aliquot to be distributed because of tissue heterogeneity.Additional qualityassurance testing should be dictated by the anticipated downstream applications.

76 FR 43694 - Center for Scientific Review; Notice of Closed Meeting

Science.gov (United States)

2011-07-21

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflicts: Cystic Fibrosis, Lung Fibrosis, and Lung Innate Immunity Applications. Date: August 8, 2011. Time: 9 a.m...

76 FR 34719 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-06-14

...: Westin Seattle Hotel, 1900 5th Avenue, Seattle, WA 98101. Contact Person: Jose H Guerrier, PhD...: Center for Scientific Review Special Emphasis Panel, Small Business: Respiratory Sciences. Date: July 14...

75 FR 80508 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-12-22

... Panel, Member Conflicts: Cellular and Molecular Immunology. Date: January 7, 2011. Time: 9 a.m. to 6 p.m... of Committee: Center for Scientific Review Special Emphasis Panel, Special Topic: Bioanalytical...

78 FR 36553 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-06-18

...: Revision applications for research on assessing the role of Stigma in HIV prevention and care. Date: [email protected] . Name of Committee: Center for Scientific Review Special Emphasis Panel; Program Project...

78 FR 2679 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-01-14

...; Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section. Date: February 11-12, 2013. Time: [email protected] Name of Committee: Center for Scientific Review Special Emphasis Panel; PAR Panel: Lipids...

The challenge of Quality Assurance

International Nuclear Information System (INIS)

Simon, R.; Price, M.S.T.; Krischer, W.

1985-01-01

The safe terminal containment of hazardous wastes cannot only rely upon the geographic remoteness and the arid climates of the repository sites. Radioactive and permanently toxic chemical wastes must by prevented from returning to the human environment by natural and engineered barriers. The long-term integrity of these barriers and the safety of waste emplacement operation will be controlled by systematic actions under the common objective of Quality Assurance (QA). The following paper presents the aims of QA in the design and production of waste packages. It lists the most relevant acceptance criteria and regulatory requirements, investigates the institutional and technical problems of carrying out Quality Assurance and presents suggestions for establishing suitable organizational structures and technical programmes to provide adequate confidence in the safe nature and the performance of waste packages. In view of the technical difficulties of verifying the compliance of industrially produced waste forms with the acceptance criteria, the CEC has laid emphasis on the development of appropriate test methods in its last R and D programme. First results of the work are reviewed in the context of international progress in this field

Langley Research Center Strategic Plan for Education

Science.gov (United States)

Proctor, Sandra B.

1994-01-01

Research assignment centered on the preparation of final draft of the NASA Langley Strategic Plan for Education. Primary research activity consisted of data collection, through interviews with LaRC Office of Education and NASA Headquarters staff, university administrators and faculty, and school administrators / teachers; and documentary analysis. Pre-college and university programs were critically reviewed to assure effectiveness, support of NASA and Langley's mission and goals; National Education Goals; and educational reform strategies. In addition to these mandates, pre-college programs were reviewed to address present and future LaRC activities for teacher enhancement and preparation. University programs were reviewed with emphasis on student support and recruitment; faculty development and enhancement; and LaRC's role in promoting the utilization of educational technologies and distance learning. The LaRC Strategic Plan for Education will enable the Office of Education to provide a focused and well planned continuum of education programs for students, teachers and faculty. It will serve to direct and focus present activities and programs while simultaneously offering the flexibility to address new and emerging directions based on changing national, state, and agency trends.

78 FR 60297 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-10-01

..., Rockville, MD 20852. Contact Person: Leonid V. Tsap, Ph.D., Scientific Review Officer, Center for Scientific...: Residence Inn Bethesda, 7335 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Patrick K Lai, Ph.D...

78 FR 735 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-01-04

..., CA 94102. Contact Person: Eileen W Bradley, DSC, Scientific Review Officer, Center for Scientific...-93.878, 93.892, 93.893, National Institutes of Health, HHS) Dated: December 31, 2012. Melanie J. Gray...

77 FR 61614 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-10-10

....gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Fellowships: Brain...: Endocrinology, Metabolism, Nutrition and Reproduction. Date: November 8, 2012. Time: 1 p.m. to 5 p.m. Agenda: To...

75 FR 5602 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-02-03

..., and Social Implications of Human Genetics Study Section. Date: February 23, 2010. Time: 8:30 a.m. to 4... Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict: Immune Mechanisms. Date...

10 CFR 71.37 - Quality assurance.

Science.gov (United States)

2010-01-01

... 10 Energy 2 2010-01-01 2010-01-01 false Quality assurance. 71.37 Section 71.37 Energy NUCLEAR... Package Approval § 71.37 Quality assurance. (a) The applicant shall describe the quality assurance program... quality assurance program that are applicable to the particular package design under consideration...

76 FR 63312 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-10-12

...: Lawrence E Boerboom, PhD, Chief, CVRS IRG, Center for Scientific Review, National Institutes of Health.... Jennifer S. Spaeth, Director, Office of Federal Advisory Committee Policy. [FR Doc. 2011-26355 Filed 10-11...

Reliability assurance program for operational emergency ac power system

International Nuclear Information System (INIS)

Heineman, J.B.; Ragland, W.A.; Mueller, C.J.

