Evaluation of the acidity constants of the 4-hidroxy-5-6salicylideneamino9-2-7-naphthalenedisulfonic acid (Azomethine-H) using UV?vis spectrophotometry

Science.gov (United States)

Alarcón-Angeles, G.; Corona-Avendaño, S.; Rojas-Hernández, A.; Romero-Romo, M. A.; Ramírez-Silva, M. T.

2005-01-01

The time stability of the azomethine-H species was determined not to be better than 10 min in the absence of oxygen and light, however under phosphate buffered conditions the azomethine-H species remained stable for longer periods, as indicated by the spectrophotometric behaviour. Nevertheless, the analysis time still exceeded the stability allowance. Therefore, the determination of the acidity constants of the Azomethine-H species was studied by means of UV-vis spectrophotometry in buffered media by means of the point-by-point analysis and data processing with SQUAD to refine the resulting constants, which were: p Ka1=3.39, p Ka2 7.36 and p Ka3 8.73. The latter were associated to the corresponding acid-base equilibria of the amine and hydroxy groups constituting the molecule.

Challenges in pKa Predictions for Proteins: The case of Asp213 in Human Proteinase 3

Science.gov (United States)

Hajjar, Eric; Dejaegere, Annick; Reuter, Nathalie

2009-09-01

Knowledge of the protonation states of the ionizable residues in an enzyme is a prerequisite to an accurate description of its structure and mechanism. In practice, the use of the inappropriate protonation state for an amino acid in a molecular modeling computation (e.g., molecular dynamics simulation) is likely to lead to unrealistic results. Although methods using solvers of the linearized Poisson-Boltzmann equation have proven to yield accurate pKa predictions, they bear a number of limitations. They are quite demanding in terms of computational power and are sensitive to representation of the charges and their position (force field and protein conformation). Moreover they depend on the choice of a dielectric constant for the protein interior. In this manuscript, we describe the difficulties met when trying to predict the protonation state of a buried amino acid, located in a protein for which very little biochemical data is available. Such a case is highly representative of the challenges faced in theoretical biology studies. Proteinase 3 (PR3) is an enzyme involved in proteolytic events associated with inflammation. It is a potential target in the development of new anti-inflammatory therapeutic strategies. We report the results of pKa predictions of the aspartic acid 213 of PR3 with a FDPB solver. We probed the influence of the choice of the dielectric constant for the protein interior ɛp and the benefits of conformational sampling by molecular dynamics (MD) on the pKa prediction of this carboxylate group. Using only the FDPB calculations, we could not conclude on the protonation state of Asp213. MD simulations confronted to knowledge of the ligand-binding and reaction mechanism led us to decide on a protonated form of this aspartic acid. We also demonstrate that the use of the wrong protonation state leads to an unreliable structural model for PR3. pKa prediction with a fast empirical method yielded a pKa of 8.4 for Asp213, which is in agreement with our

The thermodynamic dissociation constants of losartan, paracetamol, phenylephrine and quinine by the regression analysis of spectrophotometric data

International Nuclear Information System (INIS)

Meloun, Milan; Syrovy, Tomas; Vrana, Ales

2005-01-01

The mixed dissociation constants of four drug acids - losartan, paracetamol, phenylephrine and quinine - at various ionic strengths I of range 0.01 and 1.0 and at temperatures of 25 and 37 deg. C were determined using SPECFIT32 and SQUAD(84) regression analysis of the pH-spectrophotometric titration data. A proposed strategy of efficient experimentation in a dissociation constants determination, followed by a computational strategy for the chemical model with a dissociation constants determination, is presented on the protonation equilibria of losartan. Indices of precise methods predict the correct number of components, and even the presence of minor ones when the data quality is high and the instrumental error is known. Improved identification of the number of species uses the second or third derivative function for some indices, namely when the number of species in the mixture is higher than 3 and when, due to large variations in the indicator values even at logarithmic scale, the indicator curve does not reach an obvious point where the slope changes. The thermodynamic dissociation constant pKaT was estimated by nonlinear regression of {pK a , I} data at 25 and 37 deg. C: for losartan pKa,1T=3.63(1) and 3.57(3), pKa,2T=4.84(1) and 4.80(3), for paracetamol pKa,1T=9.78(1) and 9.65(1), for phenylephrine pKa,1T=9.17(1) and 8.95(1), pKa,2T=10.45(1) and 10.22(1), for quinine pKa,1T=4.25(1) and 4.12(1), pKa,2T=8.72(1) and 8.46(2). Goodness-of-fit tests for various regression diagnostics enabled the reliability of the parameter estimates to be found

The thermodynamic dissociation constants of losartan, paracetamol, phenylephrine and quinine by the regression analysis of spectrophotometric data

Energy Technology Data Exchange (ETDEWEB)

Meloun, Milan [Department of Analytical Chemistry, University of Pardubice, 53210 Pardubice (Czech Republic)]. E-mail: milan.meloun@upce.cz; Syrovy, Tomas [Department of Analytical Chemistry, University of Pardubice, 53210 Pardubice (Czech Republic)]. E-mail: tomas.syrovy@upce.cz; Vrana, Ales [IVAX Pharmaceuticals, s.r.o. 74770 Opava (Czech Republic)]. E-mail: ales_vrana@ivax-cr.com

2005-03-21

The mixed dissociation constants of four drug acids - losartan, paracetamol, phenylephrine and quinine - at various ionic strengths I of range 0.01 and 1.0 and at temperatures of 25 and 37 deg. C were determined using SPECFIT32 and SQUAD(84) regression analysis of the pH-spectrophotometric titration data. A proposed strategy of efficient experimentation in a dissociation constants determination, followed by a computational strategy for the chemical model with a dissociation constants determination, is presented on the protonation equilibria of losartan. Indices of precise methods predict the correct number of components, and even the presence of minor ones when the data quality is high and the instrumental error is known. Improved identification of the number of species uses the second or third derivative function for some indices, namely when the number of species in the mixture is higher than 3 and when, due to large variations in the indicator values even at logarithmic scale, the indicator curve does not reach an obvious point where the slope changes. The thermodynamic dissociation constant pKaT was estimated by nonlinear regression of {l_brace}pK{sub a}, I{r_brace} data at 25 and 37 deg. C: for losartan pKa,1T=3.63(1) and 3.57(3), pKa,2T=4.84(1) and 4.80(3), for paracetamol pKa,1T=9.78(1) and 9.65(1), for phenylephrine pKa,1T=9.17(1) and 8.95(1), pKa,2T=10.45(1) and 10.22(1), for quinine pKa,1T=4.25(1) and 4.12(1), pKa,2T=8.72(1) and 8.46(2). Goodness-of-fit tests for various regression diagnostics enabled the reliability of the parameter estimates to be found.

On the development of protein pKa calculation algorithms

Science.gov (United States)

Carstensen, Tommy; Farrell, Damien; Huang, Yong; Baker, Nathan A.; Nielsen, Jens Erik

2011-01-01

Protein pKa calculation methods are developed partly to provide fast non-experimental estimates of the ionization constants of protein side chains. However, the most significant reason for developing such methods is that a good pKa calculation method is presumed to provide an accurate physical model of protein electrostatics, which can be applied in methods for drug design, protein design and other structure-based energy calculation methods. We explore the validity of this presumption by simulating the development of a pKa calculation method using artificial experimental data derived from a human-defined physical reality. We examine the ability of an RMSD-guided development protocol to retrieve the correct (artificial) physical reality and find that a rugged optimization landscape and a huge parameter space prevent the identification of the correct physical reality. We examine the importance of the training set in developing pKa calculation methods and investigate the effect of experimental noise on our ability to identify the correct physical reality, and find that both effects have a significant and detrimental impact on the physical reality of the optimal model identified. Our findings are of relevance to all structure-based methods for protein energy calculations and simulation, and have large implications for all types of current pKa calculation methods. Our analysis furthermore suggests that careful and extensive validation on many types of experimental data can go some way in making current models more realistic. PMID:21744393

Millennial-scale variations in dustiness recorded in Mid-Atlantic sediments from 0 to 70 ka

Science.gov (United States)

Middleton, Jennifer L.; Mukhopadhyay, Sujoy; Langmuir, Charles H.; McManus, Jerry F.; Huybers, Peter J.

2018-01-01

Sedimentary records of dust deposition in the subtropical Atlantic provide important constraints on millennial- and orbital-scale variability in atmospheric circulation and North African aridity. Constant flux proxies, such as extraterrestrial helium-3, yield dust flux records that are independent of the biases caused by lateral sediment transport and limited resolution that may be associated with age-model-derived mass accumulation rates. However, Atlantic dust records constrained using constant flux proxies are sparsely distributed and generally limited to the past 20 ka. Here we extend the Atlantic record of North African dust deposition to 70 ka using extraterrestrial helium-3 and measurements of titanium, thorium, and terrigenous helium-4 in two sediment cores collected at 26°N and 29°N on the Mid-Atlantic Ridge and compare results to model estimates for dust deposition in the subtropical North Atlantic. Dust proxy fluxes between 26°N and 29°N are well correlated, despite variability in lateral sediment transport, and underscore the utility of extraterrestrial helium-3 for constraining millennial-scale variability in dust deposition. Similarities between Mid-Atlantic dust flux trends and those observed along the Northwest African margin corroborate previous interpretations of dust flux variability over the past 20 ka and suggest that long distance transport and depositional processes do not overly obscure the signal of North African dust emissions. The 70 ka Mid-Atlantic record reveals a slight increase in North African dustiness from Marine Isotope Stage 4 through the Last Glacial Maximum and a dramatic decrease in dustiness associated with the African Humid Period. On the millennial-scale, the new records exhibit brief dust maxima coincident with North Atlantic cold periods such as the Younger Dryas, and multiple Heinrich Stadials. The correlation between Mid-Atlantic dust fluxes and previous constraints on North African aridity is high. However

Computational chemical analysis of unconjugated bilirubin anions and insights into pKa values clarification

Science.gov (United States)

Vega-Hissi, Esteban G.; Estrada, Mario R.; Lavecchia, Martín J.; Pis Diez, Reinaldo

2013-01-01

The pKa, the negative logarithm of the acid dissociation equilibrium constant, of the carboxylic acid groups of unconjugated bilirubin in water is a discussed issue because there are quite different experimental values reported. Using quantum mechanical calculations we have studied the conformational behavior of unconjugated bilirubin species (in gas phase and in solution modeled implicitly and explicitly) to provide evidence that may clarify pKa values because of its pathophysiological relevance. Our results show that rotation of carboxylate group, which is not restricted, settles it in a suitable place to establish stronger interactions that stabilizes the monoanion and the dianion to be properly solvated, demonstrating that the rationalization used to justify the high pKa values of unconjugated bilirubin is inappropriate. Furthermore, low unconjugated bilirubin (UCB) pKa values were estimated from a linear regression analysis.

Prediction of acid dissociation constants of organic compounds using group contribution methods

DEFF Research Database (Denmark)

Zhou, Teng; Jhamb, Spardha; Liang, Xiaodong

2018-01-01

data-points with average absolute error of 0.23; (b) a non-linear GC model for organic compounds using 1622 data-points with average absolute error of 1.18; (c) an artificial neural network (ANN) based GC model for the organic compounds with average absolute error of 0.17. For each of the developed......In this paper, group contribution (GC) property models for the estimation of acid dissociation constants (Ka) of organic compounds are presented. Three GC models are developed to predict the negative logarithm of the acid dissociation constant pKa: (a) a linear GC model for amino acids using 180...

Profiles of equilibrium constants for self-association of aromatic molecules.

Science.gov (United States)

Beshnova, Daria A; Lantushenko, Anastasia O; Davies, David B; Evstigneev, Maxim P

2009-04-28

Analysis of the noncovalent, noncooperative self-association of identical aromatic molecules assumes that the equilibrium self-association constants are either independent of the number of molecules (the EK-model) or change progressively with increasing aggregation (the AK-model). The dependence of the self-association constant on the number of molecules in the aggregate (i.e., the profile of the equilibrium constant) was empirically derived in the AK-model but, in order to provide some physical understanding of the profile, it is proposed that the sources for attenuation of the equilibrium constant are the loss of translational and rotational degrees of freedom, the ordering of molecules in the aggregates and the electrostatic contribution (for charged units). Expressions are derived for the profiles of the equilibrium constants for both neutral and charged molecules. Although the EK-model has been widely used in the analysis of experimental data, it is shown in this work that the derived equilibrium constant, K(EK), depends on the concentration range used and hence, on the experimental method employed. The relationship has also been demonstrated between the equilibrium constant K(EK) and the real dimerization constant, K(D), which shows that the value of K(EK) is always lower than K(D).

New insights on water level variability for Lake Turkana for the past 15 ka and at 150 ka from relict beaches

Science.gov (United States)

Forman, S. L.; Wright, D.

2015-12-01

Relict beaches adjacent to Lake Turkana provide a record of water level variability for the Late Quaternary. This study focused on deciphering the geomorphology, sedimentology, stratigraphy and 14C chronology of strand plain sequences in the Kalokol and Lothagam areas. Nine >30 m oscillations in water level were documented between ca. 15 and 4 ka. The earliest oscillation between ca. 14.5 and 13 ka is not well constrained with water level to at least 70 m above the present surface and subsequently fell to at least 50 m. Lake level increased to ~ 90 m between ca. 11.2 and 10.4 ka, post Younger Dryas cooling. Water level fell by >30 m by 10.2 ka, with another potential rise at ca. 8.5 ka to >70 m above current level. Lake level regressed by > 40 m at 8.2 ka coincident with cooling in the equatorial Eastern Atlantic Ocean. Two major >70 m lake level oscillations centered at 6.6 and 5.2 ka may reflect enhanced convection with warmer sea surface temperatures in the Western Indian Ocean. The end of the African Humid Period occurred from ca. 8.0 to 4.5 ka and was characterized by variable lake level (± > 40 m), rather than one monotonic fall in water level. This lake level variability reflects a complex response to variations in the extent and intensity of the East and West African Monsoons near geographic and topographic limits within the catchment of Lake Turkana. Also, for this closed lake basin excess and deficits in water input are amplified with a cascading lake effect in the East Rift Valley and through the Chew Bahir Basin. The final regression from a high stand of > 90 m began at. 5.2 ka and water level was below 20 m by 4.5 ka; and for the remainder of the Holocene. This sustained low stand is associated with weakening of the West African Monsoon, a shift of the mean position of Congo Air Boundary west of the Lake Turkana catchment and with meter-scale variability in lake level linked to Walker circulation across the Indian Ocean. A surprising observation is

Predicting the pKa and stability of organic acids and bases at an oil-water interface

DEFF Research Database (Denmark)

Andersson, Martin Peter; Olsson, Mats Henrik Mikael; Stipp, Susan Louise Svane

2014-01-01

We have used density functional theory and the implicit solvent model, COSMO-RS, to investigate how the acidity constant, pKa, of organic acids and bases adsorbed at the organic compound-aqueous solution interface changes, compared to its value in the aqueous phase. The pKa determine the surface...... phase and the rest remains in the hydrophilic phase. We found that the pKa for acids is shifted by ∼1 pH unit to higher values compared to the bulk water pKa, whereas they are shifted to lower values by a similar amount for bases. Because this pKa shift is similar in magnitude for each of the molecules...... is not the same as in the bulk. For example, species such as carboxylic acids are enriched at the interface, where they can dominate surface properties, even when they are a modest component in the bulk fluid. For high surface concentrations of carboxylic acid groups at an interface, such as a self...

Development of a 20kA current feedthrough using YBCO bulk conductors

International Nuclear Information System (INIS)

Maehata, Keisuke; Ishibashi, Kenji; Shintomi, Takakazu; Iwamoto, Akifumi; Maekawa, Ryuji; Mito, Toshiyuki

2004-01-01

In the phase II experiment of the Large Helical Device (LHD) of the National Institute for Fusion Science (NIFS), it is planned to operate the helical coils at 1.8 K by employing pressurized superfluid cooling to raise the magnetic field to 4 T with 17.3 kA. It is important to develop a 20kA-class current feedthrough into the 1.8 K region, but it must have a high current capacity and low heat leakage in the maximum magnetic leakage field of 1 T. Rectangle-shaped YBCO bulk conductors measuring 20 mm wide, 140 mm long and 10 mm thick were manufactured from square-pillar-shaped YBCO bulk materials for a 20 kA current. To check the quality of the bulk conductors, internal defects or cracks were detected by carrying out a precise survey of trapped magnetic flux. An assembled 20 kA current feedthrough was mounted in the λ-plate of a pressurized superfluid cooling cryostat. Experiments of current feeding into the 1.8 K region were carried out by operating the 20 kA current feedthrough. In the experiments, the transport current was kept at 20 kA for longer than 1,200 s. During the 20 kA operation, the current transport section of the YBCO bulk conductors remained in the superconducting state and the voltage drop between the YBCO bulk conductors and the copper electrode was observed to be constant. A contact resistance and the Joule heat generation in the joint region between the YBCO bulk conductors and the copper electrode were obtained as 1.45 nΩ and 0.72 W, respectively in the 20 kA operation. We have demonstrated the feasibility of using a 20 kA current feedthrough for the phase II experiment of the LHD. (author)

Analysis of agonist dissociation constants as assessed by functional antagonism in guinea pig left atria

International Nuclear Information System (INIS)

Molenaar, P.; Malta, E.

1986-01-01

In electrically driven guinea pig left atria, positive inotropic responses to (-)-isoprenaline and the selective beta 1-adrenoceptor agonist RO363 were obtained in the absence and in the presence of the functional antagonists adenosine, carbachol, gallopamil, nifedipine, and Ro 03-7894. Each of the functional antagonists reduced the maximum response to both agonists and produced nonparallel rightward shifts in the cumulative concentration effect curves. For both agonists, dissociation constants (KA) were calculated using the equation described by Furchgott (1966) for irreversible antagonism. For RO363, which is a partial agonist with high agonist activity, the equations outlined for functional interaction by Mackay (1981) were also employed to calculate KA values. The KA values obtained by each method were compared with the dissociation constants (KD) for the two agonists determined from their ability to displace the radioligand (-)-[ 125 I]iodocyanopindolol from beta 1-adrenoceptors in guinea pig left atrial membrane preparations. The estimates of KA varied substantially from KD values. The KD values were taken as more accurate estimates of the true values for the dissociation constants because a high degree of correlation exists between pKD and pD2 values for a number of other beta-adrenoceptor agonists that behave as partial agonists and between pKD and pKB values for a number of beta-adrenoceptor antagonists. Thus, it appears that there are serious limitations in the current theory for using functional antagonism as a means of obtaining agonist dissociation constants

Ionization and thermodynamic constants of 6-methylquinoline by potentiometry in aqueous and mixed organic-water solvent systems

International Nuclear Information System (INIS)

Hafiz, A; Indhar, B.; Khanzada, A.W.K.

2000-01-01

The ionization constant pKa and Gibbs's free energy DG of 6-methylquinoline are determined in aqueous solution at different temperatures and in three mixed organic-water solvent systems at 25 deg. C. It is observed that dissociation constant of 6-methylquinoline in aqueous system decreases with the increase of temperature. The curve is a parabolic. It is noted that pKa values of this compound are higher than those of quinoline and 8-methylquinoline. In case of mixed organic-water solvent systems, the influence of these solvents on the ionization equilibria of NH/sub 2/ group has been observed. The pK M/A and pK T/A values versus percent composition decrease gradually with increase in percent of organic solvents The curve of the pK/sub a/ versus percent composition is a distorted parabola. The data have been obtained potentiometrically by titrating 6-methylquinoline solutions with HCl. The values of dissociation constant were obtained from these data by a computer program written in GW-BASIC. From pKa values Gibbs's free energies DG for the respective pKa values have also been calculated. (author)

Experimental determination of monoethanolamine protonation constant and its temperature dependency

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Ma’mun Sholeh

2017-01-01

Full Text Available Carbon dioxide as one of the major contributors to the global warming problem is produced in large quantities by many important industries and its emission seems to rise from year to year. Aminebased absorption is one of the methods to capture CO2 from its sources. As a reactive system, mass transfer and chemical reaction take place simultaneously. In a vapor-liquid equilibrium model for the CO2-amine-water system, some parameters such as mass transfer coefficients and chemical equilibrium constants need to be known. However, some parameters could be determined experimentally and the rests could be regressed from the model. The protonation constant (pKa, as one of the model parameters, could then be measured experimentally. The purpose of this study is to measure the pKa of monoethanolamine (MEA at a range of temperatures from 303 to 330K by a potentiometric titration method. The experimental data obtained were in a good agreement with the literature data. The pKa data from this work together with those from the literature were then correlated in an empirical correlation to be used for future research.

Comparing the Titrations of Mixed-Acid Solutions Using Dropwise and Constant-Flow Techniques

Science.gov (United States)

Charlesworth, Paul; Seguin, Matthew J.; Chesney, David J.

2003-11-01

A mixed-acid solution containing hydrochloric and phosphoric acids was used to determine the error associated with performing a real-time titration. The results were compared against those obtained by performing the titration in a more traditional dropwise addition of titrant near the equivalence points. It was found that the real-time techniques resulted in significantly decreased analysis times while maintaining a low experimental error. The constant-flow techniques were implemented into two different levels of chemistry. It was found that students could successfully utilize the modified experiments. Problems associated with the techniques, major sources of error, and their solutions are discussed. In both cases, the use of the constant-flow setup has increased student recollection of key concepts, such as pKa determination, proper indicator choice, and recognizing the shape of specific titration curves by increasing student interest in the experiment.

pKa values in proteins determined by electrostatics applied to molecular dynamics trajectories.

Science.gov (United States)

Meyer, Tim; Knapp, Ernst-Walter

2015-06-09

For a benchmark set of 194 measured pKa values in 13 proteins, electrostatic energy computations are performed in which pKa values are computed by solving the Poisson-Boltzmann equation. In contrast to the previous approach of Karlsberg(+) (KB(+)) that essentially used protein crystal structures with variations in their side chain conformations, the present approach (KB2(+)MD) uses protein conformations from four molecular dynamics (MD) simulations of 10 ns each. These MD simulations are performed with different specific but fixed protonation patterns, selected to sample the conformational space for the different protonation patterns faithfully. The root-mean-square deviation between computed and measured pKa values (pKa RMSD) is shown to be reduced from 1.17 pH units using KB(+) to 0.96 pH units using KB2(+)MD. The pKa RMSD can be further reduced to 0.79 pH units, if each conformation is energy-minimized with a dielectric constant of εmin = 4 prior to calculating the electrostatic energy. The electrostatic energy expressions upon which the computations are based have been reformulated such that they do not involve terms that mix protein and solvent environment contributions and no thermodynamic cycle is needed. As a consequence, conformations of the titratable residues can be treated independently in the protein and solvent environments. In addition, the energy terms used here avoid the so-called intrinsic pKa and can therefore be interpreted without reference to arbitrary protonation states and conformations.

Determination of acid dissociation constants of warfarin and hydroxywarfarins by capillary electrophoresis.

Science.gov (United States)

Nowak, Paweł; Olechowska, Paulina; Mitoraj, Mariusz; Woźniakiewicz, Michał; Kościelniak, Paweł

2015-08-10

In this work the acid dissociation constants--pKa of warfarin and its all important oxidative metabolites have been determined by capillary electrophoresis-based methods. It has resulted in a complete description of two acid-base dissociation equilibria, yet not investigated experimentally for phase I metabolites of warfarin. The capillary electrophoresis (CE) method based on the relation between effective electrophoretic mobilities and pH has proven to be a suitable tool for pKa determination, while the spectrophotometric (CE-DAD) and the internal standard methods (IS-CE), have appeared to be promising alternative approaches. The CE-DAD approach based on the change in absorbance spectra between the acidic and basic forms is a combination between capillary electrophoresis and spectrophotometric titration, and yields very consistent values of pKa1 with CE. The IS-CE, in turn, enables an estimation of pKa1 and pKa2 from only two analytical runs, however, less accurate than CE and CE-DAD. The Debye-Hückel model has been confirmed experimentally as a good predictor of pKa values at various ionic strengths. Therefore, it has been used in determination of thermodynamic pKa1 and pKa2, referring to the zero ionic strength. The results are important from the analytical, pharmacological, and theoretical points of view. Copyright © 2015 Elsevier B.V. All rights reserved.

Bohorodyts'ka and Starosamars'ka hundred (sotnya: administrative system and officer (starshyna corps

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Repan, O. A.

2017-12-01

Full Text Available Bohorodyts'ka and Starosamars'ka hundred (sotnyais an unique Cossack formations. They existed in a territorial isolation from the Hetmanate and Slobozhanshchyna, on the lands of the Zaporozhian Sich. The study of these formations will better understand the policy of the Russian government in relation to the Sich, to find out the methods by which the state authorities planned to put Zaporizhzhya Cossacks under their control. We do not know when the Bohorodyts'ka hundred (sotnya arose. Now the first mention in the documents dates back to 1700. The Russian government planned to create a Cossack regiment (polk here, but in reality was founded a Cossack hundred (sotnya. Ivan Mazepa, as an autonomous ruler, wanted to include this formation in the structure of Hetmanate, but a hundred (sotnya was subject to the authority of a representative of the Russian administration – the Kiev governor. The hundreds (sotnya were liquidated as a result of Russia's defeat in the war with Turkey and the signing of the Prut peace in 1711. We do not know when the Cossack hundred (sotnya was restored under the name Starosamars'ka. This happened in the late 1730s – early 1740s. In 1744, the Starosamarsʼka hundreds became part of the Poltava regiment (polk of the Hetmanate. The administrative apparatus of the hundreds was predominantly similar to other hundreds of Hetmanates, but the real power of the Cossack officers was a bit lower here. During the existence of the Starosamars'ka hundreds, such a body of self-government was preserved as a council (rada that was not typical for the Hetmanate in this period. This was due to the fact that the peoples could easily escape from their power and move to neighboring settlements and recognize the jurisdiction of the Zaporozhska Sich. The population of hundreds and officers consisted mainly of immigrants from the left bank of the Dnieper, to a lesser extent – from immigrants from the right bank. Summing up, I note that the

Residues in the H+ Translocation Site Define the pKa for Sugar Binding to LacY†

Science.gov (United States)

Smirnova, Irina; Kasho, Vladimir; Sugihara, Junichi; Choe, Jun-Yong; Kaback, H. Ronald

2009-01-01

A remarkably high pKa of approximately 10.5 has been determined for sugar-binding affinity to the lactose permease of Escherichia coli (LacY), indicating that, under physiological conditions, substrate binds to fully protonated LacY. We have now systematically tested site-directed replacements for the residues involved in sugar binding, as well as H+ translocation and coupling, in order to determine which residues may be responsible for this alkaline pKa. Mutations in the sugar-binding site (Glu126, Trp151, Glu269) markedly decrease affinity for sugar but do not alter the pKa for binding. In contrast, replacements for residues involved in H+ translocation (Arg302, Tyr236, His322, Asp240, Glu325, Lys319) exhibit pKa values for sugar binding that are either shifted toward neutral pH or independent of pH. Values for the apparent dissociation constant for sugar binding (Kdapp) increase greatly for all mutants except neutral replacements for Glu325 or Lys319, which are characterized by remarkably high affinity sugar binding (i.e., low Kdapp) from pH 5.5 to pH 11. The pH dependence of the on- and off-rate constants for sugar binding measured directly by stopped-flow fluorometry implicates koff as a major factor for the affinity change at alkaline pH and confirms the effects of pH on Kdapp inferred from steady-state fluorometry. These results indicate that the high pKa for sugar binding by wild-type LacY cannot be ascribed to any single amino acid residue but appears to reside within a complex of residues involved in H+ translocation. There is structural evidence for water bound in this complex, and the water could be the site of protonation responsible for the pH dependence of sugar binding. PMID:19689129

Predicting the pKa and stability of organic acids and bases at an oil-water interface.

Science.gov (United States)

Andersson, M P; Olsson, M H M; Stipp, S L S

2014-06-10

We have used density functional theory and the implicit solvent model, COSMO-RS, to investigate how the acidity constant, pKa, of organic acids and bases adsorbed at the organic compound-aqueous solution interface changes, compared to its value in the aqueous phase. The pKa determine the surface charge density of the molecules that accumulate at the fluid-fluid interface. We have estimated the pKa by comparing the stability of the protonated and unprotonated forms of a series of molecules in the bulk aqueous solution and at an interface where parts of each molecule reside in the hydrophobic phase and the rest remains in the hydrophilic phase. We found that the pKa for acids is shifted by ∼1 pH unit to higher values compared to the bulk water pKa, whereas they are shifted to lower values by a similar amount for bases. Because this pKa shift is similar in magnitude for each of the molecules studied, we propose that the pKa for molecules at a water-organic compound interface can easily be predicted by adding a small shift to the aqueous pKa. This shift is general and correlates with the functional group. We also found that the relative composition of molecules at the fluid-fluid interface is not the same as in the bulk. For example, species such as carboxylic acids are enriched at the interface, where they can dominate surface properties, even when they are a modest component in the bulk fluid. For high surface concentrations of carboxylic acid groups at an interface, such as a self-assembled monolayer, we have demonstrated that the pKa depends on the degree of deprotonation through direct hydrogen bonding between protonated and deprotonated acidic headgroups.

Effects of alkyl chain length and solvents on thermodynamic dissociation constants of the ionic liquids with one carboxyl group in the alkyl chain of imidazolium cations.

Science.gov (United States)

Chen, Yuehua; Wang, Huiyong; Wang, Jianji

2014-05-01

Thermodynamic dissociation constants of the Brønsted acidic ionic liquids (ILs) are important for their catalytic and separation applications. In this work, a series of imidazolium bromides with one carboxylic acid substitute group in their alkyl chain ([{(CH2)nCOOH}mim]Br, n = 1,3,5,7) have been synthesized, and their dissociation constants (pKa) at different ionic strengths have been determined in aqueous and aqueous organic solvents at 0.1 mole fraction (x) of ethanol, glycol, iso-propanol, and dimethyl sulfoxide by potentiometric titrations at 298.2 K. The standard thermodynamic dissociation constants (pKa(T)) of the ILs in these solvents were calculated from the extended Debye-Hückel equation. It was found that the pKa values increased with the increase of ionic strength of the media and of the addition of organic solvent in water. The pKa(T) values also increased with the increase of the alkyl chain length of cations of the ILs. In addition, the effect of solvent nature on pKa(T) values is interpreted from solvation of the dissociation components and their Gibbs energy of transfer from water to aqueous organic solutions.

Deep-Space Ka-Band Flight Experience

Science.gov (United States)

Morabito, D. D.

2017-11-01

Lower frequency bands have become more congested in allocated bandwidth as there is increased competition between flight projects and other entities. Going to higher frequency bands offers significantly more bandwidth, allowing for the use of much higher data rates. However, Ka-band is more susceptible to weather effects than lower frequency bands currently used for most standard downlink telemetry operations. Future or prospective flight projects considering deep-space Ka-band (32-GHz) telemetry data links have expressed an interest in understanding past flight experience with received Ka-band downlink performance. Especially important to these flight projects is gaining a better understanding of weather effects from the experience of current or past missions that operated Ka-band radio systems. We will discuss the historical flight experience of several Ka-band missions starting from Mars Observer in 1993 up to present-day deep-space missions such as Kepler. The study of historical Ka-band flight experience allows one to recommend margin policy for future missions. Of particular interest, we will review previously reported-on flight experience with the Cassini spacecraft Ka-band radio system that has been used for radio science investigations as well as engineering studies from 2004 to 2015, when Cassini was in orbit around the planet Saturn. In this article, we will focus primarily on the Kepler spacecraft Ka-band link, which has been used for operational telemetry downlink from an Earth trailing orbit where the spacecraft resides. We analyzed the received Ka-band signal level data in order to characterize link performance over a wide range of weather conditions and as a function of elevation angle. Based on this analysis of Kepler and Cassini flight data, we found that a 4-dB margin with respect to adverse conditions ensures that we achieve at least a 95 percent data return.

Ferroelectric switch for a high-power Ka-band active pulse compressor

Energy Technology Data Exchange (ETDEWEB)

Hirshfield, Jay L. [Omega-P, Inc., New Haven, CT (United States)

2013-12-18

Results are presented for design of a high-power microwave switch for operation at 34.3 GHz, intended for use in an active RF pulse compressor. The active element in the switch is a ring of ferroelectric material, whose dielectric constant can be rapidly changed by application of a high-voltage pulse. As envisioned, two of these switches would be built into a pair of delay lines, as in SLED-II at SLAC, so as to allow 30-MW μs-length Ka-band pulses to be compressed in time by a factor-of-9 and multiplied in amplitude to generate 200 MW peak power pulses. Such high-power pulses could be used for testing and evaluation of high-gradient mm-wave accelerator structures, for example. Evaluation of the switch design was carried out with an X-band (11.43 GHz) prototype, built to incorporate all the features required for the Ka-band version.

The Determination of "Apparent" pKa's. Part II: An Experiment Using Very Weak Acids (pKa's > 11.4).

Science.gov (United States)

Cawley, John J.

1995-01-01

Presents an experiment designed to show students that the Henderson-Hasselbalch equation will fail when they use this particular one-half titration technique for acids with large pKa's. Involves determining the apparent pKa for such acids and using that to calculate the true pKa. (JRH)

Fade Mitigation Techniques at Ka-Band

Science.gov (United States)

Dissanayake, Asoka (Editor)

1996-01-01

Rain fading is the dominant propagation impairment affecting Ka-band satellite links and rain fade mitigation is a key element in the design of Ka-band satellite networks. Some of the common fade mitigation techniques include: power control, diversity, adaptive coding, and resource sharing. The Advanced Communications Technology Satellite (ACTS) provides an excellent opportunity to develop and test Ka-band rain impairment amelioration techniques. Up-link power control and diversity are discussed in this paper.

Theoretical study (ab initio and DFT methods on acidic dissociation constant of xylenol orange in aqueous solution

Directory of Open Access Journals (Sweden)

F. Kiani

2017-07-01

Full Text Available Analytical measurement of materials requires exact knowledge of their acid dissociation constant (pKa values. In recent years, quantum mechanical calculations have been extensively used to study of acidities in the aqueous solutions and the results were compared with the experimental values. In this study, a theoretical study was carried out on xylenol orange (in water solution by ab initio method. We calculated the pKa values of xylenol orange in water, using high-level ab initio (PM3, DFT (HF, B3LYP/6-31+G(d and SCRF methods. The experimental determination of these values (pKa,s is a challenge because xylenol orange has a low solubility in water. We considered several ionization reactions and equilibriums in water that constitute the indispensable theoretical basis to calculate the pKa values of xylenol orange. The results show that the calculated pKa values have a comparable agreement with the experimentally determined pKa values. Therefore, this method can be used to predict such properties for indicators, drugs and other important molecules.

Photometric method for determination of acidity constants through integral spectra analysis

Science.gov (United States)

Zevatskiy, Yuriy Eduardovich; Ruzanov, Daniil Olegovich; Samoylov, Denis Vladimirovich

2015-04-01

An express method for determination of acidity constants of organic acids, based on the analysis of the integral transmittance vs. pH dependence is developed. The integral value is registered as a photocurrent of photometric device simultaneously with potentiometric titration. The proposed method allows to obtain pKa using only simple and low-cost instrumentation. The optical part of the experimental setup has been optimized through the exclusion of the monochromator device. Thus it only takes 10-15 min to obtain one pKa value with the absolute error of less than 0.15 pH units. Application limitations and reliability of the method have been tested for a series of organic acids of various nature.

Überlegungen zu der sumerischen Zeichen-Gruppe ŠÈ.KA

Directory of Open Access Journals (Sweden)

Such-Gutiérrez, Marcos

2003-12-01

Full Text Available This paper deals with the different readings and meanings of the signs ŠÈ.KA. One of these readings is Zì.KA or zì-KA/ka, which has been traditionally interpreted as a kind of flour or as the process of milling. However, a revision of the texts from the Third Dynasty of Ur (c. 2117-2008 B.C., in which the group of signs ZÌ.KA o zì-KA/ka appears, shows that this term is actually a kind of gift.

El presente artículo trata de las diferentes lecturas y significados del grupo de signos ŠÈ.KA. Entre dichas lecturas se encuentra la de ZÌ.KA o zì-KA/ka, que ha sido tradicionalmente interpretada bien como un tipo de harina, o bien como la acción que conduce a su fabricación. Sin embargo, una revisión de los textos de la III Dinastía de Ur (c. 2117-2008 a.C. en los que aparece el término ZÌ.KA o zì-KA/ka demuestra que, en realidad, con él se hace referencia a un tipo de regalo.

A wave-bending structure at Ka-band using 3D-printed metamaterial

Science.gov (United States)

Wu, Junqiang; Liang, Min; Xin, Hao

2018-03-01

Three-dimensional printing technologies enable metamaterials of complex structures with arbitrary inhomogeneity. In this work, a 90° wave-bending structure at the Ka-band (26.5-40 GHz) based on 3D-printed metamaterials is designed, fabricated, and measured. The wave-bending effect is realized through a spatial distribution of varied effective dielectric constants. Based on the effective medium theory, different effective dielectric constants are accomplished by special, 3D-printable unit cells, which allow different ratios of dielectric to air at the unit cell level. In contrast to traditional, metallic-structure-included metamaterial designs, the reported wave-bending structure here is all dielectric and implemented by the polymer-jetting technique, which features rapid, low-cost, and convenient prototyping. Both simulation and experiment results demonstrate the effectiveness of the wave-bending structure.

Experimental determination of net protein charge and A(tot) and K(a) of nonvolatile buffers in human plasma.

Science.gov (United States)

Staempfli, Henry R; Constable, Peter D

2003-08-01

The mechanism for an acid-base disturbance can be determined by using the strong ion approach, which requires species-specific values for the total concentration of plasma nonvolatile buffers (Atot) and the effective dissociation constant for plasma weak acids (Ka). The aim of this study was to experimentally determine Atot and Ka values for human plasma by using in vitro CO2 tonometry. Plasma Pco2 was systematically varied from 25 to 145 Torr at 37 degrees C, thereby altering plasma pH over the physiological range of 6.90-7.55, and plasma pH, Pco2, and concentrations of quantitatively important strong ions (Na+, K+, Ca2+, Mg2+, Cl-, lactate) and buffer ions (total protein, albumin, phosphate) were measured. Strong ion difference was estimated, and nonlinear regression was used to calculate Atot and Ka from the measured pH and Pco2 and estimated strong ion difference; the Atot and Ka values were then validated by using a published data set (Figge J, Rossing TH, and Fencl V, J Lab Clin Med 117: 453-467, 1991). The values (mean +/- SD) were as follows: Atot = 17.2 +/- 3.5 mmol/l (equivalent to 0.224 mmol/g of protein or 0.378 mmol/g of albumin); Ka = 0.80 +/- 0.60 x 10-7; negative log of Ka = 7.10. Mean estimates were obtained for strong ion difference (37 meq/l) and net protein charge (13+.0 meq/l). The experimentally determined values for Atot, Ka, and net protein charge should facilitate the diagnosis and treatment of acid-base disturbances in critically ill humans.

A 130 ka reconstruction of rainfall on the Bolivian Altiplano

Science.gov (United States)

Placzek, C. J.; Quade, J.; Patchett, P. J.

2013-02-01

New efforts to link climate reconstructions from shoreline deposits and sediment cores yield an improved and more detailed lake history from the Bolivian Altiplano. On the Southern Altiplano, 10 lake oscillations have been identified from this new unified chronology, each coincident with North Atlantic cold events such as Heinrich Events H5, H2, H1, and the Younger Dryas. By coupling this new lake history to a hydrologic budget model we are able to evaluate precipitation variability on the Southern Bolivian Altiplano over the last 130 ka. These modeling efforts underscore the relative aridity of the Altiplano during the rare and small lake cycles occurring between 80 and 20 ka, when colder temperatures combined with little or no change in rainfall produced smaller paleolakes. Relative aridity between 80 and 20 ka contrasts with the immense Tauca lake cycle (18.1-14.1 ka), which was six times larger than modern Lake Titicaca and coincided with Heinrich Event 1. This improved paleolake record from the Southern Altiplano reveals a strong link between central Andean climate and Atlantic sea-surface temperature gradients during the late Pleistocene, even though today rainfall variability is driven mostly by Pacific sea-surface temperature anomalies associated with El Niño/Southern Oscillation. However, not all Heinrich Events appear to result in lake expansions, most conspicuously during the global cold interval between 80 and 20 ka when the Altiplano and Amazon Basin were relatively arid.

Photometric method for determination of acidity constants through integral spectra analysis.

Science.gov (United States)

Zevatskiy, Yuriy Eduardovich; Ruzanov, Daniil Olegovich; Samoylov, Denis Vladimirovich

2015-04-15

An express method for determination of acidity constants of organic acids, based on the analysis of the integral transmittance vs. pH dependence is developed. The integral value is registered as a photocurrent of photometric device simultaneously with potentiometric titration. The proposed method allows to obtain pKa using only simple and low-cost instrumentation. The optical part of the experimental setup has been optimized through the exclusion of the monochromator device. Thus it only takes 10-15 min to obtain one pKa value with the absolute error of less than 0.15 pH units. Application limitations and reliability of the method have been tested for a series of organic acids of various nature. Copyright © 2015 Elsevier B.V. All rights reserved.

Quench Propagation in the Superconducting 6 kA Flexible Busbars of the LHC

OpenAIRE

Calvi, M; Herzog, R; Pelegrin-Carcelen, J M; Sonnemann, F

2001-01-01

Flexible superconducting cables with currents up to 6 kA will be used to power magnets individually in the insertion regions of the LHC. In case of a quench, the currents in these circuits will decay very fast (with time constants of about 200 ms) such that relatively small copper cross sections are sufficient for these busbars. Quench propagation experiments on a prototype cable and corresponding simulations led to a detailed understanding of the quench behavior of these busbars and to recom...

Estimation of thermodynamic acidity constants of some penicillinase-resistant penicillins.

Science.gov (United States)

Demiralay, Ebru Çubuk; Üstün, Zehra; Daldal, Y Doğan

2014-03-01

In this work, thermodynamic acidity constants (pssKa) of methicillin, oxacillin, nafcillin, cloxacilin, dicloxacillin were determined with reverse phase liquid chromatographic method (RPLC) by taking into account the effect of the activity coefficients in hydro-organic water-acetonitrile binary mixtures. From these values, thermodynamic aqueous acidity constants of these drugs were calculated by different approaches. The linear relationships established between retention factors of the species and the polarity parameter of the mobile phase (ET(N)) was proved to predict accurately retention in LC as a function of the acetonitrile content (38%, 40% and 42%, v/v). Copyright © 2013 Elsevier B.V. All rights reserved.

Quench propagation in the superconducting 6 kA flexible busbars of the LHC

International Nuclear Information System (INIS)

Herzog, R.; Calvi, M.; Sonnemann, F.; Pelegrin-Carcelen, J.M.

2002-01-01

Flexible superconducting cables with currents up to 6 kA will be used to power magnets individually in the insertion regions of the LHC. In case of a quench, the currents in these circuits will decay very fast (with time constants of about 200 ms) such that relatively small copper cross sections are sufficient for these busbars. Quench propagation experiments on a prototype cable and corresponding simulations led to a detailed understanding of the quench behavior of these busbars and to recommendations for the design and application of the cable. Simulations of the quench process in a multi-strand conductor led to a detailed understanding of the way current crosses from superconducting to pure copper strands and how this affects the quench propagation velocity. At nominal current (6 kA), the quench propagation velocities are high (10 m/s) and the hot spot temperature increases rapidly. In this situation, timely quench detection and energy extraction (current reduction) are vital to prevent damage of circuit components

Quench Propagation in the Superconducting 6 kA Flexible Busbars of the LHC

CERN Document Server

Calvi, M; Pelegrin-Carcelen, J M; Sonnemann, F

2002-01-01

Flexible superconducting cables with currents up to 6 kA will be used to power magnets individually in the insertion regions of the LHC. In case of a quench, the currents in these circuits will decay very fast (with time constants of about 200 ms) such that relatively small copper cross sections are sufficient for these busbars. Quench propagation experiments on a prototype cable and corresponding simulations led to a detailed understanding of the quench behavior of these busbars and to recommendations for the design and application of the cable. Simulations of the quench process in a multi-strand conductor led to a detailed understanding of the way current crosses from superconducting to pure copper strands and how this affects the quench propagation velocity. At nominal current (6 kA), the quench propagation velocities are high (10 m/s) and the hot spot temperature increases rapidly. In this situation, timely quench detection and energy extraction (current reduction) are vital to prevent damage of circuit c...

Quench propagation in the superconducting 6 kA flexible busbars of the LHC

Science.gov (United States)

Herzog, R.; Calvi, M.; Sonnemann, F.; Pelegrin-Carcelen, J. M.

2002-05-01

Flexible superconducting cables with currents up to 6 kA will be used to power magnets individually in the insertion regions of the LHC. In case of a quench, the currents in these circuits will decay very fast (with time constants of about 200 ms) such that relatively small copper cross sections are sufficient for these busbars. Quench propagation experiments on a prototype cable and corresponding simulations led to a detailed understanding of the quench behavior of these busbars and to recommendations for the design and application of the cable. Simulations of the quench process in a multi-strand conductor led to a detailed understanding of the way current crosses from superconducting to pure copper strands and how this affects the quench propagation velocity. At nominal current (6 kA), the quench propagation velocities are high (10 m/s) and the hot spot temperature increases rapidly. In this situation, timely quench detection and energy extraction (current reduction) are vital to prevent damage of circuit components.

The sensitivity of the Late Saalian (140 ka) and LGM (21 ka) Eurasian ice sheets to sea surface conditions

Energy Technology Data Exchange (ETDEWEB)

Colleoni, Florence [Centro Euro-Mediterraneo per i Cambiamenti Climatici, Bologna (Italy); UJF, CNRS, Laboratoire de Glaciologie et Geophysique de l' Environnement, Saint Martin d' Heres Cedex (France); Stockholm University, Department of Geological Sciences, Stockhlom (Sweden); Liakka, Johan [Stockholm University, Department of Meteorology, Stockholm (Sweden); Krinner, Gerhard; Peyaud, Vincent [UJF, CNRS, Laboratoire de Glaciologie et Geophysique de l' Environnement, Saint Martin d' Heres Cedex (France); Jakobsson, Martin [Stockholm University, Department of Geological Sciences, Stockhlom (Sweden); Masina, Simona [Centro Euro-Mediterraneo per i Cambiamenti Climatici, Istituto Nazionale di Geofisica e Vulcanologia, Bologna (Italy)

2011-08-15

This work focuses on the Late Saalian (140 ka) Eurasian ice sheets' surface mass balance (SMB) sensitivity to changes in sea surface temperatures (SST). An Atmospheric General Circulation Model (AGCM), forced with two preexisting Last Glacial Maximum (LGM, 21 ka) SST reconstructions, is used to compute climate at 140 and 21 ka (reference glaciation). Contrary to the LGM, the ablation almost stopped at 140 ka due to the climatic cooling effect from the large ice sheet topography. Late Saalian SST are simulated using an AGCM coupled with a mixed layer ocean. Compared to the LGM, these 140 ka SST show an inter-hemispheric asymmetry caused by the larger ice-albedo feedback, cooling climate. The resulting Late Saalian ice sheet SMB is smaller due to the extensive simulated sea ice reducing the precipitation. In conclusion, SST are important for the stability and growth of the Late Saalian Eurasian ice sheet. (orig.)

Reaction rate constant for radiative association of CF{sup +}

Energy Technology Data Exchange (ETDEWEB)

Öström, Jonatan, E-mail: jonatan.ostrom@gmail.com; Gustafsson, Magnus, E-mail: magnus.gustafsson@ltu.se [Applied Physics, Division of Materials Science, Department of Engineering Science and Mathematics, Luleå University of Technology, 97187 Luleå (Sweden); Bezrukov, Dmitry S. [Department of Chemistry, M. V. Lomonosov Moscow State University, Moscow, 119991 (Russian Federation); Nyman, Gunnar [Department of Chemistry and Molecular Biology, University of Gothenburg, 41296 Gothenburg (Sweden)

2016-01-28

Reaction rate constants and cross sections are computed for the radiative association of carbon cations (C{sup +}) and fluorine atoms (F) in their ground states. We consider reactions through the electronic transition 1{sup 1}Π → X{sup 1}Σ{sup +} and rovibrational transitions on the X{sup 1}Σ{sup +} and a{sup 3}Π potentials. Semiclassical and classical methods are used for the direct contribution and Breit–Wigner theory for the resonance contribution. Quantum mechanical perturbation theory is used for comparison. A modified formulation of the classical method applicable to permanent dipoles of unequally charged reactants is implemented. The total rate constant is fitted to the Arrhenius–Kooij formula in five temperature intervals with a relative difference of <3%. The fit parameters will be added to the online database KIDA. For a temperature of 10–250 K, the rate constant is about 10{sup −21} cm{sup 3} s{sup −1}, rising toward 10{sup −16} cm{sup 3} s{sup −1} for a temperature of 30 000 K.

ATLAS computing operations within the GridKa Cloud

International Nuclear Information System (INIS)

Kennedy, J; Walker, R; Olszewski, A; Nderitu, S; Serfon, C; Duckeck, G

2010-01-01

The organisation and operations model of the ATLAS T1-T2 federation/Cloud associated to the GridKa T1 in Karlsruhe is described. Attention is paid to Cloud level services and the experience gained during the last years of operation. The ATLAS GridKa Cloud is large and divers spanning 5 countries, 2 ROC's and is currently comprised of 13 core sites. A well defined and tested operations model in such a Cloud is of the utmost importance. We have defined the core Cloud services required by the ATLAS experiment and ensured that they are performed in a managed and sustainable manner. Services such as Distributed Data Management involving data replication,deletion and consistency checks, Monte Carlo Production, software installation and data reprocessing are described in greater detail. In addition to providing these central services we have undertaken several Cloud level stress tests and developed monitoring tools to aid with Cloud diagnostics. Furthermore we have defined good channels of communication between ATLAS, the T1 and the T2's and have pro-active contributions from the T2 manpower. A brief introduction to the GridKa Cloud is provided followed by a more detailed discussion of the operations model and ATLAS services within the Cloud.

Deep space propagation experiments at Ka-band

Science.gov (United States)

Butman, Stanley A.

1990-01-01

Propagation experiments as essential components of the general plan to develop an operational deep space telecommunications and navigation capability at Ka-band (32 to 35 GHz) by the end of the 20th century are discussed. Significant benefits of Ka-band over the current deep space standard X-band (8.4 GHz) are an improvement of 4 to 10 dB in telemetry capacity and a similar increase in radio navigation accuracy. Propagation experiments are planned on the Mars Observer Mission in 1992 in preparation for the Cassini Mission to Saturn in 1996, which will use Ka-band in the search for gravity waves as well as to enhance telemetry and navigation at Saturn in 2002. Subsequent uses of Ka-band are planned for the Solar Probe Mission and the Mars Program.

Constant pH molecular dynamics of proteins in explicit solvent with proton tautomerism.

Science.gov (United States)

Goh, Garrett B; Hulbert, Benjamin S; Zhou, Huiqing; Brooks, Charles L

2014-07-01

pH is a ubiquitous regulator of biological activity, including protein-folding, protein-protein interactions, and enzymatic activity. Existing constant pH molecular dynamics (CPHMD) models that were developed to address questions related to the pH-dependent properties of proteins are largely based on implicit solvent models. However, implicit solvent models are known to underestimate the desolvation energy of buried charged residues, increasing the error associated with predictions that involve internal ionizable residue that are important in processes like hydrogen transport and electron transfer. Furthermore, discrete water and ions cannot be modeled in implicit solvent, which are important in systems like membrane proteins and ion channels. We report on an explicit solvent constant pH molecular dynamics framework based on multi-site λ-dynamics (CPHMD(MSλD)). In the CPHMD(MSλD) framework, we performed seamless alchemical transitions between protonation and tautomeric states using multi-site λ-dynamics, and designed novel biasing potentials to ensure that the physical end-states are predominantly sampled. We show that explicit solvent CPHMD(MSλD) simulations model realistic pH-dependent properties of proteins such as the Hen-Egg White Lysozyme (HEWL), binding domain of 2-oxoglutarate dehydrogenase (BBL) and N-terminal domain of ribosomal protein L9 (NTL9), and the pKa predictions are in excellent agreement with experimental values, with a RMSE ranging from 0.72 to 0.84 pKa units. With the recent development of the explicit solvent CPHMD(MSλD) framework for nucleic acids, accurate modeling of pH-dependent properties of both major class of biomolecules-proteins and nucleic acids is now possible. © 2013 Wiley Periodicals, Inc.

Franchisingkäsikirjan tuottaminen käytettyjen valokuvaustarvikkeiden verkkokaupalle

OpenAIRE

Heikkinen, Antti

2015-01-01

Tämän opinnäytetyön tarkoituksena oli luoda selkeä ja helppokäyttöinen franchisingkäsikirja Kameratori Oy:lle. Kameratori on vuonna 2010 perustettu käytettyyn valokuvauskalustoon keskittyvä verkkokauppa, joka myy Tampereen toimitiloista käsin kuntotarkistettua kuvauskalustoa Suomeen ja maailmalle. Franchisingkäsikirjaan on dokumentoitu Kameratori.fi-verkkosivuston käyttöön tarvittava ohjeistus. Käsikirja on yksi olennaisimmista dokumenteista franchisingantajan ja -ottajien...

Experimental determination of net protein charge, [A]tot, and Ka of nonvolatile buffers in bird plasma.

Science.gov (United States)

Stämpfli, Henry; Taylor, Michael; McNicoll, Carl; Gancz, Ady Y; Constable, Peter D

2006-06-01

The quantitative mechanistic acid-base approach to clinical assessment of acid-base status requires species-specific values for [A]tot (the total concentration of nonvolatile buffers in plasma) and Ka (the effective dissociation constant for weak acids in plasma). The aim of this study was to determine [A]tot and Ka values for plasma in domestic pigeons. Plasma from 12 healthy commercial domestic pigeons was tonometered with 20% CO2 at 37 degrees C. Plasma pH, Pco2, and plasma concentrations of strong cations (Na, K, Ca), strong anions (Cl, L-lactate), and nonvolatile buffer ions (total protein, albumin, phosphate) were measured over a pH range of 6.8-7.7. Strong ion difference (SID) (SID5=Na+K+Ca-Cl-lactate) was used to calculate [A]tot and Ka from the measured pH and Pco2 and SID5. Mean (+/-SD) values for bird plasma were as follows: [A]tot=7.76+/-2.15 mmol/l (equivalent to 0.32 mmol/g of total protein, 0.51 mmol/g of albumin, 0.23 mmol/g of total solids); Ka=2.15+/-1.15x10(-7); and pKa=6.67. The net protein charge at normal pH (7.43) was estimated to be 6 meq/l; this value indicates that pigeon plasma has a much lower anion gap value than mammals after adjusting for high mean L-lactate concentrations induced by restraint during blood sampling. This finding indicates that plasma proteins in pigeons have a much lower net anion charge than mammalian plasma protein. An incidental finding was that total protein concentration measured by a multianalyzer system was consistently lower than the value for total solids measured by refractometer.

Ulukiliha sobib ka jõululauale / Raivo Feldmann

Index Scriptorium Estoniae

Feldmann, Raivo

2009-01-01

Adavere lihakauplusest, mida on külastanud ka president Toomas Hendrik Ilves ja proua Evelin Ilves. OÜ Chef Foodsi kaupa tellib ka presidendi kantselei. Juuresoleval fotol president Toomas Hendrik Ilves ja proua Evelin Ilves koos OÜ Chef Foodsi juhatuse liikme Veiko Villemi ja juhataja Priit Noorhaniga

Features of the ESI mechanism that affect the observation of multiply charged noncovalent protein complexes and the determination of the association constant by the titration method.

Science.gov (United States)

Peschke, Michael; Verkerk, Udo H; Kebarle, Paul

2004-10-01

Several factors, attributable to the ESIMS mechanism, that can affect the assumptions of the titration method are examined: (1) The assumption that the concentrations in solution of the protein P, the ligand L, and the complex PL are proportional to the respective ion intensities observed with ESIMS, is examined with experiments in which ion intensities of two non-interacting proteins are compared with the respective concentrations. The intensities are found to be approximately proportional to the concentrations. The proportionality factors are found to increase as the mass of the protein is decreased. Very small proteins have much higher intensities. The results suggest that it is preferable to use only the intensity ratio of PL and P, whose masses are very close to each other when L is small, to determine the association constant KA in solution. (2) From the charge residue model (CRM) one expects that the solution will experience a very large increase of concentration due to evaporation of the precursor droplets, before the proteins P and PL are produced in the gas phase. This can shift the equilibrium in the droplets: P + L = PL, towards PL. Analysis of the droplet evaporation history shows that such a shift is not likely, because the time of droplet evolution is very short, only several micros, and the equilibrium relaxation time is much longer. (3) The droplet history shows that unreacted P and L can be often present together in the same droplet. On complete evaporation of such droplets L will land on P leading to PL and this effect will lead to values of KA that are too high. However, it is argued that mostly accidental, weakly bonded, complexes will form and these will dissociate in the clean up stages (heated transfer capillary and CAD region). Thus only very small errors are expected due to this cause. (4) Some PL complexes may have bonding that is too weak in the gas phase even though they have KA values in solution that predict high solution PL yields

Determination and structural correlation of the pKa values of p-substituted trans-2,3-epoxy-4-oxo-4-phenylbutanoic acids

Directory of Open Access Journals (Sweden)

I. JURANIC

2000-11-01

Full Text Available The pKa values for a series of eight p-substituted trans-2,3-epoxy-4-phenyl butanoic acids (p-substituted trans-b-aroylepoxyacrylic acids have been determined potentiometrically in aqueous media at 25°C at an ionic strength of 0.1 mol/dm3 (NaCl. The transmission of polar effects from the substituents on the phenyl nucleus to the carboxylic group through the side chain involving a carbonyl group and an epoxide ring was investigated. The pKa values were correlated with structure using the Hammett, Taft and Yukawa-Tsuno approaches. The Hammett r constant (0.34 was compared with analogue values for structurally similar acids.

Multiple Nonconformities in Ice-Walled Lake Successions Indicate Periods with Cold Summers (24.4 - 22.5 ka, 21.1 - 19.2 ka, 18.5 - 18.1 ka) during the Last Deglaciation in Northeastern Illinois, USA

Science.gov (United States)

Curry, B. B.

2014-12-01

Unprecedented age control on many last glacial stratigraphic units and morainal ice-margin positions are interpreted from AMS radiocarbon ages of tundra plant macrofossils archived in low-relief ice-walled lake plain (IWLP) deposits the Lake Michigan Lobe (south-central Laurentide Ice Sheet). IWLPs are periglacial features that formed on morainal dead-ice permafrost. Lacustrine sediment, and the fossils contained therein, had physical and temporal proximity to the glacier which formed the underlying moraine. In modern ice-walled lakes, as the lake's ice cover begins to melt, moats form which allows access of sloughing tundra-mantled active layer sediment (soil) into the lakes. Multiple AMS ages from two sites with proglacial sediment buried by glacial max LIS diamicton, and IWLPs reveal evidence of episodic plant growth and sedimentation including ca. 24.0 to 24.4 ka (post Shelby Phase), 22.5 to 21.1 ka (post Livingston Phase), 18.1 to 17.4 ka (post Woodstock Phase). Although presently based on negative evidence, the associated nonconformities (listed in title) indicate periods when cold conditions did not promote development of the estival moat. Although the evidence does not preclude tundra growth during the cold summers, there was little landscape modification due to limited thawing of the active layer. At approximately the onset of the 19.2-18.5 "warm" period, at least two large deglacial discharge events flooded the Fox and Kankakee tributary valleys of the Illinois River. The latter, known as the Kankakee Torrent, occurred at 19.05 - 18.85 ka (σ1 range) at the Oswego channel complex. The temporal coincidence of the torrents and sedimentation in ice-walled lakes suggests that the post-Livingston Phase nonconformity (21.1 - 19.2 ka) was a period of lessened meltwater discharge through subglacial conduits (tunnel valleys) as the frozen toe promoted formation of subglacial lakes, buildup of pore-water pressures, and the release of subglacial water as "torrents

Kuulus dress ka Evelinile!

Index Scriptorium Estoniae

2009-01-01

Proua Evelin Ilves kinkis Eestis esinenud popstaar Madonnale eesti rahvusmotiividega dressid. Sarnased spordirõivad tulevad müügile ka Tallinnas Viru keskuses Bastioni esinduskaupluses. Proua Evelin Ilvesele valmistatakse ainulaadsed valgest kangast dressid

Experimental determination of net protein charge and A(tot) and K(a) of nonvolatile buffers in canine plasma.

Science.gov (United States)

Constable, Peter D; Stämpfli, Henry R

2005-01-01

Acid-base abnormalities frequently are present in sick dogs. The mechanism for an acid-base disturbance can be determined with the simplified strong ion approach, which requires accurate values for the total concentration of plasma nonvolatile buffers (A(tot)) and the effective dissociation constant for plasma weak acids (K(a)). The aims of this study were to experimentally determine A(tot) and K(a) values for canine plasma. Plasma was harvested from 10 healthy dogs; the concentrations of quantitatively important strong ions (Na+, K+, Ca2+, Mg2+, Cl-, L-lactate) and nonvolatile buffer ions (total protein, albumin, phosphate) were determined; and the plasma was tonometered with CO2 at 37 degrees C. Strong ion difference (SID) was calculated from the measured strong ion concentrations, and nonlinear regression was used to estimate values for A(tot) and K(a), which were validated with data from an in vitro and in vivo study. Mean (+/- SD) values for canine plasma were A(tot) = (17.4 +/- 8.6) mM (equivalent to 0.273 mmol/g of total protein or 0.469 mmol/g of albumin); K(a) = (0.17 +/- 0.11) x 10(-7); pK(a) = 7.77. The calculated SID for normal canine plasma (pH = 7.40; P(CO2) = 37 mm Hg; [total protein] = 64 g/L) was 27 mEq/L. The net protein charge for normal canine plasma was 0.25 mEq/g of total protein or 0.42 mEq/g of albumin. Application of the experimentally determined values for A(tot), K(a), and net protein charge should improve understanding of the mechanism for complex acid-base disturbances in dogs.

Multi-Step Ka/Ka Dichroic Plate with Rounded Corners for NASA's 34m Beam Waveguide Antenna

Science.gov (United States)

Veruttipong, Watt; Khayatian, Behrouz; Hoppe, Daniel; Long, Ezra

2013-01-01

A multi-step Ka/Ka dichroic plate Frequency Selective Surface (FSS structure) is designed, manufactured and tested for use in NASA's Deep Space Network (DSN) 34m Beam Waveguide (BWG) antennas. The proposed design allows ease of manufacturing and ability to handle the increased transmit power (reflected off the FSS) of the DSN BWG antennas from 20kW to 100 kW. The dichroic is designed using HFSS and results agree well with measured data considering the manufacturing tolerances that could be achieved on the dichroic.

Determination of pKa values of new phenacyl-piperidine derivatives by potentiometric titration method in aqueous medium at room temperature (25±0.5oC).

Science.gov (United States)

Zafar, Shaista; Akhtar, Shamim; Tariq, Talat; Mushtaq, Noushin; Akram, Arfa; Ahmed, Ahsaan; Arif, Muhammad; Naeem, Sabahat; Anwar, Sana

2014-07-01

Dissociation constant (pKa) of ten novel phenacyl derivatives of piperidine were determined by potentiometric titration method in aqueous medium at room temperature (25 ±0.5°C). The sample solutions were prepared in deionized water with ionic strength 0.01M and titrated with 0.1M NaOH solution. In addition, ΔG values were also calculated. Different prediction software programs were used to calculate pKa values too and compared to the experimentally observed pKa values. The experimental and theoretical values were found in close agreement. The results obtained in this research would help to predict the good absorption of the studied compounds and can be selected as lead molecules for the synthesis of CNS active agents because of their lipophilic nature especially compound VII.