1985-01-01

A comprehensive review of emergency ac power systems in nuclear generating plants (the vast majority of these plants contain redundant diesel generator systems) delineates several operational areas that can be improved by instituting a reliability assurance program (RAP), which initially upgrades the diesel generator performance and provides for ongoing monitoring and maintenance based upon alert levels

Quality-Assurance Program Plan

International Nuclear Information System (INIS)

Kettell, R.A.

1981-05-01

This Quality Assurance Program Plan (QAPP) is provided to describe the Quality Assurance Program which is applied to the waste management activities conducted by AESD-Nevada Operations at the E-MAD Facility located in Area 25 of the Nevada Test Site. The AESD-Nevada Operations QAPP provides the necessary systematic and administrative controls to assure activities that affect quality, safety, reliability, and maintainability during design, procurement, fabrication, inspection, shipments, tests, and storage are conducted in accordance with established requirements

Quality-assurance plan for water-resources activities of the U.S. Geological Survey in Idaho

Science.gov (United States)

Packard, F.A.

1996-01-01

To ensure continued confidence in its products, the Water Resources Division of the U.S. Geological Survey implemented a policy that all its scientific work be performed in accordance with a centrally managed quality-assurance program. This report establishes and documents a formal policy for current (1995) quality assurance within the Idaho District of the U.S. Geological Survey. Quality assurance is formalized by describing district organization and operational responsibilities, documenting the district quality-assurance policies, and describing district functions. The districts conducts its work through offices in Boise, Idaho Falls, Twin Falls, Sandpoint, and at the Idaho National Engineering Laboratory. Data-collection programs and interpretive studies are conducted by two operating units, and operational and technical assistance is provided by three support units: (1) Administrative Services advisors provide guidance on various personnel issues and budget functions, (2) computer and reports advisors provide guidance in their fields, and (3) discipline specialists provide technical advice and assistance to the district and to chiefs of various projects. The district's quality-assurance plan is based on an overall policy that provides a framework for defining the precision and accuracy of collected data. The plan is supported by a series of quality-assurance policy statements that describe responsibilities for specific operations in the district's program. The operations are program planning; project planning; project implementation; review and remediation; data collection; equipment calibration and maintenance; data processing and storage; data analysis, synthesis, and interpretation; report preparation and processing; and training. Activities of the district are systematically conducted under a hierarchy of supervision an management that is designed to ensure conformance with Water Resources Division goals quality assurance. The district quality-assurance

77 FR 58852 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-09-24

...: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M... Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person...

Training, Quality Assurance Factors, and Tools Investigation: a Work Report and Suggestions on Software Quality Assurance

Science.gov (United States)

Lee, Pen-Nan

1991-01-01

Previously, several research tasks have been conducted, some observations were obtained, and several possible suggestions have been contemplated involving software quality assurance engineering at NASA Johnson. These research tasks are briefly described. Also, a brief discussion is given on the role of software quality assurance in software engineering along with some observations and suggestions. A brief discussion on a training program for software quality assurance engineers is provided. A list of assurance factors as well as quality factors are also included. Finally, a process model which can be used for searching and collecting software quality assurance tools is presented.

Quality assurance in mammography and the DQM program

International Nuclear Information System (INIS)

Rimondi, O.; Giambaccini, M.; Marziani, M.

1991-01-01

The aim of the optimization program for mammography (DQM) in Italy is to achieve the best compromise between image quality and dose to patient. 272 centers agreed to the second phase of the program, from February 1987 to January 1990. Exposure, half-value layer (HVL) and focal spot size were measured according to the same methods employed in the first phase of the DQM program (1985), while image quality was evaluated by means of a new performance phantom. The average exposure was 0.96 R (2.48x10 -4 C/Kg); in 173 (64.3%) centers exposure was 5 R (12.9x10 -4 C/Kg). In every center the average whole-breast dose to a reference organ (5cm thick, composed of 50% fat +50% water) was calculated on the basis of entrance exposure, HVL, and focus-skin distance; in 63.2% of the centers doses <0.15 cGy were employed. The results allowed dose and image quality to be correlated in order to divide the centers (using a film-screen system) into groups with a different efficiency level: in 101 centers dose and image quality were good, in 64 centers too high a dose was employed, 66 centers image quality was poor, and in 38 centers dose was too high and image quality was poor. It must be stressed that the DQM program can play its role only if each center carries out its Quality Assurance activity after the methods recommended by the World Health Organization

Quality assurance during site construction

International Nuclear Information System (INIS)

Dommke, J.; Jurgutat, H.

1980-01-01

During the time of planing and construction of a nuclear power plant, the following proceeding is approved: - the deliverer of a nuclear power plant provides the reports fixing the quality assurance program, it means that he is responsible to write the safety analysis report, the specifications for the erection of the components, the working manuals and specifications for testing (eg nondestr. testing) - the manufacturing of components or systems will be controlled by an own independent quality assurance group, provided that this group was checked by the quality assurance group of the applicant - the TUeV with its independent assessors will fix the requirements relating to quality assurance in its assessment. On this basis the examination of the applicants specifications, working manuals, testing specifications will be done. The efficiency of quality assurance at the manufacturer and at the applicant will be checked by the TUeV specialists by considering specifications of modifications, repairs or tolerances. A mean point of the quality assurance in Germany is the dynamic adjustment, of an action on the latest state of engineering or science. If there exists a change of rules or guidelines, the quality assurance requirements have to be fit on this state in so far as it is feasible from the technical point of view. (orig./RW)

76 FR 62082 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-10-06

... Committee: Center for Scientific Review Special Emphasis Panel, AREA applications in Child and Adult..., Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393-93.396, 93.837-93.844, 93.846...