Rationalization of the pKa values of alcohols and thiols using atomic charge descriptors and its application to the prediction of amino acid pKa's.

Science.gov (United States)

Ugur, Ilke; Marion, Antoine; Parant, Stéphane; Jensen, Jan H; Monard, Gerald

2014-08-25

In a first step toward the development of an efficient and accurate protocol to estimate amino acids' pKa's in proteins, we present in this work how to reproduce the pKa's of alcohol and thiol based residues (namely tyrosine, serine, and cysteine) in aqueous solution from the knowledge of the experimental pKa's of phenols, alcohols, and thiols. Our protocol is based on the linear relationship between computed atomic charges of the anionic form of the molecules (being either phenolates, alkoxides, or thiolates) and their respective experimental pKa values. It is tested with different environment approaches (gas phase or continuum solvent-based approaches), with five distinct atomic charge models (Mulliken, Löwdin, NPA, Merz-Kollman, and CHelpG), and with nine different DFT functionals combined with 16 different basis sets. Moreover, the capability of semiempirical methods (AM1, RM1, PM3, and PM6) to also predict pKa's of thiols, phenols, and alcohols is analyzed. From our benchmarks, the best combination to reproduce experimental pKa's is to compute NPA atomic charge using the CPCM model at the B3LYP/3-21G and M062X/6-311G levels for alcohols (R(2) = 0.995) and thiols (R(2) = 0.986), respectively. The applicability of the suggested protocol is tested with tyrosine and cysteine amino acids, and precise pKa predictions are obtained. The stability of the amino acid pKa's with respect to geometrical changes is also tested by MM-MD and DFT-MD calculations. Considering its strong accuracy and its high computational efficiency, these pKa prediction calculations using atomic charges indicate a promising method for predicting amino acids' pKa in a protein environment.

Kan Kaşanmak Deyimi Üzerine On The Idiom Kan Kaşanmak

Directory of Open Access Journals (Sweden)

Yaşar ŞİMŞEK

2013-03-01

Full Text Available Mankind chose to tell his own feeling and thoughts with stereotyped words by using the expression facilities of his vernacular. The meaning of stereotyped words form as community's mutual thought's product by switching of the word or phrase's first meaning via simile. Idioms have a crucial place in regard to show the expression facilities in stereotyped words. That's why, the detection of entitiy in a language have an importance. In this essay, it will be dwelled on the idiom "kan kaşanmak"which is forgotten in these days, on the other hand; is mentioned oftenin Old Anatolian Turkish texts. The essay is composed of two parts. Inthe first part; the word kaşanmak's usage which is used in the meaningof "to urinate" in Uighur Turkish, Karakhanid Turkish, ChagataiTurkish, Qipchaq Turkish and Old Anatolian Turkish since Old Turkishperiod and today exists in Anatolian and Azerbaijan dialects, is going tobe tried to be shown with examples now that it forms a basis for "kankaşanmak" idiom.In the second part of the study, it will be dwelled on the idiom kankaşanmak's meaning transformation which is idiomatic form of theword kaşanmak, starting with the first meaning of it. The first meaningof the idiom kan kaşanmak means "to urinate blood, but later itbecomes a idiom by meaning transformation; in the meaning of"frighten to death, be scared as piss oneself, be scared as peeing bloodand this is going to be shown with examples. The study is going to befinished with showing the idiom's first meaning which is used in today'sAnatolian dialects usage " using an animal to carry load and animal'speeing blood because of the heavy burden" in the close meaning it isused for people too. İnsanoğlu, konuştuğu dilin ifade olanaklarını kullanarak, kendisine has duygu ve düşünceleri kalıplaşmış sözlerle anlatma yoluna gitmiştir. Kalıplaşmış sözlerin anlamı, sözcüğün ya da sözcük grubunun ilk anlamından mecaz yolu ile geçiş yaparak halk

Determination of Acid Dissociation Constants (pKa) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent

Science.gov (United States)

Nural, Yahya; Döndaş, H. Ali; Sarı, Hayati; Atabey, Hasan; Belveren, Samet; Gemili, Müge

2014-01-01

The acid dissociation constants of potential bioactive fused ring thiohydantoin-pyrrolidine compounds were determined by potentiometric titration in 20% (v/v) ethanol-water mixed at 25 ± 0.1°C, at an ionic background of 0.1 mol/L of NaCl using the HYPERQUAD computer program. Proton affinities of potential donor atoms of the ligands were calculated by AM1 and PM3 semiempiric methods. We found, potentiometrically, three different acid dissociation constants for 1a–f. We suggest that these acid dissociation constants are related to the carboxyl, enol, and amino groups. PMID:24799905

Briti korruptsioonivastane seadus kehtib ka Eestis / Tõnis Tamme

Index Scriptorium Estoniae

Tamme, Tõnis, 1972-

2011-01-01

Suurbritannias jõustub 1. juulil 2011 uus korruptsioonivastane seadus (Bribery Act 2010), mis kehtib ühtmoodi nii Briti ettevõtetele kui ka mujal maailmas asutatud äriühingutele, kelle äritegevus või ka osa sellest omab puutumust Suurbritanniaga

Determination of association constants between steroid compounds and albumins by partial-filling ACE.

Science.gov (United States)

Amundsen, Lotta K; Sirén, Heli

2007-10-01

ACE is a popular technique for evaluating association constants between drugs and proteins. However, ACE has not previously been applied to study the association between electrically neutral biomolecules and plasma proteins. We studied the affinity between human and bovine serum albumins (HSA and BSA, respectively) and three neutral endogenous steroid hormones (testosterone, epitestosterone and androstenedione) and two synthetic analogues (methyltestosterone and fluoxymesterone) by applying the partial-filling technique in ACE (PF-ACE). From the endocrinological point of view, the distribution of endogenous steroids among plasma components is of great interest. Strong interactions with albumins suppress the biological activity of steroids. Notable differences in the association constants were observed. In the case of the endogenous steroids, the interactions between testosterone and the albumins were strongest, and those between androstenedione and the albumins were substantially weaker. The association constants, K(b), for testosterone, epitestosterone and androstenedione and HSA at 37 degrees C were 32 100 +/- 3600, 21 600 +/- 1500 and 13 300 +/- 1300 M(-1), respectively, while the corresponding values for the steroids and BSA were 18 800 +/- 1500, 14 000 +/- 400 and 7800 +/- 900 M(-1). Methyltestosterone was bound even more strongly than testosterone, while fluoxymesterone was only weakly bound by the albumins. Finally, the steroids were separated by PF-ACE with HSA and BSA used as resolving components.

Concentrating Solar Power Projects - KaXu Solar One | Concentrating Solar

Science.gov (United States)

Power | NREL KaXu Solar One This page provides information on KaXu Solar One, a concentrating solar power (CSP) project, with data organized by background, parcipants and power plant configuration . Status Date: April 14, 2015 Project Overview Project Name: KaXu Solar One Country: South Africa Location

ATLAS operations in the GridKa T1/T2 Cloud

International Nuclear Information System (INIS)

Duckeck, G; Serfon, C; Walker, R; Harenberg, T; Kalinin, S; Schultes, J; Kawamura, G; Leffhalm, K; Meyer, J; Nderitu, S; Olszewski, A; Petzold, A; Sundermann, J E

2011-01-01

The ATLAS GridKa cloud consists of the GridKa Tier1 centre and 12 Tier2 sites from five countries associated to it. Over the last years a well defined and tested operation model evolved. Several core cloud services need to be operated and closely monitored: distributed data management, involving data replication, deletion and consistency checks; support for ATLAS production activities, which includes Monte Carlo simulation, reprocessing and pilot factory operation; continuous checks of data availability and performance for user analysis; software installation and database setup. Of crucial importance is good communication between sites, operations team and ATLAS as well as efficient cloud level monitoring tools. The paper gives an overview of the operations model and ATLAS services within the cloud.

Mars Global Surveyor Ka-Band Frequency Data Analysis

Science.gov (United States)

Morabito, D.; Butman, S.; Shambayati, S.

2000-01-01

The Mars Global Surveyor (MGS) spacecraft, launched on November 7, 1996, carries an experimental space-to-ground telecommunications link at Ka-band (32 GHz) along with the primary X-band (8.4 GHz) downlink. The signals are simultaneously transmitted from a 1.5-in diameter parabolic high gain antenna (HGA) on MGS and received by a beam-waveguide (BWG) R&D 34-meter antenna located in NASA's Goldstone Deep Space Network (DSN) complex near Barstow, California. The projected 5-dB link advantage of Ka-band relative to X-band was confirmed in previous reports using measurements of MGS signal strength data acquired during the first two years of the link experiment from December 1996 to December 1998. Analysis of X-band and Ka-band frequency data and difference frequency (fx-fka)/3.8 data will be presented here. On board the spacecraft, a low-power sample of the X-band downlink from the transponder is upconverted to 32 GHz, the Ka-band frequency, amplified to I-W using a Solid State Power Amplifier, and radiated from the dual X/Ka HGA. The X-band signal is amplified by one of two 25 W TWTAs. An upconverter first downconverts the 8.42 GHz X-band signal to 8 GHz and then multiplies using a X4 multiplier producing the 32 GHz Ka-band frequency. The frequency source selection is performed by an RF switch which can be commanded to select a VCO (Voltage Controlled Oscillator) or USO (Ultra-Stable Oscillator) reference. The Ka-band frequency can be either coherent with the X-band downlink reference or a hybrid combination of the USO and VCO derived frequencies. The data in this study were chosen such that the Ka-band signal is purely coherent with the X-band signal, that is the downconverter is driven by the same frequency source as the X-band downlink). The ground station used to acquire the data is DSS-13, a 34-meter BWG antenna which incorporates a series of mirrors inside beam waveguide tubes which guide the energy to a subterranean pedestal room, providing a stable environment

Eolian depositional phases during the past 50 ka and inferred climate variability for the Pampean Sand Sea, western Pampas, Argentina

Science.gov (United States)

Tripaldi, Alfonsina; Forman, Steven L.

2016-05-01

The Pampean Sand Sea, which occurs from the Argentinian Pampas to the eastern Andean piedmont, hosts presently stabilized dune fields spanning the late Quaternary. This study integrates previous results and presents new geomorphic, stratigraphic, sedimentological, and chronologic data for nineteen >2 m-thick eolian successions for the San Luis paleo-dune field, western Pampas, to better constrain the depositional history. Six eolian depositional phases are identified spanning the past 50 ka, interposed with paleosols and/or bounded by erosive surfaces. Age control was from 61 OSL ages of small aliquots of quartz grains from eolian stratigraphic units. The inferred timing of eolian phases are at ca. 70 ± 10 yr, 190 ± 20 yr, 12 to 1 ka, 22 to 17 ka, 29 to 24 ka, and 40 to 32 ka. A maximum span for periods of pedogenesis at ca. 12 to 17 ka, 22 to 24 ka, and 29 to 32 ka was provided by bounding OSL ages, which broadly overlap with high stands of pluvial lakes and glacier advances in the central Andes. We infer that the added precipitation may reflect expansion of the Southern Hemisphere monsoon, associated with Northern Hemisphere Heinrich events, leading to episodes of significantly wetter conditions (>350 mm MAP) to at least 35° S. Most of the Holocene (12 ka to 0.8 ka) was characterized by sand sheet deposit under drier than present conditions (100-450 mm MAP), associated with Monte-type vegetation (shrub steppe). The latest two eolian depositional phases, occurred at ca. 190 and 70 yr ago, during the historic period with European settlement and are related to anthropogenic landscape disturbance, though the youngest phase was concomitant with 1930s drought. Wet conditions dominated since ca. AD 1970 with new lakes and rivers forming across this eolian terrain; an incongruous environmental response in reference to drier conditions for most of the Holocene.

The association constant of 5',8-cyclo-2'-deoxyguanosine with cytidine

Directory of Open Access Journals (Sweden)

Amedeo eCapobianco

2015-03-01

Full Text Available The association of 5',8-cyclo-2'-deoxyguanosine (cdG, a DNA tandem lesion, with its complementary base cytosine has been studied by voltammetry and NMR in chloroform, using properly silylated derivatives of the two nucleobases for increasing their solubilities. Both voltammetric data and NMR titrations indicated that the Watson-Crick complex of cytidine with cdG is weaker than that with guanosine, the difference being approximately of one order of magnitude between the two association constants.

Precision Deployable Mast for the SWOT KaRIn Instrument

Data.gov (United States)

National Aeronautics and Space Administration — Design and prototype a lightweight, precision-deployable mast for the Ka-band Radar Interferometer (KaRIn) antennas in the Surface Water and Ocean Topography (SWOT)...

The Potential for a Ka-band (32 GHz) Worldwide VLBI Network

Science.gov (United States)

Jacobs, C. S.; Bach, U.; Colomer, F.; Garcia-Miro, C.; Gomez-Gonzalez, J.; Gulyaev, S.; Horiuchi, S.; Ichikawa, R.; Kraus, A.; Kronschnabl, G.;

Snovanje in konstruiranje nadstreška za lahka gospodarska vozila

OpenAIRE

Čirić, Sebastijan

2015-01-01

Diplomska naloga opisuje primer snovanja in konstruiranja nadstreška za lahka gospodarska vozila. Naloga vsebuje statični preračun nadstreška sprogramom Scia Engineer 2011.1 in izdelavo modela nadstreška ter tehnično dokumentacijo v programu Pro Engineer 5.0. Rezultati statičnega preračuna so analizirane vrednosti povesa in napetosti.

The 13 ka Pelée-Type Dome Collapse at Nevado de Toluca Volcano, México.

Science.gov (United States)

D'Antonio, M.; Capra, L.; Sarocchi, D.; Bellotti, F.

2007-05-01

The Nevado de Toluca is an active volcano located in the central sector of the Trans-Mexican Volcanic Belt, 80 km southwest of Mexico City. Activity at this andesitic to dacitic stratovolcano began ca. 2.6 Ma ago. During the last 42 ka, the volcano has been characterized by different eruptive styles, including five dome collapses dated at 37, 32, 28, 26, and 13 ka and five Plinian eruptions at 42 ka, 36 ka, 21.7 ka, 12.1 ka and 10.5 ka. The 13 ka dome collapse is the youngest event of this type, and originated a 0.11 km3 block-and-ash flow deposit on the north-eastern sector of the volcano. The deposit consists of two facies: channel-like, 10 m thick, monolitologic, that is composed of up to five units, with decimetric dacitic clasts set in a sandy matrix; and a lateral facies that consists of a gray, sandy horizon, up to 4 m thick, with a 30 cm-thick surge layer at the base. The main component is a dacitic lava, with different degree of vesciculation, with mineral association of Pl-Hbl-Opx. Plagioclases show two different textures: in equilibrium, with normal zoning (core = An37-64.3, rim = An30.7-45.8) or with spongy cellular texture with inverse zoning (core = An38-43.5, rim = An45-51.2). Hornblende is normally light green, barren of oxidation. The rock matrix contains up to 53 perc. of glass with abundant microlites, indicating over-pressure on the crystallizing magma and a rapid expulsion. All these stratigraphic and petrographic features indicate that the dome was quickly extruded on the summit of the volcano, probably triggered by a magma mixing process, and its collapse was accompanied by an explosive component, being classified as a Pelée-type event.

Determination of dissociation constants or propionic acid and lactic acid (2-hydroxypropionic acid) by potentiometry and conductometry

International Nuclear Information System (INIS)

Saeeduddin; Khanzada, A.W.K.

2004-01-01

Dissociation constants of propionic acid and 2-hydroxypropionic acid (lactic acid) have been studied at different temperatures between 25 to 50 deg. C interval. Propionic acid is analyzed by conductometry while 2-hydroxypropionic acid is analyzed by potentiometry. Both investigated compounds are symmetrical carboxylic acids having same length of carbon chain but are markedly different in ionic behavior. We were interested to see how the hydroxyl group (-OH) induction in propionic acid affects on pKa values of 2-hydroxypropionic acid. We observed that as temperature increases pKa values increase. The increase is observed for both the investigated compounds. PKa values of 2-hydroxypropionic acid are lower as compared to propionic acid because of electron withdrawing (-OH). (author)

Proposal for the Award of a Contract for the Supply of 13 kA and 20.5 kA, 18 V Switched-Mode Power Converters for the LHC

CERN Document Server

2003-01-01

This document concerns the award of a contract for the supply of 13 kA and 20.5 kA, 18 V switched-mode power converters using sub-converters of 3.25 kA. Following a market survey (MS-2866/SL/LHC) carried out among 81 firms in seventeen Member States and a call for tenders for prototypes (IT-2919/SL/LHC) sent on 11 June 2001, a call for tenders for the supply of the pre-series and series of 13 kA and 20.5 kA, 18 V switched-mode power converters both using sub-converters of 3.25 kA was sent to two firms on 17 September 2002. The Finance Committee is invited to agree to the negotiation of a contract with TRANSTECHNIK (DE), the only firm that has delivered a successfully qualifying prototype, for the supply of eighteen 13 kA and one 20.5 kA, 18 V switched-mode power converters and spares for a total amount of 4 607 731 euros (6 747 300 Swiss francs), not subject to revision. The rate of exchange used is that stipulated in the tender. The firm has indicated the following distribution by country of the contract val...

Developing hybrid approaches to predict pKa values of ionizable groups

Science.gov (United States)

Witham, Shawn; Talley, Kemper; Wang, Lin; Zhang, Zhe; Sarkar, Subhra; Gao, Daquan; Yang, Wei

2011-01-01

Accurate predictions of pKa values of titratable groups require taking into account all relevant processes associated with the ionization/deionization. Frequently, however, the ionization does not involve significant structural changes and the dominating effects are purely electrostatic in origin allowing accurate predictions to be made based on the electrostatic energy difference between ionized and neutral forms alone using a static structure. On another hand, if the change of the charge state is accompanied by a structural reorganization of the target protein, then the relevant conformational changes have to be taken into account in the pKa calculations. Here we report a hybrid approach that first predicts the titratable groups, which ionization is expected to cause conformational changes, termed “problematic” residues, then applies a special protocol on them, while the rest of the pKa’s are predicted with rigid backbone approach as implemented in multi-conformation continuum electrostatics (MCCE) method. The backbone representative conformations for “problematic” groups are generated with either molecular dynamics simulations with charged and uncharged amino acid or with ab-initio local segment modeling. The corresponding ensembles are then used to calculate the pKa of the “problematic” residues and then the results are averaged. PMID:21744395

Computing pKa Values with a Mixing Hamiltonian Quantum Mechanical/Molecular Mechanical Approach.

Science.gov (United States)

Liu, Yang; Fan, Xiaoli; Jin, Yingdi; Hu, Xiangqian; Hu, Hao

2013-09-10

Accurate computation of the pKa value of a compound in solution is important but challenging. Here, a new mixing quantum mechanical/molecular mechanical (QM/MM) Hamiltonian method is developed to simulate the free-energy change associated with the protonation/deprotonation processes in solution. The mixing Hamiltonian method is designed for efficient quantum mechanical free-energy simulations by alchemically varying the nuclear potential, i.e., the nuclear charge of the transforming nucleus. In pKa calculation, the charge on the proton is varied in fraction between 0 and 1, corresponding to the fully deprotonated and protonated states, respectively. Inspired by the mixing potential QM/MM free energy simulation method developed previously [H. Hu and W. T. Yang, J. Chem. Phys. 2005, 123, 041102], this method succeeds many advantages of a large class of λ-coupled free-energy simulation methods and the linear combination of atomic potential approach. Theory and technique details of this method, along with the calculation results of the pKa of methanol and methanethiol molecules in aqueous solution, are reported. The results show satisfactory agreement with the experimental data.

Design considerations on a sparse array antenna for Ka-band spaceborne SAR applications

NARCIS (Netherlands)

Jacobs, S.; Bekers, D.; Monni, S.; Otten, M.; Van Rossum, W.; Gerini, G.; Germani, C.; Fortini, D.; Toso, G.

2015-01-01

This contribution addresses the problem of designing a sparse active array antenna for spaceborne SAR applications at Ka-band. The main driver for the design is limiting the recurring manufacturing costs associated to the number of active modules, while preserving main performance and insuring a

Origin of the pKa shift of the catalytic lysine in acetoacetate decarboxylase.

OpenAIRE

Ishikita, Hiroshi

2010-01-01

The pKa value of Lys115, the catalytic residue in acetoacetate decarboxylate, was calculated using atomic coordinates of the X-ray crystal structure with consideration of the protonation states of all titratable sites in the protein. The calculated pKa value of Lys115 (pKa(Lys115)) was unusually low (approximately 6) in agreement with the experimentally measured value. Although charged residues impact pKa(Lys115) considerably in the native protein, the significant pKa(Lys115) downshift in the...

Determination, at equilibrium, of association constants of labelled or unlabelled ligands by a non-graphical method

International Nuclear Information System (INIS)

Goertz, G.; Longchampt, J.; Crepy, O.; Judas, O.; Jayle, M.-F.

1976-01-01

Determination, at equilibrium of association constants of labelled or unlabelled ligands by a non-graphical method are described. This work deals with the determination of association constants at equilibrium by a non-graphical method in binding systems containing one specific receptor. Equations have been derived from that originally described by Lea (Biochim. Biophys. Acta, 322, 68-74), the terms of which are obtained from the data of simple displacement curves of a bound radioactive ligand by unlabelled competitors identical or different in nature. By knowing the function relating the variations of the bound ligand (B) to the affinity constant (Ksub(i)) and the quantity (Msub(i)) of competitor for a given system, it is possible to calculate any of these parameters when the two others are measured. Thus, it becomes easy to compare the relative affinities of different receptors for the same ligand or that of one receptor for various labelled or unlabelled ligands. Furthermore, theoretical displacement curves can be drawn and compared to experimental data, only when knowing the affinity constant of a specific binding system in given conditions. These modes of calculation have been tested in a study of interactions between various steroids and a fraction of human serum proteins precipitated by ammonium sulfate (30-45%) and containing the sex hormone-binding globulin. Association constants thus obtained agree well with those reported in the literature and determined by graphical procedures

Computing pKa Values in Different Solvents by Electrostatic Transformation.

Science.gov (United States)

Rossini, Emanuele; Netz, Roland R; Knapp, Ernst-Walter

2016-07-12

We introduce a method that requires only moderate computational effort to compute pKa values of small molecules in different solvents with an average accuracy of better than 0.7 pH units. With a known pKa value in one solvent, the electrostatic transform method computes the pKa value in any other solvent if the proton solvation energy is known in both considered solvents. To apply the electrostatic transform method to a molecule, the electrostatic solvation energies of the protonated and deprotonated molecular species are computed in the two considered solvents using a dielectric continuum to describe the solvent. This is demonstrated for 30 molecules belonging to 10 different molecular families by considering 77 measured pKa values in 4 different solvents: water, acetonitrile, dimethyl sulfoxide, and methanol. The electrostatic transform method can be applied to any other solvent if the proton solvation energy is known. It is exclusively based on physicochemical principles, not using any empirical fetch factors or explicit solvent molecules, to obtain agreement with measured pKa values and is therefore ready to be generalized to other solute molecules and solvents. From the computed pKa values, we obtained relative proton solvation energies, which agree very well with the proton solvation energies computed recently by ab initio methods, and used these energies in the present study.

Comparison of Predicted pKa Values for Some Amino-Acids, Dipeptides and Tripeptides, Using COSMO-RS, ChemAxon and ACD/Labs Methods Comparaison des valeurs de pKa de quelques acides aminés, dipeptides et tripeptides, prédites en utilisant les méthodes COSMO-RS, ChemAxon et ACD/Labs

Directory of Open Access Journals (Sweden)

Toure O.

2013-05-01

Full Text Available Liquid-phase pKa values play a key role in food science. Chemical properties of molecules depend largely on whether they are ionized or not. Most organic molecules are capable of gaining and/or losing a proton in aqueous solutions. Proton transfer most. frequently occurs between water and any ionizable atom of the organic molecule. The molecule’s response to profanation or deprotonation depends significantly on the site that was disturbed by proton transfer. Partial charge distribution in the molecule also varies with protonation of the acidlbase active sites. Then it can he used to determine the pKa of a molecule. First, we use the COSMO-RS method, a combination of the quantum chemical dielectric continuum solvation model COSMO with a statistical thermodynamics treatment fin- more Realistic Solvation (RS simulations, for the direct prediction of pKa constants of about 50 molecules (amino-acids, dipeptides and tripeptides. Then, we compare our results with experimental data and the pKa values predicted using two other methods. We used respectively the ChemAxon method using a program based on the calculation of partial charge of atoms in the molecule and the ACD/Labs method that enables to calculate single pKa values. for all possible dissociation centers when the rest of the molecule is considered neutral, using an internal database containing chemical structures and their experimental pKa values. The averaged Root Mean Square Error (RMSE of the predicted pKa values for each method compared to experimental results were respectively 0.596 for COSMO-RS, 0.445 for ChemAxon and 0.490 for ACD/Labs. While ACDILabs and ChemAxon are parameterized using a large set ofexperimental data (including several of the studied molecules, the COSMO- RS method was used in a fully predictive way. Regarding these results, COSMO-RS appears as a promising method to predict the pKa values of molecules of interest in food science with scarce available pKa values such

Ka-band microwave generation using the Smith-Purcell effect

International Nuclear Information System (INIS)

Ekdahl, C.A.; Davis, H.A.

1983-01-01

The CERETRON microwave generator concept relies on the conversion of intense relativistic electron beam (REB) energy into highpower microwave emission through the Smith-Purcell effect. We report initial results from experiments with the production of Ka-band Smith-Purcell radiation generated by a 50-kA, 2.8-MeV beam propagated through a cylindrical transmission grating with lambda 0 = 1 cm. These experiments were performed without a quasi-optical resonator, and the output was limited by breakdown of the grating and by limited access through the 90-kG magnet coil. Nevertheless, the measured power output from these initial experiments was about 7 kW in the Ka band

Studying NASA's Transition to Ka-Band Communications for Low Earth Orbit

Science.gov (United States)

Chelmins, David T.; Reinhart, Richard C.; Mortensen, Dale; Welch, Bryan; Downey, Joseph; Evans, Michael

2014-01-01

As the S-band spectrum becomes crowded, future space missions will need to consider moving command and telemetry services to Ka-band. NASA's Space Communications and Navigation (SCaN) Testbed provides a software-defined radio (SDR) platform that is capable of supporting investigation of this service transition. The testbed contains two S-band SDRs and one Ka-band SDR. Over the past year, SCaN Testbed has demonstrated Ka-band communications capabilities with NASAs Tracking and Data Relay Satellite System (TDRSS) using both open- and closed-loop antenna tracking profiles. A number of technical areas need to be addressed for successful transition to Ka-band. The smaller antenna beamwidth at Ka-band increases the criticality of antenna pointing, necessitating closed loop tracking algorithms and new techniques for received power estimation. Additionally, the antenna pointing routines require enhanced knowledge of spacecraft position and attitude for initial acquisition, versus an S-band antenna. Ka-band provides a number of technical advantages for bulk data transfer. Unlike at S-band, a larger bandwidth may be available for space missions, allowing increased data rates. The potential for high rate data transfer can also be extended for direct-to-ground links through use of variable or adaptive coding and modulation. Specific examples of Ka-band research from SCaN Testbeds first year of operation will be cited, such as communications link performance with TDRSS, and the effects of truss flexure on antenna pointing.

Kanegelo ya Nimirode: Re lebelela diphihlelelo t�a gagwe ka lefsa

Directory of Open Access Journals (Sweden)

Elelwani B. Farisani

2011-03-01

Full Text Available Kanegelo ya Hama/Nimirode e �omi�it�we go gatelela Bathobaso ba Afrika-Borwa le ba Amerika. Taodi�wana ye e lekola Nimirode ka lefsa le go t�ea magato a go bu�et�a seriti sa gagwe le sa Bathobaso sekeng.Seo se tlo dirwa ka dikgato t�e tlhano ka mo tlase. Sa mathomo, re tlo lekola dimelo t�a bana ba Noage, go kwe�i�a Nimirode, yo e lego yena �edi ye kgolo ya taodi�wana ye. Sa bobedi re tlo lebelela ka fao bangwadi ba bangwe ba t�welet�ago seswant�ho sa go befa sa Nimirode. Sa boraro, re tlo sekaseka tiri�o ya kanegelo ya Hama/Nimirode go gatelela le go dira Bathobaso makgoba. Sa bone, re tlo sekaseka diphihlelelo le dikatlego t�a Nimirode. Mo re tlo tsepelela diphihlelelo t�a gagwe t�e tharo t�e kgolo bjalo ka go ba mmu�i wa maemo, motsomi yo maatla le moagi. Nepo ya karolo ye ke go ganet�ana le tshekatsheko ya go se be botse ye e nepilwego Nimirode nakong ya go feta. Re tlo tlalelet�a ka go fa tshekatsheko ye e tebilego ya thogako godimo ga Hama/Ku�e/Nimirode. Sa bohlano, ebile e le sa mafelelo, re tlo t�welet�a nyanyeng bohlokwa bja kanegelo ya Nimirode go bao ba bego ba gatelet�we le go ba makgoba ka baka la temana ye. Re tlo nepi�a Afrika-Borwa.

Food safety assessment of Cry8Ka5 mutant protein using Cry1Ac as a control Bt protein.

Science.gov (United States)

Farias, Davi Felipe; Viana, Martônio Ponte; Oliveira, Gustavo Ramos; Santos, Vanessa Olinto; Pinto, Clidia Eduarda Moreira; Viana, Daniel Araújo; Vasconcelos, Ilka Maria; Grossi-de-Sa, Maria Fátima; Carvalho, Ana Fontenele Urano

2015-07-01

Cry8Ka5 is a mutant protein from Bacillus thuringiensis (Bt) that has been proposed for developing transgenic plants due to promising activity against coleopterans, like Anthonomus grandis (the major pest of Brazilian cotton culture). Thus, an early food safety assessment of Cry8Ka5 protein could provide valuable information to support its use as a harmless biotechnological tool. This study aimed to evaluate the food safety of Cry8Ka5 protein following the two-tiered approach, based on weights of evidence, proposed by ILSI. Cry1Ac protein was used as a control Bt protein. The history of safe use revealed no convincing hazard reports for Bt pesticides and three-domain Cry proteins. The bioinformatics analysis with the primary amino acids sequence of Cry8Ka5 showed no similarity to any known toxic, antinutritional or allergenic proteins. The mode of action of Cry proteins is well understood and their fine specificity is restricted to insects. Cry8Ka5 and Cry1Ac proteins were rapidly degraded in simulated gastric fluid, but were resistant to simulated intestinal fluid and heat treatment. The LD50 for Cry8Ka5 and Cry1Ac was >5000 mg/kg body weight when administered by gavage in mice. Thus, no expected relevant risks are associated with the consumption of Cry8Ka5 protein. Copyright © 2015 Elsevier Ltd. All rights reserved.

Updating and test on 12 kA HTSCL for Russia JINR

International Nuclear Information System (INIS)

Zhou, Tingzhi; Ding, K; Liu, C; Xu, C; Feng, H; Wu, H; Liu, X; Song, Y

2014-01-01

The Joint Institute for Nuclear Research (JINR) started manufacture and test of superconducting magnets for the new accelerator complex Nuclotron-based Ion Collider fAcility (NICA). A pair of current leads rated 12 kA was developed for cold testing of the magnets in 2012. The operation of the facility needs ∼350 leads rated from 100 A to 12 kA to convey current for the magnets. After the test of the pair of 12 kA leads in JINR a contract of supplying 3 pairs of 12 kA high temperature superconducting current leads (HTSCLs) were signed to ASIPP this year. In this paper the design updating and test of the current leads are introduced.

Probability of burn-through of defective 13 kA splices at increased energy levels

CERN Document Server

Verweij, A

2011-01-01

In many 13 kA splices in the machine there is a lack of bonding between the superconducting cable and the stabilising copper along with a bad contact between the bus stabiliser and the splice stabiliser. In case of a quench of such a defective splice, the current cannot bypass the cable through the copper, hence leading to excessive local heating of the cable. This may result in a thermal runaway and burn-through of the cable in a time smaller than the time constant of the circuit. Since it is not possible to protect against this fast thermal run-away, one has to limit the current to a level that is small enough so that a burn-through cannot occur. Prompt quenching of the joint, and quenching due to heat propagation through the bus and through the helium are considered. Probabilities for joint burn-through are given for the RB circuit for beam energies of 3.5, 4 and 4.5 TeV, and a decay time constant of the RB circuit of 50 and 68 s.

Historical review of bryological research in Fruška Gora Mt. (Serbia

Directory of Open Access Journals (Sweden)

Ilić Miloš M.

2016-01-01

Full Text Available Fruška Gora is a mountain located in the southern part of Pannonian plane and it is poorly bryologicaly investigated as well as most parts of Serbia. First data on bryophytes, for this region, were published in 1949 by Teodor Soška in his paper Pregled mahovina i lišajeva u okolini Beograda (Review of mosses and lichens in the vicinity of Belgrade. Soška listed 34 species of mosses and 8 liverworts species for this region. Later, in 1955, Zlatko Pavletić in his capital work Prodromus flore briofita Jugoslavije (Prodromus of Yugoslavian bryophyte flora, stated 26 moss species and 3 liverwort species, without indicating specific localities, but all of them were Soška’s original results. In 1966, the second botanist with original findings of bryophytes on Fruška Gora was Popović, who recorded 2 liverwort and 19 moss species, for this mountain, also without specific localities. By far, the most comprehensive data were given by Cvetić and Sabovljević in 2004. Their study A contribution to the bryophyte flora of Fruška Gora (Vojvodina, Serbia counted total number of 118 mosses and 14 liverworts, on 16 localities within National park Fruška Gora. The latest study on bryophytes of Fruška Gora was in 2013, and it is the first and so far, the last study of bryophyte assemblages on grasslands. Authors of this paper recorded 18 species of mosses from 29 releveé. Complete bryophyte flora of Fruška Gora is still unknown. Considering the fact that this is the region with high biodiversity, dense hydrological network and a rather complex geology, Fruška Gora certainly deserves further bryological researches.

Ka-band waveguide rotary joint

KAUST Repository

Yevdokymov, Anatoliy; Sirenko, Kostyantyn; Kryzhanovskiy, Volodymyr; Pazynin, Vadim

2013-01-01

The authors present a design of a waveguide rotary joint operating in Ka-band with central frequency of 33 GHz, which also acts as an antenna mount. The main unit consists of two flanges with a clearance between them; one of the flanges has three

Amobilisasi Sel Bacillus licheniformis KA-08 dalam Menghasilkan Keratinase Termostabil

Directory of Open Access Journals (Sweden)

Anthoni Agustien

2012-10-01

Full Text Available Isolate local Bacillus licheniformis KA-08 known extracellular thermostable keratinase producers. Scale up of thermostable keratinase production can be with cells immobilized. The objective of the research is to thermostable keratinase production of B. licheniformis KA-08 cells immobilization. Thermostable keratinase activities were determined with modification of Brandelli and Riffel method. Protein concentration of enzyme determined with Lowry method. Immobilization of cells by Ca-alginate matrix with Adinarayana method, alginate concentration and amount of alginate bead effects with Beshay method. The result extracellular thermostable keratinase of B. licheniformis KA-08 cells immobilized was maximum produced at 12 times incubation with activity as 9.25 U/mg. Three percent alginate has optimum activity. Three hundred alginate beads has optimum activity. Cells immobilized ofB. licheniformis KA-08 has scale up of thermostable keratinase activity at 2 times than free cells. Thermostable keratinase produced by cell immobilized was nine cycles.

A 20-15 ka high-resolution paleomagnetic secular variation record from Black Sea sediments - no evidence for the 'Hilina Pali excursion'?

Science.gov (United States)

Liu, Jiabo; Nowaczyk, Norbert R.; Frank, Ute; Arz, Helge W.

2018-06-01

A comprehensive magnetostratigraphic investigation on sixteen sediment cores from the southeastern Black Sea yielded a very detailed high-quality paleosecular variation (PSV) record spanning from 20 to 15 ka. The age models are based on radiocarbon dating, stratigraphic correlation, and tephrochronology. Further age constraints were obtained by correlating four meltwater events, described from the western Black Sea, ranging in age from about 17 to 15 ka, with maxima in K/Ti ratios, obtained from X-ray fluorescence (XRF) scanning, and minima in S-ratios, reflecting increased hematite content, in the studied cores. Since the sedimentation rates in the investigated time window are up to 50 cm ka-1, the obtained PSVs records enabled a stacking using 50-yr bins. A directional anomaly at 18.5 ka, associated with pronounced swings in inclination and declination, as well as a low in relative paleointensity (rPI), is probably contemporaneous with the Hilina Pali excursion, originally reported from Hawaiian lava flows. However, virtual geomagnetic poles (VGPs) calculated from Black Sea sediments are not located at latitudes lower than 60°N, which denotes normal, though pronounced secular variations. During the postulated Hilina Pali excursion, the VGPs calculated from Black Sea data migrated clockwise only along the coasts of the Arctic Ocean from NE Canada (20.0 ka), via Alaska (18.6 ka) and NE Siberia (18.0 ka) to Svalbard (17.0 ka), then looping clockwise through the Eastern Arctic Ocean.

AltiKa: a Ka-band Altimetry Payload and System for Operational Altimetry during the GMES Period

Directory of Open Access Journals (Sweden)

Jacques Verron

2006-03-01

Full Text Available This paper describes the Ka-band altimetry payload and system that has beenstudied for several years by CNES, ALCATEL SPACE and some science laboratories.Altimetry is one of the major elements of the ocean observing system to be madesustainable through the GEOSS (Global Earth Observation System of Systems and GMES(Global Monitoring of the Environment and Security programs. A short review of somemission objectives to be fulfilled in terms of mesoscale oceanography in the frame of theGEOSS and GMES programs is performed. To answer the corresponding requirements, theapproach consisting in a constellation of nadir altimeter is discussed. A coupled Ka-bandaltimeter-radiometer payload is then described; technical items are detailed to explain howthis payload shall meet the science and operational requirements, and expectedperformances are displayed. The current status of the payload development and flightperspectives are given.

Phototransformation rate constants of PAHs associated with soot particles

International Nuclear Information System (INIS)

Kim, Daekyun; Young, Thomas M.; Anastasio, Cort

2013-01-01

Photodegradation is a key process governing the residence time and fate of polycyclic aromatic hydrocarbons (PAHs) in particles, both in the atmosphere and after deposition. We have measured photodegradation rate constants of PAHs in bulk deposits of soot particles illuminated with simulated sunlight. The photodegradation rate constants at the surface (k p 0 ), the effective diffusion coefficients (D eff ), and the light penetration depths (z 0.5 ) for PAHs on soot layers of variable thickness were determined by fitting experimental data with a model of coupled photolysis and diffusion. The overall disappearance rates of irradiated low molecular weight PAHs (with 2–3 rings) on soot particles were influenced by fast photodegradation and fast diffusion kinetics, while those of high molecular weight PAHs (with 4 or more rings) were apparently controlled by either the combination of slow photodegradation and slow diffusion kinetics or by very slow diffusion kinetics alone. The value of z 0.5 is more sensitive to the soot layer thickness than the k p 0 value. As the thickness of the soot layer increases, the z 0.5 values increase, but the k p 0 values are almost constant. The effective diffusion coefficients calculated from dark experiments are generally higher than those from the model fitting method for illumination experiments. Due to the correlation between k p 0 and z 0.5 in thinner layers, D eff should be estimated by an independent method for better accuracy. Despite some limitations of the model used in this study, the fitted parameters were useful for describing empirical results of photodegradation of soot-associated PAHs. - Highlights: ► PAHs on soot were evaluated by a model of coupled photolysis and diffusion. ► Photodegradation rate at the surface, diffusion coefficient, and light penetration path were determined. ► Low MW PAHs were influenced by fast photodegradation and fast diffusion. ► High MW PAHs were controlled either by slow

Deployable Ka-Band Reflectarray, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Tyvak, in collaboration with UCLA, proposes a novel approach to the challenge of creating a large reflector for Ka-band high data rate links. We propose to attach...

A Novel Ku-Band/Ka-Band and Ka-Band/E-Band Multimode Waveguide Couplers for Power Measurement of Traveling-Wave Tube Amplifier Harmonic Frequencies

Science.gov (United States)

Wintucky, Edwin G.; Simons, Rainee N.

2015-01-01

This paper presents the design, fabrication and test results for a novel waveguide multimode directional coupler (MDC). The coupler, fabricated from two dissimilar frequency band waveguides, is capable of isolating power at the second harmonic frequency from the fundamental power at the output port of a traveling-wave tube (TWT) amplifier. Test results from proof-of-concept demonstrations are presented for a Ku-band/Ka-band MDC and a Ka-band/E-band MDC. In addition to power measurements at harmonic frequencies, a potential application of the MDC is in the design of a satellite borne beacon source for atmospheric propagation studies at millimeter-wave (mm-wave) frequencies (Ka-band and E-band).

Gauss-Bonnet coupling constant as a free thermodynamical variable and the associated criticality

International Nuclear Information System (INIS)

Xu, Wei; Xu, Hao; Zhao, Liu

2014-01-01

The thermodynamic phase space of Gauss-Bonnet (GB) AdS black holes is extended, taking the inverse of the GB coupling constant as a new thermodynamic pressure P GB . We studied the critical behavior associated with P GB in the extended thermodynamic phase space at fixed cosmological constant and electric charge. The result shows that when the black holes are neutral, the associated critical points can only exist in five dimensional GB-AdS black holes with spherical topology, and the corresponding critical exponents are identical to those for the Van der Waals system. For charged GB-AdS black holes, it is shown that there can be only one critical point in five dimensions (for black holes with either spherical or hyperbolic topologies), which also requires the electric charge to be bounded within some appropriate range; while in d < 5 dimensions, there can be up to two different critical points at the same electric charge, and the phase transition can occur only at temperatures which are not in between the two critical values. (orig.)

Ravimiturg peaks ka sel aastal jõudsalt kasvama / Violetta Riidas

Index Scriptorium Estoniae

Riidas, Violetta

2008-01-01

Ilmunud ka: Äripäev 30. apr. lk. 16. Eelmise aasta ravimituru kasv jätkub tõenäoliselt ka sel aastal, kuna negatiivne riigieelarve ravimihüvitisi ei kärbi. Vt. samas: Võrdlus: Ravimituru jaotus haiglaapteekide ning teiste asutuste vahel peamiste ATC rühmade lõikes, 2007

A Ka-Band Celestial Reference Frame with Applications to Deep Space Navigation

Science.gov (United States)

Jacobs, Christopher S.; Clark, J. Eric; Garcia-Miro, Cristina; Horiuchi, Shinji; Sotuela, Ioana

2011-01-01

The Ka-band radio spectrum is now being used for a wide variety of applications. This paper highlights the use of Ka-band as a frequency for precise deep space navigation based on a set of reference beacons provided by extragalactic quasars which emit broadband noise at Ka-band. This quasar-based celestial reference frame is constructed using X/Ka-band (8.4/32 GHz) from fifty-five 24-hour sessions with the Deep Space Network antennas in California, Australia, and Spain. We report on observations which have detected 464 sources covering the full 24 hours of Right Ascension and declinations down to -45 deg. Comparison of this X/Ka-band frame to the international standard S/X-band (2.3/8.4 GHz) ICRF2 shows wRMS agreement of approximately 200 micro-arcsec in alpha cos(delta) and approximately 300 micro-arcsec in delta. There is evidence for systematic errors at the 100 micro-arcsec level. Known errors include limited SNR, lack of instrumental phase calibration, tropospheric refraction mis-modeling, and limited southern geometry. The motivation for extending the celestial reference frame to frequencies above 8 GHz is to access more compact source morphology for improved frame stability and to support spacecraft navigation for Ka-band based NASA missions.

Determination of the acidity constants of neutral red and bromocresol green by solution scanometric method and comparison with spectrophotometric results

Directory of Open Access Journals (Sweden)

Ardeshir Shokrollahi

2016-03-01

The method is based on scanning cells containing the indicator solution with a scanner, and analyzing the color of each cell with a software written in visual basic (VB 6 media to red, green and blue values. The cells were made by making holes in the Plexiglas® sheet. Also, the acidity constants of the neutral red and bromocresol green indicators were studied with spectrophotometrically. HypSpec program has been applied for the estimation of pKa values based on spectrophotometric data. The agreement between obtained pKa values by solution scanometric, spectrophotometric method and values reported in the literature demonstrates the utility of the method here used. Also the HySS 2009 program was applied for drawing of the corresponding distribution diagrams.

Hydroclimatic variability in loess δDwax records from the central Chinese Loess Plateau over the past 250 ka

Science.gov (United States)

Wang, Zheng; An, Zhisheng; Liu, Zhonghui; Qiang, Xiaoke; Zhang, Fan; Liu, Weiguo

2018-04-01

This study reports hydrogen isotopic records from the central Chinese Loess Plateau (CLP) over the past 250 ka. After eliminating the influence of ice and local temperatures, the δDwax records extracted from two loess sites at Xifeng and Luochuan can be taken to represent arid/humid alternations in the hydrological environment in this marginal Asian Summer Monsoon (ASM) region; they also contain integrated information on summer precipitation patterns and the corresponding responses to these changes by predominant vegetation cover types. These arid/humid alternations show 100 ka, 40 ka and 20 ka cycles. An increase in precipitation in association with an enhanced summer monsoon has historically been taken to be the major factor driving a humid environment in the central CLP. However, hydroclimatic changes in δDwax records differ for the central CLP, central China and southern China. Over a 20 ka cycle, the influence of solar insolation on hydroclimatic changes can be shown to be consistent throughout the central CLP. However, changes in the relative location of the land and sea may have caused different hydroclimatic responses between southern China and the central CLP on a glacial-interglacial scale. The hydroclimatic variability in the central CLP would suggest that an enhanced summer monsoon due to climatic warming is the key to understanding decreased drought degree in this marginal monsoonal region.

Vesnička tesařů Ostrovec (Johannesdörfl)

Czech Academy of Sciences Publication Activity Database

Vlček, Pavel

6/7, 2016/2017 (2017), s. 39-46 ISSN 1805-8906 R&D Projects: GA MK DG16P02H023 Keywords : Ostrovec (Johannesdörfl) * carpenters * church od St. John the Baptist * František Maxmilián Kaňka * Johann Mathes Spiess * Anton Haffenecker Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Architectural design

Determination of lactic acid bacteria in Kaºar cheese and ...

African Journals Online (AJOL)

Lactic acid bacteria (LAB) arise in Kaşar cheese, an artisanal pasta filata cheese produced in Turkey from raw milk without starter addition or pasteurized milk with starter culture. In this study, 13 samples of Kaşar cheese that were produced from raw milk were used as reference materials. LAB were characterized by using ...

Elevation Change Derived from SARAL/ALtiKa Altimetric Mission: Quality Assessment and Performance of the Ka-Band

Directory of Open Access Journals (Sweden)

Quanming Yang

2018-04-01

Full Text Available The waveform retracking algorithm is a key factor that affects the accuracy of elevation change from satellite altimetry over an ice sheet. The elevation change results from four waveform retracker algorithms (ICE1/ICE2/Sea Ice/OCEAN provided by the Satellite with ARgos and ALtiKa (SARAL/ALtiKa data were compared using repeated SARAL data between March 2013 and April 2016 to determine the optimal retracker in the crossovers of descending and ascending orbits over a Greenland ice sheet (GrIS. The ICE1 provided slightly better results than the three other algorithms with the lowest standard deviation (SD of 0.30 m year−1. Further comparison was also conducted between the Satellite with ARgos and ALtiKa (SARAL and Operation ICEBridge laser data, thereby indicating that ICE1 was the best retracker with an Root Mean Square Error (RMSE of 0.43 m year−1. The distribution of elevation change rate and uncertainties over Greenland from SARAL were presented using the selected ICE1 retracker with a volume loss of 40 ± 12 km3 year−1. This volume loss did not include the fast-changing coastal areas of the GrIS. A large thinning was observed in Jakobshavn Isbræ, and a trend that extended far inland was also found from 2013–2016. Furthermore, a melting ice sheet was observed in the large areas northwest over the GrIS.

X/Ka Celestial Frame Improvements: Vision to Reality

Science.gov (United States)

Jacobs, C. S.; Bagri, D. S.; Britcliffe, M. J.; Clark, J. E.; Franco, M. M.; Garcia-Miro, C.; Goodhart, C. E.; Horiuchi, S.; Lowe, S. T.; Moll, V. E.;

GRAPHICAL DETERMINATION OF DISSOCIATION CONSTANT ...

African Journals Online (AJOL)

DR. AMINU

conform to the general equation of straight – line graph; y = mx + c, where y = pH, m = slope, x = log. [HA]/[A] and C = intercept = pKa. Thus the pKa is obtained as the intercept of the graph of pH versus – log [HA]/[A] as shown in Figures 1,2 and 3 for glycine, alanine and valine respectively. The values obtained were 9.87 ...

CONCENTRATION DEPENDENCE OF STERN LAYER CAPACITANCES AND SURFACE EQUILIBRIUM CONSTANTS IN SILICA-BASED NANOFLUIDIC CHANNELS

DEFF Research Database (Denmark)

Andersen, Mathias Bækbo; Frey, J.; Bruus, Henrik

2010-01-01

Fundamental understanding of the unique physics at the solid-liquid interface in nanofluidic channels is essential for the advancement of basic scientific knowledge and the development of novel applications for pharmaceuticals, environmental health and safety, energy harvesting and biometrics [1......]. The current models used to describe surface phenomena in nanofluidics can differ by orders of magnitude from experimentally measured values [2]. To mitigate the discrepancies, we hypothesize that the Stern-layer capacitance Cs and the surface equilibrium constants pKa, vary with the composition of the solid...

KaBOB: ontology-based semantic integration of biomedical databases.

Science.gov (United States)

Livingston, Kevin M; Bada, Michael; Baumgartner, William A; Hunter, Lawrence E

2015-04-23

The ability to query many independent biological databases using a common ontology-based semantic model would facilitate deeper integration and more effective utilization of these diverse and rapidly growing resources. Despite ongoing work moving toward shared data formats and linked identifiers, significant problems persist in semantic data integration in order to establish shared identity and shared meaning across heterogeneous biomedical data sources. We present five processes for semantic data integration that, when applied collectively, solve seven key problems. These processes include making explicit the differences between biomedical concepts and database records, aggregating sets of identifiers denoting the same biomedical concepts across data sources, and using declaratively represented forward-chaining rules to take information that is variably represented in source databases and integrating it into a consistent biomedical representation. We demonstrate these processes and solutions by presenting KaBOB (the Knowledge Base Of Biomedicine), a knowledge base of semantically integrated data from 18 prominent biomedical databases using common representations grounded in Open Biomedical Ontologies. An instance of KaBOB with data about humans and seven major model organisms can be built using on the order of 500 million RDF triples. All source code for building KaBOB is available under an open-source license. KaBOB is an integrated knowledge base of biomedical data representationally based in prominent, actively maintained Open Biomedical Ontologies, thus enabling queries of the underlying data in terms of biomedical concepts (e.g., genes and gene products, interactions and processes) rather than features of source-specific data schemas or file formats. KaBOB resolves many of the issues that routinely plague biomedical researchers intending to work with data from multiple data sources and provides a platform for ongoing data integration and development and for

A ˜50 ka record of monsoonal variability in the Darjeeling foothill region, eastern Himalayas

Science.gov (United States)

Ghosh, Ruby; Bera, Subir; Sarkar, Anindya; Paruya, Dipak Kumar; Yao, Yi-Feng; Li, Cheng-Sen

2015-04-01

Pollen, phytoliths and δ 13C signatures of soil organic matter from two fluvial sedimentary sequences of the Darjeeling foothill region, eastern Himalayas are used to portray palaeoclimatic oscillations and their impact on regional plant communities over the last ˜50 ka. Quantitative palaeoclimate estimation using coexistence approach on pollen data and other proxies indicate significant oscillations in precipitation during the late part of MIS 3 (46.4-25.9 ka), early and middle part of MIS 2 (25.9-15.6 ka), and 5.4 to 3.5 ka. Middle to late MIS 3 (ca 46.4-31 ka.) was characterized by a comparatively low monsoonal activity and slightly higher temperature than that during ca 31 ka onwards. Simultaneous expansion of deciduous trees and chloridoid grasses also imply a drier and warmer phase. Between 31 and 22.3 ka (late MIS 3 to mid-MIS 2), higher precipitation and a slightly cooler temperature led to an increase in evergreen elements over deciduous taxa and wet-loving panicoid grasses over dry-loving chloridoid grasses than earlier. After ca 22.3 ka, shrinking of forest cover, expansion of C4 chloridoid grasses, Asteraceae and Cheno-ams in the vegetation with lowering of temperature and precipitation characterized the onset of the LGM which continued till 18.3 ka. End of the LGM is manifested by a restoration in the forest cover and in the temperature and precipitation regime. Later, during 5.4 to 4.3 ka, a strong monsoonal activity supported a dense moist evergreen forest cover that subsequently declined during 4.3 to 3.5 ka. A further increase in deciduous elements and non-arboreals might be a consequence of reduced precipitation and higher temperature during this phase. A comparison between monsoonal rainfall, MAT and palaeoatmospheric CO2 with floral dynamics since last ˜50 ka indicates that these fluctuations in plant succession were mainly driven by monsoonal variations.

Jaapani edumetoodika ka Eestis / Merike Lees

Index Scriptorium Estoniae

Lees, Merike, 1976-

2004-01-01

Ilmunud ka: Delovõje Vedomosti 17. nov. lk. 28. Tootmissfääris kasutatavast Jaapani 20 võtme metoodikast loodab ettevõttele kasu saada lehtmetalli töötleva AS-i Favor Metaform nõukogu esimees Almar Proosi. Lisa: Mis on 20 võtit?

Highly Perturbed pKa Values in the Unfolded State of Hen Egg White Lysozyme

OpenAIRE

Bradley, John; O'Meara, Fergal; Farrell, Damien; Nielsen, Jens Erik

2012-01-01

The majority of pKa values in protein unfolded states are close to the amino acid model pKa values, thus reflecting the weak intramolecular interactions present in the unfolded ensemble of most proteins. We have carried out thermal denaturation measurements on the WT and eight mutants of HEWL from pH 1.5 to pH 11.0 to examine the unfolded state pKa values and the pH dependence of protein stability for this enzyme. The availability of accurate pKa values for the folded state of HEWL and separa...

The Alleret Maar lacustrine sequence (French Massif Central): a 150 ka long early-middle Pleistocene continental paleoenvironmental record.

Science.gov (United States)

Nomade, S.; Pastre, J.; Guillou, H.; Gauthier, A.; Scaillet, S.

2008-12-01

Lacustrine maar sequences of the French Massif Central are of great interest for paleoclimatic and paleoenvironmental reconstructions of mid-latitudes Quaternary continental environments. In particular, the western Velay region yields exceptional sequences spanning the last 450 ka (Reille et al., J. Quat. Sci. 2000). However, older sequences remain largely unknown despite the presence of interbedded alkaline tephras allowing precise absolute radiochronological control of many lacustrine squences. The Alleret maar is a 1500 m wide phreatomagmatic crater that provides a long lacustrine sequence (41 m). The upper part of this sequence (AL2 core, 14.6 m) was studied between 2005 and 2006 (Pastre et al., C. R. Acad Sci, 2007). A 39Ar/40Ar date (557 ± 5ka) obtained from an interbedded tephra layer located at 7m as well as the associated pollen data attribute the beginning of this sequence to the MIS 15. Thanks to the AL3 core recovered in 2005 (40.6 m, CNRS Meudon) several new tephra layers were discovered in the bottom part of this lacustrine sequence. Three new 39Ar/40Ar ages (single crystal analyses) from trachytic tephra layers were obtained at the LSCE Argon Laboratory (France). These layers are located at -30.2, -36.2 and -39.2m. Ages obtained relative to the ACR-2 flux standard (1,201Ma, Kuiper et al., Science, 2008) range from 692 ± 6 ka (MSWD: 2.3, n=18) for the youngest (-30.2m) to 726 ± 9Ka Ka (MSWD: 2.2, n=12) for the lowest tephra located at -39.2m. These new dates indicate a relatively homogeneous deposition rate of 3.5cm/ka and that the last 10 meters cover the MIS 17-MIS18 period. According to these current radiochronological data the complete lacustrine sequence last more than 150ka. Ongoing sedimentary and pollen studies will allow to extend the paleoenvironmental and paleoclimatic records of the French Massif Central towards the beginning of the early middle Pleistocene.

Potential for Paragliding Tourism Development in Niška Banja (South Serbia

Directory of Open Access Journals (Sweden)

Lazar Pavić

2013-07-01

Full Text Available People today pay attention more on their health and because of that sports tourism becomes more popular. Especially popular segment of sports tourism is adventure sports including paragliding which has a special place. Tourist product of Niška Banja, as one of more visited tourism destination in Serbia, is mostly based on its health function. In the first part of this paper it is presented touristic valorisation of Niška Banja using criteria recommended form World Tourism Organization. In the second part of this paper it is used marketing mix as a tool for creating potential tourism product Paragliding weekend in Niška Banja. The aim of this paper is to show how the tourism offers of Niška Banja can be diversified using a new integrated product and how the touristic value can be increased.

Palaeocirculation across New Zealand during the last glacial maximum at ˜21 ka

Science.gov (United States)

Lorrey, Andrew M.; Vandergoes, Marcus; Almond, Peter; Renwick, James; Stephens, Tom; Bostock, Helen; Mackintosh, Andrew; Newnham, Rewi; Williams, Paul W.; Ackerley, Duncan; Neil, Helen; Fowler, Anthony M.

2012-03-01

What circulation pattern drove Southern Alps glacial advances at ˜21 ka? Late 20th century glacial advances in New Zealand are commonly attributed to a dual precipitation increase and cooler than normal temperatures associated with enhanced westerly flow that occur under synoptic pressure patterns termed 'zonal' regimes (Kidson, 2000). But was the circulation pattern that supported major Southern Alps glacial advances during the global LGM similar to the modern analog? Here, a Regional Climate Regime Classification (RCRC) time slice was used to infer past circulation for New Zealand during the LGM at ˜21 ka. Palaeoclimate information that supported the construction of the ˜21 ka time slice was derived from the NZ-INTIMATE Climate Event Stratigraphy (CES), one new Auckland maar proxy record, and additional low-resolution data sourced from the literature. The terrestrial evidence at ˜21 ka implicates several possibilities for past circulation, depending on how interpretations for some proxies are made. The interpretation considered most tenable for the LGM, based on the agreement between terrestrial evidence, marine reconstructions and palaeoclimate model results is an 'anticyclonic/zonal' circulation regime characterized by increased influences from blocking 'highs' over the South Island during winter and an increase in zonal and trough synoptic types (with southerly to westerly quarter wind flow) during summer. These seasonal circulation traits would have generated lower mean annual temperatures, cooler than normal summer temperatures, and overall lower mean annual precipitation for New Zealand (particularly in the western South Island) at ˜21 ka. The anticyclonic/zonal time slice reconstruction presented in this study has different spatial traits than the late 20th Century and the early Little Ice Age signatures, suggesting more than one type of regional circulation pattern can drive Southern Alps glacial activity. This finding lends support to the hypothesis

Advances in Ka-Band Communication System for CubeSats and SmallSats

Science.gov (United States)

Kegege, Obadiah; Wong, Yen F.; Altunc, Serhat

2016-01-01

A study was performed that evaluated the feasibility of Ka-band communication system to provide CubeSat/SmallSat high rate science data downlink with ground antennas ranging from the small portable 1.2m/2.4m to apertures 5.4M, 7.3M, 11M, and 18M, for Low Earth Orbit (LEO) to Lunar CubeSat missions. This study included link analysis to determine the data rate requirement, based on the current TRL of Ka-band flight hardware and ground support infrastructure. Recent advances in Ka-band transceivers and antennas, options of portable ground stations, and various coverage distances were included in the analysis. The link/coverage analysis results show that Cubesat/Smallsat missions communication requirements including frequencies and data rates can be met by utilizing Near Earth Network (NEN) Ka-band support with 2 W and high gain (>6 dBi) antennas.

Development of a thermally switched superconducting rectifier for 100 kA

NARCIS (Netherlands)

Mulder, G.B.J.; Mulder, G.B.J.; ten Kate, Herman H.J.; Krooshoop, Hendrikus J.G.; van de Klundert, L.J.M.; van de Klundert, L.J.M.

1991-01-01

A full-wave superconducting rectifier for 100 kA has been developed. Typical design values of this device are: a secondary current of 100 kA, a primary amplitude of 20 A, an operating frequency of 0.5 Hz, and an average power on the order of 100 W. The rectification is achieved by means of thermally

Effect of methylation on the side-chain pKa value of arginine.

Science.gov (United States)

Evich, Marina; Stroeva, Ekaterina; Zheng, Yujun George; Germann, Markus W

2016-02-01

Arginine methylation is important in biological systems. Recent studies link the deregulation of protein arginine methyltransferases with certain cancers. To assess the impact of methylation on interaction with other biomolecules, the pKa values of methylated arginine variants were determined using NMR data. The pKa values of monomethylated, symmetrically dimethylated, and asymmetrically dimethylated arginine are similar to the unmodified arginine (14.2 ± 0.4). Although the pKa value has not been significantly affected by methylation, consequences of methylation include changes in charge distribution and steric effects, suggesting alternative mechanisms for recognition. © 2015 The Protein Society.

Improving Cry8Ka toxin activity towards the cotton boll weevil (Anthonomus grandis).

Science.gov (United States)

Oliveira, Gustavo R; Silva, Maria C M; Lucena, Wagner A; Nakasu, Erich Y T; Firmino, Alexandre A P; Beneventi, Magda A; Souza, Djair S L; Gomes, José E; de Souza, José D A; Rigden, Daniel J; Ramos, Hudson B; Soccol, Carlos R; Grossi-de-Sa, Maria F

2011-09-09

The cotton boll weevil (Anthonomus grandis) is a serious insect-pest in the Americas, particularly in Brazil. The use of chemical or biological insect control is not effective against the cotton boll weevil because of its endophytic life style. Therefore, the use of biotechnological tools to produce insect-resistant transgenic plants represents an important strategy to reduce the damage to cotton plants caused by the boll weevil. The present study focuses on the identification of novel molecules that show improved toxicity against the cotton boll weevil. In vitro directed molecular evolution through DNA shuffling and phage display screening was applied to enhance the insecticidal activity of variants of the Cry8Ka1 protein of Bacillus thuringiensis. Bioassays carried out with A. grandis larvae revealed that the LC50 of the screened mutant Cry8Ka5 toxin was 3.15-fold higher than the wild-type Cry8Ka1 toxin. Homology modelling of Cry8Ka1 and the Cry8Ka5 mutant suggested that both proteins retained the typical three-domain Cry family structure. The mutated residues were located mostly in loops and appeared unlikely to interfere with molecular stability. The improved toxicity of the Cry8Ka5 mutant obtained in this study will allow the generation of a transgenic cotton event with improved potential to control A. grandis.

Improving Cry8Ka toxin activity towards the cotton boll weevil (Anthonomus grandis

Directory of Open Access Journals (Sweden)

Gomes José E

2011-09-01

Full Text Available Abstract Background The cotton boll weevil (Anthonomus grandis is a serious insect-pest in the Americas, particularly in Brazil. The use of chemical or biological insect control is not effective against the cotton boll weevil because of its endophytic life style. Therefore, the use of biotechnological tools to produce insect-resistant transgenic plants represents an important strategy to reduce the damage to cotton plants caused by the boll weevil. The present study focuses on the identification of novel molecules that show improved toxicity against the cotton boll weevil. In vitro directed molecular evolution through DNA shuffling and phage display screening was applied to enhance the insecticidal activity of variants of the Cry8Ka1 protein of Bacillus thuringiensis. Results Bioassays carried out with A. grandis larvae revealed that the LC50 of the screened mutant Cry8Ka5 toxin was 3.15-fold higher than the wild-type Cry8Ka1 toxin. Homology modelling of Cry8Ka1 and the Cry8Ka5 mutant suggested that both proteins retained the typical three-domain Cry family structure. The mutated residues were located mostly in loops and appeared unlikely to interfere with molecular stability. Conclusions The improved toxicity of the Cry8Ka5 mutant obtained in this study will allow the generation of a transgenic cotton event with improved potential to control A. grandis.

Validation of SARAL/AltiKa data in the Amazon basin

Science.gov (United States)

Santos da Silva, Joecila; Calmant, Stephane; Medeiros Moreira, Daniel; Oliveira, Robson; Conchy, Taina; Gennero, Marie-Claude; Seyler, Frederique

2015-04-01

SARAL/AltiKa is a link between past missions (since it flies on the ERS-ENVISAT orbit with Ku band nadir altimeters in LRM) and future missions such as SWOT's Ka band interferometry swaths. In the present study, we compare the capability of its altimeter AltiKa to that of previous missions working in the Ku band such as ENVISAT and Jason-2 in retrieving water levels over the Amazon basin. Same as for the aforementioned preceding missions, the best results were obtained with the ICE-1 retracking algorithm. We qualitatively analyze the impact of rainfalls in the loss of measurements. Since making long -multi mission- time series is of major importance either for hydro-climatic studies or for basin management, we also present an estimate of the altimeter bias in order that the SARAL series of water level can be appended to those of these previous missions.

Risk Assessment of Mineral Groundwater Near Rogaška Slatina

Science.gov (United States)

Trcek, Branka; Leis, Albrecht

2017-10-01

Groundwater resources of mineral and thermo-mineral water are invaluable for planning a sustainable spatial and economic development of the Rogaška Slatina area, which requires a protection of this natural heritage. Numerous previous investigations of Rogaška groundwaters were subjects to balneology and to demands for larger exploitation quantities, that is why information are missing that are essential for definition of the Rogaška fractured aquifer system with mineral and thermo-mineral water and for its protection. The isotopic investigations of groundwaters stored in the Rogaška Slatina fractured aquifer system were performed aiming at answering open questions on the groundwater recharge and dynamics, on connections between different types of aquifers and on solute transport. Environmental isotopes 2H, 18O, 3H, 13C of dissolved inorganic carbon and 14C were analysed in mineral, thermo-mineral and spring waters. Results indicated the source and mechanism of groundwater recharge, its renewability, a transit time distribution, hydraulic interrelationships, the groundwater origin and its evolution due to effects of water-rock interaction. The mean residence time estimates of mineral and thermo- mineral water in the aquifer are between 3400 and 14000 years. On the other hand, the mixing processes between younger and older waters or mineral and spring waters are reflected as well as waters that infiltrated predominantly after the 1960s. These suggest the vulnerability of the research systems to man-made impacts. The presented results coupled with available information on a physical hydrogeology and water chemistry asses the optimal balance between the environmental protection and economic use of mineral water resources in the study area. They are essential for the protection strategy development of mineral and thermo-mineral water in the Rogaška Slatina area bringing together the state administration and local authorities and stakeholders.

Substituent effect on the oxidation peak potentials of phenol derivatives at ordered mesoporous carbons modified electrode and its application in determination of acidity coefficients (pKa)

International Nuclear Information System (INIS)

Zhang, Tingting; Lang, Qiaolin; Zeng, Lingxing; Li, Tie; Wei, Mingdeng; Liu, Aihua

2014-01-01

In this paper, the relationship between the electrochemical characteristics and the structure of a series of substituted phenol derivatives with electron-donating or electron-withdrawing groups were studied by voltammetry using ordered mesoporous carbons (OMCs) modified glassy carbon electrode (GCE) (OMCs/GCE). p-Nitrophenol (p-NP) and p-methylphenol were selected as models of electron-withdrawing and electron-donating groups, respectively, to illustrate the electrochemical behavior and reaction mechanism of substituted phenols. Voltammetric study showed that the oxidation peak potential (E pa ) of substituted phenols with an electron-withdrawing group was systematically higher than that of substituted phenols with an electron-donating group. That is, the direct electrochemical oxidation of substituted phenol with an electron-withdrawing group is more difficult than that of substituted phenol with an electron-donating group. The E pa value shifted negatively with the increase of pKa for both p-substituted phenols and o-substituted phenols with the equations of pKa = −6.986 E pa + 13.261 (for p-substituted phenols) and pKa = −7.929 E pa + 13.831 (for o-substituted phenols). Thus, a simple and novel method was proposed for the precise prediction of the pKa of substituted phenols by determining E pa values with voltammetry at OMCs/GCE, which matched fairly with the results calculated from Hammett's constants. Thus, the present work may provide additional strategy to determine pKa values and investigate possible mechanisms of some organic reactions. In addition, by making use of the substituent effect, different p-substituted phenols (or o-substituted phenols) can be well separated and identified at OMCs/GCE by voltametry, which may find possible applications in simultaneous detection of p-substituted phenols (or o-substituted phenols)

Diatom species composition in the Raška river (Southwestern Serbia

Directory of Open Access Journals (Sweden)

Vidaković Danijela P.

2015-01-01

Full Text Available The paper presents data on the composition of epilithic diatoms in the Raška River. Samples were collected by scraping stone surfaces with a brush from 5 localities along the Raška River in April, June, August and November 2011 and March and May 2012. Diatom frustules were cleaned using cold acid method, and mounted on permanent slides. An investigation of the Raška River resulted in description of 106 diatom taxa. The most species rich genera are Navicula (10, Gomphonema (10 and Nitzschia (9, while other genera are presented with one or more species. Detailed floristic analysis of the benthic diatom flora in this river has not been conducted before. Therefore, this paper provides a groundwork for future researches. [Projekat Ministarstva nauke Republike Srbije, br. TR 037009

Ostaci srednjevjekovne utvrde Kaštel (Fenarlik u kartografskim izvorima XIX i XX vijeka : The remains of the fortress Kaštel (Fenarlik in cartographic sources of the 19th and 20th centuries

Directory of Open Access Journals (Sweden)

Jusuf Topoljak

2015-12-01

Full Text Available Utvrda Kaštel (Fenarlik, locirana između Novog Travnika i Bugojna, vjerovatno je podignuta u razdoblju srednjeg vijeka, a u kartografskim izvorima se prvi put javlja tek 1883. godine. Geodetski planovi i karte 19. i 20. vijeka vjerodostojno dokumentuju propadanje ostataka tog utvrđenja, isprva ga jasno prikazujući kao ruševinu, dok se naposljetku sačuvao samo toponim Kaštel. Ovim radom autori su pokušali identifikovati i objediniti sve relevantne kartografske izvore na kojima je predočen lokalitet Kaštela, uz analizu načina topografisanja ostataka srednjevjekovne utvrde. : The fortress Kaštel (Fenarlik, located between Novi Travnik and Bugojno, probably was built in the period of middle ages. Concerning cartographic sources, it first appeared in 1883. Geodetic plans and maps from the 19th and 20th century credibly documented deterioration of the fortress remains. At first, it clearly displayed a ruin, while ultimately toponym Kaštel was the only preserved. Authors of this paper tried to identify and consolidate all relevant cartographic sources that represent the place Kaštel, together with the analysis of topographing the medieval fortresses.

A 150-ka-long record for the volcano-tectonic deformation of Central Anatolian Volcanic Province

Science.gov (United States)

Karabacak, Volkan; Tonguç Uysal, I.; Ünal-İmer, Ezgi; Mutlu, Halim; Zhao, Jian-xin

2017-04-01

The Anatolian Block represents one of the most outstanding examples of intra-plate deformation related to continental collision. Deformation related to the convergence of the Afro-Arabian continent toward north gives rise to widespread and intense arc volcanism in the Central Anatolia. All the usual studies on dating the volcano-tectonic deformation of the region are performed entirely on volcanic events of the geological record resulted in eruptions. However, without volcanic eruption, magma migration and related fluid pressurization also generate crustal deformation. In the current study has been funded by the Scientific and Technological Research Council of Turkey with the project no. 115Y497, we focused on fracture systems and their carbonate veins around the Ihlara Valley (Cappadocia) surrounded by well-known volcanic centers with latest activities of the southern Central Anatolian Volcanic Province. We dated 37 samples using the Uranium-series technique and analyzed their isotope systematics from fissure veins, which are thought to be controlled by the young volcanism in the region. Our detailed fracture analyses in the field show that there is a regional dilatation as a result of a NW-SE striking extension which is consistent with the results of recent GPS studies. The Uranium-series results indicate that fracture development and associated carbonate vein deposition occurred in the last 150 ka. Carbon and oxygen isotope systematics have almost remained unchanged in the studied time interval. Although veins in the region were precipitated from fluids primarily of meteoric origin, fluids originating from water-rock interaction also contribute for the deposition of carbonate veins. The age distribution indicates that the crustal deformation intensified during 7 different period at about 4.7, 34, 44, 52, 83, 91, 149 ka BP. Four of these periods (4.7, 34, 91, 149 ka BP) correspond to the volcanic activities suggested in the previous studies. The three crustal

Simulation of weak polyelectrolytes: a comparison between the constant pH and the reaction ensemble method

Science.gov (United States)

Landsgesell, Jonas; Holm, Christian; Smiatek, Jens

2017-03-01

The reaction ensemble and the constant pH method are well-known chemical equilibrium approaches to simulate protonation and deprotonation reactions in classical molecular dynamics and Monte Carlo simulations. In this article, we demonstrate the similarity between both methods under certain conditions. We perform molecular dynamics simulations of a weak polyelectrolyte in order to compare the titration curves obtained by both approaches. Our findings reveal a good agreement between the methods when the reaction ensemble is used to sweep the reaction constant. Pronounced differences between the reaction ensemble and the constant pH method can be observed for stronger acids and bases in terms of adaptive pH values. These deviations are due to the presence of explicit protons in the reaction ensemble method which induce a screening of electrostatic interactions between the charged titrable groups of the polyelectrolyte. The outcomes of our simulation hint to a better applicability of the reaction ensemble method for systems in confined geometries and titrable groups in polyelectrolytes with different pKa values.

Reverberation Mapping of the Kepler target KA1858+48

Science.gov (United States)

Pei, Liuyi; Barth, A. J.; Malkan, M. A.; Cenko, S. B.; Clubb, K. I.; Filippenko, A. V.; Gates, E. L.; Horst, J.; Joner, M. D.; Leonard, D. C.; Sand, D. J.

2013-01-01

KA1858+48 is a Seyfert 1 galaxy at redshift 0.078 and is among the brightest active galaxies being monitored by the Kepler mission. We have carried out a reverberation mapping program designed to measure the broad-line region size and estimate the mass of the black hole in KA1858+48. We obtained spectroscopic data using the Kast Spectrograph at the Lick 3 m telescope during dark runs from late winter through fall of 2012, by requesting an observation on each night that the Kast Spectrograph was mounted on the telescope. We also obtained V-band images from the Nickel 1 m telescope at Lick Observatory, the 0.9 m telescope at Brigham Young University West Mountain Observatory, the Faulkes Telescope North at the Las Cumbres Observatory Global Telescope, the KAIT telescope at Lick Observatory, and the 1 m telescope at Mt. Laguna Observatory. The H-beta light curve shows a lag time of approximately 12 days with respect to the V-band continuum flux variations. We will present the continuum and emission-line light curves, cross-correlation lag measurements, and a preliminary estimate of the black hole mass in KA1858+48.

Muukeelne elanikkond vajab ka ETVd / Ela Tomson

Index Scriptorium Estoniae

Tomson, Ela, 1945-

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke 4. juuli lk. 7, Pjarnuskii Ekspress 7. juuli lk. 7. Autori arvates on riik jätnud Eestis elava muukeelse elanikkonna Venemaa telekanalite mõju alla. Ometi poleks see, kui varustada ETV tähtsamad saated venekeelsete subtiitritega, midagi rahamahukat ja kaelamurdvat

Acid dissociation constant and apparent nucleophilicity of lysine-501 of the alpha-polypeptide of sodium and potassium ion activated adenosinetriphosphatase

International Nuclear Information System (INIS)

Xu, K.Y.

1989-01-01

A combination of competitive labeling with [ 3 H]acetic anhydride and immunoaffinity chromatography is described that permits the assignment of the acid dissociation constant and the absolute nucleophilicity of individual lysines in a native enzyme. The acid dissociation constant of lysine-501 of the alpha-polypeptide in native (Na+ + K+)-ATPase was determined. This lysine had a normal pKa of 10.4. The rate constant for the reaction of the free base of lysine-501 with acetic anhydride at 10 degrees C is 400 M-1 s-1. This value is only 30% that for a fully accessible lysine in a protein. The lower than normal apparent nucleophilicity suggests that lysine-501 is hindered from reacting with its intrinsic nucleophilicity by the tertiary structure of the enzyme and is consistent with its location within a pocket that forms the active site upon the surface of the native protein

Insights from a synthesis of old and new climate-proxy data from the Pyramid and Winnemucca lake basins for the period 48 to 11.5 cal ka

Science.gov (United States)

Benson, Larry; Smoot, J.P.; Lund, S.P.; Mensing, S.A.; Foit, F.F.; Rye, R.O.

2013-01-01

A synthesis of old and new paleoclimatic data from the Pyramid and Winnemucca lake basins indicates that, between 48.0 and 11.5·103 calibrated years BP (hereafter ka), the climate of the western Great Basin was, to a degree, linked with the climate of the North Atlantic. Paleomagnetic secular variation (PSV) records from Pyramid Lake core PLC08-1 were tied to the GISP2 ice-core record via PSV matches to North Atlantic sediment cores whose isotopic and(or) carbonate records could be linked to the GISP2 δ18O record. Relatively dry intervals in the western Great Basin were associated with cold Heinrich events and relatively wet intervals were associated with warm Dansgaard-Oeschger (DO) oscillations. The association of western Great Basin dry events with North Atlantic cold events (and vice versa) switched sometime after the Laurentide Ice Sheet (LIS) reached its maximum extent. For example, the Lahontan highstand, which culminated at 15.5 ka, and a period of elevated lake level between 13.1 and 11.7 ka were associated with cold North Atlantic conditions, the latter period with the Youngest Dryas event. Relatively dry periods were associated with the Bølling and Allerød warm events. A large percentage of the LIS may have been lost to the North Atlantic during Heinrich events 1 and 2 and may have resulted in the repositioning of the Polar Jet Stream over North America. The Trego Hot Springs, Wono, Carson Sink, and Marble Bluff tephras found in core PLC08-1 have been assigned GISP2 calendar ages of respectively, 29.9, 33.7, 34.1, and 43.2 ka. Given its unique trace-element chemistry, the Carson Sink Bed is the same as Wilson Creek Ash 15 in the Mono Lake Basin. This implies that the Mono Lake magnetic excursion occurred at approximately 34 ka and it is not the Laschamp magnetic excursion. The entrance of the First Americans into the northern Great Basin is dated to approximately 14.4 ka, a time when the climate was relatively dry. Evidence for human occupation of

AHP 44: BILINGUAL EDUCATION IN AMDO - A CASE STUDY OF KHRI KA NATIONALITIES BOARDING SCHOOL

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Tshe dpal rdo rje ཚེ་དཔལ་རྡོ་རྗེ། (Caihuan Duojie 才还多杰

2017-02-01

Full Text Available The state sponsored education of Tibetan children in Khri ka (Guide County, Mtsho lho (Hainan Tibetan Autonomous Prefecture, Mtsho sngon (Qinghai Province, China, using Khri ka Nationalities Boarding School as a case study, is described. School history, the government rationale for closing village-based Tibetan primary schools, and the nationalities boarding schools operating in Khri ka in 2015 are introduced. Detailed descriptions of teachers; students; instructional materials; classes; language use; rules; punishments; home visiting; communication between students, parents, and teachers; school reports to the local authorities; and official local supervision and evaluation of Khri ka Nationalities Boarding School are also provided. An overall evaluation of this school concludes the paper.

Solubility behavior of narcotic analgesics in aqueous media: solubilities and dissociation constants of morphine, fentanyl, and sufentanil.

Science.gov (United States)

Roy, S D; Flynn, G L

1989-02-01

The pH dependence of the aqueous solubility of morphine, fentanyl, and sufentanil was investigated at 35 degrees C. Dissociation constants and corresponding pKa' values of the drugs were obtained from measured free-base solubilities (determined at high pH's) and the concentrations of saturated solutions at intermediate pH's. Morphine, fentanyl, and sufentanil exhibited pKa' values of 8.08, 8.99, and 8.51, respectively. Over the pH range of 5 to 12.5 the apparent solubilities are determined by the intrinsic solubility of the free base plus the concentration of ionized drug necessary to satisfy the dissociation equilibrium at a given pH. Consequently, the drug concentrations of saturated aqueous solutions fall off precipitously as the pH is raised and ionization is suppressed. Further, at low pH's the aqueous solubility of morphine increased in a linear fashion with increases in the molar strength of citric acid which was added to acidify the medium, suggesting the formation of a soluble morphine-citrate complex.

Kõik, mis valesti sai minna, see on ka valesti läinud / George Soros

Index Scriptorium Estoniae

Soros, George, 1930-

2008-01-01

Ilmunud ka: Molodjozh Estonii : Biznes Sreda, Delovõje Vedomosti 6. veebr. lk. 10. Praegune finantskriis, mille käivitas kinnisvaramulli lõhkemine USA-s, tähistab ka dollari kui rahvusvahelisel reservvaluutal baseeruva laenuandmise laienemise ajastu lõppu

Ka-band Technologies for Small Spacecraft Communications via Relays and Direct Data Downlink

Science.gov (United States)

Budinger, James M.; Niederhaus, Charles; Reinhart, Richard; Downey, Joe; Roberts, Anthony

2016-01-01

As the scientific capabilities and number of small spacecraft missions in the near Earth region increase, standard yet configurable user spacecraft terminals operating in Ka-band are needed to lower mission cost and risk and enable significantly higher data return than current UHF or S-band terminals. These compact Ka-band terminals are intended to operate with both the current and next generation of Ka-band relay satellites and via direct data communications with near Earth tracking terminals. This presentation provides an overview of emerging NASA-sponsored and commercially provided technologies in software defined radios (SDRs), transceivers, and electronically steered antennas that will enable data rates from hundreds of kbps to over 1 Gbps and operate in multiple frequency bands (such as S- and X-bands) and expand the use of NASA's common Ka-bands frequencies: 22.55-23.15 GHz for forward data or uplink; and 25.5-27.0 GHz for return data or downlink. Reductions in mass, power and volume come from integration of multiple radio functions, operations in Ka-band, high efficiency amplifiers and receivers, and compact, flat and vibration free electronically steered narrow beam antennas for up to + 60 degrees field of regard. The software defined near Earth space transceiver (SD-NEST) described in the presentation is intended to be compliant with NASA's space telecommunications radio system (STRS) standard for communications waveforms and hardware interoperability.

Ka-band waveguide rotary joint

KAUST Repository

Yevdokymov, Anatoliy

2013-04-11

The authors present a design of a waveguide rotary joint operating in Ka-band with central frequency of 33 GHz, which also acts as an antenna mount. The main unit consists of two flanges with a clearance between them; one of the flanges has three circular choke grooves. Utilisation of three choke grooves allows larger operating clearance. Two prototypes of the rotary joint have been manufactured and experimentally studied. The observed loss is from 0.4 to 0.8 dB in 1.5 GHz band.

MARIJANSKA PUČKA BLAGDANSKA IMENA NA DUBROVAČKOM PODRUČJU

OpenAIRE

Vulić, Sanja

2009-01-01

U radu se opisuju pučka imena blagdana Gospe Karmelske, Gospe od Anđela, Gospina Pohoda sv. Elizabeti, Gospe od Krunice, Gospe Snježne, Gospe od Zdravlja, Gospe Lurdske, Gospe Fatimske, Imena Marijina, Gospe od Sedam Žalosti, Bezgrješnoga Začeća, Velike Gospe, Male Gospe i nekih lokalnih svetkovina. Uglavnom se razmatraju pučka blagdanska imena koja sam prikupila osobnim terenskim istraživanjem u samom gradu Dubrovniku, u Postranju u Župi dubrovačkoj, u Trpnju i Orebiću na Pelješcu te na otok...

Aeroflot tahab ka ise Moskvast Tallinna lennata / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2011-01-01

Aeroflot kavatseb suurendada oma rahvusvaheliste reiside hulka umbes veerandi võrra, uute sihtkohtade seas on infoportaali ATO.ru andmeil ka Tallinn. Tallinna lennujaama juhatuse liikme Erik Sakkovi kommentaare

Ka-Band Electronically Steered CubeSat Antenna, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Kymeta Government Solutions (KGS) designed, analyzed, built, tested, and delivered a small, lightweight, low-cost, low-power electronically steered Ka-band prototype...

Ka-Band Klystron Amplifier for CUBESATs, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — We propose a Ka-Band klystron amplifier for use in CubeSats. It will operate at 35.7 GHz, have 400 MHz of bandwidth, and output at least 32 watts of saturated power....

pKa-critical Interpretations of Solubility–pH Profiles: PG 300995 and NSC-639829 Case Studies

Directory of Open Access Journals (Sweden)

George Butcher

2015-07-01

Full Text Available Two weak bases, PG-300995 (anti-HIV agent and NSC-639829 (anti-tumor agent, whose log S – pH profiles had been previously published, but whose pKa values had not been reported, were analyzed using a method which can determine pKa values from log S – pH data. This “SpH-pKa” technique, although often practiced, can result in inaccurate pKa values, for a variety of reasons. The operational SpH-pKa values were compared to those predicted by MarvinSketch (ChemAxon, ADMET Predictor (Simulation Plus, and ACD/Percepta (ACD/Labs. The agreement for the sparingly-soluble PG-300995 was reasonably good. However, a substantial difference was found for the practically-insoluble NSC-639829. To probe this further, the pKa of NSC‑639829 was measured by an independent spectrophotometric cosolvent technique. The log S - pH profile of NSC-639829 was then re‑analyzed with the independently-measured pKa. It was found that the equilibrium model which best fit the solubility data is consistent with the presence of a monocationic NSC-639829 dimeric species below pH 4. This illustrates that an independently-determined accurate pKa is critical to mechanistic interpretations of solubility-pH data. Apparently, the Henderson-Hasselbalch equation holds for PG-300995, but not NSC-639829.

Networking of Fruška Gora Lakes Tourist Offer through System of Cyclepaths – Case Study Sot, Bruje and Moharač (Serbia

Directory of Open Access Journals (Sweden)

Aleksandra Vujko

2011-01-01

Full Text Available Fruška gora lakes Sot, Bruje and Moharač are the lakes that can be used in many ways for sports and recreation tourism. Nevertheless, the current tourism offer in these lakes is based only on offer for sports fishing. Bearing in mind that Fruška gora National Park, where there are three zones of protection, is of great importance the fact that the second and third zones are, with regard to territorial perspective, areas where it is desirable to develop sports and recreational tourism. Cycling is becoming an increasingly popular form of sports and recreational tourism, so tourism networking of Fruška gora lakes with system of cycle paths would represent only the first step to turn the whole mountain into the European cycle mainstream. In this sense, the aim of this paper is set to map the FJSA cycling paths connected to the system. The field research resulted in the mapping of the terrain. The interviews with experts from the Provincial Secretariat of Environmental Protection, the National Park and the Cycling Association of Vojvodina helped in the SWOT analysis of cycle tourism on Fruška gora lakes.

Descriptional Complexity of the Languages KaL: Automata, Monoids and Varieties

Directory of Open Access Journals (Sweden)

Ondřej Klíma

2010-08-01

Full Text Available The first step when forming the polynomial hierarchies of languages is to consider languages of the form KaL where K and L are over a finite alphabet A and from a given variety V of languages, a being a letter from A. All such KaL's generate the variety of languages BPol1(V. We estimate the numerical parameters of the language KaL in terms of their values for K and L. These parameters include the state complexity of the minimal complete DFA and the size of the syntactic monoids. We also estimate the cardinality of the image of A* in the Schuetzenberger product of the syntactic monoids of K and L. In these three cases we obtain the optimal bounds. Finally, we also consider estimates for the cardinalities of free monoids in the variety of monoids corresponding to BPol1(V in terms of sizes of the free monoids in the variety of monoids corresponding to V.

NOAA Ship Ka'imimoana Underway Meteorological Data, Quality Controlled

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Ship Ka'imimoana Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and Oceanographic System...

Revalidation and rationale for high pKa values of unconjugated bilirubin

Directory of Open Access Journals (Sweden)

Ostrow J Donald

2007-05-01

Full Text Available Abstract Background Our prior solvent partition analysis, published in 1992, yielded pKa values for unconjugated bilirubin of about 8.1 and 8.4, but these results have been challenged and studies by other methods have suggested pKa values below 5.0. Methods We repeated our published solvent partition studies, using 14C-unconjugated bilirubin highly purified by extraction of residual labeled impurities from CHCl3 into an aqueous buffer, pH 7.0. Partition ratios at six pH values from 5.0 to 9.0 were determined by radioassay and compared with our prior values obtained by diazo assay. Results At pH values ranging from 4.8 to 9.2, stable aqueous/chloroform 14C-partition ratios did not differ significantly from our published partition ratios based on diazo assay. Conclusion These results support the high pKa values of unconjugated bilirubin, above 8.0, derived from our earlier solvent partition study. In both studies, our measurements were based on the rapid analysis of clearly under-saturated solutions of highly-purified bilirubin over a wide pH range, using properly purified and preserved solvents. No previous direct estimate of the aqueous pKa values of unconjugated bilirubin meets all these preconditions. Three theoretical factors acting in combination, each related to the unique, extensive internal H-bonding of the -COOH groups, are proposed to support high pKa values of unconjugated bilirubin in water: a donation of an H-bond from the -OH moiety of the -COOH group, which is broken on ionization; b hindered solvation of the -COO- group after ionization; and c restricted rotation of the -COO- and -COOH groups. Our findings and rationale rebut methodological and theoretical criticisms leveled against our prior work. High pKa values for unconjugated bilirubin dictate that: a bilirubin diacid, which readily diffuses across membranes and can cause neurotoxicity, is the dominant unbound bilirubin species of unconjugated bilirubin in plasma at

pKa prediction for acidic phosphorus-containing compounds using multiple linear regression with computational descriptors.

Science.gov (United States)

Yu, Donghai; Du, Ruobing; Xiao, Ji-Chang

2016-07-05

Ninety-six acidic phosphorus-containing molecules with pKa 1.88 to 6.26 were collected and divided into training and test sets by random sampling. Structural parameters were obtained by density functional theory calculation of the molecules. The relationship between the experimental pKa values and structural parameters was obtained by multiple linear regression fitting for the training set, and tested with the test set; the R(2) values were 0.974 and 0.966 for the training and test sets, respectively. This regression equation, which quantitatively describes the influence of structural parameters on pKa , and can be used to predict pKa values of similar structures, is significant for the design of new acidic phosphorus-containing extractants. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

GPM, DPR Level 2A Ka Precipitation V03

Data.gov (United States)

National Aeronautics and Space Administration — The 2AKa algorithm provides precipitation estimates from the Ka radar of the Dual-Frequency Precipitation Radar on the core GPM spacecraft. The product contains two...

Elongational flow of polymer melts at constant strain rate, constant stress and constant force

Science.gov (United States)

Wagner, Manfred H.; Rolón-Garrido, Víctor H.

2013-04-01

Characterization of polymer melts in elongational flow is typically performed at constant elongational rate or rarely at constant tensile stress conditions. One of the disadvantages of these deformation modes is that they are hampered by the onset of "necking" instabilities according to the Considère criterion. Experiments at constant tensile force have been performed even more rarely, in spite of the fact that this deformation mode is free from necking instabilities and is of considerable industrial relevance as it is the correct analogue of steady fiber spinning. It is the objective of the present contribution to present for the first time a full experimental characterization of a long-chain branched polyethylene melt in elongational flow. Experiments were performed at constant elongation rate, constant tensile stress and constant tensile force by use of a Sentmanat Extensional Rheometer (SER) in combination with an Anton Paar MCR301 rotational rheometer. The accessible experimental window and experimental limitations are discussed. The experimental data are modelled by using the Wagner I model. Predictions of the steady-start elongational viscosity in constant strain rate and creep experiments are found to be identical, albeit only by extrapolation of the experimental data to Hencky strains of the order of 6. For constant stress experiments, a minimum in the strain rate and a corresponding maximum in the elongational viscosity is found at a Hencky strain of the order of 3, which, although larger than the steady-state value, follows roughly the general trend of the steady-state elongational viscosity. The constitutive analysis also reveals that constant tensile force experiments indicate a larger strain hardening potential than seen in constant elongation rate or constant tensile stress experiments. This may be indicative of the effect of necking under constant elongation rate or constant tensile stress conditions according to the Considère criterion.

Connecting Fundamental Constants

International Nuclear Information System (INIS)

Di Mario, D.

2008-01-01

A model for a black hole electron is built from three basic constants only: h, c and G. The result is a description of the electron with its mass and charge. The nature of this black hole seems to fit the properties of the Planck particle and new relationships among basic constants are possible. The time dilation factor in a black hole associated with a variable gravitational field would appear to us as a charge; on the other hand the Planck time is acting as a time gap drastically limiting what we are able to measure and its dimension will appear in some quantities. This is why the Planck time is numerically very close to the gravitational/electric force ratio in an electron: its difference, disregarding a π√(2) factor, is only 0.2%. This is not a coincidence, it is always the same particle and the small difference is between a rotating and a non-rotating particle. The determination of its rotational speed yields accurate numbers for many quantities, including the fine structure constant and the electron magnetic moment

Tautomers and Acid Dissociation Constants of 6-Selenoguanine from Density Functional Theoretical Calculations

International Nuclear Information System (INIS)

Kim, Yong Seong; Jang, Yun Hee; Cho, Hyun; Hwang, Sun Gu

2010-01-01

The relative stabilities of the tautomers of SeG were calculated. In the aqueous phase, amino-seleno form was the major tautomer of neutral SeG with a minor contribution from the other amino-seleno form. The presence of the selenolic form was negligible from the calculations. The microscopic and macroscopic pKa values in the aqueous phase were calculated from this scheme. The calculated pKa value was in good agreement with the experimental data. These results demonstrated that this method could predict and explain the acid-base properties of SeG and could be used to understand the behavior of the species. A number of analogues of nucleic acid bases have been the target of extensive studies because of their importance in many biological studies. The oxygen of both purine and pyrimidine bases is substituted with sulfur or selenium to produce an important class of analogues. 6-Selenoguanine (SeG) has a significant activity against L5178Y lymphoma cells. However, the detailed mechanism of the antiplastic action is not known yet. Information on the acid dissociation constants and the tautomerism of the molecules is required to provide a molecular level understanding of biological processes. Proton-transfer in the nucleic acid pairs and the presence of the tautomeric equilibrium play an important role in the mispair formation during the DNA replication

Under tõi kirjanduse juurde ka Ilvese / Jaanus Kulli

Index Scriptorium Estoniae

Kulli, Jaanus, 1955-

2009-01-01

Sirje Kiini raamatust "Marie Under : elu, luuletaja identiteet ja teoste vastuvõtt" (Tallinn : Tänapäev, 2009), mille esitlus toimus 10. dets. Kirjanike Majas Tallinnas. Sõnavõtuga esines ka president Toomas Hendrik Ilves

Swedbank hüvitab tekitatud kahju ka fondi vahetajatele

Index Scriptorium Estoniae

2009-01-01

Swedbank hüvitab veel enne 2009. aasta lõppu Private Debt Fondi osaku puhasväärtuse alanemise kolmandas kvartalis ning kompensatsiooni saavad ka need kliendid, kes on andnud sisse pensionifondi vahetamise taotluse

Internetiside VoIP sobib ka ettevõtteile / Valdur Laid

Index Scriptorium Estoniae

Laid, Valdur, 1969-

2005-01-01

Ilmunud ka: Delovõje Vedomosti 8. juuni lk. 19. Kommunikatsiooni liikumisest internetti ehk IP-võrku ning selle võimalustest ettevõtjaile. Vt. samas: Väikefirmade IP-lahendus jõuab aasta lõpus massturule

Molecular Paleoclimate Reconstructions over the Last 9 ka from a Peat Sequence in South China

Science.gov (United States)

Wang, Xinxin; Huang, Xianyu; Sachse, Dirk; Ding, Weihua; Xue, Jiantao

2016-01-01

To achieve a better understanding of Holocene climate change in the monsoon regions of China, we investigated the molecular distributions and carbon and hydrogen isotope compositions (δ13C and δD values) of long-chain n-alkanes in a peat core from the Shiwangutian (SWGT) peatland, south China over the last 9 ka. By comparisons with other climate records, we found that the δ13C values of the long-chain n-alkanes can be a proxy for humidity, while the δD values of the long-chain n-alkanes primarily recorded the moisture source δD signal during 9–1.8 ka BP and responded to the dry climate during 1.8–0.3 ka BP. Together with the average chain length (ACL) and the carbon preference index (CPI) data, the climate evolution over last 9 ka in the SWGT peatland can be divided into three stages. During the first stage (9–5 ka BP), the δ13C values were depleted and CPI and Paq values were low, while ACL values were high. They reveal a period of warm and wet climate, which is regarded as the Holocene optimum. The second stage (5–1.8 ka BP) witnessed a shift to relatively cool and dry climate, as indicated by the more positive δ13C values and lower ACL values. During the third stage (1.8–0.3 ka BP), the δ13C, δD, CPI and Paq values showed marked increase and ACL values varied greatly, implying an abrupt change to cold and dry conditions. This climate pattern corresponds to the broad decline in Asian monsoon intensity through the latter part of the Holocene. Our results do not support a later Holocene optimum in south China as suggested by previous studies. PMID:27505008

Molecular Paleoclimate Reconstructions over the Last 9 ka from a Peat Sequence in South China.

Directory of Open Access Journals (Sweden)

Xinxin Wang

Full Text Available To achieve a better understanding of Holocene climate change in the monsoon regions of China, we investigated the molecular distributions and carbon and hydrogen isotope compositions (δ13C and δD values of long-chain n-alkanes in a peat core from the Shiwangutian (SWGT peatland, south China over the last 9 ka. By comparisons with other climate records, we found that the δ13C values of the long-chain n-alkanes can be a proxy for humidity, while the δD values of the long-chain n-alkanes primarily recorded the moisture source δD signal during 9-1.8 ka BP and responded to the dry climate during 1.8-0.3 ka BP. Together with the average chain length (ACL and the carbon preference index (CPI data, the climate evolution over last 9 ka in the SWGT peatland can be divided into three stages. During the first stage (9-5 ka BP, the δ13C values were depleted and CPI and Paq values were low, while ACL values were high. They reveal a period of warm and wet climate, which is regarded as the Holocene optimum. The second stage (5-1.8 ka BP witnessed a shift to relatively cool and dry climate, as indicated by the more positive δ13C values and lower ACL values. During the third stage (1.8-0.3 ka BP, the δ13C, δD, CPI and Paq values showed marked increase and ACL values varied greatly, implying an abrupt change to cold and dry conditions. This climate pattern corresponds to the broad decline in Asian monsoon intensity through the latter part of the Holocene. Our results do not support a later Holocene optimum in south China as suggested by previous studies.

18 Ka BP records of climatic changes, Bay of Bengal: Isotopic and sedimentological evidences

Digital Repository Service at National Institute of Oceanography (India)

Chauhan, O.S.; Suneethi, J.

are also identified at 10.3 and 11.5 Ka BP. The later event matches well with that of the ‘Younger Dryas’ event of world climate models. The beginning of the Holocene is marked by lighter d18O values (at around 9.5 Ka BP), which has been interpreted...

Comparison of AltiKa and CryoSat-2 Elevation and Elevation Rates over the Amundsen Sea Sector

Science.gov (United States)

Otosaka, I.; Shepherd, A.; Hogg, A.

2017-12-01

Altimeters have been successfully used for more than two decades to observe changes in the ice sheet surface and to estimate the contribution of ice sheets to sea level rise. The Satellite for Argos and AltiKa (SARAL) was launched in February 2013 as a joint mission between the French space agency (CNES) and the Indian Space Research Organisation (ISRO). While the altimeters previously launched into space are operating at Ku-band (13.6 GHz), the altimeter on board SARAL, AltiKa, is the first instrument to operate at Ka-band (36.8 GHz). The higher frequency of AltiKa is expected to lead to reduced penetration of the radar signal into the snowpack, compared to Ku-band. A comparison of ice sheet elevation measurements recorded at the two frequencies may therefore provide useful information on surface and its scattering properties. In this study, we compare elevation and elevation rates recorded by AltiKa and CryoSat-2 between March 2013 and April 2017 over the Amundsen Sea Sector (ASS), one of the most rapidly changing sectors of West Antarctica. Elevation and elevation rates are computed within 5 km grid cells using a plane fit method, taking into account the contributions of topography and fluctuations in elevation and backscatter. The drifting orbit and imaging modes of CryoSat-2 result in 78,7 % sampling of the study area, whereas AltiKa samples 39,7 % due to its sparser orbit pattern and due to loss of signal in steeply sloping coastal margins. Over the study period, the root mean square difference between elevation and elevation change recorded at Ka-band and Ku-band were 40.3 m and 0.54 m/yr, respectively. While the broad spatial pattern of elevation change is well resolved by both satellites, data gaps along the Getz coastline may be partly responsible for the lower elevation change rate observed at Ka-band. We also compared CryoSat-2 and AltiKa to coincident airborne data from NASA's Operation IceBridge (OIB). The mean difference of elevation rate between

Zero cosmological constant from normalized general relativity

International Nuclear Information System (INIS)

Davidson, Aharon; Rubin, Shimon

2009-01-01

Normalizing the Einstein-Hilbert action by the volume functional makes the theory invariant under constant shifts in the Lagrangian. The associated field equations then resemble unimodular gravity whose otherwise arbitrary cosmological constant is now determined as a Machian universal average. We prove that an empty space-time is necessarily Ricci tensor flat, and demonstrate the vanishing of the cosmological constant within the scalar field paradigm. The cosmological analysis, carried out at the mini-superspace level, reveals a vanishing cosmological constant for a universe which cannot be closed as long as gravity is attractive. Finally, we give an example of a normalized theory of gravity which does give rise to a non-zero cosmological constant.

Determination of complex association constants from gas chromatograhic data

NARCIS (Netherlands)

Ligny, C.L. de; Koole, N.J.; Nelson, H.D.; Nieuwdorp, G.H.E.

1975-01-01

Abstract The equilibrium constants for hydrogen bonding of a series of β-substituted alcohols with a number of monofunctional hexadecyl derivatives and dioctyl compounds have been measured by gas chromatography. For ethanol, propanol and butanol, the enthalpy and standard entropy of hydrogen

Ehitusala tõus jätkus ka mullu

Index Scriptorium Estoniae

2004-01-01

Ilmunud ka: Delovõje Vedomosti, 3. nov. 2004, lk. 14-15. Ehitusfirmade TOP 95 aastal 2003. Kasumi TOP 40. Käibe TOP 40. TOP-i koostamise metoodika. Kasumi kasvu TOP 20. Käibe kasvu TOP 20. Omakapitali tootluse TOP 20. Rentaabluse TOP 20. Ehitusettevõtete üld- ja finantsandmed

The IUPAC aqueous and non-aqueous experimental pKa data repositories of organic acids and bases.

Science.gov (United States)

Slater, Anthony Michael

2014-10-01

Accurate and well-curated experimental pKa data of organic acids and bases in both aqueous and non-aqueous media are invaluable in many areas of chemical research, including pharmaceutical, agrochemical, specialty chemical and property prediction research. In pharmaceutical research, pKa data are relevant in ligand design, protein binding, absorption, distribution, metabolism, elimination as well as solubility and dissolution rate. The pKa data compilations of the International Union of Pure and Applied Chemistry, originally in book form, have been carefully converted into computer-readable form, with value being added in the process, in the form of ionisation assignments and tautomer enumeration. These compilations offer a broad range of chemistry in both aqueous and non-aqueous media and the experimental conditions and original reference for all pKa determinations are supplied. The statistics for these compilations are presented and the utility of the computer-readable form of these compilations is examined in comparison to other pKa compilations. Finally, information is provided about how to access these databases.

High Current, Low Voltage Power Converter [20kA, 6V] LHC Converter Prototype

CERN Document Server

Jørgensen, H E; Dupaquier, A; Fernqvist, G

1998-01-01

The superconducting LHC accelerator requires high currents (~12.5kA) and relatively low voltages (~10 V) for its magnets. The need to install the power converters underground is the driving force for reduced volume and high efficiency. Moreover, the LHC machine will require a very high level of performance from the power converters, particularly in terms of DC stability, dynamic response and also in matters of EMC. To meet these requirements soft-switching techniques will be used. This paper describes the development of a [20kA,6V] power converter intended as a stable high-current source for D CCT calibration and an evaluation prototype for the future LHC converters. The converter is made with a modular concept with five current sources [4kA,6V] in parallel. The 4kA sources are built as plu g-in modules: a diode rectifier on the AC mains with a damped L-C passive filter, a Zero Voltage Switching inverter working at 20 kHz and an output stage (high frequency transformers, Schottky rectifi ers and output filter...

Constant physics and characteristics of fundamental constant

International Nuclear Information System (INIS)

Tarrach, R.

1998-01-01

We present some evidence which supports a surprising physical interpretation of the fundamental constants. First, we relate two of them through the renormalization group. This leaves as many fundamental constants as base units. Second, we introduce and a dimensional system of units without fundamental constants. Third, and most important, we find, while interpreting the units of the a dimensional system, that is all cases accessible to experimentation the fundamental constants indicate either discretization at small values or boundedness at large values of the corresponding physical quantity. (Author) 12 refs

Test results on prototype 50-kA conductors for tokamak induction heating coils

International Nuclear Information System (INIS)

Wollan, J.J.; Williamson, K.D. Jr.; Turck, B.

1979-01-01

Fabricability of a very large, 50-kA superconducting cable has been demonstrated. Test results of critical current and stability measurements are presented. The design critical current of 55 kA at 7 T was met. The recovery current was degraded as a result of the expectedly poor insulation system. Energy loss measurements on prototype advanced mixed matrix conductors, which will be incorporated into a second prototype cable, are presented

Electrostatic contribution of surface charge residues to the stability of a thermophilic protein: benchmarking experimental and predicted pKa values.

Directory of Open Access Journals (Sweden)

Chi-Ho Chan

Full Text Available Optimization of the surface charges is a promising strategy for increasing thermostability of proteins. Electrostatic contribution of ionizable groups to the protein stability can be estimated from the differences between the pKa values in the folded and unfolded states of a protein. Using this pKa-shift approach, we experimentally measured the electrostatic contribution of all aspartate and glutamate residues to the stability of a thermophilic ribosomal protein L30e from Thermococcus celer. The pKa values in the unfolded state were found to be similar to model compound pKas. The pKa values in both the folded and unfolded states obtained at 298 and 333 K were similar, suggesting that electrostatic contribution of ionizable groups to the protein stability were insensitive to temperature changes. The experimental pKa values for the L30e protein in the folded state were used as a benchmark to test the robustness of pKa prediction by various computational methods such as H++, MCCE, MEAD, pKD, PropKa, and UHBD. Although the predicted pKa values were affected by crystal contacts that may alter the side-chain conformation of surface charged residues, most computational methods performed well, with correlation coefficients between experimental and calculated pKa values ranging from 0.49 to 0.91 (p<0.01. The changes in protein stability derived from the experimental pKa-shift approach correlate well (r = 0.81 with those obtained from stability measurements of charge-to-alanine substituted variants of the L30e protein. Our results demonstrate that the knowledge of the pKa values in the folded state provides sufficient rationale for the redesign of protein surface charges leading to improved protein stability.

Spectrofluorimetric determination of stoichiometry and association constants of the complexes of harmane and harmine with beta-cyclodextrin and chemically modified beta-cyclodextrins.

Science.gov (United States)

Martín, L; León, A; Olives, A I; Del Castillo, B; Martín, M A

2003-06-13

The association characteristics of the inclusion complexes of the beta-carboline alkaloids harmane and harmine with beta-cyclodextrin (beta-CD) and chemically modified beta-cyclodextrins such as hydroxypropyl-beta-cyclodextrin (HPbeta-CD), 2,3-di-O-methyl-beta-cyclodextrin (DMbeta-CD) and 2,3,6-tri-O-methyl-beta-cyclodextrin (TMbeta-CD) are described. The association constants vary from 112 for harmine/DMbeta-CD to 418 for harmane/HPbeta-CD. The magnitude of the interactions between the host and the guest molecules depends on the chemical and geometrical characteristics of the guest molecules and therefore the association constants vary for the different cyclodextrin complexes. The steric hindrance is higher in the case of harmine due to the presence of methoxy group on the beta-carboline ring. The association obtained for the harmane complexes is stronger than the one observed for harmine complexes except in the case of harmine/TMbeta-CD. Important differences in the association constants were observed depending on the experimental variable used in the calculations (absolute value of fluorescence intensity or the ratio between the fluorescence intensities corresponding to the neutral and cationic forms). When fluorescence intensity values were considered, the association constants were higher than when the ratio of the emission intensity for the cationic and neutral species was used. These differences are a consequence of the co-existence of acid-base equilibria in the ground and in excited states together with the complexation equilibria. The existence of a proton transfer reaction in the excited states of harmane or harmine implies the need for the experimental dialysis procedure for separation of the complexes from free harmane or harmine. Such methodology allows quantitative results for stoichiometry determinations to be obtained, which show the existence of both 1:1 and 1:2 beta-carboline alkaloid:CD complexes with different solubility properties.

The Evolution of Deepwater Dissolved Oxygen in the Northern South China Sea During the Past 400 ka

Science.gov (United States)

Wang, N.; Huang, B.; Dong, Y.

2016-12-01

Reconstruction of dissolved oxygen in paleo-ocean contributes toward understanding the history of ocean circulation, climate, causes of extinctions, and the evolution of marine organisms. Based on analysis of benthic foraminifera oxygen index (BFOI), the redox-sensitive trace elements (Mo/Al), the percentage of epifaunal benthic foraminifera and infaunal/epifaunal ratio at core MD12-3432, we reconstruct the evolution of deep water dissolved oxygen in northern South China Sea (SCS) during the past 400 ka and discuss the mechanisms of variable dissolved oxygen. Both BFOI and Mo/Al are redox indicators. Similar trends confirm that they reflect the variation of dissolved oxygen in seawater since 400 ka accurately. BFOI and Mo/Al indicate that dissolved oxygen was high in MIS 11-MIS 7 and decreased gradually during MIS 6- MIS 2. The percentage of epifauna decreased and infaunal/epifaunal ratio increased with decreasing dissolved oxygen. By comparison of dissolved oxygen and productivity indexes such as phytoplankton total (PT) and species abundances, we found that when PT fluctuated in the average range of 1000-1500 ng/g, the abundances of Bulimina and Uvigerina which represent high productivity increased. However, when PT reached the range of 2500-3000 ng/g, the abundances of Bulimina and Uvigerina didn't increase, but the abundances of dysoxic species Chilostomella oolina and Globobulimina pacifica increased and the dissolved oxygen reached low value. The reasons may be that the decomposition of excessive organic matter consumed more dissolved oxygen. The low dissolved oxygen suppressed the growth of Bulimina and Uvigerina and accelerated the boom of C. oolina and G. oolina. The dissolved oxygen is not only associated with productivity, but also affected by the thermohaline circulation. Benthic foraminifera F. favus is the representative species in Pacific deep water. Its appearance at 194 ka, 205 ka, 325, the 328 ka in MD12-3432 indicate that the upper border of

Interacting universes and the cosmological constant

International Nuclear Information System (INIS)

Alonso-Serrano, A.; Bastos, C.; Bertolami, O.; Robles-Pérez, S.

2013-01-01

In this Letter it is studied the effects that an interaction scheme among universes can have in the values of their cosmological constants. In the case of two interacting universes, the value of the cosmological constant of one of the universes becomes very close to zero at the expense of an increasing value of the cosmological constant of the partner universe. In the more general case of a chain of N interacting universes with periodic boundary conditions, the spectrum of the Hamiltonian splits into a large number of levels, each of them associated with a particular value of the cosmological constant, that can be occupied by single universes revealing a collective behavior that plainly shows that the multiverse is much more than the mere sum of its parts

Interacting universes and the cosmological constant

Energy Technology Data Exchange (ETDEWEB)

Alonso-Serrano, A. [Centro de Física “Miguel Catalán”, Instituto de Física Fundamental, Consejo Superior de Investigaciones Científicas, Serrano 121, 28006 Madrid (Spain); Estación Ecológica de Biocosmología, Pedro de Alvarado 14, 06411 Medellín (Spain); Bastos, C. [Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Avenida Rovisco Pais 1, 1049-001 Lisboa (Portugal); Bertolami, O. [Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Avenida Rovisco Pais 1, 1049-001 Lisboa (Portugal); Departamento de Física e Astronomia, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto (Portugal); Robles-Pérez, S., E-mail: salvarp@imaff.cfmac.csic.es [Centro de Física “Miguel Catalán”, Instituto de Física Fundamental, Consejo Superior de Investigaciones Científicas, Serrano 121, 28006 Madrid (Spain); Estación Ecológica de Biocosmología, Pedro de Alvarado 14, 06411 Medellín (Spain); Física Teórica, Universidad del País Vasco, Apartado 644, 48080 Bilbao (Spain)

2013-02-12

In this Letter it is studied the effects that an interaction scheme among universes can have in the values of their cosmological constants. In the case of two interacting universes, the value of the cosmological constant of one of the universes becomes very close to zero at the expense of an increasing value of the cosmological constant of the partner universe. In the more general case of a chain of N interacting universes with periodic boundary conditions, the spectrum of the Hamiltonian splits into a large number of levels, each of them associated with a particular value of the cosmological constant, that can be occupied by single universes revealing a collective behavior that plainly shows that the multiverse is much more than the mere sum of its parts.

Drastic lake level changes of Lake Van (eastern Turkey) during the past ca. 600 ka: climatic, volcanic and tectonic control

Science.gov (United States)

Cukur, D.; Krastel, S.; Schmincke, H.; Sumita, M.; Tomonaga, Y.; Damci, E.

2013-12-01

Lake Van is the largest soda lake in the world with a present surface of 3,574 km2 and a maximum water depth of 450 m. Sedimentary deposits in the lake preserve one of the most complete record of continental climate in the Middle East since the Middle Pleistocene. We studied these deposits to characterize the evolution of the lake level and its possible relationships with changes in climate, volcanic, and regional tectonics since the formation of the lake ca. 600 ka ago. Changes in lake level were determined based on high-resolution seismic reflection profiles showing erosional surfaces, changes in stratal geometries such as downward shifts in coastal onlap, and recognition of distinctive stratigraphic features such as prograding delta clinoforms. Our results show that Lake Van has undergone drastic changes in surface elevation by as much as 600 meters over the past ca. 600 ka. Five major lowstands occurred at ca. ~600 ka, ca. 365-340 ka, ca 290-230 ka; ca. 150-130 ka; and ca. 30-14 ka. During a first period (A) (ca. 600-ca 230 ka) lake levels changed drastically by hundreds of m but at longer time intervals between low and high stands. Changes occurred more frequently but mostly by a few tens of m during the past ca. 230 ka years where we can distinguish a first period (B1) of stepwise transgressions between ca. 230 and 150 ka followed by a short regression between ca. 150 and 130 ka. Lake level rose stepwise again during period B2 lasting until ca 30 ka. During the past 30 ka a regression and a final transgression each lasted ca. 15 ka years. The major lowstand periods in Lake Van occurred during glacial periods, arguing for a climatic control of these lake-level fluctuations (i.e., significantly reduced precipitation leading to lake level low stands). Although climate forcing may have been the dominant cause for the drastic lake level changes of Lake Van, volcanic and tectonic forcing factors are also invoked. For example, the number of distinct tephra layers

PODJETNIŠKA AKTIVNOST NA KOROŠKEM

OpenAIRE

Marhl, Anja

2010-01-01

Da bi se posameznik podal na podjetniško pot mora zaznati poslovno priložnost, hkrati pa mora imeti tudi ustrezno znanje oziroma sposobnosti. Odločitev za podjetništvo je vedno osebna odločitev. Posameznik se mora sam odločiti ali bo deloval kot podjetnik, ali pa se bo ukvarjal s čim drugim. Koroška regija je ena izmed najstarejših slovenskih industrijskih regij. Prevladujejo predelovalne dejavnosti (proizvodnja kovin in kovinskih izdelkov, proizvodnja iz gume in plastike ter proizvodnja ...

NOAA Ship Ka'imimoana Underway Meteorological Data, Near Real Time

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Ship Ka'imimoana Underway Meteorological Data (Near Real Time, updated daily) are from the Shipboard Automated Meteorological and Oceanographic System (SAMOS)...

Determination of the pKa of Benzophenones in Ethanol-Water

Directory of Open Access Journals (Sweden)

G. T. Castro

2000-03-01

Full Text Available The pKa of monohydroxylated benzophenones was determined by UV spectroscopy. The values obtained are coherent with the resonant forms and hydrogen bond intramolecular of the analyzed compounds.

Thermal Runaway of the 13 kA Busbar Joints in the LHC

OpenAIRE

Verweij, A P

2010-01-01

Triggered by the incident in the LHC in September 2008, the thermo-electrical stability of the 10,000 soldered busbar joints in the 13 kA circuits of the LHC has been re-assessed. For this purpose the computer model QP3 has been developed. In this paper the results of some calculations are presented, and it is shown how the results have been used to improve the quench detection system and ensure safe future operation. First the layout of the 13 kA circuits, the geometry of the soldered joints...

DARHT 2 kA Cathode Development

Energy Technology Data Exchange (ETDEWEB)

Henestroza, E.; Houck, T.; Kwan, J.W.; Leitner, M.; Miram, G.; Prichard, B.; Roy, P.K.; Waldron, W.; Westenskow, G.; Yu, S.; Bieniosek, F.M.

2009-03-09

In the campaign to achieve 2 kA of electron beam current, we have made several changes to the DARHT-II injector during 2006-2007. These changes resulted in a significant increase in the beam current, achieving the 2 kA milestone. Until recently (before 2007), the maximum beam current that was produced from the 6.5-inch diameter (612M) cathode was about 1300 A when the cathode was operating at a maximum temperature of 1140 C. At this temperature level, the heat loss was dominated by radiation which is proportional to temperature to the fourth power. The maximum operating temperature was limited by the damage threshold of the potted filament and the capacity of the filament heater power supply, as well as the shortening of the cathode life time. There were also signs of overheating at other components in the cathode assembly. Thus it was clear that our approach to increase beam current could not be simply trying to run at a higher temperature and the preferred way was to operate with a cathode that has a lower work function. The dispenser cathode initially used was the type 612M made by SpectraMat. According to the manufacturer's bulletin, this cathode should be able to produce more than 10 A/cm{sup 2} of current density (corresponding to 2 kA of total beam current) at our operating conditions. Instead the measured emission (space charge limited) was 6 A/cm{sup 2}. The result was similar even after we had revised the activation and handling procedures to adhere more closely to the recommend steps (taking longer time and nonstop to do the out-gassing). Vacuum was a major concern in considering the cathode's performance. Although the vacuum gauges at the injector vessel indicated 10{sup -8} Torr, the actual vacuum condition near the cathode in the central region of the vessel, where there might be significant out-gassing from the heater region, was never determined. Poor vacuum at the surface of the cathode degraded the emission (by raising the work function

DARHT 2 kA Cathode Development

International Nuclear Information System (INIS)

Henestroza, E.; Houck, T.; Kwan, J.W.; Leitner, M.; Miram, G.; Prichard, B.; Roy, P.K.; Waldron, W.; Westenskow, G.; Yu, S.; Bieniosek, F.M.

2009-01-01

In the campaign to achieve 2 kA of electron beam current, we have made several changes to the DARHT-II injector during 2006-2007. These changes resulted in a significant increase in the beam current, achieving the 2 kA milestone. Until recently (before 2007), the maximum beam current that was produced from the 6.5-inch diameter (612M) cathode was about 1300 A when the cathode was operating at a maximum temperature of 1140 C. At this temperature level, the heat loss was dominated by radiation which is proportional to temperature to the fourth power. The maximum operating temperature was limited by the damage threshold of the potted filament and the capacity of the filament heater power supply, as well as the shortening of the cathode life time. There were also signs of overheating at other components in the cathode assembly. Thus it was clear that our approach to increase beam current could not be simply trying to run at a higher temperature and the preferred way was to operate with a cathode that has a lower work function. The dispenser cathode initially used was the type 612M made by SpectraMat. According to the manufacturer's bulletin, this cathode should be able to produce more than 10 A/cm 2 of current density (corresponding to 2 kA of total beam current) at our operating conditions. Instead the measured emission (space charge limited) was 6 A/cm 2 . The result was similar even after we had revised the activation and handling procedures to adhere more closely to the recommend steps (taking longer time and nonstop to do the out-gassing). Vacuum was a major concern in considering the cathode's performance. Although the vacuum gauges at the injector vessel indicated 10 -8 Torr, the actual vacuum condition near the cathode in the central region of the vessel, where there might be significant out-gassing from the heater region, was never determined. Poor vacuum at the surface of the cathode degraded the emission (by raising the work function value). We reexamined

Ka-band SAR interferometry studies for the SWOT mission

Science.gov (United States)

Fernandez, D. E.; Fu, L.; Rodriguez, E.; Hodges, R.; Brown, S.

2008-12-01

The primary objective of the NRC Decadal Survey recommended SWOT (Surface Water and Ocean Topography) Mission is to measure the water elevation of the global oceans, as well as terrestrial water bodies (such as rivers, lakes, reservoirs, and wetlands), to answer key scientific questions on the kinetic energy of ocean circulation, the spatial and temporal variability of the world's surface freshwater storage and discharge, and to provide societal benefits on predicting climate change, coastal zone management, flood prediction, and water resources management. The SWOT mission plans to carry the following suite of microwave instruments: a Ka-band interferometer, a dual-frequency nadir altimeter, and a multi-frequency water-vapor radiometer dedicated to measuring wet tropospheric path delay to correct the radar measurements. We are currently funded by the NASA Earth Science Technology Office (ESTO) Instrument Incubator Program (IIP) to reduce the risk of the main technological drivers of SWOT, by addressing the following technologies: the Ka-band radar interferometric antenna design, the on-board interferometric SAR processor, and the internally calibrated high-frequency radiometer. The goal is to significantly enhance the readiness level of the new technologies required for SWOT, while laying the foundations for the next-generation missions to map water elevation for studying Earth. The first two technologies address the challenges of the Ka-band SAR interferometry, while the high- frequency radiometer addresses the requirement for small-scale wet tropospheric corrections for coastal zone applications. In this paper, we present the scientific rational, need and objectives behind these technology items currently under development.

p Ka determinations of xanthene derivates in aqueous solutions by multivariate analysis applied to UV-Vis spectrophotometric data

Science.gov (United States)

Batistela, Vagner Roberto; Pellosi, Diogo Silva; de Souza, Franciane Dutra; da Costa, Willian Ferreira; de Oliveira Santin, Silvana Maria; de Souza, Vagner Roberto; Caetano, Wilker; de Oliveira, Hueder Paulo Moisés; Scarminio, Ieda Spacino; Hioka, Noboru

2011-09-01

Xanthenes form to an important class of dyes which are widely used. Most of them present three acid-base groups: two phenolic sites and one carboxylic site. Therefore, the p Ka determination and the attribution of each group to the corresponding p Ka value is a very important feature. Attempts to obtain reliable p Ka through the potentiometry titration and the electronic absorption spectrophotometry using the first and second orders derivative failed. Due to the close p Ka values allied to strong UV-Vis spectral overlap, multivariate analysis, a powerful chemometric method, is applied in this work. The determination was performed for eosin Y, erythrosin B, and bengal rose B, and also for other synthesized derivatives such as 2-(3,6-dihydroxy-9-acridinyl) benzoic acid, 2,4,5,7-tetranitrofluorescein, eosin methyl ester, and erythrosin methyl ester in water. These last two compounds (esters) permitted to attribute the p Ka of the phenolic group, which is not easily recognizable for some investigated dyes. Besides the p Ka determination, the chemometry allowed for estimating the electronic spectrum of some prevalent protolytic species and the substituents effects evaluation.

Kui suudab Steve, suudab ka Apple / Tarvo Vaarmets

Index Scriptorium Estoniae

Vaarmets, Tarvo

2008-01-01

Ehkki Apple'i kolmanda kvartali kasum kasvas kolmandiku võrra ja oli oodatust kümnendiku jagu suurem, langes ettevõtte aktsia hind börsil. Investoreid teeb rahutuks nii ettevõtte juhi Steve Jobsi tervis kui ka Apple'i majandusprognoos neljandaks kvartaliks. Lisa: Analüütikud on aktsia suhtes üksmeelel. Diagramm: Aktsia hinnal taas suund alla

Ka-Band, Multi-Gigabit-Per-Second Transceiver

Science.gov (United States)

Simons, Rainee N.; Wintucky, Edwin G.; Smith, Francis J.; Harris, Johnny M.; Landon, David G.; Haddadin, Osama S.; McIntire, William K.; Sun, June Y.

2011-01-01

A document discusses a multi-Gigabit-per-second, Ka-band transceiver with a software-defined modem (SDM) capable of digitally encoding/decoding data and compensating for linear and nonlinear distortions in the end-to-end system, including the traveling-wave tube amplifier (TWTA). This innovation can increase data rates of space-to-ground communication links, and has potential application to NASA s future spacebased Earth observation system. The SDM incorporates an extended version of the industry-standard DVB-S2, and LDPC rate 9/10 FEC codec. The SDM supports a suite of waveforms, including QPSK, 8-PSK, 16-APSK, 32- APSK, 64-APSK, and 128-QAM. The Ka-band and TWTA deliver an output power on the order of 200 W with efficiency greater than 60%, and a passband of at least 3 GHz. The modem and the TWTA together enable a data rate of 20 Gbps with a low bit error rate (BER). The payload data rates for spacecraft in NASA s integrated space communications network can be increased by an order of magnitude (>10 ) over current state-of-practice. This innovation enhances the data rate by using bandwidth-efficient modulation techniques, which transmit a higher number of bits per Hertz of bandwidth than the currently used quadrature phase shift keying (QPSK) waveforms.

"7 vaprat" ei lõpeta ka suvel / H. S.