Randomized trials and quality assurance in gastric cancer surgery.

Science.gov (United States)

Dikken, Johan L; Cats, Annemieke; Verheij, Marcel; van de Velde, Cornelis J H

2013-03-01

A D2 lymphadenectomy can be considered standard of surgical care for advanced resectable gastric cancer. Currently, several multimodality strategies are used, including postoperative monochemotherapy in Asia, postoperative chemoradiotherapy in the United States, and perioperative chemotherapy in Europe. As the majority of gastric cancer patients are treated outside the framework of clinical trials, quality assurance programs, including referral to high-volume centers and clinical auditing are needed to improve gastric cancer care on a nationwide level. Copyright © 2012 Wiley Periodicals, Inc.

Quality assurance plan for the Objective Supply Capability Adaptive Redesign (OSCAR) project

Energy Technology Data Exchange (ETDEWEB)

Stewart, K.A.; Rasch, K.A.; Reid, R.W.

1996-11-01

This document establishes the Quality Assurance Plan (QAP) for the National Guard Bureau Objective Supply Capability Adaptive Redesign (OSCAR) project activities under the Oak Ridge National Laboratory (ORNL) management. It defines the requirements and assigns responsibilities for ensuring, with a high degree of confidence, that project objectives will be achieved as planned. The QAP outlined herein is responsive to and meets the Quality Assurance Program standards for the U.S. Department of Energy (DOE), Lockheed Martin Energy Research Corporation and ORNL and the ORNL Computing, Robotics, and Education Directorate (CRE). This document is intended to be in compliance with DOE Order 5700.6C, Quality Assurance Program, and the ORNL Standard Practice Procedure, SPP X-QA-8, Quality Assurance for ORNL Computing Software. This standard allows individual organizations to apply the stated requirements in a flexible manner suitable to the type of activity involved. Section I of this document provides an introduction to the OSCAR project QAP; Sections 2 and 3 describe the specific aspects of quality assurance as applicable to the OSCAR project. Section 4 describes the project approach to risk management. The Risk Management Matrix given in Appendix A is a tool to assess, prioritize, and prevent problems before they occur. Therefore, the matrix will be reviewed and revised on a periodic basis.

User-centered design and the development of patient decision aids: protocol for a systematic review.

Science.gov (United States)

Witteman, Holly O; Dansokho, Selma Chipenda; Colquhoun, Heather; Coulter, Angela; Dugas, Michèle; Fagerlin, Angela; Giguere, Anik Mc; Glouberman, Sholom; Haslett, Lynne; Hoffman, Aubri; Ivers, Noah; Légaré, France; Légaré, Jean; Levin, Carrie; Lopez, Karli; Montori, Victor M; Provencher, Thierry; Renaud, Jean-Sébastien; Sparling, Kerri; Stacey, Dawn; Vaisson, Gratianne; Volk, Robert J; Witteman, William

2015-01-26

Providing patient-centered care requires that patients partner in their personal health-care decisions to the full extent desired. Patient decision aids facilitate processes of shared decision-making between patients and their clinicians by presenting relevant scientific information in balanced, understandable ways, helping clarify patients' goals, and guiding decision-making processes. Although international standards stipulate that patients and clinicians should be involved in decision aid development, little is known about how such involvement currently occurs, let alone best practices. This systematic review consisting of three interlinked subreviews seeks to describe current practices of user involvement in the development of patient decision aids, compare these to practices of user-centered design, and identify promising strategies. A research team that includes patient and clinician representatives, decision aid developers, and systematic review method experts will guide this review according to the Cochrane Handbook and PRISMA reporting guidelines. A medical librarian will hand search key references and use a peer-reviewed search strategy to search MEDLINE, EMBASE, PubMed, Web of Science, the Cochrane Library, the ACM library, IEEE Xplore, and Google Scholar. We will identify articles across all languages and years describing the development or evaluation of a patient decision aid, or the application of user-centered design or human-centered design to tools intended for patient use. Two independent reviewers will assess article eligibility and extract data into a matrix using a structured pilot-tested form based on a conceptual framework of user-centered design. We will synthesize evidence to describe how research teams have included users in their development process and compare these practices to user-centered design methods. If data permit, we will develop a measure of the user-centeredness of development processes and identify practices that are likely

Reliability assurance programme guidebook for advanced light water reactors

International Nuclear Information System (INIS)