Index Scriptorium Estoniae

H. S.

2002-01-01

Populaarne muusikaedetabelisaade "7 vaprat" läheb juunis ansamblitega Terminaator, Tuberkuloited, No Big Silence, Blacky, Speed Free ja Hell Can Wait suvetuurile. 11. juunil antakse kontsert Tartus, 12. juunil Rakveres, 13. juunil Pärnus ja 15. juunil Tallinnas. Kontsertidest valmivad ka telesaated, saatejuht Villu Tamme

An integrated Ka/Ku-band payload for personal, mobile and private business communications

Science.gov (United States)

Hayes, Edward J.; Keelty, J. Malcolm

1991-01-01

The Canadian Department of Communications has been studying options for a government-sponsored demonstration payload to be launched before the end of the century. A summary of the proposed system concepts and network architectures for providing an advanced private business network service at Ku-band and personal and mobile communications at Ka-band is presented. The system aspects addressed include coverage patterns, traffic capacity, and grade of service, multiple access options as well as special problems, such as Doppler in mobile applications. Earth terminal types and the advanced payload concept proposed in a feasibility study for the demonstration mission are described. This concept is a combined Ka-band/Ku-band payload which incorporates a number of advanced satellite technologies including a group demodulator to convert single-channel-per-carrier frequency division multiple access uplink signals to a time division multiplex downlink, on-board signal regeneration, and baseband switching to support packet switched data operation. The on-board processing capability of the payload provides a hubless VSAT architecture which permits single-hop full mesh interconnectivity. The Ka-band and Ku-band portions of the payload are fully integrated through an on-board switch, thereby providing the capability for fully integrated services, such as using the Ku-band VSAT terminals as gateway stations for the Ka-band personal and mobile communications services.

Cijepani litički materijal s prapovijesnog nalazišta Slavča, Nova Gradiška

OpenAIRE

Šošić, Rajna; Karavanić, Ivor

2005-01-01

SUMMARY TECHNOLOGICAL AND TYPOLOGICAL ANALYSIS OF THE CHIPPED STONE ARTIFACTS FROM THE PREHISTORIC SITE OF SLAV^A, NOVA GRADI[KA The site of Slav~a is situated on the south flanks of Psunj Mountain, in the town of Nova Gradi{ ka, Western Slavonia. The site has been continuosly excavated since 1997 by the City Museum of Nova Gradi{ka. A total number of 1655 chipped stone artifacts have been analyised, classified to the Sopot, Kostolac and Lasinja cultures, in effect a peri...

Prediction of pKa values using the PM6 semiempirical method

Directory of Open Access Journals (Sweden)

Jimmy C. Kromann

2016-08-01

Full Text Available The PM6 semiempirical method and the dispersion and hydrogen bond-corrected PM6-D3H+ method are used together with the SMD and COSMO continuum solvation models to predict pKa values of pyridines, alcohols, phenols, benzoic acids, carboxylic acids, and phenols using isodesmic reactions and compared to published ab initio results. The pKa values of pyridines, alcohols, phenols, and benzoic acids considered in this study can generally be predicted with PM6 and ab initio methods to within the same overall accuracy, with average mean absolute differences (MADs of 0.6–0.7 pH units. For carboxylic acids, the accuracy (0.7–1.0 pH units is also comparable to ab initio results if a single outlier is removed. For primary, secondary, and tertiary amines the accuracy is, respectively, similar (0.5–0.6, slightly worse (0.5–1.0, and worse (1.0–2.5, provided that di- and tri-ethylamine are used as reference molecules for secondary and tertiary amines. When applied to a drug-like molecule where an empirical pKa predictor exhibits a large (4.9 pH unit error, we find that the errors for PM6-based predictions are roughly the same in magnitude but opposite in sign. As a result, most of the PM6-based methods predict the correct protonation state at physiological pH, while the empirical predictor does not. The computational cost is around 2–5 min per conformer per core processor, making PM6-based pKa prediction computationally efficient enough to be used for high-throughput screening using on the order of 100 core processors.

Accurate pKa calculation of the conjugate acids of alkanolamines, alkaloids and nucleotide bases by quantum chemical methods.

Science.gov (United States)

Gangarapu, Satesh; Marcelis, Antonius T M; Zuilhof, Han

2013-04-02

The pKa of the conjugate acids of alkanolamines, neurotransmitters, alkaloid drugs and nucleotide bases are calculated with density functional methods (B3LYP, M08-HX and M11-L) and ab initio methods (SCS-MP2, G3). Implicit solvent effects are included with a conductor-like polarizable continuum model (CPCM) and universal solvation models (SMD, SM8). G3, SCS-MP2 and M11-L methods coupled with SMD and SM8 solvation models perform well for alkanolamines with mean unsigned errors below 0.20 pKa units, in all cases. Extending this method to the pKa calculation of 35 nitrogen-containing compounds spanning 12 pKa units showed an excellent correlation between experimental and computational pKa values of these 35 amines with the computationally low-cost SM8/M11-L density functional approach. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Maksude tõstmine lööb nii ettevõtlust kui ka tavalist inimest / Mirko Ojakivi

Index Scriptorium Estoniae

Ojakivi, Mirko

2008-01-01

Konjunktuuriinstituudi direktori Marje Josingu sõnul halvendaks maksutõus nii ettevõtluse konkurentsivõimet kui ka inimeste võimet eluga toime tulla, ka maksumaksjate liidu esimees Lasse Lehis peab maksude tõstmist valeks, eriti vale oleks tema väitel tõsta käibemaksu

Full Ka Band Waveguide-to-Microstrip Inline Transition Design

Science.gov (United States)

Li, Jianxing; Li, Lei; Qiao, Yu; Chen, Juan; Chen, Jianzhong; Zhang, Anxue

2018-05-01

In this paper, a compact and broadband inline waveguide-to-microstrip transition is proposed to cover the full Ka band. The transition can be segmented from the electric point of view into three building blocks, comprising a microstrip line to rectangular coaxial line, a wedged rectangular coaxial line to ridged waveguide, and a final tapered ridged waveguide impedance transformer to standard waveguide. Both good electrical performance and simple modular assembly without any soldering have been simultaneously obtained. The validation of the design concept has been conducted by numerical simulations and experimental measurements. The experimental results of a fabricated back-to-back transition prototype coincide with the simulated results. It shows that the proposed transition achieves good return loss of lower than 15.5 dB and low insertion loss with a fluctuation between 0.23 to 0.60 dB across the entire Ka band. Details of design considerations and operation mechanism as well as simulation and measurement results are presented.

Deflation of the cosmological constant associated with inflation and dark energy

International Nuclear Information System (INIS)

Geng, Chao-Qiang; Lee, Chung-Chi

2016-01-01

In order to solve the fine-tuning problem of the cosmological constant, we propose a simple model with the vacuum energy non-minimally coupled to the inflaton field. In this model, the vacuum energy decays to the inflaton during pre-inflation and inflation eras, so that the cosmological constant effectively deflates from the Planck mass scale to a much smaller one after inflation and plays the role of dark energy in the late-time of the universe. We show that our deflationary scenario is applicable to arbitrary slow-roll inflation models. We also take two specific inflation potentials to illustrate our results.

Cosmological Hubble constant and nuclear Hubble constant

International Nuclear Information System (INIS)

Horbuniev, Amelia; Besliu, Calin; Jipa, Alexandru

2005-01-01

The evolution of the Universe after the Big Bang and the evolution of the dense and highly excited nuclear matter formed by relativistic nuclear collisions are investigated and compared. Values of the Hubble constants for cosmological and nuclear processes are obtained. For nucleus-nucleus collisions at high energies the nuclear Hubble constant is obtained in the frame of different models involving the hydrodynamic flow of the nuclear matter. Significant difference in the values of the two Hubble constant - cosmological and nuclear - is observed

Additive manufacturing of Ka-band antennas for wireless communications

DEFF Research Database (Denmark)

Armendariz, Unai; Rommel, Simon; Rodríguez Páez, Juan Sebastián

2016-01-01

This paper presents the design and fabrication of WR-28 waveguide horn antennas operating in the Ka-band frequency range between 26.5 GHz and 40 GHz through 3D printing. Three different antennas are fabricated from polylactide acid filaments in conductive and non-conductive variants; the latter i...

A thermally switched 9 kA superconducting rectifier fluxpump

NARCIS (Netherlands)

ten Kate, Herman H.J.; Bunk, Paul B.; Steffens, Harry A.; van de Klundert, Louis J.M.

1981-01-01

The feasibility of superconducting rectifier-fluxpumps has to be demonstrated at current levels of 10 - 100 kA, where is asked for in the superconducting devices now being planned. An intensive program has been started at the low temperature division of the University of Twente to construct such

Tõnu Talve "Ka" tuuritab Kadrinas ja Rakveres / Ants Juske

Index Scriptorium Estoniae

Juske, Ants, 1956-2016

2005-01-01

Tõnu Talve maalidest. Kadrinas esitatud trio Fragile performance'st ja näitusest tsüklist "Ka" Rakveres. Rakvere näitusel Teele Tuuna ja kolmeaastase tütre Anneliise tööd. Trio Fragile koosseisus on kitarrist Robert Jürjendal, trummar Arvo Urb ja maalija Tõnu Talve

Uusim tehnika annab säästu ka maasoojuspumpades / Lauri Lehtinen

Index Scriptorium Estoniae

Lehtinen, Lauri

2009-01-01

Õhksoojuspumpadega tuntust kogunud inverter- ehk sagedusmuunduriga kompressortehnikat kasutatakse ka uue põlvkonna maasoojuspumpades. Tootjate sõnul annab invertertehnika varasemate seadmetega võrreldes umbes 10–15% kokkuhoidu

Maailma esimene online-maakler teenindab ka eesti keeles / Romet Kreek

Index Scriptorium Estoniae

Kreek, Romet, 1972-

2005-01-01

Maailma esimene online-maaklerfirma E*Trade avas eestikeelse kauplemiskeskkonna, kuhu lähikuudel lisandub võimalus kaubelda ka Eesti aktsiatega. Tabel: E*Trade pakub konkurentsi kohalikele maakleritele. Kommenteerib Peeter Koppel. Vt. samas: Lauri Matsulevitsh. LHV konkurenti ei karda

Tänane heategevuskontsert toetab ka Kiigemetsa kooli / Vaike Käosaar

Index Scriptorium Estoniae

Käosaar, Vaike

2007-01-01

Heategevuskontserdist "Ma olen eriline" Põltsamaa lossihoovis, kus esinevad mitmed Eestimaa tuntud muusikud ja mille tulusid kasutatakse samasuguse pealkirjaga raamatu kirjastamise toetuseks, et aidata peresid, kus kasvab autistlikke lapsi ning Kiigemetsa Kooli, kus õpetatakse teiste seas ka autismipuudega lapsi

Miniaturized Ka-Band Dual-Channel Radar

Science.gov (United States)

Hoffman, James P.; Moussessian, Alina; Jenabi, Masud; Custodero, Brian

2011-01-01

Smaller (volume, mass, power) electronics for a Ka-band (36 GHz) radar interferometer were required. To reduce size and achieve better control over RFphase versus temperature, fully hybrid electronics were developed for the RF portion of the radar s two-channel receiver and single-channel transmitter. In this context, fully hybrid means that every active RF device was an open die, and all passives were directly attached to the subcarrier. Attachments were made using wire and ribbon bonding. In this way, every component, even small passives, was selected for the fabrication of the two radar receivers, and the devices were mounted relative to each other in order to make complementary components isothermal and to isolate other components from potential temperature gradients. This is critical for developing receivers that can track each other s phase over temperature, which is a key mission driver for obtaining ocean surface height. Fully hybrid, Ka-band (36 GHz) radar transmitter and dual-channel receiver were developed for spaceborne radar interferometry. The fully hybrid fabrication enables control over every aspect of the component selection, placement, and connection. Since the two receiver channels must track each other to better than 100 millidegrees of RF phase over several minutes, the hardware in the two receivers must be "identical," routed the same (same line lengths), and as isothermal as possible. This level of design freedom is not possible with packaged components, which include many internal passive, unknown internal connection lengths/types, and often a single orientation of inputs and outputs.

pKa Determination of water-soluble calix[4]arenes

NARCIS (Netherlands)

Shinkai, Seiji; Araki, Koji; Grootenhuis, P.D.J.; Reinhoudt, David

1991-01-01

Neutral, water-soluble 5,11,17,23-tetrakis[bis-(2-hydroxyethyl)aminosulphonyl]calix[4]arene-25,26,27,28-tetraol and 5,11,17,23-tetranitrocalix[4]arene-25,26,27,28-tetraol have been synthesized and the pKa values of the OH groups determined in an aqueous system.

Che legend elab ka 40 aastat hiljem / Evelyn Kaldoja

Index Scriptorium Estoniae

Kaldoja, Evelyn, 1980-

2007-01-01

Ilmunud ka: Postimees : na russkom jazõke 9. okt. lk. 10. Argentinas sündinud ja 1967. aastal hukatud revolutsionääri Ernesto Che Guevara poliitikukarjäärist, tema panusest Kuuba revolutsiooni ja poliitikasse. Ernesto Che Guevara mälestamisest Ladina-Ameeerika riikides. Lisa: Kuuba revolutsioon; Che Guevara elu

Euroopa Liit lubab toetada Afganistani ka tulevikus heldelt / Ahto Lobjakas

Index Scriptorium Estoniae

Lobjakas, Ahto, 1970-

2005-01-01

Euroopa Komisjoni president Jose Manuel Barroso ja Euroopa Liidu ühise välispoliitika peakoordinaator Javier Solana lubasid Afganistani presidendile Hamid Karzaile, et Euroopa Liit jätkab kestva välisabi osutamist riigile ka peale parlamendivalimiste toimumist septembris

Determination of the pKa value of the hydroxyl group in the alpha-hydroxycarboxylates citrate, malate and lactate by 13C NMR: implications for metal coordination in biological systems.

Science.gov (United States)

Silva, Andre M N; Kong, XiaoLe; Hider, Robert C

2009-10-01

Citric acid is an important metal chelator of biological relevance. Citric acid helps solubilizing metals, increasing their bioavailability for plants and microbes and it is also thought to be a constituent of both the extracellular and cytoplasmic low molecular iron pools occurring in plants and vertebrates. Metal coordination by citric acid involves coordination both by the carboxylate and hydroxyl groups, of particular interest is its alpha-hydroxycarboxylate function. This structural feature is highly conserved in siderophores produced by evolutionarily distant species and seems to confer specificity toward Fe(III) binding. In order to understand the mechanism of metal coordination by alpha-hydroxycarboxylates and correctly evaluate the respective complex stability constants, it is essential to improve the knowledge about the ionisation of the alcohol group in these compounds. We have evaluated the hydroxyl pKa value of citric, malic and lactic acids with the objective of understanding the influence of alpha-carbon substitution. Studies at high pH values, utilizing (13)C NMR, permitted estimation of the pKa values for the three acids. The pKa (alcohol) values (14.4 for citric acid, 14.5 for malic acid, and 15.1 for lactic acid) are considerably higher than the previously reported value for citric acid (11.6) but still lower than the value of 15.5 for methanol. A comparative analysis of the three compounds indicates that different substitutions on the alpha-carbon introduce changes to the inductive effect experienced by the hydroxyl group thereby modulating its ionisation behaviour. Comparison with the siderophore rhizoferrin, which pKa (alcohol) values were confirmed to be 10 and 11.3, suggests that intra-molecular hydrogen bonding may also aid in the hydroxyl ionisation by stabilizing the resulting anion. Studies of metal coordination by alpha-hydroxycarboxylates should take these factors into account.

Cilvēka attēlojums nacionālsociālisma laikā: vācu cilvēka tēls plakātos

OpenAIRE

Ziemele, Agnese

2010-01-01

Bakalaura darbā „Cilvēka attēlojums nacionālsociālisma laikā: vācu cilvēka tēls plakātos” tiek noskaidrota sievietes, vīrieša un jaunieša loma sabiedrībā. No 1933. līdz 1945. gadam Vācijā pastāvošā nacionālsociālistiskās ideoloăija ietekmēja propagandas saturu, kā arī noteica sabiedrības locekĜu domāšanas veidu un uzskatus. Darba gaitā tiek aplūkotas tā laika Vācijā valdošās politiskās idejas, mediju un propagandas, kā arī Trešā reiha valodas īpatnības. Darba galvenais pētījumu...

An optimized multi-proxy, multi-site Antarctic ice and gas orbital chronology (AICC2012): 120-800 ka

Science.gov (United States)

Bazin, L.; Landais, A.; Lemieux-Dudon, B.; Toyé Mahamadou Kele, H.; Veres, D.; Parrenin, F.; Martinerie, P.; Ritz, C.; Capron, E.; Lipenkov, V.; Loutre, M.-F.; Raynaud, D.; Vinther, B.; Svensson, A.; Rasmussen, S. O.; Severi, M.; Blunier, T.; Leuenberger, M.; Fischer, H.; Masson-Delmotte, V.; Chappellaz, J.; Wolff, E.

2013-08-01

An accurate and coherent chronological framework is essential for the interpretation of climatic and environmental records obtained from deep polar ice cores. Until now, one common ice core age scale had been developed based on an inverse dating method (Datice), combining glaciological modelling with absolute and stratigraphic markers between 4 ice cores covering the last 50 ka (thousands of years before present) (Lemieux-Dudon et al., 2010). In this paper, together with the companion paper of Veres et al. (2013), we present an extension of this work back to 800 ka for the NGRIP, TALDICE, EDML, Vostok and EDC ice cores using an improved version of the Datice tool. The AICC2012 (Antarctic Ice Core Chronology 2012) chronology includes numerous new gas and ice stratigraphic links as well as improved evaluation of background and associated variance scenarios. This paper concentrates on the long timescales between 120-800 ka. In this framework, new measurements of δ18Oatm over Marine Isotope Stage (MIS) 11-12 on EDC and a complete δ18Oatm record of the TALDICE ice cores permit us to derive additional orbital gas age constraints. The coherency of the different orbitally deduced ages (from δ18Oatm, δO2/N2 and air content) has been verified before implementation in AICC2012. The new chronology is now independent of other archives and shows only small differences, most of the time within the original uncertainty range calculated by Datice, when compared with the previous ice core reference age scale EDC3, the Dome F chronology, or using a comparison between speleothems and methane. For instance, the largest deviation between AICC2012 and EDC3 (5.4 ka) is obtained around MIS 12. Despite significant modifications of the chronological constraints around MIS 5, now independent of speleothem records in AICC2012, the date of Termination II is very close to the EDC3 one.

On Riemannian manifolds (Mn, g) of quasi-constant curvature

International Nuclear Information System (INIS)

Rahman, M.S.

1995-07-01

A Riemannian manifold (M n , g) of quasi-constant curvature is defined. It is shown that an (M n , g) in association with other class of manifolds gives rise, under certain conditions, to a manifold of quasi-constant curvature. Some observations on how a manifold of quasi-constant curvature accounts for a pseudo Ricci-symmetric manifold and quasi-umbilical hypersurface are made. (author). 10 refs

Test results of the 18 kA EDIPO HTS current leads

International Nuclear Information System (INIS)

Wesche, Rainer; Bagnasco, Maurizio; Bruzzone, Pierluigi; Felder, Roland; Guetg, Marc; Holenstein, Manuel; Jenni, Markus; March, Stephen; Roth, Felix; Vogel, Martin

2011-01-01

For the new test facility EDIPO (European DIPOle), to be hosted by CRPP, two 18 kA HTS current leads were manufactured and successfully tested. The HTS module, made of AgMgAu/Bi-2223 tapes, is cooled only by heat conduction to the cold end, while the copper part is cooled by forced flow helium gas. The current leads were tested at low voltage up to the maximum current of 18 kA. The helium mass flow rates required for stable operation at various currents were determined. In addition to the steady state operation, the transient behavior in the case of a loss of flow was studied experimentally. The test results provide an estimate of the operational limits of the EDIPO HTS current leads.

Test results of the 18 kA EDIPO HTS current leads

Energy Technology Data Exchange (ETDEWEB)

Wesche, Rainer, E-mail: rainer.wesche@psi.ch [Ecole Polytechnique Federale de Lausanne (EPFL), Centre de Recherches en Physique des Plasmas (CRPP), Association Euratom - Confederation Suisse, 5232 Villigen PSI (Switzerland); Bagnasco, Maurizio; Bruzzone, Pierluigi; Felder, Roland; Guetg, Marc; Holenstein, Manuel; Jenni, Markus; March, Stephen; Roth, Felix; Vogel, Martin [Ecole Polytechnique Federale de Lausanne (EPFL), Centre de Recherches en Physique des Plasmas (CRPP), Association Euratom - Confederation Suisse, 5232 Villigen PSI (Switzerland)

2011-10-15

For the new test facility EDIPO (European DIPOle), to be hosted by CRPP, two 18 kA HTS current leads were manufactured and successfully tested. The HTS module, made of AgMgAu/Bi-2223 tapes, is cooled only by heat conduction to the cold end, while the copper part is cooled by forced flow helium gas. The current leads were tested at low voltage up to the maximum current of 18 kA. The helium mass flow rates required for stable operation at various currents were determined. In addition to the steady state operation, the transient behavior in the case of a loss of flow was studied experimentally. The test results provide an estimate of the operational limits of the EDIPO HTS current leads.

Kas kollaste kaartide lõpp toob lõpu ka lapsesoodustusele? / Jarno Laur

Index Scriptorium Estoniae

Laur, Jarno, 1975-

2006-01-01

Erastamisväärtpaberite väljaandmise ja kasutamise lõpetamise eelnõust, millega lõpetataks ka lastega seotud 25 000 kroonine hinnasoodustus maa väljaostmisel. Sama ka Vali Uudised 13. jaan. 2005, lk. 2 ; Kuulutaja 13. jaan. 2006, lk. 4 ; Põhjarannik 13. jaan. 2006, lk. 2 ; Lääne Elu 17. jaan. 2006, lk. 2 ; Nädaline 17. jaan. 2006, lk. 2 ; Hiiu Leht 17. jaan. 2006, lk. 2 ; Lõunaleht 19. jaan. 2006, lk. 2 ; Meie Maa 17. jaan. 2006, lk. 2 ; Vooremaa 21. jaan. 2006, lk. 2 ; Virumaa Nädalaleht 13. jaan. 2006, lk. 2 ; Valgamaalane 19. jaan. 2006, lk. 2

Kas läheb ka Ruudi tapmiseks? / Kati Murutar

Index Scriptorium Estoniae

Murutar, Kati, 1967-

2006-01-01

Lastefilm "Ruudi" : stsenaristid Katrin Laur, Aare Toikka, Aarne Mägi : režissöör Katrin Laur : nimiosas lapsnäitleja Paul Oskar Soe : Allfilm - MRP Matila Röhr Productions - Schmidtz Katze Filmkollektiv 2006. Võetud kõne alla ka Peeter Simmi "Kõrini!" ja Peeter Urbla "Stiilipeo" arvustaja meelest teenimatult mahategevad retsensioonid

No surface breaking on the Ecemiş Fault, central Turkey, since Late Pleistocene (~ 64.5 ka); new geomorphic and geochronologic data from cosmogenic dating of offset alluvial fans

Science.gov (United States)

Sarıkaya, M. A.; Yıldırım, C.; Çiner, A.

2015-05-01

The Ecemiş Fault Zone (EF) has been recognized as a major left lateral strike-slip fault in the Central Anatolian Fault Zone (CAFZ) of Turkey. However, its Quaternary slip-rate has been challenging to determine due to the difficulty of dating offset markers. Using high-precision offset measurements and 36Cl cosmogenic nuclide dating, we present the first geochronologically determined Late Quaternary slip-rate for the EF. Our study focuses on the excellent exposures of offset alluvial fan surfaces, originating from the Aladağlar, a Late Quaternary glaciated mountain. Analysis of airborne orthophotogrametry and GNSS (Global Navigation Satellite System) surveys indicates 168 ± 2 m left lateral and 31 ± 1 m vertical displacements. In-situ terrestrial cosmogenic 36Cl geochronology obtained from eleven surface boulders provides a minimum abandonment/incision age of 104.2 ± 16.5 ka for the oldest offset alluvial fan surface. Our geomorphic observations together with Self-potential geophysical surveys revealed the presence of an unfaulted alluvial fan terrace, which allows us to constrain the timing of deformation. The abandonment/incision age of this fan is 64.5 ± 5.6 ka based on thirteen 36Cl depth profile samples. Accordingly, we obtained a geologic fault slip-rate of 4.2 ± 1.9 mm a- 1 horizontally and 0.8 ± 0.3 mm a- 1 vertically for the time frame between 104.2 ± 16.5 ka and 64.5 ± 5.6 ka. Our analysis indicates that the EF has not been producing a major surface breaking earthquake on the main strand at least since 64.5 ± 5.6 ka (mid-Late Pleistocene). This could be the result of abandonment of the main strand and accommodation of deformation by other faults within the EF. Nevertheless, a recently occurred (30 September 2011) low magnitude (ML: 4.3) left lateral strike-slip earthquake indicates recent seismic activity of the EF. Comparison of the recent GPS velocity field with the longer slip history along the CAFZ indicates a constant but low strain

Elucidation of the electronic spectrum changes of KA-Al3+ complex by potentiometric titration, FTIR, 13C NMR and quantum mechanics

International Nuclear Information System (INIS)

Piantavini, Mário S.; Gonçalves, Alan G.; Trindade, Ângela C.L.B.; Noseda, Miguel D.; Mercê, Ana L.R.; Pontarolo, Roberto; Machado, Antonio E.H.

2017-01-01

Kojic acid (KA) is an organic acid widely used in pharmaceutical industry, mainly as a skin lightening agent. Based on the ability of KA to form complexes with ions, we found the most possible kind of complex formed with cation aluminum. KA-Al 3+ complex structures were studied using potentiometric and spectrophotometric (UV) titrations, FTIR and 13 C NMR. The electronic spectroscopy showed that the KA-Al 3+ complexes absorb at higher wavelengths (λ max = 305 nm) than do the non-complexed KA (λ max = 269 nm), confirming complexation. The IR spectra of KA complexed and not complexed allowed to correlate the changes in the absorption of enol and carbonyl groups in absence and presence of Al 3+ in aqueous solutions. The complexation suggested by the potentiometric titration and FTIR spectroscopy are in accordance with the data obtained from NMR results. Calculations based on quantum mechanics were utilized to understand the differences found in the non complexed and complexed KAH electronic spectra. (author)

The potentials for creating sustainable rural tourism in Bačka

Directory of Open Access Journals (Sweden)

Stankov Uglješa

2007-01-01

Full Text Available Average rural household in Bačka mostly depend on agricultural activities. Modern society changes, especially changes in agriculture production imply need for diversification of business activities. Rural tourism can be important part of rural economy for some villages in Bačka. Fertile plain, Danube, Tisa and other smaller rivers, animals and games represent base of natural tourist attractions of rural tourism. However, main competitive advantages of Bačka are anthropogenic values. Traditional pannonian houses, baroques churches, numerous rural festivities, and "melting point" of different nationalities make good base for rural tourism development. Different combinations of rural attractions create several tourist experiences of this region: authentic tourist experience at "szalashes", particular tourist experience in villages, intensive tourist experience of rural events and manifestations, not authentic tourist experiences of pseudo rural attractions and complex tourist experience in rural areas. Regarding to emitive centers of rural tourist demand can be specified tree regions for development of rural tourism - region of Novi Sad, Subotica, and Sombor. Rural tourism can make a valuable contribution to rural economies, job creation, landscape conservation, retention of rural population, support to rural culture and tradition, nature conservation and other. At the same time, rural tourism is facing various limitations. With in this context, rural tourism planning has to include principles of sustainable development.

Nonlinear electrostatic emittance compensation in kA, fs electron bunches

International Nuclear Information System (INIS)

Geer, S.B. van der; Loos, M.J. de; Botman, J.I.M.; Luiten, O.J.; Wiel, M.J. van der

2002-01-01

Nonlinear space-charge effects play an important role in emittance growth in the production of kA electron bunches with a bunch length much smaller than the bunch diameter. We propose a scheme employing the radial third-order component of an electrostatic acceleration field, to fully compensate the nonlinear space-charge effects. This results in minimal transverse root-mean-square emittance. The principle is demonstrated using our design simulations of a device for the production of high-quality, high-current, subpicosecond electron bunches using electrostatic acceleration in a 1 GV/m field. Simulations using the GPT code produce a bunch of 100 pC and 73 fs full width at half maximum pulse width, resulting in a peak current of about 1.2 kA at an energy of 2 MeV. The compensation scheme reduces the root-mean-square emittance by 34% to 0.4π mm mrad

Electromagnetic Properties of Graphene-like Films in Ka-Band

Directory of Open Access Journals (Sweden)

Sofia Voronovich

2014-05-01

Full Text Available We studied electromagnetic properties of pyrolytic carbon (PyC films with thicknesses from 9 nm to 110 nm. The PyC films consisted of randomly oriented and intertwined graphene flakes with a typical size of a few nanometers were synthesized by chemical vapor deposition (CVD at 1100 °C on a quartz substrate. The reflectance and transmittance of these films in Ka-band, 26–37 GHz, were studied both experimentally and theoretically. The discovered remarkably high absorption loss of up to 50% of incident power, along with chemical stability, makes PyC films attractive for electromagnetic (EM interference shielding in space and airspace communication systems, as well as in portable electronic devices occupying this frequency slot. Since, in practical applications, the PyC film should be employed for coating of dielectric surfaces, two important issues to be addressed are: (i which side (front or back of the substrate should be covered to ensure maximum absorption losses; and (ii the frequency dependence of absorbance/transmittance/reflectance of binary PyC/quartz structures in the Ka-band.

Decomposition of atmospheric water content into cluster contributions based on theoretical association equilibrium constants

International Nuclear Information System (INIS)

Slanina, Z.

1987-01-01

Water vapor is treated as an equilibrium mixture of water clusters (H 2 O)/sub i/ using quantum-chemical evaluation of the equilibrium constants of water associations. The model is adapted to the conditions of atmospheric humidity, and a decomposition algorithm is suggested using the temperature and mass concentration of water as input information and used for a demonstration of evaluation of the water oligomer populations in the Earth's atmosphere. An upper limit of the populations is set up based on the water content in saturated aqueous vapor. It is proved that the cluster population in the saturated water vapor, as well as in the Earth's atmosphere for a typical temperature/humidity profile, increases with increasing temperatures

14C ages and activity for the past 50 ka at Volcán Galeras, Colombia

Science.gov (United States)

Banks, N.G.; Calvache, V.M.L.; Williams, S.N.

1997-01-01

Volcán Galeras is the southernmost Colombian volcano with well-recorded historic activity. The volcano is part of a large and complex volcanic center upon which 400,000 people live. Historic activity has centered on a small-volume cone inside the youngest of several large amphitheaters that breach the west flank of the volcano, away from the city of Pasto (population 300,000). Lava flows (SiO2 between 54.6 and 64.7 wt.%) have dominated activity for more than 1 Ma, but explosive events have also occurred. Joint studies by volcanologists from Colombia, Ecuador, Peru, Bolivia, Argentina, and the United States produced 24 new14C ages and more than 100 stratigraphic sections to interpret the past 50 ka of activity at Galeras, including sector collapse events. The youngest collapse event truncated 12.8 ka lava flows and may have occurred as recently as 8 to 10 ka. Tephra-fall material rapidly thins and becomes finer away from the vent area. The only widespread marker in the < 10 ka section is a biotite-bearing tephra deposited between 4.1 and 4.5 ka from a source south of Galeras. It separates cryoturbated from largely undisturbed layers on Galeras, and thus dates a stratigraphic horizon which is useful in the interpretation of other volcanoes and geotectonics in the equatorial Andes. Pyroclastic flows during the past 50 ka have been small to moderate in volume, but they have left numerous thin deposits on the north and east flanks where lava flows have been impeded by crater and amphitheater walls. Many of the pyroclastic-flow deposits are lithic rich, with fines and clasts so strongly altered by hydrothermal action before eruption that they, as well as the sector collapse deposits, resemble waste dumps of leached cappings from disseminated sulfide deposits more than volcanogenic deposits. This evidence of a long-lived hydrothermal system indicates susceptibility to mass failure and explosive events higher than expected for a volcano built largely by lava flows and

Geological Evidences for a Large Tsunami Generated by the 7.3 ka Kikai Caldera Eruption, Southern Japan

Science.gov (United States)

Yamada, M.; Fujino, S.; Satake, K.

2017-12-01

The 7.3 ka eruption of Kikai volcano, southern Kyushu, Japan, is one of the largest caldera-forming eruption in the world. Given that a huge caldera was formed in shallow sea area during the eruption, a tsunami must have been generated by a sea-level change associated. Pyroclastic flow and tsunami deposits by the eruption have been studied around the caldera, but they are not enough to evaluate the tsunami size. The goal of this study is to unravel sizes of tsunami and triggering caldera collapse by numerical simulations based on a widely-distributed tsunami deposit associated with the eruption. In this presentation, we will provide an initial data on distribution of the 7.3 ka tsunami deposit contained in sediment cores taken at three coastal lowlands in Wakayama, Tokushima, and Oita prefectures (560 km, 520 km, and 310 km north-east from the caldera, respectively). A volcanic ash from the eruption (Kikai Akahoya tephra: K-Ah) is evident in organic-rich muddy sedimentary sequence in all sediment cores. Up to 6-cm-thick sand layer, characterized by a grading structure and sharp bed boundary with lower mud, is observed immediately beneath the K-Ah tephra in all study sites. These sedimentary characteristics and broad distribution indicate that the sand layer was most likely deposited by a tsunami which can propagate to a wide area, but not by a local storm surge. Furthermore, the stratigraphic relationship implies that the study sites must have been inundated by the tsunami prior to the ash fall. A sand layer is also evident within the K-Ah tephra layer, suggesting that the sand layer was probably formed by a subsequent tsunami wave during the ash fall. These geological evidences for the 7.3 ka tsunami inundation will contribute to a better understanding of the caldera collapse and the resultant tsunami, but also of the tsunami generating system in the eruptive process.

Pöffi filme näeb ka Ida-Virumaal

Index Scriptorium Estoniae

2005-01-01

Avatakse IX Pimedate Ööde Filmifestivali põhiprogramm, millest osa linastub ka Jõhvis ja Narvas. Lisatud PÖFFi programm Narva kultuurikeskuses Rugodiv ja dokumentaalfilmi "Sügavas kurgus" tutvustus : režissöörid Fenton Bailey, Randy Barbato : Ameerika Ühendriigid 2005. Film käsitleb 1972.a. kurikuulsa pornofilmi "Sügav kurk" ("Deep Throat") fenomeni

Improvement of Ka-band satellite link availability for real-time IP-based video contribution

Directory of Open Access Journals (Sweden)

G. Berretta

2017-09-01

Full Text Available New High Throughput Satellite (HTS systems allow high throughput IP uplinks/contribution at Ka-band frequencies for relatively lower costs when compared to broadcasting satellite uplinks at Ku band. This technology offers an advantage for live video contribution from remote areas, where the terrestrial infrastructure may not be adequate. On the other hand, the Ka-band is more subject to impairments due to rain or bad weather. This paper addresses the target system specification and provides an optimized approach for the transmission of IP-based video flows through HTS commercial services operating at Ka-band frequencies. In particular, the focus of this study is on the service requirements and the propagation analysis that provide a reference architecture to improve the overall link availability. The approach proposed herein leads to the introduction of a new concept of live service contribution using pairs of small satellite antennas and cheap satellite terminals.

Damaška and the faces of international criminal justice

NARCIS (Netherlands)

Swart, B.

2008-01-01

Mirjan Damaška 's scholarly publications provide important insights for the analysis of systems of criminal justice at the international level. This is particularly true for his major book: The Faces of Justice and State Authority - A Comparative Approach to the Legal Process. The book develops

İNAÇ TURİZMİ İŞLEVİYLE GELİŞMEKTE OLAN HAÇKA YAYLASI

OpenAIRE

Çavuş, Ahmet

2013-01-01

Trabzon’a bağlı Düzköy ilçesinde bulunan Haçka Yaylası; Düzköy’e 12, Akçaabat’a 40, Trabzon’a 52 km uzaklıktadır. Yöredeki sevilen ve benimsenen bir din aliminin türbesinin bulunduğu Haçka Yaylası, daha çok inanç turizmi işleviyle gelişme göstermektedir. Trabzon ve çevre iller başta olmak üzere, Türkiye’nin farklı şehirlerinden ziyaretçiler ve yurtdışından gurbetçiler buraya gelmektedir. Haçka Yaylası’nda, 1996’dan beri bu alimi anma törenleri yapılmakta olup, 2011 yılında 16.sı düzenlenen bu...

Test of 60 kA coated conductor cable prototypes for fusion magnets

Science.gov (United States)

Uglietti, D.; Bykovsky, N.; Sedlak, K.; Stepanov, B.; Wesche, R.; Bruzzone, P.

2015-12-01

Coated conductors could be promising materials for the fabrication of the large magnet systems of future fusion devices. Two prototype conductors (flat cables in steel conduits), each about 2 m long, were manufactured using coated conductor tapes (4 mm wide) from Super Power and SuperOx, with a total tape length of 1.6 km. Each flat cable is assembled from 20 strands, each strand consisting of a stack of 16 tapes surrounded by two half circular copper profiles, twisted and soldered. The tapes were measured at 12 T and 4.2 K and the results of the measurements were used for the assessment of the conductor electromagnetic properties at low temperature and high field. The two conductors were assembled together in a sample that was tested in the European Dipole (EDIPO) facility. The current sharing temperatures of the two conductors were measured at background fields from 8 T up to 12 T and for currents from 30 kA up to 70 kA: the measured values are within a few percent of the values expected from the measurements on tapes (short samples). After electromagnetic cycling, T cs at 12 T and 50 kA decreased from about 12 K to 11 K (about 10%), corresponding to less than 3% of I c.

Development of Fruška Gora and some open questions of sustainability

Directory of Open Access Journals (Sweden)

Bajić-Brković Milica

2010-01-01

Full Text Available Future development of Fruška Gora triggers numerous questions from the domain of sustainability. The solutions defined in the spatial plan-PPPPN Fruška Gora 2022, can be carried out only on condition that the current course of spatial planning and space related decision making change, so that the respective procedures become more sensitive to the specific requirements of sustainability. Sustainability by itself affects the way planning is being performed, while the specifics of a concrete case, like the case explored in this paper, set up a particular input relevant for both the conceptual and methodological aspects of planning. The proposals of implementing the specific sustainability-based techniques along with the practical implications of their use throughout the planning process are examined in this paper. Normally, most of them are not part of a standard planning procedure, however, they become highly relevant in cases like Fruška Gora, or similar. A sequence of innovations and possible modifications of/within the existing paradigm proposed here include: the prevention techniques, carrying capacity assessment as it relates to the eco-balance, risk assessment, impact analysis, eco-sensitive zoning, GIS based monitoring, etc. Special attention is given to the issues of physical and environmental quality, as they relate to sustainability.

Theoretical pKa prediction of the α-phosphate moiety of uridine 5‧-diphosphate-GlcNAc

Science.gov (United States)

Vipperla, Bhavaniprasad; Griffiths, Thomas M.; Wang, Xingyong; Yu, Haibo

2017-01-01

The pKa value of the α-phosphate moiety of uridine 5‧-diphosphate-GlcNAc (UDP-GlcNAc) has been successfully calculated using density functional theory methods in conjunction with the Polarizable Continuum Models. Theoretical methods were benchmarked over a dataset comprising of alkyl phosphates. B3LYP/6-31+G(d,p) calculations using SMD solvation model provide excellent agreement with the experimental data. The predicted pKa for UDP-GlcNAc is consistent with most recent NMR studies but much higher than what it has long been thought to be. The importance of this study is evident that the predicted pKa for UDP-GlcNAc supports its potential role as a catalytic base in the substrate-assisted biocatalysis.

Kinase Associated-1 Domains Drive MARK/PAR1 Kinases to Membrane Targets by Binding Acidic Phospholipids

Energy Technology Data Exchange (ETDEWEB)

Moravcevic, Katarina; Mendrola, Jeannine M.; Schmitz, Karl R.; Wang, Yu-Hsiu; Slochower, David; Janmey, Paul A.; Lemmon, Mark A. (UPENN-MED)

2011-09-28

Phospholipid-binding modules such as PH, C1, and C2 domains play crucial roles in location-dependent regulation of many protein kinases. Here, we identify the KA1 domain (kinase associated-1 domain), found at the C terminus of yeast septin-associated kinases (Kcc4p, Gin4p, and Hsl1p) and human MARK/PAR1 kinases, as a membrane association domain that binds acidic phospholipids. Membrane localization of isolated KA1 domains depends on phosphatidylserine. Using X-ray crystallography, we identified a structurally conserved binding site for anionic phospholipids in KA1 domains from Kcc4p and MARK1. Mutating this site impairs membrane association of both KA1 domains and intact proteins and reveals the importance of phosphatidylserine for bud neck localization of yeast Kcc4p. Our data suggest that KA1 domains contribute to coincidence detection, allowing kinases to bind other regulators (such as septins) only at the membrane surface. These findings have important implications for understanding MARK/PAR1 kinases, which are implicated in Alzheimer's disease, cancer, and autism.

Potential constants and centrifugal distortion constants of octahedral hexafluoride molecules

Energy Technology Data Exchange (ETDEWEB)

Manivannan, G [Government Thirumagal Mill' s Coll., Gudiyattam, Tamil Nadu (India)

1981-04-01

The kinetic constants method outlined by Thirugnanasambandham (1964) based on Wilson's (1955) group theory has been adapted in evaluating the potential constants for SF/sub 6/, SeF/sub 6/, WF/sub 6/, IrF/sub 6/, UF/sub 6/, NpF/sub 6/, and PuF/sub 6/ using the experimentally observed vibrational frequency data. These constants are used to calculate the centrifugal distortion constants for the first time.

An optimized multi-proxy, multi-site Antarctic ice and gas orbital chronology (AICC2012: 120–800 ka

Directory of Open Access Journals (Sweden)

L. Bazin

2013-08-01

Full Text Available An accurate and coherent chronological framework is essential for the interpretation of climatic and environmental records obtained from deep polar ice cores. Until now, one common ice core age scale had been developed based on an inverse dating method (Datice, combining glaciological modelling with absolute and stratigraphic markers between 4 ice cores covering the last 50 ka (thousands of years before present (Lemieux-Dudon et al., 2010. In this paper, together with the companion paper of Veres et al. (2013, we present an extension of this work back to 800 ka for the NGRIP, TALDICE, EDML, Vostok and EDC ice cores using an improved version of the Datice tool. The AICC2012 (Antarctic Ice Core Chronology 2012 chronology includes numerous new gas and ice stratigraphic links as well as improved evaluation of background and associated variance scenarios. This paper concentrates on the long timescales between 120–800 ka. In this framework, new measurements of δ18Oatm over Marine Isotope Stage (MIS 11–12 on EDC and a complete δ18Oatm record of the TALDICE ice cores permit us to derive additional orbital gas age constraints. The coherency of the different orbitally deduced ages (from δ18Oatm, δO2/N2 and air content has been verified before implementation in AICC2012. The new chronology is now independent of other archives and shows only small differences, most of the time within the original uncertainty range calculated by Datice, when compared with the previous ice core reference age scale EDC3, the Dome F chronology, or using a comparison between speleothems and methane. For instance, the largest deviation between AICC2012 and EDC3 (5.4 ka is obtained around MIS 12. Despite significant modifications of the chronological constraints around MIS 5, now independent of speleothem records in AICC2012, the date of Termination II is very close to the EDC3 one.

Cataclysmic Rock Avalanche from El Capitan, Yosemite Valley, circa 3.6 ka

Science.gov (United States)

Stock, G. M.

2008-12-01

El Capitan in Yosemite Valley is one of the largest and most iconic granite faces in the world. Despite glacially steepened walls exceeding 90 degrees, a historic database shows relatively few rock falls from El Capitan in the past 150 years. However, a massive bouldery deposit beneath the southeast face suggests an earlier rock avalanche of unusually large size. Spatial analysis of airborne LiDAR data indicate that the rock avalanche deposit has a volume of ~2.70 x 106 m3, a maximum thickness of 18 m, and a runout distance of 660 m, roughly twice the horizontal extent of the adjacent talus. The deposit is very coarse on its distal edge, with individual boulder volumes up to 2500 m3. Cosmogenic 10Be exposure dates from boulders distributed across the deposit confirm this interpretation. Four 10Be samples are tightly clustered between 3.5 and 3.8 ka, with a mean age of 3.6 +/- 0.6 ka. A fifth sample gives a much older age of 22.0 ka, but a glacier occupied Yosemite Valley at this time, prohibiting deposition; thus, the older age likely results from exposure on the cliff face prior to failure. The similarity of ages and overall morphology suggest that the entire deposit formed during a single event. The mean exposure age coincides with inferred Holocene rupture of the northern Owens Valley and/or White Mountain fault(s) between 3.3 and 3.8 ka (Lee et al., 2001; Bacon and Pezzopane, 2007). This time coincidence, combined with the fact that historic rupture of the Owens Valley fault in A.D. 1872 generated numerous large rock falls in Yosemite Valley, strongly suggests that the El Capitan rock avalanche was triggered by a seismic event along the eastern margin of the Sierra Nevada circa 3.6 ka. As there is not an obvious "scar" on the expansive southeast face, the exact source area of the rock avalanche is not yet known. Detrital apatite U-Th/(He) thermochronometry can determine the elevation(s) from which rock fall boulders originate, but significant inter-sample age

Potential forcings of summer temperature variability of the southeastern Tibetan Plateau in the past 12 ka

Science.gov (United States)

Zhang, Enlou; Chang, Jie; Sun, Weiwei; Cao, Yanmin; Langdon, Peter; Cheng, Jun

2018-06-01

Investigating potential forcing mechanisms of terrestrial summer temperature changes from the Asian summer monsoon influenced area is of importance to better understand the climate variability in these densely populated regions. The results of spectral and wavelet analyses of the published chironomid reconstructed mean July temperature data from Tiancai Lake on the SE Tibetan Plateau are presented. The evidence of solar forcing of the summer temperature variability from the site on centennial timescales where key solar periodicities (at 855 ± 40, 465 ± 40, 315 ± 40 and 165 ± 40 year) are revealed. By using a band-pass filter, coherent fluctuations were found in the strength of Asian summer monsoon, Northern Hemisphere high latitude climate and high elevation mid-latitude (26°N) terrestrial temperatures with solar sunspot cycles since about 7.6 ka. The two abrupt cooling events detected from the Tiancai Lake record, centered at ∼9.7 and 3.5 ka were examined respectively. Coupled with the paleoclimate modeling results, the early Holocene event (9.7 ka) is possibly linked to an ocean-atmospheric feedback mechanism whereas the latter event (3.5 ka) may be more directly related to external forcing.

pKa value and buffering capacity of acidic monomers commonly used in self-etching primers.

Science.gov (United States)

Salz, Ulrich; Mücke, Angela; Zimmermann, Jörg; Tay, Franklin R; Pashley, David H

2006-06-01

The aim of this investigation was to characterize acidic monomers used in self-etching primers/adhesives by determination of their pKa values and by calculation of their calcium dissolving capacity in comparison with phosphoric and hydrochloric acid. The following acidic monomers were included in this study: 4-methacryloyloxyethyl trimellitate anhydride (4-META), 10-methacryloyloxydecyl dihydrogen phosphate (MDP), dimethacryloyloxyethyl hydrogen phosphate (di-HEMA-phosphate), ethyl 2-[4-(dihydroxyphosphoryl)-2-oxabutyl]acrylate (EAEPA), 2-[4-(dihydroxyphosphoryl)-2-ox-abutyl]acrylic acid (HAEPA), and 2,4,6 trimethylphenyl 2-[4-(dihydroxyphosphoryl)-2-oxabutyl]acrylate (MAEPA). The pKa values were obtained by titration with 0.1 mol/l NaOH in aqueous solution. The inflection points of the resulting potentiometric titration curve were determined as pKa values. In the case of the sparingly water-soluble acidic monomers MAEPA and 4-META, the co-solvent method using different water/ethanol ratios for MAEPA or water/acetone ratios for 4-META was used. The dissolving capacity of each acidic monomer is defined as the amount of hydroxyapatite (HA) dissolved by 1 g of acid. For each monomer, the HA dissolving capacity was calculated bythe corresponding pKa value and the molecular weight. To confirm the calculated dissolving capacities, increasing amounts of HA powder (100 mg portions) were slowly added to 15 mmol/l aqueous solutions of the monomers to determine how much HA could be dissolved in the acidic solutions. For all the investigated acidic monomers, pKal values between 1.7 to 2.5 were observed. The pKa2 values for the phosphate/phosphonate derivatives are between 7.0 and 7.3, and are comparable to phosphoric acid. For dicarboxylic acid derivatives, the pKa2 values are in the range of 4.2 to 4.5. Due to their comparable molecular weights and pKal values, the three tested acids di-HEMA phosphate, MDP and 4-META all possess comparable dissolving capacities for HA (ie, 0

DelPhiPKa web server: predicting pKa of proteins, RNAs and DNAs.

Science.gov (United States)

Wang, Lin; Zhang, Min; Alexov, Emil

2016-02-15

A new pKa prediction web server is released, which implements DelPhi Gaussian dielectric function to calculate electrostatic potentials generated by charges of biomolecules. Topology parameters are extended to include atomic information of nucleotides of RNA and DNA, which extends the capability of pKa calculations beyond proteins. The web server allows the end-user to protonate the biomolecule at particular pH based on calculated pKa values and provides the downloadable file in PQR format. Several tests are performed to benchmark the accuracy and speed of the protocol. The web server follows a client-server architecture built on PHP and HTML and utilizes DelPhiPKa program. The computation is performed on the Palmetto supercomputer cluster and results/download links are given back to the end-user via http protocol. The web server takes advantage of MPI parallel implementation in DelPhiPKa and can run a single job on up to 24 CPUs. The DelPhiPKa web server is available at http://compbio.clemson.edu/pka_webserver. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Forest cover change and fragmentation using Landsat data in Maçka State Forest Enterprise in Turkey.

Science.gov (United States)

Cakir, Günay; Sivrikaya, Fatih; Keleş, Sedat

2008-02-01

Monitoring forest cover change and understanding the dynamic of forest cover is increasingly important in sustainable development and management of forest ecosystems. This paper uses remote sensing (RS) techniques to monitor forest cover change in Maçka State Forest Enterprise (MSFE) located in NE of Turkey through 1975 to 2000 and then analyses spatial and temporal changes in forest cover by Geographical Information Systems (GIS) and FRAGSTATStrade mark. Forest cover changes were detected from a time series of satellite images of Landsat MSS in 1975, Landsat TM in 1987, and Landsat ETM+ in 2000 using RS and GIS. The results showed that total forest area, productive forest area and degraded forest area increased while broadleaf forest area and non forest area decreased. Mixed forest and degraded forest increased during the first (1975-1987) period, but decreased during the second (1987-2000) period. During the whole study period, the annual forestation rate was 152 ha year(-1), equivalent to 0.27% year(-1) using the compound-interest-rate formula. The total number of patches increased from 36,204 to 48,092 (33%), and mean size of forest patch (MPS) decreased from 2.8 ha to 2.1 ha during a 25 year period. Number of smaller patches (patches in 0-100 ha size class) increased, indicating more fragmented landscape over time that might create a risk for the maintenance of biodiversity of the area. While total population increased from 1975 to 2000 (3.7%), rural population constantly decreased. The increase of forest areas may well be explained by the fact that demographic movement of rural areas concentrated into Maçka City Center. These figures also indicated that decrease in the rural population might likely lead to the release of human pressure to forest areas, probably resulting in a positive development of forest areas.

Veretu retrobuum : [ka TPÜ AR kohvikust] / Allan Hmelnitski

Index Scriptorium Estoniae

Hmelnitski, Allan

2004-01-01

"Ka mina eelistan kõigi söögikohtade seast Teaduste Akadeemia puhvetit, mis on 100% breezhnevi aegne disain - kunstnahast lett, ümmargused madalad lauad, pikk-pikk nahkdiivan, kurgid ja tomatid mis maitsevad hästi ja tugevalt, täpselt nagu aastal 85, hallides ülikondades vanemad härrad vestlemas põlevkivist ja paeklindi ajaloost. Vot see on tõeline petlik naiivsus, turvalisus, rahu, muretus ja stabiilsus nagu aastal 76 ema süles."

Mahepõllumajandus : [1999-2004, ka ökomärgist] / Peeter Prass

Index Scriptorium Estoniae

Prass, Peeter

2005-01-01

Ilmunud ka: Agriculture and the development of rural life : overview 2004/2005. - Tallinn, 2005, lk.43-45. Hinnanguliselt moodustas 2004. a. mahepõllundusega hõivatud maa üldisest põllumajandusmaast alla 5%. Piimalehmadest olid maheloomad veidi üle 2%. Diagrammid

Venezia filmifestivali punane vaip ootab tänavu ka eestlasi / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2007-01-01

Eesti mängufilm "Sügisball" (režissöör Veiko Õunpuu, produtsent Katrin Kissa) esilinastub 7. septembril Venezia 64. filmifestivali konkursiprogrammis Orizzonti. Ka teistest võistlevatest filmidest

Morphotectonic control of the Białka drainage basin (Central Carpathians: Insights from DEM and morphometric analysis.

Directory of Open Access Journals (Sweden)

Wołosiewicz Bartosz

2016-06-01

Full Text Available The Białka river valley is directly related to a deep NNW-SSE oriented fault zone. According to the results of previous morphometric analyses, the Białka drainage basin is one of the most tectonically active zones in the Central Carpathians. It is also located within an area of high seismic activity.

Benthic foraminifera and bottom water evolution in the middle-southern Okinawa Trough during the last 18 ka

Institute of Scientific and Technical Information of China (English)

LI Tiegang; XIANG Rong; SUN Rongtao; CAO Qiyuan

2005-01-01

A piston sediment core E017 from the middle-southern Okinawa Trough was investigated. A preliminary study of the deep-water evolution since 18 cal. ka BP was performed based on the quantitative census data of benthic foraminiferal fauna, together with planktonic foraminiferal oxygen and carbon isotope, AMS14C dating, and the previous results achieved in the southern Okinawa Trough. The result shows that the benthic fauna was dominated by Bulimina aculeata (d'Orbigny), Uvigerina peregrina (Cushman), Hispid Uvigerina and Uvigerina dirupta (Todd) during the glaciation-deglaciation before 9.2 cal. ka BP, while Epistominella exigua (Brady), Pullenia bulloides (d'Orbigny), Cibicidoides hyalina (Hofker), Sphaeroidina bulloides (d'Orbigny) and Globocassidulina subglobosa (Brady) predominated the fauna in the post-glacial period after 9.2 cal. ka BP. The benthic foraminifera accumulation rate (BFAR), paleoproductivity estimates and benthic foraminiferal assemblage conformably indicate that surface water paleoproductivity and organic matter flux during the glaciation-deglaciation were higher than those of the post-glacial period in the middle-southern Okinawa Trough, and gradually enhanced from the southern to the central Okinawa Trough during the glaciation-deglaciation, which could be caused by the discrepancy of the terrigenous nutrients supply. High abundances of E. exigua, an indicator of pulsed organic matter input, after 9.2 cal. ka BP may indicate that the intensity of seasonally riverine pulsed flux during the post-glacial period was stronger than that of the glaciation-deglaciation period, and the seasonal influx in the central trough might be stronger than in the south. The temporal distributions of the typical species indicating bottom water oxygen content and ventilation condition show that the ventilation of the bottom water during the post-glacial period is more active than the glaciation-deglaciation, which reflects that the evolution of the intermediate and

Hydrolysis and formation constants at 250C

International Nuclear Information System (INIS)

Phillips, S.L.

1982-05-01

A database consisting of hydrolysis and formation constants for about 20 metals associated with the disposal of nuclear waste is given. Complexing ligands for the various ionic species of these metals include OH, F, Cl, SO 4 , PO 4 and CO 3 . Table 1 consists of tabulated calculated and experimental values of log K/sub xy/, mainly at 25 0 C and various ionic strengths together with references to the origin of the data. Table 2 consists of a column of recommended stability constants at 25 0 C and zero ionic strength tabulated in the column headed log K/sub xy/(0); other columns contain coefficients for an extended Debye-Huckel equation to permit calculations of stability constants up to 3 ionic strength, and up to 0.7 ionic strength using the Davies equation. Selected stability constants calculated with these coefficients for various ionic strengths agree to an average of +- 2% when compared with published experimental and calculated values

CIA võis lennutada ja hoida vange ka Euroopa idaosas / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2006-01-01

Amnesty Internationali raportis antakse ülevaade kolme vahistatud Jeemeni mehe kogetust aastatel 2003-2005. Meeste tunnistustest järeldab Amnesty, et neid hoiti kinni ka Ida-Euroopas. Lisa: Kolme Jeemeni mehe tunnistused

Riigikogus tehakse ka tööd / Vilja Savisaar

Index Scriptorium Estoniae

Savisaar, Vilja, 1962-

2007-01-01

Ilmunud ka: Sakala, 13. juuni 2007, lk. 2; Lääne Elu, 14. juuni 2007, lk. 2; Põhjarannik, 14. juuni 2007, lk. 2; Severnoje Poberezhje, 14. juuni 2007, lk. 2; Vooremaa, 14. juuni 2007, lk. 2; Harju Ekspress, 15. juuni 2007, lk. 8; Järva Teataja, 16. juuni 2007, lk. 2; Koit, 21. juuni 2007, lk. 6. Parlamendiliige Keskerakonna fraktsiooni poolt parlamendis algatatud eelnõudest

Töötaja leiab ka miinimumpalgaga / Ralf-Martin Soe

Index Scriptorium Estoniae

Soe, Ralf-Martin

2007-01-01

Ilmunud ka: Delovõje Vedomosti 31. okt. lk. 6. Madalate palkade TOP 10. Vt. samas: Küsimustele vastab Helter-R-i tegevjuht Kalev Kivipalu; Madal palk toob kaela maksuameti luubi alla sattumise; Endised töötajad: Helter-R-is sain palka osaliselt sulas; Tagant teine: suur juveelitootja - keskmine palk 3400 krooni kuus; Tagant kolmas koht: maksuamet uuris väikseid palku; Tabel. Kommenteerib Ruth Laatre

Eestil on Euroopas ka oma tee / Jürgen Ligi

Index Scriptorium Estoniae

Ligi, Jürgen, 1959-

2004-01-01

Ilmunud ka: Põhjarannik, 17. apr. 2004, lk. 2; Severnoje Poberezhje, 17. apr. 2004, lk. 2; Koit,17. apr. 2004, lk. 6; Meie Maa, 17. apr. 2004, lk. 2; Hiiu Leht, 20. apr. 2004, lk. 2; Virumaa Nädalaleht, 23. apr. 2004, lk. 2; Sakala, 23. apr. 2004, lk. 2; Valgamaalane, 8. mai 2004, lk. 2. Maksu- ja sotsiaalpoliitika otsustusõigusest ning kaitsmisest EL-i riikides

Malama I Ka `Aina: Fostering the Culture-Science connection

Science.gov (United States)

Bruno, B.; Chinn, P.

2005-12-01

The Malama I Ka `Aina Project (Caring for the land, or sustainability) aims to improve and expand the education of Hawai`i's children by developing and disseminating standards-based, culturally relevant science curricular materials based on an understanding and appreciation of the ways in which traditional Hawaiians interacted with their environment for sustainability. Key concepts include the role of water and the ahupua`a (traditional Hawaiian system of land management), and a culture-based sense of place that includes knowledge of and connection to the land. Elementary, middle, high school and University of Hawai`i teachers work together to develop and implement curricula that are especially relevant to a particular school's science program and issues, e.g., invasive species, students, community and/or geographical location. Participants (typically a mix of teachers, education majors and science majors) enroll in Malama I Ka `Aina, a three-credit course offered through the University of Hawai`i`s Dept. of Curriculum Studies and applicable toward a Bachelor's or Master's degree. This course (team taught by scientists, cultural experts and educational professionals) enables participants to: (1) Study Hawai`i`s unique geology, geography and environmental issues in the context of Hawaiian culture and post Western contact; (2) Use course knowledge to develop, teach and assess Hawaii-oriented, project-based, inquiry activities that address the Hawaii Science Content Standards; (3) Gain an appreciation for the scientific method, and the curiosity that drives science (4) Use educational technology such as PowerPoint, graphing packages and web authoring software to develop electronic resources for educational activities. A sample of the lessons developed by course participants can be found on http://malama.hawaii.edu/schools/index2.html. This project is based at the University of Hawai`i College of Education and funded by an award to P. Chinn by the US Department of

Increasing Diversity in STEM through Ka Hikina O Ka Lā Summer Bridge Program for Native Hawaiian Students

Science.gov (United States)

Coopersmith, A.; Cie, D. K.; Calder, S.; Naho`olewa, D.; Rai, B.

2014-12-01

The Advanced Technology Solar Telescope (ATST) Mitigation Initiative and the Kahikina O Ka Lā Program are NSF-funded projects at the University of Hawai`i Maui College. These projects offer instruction and activities intended to increase diversity in STEM careers. Ke Alahaka, the 2014 summer bridge program, was offered to Native Hawaiian high-school students who indicated an interest in STEM areas. Content workshops were offered in Marine Science, Physics, Biotechnology, and Computer Science and Engineering as well as a Hawaiian Studies course designed to provide a cultural context for the STEM instruction. Focus groups and other program assessments indicate that 50% of the students attending the workshops intend to pursue a STEM major during their undergraduate studies.

Synchronous volcanic eruptions and abrupt climate change ∼17.7 ka plausibly linked by stratospheric ozone depletion.

Science.gov (United States)

McConnell, Joseph R; Burke, Andrea; Dunbar, Nelia W; Köhler, Peter; Thomas, Jennie L; Arienzo, Monica M; Chellman, Nathan J; Maselli, Olivia J; Sigl, Michael; Adkins, Jess F; Baggenstos, Daniel; Burkhart, John F; Brook, Edward J; Buizert, Christo; Cole-Dai, Jihong; Fudge, T J; Knorr, Gregor; Graf, Hans-F; Grieman, Mackenzie M; Iverson, Nels; McGwire, Kenneth C; Mulvaney, Robert; Paris, Guillaume; Rhodes, Rachael H; Saltzman, Eric S; Severinghaus, Jeffrey P; Steffensen, Jørgen Peder; Taylor, Kendrick C; Winckler, Gisela

2017-09-19

Glacial-state greenhouse gas concentrations and Southern Hemisphere climate conditions persisted until ∼17.7 ka, when a nearly synchronous acceleration in deglaciation was recorded in paleoclimate proxies in large parts of the Southern Hemisphere, with many changes ascribed to a sudden poleward shift in the Southern Hemisphere westerlies and subsequent climate impacts. We used high-resolution chemical measurements in the West Antarctic Ice Sheet Divide, Byrd, and other ice cores to document a unique, ∼192-y series of halogen-rich volcanic eruptions exactly at the start of accelerated deglaciation, with tephra identifying the nearby Mount Takahe volcano as the source. Extensive fallout from these massive eruptions has been found >2,800 km from Mount Takahe. Sulfur isotope anomalies and marked decreases in ice core bromine consistent with increased surface UV radiation indicate that the eruptions led to stratospheric ozone depletion. Rather than a highly improbable coincidence, circulation and climate changes extending from the Antarctic Peninsula to the subtropics-similar to those associated with modern stratospheric ozone depletion over Antarctica-plausibly link the Mount Takahe eruptions to the onset of accelerated Southern Hemisphere deglaciation ∼17.7 ka.

Ka-band InSAR Imaging and Analysis Based on IMU Data

Directory of Open Access Journals (Sweden)

Shi Jun

2014-02-01

Full Text Available Compared with other bands, the millimeter wave Interferometric Synthetic Aperture Radar (InSAR has high accuracy and small size, which is a hot topic in InSAR research. On the other hand, shorter wavelength causes difficulties in 2D imaging and interferometric phase extraction. In this study, the imaging and phase performance of the streaming Back Projection (BP method combined with IMU data are analyzed and discussed on the basis of actual Ka-band InSAR data. It is found that because the wavelength of the Ka-band is short, it is more sensitive to the antenna phase-center history. To ensure the phase-preserving capacity, the IMU data must be used with accurate motion error compensation. Furthermore, during data processing, we verify the flat-earth-removing capacity of the BP algorithm that calculates and compensates the master and slave antenna phase centers individually.

Hemp farming development and socioeconomic position of Bačka: Example of Odžaci

Directory of Open Access Journals (Sweden)

Stojanović Vladimir

2016-01-01

Full Text Available Hemp is a very important agricultural crop for Bačka region. For centuries, hemp had been grown in this area and it had a crucial importance not only for the agriculture, but for the industry and trade of this region as well. From uncultivated, poorly inhabited and underdeveloped area in 18th century, Bačka made its way to a promising region in which agriculture and industry represent the backbone of the economic development. Significant number of colonial settlements from 18th century and colonization period during rule of Austro-Hungarian empress Maria Theresa recognized growing hemp as their main opportunities to prosper. Later on, in these settlements, the small manufactories for hemp processing were built which eventually had grown into larger factories for hemp fabric production. The town of Odžaci was one of these settlements. From a small colonial settlement, it became one of the important industrial centres in Bačka region.

Ka-Band MMIC Subarray Technology Program (Ka-Mist)

Science.gov (United States)

Pottinger, W.

1995-01-01

Ka-band monolithic microwave integrated circuit (MMIC) arrays have been considered as having high potential for increasing the capability of space, aircraft, and land mobile communication systems in terms of scan performance, data rate, link margin, and flexibility while offering a significant reduction in size, weight, and power consumption. Insertion of MMIC technology into antenna systems, particularly at millimeter wave frequencies using low power and low noise amplifiers in closed proximity to the radiating elements, offers a significant improvement in the array transmit efficiency, receive system noise figure, and overall array reliability. Application of active array technology also leads to the use of advanced beamforming techniques that can improve beam agility, diversity, and adaptivity to complex signal environments. The objective of this program was to demonstrate the technical feasibility of the 'tile' array packaging architecture at EHF via the insertion of 1990 MMIC technology into a functional tile array or subarray module. The means test of this objective was to demonstrate and deliver to NASA a minimum of two 4 x 4 (16 radiating element) subarray modules operating in a transmit mode at 29.6 GHz. Available (1990) MMIC technology was chosen to focus the program effort on the novel interconnect schemes and packaging requirements rather than focusing on MMIC development. Major technical achievements of this program include the successful integration of two 4 x 4 subarray modules into a single antenna array. This 32 element array demonstrates a transmit EIRP of over 300 watts yielding an effective directive power gain in excess of 55 dB at 29.63 GHz. The array has been actively used as the transmit link in airborne/terrestrial mobile communication experiments accomplished via the ACTS satellite launched in August 1993.

Tüli Euroopa raha pärast mõjutab ka eesti elu / Marianne Mikko

Index Scriptorium Estoniae

Mikko, Marianne, 1961-

2005-01-01

Ilmunud ka: Severnoje Poberezhje 5. juuli, lk. 2, Koit 5. juuli, lk. 6, Võrumaa Teataja 5. juuli, lk. 2, Vooremaa 7. juuli lk. 2, Hiiu Leht 12. juuli lk. 2, Nädaline 12. juuli lk. 4, Sõnumitooja 13. juuli lk. 2, Meie Maa 13. juuli lk. 2, Vali Uudised 15. juuli lk. 2, Virumaa Teataja 26. juuli lk. 7, Sakala 28. juuli lk. 2, Harjumaa 5. august lk. 2. Inglise peaministri Tony Blair'i ja Prantsusmaa presidendi Jacques Chirac'i vaidlustest sõltub ka Eesti põllumehe saatus, kuna Euroopa Liidu eelarvest tulevad tänavu peaaegu kõik põllumajandustoetused

Analysis of Cry8Ka5-binding proteins from Anthonomus grandis (Coleoptera: Curculionidae) midgut.

Science.gov (United States)

Nakasu, Erich Y T; Firmino, Alexandre A P; Dias, Simoni C; Rocha, Thales L; Ramos, Hudson B; Oliveira, Gustavo R; Lucena, Wagner; Carlini, Célia R; Grossi-de-Sá, Maria Fátima

2010-07-01

Biotech crops expressing Bacillus thuringiensis Cry toxins present a valuable approach for insect control. Cry8Ka5, which is highly toxic to the cotton boll weevil (Anthonomus grandis), was used as a model to study toxin-ligand interactions. Three Cry-binding proteins were detected after toxin overlay assays. Following de novo sequencing, a heat-shock cognate protein and a V-ATPase were identified, whilst a approximately 120 kDa protein remained unknown. Additional Cry8Ka5-binding proteins were visualized by two-dimensional gel electrophoresis ligand blots. (c) 2010 Elsevier Inc. All rights reserved.

The 9.2 ka event in Asian summer monsoon area: the strongest millennial scale collapse of the monsoon during the Holocene

Science.gov (United States)

Zhang, Wenchao; Yan, Hong; Dodson, John; Cheng, Peng; Liu, Chengcheng; Li, Jianyong; Lu, Fengyan; Zhou, Weijian; An, Zhisheng

2018-04-01

Numerous Holocene paleo-proxy records exhibit a series of centennial-millennial scale rapid climatic events. Unlike the widely acknowledged 8.2 ka climate anomaly, the likelihood of a significant climate excursion at around 9.2 cal ka BP, which has been notably recognized in some studies, remains to be fully clarified in terms of its magnitude and intensity, as well as its characteristics and spatial distributions in a range of paleoclimatic records. In this study, a peat sediment profile from the Dajiuhu Basin in central China was collected with several geochemical proxies and a pollen analysis carried out to help improve understanding of the climate changes around 9.2 cal ka BP. The results show that the peat development was interrupted abruptly at around 9.2 cal ka BP, when the chemical weathering strength decreased and the tree-pollen declined. This suggests that a strong drier regional climatic event occurred at around 9.2 cal ka BP in central China, which was, in turn, probably connected to the rapid 9.2 ka climate event co-developing worldwide. In addition, based on the synthesis of our peat records and the other Holocene hydrological records from Asian summer monsoon (ASM) region, we further found that the 9.2 ka event probably constituted the strongest abrupt collapse of the Asian monsoon system during the full Holocene interval. The correlations between ASM and the atmospheric 14C production rate, the North Atlantic drift ice records and Greenland temperature indicated that the weakened ASM event at around 9.2 cal ka BP could be interpreted by the co-influence of external and internal factors, related to the changes of the solar activity and the Atlantic Meridional Overturning Circulation (AMOC).

Nonsynonymous substitution rate (Ka is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes

Directory of Open Access Journals (Sweden)

Wang Lei

2011-02-01

Full Text Available Abstract Background Mammalian genome sequence data are being acquired in large quantities and at enormous speeds. We now have a tremendous opportunity to better understand which genes are the most variable or conserved, and what their particular functions and evolutionary dynamics are, through comparative genomics. Results We chose human and eleven other high-coverage mammalian genome data–as well as an avian genome as an outgroup–to analyze orthologous protein-coding genes using nonsynonymous (Ka and synonymous (Ks substitution rates. After evaluating eight commonly-used methods of Ka and Ks calculation, we observed that these methods yielded a nearly uniform result when estimating Ka, but not Ks (or Ka/Ks. When sorting genes based on Ka, we noticed that fast-evolving and slow-evolving genes often belonged to different functional classes, with respect to species-specificity and lineage-specificity. In particular, we identified two functional classes of genes in the acquired immune system. Fast-evolving genes coded for signal-transducing proteins, such as receptors, ligands, cytokines, and CDs (cluster of differentiation, mostly surface proteins, whereas the slow-evolving genes were for function-modulating proteins, such as kinases and adaptor proteins. In addition, among slow-evolving genes that had functions related to the central nervous system, neurodegenerative disease-related pathways were enriched significantly in most mammalian species. We also confirmed that gene expression was negatively correlated with evolution rate, i.e. slow-evolving genes were expressed at higher levels than fast-evolving genes. Our results indicated that the functional specializations of the three major mammalian clades were: sensory perception and oncogenesis in primates, reproduction and hormone regulation in large mammals, and immunity and angiotensin in rodents. Conclusion Our study suggests that Ka calculation, which is less biased compared to Ks and Ka

Are fundamental constants really constant

International Nuclear Information System (INIS)

Norman, E.B.

1986-01-01

Reasons for suspecting that fundamental constants might change with time are reviewed. Possible consequences of such variations are examined. The present status of experimental tests of these ideas is discussed

Regeneration of Vrnjačka Banja and sustainable tourism development

Directory of Open Access Journals (Sweden)

Marić Igor

2005-01-01

Full Text Available The development of Vrnjačka Banja has always been dynamic, starting with its reputation of an elite spa, followed by being a spa for mass medical and other tourist purposes, all up to present days when Banja became the economic center of its municipality, qualified by a number of various functions and interests. With the latest Master Plan for Vrnjačka Banja, the attempt was made to have a better control over space and to meet most of the partial interests. The aim was to "activate" wider area of Banja from central parts to the periphery, and to comprehend Banja in its wider context. Sustainable development as a tall order cannot be attained if its application does not involve a number of other instruments of public action or if it is not in sync with reaching a consensus, which would require a permanent action. In such a context, Master Plan is not an obstacle but a solid basis with significant flexibility for a creative local government.

Convexity and concavity constants in Lorentz and Marcinkiewicz spaces

Science.gov (United States)

Kaminska, Anna; Parrish, Anca M.

2008-07-01

We provide here the formulas for the q-convexity and q-concavity constants for function and sequence Lorentz spaces associated to either decreasing or increasing weights. It yields also the formula for the q-convexity constants in function and sequence Marcinkiewicz spaces. In this paper we extent and enhance the results from [G.J.O. Jameson, The q-concavity constants of Lorentz sequence spaces and related inequalities, Math. Z. 227 (1998) 129-142] and [A. Kaminska, A.M. Parrish, The q-concavity and q-convexity constants in Lorentz spaces, in: Banach Spaces and Their Applications in Analysis, Conference in Honor of Nigel Kalton, May 2006, Walter de Gruyter, Berlin, 2007, pp. 357-373].

Stairs to Skałka. From Iconography of Martyrdom of Bishop Stanislaus

Directory of Open Access Journals (Sweden)

Tomasz Węcławowicz

2003-12-01

Full Text Available For over one hundred years research discussions have revolved around two issues: was Skałka really the site of the martyrdom of bishop Stanislaus, and, what was the church like in its medieval phases: the alleged, pre-Romanesque phase and, confirmed by sources, the Gothic foundation of Casimir the Great. An argument over the site of the martyrdom will turn out to be unimportant if it is considered in two different meanings, two different orders of interpretation. In the historiographic meaning, bishop Stanislaus might have been killed on the Wawel hill, while in the hagiographic meaning, the martyrdom must have taken place on the site called Skałka, outside the town and the Vistula river, in a distant sanctuary of Archangel Gabriel. The latter of the aforementioned research questions - what was the church “Na Skałce’ like in the Middle Ages - was put at the end of the 19th century by Władysław Łuszczkiewicz. In an answer, he presented the churches imagined in the scenes of the Martyrdom of St. Stanislaus in triptychs from St. Mary’s church in Cracow and from a church at Pławno. He understood them as realistic views of Skałka at the beginning of the 16th century A survey of a broad material shows, however, that in the late medieval iconography of St. Stanislaus at least two architectural types of the church which is the background of the Martyrdom scene can be distinguished at the beginning of the 16th century. The question what Skałka was like in reality is a wrong question then and must be left unanswered. The right question is: why was the architectural background of the Martyrdom scene depicted in such different ways, and, was this architecture in its iconographic design really meant to show only the Gothic church ‘Na Skałce’. With varied realisations of details of the church itself, the common motives of all depictions of Skałka are: walls surrounding the hill, gates built in them - one, two or three, always open and

Saja aasta asemel saaks maantee valmis ka kümnega / Jarno Laur

Index Scriptorium Estoniae

Laur, Jarno, 1975-

2006-01-01

Ilmunud ka: Järva Teataja 9. märts lk. 2. Riigikogu liige sotsiaaldemokraatide fraktsiooni poolt Riigikogu menetlusse antud Tallinna-Tartu-Luhamaa maantee ehitamise otsuse eelnõust, otsuse vastuvõtmise vajalikkusest ning tee-ehituse rahastamisest

柴达木盆地大浪滩130ka BP以来的孢粉组合与古气候%Sporo-pollen assemblage and palaeoenvironment since 130 ka BP in Dalangtan Lake of Qaidarn Basin

Institute of Scientific and Technical Information of China (English)

侯献华; 郑绵平; 杨振京; 杨庆华; 毕志伟

2011-01-01

This paper obtained the data of the cores based on U-series age from ZK02 borehole at ridge of Dalangtan in the western Qaidam basin, where 34 samples from the sludge containing gypsum silt were selected of select for 130 ka BP (90.5 m and above) and the pollen analysis was done. Based on the pollen characteristics, the assemblage of the pollen from the bottom upwards can be divided into six zones to analyze the ancient vegetation succession in the last interglacial (130 ka BP) state in this area. The results showed as follows: in the period of 130 ka BP (the last interglacial period), the vegetation in the western Qaidam basin obviously changed compared with the very significant environment. Overall, the spruce, fir and pine trees consisted of some cold temperate coniferous forest had expanded for five times to the surrounded Zhongshan area, and even extends towards the basin. But thegrass of Gramineae, Compositae, Artemisia as the main component occupied the basin, which showed the climate that was mild climate controlled by the summer monsoon flow from the East Asia to the West, while vegetation flourished, the enhanced soil expanded, water being desalinized, the lake larger in the interstadial period, particularly that in the first pollen assemblage I ( 130 -92 ka BP) and the pollen assemblage IV (56.2 -49 ka BP) in the duration of sedimentation when the plant diversity increased. In addition to the grassland vegetation in the basin, on the wetlands around the lake the plant was growing quite flonrishing, which demonstrated that the two periods were the most enhanced summer monsoon circulation with more adequate rainfall and the forest expanding fast in the mountains. The river flow was incresing and salt lake became desaltinized. The emergent grasses were growing at the edge of the marsh in the lake area. In particular in 49 ka BP ago or so, coniferous forest was growing associated with mountain cedar. Thus it suggested that the place was affected by the

A novel miniature superconducting converter for 1 kA magnets

NARCIS (Netherlands)

Chevtchenko, O.A.; Krooshoop, Hendrikus J.G.; ten Kate, Herman H.J.; Fedorovsky, Michael A.

1996-01-01

A miniature full-wave converter to control the current of a superconducting magnet is developed and tested in our institutes. Typical design values of the device are: AC voltage of 35 V, current of 7 A, and frequency 50-60 Hz; DC voltage o f f 0.2 V, and current of * 1 kA. An efficiency is better

Reconstruction of the eruptive activity on the NE sector of Stromboli volcano: timing of flank eruptions since 15 ka

NARCIS (Netherlands)

Calvari, S.; Branca, S.; Corsaro, R.A.; De Beni, E.; Miraglia, L.; Norini, G.; Wijbrans, J.R.; Boschi, E.

2011-01-01

A multidisciplinary geological and compositional investigation allowed us to reconstruct the occurrence of flank eruptions on the lower NE flank of Stromboli volcano since 15 ka. The oldest flank eruption recognised is Roisa, which occurred at ~15 ka during the Vancori period, and has transitional

High Efficiency Ka-Band Spatial Combiner

Directory of Open Access Journals (Sweden)

D. Passi

2014-12-01

Full Text Available A Ka-Band, High Efficiency, Small Size Spatial Combiner (SPC is proposed in this paper, which uses an innovatively matched quadruple Fin Lines to microstrip (FLuS transitions. At the date of this paper and at the Author's best knowledge no such FLuS innovative transitions have been reported in literature before. These transitions are inserted into a WR28 waveguide T-junction, in order to allow the integration of 16 Monolithic Microwave Integrated Circuit (MMIC Solid State Power Amplifiers (SSPA's. A computational electromagnetic model using the finite elements method has been implemented. A mean insertion loss of 2 dB is achieved with a return loss better the 10 dB in the 31-37 GHz bandwidth.

pKa values of hyodeoxycholic and cholic acids in the binary mixed micelles sodium-hyodeoxycholate-Tween 40 and sodium-cholate-Tween 40: Thermodynamic stability of the micelle and the cooperative hydrogen bond formation with the steroid skeleton.

Science.gov (United States)

Poša, Mihalj; Pilipović, Ana; Bećarević, Mirjana; Farkaš, Zita

2017-01-01

Due to a relatively small size of bile acid salts, their mixed micelles with nonionic surfactants are analysed. Of the special interests are real binary mixed micelles that are thermodynamically more stable than ideal mixed micelles. Thermodynamic stability is expressed with an excess Gibbs energy (G E ) or over an interaction parameter (β ij ). In this paper sodium salts of cholic (C) and hyodeoxycholic acid (HD) in their mixed micelles with Tween 40 (T40) are analysed by potentiometric titration and their pKa values are determined. Examined bile acids in mixed micelles with T40 have higher pKa values than free bile acids. The increase of ΔpKa acid constant of micellary bound C and HD is in a correlation with absolute values of an interaction parameter. According to an interaction parameter and an excess Gibbs energy, mixed micelle HD-T40 are thermodynamically more stable than mixed micelles C-T40. ΔpKa values are higher for mixed micelles with Tween 40 whose second building unit is HD, related to the building unit C. In both micellar systems, ΔpKa increases with the rise of a molar fraction of Tween 40 in binary mixtures of surfactants with sodium salts of bile acids. This suggests that, ΔpKa can be a measure of a thermodynamic stabilization of analysed binary mixed micelles as well as an interaction parameter. ΔpKa values are confirmed by determination of a distribution coefficient of HD and C in systems: water phase with Tween 40 in a micellar concentration and 1-octanol, with a change of a pH value of a water phase. Conformational analyses suggests that synergistic interactions between building units of analysed binary micelles originates from formation of hydrogen bonds between steroid OH groups and polyoxyethylene groups of the T40. Relative similarity and spatial orientation of C 3 and C 6 OH group allows cooperative formation of hydrogen bonds between T40 and HD - excess entropy in formation of mixed micelle. If a water solution of analysed binary

Ettevõtja saab raha ka otse Brüsselist / Silva Männik

Index Scriptorium Estoniae

Männik, Silva, 1974-

2004-01-01

Lisaks mitmetele Eesti asutustele, mis alates sellest aastast EL-i struktuurifondide kaudu raha jagama hakkavad, on ettevõtjatel võimalik taotleda erinevate programmide kaudu raha ka otse EL-i eelarvest. Lisa: Otse saab raha taotleda mitmest programmist

Kolem Patočkovy politiky duchovního člověka

Czech Academy of Sciences Publication Activity Database

Chvatík, Ivan

2015-01-01

Roč. 70, č. 6 (2015), s. 458-464 ISSN 0046-385X Institutional support: RVO:67985955 Keywords : philosophy * upswing to the political * meaning * history * solidarity of the shaken * Patočka Subject RIV: AA - Philosophy ; Religion

Thermal decay of the cosmological constant into black holes

International Nuclear Information System (INIS)

Gomberoff, Andres; Henneaux, Marc; Teitelboim, Claudio; Wilczek, Frank

2004-01-01

We show that the cosmological constant may be reduced by thermal production of membranes by the cosmological horizon, analogous to a particle 'going over the top of the potential barrier', rather than tunneling through it. The membranes are endowed with charge associated with the gauge invariance of an antisymmetric gauge potential. In this new process, the membrane collapses into a black hole; thus, the net effect is to produce black holes out of the vacuum energy associated with the cosmological constant. We study here the corresponding Euclidean configurations ('thermalons') and calculate the probability for the process in the leading semiclassical approximation

New Variant of the Universal Constants in the Perturbed Chain-Statistical Associating Fluid Theory Equation of State

DEFF Research Database (Denmark)

Liang, Xiaodong; Kontogeorgis, Georgios

2015-01-01

The Perturbed Chain-Statistical Associating Fluid Theory Equation of State (PC-SAFT EOS) has been successfully applied to model phase behavior of various types of systems, while it is also well-known that the PC-SAFT EOS has difficulties in describing some second-order derivative properties...... resolved the mostly criticized numerical pitfall, that is, the presence of more than three volume roots at real application conditions. Finally, the possibility of using the original PC-SAFT EOS parameters with the new universal constants has been investigated for the phase equilibria of the systems...

MMIC for High-Efficiency Ka-BAnd GaN Power Amplifiers (2007043), Phase I

Data.gov (United States)

National Aeronautics and Space Administration — This proposal addresses the need for high-efficiency, high-output power amplifiers operating in the Ka-band frequencies. For space communications, the power...

Elucidation of the electronic spectrum changes of KA-Al{sup 3+} complex by potentiometric titration, FTIR, {sup 13}C NMR and quantum mechanics

Energy Technology Data Exchange (ETDEWEB)

Piantavini, Mário S.; Gonçalves, Alan G.; Trindade, Ângela C.L.B.; Noseda, Miguel D.; Mercê, Ana L.R.; Pontarolo, Roberto, E-mail: pontarolo@ufpr.br [Universidade Federal do Paraná (UFPR), Curitiba (Brazil); Machado, Antonio E.H. [Universidade Federal de Uberlândia (UFU), MG (Brazil)

2017-08-15

Kojic acid (KA) is an organic acid widely used in pharmaceutical industry, mainly as a skin lightening agent. Based on the ability of KA to form complexes with ions, we found the most possible kind of complex formed with cation aluminum. KA-Al{sup 3+} complex structures were studied using potentiometric and spectrophotometric (UV) titrations, FTIR and {sup 13}C NMR. The electronic spectroscopy showed that the KA-Al{sup 3+} complexes absorb at higher wavelengths (λ{sub max}= 305 nm) than do the non-complexed KA (λ{sub max}= 269 nm), confirming complexation. The IR spectra of KA complexed and not complexed allowed to correlate the changes in the absorption of enol and carbonyl groups in absence and presence of Al{sup 3+} in aqueous solutions. The complexation suggested by the potentiometric titration and FTIR spectroscopy are in accordance with the data obtained from NMR results. Calculations based on quantum mechanics were utilized to understand the differences found in the non complexed and complexed KAH electronic spectra. (author)

A 25 kA, 2T, 78 kJ, 52 litre superconducting test coil. Strength calculations and construction

NARCIS (Netherlands)

ten Kate, Herman H.J.; Holtslag, A.H.M.; Knoben, J.; Steffens, H.A.; van de Klundert, L.J.M.

1983-01-01

Within the scope of our research program for a 25 kA superconducting rectifier, we have built a 25 kA s.c. coil being a single layer solenoid with a bore of 0.45 meter and a volume of 52 litre. The starting point for the design was to avoid any metallic structural material. This unique coil consists

Jan Patočka: fenomenología asubjetiva y filosofía herética de la Historia

Directory of Open Access Journals (Sweden)

Ortega Rodríguez, Iván

2009-04-01

Full Text Available Our aim is to present the thought of Jan Patočka and the philosophical debates stimulated by his positions. The core of his thought is, on our opinion, human existence as essentially transcending the given and disclosing its essential freedom. Patočka’s phenomenological research seeks an “asubjective phenomenology” and a conceptualization of existence as movement (diversified in the three movements of human existence. In Philosophy of History, Patočka focuses on the origins of Europe and at the essential transformations which have led to an absolute dominion of technical reason. In this situation, only sacrifice seems to offer a possibility to counter the absoluteness of technical civilisation. Finally, we confront Patočka and Lévinas, and we show that a fundamental debate between ontological pluralism and ontological monism is stirred. This debate is of essential importance in the fields of Ethics and Politics. Patočka’s thought is, then, an example of how phenomenology is still timely.Nuestro objetivo es presentar el pensamiento de Jan Patočka y los debates filosóficos que suscitan sus posiciones. El núcleo de su pensamiento, a nuestro juicio, es la existencia humana como esencialmente trascendiendo lo dado y descubriendo en ello su esencial libertad. La investigación fenomenológica de Patočka busca una fenomenología “asubjetiva” y conceptuar la existencia como movimiento (diversificado en los tres movimientos de la existencia humana. La filosofía de la historia apunta a los orígenes de Europa, así como a las transformaciones esenciales que han llevado a un dominio absoluto de la razón técnica. En esta situación, sólo el sacrificio parece poder contrarrestar la civilización técnica. Finalmente, confrontamos a Patočka con Levinas, mostrando cómo se suscita un debate fundamental entre el monismo y el pluralismo ontológico. Este debate tiene una importancia crucial la Ética y la Política El pensamiento de

Ka-Band, MEMS Switched Line Phase Shifters Implemented in Finite Ground Coplanar Waveguide

Science.gov (United States)

Scardelletti, Maximilian C.; Ponchak, George E.; Varaljay, Nicholas C.

2005-01-01

Ka-band MEMS switched line phase shifters implemented in finite ground coplanar waveguide are described in this paper. The phase shifters are constructed of single-pole double-throw (SPDT) switches with additional reference and phase offset transmission line lengths. The one- and two-bit phase shifters are fabricated on high resistivity (HR) silicon with a dielectric constant, Epsilon(sub T) = 11.7 and a substrate thickness, t = 500microns. The switching architectures integrated within the phase shifters consist of MEMS switches that are doubly anchored cantilever beam capacitive switches with additional high inductive sections (MEMS LC device). The SPDT switch is composed of a T-junction with a MEMS LC device at each output port. The one-bit phase shifter described in this paper has an insertion loss (IL) and return loss (RL) of 0.9 dB and 30 dB while the two-bit described has an IL and RL of 1.8 dB and 30 dB respectively. The one-bit phase shifter's designed offset phase is 22.5deg and actual measured phase shift is 21.8deg. The two-bit phase shifter's designed offset phase is 22.5deg, 45deg, and 67.5deg and the actual measured phase shifts are 21.4deg, 44.2deg, and 65.8deg, respectively.

A Novel Low-cost, Ka-band, High Altitude, Multi-Baseline Unmanned Aerial Vehicle Sensor for Surface Water Ocean Topography, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — This proposal presents the Ka-band SWOT Phenomenology Airborne Radar (KaSPAR) to support the surface water ocean topography (SWOT) mission for science and algorithm...

Hyaluronic Acid Injections in Medicare Knee Osteoarthritis Patients Are Associated With Longer Time to Knee Arthroplasty.

Science.gov (United States)

Ong, Kevin L; Anderson, Allen F; Niazi, Faizan; Fierlinger, Anke L; Kurtz, Steven M; Altman, Roy D

2016-08-01

Few nonoperative treatment options for knee osteoarthritis (OA) are available, but there is ongoing debate about the effectiveness of intra-articular (IA) hyaluronic acid (HA) injections. We investigated whether the formulation of IA HA, or its combined use with IA corticosteroid (CS), may be contributing to some of the reported variation in clinical outcomes. The 5% Part B Medicare data (2005-2012) were used to identify knee OA patients who underwent knee arthroplasty (KA). The time from diagnosis of OA to KA was compared between patients with (HA) and without (no HA) IA HA use, using quantile regression with propensity score adjustment. These were further stratified by type of IA HA. Patient factors associated with time to KA were also assessed using Cox regression. The "HA" cohort was associated with a longer time to KA of 8.7 months (95% confidence interval: 8.3-9.1 months; P injection use. Patients with both IA HA and IA CS had an additional 6.3 months (95% confidence interval: 5.5-7.0 months; P < .001) to KA over those with only IA HA. In a large cohort of elderly patients undergoing KA, there was a significant longer time from diagnosis of OA to KA in those receiving IA HA. It is unclear if the extended time may lead to less KA utilization. Copyright © 2016 Elsevier Inc. All rights reserved.

A New Blind Pointing Model Improves Large Reflector Antennas Precision Pointing at Ka-Band (32 GHz)

Science.gov (United States)

Rochblatt, David J.

2009-01-01

The National Aeronautics and Space Administration (NASA), Jet Propulsion Laboratory (JPL)-Deep Space Network (DSN) subnet of 34-m Beam Waveguide (BWG) Antennas was recently upgraded with Ka-Band (32-GHz) frequency feeds for space research and communication. For normal telemetry tracking a Ka-Band monopulse system is used, which typically yields 1.6-mdeg mean radial error (MRE) pointing accuracy on the 34-m diameter antennas. However, for the monopulse to be able to acquire and lock, for special radio science applications where monopulse cannot be used, or as a back-up for the monopulse, high-precision open-loop blind pointing is required. This paper describes a new 4th order pointing model and calibration technique, which was developed and applied to the DSN 34-m BWG antennas yielding 1.8 to 3.0-mdeg MRE pointing accuracy and amplitude stability of 0.2 dB, at Ka-Band, and successfully used for the CASSINI spacecraft occultation experiment at Saturn and Titan. In addition, the new 4th order pointing model was used during a telemetry experiment at Ka-Band (32 GHz) utilizing the Mars Reconnaissance Orbiter (MRO) spacecraft while at a distance of 0.225 astronomical units (AU) from Earth and communicating with a DSN 34-m BWG antenna at a record high rate of 6-megabits per second (Mb/s).

On the Performance of Adaptive Data Rate over Deep Space Ka-Bank Link: Case Study Using Kepler Data

Science.gov (United States)

Gao, Jay L.

2016-01-01

Future missions envisioned for both human and robotic exploration demand increasing communication capacity through the use of Ka-band communications. The Ka-band channel, being more sensitive to weather impairments, presents a unique trade-offs between data storage, latency, data volume and reliability. While there are many possible techniques for optimizing Ka-band operations such as adaptive modulation and coding and site-diversity, this study focus exclusively on the use of adaptive data rate (ADR) to achieve significant improvement in the data volume-availability tradeoff over a wide range of link distances for near Earth and Mars exploration. Four years of Kepler Ka-band downlink symbol signal-to-noise (SNR) data reported by the Deep Space Network were utilized to characterize the Ka-band channel statistics at each site and conduct various what-if performance analysis for different link distances. We model a notional closed-loop adaptive data rate system in which an algorithm predicts the channel condition two-way light time (TWLT) into the future using symbol SNR reported in near-real time by the ground receiver and determines the best data rate to use. Fixed and adaptive margins were used to mitigate errors in channel prediction. The performance of this closed-loop adaptive data rate approach is quantified in terms of data volume and availability and compared to the actual mission configuration and a hypothetical, optimized single rate configuration assuming full a priori channel knowledge.

Proton and metal ion binding to natural organic polyelectrolytes-I. Studies with synthetic model compounds

Science.gov (United States)

Marinsky, J.A.; Reddy, M.M.

1984-01-01

A unified physico-chemical model, based on a modified Henderson-Hasselbalch equation, for the analysis of ion complexation reactions involving charged polymeric systems is presented and verified. In this model pH = pKa+p(??Ka) + log(??/1 - ??) where Ka is the intrinsic acid dissociation constant of the ionizable functional groups on the polymer, ??Ka is the deviation of the intrinsic constant due to electrostatic interaction between the hydrogen ion and the polyanion, and alpha (??) is the polyacid degree of ionization. Using this approach pKa values for repeating acidic units of polyacrylic (PAA) and polymethacrylic (PMA) acids were found to be 4.25 ?? 0.03 and 4.8 ?? 0.1, respectively. The polyion electrostatic deviation term derived from the potentiometric titration data (i.e. p(??Ka)) is used to calculate metal ion concentration at the complexation site on the surface of the polyanion. Intrinsic cobalt-polycarboxylate binding constants (7.5 for PAA and 5.6 for PMA), obtained using this procedure, are consistent with the range of published binding constants for cobalt-monomer carboxylate complexes. In two phase systems incorporation of a Donnan membrane potential term allows determination of the intrinsic pKa of a cross-linked PMA gel, pKa = 4.83, in excellent agreement with the value obtained for the linear polyelectrolyte and the monomer. Similarly, the intrinsic stability constant for cobalt ion binding to a PMA-gel (??CoPMA+ = 11) was found to be in agreement with the linear polyelectrolyte analogue and the published data for cobalt-carboxylate monodentate complexes. ?? 1984.

Best of both worlds: combining pharma data and state of the art modeling technology to improve in Silico pKa prediction.

Science.gov (United States)

Fraczkiewicz, Robert; Lobell, Mario; Göller, Andreas H; Krenz, Ursula; Schoenneis, Rolf; Clark, Robert D; Hillisch, Alexander

2015-02-23

In a unique collaboration between a software company and a pharmaceutical company, we were able to develop a new in silico pKa prediction tool with outstanding prediction quality. An existing pKa prediction method from Simulations Plus based on artificial neural network ensembles (ANNE), microstates analysis, and literature data was retrained with a large homogeneous data set of drug-like molecules from Bayer. The new model was thus built with curated sets of ∼14,000 literature pKa values (∼11,000 compounds, representing literature chemical space) and ∼19,500 pKa values experimentally determined at Bayer Pharma (∼16,000 compounds, representing industry chemical space). Model validation was performed with several test sets consisting of a total of ∼31,000 new pKa values measured at Bayer. For the largest and most difficult test set with >16,000 pKa values that were not used for training, the original model achieved a mean absolute error (MAE) of 0.72, root-mean-square error (RMSE) of 0.94, and squared correlation coefficient (R(2)) of 0.87. The new model achieves significantly improved prediction statistics, with MAE = 0.50, RMSE = 0.67, and R(2) = 0.93. It is commercially available as part of the Simulations Plus ADMET Predictor release 7.0. Good predictions are only of value when delivered effectively to those who can use them. The new pKa prediction model has been integrated into Pipeline Pilot and the PharmacophorInformatics (PIx) platform used by scientists at Bayer Pharma. Different output formats allow customized application by medicinal chemists, physical chemists, and computational chemists.

HPLC ve Kağıt Kromatografisi Tekniklerinin Kombinasyonu ile Flavonoidlerin Saflaştırılması

OpenAIRE

Velioğlu, Sedat; Cemeroğlu, Bekir

1992-01-01

Bu araştırmada, kağıt kromatografisi ve yüksek basınç likit kromatografisi (HPLC) yöntemlerinin birlikte uygulanması ile flavonoidlerin saf olarak elde edilme olanakları incelenmiştir. Whatman 3MM kromatografi kağıdı ve BAW solvent sistemi kullanılarak inen tipte kağıt kromatografisi tekniğiyle 7 band elde edilmiş ve bu bantlar üzerindeki flavonoidler MAW solvent sistemiyle elue edildikten sonra HPLC kolonuna enjekte edilmiştir. Araştırma bulguları, bu yolla 15 adet pikin saf olarak elde edil...

Paleoclimate in continental northwestern Europe during the Eemian and early Weichselian (125-97 ka): insights from a Belgian speleothem

Science.gov (United States)

Vansteenberge, Stef; Verheyden, Sophie; Cheng, Hai; Edwards, R. Lawrence; Keppens, Eddy; Claeys, Philippe

2016-07-01

The last interglacial serves as an excellent time interval for studying climate dynamics during past warm periods. Speleothems have been successfully used for reconstructing the paleoclimate of last interglacial continental Europe. However, all previously investigated speleothems are restricted to southern Europe or the Alps, leaving large parts of northwestern Europe undocumented. To better understand regional climate changes over the past, a larger spatial coverage of European last interglacial continental records is essential, and speleothems, because of their ability to obtain excellent chronologies, can provide a major contribution. Here, we present new, high-resolution data from a stalagmite (Han-9) obtained from the Han-sur-Lesse Cave in Belgium. Han-9 formed between 125.3 and ˜ 97 ka, with interruptions of growth occurring at 117.3-112.9 and 106.6-103.6 ka. The speleothem was investigated for its growth, morphology and stable isotope (δ13C and δ18O) composition. The speleothem started growing relatively late within the last interglacial, at 125.3 ka, as other European continental archives suggest that Eemian optimum conditions were already present during that time. It appears that the initiation of Han-9 growth is caused by an increase in moisture availability, linked to wetter conditions around 125.3 ka. The δ13C and δ18O proxies indicate a period of relatively stable conditions after 125.3 ka; however, at 120 ka the speleothem δ18O registered the first signs of regionally changing climate conditions, being a modification of ocean source δ18O linked to an increase in ice volume towards the Marine Isotope Stage (MIS) 5e-5d transition. At 117.5 ka, drastic vegetation changes are recorded by Han-9 δ13C immediately followed by a cessation of speleothem growth at 117.3 ka, suggesting a transition to significantly dryer conditions. The Han-9 record covering the early Weichselian displays larger amplitudes in both isotope proxies and changes in stalagmite

Müügiga kimpus majaomanikud otsivad samal ajal ka rentnikke / Kaire Talviste

Index Scriptorium Estoniae

Talviste, Kaire, 1979-

2008-01-01

Olukorrast eramute üüriturul: kinnisvaraportaalides on rendile pakkuda ligi paarsada maja, mida püütakse samal ajal ka edutult müüa, rendihinnad ulatuvad 30 000 - 50 000 kroonini kuus, eramuid üürivad peamiselt välismaalased

Quaternary geologic map of the north-central part of the Salinas River Valley and Arroyo Seco, Monterey County, California

Science.gov (United States)

Taylor, Emily M.; Sweetkind, Donald S.

2014-01-01

Arroyo Seco, a perennial drainage in the central Coast Range of California, records a sequence of strath terraces. These terraces preserve an erosional and depositional history, controlled by both climate change and regional tectonics. These deposits have been mapped and correlated on the basis of field investigations, digital terrain analysis, stream gradient profiles, evaluation of published regional soil maps, and satellite imagery. Seven of the strath terraces and associated alluvial fans have been dated by optically stimulated luminescence (OSL) or infrared stimulated luminescence (IRSL). The OSL and IRSL dates on seven of the strath terraces and associated alluvial fans in Arroyo Seco are approximately >120 ka, >65 ka, 51–46 ka, 36–35 ka, 9 ka, and 2–1 ka. These dates generally fall within the range of ages reported from many well-dated marine terraces on the California coast that are formed during sea-level high stands. Tectonic movements, consistently upward, result in a constantly and slowly emerging coastline, however, the regional effects of climate change and resulting eustatic sea-level rises are interpreted as the driving mechanism for erosion and aggradation in Arroyo Seco.

Geological conditions of origin of the Potočka zijalka cave

Directory of Open Access Journals (Sweden)

Stanko Buser

2002-12-01

Full Text Available In the Potočka zijalka cave on Mt. Ol{eva in Southern Karavanke during excavation of cave sediments of Würm age that contain cultural remains of the Cromagnon Man also large amounts of gravel were before the Badenian transgression, from the Central Alps during Miocene.

A role for icebergs in the 8.2 ka climate event

NARCIS (Netherlands)

Wiersma, A.P.; Jongma, J.I.

2009-01-01

We investigate the potential role of icebergs in the 8.2 ka climate event, using a coupled climate model equipped with an iceberg component. First, we evaluate the effect of a large iceberg discharge originating from the decaying Laurentide ice sheet on ocean circulation, compared to a release of an

Partially Observable Markov Decision Process-Based Transmission Policy over Ka-Band Channels for Space Information Networks

Directory of Open Access Journals (Sweden)

Jian Jiao

2017-09-01

Full Text Available The Ka-band and higher Q/V band channels can provide an appealing capacity for the future deep-space communications and Space Information Networks (SIN, which are viewed as a primary solution to satisfy the increasing demands for high data rate services. However, Ka-band channel is much more sensitive to the weather conditions than the conventional communication channels. Moreover, due to the huge distance and long propagation delay in SINs, the transmitter can only obtain delayed Channel State Information (CSI from feedback. In this paper, the noise temperature of time-varying rain attenuation at Ka-band channels is modeled to a two-state Gilbert–Elliot channel, to capture the channel capacity that randomly ranging from good to bad state. An optimal transmission scheme based on Partially Observable Markov Decision Processes (POMDP is proposed, and the key thresholds for selecting the optimal transmission method in the SIN communications are derived. Simulation results show that our proposed scheme can effectively improve the throughput.

Calculation of the total plasma concentration of nonvolatile weak acids and the effective dissociation constant of nonvolatile buffers in plasma for use in the strong ion approach to acid-base balance in cats.

Science.gov (United States)

McCullough, Sheila M; Constable, Peter D

2003-08-01

To determine values for the total concentration of nonvolatile weak acids (Atot) and effective dissociation constant of nonvolatile weak acids (Ka) in plasma of cats. Convenience plasma samples of 5 male and 5 female healthy adult cats. Cats were sedated, and 20 mL of blood was obtained from the jugular vein. Plasma was tonometered at 37 degrees C to systematically vary PCO2 from 8 to 156 mm Hg, thereby altering plasma pH from 6.90 to 7.97. Plasma pH, PCO2, and concentrations of quantitatively important strong cations (Na+, K+, and Ca2+), strong anions (Cl-, lactate), and buffer ions (total protein, albumin, and phosphate) were determined. Strong ion difference was estimated from the measured strong ion concentrations and nonlinear regression used to calculate Atot and Ka from the measured pH and PCO2 and estimated strong ion difference. Mean (+/- SD) values were as follows: Atot = 24.3 +/- 4.6 mmol/L (equivalent to 0.35 mmol/g of protein or 0.76 mmol/g of albumin); Ka = 0.67 +/- 0.40 x 10(-7); and the negative logarithm (base 10) of Ka (pKa) = 7.17. At 37 degrees C, pH of 7.35, and a partial pressure of CO2 (PCO2) of 30 mm Hg, the calculated venous strong ion difference was 30 mEq/L. These results indicate that at a plasma pH of 7.35, a 1 mEq/L decrease in strong ion difference will decrease pH by 0.020, a 1 mm Hg decrease in PCO2 will increase plasma pH by 0.011, and a 1 g/dL decrease in albumin concentration will increase plasma pH by 0.093.

Inflation with a smooth constant-roll to constant-roll era transition

Science.gov (United States)

Odintsov, S. D.; Oikonomou, V. K.

2017-07-01

In this paper, we study canonical scalar field models, with a varying second slow-roll parameter, that allow transitions between constant-roll eras. In the models with two constant-roll eras, it is possible to avoid fine-tunings in the initial conditions of the scalar field. We mainly focus on the stability of the resulting solutions, and we also investigate if these solutions are attractors of the cosmological system. We shall calculate the resulting scalar potential and, by using a numerical approach, we examine the stability and attractor properties of the solutions. As we show, the first constant-roll era is dynamically unstable towards linear perturbations, and the cosmological system is driven by the attractor solution to the final constant-roll era. As we demonstrate, it is possible to have a nearly scale-invariant power spectrum of primordial curvature perturbations in some cases; however, this is strongly model dependent and depends on the rate of the final constant-roll era. Finally, we present, in brief, the essential features of a model that allows oscillations between constant-roll eras.

Tri- and tetra-substituted cyclen based lanthanide(III) ion complexes as ribonuclease mimics: a study into the effect of log Ka, hydration and hydrophobicity on phosphodiester hydrolysis of the RNA-model 2-hydroxypropyl-4-nitrophenyl phosphate (HPNP).

Science.gov (United States)

Fanning, Ann-Marie; Plush, Sally E; Gunnlaugsson, Thorfinnur

2015-05-28

A series of tetra-substituted 'pseudo' dipeptide ligands of cyclen (1,4,7,10,-tetraazacyclododecane) and a tri-substituted 3'-pyridine ligand of cyclen, and the corresponding lanthanide(III) complexes were synthesised and characterised as metallo-ribonuclease mimics. All complexes were shown to promote hydrolysis of the phosphodiester bond of 2-hydroxypropyl-4-nitrophenyl phosphate (HPNP, τ1/2 = 5.87 × 10(3) h), a well known RNA mimic. The La(III) and Eu(III) tri-substituted 3'-pyridine lanthanide(III) complexes being the most efficient in promoting such hydrolysis at pH 7.4 and at 37 °C; with τ1/2 = 1.67 h for La(III) and 1.74 h for Eu(III). The series was developed to provide the opportunity to investigate the consequences of altering the lanthanide(III) ion, coordination ability and hydrophobicity of a metallo-cavity on the rate of hydrolysis using the model phosphodiester, HPNP, at 37 °C. To further provide information on the role that the log Ka of the metal bound water plays in phosphodiester hydrolysis the protonation constants and the metal ion stability constants of both a tri and tetra-substituted 3'pyridine complex were determined. Our results highlighted several key features for the design of lanthanide(III) ribonucelase mimics; the presence of two metal bound water molecules are vital for pH dependent rate constants for Eu(III) complexes, optimal pH activity approximating physiological pH (∼7.4) may be achieved if the log Ka values for both MLOH and ML(OH)2 species occur in this region, small changes to hydrophobicity within the metallo cavity influence the rate of hydrolysis greatly and an amide adjacent to the metal ion capable of forming hydrogen bonds with the substrate is required for achieving fast hydrolysis.

Fields of rational constants of cyclic factorizable derivations

Directory of Open Access Journals (Sweden)

Janusz Zielinski

2015-12-01

Full Text Available We describe all rational constants of a large family of four-variable cyclic factorizable derivations. Thus, we determine all rational first integrals of their corresponding systems of differential equations. Moreover, we give a characteristic of all four-variable Lotka-Volterra derivations with a nontrivial rational constant. All considerations are over an arbitrary field of characteristic zero. Our main tool is the investigation of the cofactors of strict Darboux polynomials. Factorizable derivations are important in derivation theory. Namely, we may associate the factorizable derivation with any given derivation of a polynomial ring and that construction helps to determine rational constants of arbitrary derivations. Besides, Lotka-Volterra systems play a significant role in population biology, laser physics and plasma physics.

Calculation of attenuation by rain using the DAH model and diameter of antennas for the Ka Band in Mexico; Calculo de atenuacion por lluvia usando el modelo DAH y diametro de antena para Banda Ka en Mexico

Energy Technology Data Exchange (ETDEWEB)

Landeros-Ayala, S.; Neri-Vela, R; Cruz-Sanchez, H.; Hernandez-Bautista, H. [Universidad Nacional Autonoma de Mexico, Mexico, D.F. (Mexico)

2002-03-01

In the last years, the peak in the demand of satellite communication service has caused the saturation in the use of the frequencies corresponding to the band, Cand Ku. Due to this, the engineers have looked for viable alternatives, in order to satisfy the current requisition, as well as the future demand, for which a considerable increment is expected. One of these alternatives is the use of the Ka Band (20Hz/30Hz), that is why the importance of studying the propagation effects that are experienced at these frequencies, especially the attenuation effect by rain, as in this case, where it is significant. The present article has the purpose to describe the use of the Modelo DAH (whose authors are Asoka Dissanayake, Jeremy Allnutt and Fatim Haidara), mixed with the global maps of distribution of rain by Crane, for the calculation of the attenuation by rain in satellite communication systems operated in the Ka Band. Besides, antenna diameters for the systems of communications in Ka Band in different locations of the Mexican Republic, using for it the attenuation margins for rain obtained through the Modelo DAH, and using as references the characteristics of the ANIK F2 satellite and a terrestrial station VSAT, are proposed. [Spanish] En los ultimos anos, el auge en la demanda de servicios de comunicacion por satelite ha provocado la saturacion en los uso de la frecuencia correspondientes a las bandas C y Ku. Debido a esta razon, se han buscado alternativas viables para poder satisfacer la demanda actual, asi como la demanda futura, para la cual se espera un incremento considerable. Una de estas alternativas es el uso de Banda Ka (20Hz/30Hz), de ahi la importancia del estudio sobre los efectos de programacion que se experimentan a esta frecuencia, en especial, el efecto de atencion por lluvias, ya que sen este caso resulta ser significativa. El presente articulo tiene como finalidad describir el uso del Modelo DAH (cuyos autores son Asoka Dissanayake, Jeremy Allnutt y

Różnicowanie infekcyjnego zapalenia krążka międzykręgowego i seronegatywnej spondyloartropatii

Directory of Open Access Journals (Sweden)

Maria Maślińska

2011-06-01

Full Text Available Objawy infekcyjnego zapalenia krążka międzykręgowego mogąimitować objawy spondyloartropatii seronegatywnych i wymagaćróżnicowania wśród tych jednostek chorobowych (tab. I. Spondyloartropatieseronegatywne to grupa zapalnych chorób przebiegającychz zajęciem stawów kręgosłupa i stawów obwodowych.Wśród zapaleń kości i szpiku infekcyjne zapalenie krążka międzykręgowegostanowi ok. 2–4% wszystkich przypadków. Poniżejprzedstawiono opis przypadku 18-letniego mężczyzny diagnozowanegoz powodu podejrzenia spondyloartropatii. U pacjentawystępowały: ból kręgosłupa o charakterze zapalnym, bóle stawówobwodowych oraz epizody stanów gorączkowych. Po wykluczeniuspondyloartropatii ostatecznie rozpoznano u pacjentainfekcyjne zapalenie krążka międzykręgowego. Dzięki diagnostycemetodą rezonansu magnetycznego możliwe było postawienie diag -nozy (ryc. 1, 2 oraz ocena skuteczności leczenia (ryc. 3, 4. Niew każdym przypadku infekcyjnego zapalenia krążka międzykręgowegomożliwe jest ustalenie czynnika etiologicznego, wówczasw leczeniu należy uwzględnić potencjalne czynniki ryzyka zakażeniaoraz najczęstsze patogeny, będące przyczyną spondylodiscitis,takie jak Staphylococcus aureus (w 50% przypadków i Escherichiacoli (23%. Brak klinicznej poprawy po 2 tygodniach optymalniecelowanej antybiotykoterapii drogą dożylną byłby wskazaniem doleczenia chirurgicznego.Womawianym przypadku rozpoznanie kliniczne potwierdził dobryefekt terapeutyczny prowadzonej antybiotykoterapii, wobec czegonie było wskazań do leczenia operacyjnego. Opisany przypadekwskazuje również na konieczność szybkiej oceny kręgosłupa pierwmetodąrezonansu magnetycznego u pacjentów z bólem zapalnymkręgosłupa i objawami ogólnymi wobec wątpliwości co do ich etiologiii braku wyjaśnienia ich przyczyny klasycznym zdjęciem radiologicznym.Ponieważ bardziej narażeni na infekcyjne zapaleniekrążka międzykręgowego są chorzy z obni

Transmission characteristic of graphene/TiO2 paper measured at Ka-band

Science.gov (United States)

Agusu, La; Mitsudo, Seitaro; Ahmad, La Ode; Herdianto, Fujii, Yutaka; Ishikawa, Yuya; Furuya, Takahashi; Ramadhan, La Ode Ahmad Nur

2017-01-01

The commercial telecommunication system in future would explore the electromagnetic spectrum with higher frequency than used now, because it requires higher speed of transmission data. Using the millimeter waves (mmW) with frequency ranging from 30 to 300 GHz, such requirement could be fulfilled. The upcoming 5G cellular technology is expected to use frequency 30 GHz or higher. Then materials with a specific characteristic at the mmW range are interesting to be explored and investigated. Here, we report the synthesis process of graphene/TiO2 deposited on paper and their transmission characteristics to the electromagnetic energy at frequency 27-40 GHz (Ka-Band). The reduced graphene oxide (rGO) was synthesized by a modified Hummers method with introduction of microwave irradiation in the process. rGO and TiO2 were mixed in ethanol solution and deposited on the paper by a spraying technique. Transmission coefficient of electromagnetic wave energy at Ka-Band was measured by using the millimeter vector network analyzer. Conductivity of rGO is 1.89 Scm-1 and for the graphene/TiO2 with TiO2 content is up to 50%, conductivity is down to Scm-1 Graphene/TiO2 layer with thickness of 60).lm and TiO2 loading up to 25% can has the transmission coefficient of -4 dB at the middle frequency of 31 GHz and bandwidth of 2.2 GHz. This can be useful as the electromagnetic interference shielding material at Ka-band.

Kas Roger Federer suudab Rafael Nadali alistada ka Pariisis? / Maarja Värv

Index Scriptorium Estoniae

Värv, Maarja

2007-01-01

Prantsusmaa lahtiste tennisemeistrivõistluste eel on paljude jaoks suurim küsimus, kas maailma esinumber Roger Federer suudab lõpuks võita ka Roland Garros' esikoha ning astuda sammu suure slämmi suunas. Vt. samas: Maret Ani põhiturniirile ei pääsenud

From the Rydberg constant to the fundamental constants metrology; De la constante de Rydberg a la metrologie des constantes fondamentales

Energy Technology Data Exchange (ETDEWEB)

Nez, F

2005-06-15

This document reviews the theoretical and experimental achievements of the author since the beginning of his scientific career. This document is dedicated to the spectroscopy of hydrogen, deuterium and helium atoms. The first part is divided into 6 sub-sections: 1) the principles of hydrogen spectroscopy, 2) the measurement of the 2S-nS/nD transitions, 3) other optical frequency measurements, 4) our contribution to the determination of the Rydberg constant, 5) our current experiment on the 1S-3S transition, 6) the spectroscopy of the muonic hydrogen. Our experiments have improved the accuracy of the Rydberg Constant by a factor 25 in 15 years and we have achieved the first absolute optical frequency measurement of a transition in hydrogen. The second part is dedicated to the measurement of the fine structure constant and the last part deals with helium spectroscopy and the search for optical references in the near infrared range. (A.C.)

Riik plaanib haiglatele anda õiguse ka arstirohtu müüa / Andrus Karnau

Index Scriptorium Estoniae

Karnau, Andrus

2006-01-01

Vt. ka Postimees : na russkom jazõke 31. märts lk. 3. Riik tahab anda haiglatele õiguse pidada jaemüügirohupoode, selle kava vastu on aga konkureerivad apteegiketid, konkurentsi- ja ravimiamet. Lisa: Ketistunud apteegiturg

Deriving and Interpreting Ka(karimusubi in Premodern Japanese

Directory of Open Access Journals (Sweden)

Moreno MITROVIĆ

2015-02-01

Full Text Available This paper provides a new syntax and semantics for kakarimusubi (KM, a focus construction prominent in the grammar of Old Japanese (OJ and Early Middle (Classical Japanese (CJ, which diachronically developed into the interrogative construction in Modern Japanese (MdJ headed by the ka particle. Adopting Chierchia & Caponigro’s (2013 novel analysis of Free Relatives (FRs as embedded interrogatives, an FR-based analysis of KM is proposed so as to obtain a compositional semantic analysis of this focus construction as well as an account of the adnominal marking of the presuppositional musubi component of this grammatical construction.

FIZIČKA AKTIVNOST I ŠEĆERNA BOLEST

OpenAIRE

BARETIĆ, MAJA

2017-01-01

Sve veća učestalost šećerne bolesti povezuje se s prihvaćanjem netradicionalnih načina prehrane i prakticiranjem „sjedilačkog načina života“. Liječenje šećerne bolesti sastoji se od promjene životnog stila što uključuje promjenu fizičke aktivnosti, tipa i učestalosti prehrane te uzimanje specifi čne terapije. Fizička aktivnost je dio temeljnog liječenja dijabetesa; ima dokazane koristi u smanjenju inzulinske rezistencije, poboljšanju glikemijske kontrole, lipidnog profi la, u normalizaciji tj...

Test results of a 20 kA high temperature superconductor current lead using REBCO tapes

Science.gov (United States)

Heller, R.; Fietz, W. H.; Gröner, F.; Heiduk, M.; Hollik, M.; Lange, C.; Lietzow, R.

2018-05-01

The Karlsruhe Institute of Technology has developed a 20 kA high temperature superconductor (HTS) current lead (CL) using the second generation material REBCO, as industry worldwide concentrate on the production of this material. The aim was to demonstrate the possibility of replacing the Bi-2223/AgAu tapes by REBCO tapes, while for easy comparison of results, all other components are copies of the 20 kA HTS CL manufactured for the satellite tokamak JT-60SA. After the manufacture of all CL components including the newly developed REBCO module, the assembly of the CL has been executed at KIT and an experiment has been carried out in the CuLTKa test facility where the REBCO CL was installed and connected to a JT-60SA CL via a superconducting bus bar. The experiment covers steady state operation up to 20 kA, pulsed operation, measurement of the heat load at 4.5 K end, loss-of-flow-accident simulations, and quench performance studies. Here the results of these tests are reported and directly compared to those of the JT-60SA CL.

A 230 ka record of glacial and interglacial events from Aurora Cave, Fiordland, New Zealand

International Nuclear Information System (INIS)

Williams, P.W.

1996-01-01

Caves overrun by glaciers are known to accumulate dateable evidence of past glacial and interglacial events. Results are reported from an investigation of Aurora Cave on the slopes above Lake Te Anau in Fiordland. The cave commenced to form before c. 230 ka B.P. Sequences of glaciofluvial sediments interbedded with speleothems are evidence of the number and timing of glacial advances and the status of intervals between them. Twenty-six uranium series dates on speleothems underpin a chronology of seven glacial advances in the last 230 ka, with the peak of the late Otira glaciation, Aurora 3 advance, at c. 19 ka B.P. With five advances in the Otiran, the last glaciation is more complex than previously recognised. Comparison of the record with that recorded offshore from DSDP Site 594 reveals little matching, but the correspondence of the Aurora sequence with that interpreted from other onshore deposits is more convincing. Glacial deposits on slopes above the cave for a further 660 m may be evidence of the 'missing' glacial events of the mid-early Pleistocene. (author). 44 refs., 12 figs., 5 tabs

Solid State KA-Band, Solid State W-Band and TWT Amplifiers, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Phase I of the proposal describes plans to develop a state of the art transmitter for the W-Band and KA -Band Cloud Radar system. Our focus will be concentrated in...

Investigation of the adsorption of water vapor and carbon dioxide by KA zeolite

International Nuclear Information System (INIS)

Khanitonov, V.P.; Shtein, A.S.

1984-01-01

According to the present data, KA zeolite, which can adsorb only water vapor, helium, and hydrogen, has the greatest selectivity in drying. The feasibility of using this zeolite in devices for selective drying of gases used in gas-analysis systems was studied. The results of the experiments were approximated by the thermal equation of the theory of bulk filling of micropores. The limiting value of the adsorption depends on the temperature, and it can be calculated according to the density of the adsorbed phase and the adsorption volume. The critical diameters of the water and carbon dioxide molecules are close to the dimensions of the KA-zeolite pores, something that determines the activated nature of the adsorption of these substances. Experiments on coadsorption of water vapor and carbon dioxide by a fixed bed of KA-zeolite under dynamic conditions showed that the adsorption of these substances has a frontal nature. The time of the protective action of the layer of zeolite during adsorption af water vapor exceeded by more than an order the time of the protective action during adsorption of carbon dioxide. The results showed that this adsorbent can be used for selective drying of gas mixtures containing carbon dioxide in batch-operation devices. Beforehand, the adsorbent should be regenerated with respect to moisture, and then it should be saturated with carbon dioxide by blowing the adsorbent with a gas mixture of the working composition until the equilibrium state is reached

Consolidation of the 13 kA Interconnects in the LHC for Operation at 7 TeV

CERN Document Server

Verweij, A P; Tock, J P; Willering, G P; Steckert, J; Perin, A; Scheuerlein, C; Mathot, S; Koratzinos, M; Garion, C; Denz, R; Fessia, P; Charifoulline, Z; Bertinelli, F; Sgobba, S; ten Kate, H H J

2011-01-01

The accident in the LHC in September 2008 occurred in an interconnection between two magnets of the 13 kA dipole circuit. Successive measurements of the resistance of other interconnects revealed other defective joints, even though the SC cables were properly connected. These defective joints are characterized by a poor bonding between the SC cable and the copper stabilizer in combination with an electrical discontinuity in the copper stabilizer. A quench at the 7-13 kA level in such a joint can lead to a fast and unprotected thermal run-away and hence opening of the circuit. It has therefore been decided to operate the LHC at a reduced and safe current of 6 kA corresponding to 3.5 TeV beam energy until all defective joints are repaired. A task force is reviewing the status of all electrical joints in the magnet circuits and preparing for the necessary repairs. The principle solution is to resolder the worst defective joints and, in addition, to apply an electrical shunt made of copper across all joints with ...

Expansion of plasma of electrically exploding single copper wire under 4.5 kA-9.5 kA/wire

International Nuclear Information System (INIS)

Li Yexun; Yang Libing; Sun Chengwei

2003-01-01

The experimental system for electrically exploding single metal wire has been designed and manufactured. Expansion of the dense plasma column formed from an electrically exploding Cu wire of diameter 30 μm has been studied with a high-speed photographer to obtain the time-dependent radius (R-t) curve. The experimental results demonstrate that the mean expansion rate of the dense plasma column is 1.94 μm/ns, 2.6 μm/ns and 3.75 μm/ns according to the peak pulse current 4.5 kA, 7 kA and 9.5 kA respectively. The results can be beneficial to giving a profound understanding of the early stage of wire-array Z-pinch physics and to improvement on their design

The Small Mammal Sequence from the c. 76 - 72 ka Still Bay Levels at Blombos Cave, South Africa - Taphonomic and Palaeoecological Implications for Human Behaviour.

Directory of Open Access Journals (Sweden)

Turid Hillestad Nel

Full Text Available The Still Bay, c. 76-72 ka, a prominent techno-tradition during the Middle Stone Age of southern Africa, has yielded innovative technologies, symbolic material culture, and shows evidence of expansion of hunting techniques and subsistence strategies. In this paper we present the results of the first systematic, taphonomic and palaeoenvironmental study of micromammals from the Still Bay levels at Blombos Cave. Our taphonomic analysis indicates that the micromammals were accumulated by avian predators occupying the cave. Post-depositional processes affecting the micromammal assemblage include organic waste decomposition and conditions associated with a limestone cave environment. The palaeoenvironmental reconstruction shows that Marine Isotope Stage (MIS 5a at Blombos Cave had diverse micromammal communities occupying a variety of habitats and with rainfall pattern equal to present. The transition from MIS 5a to 4 is indicated by less diverse micromammal assemblages, increase in grassland and scrub vegetation, shifts in seasonal precipitation, and a decline in shrubs associated with fynbos. The onset of the glacial conditions associated with MIS 4 is visible in the micromammal assemblage. However humans occupying Blombos Cave during this c. 5 ka period showed an ability to cope with changing environmental conditions and were able to adapt and utilise a variety of available resources.

The Small Mammal Sequence from the c. 76 - 72 ka Still Bay Levels at Blombos Cave, South Africa - Taphonomic and Palaeoecological Implications for Human Behaviour.

Science.gov (United States)

Nel, Turid Hillestad; Henshilwood, Christopher Stuart

2016-01-01

The Still Bay, c. 76-72 ka, a prominent techno-tradition during the Middle Stone Age of southern Africa, has yielded innovative technologies, symbolic material culture, and shows evidence of expansion of hunting techniques and subsistence strategies. In this paper we present the results of the first systematic, taphonomic and palaeoenvironmental study of micromammals from the Still Bay levels at Blombos Cave. Our taphonomic analysis indicates that the micromammals were accumulated by avian predators occupying the cave. Post-depositional processes affecting the micromammal assemblage include organic waste decomposition and conditions associated with a limestone cave environment. The palaeoenvironmental reconstruction shows that Marine Isotope Stage (MIS) 5a at Blombos Cave had diverse micromammal communities occupying a variety of habitats and with rainfall pattern equal to present. The transition from MIS 5a to 4 is indicated by less diverse micromammal assemblages, increase in grassland and scrub vegetation, shifts in seasonal precipitation, and a decline in shrubs associated with fynbos. The onset of the glacial conditions associated with MIS 4 is visible in the micromammal assemblage. However humans occupying Blombos Cave during this c. 5 ka period showed an ability to cope with changing environmental conditions and were able to adapt and utilise a variety of available resources.

Prediction Of pKa From Chemical Structure Using Free And Open-Source Tools

Science.gov (United States)

The ionization state of a chemical, reflected in pKa values, affects lipophilicity, solubility, protein binding and the ability of a chemical to cross the plasma membrane. These properties govern the pharmacokinetic parameters such as absorption, distribution, metabolism, excreti...

High-Efficiency, Ka-band Solid-State Power Amplifier Utilizing GaN Technology, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — QuinStar Technology proposes to develop an efficient, solid-state power amplifier (SSPA), operating at Ka-band frequencies, for high data rate, long range space...