2001-12-01

To facilitate the implementation of reliability assurance programmes (RAP) within future advanced reactor programmes and to ensure that the next generation of commercial nuclear reactors achieves the very high levels of safety, reliability and economy which are expected of them, in 1996, the International Atomic Energy Agency (IAEA) established a task to develop a guidebook for reliability assurance programmes. The draft RAP guidebook was prepared by an expert consultant and was reviewed/modified at an Advisory Group meeting (7-10 April 1997) and at a consults meeting (7-10 October 1997). The programme for the RAP guidebook was reported to and guided by the Technical Working Group on Advanced Technologies for Light Water Reactors (TWG-LWR). This guidebook will demonstrate how the designers and operators of future commercial nuclear plants can exploit the risk, reliability and availability engineering methods and techniques developed over the past two decades to augment existing design and operational nuclear plant decision-making capabilities. This guidebook is intended to provide the necessary understanding, insights and examples of RAP management systems and processes from which a future user can derive his own plant specific reliability assurance programmes. The RAP guidebook is intended to augment, not replace, specific reliability assurance requirements defined by the utility requirements documents and by individual nuclear steam supply system (NSSS) designers. This guidebook draws from utility experience gained during implementation of reliability and availability improvement and risk based management programmes to provide both written and diagrammatic 'how to' guidance which can be followed to assure conformance with the specific requirements outlined by utility requirements documents and in the development of a practical and effective plant specific RAP in any IAEA Member State

Authentication Assurance Levels

International Nuclear Information System (INIS)

Kouzes, Richard T.; Cash, James R.; Devaney, David M.; Geelhood, Bruce D.; Hansen, Randy R.; Melton, Ronald B.; Pitts, W. Karl

2002-01-01

This Common Criteria approach has been applied to create a definition of Authentication Assurance Levels that can quantify the level of assurance reached for a system subject to a set of authentication procedures. The arms-control authentication application of the Common Criteria expands on more typical information security evaluations in that it must contend with information barriers and preclude sophisticated intentional subversion attempts.

U.S. comments on co-chairmen WG.2/15, chapter 7-A assurance of supply

International Nuclear Information System (INIS)

1979-05-01

The U.S. delegation proposes revision in chapter 7 regarding assurance of supply, to reflect that alternative suppliers now exist to provide an assured supply, and that for most countries national enrichment facilities would not be practical or economic. The paper also argues that the spread of national facilities could increase proliferation risks. The revised text also argues that, because enrichment is highly capital-intensive, consumers should not expect significant surplus capacity at any given time, and should not interpret the absence of surplus capacity as an indication of lack of assurance in supply. Options which increase a consumer's flexibility in meeting enrichment needs are reviewed

Metrology's role in quality assurance

International Nuclear Information System (INIS)

Zeederberg, L.B.

1982-01-01

Metrology, the science of measurement, is playing an increasing role in modern industry as part of an on-going quality assurance programme. At Escom, quality assurance was critical during the construction of the Koeberg nuclear facility, and also a function in controlling services provided by Escom. This article deals with the role metrology plays in quality assurance

Quality assurance of fuel elements

International Nuclear Information System (INIS)

Hoerber, J.

1980-01-01

The quality assurance activities for reactor fuel elements are based on a quality assurance system which implies the requirements resulting from the specifications, regulations of the authorities, national standards and international rules and regulations. The quality assurance related to production of reactor fuel will be shown for PWR fuel elements in all typical fabrication steps as conversion into UO 2 -powder, pelletizing, rodmanufacture and assembling. A wide range of destructive and nondestructive techniques is applied. Quality assurance is not only verified by testing techniques but also by process monitoring by means of parameter control in production and testing procedures. (RW)

FESA Quality Assurance

CERN Multimedia

CERN. Geneva

2015-01-01

FESA is a framework used by 100+ developers at CERN to design and implement the real-time software used to control the accelerators. Each new version must be tested and qualified to ensure that no backward compatibility issues have been introduced and that there is no major bug which might prevent accelerator operations. Our quality assurance approach is based on code review and a two-level testing process. The first level is made of unit-test (Python unittest & Google tests for C++). The second level consists of integration tests running on an isolated test environment. We also use a continuous integration service (Bamboo) to ensure the tests are executed periodically and the bugs caught early. In the presentation, we will explain the reasons why we took this approach, the results and some thoughts on the pros and cons.

Software quality assurance handbook

Energy Technology Data Exchange (ETDEWEB)

1990-09-01

There are two important reasons for Software Quality Assurance (SQA) at Allied-Signal Inc., Kansas City Division (KCD): First, the benefits from SQA make good business sense. Second, the Department of Energy has requested SQA. This handbook is one of the first steps in a plant-wide implementation of Software Quality Assurance at KCD. The handbook has two main purposes. The first is to provide information that you will need to perform software quality assurance activities. The second is to provide a common thread to unify the approach to SQA at KCD. 2 figs.

UMTRA project technical assistance contractor quality assurance implementation plan

International Nuclear Information System (INIS)

1994-03-01

The Uranium Mill Tailings Remedial Action (UMTRA) Project Technical Assistance contractor (TAC) Quality Assurance Implementation Plan (QAIP) outlines the primary requirements for integrating quality functions for TAC technical activities applied to the surface and ground water phases of the UMTRA Project. The QAIP is subordinate to the latest issue of the UMTRA Project TAC Quality Assurance Program Plan (QAPP) (DOE, 1993a), which was developed using US Department of Energy (DOE) Order 5700.6C quality assurance (QA) criteria. The QAIP addresses technical aspects of the TAC UMTRA Project surface and ground water programs. All QA issues in the QAIP shall comply with requirements contained in the TAC QAPP (DOE, 1933a). Because industry standards for data acquisition and data control are not addressed in DOE Order 5700.6C, the QAIP has been formatted to the 14 US Environmental Protection Agency (EPA) Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) QA requirements. DOE Order 5700.6C criteria that are not contained in the CERCLA requirements are added to the QAIP as additional requirements in Sections 15.0 through 18.0. Project documents that contain CERCLA requirements and 5700.6 criteria shall be referenced in this document to avoid duplication. Referenced documents are not included in this QAIP but are available through the UMTRA Project Document Control Center

Software quality assurance for safety analysis and risk management at the Savannah River Site

International Nuclear Information System (INIS)

Ades, M.J.; Toffer, H.; Crowe, R.D.