Liha tootmine : [2000-2004 Eestis liikide kaupa, s.h. ka kitseliha] / Matti Piirsalu

Index Scriptorium Estoniae

Piirsalu, Matti, 1947-

2005-01-01

Ilmunud ka: Agriculture and the development of rural life : overview 2004/2005. - Tallinn, 2005, lk. 20-22. 2004. a. vähenes sealihatoodang 3%, lamba- ja kitseliha toodang 25%.Veise- ja linnuliha tootmine kasvas kubki 5%. Tabel: Lihatoodang aastatel 2000-2004

High-Efficiency, Ka-Band Solid-State Power Amplifier Utilizing GaN Technology, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — QuinStar Technology proposes to develop a high-efficiency, solid-state power amplifier (SSPA), operating at Ka-band frequencies, for high data rate, long range space...

Ion exchange equilibrium constants

CERN Document Server

Marcus, Y

2013-01-01

Ion Exchange Equilibrium Constants focuses on the test-compilation of equilibrium constants for ion exchange reactions. The book first underscores the scope of the compilation, equilibrium constants, symbols used, and arrangement of the table. The manuscript then presents the table of equilibrium constants, including polystyrene sulfonate cation exchanger, polyacrylate cation exchanger, polymethacrylate cation exchanger, polysterene phosphate cation exchanger, and zirconium phosphate cation exchanger. The text highlights zirconium oxide anion exchanger, zeolite type 13Y cation exchanger, and

Efficient Aerobic Oxidation of Cyclohexane to KA Oil Catalyzed by Pt ...

Indian Academy of Sciences (India)

127, No. 7, July 2015, pp. 1167–1172. c Indian Academy of Sciences. ... The catalyst was used for the partial oxidation of cyclohexane in a Parr type reactor. It was found that Pt-Sn supported on MWCNTs can act as an efficient catalyst for the partial ... version ratio with high selectivity for KA oil in a liquid ... These gases.

Enroni krahh võib hakata mõjutama ka Eesti ettevõtteid / Gert D. Hankewitz

Index Scriptorium Estoniae

Hankewitz, Gert D.

2006-01-01

USA energiafirma Enron finantspettus võib hakata läbi koostööpartnerite, kellele hakkavad kehtima karmimad raamatupidamisreeglid, mõjutama ka Eesti firmasid. Vt. samas: Akt karmistab reegleid; Hansapangale tooks akt lisakulutusi

Evidence of Gate Voltage Oscillations during Short Circuit of Commercial 1.7 kV/ 1 kA IGBT Power Modules

DEFF Research Database (Denmark)

Reigosa, Paula Diaz; Wu, Rui; Iannuzzo, Francesco

2015-01-01

This paper analyzes the evidence of critical gate voltage oscillations in 1.7 kV/1 kA Insulated-Gate Bipolar Transistor (IGBT) power modules under short circuit conditions. A 6 kA/1.1 kV Non-Destructive Test (NDT) set up for repeatable short circuit tests has been built with a 40 nH stray inducta...

Round busbar concept for 30 nH, 1.7 kV, 10 kA IGBT non-destructive short-circuit tester

DEFF Research Database (Denmark)

Smirnova, Liudmila; Pyrhönen, Juha; Iannuzzo, Francesco

2014-01-01

Design of a Non-Destructive Test (NDT) set-up for short-circuit tests of 1.7 kV, 1 kA IGBT modules is discussed in this paper. The test set-up allows achieving short-circuit current up to 10 kA. The important objective during the design of the test set-up is to minimize the parasitic inductance...

Metal Deposition Along the Peru Margin Since the Last Glacial Maximum: Evidence For Regime Change at \\sim 6ka

Science.gov (United States)

Tierney, J.; Cleaveland, L.; Herbert, T.; Altabet, M.

2004-12-01

The Peru Margin upwelling zone plays a key role in regulating marine biogeochemical cycles, particularly the fate of nitrate. High biological productivity and low oxygen waters fed into the oxygen minimum zone result in intense denitrification in the modern system, the consequences of which are global in nature. It has been very difficult, however, to study the paleoclimatic history of this region because of the poor preservation of carbonate in Peru Margin sediments. Here we present records of trace metal accumulation from two cores located in the heart of the suboxic zone off the central Peru coast. Chronology comes from multiple AMS 14C dates on the alkenone fraction of the sediment, as well as correlation using major features of the \\delta 15N record in each core. ODP Site 1228 provides a high resolution, continuous sediment record from the Recent to about 14ka, while gravity core W7706-41k extends the record to the Last Glacial Maximum. Both cores were sampled at a 100 yr resolution, then analyzed for % N, \\delta 15N, alkenones, and trace metal concentration. Analysis of redox-sensitive metals (Mo and V) alongside metals associated with changes in productivity (Ni and Zn) provides perspective on the evolution of the upwelling system and distinguishes the two major factors controlling the intensity of the oxygen minimum zone. The trace metal record exhibits a notable increase in the intensity and variability of low oxygen waters and productivity beginning around 6ka and extending to the present. Within this most recent 6ka interval, the data suggest fluctuations in oxygenation and productivity occur on 1000 yr timescales. Our core records, therefore, suggest that the Peru Margin upwelling system strengthened significantly during the mid to late Holocene.

Statistical orientation fluctuations: constant angular momentum versus constant rotational frequency constraints

Energy Technology Data Exchange (ETDEWEB)

Goodman, A L [Tulane Univ., New Orleans, LA (United States)

1992-08-01

Statistical orientation fluctuations are calculated with two alternative assumptions: the rotational frequency remains constant as the shape orientation fluctuates; and, the average angular momentum remains constant as the shape orientation fluctuates. (author). 2 refs., 3 figs.

Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures

DEFF Research Database (Denmark)

Kristensen, Bjarne Winther; Noraberg, J; Zimmer, J

2001-01-01

) values was found after 2 days of exposure: AMPA (3.7 mM)>NMDA (11 mM)=KA (13 mM)>ATPA (33 mM). Exposed to 30 microM ATPA, 3 microM AMPA and 10 microM NMDA, CA1 was the most susceptible subfield followed by fascia dentata and CA3. Using 8 microM KA, CA3 was the most susceptible subfield, followed...... by fascia dentata and CA1. In 100 microM concentrations, all four agonists induced the same, maximal PI uptake in all hippocampal subfields, corresponding to total neuronal degeneration. Using glutamate receptor antagonists, like GYKI 52466, NBQX and MK-801, inhibition data revealed that AMPA excitotoxicity...

Multiple scattering effects on the Linear Depolarization Ratio (LDR) measured during CaPE by a Ka-band air-borne radar

Science.gov (United States)

Iguchi, Toshio; Meneghini, Robert

1993-01-01

Air-borne radar measurements of thunderstorms were made as part of the CaPE (Convection and Precipitation/Electrification) experiment in Florida in July 1991. The radar has two channels, X-band (10 GHz) and Ka-band (34.5 GHz), and is capable of measuring cross-polarized returns as well as co-polarized returns. In stratiform rain, the cross-polarized components can be observed only at the bright band region and from the surface reflection. The linear depolarization ratios (LDR's) measured at X-band and Ka-band at the bright band are nearly equal. In convective rain, however, the LDR in Ka-band often exceeds the X-band LDR by several dB, and sometimes by more than 10 dB, reaching LDR values of up to -5 dB over heavy convective rain. For randomly oriented hydrometeors, such high LDR values cannot be explained by single scattering from non-spherical scattering particles alone. Because the LDR by single backscatter depends weakly on the wavelength, the difference between the Ka-band and X-band LDR's suggests that multiple scattering effects prevail in the Ka-band LDR. In order to test this inference, the magnitude of the cross-polarized component created by double scattering was calculated using the parameters of the airborne radar, which for both frequencies has beamwidths of 5.1 degrees and pulse widths of 0.5 microsecond. Uniform rain beyond the range of 3 km is assumed.

Simultaneous high-throughput determination of interaction kinetics for drugs and cyclodextrins by high performance affinity chromatography with mass spectrometry detection.

Science.gov (United States)

Wang, Caifen; Wang, Xiaobo; Xu, Xiaonan; Liu, Botao; Xu, Xu; Sun, Lixin; Li, Haiyan; Zhang, Jiwen

2016-02-25

The individual determination of the apparent dissociation rate constant (kd,app) using high performance affinity chromatography (HPAC) is a tedious process requiring numerous separate tests and massive data fitting, unable to provide the apparent association rate constant (ka) and equilibrium binding constant (Ka). In this study, a HPAC with mass spectrometry detection (HPAC-MS/MS) was employed to determine the drug-cyclodextrin (CD) interaction kinetics with low sample loading quantity (drugs determined in one injection. The kd,app measured by HPAC-MS/MS approach were 0.89 ± 0.07, 4.34 ± 0.01, 1.48 ± 0.01 and 7.77 ± 0.04 s(-1) for ketoprofen, trimethoprim, indapamide and acetaminophen, with kd,app for acetaminophen consistent with that from the HPAC method with UV detector in our previous studies. For twenty drugs with diverse structures and chemical properties, good correlationship was found between kd,app measured by single compound analysis method and high-throughput HPAC-MS/MS approach, with the correlation coefficient of 0.987 and the significance F less than 0.001. Comprehensive quantification of ka,app, kd,app and Ka values was further performed based on the measurement of kd,app by peak profiling method and Ka by the peak fitting method. And the investigation of the drug-CD interaction kinetics under different conditions indicated that the column temperature and mobile phase composition significantly affected the determination of ka,app, kd,app and Ka while also dependent on the acidity and basicity of drugs. In summary, the high-throughput HPAC-MS/MS approach has been demonstrated high efficiency in determination of the drug-CD primary interaction kinetic parameter, especially, kd,app, being proven as a novel tool in screening the right CD for the solubilization of the right drug. Copyright © 2016 Elsevier B.V. All rights reserved.

MARKETINŠKA STRATEGIJA ZA SPLETNO TRGOVINO KUPONI.ENAA.COM

OpenAIRE

Marzidošek, Dean

2016-01-01

Marketinška strategija za spletne trgovine je precej drugačna od klasične marketinške strategije. Seveda upošteva enake zakonitosti, vendar so v večini primerov klasični oglaševalski kanali, kot so na primer televizija, radio, tisk in podobno, popolnoma odsotni. Na drugi strani jih nadomeščajo digitalni kanali v popolnosti, ki se jim je treba tudi bolj podrobno posvetiti v spletni strategiji. Prednost digitalnih kanalov je v zelo dobri in hitri merljivosti rezultatov, dostopnost takšnih oglaš...

Weathering rind formation in buried terrace cobbles during periods of up to 300ka

International Nuclear Information System (INIS)

Yoshida, H.; Metcalfe, R.; Nishimoto, S.; Yamamoto, H.; Katsuta, N.

2011-01-01

Highlights: → Weathering rinds in sandstone and basalt cobbles buried for up to 300 ka have been investigated. → The aim was to determine the formation process and elemental mass balances during rind development. → Elemental mass balances across the rinds were determined by using open system mass balance (τ i,j ) calculations. → The formation rates are slower than the tropical areas due to the lower rainfall in the studied area. - Abstract: Weathering rinds formed in Mesozoic sandstone and basalt cobbles buried in terrace deposits for up to 300 ka have been investigated. The aim was to determine the formation process and elemental mass balances during rind development. The ages of terraces distributed in the western part of Fukui prefecture, central Japan have been determined as 50 ka, 120 ka and 300 ka based on a tephro-stratigraphic method. Detailed investigations across the weathering rinds, consisting of microscopic observations, porosity measurements, and mineralogical and geochemical analyses using X-ray diffractometry (XRD), X-ray fluorescence (XRF), secondary X-ray analytical microscopy (SXAM), scanning electron microanalyser (SEM) and electron probe microanalysis (EPMA) have been carried out. The results revealed that the Fe concentrations in the weathering rind of a basalt cobble slightly decreased from the cobble's surface (rim) towards the unweathered core. In contrast, in a sandstone cobble formed under the same environmental conditions over the same period of time there is an Fe-rich layer at some distance below the cobble's surface. Elemental mass balances across the rinds were determined by using open system mass balance (τ i,j ) calculations and show that the Fe was precipitated as Fe-oxyhydroxides in the basalt cobbles, although Fe was slightly removed from the rims. In sandstone cobbles, on the other hand, Fe migrated along a Fe concentration gradient by diffusion and precipitated as Fe-oxyhydroxide minerals to form the weathering rinds

Development and performance test results of 50 kA vapor-cooled current lead for ITER

International Nuclear Information System (INIS)

Sugimoto, Makoto; Isono, Takaaki; Hamada, Kazuya

1998-01-01

JAERI has developed 50 kA current leads for the International Thermonuclear Experimental Reactor (ITER). The Center Solenoid (CS) Model Coil program is under way by means of international collaboration in ITER-EDA. The CS model coil is being developed for ITER CS coil and is for demonstration for ITER construction. The performance test of the CS model coil will be carried out at the JAERI ITER common test facility (CTF). The current lead consists of the vertical lead and the connection lead. The vertical lead is a vapor-cooled type and has a cable-in-conduit geometry. The vertical lead was designed with a heat leak of 1.2 W/kA at a helium flow rate of 0.06 g/(s·kA). The measured heat leak satisfied the designed value. The connection lead was made from copper pipe soldered with NbTi superconducting wires. The pipe was stabilized by the superconducting wires and a cooling channel. The current lead was operated up to 60 kA. The design and the performance test results of 50 kA current leads are reported. The results meet the specifications for the CS model coil test and for the ITER real machine. (author)

Response of benthic foraminifera to 4.2 ka cooling event in the Nakdong River delta, southeast Korea

Science.gov (United States)

Takata, H.; Khim, B. K.; Cheong, D.; Shin, S.

2016-02-01

Here we report the change of benthic foraminifera in response to 4.2 ka cooling event in the Nakdong River delta (southeastern Korea). It has been known that this cooling event caused climatic deteriorations in the world, which is closely related to the decline/development of the civilizations (e.g., Kawahata et al., 2009). This event was also correlated to one of Bond Events in the North Atlantic. Because coastal sediment depositions have been influenced by both oceanographic and terrestrial climatic changes, the study may provide us clue to understand the possible teleconnection of the cooling event between the North Atlantic and the East Asian margin. We investigated fossil benthic foraminiferal faunas and planktonic/total foraminiferal ratio (P/T ratio) at two borehole cores, ND-01 and ND-02 (landward and seaward sites, respectively). Common constituents are taxa from bay to shelf environments in the East Asian margin. Biotic response of benthic foraminifera partly changed after 4.2 ka showing that Haynesina sp. A (opportunistic species?) decreased significantly at core ND-01. In addition, P/T ratio at both core sites showed temporal decline at 4.2 ka. This suggests the decreasing influence of the seawater relative to the coastal water. Holocene fluctuations of the Tsushima Warm Current, a branch of Kuroshio, flowing off the Nakdong River delta, have been documented. The decline pattern of P/T ratio in this area is similar to that of total sulfur content in Lake Tougou-ike, southwestern Japan at 4 ka which was interpreted as the influence of the small sea-level falling (Kato et al., 2003). According to the similar stratigraphic variation patterns between our and their studies, our finding suggests that this event was not regional but related to the fluctuations of the Tsushima Warm Current. Thus, biotic response of benthic foraminifera in the Nakdong River delta recorded 4.2 ka cooling event related to temporal weakening of the Tsushima Warm Current.

The effects of multiple features of alternatively spliced exons on the KA/KS ratio test

Directory of Open Access Journals (Sweden)

Chen Feng-Chi

2006-05-01

Full Text Available Abstract Background The evolution of alternatively spliced exons (ASEs is of primary interest because these exons are suggested to be a major source of functional diversity of proteins. Many exon features have been suggested to affect the evolution of ASEs. However, previous studies have relied on the KA/KS ratio test without taking into consideration information sufficiency (i.e., exon length > 75 bp, cross-species divergence > 5% of the studied exons, leading to potentially biased interpretations. Furthermore, which exon feature dominates the results of the KA/KS ratio test and whether multiple exon features have additive effects have remained unexplored. Results In this study, we collect two different datasets for analysis – the ASE dataset (which includes lineage-specific ASEs and conserved ASEs and the ACE dataset (which includes only conserved ASEs. We first show that information sufficiency can significantly affect the interpretation of relationship between exons features and the KA/KS ratio test results. After discarding exons with insufficient information, we use a Boolean method to analyze the relationship between test results and four exon features (namely length, protein domain overlapping, inclusion level, and exonic splicing enhancer (ESE frequency for the ASE dataset. We demonstrate that length and protein domain overlapping are dominant factors, and they have similar impacts on test results of ASEs. In addition, despite the weak impacts of inclusion level and ESE motif frequency when considered individually, combination of these two factors still have minor additive effects on test results. However, the ACE dataset shows a slightly different result in that inclusion level has a marginally significant effect on test results. Lineage-specific ASEs may have contributed to the difference. Overall, in both ASEs and ACEs, protein domain overlapping is the most dominant exon feature while ESE frequency is the weakest one in affecting

Quantum Chemical Benchmarking, Validation, and Prediction of Acidity Constants for Substituted Pyridinium Ions and Pyridinyl Radicals.

Science.gov (United States)

Keith, John A; Carter, Emily A

2012-09-11

Sensibly modeling (photo)electrocatalytic reactions involving proton and electron transfer with computational quantum chemistry requires accurate descriptions of protonated, deprotonated, and radical species in solution. Procedures to do this are generally nontrivial, especially in cases that involve radical anions that are unstable in the gas phase. Recently, pyridinium and the corresponding reduced neutral radical have been postulated as key catalysts in the reduction of CO2 to methanol. To assess practical methodologies to describe the acid/base chemistry of these species, we employed density functional theory (DFT) in tandem with implicit solvation models to calculate acidity constants for 22 substituted pyridinium cations and their corresponding pyridinyl radicals in water solvent. We first benchmarked our calculations against experimental pyridinium deprotonation energies in both gas and aqueous phases. DFT with hybrid exchange-correlation functionals provide chemical accuracy for gas-phase data and allow absolute prediction of experimental pKas with unsigned errors under 1 pKa unit. The accuracy of this economical pKa calculation approach was further verified by benchmarking against highly accurate (but very expensive) CCSD(T)-F12 calculations. We compare the relative importance and sensitivity of these energies to selection of solvation model, solvation energy definitions, implicit solvation cavity definition, basis sets, electron densities, model geometries, and mixed implicit/explicit models. After determining the most accurate model to reproduce experimentally-known pKas from first principles, we apply the same approach to predict pKas for radical pyridinyl species that have been proposed relevant under electrochemical conditions. This work provides considerable insight into the pitfalls using continuum solvation models, particularly when used for radical species.

Decay constants of subcritical system by diffusion theory for two groups

International Nuclear Information System (INIS)

Moura Neto, C. de.

1977-01-01

The effects of a neutronic pulse applied to a subcritical multiplicative medium are analysed on the basis of the diffusion theory for one and two groups. The decay constants of the system for various values of geometric buckling were determined from the experimental data. A natural uranium-light water lattice was pulsed employing a Texas Nuclear 9905 neutron generator. The least square method was employed in the data reduction procedures to determine the decay constants. The separation of the decay constants associated with thermal and epithermal fluxes is attempted through two groups formulation. (author)

Decay constants of a subcritical system by two-group diffusion theory

International Nuclear Information System (INIS)

Moura Neto, C. de.

1979-08-01

The effects of a neutronic pulse applied to a subcritical multiplicative medium are analyzed on the basis of the diffusion theory for one and two groups. The decay constants of the system were determined from the experimental data, for various values geometric buckling. A natural uranium light-water configuration was pulsed employing a Texas Nuclear 9905 neutron generator. The least square method was employed in the data reduction procedures to determine the decay constants. The separation of the decay constants associated with thermal and epithermal fluxes are verified through two groups formulation. (Author) [pt

NALPS: a precisely dated European climate record 120–60 ka

Directory of Open Access Journals (Sweden)

R. Boch

2011-11-01

Full Text Available Accurate and precise chronologies are essential in understanding the rapid and recurrent climate variations of the Last Glacial – known as Dansgaard-Oeschger (D-O events – found in the Greenland ice cores and other climate archives. The existing chronological uncertainties during the Last Glacial, however, are still large. Radiometric age data and stable isotopic signals from speleothems are promising to improve the absolute chronology. We present a record of several precisely dated stalagmites from caves located at the northern rim of the Alps (NALPS, a region that favours comparison with the climate in Greenland. The record covers most of the interval from 120 to 60 ka at an average temporal resolution of 2 to 22 yr and 2σ-age uncertainties of ca. 200 to 500 yr. The rapid and large oxygen isotope shifts of 1 to 4.5‰ occurred within decades to centuries and strongly mimic the Greenland D-O pattern. Compared to the updated Greenland ice-core timescale (GICC05modelext the NALPS record confirms the timing of rapid warming and cooling transitions between 118 and 106 ka, but suggests younger ages for D-O events between 106 and 60 ka. As an exception, the timing of the rapid transitions into and out of the stadial following GI 22 is earlier in NALPS than in the Greenland ice-core timescale. In addition, there is a discrepancy in the duration of this stadial between the ice-core and the stalagmite chronology (ca. 2900 vs. 3650 yr. The short-lived D-O events 18 and 18.1 are not recorded in NALPS, provoking questions with regard to the nature and the regional expression of these events. NALPS resolves recurrent short-lived climate changes within the cold Greenland stadial and warm interstadial successions, i.e. abrupt warming events preceding GI 21 and 23 (precursor-type events and at the end of GI 21 and 25 (rebound-type events, as well as intermittent cooling events during GI 22 and 24. Such superimposed events have not yet been documented

Dopingaine võib kätte saada ka vanaema retseptiga / Kristjan Port ; intervjueerinud Indrek Kuus

Index Scriptorium Estoniae

Port, Kristjan, 1960-

2011-01-01

Intervjuu Tallinna Ülikooli terviseteaduste ja spordi instituudi direktori, SA Eesti Antidoping nõukogu liikme Kristjan Pordiga, kes tõdeb, et profispordi kõrval on dopingainetega muret ka harrastusspordis

Thermal Runaway of the 13 kA Busbar Joints in the LHC

CERN Document Server

Verweij, A P

2010-01-01

Triggered by the incident in the LHC in September 2008, the thermo-electrical stability of the 10,000 soldered busbar joints in the 13 kA circuits of the LHC has been re-assessed. For this purpose the computer model QP3 has been developed. In this paper the results of some calculations are presented, and it is shown how the results have been used to improve the quench detection system and ensure safe future operation. First the layout of the 13 kA circuits, the geometry of the soldered joints and the quench detection system will be described. Special focus is put on several types of defects in the joint that have been found in the LHC. The difference between slow and fast thermal run-away will be discussed, focusing on quench propagation and reduced thermal and electrical contacts between the various parts of the joint. It is shown that an enhancement of the LHC quench detection system with a much lower threshold will greatly reduce the risk of burn-out of the joint. Finally it is discussed that protection is...

Anisotropic constant-roll inflation

Energy Technology Data Exchange (ETDEWEB)

Ito, Asuka; Soda, Jiro [Kobe University, Department of Physics, Kobe (Japan)

2018-01-15

We study constant-roll inflation in the presence of a gauge field coupled to an inflaton. By imposing the constant anisotropy condition, we find new exact anisotropic constant-roll inflationary solutions which include anisotropic power-law inflation as a special case. We also numerically show that the new anisotropic solutions are attractors in the phase space. (orig.)

Mimicking the cosmological constant: Constant curvature spherical solutions in a nonminimally coupled model

International Nuclear Information System (INIS)

Bertolami, Orfeu; Paramos, Jorge

2011-01-01

The purpose of this study is to describe a perfect fluid matter distribution that leads to a constant curvature region, thanks to the effect of a nonminimal coupling. This distribution exhibits a density profile within the range found in the interstellar medium and an adequate matching of the metric components at its boundary. By identifying this constant curvature with the value of the cosmological constant and superimposing the spherical distributions arising from different matter sources throughout the universe, one is able to mimic a large-scale homogeneous cosmological constant solution.

Dynamic optical fiber delivery of Ka-band packet transmissions for wireless access networks

DEFF Research Database (Denmark)

Rodríguez Páez, Juan Sebastián; Madsen, Peter; Tafur Monroy, Idelfonso

2017-01-01

A Reconfigurable Radio Access Unit is presented and experimentally demonstrated. In the unit, an optical switching system is set to dynamically deliver different packets to different points in the network. The packets are transmitted wirelesslty on the Ka-band (26–40 GHz), achieving BER values...

Tallinna info- ja abitelefon toetab ka hättasattunud lapsi / Hille Tänavsuu

Index Scriptorium Estoniae

Tänavsuu, Hille, 1941-2014

2006-01-01

Vt. ka Postimees : na russkom jazõke 16. jaan., lk. 5. Infotelefoni projektijuhi Herve Merivaldi sõnul ei sõanda lapsed lastekaitsetöötaja või politsei poole pöörduda. Abitelefonile helistades aitavad dispetsherid neil ühendust saada inimestega, kes neid aidata võivad

Molecular equilibrium structures from experimental rotational constants and calculated vibration-rotation interaction constants

DEFF Research Database (Denmark)

Pawlowski, F; Jorgensen, P; Olsen, Jeppe

2002-01-01

A detailed study is carried out of the accuracy of molecular equilibrium geometries obtained from least-squares fits involving experimental rotational constants B(0) and sums of ab initio vibration-rotation interaction constants alpha(r)(B). The vibration-rotation interaction constants have been...... calculated for 18 single-configuration dominated molecules containing hydrogen and first-row atoms at various standard levels of ab initio theory. Comparisons with the experimental data and tests for the internal consistency of the calculations show that the equilibrium structures generated using Hartree......-Fock vibration-rotation interaction constants have an accuracy similar to that obtained by a direct minimization of the CCSD(T) energy. The most accurate vibration-rotation interaction constants are those calculated at the CCSD(T)/cc-pVQZ level. The equilibrium bond distances determined from these interaction...

Multiproxy evidence for terrestrial and aquatic ecosystem responses during the 8.2 ka cold event as recorded at Højby Sø, Denmark

DEFF Research Database (Denmark)

Hede, Mikkel Ulfeldt; Rasmussen, Peter; Noe-Nygaard, Nanna

2010-01-01

ecosystems to the 8.2 ka cold event. A reduced pollen production by thermophilous deciduous tree taxa in the period c. 8250–8000 cal yr BP reveal that the forest ecosystem was affected by low temperatures during the summer and winter/early-spring seasons. This finding is consistent with the timing of the 8.......2 ka cold event as registered in the Greenland ice cores. At Højby Sø, the climate anomaly appears to have started 200–250 yr earlier than the 8.2 ka cold event as the lake proxy data provide strong evidence for a precipitation-induced distinct increase in catchment soil erosion beginning around 8500...... cal yr BP. Alteration of the terrestrial environment then resulted in a major aquatic ecosystem change with nutrient enrichment of the lake and enhanced productivity, which lasted until c. 7900 cal yr BP. Keywords: 8.2 ka cold event; Lake sediments; Palaeoclimate; Pollen; Macrofossils; Geochemistry...

Optimization of crude oil degradation by Dietzia cinnamea KA1, capable of biosurfactant production.

Science.gov (United States)

Kavynifard, Amirarsalan; Ebrahimipour, Gholamhossein; Ghasempour, Alireza

2016-05-01

The aim of this study was isolation and characterization of a crude oil degrader and biosurfactant-producing bacterium, along with optimization of conditions for crude oil degradation. Among 11 isolates, 5 were able to emulsify crude oil in Minimal Salt Medium (MSM) among which one isolate, named KA1, showed the highest potency for growth rate and biodegradation. The isolate was identified as Dietzia cinnamea KA1 using morphological and biochemical characteristics and 16S rRNA gene sequencing. The optimal conditions were 510 mM NaCl, pH 9.0, 35 °C, and minimal requirement of 46.5 mM NH4 Cl and 2.10 mM NaH2 PO4 . Gravimetric test and Gas chromatography-Mass spectroscopy technique (GC-MS) showed that Dietzia cinnamea KA1 was able to utilize and degrade 95.7% of the crude oil after 5 days, under the optimal conditions. The isolate was able to grow and produce biosurfactant when cultured in MSM supplemented with crude oil, glycerol or whey as the sole carbon sources, but bacterial growth was occurred using molasses with no biosurfactant production. This is the first report of biosurfactant production by D. cinnamea using crude oil, glycerol and whey and the first study to report a species of Dietzia degrading a wide range of hydrocarbons in a short time. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A novel Ka-band coaxial transit-time oscillator with a four-gap buncher

Energy Technology Data Exchange (ETDEWEB)

Song, Lili; He, Juntao; Ling, Junpu [College of Optoelectronic Science and Engineering, National University of Defense Technology, Changsha 410073 (China)

2015-05-15

A novel Ka-band coaxial transit-time oscillator (TTO) with a four-gap buncher is proposed and investigated. Simulation results show that an output power of 1.27 GW and a frequency of 26.18 GHz can be achieved with a diode voltage of 447 kV and a beam current of 7.4 kA. The corresponding power efficiency is 38.5%, and the guiding magnetic field is 0.6 T. Studies and analysis indicate that a buncher with four gaps can modulate the electron beam better than the three-gap buncher in such a Ka-band TTO. Moreover, power efficiency increases with the coupling coefficient between the buncher and the extractor. Further simulation demonstrates that power efficiency can reach higher than 30% with a guiding magnetic field of above 0.5 T. Besides, the power efficiency exceeds 30% in a relatively large range of diode voltage from 375 kV to 495 kV.

Determination of pKa values of diastereomers of phosphinic pseudopeptides by CZE

Czech Academy of Sciences Publication Activity Database

Koval, Dušan; Kašička, Václav; Jiráček, Jiří; Collinsová, Michaela

2006-01-01

Roč. 27, č. 23 (2006), s. 4648-4657 ISSN 0173-0835 R&D Projects: GA ČR(CZ) GA203/04/0098; GA ČR(CZ) GA203/05/2539 Institutional research plan: CEZ:AV0Z40550506 Keywords : diastereomer separation * phosphinic pseudopeptides * pKa determination Subject RIV: CC - Organic Chemistry Impact factor: 4.101, year: 2006

Soil moisture fluctuations recorded in Saharan dust deposits on Lanzarote (Canary Islands) over the last 180 ka

Science.gov (United States)

von Suchodoletz, H.; Oberhänsli, H.; Hambach, U.; Zöller, L.; Fuchs, M.; Faust, D.

2010-08-01

Aeolian sediments trapped in volcanically dammed valleys on Lanzarote, Canary Islands, were investigated in order to reveal environmental changes over the last 180 ka. Clay content and frequency-dependent magnetic susceptibility were used as proxies for pedogenesis and palaeo-soil moisture. During the last 180 ka, these proxies showed a general pattern of enhanced soil moisture during glacials and stadials and more arid conditions during interglacials and interstadials. Comparisons of these results with proxies from regional palaeoclimate studies identified a positive correlation with proxies of trade-wind strength off northwest Africa and inverse correlations with both sea surface temperatures in the northeast Atlantic and the extent of Mediterranean vegetation. Possible causes for the observed pattern include a glacial enhancement of precipitation from westerly cyclones, a change in relative humidity due to fluctuating air temperatures and an occasional influence of the African summer monsoon. Although it is not yet possible to clearly differentiate among these factors, it is clear that the first two factors must have been primarily dominant. These results represent the first quasi-continuous terrestrial data testifying to environmental changes in the northwest African coastal area for the last 180 ka and complement the abundant data derived from marine cores of the region. High latitude dynamics had a major influence in this area and were intermediated by North Atlantic sea surface temperatures. A possible negative correlation can also be observed with the orbital obliquity cycle with a 10 ka time lag, which is similar to the lag recorded from North Atlantic sea surface temperatures.

Stabilized power constant alimentation; Alimentation regulee a puissance constante

Energy Technology Data Exchange (ETDEWEB)

Roussel, L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1968-06-01

The study and realization of a stabilized power alimentation variable from 5 to 100 watts are described. In order to realize a constant power drift of Lithium compensated diodes, we have searched a 1 per cent precision of regulation and a response time minus than 1 sec. Recent components like Hall multiplicator and integrated amplifiers give this possibility and it is easy to use permutable circuits. (author) [French] On decrit l'etude et la realisation d'une alimentation a puissance constante reglable dans une gamme de 5 a 100 watts. Prevue pour le drift a puissance constante des diodes compensees au lithium, l'etude a ete menee en vue d'obtenir une precision de regulation de 1 pour cent et un temps de reponse inferieur a la seconde. Des systemes recents tels que multiplicateurs a effet Hall et circuits integres ont permis d'atteindre ce but tout en facilitant l'emploi de modules interchangeables. (auteur)

Stabilized power constant alimentation; Alimentation regulee a puissance constante

Energy Technology Data Exchange (ETDEWEB)

Roussel, L. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1968-06-01

The study and realization of a stabilized power alimentation variable from 5 to 100 watts are described. In order to realize a constant power drift of Lithium compensated diodes, we have searched a 1 per cent precision of regulation and a response time minus than 1 sec. Recent components like Hall multiplicator and integrated amplifiers give this possibility and it is easy to use permutable circuits. (author) [French] On decrit l'etude et la realisation d'une alimentation a puissance constante reglable dans une gamme de 5 a 100 watts. Prevue pour le drift a puissance constante des diodes compensees au lithium, l'etude a ete menee en vue d'obtenir une precision de regulation de 1 pour cent et un temps de reponse inferieur a la seconde. Des systemes recents tels que multiplicateurs a effet Hall et circuits integres ont permis d'atteindre ce but tout en facilitant l'emploi de modules interchangeables. (auteur)

From the Rydberg constant to the fundamental constants metrology

International Nuclear Information System (INIS)

Nez, F.

2005-06-01

This document reviews the theoretical and experimental achievements of the author since the beginning of his scientific career. This document is dedicated to the spectroscopy of hydrogen, deuterium and helium atoms. The first part is divided into 6 sub-sections: 1) the principles of hydrogen spectroscopy, 2) the measurement of the 2S-nS/nD transitions, 3) other optical frequency measurements, 4) our contribution to the determination of the Rydberg constant, 5) our current experiment on the 1S-3S transition, 6) the spectroscopy of the muonic hydrogen. Our experiments have improved the accuracy of the Rydberg Constant by a factor 25 in 15 years and we have achieved the first absolute optical frequency measurement of a transition in hydrogen. The second part is dedicated to the measurement of the fine structure constant and the last part deals with helium spectroscopy and the search for optical references in the near infrared range. (A.C.)

Status report of the three phase 25 kA, 1.5 kW thermally switched superconducting rectifier, transformer and switches

NARCIS (Netherlands)

ten Kate, Herman H.J.; Holtslag, A.H.M.; Knoben, J.; Steffens, H.A.; van de Klundert, L.J.M.

1983-01-01

A 25 kA, 1.5 kW superconducting rectifier system has been developed. This rectifier system working like an a.c.-d.c, converter with a primary current of 35 A at 0.1Hz, will energize a 25 kA coil with an average power of 5.4 MJ/hr and a proposed energy efficiency of at least 96%. Such a highly

Reconfigurable phased antenna array for extending cubesat operations to Ka-band: Design and feasibility

Science.gov (United States)

Buttazzoni, G.; Comisso, M.; Cuttin, A.; Fragiacomo, M.; Vescovo, R.; Vincenti Gatti, R.

2017-08-01

Started as educational tools, CubeSats have immediately encountered the favor of the scientific community, subsequently becoming viable platforms for research and commercial applications. To ensure competitive data rates, some pioneers have started to explore the usage of the Ka-band beside the conventional amateur radio frequencies. In this context, this study proposes a phased antenna array design for Ka-band downlink operations consisting of 8×8 circularly polarized subarrays of microstrip patches filling one face of a single CubeSat unit. The conceived structure is developed to support 1.5 GHz bandwidth and dual-task missions, whose feasibility is verified by proper link budgets. The dual-task operations are enabled by a low-complexity phase-only control algorithm that provides pattern reconfigurability in order to satisfy both orbiting and intersatellite missions, while remaining adherent to the cost-effective CubeSat paradigm.

An adaptive-binning method for generating constant-uncertainty/constant-significance light curves with Fermi-LAT data

International Nuclear Information System (INIS)

Lott, B.; Escande, L.; Larsson, S.; Ballet, J.

2012-01-01

Here, we present a method enabling the creation of constant-uncertainty/constant-significance light curves with the data of the Fermi-Large Area Telescope (LAT). The adaptive-binning method enables more information to be encapsulated within the light curve than with the fixed-binning method. Although primarily developed for blazar studies, it can be applied to any sources. Furthermore, this method allows the starting and ending times of each interval to be calculated in a simple and quick way during a first step. The reported mean flux and spectral index (assuming the spectrum is a power-law distribution) in the interval are calculated via the standard LAT analysis during a second step. In the absence of major caveats associated with this method Monte-Carlo simulations have been established. We present the performance of this method in determining duty cycles as well as power-density spectra relative to the traditional fixed-binning method.

A re-evaluation of the 0-10 ka 10Be production rate for exposure dating obtained from the Koefels (Austria) landslide

International Nuclear Information System (INIS)

Kubik, Peter W.; Ivy-Ochs, Susan

2004-01-01

The sea level, high latitude 10 Be production rate for exposure dating obtained from the giant 9.8 ka landslide of Koefels (Austria) has been calculated based on a re-assessment of the contribution of the muonic cosmic ray component. The 0-10 ka production rate value is 5.44 ± 0.19 10 Be atoms/y g quartz

The characterization of lactic acid bacteria isolated during the traditional production of Užička sausage

Science.gov (United States)

Borović, B.; Velebit, B.; Vesković, S.; Lakićević, B.; Baltić, T.

2017-09-01

Užička sausage is a traditionally fermented dry sausage that is produced in western Serbia. It is made of beef and pork with the addition of solid fat and natural spices. The whole manufacturing process lasted for 21 days. The goal of this study was to create a collection of lactic acid bacteria isolated during the ripening and identify them using molecular methods. A total of 50 isolates from different stages of ripening (fermentation and drying) were identified by molecular methods. Leuconococcus mesenteroides, Lactobacillus brevis, and Lactobacillus sakei were the predominant microorganisms in Užička sausage.

Food safety knowledge on the Bt mutant protein Cry8Ka5 employed in the development of coleopteran-resistant transgenic cotton plants.

Science.gov (United States)

Farias, Davi F; Peijnenburg, Ad A C M; Grossi-de-Sá, Maria F; Carvalho, Ana F U

2015-01-01

Insecticidal Cry proteins from Bacillus thuringiensis (Bt) have been exploited in the development of genetically modified (GM) crops for pest control. However, several pests are still difficult to control such as the coleopteran boll weevil Anthonomus grandis. By applying in vitro molecular evolution to the cry8Ka1 gene sequence, variants were generated with improved activity against A. grandis. Among them, Cry8Ka5 mutant protein showed coleoptericidal activity 3-fold higher (LC50 2.83 μg/mL) than that of the original protein (Cry8Ka1). Cry8Ka5 has been used in breeding programs in order to obtain coleopteran-resistant cotton plants. Nevertheless, there is some concern in relation to the food safety of transgenic crops, especially to the heterologously expressed proteins. In this context, our research group has performed risk assessment studies on Cry8Ka5, using the tests recommended by Codex as well as tests that we proposed as alternative and/or complementary approaches. Our results on the risk analysis of Cry8Ka5 taken together with those of other Cry proteins, point out that there is a high degree of certainty on their food safety. It is reasonable to emphasize that most safety studies on Cry proteins have essentially used the Codex approach. However, other methodologies would potentially provide additional information such as studies on the effects of Cry proteins and derived peptides on the indigenous gastrointestinal microbiota and on intestinal epithelial cells of humans. Additionally, emerging technologies such as toxicogenomics potentially will offer sensitive alternatives for some current approaches or methods.

CONSTANT LEVERAGE AND CONSTANT COST OF CAPITAL: A COMMON KNOWLEDGE HALF-TRUTH

Directory of Open Access Journals (Sweden)

IGNACIO VÉLEZ-PAREJA

2008-01-01

Full Text Available Un enfoque típico para valorar flujos de caja finitos es suponer que el endeudamiento es constante (generalmente como un endeudamiento objetivo o deseado y que por tanto, el costo del patrimonio, Ke y el costo promedio ponderado de capital CPPC, también son constantes. Para los flujos de caja perpetuos, y con el costo de la deuda, Kd como la tasa de descuento para el ahorro en impuestos o escudo fiscal, Ke y el CPPC aplicado al flujo de caja libre FCL son constantes si el endeudamiento es constante. Sin embargo esto no es verdad para los flujos de caja finitos. En este documento mostramos que para flujos de caja finitos, Ke y por lo tanto el CPPC dependen de la tasa de descuento que se utiliza para valorar el ahorro en impuestos, AI y según lo esperado, Ke y el CPPC no son constantes con Kd como la tasa de descuento para el ahorro en impuestos, aunque el endeudamiento sea constante. Ilustramos esta situación con un ejemplo simple. Analizamos cinco métodos: el flujo de caja descontado, FCD, usando APV, el FCD y la formulación tradicional y general del CPPC, el valor presente del flujo de caja del accionista, FCA más deuda y el flujo de caja de capital, FCC.

Clinical Course of Homozygous Hemoglobin Constant Spring in Pediatric Patients.

Science.gov (United States)

Komvilaisak, Patcharee; Jetsrisuparb, Arunee; Fucharoen, Goonnapa; Komwilaisak, Ratana; Jirapradittha, Junya; Kiatchoosakun, Pakaphan

2018-04-17

Hemoglobin (Hb) Constant Spring is an alpha-globin gene variant due to a mutation of the stop codon resulting in the elongation of the encoded polypeptide from 141 to 172 amino acid residues. Patients with homozygous Hb Constant Spring are usually mildly anemic. We retrospectively describe clinical manifestations, diagnosis, laboratory investigations, treatment, and associated findings in pediatric patients with homozygous Hb Constant Spring followed-up at Srinagarind Hospital. Sixteen pediatric cases (5 males and 11 females) were diagnosed in utero (N=6) or postnatal (n=10). Eleven cases were diagnosed with homozygous Hb Constant Spring, 4 with homozygous Hb Constant Spring with heterozygous Hb E, and 1 with homozygous Hb Constant Spring with homozygous Hb E. Three cases were delivered preterm. Six patients had low birth weights. Clinical manifestations included fetal anemia in 6 cases, hepatomegaly in 1 case, hepatosplenomegaly in 2 cases, splenomegaly in 1 case. Twelve cases exhibited early neonatal jaundice, 9 of which required phototherapy. Six cases received red cell transfusions; 1 (3), >1 (3). After the first few months of life, almost all patients had mild microcytic hypochromic anemia and an increased reticulocyte count with a wide red cell distribution (RDW), but no longer required red cell transfusion. At 1 to 2 years of age, some patients still had mild microcytic hypochromic anemia and some had normocytic hypochromic anemia with Hb around 10 g/dL, increased reticulocyte count and wide RDW. Associated findings included hypothyroidism (2), congenital heart diseases (4), genitourinary abnormalities (3), gastrointestinal abnormalities (2), and developmental delay (1). Pediatric patients with homozygous Hb Constant Spring developed severe anemia in utero and up to the age of 2 to 3 months postnatal, requiring blood transfusions. Subsequently, their anemia was mild with no evidence of hepatosplenomegaly. Their Hb level was above 9 g/dL with hypochromic

Asetonitril-Su İkili Karışımlarında Piroksikam ve Tenoksikam'ın Potansiyometrik pKa Tayini

OpenAIRE

Çubuk Demiralay, Ebru; Yılmaz, Hülya

2012-01-01

İyonlaşma sabiti (pKa) çözünebilirlik sınırlaması olmaksızın doğru tahmin edilebilen parametrelerden birisidir. Sunulan bu çalışmada, piroksikam ve tenoksikamın asit- baz davranışı çalışılmıştır. Potansiyometrik metot kullanılarak, piroksikam ve tenoksikamın pKa değerleri asetonitril-su ikili karışımlarının farklı yüzdelerinde tayin edilmiştir (asetonitril içeriği hacimce % 30 ile 45 arasında). Bu bileşiklerin sudaki pKa değerleri mol kesri ve Yasuda-Shedlovsky eşitlikleri kullanarak hesaplan...

Enne võõrandamist uppunud auriku eest saab ka hüvitust / Hille Tänavsuu

Index Scriptorium Estoniae

Tänavsuu, Hille, 1941-2014

2006-01-01

Tallinna linnavalitsuse otsusest kompenseerida kuue, 1940. aasta oktoobris õigusvastaselt võõrandatud, aurulaeva mõttelisi osi. Laevadega seotud probleemist ka laiemalt ning laevade saatusest. Lisatud: mis on õigusvastaselt võõrandatud vara

Sequence preservation of osteocalcin protein and mitochondrial DNA in bison bones older than 55 ka

Science.gov (United States)

Nielsen-Marsh, Christina M.; Ostrom, Peggy H.; Gandhi, Hasand; Shapiro, Beth; Cooper, Alan; Hauschka, Peter V.; Collins, Matthew J.

2002-12-01

We report the first complete sequences of the protein osteocalcin from small amounts (20 mg) of two bison bone (Bison priscus) dated to older than 55.6 ka and older than 58.9 ka. Osteocalcin was purified using new gravity columns (never exposed to protein) followed by microbore reversed-phase high-performance liquid chromatography. Sequencing of osteocalcin employed two methods of matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS): peptide mass mapping (PMM) and post-source decay (PSD). The PMM shows that ancient and modern bison osteocalcin have the same mass to charge (m/z) distribution, indicating an identical protein sequence and absence of diagenetic products. This was confirmed by PSD of the m/z 2066 tryptic peptide (residues 1 19); the mass spectra from ancient and modern peptides were identical. The 129 mass unit difference in the molecular ion between cow (Bos taurus) and bison is caused by a single amino-acid substitution between the taxa (Trp in cow is replaced by Gly in bison at residue 5). Bison mitochondrial control region DNA sequences were obtained from the older than 55.6 ka fossil. These results suggest that DNA and protein sequences can be used to directly investigate molecular phylogenies over a considerable time period, the absolute limit of which is yet to be determined.

Pollen-based evidence of extreme drought during the last Glacial (32.6-9.0 ka) in coastal southern California

Science.gov (United States)

Heusser, Linda E.; Kirby, Matthew E.; Nichols, Jonathan E.

2015-10-01

High resolution pollen analyses of sediment core LEDC10-1 from Lake Elsinore yield the first well-dated, terrestrial record of sub-centennial-scale ecologic change in coastal southern California between ˜32 and 9 ka. In the Lake Elsinore watershed, the initial, mesic montane conifer forests dominated by Pinus, and Cupressaceae with trace amounts of Abies and Picea were replaced by a sequence of multiple, extended severe mega-droughts between ˜27.5 and ˜25.5 ka, in which halophytic and xerophytic herbs and shrubs occupied an ephemeral lake. This prolonged and extended dry interval, which corresponds with warm waters offshore, imply strengthening of the North Pacific High and persistent below-average winter precipitation. The subsequent, contrasting monotonic occurrence of montane conifers reflects little variation in cold, mesic climate until ˜15 ka. Postglacial development of Quercus woodland and chaparral mark the return to more xeric, warmer conditions at this time. A brief reversal at ˜13.1-˜12.1 ka, as reflected by an expansion of Pinus, is correlative with the Younger Dryas and interrupts development of warm, postglacial climate. Subsequent gradual expansion of xeric vegetation post - Younger Dryas denotes the establishment of a winter hydroclimate regime in coastal southern California that is more similar to modern conditions. Pollen-based reconstructions of temperature and precipitation at Lake Elsinore are generally correlative with pollen-based paleoclimatic reconstructions and foraminifera-based sea surface temperatures from Santa Barbara Basin in marine core ODP 893. The conspicuous absence of the ˜27.5-˜25.5 ka glacial "mega-drought" in the Santa Barbara Basin pollen record highlights the sensitivity of Lake Elsinore to hydroclimate change, and thus, the importance of this new record that indicates that mega-drought can occur during the full glacial when climatic boundary conditions and forcings differed substantially from the present.

Dust records in the Pleistocene sediments of Fraser Island: palaeoclimatic reconstruction of wind erosion over the last 600 ka

International Nuclear Information System (INIS)

Longmore, M.E.; McTainsh, G.H.

1997-01-01

Full text: Pleistocene lake sediments from a relic perched freshwater lake on Fraser Island have been found to date back to ca.600 ka using U/Th analysis of the organics. This sequence is one of the three longest terrestrial records of environmental change in Australia and the contained evidence of vegetation, fire and lake level changes (Longmore and Heijnis, 1996) and is an invaluable contribution to palaeoclimatic reconstruction. A younger sequence, dated by conventional radiocarbon analysis, has 6.5 m of continuous organic sedimentation from ca. 30 ka to the present. The last 8.5 ka has been analysed in detail, showing a mid-Holocene 'dry' period (Longmore, 1996). Continental aeolian dust from extreme wind erosional events has been measured in modern atmospheres (McTainsh, 1989; Knight et al., 1995) and deep sea cores (Hesse, 1994), but the terrestrial record of wind erosion during the Pleistocene is sparse. We will report on a pilot project to determine the presence of aeolian dust from extreme wind erosional events in the past in the sediments of Fraser Island lakes. Due to the highly weathered, well-sorted, siliceous nature of the dune sands forming the Island and the highly organic nature of the lake sediments (80-95% LOI), these are some of the few terrestrial sequences that permit separation of aeolian dust from local catchment materials. In the future, oxygen isotope and XRD analysis of the extracted dust will allow the most likely source of the entrained material to be determined and thus provide further evidence as to the wind regime during the last 600ka and 30ka respectively. The separation of dust from these terrestrial sequences is a major achievement and potentially may make a significant contribution to global palaeoclimatic models

Learning Read-constant Polynomials of Constant Degree modulo Composites

DEFF Research Database (Denmark)

Chattopadhyay, Arkadev; Gavaldá, Richard; Hansen, Kristoffer Arnsfelt

2011-01-01

Boolean functions that have constant degree polynomial representation over a fixed finite ring form a natural and strict subclass of the complexity class \\textACC0ACC0. They are also precisely the functions computable efficiently by programs over fixed and finite nilpotent groups. This class...... is not known to be learnable in any reasonable learning model. In this paper, we provide a deterministic polynomial time algorithm for learning Boolean functions represented by polynomials of constant degree over arbitrary finite rings from membership queries, with the additional constraint that each variable...

Determination of Henry's constant, the dissociation constant, and the buffer capacity of the bicarbonate system in ruminal fluid.

Science.gov (United States)

Hille, Katharina T; Hetz, Stefan K; Rosendahl, Julia; Braun, Hannah-Sophie; Pieper, Robert; Stumpff, Friederike

2016-01-01

Despite the clinical importance of ruminal acidosis, ruminal buffering continues to be poorly understood. In particular, the constants for the dissociation of H2CO3 and the solubility of CO2 (Henry's constant) have never been stringently determined for ruminal fluid. The pH was measured in parallel directly in the rumen and the reticulum in vivo, and in samples obtained via aspiration from 10 fistulated cows on hay- or concentrate-based diets. The equilibrium constants of the bicarbonate system were measured at 38°C both using the Astrup technique and a newly developed method with titration at 2 levels of partial pressure of CO2 (pCO2; 4.75 and 94.98 kPa), yielding mean values of 0.234 ± 0.005 mmol ∙ L(-1) ∙ kPa(-1) and 6.11 ± 0.02 for Henry's constant and the dissociation constant, respectively (n/n = 31/10). Both reticular pH and the pH of samples measured after removal were more alkalic than those measured in vivo in the rumen (by ΔpH = 0.87 ± 0.04 and 0.26 ± 0.04). The amount of acid or base required to shift the pH of ruminal samples to 6.4 or 5.8 (base excess) differed between the 2 feeding groups. Experimental results are compared with the mathematical predictions of an open 2-buffer Henderson-Hasselbalch equilibrium model. Because pCO2 has pronounced effects on ruminal pH and can decrease rapidly in samples removed from the rumen, introduction of a generally accepted protocol for determining the acid-base status of ruminal fluid with standard levels of pCO2 and measurement of base excess in addition to pH should be considered. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Denudational slope processes on weathered basalt in northern California: 130 ka history of soil development, periods of slope stability and colluviation, and climate change

Science.gov (United States)

McDonald, Eric; Harrison, Bruce; Baldwin, John; Page, William; Rood, Dylan

2017-04-01

The geomorphic history of hillslope evolution is controlled by multiple types of denudational processes. Detailed analysis of hillslope soil-stratigraphy provides a means to identify the timing of periods of slope stability and non-stability, evidence of the types of denudational processes, and possible links to climatic drivers. Moreover, the degree of soil formation and the presence of buried or truncated soils provide evidence of the relative age of alternating periods of colluviation and stability. We use evaluation of soil stratigraphy, for a small forested hillslope (soils and slope colluvium are derived from highly weathered basalt. Stratigraphic interpretation is reinforced with soil profile development index (PDI) derived age estimates, tephrochronology, luminescence ages on colluvium, and He3 nuclide exposure dates. Soils formed along hilltop ridges are well developed and reflect deep (>2-3 m) in-situ weathering of the basalt bedrock. PDI age estimates and He3 exposure dates indicate that these hilltop soils had been in place for 100-130 ka, implying a long period of relative surface stability. At about 40-30 ka, soil stratigraphy indicates the onset of 3 distinct cycles of denudation of the hilltop and slopes. Evidence for changes in stability and onset of soil erosion is the presence of several buried soils formed in colluvium downslope of the hilltop. These buried soils have formed in sediment derived from erosion of the hilltop soils (i.e. soil parent material of previously weathered soil matrix and basalt cobbles). The oldest buried soil indicates that slope stability was re-established between 32-23 ka, with stability and soil formation lasting to about 10 ka. Soil-stratigraphy indicates that two additional intervals of downslope transport of sediment between 6-10 ka, and 2-5 ka. Soil properties indicate that the primary method of downslope transport is largely due to tree throw and faunal burrowing. Onset of slope instability at 40-30 ka appears to

Rimi toob Eesti liha lettidele ka Poola kaudu / Urmas Jaagant, Agnes Ojala

Index Scriptorium Estoniae

Jaagant, Urmas

2010-01-01

Lihatootjate ja Poolas asuvat pakendamiskeskust pidava Hilton Foodsi vahel jätkuvad läbirääkimised, et sõlmida ekspordilepingud. Hilton Foods töötleb ja pakendab nii Eesti kui ka teiste riikide liha ning müüb selle Rimi kaubamärgi all Leedu, Läti, Ungari, Eesti jt. riikide poodidele. Rimi turundusjuhi Evelin Mägioja selgitusi

Atypical delta N-15 variations at the southern boundary of the East Pacific oxygen minimum zone over the last 50 ka

OpenAIRE

P. Martinez; F. Lamy; R. R. Robinson; L. Pichevin; I. Billy;  

2006-01-01

We report a nitrogen isotope record (ODP Site 1233) from the southern Chile margin at 41�S. The site is located slightly south of the southern boundary of the Peru�Chile upwelling system and the associated oxygen minimum zone off Peru and northern Chile. We show that our nitrogen isotope record, from the time interval 0�50 calendar kiloyears before present (ka B.P.), bears an atypical pattern both in shape and timing when compared with records obtained from either the continental margin...

Past climate variability between 97 and 7 ka reconstructed from a multi proxy speleothem record from Western Cuba

Science.gov (United States)

Winterhalder, Sophie; Scholz, Denis; Mangini, Augusto; Spötl, Christoph; Jochum, Klaus Peter; Pajón, Jesús M.

2016-04-01

The tropical hydrological cycle plays a key role in regulating global climate, mainly through the export of heat and moisture to higher latitudes, and is highly sensitive to climate change, for instance due to changes in the position of the Intertropical Convergence Zone (ITCZ). Previous work on Caribbean stalagmites suggests a strong connection of precipitation variability to North Atlantic (NA) sea surface temperatures on multidecadal to millenial timescales (Fensterer et al., 2012; Fensterer et al., 2013; Winter et al., 2011). Cold phases in the NA potentially lead to a southward shift of the ITCZ and thus drier conditions in Cuba. On orbital timescales, Cuban stalagmites suggest a relation of speleothem δ18O values with the δ18O value of Caribbean surface waters (Fensterer et al., 2013). Here we present an expansion of the Cuban speleothem record covering the whole last glacial period from the end of MIS5c (97 ka BP) until 7 ka with hiatuses between 93-80 ka, 37-35 ka and 13-10 ka. Stalagmite Cuba medio (CM) has been precisely dated with 60 230Th/U-ages, mainly performed by the MC-ICPMS technique. The δ18O and δ13C records are completed by a continuous, high resolution LA-ICPMS trace element profile. These data allow for the first time to establish a multi-proxy climate reconstruction for the North Western Caribbean at decadal to centennial resolution for this period. The long-term variability of the δ18O values probably reflects rainfall amount in Cuba. The response to some Dansgaard/Oeschger and Heinrich stadials confirms the previously observed correlation between Caribbean and NA climate variability. However, this connection is not clearly imprinted throughout the record. Furthermore, trace elements, such as Mg, do not proof without ambiguity drier conditions in Cuba during NA cold events, such as the Heinrich stadials. This suggests that climate variability in Cuba was more complex during the last 100ka, and that the NA was not the only driving factor

Constant leverage and constant cost of capital : A common knowledge half-truth

OpenAIRE

Vélez Pareja, Ignacio; Ibragimov, Rauf; Tham , Joseph

2008-01-01

Un enfoque típico para valorar flujos de caja finitos es suponer que el endeudamiento es constante (generalmente como un endeudamiento objetivo o deseado) y que por tanto, el costo del patrimonio, Ke y el costo promedio ponderado de capital CPPC, también son constantes. Para los flujos de caja perpetuos, y con el costo de la deuda, Kd como la tasa de descuento para el ahorro en impuestos o escudo fiscal, Ke y el CPPC aplicado al flujo de caja libre FCL son constantes si el endeudamiento es co...

"Parim" on subjektiivne, aga kõhutundest ka ei piisa / Inga Kuusik

Index Scriptorium Estoniae

Kuusik, Inga, 1961-

2007-01-01

Ilmunud ka: Finansovõi Menedzhment : infovõpusk nr. 13 apr. lk. 6-7. Saku Õlletehase uus finantsjuht oma tööst tubakatootja Imperial Tobacco Grupi Kesk-Aasia regiooni finantsdirektorina Kõrgõzstanis, Saku Õlletehase kapitali struktuurist, finantsdirektori rollist ettevõttes ja tööjõu värbamisest Saku Õlletehases. Lisad: Saku Õlletehas 2006: mõõdukas käibe-, aga suur kasumikasv; Tabel: Saku Õlletehase dividendimaksed 1997-2007

The reconstruction of easterly wind directions for the Eifel region (Central Europe during the period 40.3–12.9 ka BP

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K. Seelos

2010-03-01

Full Text Available A high resolution continuous reconstruction of last glacial wind directions is based on provenance analysis of eolian sediments in a sediment core from the Dehner dry Maar in the Eifel region (Germany. This Maar is suitable to archive easterly wind directions due to its location west of the Devonian carbonate basins of the Eifel-North-South-Zone. Thus, eolian sediments with high clastic carbonate content can be interpreted as an east wind signal. The detection of such east wind sediments is applied by a new module of the RADIUS grain size analyze technique. The investigated time period from 40.3–12.9 ka BP can be subclassified in three units: The first unit covers the periods of the ending GIS-9, H4, and GIS-8. With the exception of H4 (40–38 ka BP the content of organics in our record is relatively high. With the end of GIS-8 (38–36.5 ka the content of organics decrease and the content of dust increases rapidly. The second time slice (36–24 ka BP has an increased content of dust accumulation and a high amount of east winds layers (up to 19% of the dust storms per century came from the east. In comparison, the subsequent period (24–12.9 ka BP is characterized by lower east wind sediments again. Increased frequencies of east wind occur during the time intervals corresponding with the Heinrich events H1 and H2. The unusual H3 show no higher east wind frequency but so do its former and subsequent Greenland stadials. The late LGM (21–18 ka BP is characterized by a slightly elevated east wind frequency again.

Lead-Lag relationships? Asynchrounous and Abrupt Shifts in Atmospheric Circulation, Temperature, and Vegetation during the 8.2 ka Event in the Eastern Mediterranean at Tenaghi Philippon, Greece

Science.gov (United States)

Niedermeyer, E. M.; Mulch, A.; Pross, J.

2017-12-01

The "8.2 ka event" has been an abrupt and prominent climate perturbation during the Holocene, and is characterized by an episode of generally colder and dryer conditions in the Northern Hemisphere realm. However, evidence to what extent this event has had an impact on climate in the Mediterranean region is ambiguous, in particular with respect to rainfall, temperature and vegetation change on land. Here we present a new, high-resolution record (ø 15 years during the event) of paleotemperatures from the Tenaghi Philippon peat deposit, Eastern Macedonia, Greece, using the MBT'/CBT index based on brGDGTs (branched Glycerol-Dialkyl-Glycerol-Tetraethers). Our data show fairly stable temperatures before the event, which is initiated at 8.1 ka by an abrupt and continuous cooling during the first 35 years of the event. After a short, 10-year episode of minimum temperatures, the event is ended by a similarly abrupt and continuous warming within 38 years. Comparison of our record with a previous study of the stable hydrogen isotopic composition of higher-plant waxes (δDwax) on the same core1 shows that changes in temperature occurred simultaneously with shifts in atmospherics moisture sources (Mediterranean vs Atlantic). Interestingly, further comparison of our data with a previous palynological study of the same core2 reveals that changes in vegetation associated with the 8.2 ka event precede shifts in hydrology and temperature by 100 years. This suggests either pronounced changes in seasonality of temperature and rainfall after the onset of the 8.2 ka event, i.e. at the peak of the event, or that changes in local atmospheric circulation (moisture sources) and temperature where not the initial trigger of changes in vegetation. References: Pross, J., Kotthoff, U., Müller, U.C., Peyron, O., Dormoy, I., Schmiedl, G., Kalaitzidis, S. and Smith, A.M. (2009): Massive perturbation in terrestrial ecosystems of the Eastern Mediterranean region associated with the 8.2 kyr B

Crippled song. Ręka by Bolesław Leśmian within the context of expressionistic poetry

Directory of Open Access Journals (Sweden)

Katarzyna Szewczyk-Haake

2009-01-01

Full Text Available The analysis of Leśmian’s poem Ręka (from the collection of poems entitled Łąka, 1920 leads to distinguishing certain features of the poem that make a connection of the poem with literary expressionism feasible. The above similarities can be testified not only by distinct macabre motifs but also a very peculiar way the narrator constructs his narrative that can be concluded as an attempt at establishing a particular bond between the protagonist and the reader. Works written by the Poznań based expressionists Stanisław Kubicki and Józef Wittlin provide the appropriate context for the poem.

4-N, 4-S & 4-O Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pKa on Activity vs. Chloroquine Resistant Malaria+, #

Science.gov (United States)

Natarajan, Jayakumar K.; Alumasa, John; Yearick, Kimberly; Ekoue-Kovi, Kekeli A.; Casabianca, Leah B.; de Dios, Angel C.; Wolf, Christian; Roepe, Paul D.