1991-01-01

As part of its Reactor Operations Improvement Program at the Savannah River Site (SRS), Westinghouse Savannah River Company (WSRC), in cooperation with the Westinghouse Hanford Company, has developed and implemented quality assurance for safety-related software for technical programs essential to the safety and reliability of reactor operations. More specifically, the quality assurance process involved the development and implementation of quality standards and attendant procedures based on industry software quality standards. These procedures were then applied to computer codes in reactor safety and probabilistic risk assessment analyses. This paper provides a review of the major aspects of the WSRC safety-related software quality assurance. In particular, quality assurance procedures are described for the different life cycle phases of the software that include the Requirements, Software Design and Implementation, Testing and Installation, Operation and Maintenance, and Retirement Phases. For each phase, specific provisions are made to categorize the range of activities, the level of responsibilities, and the documentation needed to assure the control of the software. The software quality assurance procedures developed and implemented are evolutionary in nature, and thus, prone to further refinements. These procedures, nevertheless, represent an effective controlling tool for the development, production, and operation of safety-related software applicable to reactor safety and probabilistic risk assessment analyses

76 FR 14674 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-03-17

...-435- 1033, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of Committee: Center for... 4142, [[Page 14675

78 FR 64224 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-10-28

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Emphasis Panel; Fellowships: Physiology and Pathobiology of Cardiovascular and Respiratory Systems. Date... and Feasibility Clinical Research Studies in Digestive Diseases and Nutrition. Date: November 14, 2013...

International Thermonuclear Experimental Reactor U.S. Home Team Quality Assurance Plan

Energy Technology Data Exchange (ETDEWEB)

Sowder, W. K.

1998-10-01

The International Thermonuclear Experimental Reactor (ITER) project is unique in that the work is divided among an international Joint Central Team and four Home Teams, with the overall responsibility for the quality of activities performed during the project residing with the ITER Director. The ultimate responsibility for the adequacy of work performed on tasks assigned to the U.S. Home Team resides with the U.S. Home Team Leader and the U.S. Department of Energy Office of Fusion Energy (DOE-OFE). This document constitutes the quality assurance plan for the ITER U.S. Home Team. This plan describes the controls exercised by U.S. Home Team management and the Performing Institutions to ensure the quality of tasks performed and the data developed for the Engineering Design Activities assigned to the U.S. Home Team and, in particular, the Research and Development Large Projects (7). This plan addresses the DOE quality assurance requirements of 10 CFR 830.120, "Quality Assurance." The plan also describes U.S. Home Team quality commitments to the ITER Quality Assurance Program. The ITER Quality Assurance Program is based on the principles described in the International Atomic Energy Agency Standard No. 50-C-QA, "Quality Assurance for Safety in Nuclear Power Plants and Other Nuclear Facilities." Each commitment is supported with preferred implementation methodology that will be used in evaluating the task quality plans to be submitted by the Performing Institutions. The implementing provisions of the program are based on guidance provided in American National Standards Institute/American Society of Mechanical Engineers NQA-1 1994, "Quality Assurance." The individual Performing Institutions will implement the appropriate quality program provisions through their own established quality plans that have been reviewed and found to comply with U.S. Home Team quality assurance plan commitments to the ITER Quality Assurance Program. The extent of quality program provisions

42 CFR 423.153 - Drug utilization management, quality assurance, and medication therapy management programs (MTMPs).

Science.gov (United States)

2010-10-01

... PRESCRIPTION DRUG BENEFIT Cost Control and Quality Improvement Requirements § 423.153 Drug utilization... 42 Public Health 3 2010-10-01 2010-10-01 false Drug utilization management, quality assurance, and medication therapy management programs (MTMPs). 423.153 Section 423.153 Public Health CENTERS FOR MEDICARE...

TH-A-BRC-02: AAPM TG-178 Gamma Stereotactic Radiosurgery Dosimetry and Quality Assurance

Energy Technology Data Exchange (ETDEWEB)

Goetsch, S. [San Diego Medical Physics (United States)

2016-06-15

of possible dosimetry protocols. The report will be reviewed by the AAPM Working Group on Recommendations for Radiotherapy External Beam Quality Assurance and then by the AAPM Science Council before publication in Medical Physics Survey of possible calibration protocols for calibration of Gamma Stereotactic Radiosurgery (GSR) devices Overview of modern Quality Assurance techniques for GSR AAPM TG-218 Tolerance Levels and Methodologies for IMRT Verification QA - Moyed Miften Patient-specific IMRT QA measurement is a process designed to identify discrepancies between calculated and delivered doses. Error tolerance limits are not well-defined or consistently applied across centers. The AAPM TG-218 report has been prepared to improve the understanding and consistency of this process by providing recommendations for methodologies and tolerance limits in patient-specific IMRT QA. Learning Objectives: Review measurement methods and methodologies for absolute dose verification Provide recommendations on delivery methods, data interpretation, the use of analysis routines and choice of tolerance limits for IMRT QA Sonja Dieterich has a research agreement with Sun Nuclear Inc. Steven Goetsch is a part-time consultant for Elekta.

TH-A-BRC-02: AAPM TG-178 Gamma Stereotactic Radiosurgery Dosimetry and Quality Assurance

International Nuclear Information System (INIS)

Goetsch, S.

2016-01-01

of possible dosimetry protocols. The report will be reviewed by the AAPM Working Group on Recommendations for Radiotherapy External Beam Quality Assurance and then by the AAPM Science Council before publication in Medical Physics Survey of possible calibration protocols for calibration of Gamma Stereotactic Radiosurgery (GSR) devices Overview of modern Quality Assurance techniques for GSR AAPM TG-218 Tolerance Levels and Methodologies for IMRT Verification QA - Moyed Miften Patient-specific IMRT QA measurement is a process designed to identify discrepancies between calculated and delivered doses. Error tolerance limits are not well-defined or consistently applied across centers. The AAPM TG-218 report has been prepared to improve the understanding and consistency of this process by providing recommendations for methodologies and tolerance limits in patient-specific IMRT QA. Learning Objectives: Review measurement methods and methodologies for absolute dose verification Provide recommendations on delivery methods, data interpretation, the use of analysis routines and choice of tolerance limits for IMRT QA Sonja Dieterich has a research agreement with Sun Nuclear Inc. Steven Goetsch is a part-time consultant for Elekta.

Time required for institutional review board review at one Veterans Affairs medical center.

Science.gov (United States)

Hall, Daniel E; Hanusa, Barbara H; Stone, Roslyn A; Ling, Bruce S; Arnold, Robert M

2015-02-01

Despite growing concern that institutional review boards (IRBs) impose burdensome delays on research, little is known about the time required for IRB review across different types of research. To measure the overall and incremental process times for IRB review as a process of quality improvement. After developing a detailed process flowchart of the IRB review process, 2 analysts abstracted temporal data from the records pertaining to all 103 protocols newly submitted to the IRB at a large urban Veterans Affairs medical center from June 1, 2009, through May 31, 2011. Disagreements were reviewed with the principal investigator to reach consensus. We then compared the review times across review types using analysis of variance and post hoc Scheffé tests after achieving normally distributed data through logarithmic transformation. Calendar days from initial submission to final approval of research protocols. Initial IRB review took 2 to 4 months, with expedited and exempt reviews requiring less time (median [range], 85 [23-631] and 82 [16-437] days, respectively) than full board reviews (median [range], 131 [64-296] days; P = .008). The median time required for credentialing of investigators was 1 day (range, 0-74 days), and review by the research and development committee took a median of 15 days (range, 0-184 days). There were no significant differences in credentialing or research and development times across review types (exempt, expedited, or full board). Of the extreme delays in IRB review, 80.0% were due to investigators' slow responses to requested changes. There were no systematic delays attributable to the information security officer, privacy officer, or IRB chair. Measuring and analyzing review times is a critical first step in establishing a culture and process of continuous quality improvement among IRBs that govern research programs. The review times observed at this IRB are substantially longer than the 60-day target recommended by expert panels

Automated daily quality control analysis for mammography in a multi-unit imaging center.

Science.gov (United States)

Sundell, Veli-Matti; Mäkelä, Teemu; Meaney, Alexander; Kaasalainen, Touko; Savolainen, Sauli

2018-01-01

Background The high requirements for mammography image quality necessitate a systematic quality assurance process. Digital imaging allows automation of the image quality analysis, which can potentially improve repeatability and objectivity compared to a visual evaluation made by the users. Purpose To develop an automatic image quality analysis software for daily mammography quality control in a multi-unit imaging center. Material and Methods An automated image quality analysis software using the discrete wavelet transform and multiresolution analysis was developed for the American College of Radiology accreditation phantom. The software was validated by analyzing 60 randomly selected phantom images from six mammography systems and 20 phantom images with different dose levels from one mammography system. The results were compared to a visual analysis made by four reviewers. Additionally, long-term image quality trends of a full-field digital mammography system and a computed radiography mammography system were investigated. Results The automated software produced feature detection levels comparable to visual analysis. The agreement was good in the case of fibers, while the software detected somewhat more microcalcifications and characteristic masses. Long-term follow-up via a quality assurance web portal demonstrated the feasibility of using the software for monitoring the performance of mammography systems in a multi-unit imaging center. Conclusion Automated image quality analysis enables monitoring the performance of digital mammography systems in an efficient, centralized manner.

77 FR 63845 - Center for Scientific Review; Notice of Closed Meetings

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2012-10-17

... individuals associated with the grant applications, the disclosure of which would constitute a clearly...; Behavioral and Social Science Approaches to Preventing HIV/ AIDS Study Section. Date: November 8-9, 2012... Committee: Center for Scientific Review Special Emphasis Panel; Small Business: Cancer Diagnostics and...

75 FR 8371 - Center for Scientific Review; Notice of Closed Meetings

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2010-02-24

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78 FR 35292 - Center for Scientific Review; Notice of Closed Meetings

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2013-06-12

...: Functional Epigenomics: Developing Tools and Technologies for Manipulation of the Epigenome (R01). Date: July... Special Emphasis Panel; Member Conflict: Genome Integrity and Tumor Progression. Date: July 11, 2013. Time....gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict...