2009-01-01

Using predictions from heme – quinoline antimalarial complex structures, previous modifications of chloroquine (CQ), and hypotheses for chloroquine resistance (CQR), we synthesize and assay CQ analogues that test structure – function principles. We vary side chain length for both monoethyl and diethyl 4N CQ derivatives. We alter the pKa of the quinolyl N by introducing alkylthio or alkoxy substituents into the 4 position, and vary side chain length for these analogues. We introduce an additional titratable amino group to the side chain of 4O analogues with promising CQR strain selectivity and increase activity while retaining selectivity. We solve atomic resolution structures for complexes formed between representative 4N, 4S and 4O derivatives vs. μ-oxo dimeric heme, measure binding constants for monomeric vs. dimeric heme, and quantify hemozoin (Hz) formation inhibition in vitro. The data provide additional insight for the design of CQ analogues with improved activity vs. CQR malaria. PMID:18512900

Planck Constant Determination from Power Equivalence

Science.gov (United States)

Newell, David B.

2000-04-01

Equating mechanical to electrical power links the kilogram, the meter, and the second to the practical realizations of the ohm and the volt derived from the quantum Hall and the Josephson effects, yielding an SI determination of the Planck constant. The NIST watt balance uses this power equivalence principle, and in 1998 measured the Planck constant with a combined relative standard uncertainty of 8.7 x 10-8, the most accurate determination to date. The next generation of the NIST watt balance is now being assembled. Modification to the experimental facilities have been made to reduce the uncertainty components from vibrations and electromagnetic interference. A vacuum chamber has been installed to reduce the uncertainty components associated with performing the experiment in air. Most of the apparatus is in place and diagnostic testing of the balance should begin this year. Once a combined relative standard uncertainty of one part in 10-8 has been reached, the power equivalence principle can be used to monitor the possible drift in the artifact mass standard, the kilogram, and provide an accurate alternative definition of mass in terms of fundamental constants. *Electricity Division, Electronics and Electrical Engineering Laboratory, Technology Administration, U.S. Department of Commerce. Contribution of the National Institute of Standards and Technology, not subject to copyright in the U.S.

Comparative study by infrared spectrometry of the behaviour of Y-H and Y-D groups. Valencies frequency and molecular association constants; Etude comparee par spectrometrie infrarouge du comportement de groupements YH et YD. Frequences de valence et constantes d'association moleculaires

Energy Technology Data Exchange (ETDEWEB)

Leicknam, J P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1966-02-01

In the first part of the report a comparison is made of the relative lowering of the frequencies determined using homologous hydrogenated and deuterated vibrators dissolved in various solvents, with the gaseous state as reference. It is confirmed that one always has ({delta}{nu}/{nu}{sub g}){sub YH} {>=} ({delta}{nu}/{nu}{sub g}){sub YD}. Certain results suggest the existence of interactions between vibrational and electronic states, but the different behaviours of OH and OD molecules and of NH and deuterated-N compounds show that the phenomenon is complex. In the second part of the report a quantitative examination is made of about a hundred molecular associations which are formed in solution in an inert solvent by means of hydrogen or deuterium bridges. The proton and deuton donor auto-associations are studied first of all, the association constants K{sub H} are then determined for the proton donors with various acceptors, as are the K{sub D}/K{sub H} ratios obtained after partial substitution in these donors of the hydrogen by deuterium. The results show that it is necessary to distinguish thermo-dynamic effects (which can be calculated when all frequencies of the free dynamic and complexed molecules, are known) and chemical effects connected with the nature of the donors and acceptors; among these latter, the possible formation of 'ionic pairs' has without doubt a great influence on the direction of the isotopic effect. (author) [French] Dans une prerrere partie, en prenant l'etat gazeux comme reference, on compare les abaissements relatifs de frequence determinee avec des vibrateurs hydrogenes et deuteries homologues dissous dans divers solvants. On confirme que l'on a toujours ({delta}{nu}/{nu}{sub g}){sub YH} {>=} ({delta}{nu}/{nu}{sub g}){sub YD}. Certains resultats conduisent a envisager l'existence d'interactions entre etats vibratoires et electroniques, mais le comportement different des molecules OH et OD et des composes NH et N-deuteries montre que le

PROPOSAL HOW TO RECONSTRUCT THE ROŠKA MULTI-STOREY

Directory of Open Access Journals (Sweden)

Blaž Vogelnik

2013-01-01

Full Text Available We have known for years that the residential towers on Roška Street are absolutely the most problematic buildings in Ljubljana in terms of their seismic safety. We decided to propose the rehabilitation of these structures in line with a "new philosophy" according to which the building interiors are left unaffected, and all the necessary reinforcements are implemented externally. During rehabilitation works, the building is not deprived of its habitational function. We developed the "nothing within – all without" philosophy back in 1981 for the rehabilitation of a big hotel near Makarska (we also took out a patent for it then. It is also essential to note that, apart from adequate seismic reinforcement, we gain new residential floor areas which generally cover all rehabilitation costs. In the case of the residential towers on Roška Street, we envisaged additional reinforced concrete walls for the entire perimeter of the towers. These walls are "stabilised" with a 3 m wide console slab running all around each floor, thus adding approximately 65 sqm of additional floor area to every apartment, which amounts to a little more than the net apartment floor area. Before setting up the new additional perimeter walls, we place 15 cm of insulation in between which considerably reduces the use of heating energy and eliminates all "thermal bridges". The old perimeter walls are connected to the new ones by Ø 22 mm inox steel treenails (with weak thermal conductivity. Since the existing structures are no longer settling, all of the new perimeter walls will be founded on Jet-Grouted columns.

FORMATION CONSTANTS AND THERMODYNAMIC ...

African Journals Online (AJOL)

KEY WORDS: Metal complexes, Schiff base ligand, Formation constant, DFT calculation ... best values for the formation constants of the proposed equilibrium model by .... to its positive charge distribution and the ligand deformation geometry.

Pension tuleb maal tasuta koju ka tulevikus / Siim-Valmar Kiisler

Index Scriptorium Estoniae

Kiisler, Siim, 1965-

2008-01-01

Regionaalminister Siim-Valmar Kiisleri sõnul toetas riigikogu sotsiaalkomisjon tema ettepanekut ning otsustas kirjutada eelnõusse sisse sätte, et hajaasustusega piirkondades ning asulates, kus pangateenused pole kättesaadavad, jääb pensionide ning hüvitiste kojukanne edaspidigi tasuta. Ilmunud ka: Harju Elu 17. okt. lk. 2, Vooremaa 16. okt. lk. 2; Harju Elu 17. okt. lk. 2; Kuulutaja 17. okt. lk. 4; Võrumaa Teataja 18. okt. lk. 2; Meie Maa 16. okt. lk. 2; Koit 21. okt. lk. 6; Sakala 22. okt. lk. 2; Oma Saar 23. okt. lk. 5

Health of primary teachers in Obalno-kraška region

OpenAIRE

Lavrič, Katja

2013-01-01

The purpose of the dissertation was to evaluate the health of elementary school teachers teaching in the southwestern part of Slovenia, in the so-called Obalno-kraška region. The main goals were to determine how often do these teachers engage in physical activity, how frequently are they absent from work due to health problems, how often do they feel tense, under stress or under severe pressure and how do they deal with it, how many of them smoke or live in a smoking environment, what is thei...

Water shortage and drought monitoring in Bačka region (Vojvodina, North Serbia: Setting-up measurement stations network

Directory of Open Access Journals (Sweden)

Jovanović Mlađen

2013-01-01

Full Text Available Water shortage and drought, as the most important hydro-climatic hazards, cause significant damages in case of most continents including SE Europe. An experimental field established in Bačka region (Vojvodina Autonomous Province, North Serbia for the purpose of droughts/water shortage monitoring and remote sensing under ongoing IPA project 'Water shortage hazard and adaptive water management strategies in the Hungarian-Serbian cross-border region' (WAHASTRAT. The main objective of this project is to determine water shortage con­flicts on a local and regional level, and to reveal the frequency, extent and severity of future hydro-cli­matic hazards. The locations of eight measurement stations selected on the principle of representativeness in term of terrain configuration and soil cover. An area in which measurement stations were placed, covers about 1000 km2 (12% of total area of Bačka and includes geomorphic units which reliable represent the relief of the whole Bačka region. Measurement stations were placed on 4 out of 5 most common soil types in the Bačka and Vojvodina: chernozem, alluvial soils, smonitza and saline and alkali soils. A measurement equipment system was constructed for the requirements of the WAHASTRAT project. The aim was to design a user-friendly and affordable IT solution, which would enable continuous re­mote monitoring of meteorological parameters and soil moisture. Independent solar-powered meas­urement stations are able to automatically measure air temperature, air humidity, wind speed, wind di­rection, precipitation and soil moisture.

Berliini filmifestivalil näeb ka Peeter Simmi filmi "Head käed" / Triin Tael

Index Scriptorium Estoniae

Tael, Triin

2002-01-01

Berliini 52. filmifestival algas eile sakslase Tom Tykweri mängufilmiga "Taevas". Esmakordselt on festivali "Panorama" kavas eesti mängufilm, milleks on Peeter Simmi "Head käed". Eesti filmid on esil ka festivali suurel filmiturul

Accelerating Sequential Gaussian Simulation with a constant path

Science.gov (United States)

Nussbaumer, Raphaël; Mariethoz, Grégoire; Gravey, Mathieu; Gloaguen, Erwan; Holliger, Klaus

2018-03-01

Sequential Gaussian Simulation (SGS) is a stochastic simulation technique commonly employed for generating realizations of Gaussian random fields. Arguably, the main limitation of this technique is the high computational cost associated with determining the kriging weights. This problem is compounded by the fact that often many realizations are required to allow for an adequate uncertainty assessment. A seemingly simple way to address this problem is to keep the same simulation path for all realizations. This results in identical neighbourhood configurations and hence the kriging weights only need to be determined once and can then be re-used in all subsequent realizations. This approach is generally not recommended because it is expected to result in correlation between the realizations. Here, we challenge this common preconception and make the case for the use of a constant path approach in SGS by systematically evaluating the associated benefits and limitations. We present a detailed implementation, particularly regarding parallelization and memory requirements. Extensive numerical tests demonstrate that using a constant path allows for substantial computational gains with very limited loss of simulation accuracy. This is especially the case for a constant multi-grid path. The computational savings can be used to increase the neighbourhood size, thus allowing for a better reproduction of the spatial statistics. The outcome of this study is a recommendation for an optimal implementation of SGS that maximizes accurate reproduction of the covariance structure as well as computational efficiency.

Identifikace – co odhalí zubní lékařství? Kazuistika

Czech Academy of Sciences Publication Activity Database

Dostálová, T.; Eliášová, H.; Fojtášek, L.; Zvárová, Jana; Teuberová, Z.; Seydlová, M.

2007-01-01

Roč. 17, č. 4 (2007), s. 16-19 ISSN 1210-3381 R&D Projects: GA AV ČR 1ET200300413 Institutional research plan: CEZ:AV0Z10300504 Keywords : zubní lékařství * forenzní * identifikace Subject RIV: EC - Immunology

Spatiotemporal changes of land use patterns in high mountain areas of Northeast Turkey: a case study in Maçka.

Science.gov (United States)

Sen, Gokhan; Bayramoglu, Mahmut M; Toksoy, Devlet

2015-08-01

High mountain forests (HMFs) have an important significance in forest ecosystems, but the benefits from such ecosystems have been compromised in recent years. In Turkey, HMFs constitute significant portions of Turkish forests because they cover 4% of Turkey; 15% of all Turkish forest areas are HMFs. The Eastern Black Sea region has a particular importance for HMFs due to its biological diversity and the rich presence of endemic species. This study analyzes the changes in spatial and temporal patterns of forest cover in HMF from 1973 to 2008 in the town of Maçka, which is located at the center of the Eastern Black Sea region of Turkey. The spatial and temporal change patterns of land use are quantified by interpreting spatial data. Remote sensing (RS), geographical information system (GIS), and a spatial pattern analysis program for categorical maps (FRAGSTATS) have been used for data collection, analysis, and presentation. The results showed that the HMF areas had biphasic growth from 1973 to 2008. Despite a net increase of 200.6 ha in forested areas between 1984 and 2008, there was an overall decrease from 1973 to 2008. The annual percentage of forestation for the forest areas within the study period was 0.04% in Maçka. The amount of aggregated forest area fragments rose from 388 in 1973 to 711 in 2008. The increase in the HMF of Maçka can be explained to some extent by the change in the demographic structure of Maçka and its plateaus, which contributed to changes in the daily life of the population of Maçka and its villages, such as changes in annual incomes, their lifestyles, decrease in transhumance and stockbreeding, decrease in the time of dwelling on the plateaus, and changes in the traditional architectural style.

Wykrywanie białka prionu w płynach ustrojowych – nowe perspektywy w diagnostyce choroby Creutzfeldta-Jakoba

Directory of Open Access Journals (Sweden)

Ewa Golańska

2013-11-01

Full Text Available Choroba Creutzfeldta-Jakoba (Creutzfeldt-Jakob disease, CJD należy do grupy chorób wywołanych przez priony, których diagnostyka nastręcza trudności ze względu na brak nieinwazyjnych metod umożliwiających przyżyciowe definitywne rozpoznanie. Rutynowe badania laboratoryjne wspomagające diagnostykę polegają na oznaczaniu obecności białka 14-3-3 w płynie mózgowo-rdzeniowym. Białko to jest jednak jedynie nieswoistym markerem rozpadu neuronów. Również badania obrazowe oraz EEG są niewystarczające do pewnego potwierdzenia rozpoznania. Obecnie duże nadzieje wiąże się z rozwojem czułych i swoistych metod wykrywania śladowych ilości nieprawidłowych konformerów białka PrPSc – markera jednoznacznie związanego z chorobami wywołanymi przez priony – znajdujących się w płynie mózgowo-rdzeniowym lub krwi chorych z CJD. W artykule omówiono opracowane w ostatnich latach metody, w których wykorzystuje się zdolność białka prionu do indukowania przekształcenia struktury przestrzennej cząsteczek PrPc w patologiczną izoformę PrPSc. Największe nadzieje na praktyczne zastosowanie budzi obecnie metoda konwersji indukowanej przez wytrząsanie (quaking-induced conversion, QuIC, oparta na amplifikacji nieprawidłowych konformerów białka prionu w warunkach in vitro z zastosowaniem oczyszczonego zrekombinowanego białka PrPc jako substratu. Omówiono zasadę metody, wyniki najnowszych badań nad jej optymalizacją oraz perspektywy wykorzystania w celach diagnostycznych i naukowych.

Molecular Weight Dependent Glucose Lowering Effect of Low Molecular Weight Chitosan Oligosaccharide (GO2KA1 on Postprandial Blood Glucose Level in SD Rats Model

Directory of Open Access Journals (Sweden)

Emmanouil Apostolidis

2013-07-01

Full Text Available This research investigated the effect of enzymatically digested low molecular weight (MW chitosan oligosaccharide on type 2 diabetes prevention. Three different chitosan oligosaccharide samples with varying MW were evaluated in vitro for inhibition of rat small intestinal α-glucosidase and porcine pancreatic α-amylase (GO2KA1; 10,000 Da. The in vitro results showed that all tested samples had similar rat α-glucosidase inhibitory and porcine α-amylase inhibitory activity. Based on these observations, we decided to further investigate the effect of all three samples at a dose of 0.1 g/kg, on reducing postprandial blood glucose levels in Sprague-Dawley (SD rat model after sucrose loading test. In the animal trial, all tested samples had postprandial blood glucose reduction effect, when compared to control, however GO2KA1 supplementation had the strongest effect. The glucose peak (Cmax for GO2KA1 and control was 152 mg/dL and 193 mg/dL, respectively. The area under the blood glucose-time curve (AUC for GO2KA1 and control was 262 h mg/dL and 305 h mg/dL, respectively. Furthermore, the time of peak plasma concentration of blood glucose (Tmax for GO2KA1 was significantly delayed (0.9 h compared to control (0.5 h. These results suggest that GO2KA1 could have a beneficial effect for blood glucose management relevant to diabetes prevention in normal and pre-diabetic individuals. The suggested mechanism of action is via inhibition of the carbohydrate hydrolysis enzyme α-glucosidase and since GO2KA1 (MW < 1000 Da had higher in vivo effect, we hypothesize that it is more readily absorbed and might exert further biological effect once it is absorbed in the blood stream, relevant to blood glucose management.

Correlation of fluvial sequences in the Mediterranean basin over the last 200 ka and their relationship to climate change

Science.gov (United States)

Macklin, M. G.; Fuller, I. C.; Lewin, J.; Maas, G. S.; Passmore, D. G.; Rose, J.; Woodward, J. C.; Black, S.; Hamlin, R. H. B.; Rowan, J. S.

2002-08-01

This paper presents a new correlation of Late and Middle Pleistocene fluvial sedimentary sequences in Greek, Libyan and Spanish river basins and evaluates river response to climate change over the Last Interglacial-Glacial Cycle. Over the past 200,000 years there have been at least 13 major alluviation episodes in the Mediterranean, although the amplitude, frequency and possibly, duration of these events varied significantly across the region. Parts of Oxygen Isotope Stage (OIS) 5 appears to have been periods of pronounced landscape change in many Mediterranean catchments with major river aggradation occurring at ˜109-111 ka (during OIS 5d) and most notably at ˜88 ka (OIS 5b/5a boundary). Other parts of OIS 5 appear to have been periods of relative fluvial inactivity. OIS 2 and 3 were both characterised by an apparent increase in the number of alluviation events, and this record of river behaviour parallels many other palaeoenvironmental records in the region which also show more frequent climate fluctuations between ˜12 and 65 ka. There is evidence for a high degree of synchrony in major river aggradation events across the Mediterranean in catchments with very different sizes, tectonic regimes and histories. Climate-related changes in catchment hydrology and vegetation cover over the last 200 ka would appear to be the primary control of large-scale (catchment wide) sedimentation over time periods of between 10 3 and 10 4 years.

Impact of climatic factors to the percentage of young in the population of brown hare (Lepus europaeus P in the Bačka district

Directory of Open Access Journals (Sweden)

Beuković Miloš

2013-01-01

Full Text Available Climatic factors, especially temperature and precipitations, greatly affect the dynamics of the hare number and population. Climatic factors directly affect the physiological and reproductive processes of both individuals and entire populations, or indirectly, through the availability of food, competition with other species, predators and other. The age structure of the hare population at the end of the period of reproduction is an important indicator of the population growth that is used for planning the level of explotation of the hare population (hunting. The rational use of the hare's population is one of the most important protection procedures and it should be well monitored and controlled by the hunting professionals. We used the average monthly temperature and the sum of monthly precipitations in the hare reproductive period (March-September during ten years (2000 - 2009, together with the percent of young in the hare population, on the territory of Bačka, for multiple regression (stepwise analysis. Results of the regression analysis show an association between the percentage of young hares and the influence of climatic factors. The average temperature and sum of precipitation in June, are the strongest predictor of the percent of young in the hare’s population in Bačka. According to the coefficient of determination (R2=0.50 climatic parameters account for 50% of variance in the percentage of young hares in Bačka. The regression correlation coefficient of all factors was R=0.70, which is on the border line between medium and high correlation.

Decay constants in soft wall AdS/QCD revisited

Energy Technology Data Exchange (ETDEWEB)

Braga, Nelson R.F., E-mail: braga@if.ufrj.br [Instituto de Física, Universidade Federal do Rio de Janeiro, Caixa Postal 68528, RJ 21941-972 (Brazil); Diles, Saulo, E-mail: smdiles@if.ufrj.br [Instituto de Física, Universidade Federal do Rio de Janeiro, Caixa Postal 68528, RJ 21941-972 (Brazil); Contreras, M.A. Martin, E-mail: ma.martin41@uniandes.edu.co [High Energy Group, Department of Physics, Universidad de los Andes, Carrera 1, No 18A-10, Bloque Ip, ZIP 111711, Bogotá (Colombia)

2016-12-10

Phenomenological AdS/QCD models, like hard wall and soft wall, provide hadronic mass spectra in reasonable consistency with experimental and (or) lattice results. These simple models are inspired in the AdS/CFT correspondence and assume that gauge/gravity duality holds in a scenario where conformal invariance is broken through the introduction of an energy scale. Another important property of hadrons: the decay constant, can also be obtained from these models. However, a consistent formulation of an AdS/QCD model that reproduces the observed behavior of decay constants of vector meson excited states is still lacking. In particular: for radially excited states of heavy vector mesons, the experimental data lead to decay constants that decrease with the radial excitation level. We show here that a modified framework of soft wall AdS/QCD involving an additional dimensionfull parameter, associated with an ultraviolet energy scale, provides decay constants decreasing with radial excitation level. In this version of the soft wall model the two point function of gauge theory operators is calculated at a finite position of the anti-de Sitter space radial coordinate.

Evaluation and Performance Analysis of 3D Printing Technique for Ka-Band Antenna Production

DEFF Research Database (Denmark)

Armendariz, Unai; Rommel, Simon; Rodríguez Páez, Juan Sebastián

2016-01-01

This paper presents the design and fabrication of 3D printed WR-28 waveguide horn antennas operating in the Ka-band frequency range between 26.5GHz and 40GHz. Three antennas are fabricated from polylactide acid filaments in conductive and non-conductive variants; the latter is covered...

Ac loss measurements on a superconducting transformer for a 25 kA superconducting rectifier

NARCIS (Netherlands)

ten Kate, Herman H.J.; Mulders, J.M.; de Reuver, J.L.; van de Klundert, L.J.M.

1984-01-01

Ac loss measurements have been performed on a superconducting transformer. The transformer is a part of a 25 kA thermally switched superconducting rectifier operating at a frequency of 0.1 Hz. The loss measurements have been automatized by means of a microcomputer sampling four relevant signals and

Attractiveness of the complex tourist offer of monasteries and villages of Fruška gora from the aspect of potential tourists

Directory of Open Access Journals (Sweden)

Škrbić Iva

2012-01-01

Full Text Available If the revival of Fruška gora villages is to be achieved and their extinction prevented, economic activity must be revived, thus enabling the existential conditions for country life. One of the alternatives is to revive the tourist village through the creation of high-quality tourism products and/or services that could be realized on the market. Merging of Fruška gora villages and monasteries may be provided with the necessary resources. However, before planning the tourist products and services, it is necessary to examine the target market demand and determine if there is potential for travel demand. If so, it would generate realistic demand after a market activation of tourism products and services. Therefore, the subject of this paper is rating of attitudes and opinions of the residents of the city of Novi Sad of the particular forms of tourism products / services that might be a part of the offer of the Fruška gora monasteries and villages in order to prove or disprove the validity of the programming of tourist products and services in Fruška gora villages and monasteries, as well as their placement on the tourist market. The study included 75 adult respondents who live in the city of Novi Sad. Survey was used, and data were analyzed by statistical analysis. The results showed that the residents of Novi Sad recognize monasteries and villages of Fruška gora as a valuable resource. There is a high level of interest in this type of tourist products and services that can result in a satisfactory real travel demand.

4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.

Science.gov (United States)

Natarajan, Jayakumar K; Alumasa, John N; Yearick, Kimberly; Ekoue-Kovi, Kekeli A; Casabianca, Leah B; de Dios, Angel C; Wolf, Christian; Roepe, Paul D

2008-06-26

Using predictions from heme-quinoline antimalarial complex structures, previous modifications of chloroquine (CQ), and hypotheses for chloroquine resistance (CQR), we synthesize and assay CQ analogues that test structure-function principles. We vary side chain length for both monoethyl and diethyl 4-N CQ derivatives. We alter the pKa of the quinolyl N by introducing alkylthio or alkoxy substituents into the 4 position and vary side chain length for these analogues. We introduce an additional titratable amino group to the side chain of 4-O analogues with promising CQR strain selectivity and increase activity while retaining selectivity. We solve atomic resolution structures for complexes formed between representative 4-N, 4-S, and 4-O derivatives vs mu-oxo dimeric heme, measure binding constants for monomeric vs dimeric heme, and quantify hemozoin (Hz) formation inhibition in vitro. The data provide additional insight for the design of CQ analogues with improved activity vs CQR malaria.

Quintessence and the cosmological constant

International Nuclear Information System (INIS)

Doran, M.; Wetterich, C.

2003-01-01

Quintessence -- the energy density of a slowly evolving scalar field -- may constitute a dynamical form of the homogeneous dark energy in the universe. We review the basic idea in the light of the cosmological constant problem. Cosmological observations or a time variation of fundamental 'constants' can distinguish quintessence from a cosmological constant

A K/Ka band radiating element for Tx/Rx phased array

KAUST Repository

Sandhu, Ali Imran; Arnieri, E.; Amendola, G.; Boccia, L.; Meniconi, E.; Ziegler, V.

2017-01-01

The paper presents a K/Ka band radiating element for TX/RX phased arrays. Dual band operations is obtained using a single radiating surface: a novel radiator is adopted and placed in a configuration in which dual band and single band elements are interleaved. The array elements are optimized to scan the beam in excess of 50° in both bands. A subarray with 49 Rx elements and 105 Tx elements was built and measured confirming the results obtained in simulations.

A K/Ka band radiating element for Tx/Rx phased array

KAUST Repository

Sandhu, Ali Imran

2017-01-20

The paper presents a K/Ka band radiating element for TX/RX phased arrays. Dual band operations is obtained using a single radiating surface: a novel radiator is adopted and placed in a configuration in which dual band and single band elements are interleaved. The array elements are optimized to scan the beam in excess of 50° in both bands. A subarray with 49 Rx elements and 105 Tx elements was built and measured confirming the results obtained in simulations.

A 40 ka high-resolution soil carbonate record from southern Utah: proxy development, paleohydrology, and paleoecology

Science.gov (United States)

Huth, T.; Cerling, T. E.; Marchetti, D. W.; Fernandez, D. P.; Mackey, G. N., III; Bowling, D. R.; Passey, B. H.

2017-12-01

Terrestrial paleoclimate records are critically important for testing hypotheses of climate dynamics and verifying climate simulations. However, unlike their oceanic counterparts, terrestrial records are short, more commonly discontinuous, and require specific geographic conditions not necessarily ideal for proposed questions (e.g., speleothem records must come from wherever a cave occurs). We instead utilize laminated soil carbonate rinds as a high resolution (100s yr) paleoclimate archive. Soil carbonate rinds can represent 10s-100s kyr, are apparently continuous over relevant timescales, maintain stratigraphic order, and are common in arid and semi-arid regions. We demonstrate the utility of this methodology at Torrey, Utah which is at the northern edge of the North American Monsoon (NAM). Sample rinds form on the bottom of large (≈1 m) boulders. The rinds are 0.5-2 cm thick and have visually and microscopically identifiable stratigraphy. Radiocarbon dates are in order and suggest a nearly constant growth rate from ≈40 ka to 3 ka, when the record ends. However, the pendants have significant pore space, so secondary carbonate has the potential to bias sample ages to be too young by 100s-1000s years. Precise sampling may be able to mitigate this bias. In spite of the potential secondary carbonate bias, δ13C and δ18O analyses show trends consistent with regional records. Secondary carbonate is therefore a concern, but apparently does not overpower the primary isotopic signals. A calibration study identified soil carbonate formation during the peak growing season (i.e., JAS, during the NAM), so we interpret our records as summer signals modulated by soil `memory' effects. The δ18O record has low variability (±0.5 ‰) but mimics regional NAM records, suggesting similar climate drivers as far north as Utah. The δ13C record shows some correlation with δ18O, which is reasonable given that the strength of the NAM can drive ecologic responses. However, the data

Theoretical prediction of pKa in methanol: testing SM8 and SMD models for carboxylic acids, phenols, and amines.

Science.gov (United States)

Miguel, Elizabeth L M; Silva, Poliana L; Pliego, Josefredo R

2014-05-29

Methanol is a widely used solvent for chemical reactions and has solvation properties similar to those of water. However, the performance of continuum solvation models in this solvent has not been tested yet. In this report, we have investigated the performance of the SM8 and SMD models for pKa prediction of 26 carboxylic acids, 24 phenols, and 23 amines in methanol. The gas phase contribution was included at the X3LYP/TZVPP+diff//X3LYP/DZV+P(d) level. Using the proton exchange reaction with acetic acid, phenol, and ammonia as reference species leads to RMS error in the range of 1.4 to 3.6 pKa units. This finding suggests that the performance of the continuum models for methanol is similar to that found for aqueous solvent. Application of simple empirical correction through a linear equation leads to accurate pKa prediction, with uncertainty less than 0.8 units with the SM8 method. Testing with the less expensive PBE1PBE/6-311+G** method results in a slight improvement in the results.

New tests on the 40 kA Nb3Sn CEA conductor for ITER applications

International Nuclear Information System (INIS)

Duchateau, J.L.; Bessette, D.; Katheder, H.

1994-01-01

New tests have been performed on the 40 kA CEA Nb 3 Sn conductor in the Sultan III facility. The aim of these tests is to obtain key experimental data on the behaviour of Nb 3 Sn conductors for fusion applications under high field and large transport current. The 40 kA Nb 3 Sn CEA conductor has a shape and an internal arrangement of the superconducting wires which is very similar to the ITER conductors. The level of the ac losses experienced by these conductors under varying fields influences deeply their design. The basic experiment consists of producing field pulses on the conductor by means of a coil installed in the bore of the Sultan magnet and recording the integrated voltage obtained on pick-up coils placed on the conductor as a function of time. (author) 4 refs.; 5 figs.; 2 tabs

A Study of Acid-Base Equilibria in Acetonitrile Systems of 2-Halo(Cl,Br,I-4-nitropicoline(3,5,6 N-oxides

Directory of Open Access Journals (Sweden)

Lech Chmurzynski

1999-03-01

Full Text Available An attempt has been made to determine potentiometrically (1 acid dissociation constants of cations obtained by protonation of nine trisubstituted pyridine N-oxides, namely 2-halo(Cl, Br and I-4-nitropicoline N-oxides with the methyl group at positions 3, 5, and 6, as well as (2 the cationic homoconjugation constants of these cationic acids with conjugated N-oxides in acetonitrile. On the basis of the substitution effect, variations of the acid dissociation constants of the trisubstituted pyridine N-oxide cations are discussed. The determined pKa values of the protonated 2-halo-4-nitropicoline N-oxides are compared with the previously determined equilibrium constants of the cationic acids conjugated with the mono- and disubstituted pyridine N-oxides in acetonitrile. Further, based on the pKa values of the protonated 2-halo-4-nitropicoline N-oxides in acetonitrile, supplemented with correlations between pKa’s of the protonated mono- and disubstituted pyridine N-oxides in acetonitrile and water, the pKa's of the acids conjugated with the trisubstituted N-oxides studied in aqueous solutions have been estimated. Moreover, it has been concluded that the cationic homoconjugation constants cannot be determined by potentiometric titration in acetonitrile solutions of the 2-halo-4-nitropicoline N-oxide systems.

Lambda-guided calculation method (LGC method) for xenon/CT CBF

Energy Technology Data Exchange (ETDEWEB)

Sase, Shigeru [Anzai Medical Co., Ltd., Tokyo (Japan); Honda, Mitsuru; Kushida, Tsuyoshi; Seiki, Yoshikatsu; Machida, Keiichi; Shibata, Iekado [Toho Univ., Tokyo (Japan). School of Medicine

2001-12-01

A quantitative CBF calculation method for xenon/CT was developed by logically estimating time-course change rate (rate constant) of arterial xenon concentration from that of end-tidal xenon concentration. A single factor ({gamma}) was introduced to correlate the end-tidal rate constant (Ke) with the arterial rate constant (Ka) in a simplified equation. This factor ({gamma}) is thought to reflect the diffusing capacity of the lung for xenon. When an appropriate value is given to {gamma}, it is possible to calculate the arterial rate constant (Calculated Ka) from Ke. To determine {gamma} for each xenon/CT CBF examination, a procedure was established which utilizes the characteristics of white matter lambda; lambda refers to xenon brain-blood partition coefficient. Xenon/CT studies were performed on four healthy volunteers. Hemispheric CBF values (47.0{+-}9.0 ml/100 g/min) with use of Calculated Ka were close to the reported normative values. For a 27-year-old healthy man, the rate constant for the common carotid artery was successfully measured and nearly equal to Calculated Ka. The authors conclude the method proposed in this work, lambda-guided calculation method, could make xenon/CT CBF substantially reliable and quantitative by effective use of end-tidal xenon. (author)

Lambda-guided calculation method (LGC method) for xenon/CT CBF

International Nuclear Information System (INIS)

Sase, Shigeru; Honda, Mitsuru; Kushida, Tsuyoshi; Seiki, Yoshikatsu; Machida, Keiichi; Shibata, Iekado

2001-01-01

A quantitative CBF calculation method for xenon/CT was developed by logically estimating time-course change rate (rate constant) of arterial xenon concentration from that of end-tidal xenon concentration. A single factor (γ) was introduced to correlate the end-tidal rate constant (Ke) with the arterial rate constant (Ka) in a simplified equation. This factor (γ) is thought to reflect the diffusing capacity of the lung for xenon. When an appropriate value is given to γ, it is possible to calculate the arterial rate constant (Calculated Ka) from Ke. To determine γ for each xenon/CT CBF examination, a procedure was established which utilizes the characteristics of white matter lambda; lambda refers to xenon brain-blood partition coefficient. Xenon/CT studies were performed on four healthy volunteers. Hemispheric CBF values (47.0±9.0 ml/100 g/min) with use of Calculated Ka were close to the reported normative values. For a 27-year-old healthy man, the rate constant for the common carotid artery was successfully measured and nearly equal to Calculated Ka. The authors conclude the method proposed in this work, lambda-guided calculation method, could make xenon/CT CBF substantially reliable and quantitative by effective use of end-tidal xenon. (author)

The paleoclimatic events and cause in the Okinawa Trough during 50 kaBP

Institute of Scientific and Technical Information of China (English)

无

2001-01-01

Planktonic foraminiferal d18O record for core DGKS9603 from the Okinawa Trough shows a series of climatic fluctuations and sudden cooling events in short time scale during 50 kaBP, which appear to correlate closely to the Younger Dryas and Heinrich events H1-5 recorded in Chine-se loess, the South China Sea, the North Atlantic cores and the Greenland ice cores. Three polarity reversal events, cor-relating to Gothenburg, Mungo and Laschamp events, ap-proximately correspond to Heinrich events H1, H3 and H5 respectively, which could be a cause of global climate changes. The d18O curve of the Okinawa Trough is well asso-ciated with the grain size record of the Lijiayuan loess profile in northwestern China and is somewhat different from the climate fluctuations documented in the Greenland ice cores. These correlation results indicate that regional factors play an important role in controlling the climate changes in the East Asia, and the East Asian Monsoon could be the promi-nent regional controlling factor.

Cultural Factors Associated with Breast and Cervical Cancer Screening in Korean American Women in the US: An Integrative Literature Review

Directory of Open Access Journals (Sweden)

Shin-Young Lee, PhD

2015-06-01

Conclusions: Theories focusing on interpersonal relationships and standardized, reliable, and valid instruments to measure cultural concepts are needed to breast and cervical cancer screening research in KA women. Traditional cultural factors associated with cancer screening should be considered for practical implications and future research with KA women.

Development of Monopole Interaction Models for Ionic Compounds. Part I: Estimation of Aqueous Henry’s Law Constants for Ions and Gas Phase pKa Values for Acidic Compounds

Science.gov (United States)

The SPARC (SPARC Performs Automated Reasoning in Chemistry) physicochemical mechanistic models for neutral compounds have been extended to estimate Henry’s Law Constant (HLC) for charged species by incorporating ionic electrostatic interaction models. Combinations of absolute aq...

Pre-eruptive conditions of dacitic magma erupted during the 21.7 ka Plinian event at Nevado de Toluca volcano, Central Mexico

Science.gov (United States)

Arce, J. L.; Gardner, J. E.; Macías, J. L.

2013-01-01

The Nevado de Toluca volcano in Central Mexico has been active over the last ca. 42 ka, during which tens of km3 of pyroclastic material were erupted and two important Plinian-type eruptions occurred at ca. 21.7 ka (Lower Toluca Pumice: LTP) and ca. 10.5 ka (Upper Toluca Pumice: UTP). Samples from both the LTP and UTP contain plagioclase, amphibole, iron-titanium oxides, and minor anhedral biotite, set in a vesicular, rhyolitic, glassy matrix. In addition, UTP dacites contain orthopyroxene. Analysis of melt inclusions in plagioclase phenocrysts yields H2O contents of 2-3.5 wt.% for LTP and 1.3-3.6 wt.% for UTP samples. Ilmenite-ulvospinel geothermometry yields an average temperature of ~ 868 °C for the LTP magma (hotter than the UTP magma, ~ 842 °C; Arce et al., 2006), whereas amphibole-plagioclase geothermometry yields a temperature of 825-859 °C for the LTP magma. Water-saturated experiments using LTP dacite suggest that: (i) amphibole is stable above 100 MPa and below 900 °C; (ii) plagioclase crystallizes below 250-100 MPa at temperatures of 850-900 °C; and (iii) pyroxene is stable only below pressures of 200-100 MPa and temperatures of 825-900 °C. Comparison of natural and experimental data suggests that the LTP dacitic magma was stored at 150-200 MPa (5.8-7.7 km below the volcano summit). No differences in pressure found between 21.7 ka and 10.5 ka suggest that these two magmas were stored at similar depths. Orthopyroxene produced in lower temperature LTP experiments is compositionally different to those found in UTP natural samples, suggesting that they originated in two different magma batches. Whole-rock chemistry, petrographic features, and mineral compositions suggest that magma mixing was responsible for the generation of the dacitic Plinian LTP eruption.

Cosmological constants and variations

International Nuclear Information System (INIS)

Barrow, John D

2005-01-01

We review properties of theories for the variation of the gravitation and fine structure 'constants'. We highlight some general features of the cosmological models that exist in these theories with reference to recent quasar data that is consistent with time-variation in the fine structure 'constant' since a redshift of 3.5. The behaviour of a simple class of varying alpha cosmologies is outlined in the light of all the observational constraints. We also discuss some of the consequences of varying 'constants' for oscillating universes and show by means of exact solutions that they appear to evolve monotonically in time even though the scale factor of the universe oscillates

Determination of pKa and the corresponding structures of quinclorac using combined experimental and theoretical approaches

Science.gov (United States)

Song, Dean; Sun, Huiqing; Jiang, Xiaohua; Kong, Fanyu; Qiang, Zhimin; Zhang, Aiqian; Liu, Huijuan; Qu, Jiuhui

2018-01-01

As an emerging environmental contaminant, the herbicide quinclorac has attracted much attention in recent years. However, a very fundamental issue, the acid dissociation of quinclorac has not yet to be studied in detail. Herein, the pKa value and the corresponding structures of quinclorac were systematically investigated using combined experimental and theoretical approaches. The experimental pKa of quinclorac was determined by the spectrophotometric method to be 2.65 at 25 °C with ionic strength of 0.05 M, and was corrected to be 2.56 at ionic strength of zero. The molecular structures of quinclorac were then located by employing the DFT calculation. The anionic quinclorac was directly located with the carboxylic group perpendicular to the aromatic ring, while neutral quinclorac was found to be the equivalent twin structures. The result was further confirmed by analyzing the UV/Vis and MS-MS2 spectra from both experimental and theoretical viewpoints. By employing the QSPR approach, the theoretical pKa of QCR was determined to be 2.50, which is excellent agreement with the experimental result obtained herein. The protonation of QCR at the carboxylic group instead of the quinoline structure was attributed to the weak electronegative property of nitrogen atom induced by the electron-withdrawing groups. It is anticipated that this work could not only help in gaining a deep insight into the acid dissociation of quinclorac but also offering the key information on its reaction and interaction with others.

Evidence for an Elevated Aspartate pKa in the Active Site of Human Aromatase*

Science.gov (United States)

Di Nardo, Giovanna; Breitner, Maximilian; Bandino, Andrea; Ghosh, Debashis; Jennings, Gareth K.; Hackett, John C.; Gilardi, Gianfranco

2015-01-01

Aromatase (CYP19A1), the enzyme that converts androgens to estrogens, is of significant mechanistic and therapeutic interest. Crystal structures and computational studies of this enzyme shed light on the critical role of Asp309 in substrate binding and catalysis. These studies predicted an elevated pKa for Asp309 and proposed that protonation of this residue was required for function. In this study, UV-visible absorption, circular dichroism, resonance Raman spectroscopy, and enzyme kinetics were used to study the impact of pH on aromatase structure and androstenedione binding. Spectroscopic studies demonstrate that androstenedione binding is pH-dependent, whereas, in contrast, the D309N mutant retains its ability to bind to androstenedione across the entire pH range studied. Neither pH nor mutation perturbed the secondary structure or heme environment. The origin of the observed pH dependence was further narrowed to the protonation equilibria of Asp309 with a parallel set of spectroscopic studies using exemestane and anastrozole. Because exemestane interacts with Asp309 based on its co-crystal structure with the enzyme, its binding is pH-dependent. Aromatase binding to anastrozole is pH-independent, consistent with the hypothesis that this ligand exploits a distinct set of interactions in the active site. In summary, we assign the apparent pKa of 8.2 observed for androstenedione binding to the side chain of Asp309. To our knowledge, this work represents the first experimental assignment of a pKa value to a residue in a cytochrome P450. This value is in agreement with theoretical calculations (7.7–8.1) despite the reliance of the computational methods on the conformational snapshots provided by crystal structures. PMID:25425647

Thermodynamics of de Sitter black holes: Thermal cosmological constant

International Nuclear Information System (INIS)

Sekiwa, Y.

2006-01-01

We study the thermodynamic properties associated with the black hole event horizon and the cosmological horizon for black hole solutions in asymptotically de Sitter spacetimes. We examine thermodynamics of these horizons on the basis of the conserved charges according to Teitelboim's method. In particular, we have succeeded in deriving the generalized Smarr formula among thermodynamical quantities in a simple and natural way. We then show that cosmological constant must decrease when one takes into account the quantum effect. These observations have been obtained if and only if the cosmological constant plays the role of a thermodynamical state variable. We also touch upon the relation between inflation of our universe and a phase transition of black holes

The Fine Structure Constant

Indian Academy of Sciences (India)

IAS Admin

The article discusses the importance of the fine structure constant in quantum mechanics, along with the brief history of how it emerged. Al- though Sommerfelds idea of elliptical orbits has been replaced by wave mechanics, the fine struc- ture constant he introduced has remained as an important parameter in the field of ...

Detailed design of a 13 kA 13 kV dc solid-state turn-off switch

International Nuclear Information System (INIS)

Praeg, W.F.

1985-01-01

An experimental facility for the study of electromagnetic effects in the First Wall-Blanket-shield (FWBS) systems of fusion reactors has been constructed at Argonne National Laboratory (ANL). In a test volume of 0.76 m 3 , a vertical, pulsed 5 kG dipole field (B -1 ) is perpendicular to a 10 kG solenoid field. Power supplies of 2.75 MW at 550 V dc and 5.5 MW at 550 V dc and a solid-state switch rated at 13 kA and 13 kV (169 MW) control the pulsed magnetic fields. The total stored energy in the coils is 2.6 MJ. This paper describes the design and construction features of the solid-state switching circuit which turns off a dc of 13 kA in approximately 82 μs and holds off voltages of < 13 kV

Cosmological constant from a deformation of the Wheeler–DeWitt equation

International Nuclear Information System (INIS)

Garattini, Remo; Faizal, Mir

2016-01-01

In this paper, we consider the Wheeler–DeWitt equation modified by a deformation of the second quantized canonical commutation relations. Such modified commutation relations are induced by a Generalized Uncertainty Principle. Since the Wheeler–DeWitt equation can be related to a Sturm–Liouville problem where the associated eigenvalue can be interpreted as the cosmological constant, it is possible to explicitly relate such an eigenvalue to the deformation parameter of the corresponding Wheeler–DeWitt equation. The analysis is performed in a Mini-Superspace approach where the scale factor appears as the only degree of freedom. The deformation of the Wheeler–DeWitt equation gives rise to a Cosmological Constant even in absence of matter fields. As a Cosmological Constant cannot exist in absence of the matter fields in the undeformed Mini-Superspace approach, so the existence of a non-vanishing Cosmological Constant is a direct consequence of the deformation by the Generalized Uncertainty Principle. In fact, we are able to demonstrate that a non-vanishing Cosmological Constant exists even in the deformed flat space. We also discuss the consequences of this deformation on the big bang singularity.

Cosmological constant from a deformation of the Wheeler–DeWitt equation

Directory of Open Access Journals (Sweden)

Remo Garattini

2016-04-01

Full Text Available In this paper, we consider the Wheeler–DeWitt equation modified by a deformation of the second quantized canonical commutation relations. Such modified commutation relations are induced by a Generalized Uncertainty Principle. Since the Wheeler–DeWitt equation can be related to a Sturm–Liouville problem where the associated eigenvalue can be interpreted as the cosmological constant, it is possible to explicitly relate such an eigenvalue to the deformation parameter of the corresponding Wheeler–DeWitt equation. The analysis is performed in a Mini-Superspace approach where the scale factor appears as the only degree of freedom. The deformation of the Wheeler–DeWitt equation gives rise to a Cosmological Constant even in absence of matter fields. As a Cosmological Constant cannot exist in absence of the matter fields in the undeformed Mini-Superspace approach, so the existence of a non-vanishing Cosmological Constant is a direct consequence of the deformation by the Generalized Uncertainty Principle. In fact, we are able to demonstrate that a non-vanishing Cosmological Constant exists even in the deformed flat space. We also discuss the consequences of this deformation on the big bang singularity.

Density functional theory prediction of pKa for carboxylated single-wall carbon nanotubes and graphene

Science.gov (United States)

Li, Hao; Fu, Aiping; Xue, Xuyan; Guo, Fengna; Huai, Wenbo; Chu, Tianshu; Wang, Zonghua

2017-06-01

Density functional calculations have been performed to investigate the acidities for the carboxylated single-wall carbon nanotubes and graphene. The pKa values for different COOH-functionalized models with varying lengths, diameters and chirality of nanotubes and with different edges of graphene were predicted using the SMD/M05-2X/6-31G* method combined with two universal thermodynamic cycles. The effects of following factors, such as, the functionalized position of carboxyl group, the Stone-Wales and single vacancy defects, on the acidity of the functionalized nanotube and graphene have also been evaluated. The deprotonated species have undergone decarboxylation when the hybridization mode of the carbon atom at the functionalization site changed from sp2 to sp3 both for the tube and graphene. The knowledge of the pKa values of the carboxylated nanotube and graphene could be of great help for the understanding of the nanocarbon materials in many diverse areas, including environmental protection, catalysis, electrochemistry and biochemistry.

20180318 - Prediction Of pKa From Chemical Structure Using Free And Open-Source Tools (ACS Spring)

Science.gov (United States)

The ionization state of a chemical, reflected in pKa values, affects lipophilicity, solubility, protein binding and the ability of a chemical to cross the plasma membrane. These properties govern the pharmacokinetic parameters such as absorption, distribution, metabolism, excreti...

Tachyon constant-roll inflation

Science.gov (United States)

Mohammadi, A.; Saaidi, Kh.; Golanbari, T.

2018-04-01

The constant-roll inflation is studied where the inflaton is taken as a tachyon field. Based on this approach, the second slow-roll parameter is taken as a constant which leads to a differential equation for the Hubble parameter. Finding an exact solution for the Hubble parameter is difficult and leads us to a numerical solution for the Hubble parameter. On the other hand, since in this formalism the slow-roll parameter η is constant and could not be assumed to be necessarily small, the perturbation parameters should be reconsidered again which, in turn, results in new terms appearing in the amplitude of scalar perturbations and the scalar spectral index. Utilizing the numerical solution for the Hubble parameter, we estimate the perturbation parameter at the horizon exit time and compare it with observational data. The results show that, for specific values of the constant parameter η , we could have an almost scale-invariant amplitude of scalar perturbations. Finally, the attractor behavior for the solution of the model is presented, and we determine that the feature could be properly satisfied.

Preliminary paleomagnetic and rock magnetic results from 17 to 22 ka sediment of Jeju Island, Korea: Geomagnetic excursional behavior or rock magnetic anomalies?

Science.gov (United States)

Ahn, Hyeon-Seon; Sohn, Young Kwan; Lee, Jin-Young; Kim, Jin Cheul

2018-05-01

Paleomagnetic and rock magnetic investigations were performed on a 64-cm-thick section of nonmarine unconsolidated muddy sediment from the Gosan Formation on Jeju Island, Korea. This sediment was recently dated to have been deposited between 22 and 17 kyr BP calibrated, with a sedimentation rate of 13-25 cm/kyr, based on many radiocarbon ages. Interestingly, stepwise alternating field (AF) demagnetization revealed characteristic natural remanent magnetizations with anomalous directions, manifested by marked deviations from the direction of today's axial dipole field, for some separate depth levels. On the other hand, stepwise thermal (TH) demagnetization showed more complex behavior, resulting in the identification of multiple remanence components. For all TH-treated specimens, consistently two different components are predominant: a low-temperature component unblocked below 240-320 °C entirely having normal-polarity apparently within the secular variation range of the Brunhes Chron, and a high-temperature component with unblocking temperatures (Tubs) between 240-320 and 520-580 °C that have anomalous directions, concentrated in the 13-34-cm-depth interval ( 17-19 ka in inferred age) and possibly below 53 cm depth (before 20 ka). Rock magnetic results also infer the dominance of low-coercivity magnetic particles having 300 and 580 °C Curie temperature as remanence carriers, suggestive of (titano)maghemite and/or Ti-rich titanomagnetite and magnetite (or Ti-poor titanomagnetite), respectively. A noteworthy finding is that AF demagnetizations in this study often lead to incomplete separation of the two remanence components possibly due to their strongly overlapping AF spectra. The unusual directions do not appear to result from self-reversal remanences. Then, one interpretation is that the low-temperature components are attributable to post-depositional chemical remanences, associated possibly with the later formation of the mineral phase having Tub 300 �

The cosmological constant, branes and non-geometry

International Nuclear Information System (INIS)

Gautason, Fridhrik Freyr

2014-01-01

when geometric backgrounds with non-trivial NSNS flux are subject to a chain of T-dualities. Finally we argue that using S-duality also leads to exotic branes and modified Bianchi identities for associated non-geometric RR flux. Some non-geometric flux compactifications have been shown to give rise to a positive cosmological constant from the dimensionally reduced point of view. The study of exotic branes is a step towards complete understanding of non-geometric fluxes from a ten-dimensional point of view.

submitter Manufacture and Test of ITER 10-kA HTSCL Prototypes

CERN Document Server

Zhou, Tingzhi; Liu, Chenglian; Lu, Kun; Ran, Qingxiang; Song, Yuntao; Niu, Erwu; Bauer, Pierre; Devred, Arnaud; Lee, Seungje; Taylor, Thomas; Yang, Yifeng

2016-01-01

To carry current for the ITER correction coils, the 10-kA high-temperature superconducting current leads studied here are designed. Current leads provide the transition from 4.5-K low temperature to room temperature. This paper summarizes the major design features of the prototypes, which is followed by a discussion of the manufacturing and testing. The test results approved their excellent performance on low joint resistance and long loss-of-flow accident time. The overheating time, mass flow, and heat loads to 5-K ends also reached the expectation.

Varying Constants, Gravitation and Cosmology

Directory of Open Access Journals (Sweden)

Jean-Philippe Uzan

2011-03-01

Full Text Available Fundamental constants are a cornerstone of our physical laws. Any constant varying in space and/or time would reflect the existence of an almost massless field that couples to matter. This will induce a violation of the universality of free fall. Thus, it is of utmost importance for our understanding of gravity and of the domain of validity of general relativity to test for their constancy. We detail the relations between the constants, the tests of the local position invariance and of the universality of free fall. We then review the main experimental and observational constraints that have been obtained from atomic clocks, the Oklo phenomenon, solar system observations, meteorite dating, quasar absorption spectra, stellar physics, pulsar timing, the cosmic microwave background and big bang nucleosynthesis. At each step we describe the basics of each system, its dependence with respect to the constants, the known systematic effects and the most recent constraints that have been obtained. We then describe the main theoretical frameworks in which the low-energy constants may actually be varying and we focus on the unification mechanisms and the relations between the variation of different constants. To finish, we discuss the more speculative possibility of understanding their numerical values and the apparent fine-tuning that they confront us with.

Nuclear constants

International Nuclear Information System (INIS)

Foos, J.

1999-01-01

This paper is written in two tables. The first one describes the different particles (bosons and fermions). The second one gives the isotopes nuclear constants of the different elements, for Z = 1 to 56. (A.L.B.)

Nuclear constants

International Nuclear Information System (INIS)

Foos, J.

2000-01-01

This paper is written in two tables. The first one describes the different particles (bosons and fermions). The second one gives the isotopes nuclear constants of the different elements, for Z = 56 to 68. (A.L.B.)

Nuclear constants

International Nuclear Information System (INIS)

Foos, J.

1999-01-01

This paper is written in two tables. The first one describes the different particles (bosons and fermions). The second one gives the isotopes nuclear constants of the different elements, for Z = 56 to 68. (A.L.B.)

Electrochemistry of 2-dimethylaminoethanethiol SAM on gold electrode: Interaction with SWCNT-poly(m-aminobenzene sulphonic acid), electric field-induced protonation-deprotonation, and surface pKa

CSIR Research Space (South Africa)

Pillay, J

2009-06-01

Full Text Available -called electric field induced protonation-deprotonation process, hitherto observed for the -COOH terminated SAMs, is also observed for the -N(H)+(CH3)2 terminated. The surface pKa of DMAET was estimated as 7.6, smaller than its solution pKa of 10.8. It is also...

Reconstruction of past climate variability in SE Spain between 14 and 8 ka

Science.gov (United States)

Budsky, Alexander; Scholz, Denis; Mertz-Kraus, Regina; Christoph, Spötl; Gibert, Luis; Jochum, Klaus Peter; Andreae, Meinrat O.

2016-04-01

In comparison to the large climatic oscillations during the Pleistocene, Holocene climate only underwent minor changes. Nevertheless, cyclic climate changes also occurred during the Holocene. The Bond events, represented by the presence of cold, ice-bearing waters from the north of Iceland as far south as the latitude of Britain, occurred at a cyclicity of about 1500 a and were particularly pronounced during the Early Holocene. However, their climatic impact on the terrestrial realm was not consistent over Europe, in particular with respect to changes in precipitation. Here we present a precisely dated high-resolution flowstone record from Cueva Victoria, SE Spain, a site well suited to study the competing influence of the Atlantic and Mediterranean Sea on the southern Iberian Peninsula. We sampled several flowstones with a thickness of up to 60 cm. 230Th/U-dating has shown that these deposits mainly formed during relatively warm climate intervals of the Middle and Late Pleistocene, i.e. interglacials and interstadials (Budsky et al., 2015; Gibert et al., 2016). Here we focus on a short (11 cm) flowstone sequence from the Holocene with a high temporal resolution (centennial for stable isotopes and annual for trace elements). The flowstone grew between 14 and ca. 8 ka b2k. The decreasing trend of the δ18O and δ13C values as well as of several trace elements between 12 and 11 ka b2k reflects an increase in temperature and precipitation at the beginning of the Holocene. In particular, Sr and Mg show a trend towards low and stable values. Subsequently, from 10.5 to 8 ka b2k, the δ13C values show a high variability (-11 to -4), whereas the δ18O values are rather stable (between -6 and -7). Maxima in δ13C are interpreted as drier conditions in response to Bond events. These events possibly led to a change of the atmospheric circulation, affecting the vegetation in SE Spain, which evolved towards an open C3 vegetation at ca. 8 ka b2k concomitant with drier conditions

Determination of protonation constants of hydroquinone and stability constants of Th(IV) hydroquinone complex

International Nuclear Information System (INIS)

Sawant, R.M.; Ramakumar, K.L.; Sharma, R.S.

2003-01-01

Protonation constants of hydroquinone and stability constants of thorium hydroquinone complexes were determined in 1 M NaClO 4 medium at 25 ± 0.5 degC, by varying concentration of thorium, using pH titration technique. Protonation constants of hydroquinone (β 1H = [HQ]/[H][Q] and β 2H = [H 2 Q]/[H] 2 [Q]) were found to be β 1H = 11.404 ± 0.014 and β 2H = 21.402 ± 0.012. The analysis of titration data of thorium-hydroquinone system appears to indicate the formation of species Th(H 2 Q) 3 (OH) and Th(H 2 O) 4 (OH). Equilibrium constants obtained for these species are -log β 13-I = 48.51 ± 0.67 and -log β 14-1 64.86 ± 1.25 respectively which are not reported in the literature. (author)

Nuclear constants

International Nuclear Information System (INIS)

Foos, J.

1998-01-01

This paper is made of two tables. The first table describes the different particles (bosons and fermions) while the second one gives the nuclear constants of isotopes from the different elements with Z = 1 to 25. (J.S.)

Beringian Megafaunal Extinctions at ~37 ka B.P.: Do Micrometeorites Embedded in Fossil Tusks and Skulls Indicate an Extraterrestial Precursor to the Younger Dryas Event?

Science.gov (United States)

Hagstrum, J. T.; Firestone, R. B.; West, A.

2009-12-01

Studies of Late Pleistocene megafaunal fossils and their ancient DNA from Beringia (eastern Siberia, Alaska, and the emerged Bering Strait) indicate sharp declines in steppe bison population diversity and horse body size, extinction of the Alaskan wild ass, and local extinctions of brown bear and woolly mammoth genetic lines beginning at about 37 ka B.P. Beringia is also well known for its remarkably preserved Late Pleistocene frozen animal mummies. 14C ages of these mummies are bimodally distributed, having peaks coincident with the earlier ~37 ka B.P., and ~13 ka B.P. Younger Dryas, onset extinction events. Associated with the ~37 ka B.P. event are, for example, the Berezovka mammoth, headless Selerikan horse, steppe bison “Blue Babe”, and baby mammoths “Dima” and “Lyuba”. Analyses of these and other mummies indicate that they died instantly, in mostly healthy condition, with gut contents and high fat reserves indicative of a late summer to autumn season. An assortment of uneaten limbs and other body parts from a variety of species have also been found. Uniformitarian death scenarios inadequately account for the lack of evidence of normal predation and scavenging. Extensive internal injuries (e.g. large bone fractures, hemorrhaging) and apparent rapid burial of the mummies also indicate that something truly unusual happened at the time of these extinction events. We have discovered what appear to be micrometeorites embedded in seven Alaskan mammoth tusks and a Siberian bison skull acquired from commercial sources. 14C ages for five of these fossils have a weighted mean age of 33 ± 2 ka B.P. Laser ablation ICP-MS and XRF analyses of the particles indicate high Fe contents with compositions enriched in Ni and depleted in Ti, similar to Fe meteorites and unlike any natural terrestrial sources. Microprobe analyses of a Fe-Ni sulfide grain from tusk 2 also show that it contains between 3 and 20 weight percent Ni. SEM images and XRF analyses of a bison

Muusikamaailm : "Passioon 2000" Stuttgardis. Ojai festivalilt. Boulez dirigeerib ka Edinburghis. Placido Domingo Helsingis / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2000-01-01

Stuttgardi Rahvusvahelisel Bachi Akadeemia korraldataval Euroopa muusikafestivalil ettekandele tulevatest "tänapäevastest passioonidest". Ojai muusikafestivalist Jaapanis. P. Boulezi 75. sünnipäevale pühendatud kontserdisari "Boulez 2000" jõudis ka Edinburghi festivalile. P. Domingo kontserdist Helsingi olümpiastaadionil, K. Mattila kontserdist Helsingi Areenal

Europium (III) and americium (III) stability constants with humic acid

International Nuclear Information System (INIS)

Torres, R.A.; Choppin, G.R.

1984-01-01

The stability constants for tracer concentrations of Eu(III) and Am(III) complexes with a humic acid extracted from a lake-bottom sediment were measured using a solvent extraction system. The organic extractant was di(2-ethylhexyl)-phosphoric acid in toluene while the humate aqueous phase had a constant ionic strength of 0.1 M (NaClO 4 ). Aqueous humic acid concentrations were monitored by measuring uv-visible absorbances at approx.= 380 nm. The total carboxylate capacity of the humic acid was determined by direct potentiometric titration to be 3.86 +- 0.03 meq/g. The humic acid displayed typical characteristics of a polyelectrolyte - the apparent pKsub(a), as well as the calculated metal ion stability constants increased as the degree of ionization (α) increased. The binding data required a fit of two stability constants, β 1 and β 2 , such that for Eu, log β 1 = 8.86 α + 4.39, log β 2 = 3.55 α + 11.06 while for Am, log β 1 = 10.58 α + 3.84, log β 2 = 5.32 α + 10.42. With hydroxide, carbonate, and humate as competing ligands, the humate complex associated with the β 1 constant is calculated to be the dominant species for the trivalent actinides and lanthanides under conditions present in natural waters. (orig.)

A Stopped-Flow Kinetics Experiment for Advanced Undergraduate Laboratories: Formation of Iron(III) Thiocyannate

Science.gov (United States)

Clark, Charles R.

1997-10-01

A series of 15 stopped-flow kinetic experiments relating to the formation of iron(III)- thiocyanate at 25.0 °C and I = 1.0 M (NaClO4) is described. A methodology is given whereby solution preparation and data collection are able to be carried out within the time scale of a single laboratory period (3-4 h). Kinetic data are obtained using constant [SCN-], and at three H+ concentrations (0.10, 0.20, 0.30 M) for varying concentrations of Fe3+ (ca. 0.0025 - 0.020 M). Rate data (450 nm) are consistent with rate laws for the forward and reverse reactions: kf = (k1 + k2Ka1/[H+])[Fe3+] and kr = k-1 + k-2Ka2/[H+] respectively, with k1,k-1 corresponding to the rate constants for formation and decay of FeSCN2+, k2, k-2 to the rate constants for formation and decay of the FeSCN(OH)+ ion and Ka1,Ka2 to the acid dissociation constants (coordinated OH2 ionization) of Fe3+ and FeSCN2+. Using literature values for the latter two quantities ( Ka1 = 2.04 x 10-3 M, Ka2 = 6.5 x 10-5 M) allows values for the four rate constants to be obtained. A typical data set is analyzed to give k1 = 109(10) M-1s-1, k-1 = 0.79(0.10) s-1, k2= 8020(800) M-1s-1, k-2 = 2630(230) s-1. Absorbance change data for reaction (DeltaA) follow the expression: DeltaA = Alim.Kf.[Fe3+]/(1 + Kf.[Fe3+]), with Alim corresponding to the absorbance of fully formed FeSCN2+ (i.e. free SCN- absent) and Kf to the formation constant of this complex (value in the example 112(5) M-1, c.f. 138(29) M-1 from the kinetic data).

Ionisation constants of radiopharmaceuticals by HPLC

Energy Technology Data Exchange (ETDEWEB)

Stylli, C.G.; Theobald, A.E.

It has long been recognised that the pKsub(a) of drugs and radiopharmaceuticals is an important determinant of their biological distribution. In this study an HPLC method for pKa measurement has been developed for radiotracers. It has been validated with several amines and used to estimate the pKsub(a) values of some Tc-99m PnAO complexes by observing the change in chromatographic retention with change in mobile phase pH. The pKsub(a) values were estimated from the data by three methods: derivative analysis, quadratic regression, and the Henderson - Hasselbalch equation.

Ionisation constants of radiopharmaceuticals by HPLC

International Nuclear Information System (INIS)

Stylli, C.G.; Theobald, A.E.

1986-01-01

It has long been recognised that the pKsub(a) of drugs and radiopharmaceuticals is an important determinant of their biological distribution. In this study an HPLC method for pKa measurement has been developed for radiotracers. It has been validated with several amines and used to estimate the pKsub(a) values of some Tc-99m PnAO complexes by observing the change in chromatographic retention with change in mobile phase pH. The pKsub(a) values were estimated from the data by three methods: derivative analysis, quadratic regression, and the Henderson - Hasselbalch equation. (author)

Major dust events in Europe during marine isotope stage 5 (130–74 ka: a climatic interpretation of the "markers"

Directory of Open Access Journals (Sweden)

D.-D. Rousseau

2013-09-01

Full Text Available At present, major dust storms are occurring at mid-latitudes in the Middle East and Asia, as well as at low latitudes in Northern Africa and in Australia. Western Europe, though, does not experience such dramatic climate events, except for some African dust reaching it from the Sahara. This modern situation is of particular interest, in the context of future climate projections, since the present interglacial is usually interpreted, in this context, as an analog of the warm Eemian interval. European terrestrial records show, however, major dust events during the penultimate interglacial and early glacial. These events are easily observed in loess records by their whitish-color deposits, which lie above and below dark chernozem paleosols in Central European records of Marine Isotope Stage (MIS 5 age. We describe here the base of the Dolni Vestonice (DV loess sequence, Czech Republic, as the reference of such records. The dust is deposited during intervals that are characterized by poor vegetation – manifested by high δ13C values and low magnetic susceptibility – while the fine sand and clay in the deposits shows grain sizes that are clearly different from the overlying pleniglacial loess deposits. Some of these dust events have been previously described as "Markers" or Marker Silts (MS by one of us (G. Kukla, and are dated at about 111–109 ka and 93–92 ka, with a third and last one slightly visible at about 75–73 ka. Other events correspond to the loess material of Kukla's cycles, and are described as eolian silts (ES; they are observed in the same DV sequence and are dated at about 106–105 ka, 88–86 ka, and 78.5–77 ka. These dates are determined by considering the OSL ages with their errors measured on the studied sequence, and the comparison with Greenland ice-core and European speleothem chronologies. The fine eolian deposits mentioned above, MS as well as ES, correspond to short events that lasted about 2 ka; they are

Running Newton constant, improved gravitational actions, and galaxy rotation curves

International Nuclear Information System (INIS)

Reuter, M.; Weyer, H.

2004-01-01

A renormalization group (RG) improvement of the Einstein-Hilbert action is performed which promotes Newton's constant and the cosmological constant to scalar functions on spacetime. They arise from solutions of an exact RG equation by means of a 'cutoff identification' which associates RG scales to the points of spacetime. The resulting modified Einstein equations for spherically symmetric, static spacetimes are derived and analyzed in detail. The modifications of the Newtonian limit due to the RG evolution are obtained for the general case. As an application, the viability of a scenario is investigated where strong quantum effects in the infrared cause Newton's constant to grow at large (astrophysical) distances. For two specific RG trajectories exact vacuum spacetimes modifying the Schwarzschild metric are obtained by means of a solution-generating Weyl transformation. Their possible relevance to the problem of the observed approximately flat galaxy rotation curves is discussed. It is found that a power law running of Newton's constant with a small exponent of the order 10 -6 would account for their non-Keplerian behavior without having to postulate the presence of any dark matter in the galactic halo

High power semiconductor switches in the 12 kV, 50 kA pulse generator of the SPS beam dump kicker system

CERN Document Server

Bonthond, J; Faure, P; Vossenberg, Eugène B

2001-01-01

Horizontal deflection of the beam in the dump kicker system of the CERN SPS accelerator is obtained with a series of fast pulsed magnets. The high current pulses of 50 kA per magnet are generated with capacitor discharge type generators which, combined with a resistive free-wheel diode circuit, deliver a critically damped half-sine current with a rise-time of 25 ms. Each generator consists of two 25 kA units, connected in parallel to a magnet via a low inductance transmission line.

Constant load and constant displacement stress corrosion in simulated water reactor environments

International Nuclear Information System (INIS)

Lloyd, G.J.

1987-02-01

The stress corrosion behaviour of selected water reactor constructional materials, as determined by constant load or constant displacement test techniques, is reviewed. Experimental results obtained using a very wide range of conditions have been collected in a form for easy reference. A discussion is given of some apparent trends in these data. The possible reasons for these trends are considered together with a discussion of how the observed discrepancies may be resolved. (author)

Reducing uncertainty in Climate Response Time Scale by Bayesian Analysis of the 8.2 ka event

Science.gov (United States)

Lorenz, A.; Held, H.; Bauer, E.; Schneider von Deimling, T.

2009-04-01

We analyze the possibility of uncertainty reduction in Climate Response Time Scale by utilizing Greenland ice-core data that contain the 8.2 ka event within a Bayesian model-data intercomparison with the Earth system model of intermediate complexity, CLIMBER-2.3. Within a stochastic version of the model it has been possible to mimic the 8.2 ka event within a plausible experimental setting and with relatively good accuracy considering the timing of the event in comparison to other modeling exercises [1]. The simulation of the centennial cold event is effectively determined by the oceanic cooling rate which depends largely on the ocean diffusivity described by diffusion coefficients of relatively wide uncertainty ranges. The idea now is to discriminate between the different values of diffusivities according to their likelihood to rightly represent the duration of the 8.2 ka event and thus to exploit the paleo data to constrain uncertainty in model parameters in analogue to [2]. Implementing this inverse Bayesian Analysis with this model the technical difficulty arises to establish the related likelihood numerically in addition to the uncertain model parameters: While mainstream uncertainty analyses can assume a quasi-Gaussian shape of likelihood, with weather fluctuating around a long term mean, the 8.2 ka event as a highly nonlinear effect precludes such an a priori assumption. As a result of this study [3] the Bayesian Analysis showed a reduction of uncertainty in vertical ocean diffusivity parameters of factor 2 compared to prior knowledge. This learning effect on the model parameters is propagated to other model outputs of interest; e.g. the inverse ocean heat capacity, which is important for the dominant time scale of climate response to anthropogenic forcing which, in combination with climate sensitivity, strongly influences the climate systems reaction for the near- and medium-term future. 1 References [1] E. Bauer, A. Ganopolski, M. Montoya: Simulation of the

Construction of Lines of Constant Density and Constant Refractive Index for Ternary Liquid Mixtures.

Science.gov (United States)

Tasic, Aleksandar Z.; Djordjevic, Bojan D.

1983-01-01

Demonstrates construction of density constant and refractive index constant lines in triangular coordinate system on basis of systematic experimental determinations of density and refractive index for both homogeneous (single-phase) ternary liquid mixtures (of known composition) and the corresponding binary compositions. Background information,…

RNA structure and scalar coupling constants

Energy Technology Data Exchange (ETDEWEB)

Tinoco, I. Jr.; Cai, Z.; Hines, J.V.; Landry, S.M.; SantaLucia, J. Jr.; Shen, L.X.; Varani, G. [Univ. of California, Berkeley, CA (United States)

1994-12-01

Signs and magnitudes of scalar coupling constants-spin-spin splittings-comprise a very large amount of data that can be used to establish the conformations of RNA molecules. Proton-proton and proton-phosphorus splittings have been used the most, but the availability of {sup 13}C-and {sup 15}N-labeled molecules allow many more coupling constants to be used for determining conformation. We will systematically consider the torsion angles that characterize a nucleotide unit and the coupling constants that depend on the values of these torsion angles. Karplus-type equations have been established relating many three-bond coupling constants to torsion angles. However, one- and two-bond coupling constants can also depend on conformation. Serianni and coworkers measured carbon-proton coupling constants in ribonucleosides and have calculated their values as a function of conformation. The signs of two-bond coupling can be very useful because it is easier to measure a sign than an accurate magnitude.

Earth’s gravity and the cosmological constant: a worked example

International Nuclear Information System (INIS)

Pereira, J A M

2016-01-01

The cosmological constant regained the attention of the scientific community following the recent discovery of the accelerated expansion of the Universe. Consequently, interest in the subject increased amongst the public such that it now often appears in the classroom and popular science publications. The purpose of this article is to use basic concepts of Newtonian mechanics, like dynamics, kinetic energy and potential energy diagrams, in a scenario where the cosmological constant’s action, considered as being an inertial force driven by the accelerated expansion of the Universe, could counteract Earth’s gravity. The effect that the cosmological constant might have near the Earth’s surface is discussed showing how everyday life would change. This is done in such a way that makes it accessible to students in their first year of college. Finally, the modern interpretation of the cosmological constant, associated with the existence of dark energy, is briefly discussed along with upper limit estimations for its value based on the anthropic principle. (paper)

String-coupling constant and dilaton vacuum expectation value in string field theory

International Nuclear Information System (INIS)

Yoneya, Tamiaki

1987-01-01

In the first quantized approaches to strings, it is well known that the string-coupling constant is determined by the vacuum expectation value of the dilaton field. This property, however, has never been demonstrated within the framework of string field theory. An explicit reparametrization of the string field associated with the shifts of the dilaton vacuum expectation value and the string-coupling constant is constructed exhibiting the above property in the light-cone field theory of the closed bosonic string. (orig.)

Pollen-based continental climate reconstructions at 6 and 21 ka: a global synthesis

Energy Technology Data Exchange (ETDEWEB)

Bartlein, P.J. [University of Oregon, Department of Geography, Eugene, Oregon (United States); Harrison, S.P. [University of Bristol, School of Geographical Sciences, Bristol (United Kingdom); Macquarie University, School of Biological Sciences, North Ryde, NSW (Australia); Brewer, S. [University of Wyoming, Botany Department, Wyoming (United States); Connor, S. [University of the Algarve, Centre for Marine and Environmental Research, Faro (Portugal); Davis, B.A.S. [Ecole Polytechnique Federale de Lausanne, School of Architecture, Civil and Environmental Engineering, Lausanne (Switzerland); Gajewski, K.; Viau, A.E. [University of Ottawa, Department of Geography, Ottawa, ON (Canada); Guiot, J. [CEREGE, Aix-en-Provence cedex 4 (France); Harrison-Prentice, T.I. [GTZ, PAKLIM, Jakarta (Indonesia); Henderson, A. [University of Minnesota, Department of Geology and Geophysics, Minneapolis, MN (United States); Peyron, O. [Laboratoire Chrono-Environnement UMR 6249 CNRS-UFC UFR Sciences et Techniques, Besancon Cedex (France); Prentice, I.C. [Macquarie University, School of Biological Sciences, North Ryde, NSW (Australia); University of Bristol, QUEST, Department of Earth Sciences, Bristol (United Kingdom); Scholze, M. [University of Bristol, QUEST, Department of Earth Sciences, Bristol (United Kingdom); Seppae, H. [University of Helsinki, Department of Geology, P.O. Box 65, Helsinki (Finland); Shuman, B. [University of Wyoming, Department of Geology and Geophysics, Laramie, WY (United States); Sugita, S. [Tallinn University, Institute of Ecology, Tallinn (Estonia); Thompson, R.S. [US Geological Survey, PO Box 25046, Denver, CO (United States); Williams, J. [University of Wisconsin, Department of Geography, Madison, WI (United States); Wu, H. [Chinese Academy of Sciences, Key Laboratory of Cenozoic Geology and Environment, Institute of Geology and Geophysics, Beijing (China)

2011-08-15

Subfossil pollen and plant macrofossil data derived from {sup 14}C-dated sediment profiles can provide quantitative information on glacial and interglacial climates. The data allow climate variables related to growing-season warmth, winter cold, and plant-available moisture to be reconstructed. Continental-scale reconstructions have been made for the mid-Holocene (MH, around 6 ka) and Last Glacial Maximum (LGM, around 21 ka), allowing comparison with palaeoclimate simulations currently being carried out as part of the fifth Assessment Report (AR5) of the Intergovernmental Panel on Climate Change. The synthesis of the available MH and LGM climate reconstructions and their uncertainties, obtained using modern-analogue, regression and model-inversion techniques, is presented for four temperature variables and two moisture variables. Reconstructions of the same variables based on surface-pollen assemblages are shown to be accurate and unbiased. Reconstructed LGM and MH climate anomaly patterns are coherent, consistent between variables, and robust with respect to the choice of technique. They support a conceptual model of the controls of Late Quaternary climate change whereby the first-order effects of orbital variations and greenhouse forcing on the seasonal cycle of temperature are predictably modified by responses of the atmospheric circulation and surface energy balance. (orig.)

Design of Highly Selective Platinum Nanoparticle Catalysts for the Aerobic Oxidation of KA-Oil using Continuous-Flow Chemistry.

Science.gov (United States)

Gill, Arran M; Hinde, Christopher S; Leary, Rowan K; Potter, Matthew E; Jouve, Andrea; Wells, Peter P; Midgley, Paul A; Thomas, John M; Raja, Robert

2016-03-08

Highly active and selective aerobic oxidation of KA-oil to cyclohexanone (precursor for adipic acid and ɛ-caprolactam) has been achieved in high yields using continuous-flow chemistry by utilizing uncapped noble-metal (Au, Pt & Pd) nanoparticle catalysts. These are prepared using a one-step in situ methodology, within three-dimensional porous molecular architectures, to afford robust heterogeneous catalysts. Detailed spectroscopic characterization of the nature of the active sites at the molecular level, coupled with aberration-corrected scanning transmission electron microscopy, reveals that the synthetic methodology and associated activation procedures play a vital role in regulating the morphology, shape and size of the metal nanoparticles. These active centers have a profound influence on the activation of molecular oxygen for selective catalytic oxidations. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Ka Hana `Imi Na`auao: A Science Curriculum Project

Science.gov (United States)

Napeahi, K.; Roberts, K. D.; Galloway, L. M.; Stodden, R. A.; Akuna, J.; Bruno, B.

2005-12-01

In antiquity, the first people to step foot on what are now known as the Hawaiian islands skillfully traversed the Pacific Ocean using celestial navigation and learned observations of scientific phenomena. Long before the Western world ventured beyond the horizon, Hawaiians had invented the chronometer, built aqueduct systems (awai) that continue to amaze modern engineers, and had preventive health systems as well as a comprehensive knowledge of medicinal plants (including antivirals) which only now are working their way through trials for use in modern pharmacopia. Yet, today, Native Hawaiians are severely underrepresented in science-related fields, reflecting (in part) a failure of the Western educational system to nurture the potential of these resourceful students, particularly the many "at-risk" students who are presently over-represented in special education. A curriculum which draws from and incorporates traditional Hawaiian values and knowledge is needed to reinforce links to the inquiry process which nurtured creative thinking during the renaissance of Polynesian history. The primary goal of the Ka Hana `Imi Na`auao Project (translation: `science` or `work in which you seek enlightenment, knowledge or wisdom`) is to increase the number of Native Hawaiian adults in science-related postsecondary education and employment fields. Working closely with Native Hawaiian cultural experts and our high school partners, we will develop and implement a culturally responsive 11th and 12th grade high school science curriculum, infused with math, literacy and technology readiness skills. Software and assistive technology will be used to adapt instruction to individual learners` reading levels, specific disabilities and learning styles. To ease the transition from secondary to post-secondary education, selected grade 12 students will participate in planned project activities that link high school experiences with college science-related programs of study. Ka Hana `Imi Na

Stability Constants of Some Biologically Important Pyrazoles and Their Ni2+ Complexes in Different Dielectric Constant of Medium

Directory of Open Access Journals (Sweden)

S. D. Deosarkar

2012-01-01

Full Text Available The proton-ligand stability constants of some biologically important new pyrazoles and formation constants of their complexes with Ni(II were determined at 0.1 mol dm-3 ionic strength and at 303.15 K in different dielectric constant of dioxane-water mixture by potentiometric method. The Calvin-Bjerrum's pH-titration technique as used by Irving and Rossotti was used for determination of stability constants. The results enabled to study the electrostatic forces of attraction between metal ion and ligand with changes in dielectric constant of the medium.

Trace-element deposition in the Cariaco Basin, Venezuela Shelf, under sulfate-reducing conditions: a history of the local hydrography and global climate, 20 ka to the present

Science.gov (United States)

Piper, David Z.; Dean, Walter E.

2002-01-01

A sediment core from the Cariaco Basin on the Venezuelan continental shelf, which recovered sediment that has been dated back to 20 ka (thousand years ago), was examined for its major-element-oxide and trace-element composition. Cadmium (Cd), chromium (Cr), copper (Cu), molybdenum (Mo), nickel (Ni), vanadium (V), and zinc (Zn) can be partitioned between a siliciclastic, terrigenous-derived fraction and two seawater-derived fractions. The two marine fractions are (1) a biogenic fraction represented by nutrient trace elements taken up mostly in the photic zone by phytoplankton, and (2) a hydrogenous fraction that has been derived from bottom water via adsorption and precipitation reactions. This suite of trace elements contrasts with a second suite of trace elements—barium (Ba), cobalt (Co), gallium (Ga), lithium (Li), the rare-earth elements, thorium (Th), yttrium (Y), and several of the major-element oxides—that has had solely a terrigenous source. The partitioning scheme, coupled with bulk sediment accumulation rates measured by others, allows us to determine the accumulation rate of trace elements in each of the three sediment fractions and of the fractions themselves. The current export of organic matter from the photic zone, redox conditions and advection of bottom water, and flux of terrigenous debris into the basin can be used to calculate independently trace-element depositional rates. The calculated rates show excellent agreement with the measured rates of the surface sediment. This agreement supports a model of trace-element accumulation rates in the subsurface sediment that gives a 20-kyr history of upwelling into the photic zone (that is, primary productivity), bottom-water advection and redox, and provenance. Correspondence of extrema in the geochemical signals with global changes in sea level and climate demonstrates the high degree to which the basin hydrography and provenance have responded to the paleoceanographic and paleoclimatic regimes of

Reverberation Mapping of the Kepler-Field AGN KA1858+4850

Science.gov (United States)

Pei, Liuyi; Barth, Aaron J.; Aldering, Greg S.; Briley, Michael M.; Carroll, Carla J.; Carson, Daniel J.; Cenko, S., Bradley; Clubb, Kelsey I.; Cohen, Daniel P.; Cucchiara, Antonino;

Reverberation Mapping of the KEPLER Field AGN KA1858+4850

Science.gov (United States)

Pei, Liuyi; Barth, Aaron J.; Aldering, Greg S.; Briley, Michael M.; Carroll, Carla J.; Carson, Daniel J.; Cenko, S. Bradley; Clubb, Kelsey I.; Cohen, Daniel P.; Cucchiara, Antonino; Desjardins, Tyler D.; Edelson, Rick; Fang, Jerome J.; Fedrow, Joseph M.; Filippenko, Alexei V.; Fox, Ori D.; Furniss, Amy; Gates, Elinor L.; Gregg, Michael; Gustafson, Scott; Horst, J. Chuck; Joner, Michael D.; Kelly, Patrick L.; Lacy, Mark; Laney, C. David; Leonard, Douglas C.; Li, Weidong; Malkan, Matthew A.; Margon, Bruce; Neeleman, Marcel; Nguyen, My L.; Prochaska, J. Xavier; Ross, Nathaniel R.; Sand, David J.; Searcy, Kinchen J.; Shivvers, Isaac S.; Silverman, Jeffrey M.; Smith, Graeme H.; Suzuki, Nao; Smith, Krista Lynne; Tytler, David; Werk, Jessica K.; Worseck, Gábor

2014-11-01

KA1858+4850 is a narrow-line Seyfert 1 galaxy at redshift 0.078 and is among the brightest active galaxies monitored by the Kepler mission. We have carried out a reverberation mapping campaign designed to measure the broad-line region size and estimate the mass of the black hole in this galaxy. We obtained 74 epochs of spectroscopic data using the Kast Spectrograph at the Lick 3 m telescope from 2012 February to November, and obtained complementary V-band images from five other ground-based telescopes. We measured the Hβ light curve lag with respect to the V-band continuum light curve using both cross-correlation techniques (CCF) and continuum light curve variability modeling with the JAVELIN method and found rest-frame lags of τ CCF = 13.53+2.03-2.32 days and τ JAVELIN = 13.15+1.08-1.00 days. The Hβ rms line profile has a width of σline = 770 ± 49 km s-1. Combining these two results and assuming a virial scale factor of f = 5.13, we obtained a virial estimate of M{BH} = 8.06+1.59-1.72 × 106 {M}⊙ for the mass of the central black hole and an Eddington ratio of L/L Edd ≈ 0.2. We also obtained consistent but slightly shorter emission-line lags with respect to the Kepler light curve. Thanks to the Kepler mission, the light curve of KA1858+4850 has among the highest cadences and signal-to-noise ratios ever measured for an active galactic nucleus; thus, our black hole mass measurement will serve as a reference point for relations between black hole mass and continuum variability characteristics in active galactic nuclei.

Reverberation mapping of the Kepler field AGN KA1858+4850

Energy Technology Data Exchange (ETDEWEB)

Pei, Liuyi; Barth, Aaron J.; Carson, Daniel J. [Department of Physics and Astronomy, University of California, Irvine, CA, 92697 (United States); Aldering, Greg S.; Cucchiara, Antonino [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Briley, Michael M. [Department of Physics and Astronomy, Appalachian State University, Boone, NC 28608 (United States); Carroll, Carla J. [Department of Physics and Astronomy, N283 ESC, Brigham Young University, Provo, UT 84602 (United States); Cenko, S. Bradley; Edelson, Rick [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Clubb, Kelsey I.; Cohen, Daniel P.; Filippenko, Alexei V.; Fox, Ori D. [Department of Astronomy, University of California, Berkeley, CA 94720-3411 (United States); Desjardins, Tyler D. [Department of Physics and Astronomy, The University of Western Ontario, London, ON N6A 3K7 (Canada); Fang, Jerome J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States); Fedrow, Joseph M. [Department of Astronomy, San Diego State University, San Diego, CA 92182 (United States); Furniss, Amy [Department of Physics, Stanford University, 382 Via Pueblo Mall, Stanford, CA 94305 (United States); Gates, Elinor L. [Lick Observatory, P.O. Box 85, Mt. Hamilton, CA 95140 (United States); Gregg, Michael [Department of Physics, University of California, Davis, One Shields Avenue, Davis, CA 95616 (United States); Gustafson, Scott [Department of Physics, University of California, San Diego, La Jolla, CA 92093 (United States); and others

2014-11-01

KA1858+4850 is a narrow-line Seyfert 1 galaxy at redshift 0.078 and is among the brightest active galaxies monitored by the Kepler mission. We have carried out a reverberation mapping campaign designed to measure the broad-line region size and estimate the mass of the black hole in this galaxy. We obtained 74 epochs of spectroscopic data using the Kast Spectrograph at the Lick 3 m telescope from 2012 February to November, and obtained complementary V-band images from five other ground-based telescopes. We measured the Hβ light curve lag with respect to the V-band continuum light curve using both cross-correlation techniques (CCF) and continuum light curve variability modeling with the JAVELIN method and found rest-frame lags of τ{sub CCF}=13.53{sub −2.32}{sup +2.03} days and τ {sub JAVELIN} =13.15{sub −1.00}{sup +1.08} days. The Hβ rms line profile has a width of σ{sub line} = 770 ± 49 km s{sup –1}. Combining these two results and assuming a virial scale factor of f = 5.13, we obtained a virial estimate of M{sub BH}=8.06{sub −1.72}{sup +1.59}×10{sup 6}M{sub ⊙} for the mass of the central black hole and an Eddington ratio of L/L {sub Edd} ≈ 0.2. We also obtained consistent but slightly shorter emission-line lags with respect to the Kepler light curve. Thanks to the Kepler mission, the light curve of KA1858+4850 has among the highest cadences and signal-to-noise ratios ever measured for an active galactic nucleus; thus, our black hole mass measurement will serve as a reference point for relations between black hole mass and continuum variability characteristics in active galactic nuclei.

A natural cosmological constant from chameleons

International Nuclear Information System (INIS)

Nastase, Horatiu; Weltman, Amanda

2015-01-01

We present a simple model where the effective cosmological constant appears from chameleon scalar fields. For a Kachru–Kallosh–Linde–Trivedi (KKLT)-inspired form of the potential and a particular chameleon coupling to the local density, patches of approximately constant scalar field potential cluster around regions of matter with density above a certain value, generating the effect of a cosmological constant on large scales. This construction addresses both the cosmological constant problem (why Λ is so small, yet nonzero) and the coincidence problem (why Λ is comparable to the matter density now)

A natural cosmological constant from chameleons

Directory of Open Access Journals (Sweden)

Horatiu Nastase

2015-07-01

Full Text Available We present a simple model where the effective cosmological constant appears from chameleon scalar fields. For a Kachru–Kallosh–Linde–Trivedi (KKLT-inspired form of the potential and a particular chameleon coupling to the local density, patches of approximately constant scalar field potential cluster around regions of matter with density above a certain value, generating the effect of a cosmological constant on large scales. This construction addresses both the cosmological constant problem (why Λ is so small, yet nonzero and the coincidence problem (why Λ is comparable to the matter density now.

A natural cosmological constant from chameleons

Energy Technology Data Exchange (ETDEWEB)

Nastase, Horatiu, E-mail: nastase@ift.unesp.br [Instituto de Física Teórica, UNESP-Universidade Estadual Paulista, R. Dr. Bento T. Ferraz 271, Bl. II, Sao Paulo 01140-070, SP (Brazil); Weltman, Amanda, E-mail: amanda.weltman@uct.ac.za [Astrophysics, Cosmology & Gravity Center, Department of Mathematics and Applied Mathematics, University of Cape Town, Private Bag, Rondebosch 7700 (South Africa)

2015-07-30

We present a simple model where the effective cosmological constant appears from chameleon scalar fields. For a Kachru–Kallosh–Linde–Trivedi (KKLT)-inspired form of the potential and a particular chameleon coupling to the local density, patches of approximately constant scalar field potential cluster around regions of matter with density above a certain value, generating the effect of a cosmological constant on large scales. This construction addresses both the cosmological constant problem (why Λ is so small, yet nonzero) and the coincidence problem (why Λ is comparable to the matter density now)

On the constant-roll inflation

Science.gov (United States)

Yi, Zhu; Gong, Yungui

2018-03-01

The primordial power spectra of scalar and tensor perturbations during slow-roll inflation are usually calculated with the method of Bessel function approximation. For constant-roll or ultra slow-roll inflation, the method of Bessel function approximation may be invalid. We compare the numerical results with the analytical results derived from the Bessel function approximation, and we find that they differ significantly on super-horizon scales if the constant slow-roll parameter ηH is not small. More accurate method is needed for calculating the primordial power spectrum for constant-roll inflation.

Ka-band IQ vector modulator employing GaAs HBTs

International Nuclear Information System (INIS)

Cao Yuxiong; Wu Danyu; Chen Gaopeng; Jin Zhi; Liu Xinyu

2011-01-01

The importance of high-performance, low-cost and millimeter-wave transmitters for digital communications and radar applications is increasing. The design and performance of a Ka-band balanced in-phase and quadrature-phase (I-Q) type vector modulator, using GaAs heterojunction bipolar transistors (HBTs) as switching elements, are presented. The balanced technique is used to remove the parasitics of the HBTs to result in near perfect constellations. Measurements of the monolithic microwave integrated circuit (MMIC) chip with a size of 1.89 x 2.26 mm 2 demonstrate an amplitude error below 1.5 dB and the phase error within 3 0 between 26 and 40 GHz except for a singular point at 35.6 GHz. The results show that the technique is suitable for millimeter-wave digital communications. (semiconductor integrated circuits)

Experience of 12 kA / 16 V SMPS during the HTS Current Leads Test

Science.gov (United States)

Panchal, P.; Christian, D.; Panchal, R.; Sonara, D.; Purwar, G.; Garg, A.; Nimavat, H.; Singh, G.; Patel, J.; Tanna, V.; Pradhan, S.

2017-04-01

As a part of up gradation plans in SST-1 Tokamak, one pair of 3.3 kA rated prototype hybrid current leads were developed using Di-BSCCO as High Temperature Superconductors (HTS) and the copper heat exchanger. In order to validate the manufacturing procedure prior to go for series production of such current leads, it was recommended to test these current leads using dedicated and very reliable DC switch mode power supply (SMPS). As part of test facility, 12 kA, 16 VDC programmable SMPS was successfully installed, commissioned and tested. This power supply has special features such as modularity, N+1 redundancy, very low ripple voltage, precise current measurements with Direct Current Current Transformer, CC/CV modes with auto-crossover and auto-sequence programming. As a part of acceptance of this converter, A 5.8 mΩ water-cooled resistive dummy load and PLC based SCADA system is designed, developed for commissioning of power supply. The same power supply was used for the testing of the prototype HTS current leads. The paper describes the salient features and experience of state-of-art of power supply and results obtained from this converter during the HTS current leads test.

FOREWORD: International determination of the Avogadro constant International determination of the Avogadro constant

Science.gov (United States)

Massa, Enrico; Nicolaus, Arnold

2011-04-01

the mass-energy-frequency equivalence. Another effort is to monitor the stability of the Pt-Ir prototype: the technologies described in the present issue can be refined and finalized to calculate the mass variation of 1 kg 28Si spheres by monitoring the surface evolution without weighing them on a balance. The last activity is the determination of the mass of a 28Si sphere by electrical measurements using a watt balance and without any reference to the Pt-Ir prototype. In this framework, it will be necessary to demonstrate the mutual consistency and the stability of both the electrical and crystal mise en pratique of a kilogram definition based on a conventional value of the Planck constant. A related issue is to develop suitable procedures and protocols to disseminate the unit of mass from the new realizations. Since the molar Planck constant is well known via the measurement of the Rydberg constant, the accurate measurement of NA also provides an accurate and independent determination of the Planck constant, h. A comparison of the values of the Planck constant obtained via the watt-balance experiment and the NA determination tests quantum mechanics. In fact, the watt-balance value of h depends on solid state physics through the theories of Josephson and quantum Hall effects, whereas the value of h derived from NA depends on atomic physics through the energy level differences in hydrogen and deuterium, whose associated transition frequencies yield information on the Rydberg constant. Grateful thanks are addressed to H-J Pohl for his outstanding project management in Russia, to A K Kaliteevski and his colleagues of the Central Design Bureau of Machine Building and the Institute of Chemistry of High-Purity Substances for their dedication and the punctual delivery of the enriched material, to H Riemann and his staff of the Institut für Kristallzüchtung for the crystal growth, to our directors for their advice and financial support, and to our colleagues for their

The fundamental constants a mystery of physics

CERN Document Server

Fritzsch, Harald

2009-01-01

The speed of light, the fine structure constant, and Newton's constant of gravity — these are just three among the many physical constants that define our picture of the world. Where do they come from? Are they constant in time and across space? In this book, physicist and author Harald Fritzsch invites the reader to explore the mystery of the fundamental constants of physics in the company of Isaac Newton, Albert Einstein, and a modern-day physicist

Invited Article: A precise instrument to determine the Planck constant, and the future kilogram

International Nuclear Information System (INIS)

Haddad, D.; Seifert, F.; Williams, C.; Chao, L. S.; Li, S.; Newell, D. B.; Pratt, J. R.; Schlamminger, S.

2016-01-01

A precise instrument, called a watt balance, compares mechanical power measured in terms of the meter, the second, and the kilogram to electrical power measured in terms of the volt and the ohm. A direct link between mechanical action and the Planck constant is established by the practical realization of the electrical units derived from the Josephson and the quantum Hall effects. We describe in this paper the fourth-generation watt balance at the National Institute of Standards and Technology (NIST), and report our initial determination of the Planck constant obtained from data taken in late 2015 and the beginning of 2016. A comprehensive analysis of the data and the associated uncertainties led to the SI value of the Planck constant, h = 6.626 069 83(22) × 10 −34 J s. The relative standard uncertainty associated with this result is 34 × 10 −9 .

Invited Article: A precise instrument to determine the Planck constant, and the future kilogram

Energy Technology Data Exchange (ETDEWEB)

Haddad, D., E-mail: darine.haddad@nist.gov; Seifert, F.; Williams, C. [National Institute of Standards and Technology (NIST), 100 Bureau Drive Stop 8171, Gaithersburg, Maryland 20899 (United States); University of Maryland, Joint Quantum Institute, College Park, Maryland 20742 (United States); Chao, L. S.; Li, S.; Newell, D. B.; Pratt, J. R.; Schlamminger, S., E-mail: stephan.schlamminger@nist.gov [National Institute of Standards and Technology (NIST), 100 Bureau Drive Stop 8171, Gaithersburg, Maryland 20899 (United States)

2016-06-15

A precise instrument, called a watt balance, compares mechanical power measured in terms of the meter, the second, and the kilogram to electrical power measured in terms of the volt and the ohm. A direct link between mechanical action and the Planck constant is established by the practical realization of the electrical units derived from the Josephson and the quantum Hall effects. We describe in this paper the fourth-generation watt balance at the National Institute of Standards and Technology (NIST), and report our initial determination of the Planck constant obtained from data taken in late 2015 and the beginning of 2016. A comprehensive analysis of the data and the associated uncertainties led to the SI value of the Planck constant, h = 6.626 069 83(22) × 10{sup −34} J s. The relative standard uncertainty associated with this result is 34 × 10{sup −9}.

Variation of paleo-productivity and terrigenous input in the eastern Arabian Sea during the past 100 ka

Digital Repository Service at National Institute of Oceanography (India)

Ishfaq, A.M.; Pattan, J.N.; Matta, V.M.; Banakar, V.K.

A 4.1m long sediment core from the eastern Arabian Sea is studied using multiple geochemical proxies to understand the variation of productivity and terrigenous matter supply during the past 100 ka. The temporal variation in element concentration...

Compatibility of polyvinyl alcohol and poly(methyl vinyl ether-co-maleic acid) blends estimated by molecular dynamics

CSIR Research Space (South Africa)

Moolman, FS

2005-07-25

Full Text Available are not dissociated (ionized). At pH below pKa (negative logarithm of acid dissociation constant) of maleic acid (first and second dissociation constants at 25 8C are pKa1Z1.91 and pKa 2Z6.33, respectively [22]), ioniz- ation of the carboxylic acid groups in the PMVE...-MA. Decreasing pH also reduces absolute viscosities and broadens the optimum blend ratio peak. Fig. 2. Density of a selected number of runs (11?15) as a function of time. F.S. Moolman et al. / Polymer 46 (2005) 6192?6200 6195 The cohesive energy densities display...

Decay constants in soft wall AdS/QCD revisited

Directory of Open Access Journals (Sweden)

Nelson R.F. Braga

2016-12-01

We show here that a modified framework of soft wall AdS/QCD involving an additional dimensionfull parameter, associated with an ultraviolet energy scale, provides decay constants decreasing with radial excitation level. In this version of the soft wall model the two point function of gauge theory operators is calculated at a finite position of the anti-de Sitter space radial coordinate.

Hydrodynamics of the groundwater-fed Sian Ka'an Wetlands, Mexico, From InSAR and SAR Data

DEFF Research Database (Denmark)

Gondwe, Bibi Ruth Neuman; Hong, S.; Wdowinski, S.

2008-01-01

The 5300 km2 pristine Sian Ka'an wetland in Mexico is fed entirely by groundwater from the karst aquifer of the Yucatan Peninsula. The area is undeveloped and hence difficult to access. The inflow through underground rivers and karst structures is hard to observe resulting in difficulties......-changes of the backscattered radar signal, which can be related to the water level changes in vegetated wetlands. SAR data reveals information of surface properties such as the degree of flooding through the amplitude of the backscattered signal. We used RADARSAT-1 InSAR and SAR data to form 36 interferograms and 13 flooding...... maps with 24 to 48 day intervals covering the time span of October 2006 to March 2008. The dataset has a high spatial resolution of ca. 20 to 60 m. Sian Ka'an consists of a mosaic of freshwater sloughs, canals, floodplains and brackish tidally-influenced areas. Throughout most of the year, water level...

Conceptual design of a forced-flow-cooled 20-kA current lead using Ag-alloy-sheathed Bi-2223 high-temperature superconductors

International Nuclear Information System (INIS)

Heller, R.

1994-11-01

The use of high-temperature superconductors in current leads to reduce refrigeration power has been investigated by many groups in the past. Most used YBCO and Bi-2212 bulk superconductors, although their critical current density is not very high. In this paper, BI-2223 HTSC tapes sheathed with Ag alloys are used in the design of a 20-kA current lead because of their higher critical current in medium magnetic fields. The lead current of 20 kA is related to the coil current of the planned stellarator WENDELSTEIN 7-X. Forced-now helium cooling has been used in the design, allowing position-independent and well-controlled operation. The design characteristics of the lead are presented and 4-K helium cooling of the whole lead, as well as 60-K helium cooling of the copper part of the lead, is discussed. The power consumption at zero current, and the lead's behaviour in case of loss of coolant flow, are given, The results of the design allow extrapolation to current leads of the 50-kA range

Constant Leverage And Constant Cost Of Capital: A Common Knowledge Half-Truth

Directory of Open Access Journals (Sweden)

Ignacio Vélez–Pareja

2008-04-01

In this document we show that for finite cash flows, Ke and hence WACC depend on the discount rate that is used to value the tax shield, TS and as expected, Ke and WACC are not constant with Kd as the discount rate for the tax shield, even if the leverage is constant. We illustrate this situation with a simple example. We analyze five methods: DCF using APV, FCF and traditional and general formulation for WACC, present value of CFE plus debt and Capital Cash Flow, CCF.

Energy, stability and cosmological constant

International Nuclear Information System (INIS)

Deser, S.

1982-01-01

The definition of energy and its use in studying stability in general relativity are extended to the case when there is a nonvanishing cosmological constant Λ. Existence of energy is first demonstrated for any model (with arbitrary Λ). It is defined with respect to sets of solutions tending asymptotically to any background space possessing timelike Killing symmetry, and is both conserved and of flux integral form. When Λ O, small excitations about De Sitter space are stable inside the event horizon. Outside excitations can contribute negatively due to the Killing vector's flip at the horizon. This is a universal phenomenon associated with the possibility of Hawking radiation. Apart from this effect, the Λ>O theory appears to be stable, also at the semi-classical level. (author)

Impact of Surface Soil Moisture Variations on Radar Altimetry Echoes at Ku and Ka Bands in Semi-Arid Areas

Directory of Open Access Journals (Sweden)

Christophe Fatras

2018-04-01

Full Text Available Radar altimetry provides information on the topography of the Earth surface. It is commonly used for the monitoring not only sea surface height but also ice sheets topography and inland water levels. The radar altimetry backscattering coefficient, which depends on surface roughness and water content, can be related to surface properties such as surface soil moisture content. In this study, the influence of surface soil moisture on the radar altimetry echo and backscattering coefficient is analyzed over semi-arid areas. A semi-empirical model of the soil’s complex dielectric permittivity that takes into account that small-scale roughness and large-scale topography was developed to simulate the radar echoes. It was validated using waveforms acquired at Ku and Ka-bands by ENVISAT RA-2 and SARAL AltiKa respectively over several sites in Mali. Correlation coefficients ranging from 0.66 to 0.94 at Ku-band and from 0.27 to 0.96 at Ka-band were found. The increase in surface soil moisture from 0.02 to 0.4 (i.e., the typical range of variations in semi-arid areas increase the backscattering from 10 to 15 dB between the core of the dry and the maximum of the rainy seasons.

Felix Vodička: Úkoly literární historie a jejich zdroj

Czech Academy of Sciences Publication Activity Database

Kubíček, Tomáš

2010-01-01

Roč. 92, 1/2 (2010), s. 85-94 ISSN 0862-8459. [100 let generace prvních žáků PLK. Praha, 09.02.2009-09.02.2009] R&D Projects: GA ČR GA405/07/0077 Institutional research plan: CEZ:AV0Z90560517 Keywords : history of literature * Vodička, Felix * structuralism Subject RIV: AJ - Letters, Mass-media, Audiovision

Alati peab olema valmis mitte ainult plaan B, vaid ka C, D, E ... / Ülle Järv

Index Scriptorium Estoniae

Järv, Ülle, 1958-

2008-01-01

Ilmunud ka: Finansovõi Menedzhment : infovõpusk nr. 22 märts lk. 8-9. Baltika strateegiline pööre sisaldas kolme teemat: uue strateegia finantseerimine, uue finantsaruandlussüsteemi ülesehitamine ning riskide määratlemine ja juhtimine

Žumberačka Gora – Transformation from a Refuge to an Exodus Zone

Directory of Open Access Journals (Sweden)

Ivan Crkvenčić

2002-12-01

Full Text Available This article provides an analysis of the problem of immigration from Žumberačka gora, a highland region that lies on the border between Croatia and Slovenia. Due consideration is given to its border-zone character, basic features and later colonization during the mid-sixteenth century. A dual social organization and even social relations emerged in the region, reflecting the contrast between the Military Frontier and the civilian portion. The consequences of long settlement and secondary colonization led to agrarian overpopulation and difficult living conditions. Social and overriding economic changes throughout the country by the mid-nineteenth century compelled the population of Žumberačka gora to begin departing from the region. Intense immigration gradually caused negative natural growth, i.e. a natural decline in the population. Natural decline (number of deaths exceeding the number of live births and emigration were gradually reflected in the lower numbers and advanced age of the population. These processes were particularly marked in the military frontier portion of the region – in Žumberak – which accounts for almost three fourths of this highland region’s territory. In this part of the region the population has been numerically declining since 1931, but particularly since 1971. Today only one fifth of the population recorded in 1953 (just after World War II lives in Žumberak. This drop is a result of both natural decline and immigration. The age structure of the region’s remaining population is dominated by the elderly, which is shown by demographic aging indicators. Such a population is not a sound prerequisite for the region’s economic revival. The basic features of Žumberak’s landscape are deserted or devastated villages with many abandoned tracts of once arable land. A formerly densely populated region that could not feed its own residents has become a zone marked by a population exodus, an area lacking a labor

Stratigraphic reconstruction of the 13 ka BP debris avalanche deposit at Colima volcano (Mexico): effect of climatic conditions on the flow mobility

Science.gov (United States)

Roverato, M.; Capra, L.

2010-12-01

Colima volcano is an andesitic stratovolcano located in the western part of the Trans-Mexican Volcanic Belt (TMVB) and at the southern end of the N-S trending Colima graben, about 70 km from the Pacific Ocean coast. It is probably the most active Mexican volcano in historic time and one of the most active of North America. Colima volcano yielded numerous partial edifice collapses with emplacement of debris avalanche deposits (DADs) of contrasting volume, morphology, texture and origin. This work has the aim to provide the evidences of how the climatic condition during the 13 ka flank collapse of the Colima volcano affected the textural characteristic and the mobility of the debris avalanche and debris flow originated from this event that occurred just after the Last Glacial Maximum in Mexico (18.4-14.5 ka 14C BP with snow line at 3600 m a.s.l. up to 13 ka BP). The 13,000 yrs old debris avalanche deposit, here named Tonila (TDAD) presents the typical debris avalanche textural characteristics (angular to sub-angular clasts, coarse matrix, jigsaw fit) but at approximately 13 km from the source, the deposit transforms to an hybrid phase with debris avalanche fragments imbedded in a finer, homogenous and indurated matrix more similar to a debris flow deposit. The debris avalanche deposit is directly overly by debris flows, often more than 10 m thick that contains large amount of logs from pine tree, mostly accumulated toward the base and imbricated down flow. Fluvial deposits also occur throughout all successions, representing periods of stream and river reworking highly localized and re-establishment. All these evidences point to the presence of water in the mass previous to the failure. The event here described represent an anomalous event between the previously described deposit associated to volcanic complex, and evidence as climatic condition can alter and modifies the depositional sequences incrementing the hazard.

Acid-base titrations in solvents of relatively low dielectric constant

NARCIS (Netherlands)

Bos, M.; Dahmen, E.A.M.F.

1973-01-01

From a comparison of the pKa values of various compounds in the solvent 1,2-dichloroethane, m-cresol, acetic acid and pyridine, the differences in basicity of these solvents could be determined. If the basicity of 1,2-dichloroethane is taken as 0 pK units, the basicities of m-cresol, acetic acid and

Preliminary checklist of Myxomycota and Ascomycota from Fruška Gora mountain

Directory of Open Access Journals (Sweden)

Karaman Maja A.

2012-01-01

Full Text Available Fruška Gora mountain represents very important source of natural and semi-natural forest ecosystems in the northern part of the Republic of Serbia and therefore it is important source of habitats for different groups of fungi. As opposed to coordinated inventory and monitoring projects of fungi established around Europe long ago, mycological researches in Serbia are still sporadic and insufficiently coordinated by authorities and experts. In accordance with that, available data concerning the state of fungi in Serbia are scarce. The aim of this work was to collect all relevant unpublished data considering fungi in Fruška Gora and to present checklist of two fungal phyla: Myxomycota and Ascomycota. In the presented checklist, 23 recorded species of Myxomycota (known as fungal analogues were distributed in 2 classes, 5 orders, and 7 families. The first class (Protosteliomycetes contained only one species - Ceratiomyxa fruticulosa (fam. Ceratiomyxaceae. The largest order was Trichiales (9 species, while the dominant families were Stemonitidaceae and Trichiaceae, each with 6 species recorded. The most abundant species was Lycogala epidendrum (fam. Reticulariaceae, with 13 records. Phylum Ascomycota was represented with 95 species belonging to 6 classes, 12 orders and 29 families. The most highly represented classes were Leotiomycetes (32 species and Pezizomycetes (31 species. The most abundant species were: Xylaria polymorpha (17 records, Xylaria hypoxylon (14 records, and Sarcoscypha coccinea (14 records. [Projekat Ministarstva nauke Republike Srbije, br. III-43002

Constant strength fuel-fuel cell

International Nuclear Information System (INIS)

Vaseen, V.A.

1980-01-01

A fuel cell is an electrochemical apparatus composed of both a nonconsumable anode and cathode; and electrolyte, fuel oxidant and controls. This invention guarantees the constant transfer of hydrogen atoms and their respective electrons, thus a constant flow of power by submergence of the negative electrode in a constant strength hydrogen furnishing fuel; when said fuel is an aqueous absorbed hydrocarbon, such as and similar to ethanol or methnol. The objective is accomplished by recirculation of the liquid fuel, as depleted in the cell through specific type membranes which pass water molecules and reject the fuel molecules; thus concentrating them for recycle use

A 27 ka paleoenvironmental lake sediment record from Taro Co, central Tibetan Plateau: implications for the interplay between monsoon and the Westerlies

Science.gov (United States)

Wang, J.; Ma, Q.; Huang, L.; Ju, J.; Guo, Y.; Lin, X.; Li, Y.; Zhu, L.

2017-12-01

The climate of Tibetan Plateau (TP) is mainly influenced by the Indian Ocean Summer Monsoon (IOSM) and the Westerlies. The interaction of these two air masses is therefore a crucial scientific issue to understand how they impact the climate in this area, especially in the geological times. However, constrained by the available archives, researches on this topic are still very few in the hinterland of the TP, especially covering the Last Glacial Maximum (LGM) period. Here we present a new lake sediment record retrieved from Taro Co covering the last 27 ka to elucidate how the IOSM and the Westerlies interact and the possible mechanisms. Taro Co (486 km2, Dmax: 132m, 4565 m a.s.l., currently closed), located on the central TP, is a fresh lake with the major supply from glaciers. Two parallel piston cores as well as several gravity cores were retrieved from the deepest parts. These cores were correlated based on high resolution XRF scanning and a continuous 1069 cm-long core was finally integrated. Chronology was determined by 210Pb, 137Cs and AMS 14C measurements. Multidiscipline analyses including grain size, total organic carbon (TOC), total nitrogen, diatom, ostracod, pollen and n-alkanes were accomplished to reconstruct paleoenvironmental changes. The lake level of Taro Co was low since 27 cal ka BP indicated by very coarse materials and diatom assemblages with gradually increased temperature and salinity (TOC and carbonate getting higher). The terrestrial water input decreased continuously reflected by such elements as Si, Ti, Fe, K. It is likely that there was a sedimentation gap between 961-954cm, corresponding to 23.4 to 18.6 cal ka BP probably demonstrated Taro Co was very shallow at that period. The first prominent abrupt change of most proxies was observed at 14.7 cal ka BP showing a great lake deepening which likely indicated an enhancement of IOSM. There were several spells with abrupt changes of cold/warm stages before the Holocene and the Younger Dryas

Design optimization of 600 A-13 kA current leads for the Large Hadron Collider project at CERN

CERN Document Server

Spiller, D M; Al-Mosawl, M K; Friend, C M; Thacker, P; Ballarino, A

2001-01-01

The requirements of the Large Hadron Collider project at CERN for high-temperature superconducting (HTS) current leads have been widely publicized. CERN require hybrid current leads of resistive and HTS materials with current ratings of 600 A, 6 kA and 13 kA. BICC General Superconductors, in collaboration with the University of Southampton, have developed and manufactured prototype current leads for the Large Hadron Collider project. The resistive section consists of a phosphorus de-oxidized copper conductor and heat exchanger and the HTS section is constructed from BICC General's (Pb, Bi)2223 tapes with a reduced thermal conductivity Ag alloy sheath. We present the results of the materials optimization studies for the resistive and the HTS sections. Some results of the acceptance tests at CERN are discussed. (9 refs).

Utjecaj ultrazvuka visokog intenziteta na reološka i pastozna svojstva škroba pšenice

Directory of Open Access Journals (Sweden)

Ivana Ljubić Herceg

2010-01-01

Full Text Available Svrha ovog rada je ispitati utjecaj ultrazvuka visokog i niskog intenziteta na reološka i pastozna svojstva suspenzija škroba pšenice. Ispitivane suspenzije sadrže 10 % pšeničnog škroba te su neposredno nakon pripreme procesirane ultrazvukom. Sva ispitivanja provedena su prije i nakon ultrazvučne obrade u ultrazvučnoj kupelji frekvencije 22 kHz, nominalne snage 150 W te ultrazvučnom sondom frekvencije 24 kHz, nominalne snage 100, 300 i 400 W. Vrijeme ultrazvučne obrade svih uzoraka bilo je 15 i 30 minuta. Reološka svojstva određena su primjenom rotacionog reometra Rheometric Scientific RM-180 pri temperaturi od 20 ˚C, a pastozna svojstva škrobnih suspenzija određena su primjenom Micro Visco-Amylo-Graph, Brabender Ohg Duisburg, Njemačka po metodi ICC Standard 126/1. Ultrazvučna obrada uzrokuje mehaničko oštećenje škrobne granule čime njena unutrašnjost postaje dostupnija vodi tijekom zagrijavanja što ima za posljedicu značajne promjene reoloških i pastoznih svojstava škrobnih suspenzija. Reološki parametri pokazuju da sve suspenzije imaju ne-Newtonski karakter, a ultrazvučni tretmen uzrokovao je značajno povećanje koeficijenta konzistencije svih ispitivanih sustava. Ultrazvučnim procesiranjem došlo je do značajnog sniženja temperature želatinizacije kod svih škrobnih suspenzija. Značajno smanjenje početnih temperatura želatinizacije upućuje na raniji stupanj bubrenja granule tijekom zagrijavanja.

Universe of constant

Science.gov (United States)

Yongquan, Han

2016-10-01

The ideal gas state equation is not applicable to ordinary gas, it should be applied to the Electromagnetic ``gas'' that is applied to the radiation, the radiation should be the ultimate state of matter changes or initial state, the universe is filled with radiation. That is, the ideal gas equation of state is suitable for the Singular point and the universe. Maybe someone consider that, there is no vessel can accommodate radiation, it is because the Ordinary container is too small to accommodate, if the radius of your container is the distance that Light through an hour, would you still think it can't accommodates radiation? Modern scientific determinate that the radius of the universe now is about 1027 m, assuming that the universe is a sphere whose volume is approximately: V = 4.19 × 1081 cubic meters, the temperature radiation of the universe (cosmic microwave background radiation temperature of the universe, should be the closest the average temperature of the universe) T = 3.15k, radiation pressure P = 5 × 10-6 N / m 2, according to the law of ideal gas state equation, PV / T = constant = 6 × 1075, the value of this constant is the universe, The singular point should also equal to the constant Author: hanyongquan

The Geomagnetic Field Recorded in Sediments of the Tuzla Section (the Krasnodar Territory, Russia) over the Time Interval 120-70 ka

DEFF Research Database (Denmark)

Pilipenko, Olga; Abrahamsen, N.; Trubikhin, V. M.

2007-01-01

Petro- and paleomagnetic methods are applied to the study of the lower part of the Early Pleistocene Tuzla section on the Black Sea coast of the Taman Peninsula. This part of the section is composed of marine and lagoonal sediments deposited over the time interval 120-70 ka. The measured curves...... of the variation in the geomagnetic field inclination reveal an anomalous direction dated at ~110 ka which coincides with a similar anomalous direction in the Eltigen section (Ukraine) correlating with the Blake paleomagnetic event. The significant correlation between the time series NRM0.015/SIRM0.015 (Tuzla...

Ka eakad tahavad ja suudavad töötada / Kadi Pärnits

Index Scriptorium Estoniae

Pärnits, Kadi, 1965-

2005-01-01

Ilmunud ka: Sakala 4. mai lk. 2, Lääne Elu 5. mai, lk. 2, Koit 5. mai, lk. 6, Videvik 5. mai lk. 2, Harjumaa 6. mai, lk. 2, Põhjarannik 6. mai, lk. 2, Severnoje Poberezhje 6. mai lk. 2, Hiiu Leht 3. juuni lk. 2, Valgamaalane 9. juuni lk. 2, Pärnu Postimees 5. juuli lk. 15, Vooremaa 26. juuli lk. 2. Sotsiaaldemokraatide algatusest kehtivat töölepinguseadust muuta ja võtta tööandjatelt õigus vabaneda eakast töötajast kohe, kui viimane saab 65 aastaseks

Synthesis of [35]Adamanzane, 1,5,9,13-Tetraazabicyclo [7.7.3]nonadecane, by Oxidative C-N Cleavage of [36]Adamanzane, 1,5,9,13-Tetraazatricyclo[7.7.3.35,13]docosane and Crystal Structure of the Tetraprotonated Bromide Salt of [35]Adamanzane

DEFF Research Database (Denmark)

Springborg, Johan; Pretzmann, Ulla; Nielsen, Bente

1998-01-01

. The four acidic hydrogen atoms are all oriented away from the cavity. The concentration acid dissociation constants of H4[35]adz4+ were determined by potentiometric glass-electrode measurements and 1H and 13C NMR spectroscopy: pKa1=1-2, pKa3=9.65(2) and pKa4=12.09(4) (1 M NaBr, 25 degrees C)....

Retention of ionisable compounds on high-performance liquid chromatography XVI. Estimation of retention with acetonitrile/water mobile phases from aqueous buffer pH and analyte pKa.

Science.gov (United States)

Subirats, Xavier; Bosch, Elisabeth; Rosés, Martí

2006-07-21

In agreement with our previous studies and those of other authors, it is shown that much better fits of retention time as a function of pH are obtained for acid-base analytes when pH is measured in the mobile phase, than when pH is measured in the aqueous buffer when buffers of different nature are used. However, in some instances it may be more practical to measure the pH in the aqueous buffer before addition of the organic modifier. Thus, an open methodology is presented that allows prediction of chromatographic retention of acid-base analytes from the pH measured in the aqueous buffer. The model presented estimates the pH of the buffer and the pKa of the analyte in a particular acetonitrile/water mobile phase from the pH and pKa values in water. The retention of the analyte can be easily estimated, at a buffer pH close to the solute pKa, from these values and from the retentions of the pure acidic and basic forms of the analyte. Since in many instances, the analyte pKa values in water are not known, the methodology has been also tested by using Internet software, at reach of many chemists, which calculates analyte pKa values from chemical structure. The approach is successfully tested for some pharmaceutical drugs.

Larson-Miller Constant of Heat-Resistant Steel

Science.gov (United States)

Tamura, Manabu; Abe, Fujio; Shiba, Kiyoyuki; Sakasegawa, Hideo; Tanigawa, Hiroyasu

2013-06-01

Long-term rupture data for 79 types of heat-resistant steels including carbon steel, low-alloy steel, high-alloy steel, austenitic stainless steel, and superalloy were analyzed, and a constant for the Larson-Miller (LM) parameter was obtained in the current study for each material. The calculated LM constant, C, is approximately 20 for heat-resistant steels and alloys except for high-alloy martensitic steels with high creep resistance, for which C ≈ 30 . The apparent activation energy was also calculated, and the LM constant was found to be proportional to the apparent activation energy with a high correlation coefficient, which suggests that the LM constant is a material constant possessing intrinsic physical meaning. The contribution of the entropy change to the LM constant is not small, especially for several martensitic steels with large values of C. Deformation of such martensitic steels should accompany a large entropy change of 10 times the gas constant at least, besides the entropy change due to self-diffusion.

Mic. ka-ru-ti-je-ja-o y gr. kαλάθιον

Directory of Open Access Journals (Sweden)

Alberto Bernabé Pajares

1976-06-01

Full Text Available After reviewing the not very satisfactory interpretatios given to Myc. ka-ru-ti-je-ja-o (PY Ad 671 the author proposes it to be related with a form *καλύθιον, diminutive of κάλαθος, related with καλαθιον. The alternance u/a is explained on the basis of two different vocalizations of *H3u̯, a fact of which there are parallels in Indo-European (cf. Het. kaluti- and in Mycenaean (cf. da-mu/du-ma. An analysis of other words of the same root is given and also is proposed the identificacion of *καλύθιον with ideogram *168. The likely translation of ka-ru-ti-je-ja-o could be «women makers or bearers of little baskets».

Constant exposure technique in industrial radiography

International Nuclear Information System (INIS)

Domanus, J.C.

1983-08-01

The principles and advantages of the constant exposure technique are explained. Choice of exposure factors is analyzed. Film, paper and intensifying screens used throughout the investigation and film and paper processing are described. Exposure technique and the use of image quality indicators are given. Methods of determining of radiographic image quality are presented. Conclusions about the use of constant exposure vs. constant kilovoltage technique are formulated. (author)

Cosmological constant--the weight of the vacuum

International Nuclear Information System (INIS)

Padmanabhan, T.

2003-01-01

Recent cosmological observations suggest the existence of a positive cosmological constant Λ with the magnitude Λ(Gℎ/c 3 )∼10 -123 . This review discusses several aspects of the cosmological constant both from the cosmological (Sections 1-6) and field theoretical (Sections 7-11) perspectives. After a brief introduction to the key issues related to cosmological constant and a historical overview, a summary of the kinematics and dynamics of the standard Friedmann model of the universe is provided. The observational evidence for cosmological constant, especially from the supernova results, and the constraints from the age of the universe, structure formation, Cosmic Microwave Background Radiation (CMBR) anisotropies and a few others are described in detail, followed by a discussion of the theoretical models (quintessence, tachyonic scalar field, ...) from different perspectives. The latter part of the review (Sections 7-11) concentrates on more conceptual and fundamental aspects of the cosmological constant like some alternative interpretations of the cosmological constant, relaxation mechanisms to reduce the cosmological constant to the currently observed value, the geometrical structure of the de Sitter spacetime, thermodynamics of the de Sitter universe and the role of string theory in the cosmological constant problem

Isolation and evaluation of Candida species and their association ...

African Journals Online (AJOL)

species and their association with CD4+ T cells counts in HIV patients with diarrhoea. Afri Health Sci. .... All reported p values were two-sided and a p-value ..... HIV epidemiology in Ni- geria. .... Yoganbi KA, Mbacham WF, Nubia KK, Singh RM.

"Kui Eesti ütleb gaasitorule ei, võib ka Rootsi öelda ei" / Carl B. Hamilton ; interv. Argo Ideon

Index Scriptorium Estoniae

Hamilton, Carl B.

2007-01-01

Nord Stream on avaldanud soovi gaasijuhtme teenindusplatvormi rajamiseks Gotlandi juurde. Parlamendiliikme hinnangul peaks Rootsi valitsus ütlema ei nii teenindusplatvormile kui ka gaasitorule. Gaasijuhe on tema sõnul Venemaa projekt

Radiographic constant exposure technique

DEFF Research Database (Denmark)

Domanus, Joseph Czeslaw

1985-01-01

The constant exposure technique has been applied to assess various industrial radiographic systems. Different X-ray films and radiographic papers of two producers were compared. Special attention was given to fast film and paper used with fluorometallic screens. Radiographic image quality...... was tested by the use of ISO wire IQI's and ASTM penetrameters used on Al and Fe test plates. Relative speed and reduction of kilovoltage obtained with the constant exposure technique were calculated. The advantages of fast radiographic systems are pointed out...

Constant-roll tachyon inflation and observational constraints

Science.gov (United States)

Gao, Qing; Gong, Yungui; Fei, Qin

2018-05-01

For the constant-roll tachyon inflation, we derive the analytical expressions for the scalar and tensor power spectra, the scalar and tensor spectral tilts and the tensor to scalar ratio to the first order of epsilon1 by using the method of Bessel function approximation. The derived ns-r results are compared with the observations, we find that only the constant-roll inflation with ηH being a constant is consistent with the observations and observations constrain the constant-roll inflation to be slow-roll inflation. The tachyon potential is also reconstructed for the constant-roll inflation which is consistent with the observations.

High Efficiency Traveling-Wave Tube Power Amplifier for Ka-Band Software Defined Radio on International Space Station-A Platform for Communications Technology Development

Science.gov (United States)

Simons, Rainee N.; Force, Dale A.; Kacpura, Thomas J.

2013-01-01

The design, fabrication and RF performance of the output traveling-wave tube amplifier (TWTA) for a space based Ka-band software defined radio (SDR) is presented. The TWTA, the SDR and the supporting avionics are integrated to forms a testbed, which is currently located on an exterior truss of the International Space Station (ISS). The SDR in the testbed communicates at Ka-band frequencies through a high-gain antenna directed to NASA s Tracking and Data Relay Satellite System (TDRSS), which communicates to the ground station located at White Sands Complex. The application of the testbed is for demonstrating new waveforms and software designed to enhance data delivery from scientific spacecraft and, the waveforms and software can be upgraded and reconfigured from the ground. The construction and the salient features of the Ka-band SDR are discussed. The testbed is currently undergoing on-orbit checkout and commissioning and is expected to operate for 3 to 5 years in space.

Graviton fluctuations erase the cosmological constant

Science.gov (United States)

Wetterich, C.

2017-10-01

Graviton fluctuations induce strong non-perturbative infrared renormalization effects for the cosmological constant. The functional renormalization flow drives a positive cosmological constant towards zero, solving the cosmological constant problem without the need to tune parameters. We propose a simple computation of the graviton contribution to the flow of the effective potential for scalar fields. Within variable gravity, with effective Planck mass proportional to the scalar field, we find that the potential increases asymptotically at most quadratically with the scalar field. The solutions of the derived cosmological equations lead to an asymptotically vanishing cosmological "constant" in the infinite future, providing for dynamical dark energy in the present cosmological epoch. Beyond a solution of the cosmological constant problem, our simplified computation also entails a sizeable positive graviton-induced anomalous dimension for the quartic Higgs coupling in the ultraviolet regime, substantiating the successful prediction of the Higgs boson mass within the asymptotic safety scenario for quantum gravity.

Living with constant suffering: a different life following the diagnosis of HIV.

Science.gov (United States)

Leyva-Moral, Juan M; de Dios Sánchez, Rosa; Lluva-Castaño, Alicia; Mestres-Camps, Lourdes

2015-01-01

We used grounded theory in semi-structured interviews with 32 persons living with HIV (PLWH) in Barcelona, Spain, and found that PLWH live with constant suffering, a core category combining four realities: I need help; My life is constantly controlled; I have a new imposed life; and I have an uncertain reality. Participants described being constantly controlled by health policies and medications. They thought their lives were in the hands of others and that a new life, characterized by the constant fear of stigma, had been imposed on them. They felt they were losing freedom and vitality, as many questions remained unanswered, causing uncertainty related to health and public life. Emotional help was obtained mainly from peers and social networks. Our emergent theory shows a disruptive experience, with serious consequences to individual and social development. Health care has to focus on the real needs of PLWH to reduce suffering and uncertainty. Copyright © 2015 Association of Nurses in AIDS Care. Published by Elsevier Inc. All rights reserved.