Seeking legitimacy for new assurance forms: The case of assurance on sustainability reporting

NARCIS (Netherlands)

O'Dwyer, B.; Owen, D.; Unerman, J.

2011-01-01

Based on the development of a more refined conception of legitimacy than has been used in prior audit/assurance and sustainability accounting research, this paper analyses how the legitimation processes adopted by sustainability assurance practitioners in a large professional services firm have

Central pathology review with two-stage quality assurance for pathological response after neoadjuvant chemotherapy in the ARTemis Trial.

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Thomas, Jeremy St John; Provenzano, Elena; Hiller, Louise; Dunn, Janet; Blenkinsop, Clare; Grybowicz, Louise; Vallier, Anne-Laure; Gounaris, Ioannis; Abraham, Jean; Hughes-Davies, Luke; McAdam, Karen; Chan, Stephen; Ahmad, Rizvana; Hickish, Tamas; Houston, Stephen; Rea, Daniel; Caldas, Carlos; Bartlett, John Ms; Cameron, David Allan; Hayward, Richard Laurence; Earl, Helena Margaret

2017-08-01

The ARTemis Trial tested standard neoadjuvant chemotherapy±bevacizumab in the treatment of HER2-negative early breast cancer. We compare data from central pathology review with report review and also the reporting behavior of the two central pathologists. Eight hundred women with HER2-negative early invasive breast cancer were recruited. Response to chemotherapy was assessed from local pathology reports for pathological complete response in breast and axillary lymph nodes. Sections from the original core biopsy and surgical excision were centrally reviewed by one of two trial pathologists blinded to the local pathology reports. Pathologists recorded response to chemotherapy descriptively and also calculated residual cancer burden. 10% of cases were double-reported to compare the central pathologists' reporting behavior. Full sample retrieval was obtained for 681 of the 781 patients (87%) who underwent surgery within the trial and were evaluable for pathological complete response. Four hundred and eighty-three (71%) were assessed by JSJT, and 198 (29%) were assessed by EP. Residual cancer burden calculations were possible in 587/681 (86%) of the centrally reviewed patients, as 94/681 (14%) had positive sentinel nodes removed before neoadjuvant chemotherapy invalidating residual cancer burden scoring. Good concordance was found between the two pathologists for residual cancer burden classes within the 65-patient quality assurance exercise (kappa 0.63 (95% CI: 0.57-0.69)). Similar results were obtained for the between-treatment arm comparison both from the report review and the central pathology review. For pathological complete response, report review was as good as central pathology review but for minimal residual disease, report review overestimated the extent of residual disease. In the ARTemis Trial central pathology review added little in the determination of pathological complete response but had a role in evaluating low levels of residual disease. Calculation

Center Variation and the Effect of Center and Provider Characteristics on Clinical Outcomes in Kidney Transplantation: A Systematic Review of the Evidence

Directory of Open Access Journals (Sweden)

Anne Tsampalieros

2017-10-01

Full Text Available Background: Kidney transplantation is the best treatment option for patients with end-stage renal disease. While patient-level factors affecting survival are established, the presence of variation in the management of transplant recipients remains unknown. Objective: The objective of this study was to examine center variation in kidney transplantation and identify center and provider characteristics that may be associated with clinical outcomes. Design: This is a systematic review. Data sources: Ovid Medline, Embase, and Cochrane library from inception to June 2016 were used. Study eligibility: Any study examining the association between center or provider characteristics and graft or patient survival, quality of life, or functional status were included. Results: We identified 6327 records and 24 studies met eligibility. Most studies used data registries. Characteristics evaluated include center volume (n = 17, provider volume (n = 2, provider experience (n = 1, center type (n = 2, and location of follow-up (n = 1. Outcomes assessed included graft survival (n = 24 and patient survival (n = 9. Significant center variation was described in 12 of 15 and 5 of 7 studies for graft and patient survival. There was a significant and positive association between center volume and graft and patient survival in 8 and 2 studies, respectively. Provider experience and volume were significantly associated with less allograft loss and provider volume with lower risk of death. There was no association between graft survival and location of follow-up or center type. Limitations: There was substantial heterogeneity in the variables assessed and methodology used to analyze associations. Conclusion: This systematic review found center variation in kidney transplantation. Future studies in the current era are necessary to better evaluate this important topic.

An automated electronic system for managing radiation treatment plan peer review reduces missed reviews at a large, high-volume academic center.

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Gabriel, Peter E; Woodhouse, Kristina D; Lin, Alexander; Finlay, Jarod C; Young, Richard B; Volz, Edna; Hahn, Stephen M; Metz, James M; Maity, Amit

Assuring quality in cancer care through peer review has become increasingly important in radiation oncology. In 2012, our department implemented an automated electronic system for managing radiation treatment plan peer review. The purpose of this study was to compare the overall impact of this electronic system to our previous manual, paper-based system. In an effort to improve management, an automated electronic system for case finding and documentation of review was developed and implemented. The rates of missed initial reviews, late reviews, and missed re-reviews were compared for the pre- versus postelectronic system cohorts using Pearson χ 2 test and relative risk. Major and minor changes or recommendations were documented and shared with the assigned clinical provider. The overall rate of missed reviews was 7.6% (38/500) before system implementation versus 0.4% (28/6985) under the electronic system (P automated system. Missed re-reviews occurred in 23.1% (3/13) of courses in the preelectronic system cohort and 6.6% (10/152) of courses in the postelectronic system cohort (P = .034). Late reviews were more frequent during high travel or major holiday periods. Major changes were recommended in 2.2% and 2.8% in the pre- versus postelectronic systems, respectively. Minor changes were recommended in 5.3% of all postelectronic cases. The implementation of an automated electronic system for managing peer review in a large, complex department was effective in significantly reducing the number of missed reviews and missed re-reviews when compared to our previous manual system. Copyright © 2016 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.

Economic implications of home births and birth centers: a structured review.

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Henderson, Jane; Petrou, Stavros

2008-06-01

It is widely perceived that home births and birth centers may help decrease the costs of maternity care for women with uncomplicated pregnancies and deliveries. This structured review examines the literature relating to the economic implications of home births and birth center care compared with hospital maternity care. The bibliographic databases MEDLINE (from 1950), CINAHL (from 1982), EMBASE (from 1980), and an "in-house" database, Econ2, were searched for relevant English language publications using MeSH and free text terms. Data were extracted with respect to the study design, inclusion criteria, clinical and cost results, and details of what was included in the cost calculations. Eleven studies were included from the United Kingdom, United States, Australia, and Canada. Two studies focused on home births versus other forms and locations of care, whereas nine focused on birth centers versus other forms and locations of care. Resource use was generally lower for women cared for at home and in birth centers due to lower rates of intervention, shorter lengths of stay, or both. However, this fact did not always translate into lower costs because, in the U.K. where many studies were conducted, more midwives of a higher grade were employed to manage the birth centers than are usually employed in maternity units, and because of costs of converting existing facilities into delivery rooms. The quality of much of the literature was poor, although no studies were excluded for this reason. Selection bias was likely to be a problem in those studies not based on randomized controlled trials because, even where birth center eligibility was applied throughout, women who choose to deliver at home or in a birth center are likely to be different in terms of expectations and approach from women choosing to deliver in hospital. This review highlights the paucity of economic literature relating to home births and birth centers. Differences in results between studies may be

Workshop on measurement quality assurance for ionizing radiation: Proceedings

Energy Technology Data Exchange (ETDEWEB)

Heath, J.A.; Swinth, K.L. [comps.

1993-12-31

This workshop was held to review the status of secondary level calibration accreditation programs, review related measurement accreditation programs, document lessons learned, and to present changes in programs due to new national priorities involving radioactivity measurements. Contents include: fundamentals of measurement quality assurance (MQA), standards for MQA programs; perspectives and policies; complete MQA programs; future MQA programs; QA/QC programs--radioactivity; QA/QC programs--dosimetry; laboratory procedures for QA/QC; in-house control of reference dosimetry laboratories; in-house controls of radioactivity laboratories; and poster session. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

Workshop on measurement quality assurance for ionizing radiation: Proceedings

International Nuclear Information System (INIS)

Heath, J.A.; Swinth, K.L.

1993-01-01

This workshop was held to review the status of secondary level calibration accreditation programs, review related measurement accreditation programs, document lessons learned, and to present changes in programs due to new national priorities involving radioactivity measurements. Contents include: fundamentals of measurement quality assurance (MQA), standards for MQA programs; perspectives and policies; complete MQA programs; future MQA programs; QA/QC programs--radioactivity; QA/QC programs--dosimetry; laboratory procedures for QA/QC; in-house control of reference dosimetry laboratories; in-house controls of radioactivity laboratories; and poster session. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database

The Royal College of Pathologists of Australasia Quality Assurance Program: Immunohistochemistry Breast Marker Audit Overview 2005-2015.

Science.gov (United States)

Haffajee, Zenobia Ayesha Mohamed; Kumar, Beena; Francis, Glenn; Peck, Martyn; Badrick, Tony

2017-11-20

The Royal College of Pathologists of Australasia Quality Assurance Program (RCPAQAP) Anatomical Pathology provides a comprehensive External Quality Assurance (EQA) exercise to review the reporting of immunohistochemistry (IHC) and in-situ hybridization (ISH) breast markers through an audit of clinical results. The aim of this exercise was to provide information regarding the quality of breast marker testing within clinical laboratories from 2005 to 2015. This comprehensive audit included estrogen, progesterone, and HER2 marker reporting. This was an important quality assurance activity established in response to ongoing difficulties experienced in laboratories in this area of testing.

42 CFR 422.210 - Assurances to CMS.

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2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Assurances to CMS. 422.210 Section 422.210 Public...) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Relationships With Providers § 422.210 Assurances to CMS. (a) Assurances to CMS. Each organization will provide assurance satisfactory to the Secretary that the...

40 CFR 31.45 - Quality assurance.

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2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Quality assurance. 31.45 Section 31.45... Requirements Reports, Records, Retention, and Enforcement § 31.45 Quality assurance. If the grantee's project... quality assurance practices consisting of policies, procedures, specifications, standards, and...

78 FR 3904 - Center for Scientific Review; Notice of Closed Meetings

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2013-01-17

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78 FR 5466 - Center for Scientific Review; Notice of Closed Meetings

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